ID
stringlengths
13
17
question
stringlengths
88
1.13k
answer
stringlengths
6
156
reference_sequence
stringlengths
4.1k
4.1k
variant_sequence
stringlengths
4.1k
4.1k
Task1_train_20500
Chromosome 15 houses a mutation in gene SLC12A6 (solute carrier family 12 member 6). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Charcot-Marie-Tooth disease, axonal, IIa 2II
ATTTCCCAGTCTTGTTTCATGTATTATTCTAGATTTTTTGTCTTGTTTTGCTGGAATATCTCAAAGAAAATACCATGCATTATGACCGTGTACTAATCAAAAAAGAGGAGAAGCCCCAAAGGTGAACCTGAGACAAAATGGAATTTCCCAAATTGAGATATAACCAGAATGTCACCTTTAGAAATTTTATGCCCCTAAAAAGGACCTTCAGCTGTATTACAGTCCCTAGATAAGCAGATTAAAAGTTTAAGATGGAATCTACTTCTGCCATCATGCAGCATAGCATAGAAGAAATACTGAATGGGGAGTCAGGAAATCACAGTTCATCTTCTTGCTCTGCCATTAATTAACTTTGAGGTAAGTCATTAAACCTACTGGAACTGTCTTTTTGTCTTGAAAAATCTTTTTTTCTGTAATCTGGTTAAATCAACATAGAACCGATGAGTTTGATCCTCAGATAATCCAGATGACTCTTCAAGATAATTCTGTAACAAGACTACAAATAACACTGAGTGCCAGCTAGTCCCTATGCCACTAGTCAAAGGGAAAAGTGAGCCTGTGAGTCACAGATGTGCACAAATCCATTACTACTTCAAAAAACATACTTTAAAGTATTCGCACTAGGGAGTTGAAGGAGGTGGTGAATGATGAGAGAGTACTTAATGGGTACAAAGTACATTATTTGGGTAATGGATAAAAGCCCTGACCTAGGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACGTCGGGAGGCCAAGGTGGGCCTTATAAAGGTTGCTGGCAATAACTACACTGTCTGCAAAGCCCTTTATGAATAGTTCAAAATGTGTATAATAAAAAAAGATTATGTACAATTATCAGGGAGAAAAAAATCTAATATCTGAACCTAAATGATGGTTACAGCTACTAGTTCTATGCTTAGGACATAAGAAAGAGGATGAACGGGACATAGTTTGCTGGTAGGCTTCCTGCCTAGATGAGGAAGGAAGTCTAACTGGGCTTATCTGAGAGGGAAAATCTCAGAGAGACTCTATGAAATTCTGACTTAAAATTATCACACCACCAGATATTTTCAATTACTACCCAATAAGGATGGCTAGGCAGAGAGACAGACACGTACGGGAAGTGTGGAGGAGCAAAAGAAGACTTGATGGCTCCAGCATAGATGGCCAAGATGGACACAATGACACAGGCCAGGAAAAGTGAGGCAAACTTGTTCACATAGCGTACGCCGATAAATACCACTAATACCATAAGGACCAAGAAAGCTGTGCCGTAGACACGCATGTTATTTAGCATGGCTGCTGATTCCTTGAGTGCGTCATCACTGTGAAAGATGGCAGCTCGGGGGACGATATAGACCTGTTAGGTAAAAATAAAGGAGAAAATTAGGTTATTTCAAAATAATTAAGTAAAAAGGCTGTATTCGTTTGCATTTACTTTCACAAAAGAAAGCAAAGCTGAGAGAGAAAATGACTGGGGAATTAGCCTAGTTTCTAATAGGATCTGAAATGCCTTCAGAAATGGGATGTCATGGATTTTTTTTTTTTTTTTGGTCTACATGCTGTTCTGAATAACTACATTTCCAAATGGAAAGAAAGGAAAGGAACAAATTATTAATTTTATTCATAGGGTTATATAAAGTAATTATAATGATGATCTTTAACCCTGACTCTACTATCACTACTTTAAATAGTAAACAATATGTCTCAGTGAAGAGAGATATGAGAAGCATTTTATTTCATAGGGATGAAGATATCAAAAAAGATAAACTTTATTTTACTTTTTCCCCATTGGACTTGAACCTCTTGGATGAGGTGGCAGAGTGGTGGCAATCAGGTAGAAAGGAAGGGACAGGCAGGCAAACAGAATTTCAACCTTTCCACCTCATATTCATGTAAGAGGCCAACTGACGTTGGCAGTCAATCACCTGATTTATTCCCACAGCTGATCTCTCAGAAGCTTTCATAGCAAAGAATAAACCTAAATCAATATTTCTTCTATATTATAGACCACAATGAAGTCATTACTTACCAGAAAGATTTCAATGGCACCAAGGATGTACATGGCTGCTGCAAATGTGGTACCAAGATAAAAGCAGAGGCCAACAGCCCCACCAAACTCTGGGCCCAGTGCCCGGGAAATCATAAAGTATGAGCCCCCAGCTAAAAGACAAAACAGAAGGTGAATAGAAGAAAGAGTGTGTATTAGCAAGAGGAATATGAATAAAACAGAAATAAGAAAAAATATATACATAAAGGTTAAATGTTTCAGGCTTCTGCAAACCCTCAATGTGATAAAAAGATGTGCTAGTGGGAAGTAAAAGGTGAAAGTGTTATTGTGGGATATACTGCACAACTAATGTAATGAGCCATATGAAGCAATAGTTTGCCAGCATTTACTTAGAAAAAAATTAGAGAATATTTACTATGACATGAGACAGCCCAATAAAATATATTCTGGCTGGGTGTGGAGGTTCACGCCTCTAATGGTAGCACTTTGGGAGGATGAGGCGAGAGGATTGCTTGAGGCCAGGAGTTTGAGACCAAACTGGGTAACATAGTAAAATGTCACCTCTGTAAAAAAAAAAAAATAGCCAGGCATAGTGGTGTACACCTCTAGTTCCAGCTACTCAGGAGGCTGAAGTGGGAAAGCAGCTTGAGCCTAGGAGTTGGAGGCTGTGTGAGCTATGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTATAAAAAAATATATATTCCAACTAATAAAAGCTAAGAATGTGACTGAAATTAATGCATTCTAGTTTAAAAAATAAAGAGATTTTAAAGACGGCATCTTAAAGTCAAGTAGTATTATGTCTACGTCCTATAGACCATTACTCTGTTGTAGCACAGAACAGACCAAATAGTATTCTATTCTTCAGAAGTTTGCACCTCTAGCTTTATAGCATAAACACAGAGTCAACACTGATAAATCCTGAAATACAACCTTGACCTACTAACCTGGCACCACTCCATTAGTGGCAATGGCACTCATGGAGATAGCAGTCAACATTGTCTGCAGAGAAAAGGAAAGGAGAGGATTGTTACTGTGTAAAGATGACATTTCTATACTACTTCTCCATTTGTGTTCCAAGAGCACTTGGCAAACATTTAACTCTACCTACTTTTATGGACAGTCATACCTAATGGTATGGAAATAAGATGATATGGTCCAATTCATTGCGCTAGTCATACCACTAATATCTGGAGGATTCTGTCAAAATGCTCCCACATCAGTAGGTCAGGTGCTATTAAGAACTGCTAATCTCACTCTGGATTTCCTAGTTACACAGGAAATAGAGCATAGTATACTCAAAAGGAAGAACTAGAGAAATAACTCAGAAAATAGGTTAGAACCTGACTAAAGACTAAATACAATATCAAGAACAATGTTCAGTAAGAAAGGGAATCACTGAAGGCTTCTGAGCACACAGGAACCGCATTTTAAAAATATTACCCGGTAGCACAGTATAGAATGCGCTGCAGATAGGAGTAGCTGGAGGCCGAGTGATTGGTTAGCAGGCTACCATAGTAGTTCAGTGAGAGGTAAAAACTATAGTGGTGGTAGTGTGAATAAAAAGGGCTGAGTGTAAAAGATTTCAGAGAATAGATTAGCGTTGGTAGCTGATTAGATGTGAAAAGCAATTAAGAAGCCAAACACAGCCTTGAGGTTTTAAGCCTGAGACTAAAAAAAGGTGGTACCATGAACATTTTAAGTTATTAAAAATATGAACTGTGCCTGCTTAACCTGTTTTGCTCATCAGCTGGGGATAATATACAGGTAGGGTATAAAGGTCATAGTGATAAAAAAGGACAGTAGAAAACTATAAAATTCATAGGTGTGTCTGGGATACATAATGAGAAGTTTAAATTAAAGGAAGATAAAAATGTTCTCAGTAGAGAGAAGACCTGGAAAGAACATCTAAATTTCTAAGGAAGGGATAAGGGAAGAAACTTCAAAACCAAATAAAAAAACCAAATACCCCTCACATCCGCAATAACCTGTCTTGTTTCTCAATATATACTGGAGTGATACATCACATTTTCTAACAC
ATTTCCCAGTCTTGTTTCATGTATTATTCTAGATTTTTTGTCTTGTTTTGCTGGAATATCTCAAAGAAAATACCATGCATTATGACCGTGTACTAATCAAAAAAGAGGAGAAGCCCCAAAGGTGAACCTGAGACAAAATGGAATTTCCCAAATTGAGATATAACCAGAATGTCACCTTTAGAAATTTTATGCCCCTAAAAAGGACCTTCAGCTGTATTACAGTCCCTAGATAAGCAGATTAAAAGTTTAAGATGGAATCTACTTCTGCCATCATGCAGCATAGCATAGAAGAAATACTGAATGGGGAGTCAGGAAATCACAGTTCATCTTCTTGCTCTGCCATTAATTAACTTTGAGGTAAGTCATTAAACCTACTGGAACTGTCTTTTTGTCTTGAAAAATCTTTTTTTCTGTAATCTGGTTAAATCAACATAGAACCGATGAGTTTGATCCTCAGATAATCCAGATGACTCTTCAAGATAATTCTGTAACAAGACTACAAATAACACTGAGTGCCAGCTAGTCCCTATGCCACTAGTCAAAGGGAAAAGTGAGCCTGTGAGTCACAGATGTGCACAAATCCATTACTACTTCAAAAAACATACTTTAAAGTATTCGCACTAGGGAGTTGAAGGAGGTGGTGAATGATGAGAGAGTACTTAATGGGTACAAAGTACATTATTTGGGTAATGGATAAAAGCCCTGACCTAGGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACGTCGGGAGGCCAAGGTGGGCCTTATAAAGGTTGCTGGCAATAACTACACTGTCTGCAAAGCCCTTTATGAATAGTTCAAAATGTGTATAATAAAAAAAGATTATGTACAATTATCAGGGAGAAAAAAATCTAATATCTGAACCTAAATGATGGTTACAGCTACTAGTTCTATGCTTAGGACATAAGAAAGAGGATGAACGGGACATAGTTTGCTGGTAGGCTTCCTGCCTAGATGAGGAAGGAAGTCTAACTGGGCTTATCTGAGAGGGAAAATCTCAGAGAGACTCTATGAAATTCTGACTTAAAATTATCACACCACCAGATATTTTCAATTACTACCCAATAAGGATGGCTAGGCAGAGAGACAGACACGTACGGGAAGTGTGGAGGAGCAAAAGAAGACTTGATGGCTCCAGCATAGATGGCCAAGATGGACACAATGACACAGGCCAGGAAAAGTGAGGCAAACTTGTTCACATAGCGTACGCCGATAAATACCACTAATACCATAAGGACCAAGAAAGCTGTGCCGTAGACACGCATGTTATTTAGCATGGCTGCTGATTCCTTGAGTGCGTCATCACTGTGAAAGATGGCAGCTCGGGGGACGATATAGACCTGTTAGGTAAAAATAAAGGAGAAAATTAGGTTATTTCAAAATAATTAAGTAAAAAGGCTGTATTCGTTTGCATTTACTTTCACAAAAGAAAGCAAAGCTGAGAGAGAAAATGACTGGGGAATTAGCCTAGTTTCTAATAGGATCTGAAATGCCTTCAGAAATGGGATGTCATGGATTTTTTTTTTTTTTTTGGTCTACATGCTGTTCTGAATAACTACATTTCCAAATGGAAAGAAAGGAAAGGAACAAATTATTAATTTTATTCATAGGGTTATATAAAGTAATTATAATGATGATCTTTAACCCTGACTCTACTATCACTACTTTAAATAGTAAACAATATGTCTCAGTGAAGAGAGATATGAGAAGCATTTTATTTCATAGGGATGAAGATATCAAAAAAGATAAACTTTATTTTACTTTTTCCCCATTGGACTTGAACCTCTTGGATGAGGTGGCAGAGTGGTGGCAATCAGGTAGAAAGGAAGGGACAGGCAGGCAAACAGAATTTCAACCTTTCCACCTCATATTCATGTAAGAGGCCAACTGACGTTGGCAGTCAATCACCTGATTTATTCCCACAGCTGATCTCTCAGAAGCTTTCATAGCAAAGAATAAACCTAAATCAATATTTCTTCTATATTATAGACCACAATGAAGTCATTACTTACCAGAAAGATTTTAATGGCACCAAGGATGTACATGGCTGCTGCAAATGTGGTACCAAGATAAAAGCAGAGGCCAACAGCCCCACCAAACTCTGGGCCCAGTGCCCGGGAAATCATAAAGTATGAGCCCCCAGCTAAAAGACAAAACAGAAGGTGAATAGAAGAAAGAGTGTGTATTAGCAAGAGGAATATGAATAAAACAGAAATAAGAAAAAATATATACATAAAGGTTAAATGTTTCAGGCTTCTGCAAACCCTCAATGTGATAAAAAGATGTGCTAGTGGGAAGTAAAAGGTGAAAGTGTTATTGTGGGATATACTGCACAACTAATGTAATGAGCCATATGAAGCAATAGTTTGCCAGCATTTACTTAGAAAAAAATTAGAGAATATTTACTATGACATGAGACAGCCCAATAAAATATATTCTGGCTGGGTGTGGAGGTTCACGCCTCTAATGGTAGCACTTTGGGAGGATGAGGCGAGAGGATTGCTTGAGGCCAGGAGTTTGAGACCAAACTGGGTAACATAGTAAAATGTCACCTCTGTAAAAAAAAAAAAATAGCCAGGCATAGTGGTGTACACCTCTAGTTCCAGCTACTCAGGAGGCTGAAGTGGGAAAGCAGCTTGAGCCTAGGAGTTGGAGGCTGTGTGAGCTATGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTATAAAAAAATATATATTCCAACTAATAAAAGCTAAGAATGTGACTGAAATTAATGCATTCTAGTTTAAAAAATAAAGAGATTTTAAAGACGGCATCTTAAAGTCAAGTAGTATTATGTCTACGTCCTATAGACCATTACTCTGTTGTAGCACAGAACAGACCAAATAGTATTCTATTCTTCAGAAGTTTGCACCTCTAGCTTTATAGCATAAACACAGAGTCAACACTGATAAATCCTGAAATACAACCTTGACCTACTAACCTGGCACCACTCCATTAGTGGCAATGGCACTCATGGAGATAGCAGTCAACATTGTCTGCAGAGAAAAGGAAAGGAGAGGATTGTTACTGTGTAAAGATGACATTTCTATACTACTTCTCCATTTGTGTTCCAAGAGCACTTGGCAAACATTTAACTCTACCTACTTTTATGGACAGTCATACCTAATGGTATGGAAATAAGATGATATGGTCCAATTCATTGCGCTAGTCATACCACTAATATCTGGAGGATTCTGTCAAAATGCTCCCACATCAGTAGGTCAGGTGCTATTAAGAACTGCTAATCTCACTCTGGATTTCCTAGTTACACAGGAAATAGAGCATAGTATACTCAAAAGGAAGAACTAGAGAAATAACTCAGAAAATAGGTTAGAACCTGACTAAAGACTAAATACAATATCAAGAACAATGTTCAGTAAGAAAGGGAATCACTGAAGGCTTCTGAGCACACAGGAACCGCATTTTAAAAATATTACCCGGTAGCACAGTATAGAATGCGCTGCAGATAGGAGTAGCTGGAGGCCGAGTGATTGGTTAGCAGGCTACCATAGTAGTTCAGTGAGAGGTAAAAACTATAGTGGTGGTAGTGTGAATAAAAAGGGCTGAGTGTAAAAGATTTCAGAGAATAGATTAGCGTTGGTAGCTGATTAGATGTGAAAAGCAATTAAGAAGCCAAACACAGCCTTGAGGTTTTAAGCCTGAGACTAAAAAAAGGTGGTACCATGAACATTTTAAGTTATTAAAAATATGAACTGTGCCTGCTTAACCTGTTTTGCTCATCAGCTGGGGATAATATACAGGTAGGGTATAAAGGTCATAGTGATAAAAAAGGACAGTAGAAAACTATAAAATTCATAGGTGTGTCTGGGATACATAATGAGAAGTTTAAATTAAAGGAAGATAAAAATGTTCTCAGTAGAGAGAAGACCTGGAAAGAACATCTAAATTTCTAAGGAAGGGATAAGGGAAGAAACTTCAAAACCAAATAAAAAAACCAAATACCCCTCACATCCGCAATAACCTGTCTTGTTTCTCAATATATACTGGAGTGATACATCACATTTTCTAACAC
Task1_train_20501
Here’s a variant in LOC129390683, SLC12A6 (MPRA-validated peak2292 silencer| solute carrier family 12 member 6) located on Chromosome 15. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Inborn genetic diseases
GAGACAGCCCAATAAAATATATTCTGGCTGGGTGTGGAGGTTCACGCCTCTAATGGTAGCACTTTGGGAGGATGAGGCGAGAGGATTGCTTGAGGCCAGGAGTTTGAGACCAAACTGGGTAACATAGTAAAATGTCACCTCTGTAAAAAAAAAAAAATAGCCAGGCATAGTGGTGTACACCTCTAGTTCCAGCTACTCAGGAGGCTGAAGTGGGAAAGCAGCTTGAGCCTAGGAGTTGGAGGCTGTGTGAGCTATGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTATAAAAAAATATATATTCCAACTAATAAAAGCTAAGAATGTGACTGAAATTAATGCATTCTAGTTTAAAAAATAAAGAGATTTTAAAGACGGCATCTTAAAGTCAAGTAGTATTATGTCTACGTCCTATAGACCATTACTCTGTTGTAGCACAGAACAGACCAAATAGTATTCTATTCTTCAGAAGTTTGCACCTCTAGCTTTATAGCATAAACACAGAGTCAACACTGATAAATCCTGAAATACAACCTTGACCTACTAACCTGGCACCACTCCATTAGTGGCAATGGCACTCATGGAGATAGCAGTCAACATTGTCTGCAGAGAAAAGGAAAGGAGAGGATTGTTACTGTGTAAAGATGACATTTCTATACTACTTCTCCATTTGTGTTCCAAGAGCACTTGGCAAACATTTAACTCTACCTACTTTTATGGACAGTCATACCTAATGGTATGGAAATAAGATGATATGGTCCAATTCATTGCGCTAGTCATACCACTAATATCTGGAGGATTCTGTCAAAATGCTCCCACATCAGTAGGTCAGGTGCTATTAAGAACTGCTAATCTCACTCTGGATTTCCTAGTTACACAGGAAATAGAGCATAGTATACTCAAAAGGAAGAACTAGAGAAATAACTCAGAAAATAGGTTAGAACCTGACTAAAGACTAAATACAATATCAAGAACAATGTTCAGTAAGAAAGGGAATCACTGAAGGCTTCTGAGCACACAGGAACCGCATTTTAAAAATATTACCCGGTAGCACAGTATAGAATGCGCTGCAGATAGGAGTAGCTGGAGGCCGAGTGATTGGTTAGCAGGCTACCATAGTAGTTCAGTGAGAGGTAAAAACTATAGTGGTGGTAGTGTGAATAAAAAGGGCTGAGTGTAAAAGATTTCAGAGAATAGATTAGCGTTGGTAGCTGATTAGATGTGAAAAGCAATTAAGAAGCCAAACACAGCCTTGAGGTTTTAAGCCTGAGACTAAAAAAAGGTGGTACCATGAACATTTTAAGTTATTAAAAATATGAACTGTGCCTGCTTAACCTGTTTTGCTCATCAGCTGGGGATAATATACAGGTAGGGTATAAAGGTCATAGTGATAAAAAAGGACAGTAGAAAACTATAAAATTCATAGGTGTGTCTGGGATACATAATGAGAAGTTTAAATTAAAGGAAGATAAAAATGTTCTCAGTAGAGAGAAGACCTGGAAAGAACATCTAAATTTCTAAGGAAGGGATAAGGGAAGAAACTTCAAAACCAAATAAAAAAACCAAATACCCCTCACATCCGCAATAACCTGTCTTGTTTCTCAATATATACTGGAGTGATACATCACATTTTCTAACACATTTTCTGTCACAACTTTGGTGCTATCAAGCTCAAATAGTTTGGATTCTGAATTCTCTGAAGACAGGAACTTTATCTTCCATTTTCAGTTGAAGTCTTGCTTTGTAATTTCTAGTACATCATATAATAGATAGCAAGCAGTGACTAACAGGCACTGAATAACTGAAAATCCTTTAGATTTTAATATCAGAATAATTTCTTCTGTTGAGATCATGAGTCCTTCCCTAAGTATTCTTTGTTTTATTCCCAAAGAGGTCATGTGCATCTGCTCTTGAGAACTTGCAACGTTCAGGTGATCTCTAGGAGCCAGTGCAGTACTTACACAGCAGCAGCAGATAAGGACAATTGCAAAAGCCTGAAGAACTCCAGCTGTGCCCACCACCCATGTAAGGCGTAAAAAAAGGATCACTCCAAAAATATTTTGTAGACATGGGAGGTAGACACCCATGAAGGTACCCATTTGGGGGGTCTAGAAAGAAAGACATTGATAAAAAATCACACAGTTATCCTAAAGAGAGGTTTTTATTCTTTTATGTAATAACTTGCTCCCTAACTACCATATTAACCTCCAAGCAGAAATCATAAGTTTAATCAATACCTTCAAAAGGGCACATATAAAATCTCCATCTTTCAAGTGTTTATCACCATACTTTTATTATTCCTAAAGCTATATATTTTAACTTTACAAAGGTTCCTGCATGTGTTTATTATACATAGGCATTTGGCCACAAATAAACTTTTATGTGCACCCACAACAATTTAAAATTTTGTTTTTCAAAGCTGTTGGCTTTTTTCATTTAAAAACAATAAGGACTTGATGGAATTTCTTCAGAATTTGGCATAAATTCTTCACAGTAGTTAGTAAATAAATTAGATGGCAAAATGAAGATCTGAGGGCCGTTTTATCCCTTTTTGAAAGGGCTGAACAACCAGAATGGTAAACTGAATGTCTTATATTTTCATTTTGAGACAAACTGATGTTTGGTGTTTAAAAAACCCAACAACTTCACAACAGACAGATGGCATCAGCAGATGGGTATGGACACTCTTCTCTTGAAAAGCTATTCCCTCTCCCTGAATGCTCTTTTCCCACATAGCTCACTCCCTCCCATCAGCTAGATCTCTCCTCAAATATCACCTTGTCAGAAAGGCTTTCCCTGTCCAACCTATGTAAGTAGCAACGCCCTCCACTCTGGATCCCTTGCCAATTTCAGTCTCTCTACTCTGCTTAATTTTTTGCTCGGGAATTTATCAACACTTAATATGTTATATACTTTGGCAGTTAAAACAGCTTAAGGACTGTATCCCCACATCAGAATTTAGACTGCATCATATGTTTTCTTTGTGCTATGACGCTGGTGCCCAGAACAGTTCCAGGCACCTCTCAAGCATTTAATAAATAGCTGCTGAACACAGAATGGTGCCTTAGGTATTTCCTTCTTTCTTATATACAGGGCTCTTTCTATGTATTCCTTGTTATTCTGAGGCCTCACCTTGGTGGGCTTCTTTTTCCCTTCAGTGATGTTTTCTGCCTCTTCATGTTCCTTTGCTCCTTGAGTCAGATTAGTGTAATTGGCCATGCGGTTGAGGAGGGAAGACACCTTCGGTCTGGTGTCCATTTCTTCCTATAAAGCCAGTGACATGGAAGAAATGAGCTACAAAGAACACTGAACATAAGTATCAAAATAATCTTGCTACCAGAAAACTTCAAATTAAATGAAAAAATATTTCACAGGTAGGCCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGCTGGATCACCTGAGGCTGGGAGTTTGAGACCAGCCTGGCCAAGATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATAAGCTGGGTGTGGTGGCACGTGCCTGTAATCCCAGCTACACGGGAGGCTGAGGCGGGAGAATCAGCTTGAACCCAGGAGGCAGAAGTTGCAGTGAGCCGAGATCGCGCCACTGCGCTCCAGCCTGGGCAACAGAGGGAGACTCCATCTCAAAAAAAAAAAAAAAATTGGTACATTGAGTTGGGCATGGTGGCTCACACCTGCTAACCCAATGCTATGGGAGGGCAAGGCAGAAGGATCGCTTGAGCCCAGGCACTCAAGACCAGCCTGGGCAACAGAGTGAGACCCTGTCTCTGCAAAAAATTTAAAAATCAGCCAGGTGTGGTGACACATGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGTAGGAGGGTCCTTTGAGCCCAGGAGGTCAAGCTGTGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCTGTCTCAAAAACAAACTAAAAATGGTACATTGAGAGAAGTGGCACTTGCATCATTGTCAAAGGCCAGAAAAAGGTAGTGCTGAAATAAACCAGGCTCCTTTCAACAACCTGGCCACAGCTTATGGAG
GAGACAGCCCAATAAAATATATTCTGGCTGGGTGTGGAGGTTCACGCCTCTAATGGTAGCACTTTGGGAGGATGAGGCGAGAGGATTGCTTGAGGCCAGGAGTTTGAGACCAAACTGGGTAACATAGTAAAATGTCACCTCTGTAAAAAAAAAAAAATAGCCAGGCATAGTGGTGTACACCTCTAGTTCCAGCTACTCAGGAGGCTGAAGTGGGAAAGCAGCTTGAGCCTAGGAGTTGGAGGCTGTGTGAGCTATGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTATAAAAAAATATATATTCCAACTAATAAAAGCTAAGAATGTGACTGAAATTAATGCATTCTAGTTTAAAAAATAAAGAGATTTTAAAGACGGCATCTTAAAGTCAAGTAGTATTATGTCTACGTCCTATAGACCATTACTCTGTTGTAGCACAGAACAGACCAAATAGTATTCTATTCTTCAGAAGTTTGCACCTCTAGCTTTATAGCATAAACACAGAGTCAACACTGATAAATCCTGAAATACAACCTTGACCTACTAACCTGGCACCACTCCATTAGTGGCAATGGCACTCATGGAGATAGCAGTCAACATTGTCTGCAGAGAAAAGGAAAGGAGAGGATTGTTACTGTGTAAAGATGACATTTCTATACTACTTCTCCATTTGTGTTCCAAGAGCACTTGGCAAACATTTAACTCTACCTACTTTTATGGACAGTCATACCTAATGGTATGGAAATAAGATGATATGGTCCAATTCATTGCGCTAGTCATACCACTAATATCTGGAGGATTCTGTCAAAATGCTCCCACATCAGTAGGTCAGGTGCTATTAAGAACTGCTAATCTCACTCTGGATTTCCTAGTTACACAGGAAATAGAGCATAGTATACTCAAAAGGAAGAACTAGAGAAATAACTCAGAAAATAGGTTAGAACCTGACTAAAGACTAAATACAATATCAAGAACAATGTTCAGTAAGAAAGGGAATCACTGAAGGCTTCTGAGCACACAGGAACCGCATTTTAAAAATATTACCCGGTAGCACAGTATAGAATGCGCTGCAGATAGGAGTAGCTGGAGGCCGAGTGATTGGTTAGCAGGCTACCATAGTAGTTCAGTGAGAGGTAAAAACTATAGTGGTGGTAGTGTGAATAAAAAGGGCTGAGTGTAAAAGATTTCAGAGAATAGATTAGCGTTGGTAGCTGATTAGATGTGAAAAGCAATTAAGAAGCCAAACACAGCCTTGAGGTTTTAAGCCTGAGACTAAAAAAAGGTGGTACCATGAACATTTTAAGTTATTAAAAATATGAACTGTGCCTGCTTAACCTGTTTTGCTCATCAGCTGGGGATAATATACAGGTAGGGTATAAAGGTCATAGTGATAAAAAAGGACAGTAGAAAACTATAAAATTCATAGGTGTGTCTGGGATACATAATGAGAAGTTTAAATTAAAGGAAGATAAAAATGTTCTCAGTAGAGAGAAGACCTGGAAAGAACATCTAAATTTCTAAGGAAGGGATAAGGGAAGAAACTTCAAAACCAAATAAAAAAACCAAATACCCCTCACATCCGCAATAACCTGTCTTGTTTCTCAATATATACTGGAGTGATACATCACATTTTCTAACACATTTTCTGTCACAACTTTGGTGCTATCAAGCTCAAATAGTTTGGATTCTGAATTCTCTGAAGACAGGAACTTTATCTTCCATTTTCAGTTGAAGTCTTGCTTTGTAATTTCTAGTACATCATATAATAGATAGCAAGCAGTGACTAACAGGCACTGAATAACTGAAAATCCTTTAGATTTTAATATCAGAATAATTTCTTCTGTTGAGATCATGAGTCCTTCCCTAAGTATTCTTTGTTTTATTCCCAAAGAGGTCATGTGCATCTGCTCTTGAGAACTTGCAACGTTCAGGTGATCTCTAGGAGCCAGTGCAGTACTTACACAGCAGCAGCAGATAAGGACAATTGCAAAAGCCTGAAGAACTCCAGCTGTGCCCACCACCCATGTAAGGTGTAAAAAAAGGATCACTCCAAAAATATTTTGTAGACATGGGAGGTAGACACCCATGAAGGTACCCATTTGGGGGGTCTAGAAAGAAAGACATTGATAAAAAATCACACAGTTATCCTAAAGAGAGGTTTTTATTCTTTTATGTAATAACTTGCTCCCTAACTACCATATTAACCTCCAAGCAGAAATCATAAGTTTAATCAATACCTTCAAAAGGGCACATATAAAATCTCCATCTTTCAAGTGTTTATCACCATACTTTTATTATTCCTAAAGCTATATATTTTAACTTTACAAAGGTTCCTGCATGTGTTTATTATACATAGGCATTTGGCCACAAATAAACTTTTATGTGCACCCACAACAATTTAAAATTTTGTTTTTCAAAGCTGTTGGCTTTTTTCATTTAAAAACAATAAGGACTTGATGGAATTTCTTCAGAATTTGGCATAAATTCTTCACAGTAGTTAGTAAATAAATTAGATGGCAAAATGAAGATCTGAGGGCCGTTTTATCCCTTTTTGAAAGGGCTGAACAACCAGAATGGTAAACTGAATGTCTTATATTTTCATTTTGAGACAAACTGATGTTTGGTGTTTAAAAAACCCAACAACTTCACAACAGACAGATGGCATCAGCAGATGGGTATGGACACTCTTCTCTTGAAAAGCTATTCCCTCTCCCTGAATGCTCTTTTCCCACATAGCTCACTCCCTCCCATCAGCTAGATCTCTCCTCAAATATCACCTTGTCAGAAAGGCTTTCCCTGTCCAACCTATGTAAGTAGCAACGCCCTCCACTCTGGATCCCTTGCCAATTTCAGTCTCTCTACTCTGCTTAATTTTTTGCTCGGGAATTTATCAACACTTAATATGTTATATACTTTGGCAGTTAAAACAGCTTAAGGACTGTATCCCCACATCAGAATTTAGACTGCATCATATGTTTTCTTTGTGCTATGACGCTGGTGCCCAGAACAGTTCCAGGCACCTCTCAAGCATTTAATAAATAGCTGCTGAACACAGAATGGTGCCTTAGGTATTTCCTTCTTTCTTATATACAGGGCTCTTTCTATGTATTCCTTGTTATTCTGAGGCCTCACCTTGGTGGGCTTCTTTTTCCCTTCAGTGATGTTTTCTGCCTCTTCATGTTCCTTTGCTCCTTGAGTCAGATTAGTGTAATTGGCCATGCGGTTGAGGAGGGAAGACACCTTCGGTCTGGTGTCCATTTCTTCCTATAAAGCCAGTGACATGGAAGAAATGAGCTACAAAGAACACTGAACATAAGTATCAAAATAATCTTGCTACCAGAAAACTTCAAATTAAATGAAAAAATATTTCACAGGTAGGCCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGCTGGATCACCTGAGGCTGGGAGTTTGAGACCAGCCTGGCCAAGATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATAAGCTGGGTGTGGTGGCACGTGCCTGTAATCCCAGCTACACGGGAGGCTGAGGCGGGAGAATCAGCTTGAACCCAGGAGGCAGAAGTTGCAGTGAGCCGAGATCGCGCCACTGCGCTCCAGCCTGGGCAACAGAGGGAGACTCCATCTCAAAAAAAAAAAAAAAATTGGTACATTGAGTTGGGCATGGTGGCTCACACCTGCTAACCCAATGCTATGGGAGGGCAAGGCAGAAGGATCGCTTGAGCCCAGGCACTCAAGACCAGCCTGGGCAACAGAGTGAGACCCTGTCTCTGCAAAAAATTTAAAAATCAGCCAGGTGTGGTGACACATGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGTAGGAGGGTCCTTTGAGCCCAGGAGGTCAAGCTGTGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCTGTCTCAAAAACAAACTAAAAATGGTACATTGAGAGAAGTGGCACTTGCATCATTGTCAAAGGCCAGAAAAAGGTAGTGCTGAAATAAACCAGGCTCCTTTCAACAACCTGGCCACAGCTTATGGAG
Task1_train_20502
This variant lies on Chromosome 15 and affects the gene NOP10 (NOP10 ribonucleoprotein). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Dyskeratosis congenita, autosomal recessive 1
TAACTCTTTAAAATCCTTCAGATCCAATGTTAAGAACCCTGCAAGTAAGTGAACAGGCTAAGAAATAAAATTCCTTGACAGGAAACAAGTATCTCATTTCACCATTCCTATATGTTTCAGTAATGTATTTCAAAATCATCTGTCTTCTATTAATTATGACTCCAGTTGAGAGACTTTTTTTTTTCTTTTCAGCAACCCACAACTATCCTGAACTTTTCTGCTGGGATGGTCAAATAGCAAGATCCAAGAAAAGCAAAGTCTGGCCGGGCACTGTGGCTCACGCCCGTAATCCCAACACTTTGGGAGGCCAAGGCAGGAGGACAGCTTGAGCCCGGAGTGCAACACCAGCTTGGGCAACATAGTGAGACCTCGTTTCTATAAAAAATTTAAAAATGGGGTGGACCGCTTGAGACAGGGAGGTAGAGGCTGCAATGAGTTGTGATCACATCACTGCACTCCTGCCTGGACCACAGGAGTGAGACCTGACTCAAAAAAAAAAAAAAAGTATTTCCAGGGTATGTCTTCATAAATCACATCTGTGCTAATTTAAGTTATATCTGCTTCTGGAATCTAGAATTTTTATCATAGAAAATAAAGATTGCAGAATTAAAATACAGACTCCACAAAGCAATTTTAAAATCTGCAGCACTAGGCCGGCCAAGGTGGCTCATGCCCGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATTACTTGAGGTCAGGAGTTTGAGATCAGCCTGACCAACAAGGTGAAACCTTGTTTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGTGTGCGCCTGTAGTCCTAGCTACTCGGGAGGCTGAGGCAGGAGAATAGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATGGCGCCACTGCACTCCAGCCTGGGGTACAAGAGCAAAACTCCATCTCAAAAAAAAAGAAAGACCCAGGCCAGGTGTGGTGACTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACTTGAGGTGAGGAGTTTGAGACCAGCTTGGCCGACATGGCGAAACCCTGTCACTACTAAAAGAAATACAAAAATTAGCCAGGTGTGGTGGCGTGCACCTGTAATCCCAGTTACTTGGGAAGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGACGGAGGTTGTAGTCAGCCAAGGCTGCACCCCTGCACTCCAGCCTGGACAACAGATCTAGACTCTGTCTCAAAAGAAAAAAAAAGAAAGGCCCACCACTAAATCAATTTGAGTTCAAAGATAAGTTAATCAGGAGAAAAATCAGACTAAACAGGTTAAGTAACTTTCTCAAAGTTATACAAAAAGCAAATACTGGTCTTCTGACTTTCAATTCACTGACCTCTGTCTGTAATATGCCTATTACTTTTACAAGTACTCTTCCATTTTTAATCAAAATCTTATTTCAAGGGACAAGAAATTACGTTAAGTGACAACAGAGGTATTTTTCAGTGAATGCTGACAGCTGTGAAAGTCTTAATCTTTCTTCCCCAATACCCTCCTATCATGAACAGCACATGACCACTCTTGCAACAGCAGGACTGAAGTTTTTCTTCCAAGTGGTATTGTTGCAACTCTCTGGGGTACTCTCCTTTATCATCTCCCTCCCTTTAAAAAAATACTGCCAATCCTTTCCTCCAACAACTCACAAAATAAGAGTTTTTCAAATCATTTTATCTTTAATAATCTTGTAGTAATTTAAAATATGAGAAAAAAAAGTCAAATGTGTTCCCTTTATGGGTGATGCCACCATGATTGCCTCACACAAGCATAATCAATCGCCACGAGAGACTGGATGCCAAAGAGTATGGCTGGCAAAAAGGCATCAGGGCTCACAGTCCGAAGAGTTTGGTTACGGAGTCTCCGAGGGGTAACAGGTGGCAGAAAAGACATCAGTTTAAGGGACCCTCAGAGGACAGGGCGCGGTTGCTGGGTCATGAGCACCTTGAAGCGTTTCTTGATGGTGATTCGGTGTCGAGAGTATTTGTCATCTGGGGAGAACCGAGCAGGATGGGCTGAGCAGGTCTGTTGTCCCATCGGGTCAAATTTCTGCTCCAGGAACACAGAATGTATGTCAGTACAGGAGTGATGAAATGGGGTGGGGCCAGCGCGAAAAAGGGCAAACATGAAAATAGAAGATGCAATGGTCAACTCAAAAAGTTGTACAAATAAATAGAGAAATATAAAATTTAAAAAGGCCGAGCGCGGTGGCTCACGCCTGTAATCCTGGCACTTTGGGAGGTCGAGGCGGGAGGATGGTTTGAGACCAGCCTGGGCAATATGGCGAAACCTCGTCTCTACAACAAACAAACAAACAAAACCAACCAACCAAACAAAAAACCCCAAAACCAAAAATTAGCCGGGTATGGTGGCGCACGCCTGTAGTCCCAACTACTCGGGAGGCTGAGGCAGAAGGATTGTTTGAGCCCAGGAGGCGGAGGTTGCAGTGAGCCGAGACCGCACCACCGCACTACAGCCTAGGCAACAAAGCGAGTCCCTGTCTTTAAAAAAAAAAAAAAAAAAAAAAAGGAAAAGTGAGTGCAATGGCGCTATCCCGGCTCACTGCAACCTCTGCCTCCCGGGTTTAAGCGATTCTCCTGTCTCAGCCTCCCGAGTAGCTGGGATAACAGGCGCACACCGCCATGCCCGGCTAATTTTTTGTATTTTAGTAGAAACGGAGTTTCACAGTGTTGCCCAGAATGGTCGCGAACTCCTGAGCTAAGGCAATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGGGAGCCACTGCGCCCCGCCAGAATTTTTTCTTTTAATTAAAAAATGAGTCGCGCGGTCCCGGTTCTTCCCCACCTCGGTTCTGGACTTTCTGGTTCCCCGCACCCAGCTAGGTAACTCCACGTATGACCTCACCCACTCCTCCCATCTACATTTCTCGCCATGCCTATTTACACCCTGTTTTCTCTCCTCACCTTCAGCGTATAGACTCGATCTCCCTGCTCGTTGAGGTAATACTGGAGAAACATGATCGCTTATAAGCCAGCGGTCCCAATTCGGTCCACCGCTCAGTCTGCAGTGGTCCGCCCGACCGCGTCACGTGTTCGTCAATTTCCTTCCTGCATAACCGGAAGTCTCTCTCTCCTGGCACTCCGGAAAATGTAGTCAATTTTTGCCTTGTTTTCAGCTAGCCAGAAGGGGGCGCACGAGAGCAGGGCTTGGCTTGGGGCCCTACTTGCAACTTTGCAGGCTAAAACACGTGGAGTGTCCCTACTGTGTGCTAGGTACACGGCGTTAGAGGGGGGTAGGGATGGATGTGGATAGAATATTGACGTATAGAAGCCTGTCTTTGTCTCAAGATACACACCCATTTCAGGAGCAGTGAGTTTTCAATGCCTGAAGAAACAAGGGCTCCAGGATTCAGAGCCCCTTTACCCTAGGGAAGAAAGAAGAGGTTTTCTTCCCTCCCCTCTTTTACATCCAGTTCCCCTGCTCCATTTCAAAGCGTTGGCGGTAAAGAATGCATGTTGAGTATCAATATTCCGTAAAGCGAAAGAGCGTAAAGTTATTTTATGAAACTGGTGAAGCATGTTTCAGCGGTCGAACCAAGATTTAAAGTTAGGTCCCTACCGCAAATTCAGCGCTCTTTCTTATGGTGGTGAGTAGCTAATAATAACGTAATAAAGTGCACCTTCTAGGAGTTTTTACAATTTTTAAAAGAATATAGAAGTTCTCCTTATAAGACTCTCGTTTAAAGAAATGAAAATGAGAACCAAAATATCATTACAAAGATCATCGTTACGCCATTATTTACAATGACAAAAGCATTGGAATATATATTAACTGTGTAACCAGAAAAACCTGCACTTTTTTTTTTTTTTTTTTAAGAATATGGTTTGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAACACTGGGAGGCTGAGGCAGGCAGATCACAGGTCAAGGGTTCGAGACCAGCCTGGCCAATCTGGCGAAACCCCGTCTCTACTAAAAATACAGAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCT
TAACTCTTTAAAATCCTTCAGATCCAATGTTAAGAACCCTGCAAGTAAGTGAACAGGCTAAGAAATAAAATTCCTTGACAGGAAACAAGTATCTCATTTCACCATTCCTATATGTTTCAGTAATGTATTTCAAAATCATCTGTCTTCTATTAATTATGACTCCAGTTGAGAGACTTTTTTTTTTCTTTTCAGCAACCCACAACTATCCTGAACTTTTCTGCTGGGATGGTCAAATAGCAAGATCCAAGAAAAGCAAAGTCTGGCCGGGCACTGTGGCTCACGCCCGTAATCCCAACACTTTGGGAGGCCAAGGCAGGAGGACAGCTTGAGCCCGGAGTGCAACACCAGCTTGGGCAACATAGTGAGACCTCGTTTCTATAAAAAATTTAAAAATGGGGTGGACCGCTTGAGACAGGGAGGTAGAGGCTGCAATGAGTTGTGATCACATCACTGCACTCCTGCCTGGACCACAGGAGTGAGACCTGACTCAAAAAAAAAAAAAAAGTATTTCCAGGGTATGTCTTCATAAATCACATCTGTGCTAATTTAAGTTATATCTGCTTCTGGAATCTAGAATTTTTATCATAGAAAATAAAGATTGCAGAATTAAAATACAGACTCCACAAAGCAATTTTAAAATCTGCAGCACTAGGCCGGCCAAGGTGGCTCATGCCCGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATTACTTGAGGTCAGGAGTTTGAGATCAGCCTGACCAACAAGGTGAAACCTTGTTTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGTGTGCGCCTGTAGTCCTAGCTACTCGGGAGGCTGAGGCAGGAGAATAGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATGGCGCCACTGCACTCCAGCCTGGGGTACAAGAGCAAAACTCCATCTCAAAAAAAAAGAAAGACCCAGGCCAGGTGTGGTGACTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACTTGAGGTGAGGAGTTTGAGACCAGCTTGGCCGACATGGCGAAACCCTGTCACTACTAAAAGAAATACAAAAATTAGCCAGGTGTGGTGGCGTGCACCTGTAATCCCAGTTACTTGGGAAGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGACGGAGGTTGTAGTCAGCCAAGGCTGCACCCCTGCACTCCAGCCTGGACAACAGATCTAGACTCTGTCTCAAAAGAAAAAAAAAGAAAGGCCCACCACTAAATCAATTTGAGTTCAAAGATAAGTTAATCAGGAGAAAAATCAGACTAAACAGGTTAAGTAACTTTCTCAAAGTTATACAAAAAGCAAATACTGGTCTTCTGACTTTCAATTCACTGACCTCTGTCTGTAATATGCCTATTACTTTTACAAGTACTCTTCCATTTTTAATCAAAATCTTATTTCAAGGGACAAGAAATTACGTTAAGTGACAACAGAGGTATTTTTCAGTGAATGCTGACAGCTGTGAAAGTCTTAATCTTTCTTCCCCAATACCCTCCTATCATGAACAGCACATGACCACTCTTGCAACAGCAGGACTGAAGTTTTTCTTCCAAGTGGTATTGTTGCAACTCTCTGGGGTACTCTCCTTTATCATCTCCCTCCCTTTAAAAAAATACTGCCAATCCTTTCCTCCAACAACTCACAAAATAAGAGTTTTTCAAATCATTTTATCTTTAATAATCTTGTAGTAATTTAAAATATGAGAAAAAAAAGTCAAATGTGTTCCCTTTATGGGTGATGCCACCATGATTGCCTCACACAAGCATAATCAATCGCCACGAGAGACTGGATGCCAAAGAGTATGGCTGGCAAAAAGGCATCAGGGCTCACAGTCCGAAGAGTTTGGTTACGGAGTCTCCGAGGGGTAACAGGTGGCAGAAAAGACATCAGTTTAAGGGACCCTCAGAGGACAGGGCGCGGTTGCTGGGTCATGAGCACCTTGAAGCGTTTCTTGATGGTGATTCGGTGTCGAGAGTATTTGTCATCTGGGGAGAACCAAGCAGGATGGGCTGAGCAGGTCTGTTGTCCCATCGGGTCAAATTTCTGCTCCAGGAACACAGAATGTATGTCAGTACAGGAGTGATGAAATGGGGTGGGGCCAGCGCGAAAAAGGGCAAACATGAAAATAGAAGATGCAATGGTCAACTCAAAAAGTTGTACAAATAAATAGAGAAATATAAAATTTAAAAAGGCCGAGCGCGGTGGCTCACGCCTGTAATCCTGGCACTTTGGGAGGTCGAGGCGGGAGGATGGTTTGAGACCAGCCTGGGCAATATGGCGAAACCTCGTCTCTACAACAAACAAACAAACAAAACCAACCAACCAAACAAAAAACCCCAAAACCAAAAATTAGCCGGGTATGGTGGCGCACGCCTGTAGTCCCAACTACTCGGGAGGCTGAGGCAGAAGGATTGTTTGAGCCCAGGAGGCGGAGGTTGCAGTGAGCCGAGACCGCACCACCGCACTACAGCCTAGGCAACAAAGCGAGTCCCTGTCTTTAAAAAAAAAAAAAAAAAAAAAAAGGAAAAGTGAGTGCAATGGCGCTATCCCGGCTCACTGCAACCTCTGCCTCCCGGGTTTAAGCGATTCTCCTGTCTCAGCCTCCCGAGTAGCTGGGATAACAGGCGCACACCGCCATGCCCGGCTAATTTTTTGTATTTTAGTAGAAACGGAGTTTCACAGTGTTGCCCAGAATGGTCGCGAACTCCTGAGCTAAGGCAATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGGGAGCCACTGCGCCCCGCCAGAATTTTTTCTTTTAATTAAAAAATGAGTCGCGCGGTCCCGGTTCTTCCCCACCTCGGTTCTGGACTTTCTGGTTCCCCGCACCCAGCTAGGTAACTCCACGTATGACCTCACCCACTCCTCCCATCTACATTTCTCGCCATGCCTATTTACACCCTGTTTTCTCTCCTCACCTTCAGCGTATAGACTCGATCTCCCTGCTCGTTGAGGTAATACTGGAGAAACATGATCGCTTATAAGCCAGCGGTCCCAATTCGGTCCACCGCTCAGTCTGCAGTGGTCCGCCCGACCGCGTCACGTGTTCGTCAATTTCCTTCCTGCATAACCGGAAGTCTCTCTCTCCTGGCACTCCGGAAAATGTAGTCAATTTTTGCCTTGTTTTCAGCTAGCCAGAAGGGGGCGCACGAGAGCAGGGCTTGGCTTGGGGCCCTACTTGCAACTTTGCAGGCTAAAACACGTGGAGTGTCCCTACTGTGTGCTAGGTACACGGCGTTAGAGGGGGGTAGGGATGGATGTGGATAGAATATTGACGTATAGAAGCCTGTCTTTGTCTCAAGATACACACCCATTTCAGGAGCAGTGAGTTTTCAATGCCTGAAGAAACAAGGGCTCCAGGATTCAGAGCCCCTTTACCCTAGGGAAGAAAGAAGAGGTTTTCTTCCCTCCCCTCTTTTACATCCAGTTCCCCTGCTCCATTTCAAAGCGTTGGCGGTAAAGAATGCATGTTGAGTATCAATATTCCGTAAAGCGAAAGAGCGTAAAGTTATTTTATGAAACTGGTGAAGCATGTTTCAGCGGTCGAACCAAGATTTAAAGTTAGGTCCCTACCGCAAATTCAGCGCTCTTTCTTATGGTGGTGAGTAGCTAATAATAACGTAATAAAGTGCACCTTCTAGGAGTTTTTACAATTTTTAAAAGAATATAGAAGTTCTCCTTATAAGACTCTCGTTTAAAGAAATGAAAATGAGAACCAAAATATCATTACAAAGATCATCGTTACGCCATTATTTACAATGACAAAAGCATTGGAATATATATTAACTGTGTAACCAGAAAAACCTGCACTTTTTTTTTTTTTTTTTTAAGAATATGGTTTGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAACACTGGGAGGCTGAGGCAGGCAGATCACAGGTCAAGGGTTCGAGACCAGCCTGGCCAATCTGGCGAAACCCCGTCTCTACTAAAAATACAGAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCT
Task1_train_20503
A mutation found in NOP10 (NOP10 ribonucleoprotein) on Chromosome 15 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 2
GTGACTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACTTGAGGTGAGGAGTTTGAGACCAGCTTGGCCGACATGGCGAAACCCTGTCACTACTAAAAGAAATACAAAAATTAGCCAGGTGTGGTGGCGTGCACCTGTAATCCCAGTTACTTGGGAAGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGACGGAGGTTGTAGTCAGCCAAGGCTGCACCCCTGCACTCCAGCCTGGACAACAGATCTAGACTCTGTCTCAAAAGAAAAAAAAAGAAAGGCCCACCACTAAATCAATTTGAGTTCAAAGATAAGTTAATCAGGAGAAAAATCAGACTAAACAGGTTAAGTAACTTTCTCAAAGTTATACAAAAAGCAAATACTGGTCTTCTGACTTTCAATTCACTGACCTCTGTCTGTAATATGCCTATTACTTTTACAAGTACTCTTCCATTTTTAATCAAAATCTTATTTCAAGGGACAAGAAATTACGTTAAGTGACAACAGAGGTATTTTTCAGTGAATGCTGACAGCTGTGAAAGTCTTAATCTTTCTTCCCCAATACCCTCCTATCATGAACAGCACATGACCACTCTTGCAACAGCAGGACTGAAGTTTTTCTTCCAAGTGGTATTGTTGCAACTCTCTGGGGTACTCTCCTTTATCATCTCCCTCCCTTTAAAAAAATACTGCCAATCCTTTCCTCCAACAACTCACAAAATAAGAGTTTTTCAAATCATTTTATCTTTAATAATCTTGTAGTAATTTAAAATATGAGAAAAAAAAGTCAAATGTGTTCCCTTTATGGGTGATGCCACCATGATTGCCTCACACAAGCATAATCAATCGCCACGAGAGACTGGATGCCAAAGAGTATGGCTGGCAAAAAGGCATCAGGGCTCACAGTCCGAAGAGTTTGGTTACGGAGTCTCCGAGGGGTAACAGGTGGCAGAAAAGACATCAGTTTAAGGGACCCTCAGAGGACAGGGCGCGGTTGCTGGGTCATGAGCACCTTGAAGCGTTTCTTGATGGTGATTCGGTGTCGAGAGTATTTGTCATCTGGGGAGAACCGAGCAGGATGGGCTGAGCAGGTCTGTTGTCCCATCGGGTCAAATTTCTGCTCCAGGAACACAGAATGTATGTCAGTACAGGAGTGATGAAATGGGGTGGGGCCAGCGCGAAAAAGGGCAAACATGAAAATAGAAGATGCAATGGTCAACTCAAAAAGTTGTACAAATAAATAGAGAAATATAAAATTTAAAAAGGCCGAGCGCGGTGGCTCACGCCTGTAATCCTGGCACTTTGGGAGGTCGAGGCGGGAGGATGGTTTGAGACCAGCCTGGGCAATATGGCGAAACCTCGTCTCTACAACAAACAAACAAACAAAACCAACCAACCAAACAAAAAACCCCAAAACCAAAAATTAGCCGGGTATGGTGGCGCACGCCTGTAGTCCCAACTACTCGGGAGGCTGAGGCAGAAGGATTGTTTGAGCCCAGGAGGCGGAGGTTGCAGTGAGCCGAGACCGCACCACCGCACTACAGCCTAGGCAACAAAGCGAGTCCCTGTCTTTAAAAAAAAAAAAAAAAAAAAAAAGGAAAAGTGAGTGCAATGGCGCTATCCCGGCTCACTGCAACCTCTGCCTCCCGGGTTTAAGCGATTCTCCTGTCTCAGCCTCCCGAGTAGCTGGGATAACAGGCGCACACCGCCATGCCCGGCTAATTTTTTGTATTTTAGTAGAAACGGAGTTTCACAGTGTTGCCCAGAATGGTCGCGAACTCCTGAGCTAAGGCAATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGGGAGCCACTGCGCCCCGCCAGAATTTTTTCTTTTAATTAAAAAATGAGTCGCGCGGTCCCGGTTCTTCCCCACCTCGGTTCTGGACTTTCTGGTTCCCCGCACCCAGCTAGGTAACTCCACGTATGACCTCACCCACTCCTCCCATCTACATTTCTCGCCATGCCTATTTACACCCTGTTTTCTCTCCTCACCTTCAGCGTATAGACTCGATCTCCCTGCTCGTTGAGGTAATACTGGAGAAACATGATCGCTTATAAGCCAGCGGTCCCAATTCGGTCCACCGCTCAGTCTGCAGTGGTCCGCCCGACCGCGTCACGTGTTCGTCAATTTCCTTCCTGCATAACCGGAAGTCTCTCTCTCCTGGCACTCCGGAAAATGTAGTCAATTTTTGCCTTGTTTTCAGCTAGCCAGAAGGGGGCGCACGAGAGCAGGGCTTGGCTTGGGGCCCTACTTGCAACTTTGCAGGCTAAAACACGTGGAGTGTCCCTACTGTGTGCTAGGTACACGGCGTTAGAGGGGGGTAGGGATGGATGTGGATAGAATATTGACGTATAGAAGCCTGTCTTTGTCTCAAGATACACACCCATTTCAGGAGCAGTGAGTTTTCAATGCCTGAAGAAACAAGGGCTCCAGGATTCAGAGCCCCTTTACCCTAGGGAAGAAAGAAGAGGTTTTCTTCCCTCCCCTCTTTTACATCCAGTTCCCCTGCTCCATTTCAAAGCGTTGGCGGTAAAGAATGCATGTTGAGTATCAATATTCCGTAAAGCGAAAGAGCGTAAAGTTATTTTATGAAACTGGTGAAGCATGTTTCAGCGGTCGAACCAAGATTTAAAGTTAGGTCCCTACCGCAAATTCAGCGCTCTTTCTTATGGTGGTGAGTAGCTAATAATAACGTAATAAAGTGCACCTTCTAGGAGTTTTTACAATTTTTAAAAGAATATAGAAGTTCTCCTTATAAGACTCTCGTTTAAAGAAATGAAAATGAGAACCAAAATATCATTACAAAGATCATCGTTACGCCATTATTTACAATGACAAAAGCATTGGAATATATATTAACTGTGTAACCAGAAAAACCTGCACTTTTTTTTTTTTTTTTTTAAGAATATGGTTTGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAACACTGGGAGGCTGAGGCAGGCAGATCACAGGTCAAGGGTTCGAGACCAGCCTGGCCAATCTGGCGAAACCCCGTCTCTACTAAAAATACAGAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTTCAGAGGCTGAGGCAGGAGAATCATTTGAGCCGGGGAGGCAGAGGTTGCAGCGAGCTGAGATAGCACCACTGCACTCCAGCCTGGGTCCGTCTTAAAGAAAAAAAAATATGGTTTGTGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACGGGTGGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCAATATGGTGAAACCCCCAAAAATACAAAAATTAGCGGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGATCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGAATATGGTTTGTATTTACTTGTAGTTGCATAAAAAATCTCTGCAAGTATTCACAAGAAACAGATGATACTGGTTTCCTCTGGGATAGAGAACTTAGTTGCAGGAGAAAGGGGTAAGGGTTGGGAGGCAGACTTATTGCTATGTATTTTATTACGCAGTTTGATTTTTGAACCTTGCTAATGTATTTATTACCTGTTAAAAATTTTTTAAAGGCCGGGCACGGTGGCTCACGCCTAGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCATGAGGTCAGGAGATCGAGACTATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCATGGTGGTGGGTGCCTGTAGTCCCAGCTACTCAGGAGGGTGAGGCAGGACAATGGCGTGAACCCGGAAGGCGGAGCTTGCAGTGAGCAGAGATCACGCCACTGCACTACAGCCTGGGTGACAGAGCGAGACTCTGTTTAAAAAAAAAAATTTAAATCTAAGTAGTTAATTTTGTTAGAAAGGAAAATGATGATTTT
GTGACTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACTTGAGGTGAGGAGTTTGAGACCAGCTTGGCCGACATGGCGAAACCCTGTCACTACTAAAAGAAATACAAAAATTAGCCAGGTGTGGTGGCGTGCACCTGTAATCCCAGTTACTTGGGAAGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGACGGAGGTTGTAGTCAGCCAAGGCTGCACCCCTGCACTCCAGCCTGGACAACAGATCTAGACTCTGTCTCAAAAGAAAAAAAAAGAAAGGCCCACCACTAAATCAATTTGAGTTCAAAGATAAGTTAATCAGGAGAAAAATCAGACTAAACAGGTTAAGTAACTTTCTCAAAGTTATACAAAAAGCAAATACTGGTCTTCTGACTTTCAATTCACTGACCTCTGTCTGTAATATGCCTATTACTTTTACAAGTACTCTTCCATTTTTAATCAAAATCTTATTTCAAGGGACAAGAAATTACGTTAAGTGACAACAGAGGTATTTTTCAGTGAATGCTGACAGCTGTGAAAGTCTTAATCTTTCTTCCCCAATACCCTCCTATCATGAACAGCACATGACCACTCTTGCAACAGCAGGACTGAAGTTTTTCTTCCAAGTGGTATTGTTGCAACTCTCTGGGGTACTCTCCTTTATCATCTCCCTCCCTTTAAAAAAATACTGCCAATCCTTTCCTCCAACAACTCACAAAATAAGAGTTTTTCAAATCATTTTATCTTTAATAATCTTGTAGTAATTTAAAATATGAGAAAAAAAAGTCAAATGTGTTCCCTTTATGGGTGATGCCACCATGATTGCCTCACACAAGCATAATCAATCGCCACGAGAGACTGGATGCCAAAGAGTATGGCTGGCAAAAAGGCATCAGGGCTCACAGTCCGAAGAGTTTGGTTACGGAGTCTCCGAGGGGTAACAGGTGGCAGAAAAGACATCAGTTTAAGGGACCCTCAGAGGACAGGGCGCGGTTGCTGGGTCATGAGCACCTTGAAGCGTTTCTTGATGGTGATTCGGTGTCGAGAGTATTTGTCATCTGGGGAGAACCGAGCAGGATGGGCTGAGCAGGTCTGTTGTCCCATCGGGTCAAATTTCTGCTCCAGGAACACAGAATGTATGTCAGTACAGGAGTGATGAAATGGGGTGGGGCCAGCGCGAAAAAGGGCAAACATGAAAATAGAAGATGCAATGGTCAACTCAAAAAGTTGTACAAATAAATAGAGAAATATAAAATTTAAAAAGGCCGAGCGCGGTGGCTCACGCCTGTAATCCTGGCACTTTGGGAGGTCGAGGCGGGAGGATGGTTTGAGACCAGCCTGGGCAATATGGCGAAACCTCGTCTCTACAACAAACAAACAAACAAAACCAACCAACCAAACAAAAAACCCCAAAACCAAAAATTAGCCGGGTATGGTGGCGCACGCCTGTAGTCCCAACTACTCGGGAGGCTGAGGCAGAAGGATTGTTTGAGCCCAGGAGGCGGAGGTTGCAGTGAGCCGAGACCGCACCACCGCACTACAGCCTAGGCAACAAAGCGAGTCCCTGTCTTTAAAAAAAAAAAAAAAAAAAAAAAGGAAAAGTGAGTGCAATGGCGCTATCCCGGCTCACTGCAACCTCTGCCTCCCGGGTTTAAGCGATTCTCCTGTCTCAGCCTCCCGAGTAGCTGGGATAACAGGCGCACACCGCCATGCCCGGCTAATTTTTTGTATTTTAGTAGAAACGGAGTTTCACAGTGTTGCCCAGAATGGTCGCGAACTCCTGAGCTAAGGCAATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGGGAGCCACTGCGCCCCGCCAGAATTTTTTCTTTTAATTAAAAAATGAGTCGCGCGGTCCCGGTTCTTCCCCACCTCGGTTCTGGACTTTCTGGTTCCCCGCACCCAGCTAGGTAACTCCACGTATGACCTCACCCACTCCTCCCATCTACATTTCTCGCCATGCCTATTTACACCCTGTTTTCTCTCCTCACCTTCAGCATATAGACTCGATCTCCCTGCTCGTTGAGGTAATACTGGAGAAACATGATCGCTTATAAGCCAGCGGTCCCAATTCGGTCCACCGCTCAGTCTGCAGTGGTCCGCCCGACCGCGTCACGTGTTCGTCAATTTCCTTCCTGCATAACCGGAAGTCTCTCTCTCCTGGCACTCCGGAAAATGTAGTCAATTTTTGCCTTGTTTTCAGCTAGCCAGAAGGGGGCGCACGAGAGCAGGGCTTGGCTTGGGGCCCTACTTGCAACTTTGCAGGCTAAAACACGTGGAGTGTCCCTACTGTGTGCTAGGTACACGGCGTTAGAGGGGGGTAGGGATGGATGTGGATAGAATATTGACGTATAGAAGCCTGTCTTTGTCTCAAGATACACACCCATTTCAGGAGCAGTGAGTTTTCAATGCCTGAAGAAACAAGGGCTCCAGGATTCAGAGCCCCTTTACCCTAGGGAAGAAAGAAGAGGTTTTCTTCCCTCCCCTCTTTTACATCCAGTTCCCCTGCTCCATTTCAAAGCGTTGGCGGTAAAGAATGCATGTTGAGTATCAATATTCCGTAAAGCGAAAGAGCGTAAAGTTATTTTATGAAACTGGTGAAGCATGTTTCAGCGGTCGAACCAAGATTTAAAGTTAGGTCCCTACCGCAAATTCAGCGCTCTTTCTTATGGTGGTGAGTAGCTAATAATAACGTAATAAAGTGCACCTTCTAGGAGTTTTTACAATTTTTAAAAGAATATAGAAGTTCTCCTTATAAGACTCTCGTTTAAAGAAATGAAAATGAGAACCAAAATATCATTACAAAGATCATCGTTACGCCATTATTTACAATGACAAAAGCATTGGAATATATATTAACTGTGTAACCAGAAAAACCTGCACTTTTTTTTTTTTTTTTTTAAGAATATGGTTTGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAACACTGGGAGGCTGAGGCAGGCAGATCACAGGTCAAGGGTTCGAGACCAGCCTGGCCAATCTGGCGAAACCCCGTCTCTACTAAAAATACAGAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTTCAGAGGCTGAGGCAGGAGAATCATTTGAGCCGGGGAGGCAGAGGTTGCAGCGAGCTGAGATAGCACCACTGCACTCCAGCCTGGGTCCGTCTTAAAGAAAAAAAAATATGGTTTGTGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACGGGTGGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCAATATGGTGAAACCCCCAAAAATACAAAAATTAGCGGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGATCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGAATATGGTTTGTATTTACTTGTAGTTGCATAAAAAATCTCTGCAAGTATTCACAAGAAACAGATGATACTGGTTTCCTCTGGGATAGAGAACTTAGTTGCAGGAGAAAGGGGTAAGGGTTGGGAGGCAGACTTATTGCTATGTATTTTATTACGCAGTTTGATTTTTGAACCTTGCTAATGTATTTATTACCTGTTAAAAATTTTTTAAAGGCCGGGCACGGTGGCTCACGCCTAGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCATGAGGTCAGGAGATCGAGACTATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCATGGTGGTGGGTGCCTGTAGTCCCAGCTACTCAGGAGGGTGAGGCAGGACAATGGCGTGAACCCGGAAGGCGGAGCTTGCAGTGAGCAGAGATCACGCCACTGCACTACAGCCTGGGTGACAGAGCGAGACTCTGTTTAAAAAAAAAAATTTAAATCTAAGTAGTTAATTTTGTTAGAAAGGAAAATGATGATTTT
Task1_train_20504
Gene NOP10 (NOP10 ribonucleoprotein), found on Chromosome 15, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9
GGAGGCTGAGGTGGGTGGATCACTTGAGGTGAGGAGTTTGAGACCAGCTTGGCCGACATGGCGAAACCCTGTCACTACTAAAAGAAATACAAAAATTAGCCAGGTGTGGTGGCGTGCACCTGTAATCCCAGTTACTTGGGAAGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGACGGAGGTTGTAGTCAGCCAAGGCTGCACCCCTGCACTCCAGCCTGGACAACAGATCTAGACTCTGTCTCAAAAGAAAAAAAAAGAAAGGCCCACCACTAAATCAATTTGAGTTCAAAGATAAGTTAATCAGGAGAAAAATCAGACTAAACAGGTTAAGTAACTTTCTCAAAGTTATACAAAAAGCAAATACTGGTCTTCTGACTTTCAATTCACTGACCTCTGTCTGTAATATGCCTATTACTTTTACAAGTACTCTTCCATTTTTAATCAAAATCTTATTTCAAGGGACAAGAAATTACGTTAAGTGACAACAGAGGTATTTTTCAGTGAATGCTGACAGCTGTGAAAGTCTTAATCTTTCTTCCCCAATACCCTCCTATCATGAACAGCACATGACCACTCTTGCAACAGCAGGACTGAAGTTTTTCTTCCAAGTGGTATTGTTGCAACTCTCTGGGGTACTCTCCTTTATCATCTCCCTCCCTTTAAAAAAATACTGCCAATCCTTTCCTCCAACAACTCACAAAATAAGAGTTTTTCAAATCATTTTATCTTTAATAATCTTGTAGTAATTTAAAATATGAGAAAAAAAAGTCAAATGTGTTCCCTTTATGGGTGATGCCACCATGATTGCCTCACACAAGCATAATCAATCGCCACGAGAGACTGGATGCCAAAGAGTATGGCTGGCAAAAAGGCATCAGGGCTCACAGTCCGAAGAGTTTGGTTACGGAGTCTCCGAGGGGTAACAGGTGGCAGAAAAGACATCAGTTTAAGGGACCCTCAGAGGACAGGGCGCGGTTGCTGGGTCATGAGCACCTTGAAGCGTTTCTTGATGGTGATTCGGTGTCGAGAGTATTTGTCATCTGGGGAGAACCGAGCAGGATGGGCTGAGCAGGTCTGTTGTCCCATCGGGTCAAATTTCTGCTCCAGGAACACAGAATGTATGTCAGTACAGGAGTGATGAAATGGGGTGGGGCCAGCGCGAAAAAGGGCAAACATGAAAATAGAAGATGCAATGGTCAACTCAAAAAGTTGTACAAATAAATAGAGAAATATAAAATTTAAAAAGGCCGAGCGCGGTGGCTCACGCCTGTAATCCTGGCACTTTGGGAGGTCGAGGCGGGAGGATGGTTTGAGACCAGCCTGGGCAATATGGCGAAACCTCGTCTCTACAACAAACAAACAAACAAAACCAACCAACCAAACAAAAAACCCCAAAACCAAAAATTAGCCGGGTATGGTGGCGCACGCCTGTAGTCCCAACTACTCGGGAGGCTGAGGCAGAAGGATTGTTTGAGCCCAGGAGGCGGAGGTTGCAGTGAGCCGAGACCGCACCACCGCACTACAGCCTAGGCAACAAAGCGAGTCCCTGTCTTTAAAAAAAAAAAAAAAAAAAAAAAGGAAAAGTGAGTGCAATGGCGCTATCCCGGCTCACTGCAACCTCTGCCTCCCGGGTTTAAGCGATTCTCCTGTCTCAGCCTCCCGAGTAGCTGGGATAACAGGCGCACACCGCCATGCCCGGCTAATTTTTTGTATTTTAGTAGAAACGGAGTTTCACAGTGTTGCCCAGAATGGTCGCGAACTCCTGAGCTAAGGCAATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGGGAGCCACTGCGCCCCGCCAGAATTTTTTCTTTTAATTAAAAAATGAGTCGCGCGGTCCCGGTTCTTCCCCACCTCGGTTCTGGACTTTCTGGTTCCCCGCACCCAGCTAGGTAACTCCACGTATGACCTCACCCACTCCTCCCATCTACATTTCTCGCCATGCCTATTTACACCCTGTTTTCTCTCCTCACCTTCAGCGTATAGACTCGATCTCCCTGCTCGTTGAGGTAATACTGGAGAAACATGATCGCTTATAAGCCAGCGGTCCCAATTCGGTCCACCGCTCAGTCTGCAGTGGTCCGCCCGACCGCGTCACGTGTTCGTCAATTTCCTTCCTGCATAACCGGAAGTCTCTCTCTCCTGGCACTCCGGAAAATGTAGTCAATTTTTGCCTTGTTTTCAGCTAGCCAGAAGGGGGCGCACGAGAGCAGGGCTTGGCTTGGGGCCCTACTTGCAACTTTGCAGGCTAAAACACGTGGAGTGTCCCTACTGTGTGCTAGGTACACGGCGTTAGAGGGGGGTAGGGATGGATGTGGATAGAATATTGACGTATAGAAGCCTGTCTTTGTCTCAAGATACACACCCATTTCAGGAGCAGTGAGTTTTCAATGCCTGAAGAAACAAGGGCTCCAGGATTCAGAGCCCCTTTACCCTAGGGAAGAAAGAAGAGGTTTTCTTCCCTCCCCTCTTTTACATCCAGTTCCCCTGCTCCATTTCAAAGCGTTGGCGGTAAAGAATGCATGTTGAGTATCAATATTCCGTAAAGCGAAAGAGCGTAAAGTTATTTTATGAAACTGGTGAAGCATGTTTCAGCGGTCGAACCAAGATTTAAAGTTAGGTCCCTACCGCAAATTCAGCGCTCTTTCTTATGGTGGTGAGTAGCTAATAATAACGTAATAAAGTGCACCTTCTAGGAGTTTTTACAATTTTTAAAAGAATATAGAAGTTCTCCTTATAAGACTCTCGTTTAAAGAAATGAAAATGAGAACCAAAATATCATTACAAAGATCATCGTTACGCCATTATTTACAATGACAAAAGCATTGGAATATATATTAACTGTGTAACCAGAAAAACCTGCACTTTTTTTTTTTTTTTTTTAAGAATATGGTTTGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAACACTGGGAGGCTGAGGCAGGCAGATCACAGGTCAAGGGTTCGAGACCAGCCTGGCCAATCTGGCGAAACCCCGTCTCTACTAAAAATACAGAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTTCAGAGGCTGAGGCAGGAGAATCATTTGAGCCGGGGAGGCAGAGGTTGCAGCGAGCTGAGATAGCACCACTGCACTCCAGCCTGGGTCCGTCTTAAAGAAAAAAAAATATGGTTTGTGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACGGGTGGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCAATATGGTGAAACCCCCAAAAATACAAAAATTAGCGGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGATCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGAATATGGTTTGTATTTACTTGTAGTTGCATAAAAAATCTCTGCAAGTATTCACAAGAAACAGATGATACTGGTTTCCTCTGGGATAGAGAACTTAGTTGCAGGAGAAAGGGGTAAGGGTTGGGAGGCAGACTTATTGCTATGTATTTTATTACGCAGTTTGATTTTTGAACCTTGCTAATGTATTTATTACCTGTTAAAAATTTTTTAAAGGCCGGGCACGGTGGCTCACGCCTAGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCATGAGGTCAGGAGATCGAGACTATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCATGGTGGTGGGTGCCTGTAGTCCCAGCTACTCAGGAGGGTGAGGCAGGACAATGGCGTGAACCCGGAAGGCGGAGCTTGCAGTGAGCAGAGATCACGCCACTGCACTACAGCCTGGGTGACAGAGCGAGACTCTGTTTAAAAAAAAAAATTTAAATCTAAGTAGTTAATTTTGTTAGAAAGGAAAATGATGATTTTAGCCTTCAGGTCTTTAGAAAAGAGAAAAGA
GGAGGCTGAGGTGGGTGGATCACTTGAGGTGAGGAGTTTGAGACCAGCTTGGCCGACATGGCGAAACCCTGTCACTACTAAAAGAAATACAAAAATTAGCCAGGTGTGGTGGCGTGCACCTGTAATCCCAGTTACTTGGGAAGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGACGGAGGTTGTAGTCAGCCAAGGCTGCACCCCTGCACTCCAGCCTGGACAACAGATCTAGACTCTGTCTCAAAAGAAAAAAAAAGAAAGGCCCACCACTAAATCAATTTGAGTTCAAAGATAAGTTAATCAGGAGAAAAATCAGACTAAACAGGTTAAGTAACTTTCTCAAAGTTATACAAAAAGCAAATACTGGTCTTCTGACTTTCAATTCACTGACCTCTGTCTGTAATATGCCTATTACTTTTACAAGTACTCTTCCATTTTTAATCAAAATCTTATTTCAAGGGACAAGAAATTACGTTAAGTGACAACAGAGGTATTTTTCAGTGAATGCTGACAGCTGTGAAAGTCTTAATCTTTCTTCCCCAATACCCTCCTATCATGAACAGCACATGACCACTCTTGCAACAGCAGGACTGAAGTTTTTCTTCCAAGTGGTATTGTTGCAACTCTCTGGGGTACTCTCCTTTATCATCTCCCTCCCTTTAAAAAAATACTGCCAATCCTTTCCTCCAACAACTCACAAAATAAGAGTTTTTCAAATCATTTTATCTTTAATAATCTTGTAGTAATTTAAAATATGAGAAAAAAAAGTCAAATGTGTTCCCTTTATGGGTGATGCCACCATGATTGCCTCACACAAGCATAATCAATCGCCACGAGAGACTGGATGCCAAAGAGTATGGCTGGCAAAAAGGCATCAGGGCTCACAGTCCGAAGAGTTTGGTTACGGAGTCTCCGAGGGGTAACAGGTGGCAGAAAAGACATCAGTTTAAGGGACCCTCAGAGGACAGGGCGCGGTTGCTGGGTCATGAGCACCTTGAAGCGTTTCTTGATGGTGATTCGGTGTCGAGAGTATTTGTCATCTGGGGAGAACCGAGCAGGATGGGCTGAGCAGGTCTGTTGTCCCATCGGGTCAAATTTCTGCTCCAGGAACACAGAATGTATGTCAGTACAGGAGTGATGAAATGGGGTGGGGCCAGCGCGAAAAAGGGCAAACATGAAAATAGAAGATGCAATGGTCAACTCAAAAAGTTGTACAAATAAATAGAGAAATATAAAATTTAAAAAGGCCGAGCGCGGTGGCTCACGCCTGTAATCCTGGCACTTTGGGAGGTCGAGGCGGGAGGATGGTTTGAGACCAGCCTGGGCAATATGGCGAAACCTCGTCTCTACAACAAACAAACAAACAAAACCAACCAACCAAACAAAAAACCCCAAAACCAAAAATTAGCCGGGTATGGTGGCGCACGCCTGTAGTCCCAACTACTCGGGAGGCTGAGGCAGAAGGATTGTTTGAGCCCAGGAGGCGGAGGTTGCAGTGAGCCGAGACCGCACCACCGCACTACAGCCTAGGCAACAAAGCGAGTCCCTGTCTTTAAAAAAAAAAAAAAAAAAAAAAAGGAAAAGTGAGTGCAATGGCGCTATCCCGGCTCACTGCAACCTCTGCCTCCCGGGTTTAAGCGATTCTCCTGTCTCAGCCTCCCGAGTAGCTGGGATAACAGGCGCACACCGCCATGCCCGGCTAATTTTTTGTATTTTAGTAGAAACGGAGTTTCACAGTGTTGCCCAGAATGGTCGCGAACTCCTGAGCTAAGGCAATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGGGAGCCACTGCGCCCCGCCAGAATTTTTTCTTTTAATTAAAAAATGAGTCGCGCGGTCCCGGTTCTTCCCCACCTCGGTTCTGGACTTTCTGGTTCCCCGCACCCAGCTAGGTAACTCCACGTATGACCTCACCCACTCCTCCCATCTACATTTCTCGCCATGCCTATTTACACCCTGTTTTCTCTCCTCACCTTCAGCGTATAGACTCGATCTCCCTGCTCGTTGAGGCAATACTGGAGAAACATGATCGCTTATAAGCCAGCGGTCCCAATTCGGTCCACCGCTCAGTCTGCAGTGGTCCGCCCGACCGCGTCACGTGTTCGTCAATTTCCTTCCTGCATAACCGGAAGTCTCTCTCTCCTGGCACTCCGGAAAATGTAGTCAATTTTTGCCTTGTTTTCAGCTAGCCAGAAGGGGGCGCACGAGAGCAGGGCTTGGCTTGGGGCCCTACTTGCAACTTTGCAGGCTAAAACACGTGGAGTGTCCCTACTGTGTGCTAGGTACACGGCGTTAGAGGGGGGTAGGGATGGATGTGGATAGAATATTGACGTATAGAAGCCTGTCTTTGTCTCAAGATACACACCCATTTCAGGAGCAGTGAGTTTTCAATGCCTGAAGAAACAAGGGCTCCAGGATTCAGAGCCCCTTTACCCTAGGGAAGAAAGAAGAGGTTTTCTTCCCTCCCCTCTTTTACATCCAGTTCCCCTGCTCCATTTCAAAGCGTTGGCGGTAAAGAATGCATGTTGAGTATCAATATTCCGTAAAGCGAAAGAGCGTAAAGTTATTTTATGAAACTGGTGAAGCATGTTTCAGCGGTCGAACCAAGATTTAAAGTTAGGTCCCTACCGCAAATTCAGCGCTCTTTCTTATGGTGGTGAGTAGCTAATAATAACGTAATAAAGTGCACCTTCTAGGAGTTTTTACAATTTTTAAAAGAATATAGAAGTTCTCCTTATAAGACTCTCGTTTAAAGAAATGAAAATGAGAACCAAAATATCATTACAAAGATCATCGTTACGCCATTATTTACAATGACAAAAGCATTGGAATATATATTAACTGTGTAACCAGAAAAACCTGCACTTTTTTTTTTTTTTTTTTAAGAATATGGTTTGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAACACTGGGAGGCTGAGGCAGGCAGATCACAGGTCAAGGGTTCGAGACCAGCCTGGCCAATCTGGCGAAACCCCGTCTCTACTAAAAATACAGAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTTCAGAGGCTGAGGCAGGAGAATCATTTGAGCCGGGGAGGCAGAGGTTGCAGCGAGCTGAGATAGCACCACTGCACTCCAGCCTGGGTCCGTCTTAAAGAAAAAAAAATATGGTTTGTGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACGGGTGGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCAATATGGTGAAACCCCCAAAAATACAAAAATTAGCGGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGATCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGAATATGGTTTGTATTTACTTGTAGTTGCATAAAAAATCTCTGCAAGTATTCACAAGAAACAGATGATACTGGTTTCCTCTGGGATAGAGAACTTAGTTGCAGGAGAAAGGGGTAAGGGTTGGGAGGCAGACTTATTGCTATGTATTTTATTACGCAGTTTGATTTTTGAACCTTGCTAATGTATTTATTACCTGTTAAAAATTTTTTAAAGGCCGGGCACGGTGGCTCACGCCTAGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCATGAGGTCAGGAGATCGAGACTATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCATGGTGGTGGGTGCCTGTAGTCCCAGCTACTCAGGAGGGTGAGGCAGGACAATGGCGTGAACCCGGAAGGCGGAGCTTGCAGTGAGCAGAGATCACGCCACTGCACTACAGCCTGGGTGACAGAGCGAGACTCTGTTTAAAAAAAAAAATTTAAATCTAAGTAGTTAATTTTGTTAGAAAGGAAAATGATGATTTTAGCCTTCAGGTCTTTAGAAAAGAGAAAAGA
Task1_train_20505
Consider this mutation in ACTC1, GJD2-DT (actin alpha cardiac muscle 1| GJD2 divergent transcript) on Chromosome 15. Is this a benign change or a disease-causing variant?
Pathogenic; Atrial septal defect 5
TGTACAGAGGAAAAGAAAGAGACACAAAAACTAGTGAAATCATACCTCCCCATGCATGGCTTTTAAACCAGTTCAACTGTGCTATAGGATACAATGGGGTGGTGGGGGCGGGGGGCATATGTACAATAATGTTTGCACCTTATCTAAATAAAATGCCACCAAGTTGATGTATTATTTAGCCTTTATTGCATAGAAGGCCTTCCATTTGAATATGCTACATACAGAACTCTAAACTCTGAGCTTTTTATTCACAGAAAATGTGCTCTCATACATCTTTGTGTCCCCTGCCCTTAATACTATGCCCGACCCAGAGTCAGGGATCAAAAGATATTTTTGGTATGAATAGGCAAAAAGACACACATAGGACCTTGAATGACAGTGGCAATGTATTACAATTTATTAAAGATGTCTGATGAGTCCAGAGTACTCCAAATATTGAACCCAAATTCTCAAAAGGCATGTGATAGAATGGGGTTACCCTTGATAAACTATAAAGTTAGAAAGATTATTTTAGAGACACCATCAGAGTAGGTGTCAGAAAATCTGAGTTCCTGTCTAGCACATTCCACAAATAAAGTTTATAACATTGCACCAGTTGCTTAATCTCTGTGTCTTGAATCCTCATCAATAAAATTCAATTAAGTCTATTCAAACACTTCTGTGAATGCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAG
TGTACAGAGGAAAAGAAAGAGACACAAAAACTAGTGAAATCATACCTCCCCATGCATGGCTTTTAAACCAGTTCAACTGTGCTATAGGATACAATGGGGTGGTGGGGGCGGGGGGCATATGTACAATAATGTTTGCACCTTATCTAAATAAAATGCCACCAAGTTGATGTATTATTTAGCCTTTATTGCATAGAAGGCCTTCCATTTGAATATGCTACATACAGAACTCTAAACTCTGAGCTTTTTATTCACAGAAAATGTGCTCTCATACATCTTTGTGTCCCCTGCCCTTAATACTATGCCCGACCCAGAGTCAGGGATCAAAAGATATTTTTGGTATGAATAGGCAAAAAGACACACATAGGACCTTGAATGACAGTGGCAATGTATTACAATTTATTAAAGATGTCTGATGAGTCCAGAGTACTCCAAATATTGAACCCAAATTCTCAAAAGGCATGTGATAGAATGGGGTTACCCTTGATAAACTATAAAGTTAGAAAGATTATTTTAGAGACACCATCAGAGTAGGTGTCAGAAAATCTGAGTTCCTGTCTAGCACATTCCACAAATAAAGTTTATAACATTGCACCAGTTGCTTAATCTCTGTGTCTTGAATCCTCATCAATAAAATTCAATTAAGTCTATTCAAACACTTCTGTGAATGCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGGAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAG
Task1_train_20506
An alteration has been detected in ACTC1, GJD2-DT (actin alpha cardiac muscle 1| GJD2 divergent transcript) on Chromosome 15. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Dilated cardiomyopathy 1R
TGTACAGAGGAAAAGAAAGAGACACAAAAACTAGTGAAATCATACCTCCCCATGCATGGCTTTTAAACCAGTTCAACTGTGCTATAGGATACAATGGGGTGGTGGGGGCGGGGGGCATATGTACAATAATGTTTGCACCTTATCTAAATAAAATGCCACCAAGTTGATGTATTATTTAGCCTTTATTGCATAGAAGGCCTTCCATTTGAATATGCTACATACAGAACTCTAAACTCTGAGCTTTTTATTCACAGAAAATGTGCTCTCATACATCTTTGTGTCCCCTGCCCTTAATACTATGCCCGACCCAGAGTCAGGGATCAAAAGATATTTTTGGTATGAATAGGCAAAAAGACACACATAGGACCTTGAATGACAGTGGCAATGTATTACAATTTATTAAAGATGTCTGATGAGTCCAGAGTACTCCAAATATTGAACCCAAATTCTCAAAAGGCATGTGATAGAATGGGGTTACCCTTGATAAACTATAAAGTTAGAAAGATTATTTTAGAGACACCATCAGAGTAGGTGTCAGAAAATCTGAGTTCCTGTCTAGCACATTCCACAAATAAAGTTTATAACATTGCACCAGTTGCTTAATCTCTGTGTCTTGAATCCTCATCAATAAAATTCAATTAAGTCTATTCAAACACTTCTGTGAATGCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAG
TGTACAGAGGAAAAGAAAGAGACACAAAAACTAGTGAAATCATACCTCCCCATGCATGGCTTTTAAACCAGTTCAACTGTGCTATAGGATACAATGGGGTGGTGGGGGCGGGGGGCATATGTACAATAATGTTTGCACCTTATCTAAATAAAATGCCACCAAGTTGATGTATTATTTAGCCTTTATTGCATAGAAGGCCTTCCATTTGAATATGCTACATACAGAACTCTAAACTCTGAGCTTTTTATTCACAGAAAATGTGCTCTCATACATCTTTGTGTCCCCTGCCCTTAATACTATGCCCGACCCAGAGTCAGGGATCAAAAGATATTTTTGGTATGAATAGGCAAAAAGACACACATAGGACCTTGAATGACAGTGGCAATGTATTACAATTTATTAAAGATGTCTGATGAGTCCAGAGTACTCCAAATATTGAACCCAAATTCTCAAAAGGCATGTGATAGAATGGGGTTACCCTTGATAAACTATAAAGTTAGAAAGATTATTTTAGAGACACCATCAGAGTAGGTGTCAGAAAATCTGAGTTCCTGTCTAGCACATTCCACAAATAAAGTTTATAACATTGCACCAGTTGCTTAATCTCTGTGTCTTGAATCCTCATCAATAAAATTCAATTAAGTCTATTCAAACACTTCTGTGAATGCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGGAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAG
Task1_train_20507
A genetic alteration is present in ACTC1, GJD2-DT (actin alpha cardiac muscle 1| GJD2 divergent transcript) on Chromosome 15. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Hypertrophic cardiomyopathy 11
TGTACAGAGGAAAAGAAAGAGACACAAAAACTAGTGAAATCATACCTCCCCATGCATGGCTTTTAAACCAGTTCAACTGTGCTATAGGATACAATGGGGTGGTGGGGGCGGGGGGCATATGTACAATAATGTTTGCACCTTATCTAAATAAAATGCCACCAAGTTGATGTATTATTTAGCCTTTATTGCATAGAAGGCCTTCCATTTGAATATGCTACATACAGAACTCTAAACTCTGAGCTTTTTATTCACAGAAAATGTGCTCTCATACATCTTTGTGTCCCCTGCCCTTAATACTATGCCCGACCCAGAGTCAGGGATCAAAAGATATTTTTGGTATGAATAGGCAAAAAGACACACATAGGACCTTGAATGACAGTGGCAATGTATTACAATTTATTAAAGATGTCTGATGAGTCCAGAGTACTCCAAATATTGAACCCAAATTCTCAAAAGGCATGTGATAGAATGGGGTTACCCTTGATAAACTATAAAGTTAGAAAGATTATTTTAGAGACACCATCAGAGTAGGTGTCAGAAAATCTGAGTTCCTGTCTAGCACATTCCACAAATAAAGTTTATAACATTGCACCAGTTGCTTAATCTCTGTGTCTTGAATCCTCATCAATAAAATTCAATTAAGTCTATTCAAACACTTCTGTGAATGCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAG
TGTACAGAGGAAAAGAAAGAGACACAAAAACTAGTGAAATCATACCTCCCCATGCATGGCTTTTAAACCAGTTCAACTGTGCTATAGGATACAATGGGGTGGTGGGGGCGGGGGGCATATGTACAATAATGTTTGCACCTTATCTAAATAAAATGCCACCAAGTTGATGTATTATTTAGCCTTTATTGCATAGAAGGCCTTCCATTTGAATATGCTACATACAGAACTCTAAACTCTGAGCTTTTTATTCACAGAAAATGTGCTCTCATACATCTTTGTGTCCCCTGCCCTTAATACTATGCCCGACCCAGAGTCAGGGATCAAAAGATATTTTTGGTATGAATAGGCAAAAAGACACACATAGGACCTTGAATGACAGTGGCAATGTATTACAATTTATTAAAGATGTCTGATGAGTCCAGAGTACTCCAAATATTGAACCCAAATTCTCAAAAGGCATGTGATAGAATGGGGTTACCCTTGATAAACTATAAAGTTAGAAAGATTATTTTAGAGACACCATCAGAGTAGGTGTCAGAAAATCTGAGTTCCTGTCTAGCACATTCCACAAATAAAGTTTATAACATTGCACCAGTTGCTTAATCTCTGTGTCTTGAATCCTCATCAATAAAATTCAATTAAGTCTATTCAAACACTTCTGTGAATGCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGGAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAG
Task1_train_20508
Here is a variant affecting GJD2-DT, ACTC1 (GJD2 divergent transcript| actin alpha cardiac muscle 1) on Chromosome 15. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Atrial septal defect 5
GCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAG
GCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGAATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAG
Task1_train_20509
Assess the clinical impact of this variant on gene GJD2-DT, ACTC1 (GJD2 divergent transcript| actin alpha cardiac muscle 1), found on Chromosome 15. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Dilated cardiomyopathy 1R
GCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAG
GCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGAATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAG
Task1_train_20510
A mutation in GJD2-DT, ACTC1 (GJD2 divergent transcript| actin alpha cardiac muscle 1), located on Chromosome 15, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Hypertrophic cardiomyopathy 11
GCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAG
GCTAACAGTTCACTGGCAATTAATTTGAAAACAAAAATCTGTAAGGCTTCTGCAATCTAGTTGAAATCTACCTTTCCCAGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGAATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAG
Task1_train_20511
Consider this mutation in ACTC1, GJD2-DT (actin alpha cardiac muscle 1| GJD2 divergent transcript) on Chromosome 15. Is this a benign change or a disease-causing variant?
Pathogenic; not provided
AGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAGCATACAGGGATAGCACTGCCTGGATGGCCACGTACATGGCAGGGACATTGAAGGTCTCAAACATGATCTGAGTCATCT
AGTGGATTTTCTAAAATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAGGACCTCGCAGCCTTCAGTTCACTCAACCCAAGATCTCAAGATTTCAAAGAAACGAAGAGATTGAAGGCTTCTGTCTCGCAAGTTAGTCACTGATCAGGCAGAAGTGTTTGGCTCCTGCTTCCTCACATTTGTTTTGCACACACACAATGGTCTTGATATGTTTAGAGGGTATTTGCAATGGGATGTGGCTGGCCCAACTGTCAGCTAACCTTCATGTTTCTTTCATAGCCCCCAGGAAGAAAATTGAAGAGTTCAAAGAATTGAAAAGTTAAGCCAATTCATTTAAAATAATCTTTGACTTTCTCATTATCAATATATGTGTATTTTCTGCAAGGTTACAAAAACAACTGGAACATATGTTAAAATAATCTTCAGTGTCATCTGCAGCAACTAATTCTAGAGAACTATCTTATTCAATTTCATTTCTTACTTATATGGAACTAAACCTTAATCTGCTTTTCAGGTATGAAATATATTCATGATTCTGTCTCAAAATATGAAATCAAAAGTTAGCATTATAACTCCCAGCTAACTGTCATATTAATTCATCTGGATGAACCTTGTGGTACTGAACTTTGACAATGCTCAGGGTGTCAAAGCAAACACCTGCCCCACCCCACGCCTACCCCAAAAACAAACGAGAGGCTTTTATAGGTTGCAAGTCCTGGTCTGGTTTATTTATAAAGCAATAAATATTAGAAGCACAAACAAATTGCACGTGTGTAAACAAACTGTACAATGATTGATGAAAGATGAGGGAAGGTGGTTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCACACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAGCATACAGGGATAGCACTGCCTGGATGGCCACGTACATGGCAGGGACATTGAAGGTCTCAAACATGATCTGAGTCATCT
Task1_train_20512
Gene ACTC1, GJD2-DT (actin alpha cardiac muscle 1| GJD2 divergent transcript), found on Chromosome 15, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Cardiovascular phenotype
GCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAGCATACAGGGATAGCACTGCCTGGATGGCCACGTACATGGCAGGGACATTGAAGGTCTCAAACATGATCTGAGTCATCTTCTCCCGGTTGGCCTTGGGGTTCAGCGGGGCCTCTGTGAGCAGGGTGGGGTGCTCCTCGGGAGCCACACGGAGCTCATTGTAGAAGGTGTGGTGCCAGATCTTCTCCATGTCGTCCCAGTTGGTGATGATACCATGCTCGATGGGATACTTCAGGGTCAGGATGCCTCTCTTGCTCTGGGCTTCATCACCTACGTAGGAGTCCTTCTGACCCATACCCACCATAACTCCCTATGAGAAGAAAAAATGAGAAAATCATGCTCTCACCATGTCAGGAATATAATCAGTGTCTTGTCCATTTATATCTAACTGCCCAAGTCAAGGAACATATTTAAATACCAGAAATAACAAGCAATACGATTTTACCCCAATTTAGAAGAATTATTTAAAAATCAATCTTCTACCTTCTCCCCACTCCCCCAAAGATGTATAATTCTATTGTTGAGAATATAACTCAGGAGAGAATGAAGCTATTCCACTGAAGAAGCAGAGCCTCACCTCACCTTAAAAATATCATATGCCTTCATTAAGTTATTAAGCTCATCACCCATGTCAACTGGAATATAGATGACTGCATTTTGGAATGACTGAATTAATGACACATTGTATTTCTCCTAAGAAAAAGATTTTGACATTCAAGTGAACACATAATGATGGGCTGATATGCCATCCTCACTCCAACAGTGAAATTCAGCCTGTCCAGAGCTGTTCTGGAGTCATTCACCAGCTCTGAGGACTAAGCTCTCCTGCTTGGCAGCCTGTCTGGCCAGGCATGTGACAAACCCAGAGAGCATGGCATGTCTTTTAACAAACGAGGTGGTATGTCACTATCACCATGGCACTTGCTGCCTCTGTCACGCCTGGCTTCTAAAAATGCAACAGCCAGGAAGGAGATAGATTGATTACACCTTTGGGGAACCCTGTAAACTGGCTGTGAACATGAGAGAGGAATGTGGATTTGGTCCTGGTTGGTTGGGAGAGGTGATATTGTTAGAAGTTTTAAACAGGACTGAAAAGAGAGGACAAGGAAGAAAATGAAGTGTATAAGGCAGAGAAGACACTAAAGACTAAAAGTCCAAAAGGCCATTAGTGGAGAGAAGCAGGTGGCTTTCACACCAGGGAGTGGGACCCTTTTAGAGGCGTGCCACTCAGGTGTACATTCCTCAGTATGTTGGGGTTTTGTGGAGTATTGCTTGCCTTGGCTTGGATTTGAAGTCAATCAGCCTTCTCTTAATTT
GCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTATAATGTGGGATATGTCATACCACGAAATAATGTGGCCAATCAAGTTATATGAACTCACCTCTATTTCATCATTTATATTATTAAAGATATATTCTATTATTAAAATGGAATTTCTCCACTTACCTAGAGTGTAATTTGGCAACAAGCTAAATGTGTAGTGGAGCCTAGCCCAAAAGTTGGGAGCTTTAAAAATGTATTCAAAGATTTTGTTGCGTGTGTGTGTGTCTTTTTTTTGTCAAAGATTTATTTTTATTCACTGCTTAAAAGCATTTTGGAAGTTACCTATCTTGGGAAAAGTGCTAAGAAAATCAGAAAAAGTGGTAGAAAAGCTAACAGGTAAAGTTTGTAGGAGACAAGAAACTGAGTATGAGGGAAAAGGAATTTGGAACGTAGTTCTGCTTAGAATACCAAGACTTGCCTCGGATCTCCCACTCACAAAAGTTCTTTACCTTAATCTTCATGGTGCTAGGAGCCAGAGCAGTGATTTCCTTCTGCATACGATCAGCAATACCAGGGTACATAGTGGTGCCTCCAGATAAGACATTGTTGGCATACAGGTCCTTGCGGATATCAATGTCACACTTCATGATGCTATTGTAAGTTGTTTCATGGATGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGCGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAGCATACAGGGATAGCACTGCCTGGATGGCCACGTACATGGCAGGGACATTGAAGGTCTCAAACATGATCTGAGTCATCTTCTCCCGGTTGGCCTTGGGGTTCAGCGGGGCCTCTGTGAGCAGGGTGGGGTGCTCCTCGGGAGCCACACGGAGCTCATTGTAGAAGGTGTGGTGCCAGATCTTCTCCATGTCGTCCCAGTTGGTGATGATACCATGCTCGATGGGATACTTCAGGGTCAGGATGCCTCTCTTGCTCTGGGCTTCATCACCTACGTAGGAGTCCTTCTGACCCATACCCACCATAACTCCCTATGAGAAGAAAAAATGAGAAAATCATGCTCTCACCATGTCAGGAATATAATCAGTGTCTTGTCCATTTATATCTAACTGCCCAAGTCAAGGAACATATTTAAATACCAGAAATAACAAGCAATACGATTTTACCCCAATTTAGAAGAATTATTTAAAAATCAATCTTCTACCTTCTCCCCACTCCCCCAAAGATGTATAATTCTATTGTTGAGAATATAACTCAGGAGAGAATGAAGCTATTCCACTGAAGAAGCAGAGCCTCACCTCACCTTAAAAATATCATATGCCTTCATTAAGTTATTAAGCTCATCACCCATGTCAACTGGAATATAGATGACTGCATTTTGGAATGACTGAATTAATGACACATTGTATTTCTCCTAAGAAAAAGATTTTGACATTCAAGTGAACACATAATGATGGGCTGATATGCCATCCTCACTCCAACAGTGAAATTCAGCCTGTCCAGAGCTGTTCTGGAGTCATTCACCAGCTCTGAGGACTAAGCTCTCCTGCTTGGCAGCCTGTCTGGCCAGGCATGTGACAAACCCAGAGAGCATGGCATGTCTTTTAACAAACGAGGTGGTATGTCACTATCACCATGGCACTTGCTGCCTCTGTCACGCCTGGCTTCTAAAAATGCAACAGCCAGGAAGGAGATAGATTGATTACACCTTTGGGGAACCCTGTAAACTGGCTGTGAACATGAGAGAGGAATGTGGATTTGGTCCTGGTTGGTTGGGAGAGGTGATATTGTTAGAAGTTTTAAACAGGACTGAAAAGAGAGGACAAGGAAGAAAATGAAGTGTATAAGGCAGAGAAGACACTAAAGACTAAAAGTCCAAAAGGCCATTAGTGGAGAGAAGCAGGTGGCTTTCACACCAGGGAGTGGGACCCTTTTAGAGGCGTGCCACTCAGGTGTACATTCCTCAGTATGTTGGGGTTTTGTGGAGTATTGCTTGCCTTGGCTTGGATTTGAAGTCAATCAGCCTTCTCTTAATTT
Task1_train_20513
A genomic change on Chromosome 15 affects ACTC1, GJD2-DT (actin alpha cardiac muscle 1| GJD2 divergent transcript). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Atrial septal defect 5
TGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAGCATACAGGGATAGCACTGCCTGGATGGCCACGTACATGGCAGGGACATTGAAGGTCTCAAACATGATCTGAGTCATCTTCTCCCGGTTGGCCTTGGGGTTCAGCGGGGCCTCTGTGAGCAGGGTGGGGTGCTCCTCGGGAGCCACACGGAGCTCATTGTAGAAGGTGTGGTGCCAGATCTTCTCCATGTCGTCCCAGTTGGTGATGATACCATGCTCGATGGGATACTTCAGGGTCAGGATGCCTCTCTTGCTCTGGGCTTCATCACCTACGTAGGAGTCCTTCTGACCCATACCCACCATAACTCCCTATGAGAAGAAAAAATGAGAAAATCATGCTCTCACCATGTCAGGAATATAATCAGTGTCTTGTCCATTTATATCTAACTGCCCAAGTCAAGGAACATATTTAAATACCAGAAATAACAAGCAATACGATTTTACCCCAATTTAGAAGAATTATTTAAAAATCAATCTTCTACCTTCTCCCCACTCCCCCAAAGATGTATAATTCTATTGTTGAGAATATAACTCAGGAGAGAATGAAGCTATTCCACTGAAGAAGCAGAGCCTCACCTCACCTTAAAAATATCATATGCCTTCATTAAGTTATTAAGCTCATCACCCATGTCAACTGGAATATAGATGACTGCATTTTGGAATGACTGAATTAATGACACATTGTATTTCTCCTAAGAAAAAGATTTTGACATTCAAGTGAACACATAATGATGGGCTGATATGCCATCCTCACTCCAACAGTGAAATTCAGCCTGTCCAGAGCTGTTCTGGAGTCATTCACCAGCTCTGAGGACTAAGCTCTCCTGCTTGGCAGCCTGTCTGGCCAGGCATGTGACAAACCCAGAGAGCATGGCATGTCTTTTAACAAACGAGGTGGTATGTCACTATCACCATGGCACTTGCTGCCTCTGTCACGCCTGGCTTCTAAAAATGCAACAGCCAGGAAGGAGATAGATTGATTACACCTTTGGGGAACCCTGTAAACTGGCTGTGAACATGAGAGAGGAATGTGGATTTGGTCCTGGTTGGTTGGGAGAGGTGATATTGTTAGAAGTTTTAAACAGGACTGAAAAGAGAGGACAAGGAAGAAAATGAAGTGTATAAGGCAGAGAAGACACTAAAGACTAAAAGTCCAAAAGGCCATTAGTGGAGAGAAGCAGGTGGCTTTCACACCAGGGAGTGGGACCCTTTTAGAGGCGTGCCACTCAGGTGTACATTCCTCAGTATGTTGGGGTTTTGTGGAGTATTGCTTGCCTTGGCTTGGATTTGAAGTCAATCAGCCTTCTCTTAATTTGGCCTAAAGAGTTCATCGAACAAGAGGGTCAGGTGAGAGCCATTTCCTAGATCGCTGGACTGAAGGGGTCCCGAGTGGGACGGGGGGCTCGGCGGGAAGTTTACCTGGTGCCGCGGGCGGCCCACGATGGACGGGAAGACAGCGCGGGGCGCGTCATCGCCCGCAAAGCCGGCCTTCACCAGCCCAGAGCCGTTGTCGCACACCAGGGCGGTGGTCTCCTCGTCGTCACACATCTTGGCACAGCTTCAGGGGGTTCTGCAGGTTGAGGAGGGGAGGGCGGACCACGCTTAGCTGCCTGTGCAGCTGGCCTTCTCCGCACCCAGAGGACAGGACAGAGCAGAAGGGGGTTGTGGGGACTGGACAGGGGGTTGGGCGGGGAACACTCCTGCCACCTCCCTTCCCCTCGAATCATAAAAGGGAGGGAAGAAGCCGCGGAGGAGACTGGGGACAGAGAAGGGCAGAGGAATCCACCCAGGCTCCCTGGCCAGGAGTTCCAGCTAGGGTGCCAGGTGCAAGGAGGGACCCAAGAAACCCAGCCCCTTAGTCCTCCCCAGCCCTTTAACTTTCTTCCTTTTCACGAACTGGGAACTCGATCTCCAGCCCTGTCCATATCGCCATGCCTGTGCCCCAGATGGAGGGGAAAGCGCACGAGAGTAGGGACCCAAAAGCCCCTTGGGGAGCCACAAAATTCCCCTTCTTAGAGCCCCTGCGAGGTCCTGCGAGGACCAACGCCCAGGACAAAACAAGTTAGAACCAAATCAAAAAGTGTGGGCTTTAAAAAAAAAAAAAAAAAGGCAG
