Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
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22
INTRODUCTION
1
7
[ "B7" ]
17,483,517
pmid-15466295
The underlying algorithm for the Gibbs Centroid Sampler and the Gibbs Recursive Sampler is a forward–backward algorithm (7).
[ "7" ]
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The underlying algorithm for the Gibbs Centroid Sampler and the Gibbs Recursive Sampler is a forward–backward algorithm.
[ "7" ]
The underlying algorithm for the Gibbs Centroid Sampler and the Gibbs Recursive Sampler is a forward–backward algorithm.
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1,452
22
INTRODUCTION
1
7
[ "B7" ]
17,483,517
pmid-15466295
The forward step is the most compute intensive part of the algorithm, with runtime increasing as the square of the length of the individual sequences; thus, the most important factor affecting runtime is the length of the individual sequences.
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The forward step is the most compute intensive part of the algorithm, with runtime increasing as the square of the length of the individual sequences; thus, the most important factor affecting runtime is the length of the individual sequences.
[]
The forward step is the most compute intensive part of the algorithm, with runtime increasing as the square of the length of the individual sequences; thus, the most important factor affecting runtime is the length of the individual sequences.
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1,452
22
INTRODUCTION
1
7
[ "B7" ]
17,483,517
pmid-15466295
Other parameters, such as the number of sequences, the number of motif models, the number of seeds and the number of iterations, affect the runtime linearly.
[ "7" ]
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Other parameters, such as the number of sequences, the number of motif models, the number of seeds and the number of iterations, affect the runtime linearly.
[]
Other parameters, such as the number of sequences, the number of motif models, the number of seeds and the number of iterations, affect the runtime linearly.
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1,452
22
INTRODUCTION
1
7
[ "B7" ]
17,483,517
pmid-15466295
Therefore, due to the increased number of iterations for burn-in and sampling, the runtime of the centroid sampler is somewhat greater than that of the Gibbs Recursive Sampler.
[ "7" ]
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Therefore, due to the increased number of iterations for burn-in and sampling, the runtime of the centroid sampler is somewhat greater than that of the Gibbs Recursive Sampler.
[]
Therefore, due to the increased number of iterations for burn-in and sampling, the runtime of the centroid sampler is somewhat greater than that of the Gibbs Recursive Sampler.
true
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1,452
22
INTRODUCTION
1
7
[ "B7" ]
17,483,517
pmid-15466295
Additional parameters, such as the use of palindromic or direct repeat models, while not directly affecting the runtime of the centroid sampler, greatly improve its ability to discover realistic TFBS by taking into account the biological characteristics of the system under study.
[ "7" ]
280
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false
Additional parameters, such as the use of palindromic or direct repeat models, while not directly affecting the runtime of the centroid sampler, greatly improve its ability to discover realistic TFBS by taking into account the biological characteristics of the system under study.
[]
Additional parameters, such as the use of palindromic or direct repeat models, while not directly affecting the runtime of the centroid sampler, greatly improve its ability to discover realistic TFBS by taking into account the biological characteristics of the system under study.
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true
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1,452
22
INTRODUCTION
1
7
[ "B7" ]
17,483,517
pmid-15466295
The program lists the total execution time for the program as the last line of the output.
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The program lists the total execution time for the program as the last line of the output.
[]
The program lists the total execution time for the program as the last line of the output.
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1,452
23
INTRODUCTION
1
5
[ "B5", "B6", "B8", "B18" ]
17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
The Gibbs Sampler Web site contains tutorials for prokaryotic phylogenetic footprinting (http://bayesweb.wadsworth.org/web_help.PF.html) and for analysis of prokaryotic co-expression data from microarray and promoter fusion experiments (http://bayesweb.wadsworth.org/web_help_text.CE.html).
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The Gibbs Sampler Web site contains tutorials for prokaryotic phylogenetic footprinting (http://bayesweb.wadsworth.org/web_help.PF.html) and for analysis of prokaryotic co-expression data from microarray and promoter fusion experiments (http://bayesweb.wadsworth.org/web_help_text.CE.html).
[]
The Gibbs Sampler Web site contains tutorials for prokaryotic phylogenetic footprinting (http://bayesweb.wadsworth.org/web_help.PF.html) and for analysis of prokaryotic co-expression data from microarray and promoter fusion experiments (http://bayesweb.wadsworth.org/web_help_text.CE.html).
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23
INTRODUCTION
1
5
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17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
Links to these pages are provided on the main Gibbs entry pages.
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Links to these pages are provided on the main Gibbs entry pages.
[]
Links to these pages are provided on the main Gibbs entry pages.
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1,453
23
INTRODUCTION
1
5
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17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
The tutorials provide guidance to users for all the sampling modes available (site, motif, recursive and centroid), and for both the Gibbs Sampler web server and the stand-alone version of Gibbs.
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The tutorials provide guidance to users for all the sampling modes available (site, motif, recursive and centroid), and for both the Gibbs Sampler web server and the stand-alone version of Gibbs.
[]
The tutorials provide guidance to users for all the sampling modes available (site, motif, recursive and centroid), and for both the Gibbs Sampler web server and the stand-alone version of Gibbs.
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1,453
23
INTRODUCTION
1
5
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17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
Specifically, the Gibbs Sampler offers a large array of options, some of which are used to model-specific aspects of biological sequences, while others are meant to control details of how the sampling is done.
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Specifically, the Gibbs Sampler offers a large array of options, some of which are used to model-specific aspects of biological sequences, while others are meant to control details of how the sampling is done.
[]
Specifically, the Gibbs Sampler offers a large array of options, some of which are used to model-specific aspects of biological sequences, while others are meant to control details of how the sampling is done.
true
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1,453
23
INTRODUCTION
1
5
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17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
The tutorials focus on the options that are useful in modeling the biology of transcription regulation.
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The tutorials focus on the options that are useful in modeling the biology of transcription regulation.
[]
The tutorials focus on the options that are useful in modeling the biology of transcription regulation.
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1,453
23
INTRODUCTION
1
5
[ "B5", "B6", "B8", "B18" ]
17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
The particular examples presented in the tutorials are drawn from the studies presented in (5,6,8,18).
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The particular examples presented in the tutorials are drawn from the studies presented in.
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The particular examples presented in the tutorials are drawn from the studies presented in.
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1,453
23
INTRODUCTION
1
5
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17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
Each tutorial gives the command line used to run the analysis, a description of each parameter and why its particular value was chosen, and a link that will automatically run the data on the Gibbs Web site with the Gibbs Centroid Sampler or with the Gibbs Recursive Sampler.
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Each tutorial gives the command line used to run the analysis, a description of each parameter and why its particular value was chosen, and a link that will automatically run the data on the Gibbs Web site with the Gibbs Centroid Sampler or with the Gibbs Recursive Sampler.
[]
Each tutorial gives the command line used to run the analysis, a description of each parameter and why its particular value was chosen, and a link that will automatically run the data on the Gibbs Web site with the Gibbs Centroid Sampler or with the Gibbs Recursive Sampler.
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1,453
23
INTRODUCTION
1
5
[ "B5", "B6", "B8", "B18" ]
17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
The data from the examples can also be downloaded to be run with the stand-alone version.
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The data from the examples can also be downloaded to be run with the stand-alone version.
[]
The data from the examples can also be downloaded to be run with the stand-alone version.
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1,453
23
INTRODUCTION
1
5
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17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
It is important to note that Gibbs sampling is a stochastic process, and thus results run from the links may differ slightly from the examples.
