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PMC1785375_F1_9154.jpg | What is the principal component of this image? | GFP expression patterns driven by Promoterome reporter gene fusions. The ceh-32 Promoterome insert drives GFP expression in specific nerve cells in the head of a larva (A) and adult (B), and in anterior cells of an early embryo (C), in the C. elegans strain UL2623. An adult's anterior body wall muscle cells express GFP under the direction of the ceh-33 Promoterome insert in UL1265 (E). Additional head body wall muscle cells, as well as tail body wall muscle cells, express GFP driven by the ceh-34 Promoterome insert in larvae and adults of UL1512 (F). The unc-39 Promoterome insert drives GFP expression in specific nerve cells in an adult's head of UL2387 (G). The DIC images D and H correspond to fluorescent micrographs C and G respectively. All images were captured at 200× magnification, apart from C and D, captured at 400×, and F, captured at 100×. |
PMC1785375_F1_9152.jpg | What is the central feature of this picture? | GFP expression patterns driven by Promoterome reporter gene fusions. The ceh-32 Promoterome insert drives GFP expression in specific nerve cells in the head of a larva (A) and adult (B), and in anterior cells of an early embryo (C), in the C. elegans strain UL2623. An adult's anterior body wall muscle cells express GFP under the direction of the ceh-33 Promoterome insert in UL1265 (E). Additional head body wall muscle cells, as well as tail body wall muscle cells, express GFP driven by the ceh-34 Promoterome insert in larvae and adults of UL1512 (F). The unc-39 Promoterome insert drives GFP expression in specific nerve cells in an adult's head of UL2387 (G). The DIC images D and H correspond to fluorescent micrographs C and G respectively. All images were captured at 200× magnification, apart from C and D, captured at 400×, and F, captured at 100×. |
PMC1785375_F1_9155.jpg | What key item or scene is captured in this photo? | GFP expression patterns driven by Promoterome reporter gene fusions. The ceh-32 Promoterome insert drives GFP expression in specific nerve cells in the head of a larva (A) and adult (B), and in anterior cells of an early embryo (C), in the C. elegans strain UL2623. An adult's anterior body wall muscle cells express GFP under the direction of the ceh-33 Promoterome insert in UL1265 (E). Additional head body wall muscle cells, as well as tail body wall muscle cells, express GFP driven by the ceh-34 Promoterome insert in larvae and adults of UL1512 (F). The unc-39 Promoterome insert drives GFP expression in specific nerve cells in an adult's head of UL2387 (G). The DIC images D and H correspond to fluorescent micrographs C and G respectively. All images were captured at 200× magnification, apart from C and D, captured at 400×, and F, captured at 100×. |
PMC1785380_F1_9161.jpg | What's the most prominent thing you notice in this picture? | Cholangiographies: A and B). Endoscopic retrograde cholangiopancreatography (ERCP) and C). Magnetic resonance cholangiopancreatography (MRCP) showing a nodular mass protruding into the bile duct lumen from the left wall at the distal end of the common bile duct. |
PMC1785380_F1_9160.jpg | What is the dominant medical problem in this image? | Cholangiographies: A and B). Endoscopic retrograde cholangiopancreatography (ERCP) and C). Magnetic resonance cholangiopancreatography (MRCP) showing a nodular mass protruding into the bile duct lumen from the left wall at the distal end of the common bile duct. |
PMC1789077_pone-0000215-g003_9201.jpg | What is the core subject represented in this visual? | Mitotic activity and early appearance of high density zones (male).A,B. Mitotic activity at 52 hrs a.p. “A” shows cells visualized with anti-phospho H3 antiserum; “B” is tissue visualized using control serum (anti-ApolSNMP1, 1∶1000 dilution, after Rogers et al., 1997). Brackets mark single annuli; “d” and “p” mark distal and proximal zones. Asterisk marks discontinuous region in distal zone (see text). C,D. Mitotic figures. Tissue (67.5 hr a.p. male) was double stained with PI and anti-phospho H3 antibody (visualized with Cy2 labeled secondary antibody). Arrows point to identical cells in “C” and “D”. S E,F. High density clusters of cells along annular border as detectable by 2 hrs a.p. Images show male sensory epithelium (2 hr a.p.) centered on an annular boundary (asterisks), with high density zones evident on either side of this boundary (brackets). “E” and “F” are the same tissue at different magnification; asterisks mark identical positions as well as the annular boundary. Size bar: 350 u (A,B); 24 u (C,D).90 u (E); 45 u (F); |
