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PMC1769361_F2_8470.jpg | What is the main focus of this visual representation? | Cyclin D1 and phospho-cyclin D1 staining patterns. (A) MRC5 cells were pulsed with BrdU and stained as described in Figure 1. Fluorescence photographs of BrdU, cyclin D1 and DNA stains for a single group of cells are presented. Separate cells stain for cyclin D1 and BrdU. (B) NIH3T3 cells were fixed and stained with antibodies against total cyclin D1, or cyclin D1 phosphorylated on Thr-286. This procedure was performed on untreated cells, or following a three hr treatment with MG132 to block proteasomal degradation. Fluorescence images of the same area of cells are presented, along with DAPI stained DNA. No accumulation of cytoplasmic cyclin D1 or phospho-cyclin D1 is apparent in any of these cells. |
PMC1769384_F2_8480.jpg | What's the most prominent thing you notice in this picture? | Spiral CT of the thorax at the level of aortopulmonary window. |
PMC1769386_F2_8485.jpg | What's the most prominent thing you notice in this picture? | Curvature Maps for the example case. Curvature maps of a manually optimised 6 beam configuration, a 5, 6, and 7 beam direction optimised configuration, and a 11 field configuration consisting of the union of the 5 BDO and 6 BDO configurations. The CM values were mapped onto a sphere for 5000 rays which sample all feasible directions of incidence. Left column: cranial view, second column: caudal view, third column: frontal view. The black excision corresponds to beam angles that were excluded due to couch/gantry collisions. Blue sectors correspond to a CM-value of zero, red and yellow regions display zones of conflicts between target objectives and normal tissue constraints. The colour scale is equivalent for all rows. Beam directions are given as red dots. |
PMC1769386_F2_8482.jpg | What is the focal point of this photograph? | Curvature Maps for the example case. Curvature maps of a manually optimised 6 beam configuration, a 5, 6, and 7 beam direction optimised configuration, and a 11 field configuration consisting of the union of the 5 BDO and 6 BDO configurations. The CM values were mapped onto a sphere for 5000 rays which sample all feasible directions of incidence. Left column: cranial view, second column: caudal view, third column: frontal view. The black excision corresponds to beam angles that were excluded due to couch/gantry collisions. Blue sectors correspond to a CM-value of zero, red and yellow regions display zones of conflicts between target objectives and normal tissue constraints. The colour scale is equivalent for all rows. Beam directions are given as red dots. |
PMC1769390_F4_8489.jpg | Describe the main subject of this image. | Synapses appear normal. (A) The ultrastructure of parallel fiber to Purkinje cell synapses was normal by electron microscopy between 2 months old control (con) and mutant (mut) animals. Parallel fibers (pf) synapse on Purkinje cell spines (s) that are fully enwrapped in Bergmann glial processes (gl). Scale bar = 500 nm. (B) Mutants performed normally on a Rotarod. The test was performed as described [27] at fixed speed levels (rpm: revolutions per minute) at the age of two and six months. The latency to fall was measured in seconds (sec) and the experiment was terminated after 60 s. The mean +/- (standard error) is shown (n>10 animals per group). |
PMC1769390_F4_8488.jpg | What is the core subject represented in this visual? | Synapses appear normal. (A) The ultrastructure of parallel fiber to Purkinje cell synapses was normal by electron microscopy between 2 months old control (con) and mutant (mut) animals. Parallel fibers (pf) synapse on Purkinje cell spines (s) that are fully enwrapped in Bergmann glial processes (gl). Scale bar = 500 nm. (B) Mutants performed normally on a Rotarod. The test was performed as described [27] at fixed speed levels (rpm: revolutions per minute) at the age of two and six months. The latency to fall was measured in seconds (sec) and the experiment was terminated after 60 s. The mean +/- (standard error) is shown (n>10 animals per group). |
PMC1769396_F2_8490.jpg | What is the main focus of this visual representation? | A. Cortical response evoked by stimulation of superficial peroneal nerve. Upper trace in the postcentral "sensory" cortex; lower trace in the precentral "motor" cortex. Time: 10 msec. B. Same as A except that stimulus was applied to posterior tibial nerve. Note that the response in the "motor" cortex is practically identical to that in the "sensory"area. |
PMC1769400_F2_8495.jpg | What is the focal point of this photograph? | Histochemical and immunohistochemical staining in muscle biopsies from AR-LGMD patients. Hematoxylin and eosin (H&E) staining (panel A), dystrophin expression (panel B), and emerin detection (panel C). |
PMC1769400_F2_8493.jpg | What is the principal component of this image? | Histochemical and immunohistochemical staining in muscle biopsies from AR-LGMD patients. Hematoxylin and eosin (H&E) staining (panel A), dystrophin expression (panel B), and emerin detection (panel C). |
PMC1769400_F2_8494.jpg | What does this image primarily show? | Histochemical and immunohistochemical staining in muscle biopsies from AR-LGMD patients. Hematoxylin and eosin (H&E) staining (panel A), dystrophin expression (panel B), and emerin detection (panel C). |
PMC1769400_F2_8498.jpg | What's the most prominent thing you notice in this picture? | Histochemical and immunohistochemical staining in muscle biopsies from AR-LGMD patients. Hematoxylin and eosin (H&E) staining (panel A), dystrophin expression (panel B), and emerin detection (panel C). |
PMC1769400_F2_8497.jpg | Can you identify the primary element in this image? | Histochemical and immunohistochemical staining in muscle biopsies from AR-LGMD patients. Hematoxylin and eosin (H&E) staining (panel A), dystrophin expression (panel B), and emerin detection (panel C). |
PMC1769400_F2_8499.jpg | What key item or scene is captured in this photo? | Histochemical and immunohistochemical staining in muscle biopsies from AR-LGMD patients. Hematoxylin and eosin (H&E) staining (panel A), dystrophin expression (panel B), and emerin detection (panel C). |
PMC1769400_F2_8500.jpg | What is the central feature of this picture? | Histochemical and immunohistochemical staining in muscle biopsies from AR-LGMD patients. Hematoxylin and eosin (H&E) staining (panel A), dystrophin expression (panel B), and emerin detection (panel C). |
PMC1769400_F2_8496.jpg | What does this image primarily show? | Histochemical and immunohistochemical staining in muscle biopsies from AR-LGMD patients. Hematoxylin and eosin (H&E) staining (panel A), dystrophin expression (panel B), and emerin detection (panel C). |