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It is important to note that Gibbs sampling is a stochastic process, and thus results run from the links may differ slightly from the examples.
[]
It is important to note that Gibbs sampling is a stochastic process, and thus results run from the links may differ slightly from the examples.
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1,453
23
INTRODUCTION
1
5
[ "B5", "B6", "B8", "B18" ]
17,483,517
pmid-11160901|pmid-12368244|pmid-12933881|pmid-11416222
In addition, although the examples in these interactive tutorials use prokaryotic sequence data, the principles described and the reasoning behind how to choose parameters are species-independent; all sampling modes, including the Gibbs Centroid Sampler, can be readily applied to the analysis of eukaryotic sequences.
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In addition, although the examples in these interactive tutorials use prokaryotic sequence data, the principles described and the reasoning behind how to choose parameters are species-independent; all sampling modes, including the Gibbs Centroid Sampler, can be readily applied to the analysis of eukaryotic sequences.
[]
In addition, although the examples in these interactive tutorials use prokaryotic sequence data, the principles described and the reasoning behind how to choose parameters are species-independent; all sampling modes, including the Gibbs Centroid Sampler, can be readily applied to the analysis of eukaryotic sequences.
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1,453
24
INTRODUCTION
1
2
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17,483,517
NA|pmid-11416222|NA|pmid-12824370
The tutorials, besides presenting detailed examples of the use of the Gibbs software, provide insights into the interpretation of, and biological reasoning behind, the computational experiments.
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The tutorials, besides presenting detailed examples of the use of the Gibbs software, provide insights into the interpretation of, and biological reasoning behind, the computational experiments.
[]
The tutorials, besides presenting detailed examples of the use of the Gibbs software, provide insights into the interpretation of, and biological reasoning behind, the computational experiments.
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INTRODUCTION
1
2
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17,483,517
NA|pmid-11416222|NA|pmid-12824370
The tutorial examples illustrate how solutions from MAP-based samplers sometimes include low probability sites in the solution.
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The tutorial examples illustrate how solutions from MAP-based samplers sometimes include low probability sites in the solution.
[]
The tutorial examples illustrate how solutions from MAP-based samplers sometimes include low probability sites in the solution.
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1,454
24
INTRODUCTION
1
2
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17,483,517
NA|pmid-11416222|NA|pmid-12824370
These sites increase the MAP slightly but may be false positive predictions.
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These sites increase the MAP slightly but may be false positive predictions.
[]
These sites increase the MAP slightly but may be false positive predictions.
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1,454
24
INTRODUCTION
1
2
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17,483,517
NA|pmid-11416222|NA|pmid-12824370
The centroid sampler avoids these low probability predictions and is thus less likely to make false positive predictions (2).
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The centroid sampler avoids these low probability predictions and is thus less likely to make false positive predictions.
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The centroid sampler avoids these low probability predictions and is thus less likely to make false positive predictions.
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1,454
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INTRODUCTION
1
18
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NA|pmid-11416222|NA|pmid-12824370
This is illustrated in the tutorial example, ‘Co-expression data from a microarray study of M. tuberculosis genes’, where the data comes from microarray results (18) that report a set of co-expressed genes, a subset of which are likely co-regulated by a common transcription factor.
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This is illustrated in the tutorial example, ‘Co-expression data from a microarray study of M. tuberculosis genes’, where the data comes from microarray results that report a set of co-expressed genes, a subset of which are likely co-regulated by a common transcription factor.
[ "18" ]
This is illustrated in the tutorial example, ‘Co-expression data from a microarray study of M. tuberculosis genes’, where the data comes from microarray results that report a set of co-expressed genes, a subset of which are likely co-regulated by a common transcription factor.
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INTRODUCTION
1
2
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17,483,517
NA|pmid-11416222|NA|pmid-12824370
When the Gibbs Recursive Sampler is used on the upstream sequences from these co-expressed genes, the results include several sites with low probability in the MAP solution, whereas the Gibbs Centroid Sampler avoids these low probability sites.
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When the Gibbs Recursive Sampler is used on the upstream sequences from these co-expressed genes, the results include several sites with low probability in the MAP solution, whereas the Gibbs Centroid Sampler avoids these low probability sites.
[]
When the Gibbs Recursive Sampler is used on the upstream sequences from these co-expressed genes, the results include several sites with low probability in the MAP solution, whereas the Gibbs Centroid Sampler avoids these low probability sites.
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1,454
24
INTRODUCTION
1
2
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17,483,517
NA|pmid-11416222|NA|pmid-12824370
The fully Bayesian sampling process that is performed by the Gibbs Centroid Sampler is more robust at eliminating these likely false-positive predictions (2) than the process employed in previous versions of the sampler, where, once a MAP solution was found, the sampler was allowed (as an option) to sample among high p...
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The fully Bayesian sampling process that is performed by the Gibbs Centroid Sampler is more robust at eliminating these likely false-positive predictions than the process employed in previous versions of the sampler, where, once a MAP solution was found, the sampler was allowed (as an option) to sample among high proba...
[ "2" ]
The fully Bayesian sampling process that is performed by the Gibbs Centroid Sampler is more robust at eliminating these likely false-positive predictions than the process employed in previous versions of the sampler, where, once a MAP solution was found, the sampler was allowed (as an option) to sample among high proba...
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1,454
24
INTRODUCTION
1
3
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17,483,517
NA|pmid-11416222|NA|pmid-12824370
the frequency solution) (3).
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the frequency solution).
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the frequency solution).
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1,454
24
INTRODUCTION
1
2
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17,483,517
NA|pmid-11416222|NA|pmid-12824370
Since we began using centroid estimates, we have discovered that the inclusion of steps that even partially increase focus on MAP (or near MAP) solutions have a detrimental impact on the correct identification of sites.
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Since we began using centroid estimates, we have discovered that the inclusion of steps that even partially increase focus on MAP (or near MAP) solutions have a detrimental impact on the correct identification of sites.
[]
Since we began using centroid estimates, we have discovered that the inclusion of steps that even partially increase focus on MAP (or near MAP) solutions have a detrimental impact on the correct identification of sites.
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INTRODUCTION
0
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17,483,517
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The Gibbs Centroid Sampler can be used for the analysis of amino-acid sequences.
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The Gibbs Centroid Sampler can be used for the analysis of amino-acid sequences.
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INTRODUCTION
0
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17,483,517
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The link from the main Gibbs Web site page leads to a page allowing the entry of amino-acid sequences.
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The link from the main Gibbs Web site page leads to a page allowing the entry of amino-acid sequences.
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INTRODUCTION
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The Web site also contains a link to an online user guide, which describes the various parameters and their input formats, has detailed descriptions of the output and lists possible error messages and their causes.
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The Web site also contains a link to an online user guide, which describes the various parameters and their input formats, has detailed descriptions of the output and lists possible error messages and their causes.
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INTRODUCTION
0
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The Gibbs Sampler Web site allows a maximum of 1000 sequences of no longer than 10,000 nucleotides in length.
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The Gibbs Sampler Web site allows a maximum of 1000 sequences of no longer than 10,000 nucleotides in length.
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INTRODUCTION
0
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Users with larger datasets are directed to use the stand-alone version of the Gibbs Sampler.
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Users with larger datasets are directed to use the stand-alone version of the Gibbs Sampler.
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INTRODUCTION
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The tumor suppressor protein p53 is a sequence-specific DNA-binding transcription factor that regulates the cell cycle checkpoint pathway in response to DNA damage (1).
