clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
CCC(F)C(=O)N1CCN(C)CC1CNC(=O)c1c(C)ncc2ccccc12
CP000581946665
-30.4
O=C(NCC1CNCCN1)c1cncc2ccccc12
Cc1ncc2ccccc2c1C(=O)NCC1CN(C(=O)CCC(C)C)CCN1C
CP000072890340
-27.53
O=C(NCC1CNCCN1)c1cncc2ccccc12
C=CC(C)(C)CC(=O)N1CCN(C)C(CNC(=O)c2cncc3ccccc23)C1
CP000072504944
-27.45
O=C(NCC1CNCCN1)c1cncc2ccccc12
C[C@H](CNC(=O)C1=CC2CCCCCC12)NC(=O)C1CCCc2[nH]nnc21
CP002158066740
null
O=C(NCCNC(=O)C1CCCc2[nH]nnc21)C1=CC2CCCCCC12
CC1CCN(C(=O)[C@@H](O)Cc2c[nH]cn2)CC1NC(=O)C(C)(C)c1ccccn1
CP000203462985
-34.98
O=C(Cc1ccccn1)NC1CCCN(C(=O)CCc2c[nH]cn2)C1
O=C(CCc1c[nH]cn1)N1CCCC(N(CCO)C(=O)Cc2ccccn2)C1
CP000556550438
-34.83
O=C(Cc1ccccn1)NC1CCCN(C(=O)CCc2c[nH]cn2)C1
O=C(CN1CCOCC1)NC12COC(CNc3ncnc4[nH]ccc34)(C1)C2
CP001391491233
-36.29
O=C(CN1CCOCC1)NC12COC(CNc3ncnc4[nH]ccc34)(C1)C2
CCc1nocc1C(=O)NC1CCC(NC(=O)C2CCC(=O)C(C)C2)CC1
CP002306108370
-21.4
O=C1CCC(C(=O)NC2CCC(NC(=O)c3cnoc3)CC2)CC1
O=C(NCC1COCCN(C(=O)C2=COCCC2)C1)c1ccnc2ccnn12
CP000750356001
-27.25
O=C(NCC1COCCN(C(=O)C2=COCCC2)C1)c1ccnc2ccnn12
CCc1ccc(C(=O)NCC2CCN(C(=O)CCCc3cccs3)CC2)o1
CP001957545960
-34.11
O=C(NCC1CCN(C(=O)CCCc2cccs2)CC1)c1ccco1
COC(=O)C=Cc1ccc(C(=O)NC2(c3cccc(C#N)c3)CC2)o1
CP001157781374
-37.89
O=C(NC1(c2ccccc2)CC1)c1ccco1
CC(C)(C)OC(=O)NCc1ccc(C(=O)NC2(c3ccc(F)cc3)CC2)o1
CP000514975260
-34.58
O=C(NC1(c2ccccc2)CC1)c1ccco1
CS(=O)(=O)NCc1ccc(C(=O)NC2(c3cc(F)cc(C(=O)O)c3)CC2)o1
CP000527723739
-14.82
O=C(NC1(c2ccccc2)CC1)c1ccco1
COc1ccc(C2(NC(=O)c3cc(C)c(C(=O)O)o3)CC2)cc1
CP001523575211
-14.1
O=C(NC1(c2ccccc2)CC1)c1ccco1
O=C(NC1CCCC1CNC(=O)C1(F)CCCC1)C(CO)c1ccccc1
CP002096614664
-26.65
O=C(Cc1ccccc1)NC1CCCC1CNC(=O)C1CCCC1
COCc1cccc(CC(=O)NC2CCCC2CNC(=O)C2CCCC2C)c1
CP000694048126
-26.59
O=C(Cc1ccccc1)NC1CCCC1CNC(=O)C1CCCC1
Cc1cc(F)cc(C(C)C(=O)NC2CCCC2CNC(=O)C2(F)CCCC2)c1
CP000695520243
-22.57
O=C(Cc1ccccc1)NC1CCCC1CNC(=O)C1CCCC1
O=C(c1cccc2sncc12)N1C[C@@H]2CCCN(C(=O)CCCCF)[C@@H]2C1
CP002004350315
null
O=C(c1cccc2sncc12)N1C[C@@H]2CCCN[C@@H]2C1
CCn1nccc1C=CC(=O)N1CCC[C@H]1CN(C)C(=O)C1Cc2ccccc21
CP000135788440
-24.86
O=C(NC[C@@H]1CCCN1C(=O)C=Cc1ccn[nH]1)C1Cc2ccccc21
CSc1cccc(N2CC(C(=O)Nc3nnc(C4CCCC4)[nH]3)CC2=O)c1
CP000534568370
-32.05
O=C(Nc1nnc(C2CCCC2)[nH]1)C1CC(=O)N(c2ccccc2)C1
Cn1nccc1C1COCCN1C(=O)CCOC1CC1
CP002479704120
-19.09
O=C(CCOC1CC1)N1CCOCC1c1ccn[nH]1
Cc1nn(C(C)(C)C)cc1C(=O)N1CCN(C(=O)OC(C)(C)C)S1(=O)=O
CP001517989562
-21.26
O=C(c1cn[nH]c1)N1CCNS1(=O)=O
Cc1cnc2c(C(=O)N[C@@H](C)CNC(=O)CCc3nc(=O)[nH][nH]3)cnn2c1
CP002104009054
-24.37
O=C(CCc1nc(=O)[nH][nH]1)NCCNC(=O)c1cnn2cccnc12
COc1nn(C)cc1C(=O)NC(C)C1CCN(C(=O)c2cc3ncccc3[nH]2)C1
CP000263122785
-20.07
O=C(NCC1CCN(C(=O)c2cc3ncccc3[nH]2)C1)c1cn[nH]c1
O=C(CN1CCC1)N[C@H]1C[C@@H](NC(=O)C2CNc3ccccc32)C1
CP003451563046
-27.16
O=C(CN1CCC1)N[C@H]1C[C@@H](NC(=O)C2CNc3ccccc32)C1
CCc1cc(C(=O)N(C)C(C)CNC(=O)c2cccc(CCN(C)C)c2)on1
CP001037765309
-56.24
