clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
Cn1cc(C(=O)NC2CC(CNC(=O)C3(C4CCCCO4)CC3)C2)nn1
CP002665580757
-20.57
O=C(NC1CC(CNC(=O)C2(C3CCCCO3)CC2)C1)c1c[nH]nn1
O=C(NCC1(Nc2ncc3c(n2)CCOC3)CCCCCC1)C1CCCC12CC2
CP000295998818
null
O=C(NCC1(Nc2ncc3c(n2)CCOC3)CCCCCC1)C1CCCC12CC2
CC(CCNC(=O)Cn1cnnc1)NC(=O)C=Cc1ccc(Cl)s1
CP003461652358
-29.32
O=C(C=Cc1cccs1)NCCCNC(=O)Cn1cnnc1
CC(=CC(=O)NCC[C@H](C)NC(=O)C(C(C)C)n1cnnc1)c1cccs1
CP001885207649
-28.56
O=C(C=Cc1cccs1)NCCCNC(=O)Cn1cnnc1
CC(=Cc1cccs1)C(=O)N(CCCNC(=O)Cn1cnnc1)C(C)C
CP002942275204
-22.81
O=C(C=Cc1cccs1)NCCCNC(=O)Cn1cnnc1
CN1CCC(=CC(=O)N[C@H]2C[C@H](CNC(=O)CC3(O)CCCOC3)C2)C1
CP002520979225
-46.37
O=C(CC1CCCOC1)NC[C@H]1C[C@H](NC(=O)C=C2CCNC2)C1
O=C(NCc1cn(C2CN(C(=O)C3=CCCO3)C2)nn1)c1cc2n(n1)CCCO2
CP000042824464
-29.06
O=C(NCc1cn(C2CN(C(=O)C3=CCCO3)C2)nn1)c1cc2n(n1)CCCO2
CCCc1cc(C(=O)N(C)C2CN(C(=O)c3conc3C3CC3)C2)c(C)o1
CP002166753024
-26.57
O=C(NC1CN(C(=O)c2conc2C2CC2)C1)c1ccoc1
NC(=O)c1cc(C(=O)NC2CN(C(=O)c3conc3C3CC3)C2)co1
CP003046995596
-25.32
O=C(NC1CN(C(=O)c2conc2C2CC2)C1)c1ccoc1
CC(=O)N1CCC[C@H]1C(=O)N(C)C(C)CNc1ccn2nccc2n1
CP002393972826
-23.02
O=C(NCCNc1ccn2nccc2n1)[C@@H]1CCCN1
CN(CCNc1ccn2nccc2n1)C(=O)[C@@H]1CCCN1CC(F)(F)F
CP002049246919
-18.75
O=C(NCCNc1ccn2nccc2n1)[C@@H]1CCCN1
CCc1nnc(C(=O)NC(C)CC2CCN(C(=O)CC3=CCCCC3)CC2)[nH]1
CP000821713732
-24.31
O=C(NCCC1CCN(C(=O)CC2=CCCCC2)CC1)c1nnc[nH]1
Cc1cc(C(=O)N2CCCC[C@@H]2CNC(=O)c2nc(C)c(C)[nH]2)no1
CP003086791726
-25.92
O=C(NC[C@H]1CCCCN1C(=O)c1ccon1)c1ncc[nH]1
CC1CCC(CN2CCCCC(NC(=O)C3CCc4nccn4C3)C2)O1
CP001742148455
-43.89
O=C(NC1CCCCN(CC2CCCO2)C1)C1CCc2nccn2C1
CC1CC(=O)NC1C(=O)NCC1CC2(CCC2)CN1C(=O)c1n[nH]c(N)n1
CP002162356991
-24.88
O=C1CCC(C(=O)NCC2CC3(CCC3)CN2C(=O)c2nc[nH]n2)N1
CC(=CC(=O)N1CC2CC(NC(=O)CCC3CC3(F)F)C2C1)c1cccs1
CP002037999715
