clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
Cc1c(C(=O)N2CCC2C2CCOCC2)cc(CNC(=O)OC(C)(C)C)n1C
CP000388030155
-27.29
O=C(c1cc[nH]c1)N1CCC1C1CCOCC1
Cc1noc(C)c1CNC(=O)c1nc2ccccc2cc1Br
CP001679145986
-28.62
O=C(NCc1cnoc1)c1ccc2ccccc2n1
O=C(CC(O)C1CC1)NCC1(NC(=O)C2=Cc3cc(F)ccc3OC2)CC1
CP002203767392
-26.4
O=C(CCC1CC1)NCC1(NC(=O)C2=Cc3ccccc3OC2)CC1
Cn1nc(C(C)(C)C)cc1C(=O)N1CC2(CN(C(=O)c3c[nH]c(=O)cn3)C2)C1
CP000853437191
-28.08
O=C(c1c[nH]c(=O)cn1)N1CC2(C1)CN(C(=O)c1ccn[nH]1)C2
Cn1nccc1C(=O)N1CCC(C2(NC(=O)C3(C4CCCO4)CC3)CC2)CC1
CP000934990673
-19.21
O=C(c1ccn[nH]1)N1CCC(C2(NC(=O)C3(C4CCCO4)CC3)CC2)CC1
CN(CCCNC(=O)[C@@H]1CC=CCC1)C(=O)C1CC2(C1)CC1(CCC1)C2
CP002737028506
-31.45
O=C(NCCCNC(=O)[C@@H]1CC=CCC1)C1CC2(C1)CC1(CCC1)C2
CCOc1cc(C(=O)NCc2cc(=O)[nH][nH]2)ccc1OCc1cccnc1
CP000535259522
-28.56
O=C(NCc1cc(=O)[nH][nH]1)c1ccc(OCc2cccnc2)cc1
CC(C)c1noc(CCC(=O)N2CCN(C(=O)C3(C)COC3)CC(O)C2)n1
CP002031539895
-18.01
O=C(CCc1ncno1)N1CCCN(C(=O)C2COC2)CC1
N#Cc1nnn(Cc2ccccc2)c1NC(=O)C12CC3CC(CC(F)(C3)C1)C2
CP000383465729
-26.45
O=C(Nc1cnnn1Cc1ccccc1)C12CC3CC(CC(C3)C1)C2
Cc1cc(C(=O)NC2CC3(CCN(C(=O)C[C@@H]4CCCC[C@H]4O)C3)C2)on1
CP001858953240
-23.78
O=C(NC1CC2(CCN(C(=O)CC3CCCCC3)C2)C1)c1ccno1
CCc1cnoc1C(=O)NC1CC2(CCN(C(=O)C[C@H]3CCCC[C@@H]3O)C2)C1
CP000746090806
-22.91
O=C(NC1CC2(CCN(C(=O)CC3CCCCC3)C2)C1)c1ccno1
O=C(NC1CC2(CCN(C(=O)CC3(O)CCCCC3)C2)C1)c1ccno1
CP002601789281
-22.56
O=C(NC1CC2(CCN(C(=O)CC3CCCCC3)C2)C1)c1ccno1
Cn1ncc(C(=O)N2CCC(OCCNC(=O)c3ccc(=O)[nH]c3)C2)c1C1CC1
CP000012256521
-24.34
O=C(NCCOC1CCN(C(=O)c2cn[nH]c2C2CC2)C1)c1ccc(=O)[nH]c1
NC(=O)C1(CNC(=O)C2CCN(c3ccccc3)C2)CN(C(=O)C2=COCC2)C1
CP000010862866
-25.38
O=C(NCC1CN(C(=O)C2=COCC2)C1)C1CCN(c2ccccc2)C1
O=C(CNC(=O)c1cccc(OCc2cccnc2)c1)NCCN1CCOCC1
CP000026754351
-36.78
O=C(CNC(=O)c1cccc(OCc2cccnc2)c1)NCCN1CCOCC1
Cc1cc(C(=O)NC[C@H]2C[C@H](NC(=O)c3ccc(=O)oc3)C2)ccn1
CP003062722540
-34.02
O=C(NC[C@H]1C[C@H](NC(=O)c2ccc(=O)oc2)C1)c1ccncc1
Cn1ccc(CCC(=O)N2CC(NC(=O)c3ccncn3)(c3ccccc3)C2)n1
CP000144863874
-29.33
O=C(NC1(c2ccccc2)CN(C(=O)CCc2cc[nH]n2)C1)c1ccncn1
COc1cnc(C(=O)N2CCC(CCNC(=O)c3cnoc3C3CC3)C2)nc1
CP001099565050
-28.55
O=C(NCCC1CCN(C(=O)c2ncccn2)C1)c1cnoc1C1CC1
O=C(NC1C=CCN(C(=O)C2CNc3ccnn3C2)C1)c1cc(C2CC2)no1
CP000753077006
-25.64
O=C(NC1C=CCN(C(=O)C2CNc3ccnn3C2)C1)c1cc(C2CC2)no1
COCc1cncc(C(=O)NCC2(NC(=O)Cc3ccnc(N)c3)CC2)c1
CP002202371147
-50.64