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(C(=O)NC(C)CNC(=O)c2cccc(CN(C)C)c2)on1
CP002979707218
-45.38
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COC(=O)c1ccc(C(=O)N(C)C(C)CNC(=O)c2cc(Cl)no2)cc1F
CP001982649135
-37.11
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COCc1cc(C(=O)N(C)C(C)CNC(=O)c2c(C)cc(Cl)cc2C)on1
CP001953292137
-36.38
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@H](CNC(=O)c1cc(Cl)no1)NC(=O)c1cccc(Cl)c1N
CP003501506934
-35.5
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCOc1cc(C(=O)NCC(NC(=O)c2c(F)cc(N)cc2F)C(C)C)on1
CP000689970317
-35.06
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cnoc1C(=O)NCC(C)N(C)C(=O)c1cc(N(C)C)ccc1N
CP002668788522
-34.82
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(F)cc(C(=O)N(C)C(C)CNC(=O)c2cc(C(N)=O)no2)c1
CP002632098812
-34.82
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1ccc(C(=O)NC[C@@H](C)NC(=O)c2cc(C(=O)OC)no2)cc1Cl
CP002157036249
-34.68
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COC(=O)c1cc(C(=O)N[C@H](C)CNC(=O)c2ccc(Cl)c(C)c2)on1
CP002761709573
-34.65
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cc(C(=O)NCCN(C)C(=O)c2ccccc2CN(C)C)on1
CP002890721853
-34.64
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cnoc1C(=O)N(C)CC(C)NC(=O)c1ccccc1CC(C)(C)C
CP002193203917
-34.36
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cnoc1C(=O)N(C)CC(C)NC(=O)c1cc(Cl)cc(Cl)c1
CP003282283079
-34.23
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cnoc1C(=O)NC[C@@H](C)NC(=O)c1ccc(C#N)cc1
CP003381239694
-34.21
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(=O)c1cc(C(=O)NC[C@@H](C)NC(=O)c2ccno2)ccc1O
CP003441592056
-34.2
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)N[C@@H](C)CNC(=O)c2c(F)cc(N)cc2F)on1
CP003441752913
-34.03
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)NCC(C)N(C)C(=O)c2ccc(C)c(Cl)c2F)on1
CP003170517626
-33.92
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCOc1cc(C(=O)N(C)C(C)CNC(=O)c2cc(Cl)ccc2F)on1
CP002631806208
-33.81
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCCC(CNC(=O)c1cc(Cl)no1)NC(=O)c1ccc(C(F)F)cc1
CP001986610806
-33.76
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(C)c1ccc(C(=O)NCCNC(=O)c2oncc2C)cc1
CP003257097747
-33.72
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@H](CNC(=O)c1cc(Cl)no1)NC(=O)c1ccc(F)cc1Cl
CP003501506402
-33.67
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCC(CNC(=O)c1cc(C)cc(F)c1)NC(=O)c1cc(C(=O)OC)no1
CP002272771429
-33.6
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCOc1cc(C(=O)N(CC)CCNC(=O)c2c(N)cc(Cl)cc2F)on1
CP002100720909
-33.57
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)NC[C@@H](C)NC(=O)c2cc(O)ccc2Cl)on1
CP003501302540
-33.49
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cnoc1C(=O)NC(CNC(=O)c1cccc(Cl)c1C)CC(C)C
CP002634468325
-33.46
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cnoc1C(=O)NC(CNC(=O)c1ccc(Cl)cc1Cl)CC(C)C
