Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
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2
INTRODUCTION
0
null
null
21,123,694
null
Performance on non-LBL exam questions was also compared.
null
56
36,816
0
false
null
null
Performance on non-LBL exam questions was also compared.
true
true
true
true
true
6,315
0
DISCUSSION
0
null
null
21,123,694
NA|pmid-16341257|NA|pmid-17548875|NA|pmid-19487500
Our data demonstrate inclusion of LBLs that shifted presentation of new material from lecture to preclass assignments but did not require instructor review, coupled with related participatory exercises in class, resulted in significant increases in student learning gains in a large introductory biology course.
null
311
36,817
0
false
null
null
Our data demonstrate inclusion of LBLs that shifted presentation of new material from lecture to preclass assignments but did not require instructor review, coupled with related participatory exercises in class, resulted in significant increases in student learning gains in a large introductory biology course.
true
true
true
true
true
6,316
0
DISCUSSION
0
null
null
21,123,694
NA|pmid-16341257|NA|pmid-17548875|NA|pmid-19487500
Our findings also indicate that the learning gains associated with LBLs did not come at the expense of reduced learning outcomes on non-LBL material.
null
149
36,818
0
false
null
null
Our findings also indicate that the learning gains associated with LBLs did not come at the expense of reduced learning outcomes on non-LBL material.
true
true
true
true
true
6,316
0
DISCUSSION
0
null
null
21,123,694
NA|pmid-16341257|NA|pmid-17548875|NA|pmid-19487500
The combination of increased exam performance on LBL-related topics and the high level of student satisfaction encourages us to continue their use in our class.
null
160
36,819
0
false
null
null
The combination of increased exam performance on LBL-related topics and the high level of student satisfaction encourages us to continue their use in our class.
true
true
true
true
true
6,316
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
The LBLs in 2009 were used for only a small number of topics, while the rest were taught with the same strategies used in the previous years.
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
141
36,820
0
false
The LBLs in 2009 were used for only a small number of topics, while the rest were taught with the same strategies used in the previous years.
[]
The LBLs in 2009 were used for only a small number of topics, while the rest were taught with the same strategies used in the previous years.
true
true
true
true
true
6,317
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
This allowed us to examine the effectiveness of LBLs, embedded in the same overall class environment.
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
101
36,821
0
false
This allowed us to examine the effectiveness of LBLs, embedded in the same overall class environment.
[]
This allowed us to examine the effectiveness of LBLs, embedded in the same overall class environment.
true
true
true
true
true
6,317
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
While it is common to assess learning gains by comparing student performance on identical questions before and after a new teaching strategy, these are most often administered as ungraded surveys at the beginning and the end of a class (Metz, 2008; Perry et al., 2008; Scholer and Hatton, 2008).
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
295
36,822
0
false
While it is common to assess learning gains by comparing student performance on identical questions before and after a new teaching strategy, these are most often administered as ungraded surveys at the beginning and the end of a class.
[ "Metz, 2008; Perry et al., 2008; Scholer and Hatton, 2008" ]
While it is common to assess learning gains by comparing student performance on identical questions before and after a new teaching strategy, these are most often administered as ungraded surveys at the beginning and the end of a class.
true
true
true
true
true
6,317
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
This was not possible because our study was conducted over three years with different classes.
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
94
36,823
0
false
This was not possible because our study was conducted over three years with different classes.
[]
This was not possible because our study was conducted over three years with different classes.
true
true
true
true
true
6,317
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
In addition, we wanted to evaluate both LBL and non-LBL course related learning outcomes under conditions where the performance expectations and motivation were consistent, so comparisons were all based on performance on exam questions.
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
236
36,824
0
false
In addition, we wanted to evaluate both LBL and non-LBL course related learning outcomes under conditions where the performance expectations and motivation were consistent, so comparisons were all based on performance on exam questions.
[]
In addition, we wanted to evaluate both LBL and non-LBL course related learning outcomes under conditions where the performance expectations and motivation were consistent, so comparisons were all based on performance on exam questions.
true
true
true
true
true
6,317
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
Our standard practice of posting answer keys to all exams precluded extensive use of identical questions from year to year.
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
123
36,825
0
false
Our standard practice of posting answer keys to all exams precluded extensive use of identical questions from year to year.
[]
Our standard practice of posting answer keys to all exams precluded extensive use of identical questions from year to year.
true
true
true
true
true
6,317
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
Therefore only one question pair was identical and the other five were isomorphic, closely matched by topic, presentation, and Bloom's level (Smith et al., 2009).
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
162
36,826
0
false
Therefore only one question pair was identical and the other five were isomorphic, closely matched by topic, presentation, and Bloom's level.
[ "Smith et al., 2009" ]
Therefore only one question pair was identical and the other five were isomorphic, closely matched by topic, presentation, and Bloom's level.
true
true
true
true
true
6,317
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
A post hoc analysis also showed that all questions in each pair were well matched in terms of their ability to discriminate stronger from weaker students based on PBS values of 0.3 or higher (Ding et al., 2006).
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
211
36,827
0
false
A post hoc analysis also showed that all questions in each pair were well matched in terms of their ability to discriminate stronger from weaker students based on PBS values of 0.3 or higher.
[ "Ding et al., 2006" ]
A post hoc analysis also showed that all questions in each pair were well matched in terms of their ability to discriminate stronger from weaker students based on PBS values of 0.3 or higher.
true
true
true
true
true
6,317
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
This strongly suggests that the large mean increase in performance on the matched final exam question pairs that we report in this study reflects increases in student learning associated with the LBLs.
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
201
36,828
0
false
This strongly suggests that the large mean increase in performance on the matched final exam question pairs that we report in this study reflects increases in student learning associated with the LBLs.
[]
This strongly suggests that the large mean increase in performance on the matched final exam question pairs that we report in this study reflects increases in student learning associated with the LBLs.
true
true
true
true
true
6,317
1
DISCUSSION
1
Metz, 2008
[ "B20", "B27", "B30", "B33", "B10" ]
21,123,694
NA|pmid-19047506|pmid-20046908|NA|NA|NA|NA|NA|NA|pmid-18765754|pmid-18519610|NA|pmid-19119232|NA
Further support for this conclusion is that there was little or no increase in the performance on non-LBL exam questions between 2009 and the previous years, and the cohorts in all years were similar in terms of their demographics and preclass academic indicators.
[ "Metz, 2008", "Perry ", "Scholer and Hatton, 2008", "Smith ", "Ding " ]
264
36,829
0
false
Further support for this conclusion is that there was little or no increase in the performance on non-LBL exam questions between 2009 and the previous years, and the cohorts in all years were similar in terms of their demographics and preclass academic indicators.
[]
Further support for this conclusion is that there was little or no increase in the performance on non-LBL exam questions between 2009 and the previous years, and the cohorts in all years were similar in terms of their demographics and preclass academic indicators.
true
true
true
true
true
6,317
2
DISCUSSION
0
null
null
21,123,694
null
Our introductory biology course covers material from DNA to organisms in 10 wk.
null
79
36,830
0
false
null
null
Our introductory biology course covers material from DNA to organisms in 10 wk.
true
true
true
true
true
6,318
2
DISCUSSION
0
null
null
21,123,694
null
The goal of moving material out of lecture was not to increase the amount of material covered, as the content is already broad and challenging.
null
143
36,831
0
false
null
null
The goal of moving material out of lecture was not to increase the amount of material covered, as the content is already broad and challenging.
true
true
true
true
true
6,318
2
DISCUSSION
0
null
null
21,123,694
null
Instead, we selected topics where the basic knowledge was explained well in the textbook and developed preclass assignments that guided students through the reading and interpretation of diagram/figures.
null
203
36,832
0
false
null
null
Instead, we selected topics where the basic knowledge was explained well in the textbook and developed preclass assignments that guided students through the reading and interpretation of diagram/figures.
true
true
true
true
true
6,318
2
DISCUSSION
0
null
null
21,123,694
null
The LBL-related questions associated with the largest performance increases were multiple alleles (comprehension level) and nuclear transport (application level).
null
162
36,833
0
false
null
null
The LBL-related questions associated with the largest performance increases were multiple alleles (comprehension level) and nuclear transport (application level).
true
true
true
true
true
6,318
2
DISCUSSION
0
null
null
21,123,694
null
Historically these have been difficult topics for students, and modifications in presentation of the material in lecture over multiple years had resulted in little change in understanding.