PMC1769423_pbio-0050020-g003_8503.jpg | What is the principal component of this image? | Image Processing and 3D Reconstructions of RECQ1 OligomersRepresentative images from the various stages of image-processing procedures using negatively stained untagged RECQ1 + ssDNA sample as an example.(A) Examples of individual particle images after band-pass filtering and alignment. These images are members of the corresponding class averages shown in the row below (protein is white).(B) Class averages obtained after classification.(C) Re-projections of the 3D density map in orientations corresponding to the Euler angles assigned to the class averages in the row above.(D) Surface renderings of the density map at a threshold level of σ = 3 in orientations corresponding to the Euler angles assigned to the class averages in (B). The left- and right-most images correspond to approximately diametrically opposite views of the molecule, whereas the images in-between correspond to views that are rotated by approximately 90° with respect to these, and also with respect to each other. Scale bar represents 10 nm. |
PMC1769423_pbio-0050020-g003_8501.jpg | What can you see in this picture? | Image Processing and 3D Reconstructions of RECQ1 OligomersRepresentative images from the various stages of image-processing procedures using negatively stained untagged RECQ1 + ssDNA sample as an example.(A) Examples of individual particle images after band-pass filtering and alignment. These images are members of the corresponding class averages shown in the row below (protein is white).(B) Class averages obtained after classification.(C) Re-projections of the 3D density map in orientations corresponding to the Euler angles assigned to the class averages in the row above.(D) Surface renderings of the density map at a threshold level of σ = 3 in orientations corresponding to the Euler angles assigned to the class averages in (B). The left- and right-most images correspond to approximately diametrically opposite views of the molecule, whereas the images in-between correspond to views that are rotated by approximately 90° with respect to these, and also with respect to each other. Scale bar represents 10 nm. |
PMC1769423_pbio-0050020-g003_8504.jpg | What's the most prominent thing you notice in this picture? | Image Processing and 3D Reconstructions of RECQ1 OligomersRepresentative images from the various stages of image-processing procedures using negatively stained untagged RECQ1 + ssDNA sample as an example.(A) Examples of individual particle images after band-pass filtering and alignment. These images are members of the corresponding class averages shown in the row below (protein is white).(B) Class averages obtained after classification.(C) Re-projections of the 3D density map in orientations corresponding to the Euler angles assigned to the class averages in the row above.(D) Surface renderings of the density map at a threshold level of σ = 3 in orientations corresponding to the Euler angles assigned to the class averages in (B). The left- and right-most images correspond to approximately diametrically opposite views of the molecule, whereas the images in-between correspond to views that are rotated by approximately 90° with respect to these, and also with respect to each other. Scale bar represents 10 nm. |
PMC1769423_pbio-0050020-g005_8510.jpg | What can you see in this picture? | Surface Rendering of 3D EM Reconstructions of RECQ1 OligomersUntagged wild-type RECQ1 + ssDNA (red); wild-type RECQ1+ssDNA (pink); K119R mutant RECQ1 + ATPγS (gold); and K119R mutant RECQ1 + ssDNA (white). All maps are shown using an arbitrary density threshold level of 3σ. The general shape of RECQ1 in the four functional states shows an overall similarity and consists of two ring-like densities “A” and “B,” interconnected by a larger ring-like structure “C.”(A) Side-on views showing the basic three-ring structure with the middle ring “C” connecting the two outer rings with diagonally spanning densities.(B) Head-on views of ring “A,” which has an outer diameter of 8 nm.(C) Side-on views rotated by 90° about the y-axis relative to (B).(D) Head-on views of ring “B,” which has approximately the same outer diameter as ring “A.”The resolutions of the maps range from 22 Å for the tagged RECQ1 with ssDNA reconstruction to approximately 26 Å for the untagged RECQ1 with ssDNA reconstruction. Scale bar represents 10 nm [56]. |
PMC1769497_F4_8520.jpg | What is the focal point of this photograph? | Stimulation of M2 mAChRs leads to stable co-localization of β-arrestin 2-GFP at intracellular sites. MEF wild type or KO1/2 cells were transiently co-transfected with the human FLAG-tagged M2 mAChR and β-arrestin 2-GFP constructs. Following 30 minutes of 1 mM carbachol stimulation, cells were fixed and processed for indirect immunofluorescence as described in the Methods. Localization of β-arrestin 2-GFP and M2 mAChR was visualized by confocal microscopy. Confocal images are representative of three independent experiments. |
PMC1769497_F4_8516.jpg | Describe the main subject of this image. | Stimulation of M2 mAChRs leads to stable co-localization of β-arrestin 2-GFP at intracellular sites. MEF wild type or KO1/2 cells were transiently co-transfected with the human FLAG-tagged M2 mAChR and β-arrestin 2-GFP constructs. Following 30 minutes of 1 mM carbachol stimulation, cells were fixed and processed for indirect immunofluorescence as described in the Methods. Localization of β-arrestin 2-GFP and M2 mAChR was visualized by confocal microscopy. Confocal images are representative of three independent experiments. |
PMC1769497_F4_8519.jpg | Describe the main subject of this image. | Stimulation of M2 mAChRs leads to stable co-localization of β-arrestin 2-GFP at intracellular sites. MEF wild type or KO1/2 cells were transiently co-transfected with the human FLAG-tagged M2 mAChR and β-arrestin 2-GFP constructs. Following 30 minutes of 1 mM carbachol stimulation, cells were fixed and processed for indirect immunofluorescence as described in the Methods. Localization of β-arrestin 2-GFP and M2 mAChR was visualized by confocal microscopy. Confocal images are representative of three independent experiments. |
PMC1769497_F4_8514.jpg | Can you identify the primary element in this image? | Stimulation of M2 mAChRs leads to stable co-localization of β-arrestin 2-GFP at intracellular sites. MEF wild type or KO1/2 cells were transiently co-transfected with the human FLAG-tagged M2 mAChR and β-arrestin 2-GFP constructs. Following 30 minutes of 1 mM carbachol stimulation, cells were fixed and processed for indirect immunofluorescence as described in the Methods. Localization of β-arrestin 2-GFP and M2 mAChR was visualized by confocal microscopy. Confocal images are representative of three independent experiments. |
PMC1769497_F4_8517.jpg | Describe the main subject of this image. | Stimulation of M2 mAChRs leads to stable co-localization of β-arrestin 2-GFP at intracellular sites. MEF wild type or KO1/2 cells were transiently co-transfected with the human FLAG-tagged M2 mAChR and β-arrestin 2-GFP constructs. Following 30 minutes of 1 mM carbachol stimulation, cells were fixed and processed for indirect immunofluorescence as described in the Methods. Localization of β-arrestin 2-GFP and M2 mAChR was visualized by confocal microscopy. Confocal images are representative of three independent experiments. |