-25.62
O=C(CCC1CC1)NC1CC2CN(C(=O)C=Cc3cccs3)CC21
CC1(CNC(=O)c2cc3ncccn3n2)CCCN(C(=O)CCOC2CC2)C1
CP000704931278
-25.1
O=C(NCC1CCCN(C(=O)CCOC2CC2)C1)c1cc2ncccn2n1
O=C(NC1C=CCN(C(=O)C2CCCCC2O)C1)c1cc(-c2ccncc2)no1
CP000047718307
-28.52
O=C(NC1C=CCN(C(=O)C2CCCCC2)C1)c1cc(-c2ccncc2)no1
CC(C)[C@H](O)C(=O)N1CC2CC(C1)N(C(=O)Cc1ccn3cncc3c1)C2
CP001694096704
-46.61
O=C(Cc1ccn2cncc2c1)N1CC2CNCC1C2
C[C@@H]1CN(C(=O)C2=COCC2)CCN1C(=O)Cn1nccc1N
CP003515877094
-22.07
O=C(Cn1cccn1)N1CCN(C(=O)C2=COCC2)CC1
CC1=C(C(=O)N2CCN(C(=O)Cn3cccn3)CC2)CCO1
CP003480465143
-18.42
O=C(Cn1cccn1)N1CCN(C(=O)C2=COCC2)CC1
CN(CC1CCN(C(=O)c2nncn2C)C1)C(=O)C1(c2cccc(C#N)c2)CC1
CP000226012080
-32.71
O=C(c1nnc[nH]1)N1CCC(CNC(=O)C2(c3ccccc3)CC2)C1
CCn1cnnc1C(=O)N1CCC(CNC(=O)C2(c3cccc(F)c3C)CC2)C1
CP000306889912
-29.22
O=C(c1nnc[nH]1)N1CCC(CNC(=O)C2(c3ccccc3)CC2)C1
Cn1nccc1C=CC(=O)N[C@H]1C[C@H]2CC[C@@H](C1)N2C(=O)Cc1cccc(F)c1
CP000143508216
null
O=C(C=Cc1ccn[nH]1)N[C@H]1C[C@H]2CC[C@@H](C1)N2C(=O)Cc1ccccc1
O=C(CC1CC1)NCC1(NC(=O)COCc2nc(C3CC3)no2)CCCCC1
CP001186461953
-21.02
O=C(CC1CC1)NCC1(NC(=O)COCc2nc(C3CC3)no2)CCCCC1
Cn1cc(CC(=O)N[C@H]2CCN(C(=O)c3cnc4ccccc4n3)C2)nn1
CP002263594981
-25.12
O=C(Cc1c[nH]nn1)N[C@H]1CCN(C(=O)c2cnc3ccccc3n2)C1
Cc1nnc(CCC(=O)NC[C@H]2CCCN2C(=O)C(=O)Nc2ncc[nH]2)o1
CP001749353805
-25.37
O=C(CCc1nnco1)NC[C@H]1CCCN1C(=O)C(=O)Nc1ncc[nH]1
O=C(C=C1CCC1)NC(CNC(=O)CNC(=O)C1CCCCC1)C1CC1
CP002750408390
-25.49
O=C(C=C1CCC1)NC(CNC(=O)CNC(=O)C1CCCCC1)C1CC1
CCc1nnsc1C(=O)NCC(C)NC(=O)C(C)=Cc1c[nH]cn1
CP003455473252
-32.75
O=C(C=Cc1c[nH]cn1)NCCNC(=O)c1cnns1
CC(C)c1nnsc1C(=O)NCC(NC(=O)C=Cc1cn(C)cn1)C(C)C
CP002090439422
-32.11
O=C(C=Cc1c[nH]cn1)NCCNC(=O)c1cnns1
CCc1nc(N)nc(N[C@H]2[C@@H]3CN(C(=O)c4cnn(CC)n4)C[C@@H]32)n1
CP002458960621
-45.86
O=C(c1cn[nH]n1)N1C[C@@H]2[C@H](C1)[C@H]2Nc1ncncn1