null
188
36,834
0
false
null
null
Historically these have been difficult topics for students, and modifications in presentation of the material in lecture over multiple years had resulted in little change in understanding.
true
true
true
true
true
6,318
2
DISCUSSION
0
null
null
21,123,694
null
The only LBL-related question (plasmids) that did not result in a significant increase in performance was one that the majority (80%) of students got correct before LBLs were introduced, consistent with the interpretation that presentation of this material in lecture was already quite effective.
null
296
36,835
0
false
null
null
The only LBL-related question (plasmids) that did not result in a significant increase in performance was one that the majority (80%) of students got correct before LBLs were introduced, consistent with the interpretation that presentation of this material in lecture was already quite effective.
true
true
true
true
true
6,318
2
DISCUSSION
0
null
null
21,123,694
null
Our data thus indicate that the LBL strategy is most effective for teaching core biological concepts that are challenging for students to learn in a traditional lecture format.
null
176
36,836
0
false
null
null
Our data thus indicate that the LBL strategy is most effective for teaching core biological concepts that are challenging for students to learn in a traditional lecture format.
true
true
true
true
true
6,318
2
DISCUSSION
0
null
null
21,123,694
null
The increase in performance on both comprehension- and application-level questions suggests that exposure to new material before class along with revisiting this material during the more in-depth exploration of the core concepts in class contributes to the learning gains.
null
272
36,837
0
false
null
null
The increase in performance on both comprehension- and application-level questions suggests that exposure to new material before class along with revisiting this material during the more in-depth exploration of the core concepts in class contributes to the learning gains.
true
true
true
true
true
6,318
3
DISCUSSION
1
Walvoord and Anderson, 1998
[ "B34", "B6", "B17", "B16", "B2", "B9" ]
21,123,694
NA|NA|NA|NA|pmid-16344858|NA
Previous studies have used homework assignments similar to our worksheets and online video lectures to introduce students to new material before class (Walvoord and Anderson, 1998; Collard et al., 2002; Klionsky, 2002; Keefe, 2003; Allen and Tanner, 2005; Day and Foley, 2006).
[ "Walvoord and Anderson, 1998", "Collard ", "Klionsky, 2002", "Keefe, 2003", "Allen and Tanner, 2005", "Day and Foley, 2006" ]
277
36,838
0
false
Previous studies have used homework assignments similar to our worksheets and online video lectures to introduce students to new material before class.
[ "Walvoord and Anderson, 1998; Collard et al., 2002; Klionsky, 2002; Keefe, 2003; Allen and Tanner, 2005; Day and Foley, 2006" ]
Previous studies have used homework assignments similar to our worksheets and online video lectures to introduce students to new material before class.
true
true
true
true
true
6,319
3
DISCUSSION
1
Walvoord and Anderson, 1998
[ "B34", "B6", "B17", "B16", "B2", "B9" ]
21,123,694
NA|NA|NA|NA|pmid-16344858|NA
However, there is little information regarding the comparative effectiveness of these methods on student learning.
[ "Walvoord and Anderson, 1998", "Collard ", "Klionsky, 2002", "Keefe, 2003", "Allen and Tanner, 2005", "Day and Foley, 2006" ]
114
36,839
0
false
However, there is little information regarding the comparative effectiveness of these methods on student learning.
[]
However, there is little information regarding the comparative effectiveness of these methods on student learning.
true
true
true
true
true
6,319
3
DISCUSSION
1
Walvoord and Anderson, 1998
[ "B34", "B6", "B17", "B16", "B2", "B9" ]
21,123,694
NA|NA|NA|NA|pmid-16344858|NA
In our study, we found no difference in exam performance between students who completed a worksheet LBL and those who viewed a narrated video LBL on the same topic.
[ "Walvoord and Anderson, 1998", "Collard ", "Klionsky, 2002", "Keefe, 2003", "Allen and Tanner, 2005", "Day and Foley, 2006" ]
164
36,840
0
false
In our study, we found no difference in exam performance between students who completed a worksheet LBL and those who viewed a narrated video LBL on the same topic.
[]
In our study, we found no difference in exam performance between students who completed a worksheet LBL and those who viewed a narrated video LBL on the same topic.
true
true
true
true
true
6,319
3
DISCUSSION
1
Walvoord and Anderson, 1998
[ "B34", "B6", "B17", "B16", "B2", "B9" ]
21,123,694
NA|NA|NA|NA|pmid-16344858|NA
This was somewhat surprising because we predicted the worksheet assignments would be more effective as they required more active participation including writing answers to questions and/or making drawings.
[ "Walvoord and Anderson, 1998", "Collard ", "Klionsky, 2002", "Keefe, 2003", "Allen and Tanner, 2005", "Day and Foley, 2006" ]
205
36,841
0
false
This was somewhat surprising because we predicted the worksheet assignments would be more effective as they required more active participation including writing answers to questions and/or making drawings.
[]
This was somewhat surprising because we predicted the worksheet assignments would be more effective as they required more active participation including writing answers to questions and/or making drawings.
true
true
true
true
true
6,319
3
DISCUSSION
1
Walvoord and Anderson, 1998
[ "B34", "B6", "B17", "B16", "B2", "B9" ]
21,123,694
NA|NA|NA|NA|pmid-16344858|NA
We also saw no difference in learning between those who completed the cut-out and drawing versions of the third LBL assignment, again contrary to our prediction that actually making a model would be more effective in reinforcing learning than analysis of a drawing.
[ "Walvoord and Anderson, 1998", "Collard ", "Klionsky, 2002", "Keefe, 2003", "Allen and Tanner, 2005", "Day and Foley, 2006" ]
265
36,842
0
false
We also saw no difference in learning between those who completed the cut-out and drawing versions of the third LBL assignment, again contrary to our prediction that actually making a model would be more effective in reinforcing learning than analysis of a drawing.
[]
We also saw no difference in learning between those who completed the cut-out and drawing versions of the third LBL assignment, again contrary to our prediction that actually making a model would be more effective in reinforcing learning than analysis of a drawing.
true
true
true
true
true
6,319
4
DISCUSSION
1
Riffell and Sibley, 2005
[ "B28" ]
21,123,694
NA
The data demonstrate that both methods of preclass exposure to the material are equally effective in producing learning gains when coupled with the same in-class activities.
[ "Riffell and Sibley, 2005" ]
173
36,843
0
false
The data demonstrate that both methods of preclass exposure to the material are equally effective in producing learning gains when coupled with the same in-class activities.
[]
The data demonstrate that both methods of preclass exposure to the material are equally effective in producing learning gains when coupled with the same in-class activities.
true
true
true
true
true
6,320
4
DISCUSSION
1
Riffell and Sibley, 2005
[ "B28" ]
21,123,694
NA
However, we were unable to determine what percentage of the learning gains were associated with the preclass exposure as opposed to the in-class activity, as the combination was part of the experimental design.
[ "Riffell and Sibley, 2005" ]
210
36,844
0
false
However, we were unable to determine what percentage of the learning gains were associated with the preclass exposure as opposed to the in-class activity, as the combination was part of the experimental design.
[]
However, we were unable to determine what percentage of the learning gains were associated with the preclass exposure as opposed to the in-class activity, as the combination was part of the experimental design.
true
true
true
true
true
6,320
4
DISCUSSION
1
Riffell and Sibley, 2005
[ "B28" ]
21,123,694
NA
It would be interesting to explore the relative contributions in our setting because a previous study showed that active-learning exercises coupled with online activities were more effective than active exercises alone (Riffell and Sibley, 2005).
[ "Riffell and Sibley, 2005" ]
246
36,845
1
false
It would be interesting to explore the relative contributions in our setting because a previous study showed that active-learning exercises coupled with online activities were more effective than active exercises alone.
[ "Riffell and Sibley, 2005" ]
It would be interesting to explore the relative contributions in our setting because a previous study showed that active-learning exercises coupled with online activities were more effective than active exercises alone.
true
true
true
true
true
6,320
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
In large classes like ours, collection and assessment of assignments on paper is not feasible with limited administrative support.
[ "Schaeffer ", "Allain and Williams, 2006" ]
130
36,846
0
false
In large classes like ours, collection and assessment of assignments on paper is not feasible with limited administrative support.
[]
In large classes like ours, collection and assessment of assignments on paper is not feasible with limited administrative support.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
Therefore, we chose to have all LBL assignments distributed and submitted electronically.
