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PMC2228368_fig01_17148.jpg | What's the most prominent thing you notice in this picture? | Analysis of OBs. Macro- and microscopic analysis of OB from m/m and +/+ mice. (A) Macroscopic view of a m/m mouse compared with a +/+ littermate at 9 weeks old. (B) +/+ OB showing normal size of OB. (C) m/m OB showing decreased size compared with +/+. (D) m/m show decreased volume of the OB compared with either +/+ or ... |
PMC2228368_fig01_17149.jpg | What is the focal point of this photograph? | Analysis of OBs. Macro- and microscopic analysis of OB from m/m and +/+ mice. (A) Macroscopic view of a m/m mouse compared with a +/+ littermate at 9 weeks old. (B) +/+ OB showing normal size of OB. (C) m/m OB showing decreased size compared with +/+. (D) m/m show decreased volume of the OB compared with either +/+ or ... |
PMC2228368_fig03_17146.jpg | What is the main focus of this visual representation? | Neuronal differentiation in olfactory bulb (OB) and RMS. (A) Tyrosine hydroxylase (TH) staining in the GL of the +/+ OB. (B) There is severe depletion of TH in the OB GL of m/m mice compared with either +/+ or +/– (**P < 0.01 versus +/+, +/m; n = 5). (C) DCX-positive neurons in the RMS of +/+. (C′) 20 × magnification. ... |
PMC2228368_fig03_17144.jpg | What is the dominant medical problem in this image? | Neuronal differentiation in olfactory bulb (OB) and RMS. (A) Tyrosine hydroxylase (TH) staining in the GL of the +/+ OB. (B) There is severe depletion of TH in the OB GL of m/m mice compared with either +/+ or +/– (**P < 0.01 versus +/+, +/m; n = 5). (C) DCX-positive neurons in the RMS of +/+. (C′) 20 × magnification. ... |
PMC2228368_fig03_17141.jpg | What object or scene is depicted here? | Neuronal differentiation in olfactory bulb (OB) and RMS. (A) Tyrosine hydroxylase (TH) staining in the GL of the +/+ OB. (B) There is severe depletion of TH in the OB GL of m/m mice compared with either +/+ or +/– (**P < 0.01 versus +/+, +/m; n = 5). (C) DCX-positive neurons in the RMS of +/+. (C′) 20 × magnification. ... |
PMC2228368_fig03_17142.jpg | What stands out most in this visual? | Neuronal differentiation in olfactory bulb (OB) and RMS. (A) Tyrosine hydroxylase (TH) staining in the GL of the +/+ OB. (B) There is severe depletion of TH in the OB GL of m/m mice compared with either +/+ or +/– (**P < 0.01 versus +/+, +/m; n = 5). (C) DCX-positive neurons in the RMS of +/+. (C′) 20 × magnification. ... |
PMC2228374_fig02_17155.jpg | What is the main focus of this visual representation? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17160.jpg | What is shown in this image? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17166.jpg | What object or scene is depicted here? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17154.jpg | What is the central feature of this picture? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17164.jpg | What is the principal component of this image? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17163.jpg | What does this image primarily show? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17158.jpg | What does this image primarily show? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17157.jpg | What is shown in this image? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17165.jpg | What is the focal point of this photograph? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17167.jpg | What does this image primarily show? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17156.jpg | What object or scene is depicted here? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17162.jpg | What does this image primarily show? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228374_fig02_17159.jpg | Can you identify the primary element in this image? | Transfection of CD21 into Ramos cells impedes anti-CD19 uptake. Upper panels: freshly isolated human B-cells do not internalize Alexa555-labeled anti-CD19 within 3 h (A, red channel in C), although it does redistribute into patches on the cell surface (arrows) that co-localize with Alexa488-labeled anti-CD21 added post... |