PMC1789077_pone-0000215-g003_9204.jpg | What is the central feature of this picture? | Mitotic activity and early appearance of high density zones (male).A,B. Mitotic activity at 52 hrs a.p. “A” shows cells visualized with anti-phospho H3 antiserum; “B” is tissue visualized using control serum (anti-ApolSNMP1, 1∶1000 dilution, after Rogers et al., 1997). Brackets mark single annuli; “d” and “p” mark distal and proximal zones. Asterisk marks discontinuous region in distal zone (see text). C,D. Mitotic figures. Tissue (67.5 hr a.p. male) was double stained with PI and anti-phospho H3 antibody (visualized with Cy2 labeled secondary antibody). Arrows point to identical cells in “C” and “D”. S E,F. High density clusters of cells along annular border as detectable by 2 hrs a.p. Images show male sensory epithelium (2 hr a.p.) centered on an annular boundary (asterisks), with high density zones evident on either side of this boundary (brackets). “E” and “F” are the same tissue at different magnification; asterisks mark identical positions as well as the annular boundary. Size bar: 350 u (A,B); 24 u (C,D).90 u (E); 45 u (F); |
PMC1789077_pone-0000215-g003_9200.jpg | What is the dominant medical problem in this image? | Mitotic activity and early appearance of high density zones (male).A,B. Mitotic activity at 52 hrs a.p. “A” shows cells visualized with anti-phospho H3 antiserum; “B” is tissue visualized using control serum (anti-ApolSNMP1, 1∶1000 dilution, after Rogers et al., 1997). Brackets mark single annuli; “d” and “p” mark distal and proximal zones. Asterisk marks discontinuous region in distal zone (see text). C,D. Mitotic figures. Tissue (67.5 hr a.p. male) was double stained with PI and anti-phospho H3 antibody (visualized with Cy2 labeled secondary antibody). Arrows point to identical cells in “C” and “D”. S E,F. High density clusters of cells along annular border as detectable by 2 hrs a.p. Images show male sensory epithelium (2 hr a.p.) centered on an annular boundary (asterisks), with high density zones evident on either side of this boundary (brackets). “E” and “F” are the same tissue at different magnification; asterisks mark identical positions as well as the annular boundary. Size bar: 350 u (A,B); 24 u (C,D).90 u (E); 45 u (F); |
PMC1789077_pone-0000215-g003_9203.jpg | What's the most prominent thing you notice in this picture? | Mitotic activity and early appearance of high density zones (male).A,B. Mitotic activity at 52 hrs a.p. “A” shows cells visualized with anti-phospho H3 antiserum; “B” is tissue visualized using control serum (anti-ApolSNMP1, 1∶1000 dilution, after Rogers et al., 1997). Brackets mark single annuli; “d” and “p” mark distal and proximal zones. Asterisk marks discontinuous region in distal zone (see text). C,D. Mitotic figures. Tissue (67.5 hr a.p. male) was double stained with PI and anti-phospho H3 antibody (visualized with Cy2 labeled secondary antibody). Arrows point to identical cells in “C” and “D”. S E,F. High density clusters of cells along annular border as detectable by 2 hrs a.p. Images show male sensory epithelium (2 hr a.p.) centered on an annular boundary (asterisks), with high density zones evident on either side of this boundary (brackets). “E” and “F” are the same tissue at different magnification; asterisks mark identical positions as well as the annular boundary. Size bar: 350 u (A,B); 24 u (C,D).90 u (E); 45 u (F); |
