clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
CCCN(CCNC(=O)c1ccccc1N(C)C(C)=O)C(=O)c1oncc1C
CP001069086930
-18.34
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1c(Cl)cccc1C(=O)NCC(C)NC(=O)c1cc(O)no1
CP003456770223
-17.53
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1cc(O)no1)C(=O)c1ccc(C(C)(F)F)cc1
CP002079240041
-17.33
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CNc1ccc(C(=O)NCC(NC(=O)c2cc(O)no2)C(C)(C)C)cc1F
CP001634897336
-17.17
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CN(CCNC(=O)c1ccno1)C(=O)c1ccccc1OCC(N)=O
CP003214744658
-17.06
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@H](CNC(=O)c1c(F)cccc1Cl)NC(=O)c1cc(O)no1
CP003501511443
-16.92
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C=CCOc1ccc(C(=O)NCCN(CCC)C(=O)c2cc(O)no2)cc1
CP002078872866
-16.81
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCCNc1ccccc1C(=O)NCCN(CC)C(=O)c1cc(O)no1
CP002100918785
-16.47
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cc(C(=O)NCCN(CC)C(=O)c2cc(O)no2)ccc1O
CP003277564675
-16.29
O=C(NCCNC(=O)c1ccno1)c1ccccc1
O=C(NCCNC(=O)c1cc(O)no1)c1cc(Cl)cc(Cl)c1
CP003480909136
-16.1
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(=O)Nc1cccc(C(=O)NCCN(C)C(=O)c2cc(O)no2)c1C
CP002939763209
-16.07
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(CNC(=O)c1ccc(OC(F)F)cc1)NC(=O)c1cc(O)no1
CP003316232683
-15.96
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(CNC(=O)c1cc(O)no1)NC(=O)c1c(N)cccc1Cl
CP003367284930
-15.9
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(CNC(=O)c1ccc(Cl)cc1)NC(=O)c1cc(O)no1
CP003486133719
-15.76
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1ccc(C(=O)NCCNC(=O)c2cc(O)no2)cc1
CP003480912454
-15.72
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@H](CNC(=O)c1cc(O)no1)NC(=O)c1ccc(C#N)cc1
CP003502282604
-15.68
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@H](CNC(=O)c1ccc(F)c(F)c1)NC(=O)c1cc(O)no1
CP003501806507
-15.5
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(C)C(CNC(=O)c1cc(O)no1)NC(=O)c1cc(F)cc(Cl)c1O
CP002827368589
-15.39
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@H](CNC(=O)c1cc(O)no1)NC(=O)c1cc(N)cc(O)c1
CP003502282621
-15.21
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCN(CCNC(=O)c1c(N)cccc1Cl)C(=O)c1cc(O)no1
CP003441167711
-15.2
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCC(CNC(=O)c1ccccc1SC)NC(=O)c1cc(O)no1
CP003429924535
-15.19
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@H](CNC(=O)c1ccccc1CO)NC(=O)c1cc(O)no1
CP003502345287
-15.14
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cnoc1C(=O)NCCNC(=O)c1ccc(F)c(O)c1
CP003481037790
-15.14
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1ccc(C(=O)NCC(C)NC(=O)c2cc(O)no2)c(F)c1
CP003455466905
-15.11
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCSCc1ccccc1C(=O)NC[C@@H](C)NC(=O)c1cc(O)no1
CP003226577037
-15.06
