clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
Cc1ccc(NCC(=O)NC(C)CC(C)NC(=O)c2cnc(C)s2)cc1
CP002351309633
-32.59
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
COCc1ncsc1C(=O)NCC(C)CN(C)C(=O)CNc1ccccc1
CP002024278470
-32.25
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
CCN(CC(=O)NCCCNC(=O)c1cnc(C#N)s1)c1ccccc1
CP002814491440
-30.74
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
COc1cccc(NCC(=O)NC(C)CCNC(=O)c2cncs2)c1
CP003203051429
-30.45
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
COc1cccc(NCC(=O)N(CCCNC(=O)c2cncs2)C(C)C)c1
CP002109425787
-28.77
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
CN(CCCNC(=O)c1scnc1Cl)C(=O)CNc1ccccc1
CP003152397528
-28.54
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
Cc1ccc(NCC(=O)NCCC(C)NC(=O)c2cncs2)cc1
CP003440778388
-28.18
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
CCN(CCCNC(=O)c1scnc1C)C(=O)CNc1ccc(C)cc1
CP002739864275
-28.02
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
Cc1ccc(NCC(=O)NCCCN(C)C(=O)c2sc(CO)nc2C)cc1
CP002197831403
-25.7
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
Cc1ccc(NCC(=O)NCCCN(C)C(=O)c2cnc(C(C)O)s2)cc1
CP002197663934
-24.4
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
CC(O)c1ncc(C(=O)NCC(O)CNC(=O)CN(C)c2ccccc2)s1
CP002097829856
-22.83
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
Cc1nc(N(C)C)sc1C(=O)NCC[C@H](C)NC(=O)CNc1ccccc1
CP001884806014
-22.05
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
CC(CCNC(=O)CN(C)c1ccccc1)N(C)C(=O)c1scnc1Cl
CP002575194745
-21.71
O=C(CNc1ccccc1)NCCCNC(=O)c1cncs1
Cn1cnc(C(=O)NC(CCCNc2nnc(C(C)(C)C)o2)c2ccccc2)c1
CP000235784359
-22.94
O=C(NC(CCCNc1nnco1)c1ccccc1)c1c[nH]cn1
Cc1noc(CN(C)CCC2CCN(C(=O)CC3CC4CCC3C4)CC2)n1
CP001384045437
-44.51
O=C(CC1CC2CCC1C2)N1CCC(CCNCc2ncno2)CC1
COCc1nc(C(=O)N2CCN(C(=O)c3ccc4ccnn4c3)C[C@@H]2C)co1
CP001258204219
-28.35
