clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
CC(C)c1c(C(=O)N2CC3(CCN(C(=O)C4=CC5CCCC45)C3)C2)cnn1C
CP001002923747
-22.83
O=C(C1=CC2CCCC12)N1CCC2(C1)CN(C(=O)c1cn[nH]c1)C2
CC1(NC(=O)c2cccc(-n3cncn3)n2)CCN(CCCC2CCOCC2)C1
CP000197076584
-32.69
O=C(NC1CCN(CCCC2CCOCC2)C1)c1cccc(-n2cncn2)n1
Nc1ncnc(N2CCCC[C@H](NC(=O)c3ccc4cnccc4n3)C2)n1
CP001450151792
-26.42
O=C(N[C@H]1CCCCN(c2ncncn2)C1)c1ccc2cnccc2n1
CN(C(=O)c1ccc2c(c1)CCC=C2)C1CN(C(=O)[C@H]2CCCO2)C1
CP003230444316
-26.48
O=C(NC1CN(C(=O)[C@H]2CCCO2)C1)c1ccc2c(c1)CCC=C2
CCOC(C(=O)N1CCC(NC(=O)c2ccc(C3(C)CCO3)cc2)C1)C1CC1
CP001240700785
-25.79
O=C(NC1CCN(C(=O)CC2CC2)C1)c1ccc(C2CCO2)cc1
Cc1cc(=O)c(C(=O)NCC2COC(CNc3nccc(CC#N)n3)C2)c[nH]1
CP000488542393
-30.42
O=C(NCC1COC(CNc2ncccn2)C1)c1c[nH]ccc1=O
Cc1cc(C(C)C)nc(NCC2CC(CNC(=O)c3cn(C)ccc3=O)CO2)n1
CP000127731761
-24.47
O=C(NCC1COC(CNc2ncccn2)C1)c1c[nH]ccc1=O
CCc1nonc1C(=O)NC[C@H](C)NC(=O)C1(C)CCC(=O)NC1
CP003442730613
-19.31
O=C1CCC(C(=O)NCCNC(=O)c2cnon2)CN1
C[C@H]1CN(C(=O)[C@@H]2CNC(=O)N2)CCN1C(=O)C1CC=CC1
CP003196048173
-23.68
O=C1NC[C@@H](C(=O)N2CCN(C(=O)C3CC=CC3)CC2)N1
Cc1ccc(C(=O)NCCC2CCN(c3nc4c(cc3C#N)CCC(C)C4)C2)o1
CP000333923209
-31.63
O=C(NCCC1CCN(c2ccc3c(n2)CCCC3)C1)c1ccco1
CCc1cc(NCC(NC(=O)c2cccn(C3CC3)c2=O)C2CC2)nc(CC)n1
CP000300654421
-33.71
O=C(NC(CNc1ccncn1)C1CC1)c1cccn(C2CC2)c1=O
O=C(NC(CNc1ccncn1)C1CC1)c1cccn(C2CC2)c1=O
CP002397744788
-25.35
O=C(NC(CNc1ccncn1)C1CC1)c1cccn(C2CC2)c1=O
CN1CCCCC(C(=O)NC[C@H]2CCN(C(=O)C=CC3CC3)C2)C1=O
CP003049472498
-24.34
O=C1NCCCCC1C(=O)NC[C@H]1CCN(C(=O)C=CC2CC2)C1
CC1CC(=O)CN(S(=O)(=O)c2ccc3c(ccn3C)c2)C1
CP001314157248
-24.03
O=C1CCCN(S(=O)(=O)c2ccc3[nH]ccc3c2)C1
C[C@@H](NC(=O)Cc1ccc(=O)[nH]c1)C1CN(C(=O)c2cn3cccnc3n2)C1
CP000791934086
-27.8
O=C(Cc1ccc(=O)[nH]c1)NCC1CN(C(=O)c2cn3cccnc3n2)C1
C[C@@H](CCNC(=O)c1cc2c(=O)[nH]ccn2n1)NC(=O)c1ccnn1C1CCC1
CP000052382504
-28.32
