clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
C[C@H](NC(=O)C12CCCCN1CCC2)C1CN(C(=O)c2ccc(N(C)C)cn2)C1
CP000084900288
-34.13
O=C(c1ccccn1)N1CC(CNC(=O)C23CCCCN2CCC3)C1
Cc1cc(C#N)cc(C(=O)N2CC([C@@H](C)NC(=O)C34CCCCN3CCC4)C2)n1
CP000094547730
-33.69
O=C(c1ccccn1)N1CC(CNC(=O)C23CCCCN2CCC3)C1
CCCC(=O)NCCN1CCC(NC(=O)CCC(=O)c2cccs2)CC1
CP002685430906
-35.23
O=C(CCC(=O)c1cccs1)NC1CCNCC1
CN(C(=O)CCC(=O)c1cccs1)C1CCN(C(=O)CCCCCF)CC1
CP001719918960
-29.56
O=C(CCC(=O)c1cccs1)NC1CCNCC1
CCC(F)C(=O)N1CCC(NC(=O)CCC(=O)c2cccs2)C(CC)C1
CP002705999958
-26.76
O=C(CCC(=O)c1cccs1)NC1CCNCC1
NCC1(CNC(=O)C(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2)CCC1
CP001293023258
-44.87
O=C(NCC1CCC1)C(=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1
O=C(NCC1(O)CCC1)C(=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1
CP001509490903
-28.45
O=C(NCC1CCC1)C(=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1
O=C(NCC1C2CN(C(=O)CC3CCCCO3)CC12)c1cc[nH]c1C1CCCC1
CP000261022988
-29.64
O=C(NCC1C2CN(C(=O)CC3CCCCO3)CC12)c1cc[nH]c1C1CCCC1
Cc1cc(CC(=O)N2CCN(S(=O)(=O)C3CN(C(=O)C(N)=O)C3)CC2)n[nH]1
CP001977622901
-21.67
O=C(Cc1cc[nH]n1)N1CCN(S(=O)(=O)C2CNC2)CC1
CCc1ccc(C(=O)NC[C@H]2CCCN2C(=O)C23CCC(C)(C2)OC3)s1
CP002500798843
-23.63
O=C(NC[C@H]1CCCN1C(=O)C12CCC(C1)OC2)c1cccs1
CC(=Cc1c[nH]cn1)C(=O)NCC(Nc1nnnn1-c1ccc(C)cc1)C(C)C
CP000299271382
-32.81
O=C(C=Cc1c[nH]cn1)NCCNc1nnnn1-c1ccccc1
Cc1nc(CC(=O)N(C)C2CCN(C(=O)C3CC34CC(C)(C)C4)C2)cs1
CP002729706745
-24.02
O=C(Cc1cscn1)NC1CCN(C(=O)C2CC23CCC3)C1
CC(C(=O)N[C@@H]1CN(C(=O)CSc2nncn2C)C[C@@H]1C)n1cncn1
CP002645897874
-28.16
O=C(Cn1cncn1)N[C@H]1CCN(C(=O)CSc2nnc[nH]2)C1
CC(=Cc1ccncc1)C(=O)N1CCCC(N(C)C(=O)[C@@H]2[C@H]3[C@@H]4CC[C@@H](C4)[C@@H]23)C1
CP000308868453
null
O=C(NC1CCCN(C(=O)C=Cc2ccncc2)C1)[C@@H]1[C@H]2[C@@H]3CC[C@@H](C3)[C@@H]12
Cn1nccc1[C@]1(O)C[C@H]2CC[C@@H](C1)N2C(=O)NCc1ccc(F)nc1
CP001504524966
-24.84