PMC1769497_F7_8523.jpg | What is being portrayed in this visual content? | Addition of agonist leads to the redistribution of β-arrestin 1-GFP to early endosomal structures in the cytosol. HeLa cells were transiently transfected with human FLAG-tagged M2 mAChR and β-arrestin 1-GFP and treated with 1 mM carbachol for 30 minutes. Cells were processed for confocal microscopy. β-arrestin 1-GFP complexes localized to the early endosome as shown by colocalization with markers of that compartment (EEA-1 and TfnR). Arrows indicate signficant overlap between TfnR or EEA-1 with β-arrestin 1-GFP. Confocal images are representative of three independent experiments. |
PMC1769497_F7_8522.jpg | What key item or scene is captured in this photo? | Addition of agonist leads to the redistribution of β-arrestin 1-GFP to early endosomal structures in the cytosol. HeLa cells were transiently transfected with human FLAG-tagged M2 mAChR and β-arrestin 1-GFP and treated with 1 mM carbachol for 30 minutes. Cells were processed for confocal microscopy. β-arrestin 1-GFP complexes localized to the early endosome as shown by colocalization with markers of that compartment (EEA-1 and TfnR). Arrows indicate signficant overlap between TfnR or EEA-1 with β-arrestin 1-GFP. Confocal images are representative of three independent experiments. |
PMC1769497_F7_8521.jpg | What is shown in this image? | Addition of agonist leads to the redistribution of β-arrestin 1-GFP to early endosomal structures in the cytosol. HeLa cells were transiently transfected with human FLAG-tagged M2 mAChR and β-arrestin 1-GFP and treated with 1 mM carbachol for 30 minutes. Cells were processed for confocal microscopy. β-arrestin 1-GFP complexes localized to the early endosome as shown by colocalization with markers of that compartment (EEA-1 and TfnR). Arrows indicate signficant overlap between TfnR or EEA-1 with β-arrestin 1-GFP. Confocal images are representative of three independent experiments. |
PMC1769497_F7_8524.jpg | What's the most prominent thing you notice in this picture? | Addition of agonist leads to the redistribution of β-arrestin 1-GFP to early endosomal structures in the cytosol. HeLa cells were transiently transfected with human FLAG-tagged M2 mAChR and β-arrestin 1-GFP and treated with 1 mM carbachol for 30 minutes. Cells were processed for confocal microscopy. β-arrestin 1-GFP complexes localized to the early endosome as shown by colocalization with markers of that compartment (EEA-1 and TfnR). Arrows indicate signficant overlap between TfnR or EEA-1 with β-arrestin 1-GFP. Confocal images are representative of three independent experiments. |
PMC1769497_F7_8525.jpg | What is the main focus of this visual representation? | Addition of agonist leads to the redistribution of β-arrestin 1-GFP to early endosomal structures in the cytosol. HeLa cells were transiently transfected with human FLAG-tagged M2 mAChR and β-arrestin 1-GFP and treated with 1 mM carbachol for 30 minutes. Cells were processed for confocal microscopy. β-arrestin 1-GFP complexes localized to the early endosome as shown by colocalization with markers of that compartment (EEA-1 and TfnR). Arrows indicate signficant overlap between TfnR or EEA-1 with β-arrestin 1-GFP. Confocal images are representative of three independent experiments. |
PMC1769497_F7_8526.jpg | What is the main focus of this visual representation? | Addition of agonist leads to the redistribution of β-arrestin 1-GFP to early endosomal structures in the cytosol. HeLa cells were transiently transfected with human FLAG-tagged M2 mAChR and β-arrestin 1-GFP and treated with 1 mM carbachol for 30 minutes. Cells were processed for confocal microscopy. β-arrestin 1-GFP complexes localized to the early endosome as shown by colocalization with markers of that compartment (EEA-1 and TfnR). Arrows indicate signficant overlap between TfnR or EEA-1 with β-arrestin 1-GFP. Confocal images are representative of three independent experiments. |
PMC1769505_F3_8527.jpg | What stands out most in this visual? | Double immunostaining and immunofluorescence staining. (a) S100B (red)/GFAP (black) double immunolabelling with haematoxylin-counterstaining (blue) revealed distinct populations of cells with astrocytic morphology in the temporal cortex. White arrows indicate S100B single positive cells with astrocytic morphology; black arrows indicate GFAP immunopositive cells with astrocytic morphology. (b) Temporal brain region (overview): The majority of GFAP immunopositive (black) astrocytes were found in the glial limitans and perivascular membrane or in the adjacent white matter. Less GFAP immunopositive cells were observed in the cortex. (c) Temporal cortex and adjacent white matter (higher magnification): S100B positive (red) radial fibres and oligodendrocytes (white arrows) are shown in comparison to GFAP positive (black) astrocytes; haematoxylin-counterstaining (blue). (d) Co-localization (yellow) of S100B (red) and MBP-positive (green) myelinated fibres, extending from the temporal cortex to the adjacent white matter. (e) Co-localization (yellow) of S100B (red) and MOG-positive (green) oligodendrocytes. (f) Co-localization (yellow) of S100B (red) and A2B5-immunopositive (green) O2A glial progenitor cells in the temporal cortex. (g) No co-localization (yellow) was observed for S100B (red) and microglial HLA-DR (green). Bars: a = 100 μm; b = 500 μm; c = 30 μm. |
PMC1769505_F3_8529.jpg | Describe the main subject of this image. | Double immunostaining and immunofluorescence staining. (a) S100B (red)/GFAP (black) double immunolabelling with haematoxylin-counterstaining (blue) revealed distinct populations of cells with astrocytic morphology in the temporal cortex. White arrows indicate S100B single positive cells with astrocytic morphology; black arrows indicate GFAP immunopositive cells with astrocytic morphology. (b) Temporal brain region (overview): The majority of GFAP immunopositive (black) astrocytes were found in the glial limitans and perivascular membrane or in the adjacent white matter. Less GFAP immunopositive cells were observed in the cortex. (c) Temporal cortex and adjacent white matter (higher magnification): S100B positive (red) radial fibres and oligodendrocytes (white arrows) are shown in comparison to GFAP positive (black) astrocytes; haematoxylin-counterstaining (blue). (d) Co-localization (yellow) of S100B (red) and MBP-positive (green) myelinated fibres, extending from the temporal cortex to the adjacent white matter. (e) Co-localization (yellow) of S100B (red) and MOG-positive (green) oligodendrocytes. (f) Co-localization (yellow) of S100B (red) and A2B5-immunopositive (green) O2A glial progenitor cells in the temporal cortex. (g) No co-localization (yellow) was observed for S100B (red) and microglial HLA-DR (green). Bars: a = 100 μm; b = 500 μm; c = 30 μm. |