O=C(c1ccc2ccnn2c1)N1CCN(C(=O)c2cocn2)CC1
Cc1cc(=O)[nH]cc1C(=O)NCCNC(=O)c1coc(C2CCC2)n1
CP003257827836
-26.07
O=C(NCCNC(=O)c1coc(C2CCC2)n1)c1ccc(=O)[nH]c1
O=C(NCCN1CCC(NC(=O)C2CC=CCC2)CC1)c1ccc2nnnn2c1
CP000266322115
-32.88
O=C(NCCN1CCC(NC(=O)C2CC=CCC2)CC1)c1ccc2nnnn2c1
COC(=O)CCn1nc(C)c(CN(CC2CCOCC2)C2CCC2)c1C
CP000886300619
-23.91
c1n[nH]cc1CN(CC1CCOCC1)C1CCC1
CC(C)c1noc(CCNC(=O)NC2CCCCC23CCNCC3)n1
CP001574583043
-17.65
O=C(NCCc1ncno1)NC1CCCCC12CCNCC2
Cc1nc(C)c(C(=O)N2CCC2CNC(=O)C(C)NC(=O)c2ccoc2)nc1C
CP000141857128
-25.92
O=C(CNC(=O)c1ccoc1)NCC1CCN1C(=O)c1cnccn1
CN(C[C@H]1CCCCN1C(=O)c1cccc(C(N)=O)n1)C(=O)Cc1cnnn1C
CP000028825417
-27.34
O=C(Cc1cnn[nH]1)NC[C@H]1CCCCN1C(=O)c1ccccn1
O=C(Cc1ccn[nH]1)NC[C@H]1CC[C@H](NC(=O)c2cnn3c2CCCC3)CC1
CP000913437474
-23.42
O=C(Cc1ccn[nH]1)NC[C@H]1CC[C@H](NC(=O)c2cnn3c2CCCC3)CC1
COc1nc(NC(CNC(=O)c2cc(O)ccn2)C2CC2)nc(OC)n1
CP002042243337
-25.82
O=C(NCC(Nc1ncncn1)C1CC1)c1ccccn1
CCCC(C)(C)C(=O)N1CC[C@@H](NC(=O)C2CCCc3ncnn32)C1
CP003262877753
-25.94
O=C(N[C@@H]1CCNC1)C1CCCc2ncnn21
CCCOCCCC(=O)N1CC[C@@H](NC(=O)C2CCCc3ncnn32)C1
CP002820864677
-24.38
O=C(N[C@@H]1CCNC1)C1CCCc2ncnn21
CN(C(=O)C1CCc2[nH]ncc2C1)C1CCN(C(=O)Cc2cc[nH]c2)CC1
CP001973580210
-26.53
O=C(NC1CCN(C(=O)Cc2cc[nH]c2)CC1)C1CCc2[nH]ncc2C1
CCc1c[nH]cc1C(=O)N1CC2(C1)CN(C(=O)C1(CC)CCNC1=O)CCO2
CP000954657366
-14.76
O=C1NCCC1C(=O)N1CCOC2(CN(C(=O)c3cc[nH]c3)C2)C1
Cc1nn(C)cc1CN1Cc2ccccc2CC1CNC(=O)C1COCCN1C
CP000077861419
-31.85
O=C(NCC1Cc2ccccc2CN1Cc1cn[nH]c1)C1COCCN1
Cc1ccn(CC(=O)N[C@H](C)C2CN(C(=O)CC3C=CCC3)C2)n1
CP003392659542
-23.58
O=C(Cn1cccn1)NCC1CN(C(=O)CC2C=CCC2)C1
Cc1c(Cl)cnn1CC(=O)NC(C)C1(O)CN(C(=O)CC2C=CCC2)C1
CP002652515168
-22.52
O=C(Cn1cccn1)NCC1CN(C(=O)CC2C=CCC2)C1
Cc1cnn(CC(=O)N[C@H](C)C2CN(C(=O)CC3C=CCC3)C2)c1
CP003392310862
-21.89
O=C(Cn1cccn1)NCC1CN(C(=O)CC2C=CCC2)C1
Cn1cc(-c2ccc(C(=O)NC3(C)CN(c4nccc(CC#N)n4)C3)o2)cn1
CP000442538566
-28.87
