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PMC1579245_ppat-0020101-g007_7337.jpg | Can you identify the primary element in this image? | BSF-TPN Mutants Proceed through Multiple Rounds of Flagellum Replication, but Ultimately Fail to Initiate CytokinesisImmunofluorescence analysis of BSF-TPN-B cells grown in the absence (A) or presence (B–F) of tetracycline for 24 h. Cytoskeletons were prepared by detergent extraction and used for immunofluorescence with α-PFR-2 (A–F) monoclonal antibodies. Phase-contrast images are shown in the left panels and merged images are shown in the right panels, with antibody staining in red and DAPI staining in blue. Arrowheads indicate examples of cells with more than two flagella and a single diffuse nucleus. Arrows indicate examples of cells with more than two flagella and two or more nuclei. Scalebar is 10 μm. |
PMC1584227_F1_7340.jpg | Can you identify the primary element in this image? | Early postoperative chest radiography showing a normal appearance. |
PMC1584228_F2_7342.jpg | What is the focal point of this photograph? | Photograph of resected 10 cm aneurysm. Note the intramural thrombus |
PMC1584248_F10_7343.jpg | What is the core subject represented in this visual? | Superposition of the transmission and fluorescence image of a pilosebaceous orifice on a 25th removed tape strip stained with OsO4 obtained by laser scanning microscopy, the distribution of titanium dioxide coating inside the mark of a pilosebaceous orifice is seen as red spots. |
PMC1584416_pbio-0040322-g003_7350.jpg | What key item or scene is captured in this photo? | Rescue of TTD-Associated Segmental Progeroid Features in Compound Heterozygous Xpd TTD/†XPCS Mice(A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice. Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice.(B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice. Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right). Note the absence of these features in the XpdTTD / † XPCS mouse.(C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice. The p-values indicate the significance of the difference relative to XpdTTD/TTD. Error bars indicate SEM.(D) Body weight curves as a function of time. Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice. Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks. Error bars indicate SEM. |
PMC1584416_pbio-0040322-g003_7349.jpg | What stands out most in this visual? | Rescue of TTD-Associated Segmental Progeroid Features in Compound Heterozygous Xpd TTD/†XPCS Mice(A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice. Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice.(B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice. Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right). Note the absence of these features in the XpdTTD / † XPCS mouse.(C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice. The p-values indicate the significance of the difference relative to XpdTTD/TTD. Error bars indicate SEM.(D) Body weight curves as a function of time. Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice. Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks. Error bars indicate SEM. |
PMC1584416_pbio-0040322-g003_7347.jpg | Can you identify the primary element in this image? | Rescue of TTD-Associated Segmental Progeroid Features in Compound Heterozygous Xpd TTD/†XPCS Mice(A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice. Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice.(B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice. Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right). Note the absence of these features in the XpdTTD / † XPCS mouse.(C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice. The p-values indicate the significance of the difference relative to XpdTTD/TTD. Error bars indicate SEM.(D) Body weight curves as a function of time. Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice. Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks. Error bars indicate SEM. |
PMC1584416_pbio-0040322-g003_7345.jpg | What is the central feature of this picture? | Rescue of TTD-Associated Segmental Progeroid Features in Compound Heterozygous Xpd TTD/†XPCS Mice(A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice. Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice.(B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice. Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right). Note the absence of these features in the XpdTTD / † XPCS mouse.(C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice. The p-values indicate the significance of the difference relative to XpdTTD/TTD. Error bars indicate SEM.(D) Body weight curves as a function of time. Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice. Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks. Error bars indicate SEM. |
PMC1586012_F2_7351.jpg | What is the principal component of this image? | Ocular fundus aspect of retinoblastoma. |
PMC1586012_F4_7352.jpg | What is the main focus of this visual representation? | MRI pattern of retinoblastoma with optic nerve involvement (sagittal enhanced T1-weighted sequence). |
PMC1586012_F5_7353.jpg | What does this image primarily show? | Aspect of trilateral retinoblastoma (MRI). |
PMC1586028_F5_7354.jpg | What is the focal point of this photograph? | Identification of NFκB-regulated genes by selecting significant correlations between the fold-change values of the genes and Z-scores of V$NFKAPPAB65_01 among multiple data sets. Correlation coefficients were converted into t-scores. Java Treeview was used to represent visually the matrix of t-scores over all TFBSs and genes. Genes that correlated highly with V$NFKAPPAB65_01 are shown. Several TFBSs showing high correlation with genes regulated by V$NFKAPPAB65_01 are marked. |
PMC1586159_F2_7359.jpg | What can you see in this picture? | The Navigant screen. The fluoroscopic images at the bottom (RAO on the left and LAO on the right) can be stored at the start of the procedure, but in this case have been recently updated. The yellow line is the virtual catheter which the software has placed on the image. The blue and white catheter tip is the virtual catheter which the CARTO system places in the Navigant screen. As can be seen the virtual catheter is overlying the actual fluoroscopic catheter shadow. The other features on the screen are aids to navigation. |
PMC1586159_F2_7357.jpg | What can you see in this picture? | The Navigant screen. The fluoroscopic images at the bottom (RAO on the left and LAO on the right) can be stored at the start of the procedure, but in this case have been recently updated. The yellow line is the virtual catheter which the software has placed on the image. The blue and white catheter tip is the virtual catheter which the CARTO system places in the Navigant screen. As can be seen the virtual catheter is overlying the actual fluoroscopic catheter shadow. The other features on the screen are aids to navigation. |
PMC1586159_F2_7358.jpg | Describe the main subject of this image. | The Navigant screen. The fluoroscopic images at the bottom (RAO on the left and LAO on the right) can be stored at the start of the procedure, but in this case have been recently updated. The yellow line is the virtual catheter which the software has placed on the image. The blue and white catheter tip is the virtual catheter which the CARTO system places in the Navigant screen. As can be seen the virtual catheter is overlying the actual fluoroscopic catheter shadow. The other features on the screen are aids to navigation. |
PMC1586159_F6_7362.jpg | What does this image primarily show? | PAIEON - This image again shows the Navigant screen with the reconstruction overlaid on the radiographic images saved during the angiogram. The image above the LAO radiographic image shows the 3D reconstruction and the image above the RAO shows a fly-through image from the reconstruction. This is then used to navigate the magnetically enabled guidewire into the CS side branch. The other features which can be seen are aids to navigation. |
PMC1586159_F6_7366.jpg | What is the central feature of this picture? | PAIEON - This image again shows the Navigant screen with the reconstruction overlaid on the radiographic images saved during the angiogram. The image above the LAO radiographic image shows the 3D reconstruction and the image above the RAO shows a fly-through image from the reconstruction. This is then used to navigate the magnetically enabled guidewire into the CS side branch. The other features which can be seen are aids to navigation. |
PMC1586159_F6_7363.jpg | What is the main focus of this visual representation? | PAIEON - This image again shows the Navigant screen with the reconstruction overlaid on the radiographic images saved during the angiogram. The image above the LAO radiographic image shows the 3D reconstruction and the image above the RAO shows a fly-through image from the reconstruction. This is then used to navigate the magnetically enabled guidewire into the CS side branch. The other features which can be seen are aids to navigation. |
