paragraph_index int64 | sec string | p_has_citation int64 | cites string | citeids list | pmid int64 | cited_id string | sentences string | all_sent_cites list | sent_len int64 | sentence_batch_index int64 | sent_has_citation float64 | qc_fail bool | cited_sentence string | cites_in_sentence list | cln_sentence string | is_cap bool | is_alpha bool | ends_wp bool | cit_qc bool | lgtm bool | __index_level_0__ int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | INTRODUCTION | 1 | 4 | [
"B4",
"B5",
"B6"
] | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | SLiMs of this type can be found by searching for motifs which are shared between proteins with a common attribute (such as biological function, subcellular location or a common interaction partner) and have no evidence of a shared ancestry. | [
"4",
"5",
"6"
] | 240 | 7,600 | 0 | false | SLiMs of this type can be found by searching for motifs which are shared between proteins with a common attribute (such as biological function, subcellular location or a common interaction partner) and have no evidence of a shared ancestry. | [] | SLiMs of this type can be found by searching for motifs which are shared between proteins with a common attribute (such as biological function, subcellular location or a common interaction partner) and have no evidence of a shared ancestry. | true | true | true | true | true | 1,232 |
1 | INTRODUCTION | 1 | 6 | [
"B4",
"B5",
"B6"
] | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | This approach has been implemented for motif discovery in the LMD/DILIMOT (4,5) and Short, Linear Motif Discovery (SLiMDisc) methods (6), which incorporate both masking and evolutionary filtering to return overrepresented motifs. | [
"4",
"5",
"6"
] | 229 | 7,601 | 1 | false | This approach has been implemented for motif discovery in the LMD/DILIMOT and Short, Linear Motif Discovery (SLiMDisc) methods, which incorporate both masking and evolutionary filtering to return overrepresented motifs. | [
"4,5",
"6"
] | This approach has been implemented for motif discovery in the LMD/DILIMOT and Short, Linear Motif Discovery (SLiMDisc) methods, which incorporate both masking and evolutionary filtering to return overrepresented motifs. | true | true | true | true | true | 1,232 |
1 | INTRODUCTION | 1 | 4 | [
"B4",
"B5",
"B6"
] | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | The principal underlying difference between the two methods is that DILIMOT masks all but one arbitrarily selected homologous protein prior to motif discovery, whereas SLiMDisc searches for motifs in all proteins and then weights results according to the evolutionarily relationships of the proteins containing the motif... | [
"4",
"5",
"6"
] | 321 | 7,602 | 0 | false | The principal underlying difference between the two methods is that DILIMOT masks all but one arbitrarily selected homologous protein prior to motif discovery, whereas SLiMDisc searches for motifs in all proteins and then weights results according to the evolutionarily relationships of the proteins containing the motif... | [] | The principal underlying difference between the two methods is that DILIMOT masks all but one arbitrarily selected homologous protein prior to motif discovery, whereas SLiMDisc searches for motifs in all proteins and then weights results according to the evolutionarily relationships of the proteins containing the motif... | true | true | true | true | true | 1,232 |
2 | INTRODUCTION | 1 | 6 | [
"B6"
] | 17,576,682 | pmid-16855291 | This article describes a web-based application of the SLiMDisc method, adding interactive masking of protein features, useful data visualizations and additional ranking and filtering options compared with the standalone program (6). | [
"6"
] | 232 | 7,603 | 1 | false | This article describes a web-based application of the SLiMDisc method, adding interactive masking of protein features, useful data visualizations and additional ranking and filtering options compared with the standalone program. | [
"6"
] | This article describes a web-based application of the SLiMDisc method, adding interactive masking of protein features, useful data visualizations and additional ranking and filtering options compared with the standalone program. | true | true | true | true | true | 1,233 |
2 | INTRODUCTION | 1 | 6 | [
"B6"
] | 17,576,682 | pmid-16855291 | While interpretation of motifs requires first a ranked scoring of the most significant motifs, the context of the motif is of great importance in evaluating how likely it is to be of interest to investigate further. | [
"6"
] | 215 | 7,604 | 0 | false | While interpretation of motifs requires first a ranked scoring of the most significant motifs, the context of the motif is of great importance in evaluating how likely it is to be of interest to investigate further. | [] | While interpretation of motifs requires first a ranked scoring of the most significant motifs, the context of the motif is of great importance in evaluating how likely it is to be of interest to investigate further. | true | true | true | true | true | 1,233 |
2 | INTRODUCTION | 1 | 6 | [
"B6"
] | 17,576,682 | pmid-16855291 | SLiMDisc permits rapid visualization of aspects of motif context, such as possible weak, uncorrected evolutionary relationships between proteins sharing the motif, the level of disorder of the protein region (often motifs are enriched in disordered regions) and the evolutionary divergence of the motif in homologues. | [
"6"
] | 317 | 7,605 | 0 | false | SLiMDisc permits rapid visualization of aspects of motif context, such as possible weak, uncorrected evolutionary relationships between proteins sharing the motif, the level of disorder of the protein region (often motifs are enriched in disordered regions) and the evolutionary divergence of the motif in homologues. | [] | SLiMDisc permits rapid visualization of aspects of motif context, such as possible weak, uncorrected evolutionary relationships between proteins sharing the motif, the level of disorder of the protein region (often motifs are enriched in disordered regions) and the evolutionary divergence of the motif in homologues. | true | true | true | true | true | 1,233 |
3 | INTRODUCTION | 1 | 6 | [
"B6"
] | 17,576,682 | pmid-16855291 | Examples of SLiMDisc applied to interaction data sets have been discussed previously when it was shown to successfully recover known shared linear motifs from the HPRD-curated protein interaction database (6). | [
"6"
] | 209 | 7,606 | 1 | false | Examples of SLiMDisc applied to interaction data sets have been discussed previously when it was shown to successfully recover known shared linear motifs from the HPRD-curated protein interaction database. | [
"6"
] | Examples of SLiMDisc applied to interaction data sets have been discussed previously when it was shown to successfully recover known shared linear motifs from the HPRD-curated protein interaction database. | true | true | true | true | true | 1,234 |
3 | INTRODUCTION | 1 | 6 | [
"B6"
] | 17,576,682 | pmid-16855291 | Here we describe the SLIMDisc web server, which implements this stand-alone program, and provides in addition important visualization tools to aid interpretation of the results. | [
"6"
] | 177 | 7,607 | 0 | false | Here we describe the SLIMDisc web server, which implements this stand-alone program, and provides in addition important visualization tools to aid interpretation of the results. | [] | Here we describe the SLIMDisc web server, which implements this stand-alone program, and provides in addition important visualization tools to aid interpretation of the results. | true | true | true | true | true | 1,234 |
3 | INTRODUCTION | 1 | 6 | [
"B6"
] | 17,576,682 | pmid-16855291 | This article illustrates the flexibility of the SLiMDisc server through an example application to a real biological data set. | [
"6"
] | 125 | 7,608 | 0 | false | This article illustrates the flexibility of the SLiMDisc server through an example application to a real biological data set. | [] | This article illustrates the flexibility of the SLiMDisc server through an example application to a real biological data set. | true | true | true | true | true | 1,234 |
0 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-15943979|pmid-12824381|pmid-16962311 | We have created a web server for the SLiMDisc method for the discovery of putatively interesting motifs in protein data sets which haves some common attributes which may be explained by a shared motif. | null | 201 | 7,609 | 0 | false | null | null | We have created a web server for the SLiMDisc method for the discovery of putatively interesting motifs in protein data sets which haves some common attributes which may be explained by a shared motif. | true | true | true | true | true | 1,235 |