O=C(NCc1cccnc1)N1[C@@H]2CC[C@H]1CC(c1ccn[nH]1)C2
N#Cc1ccc(CC(=O)NC2(CNC(=O)C3COc4ccccc43)CCC2)cn1
CP000218334823
-28.69
O=C(Cc1cccnc1)NC1(CNC(=O)C2COc3ccccc32)CCC1
CC1CCN(C(=O)C2=CCCCO2)CCN1C(=O)Cc1cc(F)c(N)cc1F
CP000760196935
-29.61
O=C(Cc1ccccc1)N1CCCN(C(=O)C2=CCCCO2)CC1
CCN1CCOC(C(=O)NCC2CN(C(=O)Cc3cccc(C4CC4)c3)C2)C1
CP001105579005
-40.55
O=C(NCC1CN(C(=O)Cc2cccc(C3CC3)c2)C1)C1CNCCO1
Cn1nc(C(=O)NC2CCC(CNC(=O)c3cc4ccccn4n3)C2)ccc1=O
CP000192507915
-26.31
O=C(NCC1CCC(NC(=O)c2ccc(=O)[nH]n2)C1)c1cc2ccccn2n1
CC(C)c1ccc(C(=O)NC2CC3CCC2N(C(=O)CC2CSC2)C3)cn1
CP001606506418
-25.41
O=C(NC1CC2CCC1N(C(=O)CC1CSC1)C2)c1cccnc1
O=C(NC1CCC2(CC1)CCN(C(=O)c1cnsc1)C2)C1=COCCO1
CP002595067199
-19.98
O=C(NC1CCC2(CC1)CCN(C(=O)c1cnsc1)C2)C1=COCCO1
Cn1cc(CCC(=O)N2CC(NC(=O)CCCc3ccccc3)C(C)(C)C2)nn1
CP000013505188
-28.04
O=C(CCCc1ccccc1)NC1CCN(C(=O)CCc2c[nH]nn2)C1
CC(CCC(=O)N(C)C1CCN(C(=O)CCc2cn(C)nn2)C1)c1ccccc1
CP000355690694
-27.78
O=C(CCCc1ccccc1)NC1CCN(C(=O)CCc2c[nH]nn2)C1
Cc1ccsc1-c1cn(CC(C)NC(=O)CC23COC(C)(C2)C3)nn1
CP000393123824
-29.8
O=C(CC12COC(C1)C2)NCCn1cc(-c2cccs2)nn1
O=C(NC(CNC(=O)C1CCc2cn[nH]c2C1)C1CCCC1)C1=NOCC1
CP001793135375
-26.29
O=C(NC(CNC(=O)C1CCc2cn[nH]c2C1)C1CCCC1)C1=NOCC1
CN(C(=O)c1ccc2nnnn2c1)C(CNC(=O)c1nncn1C)C1CC1
CP001844968381
-31.57
O=C(NC(CNC(=O)c1nnc[nH]1)C1CC1)c1ccc2nnnn2c1
CC(CCNC(=O)CCc1cn[nH]c1)NC(=O)c1cc2c(cc1N)OCCO2
CP001058518094
-27.93
O=C(CCc1cn[nH]c1)NCCCNC(=O)c1ccc2c(c1)OCCO2
CC(CC(=O)NCCCNC(=O)c1ccc2c(c1)OCCO2)c1cnn(C)c1
CP001189543804
-23.34
O=C(CCc1cn[nH]c1)NCCCNC(=O)c1ccc2c(c1)OCCO2
CCC1CC1C(=O)N1CCCC(NC(=O)c2cccc3nccn23)C1
CP003300331530
-25.81
O=C(NC1CCCN(C(=O)C2CC2)C1)c1cccc2nccn12
CCc1cn2c(C(=O)NC3CCCN(C(=O)C4(CC)CC4)C3)cccc2n1
CP002234330741
-20.43
O=C(NC1CCCN(C(=O)C2CC2)C1)c1cccc2nccn12
CC1(C)CC(NC(=O)c2cccc3nccn23)CN(C(=O)[C@H]2CC2(F)F)C1
CP001785337770
-19.85
O=C(NC1CCCN(C(=O)C2CC2)C1)c1cccc2nccn12
Cc1cc(C(=O)NCc2ccnc(-c3ccccn3)n2)oc1Br