PMC2228391_fig03_17168.jpg | What is the central feature of this picture? | Average BOLD signal and anaesthetic (see online edition for colour figure). The images illustrate the typical activation patterns that were found under the three anaesthetics used in the experiment: medetomidine (top row), urethane (middle row) and isoflurane (bottom row). The signal shown here is for all sounds presen... |
PMC2228391_fig03_17169.jpg | What is the focal point of this photograph? | Average BOLD signal and anaesthetic (see online edition for colour figure). The images illustrate the typical activation patterns that were found under the three anaesthetics used in the experiment: medetomidine (top row), urethane (middle row) and isoflurane (bottom row). The signal shown here is for all sounds presen... |
PMC2228391_fig03_17172.jpg | Describe the main subject of this image. | Average BOLD signal and anaesthetic (see online edition for colour figure). The images illustrate the typical activation patterns that were found under the three anaesthetics used in the experiment: medetomidine (top row), urethane (middle row) and isoflurane (bottom row). The signal shown here is for all sounds presen... |
PMC2228391_fig03_17171.jpg | What stands out most in this visual? | Average BOLD signal and anaesthetic (see online edition for colour figure). The images illustrate the typical activation patterns that were found under the three anaesthetics used in the experiment: medetomidine (top row), urethane (middle row) and isoflurane (bottom row). The signal shown here is for all sounds presen... |
PMC2228391_fig03_17173.jpg | What is the central feature of this picture? | Average BOLD signal and anaesthetic (see online edition for colour figure). The images illustrate the typical activation patterns that were found under the three anaesthetics used in the experiment: medetomidine (top row), urethane (middle row) and isoflurane (bottom row). The signal shown here is for all sounds presen... |
PMC2228398_fig03_17174.jpg | What key item or scene is captured in this photo? | Confocal (a, c) and SEM (b, d) pictures of the biofilm growing on anodes of fuel cells inoculated with Shewanella oneidensis MR-1. Fuel cells were fed with FW medium supplemented with lactate and (a, b) amino acids; (c, d) yeast extract. Anodes for CLSM examination were directly stained with the BacLight Live/Dead kit ... |
PMC2228398_fig03_17175.jpg | What is the principal component of this image? | Confocal (a, c) and SEM (b, d) pictures of the biofilm growing on anodes of fuel cells inoculated with Shewanella oneidensis MR-1. Fuel cells were fed with FW medium supplemented with lactate and (a, b) amino acids; (c, d) yeast extract. Anodes for CLSM examination were directly stained with the BacLight Live/Dead kit ... |
PMC2228398_fig03_17176.jpg | What does this image primarily show? | Confocal (a, c) and SEM (b, d) pictures of the biofilm growing on anodes of fuel cells inoculated with Shewanella oneidensis MR-1. Fuel cells were fed with FW medium supplemented with lactate and (a, b) amino acids; (c, d) yeast extract. Anodes for CLSM examination were directly stained with the BacLight Live/Dead kit ... |
PMC2229631_fig01_17186.jpg | What can you see in this picture? | Epidermal PGP 9.5-positive nerve fibres in (a) non-involved (b) and involved AD skin. Tryptase-positive mast cells in proximity to the basal membrane (c) and 5-HT1AR expression in involved skin (d). Note the apical epidermal expression of 5-HT1AR, the dendritic melanocytes (arrow), as well as the mononuclear cells (arr... |
PMC2229631_fig01_17185.jpg | What is the dominant medical problem in this image? | Epidermal PGP 9.5-positive nerve fibres in (a) non-involved (b) and involved AD skin. Tryptase-positive mast cells in proximity to the basal membrane (c) and 5-HT1AR expression in involved skin (d). Note the apical epidermal expression of 5-HT1AR, the dendritic melanocytes (arrow), as well as the mononuclear cells (arr... |
PMC2229631_fig01_17183.jpg | What's the most prominent thing you notice in this picture? | Epidermal PGP 9.5-positive nerve fibres in (a) non-involved (b) and involved AD skin. Tryptase-positive mast cells in proximity to the basal membrane (c) and 5-HT1AR expression in involved skin (d). Note the apical epidermal expression of 5-HT1AR, the dendritic melanocytes (arrow), as well as the mononuclear cells (arr... |