[ "Schaeffer ", "Allain and Williams, 2006" ]
89
36,847
0
false
Therefore, we chose to have all LBL assignments distributed and submitted electronically.
[]
Therefore, we chose to have all LBL assignments distributed and submitted electronically.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
Online assignments can be submitted in multiple formats, including Word documents or online forms (Schaeffer et al., 2001; Allain and Williams, 2006).
[ "Schaeffer ", "Allain and Williams, 2006" ]
150
36,848
0
false
Online assignments can be submitted in multiple formats, including Word documents or online forms.
[ "Schaeffer et al., 2001; Allain and Williams, 2006" ]
Online assignments can be submitted in multiple formats, including Word documents or online forms.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
Our submission procedure required uploading of a digital image to our class website drop box, so we were able to assess whether students completed drawings and/or made cut-out models.
[ "Schaeffer ", "Allain and Williams, 2006" ]
183
36,849
0
false
Our submission procedure required uploading of a digital image to our class website drop box, so we were able to assess whether students completed drawings and/or made cut-out models.
[]
Our submission procedure required uploading of a digital image to our class website drop box, so we were able to assess whether students completed drawings and/or made cut-out models.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
More than 90% of the students were able to accomplish this task by scanning or photographing their completed worksheets.
[ "Schaeffer ", "Allain and Williams, 2006" ]
120
36,850
0
false
More than 90% of the students were able to accomplish this task by scanning or photographing their completed worksheets.
[]
More than 90% of the students were able to accomplish this task by scanning or photographing their completed worksheets.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
A small percentage of students uploaded Word documents.
[ "Schaeffer ", "Allain and Williams, 2006" ]
55
36,851
0
false
A small percentage of students uploaded Word documents.
[]
A small percentage of students uploaded Word documents.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
In a postclass survey approximately 5% of the students reported dissatisfaction with the submission procedure, including difficulty in accessing a digital camera or scanner.
[ "Schaeffer ", "Allain and Williams, 2006" ]
173
36,852
0
false
In a postclass survey approximately 5% of the students reported dissatisfaction with the submission procedure, including difficulty in accessing a digital camera or scanner.
[]
In a postclass survey approximately 5% of the students reported dissatisfaction with the submission procedure, including difficulty in accessing a digital camera or scanner.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
Virtually all of our students have cell phones with digital cameras, the more recent versions of which were used by a number of students to produce adequate images of their assignments.
[ "Schaeffer ", "Allain and Williams, 2006" ]
185
36,853
0
false
Virtually all of our students have cell phones with digital cameras, the more recent versions of which were used by a number of students to produce adequate images of their assignments.
[]
Virtually all of our students have cell phones with digital cameras, the more recent versions of which were used by a number of students to produce adequate images of their assignments.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
In coming years, high-resolution cell phone cameras will provide most students with a relatively simple method to create digital images of their completed assignments.
[ "Schaeffer ", "Allain and Williams, 2006" ]
167
36,854
0
false
In coming years, high-resolution cell phone cameras will provide most students with a relatively simple method to create digital images of their completed assignments.
[]
In coming years, high-resolution cell phone cameras will provide most students with a relatively simple method to create digital images of their completed assignments.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
It is also worth noting that web-based reading quizzes are relatively simple to set-up and administer through readily available online course management systems.
[ "Schaeffer ", "Allain and Williams, 2006" ]
161
36,855
0
false
It is also worth noting that web-based reading quizzes are relatively simple to set-up and administer through readily available online course management systems.
[]
It is also worth noting that web-based reading quizzes are relatively simple to set-up and administer through readily available online course management systems.
true
true
true
true
true
6,321
5
DISCUSSION
1
Schaeffer
[ "B29", "B1" ]
21,123,694
NA|NA
Although we hypothesize that students learn more when they have to write out something by hand, it would be interesting to test the relative efficacy of LBLs with completely electronic reading quizzes.
[ "Schaeffer ", "Allain and Williams, 2006" ]
201
36,856
0
false
Although we hypothesize that students learn more when they have to write out something by hand, it would be interesting to test the relative efficacy of LBLs with completely electronic reading quizzes.
[]
Although we hypothesize that students learn more when they have to write out something by hand, it would be interesting to test the relative efficacy of LBLs with completely electronic reading quizzes.
true
true
true
true
true
6,321
0
DISCUSSION
0
null
null
19,036,721
null
We used a quantitative proteomics approach to thoroughly characterize sterol-dependent membrane proteins in plant plasma membrane preparations.
null
143
36,857
0
false
null
null
We used a quantitative proteomics approach to thoroughly characterize sterol-dependent membrane proteins in plant plasma membrane preparations.
true
true
true
true
true
6,322
0
DISCUSSION
0
null
null
19,036,721
null
Our work is the first study on plant DRM that has been carried out up to date allowing such clear differentiation of sterol-dependent and sterol-independent membrane proteins.
null
175
36,858
0
false
null
null
Our work is the first study on plant DRM that has been carried out up to date allowing such clear differentiation of sterol-dependent and sterol-independent membrane proteins.
true
true
true
true
true
6,322
0
DISCUSSION
0
null
null
19,036,721
null
In addition it reveals novel insights into the concept of the lipid raft model in plants as a dynamic compartment.
null
114
36,859
0
false
null
null
In addition it reveals novel insights into the concept of the lipid raft model in plants as a dynamic compartment.
true
true
true
true
true
6,322
1
DISCUSSION
1
40
[ "r40", "r41" ]
19,036,721
pmid-17493580|pmid-2598927
The precise effect of mβcd on sterols in the plant has not been studied up to date.
[ "40", "41" ]
83
36,860
0
false
The precise effect of mβcd on sterols in the plant has not been studied up to date.
[]
The precise effect of mβcd on sterols in the plant has not been studied up to date.
true
true
true
true
true
6,323
1
DISCUSSION
1
40
[ "r40", "r41" ]
19,036,721
pmid-17493580|pmid-2598927
Therefore, it is well possible that in our experiments the plant lipid rafts were not completely disrupted by the mβcd treatment as mβcd may not have such a strong effect on plant-specific sterols compared with cholesterol as the dominant sterol in mammalian plasma membranes.
[ "40", "41" ]
276
36,861
0
false
Therefore, it is well possible that in our experiments the plant lipid rafts were not completely disrupted by the mβcd treatment as mβcd may not have such a strong effect on plant-specific sterols compared with cholesterol as the dominant sterol in mammalian plasma membranes.
[]
Therefore, it is well possible that in our experiments the plant lipid rafts were not completely disrupted by the mβcd treatment as mβcd may not have such a strong effect on plant-specific sterols compared with cholesterol as the dominant sterol in mammalian plasma membranes.
true
true
true
true
true
6,323
1
DISCUSSION
1
40
[ "r40", "r41" ]
19,036,721
pmid-17493580|pmid-2598927
It has been shown recently that mβcd acts with different efficiencies on different membrane types, requiring vastly different concentrations and incubation times for different mammalian cell types and tissues (40).
[ "40", "41" ]
214
36,862
1
false
It has been shown recently that mβcd acts with different efficiencies on different membrane types, requiring vastly different concentrations and incubation times for different mammalian cell types and tissues.
[ "40" ]
It has been shown recently that mβcd acts with different efficiencies on different membrane types, requiring vastly different concentrations and incubation times for different mammalian cell types and tissues.
true
true
true
true
true
6,323
1
DISCUSSION
1
41
[ "r40", "r41" ]
19,036,721
pmid-17493580|pmid-2598927
It has also been shown on mammalian cells that mβcd removes sterol from the membranes without destroying the bilayer (41).
[ "40", "41" ]
122
36,863
1
false
It has also been shown on mammalian cells that mβcd removes sterol from the membranes without destroying the bilayer.