O=C(NC1CN(c2ncccn2)C1)c1ccc(-c2cn[nH]c2)o1
Cn1ncc2c(=O)[nH]c(NC(C)(C)CNC(=O)CC3CCC4(CCC4)O3)nc21
CP000442324958
-27.04
O=C(CC1CCC2(CCC2)O1)NCCNc1nc2[nH]ncc2c(=O)[nH]1
CC1(C)COC(=O)C1NC(=O)c1ccc2ocnc2c1
CP002478282808
-18.22
O=C(NC1CCOC1=O)c1ccc2ocnc2c1
CC1=NC(C(=O)N(C)CC2CCCN2C(=O)c2coc(=O)[nH]2)CS1
CP003334946384
-16.74
O=C(NCC1CCCN1C(=O)c1coc(=O)[nH]1)C1CSC=N1
Cc1n[nH]c(CC(=O)N[C@@H](C)CNC(=O)CCC(=O)c2ccccc2)n1
CP002836214750
-24.91
O=C(CCC(=O)c1ccccc1)NCCNC(=O)Cc1ncn[nH]1
O=C(N[C@H]1C[C@@H](CNc2nc3cc(Br)ccc3o2)C1)C1(O)CC1
CP002911415841
-29.79
O=C(N[C@H]1C[C@@H](CNc2nc3ccccc3o2)C1)C1CC1
C=CCC1(C(=O)N[C@H]2C[C@@H](CNc3nc4cccc(C)c4o3)C2)CC1
CP002461862444
-22.42
O=C(N[C@H]1C[C@@H](CNc2nc3ccccc3o2)C1)C1CC1
CC(=Cc1ccccn1)C(=O)N[C@@H](C)CCNC(=O)C#CC1CC1
CP003411332250
-27.3
O=C(C#CC1CC1)NCCCNC(=O)C=Cc1ccccn1
CCn1nc(C2CC2)cc1C(=O)NCC1(OC)CN(C(=O)c2nccnc2N)C1
CP000048116676
-25.83
O=C(NCC1CN(C(=O)c2cnccn2)C1)c1cc(C2CC2)n[nH]1
Cc1csc2c(NCC(C3CC3)N(C)C(=O)C3CCC(C)O3)ncnc12
CP001922941578
-28.14
O=C(NC(CNc1ncnc2ccsc12)C1CC1)C1CCCO1
O=C(N[C@H]1C[C@@H](NC(=O)c2ccnc(C3CC3)c2)C1)c1cnoc1
CP003451640543
-25.37
O=C(N[C@H]1C[C@@H](NC(=O)c2ccnc(C3CC3)c2)C1)c1cnoc1
CCc1[nH]ccc1C(=O)N1CCC[C@H](CNC(=O)C=C2CCC(C)CC2)C1
CP002021272456
-26.16
O=C(C=C1CCCCC1)NC[C@H]1CCCN(C(=O)c2cc[nH]c2)C1
Cc1cn2nc(NCCC(C)NC(=O)CC3CCN(C(C)C)CC3)sc2n1
CP001430060963
-46.75
O=C(CC1CCNCC1)NCCCNc1nn2ccnc2s1
CCc1ccc(C=CC(=O)N[C@H]2C[C@H](CNC(=O)c3n[nH]c(COC)n3)C2)cc1
CP000099213214
-28.49
O=C(C=Cc1ccccc1)N[C@H]1C[C@H](CNC(=O)c2nc[nH]n2)C1
Cc1nnccc1C(=O)N1CCC[C@H](CNC(=O)C2CCCCN2C(N)=O)C1
CP000840209095
-25.9
O=C(NC[C@H]1CCCN(C(=O)c2ccnnc2)C1)C1CCCCN1
COc1nsc(OC)c1C(=O)NCC1(CCNC(=O)C2CC(C)(F)C2)CC1
CP001598765357
-24.25
O=C(NCC1(CCNC(=O)C2CCC2)CC1)c1cnsc1
Cc1nsc(N)c1C(=O)NCC1(CCNC(=O)C2(C(F)F)CCC2)CC1
CP002356362494
-21.92
O=C(NCC1(CCNC(=O)C2CCC2)CC1)c1cnsc1
Cc1nscc1C(=O)NCC1(CCNC(=O)C2CCC2)CC1
CP003479627203