TGCCAGCAGATTCCATACCTGGGAACGAGTCACACACACACACACACACACACACACACACACACACACACACACATCACAGTGCATTCAGGTCAAGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTTGTTGACATATAAGTGCCCAGTTATTAATATGAGTAGGAATGTTATTGCATTTAATGATGAGGAACTTGGAAAGTCCAGCTACTTGGTAGTGAAACTTACGGGAATAAGTCAGCTCTTGTGAACTAGCCCTTTTCCTGCAGATACGTGCTATTCAGTTACTACTCTGTGTCATCCTTTATTTTGAGATGAACTCAGTGTGTCATCCTTTATTATATCACTAGAGCAGAACATAGACTTCCCCTTTAATGAGCCATCAGGACTTGAGGTTGAGCTGTGTGGGAATCCAAACTATGACTTCTTTTAACTCAAGGGCTTCTTGAGCCTTCTAGATTTTACTCTGGGAGACCCTAAGATTTCCAGGGAAAATCGTGCCTCTGCACCAGACCCTACAACTCACCAATGAAGGAGGGCTGGAAGAGTGTCTCAGGACAGCGGAAGCGCTCATTGCCAATAGTGATGACTTGGCCATCAGGCAGTTCATAGCTCTTCTCCAGGGAGGAGGAAGAGGCAGCTGTGGCCATCTCATTCTCAAAATCCAGGGCGACATAGCACAGCTTCTCTTTAATGTCACGGACAATTTCACGTTCAGCTACAGAAATAAAGAGTATCACAGTCATGCTCTGAAGCAAGAAGTCAATTATAGGGAGGTAGGCGGATTCAGTGAGAGAGGAGGAAAGCAGACCCACACTGTGGCAGATGAGACACACACACTCACCAGTGGTGACAAAGGAGTAGCCACGCTCAGTGAGGATCTTCATGAGGTAGTCAGTGAGGTCCCGACCAGCCAGATCCAGACGCATGATGGCATGGGGCAAAGCGTAGCCCTCATAGATGGGGACATTGTGAGTTACACCATCCCCAGAGTCCAGAACAATGCCTGCCCGGGGAAGTAGACAAGAACAAGGTAAATTCCTGAGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATTCTCCTTGGGGATGCTTGCCCAGGTGATGTGATGGTTTAAACACATAACAATGACTGCTGCACTCCAAGCTGCTACACTGCGCTGAGCTTTAAATGAGGGAAGGACCTATCTCCACAAGCTATCAGCTCCAACAATAATTGTGCTCCGAAACTAACCTCAGGGCACTACTGTTAACTCTTTCTCTTAGCACAGACCTTGCTAGGGAATGGGAGGAAAGGGATTATCCCTTTTTCAACTGGGGGATCTGATTCACAGCAAGGTCGGTGACTTGGGAATGTGATTCATCAGTAACTGTCCCCAGAGCCCAGCATACCTGTGGTACGGCCAGAAGCATACAGGGATAGCACTGCCTGGATGGCCACGTACATGGCAGGGACATTGAAGGTCTCAAACACGATCTGAGTCATCTTCTCCCGGTTGGCCTTGGGGTTCAGCGGGGCCTCTGTGAGCAGGGTGGGGTGCTCCTCGGGAGCCACACGGAGCTCATTGTAGAAGGTGTGGTGCCAGATCTTCTCCATGTCGTCCCAGTTGGTGATGATACCATGCTCGATGGGATACTTCAGGGTCAGGATGCCTCTCTTGCTCTGGGCTTCATCACCTACGTAGGAGTCCTTCTGACCCATACCCACCATAACTCCCTATGAGAAGAAAAAATGAGAAAATCATGCTCTCACCATGTCAGGAATATAATCAGTGTCTTGTCCATTTATATCTAACTGCCCAAGTCAAGGAACATATTTAAATACCAGAAATAACAAGCAATACGATTTTACCCCAATTTAGAAGAATTATTTAAAAATCAATCTTCTACCTTCTCCCCACTCCCCCAAAGATGTATAATTCTATTGTTGAGAATATAACTCAGGAGAGAATGAAGCTATTCCACTGAAGAAGCAGAGCCTCACCTCACCTTAAAAATATCATATGCCTTCATTAAGTTATTAAGCTCATCACCCATGTCAACTGGAATATAGATGACTGCATTTTGGAATGACTGAATTAATGACACATTGTATTTCTCCTAAGAAAAAGATTTTGACATTCAAGTGAACACATAATGATGGGCTGATATGCCATCCTCACTCCAACAGTGAAATTCAGCCTGTCCAGAGCTGTTCTGGAGTCATTCACCAGCTCTGAGGACTAAGCTCTCCTGCTTGGCAGCCTGTCTGGCCAGGCATGTGACAAACCCAGAGAGCATGGCATGTCTTTTAACAAACGAGGTGGTATGTCACTATCACCATGGCACTTGCTGCCTCTGTCACGCCTGGCTTCTAAAAATGCAACAGCCAGGAAGGAGATAGATTGATTACACCTTTGGGGAACCCTGTAAACTGGCTGTGAACATGAGAGAGGAATGTGGATTTGGTCCTGGTTGGTTGGGAGAGGTGATATTGTTAGAAGTTTTAAACAGGACTGAAAAGAGAGGACAAGGAAGAAAATGAAGTGTATAAGGCAGAGAAGACACTAAAGACTAAAAGTCCAAAAGGCCATTAGTGGAGAGAAGCAGGTGGCTTTCACACCAGGGAGTGGGACCCTTTTAGAGGCGTGCCACTCAGGTGTACATTCCTCAGTATGTTGGGGTTTTGTGGAGTATTGCTTGCCTTGGCTTGGATTTGAAGTCAATCAGCCTTCTCTTAATTTGGCCTAAAGAGTTCATCGAACAAGAGGGTCAGGTGAGAGCCATTTCCTAGATCGCTGGACTGAAGGGGTCCCGAGTGGGACGGGGGGCTCGGCGGGAAGTTTACCTGGTGCCGCGGGCGGCCCACGATGGACGGGAAGACAGCGCGGGGCGCGTCATCGCCCGCAAAGCCGGCCTTCACCAGCCCAGAGCCGTTGTCGCACACCAGGGCGGTGGTCTCCTCGTCGTCACACATCTTGGCACAGCTTCAGGGGGTTCTGCAGGTTGAGGAGGGGAGGGCGGACCACGCTTAGCTGCCTGTGCAGCTGGCCTTCTCCGCACCCAGAGGACAGGACAGAGCAGAAGGGGGTTGTGGGGACTGGACAGGGGGTTGGGCGGGGAACACTCCTGCCACCTCCCTTCCCCTCGAATCATAAAAGGGAGGGAAGAAGCCGCGGAGGAGACTGGGGACAGAGAAGGGCAGAGGAATCCACCCAGGCTCCCTGGCCAGGAGTTCCAGCTAGGGTGCCAGGTGCAAGGAGGGACCCAAGAAACCCAGCCCCTTAGTCCTCCCCAGCCCTTTAACTTTCTTCCTTTTCACGAACTGGGAACTCGATCTCCAGCCCTGTCCATATCGCCATGCCTGTGCCCCAGATGGAGGGGAAAGCGCACGAGAGTAGGGACCCAAAAGCCCCTTGGGGAGCCACAAAATTCCCCTTCTTAGAGCCCCTGCGAGGTCCTGCGAGGACCAACGCCCAGGACAAAACAAGTTAGAACCAAATCAAAAAGTGTGGGCTTTAAAAAAAAAAAAAAAAAGGCAG
Task1_train_20514
This sequence variant lies in MEIS2 (Meis homeobox 2) on Chromosome 15. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Cardiac malformation, cleft lip/palate, microcephaly, and digital anomalies
GGGCAAGGAAAAATAAAATGGGGGCAAATTATAAAAAATAAAATAAAGTCTCTGAAGTGATAGTGAAGACAGATCGCACCCGACTGTACTTACTTCCCCCTTGCTTTGCGATTGCTTTACATGATGAAGGTTACATGTAGTGCCATTGCCCATCCATGCCCATATTCATGCCCATTCCACTCATAGGTCCTAGAAAGGAGATAAAATCCAAGAAGAGGCCGGAAAATCAGCAATAATTGATGGTGAAAAAATAGAAGGAAACTCAGATTCCTTTTCACTTATTGCCTTGGTTTAAAAAGAAAAAAGAAAAAGGATGTGTATGGGGCAGAGTATAATGGTACTGTGGTAAAATCTTTACTTTTTCAAAGAGGAATTTTTTCCCCCACCCAATGTAAAGAAAGCAGGCAGAGCAGGCAGCAGGCAAATGTTAAACCCACCATGACAGTGGGATAGTAGAGTGGATGGAGAGGCTGGTGGAGCAGGTGGCACTTCCCAGGGAAGCCCAGAGGCGGGATGAGCCAACCTACCTGCAGGCCGGATCCCCATGTGTTGCTGACCATCCAACACAAAGCTCCCCATGGGCTGACCCTCTGGACTATATGCTGCTCCTTGGCTCACTGAAGGATCAAGAAGAAAACCTGATTGTGGTCATTCGAGGACACAGAGGAGAAAGAAGAAAAGATATACCAAACAATCAGCAATTGTTCCCGCTGCAGCACTGAAACGTTATAGCAACAATGTGGTTGGCACTCTACAAATGGGGGTGTGGTTTGTCTGAGTGTCTTGATGACTGAGTGAAGGTGTGTGAGTAGCTTTAAAAATGTTCTGGAAGAAAGACTTCACTGGCCAGTTTCCCAGGGGGTTCGTCCTCTGCAGCCCTTGCTTTTTTACTTATCTCTTGATTAGGGGGACGAAGGCTGGAGAAGTTAGGGGTACCCCATATACAAATATTGCAATGTACCATTTGGTTGGGATTCTCTGAGGCTGCCATCTCTGGTGGCTTAATACAAAATGTTCATATTTTACACAAACATTTTAAACCTGAATACAATTTCACAAGGTTAAATAGACTCAATTAAAAGCTTGCCTTTTTATTCACACCAAGGAAATATAAACTTAGTAAATATAATATTTCCATTGTTTTATGTTCTTCTCCCTAGCCTCCAATAGTGGGAACATATTTTGGCGTTATTGGGGAAATTTTGCCAAAGGATGACTAATTTTCACAAATCCTTTAAAGCGAGGCCACAGGTAAAATCTCCATCAAGTTTAACACCGTTGTTAGTGGCAGCAGTCATCACCCCAAGGAAAACTGTTTTTCCCTATAAGCCTTATTGCAGGAGACCACAAACCCTCAGTAAACTGAGGAAATGTCTGTTTCAAAATAAAACGACTTGGAGTATACCAGGAGGGTTCTGATAGTACCATACAAAAACTGTTTTAGAGAAATTGAGAGAATTCTGAGAAAAGCTCACATGTATTTTAGCAGCATGGATGTGAAGCATTTTATACAAAGGTAATATTCTTTAATAAAAAATAATGGTGGCAATGCAGCAAGTCAGGCTTTAATAGGATATTATGAATAGCCAAAGCAAATGAATGGATACAATAAGTTTAACAGCAGATGCTACAGAAAGGAAAGCCTAGCATACACCAAGGAGCTGTGGGTAACAGAAAAATGAGAGTGTGCTAATGATTGGATGCAGACAAGCAAGGGGTAATGCCAGAGCTCACAAACACGCTGCTTGTGGCATTAATACCTGTGCCCAATTACCAATTCAGAAAGAAAATAAAAAGCAGTGTCAGTAGAGTCAGGGTGGGAAATCTCCAATTAGCACCACTTACTGAAGTTGCTTCCTTGAGTGGGATTCTGGGGACATTAAAAAAAAAAATCCAGAATGCCTGGTGGAAGCACTTATTTATCAGATGAGGAAACTACTGGAGTATAACTTGATGAGGATTTGTGCCTGTGGGACATAAATATAGATACTACTTGGAACTTGCCTGCTCGATTTGACTGGTCAATCATGGGCTGTACTATTCTTCTTCTGGCATTAATAAACCTGAAAGAGAACAGAGAAGTCCAGTCATCATACTCCGTTTCTGTACTCTGCGAACACCTTTGCATGAATGCTGAGGAGCACAAAATACAGTCAAATCTCTTCTGAAAATTATCTTTTCAATTTAAAGGTGATTTTCCCTTTCAGCGTTCAAAAATAGTTGACTGGGTAATCTCCGTCGTCACTGCGTAGTCAACTCCAAAACAACTTGCTAGAAGAGCTCAGGGACGGAATAAAGTTCTCCATGAGAAAGCTTCTATTAACTTCAAATTGTGCTTCTGCTTCTTGCACAAGTAGGAATCTGGTTAAAGTTCACAGGCTGGAAGACTTTCCCCCTTTCCCTAGACTCCCCGTGATAGGGAGACCCAGCTTCCCCTTGCAGCTGGTCATAAATGGAGACCAGGCTCTAGCACTCGGCTTTCACAAGGTATTGTTAGGTCAGCAAAGCCATCAATTAGGCTGTCTGAAGTTTTATCACCAACACAGCAGTAATAAGTGCTGGCCAGAAAGACTTCTGCTCTTCGGCAACTCCTGCAGTTTAAGCCTGTAAAGTTAGGGGTCATTCAGAGGTCAGTGCCAGCTGGGGGCAGCCTTTCCAGCCTAAGCTGGGACACCCAGGGCAGAGGATAAGGTAACTGCCAACCATAAACCCAGCCACCTTTCAACCCACTAGAAAGACAGAGCCTCAGGTACACATGTTTGATATTAGAGCTCAAGAAACGTTTGCAAATCAGGTGGTGGCTGAATCGCAGGAATGCAAAGGAGAAGCAGTTATTTCATCTAAGAAGCCTGGATCTAATTTTGTTGGAAATCCAAAAATAAGTGCCTACTTCATGTTACTTTAATGTTTAATAATGCCCATCAAATATTCATGTACAAACAGAGTAAGATGATAAGAAATCTCCTTTATTTCTCCAAATTTAATAAAAACAAAACAATTTTCTACCATTTGTGAGTTACCCTTGTCCCTGTGCACTTAACGACGTGTATTCCCCACACATTTGAGCTCATGCACACGATTCACTGACCACGCATTTCGGAGGAGCAGGGAGCATCCAGCTAGCTTCTCCCTAAAAATATACCCATTGATAACATCTGTCAATATTTCCAGTTTCAGATCTTAAGCACAGGGGGACTTCATGATTAATGAGTCCACCTGGGGCCACAGGCAGGAACTGAAAACTCACTCTTTGAAATTAGCCAGAAAAATTCAGTGTGTGCTGGCAGCTCTGTGTTCCGAGGAAGCTGAAGTCCCTTTGGAGGAGGACAGTCAGGCCCCACTCGGTCGGGCCTCCTGTGAGCACTCTGGTGGGAATACAATTAAGCTGAGGAATAATAGCTGGGAGAAAACCAAAGGAGTCTTTTGCATATGGTGTTTGTTTGCAAAACAATGGACTTCTTTATTACTTAAGAAAGTGTAGCTCAGTTGTCAAAAAAGAAAGTGATCAGCTATGTAGAGGTGAAAACAAAAGGAGAGTTGAAACTGCATCTTTCTTCCCACCTGTCACCTGAAATGTTGCTGAGGAATGAATATCTGACTAGATCACAAAGACTTCCAGAAGCATCCCTCCTCCAATCAGAAAAAGAACTTAATTATCTACTCTTTCCCCACCACTTTTACAGCAACCAAGGAGGACTGACCTGATATTTCCACCCCAGGAACCGTTTTTATCAGCTCACCTTGAAACCAGCAGAGATGCTCAGGAGGGTCAGAGAAGGCTCTTCTCCTTGAAGTTTCTAATAGAGGACAACACTCGGCAGGGGTTTTACCCCCTTTTATGTGCTACTAATCCTGGTTTTTGTGTTTTGCGTTTTTTATTTTTATTTTTTTTTCGGTATAGGCTAACTCTTCGGGTAAAACGAATTGCTATTTTTTTCCCTTTTTAATTTCACTCTTTTATTCTTTACATCTGGAGGTTGTTCCCTTATTTATGTCTTTCTCTCCAGTTCCCCCAAACACTCCCTTACTCACAGAGCTGCAAGGCATCATGGTTCTTAGTTCTCAGCAGGAGAACTCCACACTGTCTTCAAACAAA
GGGCAAGGAAAAATAAAATGGGGGCAAATTATAAAAAATAAAATAAAGTCTCTGAAGTGATAGTGAAGACAGATCGCACCCGACTGTACTTACTTCCCCCTTGCTTTGCGATTGCTTTACATGATGAAGGTTACATGTAGTGCCATTGCCCATCCATGCCCATATTCATGCCCATTCCACTCATAGGTCCTAGAAAGGAGATAAAATCCAAGAAGAGGCCGGAAAATCAGCAATAATTGATGGTGAAAAAATAGAAGGAAACTCAGATTCCTTTTCACTTATTGCCTTGGTTTAAAAAGAAAAAAGAAAAAGGATGTGTATGGGGCAGAGTATAATGGTACTGTGGTAAAATCTTTACTTTTTCAAAGAGGAATTTTTTCCCCCACCCAATGTAAAGAAAGCAGGCAGAGCAGGCAGCAGGCAAATGTTAAACCCACCATGACAGTGGGATAGTAGAGTGGATGGAGAGGCTGGTGGAGCAGGTGGCACTTCCCAGGGAAGCCCAGAGGCGGGATGAGCCAACCTACCTGCAGGCCGGATCCCCATGTGTTGCTGACCATCCAACACAAAGCTCCCCATGGGCTGACCCTCTGGACTATATGCTGCTCCTTGGCTCACTGAAGGATCAAGAAGAAAACCTGATTGTGGTCATTCGAGGACACAGAGGAGAAAGAAGAAAAGATATACCAAACAATCAGCAATTGTTCCCGCTGCAGCACTGAAACGTTATAGCAACAATGTGGTTGGCACTCTACAAATGGGGGTGTGGTTTGTCTGAGTGTCTTGATGACTGAGTGAAGGTGTGTGAGTAGCTTTAAAAATGTTCTGGAAGAAAGACTTCACTGGCCAGTTTCCCAGGGGGTTCGTCCTCTGCAGCCCTTGCTTTTTTACTTATCTCTTGATTAGGGGGACGAAGGCTGGAGAAGTTAGGGGTACCCCATATACAAATATTGCAATGTACCATTTGGTTGGGATTCTCTGAGGCTGCCATCTCTGGTGGCTTAATACAAAATGTTCATATTTTACACAAACATTTTAAACCTGAATACAATTTCACAAGGTTAAATAGACTCAATTAAAAGCTTGCCTTTTTATTCACACCAAGGAAATATAAACTTAGTAAATATAATATTTCCATTGTTTTATGTTCTTCTCCCTAGCCTCCAATAGTGGGAACATATTTTGGCGTTATTGGGGAAATTTTGCCAAAGGATGACTAATTTTCACAAATCCTTTAAAGCGAGGCCACAGGTAAAATCTCCATCAAGTTTAACACCGTTGTTAGTGGCAGCAGTCATCACCCCAAGGAAAACTGTTTTTCCCTATAAGCCTTATTGCAGGAGACCACAAACCCTCAGTAAACTGAGGAAATGTCTGTTTCAAAATAAAACGACTTGGAGTATACCAGGAGGGTTCTGATAGTACCATACAAAAACTGTTTTAGAGAAATTGAGAGAATTCTGAGAAAAGCTCACATGTATTTTAGCAGCATGGATGTGAAGCATTTTATACAAAGGTAATATTCTTTAATAAAAAATAATGGTGGCAATGCAGCAAGTCAGGCTTTAATAGGATATTATGAATAGCCAAAGCAAATGAATGGATACAATAAGTTTAACAGCAGATGCTACAGAAAGGAAAGCCTAGCATACACCAAGGAGCTGTGGGTAACAGAAAAATGAGAGTGTGCTAATGATTGGATGCAGACAAGCAAGGGGTAATGCCAGAGCTCACAAACACGCTGCTTGTGGCATTAATACCTGTGCCCAATTACCAATTCAGAAAGAAAATAAAAAGCAGTGTCAGTAGAGTCAGGGTGGGAAATCTCCAATTAGCACCACTTACTGAAGTTGCTTCCTTGAGTGGGATTCTGGGGACATTAAAAAAAAAAATCCAGAATGCCTGGTGGAAGCACTTATTTATCAGATGAGGAAACTACTGGAGTATAACTTGATGAGGATTTGTGCCTGTGGGACATAAATATAGATACTACTTGGAACTTGCCTGCTCGATTTGACTGGTCAATCATGGGCTGTACTATTCTTCTTTTGGCATTAATAAACCTGAAAGAGAACAGAGAAGTCCAGTCATCATACTCCGTTTCTGTACTCTGCGAACACCTTTGCATGAATGCTGAGGAGCACAAAATACAGTCAAATCTCTTCTGAAAATTATCTTTTCAATTTAAAGGTGATTTTCCCTTTCAGCGTTCAAAAATAGTTGACTGGGTAATCTCCGTCGTCACTGCGTAGTCAACTCCAAAACAACTTGCTAGAAGAGCTCAGGGACGGAATAAAGTTCTCCATGAGAAAGCTTCTATTAACTTCAAATTGTGCTTCTGCTTCTTGCACAAGTAGGAATCTGGTTAAAGTTCACAGGCTGGAAGACTTTCCCCCTTTCCCTAGACTCCCCGTGATAGGGAGACCCAGCTTCCCCTTGCAGCTGGTCATAAATGGAGACCAGGCTCTAGCACTCGGCTTTCACAAGGTATTGTTAGGTCAGCAAAGCCATCAATTAGGCTGTCTGAAGTTTTATCACCAACACAGCAGTAATAAGTGCTGGCCAGAAAGACTTCTGCTCTTCGGCAACTCCTGCAGTTTAAGCCTGTAAAGTTAGGGGTCATTCAGAGGTCAGTGCCAGCTGGGGGCAGCCTTTCCAGCCTAAGCTGGGACACCCAGGGCAGAGGATAAGGTAACTGCCAACCATAAACCCAGCCACCTTTCAACCCACTAGAAAGACAGAGCCTCAGGTACACATGTTTGATATTAGAGCTCAAGAAACGTTTGCAAATCAGGTGGTGGCTGAATCGCAGGAATGCAAAGGAGAAGCAGTTATTTCATCTAAGAAGCCTGGATCTAATTTTGTTGGAAATCCAAAAATAAGTGCCTACTTCATGTTACTTTAATGTTTAATAATGCCCATCAAATATTCATGTACAAACAGAGTAAGATGATAAGAAATCTCCTTTATTTCTCCAAATTTAATAAAAACAAAACAATTTTCTACCATTTGTGAGTTACCCTTGTCCCTGTGCACTTAACGACGTGTATTCCCCACACATTTGAGCTCATGCACACGATTCACTGACCACGCATTTCGGAGGAGCAGGGAGCATCCAGCTAGCTTCTCCCTAAAAATATACCCATTGATAACATCTGTCAATATTTCCAGTTTCAGATCTTAAGCACAGGGGGACTTCATGATTAATGAGTCCACCTGGGGCCACAGGCAGGAACTGAAAACTCACTCTTTGAAATTAGCCAGAAAAATTCAGTGTGTGCTGGCAGCTCTGTGTTCCGAGGAAGCTGAAGTCCCTTTGGAGGAGGACAGTCAGGCCCCACTCGGTCGGGCCTCCTGTGAGCACTCTGGTGGGAATACAATTAAGCTGAGGAATAATAGCTGGGAGAAAACCAAAGGAGTCTTTTGCATATGGTGTTTGTTTGCAAAACAATGGACTTCTTTATTACTTAAGAAAGTGTAGCTCAGTTGTCAAAAAAGAAAGTGATCAGCTATGTAGAGGTGAAAACAAAAGGAGAGTTGAAACTGCATCTTTCTTCCCACCTGTCACCTGAAATGTTGCTGAGGAATGAATATCTGACTAGATCACAAAGACTTCCAGAAGCATCCCTCCTCCAATCAGAAAAAGAACTTAATTATCTACTCTTTCCCCACCACTTTTACAGCAACCAAGGAGGACTGACCTGATATTTCCACCCCAGGAACCGTTTTTATCAGCTCACCTTGAAACCAGCAGAGATGCTCAGGAGGGTCAGAGAAGGCTCTTCTCCTTGAAGTTTCTAATAGAGGACAACACTCGGCAGGGGTTTTACCCCCTTTTATGTGCTACTAATCCTGGTTTTTGTGTTTTGCGTTTTTTATTTTTATTTTTTTTTCGGTATAGGCTAACTCTTCGGGTAAAACGAATTGCTATTTTTTTCCCTTTTTAATTTCACTCTTTTATTCTTTACATCTGGAGGTTGTTCCCTTATTTATGTCTTTCTCTCCAGTTCCCCCAAACACTCCCTTACTCACAGAGCTGCAAGGCATCATGGTTCTTAGTTCTCAGCAGGAGAACTCCACACTGTCTTCAAACAAA
Task1_train_20515
The gene SPRED1 (sprouty related EVH1 domain containing 1) on Chromosome 15 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Legius syndrome
TTAGGCTCCAGCCCGCAACCCCAGTAGGTTTCTGTGCAAAAATCTTTTGAGATGAATGCATACTTTGTCTTCTAACAATGCATTCGTGACAGCTGTCTATCCAATCGGTCCGCCTCCGTTCAGAGCAGTTCGTGCCACAGAAGCATCTCCTGCGCTATAGTTATGCAACCTCACTCGCAGCGGGAGTTATTTCCTCCGTTCTGGCTGCGCCAGATTCATGTAACACGCCTACCCTGGGCTTCAATGGAAGTCGTTCTCCATTAACAATCACTCCAGCTTTCCGAGATGAATGCCCTGATAGCATACCCCTTGCGCAGTAAGAATCCAGGCAGCGAGGCGAGGTGTTAAAACACACATACATTCTCATATTCTCTCTCTCTCTCTCTCACACACACACACACACACACACACACACACATACACTTCGTGCATGCAGCTAGGGGACTGCAGCAGTGCAACCAGGGGGACAGCAGGAGGAGCTCTCTTTGCAGTCCCTGCTTCTAACCCCCACTAACTAAAGATGAACTCATGCCAGTTCCATTCTTTGCTCTGCAAAGAAAACACACACACACACACACACACACACACACACACACACACACACACGGCAGAAGAGAGTAGCCTCCAGATTTCCCCTCTGAGCACACTGTCTTTCTAGCCTCTTCGTTCAAGCAACCCGGATATTCCAAGCAGAGTAACGGGGAGTAACGCGCCACAACAATGCAACCTCCCTAGCAGCTCCCCTCGCAGCTCCCACCCCCGCCCCCTTTCGCGGCGTGCCAAGAGTTTGGAGCGCGCGCACGCACACCGAGCACGGTGCAGGGAGGATATCCCTCCGCCTCCCTCCCCCTTTCTCCGCTAAGTGGCTCGACAACGATTTGGGAAATGAAGGGAGGAGGGAACTACTTTCCTGAAACTTGCTATGCTGCACATGACTTCGAGTTGCAGTGATTCGCCCGGAGGCCGCGGCTTTTAGTCCTACCCACACACCCTCACAGCCTGGGCACCCCGCTCGGCAGCCCCACCCCGCGCCCGCTCTGGCCTCCGGGGAAAGCGGGCGGCCGGGAGAAGTCGCGAGGGACTACTTCGCCTCCTTCTCTCGCGGGCGCCCCCGGTTCGGGCAGCGGCTGCGGCGGCGGAAGGAGCGGGCGGCGTGAGCGCTTCCGCCGCCCCCCTCGCGGCTCCCCTCTCTCGGGCGTGAGGAGCTGGCCCGCTGAGCTGCTGGTGGGCACTGGCTGGCGGGGAACCTGCAGCCGCTCTTGTCCTCTCCCGCCGCTTCTCGGGATCCTGCCCCCCGGACCCGGGCCCGCCCGCTCTTCTCCGGCCGGGTGGGAACGATCGGTTTGCCTGCCCCTCGCCTCACACGCTCCCCGCCGCCCCCTCCACCCCCCTGAGGAGGAGTCCCGGCTGGAGCGTGTCTGGAGGAATCCGCCGCCGCGGGGCCCCTAGCCCTGCTCTGCCGGCGCCTGAGGACCGACCCAGACGCCGCCGGGGGTTGAGGGGCAGCCGGCGGCGAGGCGGGAGATGGTGGGGTGGGCTCCGGCAGGACCGCGCCGCCGCTGCCCGGAGCCTGGGCTCGGCACCCCCCCGCCGGCCCCCACCGAGCGGAGCTCTGCTTCCTCCTCGCCGCATCCCTGAGGGAAGCGCCGCCTCTGCTCCCGGGTTCTCCGCCCGCCGACTCCTTCCTGGCCGGACCCCGCTGCGCTCCACCCCAGTGGCTGGAGGAGCAGCTCTCCAGTCAGCCTTTGCAGCCCCTCTCTTTTTCCCTTTCCACCGGGCCTCCTCGGATCCCTTGGCTGGGCACTGAGGCGGGGGAAGAGGCTGGGGTCGCCACGGCGGAGGTTGCTGCCGCCACCCCCCTGCGGGGGTGGCCGGGGTTCCCGGCTGGGGGGGTACCGTTCTGGGTGAGGCATCCACCATGGTGAGGCCCCTGTGCCGCTGCCCCCGCGCCCCCCCGGCCGCCGCTGCCTCCTGCCCCTCGGTGCTGCTGTTGCTCCCCCGCCTGCTGTTGCTCCTCCATCTCCAGATCGGATCACGGTGAGGGAAAGATGAGCGAGGAGACGGCGACTTCTGACAACGAGTAAGCGCCTCATTGATCTCGATTGCTAATCCCCCTCCCCCTATCCGCCCTCGGCTCTCCCCCAGACCCATCCGAAACTTGGGTGCCGGAAAGCTTGCGACCCTGGAGAGTTCGGTGCATCTTCTGGAGATAGCTGATTTCTTTAGCCATTTTTAGTGGCAGCACCCCTCCCCATCCTCCCACATTTAGCTGCTTTCTTTTGGGGTAGGGGATTAAGTGTTGGGAGAGGATGGCAATTGTACGTCTATGAGAGGGAATAATGTGGATGGATGGAAGTGGAGTAGAAACTACCCCTTTGCCTGTGAGACCCCTGTCCCGTCCTTTTTCACTCACATACCAGTCACCATACCTTCAGTATCCATCCTACTTCCTTTATAGCTGTTTCACTTGGAAACTAATGTGTGGGAGCACCTCCTGCAGCAAACTGCTCTTGAATCTTAATTCGATGAGTCAGTGACTCTTAAATACCGATTAAGCCTTCACCCTCTCCCCCCTCCCCCTTTTAAACTTATGACCTGTAAGATTCTTGTAAAAAATAGGGTTAGGGAAACATTTTTAGAATTTAATAGGATTAAGGACACCTGGAGTGTGGGCGATGTTGAGCTAGAGTTTACCTTTGTGAATATTGGACGTGTCTTCAGGAACGGAGAAGAATTTTGAATGCTAATTTTTACCTTTCAGCTATGTGAAAACACATGATTTACGTTGATGTAACCGAATTTACATTGCTGAATATGTTGGTGATTTCATTAACTTTTAGAGCATTCCGGTTTAAGTTTTAGCTTATTTGGGCTTTCTCCTTGCTTTCCAAACGAAATACTTCGTCTTTTAAATGTTTTGCTTTAACGTGACAGCTGCGTGGAGAAATAATGGTTGGCAACACTTTTCTATTGAGAAGGGATTTAATTCCAAGCAGAATATTAGCATCCGTTTTCTTGTAATTAAGTTCAACTTTTGTTTATCTTCGGAGGGTTGGAAAGAGTTAAGTGAGTTAGGACTTAGTCATTTGGATGCATTCCTTTAAATACAGTGCATTACTAAAGTCAGACCTTTTTGAAATAACTTTTTAAAGTCTGTACCGAGTCCTGTTTAACGTAAAATAGCTAGAGAAAGGCCAAACAACATTTCCTCCTCCCTTACTCCCTCCCCACCCCAAAACACACGCTTCTGCTGAGCGGGTGTAGAAGGAGGTACATTGCTGCAGTGTCAGTGCAGTGTAGAAGCAGAAGTGGCAGCCATGTTCTGTCTCTTTTTGTGAATCGCCCTCATTTGCATAGCACACTCTTCATTCATAAAAAAAATAATTAAACATCCATCACCTTGGACATCTTGAAAGGATTTCCCAAGAAAAAAAATTCGCGGCTTATTTGTCTGTGTGTAGATTTTTGAGTTCAGAAGGTAAGAAGAATGTGAAATTTTAGGTTAAATTTAAAAACATACGCACACACAAACAACTACCCCTGTTCTGAGAATGTTGACACAGTTATGTGGGAAATATCAGTTCGGGGAGGTGCTGGGATCACGTGATCGCCTCCATTCATAAAATACCTGGCTGTCCATTCAGAGTGCAGTACAGTCTCTCCCTGCCTTCTGCAGATTAGACCTACTTTGAGGGAGATCAAGAAGTCTATCTCAGATAATGGTTATTTAGGAGAAGAACTGCTAAAAATGCTGAACCGAATGACGGTAACTTTTATTGGTATCTTTCAAAAAGTTTGGATTAAAAATGTTAAGTTTTCTTTTAGAGATGGGAAAAGACTTCTTACCAGTTTAATTTTTTTCTTAAAGCAGTGAATATCTCCTTGTTTCCTTCTGGTTGCAGCTAATAAAAAAAGCAGATGATGGAATGTGAATTAACACAAGTAAAATATATTTTTTCTAAATGGCCATTTTTTTAAATACTTGCCATAAATAAATTGAGACAACAGGTTTTTTTGTATAGTGATAGTGCGTTCCACTGCTATTACAGTAAATTGAGAAAATACTCCCAGTGATTTAATCCCCAAGATGTTGATA
TTAGGCTCCAGCCCGCAACCCCAGTAGGTTTCTGTGCAAAAATCTTTTGAGATGAATGCATACTTTGTCTTCTAACAATGCATTCGTGACAGCTGTCTATCCAATCGGTCCGCCTCCGTTCAGAGCAGTTCGTGCCACAGAAGCATCTCCTGCGCTATAGTTATGCAACCTCACTCGCAGCGGGAGTTATTTCCTCCGTTCTGGCTGCGCCAGATTCATGTAACACGCCTACCCTGGGCTTCAATGGAAGTCGTTCTCCATTAACAATCACTCCAGCTTTCCGAGATGAATGCCCTGATAGCATACCCCTTGCGCAGTAAGAATCCAGGCAGCGAGGCGAGGTGTTAAAACACACATACATTCTCATATTCTCTCTCTCTCTCTCTCACACACACACACACACACACACACACACACATACACTTCGTGCATGCAGCTAGGGGACTGCAGCAGTGCAACCAGGGGGACAGCAGGAGGAGCTCTCTTTGCAGTCCCTGCTTCTAACCCCCACTAACTAAAGATGAACTCATGCCAGTTCCATTCTTTGCTCTGCAAAGAAAACACACACACACACACACACACACACACACACACACACACACACACGGCAGAAGAGAGTAGCCTCCAGATTTCCCCTCTGAGCACACTGTCTTTCTAGCCTCTTCGTTCAAGCAACCCGGATATTCCAAGCAGAGTAACGGGGAGTAACGCGCCACAACAATGCAACCTCCCTAGCAGCTCCCCTCGCAGCTCCCACCCCCGCCCCCTTTCGCGGCGTGCCAAGAGTTTGGAGCGCGCGCACGCACACCGAGCACGGTGCAGGGAGGATATCCCTCCGCCTCCCTCCCCCTTTCTCCGCTAAGTGGCTCGACAACGATTTGGGAAATGAAGGGAGGAGGGAACTACTTTCCTGAAACTTGCTATGCTGCACATGACTTCGAGTTGCAGTGATTCGCCCGGAGGCCGCGGCTTTTAGTCCTACCCACACACCCTCACAGCCTGGGCACCCCGCTCGGCAGCCCCACCCCGCGCCCGCTCTGGCCTCCGGGGAAAGCGGGCGGCCGGGAGAAGTCGCGAGGGACTACTTCGCCTCCTTCTCTCGCGGGCGCCCCCGGTTCGGGCAGCGGCTGCGGCGGCGGAAGGAGCGGGCGGCGTGAGCGCTTCCGCCGCCCCCCTCGCGGCTCCCCTCTCTCGGGCGTGAGGAGCTGGCCCGCTGAGCTGCTGGTGGGCACTGGCTGGCGGGGAACCTGCAGCCGCTCTTGTCCTCTCCCGCCGCTTCTCGGGATCCTGCCCCCCGGACCCGGGCCCGCCCGCTCTTCTCCGGCCGGGTGGGAACGATCGGTTTGCCTGCCCCTCGCCTCACACGCTCCCCGCCGCCCCCTCCACCCCCCTGAGGAGGAGTCCCGGCTGGAGCGTGTCTGGAGGAATCCGCCGCCGCGGGGCCCCTAGCCCTGCTCTGCCGGCGCCTGAGGACCGACCCAGACGCCGCCGGGGGTTGAGGGGCAGCCGGCGGCGAGGCGGGAGATGGTGGGGTGGGCTCCGGCAGGACCGCGCCGCCGCTGCCCGGAGCCTGGGCTCGGCACCCCCCCGCCGGCCCCCACCGAGCGGAGCTCTGCTTCCTCCTCGCCGCATCCCTGAGGGAAGCGCCGCCTCTGCTCCCGGGTTCTCCGCCCGCCGACTCCTTCCTGGCCGGACCCCGCTGCGCTCCACCCCAGTGGCTGGAGGAGCAGCTCTCCAGTCAGCCTTTGCAGCCCCTCTCTTTTTCCCTTTCCACCGGGCCTCCTCGGATCCCTTGGCTGGGCACTGAGGCGGGGGAAGAGGCTGGGGTCGCCACGGCGGAGGTTGCTGCCGCCACCCCCCTGCGGGGGTGGCCGGGGTTCCCGGCTGGGGGGGTACCGTTCTGGGTGAGGCATCCACCATGGTGAGGCCCCTGTGCCGCTGCCCCCGCGCCCCCCCGGCCGCCGCTGCCTCCTGCCCCTCGGTGCTGCTGTTGCTCCCCCGCCTGCTGTTGCTCCTCCATCTCCAGATCGGATCACGGTGAGGGAAAGGTGAGCGAGGAGACGGCGACTTCTGACAACGAGTAAGCGCCTCATTGATCTCGATTGCTAATCCCCCTCCCCCTATCCGCCCTCGGCTCTCCCCCAGACCCATCCGAAACTTGGGTGCCGGAAAGCTTGCGACCCTGGAGAGTTCGGTGCATCTTCTGGAGATAGCTGATTTCTTTAGCCATTTTTAGTGGCAGCACCCCTCCCCATCCTCCCACATTTAGCTGCTTTCTTTTGGGGTAGGGGATTAAGTGTTGGGAGAGGATGGCAATTGTACGTCTATGAGAGGGAATAATGTGGATGGATGGAAGTGGAGTAGAAACTACCCCTTTGCCTGTGAGACCCCTGTCCCGTCCTTTTTCACTCACATACCAGTCACCATACCTTCAGTATCCATCCTACTTCCTTTATAGCTGTTTCACTTGGAAACTAATGTGTGGGAGCACCTCCTGCAGCAAACTGCTCTTGAATCTTAATTCGATGAGTCAGTGACTCTTAAATACCGATTAAGCCTTCACCCTCTCCCCCCTCCCCCTTTTAAACTTATGACCTGTAAGATTCTTGTAAAAAATAGGGTTAGGGAAACATTTTTAGAATTTAATAGGATTAAGGACACCTGGAGTGTGGGCGATGTTGAGCTAGAGTTTACCTTTGTGAATATTGGACGTGTCTTCAGGAACGGAGAAGAATTTTGAATGCTAATTTTTACCTTTCAGCTATGTGAAAACACATGATTTACGTTGATGTAACCGAATTTACATTGCTGAATATGTTGGTGATTTCATTAACTTTTAGAGCATTCCGGTTTAAGTTTTAGCTTATTTGGGCTTTCTCCTTGCTTTCCAAACGAAATACTTCGTCTTTTAAATGTTTTGCTTTAACGTGACAGCTGCGTGGAGAAATAATGGTTGGCAACACTTTTCTATTGAGAAGGGATTTAATTCCAAGCAGAATATTAGCATCCGTTTTCTTGTAATTAAGTTCAACTTTTGTTTATCTTCGGAGGGTTGGAAAGAGTTAAGTGAGTTAGGACTTAGTCATTTGGATGCATTCCTTTAAATACAGTGCATTACTAAAGTCAGACCTTTTTGAAATAACTTTTTAAAGTCTGTACCGAGTCCTGTTTAACGTAAAATAGCTAGAGAAAGGCCAAACAACATTTCCTCCTCCCTTACTCCCTCCCCACCCCAAAACACACGCTTCTGCTGAGCGGGTGTAGAAGGAGGTACATTGCTGCAGTGTCAGTGCAGTGTAGAAGCAGAAGTGGCAGCCATGTTCTGTCTCTTTTTGTGAATCGCCCTCATTTGCATAGCACACTCTTCATTCATAAAAAAAATAATTAAACATCCATCACCTTGGACATCTTGAAAGGATTTCCCAAGAAAAAAAATTCGCGGCTTATTTGTCTGTGTGTAGATTTTTGAGTTCAGAAGGTAAGAAGAATGTGAAATTTTAGGTTAAATTTAAAAACATACGCACACACAAACAACTACCCCTGTTCTGAGAATGTTGACACAGTTATGTGGGAAATATCAGTTCGGGGAGGTGCTGGGATCACGTGATCGCCTCCATTCATAAAATACCTGGCTGTCCATTCAGAGTGCAGTACAGTCTCTCCCTGCCTTCTGCAGATTAGACCTACTTTGAGGGAGATCAAGAAGTCTATCTCAGATAATGGTTATTTAGGAGAAGAACTGCTAAAAATGCTGAACCGAATGACGGTAACTTTTATTGGTATCTTTCAAAAAGTTTGGATTAAAAATGTTAAGTTTTCTTTTAGAGATGGGAAAAGACTTCTTACCAGTTTAATTTTTTTCTTAAAGCAGTGAATATCTCCTTGTTTCCTTCTGGTTGCAGCTAATAAAAAAAGCAGATGATGGAATGTGAATTAACACAAGTAAAATATATTTTTTCTAAATGGCCATTTTTTTAAATACTTGCCATAAATAAATTGAGACAACAGGTTTTTTTGTATAGTGATAGTGCGTTCCACTGCTATTACAGTAAATTGAGAAAATACTCCCAGTGATTTAATCCCCAAGATGTTGATA
Task1_train_20516
Here’s a variant in SPRED1 (sprouty related EVH1 domain containing 1) located on Chromosome 15. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Legius syndrome
AGGCTCCAGCCCGCAACCCCAGTAGGTTTCTGTGCAAAAATCTTTTGAGATGAATGCATACTTTGTCTTCTAACAATGCATTCGTGACAGCTGTCTATCCAATCGGTCCGCCTCCGTTCAGAGCAGTTCGTGCCACAGAAGCATCTCCTGCGCTATAGTTATGCAACCTCACTCGCAGCGGGAGTTATTTCCTCCGTTCTGGCTGCGCCAGATTCATGTAACACGCCTACCCTGGGCTTCAATGGAAGTCGTTCTCCATTAACAATCACTCCAGCTTTCCGAGATGAATGCCCTGATAGCATACCCCTTGCGCAGTAAGAATCCAGGCAGCGAGGCGAGGTGTTAAAACACACATACATTCTCATATTCTCTCTCTCTCTCTCTCACACACACACACACACACACACACACACACATACACTTCGTGCATGCAGCTAGGGGACTGCAGCAGTGCAACCAGGGGGACAGCAGGAGGAGCTCTCTTTGCAGTCCCTGCTTCTAACCCCCACTAACTAAAGATGAACTCATGCCAGTTCCATTCTTTGCTCTGCAAAGAAAACACACACACACACACACACACACACACACACACACACACACACACGGCAGAAGAGAGTAGCCTCCAGATTTCCCCTCTGAGCACACTGTCTTTCTAGCCTCTTCGTTCAAGCAACCCGGATATTCCAAGCAGAGTAACGGGGAGTAACGCGCCACAACAATGCAACCTCCCTAGCAGCTCCCCTCGCAGCTCCCACCCCCGCCCCCTTTCGCGGCGTGCCAAGAGTTTGGAGCGCGCGCACGCACACCGAGCACGGTGCAGGGAGGATATCCCTCCGCCTCCCTCCCCCTTTCTCCGCTAAGTGGCTCGACAACGATTTGGGAAATGAAGGGAGGAGGGAACTACTTTCCTGAAACTTGCTATGCTGCACATGACTTCGAGTTGCAGTGATTCGCCCGGAGGCCGCGGCTTTTAGTCCTACCCACACACCCTCACAGCCTGGGCACCCCGCTCGGCAGCCCCACCCCGCGCCCGCTCTGGCCTCCGGGGAAAGCGGGCGGCCGGGAGAAGTCGCGAGGGACTACTTCGCCTCCTTCTCTCGCGGGCGCCCCCGGTTCGGGCAGCGGCTGCGGCGGCGGAAGGAGCGGGCGGCGTGAGCGCTTCCGCCGCCCCCCTCGCGGCTCCCCTCTCTCGGGCGTGAGGAGCTGGCCCGCTGAGCTGCTGGTGGGCACTGGCTGGCGGGGAACCTGCAGCCGCTCTTGTCCTCTCCCGCCGCTTCTCGGGATCCTGCCCCCCGGACCCGGGCCCGCCCGCTCTTCTCCGGCCGGGTGGGAACGATCGGTTTGCCTGCCCCTCGCCTCACACGCTCCCCGCCGCCCCCTCCACCCCCCTGAGGAGGAGTCCCGGCTGGAGCGTGTCTGGAGGAATCCGCCGCCGCGGGGCCCCTAGCCCTGCTCTGCCGGCGCCTGAGGACCGACCCAGACGCCGCCGGGGGTTGAGGGGCAGCCGGCGGCGAGGCGGGAGATGGTGGGGTGGGCTCCGGCAGGACCGCGCCGCCGCTGCCCGGAGCCTGGGCTCGGCACCCCCCCGCCGGCCCCCACCGAGCGGAGCTCTGCTTCCTCCTCGCCGCATCCCTGAGGGAAGCGCCGCCTCTGCTCCCGGGTTCTCCGCCCGCCGACTCCTTCCTGGCCGGACCCCGCTGCGCTCCACCCCAGTGGCTGGAGGAGCAGCTCTCCAGTCAGCCTTTGCAGCCCCTCTCTTTTTCCCTTTCCACCGGGCCTCCTCGGATCCCTTGGCTGGGCACTGAGGCGGGGGAAGAGGCTGGGGTCGCCACGGCGGAGGTTGCTGCCGCCACCCCCCTGCGGGGGTGGCCGGGGTTCCCGGCTGGGGGGGTACCGTTCTGGGTGAGGCATCCACCATGGTGAGGCCCCTGTGCCGCTGCCCCCGCGCCCCCCCGGCCGCCGCTGCCTCCTGCCCCTCGGTGCTGCTGTTGCTCCCCCGCCTGCTGTTGCTCCTCCATCTCCAGATCGGATCACGGTGAGGGAAAGATGAGCGAGGAGACGGCGACTTCTGACAACGAGTAAGCGCCTCATTGATCTCGATTGCTAATCCCCCTCCCCCTATCCGCCCTCGGCTCTCCCCCAGACCCATCCGAAACTTGGGTGCCGGAAAGCTTGCGACCCTGGAGAGTTCGGTGCATCTTCTGGAGATAGCTGATTTCTTTAGCCATTTTTAGTGGCAGCACCCCTCCCCATCCTCCCACATTTAGCTGCTTTCTTTTGGGGTAGGGGATTAAGTGTTGGGAGAGGATGGCAATTGTACGTCTATGAGAGGGAATAATGTGGATGGATGGAAGTGGAGTAGAAACTACCCCTTTGCCTGTGAGACCCCTGTCCCGTCCTTTTTCACTCACATACCAGTCACCATACCTTCAGTATCCATCCTACTTCCTTTATAGCTGTTTCACTTGGAAACTAATGTGTGGGAGCACCTCCTGCAGCAAACTGCTCTTGAATCTTAATTCGATGAGTCAGTGACTCTTAAATACCGATTAAGCCTTCACCCTCTCCCCCCTCCCCCTTTTAAACTTATGACCTGTAAGATTCTTGTAAAAAATAGGGTTAGGGAAACATTTTTAGAATTTAATAGGATTAAGGACACCTGGAGTGTGGGCGATGTTGAGCTAGAGTTTACCTTTGTGAATATTGGACGTGTCTTCAGGAACGGAGAAGAATTTTGAATGCTAATTTTTACCTTTCAGCTATGTGAAAACACATGATTTACGTTGATGTAACCGAATTTACATTGCTGAATATGTTGGTGATTTCATTAACTTTTAGAGCATTCCGGTTTAAGTTTTAGCTTATTTGGGCTTTCTCCTTGCTTTCCAAACGAAATACTTCGTCTTTTAAATGTTTTGCTTTAACGTGACAGCTGCGTGGAGAAATAATGGTTGGCAACACTTTTCTATTGAGAAGGGATTTAATTCCAAGCAGAATATTAGCATCCGTTTTCTTGTAATTAAGTTCAACTTTTGTTTATCTTCGGAGGGTTGGAAAGAGTTAAGTGAGTTAGGACTTAGTCATTTGGATGCATTCCTTTAAATACAGTGCATTACTAAAGTCAGACCTTTTTGAAATAACTTTTTAAAGTCTGTACCGAGTCCTGTTTAACGTAAAATAGCTAGAGAAAGGCCAAACAACATTTCCTCCTCCCTTACTCCCTCCCCACCCCAAAACACACGCTTCTGCTGAGCGGGTGTAGAAGGAGGTACATTGCTGCAGTGTCAGTGCAGTGTAGAAGCAGAAGTGGCAGCCATGTTCTGTCTCTTTTTGTGAATCGCCCTCATTTGCATAGCACACTCTTCATTCATAAAAAAAATAATTAAACATCCATCACCTTGGACATCTTGAAAGGATTTCCCAAGAAAAAAAATTCGCGGCTTATTTGTCTGTGTGTAGATTTTTGAGTTCAGAAGGTAAGAAGAATGTGAAATTTTAGGTTAAATTTAAAAACATACGCACACACAAACAACTACCCCTGTTCTGAGAATGTTGACACAGTTATGTGGGAAATATCAGTTCGGGGAGGTGCTGGGATCACGTGATCGCCTCCATTCATAAAATACCTGGCTGTCCATTCAGAGTGCAGTACAGTCTCTCCCTGCCTTCTGCAGATTAGACCTACTTTGAGGGAGATCAAGAAGTCTATCTCAGATAATGGTTATTTAGGAGAAGAACTGCTAAAAATGCTGAACCGAATGACGGTAACTTTTATTGGTATCTTTCAAAAAGTTTGGATTAAAAATGTTAAGTTTTCTTTTAGAGATGGGAAAAGACTTCTTACCAGTTTAATTTTTTTCTTAAAGCAGTGAATATCTCCTTGTTTCCTTCTGGTTGCAGCTAATAAAAAAAGCAGATGATGGAATGTGAATTAACACAAGTAAAATATATTTTTTCTAAATGGCCATTTTTTTAAATACTTGCCATAAATAAATTGAGACAACAGGTTTTTTTGTATAGTGATAGTGCGTTCCACTGCTATTACAGTAAATTGAGAAAATACTCCCAGTGATTTAATCCCCAAGATGTTGATATT
AGGCTCCAGCCCGCAACCCCAGTAGGTTTCTGTGCAAAAATCTTTTGAGATGAATGCATACTTTGTCTTCTAACAATGCATTCGTGACAGCTGTCTATCCAATCGGTCCGCCTCCGTTCAGAGCAGTTCGTGCCACAGAAGCATCTCCTGCGCTATAGTTATGCAACCTCACTCGCAGCGGGAGTTATTTCCTCCGTTCTGGCTGCGCCAGATTCATGTAACACGCCTACCCTGGGCTTCAATGGAAGTCGTTCTCCATTAACAATCACTCCAGCTTTCCGAGATGAATGCCCTGATAGCATACCCCTTGCGCAGTAAGAATCCAGGCAGCGAGGCGAGGTGTTAAAACACACATACATTCTCATATTCTCTCTCTCTCTCTCTCACACACACACACACACACACACACACACACATACACTTCGTGCATGCAGCTAGGGGACTGCAGCAGTGCAACCAGGGGGACAGCAGGAGGAGCTCTCTTTGCAGTCCCTGCTTCTAACCCCCACTAACTAAAGATGAACTCATGCCAGTTCCATTCTTTGCTCTGCAAAGAAAACACACACACACACACACACACACACACACACACACACACACACACGGCAGAAGAGAGTAGCCTCCAGATTTCCCCTCTGAGCACACTGTCTTTCTAGCCTCTTCGTTCAAGCAACCCGGATATTCCAAGCAGAGTAACGGGGAGTAACGCGCCACAACAATGCAACCTCCCTAGCAGCTCCCCTCGCAGCTCCCACCCCCGCCCCCTTTCGCGGCGTGCCAAGAGTTTGGAGCGCGCGCACGCACACCGAGCACGGTGCAGGGAGGATATCCCTCCGCCTCCCTCCCCCTTTCTCCGCTAAGTGGCTCGACAACGATTTGGGAAATGAAGGGAGGAGGGAACTACTTTCCTGAAACTTGCTATGCTGCACATGACTTCGAGTTGCAGTGATTCGCCCGGAGGCCGCGGCTTTTAGTCCTACCCACACACCCTCACAGCCTGGGCACCCCGCTCGGCAGCCCCACCCCGCGCCCGCTCTGGCCTCCGGGGAAAGCGGGCGGCCGGGAGAAGTCGCGAGGGACTACTTCGCCTCCTTCTCTCGCGGGCGCCCCCGGTTCGGGCAGCGGCTGCGGCGGCGGAAGGAGCGGGCGGCGTGAGCGCTTCCGCCGCCCCCCTCGCGGCTCCCCTCTCTCGGGCGTGAGGAGCTGGCCCGCTGAGCTGCTGGTGGGCACTGGCTGGCGGGGAACCTGCAGCCGCTCTTGTCCTCTCCCGCCGCTTCTCGGGATCCTGCCCCCCGGACCCGGGCCCGCCCGCTCTTCTCCGGCCGGGTGGGAACGATCGGTTTGCCTGCCCCTCGCCTCACACGCTCCCCGCCGCCCCCTCCACCCCCCTGAGGAGGAGTCCCGGCTGGAGCGTGTCTGGAGGAATCCGCCGCCGCGGGGCCCCTAGCCCTGCTCTGCCGGCGCCTGAGGACCGACCCAGACGCCGCCGGGGGTTGAGGGGCAGCCGGCGGCGAGGCGGGAGATGGTGGGGTGGGCTCCGGCAGGACCGCGCCGCCGCTGCCCGGAGCCTGGGCTCGGCACCCCCCCGCCGGCCCCCACCGAGCGGAGCTCTGCTTCCTCCTCGCCGCATCCCTGAGGGAAGCGCCGCCTCTGCTCCCGGGTTCTCCGCCCGCCGACTCCTTCCTGGCCGGACCCCGCTGCGCTCCACCCCAGTGGCTGGAGGAGCAGCTCTCCAGTCAGCCTTTGCAGCCCCTCTCTTTTTCCCTTTCCACCGGGCCTCCTCGGATCCCTTGGCTGGGCACTGAGGCGGGGGAAGAGGCTGGGGTCGCCACGGCGGAGGTTGCTGCCGCCACCCCCCTGCGGGGGTGGCCGGGGTTCCCGGCTGGGGGGGTACCGTTCTGGGTGAGGCATCCACCATGGTGAGGCCCCTGTGCCGCTGCCCCCGCGCCCCCCCGGCCGCCGCTGCCTCCTGCCCCTCGGTGCTGCTGTTGCTCCCCCGCCTGCTGTTGCTCCTCCATCTCCAGATCGGATCACGGTGAGGGAAAGATAAGCGAGGAGACGGCGACTTCTGACAACGAGTAAGCGCCTCATTGATCTCGATTGCTAATCCCCCTCCCCCTATCCGCCCTCGGCTCTCCCCCAGACCCATCCGAAACTTGGGTGCCGGAAAGCTTGCGACCCTGGAGAGTTCGGTGCATCTTCTGGAGATAGCTGATTTCTTTAGCCATTTTTAGTGGCAGCACCCCTCCCCATCCTCCCACATTTAGCTGCTTTCTTTTGGGGTAGGGGATTAAGTGTTGGGAGAGGATGGCAATTGTACGTCTATGAGAGGGAATAATGTGGATGGATGGAAGTGGAGTAGAAACTACCCCTTTGCCTGTGAGACCCCTGTCCCGTCCTTTTTCACTCACATACCAGTCACCATACCTTCAGTATCCATCCTACTTCCTTTATAGCTGTTTCACTTGGAAACTAATGTGTGGGAGCACCTCCTGCAGCAAACTGCTCTTGAATCTTAATTCGATGAGTCAGTGACTCTTAAATACCGATTAAGCCTTCACCCTCTCCCCCCTCCCCCTTTTAAACTTATGACCTGTAAGATTCTTGTAAAAAATAGGGTTAGGGAAACATTTTTAGAATTTAATAGGATTAAGGACACCTGGAGTGTGGGCGATGTTGAGCTAGAGTTTACCTTTGTGAATATTGGACGTGTCTTCAGGAACGGAGAAGAATTTTGAATGCTAATTTTTACCTTTCAGCTATGTGAAAACACATGATTTACGTTGATGTAACCGAATTTACATTGCTGAATATGTTGGTGATTTCATTAACTTTTAGAGCATTCCGGTTTAAGTTTTAGCTTATTTGGGCTTTCTCCTTGCTTTCCAAACGAAATACTTCGTCTTTTAAATGTTTTGCTTTAACGTGACAGCTGCGTGGAGAAATAATGGTTGGCAACACTTTTCTATTGAGAAGGGATTTAATTCCAAGCAGAATATTAGCATCCGTTTTCTTGTAATTAAGTTCAACTTTTGTTTATCTTCGGAGGGTTGGAAAGAGTTAAGTGAGTTAGGACTTAGTCATTTGGATGCATTCCTTTAAATACAGTGCATTACTAAAGTCAGACCTTTTTGAAATAACTTTTTAAAGTCTGTACCGAGTCCTGTTTAACGTAAAATAGCTAGAGAAAGGCCAAACAACATTTCCTCCTCCCTTACTCCCTCCCCACCCCAAAACACACGCTTCTGCTGAGCGGGTGTAGAAGGAGGTACATTGCTGCAGTGTCAGTGCAGTGTAGAAGCAGAAGTGGCAGCCATGTTCTGTCTCTTTTTGTGAATCGCCCTCATTTGCATAGCACACTCTTCATTCATAAAAAAAATAATTAAACATCCATCACCTTGGACATCTTGAAAGGATTTCCCAAGAAAAAAAATTCGCGGCTTATTTGTCTGTGTGTAGATTTTTGAGTTCAGAAGGTAAGAAGAATGTGAAATTTTAGGTTAAATTTAAAAACATACGCACACACAAACAACTACCCCTGTTCTGAGAATGTTGACACAGTTATGTGGGAAATATCAGTTCGGGGAGGTGCTGGGATCACGTGATCGCCTCCATTCATAAAATACCTGGCTGTCCATTCAGAGTGCAGTACAGTCTCTCCCTGCCTTCTGCAGATTAGACCTACTTTGAGGGAGATCAAGAAGTCTATCTCAGATAATGGTTATTTAGGAGAAGAACTGCTAAAAATGCTGAACCGAATGACGGTAACTTTTATTGGTATCTTTCAAAAAGTTTGGATTAAAAATGTTAAGTTTTCTTTTAGAGATGGGAAAAGACTTCTTACCAGTTTAATTTTTTTCTTAAAGCAGTGAATATCTCCTTGTTTCCTTCTGGTTGCAGCTAATAAAAAAAGCAGATGATGGAATGTGAATTAACACAAGTAAAATATATTTTTTCTAAATGGCCATTTTTTTAAATACTTGCCATAAATAAATTGAGACAACAGGTTTTTTTGTATAGTGATAGTGCGTTCCACTGCTATTACAGTAAATTGAGAAAATACTCCCAGTGATTTAATCCCCAAGATGTTGATATT
Task1_train_20517
Consider this mutation in SPRED1 (sprouty related EVH1 domain containing 1) on Chromosome 15. Is this a benign change or a disease-causing variant?