PMC1586159_F6_7365.jpg | What is the main focus of this visual representation? | PAIEON - This image again shows the Navigant screen with the reconstruction overlaid on the radiographic images saved during the angiogram. The image above the LAO radiographic image shows the 3D reconstruction and the image above the RAO shows a fly-through image from the reconstruction. This is then used to navigate the magnetically enabled guidewire into the CS side branch. The other features which can be seen are aids to navigation. |
PMC1586196_F2_7371.jpg | What is the central feature of this picture? | a. Coomassie brilliant blue-stained 12% SDS-PAGE of the nucleocapsid and envelope proteins of WSSV. Lanes: M, low molecular mass protein marker; 1, high-salt treated nucleocapsid sample; 2, low-pH treated nucleocapsid sample. b, c. Western blot analysis with anti-VP51 or VP76 serum respectively. 1, high-salt treated nucleocapsid sample; 2, low-pH treated nucleocapsid sample; 3, envelope fraction after Triton X-100 treatment; 4, nucleocapsid fraction after Triton X-100 treatment. d, e. TEM examination of high-salt or low-pH treated nucleocapsid sample, respectively. Bars, 100 nm. |
PMC1590043_F2_7373.jpg | What stands out most in this visual? | Postoperative MRI. Follow-up MRI at 9 months postoperatively showing normal remaining kidney with scar formation. |
PMC1590045_F4_7375.jpg | What's the most prominent thing you notice in this picture? | Microendoscopic view ×150 showing mucosal surface and underlying capillary network at time "1". No methylene blue stain was used. Here the capillaries are seen to open up and become visible; this is a pulsatile phenomenon in real time. This suggests good flow and perfusion pressure. The procedure may be done intraoperatively and postoperatively via an endoscope. |
PMC1590045_F5_7376.jpg | What stands out most in this visual? | Microendoscopic view ×150 showing serosal surface and underlying capillary network. No methylene blue stain was used. The larger calibre serosal capillaries are easier to visualise, in real time actual cells and flow is visible within the lumen of the vessels. The procedure may be undertaken intraoperatively (during graft setting and before tissue coverage) and on sentinel graft islands postoperatively to assess perfusion. Again time gated image analysis can be performed to provide quantifiable data on blood flow and perfusion with colorimetric analysis possible to assess state of oxygen saturation. |
PMC1592110_F4_7379.jpg | Describe the main subject of this image. | Immunohistochemical stainings of gliomas. Glioma cell proliferation was assessed by immunostaining for Ki67 positive glioma cell nuclei (arrows) in rats implanted with gliomas (a) and in rats co-injected with apyrase (b). The sections were immunostained for VEGF, in rats implanted with gliomas (c) and in rats co-injected with apyrase (d). Scale bars = 20 μm (a,b); 100 μm (c,d). |
PMC1592110_F4_7378.jpg | What key item or scene is captured in this photo? | Immunohistochemical stainings of gliomas. Glioma cell proliferation was assessed by immunostaining for Ki67 positive glioma cell nuclei (arrows) in rats implanted with gliomas (a) and in rats co-injected with apyrase (b). The sections were immunostained for VEGF, in rats implanted with gliomas (c) and in rats co-injected with apyrase (d). Scale bars = 20 μm (a,b); 100 μm (c,d). |
PMC1592110_F4_7380.jpg | What key item or scene is captured in this photo? | Immunohistochemical stainings of gliomas. Glioma cell proliferation was assessed by immunostaining for Ki67 positive glioma cell nuclei (arrows) in rats implanted with gliomas (a) and in rats co-injected with apyrase (b). The sections were immunostained for VEGF, in rats implanted with gliomas (c) and in rats co-injected with apyrase (d). Scale bars = 20 μm (a,b); 100 μm (c,d). |
PMC1592121_F1_7381.jpg | What is the central feature of this picture? | Transoesophageal echocardiography image showing a vegetation on the right coronary cusp of the aortic valve prolapsing during diastole. |
PMC1592122_F4_7383.jpg | What is shown in this image? | Two-dimensional parasternal and color Doppler images at the level of both ventricles that show the noncompacted:compacted wall ratio and how the color enters the intertrabecular recesses. Others abbreviations as before. |
PMC1592122_F4_7382.jpg | What's the most prominent thing you notice in this picture? | Two-dimensional parasternal and color Doppler images at the level of both ventricles that show the noncompacted:compacted wall ratio and how the color enters the intertrabecular recesses. Others abbreviations as before. |
PMC1592239_pgen-0020149-g002_7384.jpg | What does this image primarily show? | Histology of Middle Ear and Nose in Wild-Type and Junbo Mutant MiceImages (a–h) are from 13-d-old postnatal mice and are given with their original magnification (a) Jbo/+ dorsal section of MEC partly filled with exudate ×40, (b) +/+ normal middle ear temporal bone covered with thin mucoperiosteum (arrowheads) ×400, (c) +/+ inflamed middle ear with thickened mucoperiosteum with neutrophil leukocyte infiltrates and neutrophil-rich exudates in the MEC ×400, (d) Jbo/+ middle ear with more severe suppurative exudation into the MEC ×400, (e) Jbo/+ inflamed edematous polyp (arrowhead) of un-resorbed embryonic middle ear connective tissue, tympanic membrane ×100, (f) Jbo/+ MEC lined by ciliated columnar cells (arrowhead) ×600 (g) Jbo/+ MEC lined by basal cells (arrowhead) ×600, (h) Jbo/+ suppurative rhinitis: nasal cavity with suppurative exudate, nasal septum with inflamed nasal mucosa ×200.Images (i–l) are of adult (180-d) Jbo/+ middle ear with chronic suppurative OM; changes include (i) fibrous polyps (arrowheads) ×200, (j) hyperplasia of ciliated epithelial cells (arrowhead) and fibrosis of mucoperiosteum stroma ×400, and (k) fibrous thickening of the tympanic membrane, outer ear canal ×400 compared with (l) normal +/+ tympanic membrane, outer ear canal ×400. E, exudate; MP, mucoperiosteum; NC, nasal cavity; NM, nasal mucosa; NS, nasal septum; OEC, outer ear canal; TB, temporal bone; TM, tympanic membrane |
PMC1592239_pgen-0020149-g002_7391.jpg | Can you identify the primary element in this image? | Histology of Middle Ear and Nose in Wild-Type and Junbo Mutant MiceImages (a–h) are from 13-d-old postnatal mice and are given with their original magnification (a) Jbo/+ dorsal section of MEC partly filled with exudate ×40, (b) +/+ normal middle ear temporal bone covered with thin mucoperiosteum (arrowheads) ×400, (c) +/+ inflamed middle ear with thickened mucoperiosteum with neutrophil leukocyte infiltrates and neutrophil-rich exudates in the MEC ×400, (d) Jbo/+ middle ear with more severe suppurative exudation into the MEC ×400, (e) Jbo/+ inflamed edematous polyp (arrowhead) of un-resorbed embryonic middle ear connective tissue, tympanic membrane ×100, (f) Jbo/+ MEC lined by ciliated columnar cells (arrowhead) ×600 (g) Jbo/+ MEC lined by basal cells (arrowhead) ×600, (h) Jbo/+ suppurative rhinitis: nasal cavity with suppurative exudate, nasal septum with inflamed nasal mucosa ×200.Images (i–l) are of adult (180-d) Jbo/+ middle ear with chronic suppurative OM; changes include (i) fibrous polyps (arrowheads) ×200, (j) hyperplasia of ciliated epithelial cells (arrowhead) and fibrosis of mucoperiosteum stroma ×400, and (k) fibrous thickening of the tympanic membrane, outer ear canal ×400 compared with (l) normal +/+ tympanic membrane, outer ear canal ×400. E, exudate; MP, mucoperiosteum; NC, nasal cavity; NM, nasal mucosa; NS, nasal septum; OEC, outer ear canal; TB, temporal bone; TM, tympanic membrane |
PMC1592239_pgen-0020149-g002_7389.jpg | What stands out most in this visual? | Histology of Middle Ear and Nose in Wild-Type and Junbo Mutant MiceImages (a–h) are from 13-d-old postnatal mice and are given with their original magnification (a) Jbo/+ dorsal section of MEC partly filled with exudate ×40, (b) +/+ normal middle ear temporal bone covered with thin mucoperiosteum (arrowheads) ×400, (c) +/+ inflamed middle ear with thickened mucoperiosteum with neutrophil leukocyte infiltrates and neutrophil-rich exudates in the MEC ×400, (d) Jbo/+ middle ear with more severe suppurative exudation into the MEC ×400, (e) Jbo/+ inflamed edematous polyp (arrowhead) of un-resorbed embryonic middle ear connective tissue, tympanic membrane ×100, (f) Jbo/+ MEC lined by ciliated columnar cells (arrowhead) ×600 (g) Jbo/+ MEC lined by basal cells (arrowhead) ×600, (h) Jbo/+ suppurative rhinitis: nasal cavity with suppurative exudate, nasal septum with inflamed nasal mucosa ×200.Images (i–l) are of adult (180-d) Jbo/+ middle ear with chronic suppurative OM; changes include (i) fibrous polyps (arrowheads) ×200, (j) hyperplasia of ciliated epithelial cells (arrowhead) and fibrosis of mucoperiosteum stroma ×400, and (k) fibrous thickening of the tympanic membrane, outer ear canal ×400 compared with (l) normal +/+ tympanic membrane, outer ear canal ×400. E, exudate; MP, mucoperiosteum; NC, nasal cavity; NM, nasal mucosa; NS, nasal septum; OEC, outer ear canal; TB, temporal bone; TM, tympanic membrane |