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1c(F)ccc(Cl)c1C(=O)N(C)CCN(C)C(=O)c1cc(O)no1
CP003273995551
-15.05
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCN(CCNC(=O)c1cc(C)cc(F)c1)C(=O)c1cc(O)no1
CP003463160762
-15.04
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(C)CC(CNC(=O)c1cc(Cl)cc(F)c1N)NC(=O)c1cc(O)no1
CP001955087293
-14.96
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCCC(CNC(=O)c1cc(F)cc(Cl)c1N)NC(=O)c1cc(O)no1
CP001987437325
-14.92
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CN(CCNC(=O)c1cc(N)c(Cl)c(O)c1)C(=O)c1cc(Cl)no1
CP003467342354
-14.8
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCOc1cc(C(=O)N(C)CCNC(=O)c2ccc(O)c(F)c2)on1
CP003214778514
-14.69
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1ccc(OC)c(OC)c1C)C(=O)c1cc(O)no1
CP001068937239
-14.63
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(CNC(=O)c1cc(O)no1)NC(=O)c1cc(C#N)ccc1Cl
CP003456173430
-14.5
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1cc(O)no1)C(=O)c1c(C)cc(C#N)cc1C
CP002079240837
-14.38
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COCc1ccccc1C(=O)NCC(C)NC(=O)c1cc(O)no1
CP003455873894
-14.36
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1cc(O)no1)C(=O)c1ccc(F)cc1C
CP003211269569
-14.28
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cccc(C(=O)NC(CNC(=O)c2cc(O)no2)C(C)C)c1F
CP003176210243
-14.28
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(C(=O)NC[C@H](C)NC(=O)c2cc(O)no2)ccc1F
CP003394251133
-14.22
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CN(CCNC(=O)c1cc(O)ccc1Cl)C(=O)c1ccno1
CP003490189926
-14.13
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCC(CNC(=O)c1cc(O)no1)NC(=O)c1cc(OC)ccc1N
CP003161700184
-13.87
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(C)COc1cccc(C(=O)NCC(C)N(C)C(=O)c2cc(O)no2)c1
CP001952277323
-13.83
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cnoc1C(=O)NCC(C)NC(=O)c1cc(F)c(O)c(Cl)c1
CP003455257539
-13.8
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(C(=O)N(C)CCN(C)C(=O)c2cc(O)no2)c(N)c1
CP003439011747
-13.52
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1c(Cl)cccc1C(=O)N(C)CC(C)NC(=O)c1cc(O)no1
CP003396275509
-13.16
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Nc1cccc(Cl)c1C(=O)NCCNC(=O)c1cc(O)no1
CP003481347878
-13.07
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(C(=O)N(C)CC(C)NC(=O)c2cc(O)no2)cc1N
CP003396275620
-13.03
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COCCOc1cccc(C(=O)NC[C@@H](C)NC(=O)c2cc(O)no2)c1
CP002760465674
-13.02
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1cc(C(=O)N(C)C(C)CNC(=O)c2cc(O)no2)ccc1O
CP003415008023
-12.99
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(C)C(CNC(=O)c1cc(C(C)(C)C)no1)NC(=O)c1ccc(O)cc1F
CP000690637806
-12.89
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COCCN(CCNC(=O)c1cc(O)no1)C(=O)c1cc(N)c(Cl)c(O)c1
