clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
Cc1cccc(C(=O)N(C)CC(O)CN(C)C(=O)c2ccc3nncn3c2)c1
CP000574007594
-25.71
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1cccc(C(=O)N(C)CCCNC(=O)c2ccc3nncn3c2)c1O
CP001962800481
-25.68
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
COC(=O)c1cccc(C(=O)NCC(O)CNC(=O)c2ccc3nncn3c2)c1
CP000320736702
-25.39
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CC(CCNC(=O)c1cccc(C(N)=O)c1)NC(=O)c1ccc2nncn2c1
CP001058662050
-25.3
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CSc1cccc(F)c1C(=O)NCCCNC(=O)c1ccc2nncn2c1
CP002330545303
-25
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1nnc2ccc(C(=O)NCC[C@H](C)NC(=O)c3ccc(CO)cc3)cn12
CP000805834261
-24.78
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CCOc1ccccc1C(=O)NC(C)CCNC(=O)c1ccc2nncn2c1
CP001057567234
-24.05
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1ccc(O)cc1C(=O)N(CCCNC(=O)c1ccc2nncn2c1)C(C)C
CP000350811297
-23.94
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1nnc2ccc(C(=O)NCC(C)CN(C)C(=O)c3ccc(N)cc3O)cn12
CP000186062864
-23.19
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1cc(O)ccc1C(=O)N(C)CCCN(C)C(=O)c1ccc2nnc(C)n2c1
CP000219899146
-23.12
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
COc1ccc(C(=O)NCCC(C)NC(=O)c2ccc3nncn3c2)c(F)c1
CP001058117950
-23.09
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1cc(C(=O)N[C@H](CCNC(=O)c2ccc3nncn3c2)C(C)C)ccc1F
CP000101417302
-22.66
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1nnc2ccc(C(=O)NCC(C)CN(C)C(=O)c3ccccc3F)cn12
CP000918402916
-22.61
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
COc1cc(C(=O)N(C)CCCN(C)C(=O)c2ccc3nncn3c2)ccc1O
CP000219899717
-21.98
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CN(CCCN(C)C(=O)c1ccc2nncn2c1)C(=O)c1ccc(F)c(N)c1
CP000952196423
-21.46
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1ccc(C(=O)NCC(O)CNC(=O)c2ccc3nncn3c2)c(N)c1C
CP001199417484
null
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CC(C)CN1CCCC1C(=O)N1CC(N(C)C(=O)c2nccc(N)c2Cl)C1
CP002167090126
-33.33
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
CN1CC(C)(C)CC1C(=O)N1CC(N(C)C(=O)c2cccc(F)n2)C1
CP003232433221
-31.73
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