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The tumor suppressor protein p53 is a sequence-specific DNA-binding transcription factor that regulates the cell cycle checkpoint pathway in response to DNA damage.
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The tumor suppressor protein p53 is a sequence-specific DNA-binding transcription factor that regulates the cell cycle checkpoint pathway in response to DNA damage.
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INTRODUCTION
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The p53 gene is the most frequent target for genetic alterations in cancer, with mutations occurring in ∼50% of all human tumors (2,3).
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The p53 gene is the most frequent target for genetic alterations in cancer, with mutations occurring in ∼50% of all human tumors.
[ "2,3" ]
The p53 gene is the most frequent target for genetic alterations in cancer, with mutations occurring in ∼50% of all human tumors.
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INTRODUCTION
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The tumor suppressor functions of p53 are directly linked to its ability to control the expression of gene products implicated in cell cycle arrest and apoptosis (4,5).
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The tumor suppressor functions of p53 are directly linked to its ability to control the expression of gene products implicated in cell cycle arrest and apoptosis.
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The tumor suppressor functions of p53 are directly linked to its ability to control the expression of gene products implicated in cell cycle arrest and apoptosis.
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INTRODUCTION
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p53 binds as a tetramer to specific response elements located in the transcriptional control regions of p53 target genes, which initiates the recruitment of other transcriptional co-regulators to assemble a transcriptional complex that initiates RNA synthesis (1,6).
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p53 binds as a tetramer to specific response elements located in the transcriptional control regions of p53 target genes, which initiates the recruitment of other transcriptional co-regulators to assemble a transcriptional complex that initiates RNA synthesis.
[ "1,6" ]
p53 binds as a tetramer to specific response elements located in the transcriptional control regions of p53 target genes, which initiates the recruitment of other transcriptional co-regulators to assemble a transcriptional complex that initiates RNA synthesis.
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INTRODUCTION
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A broad spectrum of p53 downstream target genes have been identified to be controlled by p53 in a positive or negative manner (7).
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A broad spectrum of p53 downstream target genes have been identified to be controlled by p53 in a positive or negative manner.
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A broad spectrum of p53 downstream target genes have been identified to be controlled by p53 in a positive or negative manner.
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INTRODUCTION
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[ "B1", "B2", "B3", "B4", "B5", "B1", "B6", "B7" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
The fact that a variety of pathways are mediated by these p53 target genes demonstrates the role of p53 as an integrator of diverse cellular signals.
[ "1", "2", "3", "4", "5", "1", "6", "7" ]
149
9,135
0
false
The fact that a variety of pathways are mediated by these p53 target genes demonstrates the role of p53 as an integrator of diverse cellular signals.
[]
The fact that a variety of pathways are mediated by these p53 target genes demonstrates the role of p53 as an integrator of diverse cellular signals.
true
true
true
true
true
1,456
1
INTRODUCTION
1
1
[ "B1", "B8", "B9" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
The p53 protein contains two N-terminal activation domains, a DNA-binding domain, and a C-terminal oligomerization domain (1).
[ "1", "8", "9" ]
126
9,136
1
false
The p53 protein contains two N-terminal activation domains, a DNA-binding domain, and a C-terminal oligomerization domain.
[ "1" ]
The p53 protein contains two N-terminal activation domains, a DNA-binding domain, and a C-terminal oligomerization domain.
true
true
true
true
true
1,457
1
INTRODUCTION
1
1
[ "B1", "B8", "B9" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
The critical step for p53-mediated transcriptional activation is facilitated by the ability of p53 to simultaneously bind to specific DNA sequences and recruit CBP/p300 and other transcriptional co-regulators to p53-responsive promoters.
[ "1", "8", "9" ]
237
9,137
0
false
The critical step for p53-mediated transcriptional activation is facilitated by the ability of p53 to simultaneously bind to specific DNA sequences and recruit CBP/p300 and other transcriptional co-regulators to p53-responsive promoters.
[]
The critical step for p53-mediated transcriptional activation is facilitated by the ability of p53 to simultaneously bind to specific DNA sequences and recruit CBP/p300 and other transcriptional co-regulators to p53-responsive promoters.
true
true
true
true
true
1,457
1
INTRODUCTION
1
1
[ "B1", "B8", "B9" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
CBP/p300 recruitment appears to concomitantly bring the general transcription machinery, including TFIIB and TBP, and RNA polymerase II to the target promoters (8,9).
[ "1", "8", "9" ]
166
9,138
0
false
CBP/p300 recruitment appears to concomitantly bring the general transcription machinery, including TFIIB and TBP, and RNA polymerase II to the target promoters.
[ "8,9" ]
CBP/p300 recruitment appears to concomitantly bring the general transcription machinery, including TFIIB and TBP, and RNA polymerase II to the target promoters.
true
true
true
true
true
1,457
1
INTRODUCTION
1
1
[ "B1", "B8", "B9" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
Although a wealth of information exists concerning p53, it is unclear about the actual mechanism by which this critical tumor suppressor protein directly interacts with its target genes and co-regulators to mediate its transcriptional activity.
[ "1", "8", "9" ]
244
9,139
0
false
Although a wealth of information exists concerning p53, it is unclear about the actual mechanism by which this critical tumor suppressor protein directly interacts with its target genes and co-regulators to mediate its transcriptional activity.
[]
Although a wealth of information exists concerning p53, it is unclear about the actual mechanism by which this critical tumor suppressor protein directly interacts with its target genes and co-regulators to mediate its transcriptional activity.
true
true
true
true
true
1,457
2
INTRODUCTION
1
10
[ "B10", "B11 B12 B13", "B14", "B15", "B16", "B17 B18 B19 B20 B21 B22 B23", "B24", "B25" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
The PIAS proteins (protein inhibitor of activated STAT) were first identified as transcriptional co-regulators of the JAK-STAT pathway (10).
[ "10", "11–13", "14", "15", "16", "17–23", "24", "25" ]
140
9,140
1
false
The PIAS proteins (protein inhibitor of activated STAT) were first identified as transcriptional co-regulators of the JAK-STAT pathway.
[ "10" ]
The PIAS proteins (protein inhibitor of activated STAT) were first identified as transcriptional co-regulators of the JAK-STAT pathway.
true
true
true
true
true
1,458
2
INTRODUCTION
1
11–13
[ "B10", "B11 B12 B13", "B14", "B15", "B16", "B17 B18 B19 B20 B21 B22 B23", "B24", "B25" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
PIAS1 and PIAS3 can inhibit the activity of STAT1 and STAT3, respectively (11–13).
[ "10", "11–13", "14", "15", "16", "17–23", "24", "25" ]
82
9,141
1
false
PIAS1 and PIAS3 can inhibit the activity of STAT1 and STAT3, respectively.
[ "11–13" ]
PIAS1 and PIAS3 can inhibit the activity of STAT1 and STAT3, respectively.
true
true
true
true
true
1,458
2
INTRODUCTION
1
10
[ "B10", "B11 B12 B13", "B14", "B15", "B16", "B17 B18 B19 B20 B21 B22 B23", "B24", "B25" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
Recent studies imply that the PIAS proteins may play a role in chromatin modulation through sumoylation (14,15).
[ "10", "11–13", "14", "15", "16", "17–23", "24", "25" ]
112
9,142
0
false
Recent studies imply that the PIAS proteins may play a role in chromatin modulation through sumoylation.