PMC1592239_pgen-0020149-g002_7393.jpg | What is the dominant medical problem in this image? | Histology of Middle Ear and Nose in Wild-Type and Junbo Mutant MiceImages (a–h) are from 13-d-old postnatal mice and are given with their original magnification (a) Jbo/+ dorsal section of MEC partly filled with exudate ×40, (b) +/+ normal middle ear temporal bone covered with thin mucoperiosteum (arrowheads) ×400, (c) +/+ inflamed middle ear with thickened mucoperiosteum with neutrophil leukocyte infiltrates and neutrophil-rich exudates in the MEC ×400, (d) Jbo/+ middle ear with more severe suppurative exudation into the MEC ×400, (e) Jbo/+ inflamed edematous polyp (arrowhead) of un-resorbed embryonic middle ear connective tissue, tympanic membrane ×100, (f) Jbo/+ MEC lined by ciliated columnar cells (arrowhead) ×600 (g) Jbo/+ MEC lined by basal cells (arrowhead) ×600, (h) Jbo/+ suppurative rhinitis: nasal cavity with suppurative exudate, nasal septum with inflamed nasal mucosa ×200.Images (i–l) are of adult (180-d) Jbo/+ middle ear with chronic suppurative OM; changes include (i) fibrous polyps (arrowheads) ×200, (j) hyperplasia of ciliated epithelial cells (arrowhead) and fibrosis of mucoperiosteum stroma ×400, and (k) fibrous thickening of the tympanic membrane, outer ear canal ×400 compared with (l) normal +/+ tympanic membrane, outer ear canal ×400. E, exudate; MP, mucoperiosteum; NC, nasal cavity; NM, nasal mucosa; NS, nasal septum; OEC, outer ear canal; TB, temporal bone; TM, tympanic membrane |
PMC1592239_pgen-0020149-g002_7386.jpg | What is the dominant medical problem in this image? | Histology of Middle Ear and Nose in Wild-Type and Junbo Mutant MiceImages (a–h) are from 13-d-old postnatal mice and are given with their original magnification (a) Jbo/+ dorsal section of MEC partly filled with exudate ×40, (b) +/+ normal middle ear temporal bone covered with thin mucoperiosteum (arrowheads) ×400, (c) +/+ inflamed middle ear with thickened mucoperiosteum with neutrophil leukocyte infiltrates and neutrophil-rich exudates in the MEC ×400, (d) Jbo/+ middle ear with more severe suppurative exudation into the MEC ×400, (e) Jbo/+ inflamed edematous polyp (arrowhead) of un-resorbed embryonic middle ear connective tissue, tympanic membrane ×100, (f) Jbo/+ MEC lined by ciliated columnar cells (arrowhead) ×600 (g) Jbo/+ MEC lined by basal cells (arrowhead) ×600, (h) Jbo/+ suppurative rhinitis: nasal cavity with suppurative exudate, nasal septum with inflamed nasal mucosa ×200.Images (i–l) are of adult (180-d) Jbo/+ middle ear with chronic suppurative OM; changes include (i) fibrous polyps (arrowheads) ×200, (j) hyperplasia of ciliated epithelial cells (arrowhead) and fibrosis of mucoperiosteum stroma ×400, and (k) fibrous thickening of the tympanic membrane, outer ear canal ×400 compared with (l) normal +/+ tympanic membrane, outer ear canal ×400. E, exudate; MP, mucoperiosteum; NC, nasal cavity; NM, nasal mucosa; NS, nasal septum; OEC, outer ear canal; TB, temporal bone; TM, tympanic membrane |
PMC1592239_pgen-0020149-g002_7394.jpg | What is being portrayed in this visual content? | Histology of Middle Ear and Nose in Wild-Type and Junbo Mutant MiceImages (a–h) are from 13-d-old postnatal mice and are given with their original magnification (a) Jbo/+ dorsal section of MEC partly filled with exudate ×40, (b) +/+ normal middle ear temporal bone covered with thin mucoperiosteum (arrowheads) ×400, (c) +/+ inflamed middle ear with thickened mucoperiosteum with neutrophil leukocyte infiltrates and neutrophil-rich exudates in the MEC ×400, (d) Jbo/+ middle ear with more severe suppurative exudation into the MEC ×400, (e) Jbo/+ inflamed edematous polyp (arrowhead) of un-resorbed embryonic middle ear connective tissue, tympanic membrane ×100, (f) Jbo/+ MEC lined by ciliated columnar cells (arrowhead) ×600 (g) Jbo/+ MEC lined by basal cells (arrowhead) ×600, (h) Jbo/+ suppurative rhinitis: nasal cavity with suppurative exudate, nasal septum with inflamed nasal mucosa ×200.Images (i–l) are of adult (180-d) Jbo/+ middle ear with chronic suppurative OM; changes include (i) fibrous polyps (arrowheads) ×200, (j) hyperplasia of ciliated epithelial cells (arrowhead) and fibrosis of mucoperiosteum stroma ×400, and (k) fibrous thickening of the tympanic membrane, outer ear canal ×400 compared with (l) normal +/+ tympanic membrane, outer ear canal ×400. E, exudate; MP, mucoperiosteum; NC, nasal cavity; NM, nasal mucosa; NS, nasal septum; OEC, outer ear canal; TB, temporal bone; TM, tympanic membrane |
PMC1592239_pgen-0020149-g002_7387.jpg | What is being portrayed in this visual content? | Histology of Middle Ear and Nose in Wild-Type and Junbo Mutant MiceImages (a–h) are from 13-d-old postnatal mice and are given with their original magnification (a) Jbo/+ dorsal section of MEC partly filled with exudate ×40, (b) +/+ normal middle ear temporal bone covered with thin mucoperiosteum (arrowheads) ×400, (c) +/+ inflamed middle ear with thickened mucoperiosteum with neutrophil leukocyte infiltrates and neutrophil-rich exudates in the MEC ×400, (d) Jbo/+ middle ear with more severe suppurative exudation into the MEC ×400, (e) Jbo/+ inflamed edematous polyp (arrowhead) of un-resorbed embryonic middle ear connective tissue, tympanic membrane ×100, (f) Jbo/+ MEC lined by ciliated columnar cells (arrowhead) ×600 (g) Jbo/+ MEC lined by basal cells (arrowhead) ×600, (h) Jbo/+ suppurative rhinitis: nasal cavity with suppurative exudate, nasal septum with inflamed nasal mucosa ×200.Images (i–l) are of adult (180-d) Jbo/+ middle ear with chronic suppurative OM; changes include (i) fibrous polyps (arrowheads) ×200, (j) hyperplasia of ciliated epithelial cells (arrowhead) and fibrosis of mucoperiosteum stroma ×400, and (k) fibrous thickening of the tympanic membrane, outer ear canal ×400 compared with (l) normal +/+ tympanic membrane, outer ear canal ×400. E, exudate; MP, mucoperiosteum; NC, nasal cavity; NM, nasal mucosa; NS, nasal septum; OEC, outer ear canal; TB, temporal bone; TM, tympanic membrane |
PMC1592301_F3_7396.jpg | What does this image primarily show? | T2 weighted FLAIR images of magnetic resonance scan showing bilaterally symmetrical hyperintensities in Caudate nucleus (small, thin arrow), Putamen (long arrow), with sparing of Globus Pallidus (broad arrow), suggestive of Extrapontine myelinolysis. |
PMC1592472_F3_7399.jpg | What key item or scene is captured in this photo? | Hyper-spectral FTIR data processing performed simultaneously on 4 adjacent tissue sections from a cervical biopsy sample. The numbers 1 through 4 identify the individual sections in the figure. In (a), a univariate chemical image obtained from the integrating the area under the 1275-1190 cm-1 region after baseline subtraction and in (b), a 4 cluster map derived from analysis over the 1272-950 cm-1 spectral window. The cluster map false color scheme corresponds to brown for exudates, blue for inflamed glandular tissue, green for connective tissue and orange for blood filled capillaries as described in the text. |
PMC1592472_F3_7400.jpg | What is the main focus of this visual representation? | Hyper-spectral FTIR data processing performed simultaneously on 4 adjacent tissue sections from a cervical biopsy sample. The numbers 1 through 4 identify the individual sections in the figure. In (a), a univariate chemical image obtained from the integrating the area under the 1275-1190 cm-1 region after baseline subtraction and in (b), a 4 cluster map derived from analysis over the 1272-950 cm-1 spectral window. The cluster map false color scheme corresponds to brown for exudates, blue for inflamed glandular tissue, green for connective tissue and orange for blood filled capillaries as described in the text. |
PMC1592478_F6_7401.jpg | What is the core subject represented in this visual? | Heparin, but not RAP-GST, competes for DiI-apoE-VLDL uptake by GM00701/Syn-1-HA cells. GM00701/Syn-1-HA cells were cultured on glass coverslips and incubated with DiI-labeled apoE-VLDL (4 μg/ml) in the absence (panel A) or presence of recombinant human RAP-GST (50 μg/ml, panel B) or heparin (200 μg/ml, panel C) at 37°C for 3 h. Cells were fixed and processed for fluorescence microscopy. Magnification, 630X. |
PMC1592478_F6_7402.jpg | Can you identify the primary element in this image? | Heparin, but not RAP-GST, competes for DiI-apoE-VLDL uptake by GM00701/Syn-1-HA cells. GM00701/Syn-1-HA cells were cultured on glass coverslips and incubated with DiI-labeled apoE-VLDL (4 μg/ml) in the absence (panel A) or presence of recombinant human RAP-GST (50 μg/ml, panel B) or heparin (200 μg/ml, panel C) at 37°C for 3 h. Cells were fixed and processed for fluorescence microscopy. Magnification, 630X. |