O=C(NC1(CNC(=O)c2ccc(NC3CC3)nc2)CCCC1)C1=COCC1
CP001934704113
-28.91
O=C(NC1(CNC(=O)c2ccc(NC3CC3)nc2)CCCC1)C1=COCC1
CCN(CC1CCN(C(=O)[C@H](C)N(C)C)CC1)c1nc(Cl)ncc1C1CC1
CP001441919076
-42.52
c1ncc(C2CC2)c(NCC2CCNCC2)n1
CCC(C)(OC)C(=O)N1CCC(F)(CNc2nc(Cl)ncc2C2CC2)CC1
CP001403625353
-31.97
c1ncc(C2CC2)c(NCC2CCNCC2)n1
CNC(=O)NCC(=O)N1CCC(F)(CNc2nc(Cl)ncc2C2CC2)CC1
CP001403565195
-28.29
c1ncc(C2CC2)c(NCC2CCNCC2)n1
CC(CC(N)=O)C(=O)N1CCC(O)(CNc2nc(Cl)ncc2C2CC2)CC1
CP001440799707
-26.57
c1ncc(C2CC2)c(NCC2CCNCC2)n1
CC(O)C(=O)N1CCC(CNc2nc(Cl)ncc2C2CC2)C(C)C1
CP002922469371
-24.94
c1ncc(C2CC2)c(NCC2CCNCC2)n1
O=C(C1CC2CCC1CC2)N1C[C@@H]2C[C@H]1CN2c1nccnc1F
CP002383382860
-20.56
O=C(C1CC2CCC1CC2)N1C[C@@H]2C[C@H]1CN2c1cnccn1
O=C(NC[C@@H]1CCCCN1C(=O)C1CC(F)(F)C1)C1CCCCS1(=O)=O
CP002663269240
-20.08
O=C(NC[C@@H]1CCCCN1C(=O)C1CCC1)C1CCCCS1(=O)=O
O=C(Cc1c[nH]c2ccc(F)cc12)NC(CNC(=O)C12CC1C2)C1CCCC1
CP000696822430
-26.12
O=C(Cc1c[nH]c2ccccc12)NC(CNC(=O)C12CC1C2)C1CCCC1
CCC(CC1CCCC1)C(=O)NCC#Cc1cn(-c2ncccc2C)nn1
CP001169393169
-31.13
O=C(CCC1CCCC1)NCC#Cc1cn(-c2ccccn2)nn1
COCC1CCOCCN1C(=O)C(=O)NC1CCCC23OCCC2CC13
CP001511069324
-21.3
O=C(NC1CCCC23OCCC2CC13)C(=O)N1CCCOCC1
COC1(C(=O)N[C@@H]2CCN(C(=O)c3ccn4ccnc4c3)C2)CCOCC1
CP002335254470
-20.96
O=C(N[C@@H]1CCN(C(=O)c2ccn3ccnc3c2)C1)C1CCOCC1
CC(C)C(O)C1(CNC2CCC(C3CCNCC3)CC2)CC1
CP002187737525
-41.5
C1CC(C2CCC(NCC3CC3)CC2)CCN1
COCC1(CNC2CCC(C3CCNCC3)CC2)CC1
CP001487619608
-40.44
C1CC(C2CCC(NCC3CC3)CC2)CCN1
CCc1cccc(OCC(=O)N2CCCC[C@@H]2CNC(=O)C[C@@H]2CC=CCC2)c1
CP000217362025
-30.09
O=C(C[C@@H]1CC=CCC1)NC[C@H]1CCCCN1C(=O)COc1ccccc1
CC1CCN(C(=O)CCC2CCC2)CCN1C(=O)c1ocnc1C(F)F
CP002509007558
-21.35
O=C(CCC1CCC1)N1CCCN(C(=O)c2cnco2)CC1
COC1CC(CCC(=O)N2CCN(C(=O)c3ocnc3C)CCC2C)C1
CP002509003734
-21.05
O=C(CCC1CCC1)N1CCCN(C(=O)c2cnco2)CC1