PMC2229631_fig01_17184.jpg | What can you see in this picture? | Epidermal PGP 9.5-positive nerve fibres in (a) non-involved (b) and involved AD skin. Tryptase-positive mast cells in proximity to the basal membrane (c) and 5-HT1AR expression in involved skin (d). Note the apical epidermal expression of 5-HT1AR, the dendritic melanocytes (arrow), as well as the mononuclear cells (arr... |
PMC2229631_fig01_17182.jpg | What is being portrayed in this visual content? | Epidermal PGP 9.5-positive nerve fibres in (a) non-involved (b) and involved AD skin. Tryptase-positive mast cells in proximity to the basal membrane (c) and 5-HT1AR expression in involved skin (d). Note the apical epidermal expression of 5-HT1AR, the dendritic melanocytes (arrow), as well as the mononuclear cells (arr... |
PMC2229631_fig01_17187.jpg | What is shown in this image? | Epidermal PGP 9.5-positive nerve fibres in (a) non-involved (b) and involved AD skin. Tryptase-positive mast cells in proximity to the basal membrane (c) and 5-HT1AR expression in involved skin (d). Note the apical epidermal expression of 5-HT1AR, the dendritic melanocytes (arrow), as well as the mononuclear cells (arr... |
PMC2229631_fig03_17180.jpg | What is the main focus of this visual representation? | Double staining for 5-HT2AR (a) and CD3 (b), SERT (c), and CD3 (d) respectively in the papillary dermis of involved skin. a and c, Texas red; b and d, FITC. Magnification, ×200. |
PMC2229631_fig03_17181.jpg | What is shown in this image? | Double staining for 5-HT2AR (a) and CD3 (b), SERT (c), and CD3 (d) respectively in the papillary dermis of involved skin. a and c, Texas red; b and d, FITC. Magnification, ×200. |
PMC2229631_fig03_17178.jpg | Describe the main subject of this image. | Double staining for 5-HT2AR (a) and CD3 (b), SERT (c), and CD3 (d) respectively in the papillary dermis of involved skin. a and c, Texas red; b and d, FITC. Magnification, ×200. |
PMC2229631_fig03_17179.jpg | What is the focal point of this photograph? | Double staining for 5-HT2AR (a) and CD3 (b), SERT (c), and CD3 (d) respectively in the papillary dermis of involved skin. a and c, Texas red; b and d, FITC. Magnification, ×200. |
PMC2229647_pone-0001614-g001_17189.jpg | What object or scene is depicted here? | Histopathology of the small intestine.H&E-stained tissue sections of duodenum and proximal jejunum from rhesus macaques with idiopathic diarrhea. (A) Normal control duodenum from an age-matched rhesus macaque illustrating characteristic morphology of the villi. 100× magnification. (B) Enteropathy of duodenum. Diffuse e... |
PMC2229647_pone-0001614-g001_17190.jpg | What object or scene is depicted here? | Histopathology of the small intestine.H&E-stained tissue sections of duodenum and proximal jejunum from rhesus macaques with idiopathic diarrhea. (A) Normal control duodenum from an age-matched rhesus macaque illustrating characteristic morphology of the villi. 100× magnification. (B) Enteropathy of duodenum. Diffuse e... |
PMC2229647_pone-0001614-g001_17191.jpg | What stands out most in this visual? | Histopathology of the small intestine.H&E-stained tissue sections of duodenum and proximal jejunum from rhesus macaques with idiopathic diarrhea. (A) Normal control duodenum from an age-matched rhesus macaque illustrating characteristic morphology of the villi. 100× magnification. (B) Enteropathy of duodenum. Diffuse e... |
PMC2229663_pone-0001608-g003_17192.jpg | What is being portrayed in this visual content? |
P. berghei-GFP infection impairs pregnancy outcome and fetus development.(A) Representative uterus at G18 from BALB/c pregnant females, uninfected (upper) and infected on G13 with P. berghei-GFP by IV injection of 106 iRBC (bottom). The arrowheads indicate abortions. (B) Fetus from uninfected (left) and from infected... |
PMC2229663_pone-0001608-g003_17193.jpg | What is shown in this image? |
P. berghei-GFP infection impairs pregnancy outcome and fetus development.(A) Representative uterus at G18 from BALB/c pregnant females, uninfected (upper) and infected on G13 with P. berghei-GFP by IV injection of 106 iRBC (bottom). The arrowheads indicate abortions. (B) Fetus from uninfected (left) and from infected... |
PMC2229663_pone-0001608-g003_17195.jpg | What stands out most in this visual? |