CP002634467952
-33.3
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCSc1cccc(C(=O)NCCNC(=O)c2cc(C(C)(C)C)no2)c1
CP002329960515
-33.23
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cnoc1C(=O)N(C)C(C)CNC(=O)c1ccc(Cl)c(C#N)c1
CP003170273524
-33.2
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cnoc1C(=O)NCCN(CC)C(=O)c1ccc(C)cc1Cl
CP003207280472
-33.2
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCSCc1ccc(C(=O)N(C)CCNC(=O)c2oncc2C)cc1
CP003215861068
-33.16
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCN(CCNC(=O)c1cc(Cl)no1)C(=O)c1cc(F)c(CO)c(F)c1
CP002879245300
-33.14
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1cc(Cl)no1)C(=O)c1ccc(Cl)cc1
CP003465327783
-33.11
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(C(=O)N[C@H](C)CNC(=O)c2cc(OC)c(N)cc2F)on1
CP002835214424
-33.08
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1ccc(N)c(C(=O)NCC(C)N(C)C(=O)c2cc(C(N)=O)no2)c1
CP001952109512
-32.86
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)N[C@@H](C)CNC(=O)c2cc(N)c(O)c(F)c2)on1
CP003441753042
-32.85
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@H](CNC(=O)c1ccc(Cl)c(C#N)c1)NC(=O)c1cc(Cl)no1
CP003441325757
-32.74
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)N[C@H](C)CNC(=O)c2ccc(F)cc2)on1
CP003187140300
-32.68
O=C(NCCNC(=O)c1ccno1)c1ccccc1
O=C(NCCNC(=O)c1cc(F)ccc1O)c1cc(Cl)no1
CP003480901942
-32.55
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)N[C@H](C)CNC(=O)c2ccc(C#N)c(Cl)c2)on1
CP003441276263
-32.53
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCSCc1ccc(C(=O)NCCNC(=O)c2cc(C(=O)OC)no2)cc1
CP002329280072
-32.52
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C=CCc1ccccc1C(=O)NC(CCCC)CNC(=O)c1cc(OC)no1
CP000900533911
-32.45
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cnoc1C(=O)NCC(C)N(C)C(=O)c1ccc(NC(N)=O)cc1
CP001950169548
-32.42
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCC(CNC(=O)c1ccno1)NC(=O)c1ccccc1CCN(C)C
CP002618126278
-32.39
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(C(=O)NCCN(C)C(=O)c2c(Cl)cccc2Cl)on1
CP003467359337
-32.34
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCCC(CNC(=O)c1cc(CCC)ccc1N)NC(=O)c1ccno1
CP001987741300
-32.34
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCOc1ccc(C(=O)NCCN(CC)C(=O)c2cc(C)no2)cc1O
CP002834573607
-32.33
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cnoc1C(=O)N(C)CC(C)NC(=O)c1ccc(C(C)C)cc1
CP002840658517
-32.3
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(C(=O)NC(C)CNC(=O)c2cc(C(C)(C)C)no2)cc(N)c1O
CP001238195824
-32.21
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@@H](CNC(=O)c1ccc(NCCO)cc1)NC(=O)c1cc(C(N)=O)no1
CP002190088617
-32.19
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)NC[C@@H](C)NC(=O)c2ccc(Cl)c(O)c2)on1
CP003501302567
-32.18