PMC1769505_F3_8530.jpg | What is the principal component of this image? | Double immunostaining and immunofluorescence staining. (a) S100B (red)/GFAP (black) double immunolabelling with haematoxylin-counterstaining (blue) revealed distinct populations of cells with astrocytic morphology in the temporal cortex. White arrows indicate S100B single positive cells with astrocytic morphology; black arrows indicate GFAP immunopositive cells with astrocytic morphology. (b) Temporal brain region (overview): The majority of GFAP immunopositive (black) astrocytes were found in the glial limitans and perivascular membrane or in the adjacent white matter. Less GFAP immunopositive cells were observed in the cortex. (c) Temporal cortex and adjacent white matter (higher magnification): S100B positive (red) radial fibres and oligodendrocytes (white arrows) are shown in comparison to GFAP positive (black) astrocytes; haematoxylin-counterstaining (blue). (d) Co-localization (yellow) of S100B (red) and MBP-positive (green) myelinated fibres, extending from the temporal cortex to the adjacent white matter. (e) Co-localization (yellow) of S100B (red) and MOG-positive (green) oligodendrocytes. (f) Co-localization (yellow) of S100B (red) and A2B5-immunopositive (green) O2A glial progenitor cells in the temporal cortex. (g) No co-localization (yellow) was observed for S100B (red) and microglial HLA-DR (green). Bars: a = 100 μm; b = 500 μm; c = 30 μm. |
PMC1769505_F3_8534.jpg | What is the central feature of this picture? | Double immunostaining and immunofluorescence staining. (a) S100B (red)/GFAP (black) double immunolabelling with haematoxylin-counterstaining (blue) revealed distinct populations of cells with astrocytic morphology in the temporal cortex. White arrows indicate S100B single positive cells with astrocytic morphology; black arrows indicate GFAP immunopositive cells with astrocytic morphology. (b) Temporal brain region (overview): The majority of GFAP immunopositive (black) astrocytes were found in the glial limitans and perivascular membrane or in the adjacent white matter. Less GFAP immunopositive cells were observed in the cortex. (c) Temporal cortex and adjacent white matter (higher magnification): S100B positive (red) radial fibres and oligodendrocytes (white arrows) are shown in comparison to GFAP positive (black) astrocytes; haematoxylin-counterstaining (blue). (d) Co-localization (yellow) of S100B (red) and MBP-positive (green) myelinated fibres, extending from the temporal cortex to the adjacent white matter. (e) Co-localization (yellow) of S100B (red) and MOG-positive (green) oligodendrocytes. (f) Co-localization (yellow) of S100B (red) and A2B5-immunopositive (green) O2A glial progenitor cells in the temporal cortex. (g) No co-localization (yellow) was observed for S100B (red) and microglial HLA-DR (green). Bars: a = 100 μm; b = 500 μm; c = 30 μm. |
PMC1769505_F3_8533.jpg | What is the core subject represented in this visual? | Double immunostaining and immunofluorescence staining. (a) S100B (red)/GFAP (black) double immunolabelling with haematoxylin-counterstaining (blue) revealed distinct populations of cells with astrocytic morphology in the temporal cortex. White arrows indicate S100B single positive cells with astrocytic morphology; black arrows indicate GFAP immunopositive cells with astrocytic morphology. (b) Temporal brain region (overview): The majority of GFAP immunopositive (black) astrocytes were found in the glial limitans and perivascular membrane or in the adjacent white matter. Less GFAP immunopositive cells were observed in the cortex. (c) Temporal cortex and adjacent white matter (higher magnification): S100B positive (red) radial fibres and oligodendrocytes (white arrows) are shown in comparison to GFAP positive (black) astrocytes; haematoxylin-counterstaining (blue). (d) Co-localization (yellow) of S100B (red) and MBP-positive (green) myelinated fibres, extending from the temporal cortex to the adjacent white matter. (e) Co-localization (yellow) of S100B (red) and MOG-positive (green) oligodendrocytes. (f) Co-localization (yellow) of S100B (red) and A2B5-immunopositive (green) O2A glial progenitor cells in the temporal cortex. (g) No co-localization (yellow) was observed for S100B (red) and microglial HLA-DR (green). Bars: a = 100 μm; b = 500 μm; c = 30 μm. |
PMC1769505_F3_8532.jpg | What is the core subject represented in this visual? | Double immunostaining and immunofluorescence staining. (a) S100B (red)/GFAP (black) double immunolabelling with haematoxylin-counterstaining (blue) revealed distinct populations of cells with astrocytic morphology in the temporal cortex. White arrows indicate S100B single positive cells with astrocytic morphology; black arrows indicate GFAP immunopositive cells with astrocytic morphology. (b) Temporal brain region (overview): The majority of GFAP immunopositive (black) astrocytes were found in the glial limitans and perivascular membrane or in the adjacent white matter. Less GFAP immunopositive cells were observed in the cortex. (c) Temporal cortex and adjacent white matter (higher magnification): S100B positive (red) radial fibres and oligodendrocytes (white arrows) are shown in comparison to GFAP positive (black) astrocytes; haematoxylin-counterstaining (blue). (d) Co-localization (yellow) of S100B (red) and MBP-positive (green) myelinated fibres, extending from the temporal cortex to the adjacent white matter. (e) Co-localization (yellow) of S100B (red) and MOG-positive (green) oligodendrocytes. (f) Co-localization (yellow) of S100B (red) and A2B5-immunopositive (green) O2A glial progenitor cells in the temporal cortex. (g) No co-localization (yellow) was observed for S100B (red) and microglial HLA-DR (green). Bars: a = 100 μm; b = 500 μm; c = 30 μm. |
PMC1770910_F1_8535.jpg | What is shown in this image? | CT images showing SHEAR deformity present after humeral osteotomy. Ten year old boy after unsuccessful humeral osteotomy with right-sided SHEAR deformity demonstrated in 3D CT anterior view (above) and posterior subluxation demonstrated in axial view (below). |
PMC1770914_F2_8544.jpg | What's the most prominent thing you notice in this picture? | Gray matter volume differences between groups, overlaid onto average T1 image from study. Slice numbers (relative to AC-PC origin plane) are shown in upper left corner for each slice. Relative increases (autism > control) are shown in red-orange color scale corresponding to upper right color bar and relative decreases (control > autism) are shown in blue-violet color scale corresponding to lower right color bar. The display threshold is p < .01, uncorrected, but only clusters surviving small volume correction, p < .05, are illustrated (see Table 1 for coordinates and label descriptions). |
PMC1770914_F2_8541.jpg | What is the principal component of this image? | Gray matter volume differences between groups, overlaid onto average T1 image from study. Slice numbers (relative to AC-PC origin plane) are shown in upper left corner for each slice. Relative increases (autism > control) are shown in red-orange color scale corresponding to upper right color bar and relative decreases (control > autism) are shown in blue-violet color scale corresponding to lower right color bar. The display threshold is p < .01, uncorrected, but only clusters surviving small volume correction, p < .05, are illustrated (see Table 1 for coordinates and label descriptions). |
PMC1770914_F2_8543.jpg | What object or scene is depicted here? | Gray matter volume differences between groups, overlaid onto average T1 image from study. Slice numbers (relative to AC-PC origin plane) are shown in upper left corner for each slice. Relative increases (autism > control) are shown in red-orange color scale corresponding to upper right color bar and relative decreases (control > autism) are shown in blue-violet color scale corresponding to lower right color bar. The display threshold is p < .01, uncorrected, but only clusters surviving small volume correction, p < .05, are illustrated (see Table 1 for coordinates and label descriptions). |