PMC1592478_F6_7403.jpg | What object or scene is depicted here? | Heparin, but not RAP-GST, competes for DiI-apoE-VLDL uptake by GM00701/Syn-1-HA cells. GM00701/Syn-1-HA cells were cultured on glass coverslips and incubated with DiI-labeled apoE-VLDL (4 μg/ml) in the absence (panel A) or presence of recombinant human RAP-GST (50 μg/ml, panel B) or heparin (200 μg/ml, panel C) at 37°C for 3 h. Cells were fixed and processed for fluorescence microscopy. Magnification, 630X. |
PMC1592487_F1_7404.jpg | What is the main focus of this visual representation? | Portal venous phase image of an axial CT cut showing a large heterogeneous cystic mass within the right lobe of the liver centered on segment 5 and 6 and measuring 15 × 17 × 20 cm in maximum dimension. Further cuts show extension to segment 4A and segment 1 encroachment. No direct portal or peri-coeliac lymphadenopathy was identified. |
PMC1592488_F1_7405.jpg | What stands out most in this visual? | MRI showing soft tissue mass involving the upper branches of the brachial plexus. |
PMC1592488_F2_7406.jpg | What is shown in this image? | The open biopsy showing pleomorphic spindle cell sarcoma. |
PMC1592489_F1_7409.jpg | Can you identify the primary element in this image? | Effects of U46619 (10-7 M) and acetylcholine (Ach; 10-5 M) on internal luminal diameter of airway and vessels in whole precision cut lung slices. A; Tissue under control (basal conditions) bathed in medium alone. B; Tissue after 6 min stimulation with U46619. C; Tissue after 5 min stimulation with U46619 and acetylcholine. The images are representative of those used in the pooled data shown in Figure 2. |
PMC1592489_F1_7408.jpg | What is the dominant medical problem in this image? | Effects of U46619 (10-7 M) and acetylcholine (Ach; 10-5 M) on internal luminal diameter of airway and vessels in whole precision cut lung slices. A; Tissue under control (basal conditions) bathed in medium alone. B; Tissue after 6 min stimulation with U46619. C; Tissue after 5 min stimulation with U46619 and acetylcholine. The images are representative of those used in the pooled data shown in Figure 2. |
PMC1592685_F1_7410.jpg | What object or scene is depicted here? | Bicuspid aorta. Anatomic specimen (A) and 3-D reconstruction of echocardiographic images (B) show anterosuperior relationship of aortic leaflets with thickened edges (black arrowheads in A), nodules on the internal aspect (arrows) and lateralized commissures (asterisks). ASV: Anterior leaflet; PSV: Posterior leaflet. |
PMC1599730_F1_7412.jpg | What is the central feature of this picture? | Computed tomography scan of the chest showing the esophageal tumor mass bulging toward the right pleural cavity. |
PMC1599730_F3_7414.jpg | Describe the main subject of this image. | Thoracoscopic findings: (A) The esophageal tumor projects into the right thoracic space; (B) The tumor is enucleated with a simple hook-electrocautery; (C) Trans-illumination from intraopeative esophagoscopy was identified after the tumor was collected in a plastic bag; (D) The tumor was completely removed through camera port in small pieces. |
PMC1599730_F3_7413.jpg | What is the focal point of this photograph? | Thoracoscopic findings: (A) The esophageal tumor projects into the right thoracic space; (B) The tumor is enucleated with a simple hook-electrocautery; (C) Trans-illumination from intraopeative esophagoscopy was identified after the tumor was collected in a plastic bag; (D) The tumor was completely removed through camera port in small pieces. |
PMC1599730_F3_7416.jpg | What is shown in this image? | Thoracoscopic findings: (A) The esophageal tumor projects into the right thoracic space; (B) The tumor is enucleated with a simple hook-electrocautery; (C) Trans-illumination from intraopeative esophagoscopy was identified after the tumor was collected in a plastic bag; (D) The tumor was completely removed through camera port in small pieces. |
PMC1599730_F3_7415.jpg | What is shown in this image? | Thoracoscopic findings: (A) The esophageal tumor projects into the right thoracic space; (B) The tumor is enucleated with a simple hook-electrocautery; (C) Trans-illumination from intraopeative esophagoscopy was identified after the tumor was collected in a plastic bag; (D) The tumor was completely removed through camera port in small pieces. |
PMC1599744_F1_7418.jpg | What is the central feature of this picture? | Angiography of spontaneous perirenal haemorrhage. A, Pre-embolisation. B, Post-embolisation of a branch of renal artery. |
PMC1599744_F2_7419.jpg | What is the focal point of this photograph? | Spontaneous perirenal haemorrhage. A, Computerised tomography showing spontaneous perirenal haemorrhage. B, Angiography Pre-embolisation. C, Angiography Post-embolisation. |
PMC1599744_F2_7421.jpg | What is the core subject represented in this visual? | Spontaneous perirenal haemorrhage. A, Computerised tomography showing spontaneous perirenal haemorrhage. B, Angiography Pre-embolisation. C, Angiography Post-embolisation. |
PMC1599744_F3_7423.jpg | What is being portrayed in this visual content? | Angiography post transurethral resection of bladder tumour. A, Pre-embolisation. B, Post-embolisation of anterior division of internal iliac artery. |
PMC1599744_F3_7422.jpg | What is the principal component of this image? | Angiography post transurethral resection of bladder tumour. A, Pre-embolisation. B, Post-embolisation of anterior division of internal iliac artery. |
PMC1599746_F3_7425.jpg | Describe the main subject of this image. | Conventional HLA immunohistochemistry of formalin-fixed paraffin-embedded tissue. Using HCA2 (HLA-A heavy chain), HC10 (HLA-B/C heavy chain) and anti-B2M antibodies, loss of HLA A and B expression as detected by flow cytometry (see Figures 1 and 2) could be confirmed. In the top panel, membranous staining (arrows) of B2M, HCA2, and HC10 is observed in the moderately differentiated sigmoid adenocarcinoma of case 122. In the bottom panel, loss of HLA-A and -B is illustrated for the mucinous caecum adenocarcinoma of case 179. Tumor B2M staining was mainly restricted to the cytoplasm (arrow), but some membranous expression of B2M was observed by FCM (see Figure 1). The HCA2 and HC10 staining was completely lost in tumor epithelium (t). Typically, the retained HLA expression of stroma cells (s) resulted in an inverted staining pattern in comparison to case 122. HE, haematoxylin and eosin staining. Pictures were made at 400 × magnification, HEs at 100×. |
PMC1599746_F3_7430.jpg | What key item or scene is captured in this photo? | Conventional HLA immunohistochemistry of formalin-fixed paraffin-embedded tissue. Using HCA2 (HLA-A heavy chain), HC10 (HLA-B/C heavy chain) and anti-B2M antibodies, loss of HLA A and B expression as detected by flow cytometry (see Figures 1 and 2) could be confirmed. In the top panel, membranous staining (arrows) of B2M, HCA2, and HC10 is observed in the moderately differentiated sigmoid adenocarcinoma of case 122. In the bottom panel, loss of HLA-A and -B is illustrated for the mucinous caecum adenocarcinoma of case 179. Tumor B2M staining was mainly restricted to the cytoplasm (arrow), but some membranous expression of B2M was observed by FCM (see Figure 1). The HCA2 and HC10 staining was completely lost in tumor epithelium (t). Typically, the retained HLA expression of stroma cells (s) resulted in an inverted staining pattern in comparison to case 122. HE, haematoxylin and eosin staining. Pictures were made at 400 × magnification, HEs at 100×. |
PMC1599746_F3_7429.jpg | What stands out most in this visual? | Conventional HLA immunohistochemistry of formalin-fixed paraffin-embedded tissue. Using HCA2 (HLA-A heavy chain), HC10 (HLA-B/C heavy chain) and anti-B2M antibodies, loss of HLA A and B expression as detected by flow cytometry (see Figures 1 and 2) could be confirmed. In the top panel, membranous staining (arrows) of B2M, HCA2, and HC10 is observed in the moderately differentiated sigmoid adenocarcinoma of case 122. In the bottom panel, loss of HLA-A and -B is illustrated for the mucinous caecum adenocarcinoma of case 179. Tumor B2M staining was mainly restricted to the cytoplasm (arrow), but some membranous expression of B2M was observed by FCM (see Figure 1). The HCA2 and HC10 staining was completely lost in tumor epithelium (t). Typically, the retained HLA expression of stroma cells (s) resulted in an inverted staining pattern in comparison to case 122. HE, haematoxylin and eosin staining. Pictures were made at 400 × magnification, HEs at 100×. |