Cc1ncc(C(=O)N2CC(C)CN(C(=O)C(C)CC3CCC3)C(C)C2)o1
CP002514103377
null
O=C(CCC1CCC1)N1CCCN(C(=O)c2cnco2)CC1
CCc1nc(C(=O)N[C@@H](C)CNC(=O)COc2ccc3c(c2)CCC3)c[nH]1
CP002191020800
-26.54
O=C(COc1ccc2c(c1)CCC2)NCCNC(=O)c1c[nH]cn1
Cc1cc(C(=O)N2CC(CN(C)C(=O)C3(C4(O)CCN(C)CC4)CC3)C2)on1
CP000716032259
-46.89
O=C(c1ccno1)N1CC(CNC(=O)C2(C3CCNCC3)CC2)C1
CC(CC(=O)NCC1(O)CN(Cc2nc(C3CCC3)no2)C1)C(F)(F)F
CP002341960473
-26.78
C1CC(c2noc(CN3CCC3)n2)C1
CCCCC(=O)NCC1CN(Cc2nc(C3CCC3)no2)C1
CP003476772710
-22.24
C1CC(c2noc(CN3CCC3)n2)C1
CCC(C)(CC)C(=O)NC(C)C1CN(Cc2nc(C3CCC3)no2)C1
CP002419570652
-21.37
C1CC(c2noc(CN3CCC3)n2)C1
CCOC(C)C(=O)NCC1(O)CN(Cc2nc(C3CCC3)no2)C1
CP003132485997
-18.28
C1CC(c2noc(CN3CCC3)n2)C1
C=CCC1(NC(=O)C2CC(C)OC2C)CCN(C(=O)[C@H]2CCCO2)CC1
CP002594004059
-19.78
O=C(NC1CCN(C(=O)[C@H]2CCCO2)CC1)C1CCOC1
CCCC1CCCN1C(=O)CC1(n2cnnn2)CCOCC1
CP001673536365
-22.02
O=C(CC1(n2cnnn2)CCOCC1)N1CCCC1
CC1CN(C(=O)CC2(n3cnnn3)CCOCC2)CC1O
CP002294130466
-17.14
O=C(CC1(n2cnnn2)CCOCC1)N1CCCC1
CC1(C)CN(C(=O)CC2(n3cnnn3)CCOCC2)CC1CC(=O)O
CP001217078421
-6.5
O=C(CC1(n2cnnn2)CCOCC1)N1CCCC1
Cc1cc(C(=O)NC2CCN(C(=O)C3(C)CCCS3(=O)=O)CC2)sn1
CP003268518317
null
O=C(NC1CCN(C(=O)C2CCCS2(=O)=O)CC1)c1ccns1
CO[C@@H](C(=O)N[C@@H](C)C1CN(C(=O)c2cc3n(n2)CCC3)C1)c1ccccc1
CP000817722285
-30.26
O=C(Cc1ccccc1)NCC1CN(C(=O)c2cc3n(n2)CCC3)C1
CC(C)(C(=O)NCC1CN(C(=O)c2cc3n(n2)CCC3)C1)c1ccc(O)cc1
CP001105998683
-28.61
O=C(Cc1ccccc1)NCC1CN(C(=O)c2cc3n(n2)CCC3)C1
Cc1cccc(C(O)C(=O)N[C@H](C)C2CN(C(=O)c3cc4n(n3)CCC4)C2)c1
CP000793372836
-24.83
O=C(Cc1ccccc1)NCC1CN(C(=O)c2cc3n(n2)CCC3)C1
CC1C(NC(=O)C2CCn3ccnc3C2)CCCN1Cc1c(F)cccc1F
CP000553375780
-54.44
O=C(NC1CCCN(Cc2ccccc2)C1)C1CCn2ccnc2C1
CC1CCN(Cc2ccccc2F)CC1NC(=O)C1CCn2ccnc2C1
CP001582712077
-41.9
O=C(NC1CCCN(Cc2ccccc2)C1)C1CCn2ccnc2C1
CC(C)c1ccccc1CN1CC(NC(=O)C2CCn3ccnc3C2)CCC1C