O=C(Cc1ccncc1)NC1(CNC(=O)c2cccnc2)CC1
CC(C(=O)NC1(CNC(=O)c2cncc(Cl)c2O)CC1)c1ccncc1
CP002709353632
-26.4
O=C(Cc1ccncc1)NC1(CNC(=O)c2cccnc2)CC1
CCc1cc(N2CCC(CCNC(=O)C34CCCC3CCC4)C2)nc(CC)n1
CP000507411013
-30.74
O=C(NCCC1CCN(c2ccncn2)C1)C12CCCC1CCC2
Cc1ncc(CC(=O)N2CC(CC(C)NC(=O)c3cc(CC4CCC4)c[nH]3)C2)o1
CP000125462576
-21.77
O=C(NCCC1CN(C(=O)Cc2cnco2)C1)c1cc(CC2CCC2)c[nH]1
CCc1cc(N2CC(CNC(=O)CC3CC(=O)NC(=O)C3)(OC)C2)nc(C)n1
CP000436163664
-42.49
O=C(CC1CC(=O)NC(=O)C1)NCC1CN(c2ccncn2)C1
CCc1ncnc(N2CC([C@H](C)NC(=O)CC3CC(=O)NC(=O)C3)C2)c1F
CP001458231188
-24.35
O=C(CC1CC(=O)NC(=O)C1)NCC1CN(c2ccncn2)C1
CCOc1cc(N2CC(O)(C(C)NC(=O)CC3CC(=O)NC(=O)C3)C2)ncn1
CP000461184351
-22.92
O=C(CC1CC(=O)NC(=O)C1)NCC1CN(c2ccncn2)C1
C[C@H](NC(=O)CC1CC(=O)NC(=O)C1)C1CN(c2ccnc(C(F)(F)F)n2)C1
CP000457021859
-18.84
O=C(CC1CC(=O)NC(=O)C1)NCC1CN(c2ccncn2)C1
CCCc1cc(C(=O)N2CCCCC2C(C)Nc2ncnc3scnc23)[nH]n1
CP000484587549
-31.54
O=C(c1ccn[nH]1)N1CCCCC1CNc1ncnc2scnc12
CC(Nc1ncnc2scnc12)C1CCCCN1C(=O)c1ccnn1C
CP002040317386
-25.52
O=C(c1ccn[nH]1)N1CCCCC1CNc1ncnc2scnc12
Cc1nn(C(C)C)cc1C(=O)NCCn1cc(C2(O)CC3CCC2C3)nn1
CP001173113521
-20.58
O=C(NCCn1cc(C2CC3CCC2C3)nn1)c1cn[nH]c1
Cc1nc(C(=O)NC2CCCC(NC(=O)c3ncn4cccnc34)C2)c(C)s1
CP001247160193
-27.65
O=C(NC1CCCC(NC(=O)c2ncn3cccnc23)C1)c1cscn1
Cc1nc(C(=O)NC2CCCC(NC(=O)c3ncn4cccnc34)C2)cs1
CP002061531985
-23.91
O=C(NC1CCCC(NC(=O)c2ncn3cccnc23)C1)c1cscn1
CCOCCC1(C(=O)NCC2C3CN(CC(OC)C4CCC4)CC23)CCC1
CP001583648140
-26.22
O=C(NCC1C2CN(CCC3CCC3)CC12)C1CCC1
COc1cc(C(=O)NC[C@H]2CCCN(C(=O)CC3CC4CCC3C4)C2)ccc1C
CP000184499076
-30.77
O=C(NC[C@H]1CCCN(C(=O)CC2CC3CCC2C3)C1)c1ccccc1
Cc1cc(C(=O)NCC23CC(CO2)N(C(=O)c2cn(C)c(=O)n2C)C3)[nH]n1
CP002132582708
-21.94
O=C(NCC12CC(CO1)N(C(=O)c1c[nH]c(=O)[nH]1)C2)c1ccn[nH]1
CN(CC(=O)N1CCCC12CCN(C(=O)c1coc(CO)c1)C2)c1ncccn1
CP000133492511
-23.54
O=C(c1ccoc1)N1CCC2(CCCN2C(=O)CNc2ncccn2)C1
O=C(NCC1CCN1C(=O)c1csc(=O)[nH]1)c1ccc2cccnn12
CP003040539279
-25.09
O=C(NCC1CCN1C(=O)c1csc(=O)[nH]1)c1ccc2cccnn12
CC1(C)CC1C(=O)NCC1CC2(CCC2)CN1C(=O)c1nccn2ccnc12
CP000832326871
-25.58
O=C(NCC1CC2(CCC2)CN1C(=O)c1nccn2ccnc12)C1CC1
CC1(C)C[C@@H]1C(=O)NCC1CC2(CCC2)CN1C(=O)c1nccn2ccnc12
CP000832328620
-24.34
O=C(NCC1CC2(CCC2)CN1C(=O)c1nccn2ccnc12)C1CC1
Cc1nnc(N2CCC[C@]2(C)CNC(=O)Cc2cnn3c2CCCC3)s1
CP002228772555
-26.31
O=C(Cc1cnn2c1CCCC2)NCC1CCCN1c1nncs1
CCn1cc(CCN2CCN(C(=O)C3CN(C)CCO3)CC2)cn1
CP002935758735