[ "41" ]
It has also been shown on mammalian cells that mβcd removes sterol from the membranes without destroying the bilayer.
true
true
true
true
true
6,323
2
DISCUSSION
0
null
null
19,036,721
null
Our analysis of sterol composition in the DRM preparations after mβcd treatment of plasma membranes indicates that sterols are indeed being removed under the conditions applied in this study.
null
191
36,864
0
false
null
null
Our analysis of sterol composition in the DRM preparations after mβcd treatment of plasma membranes indicates that sterols are indeed being removed under the conditions applied in this study.
true
true
true
true
true
6,324
2
DISCUSSION
0
null
null
19,036,721
null
We still observed a strong increase in the removal of sterols when increasing the mβcd concentration from 15 to 30 mm, but this effect was different for individual sterol species.
null
179
36,865
0
false
null
null
We still observed a strong increase in the removal of sterols when increasing the mβcd concentration from 15 to 30 mm, but this effect was different for individual sterol species.
true
true
true
true
true
6,324
2
DISCUSSION
0
null
null
19,036,721
null
However, we observed a saturation effect on the efficiency with which proteins are being removed from the plasma membrane by mβcd at concentrations between 15 and 30 mm.
null
169
36,866
0
false
null
null
However, we observed a saturation effect on the efficiency with which proteins are being removed from the plasma membrane by mβcd at concentrations between 15 and 30 mm.
true
true
true
true
true
6,324
2
DISCUSSION
0
null
null
19,036,721
null
The mβcd concentration used for the comparative analysis was 25 mm.
null
67
36,867
0
false
null
null
The mβcd concentration used for the comparative analysis was 25 mm.
true
true
true
true
true
6,324
2
DISCUSSION
0
null
null
19,036,721
null
Thus, it is likely that the mβcd effect on protein was saturated in this study.
null
79
36,868
0
false
null
null
Thus, it is likely that the mβcd effect on protein was saturated in this study.
true
true
true
true
true
6,324
3
DISCUSSION
1
15
[ "r15", "r16" ]
19,036,721
pmid-15618420|pmid-15190066
Typical contaminants and co-purifying proteins in plasma membrane and DRM preparations such as ribosomal proteins, vacuolar ATPase subunits, or transcription initiation factors (15, 16) did not show any differential response to mβcd treatment.
[ "15", "16" ]
243
36,869
0
false
Typical contaminants and co-purifying proteins in plasma membrane and DRM preparations such as ribosomal proteins, vacuolar ATPase subunits, or transcription initiation factors did not show any differential response to mβcd treatment.
[ "15, 16" ]
Typical contaminants and co-purifying proteins in plasma membrane and DRM preparations such as ribosomal proteins, vacuolar ATPase subunits, or transcription initiation factors did not show any differential response to mβcd treatment.
true
true
true
true
true
6,325
3
DISCUSSION
1
15
[ "r15", "r16" ]
19,036,721
pmid-15618420|pmid-15190066
This indicates that the strategy applied here to use depletion of proteins from plasma membranes and DRM by mβcd treatment is a valid means to dissect and characterize the biochemical properties of DRM also in plants.
[ "15", "16" ]
217
36,870
0
false
This indicates that the strategy applied here to use depletion of proteins from plasma membranes and DRM by mβcd treatment is a valid means to dissect and characterize the biochemical properties of DRM also in plants.
[]
This indicates that the strategy applied here to use depletion of proteins from plasma membranes and DRM by mβcd treatment is a valid means to dissect and characterize the biochemical properties of DRM also in plants.
true
true
true
true
true
6,325
3
DISCUSSION
1
15
[ "r15", "r16" ]
19,036,721
pmid-15618420|pmid-15190066
This work is the first detailed global analysis specifically of sterol-rich membrane microdomains in plants, and by its design in reciprocal experiments it allows the precise definition of different categories of proteins in this compartment.
[ "15", "16" ]
242
36,871
0
false
This work is the first detailed global analysis specifically of sterol-rich membrane microdomains in plants, and by its design in reciprocal experiments it allows the precise definition of different categories of proteins in this compartment.
[]
This work is the first detailed global analysis specifically of sterol-rich membrane microdomains in plants, and by its design in reciprocal experiments it allows the precise definition of different categories of proteins in this compartment.
true
true
true
true
true
6,325
4
DISCUSSION
1
42
[ "r42" ]
19,036,721
pmid-17119156
The combination of the analysis of proteins removed from detergent-resistant domain preparations in reciprocal labeling experiments with the subsequent demonstration that these particular proteins are being enriched in the supernatant after pelleting of mβcd-treated membranes is the first evidence in plants that bioche...
[ "42" ]
442
36,872
0
false
The combination of the analysis of proteins removed from detergent-resistant domain preparations in reciprocal labeling experiments with the subsequent demonstration that these particular proteins are being enriched in the supernatant after pelleting of mβcd-treated membranes is the first evidence in plants that bioche...
[]
The combination of the analysis of proteins removed from detergent-resistant domain preparations in reciprocal labeling experiments with the subsequent demonstration that these particular proteins are being enriched in the supernatant after pelleting of mβcd-treated membranes is the first evidence in plants that bioche...
true
true
true
true
true
6,326
4
DISCUSSION
1
42
[ "r42" ]
19,036,721
pmid-17119156
This is an important conclusion drawn from our study, and it is well supported by work from the animal and yeast models where recent findings have strongly suggested that DRMs in standard biochemical preparations are not of the same composition as the in vivo functional lipid rafts in cells (42).
[ "42" ]
297
36,873
1
false
This is an important conclusion drawn from our study, and it is well supported by work from the animal and yeast models where recent findings have strongly suggested that DRMs in standard biochemical preparations are not of the same composition as the in vivo functional lipid rafts in cells.
[ "42" ]
This is an important conclusion drawn from our study, and it is well supported by work from the animal and yeast models where recent findings have strongly suggested that DRMs in standard biochemical preparations are not of the same composition as the in vivo functional lipid rafts in cells.
true
true
true
true
true
6,326
5
DISCUSSION
1
23
[ "r23", "r35", "r36", "r43", "r45", "r23", "r38" ]
19,036,721
pmid-12724530|pmid-14517339|pmid-16602701|pmid-14504402|pmid-15516372|pmid-12724530|pmid-9761744
In our study, cell wall-related proteins as well as lipid- and glucan-modifying proteins were the predominant classes of proteins identified as sterol-dependent in all experiments.
[ "23", "35", "36", "43", "45", "23", "38" ]
180
36,874
0
false
In our study, cell wall-related proteins as well as lipid- and glucan-modifying proteins were the predominant classes of proteins identified as sterol-dependent in all experiments.
[]
In our study, cell wall-related proteins as well as lipid- and glucan-modifying proteins were the predominant classes of proteins identified as sterol-dependent in all experiments.
true
true
true
true
true
6,327
5
DISCUSSION
1
23
[ "r23", "r35", "r36", "r43", "r45", "r23", "r38" ]
19,036,721
pmid-12724530|pmid-14517339|pmid-16602701|pmid-14504402|pmid-15516372|pmid-12724530|pmid-9761744
In contrast, proteomics studies on mammalian cell cultures using mβcd as a cholesterol-disrupting agent revealed a strong enrichment of signaling proteins, kinases, receptors, and transporters in lipid rafts (23).
[ "23", "35", "36", "43", "45", "23", "38" ]
213
36,875
1
false
In contrast, proteomics studies on mammalian cell cultures using mβcd as a cholesterol-disrupting agent revealed a strong enrichment of signaling proteins, kinases, receptors, and transporters in lipid rafts.
[ "23" ]
In contrast, proteomics studies on mammalian cell cultures using mβcd as a cholesterol-disrupting agent revealed a strong enrichment of signaling proteins, kinases, receptors, and transporters in lipid rafts.
true
true
true
true
true
6,327
5
DISCUSSION
1
23
[ "r23", "r35", "r36", "r43", "r45", "r23", "r38" ]
19,036,721
pmid-12724530|pmid-14517339|pmid-16602701|pmid-14504402|pmid-15516372|pmid-12724530|pmid-9761744
Although the functional groups of proteins removed by mβcd treatment differ between the animal and plant cells, they share common biochemistry: most proteins depleted after treatment of plant cells are experimentally proven to be GPI-anchored proteins (35, 36).
[ "23", "35", "36", "43", "45", "23", "38" ]
261
36,876
0
false
Although the functional groups of proteins removed by mβcd treatment differ between the animal and plant cells, they share common biochemistry: most proteins depleted after treatment of plant cells are experimentally proven to be GPI-anchored proteins.