PMC1789077_pone-0000215-g003_9205.jpg | What can you see in this picture? | Mitotic activity and early appearance of high density zones (male).A,B. Mitotic activity at 52 hrs a.p. “A” shows cells visualized with anti-phospho H3 antiserum; “B” is tissue visualized using control serum (anti-ApolSNMP1, 1∶1000 dilution, after Rogers et al., 1997). Brackets mark single annuli; “d” and “p” mark distal and proximal zones. Asterisk marks discontinuous region in distal zone (see text). C,D. Mitotic figures. Tissue (67.5 hr a.p. male) was double stained with PI and anti-phospho H3 antibody (visualized with Cy2 labeled secondary antibody). Arrows point to identical cells in “C” and “D”. S E,F. High density clusters of cells along annular border as detectable by 2 hrs a.p. Images show male sensory epithelium (2 hr a.p.) centered on an annular boundary (asterisks), with high density zones evident on either side of this boundary (brackets). “E” and “F” are the same tissue at different magnification; asterisks mark identical positions as well as the annular boundary. Size bar: 350 u (A,B); 24 u (C,D).90 u (E); 45 u (F); |
PMC1789077_pone-0000215-g003_9202.jpg | What can you see in this picture? | Mitotic activity and early appearance of high density zones (male).A,B. Mitotic activity at 52 hrs a.p. “A” shows cells visualized with anti-phospho H3 antiserum; “B” is tissue visualized using control serum (anti-ApolSNMP1, 1∶1000 dilution, after Rogers et al., 1997). Brackets mark single annuli; “d” and “p” mark distal and proximal zones. Asterisk marks discontinuous region in distal zone (see text). C,D. Mitotic figures. Tissue (67.5 hr a.p. male) was double stained with PI and anti-phospho H3 antibody (visualized with Cy2 labeled secondary antibody). Arrows point to identical cells in “C” and “D”. S E,F. High density clusters of cells along annular border as detectable by 2 hrs a.p. Images show male sensory epithelium (2 hr a.p.) centered on an annular boundary (asterisks), with high density zones evident on either side of this boundary (brackets). “E” and “F” are the same tissue at different magnification; asterisks mark identical positions as well as the annular boundary. Size bar: 350 u (A,B); 24 u (C,D).90 u (E); 45 u (F); |
PMC1789077_pone-0000215-g004_9182.jpg | What is the central feature of this picture? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9183.jpg | What can you see in this picture? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9170.jpg | What key item or scene is captured in this photo? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9175.jpg | What is being portrayed in this visual content? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9162.jpg | What stands out most in this visual? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9167.jpg | What is the main focus of this visual representation? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9180.jpg | What is the central feature of this picture? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9178.jpg | What is the principal component of this image? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9179.jpg | What's the most prominent thing you notice in this picture? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9176.jpg | What is shown in this image? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9172.jpg | What is the principal component of this image? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9177.jpg | What's the most prominent thing you notice in this picture? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9164.jpg | What is the central feature of this picture? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9171.jpg | What's the most prominent thing you notice in this picture? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9173.jpg | What is the principal component of this image? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9181.jpg | What object or scene is depicted here? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9163.jpg | What is being portrayed in this visual content? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g004_9168.jpg | What is being portrayed in this visual content? | Nuclear stain (PI) reveals zones of high density nuclei which expand with age.Tissues (male) of indicated ages (hours a.p.) are shown stained with PI and at three magnifications. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) of 52 hr and 67.9 hr tissues additionally point to mitotic figures. The 67.9 and 67.4 h a.p. tissues are shown in sequence of developmental progression rather than temporal progression; the differential degree of progression in these tissues is presumably due to temporal developmental asymmetry between individual animals. For all images, distal is left, proximal is to the right. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9198.jpg | Describe the main subject of this image. | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9191.jpg | What can you see in this picture? | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9195.jpg | What key item or scene is captured in this photo? | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9197.jpg | What is the focal point of this photograph? | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9196.jpg | What object or scene is depicted here? | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9188.jpg | What is the focal point of this photograph? | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9190.jpg | Describe the main subject of this image. | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9189.jpg | Describe the main subject of this image. | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9186.jpg | What can you see in this picture? | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9194.jpg | Describe the main subject of this image. | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9192.jpg | What key item or scene is captured in this photo? | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g006_9193.jpg | What does this image primarily show? | Nuclear stain (PI) reveals isolated clusters of nuclei in mid-annular regions, already present at pupation.Select tissues from the series shown in Fig. 4 are shown, focusing on mid-annular regions. Arrows mark identical positions at each magnification; brackets indicate the boundaries of a single annulus (distal is left). Arrows in high magnification panels (25 u) (4.25–52 hrs a.p.) additionally point to clusters of high density nuclei within the mid-annular regions; the high density zone has expanded into this region in the 67.4 hr tissue, obscuring the observation of these clusters. Note mitotic figures in the high magnification (25 u) 52 hr (asterisk) and 67.4 hr (arrow) panels. Size bars are shown for each row. |
PMC1789077_pone-0000215-g008_9210.jpg | What is the principal component of this image? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9220.jpg | What key item or scene is captured in this photo? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9211.jpg | Describe the main subject of this image. | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9213.jpg | What does this image primarily show? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9212.jpg | What is the central feature of this picture? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9217.jpg | What object or scene is depicted here? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9215.jpg | What is being portrayed in this visual content? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9207.jpg | What is the focal point of this photograph? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9216.jpg | What is the dominant medical problem in this image? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9214.jpg | What is the core subject represented in this visual? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9208.jpg | What is the dominant medical problem in this image? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1789077_pone-0000215-g008_9218.jpg | What stands out most in this visual? | Spatial dynamics of high density zones entering and exiting diapause.A. Presumptive sensory epithelium from animals (males); 15 hr a.p. tissue if from normal developing animal while 120 hr and 50 day a.p. tissue is from animals in diapause. Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) or days (d) a.p. Size bar (15 h–50 d): 200 u (upper), 50 u (lower). B. Presumptive sensory epithelium from animals exiting diapause, stimulated by injection of 20E at t0 (0 h). Two magnifications are shown for each tissue; arrows mark identical positions for each pair. Tissues are aged in hours (h) following hormone injection. Tissue from two animals, both aged 32h after hormone injection, are shown to note the temporal variation in response to the treatment. Size bar (0 h–32 h): 200 u (upper), 50 u (lower); Size bar (32 h*): 200 u (upper), 100 u (lower). C. Tissue exiting diapause, 20 and 32 h following hormone injection; arrows indicate mitotic figures within a high density zone. Size bar: 25 u (upper), 50 u (lower). For all figures, brackets mark single annuli. |