O=C(NCCCNC(=O)c1ccnn1C1CCC1)c1cc2c(=O)[nH]ccn2n1
CC1=NC(C(=O)N2CCC(COC3CCN(C(=O)C4(C)CC4)C3)CC2)CS1
CP001615944028
-21.66
O=C(C1CC1)N1CCC(OCC2CCN(C(=O)C3CSC=N3)CC2)C1
Cc1[nH]nc(C(=O)NC2(C)CCCN(C(=O)C(C3CC3)C3CCCO3)C2)c1C
CP000994634275
-24.98
O=C(NC1CCCN(C(=O)C(C2CC2)C2CCCO2)C1)c1cc[nH]n1
CC(F)(F)C1(NC(=O)Nc2ccn(C3CCNC3=O)n2)CC1
CP002175480911
-25.61
O=C(Nc1ccn(C2CCNC2=O)n1)NC1CC1
CC(C(=O)N(C)C1CN(C(=O)C(O)C2CCCCCC2)C1)c1ccc(C#N)cc1
CP000183908287
-31.35
O=C(Cc1ccccc1)NC1CN(C(=O)CC2CCCCCC2)C1
CC(=O)NC(C(=O)NC1CN(C(=O)CC2CCCCCC2)C1)c1ccccc1
CP001262383824
-26.73
O=C(Cc1ccccc1)NC1CN(C(=O)CC2CCCCCC2)C1
Nc1cccc(CC(=O)NC2CN(C(=O)C(O)C3CCCCCC3)C2)c1
CP003003823132
-24.7
O=C(Cc1ccccc1)NC1CN(C(=O)CC2CCCCCC2)C1
CC1(NC(=O)Cc2c(F)cccc2F)CN(C(=O)CC2CCCCCC2)C1
CP002028539054
-23.68
O=C(Cc1ccccc1)NC1CN(C(=O)CC2CCCCCC2)C1
CC(O)(C(=O)NC1CN(C(=O)C(O)C2CCCCCC2)C1)c1ccc(F)cc1
CP001263927952
-20.31
O=C(Cc1ccccc1)NC1CN(C(=O)CC2CCCCCC2)C1
CNC(=O)c1cc(C)nc(NCc2ccccc2N2CCOCC2)n1
CP000398050090
-26.22
c1cnc(NCc2ccccc2N2CCOCC2)nc1
CC1=NOC(C(=O)NC2CN(C(=O)C3(C)CC(C4CC4)=NO3)C2)C1
CP001899915716
-21.22
O=C(NC1CN(C(=O)C2CC(C3CC3)=NO2)C1)C1CC=NO1
C=CCC1(C(=O)N2CCC(CCNC(=O)c3ncnn3C(C)C)C2)CC=CC1
CP001100298967
-23
O=C(NCCC1CCN(C(=O)C2CC=CC2)C1)c1ncn[nH]1
O=C(NCCNc1ncnc2c1CCC2)C1CCCC2CC21
CP003468193619
-29.05
O=C(NCCNc1ncnc2c1CCC2)C1CCCC2CC21
Cc1cccc(CC(=O)N2CC(CNC(=O)C#CC3CCC(=O)CC3)C2)c1
CP002448839676
-28.45
O=C1CCC(C#CC(=O)NCC2CN(C(=O)Cc3ccccc3)C2)CC1
CCn1cnnc1C(=O)N1CCC[C@H](CNC(=O)CN(C)c2ccccc2)C1
CP000839981285
-27.82
O=C(CNc1ccccc1)NC[C@H]1CCCN(C(=O)c2nnc[nH]2)C1
CCC1(C(=O)NC2CC3(CCN(C(=O)C4CC5(CCC5)CO4)CC3)C2)CC1
CP002026708904
-19.62
O=C(NC1CC2(CCN(C(=O)C3CC4(CCC4)CO3)CC2)C1)C1CC1
Cc1cc(C)nc(C(=O)NCC2C3CN(c4cc(-n5ccnc5)ncn4)CC23)c1
CP000234927678
-31.91
O=C(NCC1C2CN(c3cc(-n4ccnc4)ncn3)CC12)c1ccccn1
Cc1ccnc(C(=O)NCC2C3CN(c4cc(-n5ccnc5)ncn4)CC23)c1
CP000415911045