0 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-15943979|pmid-12824381|pmid-16962311 | We introduced interactive masking (inclusive and exclusive) of annotated protein features on a protein by protein basis to decrease the search space and increase the likelihood of returning motifs of interest. | null | 209 | 7,610 | 0 | false | null | null | We introduced interactive masking (inclusive and exclusive) of annotated protein features on a protein by protein basis to decrease the search space and increase the likelihood of returning motifs of interest. | true | true | true | true | true | 1,235 |
0 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-15943979|pmid-12824381|pmid-16962311 | We have also demonstrated how the use of visualization can be used to help distinguish biologically meaningful SLiMs from the noise of stochastically occurring background motifs. | null | 178 | 7,611 | 0 | false | null | null | We have also demonstrated how the use of visualization can be used to help distinguish biologically meaningful SLiMs from the noise of stochastically occurring background motifs. | true | true | true | true | true | 1,235 |
1 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | SLiM discovery is a difficult task that has often been compared with finding a needle in a haystack. | null | 100 | 7,612 | 0 | false | null | null | SLiM discovery is a difficult task that has often been compared with finding a needle in a haystack. | true | true | true | true | true | 1,236 |
1 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | Their short length, high ambiguity and low-binding affinities makes them unfavourable for experimental or in silico discovery, and the lack of adequate training data sets makes it hard to develop robust discovery algorithms that are fully automated. | null | 249 | 7,613 | 0 | false | null | null | Their short length, high ambiguity and low-binding affinities makes them unfavourable for experimental or in silico discovery, and the lack of adequate training data sets makes it hard to develop robust discovery algorithms that are fully automated. | true | true | true | true | true | 1,236 |
1 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | Current methods are only likely to discover the most easily revealed motifs. | null | 76 | 7,614 | 0 | false | null | null | Current methods are only likely to discover the most easily revealed motifs. | true | true | true | true | true | 1,236 |
1 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | At this time, SLiM discovery difficulties are best overcome by a combination of automated discovery followed by visual inspection of putatively functional motifs, and the supervised incorporation of as much expert knowledge as possible through data set masking and results filtering. | null | 283 | 7,615 | 0 | false | null | null | At this time, SLiM discovery difficulties are best overcome by a combination of automated discovery followed by visual inspection of putatively functional motifs, and the supervised incorporation of as much expert knowledge as possible through data set masking and results filtering. | true | true | true | true | true | 1,236 |
1 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | Motif attributes, such as motif conservation in close orthologues or common motif position relative to other protein features, can all point to true functionality that is most easily described by visualization. | null | 210 | 7,616 | 0 | false | null | null | Motif attributes, such as motif conservation in close orthologues or common motif position relative to other protein features, can all point to true functionality that is most easily described by visualization. | true | true | true | true | true | 1,236 |
1 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | The overall context of a motif allows the user to gain confidence in motifs and helps the user to separate true motifs from the background of randomly occurring motifs with high support. | null | 186 | 7,617 | 0 | false | null | null | The overall context of a motif allows the user to gain confidence in motifs and helps the user to separate true motifs from the background of randomly occurring motifs with high support. | true | true | true | true | true | 1,236 |
1 | DISCUSSION | 0 | null | null | 17,576,682 | pmid-16845024|pmid-16279839|pmid-16855291 | As more SLiMs are discovered and confirmed experimentally, it is hoped that our overall knowledge of the area will increase and allow more sophisticated—and more accurate—algorithms to be developed. | null | 198 | 7,618 | 0 | false | null | null | As more SLiMs are discovered and confirmed experimentally, it is hoped that our overall knowledge of the area will increase and allow more sophisticated—and more accurate—algorithms to be developed. | true | true | true | true | true | 1,236 |
0 | INTRODUCTION | 1 | 1 | [
"B1",
"B2",
"B3",
"B4",
"B5",
"B6",
"B7",
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | The nucleosome is the most highly conserved fundamental repeating unit of eukaryotic chromatin. | [
"1",
"2",
"3",
"4",
"5",
"6",
"7",
"6",
"7"
] | 95 | 7,619 | 0 | false | The nucleosome is the most highly conserved fundamental repeating unit of eukaryotic chromatin. | [] | The nucleosome is the most highly conserved fundamental repeating unit of eukaryotic chromatin. | true | true | true | true | true | 1,237 |
0 | INTRODUCTION | 1 | 1 | [
"B1",
"B2",
"B3",
"B4",
"B5",
"B6",
"B7",
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | The nucleosome core is formed by an octamer comprised of two copies of each histone protein, H2A, H2B, H3 and H4, around which 145–147 bp of DNA is wrapped twice. | [
"1",
"2",
"3",
"4",
"5",
"6",
"7",
"6",
"7"
] | 162 | 7,620 | 0 | false | The nucleosome core is formed by an octamer comprised of two copies of each histone protein, H2A, H2B, H3 and H4, around which 145–147 bp of DNA is wrapped twice. | [] | The nucleosome core is formed by an octamer comprised of two copies of each histone protein, H2A, H2B, H3 and H4, around which 145–147 bp of DNA is wrapped twice. | true | true | true | true | true | 1,237 |
0 | INTRODUCTION | 1 | 1 | [
"B1",
"B2",
"B3",
"B4",
"B5",
"B6",
"B7",
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | Appropriate levels of histone expression are critical for transcription, chromosome segregation, repair, and other chromatin-mediated processes (1). | [
"1",
"2",
"3",
"4",
"5",
"6",
"7",
"6",
"7"
] | 148 | 7,621 | 1 | false | Appropriate levels of histone expression are critical for transcription, chromosome segregation, repair, and other chromatin-mediated processes. | [
"1"
] | Appropriate levels of histone expression are critical for transcription, chromosome segregation, repair, and other chromatin-mediated processes. | true | true | true | true | true | 1,237 |
0 | INTRODUCTION | 1 | 2 | [
"B1",
"B2",
"B3",
"B4",
"B5",
"B6",
"B7",
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | Histone genes are highly reiterated and are often organized into clusters (2). | [
"1",
"2",
"3",
"4",
"5",
"6",
"7",
"6",
"7"
] | 78 | 7,622 | 1 | false | Histone genes are highly reiterated and are often organized into clusters. | [
"2"
] | Histone genes are highly reiterated and are often organized into clusters. | true | true | true | true | true | 1,237 |
0 | INTRODUCTION | 1 | 3 | [
"B1",
"B2",
"B3",
"B4",
"B5",
"B6",
"B7",
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | For example, the majority of human histone genes are located in major and minor clusters on chromosomes 6p21 and 1q21, respectively (3), while the budding yeast, Saccharomyces cerevisiae, contains two copies of each pair of H2A-H2B and H3-H4 histone genes (4,5). | [
"1",
"2",
"3",
"4",
"5",
"6",
"7",
"6",
"7"
] | 262 | 7,623 | 1 | false | For example, the majority of human histone genes are located in major and minor clusters on chromosomes 6p21 and 1q21, respectively, while the budding yeast, Saccharomyces cerevisiae, contains two copies of each pair of H2A-H2B and H3-H4 histone genes. | [
"3",
"4,5"
] | For example, the majority of human histone genes are located in major and minor clusters on chromosomes 6p21 and 1q21, respectively, while the budding yeast, Saccharomyces cerevisiae, contains two copies of each pair of H2A-H2B and H3-H4 histone genes. | true | true | true | true | true | 1,237 |
0 | INTRODUCTION | 1 | 1 | [
"B1",
"B2",
"B3",
"B4",
"B5",
"B6",
"B7",
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | The fission yeast, Schizosaccharomyces pombe, investigated in the present study also has reiterated histone genes, the genomic organization of which consists of a single H2Aβ (hta2+), a pair of H2Aα-H2B (hta1+-htb1+), and three pairs of H3-H4 (hht1+-hhf1+, hht2+-hhf2+ and hht3+-hhf3+) (6,7). | [
"1",
"2",
"3",
"4",
"5",
"6",
"7",
"6",
"7"
] | 292 | 7,624 | 0 | false | The fission yeast, Schizosaccharomyces pombe, investigated in the present study also has reiterated histone genes, the genomic organization of which consists of a single H2Aβ, a pair of H2Aα-H2B, and three pairs of H3-H4. | [
"hta2+",
"hta1+-htb1+",
"hht1+-hhf1+, hht2+-hhf2+ and hht3+-hhf3+",