PMC1599746_F3_7431.jpg | What key item or scene is captured in this photo? | Conventional HLA immunohistochemistry of formalin-fixed paraffin-embedded tissue. Using HCA2 (HLA-A heavy chain), HC10 (HLA-B/C heavy chain) and anti-B2M antibodies, loss of HLA A and B expression as detected by flow cytometry (see Figures 1 and 2) could be confirmed. In the top panel, membranous staining (arrows) of B2M, HCA2, and HC10 is observed in the moderately differentiated sigmoid adenocarcinoma of case 122. In the bottom panel, loss of HLA-A and -B is illustrated for the mucinous caecum adenocarcinoma of case 179. Tumor B2M staining was mainly restricted to the cytoplasm (arrow), but some membranous expression of B2M was observed by FCM (see Figure 1). The HCA2 and HC10 staining was completely lost in tumor epithelium (t). Typically, the retained HLA expression of stroma cells (s) resulted in an inverted staining pattern in comparison to case 122. HE, haematoxylin and eosin staining. Pictures were made at 400 × magnification, HEs at 100×. |
PMC1599746_F3_7427.jpg | What object or scene is depicted here? | Conventional HLA immunohistochemistry of formalin-fixed paraffin-embedded tissue. Using HCA2 (HLA-A heavy chain), HC10 (HLA-B/C heavy chain) and anti-B2M antibodies, loss of HLA A and B expression as detected by flow cytometry (see Figures 1 and 2) could be confirmed. In the top panel, membranous staining (arrows) of B2M, HCA2, and HC10 is observed in the moderately differentiated sigmoid adenocarcinoma of case 122. In the bottom panel, loss of HLA-A and -B is illustrated for the mucinous caecum adenocarcinoma of case 179. Tumor B2M staining was mainly restricted to the cytoplasm (arrow), but some membranous expression of B2M was observed by FCM (see Figure 1). The HCA2 and HC10 staining was completely lost in tumor epithelium (t). Typically, the retained HLA expression of stroma cells (s) resulted in an inverted staining pattern in comparison to case 122. HE, haematoxylin and eosin staining. Pictures were made at 400 × magnification, HEs at 100×. |
PMC1601950_F1_7433.jpg | What object or scene is depicted here? | Otoscopic images of bilateral spontaneous hemotympanum, after intake of anticoagulants. Upper: hemotympanum of the left ear; lower: hemotympamum of the right ear. |
PMC1601950_F2_7432.jpg | What is the dominant medical problem in this image? | CT scan of the mastoid demonstrating bilateral opacity of the tympanic cavity (white arrows). |
PMC1609104_F2_7435.jpg | What is the core subject represented in this visual? | Histology figure. Numerous secondary lymphoid follicles (Haematoxylin and eosin, original magnification: × 40). |
PMC1609104_F5_7436.jpg | What stands out most in this visual? | Immunohistochemistry figure. CD20 positive lymphoid follicles reflecting the B-Cell nature of the inflammatory cells (Haematoxylin and eosin, original magnification: × 40). |
PMC1609129_pbio-0040340-g002_7441.jpg | What's the most prominent thing you notice in this picture? | Adoptively Transferred T Cells Induce Arthritic Pathology in Recipient Mice(A) X-ray radiographs of fore limbs and (B) and hind limbs comparing mPCC,CD3ɛ −/− mice without a T cell transfer (left panels) and one 86 d after (right panels).(C–E) Hindlimbs from mPCC,CD3ɛ −/− mice were sectioned and stained by HEMATOXYLIN AND EOSIN before (C) T cell transfer and 14 d (D) or 60 d (E) afterward. Lower panels show magnification of the joint regions from the top panels, to illustrate cellular infiltrates in the tibiotarsal region.(F) Clinical scores quantitate increased limb pathology in transfer recipients on a scale of 0 to 56. Bars represent arithmetic means in each group. |
PMC1609129_pbio-0040340-g002_7445.jpg | What stands out most in this visual? | Adoptively Transferred T Cells Induce Arthritic Pathology in Recipient Mice(A) X-ray radiographs of fore limbs and (B) and hind limbs comparing mPCC,CD3ɛ −/− mice without a T cell transfer (left panels) and one 86 d after (right panels).(C–E) Hindlimbs from mPCC,CD3ɛ −/− mice were sectioned and stained by HEMATOXYLIN AND EOSIN before (C) T cell transfer and 14 d (D) or 60 d (E) afterward. Lower panels show magnification of the joint regions from the top panels, to illustrate cellular infiltrates in the tibiotarsal region.(F) Clinical scores quantitate increased limb pathology in transfer recipients on a scale of 0 to 56. Bars represent arithmetic means in each group. |
PMC1609129_pbio-0040340-g002_7440.jpg | What is the central feature of this picture? | Adoptively Transferred T Cells Induce Arthritic Pathology in Recipient Mice(A) X-ray radiographs of fore limbs and (B) and hind limbs comparing mPCC,CD3ɛ −/− mice without a T cell transfer (left panels) and one 86 d after (right panels).(C–E) Hindlimbs from mPCC,CD3ɛ −/− mice were sectioned and stained by HEMATOXYLIN AND EOSIN before (C) T cell transfer and 14 d (D) or 60 d (E) afterward. Lower panels show magnification of the joint regions from the top panels, to illustrate cellular infiltrates in the tibiotarsal region.(F) Clinical scores quantitate increased limb pathology in transfer recipients on a scale of 0 to 56. Bars represent arithmetic means in each group. |
PMC1609129_pbio-0040340-g002_7444.jpg | What is the main focus of this visual representation? | Adoptively Transferred T Cells Induce Arthritic Pathology in Recipient Mice(A) X-ray radiographs of fore limbs and (B) and hind limbs comparing mPCC,CD3ɛ −/− mice without a T cell transfer (left panels) and one 86 d after (right panels).(C–E) Hindlimbs from mPCC,CD3ɛ −/− mice were sectioned and stained by HEMATOXYLIN AND EOSIN before (C) T cell transfer and 14 d (D) or 60 d (E) afterward. Lower panels show magnification of the joint regions from the top panels, to illustrate cellular infiltrates in the tibiotarsal region.(F) Clinical scores quantitate increased limb pathology in transfer recipients on a scale of 0 to 56. Bars represent arithmetic means in each group. |
PMC1609129_pbio-0040340-g002_7446.jpg | What does this image primarily show? | Adoptively Transferred T Cells Induce Arthritic Pathology in Recipient Mice(A) X-ray radiographs of fore limbs and (B) and hind limbs comparing mPCC,CD3ɛ −/− mice without a T cell transfer (left panels) and one 86 d after (right panels).(C–E) Hindlimbs from mPCC,CD3ɛ −/− mice were sectioned and stained by HEMATOXYLIN AND EOSIN before (C) T cell transfer and 14 d (D) or 60 d (E) afterward. Lower panels show magnification of the joint regions from the top panels, to illustrate cellular infiltrates in the tibiotarsal region.(F) Clinical scores quantitate increased limb pathology in transfer recipients on a scale of 0 to 56. Bars represent arithmetic means in each group. |
PMC1609129_pbio-0040340-g002_7438.jpg | What's the most prominent thing you notice in this picture? | Adoptively Transferred T Cells Induce Arthritic Pathology in Recipient Mice(A) X-ray radiographs of fore limbs and (B) and hind limbs comparing mPCC,CD3ɛ −/− mice without a T cell transfer (left panels) and one 86 d after (right panels).(C–E) Hindlimbs from mPCC,CD3ɛ −/− mice were sectioned and stained by HEMATOXYLIN AND EOSIN before (C) T cell transfer and 14 d (D) or 60 d (E) afterward. Lower panels show magnification of the joint regions from the top panels, to illustrate cellular infiltrates in the tibiotarsal region.(F) Clinical scores quantitate increased limb pathology in transfer recipients on a scale of 0 to 56. Bars represent arithmetic means in each group. |
PMC1609129_pbio-0040340-g002_7443.jpg | Describe the main subject of this image. | Adoptively Transferred T Cells Induce Arthritic Pathology in Recipient Mice(A) X-ray radiographs of fore limbs and (B) and hind limbs comparing mPCC,CD3ɛ −/− mice without a T cell transfer (left panels) and one 86 d after (right panels).(C–E) Hindlimbs from mPCC,CD3ɛ −/− mice were sectioned and stained by HEMATOXYLIN AND EOSIN before (C) T cell transfer and 14 d (D) or 60 d (E) afterward. Lower panels show magnification of the joint regions from the top panels, to illustrate cellular infiltrates in the tibiotarsal region.(F) Clinical scores quantitate increased limb pathology in transfer recipients on a scale of 0 to 56. Bars represent arithmetic means in each group. |
PMC1609167_F6_7452.jpg | What is the focal point of this photograph? | Expression of ZmPti1a:GFP fusions in maize pollen. Transgenic maize lines ectopically expressing wild type ZmPti1a:GFP, Myr:GFP or ΔZmPti1a:GFP (see legend Fig. 2) were generated by biolistic transformation. Immature and mature pollen of segregating plants were harvested between 8 dba and anthesis and examined by epifluorescence microscopy. non-transgenic pollen (n-t); vacuole (v); vegetative nucleus (n); generative nucleus (g), septum (s); pollen apertures are indicated by arrows. (A) ZmPti1a:GFP expression in segregating pollen 6 dba. (B) Myr:GFP expression in segregating pollen 6 dba. (C) ΔZmPti1a:GFP expression in segregating pollen 6 dba. (D-F) ZmPti1a:GFP expresed in trinucleate pollen. GFP fluorescence is visible as an annulus-ring structure adjacent to or surrounding the pollen pore. (G, H) GFP fluorescence (top) and decolorized aniline blue staining (bottom) of ZmPti1a:GFP expressing trinucleate pollen. (I) Immature binucleate pollen expressing ΔZmPti1a:GFP. GFP expression is visible in the cytoplasm and the vegetative nucleus but not in the generative cell (left); bright field image of the same pollen (right). (J) Trinucleate pollen of wild type line H99 stained with decolorized aniline blue and showing callose deposition as annulus-ring structure adjacent to the pore. (K) Tube of in vitro germinated ZmPti1a:GFP pollen on PGM showing GFP epifluorescence bordering a callose plug (p); black arrow: direction of pollen tube growth; bottom: bright field image. (L) Decolorized aniline blue staining (left) and bright field image (right) of in vitro germinated A188 pollen with callose plugs (p). Scale bars in panels A – E, K, L = 50 μm; panels F – J = 20 μm |