Cc1ccc(C(=O)NC2CN(C(=O)C3CC(C)(C)CN3C)C2)nc1C
CP003048893798
-30.7
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
CC(C)c1cccc(C(=O)NC2(CO)CN(C(=O)C3CC(C)(C)CN3C)C2)n1
CP000846254434
-29.08
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
COC1CN(C)C(C)(C(=O)N2CC(NC(=O)c3cccc(F)n3)C2)C1
CP003047664172
-28.81
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
CCSc1cccnc1C(=O)NC1CN(C(=O)C2(C)CC(OC)CN2C)C1
CP002442207002
-26.96
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
CCCC(=O)N1CCCC1C(=O)N1CC(N(C)C(=O)c2ccc(NC)cn2)C1
CP000836516799
-26.29
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
CC(C)CN1CCCC1C(=O)N1CC(N(C)C(=O)c2cc(N)ccn2)C1
CP002769855526
-26.02
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
CCCC(=O)N1CCCC1C(=O)N1CC(NC(=O)c2ccc(NC)cn2)C1
CP002439914914
-25.73
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
CCc1cccc(C(=O)NC2(C)CN(C(=O)C3CC(C)(C)CN3C)C2)n1
CP002778209373
-24.32
O=C(NC1CN(C(=O)C2CCCN2)C1)c1ccccn1
Cc1nnsc1C(=O)N1CCCC(C(C)NC(=O)CN2CCC2)C1
CP003453059416
-54.88
O=C(CN1CCC1)NCC1CCCN(C(=O)c2cnns2)C1
O=C(NCC1CCCCN(C(=O)C2(CF)CCC2)C1)c1ccc2cn[nH]c2c1
CP000816452782
-25.49
O=C(NCC1CCCCN(C(=O)C2CCC2)C1)c1ccc2cn[nH]c2c1
CC1(C)CC(C(=O)N2CCCCC(CNC(=O)c3ccc4cn[nH]c4c3)C2)C1
CP000816452689
-25.26
O=C(NCC1CCCCN(C(=O)C2CCC2)C1)c1ccc2cn[nH]c2c1
O=C(NCC1(F)CCN(C(=O)CCc2nnc[nH]2)CC1)C1CCCC12CC2
CP001856909962
-27.1
O=C(NCC1CCN(C(=O)CCc2nnc[nH]2)CC1)C1CCCC12CC2
Cc1nnc2n1CC(C(=O)NCCC(C)NC(=O)CC1CCC(C)(C)CO1)C2
CP001060060192
-18.58
O=C(CC1CCCCO1)NCCCNC(=O)C1Cc2nncn2C1
COc1cccc(NCCC(=O)NCC2CCN2C(=O)CC2(CO)CC2)c1
CP002431226821
-22.71
O=C(CCNc1ccccc1)NCC1CCN1C(=O)CC1CC1
COC(C(=O)N1CCC1CNC(=O)CCNc1ccccc1C)C1CC1
CP002991410000
-20.8
O=C(CCNc1ccccc1)NCC1CCN1C(=O)CC1CC1
CCc1nc(CNC(=O)C2(N)CC3(CC(F)(F)C3)C2)cs1
CP002296893781
-36.54
O=C(NCc1cscn1)C1CC2(CCC2)C1
COC1CC2(C1)CC(C(=O)NCc1csc(C(C)C)n1)C2
CP002283153306
-27.06
O=C(NCc1cscn1)C1CC2(CCC2)C1
CNc1nc(CNC(=O)C2(C(=O)O)CC3(CCC3)C2)cs1
CP002276861430
-10.05
O=C(NCc1cscn1)C1CC2(CCC2)C1
CC1(C)COC1C(=O)N1CC2CC(C1)C2Nc1ccn2ccnc2n1
CP002457246206
-26.13
O=C(C1CCO1)N1CC2CC(C1)C2Nc1ccn2ccnc2n1
Cn1cnc(C(=O)NC2(CNC(=O)CNC(=O)c3ccc(N)cc3)CCCC2)n1
CP000161738271
-26.69
O=C(CNC(=O)c1ccccc1)NCC1(NC(=O)c2nc[nH]n2)CCCC1
CC(NC(=O)Cc1cn(C)nn1)C1CN(C(=O)C=CC2CC2)C1