"6,7"
] | The fission yeast, Schizosaccharomyces pombe, investigated in the present study also has reiterated histone genes, the genomic organization of which consists of a single H2Aβ, a pair of H2Aα-H2B, and three pairs of H3-H4. | true | true | true | true | true | 1,237 |
0 | INTRODUCTION | 1 | 1 | [
"B1",
"B2",
"B3",
"B4",
"B5",
"B6",
"B7",
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | The amino acid sequences deduced from three copies of histone H3 genes or those of histone H4 genes are identical, while the two predicted H2A proteins differ by three amino acids (6,7). | [
"1",
"2",
"3",
"4",
"5",
"6",
"7",
"6",
"7"
] | 186 | 7,625 | 0 | false | The amino acid sequences deduced from three copies of histone H3 genes or those of histone H4 genes are identical, while the two predicted H2A proteins differ by three amino acids. | [
"6,7"
] | The amino acid sequences deduced from three copies of histone H3 genes or those of histone H4 genes are identical, while the two predicted H2A proteins differ by three amino acids. | true | true | true | true | true | 1,237 |
0 | INTRODUCTION | 1 | 1 | [
"B1",
"B2",
"B3",
"B4",
"B5",
"B6",
"B7",
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | Although the repetitive nature of the histone genes in the genome appears to be evolutionarily well conserved, its physiological significance remains obscure. | [
"1",
"2",
"3",
"4",
"5",
"6",
"7",
"6",
"7"
] | 158 | 7,626 | 0 | false | Although the repetitive nature of the histone genes in the genome appears to be evolutionarily well conserved, its physiological significance remains obscure. | [] | Although the repetitive nature of the histone genes in the genome appears to be evolutionarily well conserved, its physiological significance remains obscure. | true | true | true | true | true | 1,237 |
1 | INTRODUCTION | 1 | 8 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | Histone production is up-regulated at S-phase coinciding with nucleosome assembly during DNA replication (8). | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 109 | 7,627 | 1 | false | Histone production is up-regulated at S-phase coinciding with nucleosome assembly during DNA replication. | [
"8"
] | Histone production is up-regulated at S-phase coinciding with nucleosome assembly during DNA replication. | true | true | true | true | true | 1,238 |
1 | INTRODUCTION | 1 | 8 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | In S-phase, DNA synthesis and histone synthesis are highly regulated in a coordinated and concerted manner. | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 107 | 7,628 | 0 | false | In S-phase, DNA synthesis and histone synthesis are highly regulated in a coordinated and concerted manner. | [] | In S-phase, DNA synthesis and histone synthesis are highly regulated in a coordinated and concerted manner. | true | true | true | true | true | 1,238 |
1 | INTRODUCTION | 1 | 1 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | For example, in both yeast and higher eukaryotes, interference with DNA replication by genotoxic agents triggers repression of histone gene expression (1). | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 155 | 7,629 | 1 | false | For example, in both yeast and higher eukaryotes, interference with DNA replication by genotoxic agents triggers repression of histone gene expression. | [
"1"
] | For example, in both yeast and higher eukaryotes, interference with DNA replication by genotoxic agents triggers repression of histone gene expression. | true | true | true | true | true | 1,238 |
1 | INTRODUCTION | 1 | 9 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | Conversely, in human cells, the reduction of histone transcription by ectopic overproduction of a histone repressor leads to concerted blockage of DNA synthesis (9). | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 165 | 7,630 | 1 | false | Conversely, in human cells, the reduction of histone transcription by ectopic overproduction of a histone repressor leads to concerted blockage of DNA synthesis. | [
"9"
] | Conversely, in human cells, the reduction of histone transcription by ectopic overproduction of a histone repressor leads to concerted blockage of DNA synthesis. | true | true | true | true | true | 1,238 |
1 | INTRODUCTION | 1 | 8 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | In budding yeast, although DNA replication occurs in the absence of histone synthesis, passage through S-phase results in severe loss of cell viability (10,11). | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 160 | 7,631 | 0 | false | In budding yeast, although DNA replication occurs in the absence of histone synthesis, passage through S-phase results in severe loss of cell viability. | [
"10,11"
] | In budding yeast, although DNA replication occurs in the absence of histone synthesis, passage through S-phase results in severe loss of cell viability. | true | true | true | true | true | 1,238 |
1 | INTRODUCTION | 1 | 8 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | The increased histone synthesis during S-phase is due to regulation at both transcriptional and post-transcriptional levels. | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 124 | 7,632 | 0 | false | The increased histone synthesis during S-phase is due to regulation at both transcriptional and post-transcriptional levels. | [] | The increased histone synthesis during S-phase is due to regulation at both transcriptional and post-transcriptional levels. | true | true | true | true | true | 1,238 |
1 | INTRODUCTION | 1 | 1 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | In higher eukaryotes, although such transcriptional regulation contributes to several-fold increases in histone synthesis during S-phase, the majority is likely due to post-transcriptional regulation of histone mRNA processing and stability (1). | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 245 | 7,633 | 1 | false | In higher eukaryotes, although such transcriptional regulation contributes to several-fold increases in histone synthesis during S-phase, the majority is likely due to post-transcriptional regulation of histone mRNA processing and stability. | [
"1"
] | In higher eukaryotes, although such transcriptional regulation contributes to several-fold increases in histone synthesis during S-phase, the majority is likely due to post-transcriptional regulation of histone mRNA processing and stability. | true | true | true | true | true | 1,238 |
1 | INTRODUCTION | 1 | 8 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | The up-regulation of histone synthesis in budding yeast is thought to be achieved through both repression in G1- and G2-phases and transcriptional activation just before entry into S-phase. | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 189 | 7,634 | 0 | false | The up-regulation of histone synthesis in budding yeast is thought to be achieved through both repression in G1- and G2-phases and transcriptional activation just before entry into S-phase. | [] | The up-regulation of histone synthesis in budding yeast is thought to be achieved through both repression in G1- and G2-phases and transcriptional activation just before entry into S-phase. | true | true | true | true | true | 1,238 |
1 | INTRODUCTION | 1 | 14 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | Each of the budding yeast histone gene pairs is transcribed in divergent orientation from common regulatory elements (12,13), including upstream activator sequence repeats and a negative repressor element (14). | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 210 | 7,635 | 1 | false | Each of the budding yeast histone gene pairs is transcribed in divergent orientation from common regulatory elements, including upstream activator sequence repeats and a negative repressor element. | [
"12,13",
"14"
] | Each of the budding yeast histone gene pairs is transcribed in divergent orientation from common regulatory elements, including upstream activator sequence repeats and a negative repressor element. | true | true | true | true | true | 1,238 |
1 | INTRODUCTION | 1 | 8 | [
"B8",
"B1",
"B9",
"B10",
"B11",
"B1",
"B12",
"B13",
"B14"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | Although transcriptional activation at S-phase is a common feature of the histone genes conserved among species, it remains unclear whether conserved molecules are involved in the activation. | [
"8",
"1",
"9",
"10",
"11",
"1",
"12",
"13",
"14"
] | 191 | 7,636 | 0 | false | Although transcriptional activation at S-phase is a common feature of the histone genes conserved among species, it remains unclear whether conserved molecules are involved in the activation. | [] | Although transcriptional activation at S-phase is a common feature of the histone genes conserved among species, it remains unclear whether conserved molecules are involved in the activation. | true | true | true | true | true | 1,238 |