[ "14,15" ]
Recent studies imply that the PIAS proteins may play a role in chromatin modulation through sumoylation.
true
true
true
true
true
1,458
2
INTRODUCTION
1
16
[ "B10", "B11 B12 B13", "B14", "B15", "B16", "B17 B18 B19 B20 B21 B22 B23", "B24", "B25" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
Sequence analysis indicates that the SUMO E3 ligase RING domain shares significant homology with the Miz domain of PIAS proteins (16).
[ "10", "11–13", "14", "15", "16", "17–23", "24", "25" ]
134
9,143
1
false
Sequence analysis indicates that the SUMO E3 ligase RING domain shares significant homology with the Miz domain of PIAS proteins.
[ "16" ]
Sequence analysis indicates that the SUMO E3 ligase RING domain shares significant homology with the Miz domain of PIAS proteins.
true
true
true
true
true
1,458
2
INTRODUCTION
1
17–23
[ "B10", "B11 B12 B13", "B14", "B15", "B16", "B17 B18 B19 B20 B21 B22 B23", "B24", "B25" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
Several PIAS proteins, such as PIASxα, xβ, 1 and 3, have been shown to interact with SUMO-1 and Ubc9 to sumoylate a variety of transcriptional factors and other regulatory proteins (17–23).
[ "10", "11–13", "14", "15", "16", "17–23", "24", "25" ]
189
9,144
1
false
Several PIAS proteins, such as PIASxα, xβ, 1 and 3, have been shown to interact with SUMO-1 and Ubc9 to sumoylate a variety of transcriptional factors and other regulatory proteins.
[ "17–23" ]
Several PIAS proteins, such as PIASxα, xβ, 1 and 3, have been shown to interact with SUMO-1 and Ubc9 to sumoylate a variety of transcriptional factors and other regulatory proteins.
true
true
true
true
true
1,458
2
INTRODUCTION
1
10
[ "B10", "B11 B12 B13", "B14", "B15", "B16", "B17 B18 B19 B20 B21 B22 B23", "B24", "B25" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
Particularly, it has been shown that the transcriptional activity of p53 can be regulated by PIAS through sumoylation (24,25).
[ "10", "11–13", "14", "15", "16", "17–23", "24", "25" ]
126
9,145
0
false
Particularly, it has been shown that the transcriptional activity of p53 can be regulated by PIAS through sumoylation.
[ "24,25" ]
Particularly, it has been shown that the transcriptional activity of p53 can be regulated by PIAS through sumoylation.
true
true
true
true
true
1,458
3
INTRODUCTION
1
26
[ "B26", "B27", "B15", "B28" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
hZimp10 and hZimp7, also named zmiz1 and zmiz2, respectively, are novel PIAS-like proteins that share a ring finger domain, termed Miz (msx-interacting zinc finger), with other PIAS proteins (26,27).
[ "26", "27", "15", "28" ]
199
9,146
0
false
hZimp10 and hZimp7, also named zmiz1 and zmiz2, respectively, are novel PIAS-like proteins that share a ring finger domain, termed Miz (msx-interacting zinc finger), with other PIAS proteins.
[ "26,27" ]
hZimp10 and hZimp7, also named zmiz1 and zmiz2, respectively, are novel PIAS-like proteins that share a ring finger domain, termed Miz (msx-interacting zinc finger), with other PIAS proteins.
false
true
true
true
false
1,459
3
INTRODUCTION
1
15
[ "B26", "B27", "B15", "B28" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
This domain has been shown to be important for PIAS-target protein interactions and post-translational modifications (15).
[ "26", "27", "15", "28" ]
122
9,147
1
false
This domain has been shown to be important for PIAS-target protein interactions and post-translational modifications.
[ "15" ]
This domain has been shown to be important for PIAS-target protein interactions and post-translational modifications.
true
true
true
true
true
1,459
3
INTRODUCTION
1
28
[ "B26", "B27", "B15", "B28" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
A novel Drosophila gene, termed tonalli (tna), appears to be the ortholog of hZimp7 and 10 (28).
[ "26", "27", "15", "28" ]
96
9,148
1
false
A novel Drosophila gene, termed tonalli (tna), appears to be the ortholog of hZimp7 and 10.
[ "28" ]
A novel Drosophila gene, termed tonalli (tna), appears to be the ortholog of hZimp7 and 10.
true
true
true
true
true
1,459
3
INTRODUCTION
1
26
[ "B26", "B27", "B15", "B28" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
The protein encoded by tna genetically interacts with the SWI2/SNF2 and Mediator complexes, implying a potential role for the hZimp proteins in transcription.
[ "26", "27", "15", "28" ]
158
9,149
0
false
The protein encoded by tna genetically interacts with the SWI2/SNF2 and Mediator complexes, implying a potential role for the hZimp proteins in transcription.
[]
The protein encoded by tna genetically interacts with the SWI2/SNF2 and Mediator complexes, implying a potential role for the hZimp proteins in transcription.
true
true
true
true
true
1,459
3
INTRODUCTION
1
26
[ "B26", "B27", "B15", "B28" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
To further explore their roles in transcription, we performed a yeast two-hybrid screen to seek out potential interacting proteins of hZimp7 and 10.
[ "26", "27", "15", "28" ]
148
9,150
0
false
To further explore their roles in transcription, we performed a yeast two-hybrid screen to seek out potential interacting proteins of hZimp7 and 10.
[]
To further explore their roles in transcription, we performed a yeast two-hybrid screen to seek out potential interacting proteins of hZimp7 and 10.
true
true
true
true
true
1,459
3
INTRODUCTION
1
26
[ "B26", "B27", "B15", "B28" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
Intriguingly, p53 was identified in the screen.
[ "26", "27", "15", "28" ]
47
9,151
0
false
Intriguingly, p53 was identified in the screen.
[]
Intriguingly, p53 was identified in the screen.
true
true
true
true
true
1,459
3
INTRODUCTION
1
26
[ "B26", "B27", "B15", "B28" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
Using different in vitro and in vivo approaches, we demonstrated that hZimp10 physically interacts with the p53 protein, and through the interaction hZimp10 augments p53-mediated transcription.
[ "26", "27", "15", "28" ]
193
9,152
0
false
Using different in vitro and in vivo approaches, we demonstrated that hZimp10 physically interacts with the p53 protein, and through the interaction hZimp10 augments p53-mediated transcription.
[]
Using different in vitro and in vivo approaches, we demonstrated that hZimp10 physically interacts with the p53 protein, and through the interaction hZimp10 augments p53-mediated transcription.
true
true
true
true
true
1,459
3
INTRODUCTION
1
26
[ "B26", "B27", "B15", "B28" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
These data elucidate a link between hZimp10 and p53 and demonstrate that hZimp10 is a transcriptional co-regulator of p53.
[ "26", "27", "15", "28" ]
122
9,153
0
false
These data elucidate a link between hZimp10 and p53 and demonstrate that hZimp10 is a transcriptional co-regulator of p53.
[]
These data elucidate a link between hZimp10 and p53 and demonstrate that hZimp10 is a transcriptional co-regulator of p53.
true
true
true
true
true
1,459
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
The p53 tumor suppressor is a DNA sequence-specific transcriptional factor that is mutated in ∼50% of human tumors (3).
[ "3", "48", "49", "50", "51", "26" ]
119
9,154
1
false
The p53 tumor suppressor is a DNA sequence-specific transcriptional factor that is mutated in ∼50% of human tumors.
[ "3" ]
The p53 tumor suppressor is a DNA sequence-specific transcriptional factor that is mutated in ∼50% of human tumors.
true
true
true
true
true
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
In response to a variety of cellular signals, perhaps the most well studied is its DNA damage function.