-34.92
O=C(C1CNCCO1)N1CCN(CCc2cn[nH]c2)CC1
Cc1c(C(=O)N2CC(C)C(CNC(=O)c3cn(C)cn3)C2)cnc2ncnn12
CP000906408400
-27.83
O=C(NCC1CCN(C(=O)c2cnc3ncnn3c2)C1)c1c[nH]cn1
COCCC1(C(=O)NC[C@H]2C[C@H](NC(=O)c3cc4oc(C)c(C)c4[nH]3)C2)CC1
CP001083026169
-28.79
O=C(N[C@H]1C[C@H](CNC(=O)C2CC2)C1)c1cc2occc2[nH]1
O=C(C1C2CCCC21)N1CCC(CNc2ncc3ccccc3n2)C1
CP002387419570
-26.83
O=C(C1C2CCCC21)N1CCC(CNc2ncc3ccccc3n2)C1
CCc1cccnc1C(=O)NC[C@H]1CCCN(C(=O)COc2ccon2)C1
CP002020506626
-27.13
O=C(NC[C@H]1CCCN(C(=O)COc2ccon2)C1)c1ccccn1
CN(C)c1ccc(C(=O)NCC2N(c3cc(=O)n(C)cn3)CCCC2(C)C)cc1
CP000280511165
-31.41
O=C(NCC1CCCCN1c1cc(=O)[nH]cn1)c1ccccc1
CC(C)[C@@H](O)C(=O)N1CC[C@H](NC(=O)CS(=O)(=O)C2CCCC2)C1
CP003426555450
-19.73
O=C(CS(=O)(=O)C1CCCC1)N[C@H]1CCNC1
CC(C)OCCCC(=O)N1CC[C@H](NC(=O)CS(=O)(=O)C2CCCC2)C1
CP002959157684
-18
O=C(CS(=O)(=O)C1CCCC1)N[C@H]1CCNC1
C[C@H](CNC(=O)C1(C2CCC2)CC1(F)F)NC(=O)c1cnccc1C#N
CP002764009994
-28.76
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CC(CNC(=O)C1(C2CCC2)CC1(F)F)NC(=O)c1cncc(OC(C)C)c1
CP001239222514
-26.04
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CC(C)C(CNC(=O)c1ccc(CO)nc1)NC(=O)C1(C2CCC2)CC1(F)F
CP000690846785
-25.96
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CCC(CNC(=O)c1cnccc1C)NC(=O)C1(C2CCC2)CC1(F)F
CP002615701058
-25.3
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CC(CNC(=O)C1(C2CCC2)CC1)N(C)C(=O)c1cccnc1C(F)(F)F
CP001951585716
-24.38
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
C[C@H](CNC(=O)c1cnccc1O)NC(=O)C1(C2CCC2)CC1
CP003502648203
-24.2
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cncc(O)c1
CP003481660319
-24.12
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CC(CNC(=O)c1cccnc1)N(C)C(=O)C1(C2CCC2)CC1(F)F
CP003172002750
-23.04
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
C[C@@H](CNC(=O)C1(C2CCC2)CC1)NC(=O)c1cccnc1
CP003179373151
-22.86
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CNc1ccc(C(=O)NCCN(C)C(=O)C2(C3CCC3)CC2(F)F)cn1
CP002941156828
-22.35
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
Cc1cncc(C(=O)NC(CNC(=O)C2(C3CCC3)CC2)CC(C)C)c1
CP002634194933
-22.16
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
Cc1nc(O)ccc1C(=O)NCCN(C)C(=O)C1(C2CCC2)CC1
CP003420484025
-22.12
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CNc1ccc(C(=O)N(CCNC(=O)C2(C3CCC3)CC2)CCOC)cn1
CP001637851056
-22.01