[ "35, 36" ]
Although the functional groups of proteins removed by mβcd treatment differ between the animal and plant cells, they share common biochemistry: most proteins depleted after treatment of plant cells are experimentally proven to be GPI-anchored proteins.
true
true
true
true
true
6,327
5
DISCUSSION
1
23
[ "r23", "r35", "r36", "r43", "r45", "r23", "r38" ]
19,036,721
pmid-12724530|pmid-14517339|pmid-16602701|pmid-14504402|pmid-15516372|pmid-12724530|pmid-9761744
Of the 37 core proteins found as responding to mβcd in plant DRM (Table I), only eight are not modified with a glycosylphosphatidylinositol group, and one of them is predicted to be farnesylated.
[ "23", "35", "36", "43", "45", "23", "38" ]
195
36,877
0
false
Of the 37 core proteins found as responding to mβcd in plant DRM (Table I), only eight are not modified with a glycosylphosphatidylinositol group, and one of them is predicted to be farnesylated.
[]
Of the 37 core proteins found as responding to mβcd in plant DRM (Table I), only eight are not modified with a glycosylphosphatidylinositol group, and one of them is predicted to be farnesylated.
true
true
true
true
true
6,327
5
DISCUSSION
1
23
[ "r23", "r35", "r36", "r43", "r45", "r23", "r38" ]
19,036,721
pmid-12724530|pmid-14517339|pmid-16602701|pmid-14504402|pmid-15516372|pmid-12724530|pmid-9761744
Furthermore 22 of the GPI-anchored proteins were also found to be released to the supernatant after pelleting of mβcd-treated plasma membrane, and they showed the strongest amplitude of mβcd responses in all experiments.
[ "23", "35", "36", "43", "45", "23", "38" ]
220
36,878
0
false
Furthermore 22 of the GPI-anchored proteins were also found to be released to the supernatant after pelleting of mβcd-treated plasma membrane, and they showed the strongest amplitude of mβcd responses in all experiments.
[]
Furthermore 22 of the GPI-anchored proteins were also found to be released to the supernatant after pelleting of mβcd-treated plasma membrane, and they showed the strongest amplitude of mβcd responses in all experiments.
true
true
true
true
true
6,327
5
DISCUSSION
1
23
[ "r23", "r35", "r36", "r43", "r45", "r23", "r38" ]
19,036,721
pmid-12724530|pmid-14517339|pmid-16602701|pmid-14504402|pmid-15516372|pmid-12724530|pmid-9761744
These findings in plants are supported by earlier work on mammalian cells that the GPI anchor may be one of the (important) signals targeting a protein to lipid rafts and that the interaction of these proteins is specific to sterol-rich membrane domains (43–45).
[ "23", "35", "36", "43", "45", "23", "38" ]
262
36,879
0
false
These findings in plants are supported by earlier work on mammalian cells that the GPI anchor may be one of the (important) signals targeting a protein to lipid rafts and that the interaction of these proteins is specific to sterol-rich membrane domains.
[ "43–45" ]
These findings in plants are supported by earlier work on mammalian cells that the GPI anchor may be one of the (important) signals targeting a protein to lipid rafts and that the interaction of these proteins is specific to sterol-rich membrane domains.
true
true
true
true
true
6,327
5
DISCUSSION
1
23
[ "r23", "r35", "r36", "r43", "r45", "r23", "r38" ]
19,036,721
pmid-12724530|pmid-14517339|pmid-16602701|pmid-14504402|pmid-15516372|pmid-12724530|pmid-9761744
Furthermore in agreement with our findings, also quite a large percentage of proteins highly enriched as part of lipid rafts in HeLa cells (23) or human embryonic kidney cells (38) are actually GPI-anchored proteins.
[ "23", "35", "36", "43", "45", "23", "38" ]
216
36,880
1
false
Furthermore in agreement with our findings, also quite a large percentage of proteins highly enriched as part of lipid rafts in HeLa cells or human embryonic kidney cells are actually GPI-anchored proteins.
[ "23", "38" ]
Furthermore in agreement with our findings, also quite a large percentage of proteins highly enriched as part of lipid rafts in HeLa cells or human embryonic kidney cells are actually GPI-anchored proteins.
true
true
true
true
true
6,327
6
DISCUSSION
1
46
[ "r46", "r47", "r48" ]
19,036,721
pmid-15772281|pmid-14612561|pmid-14764879
The plant-specific structure of the cell wall requires anchoring and coordinated points of synthesis and modification.
[ "46", "47", "48" ]
118
36,881
0
false
The plant-specific structure of the cell wall requires anchoring and coordinated points of synthesis and modification.
[]
The plant-specific structure of the cell wall requires anchoring and coordinated points of synthesis and modification.
true
true
true
true
true
6,328
6
DISCUSSION
1
46
[ "r46", "r47", "r48" ]
19,036,721
pmid-15772281|pmid-14612561|pmid-14764879
In fact, it has clearly been shown in plants that correct membrane targeting of GPI-anchored proteins is essential for cell wall biosynthesis.
[ "46", "47", "48" ]
142
36,882
0
false
In fact, it has clearly been shown in plants that correct membrane targeting of GPI-anchored proteins is essential for cell wall biosynthesis.
[]
In fact, it has clearly been shown in plants that correct membrane targeting of GPI-anchored proteins is essential for cell wall biosynthesis.
true
true
true
true
true
6,328
6
DISCUSSION
1
46
[ "r46", "r47", "r48" ]
19,036,721
pmid-15772281|pmid-14612561|pmid-14764879
Mutants with deficient synthesis of GPI anchors display abnormal cell shapes (46).
[ "46", "47", "48" ]
82
36,883
1
false
Mutants with deficient synthesis of GPI anchors display abnormal cell shapes.
[ "46" ]
Mutants with deficient synthesis of GPI anchors display abnormal cell shapes.
true
true
true
true
true
6,328
6
DISCUSSION
1
46
[ "r46", "r47", "r48" ]
19,036,721
pmid-15772281|pmid-14612561|pmid-14764879
Interestingly in mammalian characterizations of lipid rafts using mβcd, many cytoskeletal proteins were found to be enriched in sterol-rich membrane domains.
[ "46", "47", "48" ]
157
36,884
0
false
Interestingly in mammalian characterizations of lipid rafts using mβcd, many cytoskeletal proteins were found to be enriched in sterol-rich membrane domains.
[]
Interestingly in mammalian characterizations of lipid rafts using mβcd, many cytoskeletal proteins were found to be enriched in sterol-rich membrane domains.
true
true
true
true
true
6,328
6
DISCUSSION
1
46
[ "r46", "r47", "r48" ]
19,036,721
pmid-15772281|pmid-14612561|pmid-14764879
Thus, possibly in plants the cell wall proteins, which make up the biggest functional group of proteins identified as responding to mβcd, anchor the “plant skeleton” (cell wall) to the plasma membrane in a similar way as mammalian cells anchor their cytoskeleton (47, 48).
[ "46", "47", "48" ]
272
36,885
0
false
Thus, possibly in plants the cell wall proteins, which make up the biggest functional group of proteins identified as responding to mβcd, anchor the “plant skeleton” (cell wall) to the plasma membrane in a similar way as mammalian cells anchor their cytoskeleton.
[ "47, 48" ]
Thus, possibly in plants the cell wall proteins, which make up the biggest functional group of proteins identified as responding to mβcd, anchor the “plant skeleton” (cell wall) to the plasma membrane in a similar way as mammalian cells anchor their cytoskeleton.
true
true
true
true
true
6,328
7
DISCUSSION
1
15
[ "r15", "r16" ]
19,036,721
pmid-15618420|pmid-15190066
Surprisingly a large proportion of proteins published as “lipid raft” proteins as concluded from their proteomics detection in DRM fractions (15, 16), such as many of the receptor-like kinases, did not show drastic depletion from DRM upon mβcd treatment.
[ "15", "16" ]
254
36,886
0
false
Surprisingly a large proportion of proteins published as “lipid raft” proteins as concluded from their proteomics detection in DRM fractions, such as many of the receptor-like kinases, did not show drastic depletion from DRM upon mβcd treatment.
[ "15, 16" ]
Surprisingly a large proportion of proteins published as “lipid raft” proteins as concluded from their proteomics detection in DRM fractions, such as many of the receptor-like kinases, did not show drastic depletion from DRM upon mβcd treatment.
true
true
true
true
true
6,329
7
DISCUSSION
1
15
[ "r15", "r16" ]
19,036,721
pmid-15618420|pmid-15190066
Moreover we observed an almost equal distribution of signaling proteins to sterol-dependent proteins and not sterol-dependent proteins (Fig.