CP003495775386
-21.59
O=C(Cc1c[nH]nn1)NCC1CN(C(=O)C=CC2CC2)C1
CC(=O)c1ccc(N2CCC(=CCNC(=O)c3cccc(F)n3)CC2)nc1
CP001405523247
-33.56
O=C(NCC=C1CCN(c2ccccn2)CC1)c1ccccn1
CN(C)c1ccnc(C(=O)NCC=C2CCN(c3ccc(C#N)cn3)CC2)c1
CP000490815081
-31.54
O=C(NCC=C1CCN(c2ccccn2)CC1)c1ccccn1
Cc1cc(C#N)cnc1N1CCC(=CCNC(=O)c2cc(O)ccn2)CC1
CP001405552439
-31.08
O=C(NCC=C1CCN(c2ccccn2)CC1)c1ccccn1
Cc1cccc(C(=O)NCC=C2CCN(c3ccc(C#N)cn3)CC2)n1
CP001729842011
-30.7
O=C(NCC=C1CCN(c2ccccn2)CC1)c1ccccn1
Cc1ccc(C#N)c(N2CCC(=CCNC(=O)c3cccc(F)n3)CC2)n1
CP001405523241
-30.54
O=C(NCC=C1CCN(c2ccccn2)CC1)c1ccccn1
N#Cc1cnc(N2CCC(=CCNC(=O)c3cc(C(N)=O)ccn3)CC2)c(F)c1
CP000129151177
-29.67
O=C(NCC=C1CCN(c2ccccn2)CC1)c1ccccn1
Cc1cc(C#N)cnc1N1CCC(=CCNC(=O)c2ccc(C(N)=O)cn2)CC1
CP000129123906
-28.19
O=C(NCC=C1CCN(c2ccccn2)CC1)c1ccccn1
COc1ccnc(C(=O)NCC=C2CCN(c3ncccc3C(C)=O)CC2)c1F
CP000129217781
-24.17
O=C(NCC=C1CCN(c2ccccn2)CC1)c1ccccn1
O=C(NCc1ncccn1)Nc1cccc(OC2CCCC2)c1
CP001553420695
-28.02
O=C(NCc1ncccn1)Nc1cccc(OC2CCCC2)c1
CC(C)C1(C(=O)NCC2C3CN(c4ncc(Br)cn4)CC23)COC1
CP002920454643
-16.76
O=C(NCC1C2CN(c3ncccn3)CC12)C1COC1
O=C(NC1C=CCN(C(=O)C2=CCSC2)C1)c1ccnnc1Cl
CP003513186562
-24.87
O=C(NC1C=CCN(C(=O)C2=CCSC2)C1)c1ccnnc1
COC(=O)c1cccnc1NC[C@H]1CCCN1C(=O)C1=COCCO1
CP002393143527
-23.44
O=C(C1=COCCO1)N1CCC[C@@H]1CNc1ccccn1
N#Cc1cc(C(=O)N[C@@H]2CCCN(C(=O)c3cccc4ccncc34)C2)co1
CP000961292280
-27.59
O=C(N[C@@H]1CCCN(C(=O)c2cccc3ccncc23)C1)c1ccoc1
Cc1ncn(C)c1C(=O)NC1CC2CCC(C1)N2Cc1nc(C(C)C)no1
CP001376493073
null
O=C(NC1CC2CCC(C1)N2Cc1ncno1)c1cnc[nH]1
Cc1noc(CCC(=O)N(C)CC2COCCN2C(=O)c2cc(O)n(C)n2)n1
CP000585715108
-27.12
O=C(CCc1ncno1)NCC1COCCN1C(=O)c1cc[nH]n1
Cc1nc(N2CC3(CCN(C(=O)c4c[nH]c(C)n4)C3)C2)c2cn[nH]c2n1
CP002216815840
-27.15
O=C(c1c[nH]cn1)N1CCC2(C1)CN(c1ncnc3[nH]ncc13)C2
CCc1[nH]c(C)nc1C(=O)N1CCC(NC(=O)C2COC(=O)O2)CC1
CP003266279017
-28.14
O=C1OCC(C(=O)NC2CCN(C(=O)c3c[nH]cn3)CC2)O1
CC1CN(C(=O)c2cn(C(C)C)cn2)CCC1NC(=O)C1COC(=O)O1
CP002822849159
-26.58
O=C1OCC(C(=O)NC2CCN(C(=O)c3c[nH]cn3)CC2)O1
Cc1nc(C(=O)N2CCC(N(C)C(=O)C3COC(=O)O3)CC2)c(C)[nH]1
CP003014226718
-21.75
O=C1OCC(C(=O)NC2CCN(C(=O)c3c[nH]cn3)CC2)O1
Cc1cc2ccc(C(=O)N[C@H]3CCCN(C(=O)C(C)C4CCCC4)C3)cn2c1
CP001138252154
-28.88
O=C(N[C@H]1CCCN(C(=O)CC2CCCC2)C1)c1ccc2cccn2c1
Cc1cnc(NC2CCN(C(=O)CCn3c(C)csc3=O)CC2)nc1C