[ "3", "48", "49", "50", "51", "26" ]
103
9,155
0
false
In response to a variety of cellular signals, perhaps the most well studied is its DNA damage function.
[]
In response to a variety of cellular signals, perhaps the most well studied is its DNA damage function.
true
true
true
true
true
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
p53 regulates the transcription of numerous genes involved in different cellular processes, including cell cycle arrest and cell death.
[ "3", "48", "49", "50", "51", "26" ]
135
9,156
0
false
p53 regulates the transcription of numerous genes involved in different cellular processes, including cell cycle arrest and cell death.
[]
p53 regulates the transcription of numerous genes involved in different cellular processes, including cell cycle arrest and cell death.
false
true
true
true
false
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
Like other transcriptional factors, the transcriptional activity of p53 is largely dependent on its ability to recognize and bind specific DNA sequences and to recruit other necessary transcriptional co-regulators.
[ "3", "48", "49", "50", "51", "26" ]
214
9,157
0
false
Like other transcriptional factors, the transcriptional activity of p53 is largely dependent on its ability to recognize and bind specific DNA sequences and to recruit other necessary transcriptional co-regulators.
[]
Like other transcriptional factors, the transcriptional activity of p53 is largely dependent on its ability to recognize and bind specific DNA sequences and to recruit other necessary transcriptional co-regulators.
true
true
true
true
true
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
In recent years, numerous transcription co-regulators have been shown to either directly or indirectly interact with p53 to modulate its transcriptional activity.
[ "3", "48", "49", "50", "51", "26" ]
162
9,158
0
false
In recent years, numerous transcription co-regulators have been shown to either directly or indirectly interact with p53 to modulate its transcriptional activity.
[]
In recent years, numerous transcription co-regulators have been shown to either directly or indirectly interact with p53 to modulate its transcriptional activity.
true
true
true
true
true
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
For instance, physical and functional interactions between p53, p300 and HAT proteins have been well documented (48,49).
[ "3", "48", "49", "50", "51", "26" ]
120
9,159
0
false
For instance, physical and functional interactions between p53, p300 and HAT proteins have been well documented.
[ "48,49" ]
For instance, physical and functional interactions between p53, p300 and HAT proteins have been well documented.
true
true
true
true
true
1,460
0
DISCUSSION
1
50
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
The involvement of PRMT1 and CARM1 methyltransferases has also been demonstrated in previous studies (50).
[ "3", "48", "49", "50", "51", "26" ]
106
9,160
1
false
The involvement of PRMT1 and CARM1 methyltransferases has also been demonstrated in previous studies.
[ "50" ]
The involvement of PRMT1 and CARM1 methyltransferases has also been demonstrated in previous studies.
true
true
true
true
true
1,460
0
DISCUSSION
1
51
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
Importantly, p53 has been shown to facilitate formation of a preinitiation complex via direct interactions with the components of the general transcription complex (51).
[ "3", "48", "49", "50", "51", "26" ]
169
9,161
1
false
Importantly, p53 has been shown to facilitate formation of a preinitiation complex via direct interactions with the components of the general transcription complex.
[ "51" ]
Importantly, p53 has been shown to facilitate formation of a preinitiation complex via direct interactions with the components of the general transcription complex.
true
true
true
true
true
1,460
0
DISCUSSION
1
26
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
The experiments reported here demonstrate a specific protein–protein interaction between p53 and hZimp10, a novel PIAS-like protein (26).
[ "3", "48", "49", "50", "51", "26" ]
137
9,162
1
false
The experiments reported here demonstrate a specific protein–protein interaction between p53 and hZimp10, a novel PIAS-like protein.
[ "26" ]
The experiments reported here demonstrate a specific protein–protein interaction between p53 and hZimp10, a novel PIAS-like protein.
true
true
true
true
true
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
The interaction was first identified by a modified yeast two-hybrid screen.
[ "3", "48", "49", "50", "51", "26" ]
75
9,163
0
false
The interaction was first identified by a modified yeast two-hybrid screen.
[]
The interaction was first identified by a modified yeast two-hybrid screen.
true
true
true
true
true
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
Using GST pull-down and immunoprecipitation assays, we then show that p53 binds to hZimp10 both in vitro and in intact cells.
[ "3", "48", "49", "50", "51", "26" ]
125
9,164
0
false
Using GST pull-down and immunoprecipitation assays, we then show that p53 binds to hZimp10 both in vitro and in intact cells.
[]
Using GST pull-down and immunoprecipitation assays, we then show that p53 binds to hZimp10 both in vitro and in intact cells.
true
true
true
true
true
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
Moreover, immunofluorescence assays demonstrated that p53 co-localizes with hZimp10 within cell nuclei.
[ "3", "48", "49", "50", "51", "26" ]
103
9,165
0
false
Moreover, immunofluorescence assays demonstrated that p53 co-localizes with hZimp10 within cell nuclei.
[]
Moreover, immunofluorescence assays demonstrated that p53 co-localizes with hZimp10 within cell nuclei.
true
true
true
true
true
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
Furthermore, analysis of the interaction by ChIP (chromatin immunoprecipitation assay) on the promoter of the p21 gene, a downstream target of p53, showed that hZimp10 is involved in the p53-mediated transcriptional complex.
[ "3", "48", "49", "50", "51", "26" ]
224
9,166
0
false
Furthermore, analysis of the interaction by ChIP (chromatin immunoprecipitation assay) on the promoter of the p21 gene, a downstream target of p53, showed that hZimp10 is involved in the p53-mediated transcriptional complex.
[]
Furthermore, analysis of the interaction by ChIP (chromatin immunoprecipitation assay) on the promoter of the p21 gene, a downstream target of p53, showed that hZimp10 is involved in the p53-mediated transcriptional complex.
true
true
true
true
true
1,460
0
DISCUSSION
1
3
[ "B3", "B48", "B49", "B50", "B51", "B26" ]
17,584,785
pmid-8654922|pmid-3025664|pmid-8123467|pmid-12775760|pmid-7568035|pmid-8654922|pmid-9039259|pmid-10783169|pmid-8123467|pmid-15156177|pmid-15153330|pmid-15186775|pmid-8754830|pmid-14609956
Taken together, these multiple lines of evidence clearly indicate that p53 and hZimp10 can specifically interact in a biologically relevant manner.
[ "3", "48", "49", "50", "51", "26" ]
147
9,167
0
false
Taken together, these multiple lines of evidence clearly indicate that p53 and hZimp10 can specifically interact in a biologically relevant manner.
[]
Taken together, these multiple lines of evidence clearly indicate that p53 and hZimp10 can specifically interact in a biologically relevant manner.
true
true
true
true
true
1,460
1
DISCUSSION
1
26
[ "B26", "B26", "B34" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
To search for the biological consequence of the interaction between p53 and hZimp10, we performed a series of experiments to assess the effect of hZimp10 on p53-mediated transcription.
[ "26", "26", "34" ]
184
9,168
0
false
To search for the biological consequence of the interaction between p53 and hZimp10, we performed a series of experiments to assess the effect of hZimp10 on p53-mediated transcription.
[]
To search for the biological consequence of the interaction between p53 and hZimp10, we performed a series of experiments to assess the effect of hZimp10 on p53-mediated transcription.
true
true
true
true
true
1,461
1
DISCUSSION
1
26
[ "B26", "B26", "B34" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
As shown in this article, hZimp10 acts as a transcriptional co-activator to augment p53-mediated transcription.