CP001532282716
-29.65
O=C(NCc1ccnc(-c2ccccn2)n1)c1ccco1
CC1(NC(=O)Cc2cc(C3CC3)on2)CCCN(C(=O)C2CC2(C)C)C1
CP002785881908
-24.97
O=C(Cc1cc(C2CC2)on1)NC1CCCN(C(=O)C2CC2)C1
CC1CCC(NC(=O)Cc2cc(C3CC3)on2)CN1C(=O)[C@H]1C[C@@H]1C
CP002422888719
-24.79
O=C(Cc1cc(C2CC2)on1)NC1CCCN(C(=O)C2CC2)C1
CNC(=O)C1(C(=O)N2CCCC(NC(=O)Cc3cc(C4CC4)on3)C2)CC1
CP002233955321
-22.24
O=C(Cc1cc(C2CC2)on1)NC1CCCN(C(=O)C2CC2)C1
C[C@@H](NC(=O)c1ccc2nc(O)cn2c1)C1CN(C(=O)c2cnn(C)c2N)C1
CP000792650925
-30.09
O=C(NCC1CN(C(=O)c2cn[nH]c2)C1)c1ccc2nccn2c1
CCn1ncc(C(=O)N2CC(O)(CNC(=O)c3ccc4nc(C)cn4c3)C2)c1C
CP000092065380
-27.28
O=C(NCC1CN(C(=O)c2cn[nH]c2)C1)c1ccc2nccn2c1
Cc1[nH]ncc1C(=O)N1CC(CNC(=O)c2ccc3nc(O)cn3c2)C1
CP003008095344
-27.13
O=C(NCC1CN(C(=O)c2cn[nH]c2)C1)c1ccc2nccn2c1
CC1CN(C(=O)C2CC(=O)Nc3ncccc32)CC1CNC(=O)C(O)C1CC1
CP000906781479
-20.84
O=C(CC1CC1)NCC1CCN(C(=O)C2CC(=O)Nc3ncccc32)C1
CC1(CC(=O)NCC2CCN(C(=O)C3CC(=O)Nc4ncccc43)C2(C)C)CC1
CP000138696036
-19.62
O=C(CC1CC1)NCC1CCN(C(=O)C2CC(=O)Nc3ncccc32)C1
CC(c1ccsc1)N1CCN(C(=O)C2CCc3nncn3CC2)CC1
CP001156332939
-34.95
O=C(C1CCc2nncn2CC1)N1CCN(Cc2ccsc2)CC1
C=C1CCC1C(=O)N1CC2CCCC(C1)N2C(=O)C(c1cccnc1)C(C)C
CP000865918134
-20.07
C=C1CCC1C(=O)N1CC2CCCC(C1)N2C(=O)Cc1cccnc1
CC1(C#CC(=O)NC2CCCCCN(C(=O)c3ccnc(CO)c3)C2)CCCO1
CP000007938641
null
O=C(C#CC1CCCO1)NC1CCCCCN(C(=O)c2ccncc2)C1
COc1cccc2c(N(CCNC(=O)Cc3ccc(C)s3)C3CC3)ncnc12
CP000506011053
-25.17
O=C(Cc1cccs1)NCCN(c1ncnc2ccccc12)C1CC1
CC(CCNC(=O)Cc1cnns1)N(C)C(=O)CC1OCCCO1
CP003335600313
-19.93
O=C(Cc1cnns1)NCCCNC(=O)CC1OCCCO1
O=C(NC[C@@H]1C[C@H](F)CN1C(=O)c1ccc2nnnn2c1)c1cc(O)ncn1
CP000670334594
-23.08
O=C(NC[C@@H]1CCCN1C(=O)c1ccc2nnnn2c1)c1ccncn1
CC1CC1CC(=O)NC1CCN(C(=O)C(C)N2CCCCCC2)CC1(C)C
CP001878508506
-30.52
O=C(CC1CC1)NC1CCN(C(=O)CN2CCCCCC2)CC1
O=C(CN1CCCCCC1)N1CCC(N(CCO)C(=O)CC2CC2)CC1
CP002804619711
-19.98
O=C(CC1CC1)NC1CCN(C(=O)CN2CCCCCC2)CC1
