clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
O=C(NCCC1CCCN(c2ccncn2)C1)c1ccns1
CP003470169827
-30.06
O=C(NCCC1CCCN(c2ccncn2)C1)c1ccns1
CSc1nccc(N2CCCC(CCNC(=O)c3cc(C)ns3)C2)n1
CP002392210298
-29.14
O=C(NCCC1CCCN(c2ccncn2)C1)c1ccns1
O=C([C@H]1C[C@@](F)(CO)C1)N1C2CCC1CN(c1cc(CC3CC3)ncn1)CC2
CP000467453471
-24.29
O=C(C1CCC1)N1C2CCC1CN(c1cc(CC3CC3)ncn1)CC2
COc1ccc2c(c1)N(C(=O)NCC1CC(C)N(Cc3ccccc3)C1)CCO2
CP000292836463
-42
O=C(NCC1CCN(Cc2ccccc2)C1)N1CCOc2ccccc21
Cc1ccc(SCC(=O)NCC2(Nc3ncnc4[nH]ccc34)CCC2)c(C)c1
CP000472230745
-37.08
O=C(CSc1ccccc1)NCC1(Nc2ncnc3[nH]ccc23)CCC1
CC(C(=O)NCc1cccc2c1CCN(C(=O)Cn1nccn1)C2)C1CC1
CP002008147331
-26.95
O=C(CC1CC1)NCc1cccc2c1CCN(C(=O)Cn1nccn1)C2
O=C(N[C@H]1CCCCN(C(=O)C2(O)CCCC2)C1)c1cncc2[nH]ccc12
CP002152463726
-25.03
O=C(N[C@H]1CCCCN(C(=O)C2CCCC2)C1)c1cncc2[nH]ccc12
CCc1onc(C)c1CNC(=O)C(=O)NC1CCC2COCCC2C1
CP001569439612
-31.68
O=C(NCc1cnoc1)C(=O)NC1CCC2COCCC2C1
Cn1ccnc1C1CCCN(C(=O)NCCC2OCCCC2(C)C)C1
CP001563307937
-27.71
O=C(NCCC1CCCCO1)N1CCCC(c2ncc[nH]2)C1
COc1cnnc(C(=O)NC2(C)CCN(C(=O)C3CC(=O)C3)CC2)c1
CP003292385123
-24.05
O=C1CC(C(=O)N2CCC(NC(=O)c3cccnn3)CC2)C1
CN(C(=O)c1cc2cn[nH]c2s1)C1CCN(C(=O)CN2CCOC2=O)CC1
CP001974975137
-23.06
O=C(NC1CCN(C(=O)CN2CCOC2=O)CC1)c1cc2cn[nH]c2s1
O=C(CCN1CCCC1)N1CC(C2CCCN(C(=O)C3CC3)C2)C1
CP003391442101
-53.46
O=C(CCN1CCCC1)N1CC(C2CCCN(C(=O)C3CC3)C2)C1
CCCC1(C(=O)N2CCCC(C3CN(C(=O)CCN4CCCC4)C3)C2)CC1
CP002136227580
-45.97
O=C(CCN1CCCC1)N1CC(C2CCCN(C(=O)C3CC3)C2)C1
COC1(CC(=O)N2CCC(CCNc3nnnn3Cc3ccccc3)C2)CC1
CP000471575113
-29.89
O=C(CC1CC1)N1CCC(CCNc2nnnn2Cc2ccccc2)C1
Cc1nc2c(C(=O)NCC3CN(C(=O)C=Cc4cc[nH]n4)CC3C)cccc2[nH]1
CP000264357789
-30.81
O=C(NCC1CCN(C(=O)C=Cc2cc[nH]n2)C1)c1cccc2[nH]cnc12
CC(CC(=O)NCCOC1CCN(c2ncc3[nH]cnc3n2)C1)c1ccccc1
CP000128625791
-28.06
O=C(CCc1ccccc1)NCCOC1CCN(c2ncc3[nH]cnc3n2)C1
CC(Cc1ccc(C#N)cc1)NC(=O)N1CCC2(CC1)CC(O)CCO2
CP001504546221
-32.61
O=C(NCCc1ccccc1)N1CCC2(CCCCO2)CC1
Cc1ccc(CCNC(=O)N2CCC3(CC2)CC(O)CCO3)cc1C#N
CP001504512417
-28.18
O=C(NCCc1ccccc1)N1CCC2(CCCCO2)CC1
O=C(NCCc1ccccc1OC(F)(F)F)N1CCC2(CCCCO2)CC1
CP001281976532
-24.37
O=C(NCCc1ccccc1)N1CCC2(CCCCO2)CC1
COC(c1ccccc1F)C(C)NC(=O)N1CCC2(CCCCO2)CC1
CP001505994406
-24.23