CP000130175353
null
O=C(NC1CCCN(Cc2ccccc2)C1)C1CCn2ccnc2C1
CC1(C)CC2(CC2C(=O)NC2(CO)CN(C(=O)c3ccc(C(N)=O)o3)C2)C1
CP001766650398
-24.21
O=C(NC1CN(C(=O)c2ccco2)C1)C1CC12CCC2
O=C(NC12CCCCCC1N(C(=O)C=C1CCC1)CC2)c1ccn2nccc2n1
CP000152633038
null
O=C(NC12CCCCCC1N(C(=O)C=C1CCC1)CC2)c1ccn2nccc2n1
CCN(CC)CCC(=O)NC(CNc1ncnc2c1ncn2CC)C1CC1
CP001432603550
-29.57
c1nc(NCCC2CC2)c2nc[nH]c2n1
CCOC(C)C(=O)NC(CNc1nc(Cl)nc2c1ncn2C)C1CC1
CP002397629150
-29.21
c1nc(NCCC2CC2)c2nc[nH]c2n1
CCCS(=O)(=O)CC(=O)NC(CNc1ncnc2c1ncn2CC)C1CC1
CP001432464316
-26.54
c1nc(NCCC2CC2)c2nc[nH]c2n1
CC(CF)C(=O)NC(CNc1nc(Cl)nc2[nH]c(C(C)(C)O)nc12)C1CC1
CP001432684253
-26.47
c1nc(NCCC2CC2)c2nc[nH]c2n1
CCn1cnc2c(NCC(C)(NC(=O)[C@H](C)O)C3CC3)nc(Cl)nc21
CP002392699193
-26.44
c1nc(NCCC2CC2)c2nc[nH]c2n1
CCC(=O)N(C)C(CNc1nc(Cl)nc2c1ncn2C)C1CC1
CP002907626514
-26.15
c1nc(NCCC2CC2)c2nc[nH]c2n1
CCCCCC(=O)NC(CNc1nc(Cl)nc2c1ncn2C)C1CC1
CP002397626891
-25.99
c1nc(NCCC2CC2)c2nc[nH]c2n1
CCn1cnc2c(NCC(C)(NC(=O)COC)C3CC3)ncnc21
CP002384413006
-25.03
c1nc(NCCC2CC2)c2nc[nH]c2n1
Cn1cnc2c(NCC(NC(=O)CO)C3CC3)nc(Cl)nc21
CP003471238432
-25.01
c1nc(NCCC2CC2)c2nc[nH]c2n1
CSC(C)C(=O)NC(C)(CNc1nc(Cl)nc2c1ncn2C)C1CC1
CP002392621376
-23.92
c1nc(NCCC2CC2)c2nc[nH]c2n1
CN(C)C(C)(C)C(=O)NC(CNc1ncnc2[nH]c(C(F)(F)F)nc12)C1CC1
CP000466604344
-22.99
c1nc(NCCC2CC2)c2nc[nH]c2n1
NC(=O)C(=O)NC(CNc1ncnc2[nH]c(C(F)(F)F)nc12)C1CC1
CP002397661115
-22.35
c1nc(NCCC2CC2)c2nc[nH]c2n1
CC(CNc1ncnc2[nH]c(C(F)(F)F)nc12)(NC(=O)C(N)=O)C1CC1
CP002053662200
-17.46
c1nc(NCCC2CC2)c2nc[nH]c2n1
COc1ccccc1CC(=O)N1CC(C)C(CNC(=O)C23CCCN2CCC3)C1
CP000263546352
-26.5
O=C(Cc1ccccc1)N1CCC(CNC(=O)C23CCCN2CCC3)C1
CC(O)(CNC(=O)c1noc(-c2cccc(F)c2)n1)C1CC2C=CC1C2
CP001053963051
-28.1
O=C(NCCC1CC2C=CC1C2)c1noc(-c2ccccc2)n1
C=C(F)C1(CC(=O)NC(C)CC2CCN(c3nccnc3F)CC2)CCC1
CP001459473965