[ "15", "16" ]
140
36,887
0
false
Moreover we observed an almost equal distribution of signaling proteins to sterol-dependent proteins and not sterol-dependent proteins (Fig.
[]
Moreover we observed an almost equal distribution of signaling proteins to sterol-dependent proteins and not sterol-dependent proteins (Fig.
true
true
true
true
true
6,329
7
DISCUSSION
1
15
[ "r15", "r16" ]
19,036,721
pmid-15618420|pmid-15190066
Thus, in our experiments a substantial number of these signaling proteins did not classify as sterol-dependent proteins in our study.
[ "15", "16" ]
133
36,888
0
false
Thus, in our experiments a substantial number of these signaling proteins did not classify as sterol-dependent proteins in our study.
[]
Thus, in our experiments a substantial number of these signaling proteins did not classify as sterol-dependent proteins in our study.
true
true
true
true
true
6,329
8
DISCUSSION
1
49
[ "r49" ]
19,036,721
pmid-15703292
We therefore conclude that sterol-rich membrane regions in plants consist of a “constant” core component mainly containing cell wall-related proteins and lipid-modifying activities and a dynamic component that includes the receptor-like kinases and other signaling proteins.
[ "49" ]
274
36,889
0
false
We therefore conclude that sterol-rich membrane regions in plants consist of a “constant” core component mainly containing cell wall-related proteins and lipid-modifying activities and a dynamic component that includes the receptor-like kinases and other signaling proteins.
[]
We therefore conclude that sterol-rich membrane regions in plants consist of a “constant” core component mainly containing cell wall-related proteins and lipid-modifying activities and a dynamic component that includes the receptor-like kinases and other signaling proteins.
true
true
true
true
true
6,330
8
DISCUSSION
1
49
[ "r49" ]
19,036,721
pmid-15703292
For example, a given receptor-like kinase may be found responsive to mβcd in one experimental set if under these particular conditions it is associated with sterol-rich membrane regions, whereas it may not be classified as mβcd-responsive in the experimental set carried out a few weeks later.
[ "49" ]
293
36,890
0
false
For example, a given receptor-like kinase may be found responsive to mβcd in one experimental set if under these particular conditions it is associated with sterol-rich membrane regions, whereas it may not be classified as mβcd-responsive in the experimental set carried out a few weeks later.
[]
For example, a given receptor-like kinase may be found responsive to mβcd in one experimental set if under these particular conditions it is associated with sterol-rich membrane regions, whereas it may not be classified as mβcd-responsive in the experimental set carried out a few weeks later.
true
true
true
true
true
6,330
8
DISCUSSION
1
49
[ "r49" ]
19,036,721
pmid-15703292
Dynamic polarized protein localization has been observed previously in response to pathogen infections (49).
[ "49" ]
108
36,891
1
false
Dynamic polarized protein localization has been observed previously in response to pathogen infections.
[ "49" ]
Dynamic polarized protein localization has been observed previously in response to pathogen infections.
true
true
true
true
true
6,330
8
DISCUSSION
1
49
[ "r49" ]
19,036,721
pmid-15703292
When cell cultures are treated with the elicitor peptide flg22, receptor kinase FLS2 displays a strong enrichment in DRM fractions, supporting the concept of stimulation-induced membrane microdomain localization of signaling proteins.2 Thus, diurnal effects of different harvesting times or subtle differences in cell cu...
[ "49" ]
464
36,892
0
false
When cell cultures are treated with the elicitor peptide flg22, receptor kinase FLS2 displays a strong enrichment in DRM fractions, supporting the concept of stimulation-induced membrane microdomain localization of signaling proteins.2 Thus, diurnal effects of different harvesting times or subtle differences in cell cu...
[]
When cell cultures are treated with the elicitor peptide flg22, receptor kinase FLS2 displays a strong enrichment in DRM fractions, supporting the concept of stimulation-induced membrane microdomain localization of signaling proteins.2 Thus, diurnal effects of different harvesting times or subtle differences in cell cu...
true
true
true
true
true
6,330
8
DISCUSSION
1
49
[ "r49" ]
19,036,721
pmid-15703292
The more variable mβcd-responsive proteins such as receptor kinases and transporters may be viewed as condition-dependent raft-associated proteins that may under particular circumstances (e.g.
[ "49" ]
192
36,893
0
false
The more variable mβcd-responsive proteins such as receptor kinases and transporters may be viewed as condition-dependent raft-associated proteins that may under particular circumstances (e.g.
[]
The more variable mβcd-responsive proteins such as receptor kinases and transporters may be viewed as condition-dependent raft-associated proteins that may under particular circumstances (e.g.
true
true
true
true
true
6,330
8
DISCUSSION
1
49
[ "r49" ]
19,036,721
pmid-15703292
stimulation of any kind) display mβcd-sensitive behavior.
[ "49" ]
57
36,894
0
false
stimulation of any kind) display mβcd-sensitive behavior.
[]
stimulation of any kind) display mβcd-sensitive behavior.
false
true
true
true
false
6,330
9
DISCUSSION
1
38
[ "r38", "r38" ]
19,036,721
pmid-9761744|pmid-9761744
In contrast, cell wall proteins, lipid-modifying proteins, and a set of proteins involved in vesicle transport seem to be a more constant component of plant sterol-rich membrane microdomains independent of external conditions.
[ "38", "38" ]
226
36,895
0
false
In contrast, cell wall proteins, lipid-modifying proteins, and a set of proteins involved in vesicle transport seem to be a more constant component of plant sterol-rich membrane microdomains independent of external conditions.
[]
In contrast, cell wall proteins, lipid-modifying proteins, and a set of proteins involved in vesicle transport seem to be a more constant component of plant sterol-rich membrane microdomains independent of external conditions.
true
true
true
true
true
6,331
9
DISCUSSION
1
38
[ "r38", "r38" ]
19,036,721
pmid-9761744|pmid-9761744
These findings are in agreement with the model of rafts consisting of a core of mβcd-sensitive proteins, most of which are GPI-anchored, and a peripheral zone with other proteins (38).
[ "38", "38" ]
184
36,896
1
false
These findings are in agreement with the model of rafts consisting of a core of mβcd-sensitive proteins, most of which are GPI-anchored, and a peripheral zone with other proteins.
[ "38" ]
These findings are in agreement with the model of rafts consisting of a core of mβcd-sensitive proteins, most of which are GPI-anchored, and a peripheral zone with other proteins.
true
true
true
true
true
6,331
9
DISCUSSION
1
38
[ "r38", "r38" ]
19,036,721
pmid-9761744|pmid-9761744
The majority of proteins we identified in detergent-resistant domains were not responsive to mβcd and thus in our view are not part of the raft model but part of membrane region that is still resistant to Triton X-100 treatment (38).
[ "38", "38" ]
233
36,897
1
false
The majority of proteins we identified in detergent-resistant domains were not responsive to mβcd and thus in our view are not part of the raft model but part of membrane region that is still resistant to Triton X-100 treatment.
[ "38" ]
The majority of proteins we identified in detergent-resistant domains were not responsive to mβcd and thus in our view are not part of the raft model but part of membrane region that is still resistant to Triton X-100 treatment.
true
true
true
true
true
6,331
10
DISCUSSION
0
null
null
19,036,721
null
In summary, our study is the first comprehensive analysis of plant sterol-rich microdomains making use of the sterol-disrupting drug mβcd, which has already been used in other organisms to characterize and develop models of lipid rafts.
null
236
36,898
0
false
null
null
In summary, our study is the first comprehensive analysis of plant sterol-rich microdomains making use of the sterol-disrupting drug mβcd, which has already been used in other organisms to characterize and develop models of lipid rafts.
true
true
true
true
true
6,332
10
DISCUSSION
0
null
null
19,036,721
null
We conclusively showed that DRM preparations in plants are not equal to sterol-rich microdomains known as lipid rafts.
null
118
36,899
0
false
null
null
We conclusively showed that DRM preparations in plants are not equal to sterol-rich microdomains known as lipid rafts.
true
true
true
true
true
6,332
10
DISCUSSION
0
null
null
19,036,721
null
Rather DRMs include sterol-rich membrane subdomains but also consist of a large fraction of sterol-independent proteins not affected by mβcd treatment.
null
151
36,900
0
false
null
null
Rather DRMs include sterol-rich membrane subdomains but also consist of a large fraction of sterol-independent proteins not affected by mβcd treatment.