PMC1609167_F6_7450.jpg | What is the central feature of this picture? | Expression of ZmPti1a:GFP fusions in maize pollen. Transgenic maize lines ectopically expressing wild type ZmPti1a:GFP, Myr:GFP or ΔZmPti1a:GFP (see legend Fig. 2) were generated by biolistic transformation. Immature and mature pollen of segregating plants were harvested between 8 dba and anthesis and examined by epifluorescence microscopy. non-transgenic pollen (n-t); vacuole (v); vegetative nucleus (n); generative nucleus (g), septum (s); pollen apertures are indicated by arrows. (A) ZmPti1a:GFP expression in segregating pollen 6 dba. (B) Myr:GFP expression in segregating pollen 6 dba. (C) ΔZmPti1a:GFP expression in segregating pollen 6 dba. (D-F) ZmPti1a:GFP expresed in trinucleate pollen. GFP fluorescence is visible as an annulus-ring structure adjacent to or surrounding the pollen pore. (G, H) GFP fluorescence (top) and decolorized aniline blue staining (bottom) of ZmPti1a:GFP expressing trinucleate pollen. (I) Immature binucleate pollen expressing ΔZmPti1a:GFP. GFP expression is visible in the cytoplasm and the vegetative nucleus but not in the generative cell (left); bright field image of the same pollen (right). (J) Trinucleate pollen of wild type line H99 stained with decolorized aniline blue and showing callose deposition as annulus-ring structure adjacent to the pore. (K) Tube of in vitro germinated ZmPti1a:GFP pollen on PGM showing GFP epifluorescence bordering a callose plug (p); black arrow: direction of pollen tube growth; bottom: bright field image. (L) Decolorized aniline blue staining (left) and bright field image (right) of in vitro germinated A188 pollen with callose plugs (p). Scale bars in panels A – E, K, L = 50 μm; panels F – J = 20 μm |
PMC1609167_F6_7449.jpg | What is the principal component of this image? | Expression of ZmPti1a:GFP fusions in maize pollen. Transgenic maize lines ectopically expressing wild type ZmPti1a:GFP, Myr:GFP or ΔZmPti1a:GFP (see legend Fig. 2) were generated by biolistic transformation. Immature and mature pollen of segregating plants were harvested between 8 dba and anthesis and examined by epifluorescence microscopy. non-transgenic pollen (n-t); vacuole (v); vegetative nucleus (n); generative nucleus (g), septum (s); pollen apertures are indicated by arrows. (A) ZmPti1a:GFP expression in segregating pollen 6 dba. (B) Myr:GFP expression in segregating pollen 6 dba. (C) ΔZmPti1a:GFP expression in segregating pollen 6 dba. (D-F) ZmPti1a:GFP expresed in trinucleate pollen. GFP fluorescence is visible as an annulus-ring structure adjacent to or surrounding the pollen pore. (G, H) GFP fluorescence (top) and decolorized aniline blue staining (bottom) of ZmPti1a:GFP expressing trinucleate pollen. (I) Immature binucleate pollen expressing ΔZmPti1a:GFP. GFP expression is visible in the cytoplasm and the vegetative nucleus but not in the generative cell (left); bright field image of the same pollen (right). (J) Trinucleate pollen of wild type line H99 stained with decolorized aniline blue and showing callose deposition as annulus-ring structure adjacent to the pore. (K) Tube of in vitro germinated ZmPti1a:GFP pollen on PGM showing GFP epifluorescence bordering a callose plug (p); black arrow: direction of pollen tube growth; bottom: bright field image. (L) Decolorized aniline blue staining (left) and bright field image (right) of in vitro germinated A188 pollen with callose plugs (p). Scale bars in panels A – E, K, L = 50 μm; panels F – J = 20 μm |
PMC1609167_F6_7457.jpg | Can you identify the primary element in this image? | Expression of ZmPti1a:GFP fusions in maize pollen. Transgenic maize lines ectopically expressing wild type ZmPti1a:GFP, Myr:GFP or ΔZmPti1a:GFP (see legend Fig. 2) were generated by biolistic transformation. Immature and mature pollen of segregating plants were harvested between 8 dba and anthesis and examined by epifluorescence microscopy. non-transgenic pollen (n-t); vacuole (v); vegetative nucleus (n); generative nucleus (g), septum (s); pollen apertures are indicated by arrows. (A) ZmPti1a:GFP expression in segregating pollen 6 dba. (B) Myr:GFP expression in segregating pollen 6 dba. (C) ΔZmPti1a:GFP expression in segregating pollen 6 dba. (D-F) ZmPti1a:GFP expresed in trinucleate pollen. GFP fluorescence is visible as an annulus-ring structure adjacent to or surrounding the pollen pore. (G, H) GFP fluorescence (top) and decolorized aniline blue staining (bottom) of ZmPti1a:GFP expressing trinucleate pollen. (I) Immature binucleate pollen expressing ΔZmPti1a:GFP. GFP expression is visible in the cytoplasm and the vegetative nucleus but not in the generative cell (left); bright field image of the same pollen (right). (J) Trinucleate pollen of wild type line H99 stained with decolorized aniline blue and showing callose deposition as annulus-ring structure adjacent to the pore. (K) Tube of in vitro germinated ZmPti1a:GFP pollen on PGM showing GFP epifluorescence bordering a callose plug (p); black arrow: direction of pollen tube growth; bottom: bright field image. (L) Decolorized aniline blue staining (left) and bright field image (right) of in vitro germinated A188 pollen with callose plugs (p). Scale bars in panels A – E, K, L = 50 μm; panels F – J = 20 μm |
PMC1609167_F6_7456.jpg | Describe the main subject of this image. | Expression of ZmPti1a:GFP fusions in maize pollen. Transgenic maize lines ectopically expressing wild type ZmPti1a:GFP, Myr:GFP or ΔZmPti1a:GFP (see legend Fig. 2) were generated by biolistic transformation. Immature and mature pollen of segregating plants were harvested between 8 dba and anthesis and examined by epifluorescence microscopy. non-transgenic pollen (n-t); vacuole (v); vegetative nucleus (n); generative nucleus (g), septum (s); pollen apertures are indicated by arrows. (A) ZmPti1a:GFP expression in segregating pollen 6 dba. (B) Myr:GFP expression in segregating pollen 6 dba. (C) ΔZmPti1a:GFP expression in segregating pollen 6 dba. (D-F) ZmPti1a:GFP expresed in trinucleate pollen. GFP fluorescence is visible as an annulus-ring structure adjacent to or surrounding the pollen pore. (G, H) GFP fluorescence (top) and decolorized aniline blue staining (bottom) of ZmPti1a:GFP expressing trinucleate pollen. (I) Immature binucleate pollen expressing ΔZmPti1a:GFP. GFP expression is visible in the cytoplasm and the vegetative nucleus but not in the generative cell (left); bright field image of the same pollen (right). (J) Trinucleate pollen of wild type line H99 stained with decolorized aniline blue and showing callose deposition as annulus-ring structure adjacent to the pore. (K) Tube of in vitro germinated ZmPti1a:GFP pollen on PGM showing GFP epifluorescence bordering a callose plug (p); black arrow: direction of pollen tube growth; bottom: bright field image. (L) Decolorized aniline blue staining (left) and bright field image (right) of in vitro germinated A188 pollen with callose plugs (p). Scale bars in panels A – E, K, L = 50 μm; panels F – J = 20 μm |
PMC1609167_F6_7447.jpg | What object or scene is depicted here? | Expression of ZmPti1a:GFP fusions in maize pollen. Transgenic maize lines ectopically expressing wild type ZmPti1a:GFP, Myr:GFP or ΔZmPti1a:GFP (see legend Fig. 2) were generated by biolistic transformation. Immature and mature pollen of segregating plants were harvested between 8 dba and anthesis and examined by epifluorescence microscopy. non-transgenic pollen (n-t); vacuole (v); vegetative nucleus (n); generative nucleus (g), septum (s); pollen apertures are indicated by arrows. (A) ZmPti1a:GFP expression in segregating pollen 6 dba. (B) Myr:GFP expression in segregating pollen 6 dba. (C) ΔZmPti1a:GFP expression in segregating pollen 6 dba. (D-F) ZmPti1a:GFP expresed in trinucleate pollen. GFP fluorescence is visible as an annulus-ring structure adjacent to or surrounding the pollen pore. (G, H) GFP fluorescence (top) and decolorized aniline blue staining (bottom) of ZmPti1a:GFP expressing trinucleate pollen. (I) Immature binucleate pollen expressing ΔZmPti1a:GFP. GFP expression is visible in the cytoplasm and the vegetative nucleus but not in the generative cell (left); bright field image of the same pollen (right). (J) Trinucleate pollen of wild type line H99 stained with decolorized aniline blue and showing callose deposition as annulus-ring structure adjacent to the pore. (K) Tube of in vitro germinated ZmPti1a:GFP pollen on PGM showing GFP epifluorescence bordering a callose plug (p); black arrow: direction of pollen tube growth; bottom: bright field image. (L) Decolorized aniline blue staining (left) and bright field image (right) of in vitro germinated A188 pollen with callose plugs (p). Scale bars in panels A – E, K, L = 50 μm; panels F – J = 20 μm |