-21.66
O=C(CC1CCC1)NCCC1CCN(c2cnccn2)CC1
COc1ccc(C(CNC(=O)C(=O)N2CCOCC(C3CC3)C2)N(C)C)cc1
CP000476036845
-38.62
O=C(NCCc1ccccc1)C(=O)N1CCOCC(C2CC2)C1
O=C(NCCc1ccccc1Cl)C(=O)N1CCOCC(C2CC2)C1
CP002370681335
-28.08
O=C(NCCc1ccccc1)C(=O)N1CCOCC(C2CC2)C1
O=C(NCCc1ccccc1F)C(=O)N1CCOCC(C2CC2)C1
CP002370615029
-25.53
O=C(NCCc1ccccc1)C(=O)N1CCOCC(C2CC2)C1
Cc1cccc(OCCC(=O)NC[C@H]2C[C@H](NC(=O)CCc3c[nH]nn3)C2)c1
CP001081931488
-26.96
O=C(CCOc1ccccc1)NC[C@H]1C[C@H](NC(=O)CCc2c[nH]nn2)C1
Cc1nn(C)c(C)c1CC(=O)NC1CCN(C(=O)C2CCCCS2(=O)=O)C1
CP002312560286
-22.33
O=C(Cc1cn[nH]c1)NC1CCN(C(=O)C2CCCCS2(=O)=O)C1
CC1OCCC1C(=O)N1CCC[C@]1(C)CNC(=O)c1cc2c([nH]1)CCCC2
CP001765338424
-19.94
O=C(NCC1CCCN1C(=O)C1CCOC1)c1cc2c([nH]1)CCCC2
Cc1ccc(C(=O)N2CC(CO)C3(C2)CN(C(=O)C2CCN(C)CC2)C3)nn1
CP000784554703
-38.48
O=C(c1cccnn1)N1CCC2(C1)CN(C(=O)C1CCNCC1)C2
COc1ccc(C=CC(=O)NC2CCN(C(=O)C=Cc3ncc[nH]3)CC2O)cc1
CP000041584032
-47.78
O=C(C=Cc1ccccc1)NC1CCN(C(=O)C=Cc2ncc[nH]2)CC1
CC(C)(C)OC(=O)N1CCC[C@H]1CNC(=O)N1CCN2CC3(CC3)C[C@H]2C1
CP000525676644
-36.43
O=C(NC[C@@H]1CCCN1)N1CCN2CC3(CC3)C[C@H]2C1
CCOc1cccc(CCC(=O)Nc2ccc3[nH]c(C)nc3c2)c1
CP001321548740
-52.75
O=C(CCc1ccccc1)Nc1ccc2[nH]cnc2c1
COc1cccc(CC(N)C(=O)Nc2ccc3c(c2)nc(C(C)(C)C)n3C)c1
CP000404517936
-43.91
O=C(CCc1ccccc1)Nc1ccc2[nH]cnc2c1
Cc1nc2cc(NC(=O)CCc3ccc(C(C)C)cc3)ccc2n1C(CO)CO
CP000024642917
-36.71
O=C(CCc1ccccc1)Nc1ccc2[nH]cnc2c1
COc1ccc(C(C)CC(=O)Nc2ccc3c(c2)nc(C)n3C(CO)CO)cc1
CP000024642822
-30.91
O=C(CCc1ccccc1)Nc1ccc2[nH]cnc2c1
Cc1nc2cc(NC(=O)CC(C)(C(=O)O)c3ccc(Cl)cc3)ccc2n1C
CP001182463425
-14.03
O=C(CCc1ccccc1)Nc1ccc2[nH]cnc2c1
CN(CCN(C)c1ncnc2sccc12)C(=O)C1CCCN1c1ncccn1
CP000463831661
-20.09
O=C(NCCNc1ncnc2sccc12)C1CCCN1c1ncccn1
O=C(NCc1cc(-c2ccccc2F)on1)C1Cc2ccccc2O1
CP001229818254
-31.4
O=C(NCc1cc(-c2ccccc2)on1)C1Cc2ccccc2O1