true
true
true
true
true
6,332
10
DISCUSSION
0
null
null
19,036,721
null
In addition, this work provides the first evidence from plants that the sterol-rich membrane domains are dynamic structures consisting of a core set of structural cell wall-related proteins with GPI anchors and a condition-dependent variable protein component mainly with signaling functions.
null
292
36,901
0
false
null
null
In addition, this work provides the first evidence from plants that the sterol-rich membrane domains are dynamic structures consisting of a core set of structural cell wall-related proteins with GPI anchors and a condition-dependent variable protein component mainly with signaling functions.
true
true
true
true
true
6,332
0
INTRODUCTION
1
1
[ "DDP580C1", "DDP580C2", "DDP580C2", "DDP580C3", "DDP580C5", "DDP580C2", "DDP580C6", "DDP580C8", "DDP580C3", "DDP580C9", "DDP580C10" ]
20,047,948
NA|NA|NA|pmid-15464415|pmid-10796875|NA|pmid-6524300|pmid-12208131|pmid-15464415|pmid-3364161|pmid-6524300|pmid-3752966|pmid-1718128|pmid-6524300|pmid-3752966|pmid-7097276|pmid-10926300|pmid-15234332|pmid-6524300|pmid-2286024|pmid-14678774|pmid-15649698|pmid-15649698|pmid-12709427|pmid-16970941|pmid-15234332|pmid-19398...
Gaucher disease is caused by inherited deficiency of acid β-glucosidase (GCase).
[ "1", "2", "2", "3", "5", "2", "6", "8", "3", "9", "10" ]
80
36,902
0
false
Gaucher disease is caused by inherited deficiency of acid β-glucosidase (GCase).
[]
Gaucher disease is caused by inherited deficiency of acid β-glucosidase (GCase).
true
true
true
true
true
6,333
0
INTRODUCTION
1
1
[ "DDP580C1", "DDP580C2", "DDP580C2", "DDP580C3", "DDP580C5", "DDP580C2", "DDP580C6", "DDP580C8", "DDP580C3", "DDP580C9", "DDP580C10" ]
20,047,948
NA|NA|NA|pmid-15464415|pmid-10796875|NA|pmid-6524300|pmid-12208131|pmid-15464415|pmid-3364161|pmid-6524300|pmid-3752966|pmid-1718128|pmid-6524300|pmid-3752966|pmid-7097276|pmid-10926300|pmid-15234332|pmid-6524300|pmid-2286024|pmid-14678774|pmid-15649698|pmid-15649698|pmid-12709427|pmid-16970941|pmid-15234332|pmid-19398...
The mutations in the GCase gene [human (GBA), mouse (gba)] lead to defective hydrolysis of glucosylceramide (GC) that results in the storage of GC in the liver, spleen, bone marrow and central nervous system (1,2).
[ "1", "2", "2", "3", "5", "2", "6", "8", "3", "9", "10" ]
214
36,903
0
false
The mutations in the GCase gene [human (GBA), mouse (gba)] lead to defective hydrolysis of glucosylceramide (GC) that results in the storage of GC in the liver, spleen, bone marrow and central nervous system.
[ "1,2" ]
The mutations in the GCase gene [human (GBA), mouse (gba)] lead to defective hydrolysis of glucosylceramide (GC) that results in the storage of GC in the liver, spleen, bone marrow and central nervous system.
true
true
true
true
true
6,333
0
INTRODUCTION
1
1
[ "DDP580C1", "DDP580C2", "DDP580C2", "DDP580C3", "DDP580C5", "DDP580C2", "DDP580C6", "DDP580C8", "DDP580C3", "DDP580C9", "DDP580C10" ]
20,047,948
NA|NA|NA|pmid-15464415|pmid-10796875|NA|pmid-6524300|pmid-12208131|pmid-15464415|pmid-3364161|pmid-6524300|pmid-3752966|pmid-1718128|pmid-6524300|pmid-3752966|pmid-7097276|pmid-10926300|pmid-15234332|pmid-6524300|pmid-2286024|pmid-14678774|pmid-15649698|pmid-15649698|pmid-12709427|pmid-16970941|pmid-15234332|pmid-19398...
Clinically, two major categories of Gaucher disease have been delineated, non-neuronopathic and neuronopathic.
[ "1", "2", "2", "3", "5", "2", "6", "8", "3", "9", "10" ]
110
36,904
0
false
Clinically, two major categories of Gaucher disease have been delineated, non-neuronopathic and neuronopathic.
[]
Clinically, two major categories of Gaucher disease have been delineated, non-neuronopathic and neuronopathic.
true
true
true
true
true
6,333
0
INTRODUCTION
1
2
[ "DDP580C1", "DDP580C2", "DDP580C2", "DDP580C3", "DDP580C5", "DDP580C2", "DDP580C6", "DDP580C8", "DDP580C3", "DDP580C9", "DDP580C10" ]
20,047,948
NA|NA|NA|pmid-15464415|pmid-10796875|NA|pmid-6524300|pmid-12208131|pmid-15464415|pmid-3364161|pmid-6524300|pmid-3752966|pmid-1718128|pmid-6524300|pmid-3752966|pmid-7097276|pmid-10926300|pmid-15234332|pmid-6524300|pmid-2286024|pmid-14678774|pmid-15649698|pmid-15649698|pmid-12709427|pmid-16970941|pmid-15234332|pmid-19398...
Type 1 includes the non-neuropathic variants, whereas types 2 and 3 encompass the acute and subacute neuronopathic variants (2).
[ "1", "2", "2", "3", "5", "2", "6", "8", "3", "9", "10" ]
128
36,905
1
false
Type 1 includes the non-neuropathic variants, whereas types 2 and 3 encompass the acute and subacute neuronopathic variants.
[ "2" ]
Type 1 includes the non-neuropathic variants, whereas types 2 and 3 encompass the acute and subacute neuronopathic variants.
true
true
true
true
true
6,333
0
INTRODUCTION
1
1
[ "DDP580C1", "DDP580C2", "DDP580C2", "DDP580C3", "DDP580C5", "DDP580C2", "DDP580C6", "DDP580C8", "DDP580C3", "DDP580C9", "DDP580C10" ]
20,047,948
NA|NA|NA|pmid-15464415|pmid-10796875|NA|pmid-6524300|pmid-12208131|pmid-15464415|pmid-3364161|pmid-6524300|pmid-3752966|pmid-1718128|pmid-6524300|pmid-3752966|pmid-7097276|pmid-10926300|pmid-15234332|pmid-6524300|pmid-2286024|pmid-14678774|pmid-15649698|pmid-15649698|pmid-12709427|pmid-16970941|pmid-15234332|pmid-19398...
Type 2 is rare (<1/500 000 live births) and manifests progressive neuronopathic disease within the first 2–3 months with median survival of <1 year (3–5).
[ "1", "2", "2", "3", "5", "2", "6", "8", "3", "9", "10" ]
154
36,906
0
false
Type 2 is rare and manifests progressive neuronopathic disease within the first 2–3 months with median survival of <1 year.
[ "<1/500 000 live births", "3–5" ]
Type 2 is rare and manifests progressive neuronopathic disease within the first 2–3 months with median survival of <1 year.
true
true
true
true
true
6,333
0
INTRODUCTION
1
1
[ "DDP580C1", "DDP580C2", "DDP580C2", "DDP580C3", "DDP580C5", "DDP580C2", "DDP580C6", "DDP580C8", "DDP580C3", "DDP580C9", "DDP580C10" ]
20,047,948
NA|NA|NA|pmid-15464415|pmid-10796875|NA|pmid-6524300|pmid-12208131|pmid-15464415|pmid-3364161|pmid-6524300|pmid-3752966|pmid-1718128|pmid-6524300|pmid-3752966|pmid-7097276|pmid-10926300|pmid-15234332|pmid-6524300|pmid-2286024|pmid-14678774|pmid-15649698|pmid-15649698|pmid-12709427|pmid-16970941|pmid-15234332|pmid-19398...
Death results from severe progressive CNS and lung involvement.
[ "1", "2", "2", "3", "5", "2", "6", "8", "3", "9", "10" ]
63
36,907
0
false
Death results from severe progressive CNS and lung involvement.