PMC1790702_pone-0000201-g003_9227.jpg | What is the main focus of this visual representation? | Membrane deformations on GUVs (PC/PG 9/1) induced by amphipathic peptides. Coexistence of tubes and small vesicles inside the GUVs (A, B) and adhesion of GUVs by RW9 (C). Tubes formation (D) membrane aggregates (E) and GUVs adhesion and internal vesicles (F) induced by RW16 peptide. Time-lapse sequence of a GUV burst induced by RL16, t = 0 s (G) t = 2 s (H) and t = 3 s (I). Scale bar 10 µm. |
PMC1790702_pone-0000201-g003_9221.jpg | What object or scene is depicted here? | Membrane deformations on GUVs (PC/PG 9/1) induced by amphipathic peptides. Coexistence of tubes and small vesicles inside the GUVs (A, B) and adhesion of GUVs by RW9 (C). Tubes formation (D) membrane aggregates (E) and GUVs adhesion and internal vesicles (F) induced by RW16 peptide. Time-lapse sequence of a GUV burst induced by RL16, t = 0 s (G) t = 2 s (H) and t = 3 s (I). Scale bar 10 µm. |
PMC1790702_pone-0000201-g003_9226.jpg | What can you see in this picture? | Membrane deformations on GUVs (PC/PG 9/1) induced by amphipathic peptides. Coexistence of tubes and small vesicles inside the GUVs (A, B) and adhesion of GUVs by RW9 (C). Tubes formation (D) membrane aggregates (E) and GUVs adhesion and internal vesicles (F) induced by RW16 peptide. Time-lapse sequence of a GUV burst induced by RL16, t = 0 s (G) t = 2 s (H) and t = 3 s (I). Scale bar 10 µm. |
PMC1790702_pone-0000201-g003_9222.jpg | What is the dominant medical problem in this image? | Membrane deformations on GUVs (PC/PG 9/1) induced by amphipathic peptides. Coexistence of tubes and small vesicles inside the GUVs (A, B) and adhesion of GUVs by RW9 (C). Tubes formation (D) membrane aggregates (E) and GUVs adhesion and internal vesicles (F) induced by RW16 peptide. Time-lapse sequence of a GUV burst induced by RL16, t = 0 s (G) t = 2 s (H) and t = 3 s (I). Scale bar 10 µm. |
PMC1790702_pone-0000201-g003_9228.jpg | What is the focal point of this photograph? | Membrane deformations on GUVs (PC/PG 9/1) induced by amphipathic peptides. Coexistence of tubes and small vesicles inside the GUVs (A, B) and adhesion of GUVs by RW9 (C). Tubes formation (D) membrane aggregates (E) and GUVs adhesion and internal vesicles (F) induced by RW16 peptide. Time-lapse sequence of a GUV burst induced by RL16, t = 0 s (G) t = 2 s (H) and t = 3 s (I). Scale bar 10 µm. |
PMC1790702_pone-0000201-g003_9223.jpg | What does this image primarily show? | Membrane deformations on GUVs (PC/PG 9/1) induced by amphipathic peptides. Coexistence of tubes and small vesicles inside the GUVs (A, B) and adhesion of GUVs by RW9 (C). Tubes formation (D) membrane aggregates (E) and GUVs adhesion and internal vesicles (F) induced by RW16 peptide. Time-lapse sequence of a GUV burst induced by RL16, t = 0 s (G) t = 2 s (H) and t = 3 s (I). Scale bar 10 µm. |
PMC1790702_pone-0000201-g003_9224.jpg | What is the dominant medical problem in this image? | Membrane deformations on GUVs (PC/PG 9/1) induced by amphipathic peptides. Coexistence of tubes and small vesicles inside the GUVs (A, B) and adhesion of GUVs by RW9 (C). Tubes formation (D) membrane aggregates (E) and GUVs adhesion and internal vesicles (F) induced by RW16 peptide. Time-lapse sequence of a GUV burst induced by RL16, t = 0 s (G) t = 2 s (H) and t = 3 s (I). Scale bar 10 µm. |
PMC1790702_pone-0000201-g003_9225.jpg | What is the focal point of this photograph? | Membrane deformations on GUVs (PC/PG 9/1) induced by amphipathic peptides. Coexistence of tubes and small vesicles inside the GUVs (A, B) and adhesion of GUVs by RW9 (C). Tubes formation (D) membrane aggregates (E) and GUVs adhesion and internal vesicles (F) induced by RW16 peptide. Time-lapse sequence of a GUV burst induced by RL16, t = 0 s (G) t = 2 s (H) and t = 3 s (I). Scale bar 10 µm. |