-30.66
O=C(NCC1C2CN(c3cc(-n4ccnc4)ncn3)CC12)c1ccccn1
Cn1ccc(CCC(=O)NCC2CN(c3nncs3)CCCO2)n1
CP002922231877
-22.62
O=C(CCc1cc[nH]n1)NCC1CN(c2nncs2)CCCO1
Nc1ccnc(C(=O)N[C@H]2C[C@@H](CNC(=O)c3ccc(Cn4ccnn4)o3)C2)c1
CP000110459831
-25.19
O=C(N[C@H]1C[C@@H](CNC(=O)c2ccc(Cn3ccnn3)o2)C1)c1ccccn1
CCN1CCC1C(=O)N(C)C1CN(C(=O)Cn2nc3c(n2)CCCC3)C1
CP002771199403
-37.92
O=C(NC1CN(C(=O)Cn2nc3c(n2)CCCC3)C1)C1CCN1
CC1=C(C(=O)N2CC([C@@H](C)NC(=O)CC3COCCO3)C2)CCC1
CP003393046358
-23.5
O=C(CC1COCCO1)NCC1CN(C(=O)C2=CCCC2)C1
Cc1cc(C)c(C(=O)NCC(NC(=O)CCc2cscn2)C(C)C)c(=O)o1
CP002091414620
-26.29
O=C(CCc1cscn1)NCCNC(=O)c1cccoc1=O
COC(C(=O)N1CCC(CCNC(=O)c2ccc3c(c2)NCC3)C1)C1CCCC1
CP000267373886
-29.62
O=C(NCCC1CCN(C(=O)CC2CCCC2)C1)c1ccc2c(c1)NCC2
CC1CCN(C(=O)C2CCCOC2)CC1CNC(=O)c1ccnc2ccccc12
CP000081485306
-27.76
O=C(NCC1CCCN(C(=O)C2CCCOC2)C1)c1ccnc2ccccc12
O=C(NCCN1CCN(Cc2cn(-c3ccccc3)nn2)CC1)c1cocn1
CP000497635780
-33.29
O=C(NCCN1CCN(Cc2cn(-c3ccccc3)nn2)CC1)c1cocn1
CNC(=O)c1ccc(C(=O)N2CC3CCCC(C2)N3Cc2ncccc2C)cn1
CP000196525902
-29.75
O=C(c1cccnc1)N1CC2CCCC(C1)N2Cc1ccccn1
COc1cccc(CN2C3CCCC2CN(C(=O)c2cccnc2N(C)C)C3)n1
CP000196511756
-24.28
O=C(c1cccnc1)N1CC2CCCC(C1)N2Cc1ccccn1
O=C(c1ccccc1-n1cccc1)N1CCN2C(=O)OCC2C1
CP001544643644
-23.9
O=C(c1ccccc1-n1cccc1)N1CCN2C(=O)OCC2C1
Cn1cnc(NCC2CCCCN2C(=O)C#CC2(C)CCCO2)cc1=O
CP002044471975
-21.4
O=C(C#CC1CCCO1)N1CCCCC1CNc1cc(=O)[nH]cn1
CC1(C(=O)N2CC3CC(C2)N(C(=O)CC2COC(=O)C2)C3)CCCCC1
CP002519468316
null
O=C1CC(CC(=O)N2CC3CC2CN(C(=O)C2CCCCC2)C3)CO1
O=C1CCCCC(C(=O)NC2CC(CNC(=O)c3n[nH]c4c3CCC4)C2)C1
CP002320430854
-34.18
O=C1CCCCC(C(=O)NC2CC(CNC(=O)c3n[nH]c4c3CCC4)C2)C1
CN(CCOCCNC(=O)c1cnccc1O)C(=O)c1cccc2ncn(C)c12
CP000100966616
-33.21
O=C(NCCOCCNC(=O)c1cccc2nc[nH]c12)c1cccnc1
CN(CCOCCNC(=O)c1cccc2ncn(C)c12)C(=O)c1cncc(N)c1
CP000100804537
-25.2
O=C(NCCOCCNC(=O)c1cccc2nc[nH]c12)c1cccnc1