CP001637052273
-12.89
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCC(CNC(=O)c1cc(O)no1)NC(=O)c1cc(N)cc(N)c1
CP003429910944
-12.85
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCN(CCNC(=O)c1cc(O)no1)C(=O)c1cc(F)cc(F)c1
CP003463434209
-12.6
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(CN(C)C(=O)c1cccc(CO)c1)NC(=O)c1cc(O)no1
CP003396275702
-12.47
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(F)c(C(=O)N(C)C(C)CNC(=O)c2cc(O)no2)c1N
CP003102584151
-12.45
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CN(CCN(C)C(=O)c1cc(Cl)ccc1F)C(=O)c1cc(O)no1
CP003438776203
-12.43
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(C)N(CCN(C)C(=O)c1ccc(CC#N)cc1)C(=O)c1cc(O)no1
CP001632921500
-12.43
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(CN(C)C(=O)c1ccc(Cl)cc1Cl)NC(=O)c1cc(O)no1
CP003396275135
-12.34
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCCC(CNC(=O)c1c(N)cc(F)cc1Cl)NC(=O)c1cc(O)no1
CP001987437288
-12.34
O=C(NCCNC(=O)c1ccno1)c1ccccc1
C[C@H](CNC(=O)c1ccno1)NC(=O)c1cc(F)c(O)c(Cl)c1
CP003502559937
-12.24
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCC(CNC(=O)c1cc(O)no1)NC(=O)c1ccc(NC(N)=O)cc1
CP002617649573
-12.04
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(CN(C)C(=O)c1ccc(Cl)c(O)c1)NC(=O)c1cc(O)no1
CP003396275856
-11.85
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1cccc(Cl)c1Cl)C(=O)c1cc(O)no1
CP003210548964
-11.7
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1cnoc1C(=O)NCCNC(=O)c1cc(C(C)C)ccc1O
CP003258198069
-11.54
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cccc(O)c1C(=O)N[C@H](C)CNC(=O)c1cc(C(C)C)no1
CP002761104620
-10.98
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(C)c1ccc(C(=O)NCCN(C)C(=O)c2cc(C(N)=O)no2)c(O)c1
CP002107456811
-10.26
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COCCN(CCNC(=O)c1ccc([S+](C)[O-])cc1)C(=O)c1cc(O)no1
CP001636948594
-10.23
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(CN(C)C(=O)c1ccc(O)c(Cl)c1)NC(=O)c1cc(O)no1
CP003396275665
-9.97
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCCC(CNC(=O)c1c(O)cccc1O)NC(=O)c1ccno1
CP003104504799
-9.41
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1ccc(C)c(C(=O)NCCN(C)C(=O)c2cc(O)no2)c1N
CP003215718963
-8.57
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCCC(CNC(=O)c1ccccc1O)NC(=O)c1cc(OCC)no1
CP001986911306
-8.24
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(CN(C)C(=O)c1cc(O)no1)NC(=O)c1cccc(F)c1O
CP003373630165
-8.22
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1cccc(C)c1NC(C)=O)C(=O)c1cc(O)no1
CP001069753256
-8.17
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCOc1cccc(C(=O)N(C)CC(C)NC(=O)c2cc(O)no2)c1
CP002842462666
-8.03
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COc1cc(C(=O)N[C@@H](C)CNC(=O)c2cc(F)ccc2O)on1
CP003441936371
-7.34
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1ccc(C(=O)NC[C@H](C)NC(=O)c2cc(COC)no2)c(O)c1