O=C(NCCc1ccccc1)N1CCC2(CCCCO2)CC1
CCC(Cc1ccc(Cl)cc1)NC(=O)N1CCC2(CC1)CC(O)CCO2
CP001505363882
-23.88
O=C(NCCc1ccccc1)N1CCC2(CCCCO2)CC1
COc1ccccc1C(C)(C)CNC(=O)N1CCC2(CC1)CC(O)CCO2
CP000526106513
-22.19
O=C(NCCc1ccccc1)N1CCC2(CCCCO2)CC1
CCC(CC)C(=O)NCC12CC(CO1)N(C(=O)c1cc3ncccc3s1)C2
CP002132561608
-30.98
O=C(c1cc2ncccc2s1)N1CC2CC1CO2
O=C(Cc1sc(O)nc1O)NCCN(C(=O)CCF)C1CC1
CP003489398184
-25.67
O=C(Cc1cncs1)NCCNC1CC1
CC(C)=CCN(CCNC(=O)Cc1sc(C)nc1C)C1CC1
CP003476486221
-24.02
O=C(Cc1cncs1)NCCNC1CC1
C=C(Cl)CCC(=O)N(CCNC(=O)Cc1sc(C)nc1C)C1CC1
CP003466558191
-23.44
O=C(Cc1cncs1)NCCNC1CC1
CC[S+]([O-])CC(=O)N(CCNC(=O)Cc1sc(C)nc1C)C1CC1
CP003466558141
-23.19
O=C(Cc1cncs1)NCCNC1CC1
C=C(C)CN(CCNC(=O)Cc1sc(C)nc1C)C1CC1
CP002559574711
-21.43
O=C(Cc1cncs1)NCCNC1CC1
Cc1nc(C)c(CC(=O)NCCN(C(=O)[C@H](C)O)C2CC2)s1
CP003489312441
-21.34
O=C(Cc1cncs1)NCCNC1CC1
CCCC=CC(O)C(=O)N(CCNC(=O)Cc1sc(C)nc1C)C1CC1
CP002888974194
-21.15
O=C(Cc1cncs1)NCCNC1CC1
Cc1ncc(CC(=O)NCCN(C(=O)COC(C)(C)C)C2CC2)s1
CP003466830142
-21.1
O=C(Cc1cncs1)NCCNC1CC1
Cc1ncc(CC(=O)NCCN(C(=O)CCCCCO)C2CC2)s1
CP003466830410
-21.09
O=C(Cc1cncs1)NCCNC1CC1
CC(=O)N(C)CC(=O)N(CCNC(=O)Cc1cnc(C)s1)C1CC1
CP003466830100
-20.96
O=C(Cc1cncs1)NCCNC1CC1
Cc1ncc(CC(=O)NCCN(C(=O)C(F)C(F)(F)F)C2CC2)s1
CP003466830270
-20.69
O=C(Cc1cncs1)NCCNC1CC1
CCC(CC)C(=O)N(CCNC(=O)Cc1sc(C)nc1C)C1CC1
CP003466558047
-20.44
O=C(Cc1cncs1)NCCNC1CC1
CC=CC(O)C(=O)N(CCNC(=O)Cc1sc(C)nc1C)C1CC1
CP003466558189
-19.81
O=C(Cc1cncs1)NCCNC1CC1
CO[C@H](C)C(=O)N(CCNC(=O)Cc1cnc(C)s1)C1CC1
CP003489386472
-18.77
O=C(Cc1cncs1)NCCNC1CC1
Cc1nc(C)c(CC(=O)NCCN(C(=O)CCC(C)C)C2CC2)s1
CP003466558039
-18.66
O=C(Cc1cncs1)NCCNC1CC1
COCc1nc(C)cc(NCC2CCCN(C(=O)c3cnn(CC4CC4)c3)C2)n1
CP000298170267
-26.06
O=C(c1cnn(CC2CC2)c1)N1CCCC(CNc2ccncn2)C1
Cc1cc(NCC2CCCN(C(=O)c3cnn(CC4CC4)c3)C2)nc(CO)n1
CP000501464079
-25.79
O=C(c1cnn(CC2CC2)c1)N1CCCC(CNc2ccncn2)C1
CCc1cc(C(=O)N2CCCC(N3CCN(C(=O)C=CCF)CC3=O)C2)[nH]n1
CP000625907772
-30.86
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
CSC=CC(=O)N1CCN(C2CCCN(C(=O)c3cc(C)n[nH]3)C2)C(=O)C1
CP001587148277
-30
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
CCOCCN1CCN(C2CCCN(C(=O)c3cc(C)n[nH]3)C2)C(=O)C1
CP001731359931
-28.71