Pathogenic; Legius syndrome
GCTCCAGCCCATCTCAGGAGAATTTAATATCTACATCAACCCAACCTTCATGCACCCGCACTTCCTCTGACTGTTTCTCTGAGTTGAAGATTGGCAAGAATTGGGTCCAGATAAGAATCAGAGCCTCTGAATAACTAAATAATAAAAAGCTTCCACAAAAGAGTAAATTATGAAGCCAAACCCTTTCAGAGTTTCTATATAAAGAATTATTTTGACCCCAATAATAGATAATTATGGTTGAACATGAAAATTCAATTATTTCCCAGATCCTGATTTTGAATTACCAGGATGGTAGTGTCTTCGGTTTTCAATGCTTTGTTGTCATAATGATAATAAAAAGTAATACTCATATAGTGCTTGTTATGTGTCAGGCATGGTTTACATTTATTATAAGTGAGTGCTGTTATTTCACACGTAAGTTTGAGGCACAGAGGTTTAGTAACTTTCTCAAAGCCATACAGATAGTAAGTTTCTAAGCCAAGATCCAACTTGTGGAAATTTGACTCTAGAATTCTCACTCTTAACCACAACCCAGTGCAACTTTAAAAGTATATTCTCTAAAAAATACTTATGTCCAGAATATATTTTAAAAAACACTTCTAAAAATCATAATAAAGACAATATAATAAAAAATGGTCACAGACTTAAAAACAAGATAAACAAATGGCCAAAAAGCACATGAAAAGATGCTCAACATCATGAGTCATTATGGAAATAGAAATTTAAAACGCTGTGGGATACCACTATATACTCAATACAATGAGTAAAGTTAAGACTGAAAACACCAAGTATTGGCAAGGATGTGGTGCATCTGAAACTGTCATACATTATTGATGGGAATGTGTAACAGTACAACCACTTTGGAAGATAATGTCTTGTATAGTTAAACATGTACCTATCCTGTGACCCGTTAATTCCACTCCTAGGTAATTATTTGAGAAATGAAAAAATGTCTACAAAAAAGACATGTACAAGAATGTTTATAACAGCTTTATTCATAATTGCCAACAACTAGAAAAATCCAAATGCCTGTCCATGTAAGAAAGAATAAATTATGATAGATTTATTCAATTAGAGGACTACTTAGTTAAAAAAAATTAACTTCTGGTACACAAAACAACATGAGAGAAAGAAGTCAGACAAAAAGAGTACAAATGGTAATTCTGTTTGATTCCATTTATTTGAAGGCCCCAAACAGGCAAAATCTCTGTGTTCGGCATAAGGATTTTTGAAGTGATGAAAATGGCCTGTATTTTGATTATCATGTTGATTATACATGTGTCTTATTCTCTTTGGACTACTATAGAAAAATATAAACTGGTTAGCTAATAACAGAAATTTATTTCTTACAGTTTCTACAGACCAATTTGCTTGTTAAGTAATCTAAGCATAACACTTTTCTTTATATGATTTGTGTAAGTGATTCAGATTCCCAGTTGGTAGAATAAATTAAAAATGTAGCTAAACTAAGCATGTTTGTTTCAGCATTTGATTTATAATATTCTGGAACTGTTAGGGACTTCTAGATGCTGCAGTTTAATGTGCTGAAATACAGCAGTTTGTCCTGGTTATAATATTGTAGCAAATGGACATATATAGACAAGTTTTATGGTACCCTGTGTAGTTTGACAGTATTTGCCTCTGGGATCCTTCACAACTTGTTCCGTGGCAATCAGATGTGCTGGAACTACTGAAATGATGAATTGAGGTAGTAGTTTTGTAGTCTTTTATTACAAGAGTAGTCTTTAAAATAAAGGACAACCTTAAAGTCTGTTTTTGGTTTTTGACCTCTTTCAAGTAGGCTACTTTCTGTAGATTTTCATGGAAGTAGTAAACACCTTAGTCACCACATGTTAACTAATGTGTTCTTTGGTTTCTCAAACAAGACTGATGGCTTGGCTGTTTTTTGTTTATGGAAAAGCTAATTCCTGATCTTTGCATCTATTTTAGTAATAGTTATGCACGAGTGCGAGCTGTGGTGATGACCCGAGATGACTCAAGTGGTGGATGGTTACCACTTGGAGGGAGTGGACTAAGCAGCGTCACTGTCTTCAAAGTCCCTCATCAGGAAGAGAATGGCTGTGCTGACTTTTTTATCCGTGGAGAGCGACTCAGGGACAAAATGGTAATGAATAATGTATCTAATACTATAATTTTAGATAATGAATTATCTGTTTAAAGTTATGATTAGTATACTGTTGTGAGTTTTTTTCACCTGTGAATCAGTAATTATGTTTCTGGAGCTGTTTCTGTGTTAAAGGCAGTGAAATACAACATTTTTTTTTCAAACTGAGACTGACATTGATACACATTTGTTGGGGGATGGGGTTGCTGCTTTTCCATTTACGCTTAATGCAGGAGTTAATAAATAGTCCCCCTAGTTATTCAACCGGTAACATCCTGCCTTCCCTTCTCTCAGCTATTCCCTAGACCAGAGATTGGCAAACTAATCCACAGGCCAAATGCAAGCCCACCAATTGTTTTTATATTGTCTGTGAGCTAATAATGGTTTTTATAGTTTTACATGGTTGGAAAAAATTAAAAATAATAATTTTGTGTAACATAAGAATTATATGAAATTCCCATTTCAGTATCCACAAATTAAGTTTTATTCGAACATAGCCAAGGTGATTCCCTTATTAATTCCCTTATTTTCTAGTCTCATAAGACTATCTGGTGGCCAGCCTAATTTTTAACACTATTGTCTTCCATGCAGATGTGTGGTTTCTTACCTGTATACATTTTAAAATTTCAGTTTAACCTTTGATAATGTTATTTGCTCTTTTTTAATTAGTATGGAAAGCTCCTTCACTTTCTTTGTTTCATTTGTGGGCCAAAAACAACTGATTACATCCGAAAAGCTGAGTAATGTTAGTGTCATTTCTGTATCAAGAAAAAGAAGAGCATACACTTAGACGCAAAATAAAAATAAAGTCCCAAAATAGAGCCTTGAAAATAACGAGAATTCCCTTTAAATATATATTTGTGGATCTGTTTATTTAGCATCTTTGTTATTTCTTATGTTTTGAGCTCCAAATAATTCTTCCATGCATGAACAGTTTGAATATGACTTACTTTCAGTTTGGGGGCTTGGTTTCTTCATATTTTTTTTACATCTGAATCATTGTAGTAATTCAGAAAGTTGCTTAACTTTCACTGCCCCAATTTCTTCCCCACTTAAAGGGAGAGTTATCCTAAATCATCTCGAAAGCCTTCCTACACTAATGTTTTATGAGTTTATGATTCACCCATGCTACACATTGTATAATGTGTCTCAGCCAAAATATGTTTAAGTAGAGAACCCCGATTGAAGTCAAAAGTGAAATATGATAAATATGTCATCTTTAAAAAGTTTAAATTTTTAAAGGTGGTCTGGCCTTGGATAAAATGGGATCTGCCATATACTAATGCTTTTTTAAGCCTGGAGACATCTAAGAAGGCGCCTATGATGGTATAATGCTTCTGGTCTGAGCTAATGGTAACTGGGGAATATTGTTGGAGAAATTGTCTATTTTAGAAACCGAGTAAAATGGTGAAAATCTAAGGCATTTTTTTCTAGATAAACTTTTTCCTAAGAATACAAAGGTAGTAGAAAGTAAAATGTGGATTAAGAGAGAAAAATGCTTGCTCGAAAAATTATAAGAACAAGGAAAGGATGATCTAGATGTGAAATAGAAAAAACTCAGTGAAACAGAATATTGGATATAGTAGAGATGGACAGTTTAGGATAATAAGGGACCAAATCTGCATAACTAATTATGAGTCTGCACAGATTGATGGATTGGGTGATTGTTCAGAGTGTGGCTTTAACATAAATAAAGCTAGTAAAAATAAACCTGAGATTCAGAAAGAACAGAAACTTTTATTCCCTATGACAGCTTAAAAATCAAGAGCACTTACCCTAGTCCTAGGGTATAGAATATTGATAGACTAATAAGAAAATAGATTATTTTGCTAGAAGTAACAGGAATCAGAACACCTGATGTTTCACGTAGCCATTTTTCTTTGAGGAAGCTTGTTACTTGTGAAACGGGGATAAGAAACATCTCTCAGTATTGCCATAAAGGAGAGCTTTCAGTCAGAAATTTGCCATATT
GCTCCAGCCCATCTCAGGAGAATTTAATATCTACATCAACCCAACCTTCATGCACCCGCACTTCCTCTGACTGTTTCTCTGAGTTGAAGATTGGCAAGAATTGGGTCCAGATAAGAATCAGAGCCTCTGAATAACTAAATAATAAAAAGCTTCCACAAAAGAGTAAATTATGAAGCCAAACCCTTTCAGAGTTTCTATATAAAGAATTATTTTGACCCCAATAATAGATAATTATGGTTGAACATGAAAATTCAATTATTTCCCAGATCCTGATTTTGAATTACCAGGATGGTAGTGTCTTCGGTTTTCAATGCTTTGTTGTCATAATGATAATAAAAAGTAATACTCATATAGTGCTTGTTATGTGTCAGGCATGGTTTACATTTATTATAAGTGAGTGCTGTTATTTCACACGTAAGTTTGAGGCACAGAGGTTTAGTAACTTTCTCAAAGCCATACAGATAGTAAGTTTCTAAGCCAAGATCCAACTTGTGGAAATTTGACTCTAGAATTCTCACTCTTAACCACAACCCAGTGCAACTTTAAAAGTATATTCTCTAAAAAATACTTATGTCCAGAATATATTTTAAAAAACACTTCTAAAAATCATAATAAAGACAATATAATAAAAAATGGTCACAGACTTAAAAACAAGATAAACAAATGGCCAAAAAGCACATGAAAAGATGCTCAACATCATGAGTCATTATGGAAATAGAAATTTAAAACGCTGTGGGATACCACTATATACTCAATACAATGAGTAAAGTTAAGACTGAAAACACCAAGTATTGGCAAGGATGTGGTGCATCTGAAACTGTCATACATTATTGATGGGAATGTGTAACAGTACAACCACTTTGGAAGATAATGTCTTGTATAGTTAAACATGTACCTATCCTGTGACCCGTTAATTCCACTCCTAGGTAATTATTTGAGAAATGAAAAAATGTCTACAAAAAAGACATGTACAAGAATGTTTATAACAGCTTTATTCATAATTGCCAACAACTAGAAAAATCCAAATGCCTGTCCATGTAAGAAAGAATAAATTATGATAGATTTATTCAATTAGAGGACTACTTAGTTAAAAAAAATTAACTTCTGGTACACAAAACAACATGAGAGAAAGAAGTCAGACAAAAAGAGTACAAATGGTAATTCTGTTTGATTCCATTTATTTGAAGGCCCCAAACAGGCAAAATCTCTGTGTTCGGCATAAGGATTTTTGAAGTGATGAAAATGGCCTGTATTTTGATTATCATGTTGATTATACATGTGTCTTATTCTCTTTGGACTACTATAGAAAAATATAAACTGGTTAGCTAATAACAGAAATTTATTTCTTACAGTTTCTACAGACCAATTTGCTTGTTAAGTAATCTAAGCATAACACTTTTCTTTATATGATTTGTGTAAGTGATTCAGATTCCCAGTTGGTAGAATAAATTAAAAATGTAGCTAAACTAAGCATGTTTGTTTCAGCATTTGATTTATAATATTCTGGAACTGTTAGGGACTTCTAGATGCTGCAGTTTAATGTGCTGAAATACAGCAGTTTGTCCTGGTTATAATATTGTAGCAAATGGACATATATAGACAAGTTTTATGGTACCCTGTGTAGTTTGACAGTATTTGCCTCTGGGATCCTTCACAACTTGTTCCGTGGCAATCAGATGTGCTGGAACTACTGAAATGATGAATTGAGGTAGTAGTTTTGTAGTCTTTTATTACAAGAGTAGTCTTTAAAATAAAGGACAACCTTAAAGTCTGTTTTTGGTTTTTGACCTCTTTCAAGTAGGCTACTTTCTGTAGATTTTCATGGAAGTAGTAAACACCTTAGTCACCACATGTTAACTAATGTGTTCTTTGGTTTCTCAAACAAGACTGATGGCTTGGCTGTTTTTTGTTTATGGAAAAGCTAATTCCTGATCTTTGCATCTATTTTAGTAATAGTTATGCACGAGTGCGAGCTGTGGTGATGACCCGAGATGACTCAAGTGGTGGATGGTTACCACTTGGAGGGAGTGGACTAAGCAGCGTCACTGACTTCAAAGTCCCTCATCAGGAAGAGAATGGCTGTGCTGACTTTTTTATCCGTGGAGAGCGACTCAGGGACAAAATGGTAATGAATAATGTATCTAATACTATAATTTTAGATAATGAATTATCTGTTTAAAGTTATGATTAGTATACTGTTGTGAGTTTTTTTCACCTGTGAATCAGTAATTATGTTTCTGGAGCTGTTTCTGTGTTAAAGGCAGTGAAATACAACATTTTTTTTTCAAACTGAGACTGACATTGATACACATTTGTTGGGGGATGGGGTTGCTGCTTTTCCATTTACGCTTAATGCAGGAGTTAATAAATAGTCCCCCTAGTTATTCAACCGGTAACATCCTGCCTTCCCTTCTCTCAGCTATTCCCTAGACCAGAGATTGGCAAACTAATCCACAGGCCAAATGCAAGCCCACCAATTGTTTTTATATTGTCTGTGAGCTAATAATGGTTTTTATAGTTTTACATGGTTGGAAAAAATTAAAAATAATAATTTTGTGTAACATAAGAATTATATGAAATTCCCATTTCAGTATCCACAAATTAAGTTTTATTCGAACATAGCCAAGGTGATTCCCTTATTAATTCCCTTATTTTCTAGTCTCATAAGACTATCTGGTGGCCAGCCTAATTTTTAACACTATTGTCTTCCATGCAGATGTGTGGTTTCTTACCTGTATACATTTTAAAATTTCAGTTTAACCTTTGATAATGTTATTTGCTCTTTTTTAATTAGTATGGAAAGCTCCTTCACTTTCTTTGTTTCATTTGTGGGCCAAAAACAACTGATTACATCCGAAAAGCTGAGTAATGTTAGTGTCATTTCTGTATCAAGAAAAAGAAGAGCATACACTTAGACGCAAAATAAAAATAAAGTCCCAAAATAGAGCCTTGAAAATAACGAGAATTCCCTTTAAATATATATTTGTGGATCTGTTTATTTAGCATCTTTGTTATTTCTTATGTTTTGAGCTCCAAATAATTCTTCCATGCATGAACAGTTTGAATATGACTTACTTTCAGTTTGGGGGCTTGGTTTCTTCATATTTTTTTTACATCTGAATCATTGTAGTAATTCAGAAAGTTGCTTAACTTTCACTGCCCCAATTTCTTCCCCACTTAAAGGGAGAGTTATCCTAAATCATCTCGAAAGCCTTCCTACACTAATGTTTTATGAGTTTATGATTCACCCATGCTACACATTGTATAATGTGTCTCAGCCAAAATATGTTTAAGTAGAGAACCCCGATTGAAGTCAAAAGTGAAATATGATAAATATGTCATCTTTAAAAAGTTTAAATTTTTAAAGGTGGTCTGGCCTTGGATAAAATGGGATCTGCCATATACTAATGCTTTTTTAAGCCTGGAGACATCTAAGAAGGCGCCTATGATGGTATAATGCTTCTGGTCTGAGCTAATGGTAACTGGGGAATATTGTTGGAGAAATTGTCTATTTTAGAAACCGAGTAAAATGGTGAAAATCTAAGGCATTTTTTTCTAGATAAACTTTTTCCTAAGAATACAAAGGTAGTAGAAAGTAAAATGTGGATTAAGAGAGAAAAATGCTTGCTCGAAAAATTATAAGAACAAGGAAAGGATGATCTAGATGTGAAATAGAAAAAACTCAGTGAAACAGAATATTGGATATAGTAGAGATGGACAGTTTAGGATAATAAGGGACCAAATCTGCATAACTAATTATGAGTCTGCACAGATTGATGGATTGGGTGATTGTTCAGAGTGTGGCTTTAACATAAATAAAGCTAGTAAAAATAAACCTGAGATTCAGAAAGAACAGAAACTTTTATTCCCTATGACAGCTTAAAAATCAAGAGCACTTACCCTAGTCCTAGGGTATAGAATATTGATAGACTAATAAGAAAATAGATTATTTTGCTAGAAGTAACAGGAATCAGAACACCTGATGTTTCACGTAGCCATTTTTCTTTGAGGAAGCTTGTTACTTGTGAAACGGGGATAAGAAACATCTCTCAGTATTGCCATAAAGGAGAGCTTTCAGTCAGAAATTTGCCATATT
Task1_train_20518
A variant on Chromosome 15 in gene RASGRP1 (RAS guanyl releasing protein 1) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Immunodeficiency 64
AGAAGTCACAACCCAAATAAAATAGCTGCAAATTAACTGAGCCCCATTTTACTGTGCTATATGGCTGCTGATGGGTGGAAAACCTATGAGTAGGACCAAAATCGCTCCTTAAGAGAGATATATAAAGCAAACATCTTACTGGTTCTAAAAGAAAGTAGCCACAACTCATTGCATATATTTTGAATATATTCATTCAATTAATATATTCCAGTGAATACATTTAATACCCCCCTCCCACTATAAATATAACTTTAAATCCACTTGTTTTTTTAAAACAATTATCCCAGTAACATCCTCACTACCCCTAAAGTTTTGTAATAAACAGAAGATATCAAATGCCTTTCAATTCACAGCACAGATAAATTTCCCTCCAACCTCATGTTGGAGAGAAAACTTGTGTTTGGTAAAACTGTTTAGCACTGTACAGGAAAAACAAAAAAACCCTGAGATAGTCTTCTATGAAGGGACCAAGCCACTCAAAAGAAATGAAGGTTGAAACTGATGTTTTCACTTGCAAATAGAACACTGTTCAACCCCTGGGGACACTGGCTGGGATTCCTCGTTCTGCACTGATTTTTCACTTCTGCCTCCACTGATGTGAGCATTGGCATCAAGCAGACATCCTGCAGGCCTGACCAAGCAGCCTGCCAGTTTGACCCCTGCAGAGCTCAGATTTCCTGTGTGATAAATGGCTTTTTTCAGTGGCTCAGCTCTGACTGCTGTCCTTCCCTGTGACGGGGAGGCACTGCCAAATGGGAACTCCTGAGGCAGAGCTTTTCAATTTGGGTCTGGGGTACTGAGGGGTGCAGAGAATGGAGAGTTAATGCTTGGAGAAGTTATTTCCAAATGGAAGCTGGGAGCTTCCTGGCTGAGTGACCAAACAGCTGCGTGAAAACAGAAGGGCTGTCAATATTATGAATGAAAATGTAAAATAACCTTTGTAACCTGATTTGCAGGTCTCCTTCCAGACACAACTGAGCTCAACAAATTGGTGCTGAGTGACTGAGAGAGGCATGTAGTCCTAGCCCCAGCTTTGACTGTAATCAGCTGTGTCGACCTTGTTCAAGTCAGCCCTCTGGGCCTCCATCCCCTCACCAGGAGAATACTGGTCATTTTAATAAATGGACCCAGCAACTAGGTGGTCACTATTTTTAGCACGGAGGTGAAGACTGTATCTGTTGGTAGGGGTAGGGGCTAAGTGGAATAAGGGTTTCATTTCTCAGGAAAGCACATTAGCCAGTGAGGGTCTGTTGGCATCTGACATGTTGACAAGTTCTCTTGCATAGAACTAATATTCTTTGGGATCACATATGGATTGCAGTGAGGAAAGGATGAACCTGTACTCTTTCTGTACCTGATGATCAACTGAAATCTCTCTCCCTTTGACTCTGCTTAGTTGCCCCAGTTGAAAGGTTTTGGGTCAGCACAGCTTATCTCTAGAATCACAGTGACTTCTGGGCCAGGACCACTTCAAGGATTTAGGTATGTTCTGGGCTAGGGCAGTAGAATCTATTTTGGGATTTCCCAGAGCCATTCAAAGCTTACCCCAGAATGAATTCAAACTCTGAGAGGACATATCCTCTCCCCGCCCCCGCACCCCCCCCCCTTTTTTTTTTTGAGGAAGATTTTAAAAAGAGTTGTTGAAGCCTAATGATTATCAGGGGTATGAGGATTATCAGGGGTATGAGGGTAGAATGAGAGAGACAGAGAGAGAGAGAGAGAGAGAGAGTGTGTGTGTGTGTGTGTGATGTGTGCCCACAGTATGGTAACTTGAGTGAGTGGTGGGATGGTATGGGGCGGGGGCATGGAAGAAGAGAGATGGGAGAAGCACAGGAGTCACAATCAAAGGAATTCAGATGGTACTGATTTTTTCAGACTCTATGATGTCTGGCAGGAAAGCCTGCCACGACTTGAGGGGGCCTCTAAGGTTATGAAGCGGATGGGCTGTTGAATTATCATCTTATTTTCAGAAATATCCCAGGGAAGATTTTTCTCCTGCCCCTTGCATACATACCGATATCCTCCGGAAAGACTTGAACTCAAGGTAGGTGAGGTGCTCGGATAGCTCTTCTGGTTCCAGATGGTCAAAGAGCAGGGAGACTTTCCGTTTCTTGCTGGTATTTGATTTTATCCTTTGAGTAAGTTTCCTGGACCAGTCACGGGCATTGCTTTTGTGGGTAAATGTGAAAGGGAGAAGACAGGGAAAAGGAATAAATCGCTTTTTGCAAGTAAATCCATTAACATTTCTCACAAGAATATACAAAACACCATTAGCTAACTTTCCTTGTGAATGCCAAAACAGTGCATTCACAGAGTTTCTCCAAATCAGTTTTTTTCCATGGCAGCCTCCAGGAGGTCTTGCTGGTTTTCAGTGAGCCTTTTAAGTGTGCAGTTGGGTACAGGATAAATGAGTTTACTTTAAGGCAGTGGGAAGGAAGGAGTCTCAGGTATCGGTCAGTTTCCTTGCCTTTGGTCCTGGCTCCTTTGTGTATCATCTGGTATGTCTGCTCCCTCCATTCTGCTTGTGTGTTCCTTCATTCTTGTGTGAATGATAGGGACTCTCTATCTGGTTGGAAATCCCAAGGCAGTGAAACAGTTTTCATGCCAGAAAGAGAGCTCAAAGAACCACAGCAAGATGTCATAAAGGGAGGGAATCACGCGTAGAAACATATGGTCACTCTTGGCAGAGTTGTGTCATTTTCCTCAAATGTCCTCAGCTACTGAAATGACCAAGGAAGCCTAGCTGACCCTAGAGTGCGCCCTGCCCCCATTATTTTCTTGTAATCAACCCATGCATTTCTTATTCAGTTTCCTTCACTAAACAAGCAAAGGGAAGCGGCCCCATTTTGAAAGACAGCAGGTTGCCTGTCTTCCAAACTGGTATTCCTGGGAACCTTGTCTCTTGATAAAAGGGTTCTGTGGTCAATGAGCTTGGGAAGTGCTATAAATTCTGTAGCCTCTTTGGCCAGTGAGCATATTACACACTCTGAAAAGCACTGCAAAAGGAAAGTTTAACTCATTATTCCTCAGTTATATCTGGCCAAGTAATATCCCACAGACTAATAATTCCTACAGAATATAATGTGGAAAATTTTGGTCAAGAAAAGTCAGCTAGGAAATACTGGGACAAGGAGAGCTGGGGTTGAGAATTGCCCTGGGCTCTAATTTCATCTTTAAAATGAAGAAACTATTACTTTGAATAATCTCTTATCTTTCAAGTTGTGTAATTTTAAGCAGAGAAGTACAGAGAATCCAAACTGATAAACAGACTTATTTGGGGCTCTGGAATGTAATCTTGAAATCATTTCTACGTGGCTACAGTGCATCATGGACAGGACCTCAGAGGCTAGCTGCTGCTCTGTCACTAGCTTAACTAGCTGGACCCTAGATGAGTCACATTCTTGCTGAGCCTCAATTTCCCAGTCAGAAAAATCAGGATGTTGGATGAAATGATCTCTAGAATATATATCAGTTCTAGAATTCTATTTCTTAGGGATTTGTACTATTTCAAAATAAAGCAGCCACACTGTGAAAACCCTGGCATACAAAGCATACATTCCCCTCCCCCTAATTAGGAAAGGCACTCATTTTCCCAGAATGGGTCAGTCTTATAAATAAGAATTCCAAGGAATAATTTAAAACATTCCTGGAATCCCATCCAGCTCTGGAAGTCTAAGTGTCTTTCATAGACATCCATATATGTTATAAGCCTTCTCCTGAATACATTTTTTAGTCCTGTCCCATTTACAAGTTCAGGTGTGCCTCCTGGCATTAAGCGTGGGTTCAGTCATTTGCACTTTCAGTTTTTCATTATCTGGATTAATTTTAGTCAATATCTTGCTACCTGATTTCTTTTTGACTGGGACTTACTTTTTCTGCTCCTGGATATGTCACCTACTGCTTTATCACCATGAGGCCTCTCTGCTTTTCTGTTAAATGCCAAGCCTTCACTTTGGTGAGGCAGTTTGAACCTGTGTATTTGAGGGGCTTCTCAGAGTGGAGAAAGAGAGCAGCAGTCACCGCTGGGGGTCAGAAGCCCAACAAGCAACTGGGATTATATTACAGGAGGGAGGTGGTTTCGAAAGATGAGTCAAGA
AGAAGTCACAACCCAAATAAAATAGCTGCAAATTAACTGAGCCCCATTTTACTGTGCTATATGGCTGCTGATGGGTGGAAAACCTATGAGTAGGACCAAAATCGCTCCTTAAGAGAGATATATAAAGCAAACATCTTACTGGTTCTAAAAGAAAGTAGCCACAACTCATTGCATATATTTTGAATATATTCATTCAATTAATATATTCCAGTGAATACATTTAATACCCCCCTCCCACTATAAATATAACTTTAAATCCACTTGTTTTTTTAAAACAATTATCCCAGTAACATCCTCACTACCCCTAAAGTTTTGTAATAAACAGAAGATATCAAATGCCTTTCAATTCACAGCACAGATAAATTTCCCTCCAACCTCATGTTGGAGAGAAAACTTGTGTTTGGTAAAACTGTTTAGCACTGTACAGGAAAAACAAAAAAACCCTGAGATAGTCTTCTATGAAGGGACCAAGCCACTCAAAAGAAATGAAGGTTGAAACTGATGTTTTCACTTGCAAATAGAACACTGTTCAACCCCTGGGGACACTGGCTGGGATTCCTCGTTCTGCACTGATTTTTCACTTCTGCCTCCACTGATGTGAGCATTGGCATCAAGCAGACATCCTGCAGGCCTGACCAAGCAGCCTGCCAGTTTGACCCCTGCAGAGCTCAGATTTCCTGTGTGATAAATGGCTTTTTTCAGTGGCTCAGCTCTGACTGCTGTCCTTCCCTGTGACGGGGAGGCACTGCCAAATGGGAACTCCTGAGGCAGAGCTTTTCAATTTGGGTCTGGGGTACTGAGGGGTGCAGAGAATGGAGAGTTAATGCTTGGAGAAGTTATTTCCAAATGGAAGCTGGGAGCTTCCTGGCTGAGTGACCAAACAGCTGCGTGAAAACAGAAGGGCTGTCAATATTATGAATGAAAATGTAAAATAACCTTTGTAACCTGATTTGCAGGTCTCCTTCCAGACACAACTGAGCTCAACAAATTGGTGCTGAGTGACTGAGAGAGGCATGTAGTCCTAGCCCCAGCTTTGACTGTAATCAGCTGTGTCGACCTTGTTCAAGTCAGCCCTCTGGGCCTCCATCCCCTCACCAGGAGAATACTGGTCATTTTAATAAATGGACCCAGCAACTAGGTGGTCACTATTTTTAGCACGGAGGTGAAGACTGTATCTGTTGGTAGGGGTAGGGGCTAAGTGGAATAAGGGTTTCATTTCTCAGGAAAGCACATTAGCCAGTGAGGGTCTGTTGGCATCTGACATGTTGACAAGTTCTCTTGCATAGAACTAATATTCTTTGGGATCACATATGGATTGCAGTGAGGAAAGGATGAACCTGTACTCTTTCTGTACCTGATGATCAACTGAAATCTCTCTCCCTTTGACTCTGCTTAGTTGCCCCAGTTGAAAGGTTTTGGGTCAGCACAGCTTATCTCTAGAATCACAGTGACTTCTGGGCCAGGACCACTTCAAGGATTTAGGTATGTTCTGGGCTAGGGCAGTAGAATCTATTTTGGGATTTCCCAGAGCCATTCAAAGCTTACCCCAGAATGAATTCAAACTCTGAGAGGACATATCCTCTCCCCGCCCCCGCACCCCCCCCCCTTTTTTTTTTTGAGGAAGATTTTAAAAAGAGTTGTTGAAGCCTAATGATTATCAGGGGTATGAGGATTATCAGGGGTATGAGGGTAGAATGAGAGAGACAGAGAGAGAGAGAGAGAGAGAGAGTGTGTGTGTGTGTGTGTGATGTGTGCCCACAGTATGGTAACTTGAGTGAGTGGTGGGATGGTATGGGGCGGGGGCATGGAAGAAGAGAGATGGGAGAAGCACAGGAGTCACAATCAAAGGAATTCAGATGGTACTGATTTTTTCAGACTCTATGATGTCTGGCAGGAAAGCCTGCCACGACTTGAGGGGGCCTCTAAGGTTATGAAGCGGATGGGCTGTTGAATTATCATCTTATTTTCAGAAATATCCCAGGGAAGATTTTTCTCCTGCCCCTTGCATACATACCGATATCCTCCGGAAAGACTTGAACTCAAGGTAGATGAGGTGCTCGGATAGCTCTTCTGGTTCCAGATGGTCAAAGAGCAGGGAGACTTTCCGTTTCTTGCTGGTATTTGATTTTATCCTTTGAGTAAGTTTCCTGGACCAGTCACGGGCATTGCTTTTGTGGGTAAATGTGAAAGGGAGAAGACAGGGAAAAGGAATAAATCGCTTTTTGCAAGTAAATCCATTAACATTTCTCACAAGAATATACAAAACACCATTAGCTAACTTTCCTTGTGAATGCCAAAACAGTGCATTCACAGAGTTTCTCCAAATCAGTTTTTTTCCATGGCAGCCTCCAGGAGGTCTTGCTGGTTTTCAGTGAGCCTTTTAAGTGTGCAGTTGGGTACAGGATAAATGAGTTTACTTTAAGGCAGTGGGAAGGAAGGAGTCTCAGGTATCGGTCAGTTTCCTTGCCTTTGGTCCTGGCTCCTTTGTGTATCATCTGGTATGTCTGCTCCCTCCATTCTGCTTGTGTGTTCCTTCATTCTTGTGTGAATGATAGGGACTCTCTATCTGGTTGGAAATCCCAAGGCAGTGAAACAGTTTTCATGCCAGAAAGAGAGCTCAAAGAACCACAGCAAGATGTCATAAAGGGAGGGAATCACGCGTAGAAACATATGGTCACTCTTGGCAGAGTTGTGTCATTTTCCTCAAATGTCCTCAGCTACTGAAATGACCAAGGAAGCCTAGCTGACCCTAGAGTGCGCCCTGCCCCCATTATTTTCTTGTAATCAACCCATGCATTTCTTATTCAGTTTCCTTCACTAAACAAGCAAAGGGAAGCGGCCCCATTTTGAAAGACAGCAGGTTGCCTGTCTTCCAAACTGGTATTCCTGGGAACCTTGTCTCTTGATAAAAGGGTTCTGTGGTCAATGAGCTTGGGAAGTGCTATAAATTCTGTAGCCTCTTTGGCCAGTGAGCATATTACACACTCTGAAAAGCACTGCAAAAGGAAAGTTTAACTCATTATTCCTCAGTTATATCTGGCCAAGTAATATCCCACAGACTAATAATTCCTACAGAATATAATGTGGAAAATTTTGGTCAAGAAAAGTCAGCTAGGAAATACTGGGACAAGGAGAGCTGGGGTTGAGAATTGCCCTGGGCTCTAATTTCATCTTTAAAATGAAGAAACTATTACTTTGAATAATCTCTTATCTTTCAAGTTGTGTAATTTTAAGCAGAGAAGTACAGAGAATCCAAACTGATAAACAGACTTATTTGGGGCTCTGGAATGTAATCTTGAAATCATTTCTACGTGGCTACAGTGCATCATGGACAGGACCTCAGAGGCTAGCTGCTGCTCTGTCACTAGCTTAACTAGCTGGACCCTAGATGAGTCACATTCTTGCTGAGCCTCAATTTCCCAGTCAGAAAAATCAGGATGTTGGATGAAATGATCTCTAGAATATATATCAGTTCTAGAATTCTATTTCTTAGGGATTTGTACTATTTCAAAATAAAGCAGCCACACTGTGAAAACCCTGGCATACAAAGCATACATTCCCCTCCCCCTAATTAGGAAAGGCACTCATTTTCCCAGAATGGGTCAGTCTTATAAATAAGAATTCCAAGGAATAATTTAAAACATTCCTGGAATCCCATCCAGCTCTGGAAGTCTAAGTGTCTTTCATAGACATCCATATATGTTATAAGCCTTCTCCTGAATACATTTTTTAGTCCTGTCCCATTTACAAGTTCAGGTGTGCCTCCTGGCATTAAGCGTGGGTTCAGTCATTTGCACTTTCAGTTTTTCATTATCTGGATTAATTTTAGTCAATATCTTGCTACCTGATTTCTTTTTGACTGGGACTTACTTTTTCTGCTCCTGGATATGTCACCTACTGCTTTATCACCATGAGGCCTCTCTGCTTTTCTGTTAAATGCCAAGCCTTCACTTTGGTGAGGCAGTTTGAACCTGTGTATTTGAGGGGCTTCTCAGAGTGGAGAAAGAGAGCAGCAGTCACCGCTGGGGGTCAGAAGCCCAACAAGCAACTGGGATTATATTACAGGAGGGAGGTGGTTTCGAAAGATGAGTCAAGA
Task1_train_20519
A variant affecting Chromosome 15, within the gene EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Familial pulmonary capillary hemangiomatosis
AGTCTAGGAGTTCGAGGCTGCCATGAGTGATGATCGCAACACTGCTTTCCAGCTTGGGTGACAGAGCAAAACCTTATCTCAAAAAAAAAAATTAAAATTAAAAAAAAAGGCCAGCTTAAATCAGTTACAGTTTAACTACTTAGACTTTAACTTAGACTTTAGCTTGCATTGAAATCATTTGGAGCTCTTGTTAAAGCACAGATCACTGTCCAAACCTCCAGAGATGCTGATTTACTAGGTCAGGGGTATAGTAGAATTTGTATTTCTAACATTTTTTAGGGGATACTGATGCTACTGGCCAGGGACCCCACTTTGAGAAGCCCTGGGTTAAAGGTATGGCTTGTTTTTCTTCATTAAAAAACAAAACAAGAATTGTCTATTACACCATTAAACAGTAAGTTAATGGGTTCAAGGAATGAAGATTAAAAGAAAGTATATGAGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACAGGCAGATTGTTTGAGCTCAGGAGTTGGAGACCAGCCTGGGCAGTGTGGTGAAACCCTATCTCTACAAAAAATATAAAAATTAGCCAGGCCTGGTGGTGCCTGCCTGTAGTCCCAGCTACTGAGATGGGAGGATTGCTTGAGCCCGGGAGGCAGAAGTTGGAATGAGCTGAGATCACACCACTGCACTGCAGCCTGGGCGATACGGCAAGACCCTATTTCAAAAAAAAAAAAAAAGCATAAACCAATTTTTAAAAAAAGTATGCAATAGAATATGGGACTTTAAAAAAGCCTTCCCTAAATGTTTCCAACTTGCTTCATCCTGTAATGAGCAGGCTTCATCTAAAGCTCGTCATACTGAGCCACTCTGCTGCACCAACTCTCTGATTTGCTTTGTCTTTCGAAAGCTTTATTTATAACCGGTTCCTGCAAAGGCTTAGTTTGGCATGACAAGGCATTAAACTGTTCATCGAGGTGAAAATTTATAGCCTACTTGTGCTACCTTAGACTTTTAAAAAATTGTTCCATGAGGGTAAGTCTTCTCATCTAGAGATGCCTTTTTTTGATTCGCCTCTTGTACCCAGCCTGTCGCATAGCATGTAAATCCTGCAGGAATGTTTATTAATTTAAATTCACCTATGAGAGTACATTCTGGTCTTTGAGTAACATGAATTCTATAATGTGTATCTTTAAAAAATAAACCCATAGTTAATGCCTTGGATTAACTAGTTTAGCACTGATTGTTTGTGATGCTAAGATTCTTCCTTCCCTCTCACCGAGATGTGTGTGCTTGGATGACAAGGAAAGATGGAGTCCCCAGCAGTTGTTGAAACACAGCTTTATAAATCCCCAGCCAAAAATGCCTCTAGTGGAACAAAGTCCTGAAGGTGAGTCTGTTACCTTTCTTTATTTGGTAACCTGTTTGACATTAAATTATTTTGAAAGTATACATAAACCAAAAACTGGAAGGGGCTGCATGTGTTATTTTATGTCTTTTATTCTGAACTAAATCCATTAGTTTGATGTGTGCCATGTGCATGGGACTGTTTTGCCACCCTGATTTTTCTAGTCTCTATTGATGGAATGAATGTCCATTGCTGTAGTCTCTTGTAGTGTTTAGTCACCCATAGTGCCATGTAACTAGATTTTTCCTGCTGCACCTGAGATTAAGGAACCTCGGTAGAGATTGGGATGGATCATGAGACCTGAGTTTTGGTTCTAGCTCTATAGTTAAGTCACTTATTCTATATAATCCCCCACCTGTAAACTTGGGCTAATTATATATTTCTGCCTACTTTAAGGAGGGCAAGGTGAGGAAAAGTTTTAAAAGGCCACTCAGGTAAGAGGTAATTTTTCAAACTACTGGTTGGAGCTCTTCTTCCAGGGCTTCCATCATTGTTGGCTATGTAGCTCTTCCTAAATTTCCAATGCCTCATGTGCCTCTTACTCCCTGTTTTATCTCAGATTCTGAAGGACAAGATTATGTTGAGACTGTTATTCCTAGCAACCGGCTACCCAGTGCTGCCTTCTTTAGTGAGACACAGAGACAGTTTTCCCGATACTTCATTGAGTTTGAAGAATTACAACTTCTTGGTAAAGGAGCTTTTGGAGCTGTCATCAAGGTGTGGTACAGAGTCATTCCCAGTCCCCTTTAGAGCTCCTTCTCTGTTCCATTTCCACAAAGACTCATGGACTTTACTTTTATTTTGGGAGTGGGGAGGGAAGTGAATATGGCTGTTGGATACTATGCTCATCCTCACCTTCCTGGAGTTAAAGGTTTTATTTAAGTTACGCTGGACACAGTTGAGAATTGTCCCACTCCTCTTTCCTTGCTTCATGTGGAGCATTAACATGAAACACACATGGTTATAACAGCACTTCAAGTGGAATCAAGACCTCCACAGAAAGAACATTTTTGTGTGCTTTGGTTCAGAAAGAACATTGTTCTTTTTTTCTCCTGTTTGCTGTTAGAGTTGCTGTAGATAAAAAGGTTCTAAGGTTAGAAGAGAGATGGACTTCAAACTGGGAGATGGCCCCAGCAGGTCTCGATGGCTTTTATTTTCCAGCTATTATTGGGACAGGAAAGTAGCGATGTATTATTAAGGTACACTGTTGTTGGGTCTTCCTTTCTTCGTTCTAGTCTATTTGGGTGACTTTTATTATTATCTGCCCCTTGTAGAAAGAGGTTTCAGCTGTTTTTATATAATAGAAGTATTTCTTTGTAAATTAGGAGACCCAGATTATTGTATTAAGTCCATATACAGTACATGTCATCTTTCACATATGAAGGTAACCCACCATCAACTGAGTATATTGTCTGTTAAGGATTCTGAGAGTATCATTAGGAAGCATTACTGTTACTGTAGAAAAACTTTTACACTAAAAAAGGAATTAAATTAGTTTTCCTGTGGTAAAAGACAGACAAGCAAGACAGATGTCCTGATCAGAAAGATCATAATTATGTCTAAGAGGAGGGGATGATTGAAGCGTATACTGTCCCTTTAACACAATATCATTTTGATCAAATCCTTTAACTTCATTCTATTTTAAATTCTTGAACGTAGAATAGTAACAAATTTCATCTCTTTACAAGTACTTAATAATGATAGGCAAGCTCATATAACAAAAACATCTGAGTAACTTAAGCCCCCACGGTTTCCAGTAGTTTCTCCCTGTGAGAATCCACAGCCCTCACCTCCTACCTCTGTGCTTCTGTGTCAGAGTAGGGCAGCCTGCCCAGTGATCTGGCATTCATTAGCAGTTGGACCCATTACTGTTTCTGCACCTTTTCACTTCAGTAAATGAATTCCTAGGGGTTTCCAGTATAGCAAGCTTTACTCCCAACCCAGTTCGTATATGATGTGTACTGAGACAGGAGATCGAAAGGCAATGCCAAGATCCCCACCTCCCGCCCTACACTGTCCTCTTCCCTATTAATGTGGCAGTAAAAGAACACAGGGCTATCATTTTTTGGAGCACCTGCCATATTTCAGATTGTGTGCCAGGTGATTTACAAACCTTGTCTTTAAATCTCAGGACATTCTTACGAGATGGGTATGATCCTCATTCCCTAGATGAGGGAACTGAAGCTCAGAGAAGGTTATGTCCTTTGCCTGAGATAAGGGAGATAAAACCAGCATTCAGACCCACCTCTGTTGTACTACAAAGTGTGTGTTCTTGTCACTATTTCCATACAAAAAAAGATAATCTGAAACTCAATTTTGTAGTACTTCCTTCTTATTCCCAGGACTTCACTTAGACTTTTATTAGTTTAATTGAAACTTGTGAGCCAAACAAGAGAATGATATTCTGTTTTGTGTTTTGTAATCAACTAATTTCTCCTGCCACCCATGGCCACATGGCATTTGCTTTTCTAGAGTATATCATCACCTCAGTTGACCTGCACGGATGTGACTACAAGGTTTCAGTGAATAAGACTCTGTAAAAGTTACTTCAGTCACCCCAATTACATAGTGAAACTGCCTGGCATAAGGATGCCTCTATGTAGGATGGGAGGACTTGCCTTTGCAACGTTTTCTTGCTTTCTTATTATTTTACTGTGTTGTTAATTGTATTGTTCTGGTTTCAGTATACATCATCTTAGG
AGTCTAGGAGTTCGAGGCTGCCATGAGTGATGATCGCAACACTGCTTTCCAGCTTGGGTGACAGAGCAAAACCTTATCTCAAAAAAAAAAATTAAAATTAAAAAAAAAGGCCAGCTTAAATCAGTTACAGTTTAACTACTTAGACTTTAACTTAGACTTTAGCTTGCATTGAAATCATTTGGAGCTCTTGTTAAAGCACAGATCACTGTCCAAACCTCCAGAGATGCTGATTTACTAGGTCAGGGGTATAGTAGAATTTGTATTTCTAACATTTTTTAGGGGATACTGATGCTACTGGCCAGGGACCCCACTTTGAGAAGCCCTGGGTTAAAGGTATGGCTTGTTTTTCTTCATTAAAAAACAAAACAAGAATTGTCTATTACACCATTAAACAGTAAGTTAATGGGTTCAAGGAATGAAGATTAAAAGAAAGTATATGAGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACAGGCAGATTGTTTGAGCTCAGGAGTTGGAGACCAGCCTGGGCAGTGTGGTGAAACCCTATCTCTACAAAAAATATAAAAATTAGCCAGGCCTGGTGGTGCCTGCCTGTAGTCCCAGCTACTGAGATGGGAGGATTGCTTGAGCCCGGGAGGCAGAAGTTGGAATGAGCTGAGATCACACCACTGCACTGCAGCCTGGGCGATACGGCAAGACCCTATTTCAAAAAAAAAAAAAAAGCATAAACCAATTTTTAAAAAAAGTATGCAATAGAATATGGGACTTTAAAAAAGCCTTCCCTAAATGTTTCCAACTTGCTTCATCCTGTAATGAGCAGGCTTCATCTAAAGCTCGTCATACTGAGCCACTCTGCTGCACCAACTCTCTGATTTGCTTTGTCTTTCGAAAGCTTTATTTATAACCGGTTCCTGCAAAGGCTTAGTTTGGCATGACAAGGCATTAAACTGTTCATCGAGGTGAAAATTTATAGCCTACTTGTGCTACCTTAGACTTTTAAAAAATTGTTCCATGAGGGTAAGTCTTCTCATCTAGAGATGCCTTTTTTTGATTCGCCTCTTGTACCCAGCCTGTCGCATAGCATGTAAATCCTGCAGGAATGTTTATTAATTTAAATTCACCTATGAGAGTACATTCTGGTCTTTGAGTAACATGAATTCTATAATGTGTATCTTTAAAAAATAAACCCATAGTTAATGCCTTGGATTAACTAGTTTAGCACTGATTGTTTGTGATGCTAAGATTCTTCCTTCCCTCTCACCGAGATGTGTGTGCTTGGATGACAAGGAAAGATGGAGTCCCCAGCAGTTGTTGAAACACAGCTTTATAAATCCCCAGCCAAAAATGCCTCTAGTGGAACAAAGTCCTGAAGGTGAGTCTGTTACCTTTCTTTATTTGGTAACCTGTTTGACATTAAATTATTTTGAAAGTATACATAAACCAAAAACTGGAAGGGGCTGCATGTGTTATTTTATGTCTTTTATTCTGAACTAAATCCATTAGTTTGATGTGTGCCATGTGCATGGGACTGTTTTGCCACCCTGATTTTTCTAGTCTCTATTGATGGAATGAATGTCCATTGCTGTAGTCTCTTGTAGTGTTTAGTCACCCATAGTGCCATGTAACTAGATTTTTCCTGCTGCACCTGAGATTAAGGAACCTCGGTAGAGATTGGGATGGATCATGAGACCTGAGTTTTGGTTCTAGCTCTATAGTTAAGTCACTTATTCTATATAATCCCCCACCTGTAAACTTGGGCTAATTATATATTTCTGCCTACTTTAAGGAGGGCAAGGTGAGGAAAAGTTTTAAAAGGCCACTCAGGTAAGAGGTAATTTTTCAAACTACTGGTTGGAGCTCTTCTTCCAGGGCTTCCATCATTGTTGGCTATGTAGCTCTTCCTAAATTTCCAATGCCTCATGTGCCTCTTACTCCCTGTTTTATCTCAGATTCTGAAGGACAAGATTATGTTGAGACTGTTATTCCTAGCAACCGGCTACCCAGTGCTGCCTTCTTTAGTGAGACACAGAGACAGTTTTCCCAATACTTCATTGAGTTTGAAGAATTACAACTTCTTGGTAAAGGAGCTTTTGGAGCTGTCATCAAGGTGTGGTACAGAGTCATTCCCAGTCCCCTTTAGAGCTCCTTCTCTGTTCCATTTCCACAAAGACTCATGGACTTTACTTTTATTTTGGGAGTGGGGAGGGAAGTGAATATGGCTGTTGGATACTATGCTCATCCTCACCTTCCTGGAGTTAAAGGTTTTATTTAAGTTACGCTGGACACAGTTGAGAATTGTCCCACTCCTCTTTCCTTGCTTCATGTGGAGCATTAACATGAAACACACATGGTTATAACAGCACTTCAAGTGGAATCAAGACCTCCACAGAAAGAACATTTTTGTGTGCTTTGGTTCAGAAAGAACATTGTTCTTTTTTTCTCCTGTTTGCTGTTAGAGTTGCTGTAGATAAAAAGGTTCTAAGGTTAGAAGAGAGATGGACTTCAAACTGGGAGATGGCCCCAGCAGGTCTCGATGGCTTTTATTTTCCAGCTATTATTGGGACAGGAAAGTAGCGATGTATTATTAAGGTACACTGTTGTTGGGTCTTCCTTTCTTCGTTCTAGTCTATTTGGGTGACTTTTATTATTATCTGCCCCTTGTAGAAAGAGGTTTCAGCTGTTTTTATATAATAGAAGTATTTCTTTGTAAATTAGGAGACCCAGATTATTGTATTAAGTCCATATACAGTACATGTCATCTTTCACATATGAAGGTAACCCACCATCAACTGAGTATATTGTCTGTTAAGGATTCTGAGAGTATCATTAGGAAGCATTACTGTTACTGTAGAAAAACTTTTACACTAAAAAAGGAATTAAATTAGTTTTCCTGTGGTAAAAGACAGACAAGCAAGACAGATGTCCTGATCAGAAAGATCATAATTATGTCTAAGAGGAGGGGATGATTGAAGCGTATACTGTCCCTTTAACACAATATCATTTTGATCAAATCCTTTAACTTCATTCTATTTTAAATTCTTGAACGTAGAATAGTAACAAATTTCATCTCTTTACAAGTACTTAATAATGATAGGCAAGCTCATATAACAAAAACATCTGAGTAACTTAAGCCCCCACGGTTTCCAGTAGTTTCTCCCTGTGAGAATCCACAGCCCTCACCTCCTACCTCTGTGCTTCTGTGTCAGAGTAGGGCAGCCTGCCCAGTGATCTGGCATTCATTAGCAGTTGGACCCATTACTGTTTCTGCACCTTTTCACTTCAGTAAATGAATTCCTAGGGGTTTCCAGTATAGCAAGCTTTACTCCCAACCCAGTTCGTATATGATGTGTACTGAGACAGGAGATCGAAAGGCAATGCCAAGATCCCCACCTCCCGCCCTACACTGTCCTCTTCCCTATTAATGTGGCAGTAAAAGAACACAGGGCTATCATTTTTTGGAGCACCTGCCATATTTCAGATTGTGTGCCAGGTGATTTACAAACCTTGTCTTTAAATCTCAGGACATTCTTACGAGATGGGTATGATCCTCATTCCCTAGATGAGGGAACTGAAGCTCAGAGAAGGTTATGTCCTTTGCCTGAGATAAGGGAGATAAAACCAGCATTCAGACCCACCTCTGTTGTACTACAAAGTGTGTGTTCTTGTCACTATTTCCATACAAAAAAAGATAATCTGAAACTCAATTTTGTAGTACTTCCTTCTTATTCCCAGGACTTCACTTAGACTTTTATTAGTTTAATTGAAACTTGTGAGCCAAACAAGAGAATGATATTCTGTTTTGTGTTTTGTAATCAACTAATTTCTCCTGCCACCCATGGCCACATGGCATTTGCTTTTCTAGAGTATATCATCACCTCAGTTGACCTGCACGGATGTGACTACAAGGTTTCAGTGAATAAGACTCTGTAAAAGTTACTTCAGTCACCCCAATTACATAGTGAAACTGCCTGGCATAAGGATGCCTCTATGTAGGATGGGAGGACTTGCCTTTGCAACGTTTTCTTGCTTTCTTATTATTTTACTGTGTTGTTAATTGTATTGTTCTGGTTTCAGTATACATCATCTTAGG
Task1_train_20520
A variant has been detected on Chromosome 15 in EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Familial pulmonary capillary hemangiomatosis
AGCATTACTGTTACTGTAGAAAAACTTTTACACTAAAAAAGGAATTAAATTAGTTTTCCTGTGGTAAAAGACAGACAAGCAAGACAGATGTCCTGATCAGAAAGATCATAATTATGTCTAAGAGGAGGGGATGATTGAAGCGTATACTGTCCCTTTAACACAATATCATTTTGATCAAATCCTTTAACTTCATTCTATTTTAAATTCTTGAACGTAGAATAGTAACAAATTTCATCTCTTTACAAGTACTTAATAATGATAGGCAAGCTCATATAACAAAAACATCTGAGTAACTTAAGCCCCCACGGTTTCCAGTAGTTTCTCCCTGTGAGAATCCACAGCCCTCACCTCCTACCTCTGTGCTTCTGTGTCAGAGTAGGGCAGCCTGCCCAGTGATCTGGCATTCATTAGCAGTTGGACCCATTACTGTTTCTGCACCTTTTCACTTCAGTAAATGAATTCCTAGGGGTTTCCAGTATAGCAAGCTTTACTCCCAACCCAGTTCGTATATGATGTGTACTGAGACAGGAGATCGAAAGGCAATGCCAAGATCCCCACCTCCCGCCCTACACTGTCCTCTTCCCTATTAATGTGGCAGTAAAAGAACACAGGGCTATCATTTTTTGGAGCACCTGCCATATTTCAGATTGTGTGCCAGGTGATTTACAAACCTTGTCTTTAAATCTCAGGACATTCTTACGAGATGGGTATGATCCTCATTCCCTAGATGAGGGAACTGAAGCTCAGAGAAGGTTATGTCCTTTGCCTGAGATAAGGGAGATAAAACCAGCATTCAGACCCACCTCTGTTGTACTACAAAGTGTGTGTTCTTGTCACTATTTCCATACAAAAAAAGATAATCTGAAACTCAATTTTGTAGTACTTCCTTCTTATTCCCAGGACTTCACTTAGACTTTTATTAGTTTAATTGAAACTTGTGAGCCAAACAAGAGAATGATATTCTGTTTTGTGTTTTGTAATCAACTAATTTCTCCTGCCACCCATGGCCACATGGCATTTGCTTTTCTAGAGTATATCATCACCTCAGTTGACCTGCACGGATGTGACTACAAGGTTTCAGTGAATAAGACTCTGTAAAAGTTACTTCAGTCACCCCAATTACATAGTGAAACTGCCTGGCATAAGGATGCCTCTATGTAGGATGGGAGGACTTGCCTTTGCAACGTTTTCTTGCTTTCTTATTATTTTACTGTGTTGTTAATTGTATTGTTCTGGTTTCAGTATACATCATCTTAGGTATATAACAAAATCAATGGGCAGTGATTGTGTTAATAGCAATTGCTGTTATTGACTAAGCTAAGCACCTTTCTCTGTGAGGCCTTGATACAAGTGCTTTACAGTCACCATTTGGGGTAGTGGAAATGGTATAAATGCCATTTTAAAGATAAGAAAATTGAGTCTCAAGGAAATTAAGTAATTTTCCCAAGTTCACACGGCTTTAGAAATCAAGGAATTAACCTTTGTGTTCAGGTCTGTTAATATTTTTGGTGTTTAATTTGTTTTTAGTGACTTTAAGTGTAAAAAAAAATCAGAGAGAAACTAAAATCATCTGAAACTTTACACTGACTTTAGAAAATAATTTTTAATCTTAAAATCAAGACACTTAGAAATTTAGATAGCAGATACATTGGAAAAGCAGGGAGGTAACTGTCAGTAAAATTAATTATTAAAATGGAGATTATGTTTTCCCCAGGGTCTCCCAGCAAGCTAAATATATCTAGAGTCGGGTGGGCTGTTTTCTGAATTTTGTGGCAGTCAAAGCTTTCTTCAGTTTAAGAATTTCAGGCATGTGGTTCTTGACTGTAGCTGTGGGACTCATTTAGAACTTCACGCTTTCCTTGGGAGGGGATGGGGTGCGGTGCAAATGCCTGTTTGTGCAAGGCTCCGAGCGGCTGACCTTCCCCTGGCTGTGCCGCAGGTGCAGAACAAGTTGGACGGCTGCTGCTACGCAGTGAAGCGCATCCCCATCAACCCGGCCAGCCGGCAGTTCCGCAGGATCAAGGGCGAAGTGACACTGCTGTCACGGCTGCACCATGAGAACATTGTGCGCTACTACAACGCCTGGATCGAGCGGCACGAGCGGCCGGCGGGACCGGGGACGCCGCCCCCGGACTCCGGGCCCCTGGCCAAGGATGACCGAGCTGCACGCGGGCAGCCGGCGAGCGACACAGACGGCCTGGACAGCGTAGAGGCCGCCGCGCCGCCACCCATCCTCAGCAGCTCGGTGGAGTGGAGCACTTCGGGCGAGCGCTCGGCCAGTGCCCGTTTCCCCGCCACCGGCCCGGGCTCCAGCGATGACGAGGACGACGACGAGGACGAGCACGGTGGCGTCTTCTCCCAGTCCTTCCTGTAAGCGCACGGCGCGGACCAGCTGCCTCTGATGCGCCCCCTAGTTTCCTTTCTTTATTTTTTTTTCCTTTTTCCTTTCATTTCCTTCCTTCCTTCTTTCCTTCTTTTCTTTCTTTCCTTTTTTGAGATAGGGTCTTGCTCTGTCACCCAGGCTGGAGGTCAGTGGCGCGTCCTTGGCTGCAACATCCGCCTCCCGGGCCAGCGAATGCCCCCCAACATTAATCCCCACCAAGTCCAAGCCAGGGAAAAGGGGATTCATTTAGAAATCCAGACGTGTTGACCATGTTTAAAAACAAAAACAAAAACAAAACAAAACCACCACTTTTAGAGAGTAACCAAATGCAATCTAAAGGAGCGGTCCCCAGCGTTTTTAGGCACCAGGGACTGGTTTCATAGAAGACAATTTTTCCACAGACGGGTGTTAGGGAAATAGTTTCGGGATGAAACTGTTCCACCTTACATCATCAGGCATTAGAGTCTCATAATGACTGCTGAAAAAGCGCACAACCTGGATCCCTCGTGTGCACAGTTCACAATAGTGTTTGCGCTCCTATGAGAATCTAATGCGGCTGCTGATCTGACAGGAGGTGGAGCTCAGGCCTTAATGCTTGCTCACCTCCGGCTGTGCGGCCCTAACAGGCAGTGGACCTGTACCTGTCCATGGCCTGGAGGTTTGGGACCCCTAATCTAAAGGATTTTTTTTCCCGCTATTTTCAAAAGATCTCCAAAATCCAAGCCATGGAAAAAGGAAAATTCAATACCTCATCTTATACATTGAATAGAATTTCTCATAGGACATTCCTTTGGATAAGGGCTTGCAACCCTGTGAAACATTTAAGAACTAATTTGGAGTCTTGATACAGTGCCAACTGCAGCCCCCAAAGGTACCAAACCAATAATTATGATCCTAAATTTTATGCTTCTCAGAATCCACCCTGGATGTTTACTTTCATGATTTTGTTTTATTTTATCCAAGTGGATACAGTTTATGATTACTCTTCACTATTAAATTTTTTGAGGAAACTTAATCTGGCTAATTTTTATTAAATCAAGGGTTCTGTGTTTTGCATAATAGCAAGTACAAATCAGCACAGTGTAGAGTATACATTGATGCCTGTGGGCTCATGGTGTGATGTCTGTAGCCTCTTGTGCTTTCTAGTATTTAAAAATGTCCATGTTTATAATGATAATAGGGATTTCTGTTCCTTTAGTATTTCTGTTTCCCTTTTTCAGGCCTGCTTCAGATTCTGAAAGTGATATTATCTTTGACAATGAAGATGAGAACAGTAAAAGTCAGAATCAGGTATATATATGAATAGAAATTATATCATTTTATTCGTGATATAATTGACGTCTGATGTCATAAACCTTAGGTAAAGTATTAAGGCTTTAATCTGATATTCAGATATAGAAACCATAAATTTTAAAAGATGATTATTCATTTAAAATATATTCTACCTGTGTTTATTTATAGACCTTCTTTATTTATCCACATAGTAAAACATACCTCCTTTTAGAAGAGAGGAGTCAGTTGAGACACTGCATTTTTGTATGTGATGAAAACAGTTTTCTAAGGGTTTGGGAAACTTTATATGGTTGGGGATAAGAATTGAATGCAAATTAATGAACTAGATTTGCATTTATGGAGTTACCTCATCATGGAGTTACCTTGGTCTGTCCCACGTCAATTAATCTTGATTCCTTATTTTCATAGACCATCCTCTAG