[ "26", "26", "34" ]
111
9,169
0
false
As shown in this article, hZimp10 acts as a transcriptional co-activator to augment p53-mediated transcription.
[]
As shown in this article, hZimp10 acts as a transcriptional co-activator to augment p53-mediated transcription.
true
true
true
true
true
1,461
1
DISCUSSION
1
26
[ "B26", "B26", "B34" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
We observed that expression of exogenous hZimp10 or knockdown of endogenous hZimp10 affects p53-mediated transcription on both the p21 and Mdm2 promoters.
[ "26", "26", "34" ]
154
9,170
0
false
We observed that expression of exogenous hZimp10 or knockdown of endogenous hZimp10 affects p53-mediated transcription on both the p21 and Mdm2 promoters.
[]
We observed that expression of exogenous hZimp10 or knockdown of endogenous hZimp10 affects p53-mediated transcription on both the p21 and Mdm2 promoters.
true
true
true
true
true
1,461
1
DISCUSSION
1
26
[ "B26", "B26", "B34" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
Introducing exogenous hZimp10 into MCF7 cells also augments endogenous p53-mediated transcription by increasing p21 transcript levels.
[ "26", "26", "34" ]
134
9,171
0
false
Introducing exogenous hZimp10 into MCF7 cells also augments endogenous p53-mediated transcription by increasing p21 transcript levels.
[]
Introducing exogenous hZimp10 into MCF7 cells also augments endogenous p53-mediated transcription by increasing p21 transcript levels.
true
true
true
true
true
1,461
1
DISCUSSION
1
26
[ "B26", "B26", "B34" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
Interestingly, hZimp10 consistently up-regulates p53-mediated transcriptional activity in all cell contexts examined to date.
[ "26", "26", "34" ]
125
9,172
0
false
Interestingly, hZimp10 consistently up-regulates p53-mediated transcriptional activity in all cell contexts examined to date.
[]
Interestingly, hZimp10 consistently up-regulates p53-mediated transcriptional activity in all cell contexts examined to date.
true
true
true
true
true
1,461
1
DISCUSSION
1
26
[ "B26", "B26", "B34" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
This result is consistent with the observation that hZimp10 harbors a strong intrinsic transactivation domain within its C-terminus (26).
[ "26", "26", "34" ]
137
9,173
1
false
This result is consistent with the observation that hZimp10 harbors a strong intrinsic transactivation domain within its C-terminus.
[ "26" ]
This result is consistent with the observation that hZimp10 harbors a strong intrinsic transactivation domain within its C-terminus.
true
true
true
true
true
1,461
1
DISCUSSION
1
26
[ "B26", "B26", "B34" ]
17,584,785
pmid-8654922|pmid-15171255|pmid-11782467|pmid-14609956|pmid-14609956|pmid-16777850
It appears that through this domain hZimp10 can act as a transcriptional co-activator to augment p53-mediated transcription, which is consistent with previous observations showing that hZimp10 functions as a transcriptional co-activator of the androgen receptor and Smad3 (26,34).
[ "26", "26", "34" ]
280
9,174
0
false
It appears that through this domain hZimp10 can act as a transcriptional co-activator to augment p53-mediated transcription, which is consistent with previous observations showing that hZimp10 functions as a transcriptional co-activator of the androgen receptor and Smad3.
[ "26,34" ]
It appears that through this domain hZimp10 can act as a transcriptional co-activator to augment p53-mediated transcription, which is consistent with previous observations showing that hZimp10 functions as a transcriptional co-activator of the androgen receptor and Smad3.
true
true
true
true
true
1,461
2
DISCUSSION
1
52
[ "B52", "B53", "B54", "B22", "B25", "B24", "B22" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
It has been shown that the transcriptional activity of p53 can be regulated by multiple post-translational modifications, including phosphorylation, ubiquitination and acetylation (52).
[ "52", "53", "54", "22", "25", "24", "22" ]
185
9,175
1
false
It has been shown that the transcriptional activity of p53 can be regulated by multiple post-translational modifications, including phosphorylation, ubiquitination and acetylation.
[ "52" ]
It has been shown that the transcriptional activity of p53 can be regulated by multiple post-translational modifications, including phosphorylation, ubiquitination and acetylation.
true
true
true
true
true
1,462
2
DISCUSSION
1
52
[ "B52", "B53", "B54", "B22", "B25", "B24", "B22" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
In addition, p53 can also be covalently modified by sumoylation, which is mainly regulated through SUMO-1 (Small Ubiquitin-related Modifier 1) (53,54).
[ "52", "53", "54", "22", "25", "24", "22" ]
151
9,176
0
false
In addition, p53 can also be covalently modified by sumoylation, which is mainly regulated through SUMO-1 (Small Ubiquitin-related Modifier 1).
[ "53,54" ]
In addition, p53 can also be covalently modified by sumoylation, which is mainly regulated through SUMO-1 (Small Ubiquitin-related Modifier 1).
true
true
true
true
true
1,462
2
DISCUSSION
1
52
[ "B52", "B53", "B54", "B22", "B25", "B24", "B22" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
Recent studies have shown that PIAS proteins can bind to, sumoylate, and influence the activity of p53 (22,25).
[ "52", "53", "54", "22", "25", "24", "22" ]
111
9,177
0
false
Recent studies have shown that PIAS proteins can bind to, sumoylate, and influence the activity of p53.
[ "22,25" ]
Recent studies have shown that PIAS proteins can bind to, sumoylate, and influence the activity of p53.
true
true
true
true
true
1,462
2
DISCUSSION
1
24
[ "B52", "B53", "B54", "B22", "B25", "B24", "B22" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
In particular, PIAS1 and PIASxβ act as E3 ligases to enhance sumoylation of p53 in vivo and in vitro (24).
[ "52", "53", "54", "22", "25", "24", "22" ]
106
9,178
1
false
In particular, PIAS1 and PIASxβ act as E3 ligases to enhance sumoylation of p53 in vivo and in vitro.
[ "24" ]
In particular, PIAS1 and PIASxβ act as E3 ligases to enhance sumoylation of p53 in vivo and in vitro.
true
true
true
true
true
1,462
2
DISCUSSION
1
22
[ "B52", "B53", "B54", "B22", "B25", "B24", "B22" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
Although it has been shown that PIAS proteins negatively regulate the transcriptional activity of p53 through sumoylation, recent data indicated that PIAS1 and PIAS3 may function as activators of p53-dependent gene expression (22).
[ "52", "53", "54", "22", "25", "24", "22" ]
231
9,179
1
false
Although it has been shown that PIAS proteins negatively regulate the transcriptional activity of p53 through sumoylation, recent data indicated that PIAS1 and PIAS3 may function as activators of p53-dependent gene expression.
[ "22" ]
Although it has been shown that PIAS proteins negatively regulate the transcriptional activity of p53 through sumoylation, recent data indicated that PIAS1 and PIAS3 may function as activators of p53-dependent gene expression.
true
true
true
true
true
1,462
2
DISCUSSION
1
52
[ "B52", "B53", "B54", "B22", "B25", "B24", "B22" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
Previously, we have shown that Zimp10 co-localizes with the AR and SUMO-1 at replication foci and enhances AR sumoylation.
[ "52", "53", "54", "22", "25", "24", "22" ]
122
9,180
0
false
Previously, we have shown that Zimp10 co-localizes with the AR and SUMO-1 at replication foci and enhances AR sumoylation.