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CCSc1ccc(C(=O)N(C)CCNC(=O)C2(C3CCC3)CC2(F)F)cn1
CP002108078194
-21.82
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CC(C)Oc1ncccc1C(=O)NCCN(C)C(=O)C1(C2CCC2)CC1(F)F
CP001092186873
-21.61
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
COc1ccncc1C(=O)N(C)CCN(C(=O)C1(C2CCC2)CC1)C(C)C
CP001633584181
-21.46
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CC(CN(C)C(=O)C1(C2CCC2)CC1)NC(=O)c1cccnc1O
CP003396185536
-21.45
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
C[C@@H](CNC(=O)C1(C2CCC2)CC1)NC(=O)c1ccc(C(=O)N(C)C)nc1
CP002191065712
-20.16
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CCOc1ccc(C(=O)N(CC)CCNC(=O)C2(C3CCC3)CC2(F)F)cn1
CP001064340531
-19.09
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CN(CCN(C)C(=O)C1(C2CCC2)CC1(F)F)C(=O)c1cccnc1O
CP002829572682
-14.32
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CN(CCN(C)C(=O)C1(C2CCC2)CC1)C(=O)c1cnccc1O
CP003439320654
-12.26
O=C(NCCNC(=O)C1(C2CCC2)CC1)c1cccnc1
CC(CNC(=O)C(C)Cn1ccnc1)NC(=O)C1CC2(CCOC2)C1
CP003316975955
-42.18
O=C(CCn1ccnc1)NCCNC(=O)C1CC2(CCOC2)C1
Cc1ccc(CN2CCCC3(CCN(C(=O)CCc4cncc(F)c4)C3)C2)cc1
CP000196605657
-38.94
O=C(CCc1cccnc1)N1CCC2(CCCN(Cc3ccccc3)C2)C1
C=C1CC(C)(C(=O)NC2CN(C(=O)c3cc(O)cnc3N)C3CCCCC23)C1
CP000582398038
-23.75
C=C1CC(C(=O)NC2CN(C(=O)c3cccnc3)C3CCCCC23)C1
C=C1CC(C)(C(=O)NC2CN(C(=O)c3cccnc3OC)C3CCCCC23)C1
CP000582397605
-23.53
C=C1CC(C(=O)NC2CN(C(=O)c3cccnc3)C3CCCCC23)C1
CCN(CCCNC(=O)c1cc(F)ccc1C)C(=O)c1ccc2nnc(C)n2c1
CP000157195102
-37.37
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CCN(CCCNC(=O)c1ccc2nncn2c1)C(=O)c1cccc(CF)c1
CP001021693923
-35.57
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1ccc(C(=O)NCC(O)CNC(=O)c2ccc3nncn3c2)cc1C
CP002097580750
-35.32
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1ccc(C(=O)NC(C)CCNC(=O)c2ccc3nncn3c2)cc1
CP002875393890
-35.08
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CC(CNC(=O)c1ccc2nncn2c1)CNC(=O)c1ccc(N)cc1O
CP001945465670
-33.96
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Nc1ccc(C(=O)NCCCNC(=O)c2ccc3nncn3c2)cc1
CP003259712768
-32.91
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CN(CCCNC(=O)c1ccc2nncn2c1)C(=O)c1cc(Cl)ccc1N
CP001962800528
-32.5
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1nnc2ccc(C(=O)NCCCNC(=O)c3cccc(CF)c3)cn12
CP002330544375
-31.38