AGCATTACTGTTACTGTAGAAAAACTTTTACACTAAAAAAGGAATTAAATTAGTTTTCCTGTGGTAAAAGACAGACAAGCAAGACAGATGTCCTGATCAGAAAGATCATAATTATGTCTAAGAGGAGGGGATGATTGAAGCGTATACTGTCCCTTTAACACAATATCATTTTGATCAAATCCTTTAACTTCATTCTATTTTAAATTCTTGAACGTAGAATAGTAACAAATTTCATCTCTTTACAAGTACTTAATAATGATAGGCAAGCTCATATAACAAAAACATCTGAGTAACTTAAGCCCCCACGGTTTCCAGTAGTTTCTCCCTGTGAGAATCCACAGCCCTCACCTCCTACCTCTGTGCTTCTGTGTCAGAGTAGGGCAGCCTGCCCAGTGATCTGGCATTCATTAGCAGTTGGACCCATTACTGTTTCTGCACCTTTTCACTTCAGTAAATGAATTCCTAGGGGTTTCCAGTATAGCAAGCTTTACTCCCAACCCAGTTCGTATATGATGTGTACTGAGACAGGAGATCGAAAGGCAATGCCAAGATCCCCACCTCCCGCCCTACACTGTCCTCTTCCCTATTAATGTGGCAGTAAAAGAACACAGGGCTATCATTTTTTGGAGCACCTGCCATATTTCAGATTGTGTGCCAGGTGATTTACAAACCTTGTCTTTAAATCTCAGGACATTCTTACGAGATGGGTATGATCCTCATTCCCTAGATGAGGGAACTGAAGCTCAGAGAAGGTTATGTCCTTTGCCTGAGATAAGGGAGATAAAACCAGCATTCAGACCCACCTCTGTTGTACTACAAAGTGTGTGTTCTTGTCACTATTTCCATACAAAAAAAGATAATCTGAAACTCAATTTTGTAGTACTTCCTTCTTATTCCCAGGACTTCACTTAGACTTTTATTAGTTTAATTGAAACTTGTGAGCCAAACAAGAGAATGATATTCTGTTTTGTGTTTTGTAATCAACTAATTTCTCCTGCCACCCATGGCCACATGGCATTTGCTTTTCTAGAGTATATCATCACCTCAGTTGACCTGCACGGATGTGACTACAAGGTTTCAGTGAATAAGACTCTGTAAAAGTTACTTCAGTCACCCCAATTACATAGTGAAACTGCCTGGCATAAGGATGCCTCTATGTAGGATGGGAGGACTTGCCTTTGCAACGTTTTCTTGCTTTCTTATTATTTTACTGTGTTGTTAATTGTATTGTTCTGGTTTCAGTATACATCATCTTAGGTATATAACAAAATCAATGGGCAGTGATTGTGTTAATAGCAATTGCTGTTATTGACTAAGCTAAGCACCTTTCTCTGTGAGGCCTTGATACAAGTGCTTTACAGTCACCATTTGGGGTAGTGGAAATGGTATAAATGCCATTTTAAAGATAAGAAAATTGAGTCTCAAGGAAATTAAGTAATTTTCCCAAGTTCACACGGCTTTAGAAATCAAGGAATTAACCTTTGTGTTCAGGTCTGTTAATATTTTTGGTGTTTAATTTGTTTTTAGTGACTTTAAGTGTAAAAAAAAATCAGAGAGAAACTAAAATCATCTGAAACTTTACACTGACTTTAGAAAATAATTTTTAATCTTAAAATCAAGACACTTAGAAATTTAGATAGCAGATACATTGGAAAAGCAGGGAGGTAACTGTCAGTAAAATTAATTATTAAAATGGAGATTATGTTTTCCCCAGGGTCTCCCAGCAAGCTAAATATATCTAGAGTCGGGTGGGCTGTTTTCTGAATTTTGTGGCAGTCAAAGCTTTCTTCAGTTTAAGAATTTCAGGCATGTGGTTCTTGACTGTAGCTGTGGGACTCATTTAGAACTTCACGCTTTCCTTGGGAGGGGATGGGGTGCGGTGCAAATGCCTGTTTGTGCAAGGCTCCGAGCGGCTGACCTTCCCCTGGCTGTGCCGCAGGTGCAGAACAAGTTGGACGGCTGCTGCTACGCAGTGAAGCGCATCCCCATCAACCCGGCCAGCCGGCAGTTCCGCAGGATCAAGGGCGAAGTGACACTGCTGTCACGGCGGCACCATGAGAACATTGTGCGCTACTACAACGCCTGGATCGAGCGGCACGAGCGGCCGGCGGGACCGGGGACGCCGCCCCCGGACTCCGGGCCCCTGGCCAAGGATGACCGAGCTGCACGCGGGCAGCCGGCGAGCGACACAGACGGCCTGGACAGCGTAGAGGCCGCCGCGCCGCCACCCATCCTCAGCAGCTCGGTGGAGTGGAGCACTTCGGGCGAGCGCTCGGCCAGTGCCCGTTTCCCCGCCACCGGCCCGGGCTCCAGCGATGACGAGGACGACGACGAGGACGAGCACGGTGGCGTCTTCTCCCAGTCCTTCCTGTAAGCGCACGGCGCGGACCAGCTGCCTCTGATGCGCCCCCTAGTTTCCTTTCTTTATTTTTTTTTCCTTTTTCCTTTCATTTCCTTCCTTCCTTCTTTCCTTCTTTTCTTTCTTTCCTTTTTTGAGATAGGGTCTTGCTCTGTCACCCAGGCTGGAGGTCAGTGGCGCGTCCTTGGCTGCAACATCCGCCTCCCGGGCCAGCGAATGCCCCCCAACATTAATCCCCACCAAGTCCAAGCCAGGGAAAAGGGGATTCATTTAGAAATCCAGACGTGTTGACCATGTTTAAAAACAAAAACAAAAACAAAACAAAACCACCACTTTTAGAGAGTAACCAAATGCAATCTAAAGGAGCGGTCCCCAGCGTTTTTAGGCACCAGGGACTGGTTTCATAGAAGACAATTTTTCCACAGACGGGTGTTAGGGAAATAGTTTCGGGATGAAACTGTTCCACCTTACATCATCAGGCATTAGAGTCTCATAATGACTGCTGAAAAAGCGCACAACCTGGATCCCTCGTGTGCACAGTTCACAATAGTGTTTGCGCTCCTATGAGAATCTAATGCGGCTGCTGATCTGACAGGAGGTGGAGCTCAGGCCTTAATGCTTGCTCACCTCCGGCTGTGCGGCCCTAACAGGCAGTGGACCTGTACCTGTCCATGGCCTGGAGGTTTGGGACCCCTAATCTAAAGGATTTTTTTTCCCGCTATTTTCAAAAGATCTCCAAAATCCAAGCCATGGAAAAAGGAAAATTCAATACCTCATCTTATACATTGAATAGAATTTCTCATAGGACATTCCTTTGGATAAGGGCTTGCAACCCTGTGAAACATTTAAGAACTAATTTGGAGTCTTGATACAGTGCCAACTGCAGCCCCCAAAGGTACCAAACCAATAATTATGATCCTAAATTTTATGCTTCTCAGAATCCACCCTGGATGTTTACTTTCATGATTTTGTTTTATTTTATCCAAGTGGATACAGTTTATGATTACTCTTCACTATTAAATTTTTTGAGGAAACTTAATCTGGCTAATTTTTATTAAATCAAGGGTTCTGTGTTTTGCATAATAGCAAGTACAAATCAGCACAGTGTAGAGTATACATTGATGCCTGTGGGCTCATGGTGTGATGTCTGTAGCCTCTTGTGCTTTCTAGTATTTAAAAATGTCCATGTTTATAATGATAATAGGGATTTCTGTTCCTTTAGTATTTCTGTTTCCCTTTTTCAGGCCTGCTTCAGATTCTGAAAGTGATATTATCTTTGACAATGAAGATGAGAACAGTAAAAGTCAGAATCAGGTATATATATGAATAGAAATTATATCATTTTATTCGTGATATAATTGACGTCTGATGTCATAAACCTTAGGTAAAGTATTAAGGCTTTAATCTGATATTCAGATATAGAAACCATAAATTTTAAAAGATGATTATTCATTTAAAATATATTCTACCTGTGTTTATTTATAGACCTTCTTTATTTATCCACATAGTAAAACATACCTCCTTTTAGAAGAGAGGAGTCAGTTGAGACACTGCATTTTTGTATGTGATGAAAACAGTTTTCTAAGGGTTTGGGAAACTTTATATGGTTGGGGATAAGAATTGAATGCAAATTAATGAACTAGATTTGCATTTATGGAGTTACCTCATCATGGAGTTACCTTGGTCTGTCCCACGTCAATTAATCTTGATTCCTTATTTTCATAGACCATCCTCTAG
Task1_train_20521
A variant affecting Chromosome 15, within the gene EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Familial pulmonary capillary hemangiomatosis
AGCTTCACCTTGTCCACAAAAGGATCAAGCCAGTTTCTCACAGATTCTTTTAATGCCTCTAACATAAGTTCTTATGTGAGGTATTGGAAGCCCCTAAAAGTACATGCAAAATGTGTGTATATGCATTCAGGGAAGAGGACCCATACTTTCAGTCACCTACTTGAAGGAGTCCTTGACCTTTCCTCCTCCCTACCCACCCAAGAGATTAAGAAGCAGTGCCTACAAAAATTAGCCGTGCGTGGTGGCATGCACCTGTAATCCCAGCTACCCGGGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGGAGGCAGGCGGAGGTTGCAGAGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACCCCAACTCAAAAAAAAAAAAAAAAAAGAAACAGTGCATTTAGAGACTGATCCCTAGCCCAAACGCCCAGAGCCATAAGCATCAACCAGCTCATATCTAGATGAAGTATAAAGTAGTTCCCAGTGCTGGTTGCACATCTACTTCATCTCAGAAACTCTCTGACAATGCAGATGCCCAGGTCCCGTAGCCCATCTAGTGGCTCAGAATCTCCAGGTGTGAGGCATTTCAGAATCTCATTAAAAGCTCCCAAGCAGTTTCTGAAGTGTAGCCAGGTTGCCAGTTTGGGAAGACTTTAACATTTAATTTCTTTTAAAAAGAAAAAAAATCTGAAGCATATTAGTGAAATGTTAAAATGTGTTAAAGTTGGGTGAGTAGGTAACAGGTATTTGTTATATTCTCTATTATGTTTCTGTTTGCTTAATATATATGATATAATTTAAAAAGATAGAGTAGTGGAGGAAGTCATAGTAAAATTTATGAAAGATCAGTATAGATTTTAGAGACCAAACACAATTTTTACTGGCTGGCAATATTATTATAGAAAGATATTTGCAGGATTATAGGTGACTTTTTTATAGATGTCTTTTTTCATATGTGTTGTTTCTAAATTTTCTATAGTGAAATGGTACTACTTTTATAATACAAAAACAAATGAAAAAGAAAGCTATTGGCAAAATATGTAAATGCCATGTAGCTTTCAACAGGCCTGCCATGAATCACCTTGGTATGTGGGAGGGGCCTGATGCTGTTAGGTGGTCATCGCGCCACAGTATCCCTGAGAGTCAGAGAGAATGTGTTTATTTGATTATCTCCCTCTGAAAGGCAAATATCAATGTGGCCAAGAATTTGGACTTTGAACCCAGGCATCCTTCCCATTGGTTGAAAGGTTAGCTCTTGCTTTCCAAAGCAGGCCATGAAAGATATGTGTCCTCTTCCCTGATGTGTTCAAAGAGGGATGGACTTGTCAAGACTTGTTTTTTGAACCTGGAAATAAGCAGTGTAGTGCCTACTGCAAGCCACAGATTAATATTTTAAAGGATCCCTTTGATAAGGCTTCAATGATGATGTTTTAATCGGTCCTGTTTTAGGGCAACTTCTCAATCCGTACAGCCAAGATGCAGCAGCATGTGTGTGAAACCATCATCCGCATCTTTAAAAGACATGGTATGTACGCCCTTTTTAAAAATGATATTTCTTCTCATAAGACTTTTTTCATCATTAGAAAGTACTGTTAGTGTTCGGGCATATCATATTTTACTTTCAAATTCAGTTATAAATAATTGACATCATATGGAATTTAAGCTTATTTTTGAAACTGATTTGAATATTACAGCCTTACTATTAATACTAAAATGCAATTGGTTTGTGGAGTCAGAAATATGACCAAACTGTCAAACTTAACTCTAGATGAGCTCTCTATTTATAAATTTAGAGAACTCAAGAAAAATTGATATGACTTCAATGGTCCCAGTAGCAATTACTTAACTGTCAGGTTTGTGTTAATTTTAGGTTGCCTTCTAAGGAGAATGTGAACCTGATGATGAGCTATTTTTTCTCATTTGGTGTAGGAGCTGTTCAGTTGTGTACTCCACTACTGCTTCCCCGAAACAGACAAATATATGAGCACAACGAAGCTGCCCTATTCATGGACCACAGCGGGATGCTGGTGATGCTTCCTTTTGACCTGCGGGTGAGGCTGGGAACACACTGCTGACAATCAGAATGCTGTATCTAGTCACAGGGATGGCATCTCTGTTAAAGGATTTTTCCCCCAGGCTTATATTATAAATGTCACCTTTGGGAAATGTATTCTTGAGGAAGTTGTCAGAGTGAGAGTGTTACTGGGGTGGAGGAAATGTTTGGTCCTGAATGCCTCCACCTTCCTAATAGCTCAGGTGTTTATGGCTCTAGGAACTGGAGGAACCCTGCATTGCAGGTGCCACATGTGCACCCCCCAGTGTTGAGTGACCACAGCAGGTTAACCCCACCCACTTAGACAAATAAATGTAGTTTGTTTGTCTTTTTAACTTCCTGGCTAGATCTTCAGTAAACATCCTAACATGTTAATGCCTAGAACAGTTAAATTCTTCTAACAGCAAGTGTCTCTCCTAATTGGGTATGCTGAGTTTTGCCCGTGCCTGCTTTCTTCCGACCCCCAGGGATCCTGTCGACAGCAGCAGTCTTAACTAGTCTTTCACTCACACAGTGTTGGCTACTAACAAGCTATCTGTGGTGCTGTATGATAGAGCAAGGAAAACATGCAATGCATGTGACAGACAAGGTTTAATACCTCTCACATACAGAAAGCACTGACAAGTGGAGACATGAGCAAAGGATATAACCAGGCAGCTCTCAGAAGAGAATATGTGCATGGCTGATAAACTTCTGAAAAGCTGTACTGCCTCACCAATAATAAAGAAGTGCAAAGCTGTCTCAACTTCACCCATCAGACAGGAAACATTTTTAAATTAATGTTATCCAGAGATGACAGGAGTGTAGGAAAGTAGGTATTTTCATATGTTGCTGATGGGAATGTGGACTGCTAAACCTTTAGAAAAGTAATCTAAAAGTTTATAATAAAACTTTAAAAATTTTGTTGCACATTCTTTATCCTTAGAACCAGCAATCCCACTTTGAGCAATTTACTCAAAGAAAGAAAAACACATCAGTGTATGAATGTTAAAAGGATGTTAATTGCCATATTATTGTGGTAGTCAAAAACTGTCTGTCTGTTTATCAGTAGGAAAATGGTTGAATAATTTGTCACCAATATTATGGAATATTAAGGAGCTATTGAAAAGAACATTGAGCTAGGCACAGTGGCTCATGCCTGTAATTCCAGAACTAGGCTAGGTAGGAGGAGTGCTTGAGCCCAGTAGTTCAAGACCAGCCTGGGCAACATAGGAAGACCCCATCTTTACAAAAAATTTAAAAATTAGCCCAGTGTGGTGGCTCGTGCCTGTGGTCTCAGCTACTTGGGAGGTTAAGGCAGGAGGATTGGTTGAGCCCAGGAAGTCAAGGCTTCAGTGAGCCATGATTCTGCCACTGCACTCCAGCCTAGGAAACAGGGCAAGACTCTGTCTCAAAAAGAAAATTTAAAAATTTTTTTTTGTAGAAACGGGCTCTCGCTGTGTTGCCCAGGCTGGTCTCAAACTGCTGGACTCAAGCAGATCCTTCTGCCTCAGCCTCCCAAAATACTGGAATTACAGGCATGAGCCGCCATGCCCAGCCAATCTATATTTTTATATAGATCAAATATGTATTTTTTATATATGTATAAGATGAAAATACAGTCAGCTCTTCGTACATATCCTTGGATTCCACATCCACGTATCCAGCCAACTGTGGATGGAAAATACTCAGAAAAAAAAATTCCAACAAGCAAAATTTGAATTTACCATGTGCTAAACACTGCATTGAATCCACACAAAAGAAGGGATGTATAGGCATAGTAGTAGATATTATAAGTAATCTAAAGATGATTTAAAGTGTACAGGAGGATGCGCATAGGCTATAGGCAAATGCTCTGTCATTTTATATCAGGAACTTAACCATCCACTGATTTTGGTATCCTTGGGGGAGTCCCGGAACCAATTTCTGAGGGACAACTATACATATTTAGATATAGCCATATTTATACTTGATTTGTAGGAATGTGCATGGCACATTGTTAGCTTTTTTTAAAAAGTAAATTTCAAAGGAACTCTATTATCCCATTTTTATT
AGCTTCACCTTGTCCACAAAAGGATCAAGCCAGTTTCTCACAGATTCTTTTAATGCCTCTAACATAAGTTCTTATGTGAGGTATTGGAAGCCCCTAAAAGTACATGCAAAATGTGTGTATATGCATTCAGGGAAGAGGACCCATACTTTCAGTCACCTACTTGAAGGAGTCCTTGACCTTTCCTCCTCCCTACCCACCCAAGAGATTAAGAAGCAGTGCCTACAAAAATTAGCCGTGCGTGGTGGCATGCACCTGTAATCCCAGCTACCCGGGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGGAGGCAGGCGGAGGTTGCAGAGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGACCCCAACTCAAAAAAAAAAAAAAAAAAGAAACAGTGCATTTAGAGACTGATCCCTAGCCCAAACGCCCAGAGCCATAAGCATCAACCAGCTCATATCTAGATGAAGTATAAAGTAGTTCCCAGTGCTGGTTGCACATCTACTTCATCTCAGAAACTCTCTGACAATGCAGATGCCCAGGTCCCGTAGCCCATCTAGTGGCTCAGAATCTCCAGGTGTGAGGCATTTCAGAATCTCATTAAAAGCTCCCAAGCAGTTTCTGAAGTGTAGCCAGGTTGCCAGTTTGGGAAGACTTTAACATTTAATTTCTTTTAAAAAGAAAAAAAATCTGAAGCATATTAGTGAAATGTTAAAATGTGTTAAAGTTGGGTGAGTAGGTAACAGGTATTTGTTATATTCTCTATTATGTTTCTGTTTGCTTAATATATATGATATAATTTAAAAAGATAGAGTAGTGGAGGAAGTCATAGTAAAATTTATGAAAGATCAGTATAGATTTTAGAGACCAAACACAATTTTTACTGGCTGGCAATATTATTATAGAAAGATATTTGCAGGATTATAGGTGACTTTTTTATAGATGTCTTTTTTCATATGTGTTGTTTCTAAATTTTCTATAGTGAAATGGTACTACTTTTATAATACAAAAACAAATGAAAAAGAAAGCTATTGGCAAAATATGTAAATGCCATGTAGCTTTCAACAGGCCTGCCATGAATCACCTTGGTATGTGGGAGGGGCCTGATGCTGTTAGGTGGTCATCGCGCCACAGTATCCCTGAGAGTCAGAGAGAATGTGTTTATTTGATTATCTCCCTCTGAAAGGCAAATATCAATGTGGCCAAGAATTTGGACTTTGAACCCAGGCATCCTTCCCATTGGTTGAAAGGTTAGCTCTTGCTTTCCAAAGCAGGCCATGAAAGATATGTGTCCTCTTCCCTGATGTGTTCAAAGAGGGATGGACTTGTCAAGACTTGTTTTTTGAACCTGGAAATAAGCAGTGTAGTGCCTACTGCAAGCCACAGATTAATATTTTAAAGGATCCCTTTGATAAGGCTTCAATGATGATGTTTTAATCGGTCCTGTTTTAGGGCAACTTCTCAATCCGTACAGCCAAGATGCAGCAGCATGTGTGTGAAACCATCATCCGCATCTTTAAAAGACATGGTATGTACGCCCTTTTTAAAAATGATATTTCTTCTCATAAGACTTTTTTCATCATTAGAAAGTACTGTTAGTGTTCGGGCATATCATATTTTACTTTCAAATTCAGTTATAAATAATTGACATCATATGGAATTTAAGCTTATTTTTGAAACTGATTTGAATATTACAGCCTTACTATTAATACTAAAATGCAATTGGTTTGTGGAGTCAGAAATATGACCAAACTGTCAAACTTAACTCTAGATGAGCTCTCTATTTATAAATTTAGAGAACTCAAGAAAAATTGATATGACTTCAATGGTCCCAGTAGCAATTACTTAACTGTCAGGTTTGTGTTAATTTTAGGTTGCCTTCTAAGGAGAATGTGAACCTGATGATGAGCTATTTTTTCTCATTTGGTGTAGGAGCTGTTCAGTTGTGTACTCCACTACTGCTTCCCCGAAACAGACAAATATATGAGCACAACGAAGCTGCCCTATTCATGGACCACAGCGGGATGCTGGTGATGCTTCTTTTTGACCTGCGGGTGAGGCTGGGAACACACTGCTGACAATCAGAATGCTGTATCTAGTCACAGGGATGGCATCTCTGTTAAAGGATTTTTCCCCCAGGCTTATATTATAAATGTCACCTTTGGGAAATGTATTCTTGAGGAAGTTGTCAGAGTGAGAGTGTTACTGGGGTGGAGGAAATGTTTGGTCCTGAATGCCTCCACCTTCCTAATAGCTCAGGTGTTTATGGCTCTAGGAACTGGAGGAACCCTGCATTGCAGGTGCCACATGTGCACCCCCCAGTGTTGAGTGACCACAGCAGGTTAACCCCACCCACTTAGACAAATAAATGTAGTTTGTTTGTCTTTTTAACTTCCTGGCTAGATCTTCAGTAAACATCCTAACATGTTAATGCCTAGAACAGTTAAATTCTTCTAACAGCAAGTGTCTCTCCTAATTGGGTATGCTGAGTTTTGCCCGTGCCTGCTTTCTTCCGACCCCCAGGGATCCTGTCGACAGCAGCAGTCTTAACTAGTCTTTCACTCACACAGTGTTGGCTACTAACAAGCTATCTGTGGTGCTGTATGATAGAGCAAGGAAAACATGCAATGCATGTGACAGACAAGGTTTAATACCTCTCACATACAGAAAGCACTGACAAGTGGAGACATGAGCAAAGGATATAACCAGGCAGCTCTCAGAAGAGAATATGTGCATGGCTGATAAACTTCTGAAAAGCTGTACTGCCTCACCAATAATAAAGAAGTGCAAAGCTGTCTCAACTTCACCCATCAGACAGGAAACATTTTTAAATTAATGTTATCCAGAGATGACAGGAGTGTAGGAAAGTAGGTATTTTCATATGTTGCTGATGGGAATGTGGACTGCTAAACCTTTAGAAAAGTAATCTAAAAGTTTATAATAAAACTTTAAAAATTTTGTTGCACATTCTTTATCCTTAGAACCAGCAATCCCACTTTGAGCAATTTACTCAAAGAAAGAAAAACACATCAGTGTATGAATGTTAAAAGGATGTTAATTGCCATATTATTGTGGTAGTCAAAAACTGTCTGTCTGTTTATCAGTAGGAAAATGGTTGAATAATTTGTCACCAATATTATGGAATATTAAGGAGCTATTGAAAAGAACATTGAGCTAGGCACAGTGGCTCATGCCTGTAATTCCAGAACTAGGCTAGGTAGGAGGAGTGCTTGAGCCCAGTAGTTCAAGACCAGCCTGGGCAACATAGGAAGACCCCATCTTTACAAAAAATTTAAAAATTAGCCCAGTGTGGTGGCTCGTGCCTGTGGTCTCAGCTACTTGGGAGGTTAAGGCAGGAGGATTGGTTGAGCCCAGGAAGTCAAGGCTTCAGTGAGCCATGATTCTGCCACTGCACTCCAGCCTAGGAAACAGGGCAAGACTCTGTCTCAAAAAGAAAATTTAAAAATTTTTTTTTGTAGAAACGGGCTCTCGCTGTGTTGCCCAGGCTGGTCTCAAACTGCTGGACTCAAGCAGATCCTTCTGCCTCAGCCTCCCAAAATACTGGAATTACAGGCATGAGCCGCCATGCCCAGCCAATCTATATTTTTATATAGATCAAATATGTATTTTTTATATATGTATAAGATGAAAATACAGTCAGCTCTTCGTACATATCCTTGGATTCCACATCCACGTATCCAGCCAACTGTGGATGGAAAATACTCAGAAAAAAAAATTCCAACAAGCAAAATTTGAATTTACCATGTGCTAAACACTGCATTGAATCCACACAAAAGAAGGGATGTATAGGCATAGTAGTAGATATTATAAGTAATCTAAAGATGATTTAAAGTGTACAGGAGGATGCGCATAGGCTATAGGCAAATGCTCTGTCATTTTATATCAGGAACTTAACCATCCACTGATTTTGGTATCCTTGGGGGAGTCCCGGAACCAATTTCTGAGGGACAACTATACATATTTAGATATAGCCATATTTATACTTGATTTGTAGGAATGTGCATGGCACATTGTTAGCTTTTTTTAAAAAGTAAATTTCAAAGGAACTCTATTATCCCATTTTTATT
Task1_train_20522
The following genetic variant occurs in IVD (isovaleryl-CoA dehydrogenase) on Chromosome 15. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Isovaleryl-CoA dehydrogenase deficiency
TCATAGTAGCCTTAAAGTTGGTTGGTATCATTTTCGTTTTAAAGATGATGAAACAGTGACTGAAAAGATCTAAGAAACTTGCCGAAAGTCCCACAGCTATGTAGTGGGATTGCATAGACTCCTGGACTCAGGGTACCAACCTGAGATGAGTTGTTCAAGAGCATTGACTTGGCTGGGTTCCGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGACAGGAGGATCACATGAGCCCAGGAGTTCAAGATCAGCTTGGGCAACATAGTGAGACTGCCCACCCCCACCCCGGCCCCATCTCTAATTAATTAATTAAATTTTAAAAATAACATTGACACAACATGGAGGAGGAAAATAGAGCAAGTGGAGAGGGGATAGAGACTTAATTCCATCAGCTCCCCTCTTTCCCCTCACCACTCTTCCTTTCCCTGTGTCCCGAACCCGTGTTTCTAAGTCCTGACTGCTATTATTCTGGTGTATTAAATACATACTATTTACTATTTAATACATCTTTTGTTGTTGTTTGTTTTCTCAAATTTTTTGTGGAGACAGGGTCTCCCTATGTTGCACAGGATGGTCTTGGACTCCTGGCCTCGAGCGATCTTCCCACCTAAGCTCCCAAAGTCCTAGGATTACAGGCATGAGCAACCATGCCCAGCCTATTTAATACATCTTATTTAATATATAGTATAATACGTAAATATGTACTATTTAATATTTAACACATATTAAATACAAATGGTCCCCAACTTACAATAGTTCAACTTAAGATTTTTCAACTTTATGATGGTGTGAAAGTGATAGACATTGAATAGAAACTGTACAATATTCAATAAATGATATCTAACACTGTCTTATAAAATATGCTTTGTGTTACATGATTGTGCCGTTATAAGCTATTATAAGTGTTCCAAGTACGTTTAAGGTCCACTAGTCTAAGCTATGATGTTTGGTAGGTTAGGTGTTTTTTTGTTTTCTGTTTTGAGACGGAGTGTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCAGCTCACCGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCATGCACCACCACGCCCAGCTAATTTTTGTATTTGTAGTAGAGACAGGATTTCTCCATGTTGGCCAGGCTGGTCTAAAACTCTCCGCCTCAGGTGACTCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCATCATGCCCGGCCTAAGTGTATTTTCAAAGTGCATTTTTGACTTACAATATTTTCCATTTATGATGGGTTTATCGAGAAGTAACCCCACTGTAAATCGAGGCGCATCTCCAATCTAGAAGGCAGCTACTCCTTAATAACCCCTTTCCCATAAAACATGAATCTAAATCTACAAACCTTGTTATATAATAAAGCAAGATGTACTCTGTTATGATCAGTGTGCACGTTAGAGCAAGCACTACTTTTCCGATCTTAATTATTCCAGAGATGCTTGACCAATTTACTGGGTACGTGGGCAGTTTTCTGATTGCTGTTTCCACACTCTGCTTTCCCACAGAGAGATTTCCGCAGTTAGGGGCTGCTATTTCAACGCAGGGAGATAAAAAGAAAAAAACACTTGCTCTTCTACCCCGCTAAAAACACTCATCCTAGGGAGCACGCCAGCATTTGCAGCGTTCGGGGCAGGGCCACTCGGCCTGCGGCCGTTGCACTGGCTGGAAGCTGGCAGGCGATCACGGTTGATTGGCTCGGGTGCGGTCCAAGGGCAGCAACGCCTTCGGCGGGCCGCCTAGGGTGATTGGCTGCTGCAGCCCACCCCCTAGCCGGTTTGGTGGGCGGCGAAGCCTGGATTGGTGGAGCTAAGAGCTGGCTCAGTTTCAGCGCTGGCTCTTCGTGCATGGCAGAGATGGCGACTGCGACTCGGCTGCTGGGGTGGCGTGTGGCGAGCTGGAGGCTGCGGCCGCCGCTTGCCGGCTTCGTTTCCCAGCGGGCCCACTCGCTTTTGCCCGTGGACGATGCAATCAATGGGCTAAGCGAGGAGCAGAGGCAGGTGAGGAGACTGACCCCCTTCCTGGCCCCAAGGCCTCCTTCCTGCCTGGTCCCCAAGGCCTCCTTCCTGCCTGGTCCCCATCGGCCCAGCGCCCACCCAGCCTTGGCTTTTGCCCGTGGGCCGTTGGGAGCGCCAGCGCGGGGGCGGGACGCGGGGCCTCCGACCTCGGGTCCAGTCCTCTGACCTCGGCCTCACGTCTGTGGAGTGAAGATTTGAGACCGTGGGACAGTACTGCTGGAAGTAGAGAGGAGGAGTCGAGGCTGGGAGAGCTCCTGAGAGACTGATGGTGTTTTGGTGGAGGATTGGCCAGGCTACCTACCGCTTGTGGCACAAGGGCCCTCAATCTGTATGTAGTTCACTTACACCTGAACAGGCTGAGGTATGCTTCTCACACCTGGGTGGTCATCGTAATCACCAGGGAGTCTTTTTTGTATAAACAGTTTGGGGGTTTTAAAAAGCCACAGTGAGCTCTCCTGTCGCTCTTCAGCCCATTGGGTCAAAACACAAAAGTTGAACAAGTACTTGAAAGAAGTAGTTGGAGGCCAGGCGCCGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCGAGGTGGGAGGATTGTTTGAGCTCAGGGGTTTGAGATCAGCCTAAGCAACATAGCCAGACCCCCATCTCATAAAAAATAGAAAAGAAGACGAAGTAGTATTTACAAATGGAGCAGAACCAGAGTCCTTCCTGAGGTTTCACTTGGAGGCTGGATGGAGTTGGCGGAGGTATGAGCCTCCCAGCAACTCCGTAGTTTATGTTTATAGCCAGCGAGCGCTCAGAGCTTCCGTGAACCACCTCAAGTGGAAAGGGTTCAATCCCTATTCTCAAGCTTTCCTGGCAAGAGGAGTTTCTTTTCTTTTTTCTTTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGTAATGGCGCGATCTCCGCTCACCACAACGTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAGGTAGCTGGGATTACAGGCATGCACCACCACGCCCGGCTAATTTTGTGTTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCCAACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCCAGCCGCCAAGAGGCGTTTCTAATCTCTTTGGGTAATCAGACCCTTTTAGCCAAAGGTTCGGGGGCTTAAAAGAGCCTGACAACTATTGAGATCTGGCAGCTGCCTGGAATGCAGCTGGAGCACAGAGGGTGGGAGGTGGGAAGGTGCTGGGGAAGCTAGGAGAGTCAGCTGGGGTCAGCTCCTGCAGGGCCTAGTAGGCCTGGGTGAGAAGCTTGTGTTTTATTCTAAGTACAGTGGAAACCAATGGAATGATTTTTATGTAAAGTGTGACGTTTTAAAAATTACCATCAAGCTGTCTAGGCTGAAGACCTTAAGAAAGAGGGGTGAAGATCATCTCTGAGGAGGCATAAACTACTGAGGCCTCTCAGTTTCAGTCTGATGCTGTTTGGGGAAGTTACTTGTGGCCTTTTCTCTTGAATGTGTCTGGGTAGTGGAGATGCTGTCTGCAGTGGCATCTGTTTACCTCTCTCCTATTAGCTTCGTCAGACCATGGCTAAGTTCCTTCAGGAGCACCTGGCCCCCAAGGCCCAGGAGATCGATCGCAGCAATGAGTTCAAGAACCTGCGAGTGAGTTGGGAGGTCCGGGCAGTCGGGGGCAGTCAGGGAGTGGGGCTGAGCTGCACTGCTGCCTGGAAGAGCTCACACAGTTTTCTGGTAAATGAAGCCTCTCTAAGAATGCAGCCCCTCTCTCTGAAGTGTTTGGGTCTCATTGTTCCAGCCACATGTGACTGGCTGCCTTCCCCTCAACACTTATTCCACTCTGCTCCATTCTGTTGGCAGGAATTTTGGAAGCAGCTGGGGAACCTGGGCGTATTGGGCATCACA
TCATAGTAGCCTTAAAGTTGGTTGGTATCATTTTCGTTTTAAAGATGATGAAACAGTGACTGAAAAGATCTAAGAAACTTGCCGAAAGTCCCACAGCTATGTAGTGGGATTGCATAGACTCCTGGACTCAGGGTACCAACCTGAGATGAGTTGTTCAAGAGCATTGACTTGGCTGGGTTCCGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGACAGGAGGATCACATGAGCCCAGGAGTTCAAGATCAGCTTGGGCAACATAGTGAGACTGCCCACCCCCACCCCGGCCCCATCTCTAATTAATTAATTAAATTTTAAAAATAACATTGACACAACATGGAGGAGGAAAATAGAGCAAGTGGAGAGGGGATAGAGACTTAATTCCATCAGCTCCCCTCTTTCCCCTCACCACTCTTCCTTTCCCTGTGTCCCGAACCCGTGTTTCTAAGTCCTGACTGCTATTATTCTGGTGTATTAAATACATACTATTTACTATTTAATACATCTTTTGTTGTTGTTTGTTTTCTCAAATTTTTTGTGGAGACAGGGTCTCCCTATGTTGCACAGGATGGTCTTGGACTCCTGGCCTCGAGCGATCTTCCCACCTAAGCTCCCAAAGTCCTAGGATTACAGGCATGAGCAACCATGCCCAGCCTATTTAATACATCTTATTTAATATATAGTATAATACGTAAATATGTACTATTTAATATTTAACACATATTAAATACAAATGGTCCCCAACTTACAATAGTTCAACTTAAGATTTTTCAACTTTATGATGGTGTGAAAGTGATAGACATTGAATAGAAACTGTACAATATTCAATAAATGATATCTAACACTGTCTTATAAAATATGCTTTGTGTTACATGATTGTGCCGTTATAAGCTATTATAAGTGTTCCAAGTACGTTTAAGGTCCACTAGTCTAAGCTATGATGTTTGGTAGGTTAGGTGTTTTTTTGTTTTCTGTTTTGAGACGGAGTGTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCAGCTCACCGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCATGCACCACCACGCCCAGCTAATTTTTGTATTTGTAGTAGAGACAGGATTTCTCCATGTTGGCCAGGCTGGTCTAAAACTCTCCGCCTCAGGTGACTCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCATCATGCCCGGCCTAAGTGTATTTTCAAAGTGCATTTTTGACTTACAATATTTTCCATTTATGATGGGTTTATCGAGAAGTAACCCCACTGTAAATCGAGGCGCATCTCCAATCTAGAAGGCAGCTACTCCTTAATAACCCCTTTCCCATAAAACATGAATCTAAATCTACAAACCTTGTTATATAATAAAGCAAGATGTACTCTGTTATGATCAGTGTGCACGTTAGAGCAAGCACTACTTTTCCGATCTTAATTATTCCAGAGATGCTTGACCAATTTACTGGGTACGTGGGCAGTTTTCTGATTGCTGTTTCCACACTCTGCTTTCCCACAGAGAGATTTCCGCAGTTAGGGGCTGCTATTTCAACGCAGGGAGATAAAAAGAAAAAAACACTTGCTCTTCTACCCCGCTAAAAACACTCATCCTAGGGAGCACGCCAGCATTTGCAGCGTTCGGGGCAGGGCCACTCGGCCTGCGGCCGTTGCACTGGCTGGAAGCTGGCAGGCGATCACGGTTGATTGGCTCGGGTGCGGTCCAAGGGCAGCAACGCCTTCGGCGGGCCGCCTAGGGTGATTGGCTGCTGCAGCCCACCCCCTAGCCGGTTTGGTGGGCGGCGAAGCCTGGATTGGTGGAGCTAAGAGCTGGCTCAGTTTCAGCGCTGGCTCTTCGTGCATGGCAGAGATGGCGACTGCGACTCGGCTGCTGGGGTGGCGTGTGGCGAGCTGGAGGCTGCGGCCGCCGCTTGCCGGCTTCGTTTCCCAGCGGGCCCACTCGCTTTTGCCCGTGGACAATGCAATCAATGGGCTAAGCGAGGAGCAGAGGCAGGTGAGGAGACTGACCCCCTTCCTGGCCCCAAGGCCTCCTTCCTGCCTGGTCCCCAAGGCCTCCTTCCTGCCTGGTCCCCATCGGCCCAGCGCCCACCCAGCCTTGGCTTTTGCCCGTGGGCCGTTGGGAGCGCCAGCGCGGGGGCGGGACGCGGGGCCTCCGACCTCGGGTCCAGTCCTCTGACCTCGGCCTCACGTCTGTGGAGTGAAGATTTGAGACCGTGGGACAGTACTGCTGGAAGTAGAGAGGAGGAGTCGAGGCTGGGAGAGCTCCTGAGAGACTGATGGTGTTTTGGTGGAGGATTGGCCAGGCTACCTACCGCTTGTGGCACAAGGGCCCTCAATCTGTATGTAGTTCACTTACACCTGAACAGGCTGAGGTATGCTTCTCACACCTGGGTGGTCATCGTAATCACCAGGGAGTCTTTTTTGTATAAACAGTTTGGGGGTTTTAAAAAGCCACAGTGAGCTCTCCTGTCGCTCTTCAGCCCATTGGGTCAAAACACAAAAGTTGAACAAGTACTTGAAAGAAGTAGTTGGAGGCCAGGCGCCGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCGAGGTGGGAGGATTGTTTGAGCTCAGGGGTTTGAGATCAGCCTAAGCAACATAGCCAGACCCCCATCTCATAAAAAATAGAAAAGAAGACGAAGTAGTATTTACAAATGGAGCAGAACCAGAGTCCTTCCTGAGGTTTCACTTGGAGGCTGGATGGAGTTGGCGGAGGTATGAGCCTCCCAGCAACTCCGTAGTTTATGTTTATAGCCAGCGAGCGCTCAGAGCTTCCGTGAACCACCTCAAGTGGAAAGGGTTCAATCCCTATTCTCAAGCTTTCCTGGCAAGAGGAGTTTCTTTTCTTTTTTCTTTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGTAATGGCGCGATCTCCGCTCACCACAACGTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAGGTAGCTGGGATTACAGGCATGCACCACCACGCCCGGCTAATTTTGTGTTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCCAACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCCAGCCGCCAAGAGGCGTTTCTAATCTCTTTGGGTAATCAGACCCTTTTAGCCAAAGGTTCGGGGGCTTAAAAGAGCCTGACAACTATTGAGATCTGGCAGCTGCCTGGAATGCAGCTGGAGCACAGAGGGTGGGAGGTGGGAAGGTGCTGGGGAAGCTAGGAGAGTCAGCTGGGGTCAGCTCCTGCAGGGCCTAGTAGGCCTGGGTGAGAAGCTTGTGTTTTATTCTAAGTACAGTGGAAACCAATGGAATGATTTTTATGTAAAGTGTGACGTTTTAAAAATTACCATCAAGCTGTCTAGGCTGAAGACCTTAAGAAAGAGGGGTGAAGATCATCTCTGAGGAGGCATAAACTACTGAGGCCTCTCAGTTTCAGTCTGATGCTGTTTGGGGAAGTTACTTGTGGCCTTTTCTCTTGAATGTGTCTGGGTAGTGGAGATGCTGTCTGCAGTGGCATCTGTTTACCTCTCTCCTATTAGCTTCGTCAGACCATGGCTAAGTTCCTTCAGGAGCACCTGGCCCCCAAGGCCCAGGAGATCGATCGCAGCAATGAGTTCAAGAACCTGCGAGTGAGTTGGGAGGTCCGGGCAGTCGGGGGCAGTCAGGGAGTGGGGCTGAGCTGCACTGCTGCCTGGAAGAGCTCACACAGTTTTCTGGTAAATGAAGCCTCTCTAAGAATGCAGCCCCTCTCTCTGAAGTGTTTGGGTCTCATTGTTCCAGCCACATGTGACTGGCTGCCTTCCCCTCAACACTTATTCCACTCTGCTCCATTCTGTTGGCAGGAATTTTGGAAGCAGCTGGGGAACCTGGGCGTATTGGGCATCACA
Task1_train_20523
A variant affecting Chromosome 15, within the gene IVD (isovaleryl-CoA dehydrogenase), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Isovaleric acidemia, type I
GTTGGTTGGTATCATTTTCGTTTTAAAGATGATGAAACAGTGACTGAAAAGATCTAAGAAACTTGCCGAAAGTCCCACAGCTATGTAGTGGGATTGCATAGACTCCTGGACTCAGGGTACCAACCTGAGATGAGTTGTTCAAGAGCATTGACTTGGCTGGGTTCCGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGACAGGAGGATCACATGAGCCCAGGAGTTCAAGATCAGCTTGGGCAACATAGTGAGACTGCCCACCCCCACCCCGGCCCCATCTCTAATTAATTAATTAAATTTTAAAAATAACATTGACACAACATGGAGGAGGAAAATAGAGCAAGTGGAGAGGGGATAGAGACTTAATTCCATCAGCTCCCCTCTTTCCCCTCACCACTCTTCCTTTCCCTGTGTCCCGAACCCGTGTTTCTAAGTCCTGACTGCTATTATTCTGGTGTATTAAATACATACTATTTACTATTTAATACATCTTTTGTTGTTGTTTGTTTTCTCAAATTTTTTGTGGAGACAGGGTCTCCCTATGTTGCACAGGATGGTCTTGGACTCCTGGCCTCGAGCGATCTTCCCACCTAAGCTCCCAAAGTCCTAGGATTACAGGCATGAGCAACCATGCCCAGCCTATTTAATACATCTTATTTAATATATAGTATAATACGTAAATATGTACTATTTAATATTTAACACATATTAAATACAAATGGTCCCCAACTTACAATAGTTCAACTTAAGATTTTTCAACTTTATGATGGTGTGAAAGTGATAGACATTGAATAGAAACTGTACAATATTCAATAAATGATATCTAACACTGTCTTATAAAATATGCTTTGTGTTACATGATTGTGCCGTTATAAGCTATTATAAGTGTTCCAAGTACGTTTAAGGTCCACTAGTCTAAGCTATGATGTTTGGTAGGTTAGGTGTTTTTTTGTTTTCTGTTTTGAGACGGAGTGTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCAGCTCACCGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCATGCACCACCACGCCCAGCTAATTTTTGTATTTGTAGTAGAGACAGGATTTCTCCATGTTGGCCAGGCTGGTCTAAAACTCTCCGCCTCAGGTGACTCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCATCATGCCCGGCCTAAGTGTATTTTCAAAGTGCATTTTTGACTTACAATATTTTCCATTTATGATGGGTTTATCGAGAAGTAACCCCACTGTAAATCGAGGCGCATCTCCAATCTAGAAGGCAGCTACTCCTTAATAACCCCTTTCCCATAAAACATGAATCTAAATCTACAAACCTTGTTATATAATAAAGCAAGATGTACTCTGTTATGATCAGTGTGCACGTTAGAGCAAGCACTACTTTTCCGATCTTAATTATTCCAGAGATGCTTGACCAATTTACTGGGTACGTGGGCAGTTTTCTGATTGCTGTTTCCACACTCTGCTTTCCCACAGAGAGATTTCCGCAGTTAGGGGCTGCTATTTCAACGCAGGGAGATAAAAAGAAAAAAACACTTGCTCTTCTACCCCGCTAAAAACACTCATCCTAGGGAGCACGCCAGCATTTGCAGCGTTCGGGGCAGGGCCACTCGGCCTGCGGCCGTTGCACTGGCTGGAAGCTGGCAGGCGATCACGGTTGATTGGCTCGGGTGCGGTCCAAGGGCAGCAACGCCTTCGGCGGGCCGCCTAGGGTGATTGGCTGCTGCAGCCCACCCCCTAGCCGGTTTGGTGGGCGGCGAAGCCTGGATTGGTGGAGCTAAGAGCTGGCTCAGTTTCAGCGCTGGCTCTTCGTGCATGGCAGAGATGGCGACTGCGACTCGGCTGCTGGGGTGGCGTGTGGCGAGCTGGAGGCTGCGGCCGCCGCTTGCCGGCTTCGTTTCCCAGCGGGCCCACTCGCTTTTGCCCGTGGACGATGCAATCAATGGGCTAAGCGAGGAGCAGAGGCAGGTGAGGAGACTGACCCCCTTCCTGGCCCCAAGGCCTCCTTCCTGCCTGGTCCCCAAGGCCTCCTTCCTGCCTGGTCCCCATCGGCCCAGCGCCCACCCAGCCTTGGCTTTTGCCCGTGGGCCGTTGGGAGCGCCAGCGCGGGGGCGGGACGCGGGGCCTCCGACCTCGGGTCCAGTCCTCTGACCTCGGCCTCACGTCTGTGGAGTGAAGATTTGAGACCGTGGGACAGTACTGCTGGAAGTAGAGAGGAGGAGTCGAGGCTGGGAGAGCTCCTGAGAGACTGATGGTGTTTTGGTGGAGGATTGGCCAGGCTACCTACCGCTTGTGGCACAAGGGCCCTCAATCTGTATGTAGTTCACTTACACCTGAACAGGCTGAGGTATGCTTCTCACACCTGGGTGGTCATCGTAATCACCAGGGAGTCTTTTTTGTATAAACAGTTTGGGGGTTTTAAAAAGCCACAGTGAGCTCTCCTGTCGCTCTTCAGCCCATTGGGTCAAAACACAAAAGTTGAACAAGTACTTGAAAGAAGTAGTTGGAGGCCAGGCGCCGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCGAGGTGGGAGGATTGTTTGAGCTCAGGGGTTTGAGATCAGCCTAAGCAACATAGCCAGACCCCCATCTCATAAAAAATAGAAAAGAAGACGAAGTAGTATTTACAAATGGAGCAGAACCAGAGTCCTTCCTGAGGTTTCACTTGGAGGCTGGATGGAGTTGGCGGAGGTATGAGCCTCCCAGCAACTCCGTAGTTTATGTTTATAGCCAGCGAGCGCTCAGAGCTTCCGTGAACCACCTCAAGTGGAAAGGGTTCAATCCCTATTCTCAAGCTTTCCTGGCAAGAGGAGTTTCTTTTCTTTTTTCTTTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGTAATGGCGCGATCTCCGCTCACCACAACGTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAGGTAGCTGGGATTACAGGCATGCACCACCACGCCCGGCTAATTTTGTGTTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCCAACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCCAGCCGCCAAGAGGCGTTTCTAATCTCTTTGGGTAATCAGACCCTTTTAGCCAAAGGTTCGGGGGCTTAAAAGAGCCTGACAACTATTGAGATCTGGCAGCTGCCTGGAATGCAGCTGGAGCACAGAGGGTGGGAGGTGGGAAGGTGCTGGGGAAGCTAGGAGAGTCAGCTGGGGTCAGCTCCTGCAGGGCCTAGTAGGCCTGGGTGAGAAGCTTGTGTTTTATTCTAAGTACAGTGGAAACCAATGGAATGATTTTTATGTAAAGTGTGACGTTTTAAAAATTACCATCAAGCTGTCTAGGCTGAAGACCTTAAGAAAGAGGGGTGAAGATCATCTCTGAGGAGGCATAAACTACTGAGGCCTCTCAGTTTCAGTCTGATGCTGTTTGGGGAAGTTACTTGTGGCCTTTTCTCTTGAATGTGTCTGGGTAGTGGAGATGCTGTCTGCAGTGGCATCTGTTTACCTCTCTCCTATTAGCTTCGTCAGACCATGGCTAAGTTCCTTCAGGAGCACCTGGCCCCCAAGGCCCAGGAGATCGATCGCAGCAATGAGTTCAAGAACCTGCGAGTGAGTTGGGAGGTCCGGGCAGTCGGGGGCAGTCAGGGAGTGGGGCTGAGCTGCACTGCTGCCTGGAAGAGCTCACACAGTTTTCTGGTAAATGAAGCCTCTCTAAGAATGCAGCCCCTCTCTCTGAAGTGTTTGGGTCTCATTGTTCCAGCCACATGTGACTGGCTGCCTTCCCCTCAACACTTATTCCACTCTGCTCCATTCTGTTGGCAGGAATTTTGGAAGCAGCTGGGGAACCTGGGCGTATTGGGCATCACAGCCCCTGGTGAGTATA
GTTGGTTGGTATCATTTTCGTTTTAAAGATGATGAAACAGTGACTGAAAAGATCTAAGAAACTTGCCGAAAGTCCCACAGCTATGTAGTGGGATTGCATAGACTCCTGGACTCAGGGTACCAACCTGAGATGAGTTGTTCAAGAGCATTGACTTGGCTGGGTTCCGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGACAGGAGGATCACATGAGCCCAGGAGTTCAAGATCAGCTTGGGCAACATAGTGAGACTGCCCACCCCCACCCCGGCCCCATCTCTAATTAATTAATTAAATTTTAAAAATAACATTGACACAACATGGAGGAGGAAAATAGAGCAAGTGGAGAGGGGATAGAGACTTAATTCCATCAGCTCCCCTCTTTCCCCTCACCACTCTTCCTTTCCCTGTGTCCCGAACCCGTGTTTCTAAGTCCTGACTGCTATTATTCTGGTGTATTAAATACATACTATTTACTATTTAATACATCTTTTGTTGTTGTTTGTTTTCTCAAATTTTTTGTGGAGACAGGGTCTCCCTATGTTGCACAGGATGGTCTTGGACTCCTGGCCTCGAGCGATCTTCCCACCTAAGCTCCCAAAGTCCTAGGATTACAGGCATGAGCAACCATGCCCAGCCTATTTAATACATCTTATTTAATATATAGTATAATACGTAAATATGTACTATTTAATATTTAACACATATTAAATACAAATGGTCCCCAACTTACAATAGTTCAACTTAAGATTTTTCAACTTTATGATGGTGTGAAAGTGATAGACATTGAATAGAAACTGTACAATATTCAATAAATGATATCTAACACTGTCTTATAAAATATGCTTTGTGTTACATGATTGTGCCGTTATAAGCTATTATAAGTGTTCCAAGTACGTTTAAGGTCCACTAGTCTAAGCTATGATGTTTGGTAGGTTAGGTGTTTTTTTGTTTTCTGTTTTGAGACGGAGTGTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCAGCTCACCGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCATGCACCACCACGCCCAGCTAATTTTTGTATTTGTAGTAGAGACAGGATTTCTCCATGTTGGCCAGGCTGGTCTAAAACTCTCCGCCTCAGGTGACTCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCATCATGCCCGGCCTAAGTGTATTTTCAAAGTGCATTTTTGACTTACAATATTTTCCATTTATGATGGGTTTATCGAGAAGTAACCCCACTGTAAATCGAGGCGCATCTCCAATCTAGAAGGCAGCTACTCCTTAATAACCCCTTTCCCATAAAACATGAATCTAAATCTACAAACCTTGTTATATAATAAAGCAAGATGTACTCTGTTATGATCAGTGTGCACGTTAGAGCAAGCACTACTTTTCCGATCTTAATTATTCCAGAGATGCTTGACCAATTTACTGGGTACGTGGGCAGTTTTCTGATTGCTGTTTCCACACTCTGCTTTCCCACAGAGAGATTTCCGCAGTTAGGGGCTGCTATTTCAACGCAGGGAGATAAAAAGAAAAAAACACTTGCTCTTCTACCCCGCTAAAAACACTCATCCTAGGGAGCACGCCAGCATTTGCAGCGTTCGGGGCAGGGCCACTCGGCCTGCGGCCGTTGCACTGGCTGGAAGCTGGCAGGCGATCACGGTTGATTGGCTCGGGTGCGGTCCAAGGGCAGCAACGCCTTCGGCGGGCCGCCTAGGGTGATTGGCTGCTGCAGCCCACCCCCTAGCCGGTTTGGTGGGCGGCGAAGCCTGGATTGGTGGAGCTAAGAGCTGGCTCAGTTTCAGCGCTGGCTCTTCGTGCATGGCAGAGATGGCGACTGCGACTCGGCTGCTGGGGTGGCGTGTGGCGAGCTGGAGGCTGCGGCCGCCGCTTGCCGGCTTCGTTTCCCAGCGGGCCCACTCGCTTTTGCCCGTGGACGATGCAATCAATGGGCCAAGCGAGGAGCAGAGGCAGGTGAGGAGACTGACCCCCTTCCTGGCCCCAAGGCCTCCTTCCTGCCTGGTCCCCAAGGCCTCCTTCCTGCCTGGTCCCCATCGGCCCAGCGCCCACCCAGCCTTGGCTTTTGCCCGTGGGCCGTTGGGAGCGCCAGCGCGGGGGCGGGACGCGGGGCCTCCGACCTCGGGTCCAGTCCTCTGACCTCGGCCTCACGTCTGTGGAGTGAAGATTTGAGACCGTGGGACAGTACTGCTGGAAGTAGAGAGGAGGAGTCGAGGCTGGGAGAGCTCCTGAGAGACTGATGGTGTTTTGGTGGAGGATTGGCCAGGCTACCTACCGCTTGTGGCACAAGGGCCCTCAATCTGTATGTAGTTCACTTACACCTGAACAGGCTGAGGTATGCTTCTCACACCTGGGTGGTCATCGTAATCACCAGGGAGTCTTTTTTGTATAAACAGTTTGGGGGTTTTAAAAAGCCACAGTGAGCTCTCCTGTCGCTCTTCAGCCCATTGGGTCAAAACACAAAAGTTGAACAAGTACTTGAAAGAAGTAGTTGGAGGCCAGGCGCCGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCGAGGTGGGAGGATTGTTTGAGCTCAGGGGTTTGAGATCAGCCTAAGCAACATAGCCAGACCCCCATCTCATAAAAAATAGAAAAGAAGACGAAGTAGTATTTACAAATGGAGCAGAACCAGAGTCCTTCCTGAGGTTTCACTTGGAGGCTGGATGGAGTTGGCGGAGGTATGAGCCTCCCAGCAACTCCGTAGTTTATGTTTATAGCCAGCGAGCGCTCAGAGCTTCCGTGAACCACCTCAAGTGGAAAGGGTTCAATCCCTATTCTCAAGCTTTCCTGGCAAGAGGAGTTTCTTTTCTTTTTTCTTTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGTAATGGCGCGATCTCCGCTCACCACAACGTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAGGTAGCTGGGATTACAGGCATGCACCACCACGCCCGGCTAATTTTGTGTTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCCAACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCCAGCCGCCAAGAGGCGTTTCTAATCTCTTTGGGTAATCAGACCCTTTTAGCCAAAGGTTCGGGGGCTTAAAAGAGCCTGACAACTATTGAGATCTGGCAGCTGCCTGGAATGCAGCTGGAGCACAGAGGGTGGGAGGTGGGAAGGTGCTGGGGAAGCTAGGAGAGTCAGCTGGGGTCAGCTCCTGCAGGGCCTAGTAGGCCTGGGTGAGAAGCTTGTGTTTTATTCTAAGTACAGTGGAAACCAATGGAATGATTTTTATGTAAAGTGTGACGTTTTAAAAATTACCATCAAGCTGTCTAGGCTGAAGACCTTAAGAAAGAGGGGTGAAGATCATCTCTGAGGAGGCATAAACTACTGAGGCCTCTCAGTTTCAGTCTGATGCTGTTTGGGGAAGTTACTTGTGGCCTTTTCTCTTGAATGTGTCTGGGTAGTGGAGATGCTGTCTGCAGTGGCATCTGTTTACCTCTCTCCTATTAGCTTCGTCAGACCATGGCTAAGTTCCTTCAGGAGCACCTGGCCCCCAAGGCCCAGGAGATCGATCGCAGCAATGAGTTCAAGAACCTGCGAGTGAGTTGGGAGGTCCGGGCAGTCGGGGGCAGTCAGGGAGTGGGGCTGAGCTGCACTGCTGCCTGGAAGAGCTCACACAGTTTTCTGGTAAATGAAGCCTCTCTAAGAATGCAGCCCCTCTCTCTGAAGTGTTTGGGTCTCATTGTTCCAGCCACATGTGACTGGCTGCCTTCCCCTCAACACTTATTCCACTCTGCTCCATTCTGTTGGCAGGAATTTTGGAAGCAGCTGGGGAACCTGGGCGTATTGGGCATCACAGCCCCTGGTGAGTATA
Task1_train_20524
This variant impacts the gene IVD (isovaleryl-CoA dehydrogenase) on Chromosome 15. Is the change likely to result in a pathogenic outcome?