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(N)c(F)cc1C(=O)NC[C@@H](C)NC(=O)c1cc(C(N)=O)no1
CP002101700664
-32.16
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(C(=O)NCC(C)NC(=O)c2ccc(F)c(C)c2)on1
CP003454809351
-32.14
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cnoc1C(=O)NC(CNC(=O)c1cc(F)c(O)c(F)c1)CC(C)C
CP001954357665
-32.08
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C=CCc1ccccc1C(=O)NC(CNC(=O)c1cc(Cl)no1)C(C)(C)C
CP001635529080
-32.02
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1ccc(C(=O)NC(C)CNC(=O)c2cc(Cl)no2)c(N)c1
CP003454882328
-32
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1oncc1CC)C(=O)c1ccc(N(C)C)cc1
CP002079065882
-31.87
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1cc(Cl)no1)C(=O)c1cc(F)ccc1OC
CP002885592914
-31.85
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCOc1cc(C(=O)NCC(NC(=O)c2ccccc2CO)C(C)C)on1
CP002090817531
-31.82
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(N)c(C(=O)N(C)C(C)CNC(=O)c2cc(Cl)no2)cc1F
CP002668690776
-31.8
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(Cl)c(C(=O)NCC(NC(=O)c2ccno2)C(C)C)c1
CP003438078151
-31.74
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCOc1ccc(N)c(C(=O)N(C)C(C)CNC(=O)c2ccno2)c1
CP003102650640
-31.72
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(C(=O)N[C@@H](C)CNC(=O)c2ccc(N)cc2C)on1
CP003441936447
-31.68
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1ccc(C(=O)N[C@H](C)CNC(=O)c2cc(C(C)C)no2)c(O)c1
CP002761104442
-31.66
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(F)cc(C(=O)NC[C@@H](C)NC(=O)c2cc(Cl)no2)c1N
CP003441325679
-31.64
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cnoc1C(=O)NCC(CC)NC(=O)c1cc(F)c(CO)c(F)c1
CP002273264364
-31.63
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C=CCCCc1ccc(C(=O)NCCN(CCOC)C(=O)c2ccno2)cc1
CP000580716491
-31.63
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cnoc1C(=O)NCC(C)NC(=O)c1cc(C)cc(F)c1
CP003456014975
-31.55
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cnoc1C(=O)NC(CNC(=O)c1cc(Cl)cc(Cl)c1)C(C)(C)C
CP002541478854
-31.52
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)N[C@H](C)CNC(=O)c2ccno2)cc(N)c1O
CP003502560457
-31.5
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cnoc1C(=O)N[C@H](C)CNC(=O)c1cc(F)cc(F)c1
CP003380157502
-31.47
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)NCC(C)N(C)C(=O)c2cc(Cl)no2)cc(N)c1O
CP003169911816
-31.47
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1ccc(C(=O)NCC(NC(=O)c2ccno2)C(C)C)cc1CC
CP002826368150
-31.45
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(C(=O)NCC(CC(C)C)NC(=O)c2ccno2)c(N)c1Cl
CP002821514002
-31.45
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)N[C@H](C)CNC(=O)c2ccccc2CO)on1
CP003502344998
-31.45
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(C(=O)NC[C@H](C)NC(=O)c2cc(C(C)C)no2)c(F)c1Cl
CP002837146009
-31.45
O=C(NCCNC(=O)c1ccno1)c1ccccc1