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
C=CCC(=O)N1CCN(C2CCCN(C(=O)c3cc(O)nn3C)C2)C(=O)C1
CP001587190507
-26.65
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
Cn1ncc(Cl)c1C(=O)N1CCCC(N2CCN(C(=O)C(N)=O)CC2=O)C1
CP001587161759
-24.15
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
C=CCNC(=O)CN1CCN(C2CCCN(C(=O)c3ccnn3C)C2)C(=O)C1
CP000492617746
-23.62
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
Cc1n[nH]c(C(=O)N2CCCC(N3CCN(CCOC(C)C)CC3=O)C2)c1O
CP000492621093
-22.36
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
C=CC(O)C(=O)N1CCN(C2CCCN(C(=O)c3cc(O)nn3C)C2)C(=O)C1
CP000625987475
-21.49
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
Cc1cc(C(=O)N2CCCC(N3CCN(C(=O)C(C)CF)CC3=O)C2)n(C)n1
CP000625910101
-21.11
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
CC(O)C(=O)N1CCN(C2CCCN(C(=O)c3ccnn3C(C)C)C2)C(=O)C1
CP000625938280
-20.17
O=C(c1ccn[nH]1)N1CCCC(N2CCNCC2=O)C1
Cn1nccc1CC(=O)N1CCOCC2(COCCN2C(=O)c2ccco2)C1
CP001251074411
-20.48
O=C(Cc1ccn[nH]1)N1CCOCC2(COCCN2C(=O)c2ccco2)C1
CC1CCN(CC(=O)N2CCC(CNc3nccnc3F)C(C)C2)CC1
CP001926958208
-47.14
O=C(CN1CCCCC1)N1CCC(CNc2cnccn2)CC1
CC(C)(C(=O)N1CCC(O)(CNc2cncc(Cl)n2)CC1)N1CCCCC1
CP001440820932
null
O=C(CN1CCCCC1)N1CCC(CNc2cnccn2)CC1
CCCc1[nH]ccc1C(=O)N1CC(C)(NC(=O)c2[nH]nc3c2CC(C)CC3)C1
CP000922815076
-29.42
O=C(NC1CN(C(=O)c2cc[nH]c2)C1)c1[nH]nc2c1CCCC2
O=C(NC1CC2(CCN(C(=O)C3=CCCC3)C2)C1)[C@@H]1CCOC1
CP003512593469
-19.19
O=C(NC1CC2(CCN(C(=O)C3=CCCC3)C2)C1)[C@@H]1CCOC1
Cc1noc(C(=O)N2CCC[C@@H]2CCNC(=O)c2cn[nH]c2-c2ccn(C)n2)n1
CP000229090897
-22.03
O=C(NCC[C@H]1CCCN1C(=O)c1ncno1)c1cn[nH]c1-c1cc[nH]n1
CC1CC(C(=O)N2CCCC(C)(CNC(=O)Cn3cnc(C(N)=O)n3)C2)CO1
CP000705266180
-19.47
O=C(Cn1cncn1)NCC1CCCN(C(=O)C2CCOC2)C1
CCC(C(=O)N(C)CC1CCCN(C(=O)C2COC(C)C2)C1)n1cncn1
CP002241872369
-18.97
O=C(Cn1cncn1)NCC1CCCN(C(=O)C2CCOC2)C1
O=C(NC1CCCN(C(=O)c2cc3ccccc3o2)CC1)c1cn[nH]c(=O)c1
CP001108822982
-25.46
O=C(NC1CCCN(C(=O)c2cc3ccccc3o2)CC1)c1cn[nH]c(=O)c1
O=C(CCc1ccco1)NC1CN(C(=O)C2(C3CCCO3)CC2)C1
CP001899757030
-22.11
O=C(CCc1ccco1)NC1CN(C(=O)C2(C3CCCO3)CC2)C1
CC1=NN(C)C(=O)C1CC(=O)NC1(C)CN(C(=O)CCOc2ccccc2)C1
CP000924330408
-24.32
O=C(CC1C=NNC1=O)NC1CN(C(=O)CCOc2ccccc2)C1
CCC(=CC(=O)N1CCC2(CCCN2C(=O)c2ncnc3nc[nH]c23)CC1)CC