CCc1cc(NC2CCN(C(=O)C3CCCCCC3)CC2C)nc(C)n1
CP002056246695
-43.95
O=C(C1CCCCCC1)N1CCC(Nc2ccncn2)CC1
Cc1ncnc(NC2CCN(C(=O)C3CCCC(F)(F)CC3)CC2)c1F
CP001521031076
-36.05
O=C(C1CCCCCC1)N1CCC(Nc2ccncn2)CC1
CN(c1cc(Cl)ncn1)C1CCN(C(=O)C2(O)CCCCCC2)CC1
CP002452892548
-24.68
O=C(C1CCCCCC1)N1CCC(Nc2ccncn2)CC1
CCc1ncnc(N(C)C2CCN(C(=O)C3CCCC(F)(F)CC3)CC2)c1F
CP000438866217
-24.62
O=C(C1CCCCCC1)N1CCC(Nc2ccncn2)CC1
COc1cc(NC2CCN(C(=O)C3CCCC(F)(F)CC3)CC2)ncn1
CP001521031094
-24.02
O=C(C1CCCCCC1)N1CCC(Nc2ccncn2)CC1
CCOc1cc(NC2CCN(C(=O)C3(O)CCCCCC3)CC2C)nc(C)n1
CP000462845210
-23.85
O=C(C1CCCCCC1)N1CCC(Nc2ccncn2)CC1
COCc1nc(O)cc(NC2CCN(C(=O)C3(O)CCCC(C)CC3)CC2)n1
CP000483367942
-15.23
O=C(C1CCCCCC1)N1CCC(Nc2ccncn2)CC1
O=C(C1CCCCO1)N1CCOC2(C1)CN(C(=O)C1(Cc3ccccc3)CC1)C2
CP000220602104
-27.03
O=C(C1CCCCO1)N1CCOC2(C1)CN(C(=O)C1(Cc3ccccc3)CC1)C2
O=C(NCC1CCCC1NC(=O)c1cccc2ccsc12)c1ccccn1
CP002095758437
-29.49
O=C(NCC1CCCC1NC(=O)c1cccc2ccsc12)c1ccccn1
O=C(C1CCCC1)N1CCO[C@]2(CC[C@H](NC(=O)C3(F)CCCCC3)CC2)C1
CP000751424345
-23.74
O=C(N[C@H]1CC[C@]2(CC1)CN(C(=O)C1CCCC1)CCO2)C1CCCCC1
O=C(NC(CNC(=O)C1CCCCC1C1CC1)C1CCCC1)C1CCC=CO1
CP000697088699
-26.52
O=C(NC(CNC(=O)C1CCCCC1C1CC1)C1CCCC1)C1CCC=CO1
CC(C)c1nc(C(=O)N2CCCC2CCCNC(=O)C2=CCCOCC2)c[nH]1
CP001061129436
-27.96
O=C(NCCCC1CCCN1C(=O)c1c[nH]cn1)C1=CCCOCC1
O=C1OCc2ccc(NCc3c(Cl)cccc3N3CCOCC3)cc21
CP001164559804
-26.52
O=C1OCc2ccc(NCc3ccccc3N3CCOCC3)cc21
CN(C)CCC1CCN(C(=O)C(=O)Nc2ccc(C(=O)NC3CC3)cc2)CC1
CP000411139750
-52.62
O=C(Nc1ccc(C(=O)NC2CC2)cc1)C(=O)N1CCCCC1
CC1(C)CCCN(C(=O)C(=O)Nc2ccc(C(=O)NC3CC3)cc2)C1
CP001569004866
-37.79
O=C(Nc1ccc(C(=O)NC2CC2)cc1)C(=O)N1CCCCC1
CC1(CN)CCN(C(=O)C(=O)Nc2ccc(C(=O)NC3CC3)cc2)CC1
CP001516573329
-37.66
O=C(Nc1ccc(C(=O)NC2CC2)cc1)C(=O)N1CCCCC1
O=C(Nc1ccc(C(=O)NC2CC2)cc1)C(=O)N1CCCC(O)(C(F)F)C1
CP001284932971
-30.9
O=C(Nc1ccc(C(=O)NC2CC2)cc1)C(=O)N1CCCCC1
CNc1cncc(C(=O)NC2CCC(NC(=O)C(C)(C)n3cnnn3)CC2)c1