[]
Death results from severe progressive CNS and lung involvement.
true
true
true
true
true
6,333
0
INTRODUCTION
1
2
[ "DDP580C1", "DDP580C2", "DDP580C2", "DDP580C3", "DDP580C5", "DDP580C2", "DDP580C6", "DDP580C8", "DDP580C3", "DDP580C9", "DDP580C10" ]
20,047,948
NA|NA|NA|pmid-15464415|pmid-10796875|NA|pmid-6524300|pmid-12208131|pmid-15464415|pmid-3364161|pmid-6524300|pmid-3752966|pmid-1718128|pmid-6524300|pmid-3752966|pmid-7097276|pmid-10926300|pmid-15234332|pmid-6524300|pmid-2286024|pmid-14678774|pmid-15649698|pmid-15649698|pmid-12709427|pmid-16970941|pmid-15234332|pmid-19398...
Type 3 is more slowly progressive, rare (1/100 000 live births) and has a wide spectrum of phenotypes extending from early severe visceral and mild neuropathic variants to mild visceral disease with uncontrollable seizures later in adolescence (2).
[ "1", "2", "2", "3", "5", "2", "6", "8", "3", "9", "10" ]
248
36,908
1
false
Type 3 is more slowly progressive, rare and has a wide spectrum of phenotypes extending from early severe visceral and mild neuropathic variants to mild visceral disease with uncontrollable seizures later in adolescence.
[ "1/100 000 live births", "2" ]
Type 3 is more slowly progressive, rare and has a wide spectrum of phenotypes extending from early severe visceral and mild neuropathic variants to mild visceral disease with uncontrollable seizures later in adolescence.
true
true
true
true
true
6,333
0
INTRODUCTION
1
1
[ "DDP580C1", "DDP580C2", "DDP580C2", "DDP580C3", "DDP580C5", "DDP580C2", "DDP580C6", "DDP580C8", "DDP580C3", "DDP580C9", "DDP580C10" ]
20,047,948
NA|NA|NA|pmid-15464415|pmid-10796875|NA|pmid-6524300|pmid-12208131|pmid-15464415|pmid-3364161|pmid-6524300|pmid-3752966|pmid-1718128|pmid-6524300|pmid-3752966|pmid-7097276|pmid-10926300|pmid-15234332|pmid-6524300|pmid-2286024|pmid-14678774|pmid-15649698|pmid-15649698|pmid-12709427|pmid-16970941|pmid-15234332|pmid-19398...
In the neuronopathic variants, GC and glucosylsphingosine (GS) accumulations have been documented in the brain (6–8).
[ "1", "2", "2", "3", "5", "2", "6", "8", "3", "9", "10" ]
117
36,909
0
false
In the neuronopathic variants, GC and glucosylsphingosine (GS) accumulations have been documented in the brain.
[ "6–8" ]
In the neuronopathic variants, GC and glucosylsphingosine (GS) accumulations have been documented in the brain.
true
true
true
true
true
6,333
0
INTRODUCTION
1
1
[ "DDP580C1", "DDP580C2", "DDP580C2", "DDP580C3", "DDP580C5", "DDP580C2", "DDP580C6", "DDP580C8", "DDP580C3", "DDP580C9", "DDP580C10" ]
20,047,948
NA|NA|NA|pmid-15464415|pmid-10796875|NA|pmid-6524300|pmid-12208131|pmid-15464415|pmid-3364161|pmid-6524300|pmid-3752966|pmid-1718128|pmid-6524300|pmid-3752966|pmid-7097276|pmid-10926300|pmid-15234332|pmid-6524300|pmid-2286024|pmid-14678774|pmid-15649698|pmid-15649698|pmid-12709427|pmid-16970941|pmid-15234332|pmid-19398...
Unlike the visceral disease, pathogenesis in the CNS is not related to large storage cell (macrophages) accumulations but, rather, to neuronal death/drop-out that is propagated by toxic effects of GS and/or GC (3,9,10).
[ "1", "2", "2", "3", "5", "2", "6", "8", "3", "9", "10" ]
219
36,910
0
false
Unlike the visceral disease, pathogenesis in the CNS is not related to large storage cell (macrophages) accumulations but, rather, to neuronal death/drop-out that is propagated by toxic effects of GS and/or GC.
[ "3,9,10" ]
Unlike the visceral disease, pathogenesis in the CNS is not related to large storage cell (macrophages) accumulations but, rather, to neuronal death/drop-out that is propagated by toxic effects of GS and/or GC.
true
true
true
true
true
6,333
1
INTRODUCTION
1
11
[ "DDP580C11", "DDP580C12", "DDP580C13", "DDP580C14", "DDP580C15", "DDP580C11", "DDP580C16" ]
20,047,948
pmid-9668348|pmid-8663398|pmid-12813057|pmid-16061944|pmid-17954913|pmid-9668348|pmid-11051765
Saposins (A, B, C and D) are small (80 amino acids) protein enhancers of specific glycosphingolipid (GSL) hydrolase activities (11).
[ "11", "12", "13", "14", "15", "11", "16" ]
132
36,911
1
false
Saposins (A, B, C and D) are small (80 amino acids) protein enhancers of specific glycosphingolipid (GSL) hydrolase activities.
[ "11" ]
Saposins (A, B, C and D) are small (80 amino acids) protein enhancers of specific glycosphingolipid (GSL) hydrolase activities.
true
true
true
true
true
6,334
1
INTRODUCTION
1
12
[ "DDP580C11", "DDP580C12", "DDP580C13", "DDP580C14", "DDP580C15", "DDP580C11", "DDP580C16" ]
20,047,948
pmid-9668348|pmid-8663398|pmid-12813057|pmid-16061944|pmid-17954913|pmid-9668348|pmid-11051765
They derive from a single precursor protein, prosaposin, by proteolysis in the late endosome and lysosome (12).
[ "11", "12", "13", "14", "15", "11", "16" ]
111
36,912
1
false
They derive from a single precursor protein, prosaposin, by proteolysis in the late endosome and lysosome.
[ "12" ]
They derive from a single precursor protein, prosaposin, by proteolysis in the late endosome and lysosome.
true
true
true
true
true
6,334
1
INTRODUCTION
1
13
[ "DDP580C11", "DDP580C12", "DDP580C13", "DDP580C14", "DDP580C15", "DDP580C11", "DDP580C16" ]
20,047,948
pmid-9668348|pmid-8663398|pmid-12813057|pmid-16061944|pmid-17954913|pmid-9668348|pmid-11051765
Among the four saposins, only saposin C has activation and anti-proteolytic protective effects toward GCase (13).
[ "11", "12", "13", "14", "15", "11", "16" ]
113
36,913
1
false
Among the four saposins, only saposin C has activation and anti-proteolytic protective effects toward GCase.
[ "13" ]
Among the four saposins, only saposin C has activation and anti-proteolytic protective effects toward GCase.
true
true
true
true
true
6,334
1
INTRODUCTION
1
14
[ "DDP580C11", "DDP580C12", "DDP580C13", "DDP580C14", "DDP580C15", "DDP580C11", "DDP580C16" ]
20,047,948
pmid-9668348|pmid-8663398|pmid-12813057|pmid-16061944|pmid-17954913|pmid-9668348|pmid-11051765
Deficiency of saposin C leads to a variant form of Gaucher disease with GC accumulation in macrophages and in the CNS (14).
[ "11", "12", "13", "14", "15", "11", "16" ]
123
36,914
1
false
Deficiency of saposin C leads to a variant form of Gaucher disease with GC accumulation in macrophages and in the CNS.
[ "14" ]
Deficiency of saposin C leads to a variant form of Gaucher disease with GC accumulation in macrophages and in the CNS.
true
true
true
true
true
6,334
1
INTRODUCTION
1
15
[ "DDP580C11", "DDP580C12", "DDP580C13", "DDP580C14", "DDP580C15", "DDP580C11", "DDP580C16" ]
20,047,948
pmid-9668348|pmid-8663398|pmid-12813057|pmid-16061944|pmid-17954913|pmid-9668348|pmid-11051765
Saposin C's mode of GCase activation is related to induced alterations of the membrane bilayer that facilitate enzyme and substrate interaction (15).
[ "11", "12", "13", "14", "15", "11", "16" ]
149
36,915
1
false
Saposin C's mode of GCase activation is related to induced alterations of the membrane bilayer that facilitate enzyme and substrate interaction.
[ "15" ]
Saposin C's mode of GCase activation is related to induced alterations of the membrane bilayer that facilitate enzyme and substrate interaction.
true
true
true
true
true
6,334