PMC1770914_F2_8538.jpg | What key item or scene is captured in this photo? | Gray matter volume differences between groups, overlaid onto average T1 image from study. Slice numbers (relative to AC-PC origin plane) are shown in upper left corner for each slice. Relative increases (autism > control) are shown in red-orange color scale corresponding to upper right color bar and relative decreases (control > autism) are shown in blue-violet color scale corresponding to lower right color bar. The display threshold is p < .01, uncorrected, but only clusters surviving small volume correction, p < .05, are illustrated (see Table 1 for coordinates and label descriptions). |
PMC1770914_F2_8539.jpg | What is the focal point of this photograph? | Gray matter volume differences between groups, overlaid onto average T1 image from study. Slice numbers (relative to AC-PC origin plane) are shown in upper left corner for each slice. Relative increases (autism > control) are shown in red-orange color scale corresponding to upper right color bar and relative decreases (control > autism) are shown in blue-violet color scale corresponding to lower right color bar. The display threshold is p < .01, uncorrected, but only clusters surviving small volume correction, p < .05, are illustrated (see Table 1 for coordinates and label descriptions). |
PMC1770914_F2_8545.jpg | What object or scene is depicted here? | Gray matter volume differences between groups, overlaid onto average T1 image from study. Slice numbers (relative to AC-PC origin plane) are shown in upper left corner for each slice. Relative increases (autism > control) are shown in red-orange color scale corresponding to upper right color bar and relative decreases (control > autism) are shown in blue-violet color scale corresponding to lower right color bar. The display threshold is p < .01, uncorrected, but only clusters surviving small volume correction, p < .05, are illustrated (see Table 1 for coordinates and label descriptions). |
PMC1770914_F2_8540.jpg | What key item or scene is captured in this photo? | Gray matter volume differences between groups, overlaid onto average T1 image from study. Slice numbers (relative to AC-PC origin plane) are shown in upper left corner for each slice. Relative increases (autism > control) are shown in red-orange color scale corresponding to upper right color bar and relative decreases (control > autism) are shown in blue-violet color scale corresponding to lower right color bar. The display threshold is p < .01, uncorrected, but only clusters surviving small volume correction, p < .05, are illustrated (see Table 1 for coordinates and label descriptions). |
PMC1770914_F2_8546.jpg | What is the central feature of this picture? | Gray matter volume differences between groups, overlaid onto average T1 image from study. Slice numbers (relative to AC-PC origin plane) are shown in upper left corner for each slice. Relative increases (autism > control) are shown in red-orange color scale corresponding to upper right color bar and relative decreases (control > autism) are shown in blue-violet color scale corresponding to lower right color bar. The display threshold is p < .01, uncorrected, but only clusters surviving small volume correction, p < .05, are illustrated (see Table 1 for coordinates and label descriptions). |
PMC1770923_F2_8552.jpg | What's the most prominent thing you notice in this picture? | Detailed pattern of Cre expression. (a-i) Immunohistochemical localization of Cre expression. (a) Basal ganglia, (b) prefrontal cortex, (c) cortex, (d) olfactory nucleus, (e) hippocampus, (f) septum, (g) thalamus, (h) hypothalamus and (i) retina. Abbreviations: Acb: nucleus accumbens; CA2: hippocampus CA2 field; CL: centrolateral thalamic nucleus; CM: central medial thalamic nucleus; CPu: caudate putamen; DG: dentate gyrus; GCL: ganglion cell layer; INL: inner nuclear layer; ipl: inner plexiform layer; LD: laterodorsal thalamic nucleus; ONL: outer nuclear layer; opl: outer plexiform layer. Tu: olfactory tubercle; VI: layer VI of the cortex; VMH: ventromedial hypothalamic nucleus; a-b, c-h are coronal sections; c is a sagittal section. Magnification: (a-b) 25×; (c) 5×; (d-h) 50×; (i) 100×. |
PMC1770923_F2_8548.jpg | What is the central feature of this picture? | Detailed pattern of Cre expression. (a-i) Immunohistochemical localization of Cre expression. (a) Basal ganglia, (b) prefrontal cortex, (c) cortex, (d) olfactory nucleus, (e) hippocampus, (f) septum, (g) thalamus, (h) hypothalamus and (i) retina. Abbreviations: Acb: nucleus accumbens; CA2: hippocampus CA2 field; CL: centrolateral thalamic nucleus; CM: central medial thalamic nucleus; CPu: caudate putamen; DG: dentate gyrus; GCL: ganglion cell layer; INL: inner nuclear layer; ipl: inner plexiform layer; LD: laterodorsal thalamic nucleus; ONL: outer nuclear layer; opl: outer plexiform layer. Tu: olfactory tubercle; VI: layer VI of the cortex; VMH: ventromedial hypothalamic nucleus; a-b, c-h are coronal sections; c is a sagittal section. Magnification: (a-b) 25×; (c) 5×; (d-h) 50×; (i) 100×. |
PMC1770923_F2_8547.jpg | What is the core subject represented in this visual? | Detailed pattern of Cre expression. (a-i) Immunohistochemical localization of Cre expression. (a) Basal ganglia, (b) prefrontal cortex, (c) cortex, (d) olfactory nucleus, (e) hippocampus, (f) septum, (g) thalamus, (h) hypothalamus and (i) retina. Abbreviations: Acb: nucleus accumbens; CA2: hippocampus CA2 field; CL: centrolateral thalamic nucleus; CM: central medial thalamic nucleus; CPu: caudate putamen; DG: dentate gyrus; GCL: ganglion cell layer; INL: inner nuclear layer; ipl: inner plexiform layer; LD: laterodorsal thalamic nucleus; ONL: outer nuclear layer; opl: outer plexiform layer. Tu: olfactory tubercle; VI: layer VI of the cortex; VMH: ventromedial hypothalamic nucleus; a-b, c-h are coronal sections; c is a sagittal section. Magnification: (a-b) 25×; (c) 5×; (d-h) 50×; (i) 100×. |
PMC1770923_F2_8551.jpg | What is the core subject represented in this visual? | Detailed pattern of Cre expression. (a-i) Immunohistochemical localization of Cre expression. (a) Basal ganglia, (b) prefrontal cortex, (c) cortex, (d) olfactory nucleus, (e) hippocampus, (f) septum, (g) thalamus, (h) hypothalamus and (i) retina. Abbreviations: Acb: nucleus accumbens; CA2: hippocampus CA2 field; CL: centrolateral thalamic nucleus; CM: central medial thalamic nucleus; CPu: caudate putamen; DG: dentate gyrus; GCL: ganglion cell layer; INL: inner nuclear layer; ipl: inner plexiform layer; LD: laterodorsal thalamic nucleus; ONL: outer nuclear layer; opl: outer plexiform layer. Tu: olfactory tubercle; VI: layer VI of the cortex; VMH: ventromedial hypothalamic nucleus; a-b, c-h are coronal sections; c is a sagittal section. Magnification: (a-b) 25×; (c) 5×; (d-h) 50×; (i) 100×. |