P. berghei-GFP infection impairs pregnancy outcome and fetus development.(A) Representative uterus at G18 from BALB/c pregnant females, uninfected (upper) and infected on G13 with P. berghei-GFP by IV injection of 106 iRBC (bottom). The arrowheads indicate abortions. (B) Fetus from uninfected (left) and from infected... |
PMC2229663_pone-0001608-g003_17194.jpg | What is the focal point of this photograph? |
P. berghei-GFP infection impairs pregnancy outcome and fetus development.(A) Representative uterus at G18 from BALB/c pregnant females, uninfected (upper) and infected on G13 with P. berghei-GFP by IV injection of 106 iRBC (bottom). The arrowheads indicate abortions. (B) Fetus from uninfected (left) and from infected... |
PMC2229663_pone-0001608-g005_17196.jpg | What is the focal point of this photograph? | Placental malaria.HE stained placentas from BALB/c females infected with P. berghei-GFP and collected at G18. (A) Image from severely infected placenta with high number of parasitized maternal erythrocytes. (B) The same field as (A) under polarization microscopy revealing hemozoin parasite pigment. (C) Arrowhead and in... |
PMC2229663_pone-0001608-g005_17199.jpg | What key item or scene is captured in this photo? | Placental malaria.HE stained placentas from BALB/c females infected with P. berghei-GFP and collected at G18. (A) Image from severely infected placenta with high number of parasitized maternal erythrocytes. (B) The same field as (A) under polarization microscopy revealing hemozoin parasite pigment. (C) Arrowhead and in... |
PMC2229664_pone-0001609-g001_17212.jpg | What is the core subject represented in this visual? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17214.jpg | What is being portrayed in this visual content? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17208.jpg | What is the dominant medical problem in this image? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17206.jpg | What's the most prominent thing you notice in this picture? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17219.jpg | What is the main focus of this visual representation? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17204.jpg | What is the principal component of this image? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17216.jpg | What is the dominant medical problem in this image? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17202.jpg | What is the central feature of this picture? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17203.jpg | What is the dominant medical problem in this image? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17210.jpg | Can you identify the primary element in this image? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17209.jpg | Can you identify the primary element in this image? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17200.jpg | What is shown in this image? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229664_pone-0001609-g001_17211.jpg | What is the dominant medical problem in this image? | Alteration of RNF5 pattern is evident in muscle biopsies from both patients with sIBM and in a hIBM mouse model.A. Immunohistological analysis of RNF5 protein in a normal muscle biopsy and in biopsies from 2 representative sIBM patients. RNF5 staining was also positive in aggregates from 10 independent sIBM patients (n... |
PMC2229837_fig01_17223.jpg | What is shown in this image? | Qualitative screen for mutants with fewer dead cells. Cultures of the mutants, WT and controls were spotted onto agar plates containing PI, and screened visually in the microscope. Images are 40× magnification grey-scale pictures taken with simultaneous phase contrast and fluorescent light. Bright cells represent dead ... |
PMC2229837_fig01_17222.jpg | What's the most prominent thing you notice in this picture? | Qualitative screen for mutants with fewer dead cells. Cultures of the mutants, WT and controls were spotted onto agar plates containing PI, and screened visually in the microscope. Images are 40× magnification grey-scale pictures taken with simultaneous phase contrast and fluorescent light. Bright cells represent dead ... |