Pathogenic; Inborn genetic diseases
ACTCATTAACTCACGTTTTTGTAAAATATTTTAAAAATGAGTTATTCATTTTTAGCATTAATGATGCTAAGAAAAAAAAACAAAACATCTGAATCCACTGATGGAATCCCGACTCAGTAGAGAGAAGGCAGTTCTGCTTGAGTATGAGTATTTTCTCCCCTGAGGTGTAACTGAAATCTGACATGGTGGAGCACTGTGGGAGAGCCAGCACAGCCATCATGTACTAACCAGACCAGGGGCATGGATTTGTTGTTTGGGGTTTTTTTTTGTTTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTGAGAAGGAGTCTTGGCTCTGTCACCCAGGCTAGAGTGCAGTGGCGTGATCTCAGCTCACGGCAGCCTCCACCTCCTGGGTTCCAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCCTGCCCAGCTAAATTTTTTGTTTGTTTTTTTGAGATGGAGTGTCGCTCTTGTTGCCCAGGGCTGGAGTGCAATGGCGCGATCTTGGCTTACTGCAACCTCCGCCCCCTGGGTTCAAGTGATTCTCCTGTCTCAGCCTTCTGAGTAGCTGGGATGACAGGCACACACCGCCCAGCTAATTTTGTATTTTTAGTAGAGACAGATGGGGTTTCACCATGTTGGCCAGGCTGCTCTCGAACTCCTGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCCAGGATTATAGGCCTGAGCCACCTTGCCTGGCCAGGGGCATGGATTTGATCAACAGTTAGGTTTGCTGTCTGCCTCAGCCATATACCACGCCTATCACTGACAGCCCAAAAAAGTGTACTTTAATTACAGGGAGCATCCAGGGAGGGGGAGCTGTGCAGCTCCTTCTTTGTTGACAGGAAAAAATTCAGCTAGCATTAAAGGCAGGTCAGTAGTGTCAACCTGTTTTCCTGCCCACACCTCCCAAGGCCATCCAGTCTCCTGGCTTTACTGGGTGGAGAGGTGCTCAGCAGCTTCTGTCACTAGCTCTGAATGGCCTGTCTCCTGGACAAAGAAGCTTTCACGGACTACTCTGCAGGGAGGTGACATTGGACCAGAGCTGACTCCACCTGGGGGAAAGAGTAATTCTCTGGTTTCTTTATAGGTGCCTGTGTAGAAAGAGTCAGGGAGGGATTGGGTGACTTCTAGACCAATTAACTTTTCTTCTTTCCCATCCAAGGGAGTCCAGAGAGGGAAGGGAAAGATCTAACAACTCTAGCCTTTGTGGTTGGCCTCGTGGATGGGGTGGGAGTCCTGGCAGCTCCACTTCTGACTGGAAGGGGTTCACTTGATCCTTTTCTTTCACCTGGAACCTTAGTTGAATAAAGGTCAAGTGACATATTTTAGTGCCTTACTTGAGAGCCATGTTTCCAAATCTAGTACCTTTGATAAAAGTGAGGAGGCTGTGGACAGCTCTCTCCCTCTGACCAGCACTTATCCTGGCAGCTGCCAACATCCTGGGCCATGAGAATAAGGGTGTCTACGTGCTGATGAGTGGGCTGGACCTGGAGCGGCTGGTGCTGGCCGGGGGGCCTCTTGGGTAAGTGTGAGAGGCTTGAGGGAAGCTGGGCTCTGTCGGCCTCCTCGGCAGGTGACCCACCATGAGCAGCAGCAGCCTTCCCCTTGCGGGGCCAAAGGGAGCTGCCTCTTGGCCCTGCTCTCTCCTGGGAGATGAAAGGAACCTCCTCTTCCCATGTTGAATTTCTTCCCACAGTGGGGAAATATCATTAAGTAACAGACAAAAGGCCTGAGGAGCAGGGTGGCTTACTCGGCTGTGAAACGACACCTGGGCTGTCACGCCCCTGCACCTCTGGCCAGTCAGTGCCGTAACTGTGGCAAGACTTTCTGAAGTTGCTTTTCTCCTCCCTGGGATTCTGGCCTTCCCACGCTAGCATTTTGCCACCACACCCGGTGGTGGGATGAGGAGGTGCCCACGGGGCCTTTCTCCTTTCTGACAGGCTCATGCAAGCGGTCCTGGACCACACCATTCCCTACCTGCACGTGAGGGAAGCCTTTGGCCAGAAGATCGGCCACTTCCAGGTGAGCCGAGTGCTTTTGCTGACATGTACTCTTCAACTGGGCTAAAGTTTTCTTTGAAAAGAGAGGAAGTGAGGTGGGCACCGTGGATGGTTACTGTCTCCTCTAGCAAATTGAGCTTGACTGCTTGGAATGCAGTCTTCCTCAGCATGCAGCCTGACTCTGGAAGTCATCAGGAAGTTCACCACATTGCCACCTCGATTCCTGTGTGAGGTGGATGAACTAGACATTGTAAGGTTGGAGAGCAAAGCGTGCAAGTTGTGGGGGCAGAAGGGAAAGAGGTTGCTATTTGTAGTTAGACCTTCTGGTCCGAAGAAGCTGCTGGAAGGTAATAAGCATTGGAGTAAATGGTGCCTTGGGAGCCATGCCTTTCGGAGGCAGTGATGGCCACTTCGGGGTGTCATGCGGGCTGTGGAACAGCCACTCTGTGGCCCTAACTCCCACACCTGCCCCCATCTCCATCATCCTGAGTAAATCCCATCTCCTCTCCATGCCCCTGCTTCCTCATCCTTGGCTGTCTTGTTGCCATTGCTGACCTGCTTTTGGTAACTGAGAGAGTGTTCCAGCATGTTGACCTGTGACATCCCTTTGTGCCCAGTTGATGCAGGGGAAGATGGCTGACATGTACACCCGCCTCATGGCGTGTCGGCAGTATGTCTACAATGTCGCCAAGGCCTGCGATGAGGGCCATTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGTAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCGCATGCCGGGCATGATGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAACAAAGATTGCACCATTGCACTCCAGCCTAGGTGACAGAGCGAGAGGCTGTCTCAAAAAAAAGCAATTTCCTCTCCACTTCTCCACTCCTCACTATGTGCTTATGCTAGGCCCAGCTGAGCTGGGACCTTCGGGCTCTTTCTGTCCCAGTTACAAGGAGGAAATGGAAAGCAAATGAGAAAACTGCTAGATGCCAGGAGTTGCTGCTGCCTTCGGCAACACCCCCCTCTCATCCTCCCCGCCTCATAGATGCTAGGAAATGGGAAAGGGAGATGTGGCTGGGCACAGTGGCTCACACCTGTAATTCCAACACTTTAGGAGACTGAGGCCAGTGAATCACCTGAGATCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAAAAAATTAGCCAAGTGTGGTGGCAGGAGCCTGTAATCCCAGCTATTTGGAAGGCTGAGGCTGGAGAATCTCTTGAACCCAGGAGGCGGAGGTTGCAGTGACCGGAGATCGCGCCATTGCACTCCAGCCTGAGTGACAAGAGTGAAACTCCGTCTCGGAAAAAAAAAAAAAAAAAAAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGCAGTGGTGCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTTGGATGCGGAGGTTGCAGAGAGCCAATATCATGCCACTGCACTCCAGCCTAGGCCACAGAGCATGACTC
ACTCATTAACTCACGTTTTTGTAAAATATTTTAAAAATGAGTTATTCATTTTTAGCATTAATGATGCTAAGAAAAAAAAACAAAACATCTGAATCCACTGATGGAATCCCGACTCAGTAGAGAGAAGGCAGTTCTGCTTGAGTATGAGTATTTTCTCCCCTGAGGTGTAACTGAAATCTGACATGGTGGAGCACTGTGGGAGAGCCAGCACAGCCATCATGTACTAACCAGACCAGGGGCATGGATTTGTTGTTTGGGGTTTTTTTTTGTTTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTGAGAAGGAGTCTTGGCTCTGTCACCCAGGCTAGAGTGCAGTGGCGTGATCTCAGCTCACGGCAGCCTCCACCTCCTGGGTTCCAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCCTGCCCAGCTAAATTTTTTGTTTGTTTTTTTGAGATGGAGTGTCGCTCTTGTTGCCCAGGGCTGGAGTGCAATGGCGCGATCTTGGCTTACTGCAACCTCCGCCCCCTGGGTTCAAGTGATTCTCCTGTCTCAGCCTTCTGAGTAGCTGGGATGACAGGCACACACCGCCCAGCTAATTTTGTATTTTTAGTAGAGACAGATGGGGTTTCACCATGTTGGCCAGGCTGCTCTCGAACTCCTGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCCAGGATTATAGGCCTGAGCCACCTTGCCTGGCCAGGGGCATGGATTTGATCAACAGTTAGGTTTGCTGTCTGCCTCAGCCATATACCACGCCTATCACTGACAGCCCAAAAAAGTGTACTTTAATTACAGGGAGCATCCAGGGAGGGGGAGCTGTGCAGCTCCTTCTTTGTTGACAGGAAAAAATTCAGCTAGCATTAAAGGCAGGTCAGTAGTGTCAACCTGTTTTCCTGCCCACACCTCCCAAGGCCATCCAGTCTCCTGGCTTTACTGGGTGGAGAGGTGCTCAGCAGCTTCTGTCACTAGCTCTGAATGGCCTGTCTCCTGGACAAAGAAGCTTTCACGGACTACTCTGCAGGGAGGTGACATTGGACCAGAGCTGACTCCACCTGGGGGAAAGAGTAATTCTCTGGTTTCTTTATAGGTGCCTGTGTAGAAAGAGTCAGGGAGGGATTGGGTGACTTCTAGACCAATTAACTTTTCTTCTTTCCCATCCAAGGGAGTCCAGAGAGGGAAGGGAAAGATCTAACAACTCTAGCCTTTGTGGTTGGCCTCGTGGATGGGGTGGGAGTCCTGGCAGCTCCACTTCTGACTGGAAGGGGTTCACTTGATCCTTTTCTTTCACCTGGAACCTTAGTTGAATAAAGGTCAAGTGACATATTTTAGTGCCTTACTTGAGAGCCATGTTTCCAAATCTAGTACCTTTGATAAAAGTGAGGAGGCTGTGGACAGCTCTCTCCCTCTGACCAGCACTTATCCTGGCAGCTGCCAACATCCTGGGCCATGAGAATAAGGGTGTCTACGTGCTGATGAGTGGGCTGGACCTGGAGCGGCTGGTGCTGGCCGGGGGGCCTCTTGGGTAAGTGTGAGAGGCTTGAGGGAAGCTGGGCTCTGTCGGCCTCCTCGGCAGGTGACCCACCATGAGCAGCAGCAGCCTTCCCCTTGCGGGGCCAAAGGGAGCTGCCTCTTGGCCCTGCTCTCTCCTGGGAGATGAAAGGAACCTCCTCTTCCCATGTTGAATTTCTTCCCACAGTGGGGAAATATCATTAAGTAACAGACAAAAGGCCTGAGGAGCAGGGTGGCTTACTCGGCTGTGAAACGACACCTGGGCTGTCACGCCCCTGCACCTCTGGCCAGTCAGTGCCGTAACTGTGGCAAGACTTTCTGAAGTTGCTTTTCTCCTCCCTGGGATTCTGGCCTTCCCACGCTAGCATTTTGCCACCACACCCGGTGGTGGGATGAGGAGGTGCCCACGGGGCCTTTCTCCTTTCTGACAGGCTCATGCAAGCGGTCCTGGACCACACCATTCCCTACCTGCACGTGAGGGAAGTCTTTGGCCAGAAGATCGGCCACTTCCAGGTGAGCCGAGTGCTTTTGCTGACATGTACTCTTCAACTGGGCTAAAGTTTTCTTTGAAAAGAGAGGAAGTGAGGTGGGCACCGTGGATGGTTACTGTCTCCTCTAGCAAATTGAGCTTGACTGCTTGGAATGCAGTCTTCCTCAGCATGCAGCCTGACTCTGGAAGTCATCAGGAAGTTCACCACATTGCCACCTCGATTCCTGTGTGAGGTGGATGAACTAGACATTGTAAGGTTGGAGAGCAAAGCGTGCAAGTTGTGGGGGCAGAAGGGAAAGAGGTTGCTATTTGTAGTTAGACCTTCTGGTCCGAAGAAGCTGCTGGAAGGTAATAAGCATTGGAGTAAATGGTGCCTTGGGAGCCATGCCTTTCGGAGGCAGTGATGGCCACTTCGGGGTGTCATGCGGGCTGTGGAACAGCCACTCTGTGGCCCTAACTCCCACACCTGCCCCCATCTCCATCATCCTGAGTAAATCCCATCTCCTCTCCATGCCCCTGCTTCCTCATCCTTGGCTGTCTTGTTGCCATTGCTGACCTGCTTTTGGTAACTGAGAGAGTGTTCCAGCATGTTGACCTGTGACATCCCTTTGTGCCCAGTTGATGCAGGGGAAGATGGCTGACATGTACACCCGCCTCATGGCGTGTCGGCAGTATGTCTACAATGTCGCCAAGGCCTGCGATGAGGGCCATTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGTAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCGCATGCCGGGCATGATGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAACAAAGATTGCACCATTGCACTCCAGCCTAGGTGACAGAGCGAGAGGCTGTCTCAAAAAAAAGCAATTTCCTCTCCACTTCTCCACTCCTCACTATGTGCTTATGCTAGGCCCAGCTGAGCTGGGACCTTCGGGCTCTTTCTGTCCCAGTTACAAGGAGGAAATGGAAAGCAAATGAGAAAACTGCTAGATGCCAGGAGTTGCTGCTGCCTTCGGCAACACCCCCCTCTCATCCTCCCCGCCTCATAGATGCTAGGAAATGGGAAAGGGAGATGTGGCTGGGCACAGTGGCTCACACCTGTAATTCCAACACTTTAGGAGACTGAGGCCAGTGAATCACCTGAGATCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAAAAAATTAGCCAAGTGTGGTGGCAGGAGCCTGTAATCCCAGCTATTTGGAAGGCTGAGGCTGGAGAATCTCTTGAACCCAGGAGGCGGAGGTTGCAGTGACCGGAGATCGCGCCATTGCACTCCAGCCTGAGTGACAAGAGTGAAACTCCGTCTCGGAAAAAAAAAAAAAAAAAAAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGCAGTGGTGCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTTGGATGCGGAGGTTGCAGAGAGCCAATATCATGCCACTGCACTCCAGCCTAGGCCACAGAGCATGACTC
Task1_train_20525
This variant impacts the gene IVD (isovaleryl-CoA dehydrogenase) on Chromosome 15. Is the change likely to result in a pathogenic outcome?
Pathogenic; Isovaleryl-CoA dehydrogenase deficiency
ACTCATTAACTCACGTTTTTGTAAAATATTTTAAAAATGAGTTATTCATTTTTAGCATTAATGATGCTAAGAAAAAAAAACAAAACATCTGAATCCACTGATGGAATCCCGACTCAGTAGAGAGAAGGCAGTTCTGCTTGAGTATGAGTATTTTCTCCCCTGAGGTGTAACTGAAATCTGACATGGTGGAGCACTGTGGGAGAGCCAGCACAGCCATCATGTACTAACCAGACCAGGGGCATGGATTTGTTGTTTGGGGTTTTTTTTTGTTTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTGAGAAGGAGTCTTGGCTCTGTCACCCAGGCTAGAGTGCAGTGGCGTGATCTCAGCTCACGGCAGCCTCCACCTCCTGGGTTCCAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCCTGCCCAGCTAAATTTTTTGTTTGTTTTTTTGAGATGGAGTGTCGCTCTTGTTGCCCAGGGCTGGAGTGCAATGGCGCGATCTTGGCTTACTGCAACCTCCGCCCCCTGGGTTCAAGTGATTCTCCTGTCTCAGCCTTCTGAGTAGCTGGGATGACAGGCACACACCGCCCAGCTAATTTTGTATTTTTAGTAGAGACAGATGGGGTTTCACCATGTTGGCCAGGCTGCTCTCGAACTCCTGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCCAGGATTATAGGCCTGAGCCACCTTGCCTGGCCAGGGGCATGGATTTGATCAACAGTTAGGTTTGCTGTCTGCCTCAGCCATATACCACGCCTATCACTGACAGCCCAAAAAAGTGTACTTTAATTACAGGGAGCATCCAGGGAGGGGGAGCTGTGCAGCTCCTTCTTTGTTGACAGGAAAAAATTCAGCTAGCATTAAAGGCAGGTCAGTAGTGTCAACCTGTTTTCCTGCCCACACCTCCCAAGGCCATCCAGTCTCCTGGCTTTACTGGGTGGAGAGGTGCTCAGCAGCTTCTGTCACTAGCTCTGAATGGCCTGTCTCCTGGACAAAGAAGCTTTCACGGACTACTCTGCAGGGAGGTGACATTGGACCAGAGCTGACTCCACCTGGGGGAAAGAGTAATTCTCTGGTTTCTTTATAGGTGCCTGTGTAGAAAGAGTCAGGGAGGGATTGGGTGACTTCTAGACCAATTAACTTTTCTTCTTTCCCATCCAAGGGAGTCCAGAGAGGGAAGGGAAAGATCTAACAACTCTAGCCTTTGTGGTTGGCCTCGTGGATGGGGTGGGAGTCCTGGCAGCTCCACTTCTGACTGGAAGGGGTTCACTTGATCCTTTTCTTTCACCTGGAACCTTAGTTGAATAAAGGTCAAGTGACATATTTTAGTGCCTTACTTGAGAGCCATGTTTCCAAATCTAGTACCTTTGATAAAAGTGAGGAGGCTGTGGACAGCTCTCTCCCTCTGACCAGCACTTATCCTGGCAGCTGCCAACATCCTGGGCCATGAGAATAAGGGTGTCTACGTGCTGATGAGTGGGCTGGACCTGGAGCGGCTGGTGCTGGCCGGGGGGCCTCTTGGGTAAGTGTGAGAGGCTTGAGGGAAGCTGGGCTCTGTCGGCCTCCTCGGCAGGTGACCCACCATGAGCAGCAGCAGCCTTCCCCTTGCGGGGCCAAAGGGAGCTGCCTCTTGGCCCTGCTCTCTCCTGGGAGATGAAAGGAACCTCCTCTTCCCATGTTGAATTTCTTCCCACAGTGGGGAAATATCATTAAGTAACAGACAAAAGGCCTGAGGAGCAGGGTGGCTTACTCGGCTGTGAAACGACACCTGGGCTGTCACGCCCCTGCACCTCTGGCCAGTCAGTGCCGTAACTGTGGCAAGACTTTCTGAAGTTGCTTTTCTCCTCCCTGGGATTCTGGCCTTCCCACGCTAGCATTTTGCCACCACACCCGGTGGTGGGATGAGGAGGTGCCCACGGGGCCTTTCTCCTTTCTGACAGGCTCATGCAAGCGGTCCTGGACCACACCATTCCCTACCTGCACGTGAGGGAAGCCTTTGGCCAGAAGATCGGCCACTTCCAGGTGAGCCGAGTGCTTTTGCTGACATGTACTCTTCAACTGGGCTAAAGTTTTCTTTGAAAAGAGAGGAAGTGAGGTGGGCACCGTGGATGGTTACTGTCTCCTCTAGCAAATTGAGCTTGACTGCTTGGAATGCAGTCTTCCTCAGCATGCAGCCTGACTCTGGAAGTCATCAGGAAGTTCACCACATTGCCACCTCGATTCCTGTGTGAGGTGGATGAACTAGACATTGTAAGGTTGGAGAGCAAAGCGTGCAAGTTGTGGGGGCAGAAGGGAAAGAGGTTGCTATTTGTAGTTAGACCTTCTGGTCCGAAGAAGCTGCTGGAAGGTAATAAGCATTGGAGTAAATGGTGCCTTGGGAGCCATGCCTTTCGGAGGCAGTGATGGCCACTTCGGGGTGTCATGCGGGCTGTGGAACAGCCACTCTGTGGCCCTAACTCCCACACCTGCCCCCATCTCCATCATCCTGAGTAAATCCCATCTCCTCTCCATGCCCCTGCTTCCTCATCCTTGGCTGTCTTGTTGCCATTGCTGACCTGCTTTTGGTAACTGAGAGAGTGTTCCAGCATGTTGACCTGTGACATCCCTTTGTGCCCAGTTGATGCAGGGGAAGATGGCTGACATGTACACCCGCCTCATGGCGTGTCGGCAGTATGTCTACAATGTCGCCAAGGCCTGCGATGAGGGCCATTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGTAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCGCATGCCGGGCATGATGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAACAAAGATTGCACCATTGCACTCCAGCCTAGGTGACAGAGCGAGAGGCTGTCTCAAAAAAAAGCAATTTCCTCTCCACTTCTCCACTCCTCACTATGTGCTTATGCTAGGCCCAGCTGAGCTGGGACCTTCGGGCTCTTTCTGTCCCAGTTACAAGGAGGAAATGGAAAGCAAATGAGAAAACTGCTAGATGCCAGGAGTTGCTGCTGCCTTCGGCAACACCCCCCTCTCATCCTCCCCGCCTCATAGATGCTAGGAAATGGGAAAGGGAGATGTGGCTGGGCACAGTGGCTCACACCTGTAATTCCAACACTTTAGGAGACTGAGGCCAGTGAATCACCTGAGATCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAAAAAATTAGCCAAGTGTGGTGGCAGGAGCCTGTAATCCCAGCTATTTGGAAGGCTGAGGCTGGAGAATCTCTTGAACCCAGGAGGCGGAGGTTGCAGTGACCGGAGATCGCGCCATTGCACTCCAGCCTGAGTGACAAGAGTGAAACTCCGTCTCGGAAAAAAAAAAAAAAAAAAAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGCAGTGGTGCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTTGGATGCGGAGGTTGCAGAGAGCCAATATCATGCCACTGCACTCCAGCCTAGGCCACAGAGCATGACTC
ACTCATTAACTCACGTTTTTGTAAAATATTTTAAAAATGAGTTATTCATTTTTAGCATTAATGATGCTAAGAAAAAAAAACAAAACATCTGAATCCACTGATGGAATCCCGACTCAGTAGAGAGAAGGCAGTTCTGCTTGAGTATGAGTATTTTCTCCCCTGAGGTGTAACTGAAATCTGACATGGTGGAGCACTGTGGGAGAGCCAGCACAGCCATCATGTACTAACCAGACCAGGGGCATGGATTTGTTGTTTGGGGTTTTTTTTTGTTTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTGAGAAGGAGTCTTGGCTCTGTCACCCAGGCTAGAGTGCAGTGGCGTGATCTCAGCTCACGGCAGCCTCCACCTCCTGGGTTCCAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCCTGCCCAGCTAAATTTTTTGTTTGTTTTTTTGAGATGGAGTGTCGCTCTTGTTGCCCAGGGCTGGAGTGCAATGGCGCGATCTTGGCTTACTGCAACCTCCGCCCCCTGGGTTCAAGTGATTCTCCTGTCTCAGCCTTCTGAGTAGCTGGGATGACAGGCACACACCGCCCAGCTAATTTTGTATTTTTAGTAGAGACAGATGGGGTTTCACCATGTTGGCCAGGCTGCTCTCGAACTCCTGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCCAGGATTATAGGCCTGAGCCACCTTGCCTGGCCAGGGGCATGGATTTGATCAACAGTTAGGTTTGCTGTCTGCCTCAGCCATATACCACGCCTATCACTGACAGCCCAAAAAAGTGTACTTTAATTACAGGGAGCATCCAGGGAGGGGGAGCTGTGCAGCTCCTTCTTTGTTGACAGGAAAAAATTCAGCTAGCATTAAAGGCAGGTCAGTAGTGTCAACCTGTTTTCCTGCCCACACCTCCCAAGGCCATCCAGTCTCCTGGCTTTACTGGGTGGAGAGGTGCTCAGCAGCTTCTGTCACTAGCTCTGAATGGCCTGTCTCCTGGACAAAGAAGCTTTCACGGACTACTCTGCAGGGAGGTGACATTGGACCAGAGCTGACTCCACCTGGGGGAAAGAGTAATTCTCTGGTTTCTTTATAGGTGCCTGTGTAGAAAGAGTCAGGGAGGGATTGGGTGACTTCTAGACCAATTAACTTTTCTTCTTTCCCATCCAAGGGAGTCCAGAGAGGGAAGGGAAAGATCTAACAACTCTAGCCTTTGTGGTTGGCCTCGTGGATGGGGTGGGAGTCCTGGCAGCTCCACTTCTGACTGGAAGGGGTTCACTTGATCCTTTTCTTTCACCTGGAACCTTAGTTGAATAAAGGTCAAGTGACATATTTTAGTGCCTTACTTGAGAGCCATGTTTCCAAATCTAGTACCTTTGATAAAAGTGAGGAGGCTGTGGACAGCTCTCTCCCTCTGACCAGCACTTATCCTGGCAGCTGCCAACATCCTGGGCCATGAGAATAAGGGTGTCTACGTGCTGATGAGTGGGCTGGACCTGGAGCGGCTGGTGCTGGCCGGGGGGCCTCTTGGGTAAGTGTGAGAGGCTTGAGGGAAGCTGGGCTCTGTCGGCCTCCTCGGCAGGTGACCCACCATGAGCAGCAGCAGCCTTCCCCTTGCGGGGCCAAAGGGAGCTGCCTCTTGGCCCTGCTCTCTCCTGGGAGATGAAAGGAACCTCCTCTTCCCATGTTGAATTTCTTCCCACAGTGGGGAAATATCATTAAGTAACAGACAAAAGGCCTGAGGAGCAGGGTGGCTTACTCGGCTGTGAAACGACACCTGGGCTGTCACGCCCCTGCACCTCTGGCCAGTCAGTGCCGTAACTGTGGCAAGACTTTCTGAAGTTGCTTTTCTCCTCCCTGGGATTCTGGCCTTCCCACGCTAGCATTTTGCCACCACACCCGGTGGTGGGATGAGGAGGTGCCCACGGGGCCTTTCTCCTTTCTGACAGGCTCATGCAAGCGGTCCTGGACCACACCATTCCCTACCTGCACGTGAGGGAAGTCTTTGGCCAGAAGATCGGCCACTTCCAGGTGAGCCGAGTGCTTTTGCTGACATGTACTCTTCAACTGGGCTAAAGTTTTCTTTGAAAAGAGAGGAAGTGAGGTGGGCACCGTGGATGGTTACTGTCTCCTCTAGCAAATTGAGCTTGACTGCTTGGAATGCAGTCTTCCTCAGCATGCAGCCTGACTCTGGAAGTCATCAGGAAGTTCACCACATTGCCACCTCGATTCCTGTGTGAGGTGGATGAACTAGACATTGTAAGGTTGGAGAGCAAAGCGTGCAAGTTGTGGGGGCAGAAGGGAAAGAGGTTGCTATTTGTAGTTAGACCTTCTGGTCCGAAGAAGCTGCTGGAAGGTAATAAGCATTGGAGTAAATGGTGCCTTGGGAGCCATGCCTTTCGGAGGCAGTGATGGCCACTTCGGGGTGTCATGCGGGCTGTGGAACAGCCACTCTGTGGCCCTAACTCCCACACCTGCCCCCATCTCCATCATCCTGAGTAAATCCCATCTCCTCTCCATGCCCCTGCTTCCTCATCCTTGGCTGTCTTGTTGCCATTGCTGACCTGCTTTTGGTAACTGAGAGAGTGTTCCAGCATGTTGACCTGTGACATCCCTTTGTGCCCAGTTGATGCAGGGGAAGATGGCTGACATGTACACCCGCCTCATGGCGTGTCGGCAGTATGTCTACAATGTCGCCAAGGCCTGCGATGAGGGCCATTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGTAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCGCATGCCGGGCATGATGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAACAAAGATTGCACCATTGCACTCCAGCCTAGGTGACAGAGCGAGAGGCTGTCTCAAAAAAAAGCAATTTCCTCTCCACTTCTCCACTCCTCACTATGTGCTTATGCTAGGCCCAGCTGAGCTGGGACCTTCGGGCTCTTTCTGTCCCAGTTACAAGGAGGAAATGGAAAGCAAATGAGAAAACTGCTAGATGCCAGGAGTTGCTGCTGCCTTCGGCAACACCCCCCTCTCATCCTCCCCGCCTCATAGATGCTAGGAAATGGGAAAGGGAGATGTGGCTGGGCACAGTGGCTCACACCTGTAATTCCAACACTTTAGGAGACTGAGGCCAGTGAATCACCTGAGATCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAAAAAATTAGCCAAGTGTGGTGGCAGGAGCCTGTAATCCCAGCTATTTGGAAGGCTGAGGCTGGAGAATCTCTTGAACCCAGGAGGCGGAGGTTGCAGTGACCGGAGATCGCGCCATTGCACTCCAGCCTGAGTGACAAGAGTGAAACTCCGTCTCGGAAAAAAAAAAAAAAAAAAAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGCAGTGGTGCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTTGGATGCGGAGGTTGCAGAGAGCCAATATCATGCCACTGCACTCCAGCCTAGGCCACAGAGCATGACTC
Task1_train_20526
Consider a variant on Chromosome 15 in gene IVD (isovaleryl-CoA dehydrogenase). Determine its clinical classification and disease relevance.
Pathogenic; Isovaleryl-CoA dehydrogenase deficiency
CGAACTCCTGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCCAGGATTATAGGCCTGAGCCACCTTGCCTGGCCAGGGGCATGGATTTGATCAACAGTTAGGTTTGCTGTCTGCCTCAGCCATATACCACGCCTATCACTGACAGCCCAAAAAAGTGTACTTTAATTACAGGGAGCATCCAGGGAGGGGGAGCTGTGCAGCTCCTTCTTTGTTGACAGGAAAAAATTCAGCTAGCATTAAAGGCAGGTCAGTAGTGTCAACCTGTTTTCCTGCCCACACCTCCCAAGGCCATCCAGTCTCCTGGCTTTACTGGGTGGAGAGGTGCTCAGCAGCTTCTGTCACTAGCTCTGAATGGCCTGTCTCCTGGACAAAGAAGCTTTCACGGACTACTCTGCAGGGAGGTGACATTGGACCAGAGCTGACTCCACCTGGGGGAAAGAGTAATTCTCTGGTTTCTTTATAGGTGCCTGTGTAGAAAGAGTCAGGGAGGGATTGGGTGACTTCTAGACCAATTAACTTTTCTTCTTTCCCATCCAAGGGAGTCCAGAGAGGGAAGGGAAAGATCTAACAACTCTAGCCTTTGTGGTTGGCCTCGTGGATGGGGTGGGAGTCCTGGCAGCTCCACTTCTGACTGGAAGGGGTTCACTTGATCCTTTTCTTTCACCTGGAACCTTAGTTGAATAAAGGTCAAGTGACATATTTTAGTGCCTTACTTGAGAGCCATGTTTCCAAATCTAGTACCTTTGATAAAAGTGAGGAGGCTGTGGACAGCTCTCTCCCTCTGACCAGCACTTATCCTGGCAGCTGCCAACATCCTGGGCCATGAGAATAAGGGTGTCTACGTGCTGATGAGTGGGCTGGACCTGGAGCGGCTGGTGCTGGCCGGGGGGCCTCTTGGGTAAGTGTGAGAGGCTTGAGGGAAGCTGGGCTCTGTCGGCCTCCTCGGCAGGTGACCCACCATGAGCAGCAGCAGCCTTCCCCTTGCGGGGCCAAAGGGAGCTGCCTCTTGGCCCTGCTCTCTCCTGGGAGATGAAAGGAACCTCCTCTTCCCATGTTGAATTTCTTCCCACAGTGGGGAAATATCATTAAGTAACAGACAAAAGGCCTGAGGAGCAGGGTGGCTTACTCGGCTGTGAAACGACACCTGGGCTGTCACGCCCCTGCACCTCTGGCCAGTCAGTGCCGTAACTGTGGCAAGACTTTCTGAAGTTGCTTTTCTCCTCCCTGGGATTCTGGCCTTCCCACGCTAGCATTTTGCCACCACACCCGGTGGTGGGATGAGGAGGTGCCCACGGGGCCTTTCTCCTTTCTGACAGGCTCATGCAAGCGGTCCTGGACCACACCATTCCCTACCTGCACGTGAGGGAAGCCTTTGGCCAGAAGATCGGCCACTTCCAGGTGAGCCGAGTGCTTTTGCTGACATGTACTCTTCAACTGGGCTAAAGTTTTCTTTGAAAAGAGAGGAAGTGAGGTGGGCACCGTGGATGGTTACTGTCTCCTCTAGCAAATTGAGCTTGACTGCTTGGAATGCAGTCTTCCTCAGCATGCAGCCTGACTCTGGAAGTCATCAGGAAGTTCACCACATTGCCACCTCGATTCCTGTGTGAGGTGGATGAACTAGACATTGTAAGGTTGGAGAGCAAAGCGTGCAAGTTGTGGGGGCAGAAGGGAAAGAGGTTGCTATTTGTAGTTAGACCTTCTGGTCCGAAGAAGCTGCTGGAAGGTAATAAGCATTGGAGTAAATGGTGCCTTGGGAGCCATGCCTTTCGGAGGCAGTGATGGCCACTTCGGGGTGTCATGCGGGCTGTGGAACAGCCACTCTGTGGCCCTAACTCCCACACCTGCCCCCATCTCCATCATCCTGAGTAAATCCCATCTCCTCTCCATGCCCCTGCTTCCTCATCCTTGGCTGTCTTGTTGCCATTGCTGACCTGCTTTTGGTAACTGAGAGAGTGTTCCAGCATGTTGACCTGTGACATCCCTTTGTGCCCAGTTGATGCAGGGGAAGATGGCTGACATGTACACCCGCCTCATGGCGTGTCGGCAGTATGTCTACAATGTCGCCAAGGCCTGCGATGAGGGCCATTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGTAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCGCATGCCGGGCATGATGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAACAAAGATTGCACCATTGCACTCCAGCCTAGGTGACAGAGCGAGAGGCTGTCTCAAAAAAAAGCAATTTCCTCTCCACTTCTCCACTCCTCACTATGTGCTTATGCTAGGCCCAGCTGAGCTGGGACCTTCGGGCTCTTTCTGTCCCAGTTACAAGGAGGAAATGGAAAGCAAATGAGAAAACTGCTAGATGCCAGGAGTTGCTGCTGCCTTCGGCAACACCCCCCTCTCATCCTCCCCGCCTCATAGATGCTAGGAAATGGGAAAGGGAGATGTGGCTGGGCACAGTGGCTCACACCTGTAATTCCAACACTTTAGGAGACTGAGGCCAGTGAATCACCTGAGATCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAAAAAATTAGCCAAGTGTGGTGGCAGGAGCCTGTAATCCCAGCTATTTGGAAGGCTGAGGCTGGAGAATCTCTTGAACCCAGGAGGCGGAGGTTGCAGTGACCGGAGATCGCGCCATTGCACTCCAGCCTGAGTGACAAGAGTGAAACTCCGTCTCGGAAAAAAAAAAAAAAAAAAAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGCAGTGGTGCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTTGGATGCGGAGGTTGCAGAGAGCCAATATCATGCCACTGCACTCCAGCCTAGGCCACAGAGCATGACTCCAAAAAAAAAAAAAAAAAAGCTAAATGGAAATTTCTAGAAATAGTTCATAAGTTTCAAATCCACACCATCCTGAATAGCTTGAAGTGTTGTGCCATGCTGCTCTGTCATGTTTGGTACGTGAATCGTCCCTTTGTGCAGCCTATCTATGCTATGTGGGCTACCTGCCCGTTAGTAGTCACCTAGGGTATCCAATCAGCTGTCCTGATATCAGAGTGCCTGTGTTCAAGTAACTCTTATTTTGCTCAGTGGCCCCAGATTGCAAGAGTAGTGATGCTGGCATGTCATAATAGTTCTATTTTAGTATTTGTTATTATTGTTGATCTGTTACTATGCCTAGCTCATAAATTAAACTTTCTCATAAGTATGTATGTATAGGGAAAAAAACAACATATATATGGGGTTCGGTACTATCTACGGTTTCAGGCATCCACTGGGGTCTTGGAATGTATCCTCCAAGGATAAGGAAGGACTAGTGTATTCCCCACACCCCTCCCTCTTGCTACCTTTTGCTGCTTTTCTTTAATCACCCTCTCCTCCTGTGGCCTGTTTCTATATACTTGGCATTCTGTTTGCTTTCTTTGTTTTGTCAATCACTTCCTTTCTTCTCTGCCCAAACCCTGGTTGCAGGTGGCAATGGCTACATCAATGACTTTCCCATGGGCCGCTTTCTT
CGAACTCCTGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCCAGGATTATAGGCCTGAGCCACCTTGCCTGGCCAGGGGCATGGATTTGATCAACAGTTAGGTTTGCTGTCTGCCTCAGCCATATACCACGCCTATCACTGACAGCCCAAAAAAGTGTACTTTAATTACAGGGAGCATCCAGGGAGGGGGAGCTGTGCAGCTCCTTCTTTGTTGACAGGAAAAAATTCAGCTAGCATTAAAGGCAGGTCAGTAGTGTCAACCTGTTTTCCTGCCCACACCTCCCAAGGCCATCCAGTCTCCTGGCTTTACTGGGTGGAGAGGTGCTCAGCAGCTTCTGTCACTAGCTCTGAATGGCCTGTCTCCTGGACAAAGAAGCTTTCACGGACTACTCTGCAGGGAGGTGACATTGGACCAGAGCTGACTCCACCTGGGGGAAAGAGTAATTCTCTGGTTTCTTTATAGGTGCCTGTGTAGAAAGAGTCAGGGAGGGATTGGGTGACTTCTAGACCAATTAACTTTTCTTCTTTCCCATCCAAGGGAGTCCAGAGAGGGAAGGGAAAGATCTAACAACTCTAGCCTTTGTGGTTGGCCTCGTGGATGGGGTGGGAGTCCTGGCAGCTCCACTTCTGACTGGAAGGGGTTCACTTGATCCTTTTCTTTCACCTGGAACCTTAGTTGAATAAAGGTCAAGTGACATATTTTAGTGCCTTACTTGAGAGCCATGTTTCCAAATCTAGTACCTTTGATAAAAGTGAGGAGGCTGTGGACAGCTCTCTCCCTCTGACCAGCACTTATCCTGGCAGCTGCCAACATCCTGGGCCATGAGAATAAGGGTGTCTACGTGCTGATGAGTGGGCTGGACCTGGAGCGGCTGGTGCTGGCCGGGGGGCCTCTTGGGTAAGTGTGAGAGGCTTGAGGGAAGCTGGGCTCTGTCGGCCTCCTCGGCAGGTGACCCACCATGAGCAGCAGCAGCCTTCCCCTTGCGGGGCCAAAGGGAGCTGCCTCTTGGCCCTGCTCTCTCCTGGGAGATGAAAGGAACCTCCTCTTCCCATGTTGAATTTCTTCCCACAGTGGGGAAATATCATTAAGTAACAGACAAAAGGCCTGAGGAGCAGGGTGGCTTACTCGGCTGTGAAACGACACCTGGGCTGTCACGCCCCTGCACCTCTGGCCAGTCAGTGCCGTAACTGTGGCAAGACTTTCTGAAGTTGCTTTTCTCCTCCCTGGGATTCTGGCCTTCCCACGCTAGCATTTTGCCACCACACCCGGTGGTGGGATGAGGAGGTGCCCACGGGGCCTTTCTCCTTTCTGACAGGCTCATGCAAGCGGTCCTGGACCACACCATTCCCTACCTGCACGTGAGGGAAGCCTTTGGCCAGAAGATCGGCCACTTCCAGGTGAGCCGAGTGCTTTTGCTGACATGTACTCTTCAACTGGGCTAAAGTTTTCTTTGAAAAGAGAGGAAGTGAGGTGGGCACCGTGGATGGTTACTGTCTCCTCTAGCAAATTGAGCTTGACTGCTTGGAATGCAGTCTTCCTCAGCATGCAGCCTGACTCTGGAAGTCATCAGGAAGTTCACCACATTGCCACCTCGATTCCTGTGTGAGGTGGATGAACTAGACATTGTAAGGTTGGAGAGCAAAGCGTGCAAGTTGTGGGGGCAGAAGGGAAAGAGGTTGCTATTTGTAGTTAGACCTTCTGGTCCGAAGAAGCTGCTGGAAGGTAATAAGCATTGGAGTAAATGGTGCCTTGGGAGCCATGCCTTTCGGAGGCAGTGATGGCCACTTCGGGGTGTCATGCGGGCTGTGGAACAGCCACTCTGTGGCCCTAACTCCCACACCTGCCCCCATCTCCATCATCCTGAGTAAATCCCATCTCCTCTCCATGCCCCTGCTTCCTCATCCTTGGCTGTCTTGTTGCCATTGCTGACCTGCTTTTGGTAACTGAGAGAGTGTTCCAGCATGTTGACCTGTGACATCCCTTTGTGCCCAGTTGATGCAGGGGAAGATGGCTGACATGTACACCCGCCTCATGGCGTGTGGGCAGTATGTCTACAATGTCGCCAAGGCCTGCGATGAGGGCCATTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGTAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCGCATGCCGGGCATGATGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAACAAAGATTGCACCATTGCACTCCAGCCTAGGTGACAGAGCGAGAGGCTGTCTCAAAAAAAAGCAATTTCCTCTCCACTTCTCCACTCCTCACTATGTGCTTATGCTAGGCCCAGCTGAGCTGGGACCTTCGGGCTCTTTCTGTCCCAGTTACAAGGAGGAAATGGAAAGCAAATGAGAAAACTGCTAGATGCCAGGAGTTGCTGCTGCCTTCGGCAACACCCCCCTCTCATCCTCCCCGCCTCATAGATGCTAGGAAATGGGAAAGGGAGATGTGGCTGGGCACAGTGGCTCACACCTGTAATTCCAACACTTTAGGAGACTGAGGCCAGTGAATCACCTGAGATCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAAAAAATTAGCCAAGTGTGGTGGCAGGAGCCTGTAATCCCAGCTATTTGGAAGGCTGAGGCTGGAGAATCTCTTGAACCCAGGAGGCGGAGGTTGCAGTGACCGGAGATCGCGCCATTGCACTCCAGCCTGAGTGACAAGAGTGAAACTCCGTCTCGGAAAAAAAAAAAAAAAAAAAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGCAGTGGTGCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTTGGATGCGGAGGTTGCAGAGAGCCAATATCATGCCACTGCACTCCAGCCTAGGCCACAGAGCATGACTCCAAAAAAAAAAAAAAAAAAGCTAAATGGAAATTTCTAGAAATAGTTCATAAGTTTCAAATCCACACCATCCTGAATAGCTTGAAGTGTTGTGCCATGCTGCTCTGTCATGTTTGGTACGTGAATCGTCCCTTTGTGCAGCCTATCTATGCTATGTGGGCTACCTGCCCGTTAGTAGTCACCTAGGGTATCCAATCAGCTGTCCTGATATCAGAGTGCCTGTGTTCAAGTAACTCTTATTTTGCTCAGTGGCCCCAGATTGCAAGAGTAGTGATGCTGGCATGTCATAATAGTTCTATTTTAGTATTTGTTATTATTGTTGATCTGTTACTATGCCTAGCTCATAAATTAAACTTTCTCATAAGTATGTATGTATAGGGAAAAAAACAACATATATATGGGGTTCGGTACTATCTACGGTTTCAGGCATCCACTGGGGTCTTGGAATGTATCCTCCAAGGATAAGGAAGGACTAGTGTATTCCCCACACCCCTCCCTCTTGCTACCTTTTGCTGCTTTTCTTTAATCACCCTCTCCTCCTGTGGCCTGTTTCTATATACTTGGCATTCTGTTTGCTTTCTTTGTTTTGTCAATCACTTCCTTTCTTCTCTGCCCAAACCCTGGTTGCAGGTGGCAATGGCTACATCAATGACTTTCCCATGGGCCGCTTTCTT
Task1_train_20527
The gene IVD (isovaleryl-CoA dehydrogenase) is located on Chromosome 15, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Isovaleryl-CoA dehydrogenase deficiency
ACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGTAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCGCATGCCGGGCATGATGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAACAAAGATTGCACCATTGCACTCCAGCCTAGGTGACAGAGCGAGAGGCTGTCTCAAAAAAAAGCAATTTCCTCTCCACTTCTCCACTCCTCACTATGTGCTTATGCTAGGCCCAGCTGAGCTGGGACCTTCGGGCTCTTTCTGTCCCAGTTACAAGGAGGAAATGGAAAGCAAATGAGAAAACTGCTAGATGCCAGGAGTTGCTGCTGCCTTCGGCAACACCCCCCTCTCATCCTCCCCGCCTCATAGATGCTAGGAAATGGGAAAGGGAGATGTGGCTGGGCACAGTGGCTCACACCTGTAATTCCAACACTTTAGGAGACTGAGGCCAGTGAATCACCTGAGATCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAAAAAATTAGCCAAGTGTGGTGGCAGGAGCCTGTAATCCCAGCTATTTGGAAGGCTGAGGCTGGAGAATCTCTTGAACCCAGGAGGCGGAGGTTGCAGTGACCGGAGATCGCGCCATTGCACTCCAGCCTGAGTGACAAGAGTGAAACTCCGTCTCGGAAAAAAAAAAAAAAAAAAAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGCAGTGGTGCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTTGGATGCGGAGGTTGCAGAGAGCCAATATCATGCCACTGCACTCCAGCCTAGGCCACAGAGCATGACTCCAAAAAAAAAAAAAAAAAAGCTAAATGGAAATTTCTAGAAATAGTTCATAAGTTTCAAATCCACACCATCCTGAATAGCTTGAAGTGTTGTGCCATGCTGCTCTGTCATGTTTGGTACGTGAATCGTCCCTTTGTGCAGCCTATCTATGCTATGTGGGCTACCTGCCCGTTAGTAGTCACCTAGGGTATCCAATCAGCTGTCCTGATATCAGAGTGCCTGTGTTCAAGTAACTCTTATTTTGCTCAGTGGCCCCAGATTGCAAGAGTAGTGATGCTGGCATGTCATAATAGTTCTATTTTAGTATTTGTTATTATTGTTGATCTGTTACTATGCCTAGCTCATAAATTAAACTTTCTCATAAGTATGTATGTATAGGGAAAAAAACAACATATATATGGGGTTCGGTACTATCTACGGTTTCAGGCATCCACTGGGGTCTTGGAATGTATCCTCCAAGGATAAGGAAGGACTAGTGTATTCCCCACACCCCTCCCTCTTGCTACCTTTTGCTGCTTTTCTTTAATCACCCTCTCCTCCTGTGGCCTGTTTCTATATACTTGGCATTCTGTTTGCTTTCTTTGTTTTGTCAATCACTTCCTTTCTTCTCTGCCCAAACCCTGGTTGCAGGTGGCAATGGCTACATCAATGACTTTCCCATGGGCCGCTTTCTTCGAGATGCCAAGCTGTATGAGATAGGGGCTGGGACCAGCGAGGTGAGGCGGCTGGTCATCGGCAGAGCCTTCAATGCAGACTTTCACTAGTCCTGAGACCCTTCGCCCCCTTTTCCTGCACCTAGTGGCCTTTCTTGGGAAGTAGAGATGTGGCGGCTTTCCCACCCTGCCCACAGCAGGCCCTCCTGCCCAGCTGCTCTTGTCAGCCCTCTGGCCTCTGGATGAGGTTGAGTTCTCCACAACAGCTCCCAAGCATCATGGGCCTCGCAGCCGGGCCTGTGCCACGGCTAGTGTTGTGTGATTTAAAATGGACTCAGCAGGAAGCATATTGTCTGGGGATTGTTGGGACAGGTTTTGGTGACTCTGTGCCCTTGCTCTCTAACTTCTGAGCCCACCTCCCAGGGTAGGCACCTGGGGGCATGCAGGTGCCCACCTCCCAGGGTAGGCACCTGGGGGCATGCAGGTACCCACCTCTTTCTCTTGGGTGAGGCTCTGGCAAGGAGATCTCTCTGCTCAAGCACAGCAGAATCATGGCCCCTCTCCATGAATTGGAACTTGGTACAGGTTAAGTATCCCTAATCCTGAAATCTGAAACACTTGTGGTTCCAAGCATTTTGGATAAGGCAAATTCAACTTTCAGTCTCTTTTCTGGGGGAAAAAAATAATAAACCTAGCCTAGCCAGGCGTGGTGGCTCATGCTTGTAATCCCAGCACTTCAGGAGGCTGAGATGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGTGGAAACCTCGCCTCAACTAAAAATAGAAAAAAATTAGTTGGGCATGGTGGTGGGCACCTGTAATCCCAGCTACTTCAGGAGGCTGAGGCAGGAGAATTACTTGAACCCAGGAGGCGGACGTTGCAGTGAGCCGAGCTTGTGCCATTGCACTCCAGCCTGGGCGACAAGAGCAAAACTCTTCAAAAAACAAAACAAAACAAAAAAACCCTGGCCCTTGTTTCTTCCAGTTTCTAGAGGTATCAGCTCCTAGCAGCTTATGAACACATATGCTTGCTTGGCCAGGCAAGGTGGTGTGTGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACTTGCAGTCAGGAGTTCAAGACCAGCCTGTCCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGGGTGGTGGTGCACGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAATGAGCCAATATGACACCGCTGCAGTCCAGCCTGGGCCATAGAGTGAGACTCTGTCTCAAAAAAGGAAAGAAAAATAGGCTGGGCACAGTGACTCATGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTAAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCAGGCTCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAGAATTGCTTGAACCCGGGAGGCAGAGTTTGCAGTGAGCCAAGATCACACCACTGCACTCCAGCTTGGACGACAGAGCGAGACTCTGTCTCAAAAAATAATAGGCCAGGCATGGTGGCTCAACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACAAGGTCAGGAGTTCGAGACCAGCCTGACGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGCACGCGCCTGTAATCCCAGTTACACAGAAGACTGAGGCAGGAGAATCGCTTGAACGCAGGAGGCAGAGGTTGCAGGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCTCAAAAAATAATAATAAAATAAATGAACACACATGCTGCTGAGTCCGCAGGGGGGGCAGAGCAGAGGACAGCGTGCTTTTGTGTACTGTTGGAAGACTGGCTCCTCCTGTACAGCACCTCTGAGCCCTTGTGCACCGCCCTGCCACGGGCACCATCCAGTCCTGGCCGT
ACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGTAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCGCATGCCGGGCATGATGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAACAAAGATTGCACCATTGCACTCCAGCCTAGGTGACAGAGCGAGAGGCTGTCTCAAAAAAAAGCAATTTCCTCTCCACTTCTCCACTCCTCACTATGTGCTTATGCTAGGCCCAGCTGAGCTGGGACCTTCGGGCTCTTTCTGTCCCAGTTACAAGGAGGAAATGGAAAGCAAATGAGAAAACTGCTAGATGCCAGGAGTTGCTGCTGCCTTCGGCAACACCCCCCTCTCATCCTCCCCGCCTCATAGATGCTAGGAAATGGGAAAGGGAGATGTGGCTGGGCACAGTGGCTCACACCTGTAATTCCAACACTTTAGGAGACTGAGGCCAGTGAATCACCTGAGATCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAAAAAATTAGCCAAGTGTGGTGGCAGGAGCCTGTAATCCCAGCTATTTGGAAGGCTGAGGCTGGAGAATCTCTTGAACCCAGGAGGCGGAGGTTGCAGTGACCGGAGATCGCGCCATTGCACTCCAGCCTGAGTGACAAGAGTGAAACTCCGTCTCGGAAAAAAAAAAAAAAAAAAAGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGCAGTGGTGCGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTTGGATGCGGAGGTTGCAGAGAGCCAATATCATGCCACTGCACTCCAGCCTAGGCCACAGAGCATGACTCCAAAAAAAAAAAAAAAAAAGCTAAATGGAAATTTCTAGAAATAGTTCATAAGTTTCAAATCCACACCATCCTGAATAGCTTGAAGTGTTGTGCCATGCTGCTCTGTCATGTTTGGTACGTGAATCGTCCCTTTGTGCAGCCTATCTATGCTATGTGGGCTACCTGCCCGTTAGTAGTCACCTAGGGTATCCAATCAGCTGTCCTGATATCAGAGTGCCTGTGTTCAAGTAACTCTTATTTTGCTCAGTGGCCCCAGATTGCAAGAGTAGTGATGCTGGCATGTCATAATAGTTCTATTTTAGTATTTGTTATTATTGTTGATCTGTTACTATGCCTAGCTCATAAATTAAACTTTCTCATAAGTATGTATGTATAGGGAAAAAAACAACATATATATGGGGTTCGGTACTATCTACGGTTTCAGGCATCCACTGGGGTCTTGGAATGTATCCTCCAAGGATAAGGAAGGACTAGTGTATTCCCCACACCCCTCCCTCTTGCTACCTTTTGCTGCTTTTCTTTAATCACCCTCTCCTCCTGTGGCCTGTTTCTATATACTTGGCATTCTGTTTGCTTTCTTTGTTTTGTCAATCACTTCCTTTCTTCTCTGCCCAAACCCTGGTTGCAGGTGGCAATGGCTACATCAATGACTTTCCCATGGGCCGCTTTCTTCGAGATGCCAAGCTGTATGAGATAGGGGCTGGGACCAGCGAGGTGAGGTGGCTGGTCATCGGCAGAGCCTTCAATGCAGACTTTCACTAGTCCTGAGACCCTTCGCCCCCTTTTCCTGCACCTAGTGGCCTTTCTTGGGAAGTAGAGATGTGGCGGCTTTCCCACCCTGCCCACAGCAGGCCCTCCTGCCCAGCTGCTCTTGTCAGCCCTCTGGCCTCTGGATGAGGTTGAGTTCTCCACAACAGCTCCCAAGCATCATGGGCCTCGCAGCCGGGCCTGTGCCACGGCTAGTGTTGTGTGATTTAAAATGGACTCAGCAGGAAGCATATTGTCTGGGGATTGTTGGGACAGGTTTTGGTGACTCTGTGCCCTTGCTCTCTAACTTCTGAGCCCACCTCCCAGGGTAGGCACCTGGGGGCATGCAGGTGCCCACCTCCCAGGGTAGGCACCTGGGGGCATGCAGGTACCCACCTCTTTCTCTTGGGTGAGGCTCTGGCAAGGAGATCTCTCTGCTCAAGCACAGCAGAATCATGGCCCCTCTCCATGAATTGGAACTTGGTACAGGTTAAGTATCCCTAATCCTGAAATCTGAAACACTTGTGGTTCCAAGCATTTTGGATAAGGCAAATTCAACTTTCAGTCTCTTTTCTGGGGGAAAAAAATAATAAACCTAGCCTAGCCAGGCGTGGTGGCTCATGCTTGTAATCCCAGCACTTCAGGAGGCTGAGATGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGTGGAAACCTCGCCTCAACTAAAAATAGAAAAAAATTAGTTGGGCATGGTGGTGGGCACCTGTAATCCCAGCTACTTCAGGAGGCTGAGGCAGGAGAATTACTTGAACCCAGGAGGCGGACGTTGCAGTGAGCCGAGCTTGTGCCATTGCACTCCAGCCTGGGCGACAAGAGCAAAACTCTTCAAAAAACAAAACAAAACAAAAAAACCCTGGCCCTTGTTTCTTCCAGTTTCTAGAGGTATCAGCTCCTAGCAGCTTATGAACACATATGCTTGCTTGGCCAGGCAAGGTGGTGTGTGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACTTGCAGTCAGGAGTTCAAGACCAGCCTGTCCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGGGTGGTGGTGCACGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAATGAGCCAATATGACACCGCTGCAGTCCAGCCTGGGCCATAGAGTGAGACTCTGTCTCAAAAAAGGAAAGAAAAATAGGCTGGGCACAGTGACTCATGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTAAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCAGGCTCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAGAATTGCTTGAACCCGGGAGGCAGAGTTTGCAGTGAGCCAAGATCACACCACTGCACTCCAGCTTGGACGACAGAGCGAGACTCTGTCTCAAAAAATAATAGGCCAGGCATGGTGGCTCAACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACAAGGTCAGGAGTTCGAGACCAGCCTGACGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGCACGCGCCTGTAATCCCAGTTACACAGAAGACTGAGGCAGGAGAATCGCTTGAACGCAGGAGGCAGAGGTTGCAGGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCTCAAAAAATAATAATAAAATAAATGAACACACATGCTGCTGAGTCCGCAGGGGGGGCAGAGCAGAGGACAGCGTGCTTTTGTGTACTGTTGGAAGACTGGCTCCTCCTGTACAGCACCTCTGAGCCCTTGTGCACCGCCCTGCCACGGGCACCATCCAGTCCTGGCCGT
Task1_train_20528
With a mutation on Chromosome 15 in gene CHST14 (carbohydrate sulfotransferase 14), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; Ehlers-Danlos syndrome, musculocontractural type 1