2 | INTRODUCTION | 1 | 1 | [
"B1",
"B15",
"B16",
"B15",
"B17",
"B18",
"B19",
"B20",
"B9"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | HIRA proteins are members of an evolutionarily highly conserved family of histone chaperones that have been implicated in nucleosome assembly (1). | [
"1",
"15",
"16",
"15",
"17",
"18",
"19",
"20",
"9"
] | 146 | 7,637 | 1 | false | HIRA proteins are members of an evolutionarily highly conserved family of histone chaperones that have been implicated in nucleosome assembly. | [
"1"
] | HIRA proteins are members of an evolutionarily highly conserved family of histone chaperones that have been implicated in nucleosome assembly. | true | true | true | true | true | 1,239 |
2 | INTRODUCTION | 1 | 1 | [
"B1",
"B15",
"B16",
"B15",
"B17",
"B18",
"B19",
"B20",
"B9"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | HIRA proteins were originally discovered as repressors of histone gene expression outside S-phase or in response to HU, an inhibitor of DNA replication in budding yeast (15,16). | [
"1",
"15",
"16",
"15",
"17",
"18",
"19",
"20",
"9"
] | 177 | 7,638 | 0 | false | HIRA proteins were originally discovered as repressors of histone gene expression outside S-phase or in response to HU, an inhibitor of DNA replication in budding yeast. | [
"15,16"
] | HIRA proteins were originally discovered as repressors of histone gene expression outside S-phase or in response to HU, an inhibitor of DNA replication in budding yeast. | true | true | true | true | true | 1,239 |
2 | INTRODUCTION | 1 | 1 | [
"B1",
"B15",
"B16",
"B15",
"B17",
"B18",
"B19",
"B20",
"B9"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | Two HIRA proteins, Hir1 and Hir2, restrict the expression of six of the eight core histone genes at S-phase in budding yeast (15,17). | [
"1",
"15",
"16",
"15",
"17",
"18",
"19",
"20",
"9"
] | 133 | 7,639 | 0 | false | Two HIRA proteins, Hir1 and Hir2, restrict the expression of six of the eight core histone genes at S-phase in budding yeast. | [
"15,17"
] | Two HIRA proteins, Hir1 and Hir2, restrict the expression of six of the eight core histone genes at S-phase in budding yeast. | true | true | true | true | true | 1,239 |
2 | INTRODUCTION | 1 | 18 | [
"B1",
"B15",
"B16",
"B15",
"B17",
"B18",
"B19",
"B20",
"B9"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | The fission yeast also has two related HIRA proteins, Slm9 (18) and Hip1 (19), whereas higher eukaryotes have only a single protein. | [
"1",
"15",
"16",
"15",
"17",
"18",
"19",
"20",
"9"
] | 132 | 7,640 | 1 | false | The fission yeast also has two related HIRA proteins, Slm9 and Hip1, whereas higher eukaryotes have only a single protein. | [
"18",
"19"
] | The fission yeast also has two related HIRA proteins, Slm9 and Hip1, whereas higher eukaryotes have only a single protein. | true | true | true | true | true | 1,239 |
2 | INTRODUCTION | 1 | 20 | [
"B1",
"B15",
"B16",
"B15",
"B17",
"B18",
"B19",
"B20",
"B9"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | In higher eukaryotes, HIRA has been identified as a critical component of a replication-independent nucleosome deposition pathway as a chaperone for histone octamers containing the H3.3 variant (20). | [
"1",
"15",
"16",
"15",
"17",
"18",
"19",
"20",
"9"
] | 199 | 7,641 | 1 | false | In higher eukaryotes, HIRA has been identified as a critical component of a replication-independent nucleosome deposition pathway as a chaperone for histone octamers containing the H3.3 variant. | [
"20"
] | In higher eukaryotes, HIRA has been identified as a critical component of a replication-independent nucleosome deposition pathway as a chaperone for histone octamers containing the H3.3 variant. | true | true | true | true | true | 1,239 |
2 | INTRODUCTION | 1 | 9 | [
"B1",
"B15",
"B16",
"B15",
"B17",
"B18",
"B19",
"B20",
"B9"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | HIRA is also involved in transcriptional regulation, as over-expression of HIRA in human cells in tissue culture results in histone gene repression (9). | [
"1",
"15",
"16",
"15",
"17",
"18",
"19",
"20",
"9"
] | 152 | 7,642 | 1 | false | HIRA is also involved in transcriptional regulation, as over-expression of HIRA in human cells in tissue culture results in histone gene repression. | [
"9"
] | HIRA is also involved in transcriptional regulation, as over-expression of HIRA in human cells in tissue culture results in histone gene repression. | true | true | true | true | true | 1,239 |
2 | INTRODUCTION | 1 | 1 | [
"B1",
"B15",
"B16",
"B15",
"B17",
"B18",
"B19",
"B20",
"B9"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | It remains to be determined whether and how these two activities are functionally related. | [
"1",
"15",
"16",
"15",
"17",
"18",
"19",
"20",
"9"
] | 90 | 7,643 | 0 | false | It remains to be determined whether and how these two activities are functionally related. | [] | It remains to be determined whether and how these two activities are functionally related. | true | true | true | true | true | 1,239 |
3 | INTRODUCTION | 1 | 21 | [
"B21",
"B21",
"B22",
"B21",
"B22",
"B21",
"B23",
"B22",
"B24",
"B21"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | Histone genes can be classified into three main subtypes based on their expression pattern and genomic organization: replication-dependent, replication- and cell cycle phase-independent, and tissue-specific histones (21). | [
"21",
"21",
"22",
"21",
"22",
"21",
"23",
"22",
"24",
"21"
] | 221 | 7,644 | 1 | false | Histone genes can be classified into three main subtypes based on their expression pattern and genomic organization: replication-dependent, replication- and cell cycle phase-independent, and tissue-specific histones. | [
"21"
] | Histone genes can be classified into three main subtypes based on their expression pattern and genomic organization: replication-dependent, replication- and cell cycle phase-independent, and tissue-specific histones. | true | true | true | true | true | 1,240 |
3 | INTRODUCTION | 1 | 21 | [
"B21",
"B21",
"B22",
"B21",
"B22",
"B21",
"B23",
"B22",
"B24",
"B21"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | Higher eukaryotes, including humans, have three H3 histone variants, H3.1, H3.2 and H3.3. | [
"21",
"21",
"22",
"21",
"22",
"21",
"23",
"22",
"24",
"21"
] | 89 | 7,645 | 0 | false | Higher eukaryotes, including humans, have three H3 histone variants, H3.1, H3.2 and H3.3. | [] | Higher eukaryotes, including humans, have three H3 histone variants, H3.1, H3.2 and H3.3. | true | true | true | true | true | 1,240 |
3 | INTRODUCTION | 1 | 21 | [
"B21",
"B21",
"B22",
"B21",
"B22",
"B21",
"B23",
"B22",
"B24",
"B21"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | The major H3 histones, H3.1 and H3.2, have only a single amino acid difference, and are synthesized and deposited on DNA strictly during DNA replication (21,22). | [
"21",
"21",
"22",
"21",
"22",
"21",
"23",
"22",
"24",
"21"
] | 161 | 7,646 | 0 | false | The major H3 histones, H3.1 and H3.2, have only a single amino acid difference, and are synthesized and deposited on DNA strictly during DNA replication. | [
"21,22"
] | The major H3 histones, H3.1 and H3.2, have only a single amino acid difference, and are synthesized and deposited on DNA strictly during DNA replication. | true | true | true | true | true | 1,240 |
3 | INTRODUCTION | 1 | 21 | [
"B21",
"B21",
"B22",
"B21",
"B22",
"B21",
"B23",
"B22",
"B24",
"B21"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | H3.3 differs from H3.2 in five amino acids in humans and is synthesized and deposited on DNA throughout the cell cycle (21,22). | [
"21",
"21",
"22",
"21",
"22",
"21",
"23",
"22",
"24",
"21"
] | 127 | 7,647 | 0 | false | H3.3 differs from H3.2 in five amino acids in humans and is synthesized and deposited on DNA throughout the cell cycle. | [
"21,22"
] | H3.3 differs from H3.2 in five amino acids in humans and is synthesized and deposited on DNA throughout the cell cycle. | true | true | true | true | true | 1,240 |
3 | INTRODUCTION | 1 | 21 | [
"B21",
"B21",
"B22",
"B21",
"B22",
"B21",
"B23",
"B22",
"B24",
"B21"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | Interestingly, observations in flies and humans indicate that H3.3 is associated with transcriptionally active gene loci and is enriched in covalent modifications associated with gene activation (21,23). | [
"21",
"21",
"22",
"21",
"22",
"21",
"23",
"22",
"24",
"21"
] | 203 | 7,648 | 0 | false | Interestingly, observations in flies and humans indicate that H3.3 is associated with transcriptionally active gene loci and is enriched in covalent modifications associated with gene activation. | [
"21,23"
] | Interestingly, observations in flies and humans indicate that H3.3 is associated with transcriptionally active gene loci and is enriched in covalent modifications associated with gene activation. | true | true | true | true | true | 1,240 |
3 | INTRODUCTION | 1 | 22 | [
"B21",
"B21",
"B22",
"B21",
"B22",
"B21",
"B23",
"B22",
"B24",