PMC1609167_F6_7459.jpg | What is the main focus of this visual representation? | Expression of ZmPti1a:GFP fusions in maize pollen. Transgenic maize lines ectopically expressing wild type ZmPti1a:GFP, Myr:GFP or ΔZmPti1a:GFP (see legend Fig. 2) were generated by biolistic transformation. Immature and mature pollen of segregating plants were harvested between 8 dba and anthesis and examined by epifluorescence microscopy. non-transgenic pollen (n-t); vacuole (v); vegetative nucleus (n); generative nucleus (g), septum (s); pollen apertures are indicated by arrows. (A) ZmPti1a:GFP expression in segregating pollen 6 dba. (B) Myr:GFP expression in segregating pollen 6 dba. (C) ΔZmPti1a:GFP expression in segregating pollen 6 dba. (D-F) ZmPti1a:GFP expresed in trinucleate pollen. GFP fluorescence is visible as an annulus-ring structure adjacent to or surrounding the pollen pore. (G, H) GFP fluorescence (top) and decolorized aniline blue staining (bottom) of ZmPti1a:GFP expressing trinucleate pollen. (I) Immature binucleate pollen expressing ΔZmPti1a:GFP. GFP expression is visible in the cytoplasm and the vegetative nucleus but not in the generative cell (left); bright field image of the same pollen (right). (J) Trinucleate pollen of wild type line H99 stained with decolorized aniline blue and showing callose deposition as annulus-ring structure adjacent to the pore. (K) Tube of in vitro germinated ZmPti1a:GFP pollen on PGM showing GFP epifluorescence bordering a callose plug (p); black arrow: direction of pollen tube growth; bottom: bright field image. (L) Decolorized aniline blue staining (left) and bright field image (right) of in vitro germinated A188 pollen with callose plugs (p). Scale bars in panels A – E, K, L = 50 μm; panels F – J = 20 μm |
PMC1613251_F4_7465.jpg | What's the most prominent thing you notice in this picture? | Immunhistochemical analysis of PTTG. Exemplary PTTG staining of a primary tumor of a patient (pT1N0M0), who did not develop a tumor recurrence within the observation period (a). Staining of a primary tumor of a patient (pT1N0M0) who developed a tumor recurrence 24 months after primary tumor resection (c). (e) PTTG staining in the tumor recurrence of the same patient. (b, d and f) corresponding control sections after IgG staining. |
PMC1613251_F4_7463.jpg | What is the main focus of this visual representation? | Immunhistochemical analysis of PTTG. Exemplary PTTG staining of a primary tumor of a patient (pT1N0M0), who did not develop a tumor recurrence within the observation period (a). Staining of a primary tumor of a patient (pT1N0M0) who developed a tumor recurrence 24 months after primary tumor resection (c). (e) PTTG staining in the tumor recurrence of the same patient. (b, d and f) corresponding control sections after IgG staining. |
PMC1613251_F4_7462.jpg | Describe the main subject of this image. | Immunhistochemical analysis of PTTG. Exemplary PTTG staining of a primary tumor of a patient (pT1N0M0), who did not develop a tumor recurrence within the observation period (a). Staining of a primary tumor of a patient (pT1N0M0) who developed a tumor recurrence 24 months after primary tumor resection (c). (e) PTTG staining in the tumor recurrence of the same patient. (b, d and f) corresponding control sections after IgG staining. |
PMC1613251_F4_7464.jpg | What key item or scene is captured in this photo? | Immunhistochemical analysis of PTTG. Exemplary PTTG staining of a primary tumor of a patient (pT1N0M0), who did not develop a tumor recurrence within the observation period (a). Staining of a primary tumor of a patient (pT1N0M0) who developed a tumor recurrence 24 months after primary tumor resection (c). (e) PTTG staining in the tumor recurrence of the same patient. (b, d and f) corresponding control sections after IgG staining. |
PMC1613251_F4_7461.jpg | What is the main focus of this visual representation? | Immunhistochemical analysis of PTTG. Exemplary PTTG staining of a primary tumor of a patient (pT1N0M0), who did not develop a tumor recurrence within the observation period (a). Staining of a primary tumor of a patient (pT1N0M0) who developed a tumor recurrence 24 months after primary tumor resection (c). (e) PTTG staining in the tumor recurrence of the same patient. (b, d and f) corresponding control sections after IgG staining. |
PMC1615870_F6_7472.jpg | What stands out most in this visual? | Serotonergic nervous system development in P. lamarckii. Scale bars = 50 μm. Apical is to the top of the figure in each panel unless indicated. A. Gastrula, left lateral view. One posterior cell (psc) is highly reactive for anti-serotonin. Another cell in the vicinity of the mouth is also reactive (*). Very faint, scattered fluorescent signal marks the beginning of formation of nerve fibres. B. Early trochophore, left lateral view. The posterior serotonergic cell sends processes apically. These fibres are the rudiments of the ventral nerve cords (vnc) and associate with processes that innervate the prototroch nerve ring (pnr). Fibres encircle the mouth (m). The second serotonergic cell (*) now lies posterior to the mouth and is associated with the suboesophageal ganglion.C. Early trochophore, left lateral view. The prototroch nerve ring is complete and runs behind the stomach (st). The neuropil has begun to appear in the apical organ (ao). Some gut autofluorescence is visible. D. Complete trochophore, left lateral view. A metatroch nerve ring appears (mnr). Some gut autofluorescence is visible. E. Elongating trochophore, left lateral view. The cerebral ganglion (cg) is developing and is connected to the ventral nerve cords by the circumoesophageal connectives (cc). The prototroch nerve ring now consists of multiple fibres. Serotonergic cells near the anus are connected to the ventral nerve cords by small fibres (arrow). F. Metatrochophore, ventral view. The paired ventral nerve cords gain commissures and converge posteriorly (arrowhead). Circular nerves can be seen in the periphery of each segment (arrows). Chaetae are autofluorescent. G. Juvenile, ventral view, anterior is to the top. The branchial nerves (bn) and opercular nerve net (onn) are serotonergic. A serotonergic fibre can be seen running along the intestine (arrowhead). Chaetae and uncini are autofluorescent. |
PMC1615870_F6_7471.jpg | What is the central feature of this picture? | Serotonergic nervous system development in P. lamarckii. Scale bars = 50 μm. Apical is to the top of the figure in each panel unless indicated. A. Gastrula, left lateral view. One posterior cell (psc) is highly reactive for anti-serotonin. Another cell in the vicinity of the mouth is also reactive (*). Very faint, scattered fluorescent signal marks the beginning of formation of nerve fibres. B. Early trochophore, left lateral view. The posterior serotonergic cell sends processes apically. These fibres are the rudiments of the ventral nerve cords (vnc) and associate with processes that innervate the prototroch nerve ring (pnr). Fibres encircle the mouth (m). The second serotonergic cell (*) now lies posterior to the mouth and is associated with the suboesophageal ganglion.C. Early trochophore, left lateral view. The prototroch nerve ring is complete and runs behind the stomach (st). The neuropil has begun to appear in the apical organ (ao). Some gut autofluorescence is visible. D. Complete trochophore, left lateral view. A metatroch nerve ring appears (mnr). Some gut autofluorescence is visible. E. Elongating trochophore, left lateral view. The cerebral ganglion (cg) is developing and is connected to the ventral nerve cords by the circumoesophageal connectives (cc). The prototroch nerve ring now consists of multiple fibres. Serotonergic cells near the anus are connected to the ventral nerve cords by small fibres (arrow). F. Metatrochophore, ventral view. The paired ventral nerve cords gain commissures and converge posteriorly (arrowhead). Circular nerves can be seen in the periphery of each segment (arrows). Chaetae are autofluorescent. G. Juvenile, ventral view, anterior is to the top. The branchial nerves (bn) and opercular nerve net (onn) are serotonergic. A serotonergic fibre can be seen running along the intestine (arrowhead). Chaetae and uncini are autofluorescent. |