-21.56
O=C(NCC1(CCNC(=O)C2CCC2)CC1)c1cnsc1
Cc1cc(F)cc(C(=O)N2CCCCC(NC(=O)CCOc3ccccc3)C2)c1
CP000374759827
-31.64
O=C(CCOc1ccccc1)NC1CCCCN(C(=O)c2ccccc2)C1
CC(C)n1cc(C(=O)N[C@H]2[C@@H]3CN(C(=O)c4cc5n(n4)CCCC5)C[C@@H]32)nn1
CP001132566911
-25.96
O=C(N[C@H]1[C@@H]2CN(C(=O)c3cc4n(n3)CCCC4)C[C@@H]21)c1c[nH]nn1
Cn1c(=O)[nH]c2cc(C(=O)NC3CCCCCN(C(=O)C45CC4C5)C3)ccc21
CP000558886275
null
O=C(NC1CCCCCN(C(=O)C23CC2C3)C1)c1ccc2[nH]c(=O)[nH]c2c1
Cn1c(=O)[nH]c2ccc(C(=O)NC3CCCCCN(C(=O)C45CC4C5)C3)cc21
CP000558886312
null
O=C(NC1CCCCCN(C(=O)C23CC2C3)C1)c1ccc2[nH]c(=O)[nH]c2c1
CC(C)(C)n1cc(C(=O)NC[C@H]2C[C@H](NC(=O)c3occc3C3CC3)C2)cn1
CP001082319978
-24.7
O=C(NC[C@H]1C[C@H](NC(=O)c2occc2C2CC2)C1)c1cn[nH]c1
CCCN1CCN(C(=O)c2n[nH]c3ncccc23)CC1
CP002486210757
-46.39
O=C(c1n[nH]c2ncccc12)N1CCNCC1
CC(C)(C)OCCCN1CCN(C(=O)c2n[nH]c3ncccc23)CC1
CP001224570401
-42.05
O=C(c1n[nH]c2ncccc12)N1CCNCC1
O=C(NCC1CCCN(C(=O)C2CCCCC2O)CC1)c1cc2ccccn2c1
CP000124026905
-28.6
O=C(NCC1CCCN(C(=O)C2CCCCC2)CC1)c1cc2ccccn2c1
Cc1cc(F)c(C(=O)N2CCOCC2CN(C)C(=O)COCC2CC2)cc1F
CP000585272858
-27.39
O=C(COCC1CC1)NCC1COCCN1C(=O)c1ccccc1
Cc1cccc(CCCNC(=O)C2CCCCN2C(=O)OC(C)(C)C)n1
CP001044149516
-21.68
O=C(NCCCc1ccccn1)C1CCCCN1
CC1CC1C(=O)N1C[C@]2(C)CN(C(=O)c3cc(O)c4ccoc4c3)C[C@]2(C)C1
CP001080064797
-23.22
O=C(c1ccc2ccoc2c1)N1CC2CN(C(=O)C3CC3)CC2C1
Cc1cccc(-c2nnc3n2CC(C(=O)NCC#Cc2ccccc2)CC3)c1
CP000391252906
-28.09
O=C(NCC#Cc1ccccc1)C1CCc2nnc(-c3ccccc3)n2C1
CSC1(C(=O)NC(CNC(=O)COCc2ccnn2C)C2CCCC2)CC1
CP001793134503
-25.01
O=C(COCc1ccn[nH]1)NCC(NC(=O)C1CC1)C1CCCC1
CC1(C)CC2(CC(C(=O)N3CCCC(C)(CNC(=O)C45CC4C5)C3)C2)C1
CP002724071645
-21.38
O=C(C1CC2(CCC2)C1)N1CCCC(CNC(=O)C23CC2C3)C1
N#Cc1ccc(CN2CCC(NCC3COCc4ccccc43)CC2)cc1
CP000528048109
-29.95
c1ccc(CN2CCC(NCC3COCc4ccccc43)CC2)cc1
Cc1ccc2c(C(=O)NC3COC4(C3)CN(C(=O)c3cnnn3C)C4)c[nH]c2c1
CP000112662999
-23.46
O=C(NC1COC2(C1)CN(C(=O)c1cnn[nH]1)C2)c1c[nH]c2ccccc12