PMC1770923_F2_8554.jpg | What is the main focus of this visual representation? | Detailed pattern of Cre expression. (a-i) Immunohistochemical localization of Cre expression. (a) Basal ganglia, (b) prefrontal cortex, (c) cortex, (d) olfactory nucleus, (e) hippocampus, (f) septum, (g) thalamus, (h) hypothalamus and (i) retina. Abbreviations: Acb: nucleus accumbens; CA2: hippocampus CA2 field; CL: centrolateral thalamic nucleus; CM: central medial thalamic nucleus; CPu: caudate putamen; DG: dentate gyrus; GCL: ganglion cell layer; INL: inner nuclear layer; ipl: inner plexiform layer; LD: laterodorsal thalamic nucleus; ONL: outer nuclear layer; opl: outer plexiform layer. Tu: olfactory tubercle; VI: layer VI of the cortex; VMH: ventromedial hypothalamic nucleus; a-b, c-h are coronal sections; c is a sagittal section. Magnification: (a-b) 25×; (c) 5×; (d-h) 50×; (i) 100×. |
PMC1770923_F2_8549.jpg | What is the core subject represented in this visual? | Detailed pattern of Cre expression. (a-i) Immunohistochemical localization of Cre expression. (a) Basal ganglia, (b) prefrontal cortex, (c) cortex, (d) olfactory nucleus, (e) hippocampus, (f) septum, (g) thalamus, (h) hypothalamus and (i) retina. Abbreviations: Acb: nucleus accumbens; CA2: hippocampus CA2 field; CL: centrolateral thalamic nucleus; CM: central medial thalamic nucleus; CPu: caudate putamen; DG: dentate gyrus; GCL: ganglion cell layer; INL: inner nuclear layer; ipl: inner plexiform layer; LD: laterodorsal thalamic nucleus; ONL: outer nuclear layer; opl: outer plexiform layer. Tu: olfactory tubercle; VI: layer VI of the cortex; VMH: ventromedial hypothalamic nucleus; a-b, c-h are coronal sections; c is a sagittal section. Magnification: (a-b) 25×; (c) 5×; (d-h) 50×; (i) 100×. |
PMC1770923_F4_8569.jpg | What is the central feature of this picture? | Cre expression during embryonic development. DAPI staining on coronal sections of embryos at E14.5, E16.5 and E18.5 (a,d,g). The regions analyzed in striatum and cortex by immunohistochemistry with Cre antibody are boxed. No Cre positive cells at E14.5 are visible (b-c). At E16.5 Cre expressing cells are detected in the striatum (str) and a few scattered weakly expressing cells are observed in the cortex (cx) (e-f). At E18.5, more Cre positive cells are found in the striatum. Cre expression appeared in the cortical plate, in the presumptive layer VI (h-i). Magnification: (a,d,g) 100× (b,c,e,f,h,i) 200×. |
PMC1770923_F4_8573.jpg | What is the core subject represented in this visual? | Cre expression during embryonic development. DAPI staining on coronal sections of embryos at E14.5, E16.5 and E18.5 (a,d,g). The regions analyzed in striatum and cortex by immunohistochemistry with Cre antibody are boxed. No Cre positive cells at E14.5 are visible (b-c). At E16.5 Cre expressing cells are detected in the striatum (str) and a few scattered weakly expressing cells are observed in the cortex (cx) (e-f). At E18.5, more Cre positive cells are found in the striatum. Cre expression appeared in the cortical plate, in the presumptive layer VI (h-i). Magnification: (a,d,g) 100× (b,c,e,f,h,i) 200×. |
PMC1770923_F4_8565.jpg | What is the principal component of this image? | Cre expression during embryonic development. DAPI staining on coronal sections of embryos at E14.5, E16.5 and E18.5 (a,d,g). The regions analyzed in striatum and cortex by immunohistochemistry with Cre antibody are boxed. No Cre positive cells at E14.5 are visible (b-c). At E16.5 Cre expressing cells are detected in the striatum (str) and a few scattered weakly expressing cells are observed in the cortex (cx) (e-f). At E18.5, more Cre positive cells are found in the striatum. Cre expression appeared in the cortical plate, in the presumptive layer VI (h-i). Magnification: (a,d,g) 100× (b,c,e,f,h,i) 200×. |
PMC1770923_F4_8568.jpg | Can you identify the primary element in this image? | Cre expression during embryonic development. DAPI staining on coronal sections of embryos at E14.5, E16.5 and E18.5 (a,d,g). The regions analyzed in striatum and cortex by immunohistochemistry with Cre antibody are boxed. No Cre positive cells at E14.5 are visible (b-c). At E16.5 Cre expressing cells are detected in the striatum (str) and a few scattered weakly expressing cells are observed in the cortex (cx) (e-f). At E18.5, more Cre positive cells are found in the striatum. Cre expression appeared in the cortical plate, in the presumptive layer VI (h-i). Magnification: (a,d,g) 100× (b,c,e,f,h,i) 200×. |
PMC1770923_F4_8566.jpg | What key item or scene is captured in this photo? | Cre expression during embryonic development. DAPI staining on coronal sections of embryos at E14.5, E16.5 and E18.5 (a,d,g). The regions analyzed in striatum and cortex by immunohistochemistry with Cre antibody are boxed. No Cre positive cells at E14.5 are visible (b-c). At E16.5 Cre expressing cells are detected in the striatum (str) and a few scattered weakly expressing cells are observed in the cortex (cx) (e-f). At E18.5, more Cre positive cells are found in the striatum. Cre expression appeared in the cortical plate, in the presumptive layer VI (h-i). Magnification: (a,d,g) 100× (b,c,e,f,h,i) 200×. |
PMC1770923_F4_8572.jpg | What is the focal point of this photograph? | Cre expression during embryonic development. DAPI staining on coronal sections of embryos at E14.5, E16.5 and E18.5 (a,d,g). The regions analyzed in striatum and cortex by immunohistochemistry with Cre antibody are boxed. No Cre positive cells at E14.5 are visible (b-c). At E16.5 Cre expressing cells are detected in the striatum (str) and a few scattered weakly expressing cells are observed in the cortex (cx) (e-f). At E18.5, more Cre positive cells are found in the striatum. Cre expression appeared in the cortical plate, in the presumptive layer VI (h-i). Magnification: (a,d,g) 100× (b,c,e,f,h,i) 200×. |
PMC1770923_F5_8560.jpg | What's the most prominent thing you notice in this picture? | Cre expression during postnatal development. Immunohistochemical localization of Cre. At P0 (a-c) and P3 (d-f), striatal Cre is restricted to the patch compartment (arrowheads). Expression in layer VI of the cortex is present already at birth. Transient and very weak expression is visible in the CA1 hippocampal region (a,d,g) and in layer IV of the cortex (c,f,i). At P6 (g-i), striatal Cre expression starts in the matrix compartment (asterisk), between the patches (arrowheads). Expression in CA1 and cortex layer IV disappears progressively. Magnification: (a,b,d,e,g,h) 50×; (c,f,i) 100×. |
PMC1770923_F5_8556.jpg | What key item or scene is captured in this photo? | Cre expression during postnatal development. Immunohistochemical localization of Cre. At P0 (a-c) and P3 (d-f), striatal Cre is restricted to the patch compartment (arrowheads). Expression in layer VI of the cortex is present already at birth. Transient and very weak expression is visible in the CA1 hippocampal region (a,d,g) and in layer IV of the cortex (c,f,i). At P6 (g-i), striatal Cre expression starts in the matrix compartment (asterisk), between the patches (arrowheads). Expression in CA1 and cortex layer IV disappears progressively. Magnification: (a,b,d,e,g,h) 50×; (c,f,i) 100×. |