CP002839803772
-5.71
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(O)c(C(=O)NC(C)CN(C)C(=O)c2cc(O)no2)c1
CP003373630142
-1.54
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCCN(CCNC(=O)c1cc(O)no1)C(=O)c1c(F)ccc(O)c1F
CP002886772325
19.91
O=C(NCCNC(=O)c1ccno1)c1ccccc1
COCCN(CCNC(=O)c1cc(COC)no1)C(=O)c1ccc(C)c(N)c1
CP000580729761
null
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(C(=O)N(C)CCNC(=O)c2cc(C(C)C)no2)cc1C(C)(C)C
CP001092416275
null
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(C(=O)NCC(NC(=O)c2cc(O)no2)C(C)(C)C)c(N)c1C
CP001634897026
null
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CC(C)c1cccc(C(=O)N(C)CCN(C)C(=O)c2cc(Cl)no2)c1N
CP002828524665
null
O=C(NCCNC(=O)c1ccno1)c1ccccc1
Cc1ccc(C(=O)N(C)CCN(C)C(=O)c2cc(O)no2)c(N)c1C
CP003273995775
null
O=C(NCCNC(=O)c1ccno1)c1ccccc1
CCc1noc(C)c1C(=O)NC1CN(Cc2ncccc2C)CC1(C)C
CP002345781809
-34.31
O=C(NC1CCN(Cc2ccccn2)C1)c1cnoc1
CCc1onc(C)c1C(=O)NC1CCN(Cc2ccc(F)cn2)C1
CP002937073683
-24.96
O=C(NC1CCN(Cc2ccccn2)C1)c1cnoc1
CC1(C)C(NC(=O)[C@@H]2CC2(F)F)CCN1C(=O)c1ccc2c(c1)NCC2
CP002588524370
-23.22
O=C(NC1CCN(C(=O)c2ccc3c(c2)NCC3)C1)C1CC1
CCC(=O)N1CCC(C2(CNC(=O)CCc3cnoc3)CCOCC2)CC1
CP001784169367
-20.54
O=C(CCc1cnoc1)NCC1(C2CCNCC2)CCOCC1
Cn1nccc1C(O)C(=O)NCC1CC2CCC1N(C(=O)c1cc[nH]n1)C2
CP001601857069
-27.89
O=C(Cc1ccn[nH]1)NCC1CC2CCC1N(C(=O)c1cc[nH]n1)C2
COc1nc(N2CCN(C(=O)C=Cc3c[nH]cn3)CCC2C)nc2ccccc12
CP000291286644
-32.83
O=C(C=Cc1c[nH]cn1)N1CCCN(c2ncc3ccccc3n2)CC1
Cc1ccc(CC(=O)NC[C@@H]2CCCN2C(=O)[C@H](C)n2cnnn2)cc1Cl
CP001645609656
-26.42
O=C(Cc1ccccc1)NC[C@@H]1CCCN1C(=O)Cn1cnnn1
C[C@@H](C(=O)N1CCC[C@H]1CNC(=O)Cc1ccc(C(C)(C)C)cc1)n1cnnn1
CP000118027800
-24.07
O=C(Cc1ccccc1)NC[C@@H]1CCCN1C(=O)Cn1cnnn1
C[C@@H](C(=O)N1C[C@@H](F)C[C@H]1CNC(=O)[C@H](O)c1ccccc1)n1cnnn1
CP001649173564
-22.49
O=C(Cc1ccccc1)NC[C@@H]1CCCN1C(=O)Cn1cnnn1
C[C@@H](C(=O)N1CCC[C@H]1CN(C)C(=O)Cc1cccc(F)c1F)n1cnnn1
CP000597934231
-20.27
O=C(Cc1ccccc1)NC[C@@H]1CCCN1C(=O)Cn1cnnn1
Cc1nnnn1CC(=O)N1CCC[C@H]1CN(C)C(=O)C(C)(C)c1ccccc1
CP000597311698
null
O=C(Cc1ccccc1)NC[C@@H]1CCCN1C(=O)Cn1cnnn1
CCOC(=O)c1cnc(N2CCC(N(CC)C(=O)C=CC3CCOC3)C2)s1
CP001479569983
-29.46
O=C(C=CC1CCOC1)NC1CCN(c2nccs2)C1
CSc1cc(C(=O)N2C3CCC2CN(C(=O)C2CC4CCC2C4)C3)co1
CP002943255110
-24.77
O=C(C1CC2CCC1C2)N1CC2CCC(C1)N2C(=O)c1ccoc1
Cc1nnc(CCC(=O)N2C3CCCC2CN(C(=O)C2CC2(C)C(C)C)C3)o1
CP000864876251
-20.86
O=C(C1CC1)N1CC2CCCC(C1)N2C(=O)CCc1nnco1
COCc1nc(C(=O)NC2CCCC23CN(C(=O)CCn2cncn2)C3)co1
CP000822935813
-24.66
O=C(NC1CCCC12CN(C(=O)CCn1cncn1)C2)c1cocn1
CN(CCCNC(=O)C1(C)CCC(=O)N1)C(=O)C1=Cc2cc(F)ccc2OC1
CP001018374988
-33.27
O=C1CCC(C(=O)NCCCNC(=O)C2=Cc3ccccc3OC2)N1
CN(CCCNC(=O)C1=Cc2cc(F)ccc2OC1)C(=O)C1CCC(=O)N1C
CP001018521620
-32.75
O=C1CCC(C(=O)NCCCNC(=O)C2=Cc3ccccc3OC2)N1
C[C@@]1(C(=O)NCCCNC(=O)C2=Cc3cc(F)ccc3OC2)CCC(=O)N1
CP002331255948
-24.9
O=C1CCC(C(=O)NCCCNC(=O)C2=Cc3ccccc3OC2)N1