GCCAGGGTGGCTGTAACAACTAAAGGAGATAATGAATATAAAACACTTAGTGGGCGCTGTCCTCAGTACACTTGGGCTCTAATCATATTCCTCTGCTGCTTCAGAGGCTTGCTGGCTCTCTGCAGGCAGCAAGCACATAGCTGGACCAAGTCTGGCTACTGAGCCAGGTTCCCAGTGGGAAATGGTGGTTGCTGACATCCAAAGCACTTCGGGTCTGCTGTCCGCCCAAGTGACCAGCCTGGTGCCATGGAGCACACATCTAGCTCCAGGCAAGGAGACTACGTGCTGTTTCCCTGCTGTTTTGTGCCCCCAGCTCCTCACCCTTCCAAATGTGTGTTGGCCACACCAGCAGCTGATGGACCAATGTGTCAGACCCTCCCCAGAGTGCCCAGTTATCCCACTGCCTCATGAGGAGAAGGCAGAGGAGGGGAGACTCCATTTCCAGACATTTCAGCATTACCCAGTGGACAAGCACTGTAGTCAGTCCCCAGGTATTGCTAAACACAAGGGTCACCATGGAGACTGGTCAGTGTCTGACAGTTCTGCTTCTCCTTCCTGGAGTGGCCACGACCTGCAGGACGGAGGGAGTTAAGGGTGGCAAGGGGGAGCACACCGAGGGCTCCGCTTCCAGCTGGAAAGACCAGCCTCCGGCACGTCTGGACTCGGAGAGAGCGCTGCCCGCCTCCCTGCCTCCAGACCCGTTGCTGGAGGAAGGGCTAGGACAGGCCTGAGTTTGTGGCGAATCCCCCTTGTCCACTTCCCTGAGGACACACGCTGCAGGAGAGCAGCCTCGAGTCTTTTCTGCCTTCGAGGTCTCAGGAGCTTTTGTCCCCAAGCCCAGAGGACAGGGGTGGCCCTGACTCAGGCGCCCTCTTCCGGGTAGGGGTCCGCGTGCGCCCTCCCAAGCCCGCGCCCCGCAGGGGCGCCCGCCCCTCTCCCCGCCCCCGGCGTGGGCCCGCCCCCGCGCCTGTGTCACTGCGAGGCCGGGGGTGGAGAGCGGCCGGGCGGGACATCCGGCCCGGGTCCCTCGCCGCGCCCGCCGCCCGCCGCCCGCTTCGGCGCCGCAGCCCGGGAGCCGGCCACCCCTACACGCGCCAGGGCTGTCCCCTGCCCTCCCCTCCCCAACTACCCCCGGTCCCAGACCCTCCTCCCGCCCCCAGCCCGAGCCCGCCTTCCAGGCCGCCCTCGGATCGGCCGGGCCCGCGCAGGCCCCCACCCCTTGAGCACCATGTTCCCCCGCCCGCTGACCCCGCTGGCGGCCCCAAATGGCGCCGAGCCCCTGGGCCGGGCGCTGAGGCGGGCCCCTCTGGGCAGGGCCCGGGCGGGGCTGGGTGGGCCGCCCCTGCTGCTGCCGTCCATGCTGATGTTTGCGGTGATCGTGGCCTCCAGCGGGCTGCTGCTCATGATCGAGCGGGGCATCCTGGCCGAGATGAAGCCCCTGCCCCTGCACCCGCCCGGCCGCGAGGGCACAGCCTGGCGCGGGAAAGCCCCCAAGCCTGGGGGCCTGTCCCTCAGGGCTGGGGACGCGGACTTGCAAGTGCGGCAGGACGTCCGGAACAGGACCCTGCGGGCGGTGTGCGGACAGCCAGGCATGCCCCGGGACCCCTGGGACTTGCCGGTGGGGCAGCGGCGCACCCTGCTGCGCCACATCCTCGTAAGTGACCGTTACCGCTTCCTCTACTGCTACGTCCCCAAGGTGGCCTGCTCTAACTGGAAGCGGGTGATGAAGGTGCTGGCAGGCGTCCTGGACAGCGTGGACGTCCGCCTCAAGATGGACCACCGCAGTGACCTGGTGTTCCTGGCCGACCTGCGGCCTGAGGAGATTCGCTACCGCCTGCAGCACTACTTTAAGTTCCTGTTTGTGCGGGAGCCCTTGGAACGCCTCCTCTCTGCCTACCGCAACAAGTTTGGCGAGATCCGAGAGTACCAGCAACGCTATGGGGCTGAGATAGTGAGGCGGTACAGGGCTGGAGCGGGGCCCAGCCCTGCAGGCGACGATGTCACATTCCCCGAGTTCCTGAGATACCTGGTGGATGAGGACCCTGAGCGCATGAATGAGCATTGGATGCCCGTGTACCACCTGTGCCAGCCTTGTGCCGTGCACTATGACTTTGTGGGCTCCTATGAGAGGCTGGAGGCTGATGCAAATCAGGTGCTGGAGTGGGTACGGGCACCACCTCACGTCCGATTTCCAGCTCGCCAGGCCTGGTACCGGCCAGCCAGCCCCGAAAGCCTGCATTACCACTTGTGCAGTGCCCCCCGGGCCCTGCTGCAGGATGTGCTGCCTAAGTATATCCTGGACTTCTCCCTCTTTGCCTACCCACTGCCTAATGTCACCAAGGAGGCGTGTCAGCAGTGACCATGGGTGTGGGGCCAGCAGCTGGTGGGGACTGGTTTCAACGCCAGCTTTCTGTGCTTCTGCCTGTCATTCGGAGAAACTCTGGCTCTGGGGCTTGGGGCTTCTCAGGATCCTGGATGGCAGAGACTGCCCTCAGAAGTTCCTTGTCCAGGGTGGGCACCCACAGTGACTCAGAGGACAGGGCTAGGCAGGAGACCTGCTGCTCCTCATTGGGGGGATCTCTTGGGGGGCAGACACCAGTTTGCCAATGAAGCAACACATCTGATCTAAAGACTGGCTCCAGACCCCGGGCTGCCAGGATTATGCAGTCCACTTGGTCTACCTTAATTTAACCTGTGGCCAAACTCAGAGATGGTACCAGCCAGGGGCAAGCATGACCAGAGCCAGGGACCCTGTGGCTCTGATCCCCCATTTATCCACCCCATGTGCCTCAGGACTAGAGTGAGCAATCATACCTTATAAATGACTTTTGTGCCTTTCTGCTCCAGTCTCAAAATTTCCTACACCTGCCAGTTCTTTACATTTTTCCAAGGAAAGGAAAACGGAAGCAGGGTTCTTGCCTGGTAGCTCCAGGACCCAGCTCTGCAGGCACCCAAAGACCCTCTGTGCCCAGCCTCTTCCTTGAGTTCTCGGAACCTCCTCCCTAATTCTCCCTTCCTTCCCCACAAGGCCTTTGAGGTTGTGACTGTGGCTGGTATATCTGGCTGCCATTTTTCTGATGCATTTATTTAAAATTTGTACTTTTTGATAGAACCCTTGTAAGGGCTTTGTTTTCCTAATAGCTGACTTTTTAATAAAGCAGTTTTATATATAAGGCGAGCATTTCTGTGATTTCCCTTGGAGCTCCTGTGGGCCCAGCAGATCTCCTCGATGTCTGTCTTCCCATGTCAGGGGAGGCAGCCTGTAGATAGAGAAAGTAAGGTATAACTTGGTTGGGCTGGTCCAATGGGCCGTTGCCATTCCATGGAGACTTTGGGGGCTTTCTAATAGGCTATACCAGATCACAGACTCAGATCCTGGGATGTCACCAAAGGGCAAGCCCAGTTAGGAATGGCCTCACGTCCAGAGCATACCTACATGTATTATTCCCTAAAAAAGTAGGTGGGTAGGAGATACGGGATCCTCCTCTTATTCAATAAGAGTTGAATGAGAAGTTCCCCCAGAGCATTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTGAGATGAAGTCTCGATCTGTCACCCAGGCTGCAGTGCAGTAGCACCATCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCTAGCGATTGCCTCAGCCTCCCAAGTAGCTGGGATGATTACAGGCACGCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTTTGAACTCCTAACCTCAGGTGATCTGCCCACCTCGGCCCCTCCAAAGTGCTAGGATTACAGGCGTGAGCTACCACGCCTGGCCCCGGACCATTTTCAAATGAAAAAGAAAATTTTTGTGTGAGCAAGGAGATTTTTTTCTGGCACTACAAGGAAGGCAGGCAAGGAGGTTGAGTGAGGGTCAGGCTCTTGTTGACTTAGGTCCAGAGAAAGTTGTGGAAGGAATACAGTTGGAGCAGCAGAGGACAGACTTCAGTATGGCCCATTGCCCCCACTGCTCTCCAGGGATCCCAGGCCCATCAGGAGTTGCTGGGCCCAAGGGAGAGTTGCAAGGCCAGAGC
GCCAGGGTGGCTGTAACAACTAAAGGAGATAATGAATATAAAACACTTAGTGGGCGCTGTCCTCAGTACACTTGGGCTCTAATCATATTCCTCTGCTGCTTCAGAGGCTTGCTGGCTCTCTGCAGGCAGCAAGCACATAGCTGGACCAAGTCTGGCTACTGAGCCAGGTTCCCAGTGGGAAATGGTGGTTGCTGACATCCAAAGCACTTCGGGTCTGCTGTCCGCCCAAGTGACCAGCCTGGTGCCATGGAGCACACATCTAGCTCCAGGCAAGGAGACTACGTGCTGTTTCCCTGCTGTTTTGTGCCCCCAGCTCCTCACCCTTCCAAATGTGTGTTGGCCACACCAGCAGCTGATGGACCAATGTGTCAGACCCTCCCCAGAGTGCCCAGTTATCCCACTGCCTCATGAGGAGAAGGCAGAGGAGGGGAGACTCCATTTCCAGACATTTCAGCATTACCCAGTGGACAAGCACTGTAGTCAGTCCCCAGGTATTGCTAAACACAAGGGTCACCATGGAGACTGGTCAGTGTCTGACAGTTCTGCTTCTCCTTCCTGGAGTGGCCACGACCTGCAGGACGGAGGGAGTTAAGGGTGGCAAGGGGGAGCACACCGAGGGCTCCGCTTCCAGCTGGAAAGACCAGCCTCCGGCACGTCTGGACTCGGAGAGAGCGCTGCCCGCCTCCCTGCCTCCAGACCCGTTGCTGGAGGAAGGGCTAGGACAGGCCTGAGTTTGTGGCGAATCCCCCTTGTCCACTTCCCTGAGGACACACGCTGCAGGAGAGCAGCCTCGAGTCTTTTCTGCCTTCGAGGTCTCAGGAGCTTTTGTCCCCAAGCCCAGAGGACAGGGGTGGCCCTGACTCAGGCGCCCTCTTCCGGGTAGGGGTCCGCGTGCGCCCTCCCAAGCCCGCGCCCCGCAGGGGCGCCCGCCCCTCTCCCCGCCCCCGGCGTGGGCCCGCCCCCGCGCCTGTGTCACTGCGAGGCCGGGGGTGGAGAGCGGCCGGGCGGGACATCCGGCCCGGGTCCCTCGCCGCGCCCGCCGCCCGCCGCCCGCTTCGGCGCCGCAGCCCGGGAGCCGGCCACCCCTACACGCGCCAGGGCTGTCCCCTGCCCTCCCCTCCCCAACTACCCCCGGTCCCAGACCCTCCTCCCGCCCCCAGCCCGAGCCCGCCTTCCAGGCCGCCCTCGGATCGGCCGGGCCCGCGCAGGCCCCCACCCCTTGAGCACCATGTTCCCCCGCCCGCTGACCCCGCTGGCGGCCCCAAATGGCGCCGAGCCCCTGGGCCGGGCGCTGAGGCGGGCCCCTCTGGGCAGGGCCCGGGCGGGGCTGGGTGGGCCGCCCCTGCTGCTGCCGTCCATGCTGATGTTTGCGGTGATCGTGGCCTCCAGCGGGCTGCTGCTCATGATCGAGCGGGGCATCCTGGCCGAGATGAAGCCCCTGCCCCTGCACCCGCCCGGCCGCGAGGGCACAGCCTGGCGCGGGAAAGCCCCCAAGCCTGGGGGCCTGTCCCTCAGGGCTGGGGACGCGGACTTGCAAGTGCGGCAGGACGTCCGGAACAGGACCCTGCGGGCGGTGTGCGGACAGCCAGGCATGCCCCGGGACCCCTGGGACTTGCCGGTGGGGCAGCGGCGCACCCTGCTGCGCCACATCCTCGTAAGTGACCGTTACCGCTTCCTCTACTGCTACGTCCCCAAGGTGGCCTGCTCTAACTGGAAGCGGGTGATGAAGGTGCTGGCAGGCGTCCTGGACAGCGTGGACGTCCGCCTCAAGATGGACCACCGCAGTGACCTGGTGTTCCTGGCCGACCTGCGGCCTGAGGAGATTCGCTACCGCCTGCAGCACTACTTTAAGTTCCTGTTTGTGCGGGAGCCCTTGGAACGCCTCCTCTCTGCCTACCGCAACAAGTTTGGCGAGATCCGAGAGTACCAGCAACGCTATGGGGCTGAGATAGTGAGGCGGTACAGGGCTGGAGCGGGGCCCAGCCCTGCAGGCGACGATGTCACATTCCCCGAGTTCCTGAGATACCTGGTGGATGAGGACCCTGAGCCCATGAATGAGCATTGGATGCCCGTGTACCACCTGTGCCAGCCTTGTGCCGTGCACTATGACTTTGTGGGCTCCTATGAGAGGCTGGAGGCTGATGCAAATCAGGTGCTGGAGTGGGTACGGGCACCACCTCACGTCCGATTTCCAGCTCGCCAGGCCTGGTACCGGCCAGCCAGCCCCGAAAGCCTGCATTACCACTTGTGCAGTGCCCCCCGGGCCCTGCTGCAGGATGTGCTGCCTAAGTATATCCTGGACTTCTCCCTCTTTGCCTACCCACTGCCTAATGTCACCAAGGAGGCGTGTCAGCAGTGACCATGGGTGTGGGGCCAGCAGCTGGTGGGGACTGGTTTCAACGCCAGCTTTCTGTGCTTCTGCCTGTCATTCGGAGAAACTCTGGCTCTGGGGCTTGGGGCTTCTCAGGATCCTGGATGGCAGAGACTGCCCTCAGAAGTTCCTTGTCCAGGGTGGGCACCCACAGTGACTCAGAGGACAGGGCTAGGCAGGAGACCTGCTGCTCCTCATTGGGGGGATCTCTTGGGGGGCAGACACCAGTTTGCCAATGAAGCAACACATCTGATCTAAAGACTGGCTCCAGACCCCGGGCTGCCAGGATTATGCAGTCCACTTGGTCTACCTTAATTTAACCTGTGGCCAAACTCAGAGATGGTACCAGCCAGGGGCAAGCATGACCAGAGCCAGGGACCCTGTGGCTCTGATCCCCCATTTATCCACCCCATGTGCCTCAGGACTAGAGTGAGCAATCATACCTTATAAATGACTTTTGTGCCTTTCTGCTCCAGTCTCAAAATTTCCTACACCTGCCAGTTCTTTACATTTTTCCAAGGAAAGGAAAACGGAAGCAGGGTTCTTGCCTGGTAGCTCCAGGACCCAGCTCTGCAGGCACCCAAAGACCCTCTGTGCCCAGCCTCTTCCTTGAGTTCTCGGAACCTCCTCCCTAATTCTCCCTTCCTTCCCCACAAGGCCTTTGAGGTTGTGACTGTGGCTGGTATATCTGGCTGCCATTTTTCTGATGCATTTATTTAAAATTTGTACTTTTTGATAGAACCCTTGTAAGGGCTTTGTTTTCCTAATAGCTGACTTTTTAATAAAGCAGTTTTATATATAAGGCGAGCATTTCTGTGATTTCCCTTGGAGCTCCTGTGGGCCCAGCAGATCTCCTCGATGTCTGTCTTCCCATGTCAGGGGAGGCAGCCTGTAGATAGAGAAAGTAAGGTATAACTTGGTTGGGCTGGTCCAATGGGCCGTTGCCATTCCATGGAGACTTTGGGGGCTTTCTAATAGGCTATACCAGATCACAGACTCAGATCCTGGGATGTCACCAAAGGGCAAGCCCAGTTAGGAATGGCCTCACGTCCAGAGCATACCTACATGTATTATTCCCTAAAAAAGTAGGTGGGTAGGAGATACGGGATCCTCCTCTTATTCAATAAGAGTTGAATGAGAAGTTCCCCCAGAGCATTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTGAGATGAAGTCTCGATCTGTCACCCAGGCTGCAGTGCAGTAGCACCATCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCTAGCGATTGCCTCAGCCTCCCAAGTAGCTGGGATGATTACAGGCACGCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTTTGAACTCCTAACCTCAGGTGATCTGCCCACCTCGGCCCCTCCAAAGTGCTAGGATTACAGGCGTGAGCTACCACGCCTGGCCCCGGACCATTTTCAAATGAAAAAGAAAATTTTTGTGTGAGCAAGGAGATTTTTTTCTGGCACTACAAGGAAGGCAGGCAAGGAGGTTGAGTGAGGGTCAGGCTCTTGTTGACTTAGGTCCAGAGAAAGTTGTGGAAGGAATACAGTTGGAGCAGCAGAGGACAGACTTCAGTATGGCCCATTGCCCCCACTGCTCTCCAGGGATCCCAGGCCCATCAGGAGTTGCTGGGCCCAAGGGAGAGTTGCAAGGCCAGAGC
Task1_train_20529
Mutation context: Chromosome 15, Gene CHST14 (carbohydrate sulfotransferase 14). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Ehlers-Danlos syndrome, musculocontractural type
AAAGGAGATAATGAATATAAAACACTTAGTGGGCGCTGTCCTCAGTACACTTGGGCTCTAATCATATTCCTCTGCTGCTTCAGAGGCTTGCTGGCTCTCTGCAGGCAGCAAGCACATAGCTGGACCAAGTCTGGCTACTGAGCCAGGTTCCCAGTGGGAAATGGTGGTTGCTGACATCCAAAGCACTTCGGGTCTGCTGTCCGCCCAAGTGACCAGCCTGGTGCCATGGAGCACACATCTAGCTCCAGGCAAGGAGACTACGTGCTGTTTCCCTGCTGTTTTGTGCCCCCAGCTCCTCACCCTTCCAAATGTGTGTTGGCCACACCAGCAGCTGATGGACCAATGTGTCAGACCCTCCCCAGAGTGCCCAGTTATCCCACTGCCTCATGAGGAGAAGGCAGAGGAGGGGAGACTCCATTTCCAGACATTTCAGCATTACCCAGTGGACAAGCACTGTAGTCAGTCCCCAGGTATTGCTAAACACAAGGGTCACCATGGAGACTGGTCAGTGTCTGACAGTTCTGCTTCTCCTTCCTGGAGTGGCCACGACCTGCAGGACGGAGGGAGTTAAGGGTGGCAAGGGGGAGCACACCGAGGGCTCCGCTTCCAGCTGGAAAGACCAGCCTCCGGCACGTCTGGACTCGGAGAGAGCGCTGCCCGCCTCCCTGCCTCCAGACCCGTTGCTGGAGGAAGGGCTAGGACAGGCCTGAGTTTGTGGCGAATCCCCCTTGTCCACTTCCCTGAGGACACACGCTGCAGGAGAGCAGCCTCGAGTCTTTTCTGCCTTCGAGGTCTCAGGAGCTTTTGTCCCCAAGCCCAGAGGACAGGGGTGGCCCTGACTCAGGCGCCCTCTTCCGGGTAGGGGTCCGCGTGCGCCCTCCCAAGCCCGCGCCCCGCAGGGGCGCCCGCCCCTCTCCCCGCCCCCGGCGTGGGCCCGCCCCCGCGCCTGTGTCACTGCGAGGCCGGGGGTGGAGAGCGGCCGGGCGGGACATCCGGCCCGGGTCCCTCGCCGCGCCCGCCGCCCGCCGCCCGCTTCGGCGCCGCAGCCCGGGAGCCGGCCACCCCTACACGCGCCAGGGCTGTCCCCTGCCCTCCCCTCCCCAACTACCCCCGGTCCCAGACCCTCCTCCCGCCCCCAGCCCGAGCCCGCCTTCCAGGCCGCCCTCGGATCGGCCGGGCCCGCGCAGGCCCCCACCCCTTGAGCACCATGTTCCCCCGCCCGCTGACCCCGCTGGCGGCCCCAAATGGCGCCGAGCCCCTGGGCCGGGCGCTGAGGCGGGCCCCTCTGGGCAGGGCCCGGGCGGGGCTGGGTGGGCCGCCCCTGCTGCTGCCGTCCATGCTGATGTTTGCGGTGATCGTGGCCTCCAGCGGGCTGCTGCTCATGATCGAGCGGGGCATCCTGGCCGAGATGAAGCCCCTGCCCCTGCACCCGCCCGGCCGCGAGGGCACAGCCTGGCGCGGGAAAGCCCCCAAGCCTGGGGGCCTGTCCCTCAGGGCTGGGGACGCGGACTTGCAAGTGCGGCAGGACGTCCGGAACAGGACCCTGCGGGCGGTGTGCGGACAGCCAGGCATGCCCCGGGACCCCTGGGACTTGCCGGTGGGGCAGCGGCGCACCCTGCTGCGCCACATCCTCGTAAGTGACCGTTACCGCTTCCTCTACTGCTACGTCCCCAAGGTGGCCTGCTCTAACTGGAAGCGGGTGATGAAGGTGCTGGCAGGCGTCCTGGACAGCGTGGACGTCCGCCTCAAGATGGACCACCGCAGTGACCTGGTGTTCCTGGCCGACCTGCGGCCTGAGGAGATTCGCTACCGCCTGCAGCACTACTTTAAGTTCCTGTTTGTGCGGGAGCCCTTGGAACGCCTCCTCTCTGCCTACCGCAACAAGTTTGGCGAGATCCGAGAGTACCAGCAACGCTATGGGGCTGAGATAGTGAGGCGGTACAGGGCTGGAGCGGGGCCCAGCCCTGCAGGCGACGATGTCACATTCCCCGAGTTCCTGAGATACCTGGTGGATGAGGACCCTGAGCGCATGAATGAGCATTGGATGCCCGTGTACCACCTGTGCCAGCCTTGTGCCGTGCACTATGACTTTGTGGGCTCCTATGAGAGGCTGGAGGCTGATGCAAATCAGGTGCTGGAGTGGGTACGGGCACCACCTCACGTCCGATTTCCAGCTCGCCAGGCCTGGTACCGGCCAGCCAGCCCCGAAAGCCTGCATTACCACTTGTGCAGTGCCCCCCGGGCCCTGCTGCAGGATGTGCTGCCTAAGTATATCCTGGACTTCTCCCTCTTTGCCTACCCACTGCCTAATGTCACCAAGGAGGCGTGTCAGCAGTGACCATGGGTGTGGGGCCAGCAGCTGGTGGGGACTGGTTTCAACGCCAGCTTTCTGTGCTTCTGCCTGTCATTCGGAGAAACTCTGGCTCTGGGGCTTGGGGCTTCTCAGGATCCTGGATGGCAGAGACTGCCCTCAGAAGTTCCTTGTCCAGGGTGGGCACCCACAGTGACTCAGAGGACAGGGCTAGGCAGGAGACCTGCTGCTCCTCATTGGGGGGATCTCTTGGGGGGCAGACACCAGTTTGCCAATGAAGCAACACATCTGATCTAAAGACTGGCTCCAGACCCCGGGCTGCCAGGATTATGCAGTCCACTTGGTCTACCTTAATTTAACCTGTGGCCAAACTCAGAGATGGTACCAGCCAGGGGCAAGCATGACCAGAGCCAGGGACCCTGTGGCTCTGATCCCCCATTTATCCACCCCATGTGCCTCAGGACTAGAGTGAGCAATCATACCTTATAAATGACTTTTGTGCCTTTCTGCTCCAGTCTCAAAATTTCCTACACCTGCCAGTTCTTTACATTTTTCCAAGGAAAGGAAAACGGAAGCAGGGTTCTTGCCTGGTAGCTCCAGGACCCAGCTCTGCAGGCACCCAAAGACCCTCTGTGCCCAGCCTCTTCCTTGAGTTCTCGGAACCTCCTCCCTAATTCTCCCTTCCTTCCCCACAAGGCCTTTGAGGTTGTGACTGTGGCTGGTATATCTGGCTGCCATTTTTCTGATGCATTTATTTAAAATTTGTACTTTTTGATAGAACCCTTGTAAGGGCTTTGTTTTCCTAATAGCTGACTTTTTAATAAAGCAGTTTTATATATAAGGCGAGCATTTCTGTGATTTCCCTTGGAGCTCCTGTGGGCCCAGCAGATCTCCTCGATGTCTGTCTTCCCATGTCAGGGGAGGCAGCCTGTAGATAGAGAAAGTAAGGTATAACTTGGTTGGGCTGGTCCAATGGGCCGTTGCCATTCCATGGAGACTTTGGGGGCTTTCTAATAGGCTATACCAGATCACAGACTCAGATCCTGGGATGTCACCAAAGGGCAAGCCCAGTTAGGAATGGCCTCACGTCCAGAGCATACCTACATGTATTATTCCCTAAAAAAGTAGGTGGGTAGGAGATACGGGATCCTCCTCTTATTCAATAAGAGTTGAATGAGAAGTTCCCCCAGAGCATTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTGAGATGAAGTCTCGATCTGTCACCCAGGCTGCAGTGCAGTAGCACCATCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCTAGCGATTGCCTCAGCCTCCCAAGTAGCTGGGATGATTACAGGCACGCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTTTGAACTCCTAACCTCAGGTGATCTGCCCACCTCGGCCCCTCCAAAGTGCTAGGATTACAGGCGTGAGCTACCACGCCTGGCCCCGGACCATTTTCAAATGAAAAAGAAAATTTTTGTGTGAGCAAGGAGATTTTTTTCTGGCACTACAAGGAAGGCAGGCAAGGAGGTTGAGTGAGGGTCAGGCTCTTGTTGACTTAGGTCCAGAGAAAGTTGTGGAAGGAATACAGTTGGAGCAGCAGAGGACAGACTTCAGTATGGCCCATTGCCCCCACTGCTCTCCAGGGATCCCAGGCCCATCAGGAGTTGCTGGGCCCAAGGGAGAGTTGCAAGGCCAGAGCTGGCCCTTCTCTGTTAGCCCT
AAAGGAGATAATGAATATAAAACACTTAGTGGGCGCTGTCCTCAGTACACTTGGGCTCTAATCATATTCCTCTGCTGCTTCAGAGGCTTGCTGGCTCTCTGCAGGCAGCAAGCACATAGCTGGACCAAGTCTGGCTACTGAGCCAGGTTCCCAGTGGGAAATGGTGGTTGCTGACATCCAAAGCACTTCGGGTCTGCTGTCCGCCCAAGTGACCAGCCTGGTGCCATGGAGCACACATCTAGCTCCAGGCAAGGAGACTACGTGCTGTTTCCCTGCTGTTTTGTGCCCCCAGCTCCTCACCCTTCCAAATGTGTGTTGGCCACACCAGCAGCTGATGGACCAATGTGTCAGACCCTCCCCAGAGTGCCCAGTTATCCCACTGCCTCATGAGGAGAAGGCAGAGGAGGGGAGACTCCATTTCCAGACATTTCAGCATTACCCAGTGGACAAGCACTGTAGTCAGTCCCCAGGTATTGCTAAACACAAGGGTCACCATGGAGACTGGTCAGTGTCTGACAGTTCTGCTTCTCCTTCCTGGAGTGGCCACGACCTGCAGGACGGAGGGAGTTAAGGGTGGCAAGGGGGAGCACACCGAGGGCTCCGCTTCCAGCTGGAAAGACCAGCCTCCGGCACGTCTGGACTCGGAGAGAGCGCTGCCCGCCTCCCTGCCTCCAGACCCGTTGCTGGAGGAAGGGCTAGGACAGGCCTGAGTTTGTGGCGAATCCCCCTTGTCCACTTCCCTGAGGACACACGCTGCAGGAGAGCAGCCTCGAGTCTTTTCTGCCTTCGAGGTCTCAGGAGCTTTTGTCCCCAAGCCCAGAGGACAGGGGTGGCCCTGACTCAGGCGCCCTCTTCCGGGTAGGGGTCCGCGTGCGCCCTCCCAAGCCCGCGCCCCGCAGGGGCGCCCGCCCCTCTCCCCGCCCCCGGCGTGGGCCCGCCCCCGCGCCTGTGTCACTGCGAGGCCGGGGGTGGAGAGCGGCCGGGCGGGACATCCGGCCCGGGTCCCTCGCCGCGCCCGCCGCCCGCCGCCCGCTTCGGCGCCGCAGCCCGGGAGCCGGCCACCCCTACACGCGCCAGGGCTGTCCCCTGCCCTCCCCTCCCCAACTACCCCCGGTCCCAGACCCTCCTCCCGCCCCCAGCCCGAGCCCGCCTTCCAGGCCGCCCTCGGATCGGCCGGGCCCGCGCAGGCCCCCACCCCTTGAGCACCATGTTCCCCCGCCCGCTGACCCCGCTGGCGGCCCCAAATGGCGCCGAGCCCCTGGGCCGGGCGCTGAGGCGGGCCCCTCTGGGCAGGGCCCGGGCGGGGCTGGGTGGGCCGCCCCTGCTGCTGCCGTCCATGCTGATGTTTGCGGTGATCGTGGCCTCCAGCGGGCTGCTGCTCATGATCGAGCGGGGCATCCTGGCCGAGATGAAGCCCCTGCCCCTGCACCCGCCCGGCCGCGAGGGCACAGCCTGGCGCGGGAAAGCCCCCAAGCCTGGGGGCCTGTCCCTCAGGGCTGGGGACGCGGACTTGCAAGTGCGGCAGGACGTCCGGAACAGGACCCTGCGGGCGGTGTGCGGACAGCCAGGCATGCCCCGGGACCCCTGGGACTTGCCGGTGGGGCAGCGGCGCACCCTGCTGCGCCACATCCTCGTAAGTGACCGTTACCGCTTCCTCTACTGCTACGTCCCCAAGGTGGCCTGCTCTAACTGGAAGCGGGTGATGAAGGTGCTGGCAGGCGTCCTGGACAGCGTGGACGTCCGCCTCAAGATGGACCACCGCAGTGACCTGGTGTTCCTGGCCGACCTGCGGCCTGAGGAGATTCGCTACCGCCTGCAGCACTACTTTAAGTTCCTGTTTGTGCGGGAGCCCTTGGAACGCCTCCTCTCTGCCTACCGCAACAAGTTTGGCGAGATCCGAGAGTACCAGCAACGCTATGGGGCTGAGATAGTGAGGCGGTACAGGGCTGGAGCGGGGCCCAGCCCTGCAGGCGACGATGTCACATTCCCCGAGTTCCTGAGATACCTGGTGGATGAGGACCCTGAGCGCATGAATGAGCATTGGATGCTCGTGTACCACCTGTGCCAGCCTTGTGCCGTGCACTATGACTTTGTGGGCTCCTATGAGAGGCTGGAGGCTGATGCAAATCAGGTGCTGGAGTGGGTACGGGCACCACCTCACGTCCGATTTCCAGCTCGCCAGGCCTGGTACCGGCCAGCCAGCCCCGAAAGCCTGCATTACCACTTGTGCAGTGCCCCCCGGGCCCTGCTGCAGGATGTGCTGCCTAAGTATATCCTGGACTTCTCCCTCTTTGCCTACCCACTGCCTAATGTCACCAAGGAGGCGTGTCAGCAGTGACCATGGGTGTGGGGCCAGCAGCTGGTGGGGACTGGTTTCAACGCCAGCTTTCTGTGCTTCTGCCTGTCATTCGGAGAAACTCTGGCTCTGGGGCTTGGGGCTTCTCAGGATCCTGGATGGCAGAGACTGCCCTCAGAAGTTCCTTGTCCAGGGTGGGCACCCACAGTGACTCAGAGGACAGGGCTAGGCAGGAGACCTGCTGCTCCTCATTGGGGGGATCTCTTGGGGGGCAGACACCAGTTTGCCAATGAAGCAACACATCTGATCTAAAGACTGGCTCCAGACCCCGGGCTGCCAGGATTATGCAGTCCACTTGGTCTACCTTAATTTAACCTGTGGCCAAACTCAGAGATGGTACCAGCCAGGGGCAAGCATGACCAGAGCCAGGGACCCTGTGGCTCTGATCCCCCATTTATCCACCCCATGTGCCTCAGGACTAGAGTGAGCAATCATACCTTATAAATGACTTTTGTGCCTTTCTGCTCCAGTCTCAAAATTTCCTACACCTGCCAGTTCTTTACATTTTTCCAAGGAAAGGAAAACGGAAGCAGGGTTCTTGCCTGGTAGCTCCAGGACCCAGCTCTGCAGGCACCCAAAGACCCTCTGTGCCCAGCCTCTTCCTTGAGTTCTCGGAACCTCCTCCCTAATTCTCCCTTCCTTCCCCACAAGGCCTTTGAGGTTGTGACTGTGGCTGGTATATCTGGCTGCCATTTTTCTGATGCATTTATTTAAAATTTGTACTTTTTGATAGAACCCTTGTAAGGGCTTTGTTTTCCTAATAGCTGACTTTTTAATAAAGCAGTTTTATATATAAGGCGAGCATTTCTGTGATTTCCCTTGGAGCTCCTGTGGGCCCAGCAGATCTCCTCGATGTCTGTCTTCCCATGTCAGGGGAGGCAGCCTGTAGATAGAGAAAGTAAGGTATAACTTGGTTGGGCTGGTCCAATGGGCCGTTGCCATTCCATGGAGACTTTGGGGGCTTTCTAATAGGCTATACCAGATCACAGACTCAGATCCTGGGATGTCACCAAAGGGCAAGCCCAGTTAGGAATGGCCTCACGTCCAGAGCATACCTACATGTATTATTCCCTAAAAAAGTAGGTGGGTAGGAGATACGGGATCCTCCTCTTATTCAATAAGAGTTGAATGAGAAGTTCCCCCAGAGCATTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTGAGATGAAGTCTCGATCTGTCACCCAGGCTGCAGTGCAGTAGCACCATCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCTAGCGATTGCCTCAGCCTCCCAAGTAGCTGGGATGATTACAGGCACGCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTTTGAACTCCTAACCTCAGGTGATCTGCCCACCTCGGCCCCTCCAAAGTGCTAGGATTACAGGCGTGAGCTACCACGCCTGGCCCCGGACCATTTTCAAATGAAAAAGAAAATTTTTGTGTGAGCAAGGAGATTTTTTTCTGGCACTACAAGGAAGGCAGGCAAGGAGGTTGAGTGAGGGTCAGGCTCTTGTTGACTTAGGTCCAGAGAAAGTTGTGGAAGGAATACAGTTGGAGCAGCAGAGGACAGACTTCAGTATGGCCCATTGCCCCCACTGCTCTCCAGGGATCCCAGGCCCATCAGGAGTTGCTGGGCCCAAGGGAGAGTTGCAAGGCCAGAGCTGGCCCTTCTCTGTTAGCCCT
Task1_train_20530
A genetic alteration is present in CHST14 (carbohydrate sulfotransferase 14) on Chromosome 15. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Ehlers-Danlos syndrome, musculocontractural type 1
CTTAGTGGGCGCTGTCCTCAGTACACTTGGGCTCTAATCATATTCCTCTGCTGCTTCAGAGGCTTGCTGGCTCTCTGCAGGCAGCAAGCACATAGCTGGACCAAGTCTGGCTACTGAGCCAGGTTCCCAGTGGGAAATGGTGGTTGCTGACATCCAAAGCACTTCGGGTCTGCTGTCCGCCCAAGTGACCAGCCTGGTGCCATGGAGCACACATCTAGCTCCAGGCAAGGAGACTACGTGCTGTTTCCCTGCTGTTTTGTGCCCCCAGCTCCTCACCCTTCCAAATGTGTGTTGGCCACACCAGCAGCTGATGGACCAATGTGTCAGACCCTCCCCAGAGTGCCCAGTTATCCCACTGCCTCATGAGGAGAAGGCAGAGGAGGGGAGACTCCATTTCCAGACATTTCAGCATTACCCAGTGGACAAGCACTGTAGTCAGTCCCCAGGTATTGCTAAACACAAGGGTCACCATGGAGACTGGTCAGTGTCTGACAGTTCTGCTTCTCCTTCCTGGAGTGGCCACGACCTGCAGGACGGAGGGAGTTAAGGGTGGCAAGGGGGAGCACACCGAGGGCTCCGCTTCCAGCTGGAAAGACCAGCCTCCGGCACGTCTGGACTCGGAGAGAGCGCTGCCCGCCTCCCTGCCTCCAGACCCGTTGCTGGAGGAAGGGCTAGGACAGGCCTGAGTTTGTGGCGAATCCCCCTTGTCCACTTCCCTGAGGACACACGCTGCAGGAGAGCAGCCTCGAGTCTTTTCTGCCTTCGAGGTCTCAGGAGCTTTTGTCCCCAAGCCCAGAGGACAGGGGTGGCCCTGACTCAGGCGCCCTCTTCCGGGTAGGGGTCCGCGTGCGCCCTCCCAAGCCCGCGCCCCGCAGGGGCGCCCGCCCCTCTCCCCGCCCCCGGCGTGGGCCCGCCCCCGCGCCTGTGTCACTGCGAGGCCGGGGGTGGAGAGCGGCCGGGCGGGACATCCGGCCCGGGTCCCTCGCCGCGCCCGCCGCCCGCCGCCCGCTTCGGCGCCGCAGCCCGGGAGCCGGCCACCCCTACACGCGCCAGGGCTGTCCCCTGCCCTCCCCTCCCCAACTACCCCCGGTCCCAGACCCTCCTCCCGCCCCCAGCCCGAGCCCGCCTTCCAGGCCGCCCTCGGATCGGCCGGGCCCGCGCAGGCCCCCACCCCTTGAGCACCATGTTCCCCCGCCCGCTGACCCCGCTGGCGGCCCCAAATGGCGCCGAGCCCCTGGGCCGGGCGCTGAGGCGGGCCCCTCTGGGCAGGGCCCGGGCGGGGCTGGGTGGGCCGCCCCTGCTGCTGCCGTCCATGCTGATGTTTGCGGTGATCGTGGCCTCCAGCGGGCTGCTGCTCATGATCGAGCGGGGCATCCTGGCCGAGATGAAGCCCCTGCCCCTGCACCCGCCCGGCCGCGAGGGCACAGCCTGGCGCGGGAAAGCCCCCAAGCCTGGGGGCCTGTCCCTCAGGGCTGGGGACGCGGACTTGCAAGTGCGGCAGGACGTCCGGAACAGGACCCTGCGGGCGGTGTGCGGACAGCCAGGCATGCCCCGGGACCCCTGGGACTTGCCGGTGGGGCAGCGGCGCACCCTGCTGCGCCACATCCTCGTAAGTGACCGTTACCGCTTCCTCTACTGCTACGTCCCCAAGGTGGCCTGCTCTAACTGGAAGCGGGTGATGAAGGTGCTGGCAGGCGTCCTGGACAGCGTGGACGTCCGCCTCAAGATGGACCACCGCAGTGACCTGGTGTTCCTGGCCGACCTGCGGCCTGAGGAGATTCGCTACCGCCTGCAGCACTACTTTAAGTTCCTGTTTGTGCGGGAGCCCTTGGAACGCCTCCTCTCTGCCTACCGCAACAAGTTTGGCGAGATCCGAGAGTACCAGCAACGCTATGGGGCTGAGATAGTGAGGCGGTACAGGGCTGGAGCGGGGCCCAGCCCTGCAGGCGACGATGTCACATTCCCCGAGTTCCTGAGATACCTGGTGGATGAGGACCCTGAGCGCATGAATGAGCATTGGATGCCCGTGTACCACCTGTGCCAGCCTTGTGCCGTGCACTATGACTTTGTGGGCTCCTATGAGAGGCTGGAGGCTGATGCAAATCAGGTGCTGGAGTGGGTACGGGCACCACCTCACGTCCGATTTCCAGCTCGCCAGGCCTGGTACCGGCCAGCCAGCCCCGAAAGCCTGCATTACCACTTGTGCAGTGCCCCCCGGGCCCTGCTGCAGGATGTGCTGCCTAAGTATATCCTGGACTTCTCCCTCTTTGCCTACCCACTGCCTAATGTCACCAAGGAGGCGTGTCAGCAGTGACCATGGGTGTGGGGCCAGCAGCTGGTGGGGACTGGTTTCAACGCCAGCTTTCTGTGCTTCTGCCTGTCATTCGGAGAAACTCTGGCTCTGGGGCTTGGGGCTTCTCAGGATCCTGGATGGCAGAGACTGCCCTCAGAAGTTCCTTGTCCAGGGTGGGCACCCACAGTGACTCAGAGGACAGGGCTAGGCAGGAGACCTGCTGCTCCTCATTGGGGGGATCTCTTGGGGGGCAGACACCAGTTTGCCAATGAAGCAACACATCTGATCTAAAGACTGGCTCCAGACCCCGGGCTGCCAGGATTATGCAGTCCACTTGGTCTACCTTAATTTAACCTGTGGCCAAACTCAGAGATGGTACCAGCCAGGGGCAAGCATGACCAGAGCCAGGGACCCTGTGGCTCTGATCCCCCATTTATCCACCCCATGTGCCTCAGGACTAGAGTGAGCAATCATACCTTATAAATGACTTTTGTGCCTTTCTGCTCCAGTCTCAAAATTTCCTACACCTGCCAGTTCTTTACATTTTTCCAAGGAAAGGAAAACGGAAGCAGGGTTCTTGCCTGGTAGCTCCAGGACCCAGCTCTGCAGGCACCCAAAGACCCTCTGTGCCCAGCCTCTTCCTTGAGTTCTCGGAACCTCCTCCCTAATTCTCCCTTCCTTCCCCACAAGGCCTTTGAGGTTGTGACTGTGGCTGGTATATCTGGCTGCCATTTTTCTGATGCATTTATTTAAAATTTGTACTTTTTGATAGAACCCTTGTAAGGGCTTTGTTTTCCTAATAGCTGACTTTTTAATAAAGCAGTTTTATATATAAGGCGAGCATTTCTGTGATTTCCCTTGGAGCTCCTGTGGGCCCAGCAGATCTCCTCGATGTCTGTCTTCCCATGTCAGGGGAGGCAGCCTGTAGATAGAGAAAGTAAGGTATAACTTGGTTGGGCTGGTCCAATGGGCCGTTGCCATTCCATGGAGACTTTGGGGGCTTTCTAATAGGCTATACCAGATCACAGACTCAGATCCTGGGATGTCACCAAAGGGCAAGCCCAGTTAGGAATGGCCTCACGTCCAGAGCATACCTACATGTATTATTCCCTAAAAAAGTAGGTGGGTAGGAGATACGGGATCCTCCTCTTATTCAATAAGAGTTGAATGAGAAGTTCCCCCAGAGCATTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTGAGATGAAGTCTCGATCTGTCACCCAGGCTGCAGTGCAGTAGCACCATCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCTAGCGATTGCCTCAGCCTCCCAAGTAGCTGGGATGATTACAGGCACGCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTTTGAACTCCTAACCTCAGGTGATCTGCCCACCTCGGCCCCTCCAAAGTGCTAGGATTACAGGCGTGAGCTACCACGCCTGGCCCCGGACCATTTTCAAATGAAAAAGAAAATTTTTGTGTGAGCAAGGAGATTTTTTTCTGGCACTACAAGGAAGGCAGGCAAGGAGGTTGAGTGAGGGTCAGGCTCTTGTTGACTTAGGTCCAGAGAAAGTTGTGGAAGGAATACAGTTGGAGCAGCAGAGGACAGACTTCAGTATGGCCCATTGCCCCCACTGCTCTCCAGGGATCCCAGGCCCATCAGGAGTTGCTGGGCCCAAGGGAGAGTTGCAAGGCCAGAGCTGGCCCTTCTCTGTTAGCCCTATTTCACACACCCCCAGTGGGAAC
CTTAGTGGGCGCTGTCCTCAGTACACTTGGGCTCTAATCATATTCCTCTGCTGCTTCAGAGGCTTGCTGGCTCTCTGCAGGCAGCAAGCACATAGCTGGACCAAGTCTGGCTACTGAGCCAGGTTCCCAGTGGGAAATGGTGGTTGCTGACATCCAAAGCACTTCGGGTCTGCTGTCCGCCCAAGTGACCAGCCTGGTGCCATGGAGCACACATCTAGCTCCAGGCAAGGAGACTACGTGCTGTTTCCCTGCTGTTTTGTGCCCCCAGCTCCTCACCCTTCCAAATGTGTGTTGGCCACACCAGCAGCTGATGGACCAATGTGTCAGACCCTCCCCAGAGTGCCCAGTTATCCCACTGCCTCATGAGGAGAAGGCAGAGGAGGGGAGACTCCATTTCCAGACATTTCAGCATTACCCAGTGGACAAGCACTGTAGTCAGTCCCCAGGTATTGCTAAACACAAGGGTCACCATGGAGACTGGTCAGTGTCTGACAGTTCTGCTTCTCCTTCCTGGAGTGGCCACGACCTGCAGGACGGAGGGAGTTAAGGGTGGCAAGGGGGAGCACACCGAGGGCTCCGCTTCCAGCTGGAAAGACCAGCCTCCGGCACGTCTGGACTCGGAGAGAGCGCTGCCCGCCTCCCTGCCTCCAGACCCGTTGCTGGAGGAAGGGCTAGGACAGGCCTGAGTTTGTGGCGAATCCCCCTTGTCCACTTCCCTGAGGACACACGCTGCAGGAGAGCAGCCTCGAGTCTTTTCTGCCTTCGAGGTCTCAGGAGCTTTTGTCCCCAAGCCCAGAGGACAGGGGTGGCCCTGACTCAGGCGCCCTCTTCCGGGTAGGGGTCCGCGTGCGCCCTCCCAAGCCCGCGCCCCGCAGGGGCGCCCGCCCCTCTCCCCGCCCCCGGCGTGGGCCCGCCCCCGCGCCTGTGTCACTGCGAGGCCGGGGGTGGAGAGCGGCCGGGCGGGACATCCGGCCCGGGTCCCTCGCCGCGCCCGCCGCCCGCCGCCCGCTTCGGCGCCGCAGCCCGGGAGCCGGCCACCCCTACACGCGCCAGGGCTGTCCCCTGCCCTCCCCTCCCCAACTACCCCCGGTCCCAGACCCTCCTCCCGCCCCCAGCCCGAGCCCGCCTTCCAGGCCGCCCTCGGATCGGCCGGGCCCGCGCAGGCCCCCACCCCTTGAGCACCATGTTCCCCCGCCCGCTGACCCCGCTGGCGGCCCCAAATGGCGCCGAGCCCCTGGGCCGGGCGCTGAGGCGGGCCCCTCTGGGCAGGGCCCGGGCGGGGCTGGGTGGGCCGCCCCTGCTGCTGCCGTCCATGCTGATGTTTGCGGTGATCGTGGCCTCCAGCGGGCTGCTGCTCATGATCGAGCGGGGCATCCTGGCCGAGATGAAGCCCCTGCCCCTGCACCCGCCCGGCCGCGAGGGCACAGCCTGGCGCGGGAAAGCCCCCAAGCCTGGGGGCCTGTCCCTCAGGGCTGGGGACGCGGACTTGCAAGTGCGGCAGGACGTCCGGAACAGGACCCTGCGGGCGGTGTGCGGACAGCCAGGCATGCCCCGGGACCCCTGGGACTTGCCGGTGGGGCAGCGGCGCACCCTGCTGCGCCACATCCTCGTAAGTGACCGTTACCGCTTCCTCTACTGCTACGTCCCCAAGGTGGCCTGCTCTAACTGGAAGCGGGTGATGAAGGTGCTGGCAGGCGTCCTGGACAGCGTGGACGTCCGCCTCAAGATGGACCACCGCAGTGACCTGGTGTTCCTGGCCGACCTGCGGCCTGAGGAGATTCGCTACCGCCTGCAGCACTACTTTAAGTTCCTGTTTGTGCGGGAGCCCTTGGAACGCCTCCTCTCTGCCTACCGCAACAAGTTTGGCGAGATCCGAGAGTACCAGCAACGCTATGGGGCTGAGATAGTGAGGCGGTACAGGGCTGGAGCGGGGCCCAGCCCTGCAGGCGACGATGTCACATTCCCCGAGTTCCTGAGATACCTGGTGGATGAGGACCCTGAGCGCATGAATGAGCATTGGATGCCCGTGTACCACCTGTGCCAGCCTTCTGCCGTGCACTATGACTTTGTGGGCTCCTATGAGAGGCTGGAGGCTGATGCAAATCAGGTGCTGGAGTGGGTACGGGCACCACCTCACGTCCGATTTCCAGCTCGCCAGGCCTGGTACCGGCCAGCCAGCCCCGAAAGCCTGCATTACCACTTGTGCAGTGCCCCCCGGGCCCTGCTGCAGGATGTGCTGCCTAAGTATATCCTGGACTTCTCCCTCTTTGCCTACCCACTGCCTAATGTCACCAAGGAGGCGTGTCAGCAGTGACCATGGGTGTGGGGCCAGCAGCTGGTGGGGACTGGTTTCAACGCCAGCTTTCTGTGCTTCTGCCTGTCATTCGGAGAAACTCTGGCTCTGGGGCTTGGGGCTTCTCAGGATCCTGGATGGCAGAGACTGCCCTCAGAAGTTCCTTGTCCAGGGTGGGCACCCACAGTGACTCAGAGGACAGGGCTAGGCAGGAGACCTGCTGCTCCTCATTGGGGGGATCTCTTGGGGGGCAGACACCAGTTTGCCAATGAAGCAACACATCTGATCTAAAGACTGGCTCCAGACCCCGGGCTGCCAGGATTATGCAGTCCACTTGGTCTACCTTAATTTAACCTGTGGCCAAACTCAGAGATGGTACCAGCCAGGGGCAAGCATGACCAGAGCCAGGGACCCTGTGGCTCTGATCCCCCATTTATCCACCCCATGTGCCTCAGGACTAGAGTGAGCAATCATACCTTATAAATGACTTTTGTGCCTTTCTGCTCCAGTCTCAAAATTTCCTACACCTGCCAGTTCTTTACATTTTTCCAAGGAAAGGAAAACGGAAGCAGGGTTCTTGCCTGGTAGCTCCAGGACCCAGCTCTGCAGGCACCCAAAGACCCTCTGTGCCCAGCCTCTTCCTTGAGTTCTCGGAACCTCCTCCCTAATTCTCCCTTCCTTCCCCACAAGGCCTTTGAGGTTGTGACTGTGGCTGGTATATCTGGCTGCCATTTTTCTGATGCATTTATTTAAAATTTGTACTTTTTGATAGAACCCTTGTAAGGGCTTTGTTTTCCTAATAGCTGACTTTTTAATAAAGCAGTTTTATATATAAGGCGAGCATTTCTGTGATTTCCCTTGGAGCTCCTGTGGGCCCAGCAGATCTCCTCGATGTCTGTCTTCCCATGTCAGGGGAGGCAGCCTGTAGATAGAGAAAGTAAGGTATAACTTGGTTGGGCTGGTCCAATGGGCCGTTGCCATTCCATGGAGACTTTGGGGGCTTTCTAATAGGCTATACCAGATCACAGACTCAGATCCTGGGATGTCACCAAAGGGCAAGCCCAGTTAGGAATGGCCTCACGTCCAGAGCATACCTACATGTATTATTCCCTAAAAAAGTAGGTGGGTAGGAGATACGGGATCCTCCTCTTATTCAATAAGAGTTGAATGAGAAGTTCCCCCAGAGCATTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTGAGATGAAGTCTCGATCTGTCACCCAGGCTGCAGTGCAGTAGCACCATCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCTAGCGATTGCCTCAGCCTCCCAAGTAGCTGGGATGATTACAGGCACGCACCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTTTGAACTCCTAACCTCAGGTGATCTGCCCACCTCGGCCCCTCCAAAGTGCTAGGATTACAGGCGTGAGCTACCACGCCTGGCCCCGGACCATTTTCAAATGAAAAAGAAAATTTTTGTGTGAGCAAGGAGATTTTTTTCTGGCACTACAAGGAAGGCAGGCAAGGAGGTTGAGTGAGGGTCAGGCTCTTGTTGACTTAGGTCCAGAGAAAGTTGTGGAAGGAATACAGTTGGAGCAGCAGAGGACAGACTTCAGTATGGCCCATTGCCCCCACTGCTCTCCAGGGATCCCAGGCCCATCAGGAGTTGCTGGGCCCAAGGGAGAGTTGCAAGGCCAGAGCTGGCCCTTCTCTGTTAGCCCTATTTCACACACCCCCAGTGGGAAC
Task1_train_20531
Given a variant located on Chromosome 15 and affecting KNL1 (kinetochore scaffold 1), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Microcephaly 4, primary, autosomal recessive
TTAACTTTTCCGTATTTTAGATTAAAGCTTTCTGCATCGAACCAAGATAAGCTGTTGGTTGATATAAATAAGAACCTGTGGGAAAAAATGAGACACTGCTCTGACAAAGAGGTACTTTTGTCTCATTTTCTGAATGAGAATCAGTGAAGACATTCTGAACGATGTTTATTGTGAAATGAGTAACTGTTACTTGGTCATAGTGATGAGTTATTTAACTTATTTTTTAAGTGTAATGTGGTACCAAGGTCTTATTTAATTACACACAATTGTTAATATATAATCTTTTCAAACCTGAGATGATCAATTTAATATATGAAATATAGTTGAAGTTTATTTAGAGTTCCCTCCTTGCTATTTGCCTTTCACTTAGATTTAGACGAAGAAAAGATTTACTTTAATTGATTAAATAGCAAGCAACCCATTTTATATGTGCCCTAATATATTAAAAAGTTTCATTAACTAAGAGCCTGTCATTTTCTAATTTATAATATGAATAAGTGAATTAAAGGCAGGAATCAAAACTGAAATCTTTTTTCTGGTCTTAGACAATTACATGGAATTAAATTTGCAAATGACAAATATCCTGCCTTAGGATAGGCAAAGCCTAGCCTTCCTAGACCATTTACCTCTTCTGACTCGTTTGTTTTAGTACAGTGTTCTCTATAACTTTCCCTTCCAGCTGAAGGCCTTTGGAATTTATCTTAACAAAATAAAGTCATGTTTTACCAAGATGACTAAAGTCTTCACTCACCAAGGAAAAGTGGCTCTGTATGGCAAGCTGGTGCAGTCAGCTCAGGTAATTTGAGACAGTTAATATCATAGAAAGAGAGAGATATTAAAATTACTTTCTAATGGTTATAGAATATGAAGAATCTTCCTTAGAAGACATGTGAATAAGACTTGGGCAAAAACTTAACAATTAAGAGGTAAGGTTCAATTTGTCAAAAGTGGCAAATCCTGACATCTTGAGTAATACTGGAATATAATTACTAATGTGGGCCTATGTCTCATCTCAAATACTATTATCCATCATACATACTGAAATAAAATACATAGGATTCTGGTCTCCCATTGCTAAGGACTATACCATAGTATTATCTTCTTCATAGTCCATACTAAGCTGTATATGTATGCACATGTGTTTAAAGTAGCATTTCCCAAAATGATTAGCTTTTTTAAAAGGCTCTGCATAAAAAAACTTTCCATTGGCAAGTAAGTATGGGAAATGTTGCAAGCAATATGCCCTTTCAGAGAAACATAATTTTTTAAAGTCTAAGCATAAATGCTGTAATTCTTTTTGACCACTGTTTCCTATGTTTAGTTTATCATAGAAATGTTTTTAAGTAATAAATATTAATATATTGTATTCCATGGAACACCTATAGAAATGCTAAAATAAAGTACCAGAATTAGTTTTATGTCAATATGCTTTTTAAATTATTTCATTTTCTTTTAATAAAATATTTTATTAAATTTATAAAATAAACATTTTATTTTCCAGAGTTCTTTTGGCTAAAACTTATTTTAATAAAATTTACTTTTATTTTTTAAGTTCCAACCTAAAGCTTTGACCTTCATTTTAAGATTTGCCTGTTTGTAGGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGATCACGAGGTCGGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGCAGGCACCTGTAGTCCCAGCTAATCAGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCGGAGCTTGCAATGAGCCCAGATGGCGCCACTGCACTCCAGCCTGGGTAACAGAATGAGACTCCGCCTCAAAAAAAAAAAAAAAAAAAAAAGATTTGCCTGTTTGTGATCATGATAGAGCGATTATGTGAGCAGTTTGAACCATTTATAATATTTTCTTTAGAGGTTTAACTTGACAGTCTATAATCTTTTGTATTTAGAATGAGAGGGAGAAACTTCAAATAAAGATAGATGAGATGGATAAAATACTTAAGAAGATCGATAACTGCCTCACTGAGATGGAAACAGGTAAAGTATTTTAAATACTTTTCCAAAAGAAAATTTAATTTTATCTAAATGCTCTCCTACAGTAGAGAATGTTGGTACCACGATATTGAAGACTTGTATTAGCAACTTGAGATATTAAATTAGAGTAAATTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGCCGGGCGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATTTTAAAATTAGCTGGGCGTGGTGACGGGCGCCTGTACTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATAGTTTGAACCCAGGATGTGCAGGTTGCAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGTGGCAGAGCGAGACTCCATCTCAAAAAAAATAATAATAAAATAAATAAATAAATAAATTAGAGCAAATTAAAGTTCCTTTACTATAGTCATCCATAATACAATCAAGAGCTGCTCAAGATAACCCAGACTGTAATTTTGTGTTTTTTAATAGATGAATTTATCTCAGTTTGAAAACCGTCTATCCTTTCAGTTTGGTCTTTCATAATCCCAACTTTTTAGAGTTACTCTCCTGAAACTCCTTTCTCAAAGATCACATAATTCTGCATAGTCATCAAATTTTGTTCTTCTCAGTCCTTAGCCATTTTGACCTCTTTCAGCATTTGACACTGATGACTGTTCTTTTCTTCCTGAAATGTTCATCTCCCTTAATCTCTGTGATAATGCACTATCTTGACCCAGTTGTTTTCTCCTGGCTGCTCAATCCAGCTTCTCTGTTGGCCTCTCTTTCTCTAACTGATCCCTTGTGGGGATTTAGATTTTATCATCTGTTCTTTTCTATATTCTCTCCCCTAGTGCTTTCGTGTGCCTTAATAATTATGTGACTGATTCCCAAATTTAAATTCCTCAAGCATTTTTTGAGCATATACTGCATGCCAGATACTGTGCTTAGTATCAGAAAATAAATAAAAATATTTAAGACACAGATTTTGCCCTAAAGGTAGCTTATAATCATTTCAGGTGAGGGCATCTTTAGCCTCTCTTTCTTGAATTCTAGACTCAATTTCTAGCTTCCTTCTGAACCTGTATGCAAAAAATATCCTTAAACACCTTAAACTGTGAATACAGCCTGGGCAACAGAGTGAGGCACTATCTCTACAAAAAACAAGAGATTAGCTCAGCGTGATGGCACATACCTGTAGTCCTAGCTACTTGGGAGGCTGAGGCAGGAAGATCTCTTGAGCCCAGGAGGTCAAGACTACAGTGAGGCAAGATCACACCACTGCACTCCAGCCTGTGCAACAGAGCAAACTAAATAAATAAATTTAAATATATTCTCCGAGCTCAAAAATAAAATTCAAAAACTTGTTCTCTCTTATGATGTTTCTCATCTTTATGTATAGCAGTCACAATTCTTATACATTGTAAAAGCTCAATACTTTCATTGTCTTTGAGGCTCTCTTAACAAGTCCTGTCATCGGCAGCTTCAGCATCTCATGTGTTTATTTTCCTTTCCTATTAAGGCTCACCTTAATTCTGAACTGTGCTATTTCAGTCTTCTAACTAATCTTTATACATTCTTACCATTATTCCACCTTCTTCCATTCCAACCTGCACATTGCTGCCAGATTAATAATTATGAAAGACAGTTTTCATTAATGTTACTCCTCTGAAAAACTTCTGTCTTTCCATTTATTATAAAGTCCAAACTTAACTTTCTTTTTTTTTTTTTTTTTTGAGATGGTATTTCACTGTCGTTACCCAGGCTGGAGTCAATGGCACAATCTCTGCTCACTGCAACCTCCGCCTCCCAGATTCAAGCGATTTTCCTGCCTGAGCTTCCCGAGTAGCTGGGATTACAGGCATGCACCACCAGGCCCTGCTAATTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGATCTCGAACTCCCGACCTCA
TTAACTTTTCCGTATTTTAGATTAAAGCTTTCTGCATCGAACCAAGATAAGCTGTTGGTTGATATAAATAAGAACCTGTGGGAAAAAATGAGACACTGCTCTGACAAAGAGGTACTTTTGTCTCATTTTCTGAATGAGAATCAGTGAAGACATTCTGAACGATGTTTATTGTGAAATGAGTAACTGTTACTTGGTCATAGTGATGAGTTATTTAACTTATTTTTTAAGTGTAATGTGGTACCAAGGTCTTATTTAATTACACACAATTGTTAATATATAATCTTTTCAAACCTGAGATGATCAATTTAATATATGAAATATAGTTGAAGTTTATTTAGAGTTCCCTCCTTGCTATTTGCCTTTCACTTAGATTTAGACGAAGAAAAGATTTACTTTAATTGATTAAATAGCAAGCAACCCATTTTATATGTGCCCTAATATATTAAAAAGTTTCATTAACTAAGAGCCTGTCATTTTCTAATTTATAATATGAATAAGTGAATTAAAGGCAGGAATCAAAACTGAAATCTTTTTTCTGGTCTTAGACAATTACATGGAATTAAATTTGCAAATGACAAATATCCTGCCTTAGGATAGGCAAAGCCTAGCCTTCCTAGACCATTTACCTCTTCTGACTCGTTTGTTTTAGTACAGTGTTCTCTATAACTTTCCCTTCCAGCTGAAGGCCTTTGGAATTTATCTTAACAAAATAAAGTCATGTTTTACCAAGATGACTAAAGTCTTCACTCACCAAGGAAAAGTGGCTCTGTATGGCAAGCTGGTGCAGTCAGCTCAGGTAATTTGAGACAGTTAATATCATAGAAAGAGAGAGATATTAAAATTACTTTCTAATGGTTATAGAATATGAAGAATCTTCCTTAGAAGACATGTGAATAAGACTTGGGCAAAAACTTAACAATTAAGAGGTAAGGTTCAATTTGTCAAAAGTGGCAAATCCTGACATCTTGAGTAATACTGGAATATAATTACTAATGTGGGCCTATGTCTCATCTCAAATACTATTATCCATCATACATACTGAAATAAAATACATAGGATTCTGGTCTCCCATTGCTAAGGACTATACCATAGTATTATCTTCTTCATAGTCCATACTAAGCTGTATATGTATGCACATGTGTTTAAAGTAGCATTTCCCAAAATGATTAGCTTTTTTAAAAGGCTCTGCATAAAAAAACTTTCCATTGGCAAGTAAGTATGGGAAATGTTGCAAGCAATATGCCCTTTCAGAGAAACATAATTTTTTAAAGTCTAAGCATAAATGCTGTAATTCTTTTTGACCACTGTTTCCTATGTTTAGTTTATCATAGAAATGTTTTTAAGTAATAAATATTAATATATTGTATTCCATGGAACACCTATAGAAATGCTAAAATAAAGTACCAGAATTAGTTTTATGTCAATATGCTTTTTAAATTATTTCATTTTCTTTTAATAAAATATTTTATTAAATTTATAAAATAAACATTTTATTTTCCAGAGTTCTTTTGGCTAAAACTTATTTTAATAAAATTTACTTTTATTTTTTAAGTTCCAACCTAAAGCTTTGACCTTCATTTTAAGATTTGCCTGTTTGTAGGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGATCACGAGGTCGGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGCAGGCACCTGTAGTCCCAGCTAATCAGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCGGAGCTTGCAATGAGCCCAGATGGCGCCACTGCACTCCAGCCTGGGTAACAGAATGAGACTCCGCCTCAAAAAAAAAAAAAAAAAAAAAAGATTTGCCTGTTTGTGATCATGATAGAGCGATTATGTGAGCAGTTTGAACCATTTATAATATTTTCTTTAGAGGTTTAACTTGACAGTCTATAATCTTTTGTATTTAGAATGAGAGGGAGAAACTTCAAATAAAGATAGATGAGATAGATAAAATACTTAAGAAGATCGATAACTGCCTCACTGAGATGGAAACAGGTAAAGTATTTTAAATACTTTTCCAAAAGAAAATTTAATTTTATCTAAATGCTCTCCTACAGTAGAGAATGTTGGTACCACGATATTGAAGACTTGTATTAGCAACTTGAGATATTAAATTAGAGTAAATTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGCCGGGCGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATTTTAAAATTAGCTGGGCGTGGTGACGGGCGCCTGTACTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATAGTTTGAACCCAGGATGTGCAGGTTGCAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGGTGGCAGAGCGAGACTCCATCTCAAAAAAAATAATAATAAAATAAATAAATAAATAAATTAGAGCAAATTAAAGTTCCTTTACTATAGTCATCCATAATACAATCAAGAGCTGCTCAAGATAACCCAGACTGTAATTTTGTGTTTTTTAATAGATGAATTTATCTCAGTTTGAAAACCGTCTATCCTTTCAGTTTGGTCTTTCATAATCCCAACTTTTTAGAGTTACTCTCCTGAAACTCCTTTCTCAAAGATCACATAATTCTGCATAGTCATCAAATTTTGTTCTTCTCAGTCCTTAGCCATTTTGACCTCTTTCAGCATTTGACACTGATGACTGTTCTTTTCTTCCTGAAATGTTCATCTCCCTTAATCTCTGTGATAATGCACTATCTTGACCCAGTTGTTTTCTCCTGGCTGCTCAATCCAGCTTCTCTGTTGGCCTCTCTTTCTCTAACTGATCCCTTGTGGGGATTTAGATTTTATCATCTGTTCTTTTCTATATTCTCTCCCCTAGTGCTTTCGTGTGCCTTAATAATTATGTGACTGATTCCCAAATTTAAATTCCTCAAGCATTTTTTGAGCATATACTGCATGCCAGATACTGTGCTTAGTATCAGAAAATAAATAAAAATATTTAAGACACAGATTTTGCCCTAAAGGTAGCTTATAATCATTTCAGGTGAGGGCATCTTTAGCCTCTCTTTCTTGAATTCTAGACTCAATTTCTAGCTTCCTTCTGAACCTGTATGCAAAAAATATCCTTAAACACCTTAAACTGTGAATACAGCCTGGGCAACAGAGTGAGGCACTATCTCTACAAAAAACAAGAGATTAGCTCAGCGTGATGGCACATACCTGTAGTCCTAGCTACTTGGGAGGCTGAGGCAGGAAGATCTCTTGAGCCCAGGAGGTCAAGACTACAGTGAGGCAAGATCACACCACTGCACTCCAGCCTGTGCAACAGAGCAAACTAAATAAATAAATTTAAATATATTCTCCGAGCTCAAAAATAAAATTCAAAAACTTGTTCTCTCTTATGATGTTTCTCATCTTTATGTATAGCAGTCACAATTCTTATACATTGTAAAAGCTCAATACTTTCATTGTCTTTGAGGCTCTCTTAACAAGTCCTGTCATCGGCAGCTTCAGCATCTCATGTGTTTATTTTCCTTTCCTATTAAGGCTCACCTTAATTCTGAACTGTGCTATTTCAGTCTTCTAACTAATCTTTATACATTCTTACCATTATTCCACCTTCTTCCATTCCAACCTGCACATTGCTGCCAGATTAATAATTATGAAAGACAGTTTTCATTAATGTTACTCCTCTGAAAAACTTCTGTCTTTCCATTTATTATAAAGTCCAAACTTAACTTTCTTTTTTTTTTTTTTTTTTGAGATGGTATTTCACTGTCGTTACCCAGGCTGGAGTCAATGGCACAATCTCTGCTCACTGCAACCTCCGCCTCCCAGATTCAAGCGATTTTCCTGCCTGAGCTTCCCGAGTAGCTGGGATTACAGGCATGCACCACCAGGCCCTGCTAATTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGATCTCGAACTCCCGACCTCA
Task1_train_20532
This variant affects gene RAD51 (RAD51 recombinase) located on Chromosome 15. Evaluate its biological effect and specify any disease association.