PMC2229837_fig01_17224.jpg | Describe the main subject of this image. | Qualitative screen for mutants with fewer dead cells. Cultures of the mutants, WT and controls were spotted onto agar plates containing PI, and screened visually in the microscope. Images are 40× magnification grey-scale pictures taken with simultaneous phase contrast and fluorescent light. Bright cells represent dead ... |
PMC2229861_pbio-0050317-g001_17249.jpg | What object or scene is depicted here? | Depletion of mDia2 in B16F1 Cells by siRNA(A) Staining of endogenous mDia2 by antibody (red) and actin by phalloidin (green). mDia2 is concentrated in lamellipodia and at filopodial tips (see insets at right).(B) Western blotting of cell populations transfected with control or mDia2 siRNA. Tubulin is used as a loading ... |
PMC2229861_pbio-0050317-g001_17254.jpg | What is the principal component of this image? | Depletion of mDia2 in B16F1 Cells by siRNA(A) Staining of endogenous mDia2 by antibody (red) and actin by phalloidin (green). mDia2 is concentrated in lamellipodia and at filopodial tips (see insets at right).(B) Western blotting of cell populations transfected with control or mDia2 siRNA. Tubulin is used as a loading ... |
PMC2229861_pbio-0050317-g001_17250.jpg | What can you see in this picture? | Depletion of mDia2 in B16F1 Cells by siRNA(A) Staining of endogenous mDia2 by antibody (red) and actin by phalloidin (green). mDia2 is concentrated in lamellipodia and at filopodial tips (see insets at right).(B) Western blotting of cell populations transfected with control or mDia2 siRNA. Tubulin is used as a loading ... |
PMC2229861_pbio-0050317-g001_17256.jpg | Describe the main subject of this image. | Depletion of mDia2 in B16F1 Cells by siRNA(A) Staining of endogenous mDia2 by antibody (red) and actin by phalloidin (green). mDia2 is concentrated in lamellipodia and at filopodial tips (see insets at right).(B) Western blotting of cell populations transfected with control or mDia2 siRNA. Tubulin is used as a loading ... |
PMC2229861_pbio-0050317-g001_17255.jpg | What is the principal component of this image? | Depletion of mDia2 in B16F1 Cells by siRNA(A) Staining of endogenous mDia2 by antibody (red) and actin by phalloidin (green). mDia2 is concentrated in lamellipodia and at filopodial tips (see insets at right).(B) Western blotting of cell populations transfected with control or mDia2 siRNA. Tubulin is used as a loading ... |
PMC2229861_pbio-0050317-g001_17259.jpg | What is the dominant medical problem in this image? | Depletion of mDia2 in B16F1 Cells by siRNA(A) Staining of endogenous mDia2 by antibody (red) and actin by phalloidin (green). mDia2 is concentrated in lamellipodia and at filopodial tips (see insets at right).(B) Western blotting of cell populations transfected with control or mDia2 siRNA. Tubulin is used as a loading ... |
PMC2229861_pbio-0050317-g001_17258.jpg | What stands out most in this visual? | Depletion of mDia2 in B16F1 Cells by siRNA(A) Staining of endogenous mDia2 by antibody (red) and actin by phalloidin (green). mDia2 is concentrated in lamellipodia and at filopodial tips (see insets at right).(B) Western blotting of cell populations transfected with control or mDia2 siRNA. Tubulin is used as a loading ... |
PMC2229861_pbio-0050317-g001_17257.jpg | What is the principal component of this image? | Depletion of mDia2 in B16F1 Cells by siRNA(A) Staining of endogenous mDia2 by antibody (red) and actin by phalloidin (green). mDia2 is concentrated in lamellipodia and at filopodial tips (see insets at right).(B) Western blotting of cell populations transfected with control or mDia2 siRNA. Tubulin is used as a loading ... |
PMC2229861_pbio-0050317-g004_17229.jpg | What is the principal component of this image? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17228.jpg | What key item or scene is captured in this photo? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17237.jpg | What is the dominant medical problem in this image? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17241.jpg | What does this image primarily show? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17240.jpg | What is the main focus of this visual representation? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17238.jpg | What is the core subject represented in this visual? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17227.jpg | What can you see in this picture? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17233.jpg | What stands out most in this visual? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17236.jpg | What is the focal point of this photograph? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17230.jpg | What is the dominant medical problem in this image? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g004_17226.jpg | What is the focal point of this photograph? | Lamellipodia of ΔGBD-mDia2–Expressing B16F1 Cells(A) Distribution of GFP-ΔGBD-mDia2 (red) and indicated cytoskeletal proteins (green) detected by phalloidin (Actin) or immunostaining (all others). ΔGBD-mDia2–positive lamellipodia contain normal lamellipodial components: actin, Arp2/3 complex, capping protein, VASP, Abi... |
PMC2229861_pbio-0050317-g005_17248.jpg | What key item or scene is captured in this photo? | Structural Organization of Lamellipodia in ΔGBD-mDia2–Expressing CellsCorrelative EM is used to unambiguously identify ΔGBD-mDia–positive regions.(A) Phase contrast image overlaid with the GFP-ΔGBD-mDia2 image in red.(B) Low-magnification EM image of the periphery of the same cell overlaid with GFP image in red. Boxes ... |
PMC2229861_pbio-0050317-g005_17246.jpg | What is the focal point of this photograph? | Structural Organization of Lamellipodia in ΔGBD-mDia2–Expressing CellsCorrelative EM is used to unambiguously identify ΔGBD-mDia–positive regions.(A) Phase contrast image overlaid with the GFP-ΔGBD-mDia2 image in red.(B) Low-magnification EM image of the periphery of the same cell overlaid with GFP image in red. Boxes ... |
PMC2229861_pbio-0050317-g005_17242.jpg | What is shown in this image? | Structural Organization of Lamellipodia in ΔGBD-mDia2–Expressing CellsCorrelative EM is used to unambiguously identify ΔGBD-mDia–positive regions.(A) Phase contrast image overlaid with the GFP-ΔGBD-mDia2 image in red.(B) Low-magnification EM image of the periphery of the same cell overlaid with GFP image in red. Boxes ... |
PMC2229861_pbio-0050317-g006_17271.jpg | What stands out most in this visual? | Filopodia Induction by ΔGBD-mDia2(A) Cytoskeletal proteins in ΔGBD-induced filopodia. GFP-, YFP-, or mRFP1-ΔGBD-mDia2 (red)-induced filopodia contain filopodial markers, actin, fascin, VASP, and myosin X, but Abi1 is not enriched there. Fascin, which normally localizes throughout the filopodia, is present only in thick... |
PMC2229861_pbio-0050317-g006_17273.jpg | What stands out most in this visual? | Filopodia Induction by ΔGBD-mDia2(A) Cytoskeletal proteins in ΔGBD-induced filopodia. GFP-, YFP-, or mRFP1-ΔGBD-mDia2 (red)-induced filopodia contain filopodial markers, actin, fascin, VASP, and myosin X, but Abi1 is not enriched there. Fascin, which normally localizes throughout the filopodia, is present only in thick... |
PMC2229861_pbio-0050317-g006_17282.jpg | What is the dominant medical problem in this image? | Filopodia Induction by ΔGBD-mDia2(A) Cytoskeletal proteins in ΔGBD-induced filopodia. GFP-, YFP-, or mRFP1-ΔGBD-mDia2 (red)-induced filopodia contain filopodial markers, actin, fascin, VASP, and myosin X, but Abi1 is not enriched there. Fascin, which normally localizes throughout the filopodia, is present only in thick... |
PMC2229861_pbio-0050317-g006_17277.jpg | What does this image primarily show? | Filopodia Induction by ΔGBD-mDia2(A) Cytoskeletal proteins in ΔGBD-induced filopodia. GFP-, YFP-, or mRFP1-ΔGBD-mDia2 (red)-induced filopodia contain filopodial markers, actin, fascin, VASP, and myosin X, but Abi1 is not enriched there. Fascin, which normally localizes throughout the filopodia, is present only in thick... |
PMC2229861_pbio-0050317-g006_17274.jpg | What is the focal point of this photograph? | Filopodia Induction by ΔGBD-mDia2(A) Cytoskeletal proteins in ΔGBD-induced filopodia. GFP-, YFP-, or mRFP1-ΔGBD-mDia2 (red)-induced filopodia contain filopodial markers, actin, fascin, VASP, and myosin X, but Abi1 is not enriched there. Fascin, which normally localizes throughout the filopodia, is present only in thick... |
PMC2229861_pbio-0050317-g006_17279.jpg | What's the most prominent thing you notice in this picture? | Filopodia Induction by ΔGBD-mDia2(A) Cytoskeletal proteins in ΔGBD-induced filopodia. GFP-, YFP-, or mRFP1-ΔGBD-mDia2 (red)-induced filopodia contain filopodial markers, actin, fascin, VASP, and myosin X, but Abi1 is not enriched there. Fascin, which normally localizes throughout the filopodia, is present only in thick... |