[]
Previously, we have shown that Zimp10 co-localizes with the AR and SUMO-1 at replication foci and enhances AR sumoylation.
true
true
true
true
true
1,462
2
DISCUSSION
1
52
[ "B52", "B53", "B54", "B22", "B25", "B24", "B22" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
However, the mechanism for hZimp10-mediated enhancement of p53 activity appears to be through a sumoylation-independent pathway because over-expression of hZimp10 and SUMO-1 in HEK293 cells showed no effect on sumoylation of the p53 protein (Supplementary Data).
[ "52", "53", "54", "22", "25", "24", "22" ]
262
9,181
0
false
However, the mechanism for hZimp10-mediated enhancement of p53 activity appears to be through a sumoylation-independent pathway because over-expression of hZimp10 and SUMO-1 in HEK293 cells showed no effect on sumoylation of the p53 protein (Supplementary Data).
[]
However, the mechanism for hZimp10-mediated enhancement of p53 activity appears to be through a sumoylation-independent pathway because over-expression of hZimp10 and SUMO-1 in HEK293 cells showed no effect on sumoylation of the p53 protein (Supplementary Data).
true
true
true
true
true
1,462
2
DISCUSSION
1
52
[ "B52", "B53", "B54", "B22", "B25", "B24", "B22" ]
17,584,785
pmid-10851063|pmid-9388184|pmid-9724754|pmid-10628744|pmid-14701874|pmid-14685683|pmid-11595179|pmid-11731472|pmid-11117529|pmid-12077349|pmid-12060666|pmid-11893729|pmid-11788578|pmid-12177000|pmid-11583632|pmid-11867732|pmid-10618704|pmid-11124955|pmid-10562558|pmid-11788578|pmid-11867732|pmid-11583632|pmid-11788578
In addition, our results indicate that the hZimp10-mediated enhancement of p53 activity may be at least partially Miz domain-independent because the strongest interaction was observed with a hZimp10 region containing only a portion of the Miz sequence (Figure 2A).
[ "52", "53", "54", "22", "25", "24", "22" ]
264
9,182
0
false
In addition, our results indicate that the hZimp10-mediated enhancement of p53 activity may be at least partially Miz domain-independent because the strongest interaction was observed with a hZimp10 region containing only a portion of the Miz sequence (Figure 2A).
[]
In addition, our results indicate that the hZimp10-mediated enhancement of p53 activity may be at least partially Miz domain-independent because the strongest interaction was observed with a hZimp10 region containing only a portion of the Miz sequence.
true
true
true
true
true
1,462
3
DISCUSSION
1
26
[ "B26", "B27", "B34", "B44", "B26", "B28", "B26", "B27", "B26", "B34", "B25" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
Recently, we have demonstrated that both hZimp7 and hZimp10 enhance the transcriptional activity of several transcriptional factors (26,27,34,44).
[ "26", "27", "34", "44", "26", "28", "26", "27", "26", "34", "25" ]
146
9,183
0
false
Recently, we have demonstrated that both hZimp7 and hZimp10 enhance the transcriptional activity of several transcriptional factors.
[ "26,27,34,44" ]
Recently, we have demonstrated that both hZimp7 and hZimp10 enhance the transcriptional activity of several transcriptional factors.
true
true
true
true
true
1,463
3
DISCUSSION
1
26
[ "B26", "B27", "B34", "B44", "B26", "B28", "B26", "B27", "B26", "B34", "B25" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
However, the precise mechanism(s) for these Zimp proteins in transcriptional regulation still remains unclear.
[ "26", "27", "34", "44", "26", "28", "26", "27", "26", "34", "25" ]
110
9,184
0
false
However, the precise mechanism(s) for these Zimp proteins in transcriptional regulation still remains unclear.
[]
However, the precise mechanism(s) for these Zimp proteins in transcriptional regulation still remains unclear.
true
true
true
true
true
1,463
3
DISCUSSION
1
26
[ "B26", "B27", "B34", "B44", "B26", "B28", "B26", "B27", "B26", "B34", "B25" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
Our previous data showing that hZimp10 co-localizes with newly synthesized DNA at replication foci throughout S phase suggest that hZimp10 may play an important role in both chromatin assembly and maintenance of chromatin (26).
[ "26", "27", "34", "44", "26", "28", "26", "27", "26", "34", "25" ]
227
9,185
1
false
Our previous data showing that hZimp10 co-localizes with newly synthesized DNA at replication foci throughout S phase suggest that hZimp10 may play an important role in both chromatin assembly and maintenance of chromatin.
[ "26" ]
Our previous data showing that hZimp10 co-localizes with newly synthesized DNA at replication foci throughout S phase suggest that hZimp10 may play an important role in both chromatin assembly and maintenance of chromatin.
true
true
true
true
true
1,463
3
DISCUSSION
1
28
[ "B26", "B27", "B34", "B44", "B26", "B28", "B26", "B27", "B26", "B34", "B25" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
Intriguingly, a homolog of human Zimp proteins, termed tonalli (tna), has been identified in Drosophila and was shown to genetically interact with SWI2/SNF2 and the Mediator complexes in complementation studies (28).
[ "26", "27", "34", "44", "26", "28", "26", "27", "26", "34", "25" ]
216
9,186
1
false
Intriguingly, a homolog of human Zimp proteins, termed tonalli (tna), has been identified in Drosophila and was shown to genetically interact with SWI2/SNF2 and the Mediator complexes in complementation studies.
[ "28" ]
Intriguingly, a homolog of human Zimp proteins, termed tonalli (tna), has been identified in Drosophila and was shown to genetically interact with SWI2/SNF2 and the Mediator complexes in complementation studies.
true
true
true
true
true
1,463
3
DISCUSSION
1
26
[ "B26", "B27", "B34", "B44", "B26", "B28", "B26", "B27", "B26", "B34", "B25" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
In addition, we have shown previously that the C-terminal proline-rich domains of hZimp7 and 10 possess significant intrinsic transcriptional activity (26,27), and through these domains, the Zimp proteins can enhance transcription both in trans and in cis.
[ "26", "27", "34", "44", "26", "28", "26", "27", "26", "34", "25" ]
256
9,187
0
false
In addition, we have shown previously that the C-terminal proline-rich domains of hZimp7 and 10 possess significant intrinsic transcriptional activity, and through these domains, the Zimp proteins can enhance transcription both in trans and in cis.
[ "26,27" ]
In addition, we have shown previously that the C-terminal proline-rich domains of hZimp7 and 10 possess significant intrinsic transcriptional activity, and through these domains, the Zimp proteins can enhance transcription both in trans and in cis.
true
true
true
true
true
1,463
3
DISCUSSION
1
26
[ "B26", "B27", "B34", "B44", "B26", "B28", "B26", "B27", "B26", "B34", "B25" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
The finding that hZimp10 augments p53-mediated transcription is consistent with our previous studies showing that hZimp10 functions as a transcriptional co-activator of the androgen receptor and Smad3/Smad4 (26,34).
[ "26", "27", "34", "44", "26", "28", "26", "27", "26", "34", "25" ]
215
9,188
0
false
The finding that hZimp10 augments p53-mediated transcription is consistent with our previous studies showing that hZimp10 functions as a transcriptional co-activator of the androgen receptor and Smad3/Smad4.
[ "26,34" ]
The finding that hZimp10 augments p53-mediated transcription is consistent with our previous studies showing that hZimp10 functions as a transcriptional co-activator of the androgen receptor and Smad3/Smad4.
true
true
true
true
true
1,463
3
DISCUSSION
1
26
[ "B26", "B27", "B34", "B44", "B26", "B28", "B26", "B27", "B26", "B34", "B25" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
Interestingly, the C-terminal proline-rich region is not found in other PIAS or PIAS-like proteins, suggesting that the Miz domain family may consist of distinct groups of proteins that contain unique structures and play distinct roles in regulating transcription and other cellular processes.