"B21"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | In contrast, H3.2 has been shown to be enriched in markers associated with gene silencing (22). | [
"21",
"21",
"22",
"21",
"22",
"21",
"23",
"22",
"24",
"21"
] | 95 | 7,649 | 1 | false | In contrast, H3.2 has been shown to be enriched in markers associated with gene silencing. | [
"22"
] | In contrast, H3.2 has been shown to be enriched in markers associated with gene silencing. | true | true | true | true | true | 1,240 |
3 | INTRODUCTION | 1 | 24 | [
"B21",
"B21",
"B22",
"B21",
"B22",
"B21",
"B23",
"B22",
"B24",
"B21"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | The transcriptional state at the loci may be a critical determinant for H3.3 deposition (24). | [
"21",
"21",
"22",
"21",
"22",
"21",
"23",
"22",
"24",
"21"
] | 93 | 7,650 | 1 | false | The transcriptional state at the loci may be a critical determinant for H3.3 deposition. | [
"24"
] | The transcriptional state at the loci may be a critical determinant for H3.3 deposition. | true | true | true | true | true | 1,240 |
3 | INTRODUCTION | 1 | 21 | [
"B21",
"B21",
"B22",
"B21",
"B22",
"B21",
"B23",
"B22",
"B24",
"B21"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | In contrast, yeasts have only a single H3 protein; the budding yeast genome possesses only H3.3-type histone genes, while the fission yeast H3 genes encode an identical hybrid protein exhibiting characteristics of both H3.3 and H3.2 (21). | [
"21",
"21",
"22",
"21",
"22",
"21",
"23",
"22",
"24",
"21"
] | 238 | 7,651 | 1 | false | In contrast, yeasts have only a single H3 protein; the budding yeast genome possesses only H3.3-type histone genes, while the fission yeast H3 genes encode an identical hybrid protein exhibiting characteristics of both H3.3 and H3.2. | [
"21"
] | In contrast, yeasts have only a single H3 protein; the budding yeast genome possesses only H3.3-type histone genes, while the fission yeast H3 genes encode an identical hybrid protein exhibiting characteristics of both H3.3 and H3.2. | true | true | true | true | true | 1,240 |
4 | INTRODUCTION | 1 | 25 | [
"B25",
"B26",
"B26",
"B25",
"B25"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | In this study, we characterized the transcriptional properties of individual histone H3 and H4 genes throughout the cell cycle using the genetically tractable model organism, S. pombe. | [
"25",
"26",
"26",
"25",
"25"
] | 184 | 7,652 | 0 | false | In this study, we characterized the transcriptional properties of individual histone H3 and H4 genes throughout the cell cycle using the genetically tractable model organism, S. pombe. | [] | In this study, we characterized the transcriptional properties of individual histone H3 and H4 genes throughout the cell cycle using the genetically tractable model organism, S. pombe. | true | true | true | true | true | 1,241 |
4 | INTRODUCTION | 1 | 25 | [
"B25",
"B26",
"B26",
"B25",
"B25"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | The DNA sequences of reiterated histone genes within the coding region in S. pombe show significant identity among the copies, while the 5′- and 3′-untranslated regions (UTRs) show divergence. | [
"25",
"26",
"26",
"25",
"25"
] | 192 | 7,653 | 0 | false | The DNA sequences of reiterated histone genes within the coding region in S. pombe show significant identity among the copies, while the 5′- and 3′-untranslated regions (UTRs) show divergence. | [] | The DNA sequences of reiterated histone genes within the coding region in S. pombe show significant identity among the copies, while the 5′- and 3′-untranslated regions (UTRs) show divergence. | true | true | true | true | true | 1,241 |
4 | INTRODUCTION | 1 | 25 | [
"B25",
"B26",
"B26",
"B25",
"B25"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | Hereafter, we refer to the three pairs of H3-H4 genes (hht1+-hhf1+, hht2+-hhf2+ and hht3+-hhf3+) as copy-1, -2 and -3, respectively (Figures 2A and 3). | [
"25",
"26",
"26",
"25",
"25"
] | 151 | 7,654 | 0 | false | Hereafter, we refer to the three pairs of H3-H4 genes (hht1+-hhf1+, hht2+-hhf2+ and hht3+-hhf3+) as copy-1, -2 and -3, respectively (Figures 2A and 3). | [] | Hereafter, we refer to the three pairs of H3-H4 genes as copy-1, -2 and -3, respectively. | true | true | true | true | true | 1,241 |
4 | INTRODUCTION | 1 | 25 | [
"B25",
"B26",
"B26",
"B25",
"B25"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | A quantitative reverse transcription polymerase chain reaction (RT-PCR) method with allele-specific probes was used for precise comparison of the relative levels of transcripts derived from reiterated histone genes among wild-type, histone gene deletion mutants, and mutants in which histone transcription is compromised... | [
"25",
"26",
"26",
"25",
"25"
] | 321 | 7,655 | 0 | false | A quantitative reverse transcription polymerase chain reaction (RT-PCR) method with allele-specific probes was used for precise comparison of the relative levels of transcripts derived from reiterated histone genes among wild-type, histone gene deletion mutants, and mutants in which histone transcription is compromised... | [] | A quantitative reverse transcription polymerase chain reaction (RT-PCR) method with allele-specific probes was used for precise comparison of the relative levels of transcripts derived from reiterated histone genes among wild-type, histone gene deletion mutants, and mutants in which histone transcription is compromised... | true | true | true | true | true | 1,241 |
4 | INTRODUCTION | 1 | 25 | [
"B25",
"B26",
"B26",
"B25",
"B25"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | We identified Ams2, a cell cycle-regulated GATA-type transcription factor (25,26), as an activator of core histone genes at S-phase. | [
"25",
"26",
"26",
"25",
"25"
] | 132 | 7,656 | 0 | false | We identified Ams2, a cell cycle-regulated GATA-type transcription factor, as an activator of core histone genes at S-phase. | [
"25,26"
] | We identified Ams2, a cell cycle-regulated GATA-type transcription factor, as an activator of core histone genes at S-phase. | true | true | true | true | true | 1,241 |
4 | INTRODUCTION | 1 | 26 | [
"B25",
"B26",
"B26",
"B25",
"B25"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | protein has a zinc finger motif that is characteristic of the family of GATA-type transcription factors, some of which have been reported to bind to GATA-containing DNA consensus sequences (26). | [
"25",
"26",
"26",
"25",
"25"
] | 194 | 7,657 | 1 | false | protein has a zinc finger motif that is characteristic of the family of GATA-type transcription factors, some of which have been reported to bind to GATA-containing DNA consensus sequences. | [
"26"
] | protein has a zinc finger motif that is characteristic of the family of GATA-type transcription factors, some of which have been reported to bind to GATA-containing DNA consensus sequences. | false | true | true | true | false | 1,241 |
4 | INTRODUCTION | 1 | 25 | [
"B25",
"B26",
"B26",
"B25",
"B25"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | Indeed, Ams2 has been shown to exhibit DNA-binding activity to a GATA sequence in vitro (25). | [
"25",
"26",
"26",
"25",
"25"
] | 93 | 7,658 | 1 | false | Indeed, Ams2 has been shown to exhibit DNA-binding activity to a GATA sequence in vitro. | [
"25"
] | Indeed, Ams2 has been shown to exhibit DNA-binding activity to a GATA sequence in vitro. | true | true | true | true | true | 1,241 |
4 | INTRODUCTION | 1 | 25 | [
"B25",
"B26",
"B26",
"B25",
"B25"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | Ams2 accumulates on the nuclear chromatin when chromosomes are duplicated during S-phase, whereas little accumulation of this protein was detected in mid-to-late G2 or early M-phase (25). | [
"25",
"26",
"26",
"25",
"25"
] | 187 | 7,659 | 1 | false | Ams2 accumulates on the nuclear chromatin when chromosomes are duplicated during S-phase, whereas little accumulation of this protein was detected in mid-to-late G2 or early M-phase. | [
"25"
] | Ams2 accumulates on the nuclear chromatin when chromosomes are duplicated during S-phase, whereas little accumulation of this protein was detected in mid-to-late G2 or early M-phase. | true | true | true | true | true | 1,241 |
4 | INTRODUCTION | 1 | 25 | [
"B25",
"B26",
"B26",
"B25",
"B25"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | The results of the present study indicated the differential transcriptional regulation of three histone gene pairs, which is probably controlled by a combination of Ams2-dependent transcriptional activation at S-phase and Ams2-independent constitutive transcription throughout the cell cycle. | [
"25",
"26",
"26",
"25",
"25"