PMC1790702_pone-0000201-g003_9229.jpg | What is the core subject represented in this visual? | Membrane deformations on GUVs (PC/PG 9/1) induced by amphipathic peptides. Coexistence of tubes and small vesicles inside the GUVs (A, B) and adhesion of GUVs by RW9 (C). Tubes formation (D) membrane aggregates (E) and GUVs adhesion and internal vesicles (F) induced by RW16 peptide. Time-lapse sequence of a GUV burst induced by RL16, t = 0 s (G) t = 2 s (H) and t = 3 s (I). Scale bar 10 µm. |
PMC1790726_ppat-0030018-g005_9232.jpg | What object or scene is depicted here? | Filamentation Involves the Formation of True HyphaeFluorescent microscopy of C. elegans glp-4;sek-1 nematodes after feeding for 2 h on C. albicans strain HGFP3 transformed with pHWP1GFP3 that expresses green fluorescence in a hyphae-specific manner. Worms were transferred to Candida-free liquid media for 2 d (A–C) or 6 d (D–F). Green fluorescence is seen in hyphal cells coming out of the nematode as they penetrate the nematode cuticle. Fluorescence is shown in (B and E). (C and F) show overlap images. Scale bars are 16.16 μm (A–C) and 31.72 μm (D–F). |
PMC1790726_ppat-0030018-g005_9233.jpg | What can you see in this picture? | Filamentation Involves the Formation of True HyphaeFluorescent microscopy of C. elegans glp-4;sek-1 nematodes after feeding for 2 h on C. albicans strain HGFP3 transformed with pHWP1GFP3 that expresses green fluorescence in a hyphae-specific manner. Worms were transferred to Candida-free liquid media for 2 d (A–C) or 6 d (D–F). Green fluorescence is seen in hyphal cells coming out of the nematode as they penetrate the nematode cuticle. Fluorescence is shown in (B and E). (C and F) show overlap images. Scale bars are 16.16 μm (A–C) and 31.72 μm (D–F). |
PMC1790726_ppat-0030018-g005_9234.jpg | What object or scene is depicted here? | Filamentation Involves the Formation of True HyphaeFluorescent microscopy of C. elegans glp-4;sek-1 nematodes after feeding for 2 h on C. albicans strain HGFP3 transformed with pHWP1GFP3 that expresses green fluorescence in a hyphae-specific manner. Worms were transferred to Candida-free liquid media for 2 d (A–C) or 6 d (D–F). Green fluorescence is seen in hyphal cells coming out of the nematode as they penetrate the nematode cuticle. Fluorescence is shown in (B and E). (C and F) show overlap images. Scale bars are 16.16 μm (A–C) and 31.72 μm (D–F). |
PMC1790726_ppat-0030018-g005_9231.jpg | Describe the main subject of this image. | Filamentation Involves the Formation of True HyphaeFluorescent microscopy of C. elegans glp-4;sek-1 nematodes after feeding for 2 h on C. albicans strain HGFP3 transformed with pHWP1GFP3 that expresses green fluorescence in a hyphae-specific manner. Worms were transferred to Candida-free liquid media for 2 d (A–C) or 6 d (D–F). Green fluorescence is seen in hyphal cells coming out of the nematode as they penetrate the nematode cuticle. Fluorescence is shown in (B and E). (C and F) show overlap images. Scale bars are 16.16 μm (A–C) and 31.72 μm (D–F). |
PMC1790726_ppat-0030018-g005_9230.jpg | What can you see in this picture? | Filamentation Involves the Formation of True HyphaeFluorescent microscopy of C. elegans glp-4;sek-1 nematodes after feeding for 2 h on C. albicans strain HGFP3 transformed with pHWP1GFP3 that expresses green fluorescence in a hyphae-specific manner. Worms were transferred to Candida-free liquid media for 2 d (A–C) or 6 d (D–F). Green fluorescence is seen in hyphal cells coming out of the nematode as they penetrate the nematode cuticle. Fluorescence is shown in (B and E). (C and F) show overlap images. Scale bars are 16.16 μm (A–C) and 31.72 μm (D–F). |
PMC1790726_ppat-0030018-g005_9235.jpg | What is the central feature of this picture? | Filamentation Involves the Formation of True HyphaeFluorescent microscopy of C. elegans glp-4;sek-1 nematodes after feeding for 2 h on C. albicans strain HGFP3 transformed with pHWP1GFP3 that expresses green fluorescence in a hyphae-specific manner. Worms were transferred to Candida-free liquid media for 2 d (A–C) or 6 d (D–F). Green fluorescence is seen in hyphal cells coming out of the nematode as they penetrate the nematode cuticle. Fluorescence is shown in (B and E). (C and F) show overlap images. Scale bars are 16.16 μm (A–C) and 31.72 μm (D–F). |