PMC2229861_pbio-0050317-g006_17275.jpg | What is the dominant medical problem in this image? | Filopodia Induction by ΔGBD-mDia2(A) Cytoskeletal proteins in ΔGBD-induced filopodia. GFP-, YFP-, or mRFP1-ΔGBD-mDia2 (red)-induced filopodia contain filopodial markers, actin, fascin, VASP, and myosin X, but Abi1 is not enriched there. Fascin, which normally localizes throughout the filopodia, is present only in thick... |
PMC2229861_pbio-0050317-g008_17295.jpg | What is the central feature of this picture? | Initiation of ΔGBD-mDia2–Induced Filopodia in B16F1 Cells(A) Time-lapse sequence shows how linear lamellipodial distribution of GFPΔGBD-mDia2 transforms into a series of dots. Time is shown in minutes:seconds.(B–J) Correlative EM of nascent ΔGBD-mDia2–induced filopodia.(B) Phase contrast of ΔGBD-mDia2–expressing cell o... |
PMC2229861_pbio-0050317-g008_17299.jpg | What is shown in this image? | Initiation of ΔGBD-mDia2–Induced Filopodia in B16F1 Cells(A) Time-lapse sequence shows how linear lamellipodial distribution of GFPΔGBD-mDia2 transforms into a series of dots. Time is shown in minutes:seconds.(B–J) Correlative EM of nascent ΔGBD-mDia2–induced filopodia.(B) Phase contrast of ΔGBD-mDia2–expressing cell o... |
PMC2229861_pbio-0050317-g008_17302.jpg | Can you identify the primary element in this image? | Initiation of ΔGBD-mDia2–Induced Filopodia in B16F1 Cells(A) Time-lapse sequence shows how linear lamellipodial distribution of GFPΔGBD-mDia2 transforms into a series of dots. Time is shown in minutes:seconds.(B–J) Correlative EM of nascent ΔGBD-mDia2–induced filopodia.(B) Phase contrast of ΔGBD-mDia2–expressing cell o... |
PMC2229861_pbio-0050317-g008_17298.jpg | Can you identify the primary element in this image? | Initiation of ΔGBD-mDia2–Induced Filopodia in B16F1 Cells(A) Time-lapse sequence shows how linear lamellipodial distribution of GFPΔGBD-mDia2 transforms into a series of dots. Time is shown in minutes:seconds.(B–J) Correlative EM of nascent ΔGBD-mDia2–induced filopodia.(B) Phase contrast of ΔGBD-mDia2–expressing cell o... |
PMC2229861_pbio-0050317-g008_17297.jpg | What stands out most in this visual? | Initiation of ΔGBD-mDia2–Induced Filopodia in B16F1 Cells(A) Time-lapse sequence shows how linear lamellipodial distribution of GFPΔGBD-mDia2 transforms into a series of dots. Time is shown in minutes:seconds.(B–J) Correlative EM of nascent ΔGBD-mDia2–induced filopodia.(B) Phase contrast of ΔGBD-mDia2–expressing cell o... |
PMC2229861_pbio-0050317-g008_17303.jpg | What is the focal point of this photograph? | Initiation of ΔGBD-mDia2–Induced Filopodia in B16F1 Cells(A) Time-lapse sequence shows how linear lamellipodial distribution of GFPΔGBD-mDia2 transforms into a series of dots. Time is shown in minutes:seconds.(B–J) Correlative EM of nascent ΔGBD-mDia2–induced filopodia.(B) Phase contrast of ΔGBD-mDia2–expressing cell o... |
PMC2229861_pbio-0050317-g008_17296.jpg | What object or scene is depicted here? | Initiation of ΔGBD-mDia2–Induced Filopodia in B16F1 Cells(A) Time-lapse sequence shows how linear lamellipodial distribution of GFPΔGBD-mDia2 transforms into a series of dots. Time is shown in minutes:seconds.(B–J) Correlative EM of nascent ΔGBD-mDia2–induced filopodia.(B) Phase contrast of ΔGBD-mDia2–expressing cell o... |
PMC2229861_pbio-0050317-g008_17305.jpg | What does this image primarily show? | Initiation of ΔGBD-mDia2–Induced Filopodia in B16F1 Cells(A) Time-lapse sequence shows how linear lamellipodial distribution of GFPΔGBD-mDia2 transforms into a series of dots. Time is shown in minutes:seconds.(B–J) Correlative EM of nascent ΔGBD-mDia2–induced filopodia.(B) Phase contrast of ΔGBD-mDia2–expressing cell o... |
PMC2229861_pbio-0050317-g009_17261.jpg | What does this image primarily show? | Targeting of mDia2 to the Leading Edge(A) GFP-FH1FH2-mDia2 in B16F1 cells is not efficiently targeted to the membrane and weakly induces filopodia. GFP fluorescence (top) and F-actin (middle) are enriched throughout the cell. Boxed region is enlarged at right. Contrast enhancement shows some FH1FH2-mDia2 at the tips of... |
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