] | 292 | 7,660 | 0 | false | The results of the present study indicated the differential transcriptional regulation of three histone gene pairs, which is probably controlled by a combination of Ams2-dependent transcriptional activation at S-phase and Ams2-independent constitutive transcription throughout the cell cycle. | [] | The results of the present study indicated the differential transcriptional regulation of three histone gene pairs, which is probably controlled by a combination of Ams2-dependent transcriptional activation at S-phase and Ams2-independent constitutive transcription throughout the cell cycle. | true | true | true | true | true | 1,241 |
0 | DISCUSSION | 1 | 6 | [
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | The results of the present study demonstrated that Ams2 GATA factor is an essential component of a transcriptional activator for all core histone genes during S-phase. | [
"6",
"7"
] | 167 | 7,661 | 0 | false | The results of the present study demonstrated that Ams2 GATA factor is an essential component of a transcriptional activator for all core histone genes during S-phase. | [] | The results of the present study demonstrated that Ams2 GATA factor is an essential component of a transcriptional activator for all core histone genes during S-phase. | true | true | true | true | true | 1,242 |
0 | DISCUSSION | 1 | 6 | [
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | We found that Ams2 binds directly to the promoter regions of all the core histone genes in vivo in an AACCCT-box-dependent manner (Figure 2C). | [
"6",
"7"
] | 142 | 7,662 | 0 | false | We found that Ams2 binds directly to the promoter regions of all the core histone genes in vivo in an AACCCT-box-dependent manner (Figure 2C). | [] | We found that Ams2 binds directly to the promoter regions of all the core histone genes in vivo in an AACCCT-box-dependent manner (Figure 2C). | true | true | true | true | true | 1,242 |
0 | DISCUSSION | 1 | 6 | [
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | The 17-bp AACCCT-box [5′-ATCA(C/A)AACCCTAACCCT-3′] was identified previously as a common DNA sequence located upstream of core histone genes (6,7). | [
"6",
"7"
] | 147 | 7,663 | 0 | false | The 17-bp AACCCT-box [5′-ATCA(C/A)AACCCTAACCCT-3′] was identified previously as a common DNA sequence located upstream of core histone genes. | [
"6,7"
] | The 17-bp AACCCT-box [5′-ATCA(C/A)AACCCTAACCCT-3′] was identified previously as a common DNA sequence located upstream of core histone genes. | true | true | true | true | true | 1,242 |
0 | DISCUSSION | 1 | 6 | [
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | Although the AACCCT-box does not show a perfect match to the GATA consensus sequence, similar sequences (5′-GATn-3′ and 5′-GtTA-3′) were found within the box in the reverse strand and are potential candidates for Ams2-binding sites. | [
"6",
"7"
] | 232 | 7,664 | 0 | false | Although the AACCCT-box does not show a perfect match to the GATA consensus sequence, similar sequences (5′-GATn-3′ and 5′-GtTA-3′) were found within the box in the reverse strand and are potential candidates for Ams2-binding sites. | [] | Although the AACCCT-box does not show a perfect match to the GATA consensus sequence, similar sequences (5′-GATn-3′ and 5′-GtTA-3′) were found within the box in the reverse strand and are potential candidates for Ams2-binding sites. | true | true | true | true | true | 1,242 |
0 | DISCUSSION | 1 | 6 | [
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | Alternatively, the AACCCT-box may be a binding site for proteins required for association of Ams2 with the promoter. | [
"6",
"7"
] | 116 | 7,665 | 0 | false | Alternatively, the AACCCT-box may be a binding site for proteins required for association of Ams2 with the promoter. | [] | Alternatively, the AACCCT-box may be a binding site for proteins required for association of Ams2 with the promoter. | true | true | true | true | true | 1,242 |
0 | DISCUSSION | 1 | 6 | [
"B6",
"B7"
] | 17,452,352 | pmid-15989979|pmid-1883210|pmid-12408966|pmid-6355483|pmid-519767|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687|pmid-3018512|pmid-4092687 | Elimination of the AACCCT-box from the hht1+ and hhf1+ upstream region results in a marked reduction of promoter activity to the background level, suggesting that the AACCCT-box is essential for the promotion of histone gene transcription. | [
"6",
"7"
] | 239 | 7,666 | 0 | false | Elimination of the AACCCT-box from the hht1+ and hhf1+ upstream region results in a marked reduction of promoter activity to the background level, suggesting that the AACCCT-box is essential for the promotion of histone gene transcription. | [] | Elimination of the AACCCT-box from the hht1+ and hhf1+ upstream region results in a marked reduction of promoter activity to the background level, suggesting that the AACCCT-box is essential for the promotion of histone gene transcription. | true | true | true | true | true | 1,242 |
1 | DISCUSSION | 1 | 42 | [
"B42"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | Ams2 is the first GATA factor reported to be involved in histone transcription. | [
"42"
] | 79 | 7,667 | 0 | false | Ams2 is the first GATA factor reported to be involved in histone transcription. | [] | Ams2 is the first GATA factor reported to be involved in histone transcription. | true | true | true | true | true | 1,243 |
1 | DISCUSSION | 1 | 42 | [
"B42"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | GATA factors are present in all eukaryotes, but it is not yet known whether similar GATA-type transcription factors are commonly utilized in histone gene regulation in different species. | [
"42"
] | 186 | 7,668 | 0 | false | GATA factors are present in all eukaryotes, but it is not yet known whether similar GATA-type transcription factors are commonly utilized in histone gene regulation in different species. | [] | GATA factors are present in all eukaryotes, but it is not yet known whether similar GATA-type transcription factors are commonly utilized in histone gene regulation in different species. | true | true | true | true | true | 1,243 |
1 | DISCUSSION | 1 | 42 | [
"B42"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | Some developmentally regulated GATA factors, such as GATA-4, are referred to as pioneer or decisive factors, because they function as determinants of tissue identity by opening compacted chromatin on tissue-specific promoters to aid access to the promoters by other factors (42). | [
"42"
] | 279 | 7,669 | 1 | false | Some developmentally regulated GATA factors, such as GATA-4, are referred to as pioneer or decisive factors, because they function as determinants of tissue identity by opening compacted chromatin on tissue-specific promoters to aid access to the promoters by other factors. | [
"42"
] | Some developmentally regulated GATA factors, such as GATA-4, are referred to as pioneer or decisive factors, because they function as determinants of tissue identity by opening compacted chromatin on tissue-specific promoters to aid access to the promoters by other factors. | true | true | true | true | true | 1,243 |
1 | DISCUSSION | 1 | 42 | [
"B42"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | To control developmentally programmed transcription, the expression of these molecules is known to be highly restricted during development. | [
"42"
] | 139 | 7,670 | 0 | false | To control developmentally programmed transcription, the expression of these molecules is known to be highly restricted during development. | [] | To control developmentally programmed transcription, the expression of these molecules is known to be highly restricted during development. | true | true | true | true | true | 1,243 |
1 | DISCUSSION | 1 | 42 | [
"B42"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | Similarly, Ams2 protein level is tightly regulated during the cell cycle, peaking at S-phase. | [
"42"
] | 93 | 7,671 | 0 | false | Similarly, Ams2 protein level is tightly regulated during the cell cycle, peaking at S-phase. | [] | Similarly, Ams2 protein level is tightly regulated during the cell cycle, peaking at S-phase. | true | true | true | true | true | 1,243 |
1 | DISCUSSION | 1 | 42 | [
"B42"
] | 17,452,352 | pmid-3708685|pmid-15989979|pmid-12370293|pmid-3815518|pmid-3046933|pmid-15989979|pmid-6751560|pmid-6313932|pmid-3518945|pmid-11864602 | Thus, Ams2 may be involved in the first remodeling step of nucleosomes on the histone promoters. | [
"42"
] | 96 | 7,672 | 0 | false | Thus, Ams2 may be involved in the first remodeling step of nucleosomes on the histone promoters. | [] | Thus, Ams2 may be involved in the first remodeling step of nucleosomes on the histone promoters. | true | true | true | true | true | 1,243 |
2 | DISCUSSION | 1 | 19 | [
"B19"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | We also found that the fission yeast HIRA proteins, Hip1 and Slm9, down-regulate the basal levels of H3 and H4 gene expression. | [
"19"
] | 127 | 7,673 | 0 | false | We also found that the fission yeast HIRA proteins, Hip1 and Slm9, down-regulate the basal levels of H3 and H4 gene expression. | [] | We also found that the fission yeast HIRA proteins, Hip1 and Slm9, down-regulate the basal levels of H3 and H4 gene expression. | true | true | true | true | true | 1,244 |