CP000134568239
-26.62
O=C(c1ncnc2nc[nH]c12)N1CCCC12CCNCC2
CC(Cn1cc(C2CCN(C)CC2)nn1)NC(=O)C1(C)CCCCCC1
CP001271923824
-45.5
O=C(NCCn1cc(C2CCNCC2)nn1)C1CCCCCC1
Cc1cncc(CC(=O)NCC2CCCN2C(=O)Cc2cncnc2)c1
CP002883307349
-25.31
O=C(Cc1cccnc1)NCC1CCCN1C(=O)Cc1cncnc1
CC1(C)CC(CNC(=O)Cc2cccnc2)N(C(=O)Cc2cncnc2)C1
CP001753585495
-22.48
O=C(Cc1cccnc1)NCC1CCCN1C(=O)Cc1cncnc1
C[C@@]1(CNC(=O)Cc2cccnc2)CCCN1C(=O)Cc1c(O)ncnc1O
CP000583499100
-19.41
O=C(Cc1cccnc1)NCC1CCCN1C(=O)Cc1cncnc1
C=C1CCC(C(=O)N2CCC(NC(=O)c3coc(CO)c3)C3(CCC3)C2)CC1
CP000796839335
-22.61
C=C1CCC(C(=O)N2CCC(NC(=O)c3ccoc3)C3(CCC3)C2)CC1
Cc1cc(CC(=O)NCC2=CCN(C(=O)c3nc[nH]c3C)CC2)ccn1
CP002755974345
-20.61
O=C(Cc1ccncc1)NCC1=CCN(C(=O)c2c[nH]cn2)CC1
Cn1nnc2c(C(=O)N[C@H]3C[C@@H](CNC(=O)COC4CCCC4)C3)ccnc21
CP000647174097
-23.27
O=C(COC1CCCC1)NC[C@H]1C[C@@H](NC(=O)c2ccnc3[nH]nnc23)C1
O=C(C1CC12CC(O)C2)N1CCCC(CCNc2nc3cccc(F)c3o2)C1
CP000511609578
-25.49
O=C(C1CC12CCC2)N1CCCC(CCNc2nc3ccccc3o2)C1
CCCc1ccc(C(=O)N2CCCC(CCNC(=O)C3CC34CC(O)C4)C2)[nH]1
CP000970160515
-24.24
O=C(NCCC1CCCN(C(=O)c2ccc[nH]2)C1)C1CC12CCC2
COCc1ccc(C(=O)N2CCCC(CCNC(=O)C3CC34CC(O)C4)C2)[nH]1
CP000970160296
-22.99
O=C(NCCC1CCCN(C(=O)c2ccc[nH]2)C1)C1CC12CCC2
CCCc1ncoc1C(=O)N[C@H]1C[C@@H](NC(=O)C2=C(Cl)CC2)C1
CP003364970605
-25.79
O=C(N[C@H]1C[C@@H](NC(=O)c2cnco2)C1)C1=CCC1
CCc1nc(C)c(C(=O)N[C@H]2C[C@@H](NC(=O)C3=C(Cl)CC3)C2)o1
CP003364643203
-21.22
O=C(N[C@H]1C[C@@H](NC(=O)c2cnco2)C1)C1=CCC1
Cc1ncc(C(=O)N(C)CC(C)Nc2nnnn2C)o1
CP001489550810
-28.92
O=C(NCCNc1nnn[nH]1)c1cnco1
CCCN(CCNC(=O)c1cnco1)c1nnnn1C
CP001489159850
-22.78
O=C(NCCNc1nnn[nH]1)c1cnco1
CCC(CC)(CNc1nnnn1C)NC(=O)c1cnc(C)o1
CP003474980657
-21.25
O=C(NCCNc1nnn[nH]1)c1cnco1
CCn1cc(C(=O)N2CC3(CCN(C(=O)c4ccc(=O)n(C)c4)CC3)C2)cn1
CP000914605699
-23.76
O=C(c1ccc(=O)[nH]c1)N1CCC2(CC1)CN(C(=O)c1cn[nH]c1)C2
Cc1cc(C(=O)NC(C)CN(C)Cc2ncc(C3CC3)o2)oc1C
CP003131385547
-24.03
O=C(NCCNCc1ncc(C2CC2)o1)c1ccco1
CC1(C)COC1C(=O)N1CCCC1CNC(=O)C1CCC2CC2C1
CP003464406094
-22.92
O=C(NCC1CCCN1C(=O)C1CCO1)C1CCC2CC2C1
CC1(C)COC1C(=O)N1CCCC1C(C)(C)NC(=O)C1CCC2C(C1)C2(F)F
CP000732935686
-16.1
O=C(NCC1CCCN1C(=O)C1CCO1)C1CCC2CC2C1
C=CCCC(=O)N1CCC(C2(NC(=O)C3(C#N)CC=CC3)CC2)CC1
CP003229945363
-24.01