CP001236113557
-23.17
O=C(Cn1cnnn1)NC1CCC(NC(=O)c2cccnc2)CC1
Cc1ccncc1C(=O)N(C)C1CCC(NC(=O)Cn2nnnc2C)CC1
CP001981400767
-22.73
O=C(Cn1cnnn1)NC1CCC(NC(=O)c2cccnc2)CC1
C=C1CC(C)(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)COC2CCCCC2)C1
CP003154326267
-22.13
C=C1CC(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)COC2CCCCC2)C1
CC1CN(C(=O)C2CC(C3CCOCC3)=NO2)CCN1C(=O)Cn1cnnn1
CP000677797144
-21.48
O=C(Cn1cnnn1)N1CCN(C(=O)C2CC(C3CCOCC3)=NO2)CC1
C[C@@H](CCNC(=O)c1cc(F)cc2ccncc12)NC(=O)c1cccn(C)c1=O
CP000052267319
-25.56
O=C(NCCCNC(=O)c1cccc2ccncc12)c1ccc[nH]c1=O
CC1(NC(=O)Cn2cc(CO)nn2)CN(C(=O)C23CC2C3)C1
CP003189285020
-17.42
O=C(Cn1ccnn1)NC1CN(C(=O)C23CC2C3)C1
O=C(C=CC1CC1)NCCCOCCNC(=O)C1CCOC2(CCC2)C1
CP002528164152
-13.95
O=C(C=CC1CC1)NCCCOCCNC(=O)C1CCOC2(CCC2)C1
CCN1C(=O)CCC1C(=O)NCC1CN(C(=O)C(C)N2CCC2)CCC1(C)C
CP000820848483
-27.5
O=C1CCC(C(=O)NCC2CCCN(C(=O)CN3CCC3)C2)N1
CC[C@H]1CC[C@H](C(=O)N[C@@H]2CCN(Cc3csnn3)C2)CC1
CP003477072208
-29.07
O=C(N[C@@H]1CCN(Cc2csnn2)C1)C1CCCCC1
CC1CCCCC1C(=O)N[C@@H]1CCN(Cc2nnsc2Cl)C1
CP003477104787
-27.63
O=C(N[C@@H]1CCN(Cc2csnn2)C1)C1CCCCC1
C=CCC1(C(=O)N[C@@H]2CCN(Cc3nnsc3Cl)C2)CCCCC1
CP003130262231
-25.1
O=C(N[C@@H]1CCN(Cc2csnn2)C1)C1CCCCC1
Cc1csc(CN2C3CCC2CC(NC(=O)c2ccc(F)c(C)c2)C3)n1
CP001736537714
-29.57
O=C(NC1CC2CCC(C1)N2Cc1nccs1)c1ccccc1
CCc1c(C(=O)NCC(C)CNC(=O)CC2C=CCC2)ccn1C
CP003432812922
-27.78
O=C(CC1C=CCC1)NCCCNC(=O)c1cc[nH]c1
Cc1c[nH]cc1C(=O)N(C)CC(O)CN(C)C(=O)CC1C=CCC1
CP003376258645
-23.01
O=C(CC1C=CCC1)NCCCNC(=O)c1cc[nH]c1
Cc1c[nH]cc1C(=O)N(C)CC(C)CNC(=O)CC1C=CCC1
CP003504419954
-22.61
O=C(CC1C=CCC1)NCCCNC(=O)c1cc[nH]c1
Cc1cc(C(=O)N(C)C(C)CCNC(=O)CC2C=CCC2)c[nH]1
CP003514897305
-21.39
O=C(CC1C=CCC1)NCCCNC(=O)c1cc[nH]c1
Cc1cc(N2CC=CC(NC(=O)c3cc4ccccn4c3)C2)nc(C2CC2)n1
CP000435523614
-41.27
O=C(NC1C=CCN(c2ccnc(C3CC3)n2)C1)c1cc2ccccn2c1