[ "26", "27", "34", "44", "26", "28", "26", "27", "26", "34", "25" ]
293
9,189
0
false
Interestingly, the C-terminal proline-rich region is not found in other PIAS or PIAS-like proteins, suggesting that the Miz domain family may consist of distinct groups of proteins that contain unique structures and play distinct roles in regulating transcription and other cellular processes.
[]
Interestingly, the C-terminal proline-rich region is not found in other PIAS or PIAS-like proteins, suggesting that the Miz domain family may consist of distinct groups of proteins that contain unique structures and play distinct roles in regulating transcription and other cellular processes.
true
true
true
true
true
1,463
3
DISCUSSION
1
26
[ "B26", "B27", "B34", "B44", "B26", "B28", "B26", "B27", "B26", "B34", "B25" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
Therefore, it is conceivable that although hZimp10 and other PIAS proteins interact with p53 physically, they may regulate the function of p53 through different mechanisms.
[ "26", "27", "34", "44", "26", "28", "26", "27", "26", "34", "25" ]
172
9,190
0
false
Therefore, it is conceivable that although hZimp10 and other PIAS proteins interact with p53 physically, they may regulate the function of p53 through different mechanisms.
[]
Therefore, it is conceivable that although hZimp10 and other PIAS proteins interact with p53 physically, they may regulate the function of p53 through different mechanisms.
true
true
true
true
true
1,463
3
DISCUSSION
1
25
[ "B26", "B27", "B34", "B44", "B26", "B28", "B26", "B27", "B26", "B34", "B25" ]
17,584,785
pmid-14609956|pmid-16051670|pmid-14685683|pmid-12466201|pmid-14609956|pmid-16051670|pmid-16777850|pmid-16862223|pmid-14609956|pmid-12466201|pmid-14609956|pmid-16051670|pmid-14609956|pmid-16777850|pmid-11867732
Indeed, this is in agreement with our results suggesting that the Miz domain is generally dispensable for the hZimp10–p53 interaction while published reports suggest that the Miz domain is important for PIAS–p53 interactions (25).
[ "26", "27", "34", "44", "26", "28", "26", "27", "26", "34", "25" ]
230
9,191
1
false
Indeed, this is in agreement with our results suggesting that the Miz domain is generally dispensable for the hZimp10–p53 interaction while published reports suggest that the Miz domain is important for PIAS–p53 interactions.
[ "25" ]
Indeed, this is in agreement with our results suggesting that the Miz domain is generally dispensable for the hZimp10–p53 interaction while published reports suggest that the Miz domain is important for PIAS–p53 interactions.
true
true
true
true
true
1,463
4
DISCUSSION
1
27
[ "B27", "B26", "B27" ]
17,584,785
pmid-16051670|pmid-14609956|pmid-16051670
hZimp7 and hZimp10 share significant sequence similarity, particularly within their C-terminal regions (27).
[ "27", "26", "27" ]
108
9,192
1
false
hZimp7 and hZimp10 share significant sequence similarity, particularly within their C-terminal regions.
[ "27" ]
hZimp7 and hZimp10 share significant sequence similarity, particularly within their C-terminal regions.
false
true
true
true
false
1,464
4
DISCUSSION
1
27
[ "B27", "B26", "B27" ]
17,584,785
pmid-16051670|pmid-14609956|pmid-16051670
Both proteins contain an intrinsic transactivation domain and function as transcriptional co-activators (26,27).
[ "27", "26", "27" ]
112
9,193
0
false
Both proteins contain an intrinsic transactivation domain and function as transcriptional co-activators.
[ "26,27" ]
Both proteins contain an intrinsic transactivation domain and function as transcriptional co-activators.
true
true
true
true
true
1,464
4
DISCUSSION
1
27
[ "B27", "B26", "B27" ]
17,584,785
pmid-16051670|pmid-14609956|pmid-16051670
These two Zimp proteins show different tissue distribution profiles, which may suggest unique roles for these proteins in regulating different target genes.
[ "27", "26", "27" ]
156
9,194
0
false
These two Zimp proteins show different tissue distribution profiles, which may suggest unique roles for these proteins in regulating different target genes.
[]
These two Zimp proteins show different tissue distribution profiles, which may suggest unique roles for these proteins in regulating different target genes.
true
true
true
true
true
1,464
4
DISCUSSION
1
27
[ "B27", "B26", "B27" ]
17,584,785
pmid-16051670|pmid-14609956|pmid-16051670
Our recent data showing that disruption of the Zimp10 gene in mice results in embryonic lethality at approximately E10.5 suggest that hZimp7 and 10 are not functionally redundant.
[ "27", "26", "27" ]
179
9,195
0
false
Our recent data showing that disruption of the Zimp10 gene in mice results in embryonic lethality at approximately E10.5 suggest that hZimp7 and 10 are not functionally redundant.
[]
Our recent data showing that disruption of the Zimp10 gene in mice results in embryonic lethality at approximately E10.5 suggest that hZimp7 and 10 are not functionally redundant.
true
true
true
true
true
1,464
4
DISCUSSION
1
27
[ "B27", "B26", "B27" ]
17,584,785
pmid-16051670|pmid-14609956|pmid-16051670
In this study, even though we observed that hZimp7 interacts with p53 in a yeast two-hybrid assay, it showed no interaction between the two intact proteins in immunoprecipitation assays (see Supplementary Data).
[ "27", "26", "27" ]
211
9,196
0
false
In this study, even though we observed that hZimp7 interacts with p53 in a yeast two-hybrid assay, it showed no interaction between the two intact proteins in immunoprecipitation assays (see Supplementary Data).
[]
In this study, even though we observed that hZimp7 interacts with p53 in a yeast two-hybrid assay, it showed no interaction between the two intact proteins in immunoprecipitation assays (see Supplementary Data).
true
true
true
true
true
1,464
4
DISCUSSION
1
27
[ "B27", "B26", "B27" ]
17,584,785
pmid-16051670|pmid-14609956|pmid-16051670
In addition, we only observed a very weak effect of hZimp7 on p53-mediated transcription.
[ "27", "26", "27" ]
89
9,197
0
false
In addition, we only observed a very weak effect of hZimp7 on p53-mediated transcription.
[]
In addition, we only observed a very weak effect of hZimp7 on p53-mediated transcription.
true
true
true
true
true
1,464
4
DISCUSSION
1
27
[ "B27", "B26", "B27" ]
17,584,785
pmid-16051670|pmid-14609956|pmid-16051670
These data suggest that hZimp7 and hZimp10 proteins, although structurally similar, likely play a different role in p53-mediated transcription.
[ "27", "26", "27" ]
143
9,198
0
false
These data suggest that hZimp7 and hZimp10 proteins, although structurally similar, likely play a different role in p53-mediated transcription.
[]
These data suggest that hZimp7 and hZimp10 proteins, although structurally similar, likely play a different role in p53-mediated transcription.
true
true
true
true
true
1,464
5
DISCUSSION
0
null
null
17,584,785
null
In this study, we also assessed the interaction between hZimp10 and p53 in Zimp10 null cells.
null
93
9,199
0
false
null
null
In this study, we also assessed the interaction between hZimp10 and p53 in Zimp10 null cells.
true
true
true
true
true
1,465