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
CON=CC(=O)N1CCC(C2(NC(=O)C3CC=CC3)CC2)CC1
CP003500507952
-23.68
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
COCC1(C(=O)NC2(C3CCN(C(=O)CCC(N)=O)CC3)CC2)CC=CC1
CP002165003271
-23.01
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
CC=C(CC)C(=O)N1CCC(C2(NC(=O)C3(COC)CC=CC3)CC2)CC1
CP002164987660
-22.22
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
CCC(C(=O)OC)C(=O)N1CCC(O)(C2(NC(=O)C3CC=CC3)CC2)CC1
CP001709257133
-21.53
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
CC=C(CC)C(=O)N1CCC(C2(NC(=O)C3CC=CC3)CC2)CC1
CP003378116927
-20.62
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
O=C(NC1(C2CCN(C(=O)CCCCO)CC2)CC1)C1CC=CC1
CP003378116956
-19.7
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
C=CCC1(C(=O)NC2(C3CCN(C(=O)CCCC(C)O)CC3)CC2)CC=CC1
CP000836103591
-19.69
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
CCC(C)(C)NC(C)C(=O)N1CCC(C2(NC(=O)C3CC=CC3)CC2)CC1
CP001639677722
-19.22
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
CN(C)C(=O)CCC(=O)N1CCC(C2(NC(=O)C3(C)CC=CC3)CC2)CC1
CP002165004672
-18.73
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
CCC(C(=O)N1CCC(C2(NC(=O)C3(C)CC=CC3)CC2)CC1)N(CC)CC
CP000836005271
-18.56
O=C(NC1(C2CCNCC2)CC1)C1CC=CC1
Cn1cc(CCC(=O)NC2CCC(CNC(=O)C3CC(=O)C3)C2)nn1
CP003072093427
-22.11
O=C1CC(C(=O)NCC2CCC(NC(=O)CCc3c[nH]nn3)C2)C1
O=C(c1cc2cccnc2[nH]1)N1CCC(NC(=O)C23CC2C3)C2(CCC2)C1
CP001810016718
-23.3
O=C(c1cc2cccnc2[nH]1)N1CCC(NC(=O)C23CC2C3)C2(CCC2)C1
CCC1(C)C=C(C(=O)NC(C)CCCNC(=O)c2cccc3oc(C)nc23)C1
CP001085846191
-23.83
O=C(NCCCCNC(=O)c1cccc2ocnc12)C1=CCC1
CCC1(C)CCC(C(=O)N2CCC(C)N(C(=O)C=Cc3ccccc3)CC2)O1
CP000760745885
-28.89
O=C(C=Cc1ccccc1)N1CCCN(C(=O)C2CCCO2)CC1
Cc1cc(C)c(C=CC(=O)N2CCN(C(=O)C3CCCO3)CC(O)C2)cc1C
CP000925622220
-27.06
O=C(C=Cc1ccccc1)N1CCCN(C(=O)C2CCCO2)CC1
COc1ccccc1C(C)=CC(=O)N1CCC(C)N(C(=O)C2CCCO2)CC1
CP000760174885
-23.47
O=C(C=Cc1ccccc1)N1CCCN(C(=O)C2CCCO2)CC1
CN(CC1CCCN(c2nc3ccccc3c(=O)[nH]2)C1)C(=O)C=CC1CCCC1
CP000281241412
-30.59
O=C(C=CC1CCCC1)NCC1CCCN(c2nc3ccccc3c(=O)[nH]2)C1
Cc1ccnc2nc(C(=O)NC[C@@]3(C)CCCN3C(=O)C3CC4(CC4)C3)nn12
CP000763763817
-27.36
O=C(NCC1CCCN1C(=O)C1CC2(CC2)C1)c1nc2ncccn2n1