PMC1790726_ppat-0030018-g007_9238.jpg | What key item or scene is captured in this photo? | Phenotypic Assay Detects Compounds with Antifungal ActivityAfter exposure to strain C. albicans MLR62, C. elegans glp-4;sek-1 nematodes were pipetted into 96-well plates that contained compounds from chemical libraries. Nematodes exposed to compounds that had antifungal efficacy (in this case, CAPE) had no fluorescence within the intestine (A), whereas nematodes exposed to compounds without antifungal efficacy did not demonstrate any movement (B) and developed filaments outside the nematodes (C). Roughly 25 worms were used per well. |
PMC1790893_F1_9241.jpg | What's the most prominent thing you notice in this picture? | A: Plain abdominal radiograph showing a PARTZ at rectosigmoid, arrow. B: Plain abdominal radiograph showing a PARTZ at midsigmoid, arrow. C: Plain abdominal radiograph showing a PARTZ at descending colon, arrow. D: Contrast enema showing a CETZ at rectosigmoid, arrow. E: Contrast enema showing a CETZ at midsigmoid, arrow. F: Contrast enema showing a CETZ at descending colon, arrow. |
PMC1790893_F1_9243.jpg | Can you identify the primary element in this image? | A: Plain abdominal radiograph showing a PARTZ at rectosigmoid, arrow. B: Plain abdominal radiograph showing a PARTZ at midsigmoid, arrow. C: Plain abdominal radiograph showing a PARTZ at descending colon, arrow. D: Contrast enema showing a CETZ at rectosigmoid, arrow. E: Contrast enema showing a CETZ at midsigmoid, arrow. F: Contrast enema showing a CETZ at descending colon, arrow. |
PMC1790893_F1_9239.jpg | What is shown in this image? | A: Plain abdominal radiograph showing a PARTZ at rectosigmoid, arrow. B: Plain abdominal radiograph showing a PARTZ at midsigmoid, arrow. C: Plain abdominal radiograph showing a PARTZ at descending colon, arrow. D: Contrast enema showing a CETZ at rectosigmoid, arrow. E: Contrast enema showing a CETZ at midsigmoid, arrow. F: Contrast enema showing a CETZ at descending colon, arrow. |
PMC1790893_F1_9244.jpg | What key item or scene is captured in this photo? | A: Plain abdominal radiograph showing a PARTZ at rectosigmoid, arrow. B: Plain abdominal radiograph showing a PARTZ at midsigmoid, arrow. C: Plain abdominal radiograph showing a PARTZ at descending colon, arrow. D: Contrast enema showing a CETZ at rectosigmoid, arrow. E: Contrast enema showing a CETZ at midsigmoid, arrow. F: Contrast enema showing a CETZ at descending colon, arrow. |
PMC1790893_F1_9240.jpg | Can you identify the primary element in this image? | A: Plain abdominal radiograph showing a PARTZ at rectosigmoid, arrow. B: Plain abdominal radiograph showing a PARTZ at midsigmoid, arrow. C: Plain abdominal radiograph showing a PARTZ at descending colon, arrow. D: Contrast enema showing a CETZ at rectosigmoid, arrow. E: Contrast enema showing a CETZ at midsigmoid, arrow. F: Contrast enema showing a CETZ at descending colon, arrow. |
PMC1790895_F3_9245.jpg | What is the principal component of this image? | A CT scan revealing recurrence at the floor of mouth and presence of tumor in the infratemporal fossa and base of skull. |
PMC1790895_F3_9246.jpg | What is the principal component of this image? | A CT scan revealing recurrence at the floor of mouth and presence of tumor in the infratemporal fossa and base of skull. |
PMC1793994_F6_9272.jpg | What is the central feature of this picture? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9263.jpg | What is the principal component of this image? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9260.jpg | What key item or scene is captured in this photo? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9266.jpg | What is the focal point of this photograph? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9277.jpg | What can you see in this picture? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9279.jpg | What key item or scene is captured in this photo? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9259.jpg | What object or scene is depicted here? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9281.jpg | What is the dominant medical problem in this image? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9261.jpg | What's the most prominent thing you notice in this picture? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9264.jpg | What is the principal component of this image? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9265.jpg | What key item or scene is captured in this photo? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9267.jpg | What is shown in this image? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F6_9276.jpg | What's the most prominent thing you notice in this picture? | Differential colocalization of GFP- and DsRed-tagged EHD proteins co-expressed in HeLa cells. HeLa cells were co-transfected with C-terminal GFP- (green) and DsRed-tagged (red) EHD proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). (A) EHD1-GFP, (B) EHD2-GFP, (C) EHD3-GFP, (D) EHD4-GFP co-transfected with each EHD-DsRed construct. Bar, 10 μm. |
PMC1793994_F7_9257.jpg | What is shown in this image? | Colocalization of EHD proteins with the endocytic recycling marker Rab11. HeLa cells were co-transfected with Rab11-GFP (green) and EHD-DsRed (red) proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). Bar, 10 μm. |
PMC1793994_F7_9247.jpg | What is being portrayed in this visual content? | Colocalization of EHD proteins with the endocytic recycling marker Rab11. HeLa cells were co-transfected with Rab11-GFP (green) and EHD-DsRed (red) proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). Bar, 10 μm. |
PMC1793994_F7_9253.jpg | What is the focal point of this photograph? | Colocalization of EHD proteins with the endocytic recycling marker Rab11. HeLa cells were co-transfected with Rab11-GFP (green) and EHD-DsRed (red) proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). Bar, 10 μm. |
PMC1793994_F7_9258.jpg | What is the core subject represented in this visual? | Colocalization of EHD proteins with the endocytic recycling marker Rab11. HeLa cells were co-transfected with Rab11-GFP (green) and EHD-DsRed (red) proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). Bar, 10 μm. |
PMC1793994_F7_9249.jpg | Can you identify the primary element in this image? | Colocalization of EHD proteins with the endocytic recycling marker Rab11. HeLa cells were co-transfected with Rab11-GFP (green) and EHD-DsRed (red) proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). Bar, 10 μm. |
PMC1793994_F7_9252.jpg | What is the dominant medical problem in this image? | Colocalization of EHD proteins with the endocytic recycling marker Rab11. HeLa cells were co-transfected with Rab11-GFP (green) and EHD-DsRed (red) proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). Bar, 10 μm. |
PMC1793994_F7_9248.jpg | What's the most prominent thing you notice in this picture? | Colocalization of EHD proteins with the endocytic recycling marker Rab11. HeLa cells were co-transfected with Rab11-GFP (green) and EHD-DsRed (red) proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). Bar, 10 μm. |
PMC1793994_F7_9256.jpg | What is being portrayed in this visual content? | Colocalization of EHD proteins with the endocytic recycling marker Rab11. HeLa cells were co-transfected with Rab11-GFP (green) and EHD-DsRed (red) proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). Bar, 10 μm. |
PMC1793994_F7_9254.jpg | What is the main focus of this visual representation? | Colocalization of EHD proteins with the endocytic recycling marker Rab11. HeLa cells were co-transfected with Rab11-GFP (green) and EHD-DsRed (red) proteins for 24 h, fixed, mounted and scanned by a confocal microscope equipped with a 100× objective lens. Colocalization is indicated when similar shaped structures appear yellow in the Merge (arrowheads). Bar, 10 μm. |
PMC1793994_F8_9288.jpg | What is the central feature of this picture? | Myc-EHD1 ΔEH and EHD3 ΔEH cause perinuclear clustering of Rab11-GFP. HeLa cells were co-transfected with Myc-EHD ΔEH proteins (red) and Rab11-GFP (green) for 24 h, fixed, stained with antibodies for Myc (9E10), mounted and scanned by a confocal microscope equipped with a 100× objective lens. |
PMC1793994_F8_9294.jpg | What is the central feature of this picture? | Myc-EHD1 ΔEH and EHD3 ΔEH cause perinuclear clustering of Rab11-GFP. HeLa cells were co-transfected with Myc-EHD ΔEH proteins (red) and Rab11-GFP (green) for 24 h, fixed, stained with antibodies for Myc (9E10), mounted and scanned by a confocal microscope equipped with a 100× objective lens. |
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