2 | DISCUSSION | 1 | 19 | [
"B19"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | The effect on derepression of the histone transcription by HIRA-depletion was greater in cells at G2-phase than at S-phase (Figure 7), consistent with the previous report that HIRA functions in repressing histone transcription outside S-phase (19). | [
"19"
] | 248 | 7,674 | 1 | false | The effect on derepression of the histone transcription by HIRA-depletion was greater in cells at G2-phase than at S-phase (Figure 7), consistent with the previous report that HIRA functions in repressing histone transcription outside S-phase. | [
"19"
] | The effect on derepression of the histone transcription by HIRA-depletion was greater in cells at G2-phase than at S-phase (Figure 7), consistent with the previous report that HIRA functions in repressing histone transcription outside S-phase. | true | true | true | true | true | 1,244 |
2 | DISCUSSION | 1 | 19 | [
"B19"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | As the levels of transcription of core histones were increased reproducibly at S-phase in both Hip1-null and Slm9-null cells, the cell cycle-dependent expression seems to be mediated through not only repression of the expression outside S-phase but also by positive activation at S-phase. | [
"19"
] | 288 | 7,675 | 0 | false | As the levels of transcription of core histones were increased reproducibly at S-phase in both Hip1-null and Slm9-null cells, the cell cycle-dependent expression seems to be mediated through not only repression of the expression outside S-phase but also by positive activation at S-phase. | [] | As the levels of transcription of core histones were increased reproducibly at S-phase in both Hip1-null and Slm9-null cells, the cell cycle-dependent expression seems to be mediated through not only repression of the expression outside S-phase but also by positive activation at S-phase. | true | true | true | true | true | 1,244 |
2 | DISCUSSION | 1 | 19 | [
"B19"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | In addition, it should be noted that, in Ams2-deficient cells, the levels of histone transcripts became constant across the cell cycle including S-phase. | [
"19"
] | 153 | 7,676 | 0 | false | In addition, it should be noted that, in Ams2-deficient cells, the levels of histone transcripts became constant across the cell cycle including S-phase. | [] | In addition, it should be noted that, in Ams2-deficient cells, the levels of histone transcripts became constant across the cell cycle including S-phase. | true | true | true | true | true | 1,244 |
2 | DISCUSSION | 1 | 19 | [
"B19"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | These observations might be explained by regulation of histone gene transcription by a combination of Ams2-dependent up-regulation at S-phase and non-periodic basal transcription down-regulated by the HIRA complex throughout the cell cycle. | [
"19"
] | 240 | 7,677 | 0 | false | These observations might be explained by regulation of histone gene transcription by a combination of Ams2-dependent up-regulation at S-phase and non-periodic basal transcription down-regulated by the HIRA complex throughout the cell cycle. | [] | These observations might be explained by regulation of histone gene transcription by a combination of Ams2-dependent up-regulation at S-phase and non-periodic basal transcription down-regulated by the HIRA complex throughout the cell cycle. | true | true | true | true | true | 1,244 |
2 | DISCUSSION | 1 | 19 | [
"B19"
] | 17,452,352 | pmid-15989979|pmid-8417331|pmid-1406694|pmid-8417331|pmid-9001207|pmid-10835386|pmid-15121850|pmid-14718166|pmid-12370293|pmid-15121850 | HIRA-depletion predominantly affects the repression of hht2+ and hhf2+ genes in copy-2, which show periodic expression with low amplitude. | [
"19"
] | 138 | 7,678 | 0 | false | HIRA-depletion predominantly affects the repression of hht2+ and hhf2+ genes in copy-2, which show periodic expression with low amplitude. | [] | HIRA-depletion predominantly affects the repression of hht2+ and hhf2+ genes in copy-2, which show periodic expression with low amplitude. | true | true | true | true | true | 1,244 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | In this study, we clarified the transcriptional properties of individual histone H3 and H4 genes during the cell cycle. | [
"43"
] | 119 | 7,679 | 0 | false | In this study, we clarified the transcriptional properties of individual histone H3 and H4 genes during the cell cycle. | [] | In this study, we clarified the transcriptional properties of individual histone H3 and H4 genes during the cell cycle. | true | true | true | true | true | 1,245 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | Copy-1 (hht1+ and hhf1+) and copy-3 (hht3+ and hhf3+) genes are predominantly transcribed in S-phase in wild-type cells. | [
"43"
] | 120 | 7,680 | 0 | false | Copy-1 (hht1+ and hhf1+) and copy-3 (hht3+ and hhf3+) genes are predominantly transcribed in S-phase in wild-type cells. | [] | Copy-1 (hht1+ and hhf1+) and copy-3 genes are predominantly transcribed in S-phase in wild-type cells. | true | true | true | true | true | 1,245 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | In contrast, copy-2 (hht2+ and hhf2+) genes are transcribed throughout the cell cycle with relatively high levels of basal expression. | [
"43"
] | 134 | 7,681 | 0 | false | In contrast, copy-2 (hht2+ and hhf2+) genes are transcribed throughout the cell cycle with relatively high levels of basal expression. | [] | In contrast, copy-2 (hht2+ and hhf2+) genes are transcribed throughout the cell cycle with relatively high levels of basal expression. | true | true | true | true | true | 1,245 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | We also demonstrated the existence of a feedback mechanism(s) differently up-regulating the reiterated histone H3-H4 gene pairs in Ams2-deficient cells. | [
"43"
] | 152 | 7,682 | 0 | false | We also demonstrated the existence of a feedback mechanism(s) differently up-regulating the reiterated histone H3-H4 gene pairs in Ams2-deficient cells. | [] | We also demonstrated the existence of a feedback mechanism(s) differently up-regulating the reiterated histone H3-H4 gene pairs in Ams2-deficient cells. | true | true | true | true | true | 1,245 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | Ams2 is dispensable for cell viability, although S-phase-specific histone activation is severely compromised in such cells, presumably because non-periodic, basal histone transcription remains and is up-regulated in Ams2-null cells (Figures 1 and 4). | [
"43"
] | 250 | 7,683 | 0 | false | Ams2 is dispensable for cell viability, although S-phase-specific histone activation is severely compromised in such cells, presumably because non-periodic, basal histone transcription remains and is up-regulated in Ams2-null cells (Figures 1 and 4). | [] | Ams2 is dispensable for cell viability, although S-phase-specific histone activation is severely compromised in such cells, presumably because non-periodic, basal histone transcription remains and is up-regulated in Ams2-null cells. | true | true | true | true | true | 1,245 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | The majority of Ams2-independent, non-periodic transcripts of histone H3 and H4 genes are likely supplied by hht2+ and hhf2+ genes in copy-2; copy-2 genes are expressed outside S-phase at relatively high levels in wild-type cells and are up-regulated in Δams2 cells (Figures 5 and 6). | [
"43"
] | 284 | 7,684 | 0 | false | The majority of Ams2-independent, non-periodic transcripts of histone H3 and H4 genes are likely supplied by hht2+ and hhf2+ genes in copy-2; copy-2 genes are expressed outside S-phase at relatively high levels in wild-type cells and are up-regulated in Δams2 cells (Figures 5 and 6). | [] | The majority of Ams2-independent, non-periodic transcripts of histone H3 and H4 genes are likely supplied by hht2+ and hhf2+ genes in copy-2; copy-2 genes are expressed outside S-phase at relatively high levels in wild-type cells and are up-regulated in Δams2 cells (Figures 5 and 6). | true | true | true | true | true | 1,245 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | These observations are consistent with the finding that Ams2-deletion mutants require copy-2 genes for cell viability (Figure S3). | [
"43"
] | 130 | 7,685 | 0 | false | These observations are consistent with the finding that Ams2-deletion mutants require copy-2 genes for cell viability (Figure S3). | [] | These observations are consistent with the finding that Ams2-deletion mutants require copy-2 genes for cell viability. | true | true | true | true | true | 1,245 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | It has been reported that cells retaining only copy-1 genes (1 only) are notably sensitive to thiabendazole, a spindle poison, and cells retaining only copy-3 genes (3 only) show a temperature sensitive growth defect at 36°C. | [