O=C(NCCNC(=O)c1cccc2nccn12)c1ccc(-c2cnco2)cc1
CP001188387986
-31.89
O=C(NCCNC(=O)c1cccc2nccn12)c1ccc(-c2cnco2)cc1
Cn1cc(CC(=O)NCC2CN(C(=O)[C@@H]3CC3(F)F)CC(C)(C)O2)nn1
CP002603311192
-20.89
O=C(Cc1c[nH]nn1)NCC1CN(C(=O)C2CC2)CCO1
O=C(Cc1cccnc1)NC1CCCN(C(=O)C2CCC3C(C2)C3(F)F)CC1
CP001110112310
-26.02
O=C(Cc1cccnc1)NC1CCCN(C(=O)C2CCC3CC3C2)CC1
CN(C(=O)CCc1nccs1)C1CN(C(=O)c2ccncc2C(F)(F)F)C1
CP002166024661
-29.15
O=C(CCc1nccs1)NC1CN(C(=O)c2ccncc2)C1
CCc1ccc2occ(C(=O)NC3CCCN(C(=O)C(C)N4CCC4)CC3)c2c1
CP000325873682
-43.49
O=C(NC1CCCN(C(=O)CN2CCC2)CC1)c1coc2ccccc12
Cc1nc(C=CC(=O)N(C)C2CN(C(=O)C3CC34CCOC(C)C4)C2)[nH]c1C
CP000837803960
-43.73
O=C(C=Cc1ncc[nH]1)NC1CN(C(=O)C2CC23CCOCC3)C1
CCc1[nH]c(C)nc1C(=O)NCC(NC(=O)C1CC2CC2C1)C1CCCCC1
CP000682848819
-24.61
O=C(NCC(NC(=O)C1CC2CC2C1)C1CCCCC1)c1c[nH]cn1
Cc1nsc(C)c1C(=O)N(C)CC(C)NC(=O)C1(C)CCCc2ccccc21
CP001206572018
-22.9
O=C(NCCNC(=O)C1CCCc2ccccc21)c1cnsc1
Cc1csc(C(=O)N2CCN(C(=O)CCc3ccc(Cl)s3)CC2)c1
CP003142976571
-29.82
O=C(CCc1cccs1)N1CCN(C(=O)c2cccs2)CC1
CC[C@H](C)[C@H](O)C(=O)N1CCOCC(NC(=O)c2ccc3cccnc3n2)C1
CP000999594627
-24.47
O=C(NC1CNCCOC1)c1ccc2cccnc2n1
CCC(C)(OC)C(=O)N1CCOCC(NC(=O)c2ccc3cccnc3n2)C1
CP000999594575
-23.44
O=C(NC1CNCCOC1)c1ccc2cccnc2n1
CCC(C(=O)N1CCOCC(NC(=O)c2ccc3cccnc3n2)C1)N(C)C
CP000999594429
-22.39
O=C(NC1CNCCOC1)c1ccc2cccnc2n1
CCc1nc(C(=O)N[C@H]2C[C@H](NC(=O)c3cccn4ncnc34)C2)c[nH]1
CP002966100915
-30.41
O=C(N[C@H]1C[C@H](NC(=O)c2cccn3ncnc23)C1)c1c[nH]cn1
CCC1CCCCC1OCC(=O)NCCCN(C)C(=O)C1CCCS1
CP003269851775
-23.01
O=C(COC1CCCCC1)NCCCNC(=O)C1CCCS1
C=CCCC(=O)NC1(C2CCN(C3CCN(c4cnn(C)c4)C3=O)CC2)CC1
CP000624245295
-28.35
O=C1C(N2CCC(C3CC3)CC2)CCN1c1cn[nH]c1
CC(C)n1cncc1C(=O)N[C@H]1C[C@](F)(CNc2ncc3[nH]cnc3n2)C1
CP001406202889
-30.13
O=C(NC1CC(CNc2ncc3[nH]cnc3n2)C1)c1cnc[nH]1
CCC(C)(C)c1nnc(N2CC(NC(=O)C3=CCCC3)CC2C)o1
CP002931553669
-25.06
O=C(NC1CCN(c2nnco2)C1)C1=CCCC1
NC1CC(CCNC(=O)C(=O)NCc2ccccc2CN2CCC(O)CC2)C1