PMC1770923_F5_8561.jpg | What key item or scene is captured in this photo? | Cre expression during postnatal development. Immunohistochemical localization of Cre. At P0 (a-c) and P3 (d-f), striatal Cre is restricted to the patch compartment (arrowheads). Expression in layer VI of the cortex is present already at birth. Transient and very weak expression is visible in the CA1 hippocampal region (a,d,g) and in layer IV of the cortex (c,f,i). At P6 (g-i), striatal Cre expression starts in the matrix compartment (asterisk), between the patches (arrowheads). Expression in CA1 and cortex layer IV disappears progressively. Magnification: (a,b,d,e,g,h) 50×; (c,f,i) 100×. |
PMC1770923_F5_8559.jpg | Describe the main subject of this image. | Cre expression during postnatal development. Immunohistochemical localization of Cre. At P0 (a-c) and P3 (d-f), striatal Cre is restricted to the patch compartment (arrowheads). Expression in layer VI of the cortex is present already at birth. Transient and very weak expression is visible in the CA1 hippocampal region (a,d,g) and in layer IV of the cortex (c,f,i). At P6 (g-i), striatal Cre expression starts in the matrix compartment (asterisk), between the patches (arrowheads). Expression in CA1 and cortex layer IV disappears progressively. Magnification: (a,b,d,e,g,h) 50×; (c,f,i) 100×. |
PMC1770923_F5_8558.jpg | What is the core subject represented in this visual? | Cre expression during postnatal development. Immunohistochemical localization of Cre. At P0 (a-c) and P3 (d-f), striatal Cre is restricted to the patch compartment (arrowheads). Expression in layer VI of the cortex is present already at birth. Transient and very weak expression is visible in the CA1 hippocampal region (a,d,g) and in layer IV of the cortex (c,f,i). At P6 (g-i), striatal Cre expression starts in the matrix compartment (asterisk), between the patches (arrowheads). Expression in CA1 and cortex layer IV disappears progressively. Magnification: (a,b,d,e,g,h) 50×; (c,f,i) 100×. |
PMC1770923_F5_8557.jpg | What key item or scene is captured in this photo? | Cre expression during postnatal development. Immunohistochemical localization of Cre. At P0 (a-c) and P3 (d-f), striatal Cre is restricted to the patch compartment (arrowheads). Expression in layer VI of the cortex is present already at birth. Transient and very weak expression is visible in the CA1 hippocampal region (a,d,g) and in layer IV of the cortex (c,f,i). At P6 (g-i), striatal Cre expression starts in the matrix compartment (asterisk), between the patches (arrowheads). Expression in CA1 and cortex layer IV disappears progressively. Magnification: (a,b,d,e,g,h) 50×; (c,f,i) 100×. |
PMC1770923_F5_8563.jpg | What is the central feature of this picture? | Cre expression during postnatal development. Immunohistochemical localization of Cre. At P0 (a-c) and P3 (d-f), striatal Cre is restricted to the patch compartment (arrowheads). Expression in layer VI of the cortex is present already at birth. Transient and very weak expression is visible in the CA1 hippocampal region (a,d,g) and in layer IV of the cortex (c,f,i). At P6 (g-i), striatal Cre expression starts in the matrix compartment (asterisk), between the patches (arrowheads). Expression in CA1 and cortex layer IV disappears progressively. Magnification: (a,b,d,e,g,h) 50×; (c,f,i) 100×. |
PMC1770923_F5_8564.jpg | What stands out most in this visual? | Cre expression during postnatal development. Immunohistochemical localization of Cre. At P0 (a-c) and P3 (d-f), striatal Cre is restricted to the patch compartment (arrowheads). Expression in layer VI of the cortex is present already at birth. Transient and very weak expression is visible in the CA1 hippocampal region (a,d,g) and in layer IV of the cortex (c,f,i). At P6 (g-i), striatal Cre expression starts in the matrix compartment (asterisk), between the patches (arrowheads). Expression in CA1 and cortex layer IV disappears progressively. Magnification: (a,b,d,e,g,h) 50×; (c,f,i) 100×. |
PMC1770924_F3_8575.jpg | What is the main focus of this visual representation? | ETB receptor protein in (A) Ro-32-0432 RMCA, (B) control RMCA, (C) Ro-32-0432 LMCA and (D) control LMCA. There was an enhanced expression of ETB receptor protein in the smooth muscle cells in the ischemic RMCA (B). Treatment with Ro-32-0432 abolished this (A). Pictures were taken at 40× magnification. |
PMC1770924_F3_8574.jpg | What does this image primarily show? | ETB receptor protein in (A) Ro-32-0432 RMCA, (B) control RMCA, (C) Ro-32-0432 LMCA and (D) control LMCA. There was an enhanced expression of ETB receptor protein in the smooth muscle cells in the ischemic RMCA (B). Treatment with Ro-32-0432 abolished this (A). Pictures were taken at 40× magnification. |
PMC1770924_F3_8577.jpg | What's the most prominent thing you notice in this picture? | ETB receptor protein in (A) Ro-32-0432 RMCA, (B) control RMCA, (C) Ro-32-0432 LMCA and (D) control LMCA. There was an enhanced expression of ETB receptor protein in the smooth muscle cells in the ischemic RMCA (B). Treatment with Ro-32-0432 abolished this (A). Pictures were taken at 40× magnification. |
PMC1770924_F3_8576.jpg | What object or scene is depicted here? | ETB receptor protein in (A) Ro-32-0432 RMCA, (B) control RMCA, (C) Ro-32-0432 LMCA and (D) control LMCA. There was an enhanced expression of ETB receptor protein in the smooth muscle cells in the ischemic RMCA (B). Treatment with Ro-32-0432 abolished this (A). Pictures were taken at 40× magnification. |
PMC1774560_F1_8580.jpg | What is the main focus of this visual representation? | Preoperative 3D DVT-scan (digital volume tomography, New Tom 9000, New Tom Marburg, Germany), right view (left) and left view (right): initial bony situation: moderately severe atrophied mandible, severe posterior maxillary alveolar atrophy and skelettal class-III conditions due to cleft palate. |
PMC1774560_F1_8579.jpg | What is the focal point of this photograph? | Preoperative 3D DVT-scan (digital volume tomography, New Tom 9000, New Tom Marburg, Germany), right view (left) and left view (right): initial bony situation: moderately severe atrophied mandible, severe posterior maxillary alveolar atrophy and skelettal class-III conditions due to cleft palate. |
PMC1774563_F4_8582.jpg | Describe the main subject of this image. | 3D reconstruction CT scan ; Hypoplastic anterior arch of the atlas and the impacted os terminale of the odontoid (arrow) between the two halves of the maldeveloped anterior arch of the atlas-the os terminale usually fuses at 12 years of age-this can be confused with fracture. |
PMC1774563_F5_8585.jpg | What is shown in this image? | 3D sagittal CT scan; Agenesis of the posterior arch of the atlas (arrow-a). Arrow (b) notes the Wachenheim clivus line, which is drawn along the posterior aspect of the clivus toward the odontoid process; in our patient the line does not intersect or is it tangential to the odontoid process. The latter confirms the existence of progressive craniocervical abnormality. |
PMC1774563_F6_8584.jpg | What is being portrayed in this visual content? | 3D reconstruction CT scan showed agenesis of posterior arch of the atlas. |
PMC1774568_F1_8586.jpg | What object or scene is depicted here? | Magnetic resonance imaging. Axial T2-weighted sequence showing diffuse cortical atrophy predominating at the left sylvian fissure. |