CP001520793862
-27.89
O=C(CCn1ccsc1=O)N1CCC(Nc2ncccn2)CC1
CN(C)CCCn1cc(C2(F)CN(C(=O)c3nccnc3N)C2)nn1
CP003054569455
-42.73
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
CCOc1cnc(C(=O)N2CC(C)(c3cn(CCN(CC)CC)nn3)C2)cn1
CP001115073671
-39.64
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
CCOc1cnc(C(=O)N2CC(c3cn([C@@H](C)CO)nn3)C2)cn1
CP001906150888
-29.98
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
CN(C)c1cnc(C(=O)N2CC(c3cn(CCCCCO)nn3)C2)cn1
CP001274703665
-27.08
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
CC(C)CSCCCn1cc(C2CN(C(=O)c3cnccn3)C2)nn1
CP000393311874
-25.46
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
O=C(c1cncc(F)n1)N1CC(O)(c2cn(CCF)nn2)C1
CP003198659694
-25.03
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
CCN(CC)C(=O)Cn1cc(C2CN(C(=O)c3nc(C)c(C)nc3C)C2)nn1
CP001116564994
-25.02
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
COc1cncc(C(=O)N2CC(F)(c3cn(CCNC(=O)C(C)C)nn3)C2)n1
CP001115441909
-24.25
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
CCOC(=O)C[C@H](O)Cn1cc(C2CN(C(=O)c3cncc(Cl)n3)C2)nn1
CP001169488278
-24.21
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
CCN(CC)C(=O)Cn1cc(C2(C)CN(C(=O)c3nccnc3N)C2)nn1
CP001173925905
-22.96
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
COCCCn1cc(C2(F)CN(C(=O)c3cncc(F)n3)C2)nn1
CP001905138653
-22.79
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
Cc1nccnc1C(=O)N1CC(F)(c2cn(CCN(C)S(C)(=O)=O)nn2)C1
CP001178160830
-22.05
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
CC(O)Cn1cc(C2(C)CN(C(=O)c3nccnc3N)C2)nn1
CP001418355574
-20.89
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
COC(=O)c1nccnc1C(=O)N1CC(C)(c2cn(CCCN(C)C)nn2)C1
CP001110879768
-20.15
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
CSc1nccnc1C(=O)N1CC(C)(c2cn(CCO)nn2)C1
CP001418027075
-19.66
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
COC(=O)c1nccnc1C(=O)N1CC(C)(c2cn(CC(C)(C)O)nn2)C1
CP001178013008
-19.21
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
COCCn1cc(C2(O)CN(C(=O)c3nccnc3O)C2)nn1
CP001418645915
-17.1
O=C(c1cnccn1)N1CC(c2c[nH]nn2)C1
COc1ccc(C(=O)NC2CN(C(=O)c3ccccc3)CC23CCOCC3)nn1
CP000095682713
-22.63
O=C(NC1CN(C(=O)c2ccccc2)CC12CCOCC2)c1cccnn1
Cc1nc(C2CN(Cc3ccc(C(C)(C)C)cc3)C2)no1