PMC1615870_F6_7469.jpg | What can you see in this picture? | Serotonergic nervous system development in P. lamarckii. Scale bars = 50 μm. Apical is to the top of the figure in each panel unless indicated. A. Gastrula, left lateral view. One posterior cell (psc) is highly reactive for anti-serotonin. Another cell in the vicinity of the mouth is also reactive (*). Very faint, scattered fluorescent signal marks the beginning of formation of nerve fibres. B. Early trochophore, left lateral view. The posterior serotonergic cell sends processes apically. These fibres are the rudiments of the ventral nerve cords (vnc) and associate with processes that innervate the prototroch nerve ring (pnr). Fibres encircle the mouth (m). The second serotonergic cell (*) now lies posterior to the mouth and is associated with the suboesophageal ganglion.C. Early trochophore, left lateral view. The prototroch nerve ring is complete and runs behind the stomach (st). The neuropil has begun to appear in the apical organ (ao). Some gut autofluorescence is visible. D. Complete trochophore, left lateral view. A metatroch nerve ring appears (mnr). Some gut autofluorescence is visible. E. Elongating trochophore, left lateral view. The cerebral ganglion (cg) is developing and is connected to the ventral nerve cords by the circumoesophageal connectives (cc). The prototroch nerve ring now consists of multiple fibres. Serotonergic cells near the anus are connected to the ventral nerve cords by small fibres (arrow). F. Metatrochophore, ventral view. The paired ventral nerve cords gain commissures and converge posteriorly (arrowhead). Circular nerves can be seen in the periphery of each segment (arrows). Chaetae are autofluorescent. G. Juvenile, ventral view, anterior is to the top. The branchial nerves (bn) and opercular nerve net (onn) are serotonergic. A serotonergic fibre can be seen running along the intestine (arrowhead). Chaetae and uncini are autofluorescent. |
PMC1615870_F6_7468.jpg | What is the dominant medical problem in this image? | Serotonergic nervous system development in P. lamarckii. Scale bars = 50 μm. Apical is to the top of the figure in each panel unless indicated. A. Gastrula, left lateral view. One posterior cell (psc) is highly reactive for anti-serotonin. Another cell in the vicinity of the mouth is also reactive (*). Very faint, scattered fluorescent signal marks the beginning of formation of nerve fibres. B. Early trochophore, left lateral view. The posterior serotonergic cell sends processes apically. These fibres are the rudiments of the ventral nerve cords (vnc) and associate with processes that innervate the prototroch nerve ring (pnr). Fibres encircle the mouth (m). The second serotonergic cell (*) now lies posterior to the mouth and is associated with the suboesophageal ganglion.C. Early trochophore, left lateral view. The prototroch nerve ring is complete and runs behind the stomach (st). The neuropil has begun to appear in the apical organ (ao). Some gut autofluorescence is visible. D. Complete trochophore, left lateral view. A metatroch nerve ring appears (mnr). Some gut autofluorescence is visible. E. Elongating trochophore, left lateral view. The cerebral ganglion (cg) is developing and is connected to the ventral nerve cords by the circumoesophageal connectives (cc). The prototroch nerve ring now consists of multiple fibres. Serotonergic cells near the anus are connected to the ventral nerve cords by small fibres (arrow). F. Metatrochophore, ventral view. The paired ventral nerve cords gain commissures and converge posteriorly (arrowhead). Circular nerves can be seen in the periphery of each segment (arrows). Chaetae are autofluorescent. G. Juvenile, ventral view, anterior is to the top. The branchial nerves (bn) and opercular nerve net (onn) are serotonergic. A serotonergic fibre can be seen running along the intestine (arrowhead). Chaetae and uncini are autofluorescent. |
PMC1615870_F6_7467.jpg | What is the dominant medical problem in this image? | Serotonergic nervous system development in P. lamarckii. Scale bars = 50 μm. Apical is to the top of the figure in each panel unless indicated. A. Gastrula, left lateral view. One posterior cell (psc) is highly reactive for anti-serotonin. Another cell in the vicinity of the mouth is also reactive (*). Very faint, scattered fluorescent signal marks the beginning of formation of nerve fibres. B. Early trochophore, left lateral view. The posterior serotonergic cell sends processes apically. These fibres are the rudiments of the ventral nerve cords (vnc) and associate with processes that innervate the prototroch nerve ring (pnr). Fibres encircle the mouth (m). The second serotonergic cell (*) now lies posterior to the mouth and is associated with the suboesophageal ganglion.C. Early trochophore, left lateral view. The prototroch nerve ring is complete and runs behind the stomach (st). The neuropil has begun to appear in the apical organ (ao). Some gut autofluorescence is visible. D. Complete trochophore, left lateral view. A metatroch nerve ring appears (mnr). Some gut autofluorescence is visible. E. Elongating trochophore, left lateral view. The cerebral ganglion (cg) is developing and is connected to the ventral nerve cords by the circumoesophageal connectives (cc). The prototroch nerve ring now consists of multiple fibres. Serotonergic cells near the anus are connected to the ventral nerve cords by small fibres (arrow). F. Metatrochophore, ventral view. The paired ventral nerve cords gain commissures and converge posteriorly (arrowhead). Circular nerves can be seen in the periphery of each segment (arrows). Chaetae are autofluorescent. G. Juvenile, ventral view, anterior is to the top. The branchial nerves (bn) and opercular nerve net (onn) are serotonergic. A serotonergic fibre can be seen running along the intestine (arrowhead). Chaetae and uncini are autofluorescent. |
PMC1615875_F1_7473.jpg | What is the main focus of this visual representation? | Lateral Abdominal X-Ray demonstrating subcutaneous gas within the abdominal wall. |
PMC1617088_F6_7475.jpg | What is being portrayed in this visual content? | Effects of protein phosphatase 1/2A inhibition on oocyte chromatin condensation. (A) Photograph of an oocyte stained with aceto-orcein displaying the metaphase I chromatin configuration after 24 hours of IVM. (B) OA-treated oocyte (2 μM) after 24 hours of IVM displaying condensed bivalent chromatin that is scattered in the cytoplasm. Pictures were acquired on a Nikon Eclipse E600 with a Qimaging Retiga 1300 camera. The original magnification was X400. |
PMC1617088_F6_7474.jpg | What object or scene is depicted here? | Effects of protein phosphatase 1/2A inhibition on oocyte chromatin condensation. (A) Photograph of an oocyte stained with aceto-orcein displaying the metaphase I chromatin configuration after 24 hours of IVM. (B) OA-treated oocyte (2 μM) after 24 hours of IVM displaying condensed bivalent chromatin that is scattered in the cytoplasm. Pictures were acquired on a Nikon Eclipse E600 with a Qimaging Retiga 1300 camera. The original magnification was X400. |
PMC1617090_F1_7490.jpg | What key item or scene is captured in this photo? | Top panel: Computed tomography scan showing multiple rounded nodules in the right and left lung fields. Middle panel: Corresponding sections on PET scan. Bottom panel: Superimposition of PET scan on CT scan shows that the intense uptake on PET scan corresponds to the lesion in the left lower lobe on CT scan. The rest of the lesions in lung fields do not show any uptake on PET scan. |
PMC1617090_F1_7491.jpg | What's the most prominent thing you notice in this picture? | Top panel: Computed tomography scan showing multiple rounded nodules in the right and left lung fields. Middle panel: Corresponding sections on PET scan. Bottom panel: Superimposition of PET scan on CT scan shows that the intense uptake on PET scan corresponds to the lesion in the left lower lobe on CT scan. The rest of the lesions in lung fields do not show any uptake on PET scan. |
PMC1617090_F1_7492.jpg | Describe the main subject of this image. | Top panel: Computed tomography scan showing multiple rounded nodules in the right and left lung fields. Middle panel: Corresponding sections on PET scan. Bottom panel: Superimposition of PET scan on CT scan shows that the intense uptake on PET scan corresponds to the lesion in the left lower lobe on CT scan. The rest of the lesions in lung fields do not show any uptake on PET scan. |
PMC1617090_F1_7493.jpg | What stands out most in this visual? | Top panel: Computed tomography scan showing multiple rounded nodules in the right and left lung fields. Middle panel: Corresponding sections on PET scan. Bottom panel: Superimposition of PET scan on CT scan shows that the intense uptake on PET scan corresponds to the lesion in the left lower lobe on CT scan. The rest of the lesions in lung fields do not show any uptake on PET scan. |
PMC1617090_F2_7481.jpg | Can you identify the primary element in this image? | PET scan demonstrating a focus of intense FDG activity (arrow mark) in the left lung field. |
PMC1617090_F2_7483.jpg | Can you identify the primary element in this image? | PET scan demonstrating a focus of intense FDG activity (arrow mark) in the left lung field. |
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