CC(CNC(=O)c1ccn2ccnc2c1)NC(=O)c1ccc(-n2cccn2)cc1
CP000363974746
-33.33
O=C(NCCNC(=O)c1ccn2ccnc2c1)c1ccc(-n2cccn2)cc1
CC1=CCC(C(=O)NCC(C)CNC(=O)c2cnc(CC3CC3)[nH]c2=O)CC1
CP001032583664
-31.14
O=C(NCCCNC(=O)C1CC=CCC1)c1cnc(CC2CC2)[nH]c1=O
CC1CN(C(=O)Cc2ccc(Cl)s2)CC(C)N(C(=O)[C@@H]2CNC(=O)N2)C1
CP002514060673
-26.28
O=C1NC[C@@H](C(=O)N2CCCN(C(=O)Cc3cccs3)CC2)N1
O=C(O)C(CNCc1cnn(C2CCCCC2)c1)Cc1cccnc1
CP001566281712
-22.67
c1cncc(CCCNCc2cnn(C3CCCCC3)c2)c1
COC12CCC(c3cn(C4CN(C(=O)C5C(F)(F)C56CCC6)C4)nn3)(CC1)C2
CP001114764911
-23.02
O=C(C1CC12CCC2)N1CC(n2cc(C34CCC(CC3)C4)nn2)C1
CC(=O)NC1CCN(C(=O)c2cn(CC3CN(C(=O)OC(C)(C)C)C3)nn2)C1
CP000386019874
-22.68
O=C(c1cn(CC2CNC2)nn1)N1CCCC1
C[C@H](NC(=O)Cn1nnc2c1CCCC2)C1CCN(C2CCNC2=O)CC1
CP001585334522
-31.21
O=C(Cn1nnc2c1CCCC2)NCC1CCN(C2CCNC2=O)CC1
CCCn1ccc(C(=O)NCCCCCCN(C)C(=O)Cc2cnns2)n1
CP001614089785
-26.72
O=C(Cc1cnns1)NCCCCCCNC(=O)c1cc[nH]n1
Cn1cccc1CC(=O)NCCC1CCN(C(=O)C2(C(F)F)CC2)C1
CP003085632512
-22.34
O=C(Cc1ccc[nH]1)NCCC1CCN(C(=O)C2CC2)C1
O=C(NCCCN(C(=O)c1csc(Cl)c1)C1CC1)C1CC12CCC2
CP003445912308
-26.38
O=C(NCCCN(C(=O)c1ccsc1)C1CC1)C1CC12CCC2
CC1CCCN(C(=O)C2CC3(CC(O)C3)C2)C1CCNC(=O)C=CC1CC1
CP001611902186
-21.41
O=C(C=CC1CC1)NCCC1CCCCN1C(=O)C1CC2(CCC2)C1
CCCN(CCNC(=O)c1cn(CC2CC2)nn1)C(=O)c1cnccn1
CP002885907597
-26.69
O=C(NCCNC(=O)c1cn(CC2CC2)nn1)c1cnccn1
CSc1nccnc1C(=O)N(C)CC(C)NC(=O)c1cn(CC2CC2)nn1
CP002192868927
-23.63
O=C(NCCNC(=O)c1cn(CC2CC2)nn1)c1cnccn1
CC(C)Oc1cnc(C(=O)NC[C@H](C)NC(=O)c2cn(CC3CC3)nn2)cn1
CP001203474750
-21.37
O=C(NCCNC(=O)c1cn(CC2CC2)nn1)c1cnccn1
CC(c1cnccn1)c1noc(-c2cc(=O)c3ccc(Cl)cc3o2)n1
CP001165858789
-32.62
O=c1cc(-c2nc(Cc3cnccn3)no2)oc2ccccc12
Cn1nnnc1N1CCC2(CC1)CN(C(=O)c1ccc3c(c1)COC3)CCO2
CP000413131056
-18.95
O=C(c1ccc2c(c1)COC2)N1CCOC2(CCN(c3nnn[nH]3)CC2)C1
CN(CCN(C)C(=O)c1cccc2cc(F)ccc12)C(=O)COC1CCOC1
CP000692895509
-18.56
O=C(COC1CCOC1)NCCNC(=O)c1cccc2ccccc12