CC1CC(NC(=O)c2cc(O)ccn2)CN1C(=O)c1cnc2c(F)cccn12
CP000780755322
-40.76
O=C(NC1CCN(C(=O)c2cnc3ccccn23)C1)c1ccccn1
Cc1cnc(C(=O)N(C)C2CCN(C(=O)c3c(C)nc4ccccn34)C2)cc1C
CP000356292875
-33.49
O=C(NC1CCN(C(=O)c2cnc3ccccn23)C1)c1ccccn1
CNc1ccc(C(=O)N(C)C2CCN(C(=O)c3c(C)nc4ccccn34)C2)nc1
CP000356293090
-31.35
O=C(NC1CCN(C(=O)c2cnc3ccccn23)C1)c1ccccn1
Cc1nc2ccccn2c1C(=O)N1CCC(N(C)C(=O)c2ccc(CO)cn2)C1
CP000356293159
-30.83
O=C(NC1CCN(C(=O)c2cnc3ccccn23)C1)c1ccccn1
O=C(NC1CCN(C(=O)c2cnc3c(Cl)cccn23)C1)c1ccc(CO)cn1
CP001243126217
-30.23
O=C(NC1CCN(C(=O)c2cnc3ccccn23)C1)c1ccccn1
Nc1ccc(C(=O)NC2CCN(C(=O)c3c(Cl)nc4ccccn34)C2)nc1
CP002311654546
-28.65
O=C(NC1CCN(C(=O)c2cnc3ccccn23)C1)c1ccccn1
Cc1ccc(C)c(C(=O)NC2(C)CCN(C(=O)c3c(C)nc4ccccn34)C2)n1
CP000088692350
-27.61
O=C(NC1CCN(C(=O)c2cnc3ccccn23)C1)c1ccccn1
Cc1nc2ccccn2c1C(=O)N1CCC(NC(=O)c2ncccc2Cl)C1
CP002313499783
-27.39
O=C(NC1CCN(C(=O)c2cnc3ccccn23)C1)c1ccccn1
COc1ccn2c(C(=O)N3CCC(NC(=O)c4ncccc4OC)C3)cnc2c1
CP000365472414
-25.58
O=C(NC1CCN(C(=O)c2cnc3ccccn23)C1)c1ccccn1
CC(C)Cn1cc(CNC(=O)CN2C(=O)C(=O)N(C)C2=O)nn1
CP001417486015
-23.93
O=C(CN1C(=O)NC(=O)C1=O)NCc1c[nH]nn1
CCCc1nsc(N2CCC(CF)(NC(=O)c3cn4cnnc4cn3)C2)n1
CP001402867637
-25.36
O=C(NC1CCN(c2ncns2)C1)c1cn2cnnc2cn1
CN(CCNC(=O)c1ccn2ccnc2c1)C(=O)CCc1ncccn1
CP002891113641
-24.57
O=C(CCc1ncccn1)NCCNC(=O)c1ccn2ccnc2c1
Cc1nn(C)c(Cl)c1CN1CC2(CCC(O)CC2)C1
CP002860165694
-42.43
c1n[nH]cc1CN1CC2(CCCCC2)C1
COC1(CC(=O)N2CCN(CCCc3nc(-c4ccc(C)cc4)no3)CC2)CC1
CP000027173312
-34.37
O=C(CC1CC1)N1CCN(CCCc2nc(-c3ccccc3)no2)CC1
CCC1CC1C(=O)N1CCC2(CCCC2NC(=O)c2cccc(OC)n2)CC1
CP000813334491
-27.98
O=C(NC1CCCC12CCN(C(=O)C1CC1)CC2)c1ccccn1
CCC1CC1C(=O)N1CCC2(CCCC2NC(=O)c2ccc(C)c(C)n2)CC1
CP000813364395
-27.2
O=C(NC1CCCC12CCN(C(=O)C1CC1)CC2)c1ccccn1
Cc1cc(Cl)nc(C(=O)NC2CCCC23CCN(C(=O)C2CC2)CC3)c1
CP002638789674
-25.78
O=C(NC1CCCC12CCN(C(=O)C1CC1)CC2)c1ccccn1