CP000480638392
-48.86
O=C(NCCC1CCC1)C(=O)NCc1ccccc1CN1CCCCC1
CN1CCCCC1C(=O)N1CCC(O)(C2(NC(=O)C(F)C3CCC3)CC2)CC1
CP000662562319
-38.88
O=C(CC1CCC1)NC1(C2CCN(C(=O)C3CCCCN3)CC2)CC1
CC(C)(CC#N)C(=O)N1C(CNC(=O)COCC2CCOC2)CC2COCC21
CP000834274336
null
O=C(COCC1CCOC1)NCC1CC2COCC2N1
Cc1cc(CCC(=O)N(C)CC(C)CNC(=O)COc2ccon2)nn1C
CP002024591773
-24.15
O=C(CCc1cc[nH]n1)NCCCNC(=O)COc1ccon1
CC1(C(=O)NCC2CCCN(C(=O)C=Cc3ccco3)CC2)CCC(=O)NC1
CP000856262469
-23.27
O=C1CCC(C(=O)NCC2CCCN(C(=O)C=Cc3ccco3)CC2)CN1
Cc1nc(C)c(C(=O)NC2CC3CCC(C2)N3C(=O)CCC2CCCO2)o1
CP002246102434
null
O=C(NC1CC2CCC(C1)N2C(=O)CCC1CCCO1)c1cnco1
CCc1c(C(=O)N(C)CC2CCCN2C(=O)[C@H]2CCCO2)oc2ccccc12
CP000733552147
-28.07
O=C(NCC1CCCN1C(=O)[C@H]1CCCO1)c1cc2ccccc2o1
CCCN(C(=O)C1CCCS1)C1CCN(C(=O)CC2CCC3CC23)CC1
CP002749947899
-27.89
O=C(NC1CCN(C(=O)CC2CCC3CC23)CC1)C1CCCS1
CCC1(NC(=O)C2CCCS2)CCN(C(=O)CC2CCC3CC23)CC1
CP003091445748
-24.9
O=C(NC1CCN(C(=O)CC2CCC3CC23)CC1)C1CCCS1
CCc1cc(C(=O)N2CCCC3CN(c4cc(C)nc5ncnn45)CCC32)[nH]n1
CP000297721071
-36.22
O=C(c1ccn[nH]1)N1CCCC2CN(c3ccnc4ncnn34)CCC21
O=C(CC1CCC2CC2C1)NCC1CCCN(C(=O)C2(CO)COC2)CC1
CP001776634400
-29.75
O=C(CC1CCC2CC2C1)NCC1CCCN(C(=O)C2COC2)CC1
Cc1oc(-c2ccccc2)nc1CNC(=O)CCC1(C)CC1
CP001676982450
-26.04
O=C(CCC1CC1)NCc1coc(-c2ccccc2)n1
Cc1cc(C(=O)NC2CCN(C(=O)CC3CC4(CCC4)C3)CC2O)nnc1C
CP000564784741
-25.68
O=C(NC1CCN(C(=O)CC2CC3(CCC3)C2)CC1)c1cccnn1
CC1(NC(=O)c2ccc(Cl)nn2)CCN(C(=O)CC2CC3(CCC3)C2)CC1
CP001790553163
-23.75
O=C(NC1CCN(C(=O)CC2CC3(CCC3)C2)CC1)c1cccnn1
CC1(CNC(=O)c2csnn2)CCCN(C(=O)C(C)(O)C2CCC2)C1
CP003296245747
-23.4
O=C(NCC1CCCN(C(=O)CC2CCC2)C1)c1csnn1
Cn1ccc2cccc(C(=O)N3CC=CC(NC(=O)C4CCCC45CCC5)C3)c21
CP000047809616
-24.29
O=C(NC1C=CCN(C(=O)c2cccc3cc[nH]c23)C1)C1CCCC12CCC2
CCC(C(=O)N1CCCC(c2nc(C)no2)C1)N1CCCC1=O
CP001529572115
-19.11
O=C1CCCN1CC(=O)N1CCCC(c2ncno2)C1
CC(CNC(=O)c1cnc2n1CCCCC2)(NC(=O)c1cnco1)C1CC1
CP001935958645