"43"
] | 225 | 7,686 | 0 | false | It has been reported that cells retaining only copy-1 genes (1 only) are notably sensitive to thiabendazole, a spindle poison, and cells retaining only copy-3 genes (3 only) show a temperature sensitive growth defect at 36°C. | [] | It has been reported that cells retaining only copy-1 genes (1 only) are notably sensitive to thiabendazole, a spindle poison, and cells retaining only copy-3 genes show a temperature sensitive growth defect at 36°C. | true | true | true | true | true | 1,245 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | In contrast, cells retaining only copy-2 genes (2 only) showed no such sensitivities to thiabendazole or elevated temperature (43). | [
"43"
] | 131 | 7,687 | 1 | false | In contrast, cells retaining only copy-2 genes (2 only) showed no such sensitivities to thiabendazole or elevated temperature. | [
"43"
] | In contrast, cells retaining only copy-2 genes (2 only) showed no such sensitivities to thiabendazole or elevated temperature. | true | true | true | true | true | 1,245 |
3 | DISCUSSION | 1 | 43 | [
"B43"
] | 17,452,352 | pmid-16571659|pmid-16571659|pmid-16267050|pmid-16571659|pmid-16267050|pmid-16571659|pmid-12086617|pmid-16267050|pmid-15006351|pmid-16571659|pmid-14561399 | Non-periodic basal transcription of H3 and H4 genes, which is mainly from the copy-2 loci, may be an important component of the feedback regulation when cells encounter stresses that somehow perturb the normal progression of the cell cycle. | [
"43"
] | 240 | 7,688 | 0 | false | Non-periodic basal transcription of H3 and H4 genes, which is mainly from the copy-2 loci, may be an important component of the feedback regulation when cells encounter stresses that somehow perturb the normal progression of the cell cycle. | [] | Non-periodic basal transcription of H3 and H4 genes, which is mainly from the copy-2 loci, may be an important component of the feedback regulation when cells encounter stresses that somehow perturb the normal progression of the cell cycle. | true | true | true | true | true | 1,245 |
4 | DISCUSSION | 1 | 44 | [
"B44",
"B45",
"B46"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | Among the three copies, copy-2 genes were the most up-regulated responded to the elimination of histone activation in S-phase (Figure 5B). | [
"44",
"45",
"46"
] | 138 | 7,689 | 0 | false | Among the three copies, copy-2 genes were the most up-regulated responded to the elimination of histone activation in S-phase (Figure 5B). | [] | Among the three copies, copy-2 genes were the most up-regulated responded to the elimination of histone activation in S-phase (Figure 5B). | true | true | true | true | true | 1,246 |
4 | DISCUSSION | 1 | 44 | [
"B44",
"B45",
"B46"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | The feedback up-regulation of copy-2 and copy-3 but not copy-1 genes were detected responded to the reduction in copy number of H3-H4 pairs by gene disruption (Figure 5D). | [
"44",
"45",
"46"
] | 171 | 7,690 | 0 | false | The feedback up-regulation of copy-2 and copy-3 but not copy-1 genes were detected responded to the reduction in copy number of H3-H4 pairs by gene disruption (Figure 5D). | [] | The feedback up-regulation of copy-2 and copy-3 but not copy-1 genes were detected responded to the reduction in copy number of H3-H4 pairs by gene disruption (Figure 5D). | true | true | true | true | true | 1,246 |
4 | DISCUSSION | 1 | 44 | [
"B44",
"B45",
"B46"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | During G2-phase in the normal cell cycle, the basal levels of the copy-3 gene transcripts were up-regulated in Ams2 shut-off cells as well as those of copy-1 and copy-2 genes (Figure 6). | [
"44",
"45",
"46"
] | 186 | 7,691 | 0 | false | During G2-phase in the normal cell cycle, the basal levels of the copy-3 gene transcripts were up-regulated in Ams2 shut-off cells as well as those of copy-1 and copy-2 genes (Figure 6). | [] | During G2-phase in the normal cell cycle, the basal levels of the copy-3 gene transcripts were up-regulated in Ams2 shut-off cells as well as those of copy-1 and copy-2 genes (Figure 6). | true | true | true | true | true | 1,246 |
4 | DISCUSSION | 1 | 44 | [
"B44",
"B45",
"B46"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | However, following release of Ams2-null cells from HU block, up-regulation of copy-3 genes was not detected in G2-phase (Figure 7). | [
"44",
"45",
"46"
] | 131 | 7,692 | 0 | false | However, following release of Ams2-null cells from HU block, up-regulation of copy-3 genes was not detected in G2-phase (Figure 7). | [] | However, following release of Ams2-null cells from HU block, up-regulation of copy-3 genes was not detected in G2-phase (Figure 7). | true | true | true | true | true | 1,246 |
4 | DISCUSSION | 1 | 44 | [
"B44",
"B45",
"B46"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | The feedback response of histone transcripts may be regulated differently according to changes in rates of DNA synthesis. | [
"44",
"45",
"46"
] | 121 | 7,693 | 0 | false | The feedback response of histone transcripts may be regulated differently according to changes in rates of DNA synthesis. | [] | The feedback response of histone transcripts may be regulated differently according to changes in rates of DNA synthesis. | true | true | true | true | true | 1,246 |
4 | DISCUSSION | 1 | 44 | [
"B44",
"B45",
"B46"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | These observations may indicate the existence of a variety of feedback modes for histone gene regulations. | [
"44",
"45",
"46"
] | 106 | 7,694 | 0 | false | These observations may indicate the existence of a variety of feedback modes for histone gene regulations. | [] | These observations may indicate the existence of a variety of feedback modes for histone gene regulations. | true | true | true | true | true | 1,246 |
4 | DISCUSSION | 1 | 44 | [
"B44",
"B45",
"B46"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | In budding yeast, deletion of one pair of H3-H4 genes does not affect the expression of other pairs of H3-H4 genes (44), whereas the levels of histone H2A-H2B gene transcripts (HTA1-HTB1 and HTA2-HTB2 gene pairs) are controlled by either up-regulation of HTA1-HTB1 transcription (45) or direct amplification of HTA2-HTB2... | [
"44",
"45",
"46"
] | 365 | 7,695 | 1 | false | In budding yeast, deletion of one pair of H3-H4 genes does not affect the expression of other pairs of H3-H4 genes, whereas the levels of histone H2A-H2B gene transcripts (HTA1-HTB1 and HTA2-HTB2 gene pairs) are controlled by either up-regulation of HTA1-HTB1 transcription or direct amplification of HTA2-HTB2 genes by ... | [
"44",
"45",
"46"
] | In budding yeast, deletion of one pair of H3-H4 genes does not affect the expression of other pairs of H3-H4 genes, whereas the levels of histone H2A-H2B gene transcripts (HTA1-HTB1 and HTA2-HTB2 gene pairs) are controlled by either up-regulation of HTA1-HTB1 transcription or direct amplification of HTA2-HTB2 genes by ... | true | true | true | true | true | 1,246 |
4 | DISCUSSION | 1 | 44 | [
"B44",
"B45",
"B46"
] | 17,452,352 | pmid-12535531|pmid-12851470|pmid-12851470|pmid-12535531|pmid-12535531|pmid-3280973|pmid-2199321|pmid-17066037 | For the maintenance of genomic integrity, eukaryotic cells probably utilize several different mechanisms to compensate for histone dosage effects when perturbed. | [
"44",
"45",
"46"
] | 161 | 7,696 | 0 | false | For the maintenance of genomic integrity, eukaryotic cells probably utilize several different mechanisms to compensate for histone dosage effects when perturbed. | [] | For the maintenance of genomic integrity, eukaryotic cells probably utilize several different mechanisms to compensate for histone dosage effects when perturbed. | true | true | true | true | true | 1,246 |
5 | DISCUSSION | 0 | null | null | 17,452,352 | null | One intriguing property of the divergent transcription of H3-H4 gene pairs is the asymmetric production of H3-H4 transcripts from copy-2 genes. | null | 143 | 7,697 | 0 | false | null | null | One intriguing property of the divergent transcription of H3-H4 gene pairs is the asymmetric production of H3-H4 transcripts from copy-2 genes. | true | true | true | true | true | 1,247 |
5 | DISCUSSION | 0 | null | null | 17,452,352 | null | The hht2+ transcript is present throughout the cell cycle, while the hhf2+ transcript is cell cycle regulated. | null | 110 | 7,698 | 0 | false | null | null | The hht2+ transcript is present throughout the cell cycle, while the hhf2+ transcript is cell cycle regulated. | true | true | true | true | true | 1,247 |
5 | DISCUSSION | 0 | null | null | 17,452,352 | null | As both hht2+ | null | 13 | 7,699 | 0 | false | null | null | As both hht2+ | true | true | false | true | false | 1,247 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.