CC[C@@H]1C[C@H]1C(=O)N1CCC2(CCCC2NC(=O)c2ccccn2)CC1
CP002638701489
-22.53
O=C(NC1CCCC12CCN(C(=O)C1CC1)CC2)c1ccccn1
C[C@@H](CNC(=O)c1cc(C2(C)CC2)n[nH]1)NC(=O)c1csnc1Cl
CP003394232811
-22.57
O=C(NCCNC(=O)c1cc(C2CC2)n[nH]1)c1cnsc1
COC(=O)Cc1nnc(NC(=O)c2cc3cnn(C(C)C)c3nc2C)[nH]1
CP000874889707
-23.73
O=C(Nc1nnc[nH]1)c1cnc2[nH]ncc2c1
O=C(NCC1(CO)CC2(CCC2)C1)Nc1nccc2[nH]c(=O)[nH]c12
CP001329560156
-24.88
O=C(NCC1CC2(CCC2)C1)Nc1nccc2[nH]c(=O)[nH]c12
COc1cc(C=CC(=O)OCc2cc(=O)n3ccccc3n2)ccc1OC(C)C
CP000004038780
-27.89
O=C(C=Cc1ccccc1)OCc1cc(=O)n2ccccc2n1
N#Cc1cnc(N2CC3C(CNC(=O)C4=CCS(=O)(=O)C4)C3C2)c(F)c1
CP001921239310
-24.51
O=C(NCC1C2CN(c3ccccn3)CC12)C1=CCS(=O)(=O)C1
Cc1n[nH]c(C(=O)N2CCN(C(=O)C3CC4CCC(C4)C3)CC(O)C2)c1N
CP002032150158
-18.6
O=C(c1ccn[nH]1)N1CCCN(C(=O)C2CC3CCC(C3)C2)CC1
CN1CCN(C(=O)CNC(=O)CCC2CCCC2)C2(CCCCC2)C1
CP001153639770
-31.9
O=C(CCC1CCCC1)NCC(=O)N1CCNCC12CCCCC2
Cn1nc(C(=O)NC2CCN(C(=O)C3CCCOC3)CC2)nc1O
CP003151917160
-27.91
O=C(NC1CCN(C(=O)C2CCCOC2)CC1)c1nc[nH]n1
COC1(C(=O)N2CCC(N(CCO)C(=O)c3ncn(C)n3)CC2)CCCOC1
CP000562222038
-23.49
O=C(NC1CCN(C(=O)C2CCCOC2)CC1)c1nc[nH]n1
O=C(NCC1CCN1C(=O)C1CCCc2ccnn21)c1ccc2cnsc2c1
CP001254399107
-27.66
O=C(NCC1CCN1C(=O)C1CCCc2ccnn21)c1ccc2cnsc2c1
Cc1ccc(CN2CCOC(CNCC(O)C3CCCO3)C2)cc1
CP002375498554
-53.58
c1ccc(CN2CCOC(CNCCC3CCCO3)C2)cc1
C=C1CCC(C(=O)NC2CCN(C(=O)C3CCC4(CC3)N=N4)CC2C)CC1
CP001880270229
-20.97
C=C1CCC(C(=O)NC2CCN(C(=O)C3CCC4(CC3)N=N4)CC2)CC1
CC1(C)CN(C(=O)C2C3CCCC32)CC(CNC(=O)CC2CCCC(=O)N2)O1
CP000749419600
-18.45
O=C(CC1CCCC(=O)N1)NCC1CN(C(=O)C2C3CCCC32)CCO1
CC1OCCCC1C(=O)NC1CC2(CN(C(=O)Cc3ccco3)C2)n2ccnc21
CP000042304650
-21.3
O=C(NC1CC2(CN(C(=O)Cc3ccco3)C2)n2ccnc21)C1CCCOC1
Cn1cccc1C=CC(=O)N1CC(CO)(NC(=O)C2CSCCS2)C1
CP003112812301
-23.07
O=C(NC1CN(C(=O)C=Cc2ccc[nH]2)C1)C1CSCCS1
CCn1ncnc1C(=O)N[C@H]1C[C@H](CNC(=O)C2(OC)CC2)C1
CP003496973942
-23.87
O=C(N[C@H]1C[C@H](CNC(=O)C2CC2)C1)c1ncn[nH]1