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1cc(Cl)cc(C)c1C(=O)NCCCNC(=O)c1ccc2nnc(C)n2c1
CP001189755493
-31.08
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1cc(C#N)cc(C)c1C(=O)NCCCNC(=O)c1ccc2nnc(C)n2c1
CP000352713604
-30.81
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CN(CCCNC(=O)c1ccc2nncn2c1)C(=O)c1ccc(C(F)F)cc1
CP001016614858
-30.72
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CC(CCNC(=O)c1ccc2nncn2c1)N(C)C(=O)c1ccc(C#N)cc1
CP000735491184
-30.66
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CN(CCCNC(=O)c1ccc(C#N)cc1F)C(=O)c1ccc2nncn2c1
CP001210768989
-30.59
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1ccc(C(=O)N(C)C(C)CCNC(=O)c2ccc3nncn3c2)cc1F
CP000735491051
-29.95
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1ccc(F)c(C(=O)NCCCN(C)C(=O)c2ccc3nnc(C)n3c2)c1
CP001017516284
-29.95
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
COc1ccc(C(=O)N(C)CCCNC(=O)c2ccc3nnc(C)n3c2)c(N)c1
CP000154973177
-29.46
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
C[C@@H](CCNC(=O)c1cccc(C#CCO)c1)NC(=O)c1ccc2nncn2c1
CP000052416101
-28.61
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1nnc2ccc(C(=O)NC(C)CCNC(=O)c3ccccc3CO)cn12
CP001059086075
-28.34
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
C[C@@H](CCNC(=O)c1ccc2nncn2c1)NC(=O)c1ccc(N)c(F)c1
CP001883704535
-28.23
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1c(Cl)cccc1C(=O)N[C@@H](C)CCNC(=O)c1ccc2nnc(C)n2c1
CP000805833976
-28.01
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Nc1ccc(C(=O)NCCCNC(=O)c2ccc3nncn3c2)c(F)c1
CP002814632089
-27.78
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1ccc(F)cc1C(=O)N(C)CCCNC(=O)c1ccc2nncn2c1
CP001962800290
-27
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1cccc(C(=O)N[C@@H](C)CCNC(=O)c2ccc3nncn3c2)c1F
CP001883704364
-26.82
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
C[C@@H](CCNC(=O)c1ccc2nncn2c1)NC(=O)c1cc(Cl)ccc1N
CP001883704517
-26.36
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
Cc1ccc(C(=O)NCCC(C)N(C)C(=O)c2ccc3nncn3c2)cc1C
CP000735274752
-26.11
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
O=C(NCC(O)CNC(=O)c1cccc(O)c1F)c1ccc2nncn2c1
CP002097890691
-26
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1
CN(CCCNC(=O)c1cc(N)cc(N)c1)C(=O)c1ccc2nncn2c1
CP002197381815
-25.75
O=C(NCCCNC(=O)c1ccc2nncn2c1)c1ccccc1