PMC1774577_F1_8589.jpg | What is the principal component of this image? | Phenotype of Volvox carteri and appearance of separated cell types. A) Wild-type phenotype of an asexual female of Volvox carteri f. nagariensis containing ~2000 small, terminally differentiated somatic cells at the surface and ~16 large reproductive cells (gonidia) in the interior. More than 95% of the volume of such a spheroid consists of a complex but transparent extracellular matrix. B) Isolated somatic cell sheets of V. carteri. C) Isolated gonidia of V. carteri. |
PMC1774577_F1_8587.jpg | What is being portrayed in this visual content? | Phenotype of Volvox carteri and appearance of separated cell types. A) Wild-type phenotype of an asexual female of Volvox carteri f. nagariensis containing ~2000 small, terminally differentiated somatic cells at the surface and ~16 large reproductive cells (gonidia) in the interior. More than 95% of the volume of such a spheroid consists of a complex but transparent extracellular matrix. B) Isolated somatic cell sheets of V. carteri. C) Isolated gonidia of V. carteri. |
PMC1774577_F1_8588.jpg | What is shown in this image? | Phenotype of Volvox carteri and appearance of separated cell types. A) Wild-type phenotype of an asexual female of Volvox carteri f. nagariensis containing ~2000 small, terminally differentiated somatic cells at the surface and ~16 large reproductive cells (gonidia) in the interior. More than 95% of the volume of such a spheroid consists of a complex but transparent extracellular matrix. B) Isolated somatic cell sheets of V. carteri. C) Isolated gonidia of V. carteri. |
PMC1775063_F2_8591.jpg | What is the dominant medical problem in this image? | A drawing of the cavity of the uterus with fetus in situ by Leonardo da Vinci (15th century). In this beautiful drawing, the rim of the placenta and a coil of the umbilical cord can be seen [1]. |
PMC1775066_F6_8594.jpg | What stands out most in this visual? | Immunostaining for MMP-1, MMP-2 and MMP-3 in the pigtailed macaque endometrium. Samples were collected either on day 0 (a,c,d) or on day 2, 48 hours after P withdrawal (b,d,f). Note the strong gradient of MMP immunostaining with the strongest signal in the upper and mid functionalis zone. Magnifications (50× original magnification). |
PMC1775066_F6_8596.jpg | Can you identify the primary element in this image? | Immunostaining for MMP-1, MMP-2 and MMP-3 in the pigtailed macaque endometrium. Samples were collected either on day 0 (a,c,d) or on day 2, 48 hours after P withdrawal (b,d,f). Note the strong gradient of MMP immunostaining with the strongest signal in the upper and mid functionalis zone. Magnifications (50× original magnification). |
PMC1775066_F6_8593.jpg | What is the focal point of this photograph? | Immunostaining for MMP-1, MMP-2 and MMP-3 in the pigtailed macaque endometrium. Samples were collected either on day 0 (a,c,d) or on day 2, 48 hours after P withdrawal (b,d,f). Note the strong gradient of MMP immunostaining with the strongest signal in the upper and mid functionalis zone. Magnifications (50× original magnification). |
PMC1775066_F6_8597.jpg | Can you identify the primary element in this image? | Immunostaining for MMP-1, MMP-2 and MMP-3 in the pigtailed macaque endometrium. Samples were collected either on day 0 (a,c,d) or on day 2, 48 hours after P withdrawal (b,d,f). Note the strong gradient of MMP immunostaining with the strongest signal in the upper and mid functionalis zone. Magnifications (50× original magnification). |
PMC1775066_F6_8595.jpg | What is the principal component of this image? | Immunostaining for MMP-1, MMP-2 and MMP-3 in the pigtailed macaque endometrium. Samples were collected either on day 0 (a,c,d) or on day 2, 48 hours after P withdrawal (b,d,f). Note the strong gradient of MMP immunostaining with the strongest signal in the upper and mid functionalis zone. Magnifications (50× original magnification). |
PMC1775066_F8_8611.jpg | What key item or scene is captured in this photo? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8604.jpg | Describe the main subject of this image. | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8603.jpg | What's the most prominent thing you notice in this picture? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8607.jpg | What stands out most in this visual? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8612.jpg | What is the principal component of this image? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8605.jpg | What is the dominant medical problem in this image? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8609.jpg | What is shown in this image? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8615.jpg | What is the dominant medical problem in this image? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8610.jpg | What does this image primarily show? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8614.jpg | What is shown in this image? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8606.jpg | Describe the main subject of this image. | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8608.jpg | What stands out most in this visual? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775066_F8_8613.jpg | What is shown in this image? | Effect of P replacement on endometrial histology and MMP ICC. The photomicrographs are arranged as a grid with each treatment in columns and histological endpoints in each row. a-h: GMA sections showing endometrial histology (a-d; Magnification 100× original magnification and e-h; functionalis zone, Original Magnification 25×). i-t: ICC for MMPs. Strong staining for MMP1, MMP2, and MMP-3 was observed at 48 and 72 h in control animals. Replacement of P during, but not after, the critical period blocked menstrual breakdown (compare b to d and f to h). Replacement of P at 24 hours blocked expression of all three MMPs (j, n, r), but P replacement at 48 hours blocked MMP-1 and MMP-3 but not MMP-2 (l,p,t). |
PMC1775067_F1_8600.jpg | What is the dominant medical problem in this image? | Laparoscopic Evaluation of Lesions in a Baboon Model of Experimental Endometriosis. Visualization of the peritoneal cavity by laparoscope demonstrated the presence of powder burns (identified by a single asterisk) and blue (identified by the arrow) and chocolate lesions (identified by the double asterisks) within three (A,B) and six (C,D) months of induction of disease. |
PMC1775067_F1_8599.jpg | What stands out most in this visual? | Laparoscopic Evaluation of Lesions in a Baboon Model of Experimental Endometriosis. Visualization of the peritoneal cavity by laparoscope demonstrated the presence of powder burns (identified by a single asterisk) and blue (identified by the arrow) and chocolate lesions (identified by the double asterisks) within three (A,B) and six (C,D) months of induction of disease. |
PMC1775067_F1_8602.jpg | Can you identify the primary element in this image? | Laparoscopic Evaluation of Lesions in a Baboon Model of Experimental Endometriosis. Visualization of the peritoneal cavity by laparoscope demonstrated the presence of powder burns (identified by a single asterisk) and blue (identified by the arrow) and chocolate lesions (identified by the double asterisks) within three (A,B) and six (C,D) months of induction of disease. |
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