-26.23
O=C(NC(CNC(=O)c1cnc2n1CCCCC2)C1CC1)c1cnco1
O=C(c1ncnc2nc[nH]c12)N1CC2(CCN(C(=O)C(O)c3cccnc3)C2)C1
CP000208579515
-23.1
O=C(Cc1cccnc1)N1CCC2(C1)CN(C(=O)c1ncnc3nc[nH]c13)C2
Cc1cc(C(=O)NCC2(O)CN(C(=O)c3ccc4c(c3)OCO4)C2)c(=O)[nH]n1
CP000708810458
-32.46
O=C(NCC1CN(C(=O)c2ccc3c(c2)OCO3)C1)c1ccn[nH]c1=O
CCCC(=O)N1CCCCC1CCNC(=O)[C@@H]1CCC(=O)N1
CP003178186158
-26.15
O=C1CC[C@@H](C(=O)NCCC2CCCCN2)N1
CN1C(=O)CC[C@H]1C(=O)NCCC1CCCCN1C(=O)C=CCF
CP003437122235
-24.5
O=C1CC[C@@H](C(=O)NCCC2CCCCN2)N1
CN(C)CC(O)CC(=O)N1CCCCC1CCNC(=O)[C@@H]1CCC(=O)N1
CP002824261597
-23.94
O=C1CC[C@@H](C(=O)NCCC2CCCCN2)N1
C[S+]([O-])CCC(=O)N1CCCCC1CCNC(=O)[C@@H]1CCC(=O)N1
CP003437074325
-21.79
O=C1CC[C@@H](C(=O)NCCC2CCCCN2)N1
CC(C)C(=O)N1CCCCC1CCNC(=O)[C@@H]1CCC(=O)N1
CP003178188912
-21.61
O=C1CC[C@@H](C(=O)NCCC2CCCCN2)N1
C=CCC(C)(C)CC(=O)N1CCCC(C)C1CCNC(=O)[C@@H]1CCC(=O)N1
CP001611887257
-20.65
O=C1CC[C@@H](C(=O)NCCC2CCCCN2)N1
CC1CCCN(C(=O)C=CC(N)=O)C1CCNC(=O)[C@@H]1CCC(=O)N1
CP003250314273
-16.81
O=C1CC[C@@H](C(=O)NCCC2CCCCN2)N1
CC1NC(=O)CCC1NC(=O)C(=O)N(C)CCCOc1ccc(Cl)cc1
CP001512909809
-29.04
O=C1CCC(NC(=O)C(=O)NCCCOc2ccccc2)CN1
CN(CC1CN(c2ccnc(C#N)n2)CCO1)C(=O)c1cn(C)nc1C1CCC1
CP000129291961
-26.94
O=C(NCC1CN(c2ccncn2)CCO1)c1c[nH]nc1C1CCC1
CCOc1nc(C(=O)N(C)CC2CCCN(C(=O)C3CC4CCCC43)C2)co1
CP000993562417
-26.78
O=C(NCC1CCCN(C(=O)C2CC3CCCC32)C1)c1cocn1
CC1CCN(C(=O)CC2OCCCO2)CCN1C(=O)COCc1ccnn1C
CP000759111826
-19.19
O=C(COCc1ccn[nH]1)N1CCCN(C(=O)CC2OCCCO2)CC1
CC(C)(C)C1CC(C(=O)N2CCCOC(CNC(=O)C3CSC3)C2)=NO1
CP002353403106
-22.6
O=C(NCC1CN(C(=O)C2=NOCC2)CCCO1)C1CSC1
Cc1cccc(OCCC(=O)N2CC[C@@H](Nc3ncnc4onc(C)c34)C2)c1
CP000482465296
-34.72
O=C(CCOc1ccccc1)N1CC[C@@H](Nc2ncnc3oncc23)C1
CN1CCN(C(=O)CCC(C)(C)O)C(CNC(=O)c2cncc3ccccc23)C1
CP000054787515
-37.78
O=C(NCC1CNCCN1)c1cncc2ccccc12
CCOC(C)C(=O)N1CCN(C)CC1CNC(=O)c1cncc2ccccc12
CP000768223545
-36.59
O=C(NCC1CNCCN1)c1cncc2ccccc12