CP002547019630
-41.94
c1ccc(CN2CC(c3ncon3)C2)cc1
Cc1nc(C2CN(Cc3ccccc3C(=O)N(C)C)C2)no1
CP002178507428
-31.59
c1ccc(CN2CC(c3ncon3)C2)cc1
Cc1nc(C2CN(Cc3ccc(Cl)cc3F)C2)no1
CP002859965845
-30.82
c1ccc(CN2CC(c3ncon3)C2)cc1
Cc1nc(C2CN(Cc3cc(Cl)ccc3F)C2)no1
CP002859965818
-29.93
c1ccc(CN2CC(c3ncon3)C2)cc1
CC1CC(C(=O)NCC2CCN(C(=O)C3(C)CCCCO3)CC2C)CCO1
CP001603469160
-19.35
O=C(NCC1CCN(C(=O)C2CCCCO2)CC1)C1CCOCC1
Cc1ccc(S(=O)(=O)NNC(=O)C2CCC(=O)N2)cc1F
CP002278460357
-8.36
O=C1CCC(C(=O)NNS(=O)(=O)c2ccccc2)N1
O=C1CCC(C(=O)NNS(=O)(=O)c2c(F)cccc2F)N1
CP002278460387
-4.82
O=C1CCC(C(=O)NNS(=O)(=O)c2ccccc2)N1
Cc1ccc(S(C)(=O)=O)cc1S(=O)(=O)NNC(=O)C1CCC(=O)N1
CP001338074022
-3.81
O=C1CCC(C(=O)NNS(=O)(=O)c2ccccc2)N1
COc1ccc(S(=O)(=O)NNC(=O)C2CCC(=O)N2)c(C)c1C
CP001525372128
-2.04
O=C1CCC(C(=O)NNS(=O)(=O)c2ccccc2)N1
CC(=O)c1ccc(Cl)c(S(=O)(=O)NNC(=O)C2CCC(=O)N2)c1
CP001525372160
-0.92
O=C1CCC(C(=O)NNS(=O)(=O)c2ccccc2)N1
Cc1nsc(NCc2ccc(CNC(=O)CC3(O)CCCC3)cc2)n1
CP002392979107
-38.49
O=C(CC1CCCC1)NCc1ccc(CNc2ncns2)cc1
Cc1nsc(NCc2ccc(CNC(=O)C(F)C3(O)CCCC3)cc2)n1
CP002054260277
-35.37
O=C(CC1CCCC1)NCc1ccc(CNc2ncns2)cc1
CCOc1ccc(C(=O)N2CC(NC(=O)C3C4CC5CC(C4)CC3C5)C2)cc1
CP001260868200
-28.12
O=C(NC1CN(C(=O)c2ccccc2)C1)C1C2CC3CC(C2)CC1C3
Nc1ccc(C(=O)N2CC(CO)(NC(=O)C3C4CC5CC(C4)CC3C5)C2)cc1O
CP000066470031
-24.76
O=C(NC1CN(C(=O)c2ccccc2)C1)C1C2CC3CC(C2)CC1C3
Cc1cccc(C)c1C(=O)N1CC(N(C)C(=O)C2C3CC4CC(C3)CC2C4)C1
CP000837659243
-22.1
O=C(NC1CN(C(=O)c2ccccc2)C1)C1C2CC3CC(C2)CC1C3
CC(C)C1CC(C(=O)NC2CCC3CN(C(=O)c4cnc(N)o4)CCC3C2)C1
CP000743980048
-26.37
O=C(NC1CCC2CN(C(=O)c3cnco3)CCC2C1)C1CCC1
Cc1ncc(C(=O)N2CCC3CC(NC(=O)C4(CF)CCC4)CCC3C2)o1
CP001857752625
-22.64
O=C(NC1CCC2CN(C(=O)c3cnco3)CCC2C1)C1CCC1
Cc1ncc(C(=O)N2CCC3CC(NC(=O)C4CC(C)(C)C4)CCC3C2)o1
CP001857657212
-21.87
O=C(NC1CCC2CN(C(=O)c3cnco3)CCC2C1)C1CCC1
O=C(c1cccn2ccnc12)N1CCC(N2CCN(c3nncs3)CC2)CC1
CP000427005090
-51.02
O=C(c1cccn2ccnc12)N1CCC(N2CCN(c3nncs3)CC2)CC1
CC1(NC(=O)c2ccsc2)CCN(C(=O)c2ccnc(-n3cccn3)c2)C1
CP001794167796
-24.48
O=C(NC1CCN(C(=O)c2ccnc(-n3cccn3)c2)C1)c1ccsc1
CC(CCCNC(=O)C1CCCn2ccnc21)NC(=O)CC1C(C)(C)C1(C)C
CP001085732195
-27.14
O=C(CC1CC1)NCCCCNC(=O)C1CCCn2ccnc21
CSCC1(CC(=O)NC(C)CCCNC(=O)C2CCCn3ccnc32)CC1
CP001836671849
-26.49
O=C(CC1CC1)NCCCCNC(=O)C1CCCn2ccnc21