Pathogenic; Fanconi anemia complementation group R
TCTGTCACCCAGGCTGGAGTGCAGTGGCATGGTCTCAGCTCACTGCAACCTCTGCTTCCTGGGCTCAAGTGATCTTCTAGCCTCAGTCTCCCCAAGCTAGGACTATGATCATTTACCACCTGGCTAATTTTTTTTTTTTTTTTTTTTTTTTTTGAGTCGGGGCATCACTCATTATGTTGCCCAGGCTGGTCTCAAAATCCTGAGCTCAAGCCATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTATAGGCTTGAGCCACCTTGCCTGGCCCAATGTCAGTTTTCTTTCCCTTTTTTTTGAGACAGAGTCTCACTCTGTTACCCAGGCTGGAGTGCAGTGGCATAATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCAAGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTCACCACGTTGGCTAGGTTGGTCTCGAACTCCTGACCTCAGATGATCTACCCGCCTCAGCCTCCCAAAGTGCTGGGCTTACAGGCGTGAGCCATCATGCCTGGCCCCCAATGTCAGTTTTCTAATATCAGTGCTATACTATCATTATGCAAGAGGTTAACACTGCAGAAGGCTAGGTGCATAGAAATTTCGTATGTTTTTTTTTGTTGTTGTTGGTTTGTTTGTTTGTTTTTTAAAGACAGAGTCTTGCTCTGTTGCCCAGGCTAGAATGCAGTGGCACAATCTCGGCTCATTGCAACCACTGACTCCCAGGTTTGAGCAGTTCTCCTGCCTCAGTCTCCTGAGTAGCTGCAATGACAGGCACCCGCCACCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGATTTCACCGTCTTGGCCAGGCTGGTCTCAAAGTCCTGACCTCCTGATCCATCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCTTTTTTTTTTTTTTTTTTTTTTGAGATGGGGTCTTGCTATGTCACCCCGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCCACTTCCGCCCCCAGGTTCAAGCTATTCTTCTGCCTCCGCCTCCCGAGTAGCTGGGACTACAGGCATGCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTGTGCCCAGCTTTTTTTTTTTTTTTTTTGAGGAGTCTCACTTTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTTGCTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCTTCAGCCTGCTAGTAGCTGGGATTACAGGTGCCCATCACCAGTTCCAGCTAAGTTTTGTATTTTTAGTAGACATGAGGTTTCACCATGTTGGCCAGGCTGGTCTCGAGCTCCTGACCTCAGGTGATCAGCCCGCCTCGGCCCCCTAAAGTGCTGGGATTACAGGTGTGAGCCACCGCACCTGGCCTTATTTGCAGCTATCTATAAATCTAATTATTTCAAAATACTTTTGGTTTATTTGTTTGTTTGTTTGTTTGTTTTGAAACAGGGTCTCACTGTGTCACCCAGGCTAGAGTGCACTGGCACGATTTTGGCTCACTGCAACTTCTGCCTCCCAGGCTCAAGTGATCCTCTCACCTTAGCTCCTGAGTAGCTGGTACTACAGGCATCCGCCACCATGCCCGGCTAATTTTTGTAGAGACAGGGCTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTGAACTCAAGCAATCCACCCACCTAAGCTTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGGCTAGCCTCAAAATACATTTGTGAAAAATTATCGCTTGTTGGAAATTGAATTTTTAACTTACATAAACATCTTTCTGATGAGCTCCAAGAACATTTCTATGACTACAGTTTCTACATGTTTGTATTATGCTAAGAGTTATTTCTTATCGCTTTTTTAGGTGGAATTGAGACTGGATCTATCACAGAAATGTTTGGAGAATTCCGAACTGGGAAGACCCAGATCTGTCATACGCTAGCTGTCACCTGCCAGGTGAGCTGTTGGGGCTATAGCTAATCAAATAAGCAAGCATTACTTCATTCCTGCTATTTGCAAGCATCTGTTAGGATGGCCATAAAAGGTACTTTCTCTGTCCTCAAGAATCTTATAGCTGTTAATAGTTAGAAGATAGACTCCTACTTCAAAATCCTTCCATGTCATAGAAACTTCCAAATCATTGATCTCCTATCAGATACGTTAATTTCAAATACTTTTGCTACCAGGCCTTTTCCTGGCTTTACTTGCTACTTTTTTTTTTTTTTTTTTTTTTTGAGGCAGAATCTCGCTGTGTCGCCCAGGCTGAAGTACAGTGGTGTGATCTCAGCTCACTGCAACCTCCTCTCTGGTTCAAGTGATTCTCCTTCATCAACCTCCCGAGTACCTGGGATTACAGGCGCCCACCAGCATGCCCGGCTAATTTTTGTGTTTTTAGTAGAGAGGGGGTTTCACCATGTTGGCCAGGCTCCTCTTGAACTCCTGATCTCAAGTGATCCACCCACCTTGGCCTCCCAAGTGCTGGAATTATAGGCGTAAGCCACTGCGCCCAGCCCTCCATCTTCTTCATTAGTCTAGATTTTATGATTCATCATTAAAGTAATTCTCTTGCAGATAGCCTCAGTTTACATACCCACTTGAAGAGATGCCAACCTTAGATGAAACTCATCTATCTTCTCAGTGTCTGTACCCAAATAGCTGATTATACTGGAGAAAAATCGTATCATACAGCTGACTGACTTCACTTTAAATTCAAGATGACAGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGTACTTTGGGAGGCCGAGGCGGGTGGATCACTTGAGATCAAGAGTTTGGCTGGGCGCGGTGACTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACAAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGTTGGGCGTGGTGGCGGGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCACAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAGAAGAAAAAAAAAAGATCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGTTGGCACGTGCCTGTAATCCCAGTTACTTGGGAGACTGAGGCAGGAGAATCGCTTGAACCCGGGGGGCAGAGGTTGCAGGGAGCTGAGATCGCACCATTGCATTCCAGCCTGGTCAAAGAAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAGAATGAAAAAAGGAAAAAAATTCAAGATGACAAAACTTTAGATTAACATTCAAAACTTCTTGGCAGTCTACTTTCTCCATTTAGGTGTACTTTCCCACTGAGTTAGACAGGCATCTCATATCTCATACTTCGTCTTCTGTTATCAGAACTTTATGCTCCTCTTCAACTCTCATTCTTAGCCAAAAACCTAACCTGCTCTTTGCATCAAATCTACATTTGTGCCCATCTTTTCTTATCTCAGGTTACAATTGAGAAAGTGTCCCTTTTCTTCTCAAAGGCCCATTCTATCAATATGATTTGGTTACCATCTCCTGCCACCTTCTCAAGGACTCTACTCCTTCCATTTTCTCTTGTACCTCTCTATGAGATTATCCTCATCAGTATACAAATATGTCTAGTGTCTCCTCCATTAGGAAAAAACCTTCCCTGGACCCCTTCAGTTTCTTTTTCCTTTACTTATGCTCCTATTGGTGGGAAGATTTGGAAATAGACACAGTAGGTTAAATAATTGCCCAATACATTGTATTTAAGTAGCAAATACTGGACTCAAACCAGACTTCAGAGATGATGTTCTTAAAACTTCATAAGAGGCCAG
TCTGTCACCCAGGCTGGAGTGCAGTGGCATGGTCTCAGCTCACTGCAACCTCTGCTTCCTGGGCTCAAGTGATCTTCTAGCCTCAGTCTCCCCAAGCTAGGACTATGATCATTTACCACCTGGCTAATTTTTTTTTTTTTTTTTTTTTTTTTTGAGTCGGGGCATCACTCATTATGTTGCCCAGGCTGGTCTCAAAATCCTGAGCTCAAGCCATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTATAGGCTTGAGCCACCTTGCCTGGCCCAATGTCAGTTTTCTTTCCCTTTTTTTTGAGACAGAGTCTCACTCTGTTACCCAGGCTGGAGTGCAGTGGCATAATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCAAGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTCACCACGTTGGCTAGGTTGGTCTCGAACTCCTGACCTCAGATGATCTACCCGCCTCAGCCTCCCAAAGTGCTGGGCTTACAGGCGTGAGCCATCATGCCTGGCCCCCAATGTCAGTTTTCTAATATCAGTGCTATACTATCATTATGCAAGAGGTTAACACTGCAGAAGGCTAGGTGCATAGAAATTTCGTATGTTTTTTTTTGTTGTTGTTGGTTTGTTTGTTTGTTTTTTAAAGACAGAGTCTTGCTCTGTTGCCCAGGCTAGAATGCAGTGGCACAATCTCGGCTCATTGCAACCACTGACTCCCAGGTTTGAGCAGTTCTCCTGCCTCAGTCTCCTGAGTAGCTGCAATGACAGGCACCCGCCACCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGATTTCACCGTCTTGGCCAGGCTGGTCTCAAAGTCCTGACCTCCTGATCCATCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCTTTTTTTTTTTTTTTTTTTTTTGAGATGGGGTCTTGCTATGTCACCCCGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCCACTTCCGCCCCCAGGTTCAAGCTATTCTTCTGCCTCCGCCTCCCGAGTAGCTGGGACTACAGGCATGCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTGTGCCCAGCTTTTTTTTTTTTTTTTTTGAGGAGTCTCACTTTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTTGCTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCTTCAGCCTGCTAGTAGCTGGGATTACAGGTGCCCATCACCAGTTCCAGCTAAGTTTTGTATTTTTAGTAGACATGAGGTTTCACCATGTTGGCCAGGCTGGTCTCGAGCTCCTGACCTCAGGTGATCAGCCCGCCTCGGCCCCCTAAAGTGCTGGGATTACAGGTGTGAGCCACCGCACCTGGCCTTATTTGCAGCTATCTATAAATCTAATTATTTCAAAATACTTTTGGTTTATTTGTTTGTTTGTTTGTTTGTTTTGAAACAGGGTCTCACTGTGTCACCCAGGCTAGAGTGCACTGGCACGATTTTGGCTCACTGCAACTTCTGCCTCCCAGGCTCAAGTGATCCTCTCACCTTAGCTCCTGAGTAGCTGGTACTACAGGCATCCGCCACCATGCCCGGCTAATTTTTGTAGAGACAGGGCTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTGAACTCAAGCAATCCACCCACCTAAGCTTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGGCTAGCCTCAAAATACATTTGTGAAAAATTATCGCTTGTTGGAAATTGAATTTTTAACTTACATAAACATCTTTCTGATGAGCTCCAAGAACATTTCTATGACTACAGTTTCTACATGTTTGTATTATGCTAAGAGTTATTTCTTATCGCTTTTTTAGGTGGAATTGAGACTGGATCTATCACAGAAATGTTTGGAGAATTCCGACCTGGGAAGACCCAGATCTGTCATACGCTAGCTGTCACCTGCCAGGTGAGCTGTTGGGGCTATAGCTAATCAAATAAGCAAGCATTACTTCATTCCTGCTATTTGCAAGCATCTGTTAGGATGGCCATAAAAGGTACTTTCTCTGTCCTCAAGAATCTTATAGCTGTTAATAGTTAGAAGATAGACTCCTACTTCAAAATCCTTCCATGTCATAGAAACTTCCAAATCATTGATCTCCTATCAGATACGTTAATTTCAAATACTTTTGCTACCAGGCCTTTTCCTGGCTTTACTTGCTACTTTTTTTTTTTTTTTTTTTTTTTGAGGCAGAATCTCGCTGTGTCGCCCAGGCTGAAGTACAGTGGTGTGATCTCAGCTCACTGCAACCTCCTCTCTGGTTCAAGTGATTCTCCTTCATCAACCTCCCGAGTACCTGGGATTACAGGCGCCCACCAGCATGCCCGGCTAATTTTTGTGTTTTTAGTAGAGAGGGGGTTTCACCATGTTGGCCAGGCTCCTCTTGAACTCCTGATCTCAAGTGATCCACCCACCTTGGCCTCCCAAGTGCTGGAATTATAGGCGTAAGCCACTGCGCCCAGCCCTCCATCTTCTTCATTAGTCTAGATTTTATGATTCATCATTAAAGTAATTCTCTTGCAGATAGCCTCAGTTTACATACCCACTTGAAGAGATGCCAACCTTAGATGAAACTCATCTATCTTCTCAGTGTCTGTACCCAAATAGCTGATTATACTGGAGAAAAATCGTATCATACAGCTGACTGACTTCACTTTAAATTCAAGATGACAGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGTACTTTGGGAGGCCGAGGCGGGTGGATCACTTGAGATCAAGAGTTTGGCTGGGCGCGGTGACTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACAAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGTTGGGCGTGGTGGCGGGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCACAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAGAAGAAAAAAAAAAGATCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGTTGGCACGTGCCTGTAATCCCAGTTACTTGGGAGACTGAGGCAGGAGAATCGCTTGAACCCGGGGGGCAGAGGTTGCAGGGAGCTGAGATCGCACCATTGCATTCCAGCCTGGTCAAAGAAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAGAATGAAAAAAGGAAAAAAATTCAAGATGACAAAACTTTAGATTAACATTCAAAACTTCTTGGCAGTCTACTTTCTCCATTTAGGTGTACTTTCCCACTGAGTTAGACAGGCATCTCATATCTCATACTTCGTCTTCTGTTATCAGAACTTTATGCTCCTCTTCAACTCTCATTCTTAGCCAAAAACCTAACCTGCTCTTTGCATCAAATCTACATTTGTGCCCATCTTTTCTTATCTCAGGTTACAATTGAGAAAGTGTCCCTTTTCTTCTCAAAGGCCCATTCTATCAATATGATTTGGTTACCATCTCCTGCCACCTTCTCAAGGACTCTACTCCTTCCATTTTCTCTTGTACCTCTCTATGAGATTATCCTCATCAGTATACAAATATGTCTAGTGTCTCCTCCATTAGGAAAAAACCTTCCCTGGACCCCTTCAGTTTCTTTTTCCTTTACTTATGCTCCTATTGGTGGGAAGATTTGGAAATAGACACAGTAGGTTAAATAATTGCCCAATACATTGTATTTAAGTAGCAAATACTGGACTCAAACCAGACTTCAGAGATGATGTTCTTAAAACTTCATAAGAGGCCAG
Task1_train_20533
This sequence change occurs on Chromosome 15, altering RAD51 (RAD51 recombinase). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Mirror movements 2
CCACATCAGCCTCCCAAATTGCTGGGATTACAGGTGTGAGCCACTGCGCCCAGCCATATCAGTGTTTCTTGAGGCAGAACTAGAAGACTTGTGCAGTAAAGTACTTACACCTGTTACATCTTTTTTTTTTCACCATACATTCATGATCTAAATAGAGAAAACTTATATCTCTTCATTCTTGTTTTATTTGGTCAGGATCGTAAGGTGTAACTCTATCCTAATGCCATCTGTTTATCCTCATGACAGAATCGTGAACCTAGAACATAATCATAGCACACTGGGTTTTATGTAAACATTCTCTTTTTTTTTTTTTTTTTGAGATGGAATCTCACTCTGTCACCCAGTCTGGTGTGCAATGGTATGATCTCGACTCACTGCAACTTCTGTCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGACCAGGCTGGTCTCCGACTCCTGACATCAGGTGATCCACCTGCCTCGGCATCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGCACCTGGCCCTCAAAGAATAGGTTTGATTTAGGTCAGGCGTGGTGGCTCACGCCTGTAGTCCCAGTATTTTGGGAGGCCAAGGTGGGCGGATTATGAGATCAGGAGGTCAAGACCAGCCTGATCAATATGGTGAAACCCTGTCTCTACTAAAAATAAAAATATTAGCTATGCATGGTGCTGCATAGCTCCATGCTACTTTGGAGGCTGAGGCAGGAGAATCGCGTGAACCCAGGAGGTGGAGGTTGCAATGAGATCACGCCGCTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAGAAAAAAAAAAAAGAATGGATTTGATTTATCCCAAAGACTTGCCAGGTAGAGCTCCAGAGTAGTTGGGTGCTATCATCTCTCTGCTTATAGTTTGCCTGAACTTCTTAATAGAAAGGGAAATACATTCTTTGGTCCTGAAACTACTGTCAGTACCACTTCTTCCCTACCTATTCAGGTAATTTAAGTGTCAGAAACAAATTGCTCATCTGCCTGAGTTCTGTGTGCAGCCTAAAAATGTTCTCTCCTCTCTCATAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGTGTTCAGTATAAGACACCAAATATGTTCTTAAGAGTCCTTCCCTGAATCTTGTAATGGCTATTTGGCCAGATTGATAGTAGTTTGAATTAGAAATGAGGAGGTTTAAGTATAATTCCTGTGTTGACACTCTTGCTTTGTAGTTTAGGTCAAGTCACTATTAAAAATGAAACCATAATCTACTTGAACTTGCTGGAAATCTTGTTAAACGGTGCCTCAGATGTTAGTACTGTGCAAATATTTTAATAAAACATCTATATACAGGCCGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACAAGGTCAGGAGATCGAGAACATCCTGGCTAACACGGTGAATCCGTCTCTACTAAAAAAATACAAAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCCGGAGGCTGAAGCAGGAGAATGGAGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCAAGAATGCCCCACTGCACTCCAGCCTGGGCGACAGAGCTAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAATCTGTATACAGGAAAAACTATGAATATGAGATTTTAGGGTGGTAAGGAAGGGACCAGAATCTGACACAGGCTAGAAATAGGCTTCAGAGAATCCTTGTTTCCTGTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGGTAAGTTGTGGGATAGGGACAGAGAATGCCTACTTTCAGTGGCTGTGAATTCCAGGAGCCTTGCTAGGAGGCTAAGACATCAGTGCCTGAGATCATCAAGCTCTTAGGAAGAAGAGAGACATTAGTTATTCGTTATTTTGTGGGGGAAAGTGGTGGCAGCATTAAGGCTTTTGGAGTGTCTATGGCCACAAAATTGACATTTATCCTTTCCCCATCAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGGTAAGGTGTTGATGGGATCAGTTCTTCTTTTCGGAATGTCATATTAACTGTGAAGACATGAAGATATAACATTTTCATTTAAGCCCTGTTAAAGCTACTGTTGTATAGACACTTAGGAACTCTTGCTAATCTAATTAACATGCTCTCGTTGGTATAGATGTTTTAGTTCATAAAAGAATTAAAAACCCACAAGTGTGGAAGAATGAATATGAGTAATTGATATGCCTCTCCCCTGTTATTTAAAAAATGTTTGGGCTGGGCACAGTGGCTCACACTGGTAATCCCAACACTTTGGGAGGCCAAGGTGATAGGATGGTTTGAGGCCAGGAATTCGACACTAGTAAGGGCAACAAAGTGAGGCCTCTGTCTCTACAAAAAAAAGTAGCTGGTGTGGTGGCGTGTGCCTGTAGTCTTAGCTACCCAGGAGACTGAGGCAGGAGGATCAGTTGAGCATAGGAATTCGAGGCTGTATTGAGCTATGATCACACATCACTGCACTCCAGCCTGGCAAAAGAGCAGGACACTGTCTTGAAAAAATTTTTTTTCTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACAGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCAACTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCCTAAATTTTTCTTTTTTTAATGTTTGTTTCAATATGGACAATCCACTGAGAGGGGCCAGGGCAAAAATGGATTCTGCCAGGTTGGAAATGCACTAAGGAAAACAGTACAGAAACATTCCCAGGGTCCTTCTAGGAAGAATATATGTCTAAAAAATTTTCAGCTCTGTTACAAAGTCAGGAACGGAATTGTTTAATTATAATAAATTGGTGCTTTGGTCTGTGTCTTTGGGTCAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTC
CCACATCAGCCTCCCAAATTGCTGGGATTACAGGTGTGAGCCACTGCGCCCAGCCATATCAGTGTTTCTTGAGGCAGAACTAGAAGACTTGTGCAGTAAAGTACTTACACCTGTTACATCTTTTTTTTTTCACCATACATTCATGATCTAAATAGAGAAAACTTATATCTCTTCATTCTTGTTTTATTTGGTCAGGATCGTAAGGTGTAACTCTATCCTAATGCCATCTGTTTATCCTCATGACAGAATCGTGAACCTAGAACATAATCATAGCACACTGGGTTTTATGTAAACATTCTCTTTTTTTTTTTTTTTTTGAGATGGAATCTCACTCTGTCACCCAGTCTGGTGTGCAATGGTATGATCTCGACTCACTGCAACTTCTGTCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGACCAGGCTGGTCTCCGACTCCTGACATCAGGTGATCCACCTGCCTCGGCATCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGCACCTGGCCCTCAAAGAATAGGTTTGATTTAGGTCAGGCGTGGTGGCTCACGCCTGTAGTCCCAGTATTTTGGGAGGCCAAGGTGGGCGGATTATGAGATCAGGAGGTCAAGACCAGCCTGATCAATATGGTGAAACCCTGTCTCTACTAAAAATAAAAATATTAGCTATGCATGGTGCTGCATAGCTCCATGCTACTTTGGAGGCTGAGGCAGGAGAATCGCGTGAACCCAGGAGGTGGAGGTTGCAATGAGATCACGCCGCTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAGAAAAAAAAAAAAGAATGGATTTGATTTATCCCAAAGACTTGCCAGGTAGAGCTCCAGAGTAGTTGGGTGCTATCATCTCTCTGCTTATAGTTTGCCTGAACTTCTTAATAGAAAGGGAAATACATTCTTTGGTCCTGAAACTACTGTCAGTACCACTTCTTCCCTACCTATTCAGGTAATTTAAGTGTCAGAAACAAATTGCTCATCTGCCTGAGTTCTGTGTGCAGCCTAAAAATGTTCTCTCCTCTCTCATAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGTGTTCAGTATAAGACACCAAATATGTTCTTAAGAGTCCTTCCCTGAATCTTGTAATGGCTATTTGGCCAGATTGATAGTAGTTTGAATTAGAAATGAGGAGGTTTAAGTATAATTCCTGTGTTGACACTCTTGCTTTGTAGTTTAGGTCAAGTCACTATTAAAAATGAAACCATAATCTACTTGAACTTGCTGGAAATCTTGTTAAACGGTGCCTCAGATGTTAGTACTGTGCAAATATTTTAATAAAACATCTATATACAGGCCGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACAAGGTCAGGAGATCGAGAACATCCTGGCTAACACGGTGAATCCGTCTCTACTAAAAAAATACAAAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCCGGAGGCTGAAGCAGGAGAATGGAGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCAAGAATGCCCCACTGCACTCCAGCCTGGGCGACAGAGCTAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAATCTGTATACAGGAAAAACTATGAATATGAGATTTTAGGGTGGTAAGGAAGGGACCAGAATCTGACACAGGCTAGAAATAGGCTTCAGAGAATCCTTGTTTCCTGTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCAGATGCTTCTGCGACTCGCTGATGAGGTAAGTTGTGGGATAGGGACAGAGAATGCCTACTTTCAGTGGCTGTGAATTCCAGGAGCCTTGCTAGGAGGCTAAGACATCAGTGCCTGAGATCATCAAGCTCTTAGGAAGAAGAGAGACATTAGTTATTCGTTATTTTGTGGGGGAAAGTGGTGGCAGCATTAAGGCTTTTGGAGTGTCTATGGCCACAAAATTGACATTTATCCTTTCCCCATCAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGGTAAGGTGTTGATGGGATCAGTTCTTCTTTTCGGAATGTCATATTAACTGTGAAGACATGAAGATATAACATTTTCATTTAAGCCCTGTTAAAGCTACTGTTGTATAGACACTTAGGAACTCTTGCTAATCTAATTAACATGCTCTCGTTGGTATAGATGTTTTAGTTCATAAAAGAATTAAAAACCCACAAGTGTGGAAGAATGAATATGAGTAATTGATATGCCTCTCCCCTGTTATTTAAAAAATGTTTGGGCTGGGCACAGTGGCTCACACTGGTAATCCCAACACTTTGGGAGGCCAAGGTGATAGGATGGTTTGAGGCCAGGAATTCGACACTAGTAAGGGCAACAAAGTGAGGCCTCTGTCTCTACAAAAAAAAGTAGCTGGTGTGGTGGCGTGTGCCTGTAGTCTTAGCTACCCAGGAGACTGAGGCAGGAGGATCAGTTGAGCATAGGAATTCGAGGCTGTATTGAGCTATGATCACACATCACTGCACTCCAGCCTGGCAAAAGAGCAGGACACTGTCTTGAAAAAATTTTTTTTCTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACAGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCAACTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCCTAAATTTTTCTTTTTTTAATGTTTGTTTCAATATGGACAATCCACTGAGAGGGGCCAGGGCAAAAATGGATTCTGCCAGGTTGGAAATGCACTAAGGAAAACAGTACAGAAACATTCCCAGGGTCCTTCTAGGAAGAATATATGTCTAAAAAATTTTCAGCTCTGTTACAAAGTCAGGAACGGAATTGTTTAATTATAATAAATTGGTGCTTTGGTCTGTGTCTTTGGGTCAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTC
Task1_train_20534
This variant affects gene RAD51 (RAD51 recombinase) located on Chromosome 15. Evaluate its biological effect and specify any disease association.
Pathogenic; RAD51-related disorder
TGGTGTGCAATGGTATGATCTCGACTCACTGCAACTTCTGTCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGACCAGGCTGGTCTCCGACTCCTGACATCAGGTGATCCACCTGCCTCGGCATCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGCACCTGGCCCTCAAAGAATAGGTTTGATTTAGGTCAGGCGTGGTGGCTCACGCCTGTAGTCCCAGTATTTTGGGAGGCCAAGGTGGGCGGATTATGAGATCAGGAGGTCAAGACCAGCCTGATCAATATGGTGAAACCCTGTCTCTACTAAAAATAAAAATATTAGCTATGCATGGTGCTGCATAGCTCCATGCTACTTTGGAGGCTGAGGCAGGAGAATCGCGTGAACCCAGGAGGTGGAGGTTGCAATGAGATCACGCCGCTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAGAAAAAAAAAAAAGAATGGATTTGATTTATCCCAAAGACTTGCCAGGTAGAGCTCCAGAGTAGTTGGGTGCTATCATCTCTCTGCTTATAGTTTGCCTGAACTTCTTAATAGAAAGGGAAATACATTCTTTGGTCCTGAAACTACTGTCAGTACCACTTCTTCCCTACCTATTCAGGTAATTTAAGTGTCAGAAACAAATTGCTCATCTGCCTGAGTTCTGTGTGCAGCCTAAAAATGTTCTCTCCTCTCTCATAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGTGTTCAGTATAAGACACCAAATATGTTCTTAAGAGTCCTTCCCTGAATCTTGTAATGGCTATTTGGCCAGATTGATAGTAGTTTGAATTAGAAATGAGGAGGTTTAAGTATAATTCCTGTGTTGACACTCTTGCTTTGTAGTTTAGGTCAAGTCACTATTAAAAATGAAACCATAATCTACTTGAACTTGCTGGAAATCTTGTTAAACGGTGCCTCAGATGTTAGTACTGTGCAAATATTTTAATAAAACATCTATATACAGGCCGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACAAGGTCAGGAGATCGAGAACATCCTGGCTAACACGGTGAATCCGTCTCTACTAAAAAAATACAAAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCCGGAGGCTGAAGCAGGAGAATGGAGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCAAGAATGCCCCACTGCACTCCAGCCTGGGCGACAGAGCTAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAATCTGTATACAGGAAAAACTATGAATATGAGATTTTAGGGTGGTAAGGAAGGGACCAGAATCTGACACAGGCTAGAAATAGGCTTCAGAGAATCCTTGTTTCCTGTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGGTAAGTTGTGGGATAGGGACAGAGAATGCCTACTTTCAGTGGCTGTGAATTCCAGGAGCCTTGCTAGGAGGCTAAGACATCAGTGCCTGAGATCATCAAGCTCTTAGGAAGAAGAGAGACATTAGTTATTCGTTATTTTGTGGGGGAAAGTGGTGGCAGCATTAAGGCTTTTGGAGTGTCTATGGCCACAAAATTGACATTTATCCTTTCCCCATCAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGGTAAGGTGTTGATGGGATCAGTTCTTCTTTTCGGAATGTCATATTAACTGTGAAGACATGAAGATATAACATTTTCATTTAAGCCCTGTTAAAGCTACTGTTGTATAGACACTTAGGAACTCTTGCTAATCTAATTAACATGCTCTCGTTGGTATAGATGTTTTAGTTCATAAAAGAATTAAAAACCCACAAGTGTGGAAGAATGAATATGAGTAATTGATATGCCTCTCCCCTGTTATTTAAAAAATGTTTGGGCTGGGCACAGTGGCTCACACTGGTAATCCCAACACTTTGGGAGGCCAAGGTGATAGGATGGTTTGAGGCCAGGAATTCGACACTAGTAAGGGCAACAAAGTGAGGCCTCTGTCTCTACAAAAAAAAGTAGCTGGTGTGGTGGCGTGTGCCTGTAGTCTTAGCTACCCAGGAGACTGAGGCAGGAGGATCAGTTGAGCATAGGAATTCGAGGCTGTATTGAGCTATGATCACACATCACTGCACTCCAGCCTGGCAAAAGAGCAGGACACTGTCTTGAAAAAATTTTTTTTCTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACAGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCAACTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCCTAAATTTTTCTTTTTTTAATGTTTGTTTCAATATGGACAATCCACTGAGAGGGGCCAGGGCAAAAATGGATTCTGCCAGGTTGGAAATGCACTAAGGAAAACAGTACAGAAACATTCCCAGGGTCCTTCTAGGAAGAATATATGTCTAAAAAATTTTCAGCTCTGTTACAAAGTCAGGAACGGAATTGTTTAATTATAATAAATTGGTGCTTTGGTCTGTGTCTTTGGGTCAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTA
TGGTGTGCAATGGTATGATCTCGACTCACTGCAACTTCTGTCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGACCAGGCTGGTCTCCGACTCCTGACATCAGGTGATCCACCTGCCTCGGCATCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGCACCTGGCCCTCAAAGAATAGGTTTGATTTAGGTCAGGCGTGGTGGCTCACGCCTGTAGTCCCAGTATTTTGGGAGGCCAAGGTGGGCGGATTATGAGATCAGGAGGTCAAGACCAGCCTGATCAATATGGTGAAACCCTGTCTCTACTAAAAATAAAAATATTAGCTATGCATGGTGCTGCATAGCTCCATGCTACTTTGGAGGCTGAGGCAGGAGAATCGCGTGAACCCAGGAGGTGGAGGTTGCAATGAGATCACGCCGCTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAGAAAAAAAAAAAAGAATGGATTTGATTTATCCCAAAGACTTGCCAGGTAGAGCTCCAGAGTAGTTGGGTGCTATCATCTCTCTGCTTATAGTTTGCCTGAACTTCTTAATAGAAAGGGAAATACATTCTTTGGTCCTGAAACTACTGTCAGTACCACTTCTTCCCTACCTATTCAGGTAATTTAAGTGTCAGAAACAAATTGCTCATCTGCCTGAGTTCTGTGTGCAGCCTAAAAATGTTCTCTCCTCTCTCATAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGTGTTCAGTATAAGACACCAAATATGTTCTTAAGAGTCCTTCCCTGAATCTTGTAATGGCTATTTGGCCAGATTGATAGTAGTTTGAATTAGAAATGAGGAGGTTTAAGTATAATTCCTGTGTTGACACTCTTGCTTTGTAGTTTAGGTCAAGTCACTATTAAAAATGAAACCATAATCTACTTGAACTTGCTGGAAATCTTGTTAAACGGTGCCTCAGATGTTAGTACTGTGCAAATATTTTAATAAAACATCTATATACAGGCCGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACAAGGTCAGGAGATCGAGAACATCCTGGCTAACACGGTGAATCCGTCTCTACTAAAAAAATACAAAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCCGGAGGCTGAAGCAGGAGAATGGAGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCAAGAATGCCCCACTGCACTCCAGCCTGGGCGACAGAGCTAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAATCTGTATACAGGAAAAACTATGAATATGAGATTTTAGGGTGGTAAGGAAGGGACCAGAATCTGACACAGGCTAGAAATAGGCTTCAGAGAATCCTTGTTTCCTGTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGGTAAGTTGTGGGATAGGGACAGAGAATGCCTACTTTCAGTGGCTGTGAATTCCAGGAGCCTTGCTAGGAGGCTAAGACATCAGTGCCTGAGATCATCAAGCTCTTAGGAAGAAGAGAGACATTAGTTATTCGTTATTTTGTGGGGGAAAGTGGTGGCAGCATTAAGGCTTTTGGAGTGTCTATGGCCACAAAATTGACATTTATCCTTTCCCCATCAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCACCCATGCATCAACAACCAGGTAAGGTGTTGATGGGATCAGTTCTTCTTTTCGGAATGTCATATTAACTGTGAAGACATGAAGATATAACATTTTCATTTAAGCCCTGTTAAAGCTACTGTTGTATAGACACTTAGGAACTCTTGCTAATCTAATTAACATGCTCTCGTTGGTATAGATGTTTTAGTTCATAAAAGAATTAAAAACCCACAAGTGTGGAAGAATGAATATGAGTAATTGATATGCCTCTCCCCTGTTATTTAAAAAATGTTTGGGCTGGGCACAGTGGCTCACACTGGTAATCCCAACACTTTGGGAGGCCAAGGTGATAGGATGGTTTGAGGCCAGGAATTCGACACTAGTAAGGGCAACAAAGTGAGGCCTCTGTCTCTACAAAAAAAAGTAGCTGGTGTGGTGGCGTGTGCCTGTAGTCTTAGCTACCCAGGAGACTGAGGCAGGAGGATCAGTTGAGCATAGGAATTCGAGGCTGTATTGAGCTATGATCACACATCACTGCACTCCAGCCTGGCAAAAGAGCAGGACACTGTCTTGAAAAAATTTTTTTTCTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACAGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCAACTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCCTAAATTTTTCTTTTTTTAATGTTTGTTTCAATATGGACAATCCACTGAGAGGGGCCAGGGCAAAAATGGATTCTGCCAGGTTGGAAATGCACTAAGGAAAACAGTACAGAAACATTCCCAGGGTCCTTCTAGGAAGAATATATGTCTAAAAAATTTTCAGCTCTGTTACAAAGTCAGGAACGGAATTGTTTAATTATAATAAATTGGTGCTTTGGTCTGTGTCTTTGGGTCAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTA
Task1_train_20535
Assess the clinical impact of this variant on gene RAD51 (RAD51 recombinase), found on Chromosome 15. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Inborn genetic diseases
TGGTGTGCAATGGTATGATCTCGACTCACTGCAACTTCTGTCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGACCAGGCTGGTCTCCGACTCCTGACATCAGGTGATCCACCTGCCTCGGCATCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGCACCTGGCCCTCAAAGAATAGGTTTGATTTAGGTCAGGCGTGGTGGCTCACGCCTGTAGTCCCAGTATTTTGGGAGGCCAAGGTGGGCGGATTATGAGATCAGGAGGTCAAGACCAGCCTGATCAATATGGTGAAACCCTGTCTCTACTAAAAATAAAAATATTAGCTATGCATGGTGCTGCATAGCTCCATGCTACTTTGGAGGCTGAGGCAGGAGAATCGCGTGAACCCAGGAGGTGGAGGTTGCAATGAGATCACGCCGCTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAGAAAAAAAAAAAAGAATGGATTTGATTTATCCCAAAGACTTGCCAGGTAGAGCTCCAGAGTAGTTGGGTGCTATCATCTCTCTGCTTATAGTTTGCCTGAACTTCTTAATAGAAAGGGAAATACATTCTTTGGTCCTGAAACTACTGTCAGTACCACTTCTTCCCTACCTATTCAGGTAATTTAAGTGTCAGAAACAAATTGCTCATCTGCCTGAGTTCTGTGTGCAGCCTAAAAATGTTCTCTCCTCTCTCATAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGTGTTCAGTATAAGACACCAAATATGTTCTTAAGAGTCCTTCCCTGAATCTTGTAATGGCTATTTGGCCAGATTGATAGTAGTTTGAATTAGAAATGAGGAGGTTTAAGTATAATTCCTGTGTTGACACTCTTGCTTTGTAGTTTAGGTCAAGTCACTATTAAAAATGAAACCATAATCTACTTGAACTTGCTGGAAATCTTGTTAAACGGTGCCTCAGATGTTAGTACTGTGCAAATATTTTAATAAAACATCTATATACAGGCCGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACAAGGTCAGGAGATCGAGAACATCCTGGCTAACACGGTGAATCCGTCTCTACTAAAAAAATACAAAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCCGGAGGCTGAAGCAGGAGAATGGAGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCAAGAATGCCCCACTGCACTCCAGCCTGGGCGACAGAGCTAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAATCTGTATACAGGAAAAACTATGAATATGAGATTTTAGGGTGGTAAGGAAGGGACCAGAATCTGACACAGGCTAGAAATAGGCTTCAGAGAATCCTTGTTTCCTGTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGGTAAGTTGTGGGATAGGGACAGAGAATGCCTACTTTCAGTGGCTGTGAATTCCAGGAGCCTTGCTAGGAGGCTAAGACATCAGTGCCTGAGATCATCAAGCTCTTAGGAAGAAGAGAGACATTAGTTATTCGTTATTTTGTGGGGGAAAGTGGTGGCAGCATTAAGGCTTTTGGAGTGTCTATGGCCACAAAATTGACATTTATCCTTTCCCCATCAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGGTAAGGTGTTGATGGGATCAGTTCTTCTTTTCGGAATGTCATATTAACTGTGAAGACATGAAGATATAACATTTTCATTTAAGCCCTGTTAAAGCTACTGTTGTATAGACACTTAGGAACTCTTGCTAATCTAATTAACATGCTCTCGTTGGTATAGATGTTTTAGTTCATAAAAGAATTAAAAACCCACAAGTGTGGAAGAATGAATATGAGTAATTGATATGCCTCTCCCCTGTTATTTAAAAAATGTTTGGGCTGGGCACAGTGGCTCACACTGGTAATCCCAACACTTTGGGAGGCCAAGGTGATAGGATGGTTTGAGGCCAGGAATTCGACACTAGTAAGGGCAACAAAGTGAGGCCTCTGTCTCTACAAAAAAAAGTAGCTGGTGTGGTGGCGTGTGCCTGTAGTCTTAGCTACCCAGGAGACTGAGGCAGGAGGATCAGTTGAGCATAGGAATTCGAGGCTGTATTGAGCTATGATCACACATCACTGCACTCCAGCCTGGCAAAAGAGCAGGACACTGTCTTGAAAAAATTTTTTTTCTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACAGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCAACTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCCTAAATTTTTCTTTTTTTAATGTTTGTTTCAATATGGACAATCCACTGAGAGGGGCCAGGGCAAAAATGGATTCTGCCAGGTTGGAAATGCACTAAGGAAAACAGTACAGAAACATTCCCAGGGTCCTTCTAGGAAGAATATATGTCTAAAAAATTTTCAGCTCTGTTACAAAGTCAGGAACGGAATTGTTTAATTATAATAAATTGGTGCTTTGGTCTGTGTCTTTGGGTCAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTA
TGGTGTGCAATGGTATGATCTCGACTCACTGCAACTTCTGTCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGACCAGGCTGGTCTCCGACTCCTGACATCAGGTGATCCACCTGCCTCGGCATCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGCACCTGGCCCTCAAAGAATAGGTTTGATTTAGGTCAGGCGTGGTGGCTCACGCCTGTAGTCCCAGTATTTTGGGAGGCCAAGGTGGGCGGATTATGAGATCAGGAGGTCAAGACCAGCCTGATCAATATGGTGAAACCCTGTCTCTACTAAAAATAAAAATATTAGCTATGCATGGTGCTGCATAGCTCCATGCTACTTTGGAGGCTGAGGCAGGAGAATCGCGTGAACCCAGGAGGTGGAGGTTGCAATGAGATCACGCCGCTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAGAAAAAAAAAAAAGAATGGATTTGATTTATCCCAAAGACTTGCCAGGTAGAGCTCCAGAGTAGTTGGGTGCTATCATCTCTCTGCTTATAGTTTGCCTGAACTTCTTAATAGAAAGGGAAATACATTCTTTGGTCCTGAAACTACTGTCAGTACCACTTCTTCCCTACCTATTCAGGTAATTTAAGTGTCAGAAACAAATTGCTCATCTGCCTGAGTTCTGTGTGCAGCCTAAAAATGTTCTCTCCTCTCTCATAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGTGTTCAGTATAAGACACCAAATATGTTCTTAAGAGTCCTTCCCTGAATCTTGTAATGGCTATTTGGCCAGATTGATAGTAGTTTGAATTAGAAATGAGGAGGTTTAAGTATAATTCCTGTGTTGACACTCTTGCTTTGTAGTTTAGGTCAAGTCACTATTAAAAATGAAACCATAATCTACTTGAACTTGCTGGAAATCTTGTTAAACGGTGCCTCAGATGTTAGTACTGTGCAAATATTTTAATAAAACATCTATATACAGGCCGGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACAAGGTCAGGAGATCGAGAACATCCTGGCTAACACGGTGAATCCGTCTCTACTAAAAAAATACAAAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCCGGAGGCTGAAGCAGGAGAATGGAGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCAAGAATGCCCCACTGCACTCCAGCCTGGGCGACAGAGCTAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAATCTGTATACAGGAAAAACTATGAATATGAGATTTTAGGGTGGTAAGGAAGGGACCAGAATCTGACACAGGCTAGAAATAGGCTTCAGAGAATCCTTGTTTCCTGTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGGTAAGTTGTGGGATAGGGACAGAGAATGCCTACTTTCAGTGGCTGTGAATTCCAGGAGCCTTGCTAGGAGGCTAAGACATCAGTGCCTGAGATCATCAAGCTCTTAGGAAGAAGAGAGACATTAGTTATTCGTTATTTTGTGGGGGAAAGTGGTGGCAGCATTAAGGCTTTTGGAGTGTCTATGGCCACAAAATTGACATTTATCCTTTCCCCATCAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCACCCATGCATCAACAACCAGGTAAGGTGTTGATGGGATCAGTTCTTCTTTTCGGAATGTCATATTAACTGTGAAGACATGAAGATATAACATTTTCATTTAAGCCCTGTTAAAGCTACTGTTGTATAGACACTTAGGAACTCTTGCTAATCTAATTAACATGCTCTCGTTGGTATAGATGTTTTAGTTCATAAAAGAATTAAAAACCCACAAGTGTGGAAGAATGAATATGAGTAATTGATATGCCTCTCCCCTGTTATTTAAAAAATGTTTGGGCTGGGCACAGTGGCTCACACTGGTAATCCCAACACTTTGGGAGGCCAAGGTGATAGGATGGTTTGAGGCCAGGAATTCGACACTAGTAAGGGCAACAAAGTGAGGCCTCTGTCTCTACAAAAAAAAGTAGCTGGTGTGGTGGCGTGTGCCTGTAGTCTTAGCTACCCAGGAGACTGAGGCAGGAGGATCAGTTGAGCATAGGAATTCGAGGCTGTATTGAGCTATGATCACACATCACTGCACTCCAGCCTGGCAAAAGAGCAGGACACTGTCTTGAAAAAATTTTTTTTCTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACAGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCCAACTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCCTAAATTTTTCTTTTTTTAATGTTTGTTTCAATATGGACAATCCACTGAGAGGGGCCAGGGCAAAAATGGATTCTGCCAGGTTGGAAATGCACTAAGGAAAACAGTACAGAAACATTCCCAGGGTCCTTCTAGGAAGAATATATGTCTAAAAAATTTTCAGCTCTGTTACAAAGTCAGGAACGGAATTGTTTAATTATAATAAATTGGTGCTTTGGTCTGTGTCTTTGGGTCAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTA
Task1_train_20536
Given this context: Chromosome 15, gene ZFYVE19 (zinc finger FYVE-type containing 19) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Cholestasis, progressive familial intrahepatic, 9
GTTGCAGTAAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCCACAGAGCGAGACTCCGTCTCAAAAACAATAATAAAAAATAATAATAATAAAGAATTTAAAAAATAATAATTTGTAAACATAGAGCACTTAGAATACTATCCAGAAAAAAAAAATACTGTCTAGGACATAGTAAGCATTATACAGATGTTAGGAATTATTAATCCTAAAATATTGAAACACGAGAGAGGTGGAGCAGATGCTTTTGATGCTTCATAGACATCCCATGGCCATTTCTGATTTCAGCTGCGGCTGCAGGGGACAGATTTGTGCAGGTTGACAGCATTTCTCAAGGGCCCTCTGGGTCTCTCTGATTTTCTGCCCCAGAGCTTCCTCTTCTCAAAAGCTCACTCACCCCATGAGCAGGGCAGCCCAGAAGTACTGGGACATTAGTGGGCACTATTTTTTTTTCCTTTTTTTTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGACTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCGCCTCCCGGGTTCCAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGTGTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGAAGGGGTTTCAGCATATTGGTCAGGCTGGTCTCGAACTTCTGACCACATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCGGCCTAGTAGACACTAATTTTCTTTCTTTCTTTCTTTTTTTGAGAAAGAGTCTTGCTCTGTCGCCCAGGATGGAGTGCAGTGGCGCGATCTCGGCTCAGTTGGGCACTAATTTTCATTTGATGAACGCCTCTCCTTCGTATATTGTTAAAACTACCACCATGATCCAGGGGGAGATAAAAGAAATCCTAAATCCAGCTTGATCAGTGTTTCACTCCCTGGCATCTTTATCACCACCTAAGGTAGCATGGACCTCTATACCATCTGCCTTAACCTTCTGATCCTCCTGCTTTTAGCCCACTAACTAGCACATGCTGAGAAGGGCATCAGCTACTTGAAAAGAGTCAATGGGCTTGAGTGGAAAAGAAAATAGAGACAGCAGGGTCATCGGTCACATTGGCAAGGGGGCATGAAAAGGGAGTGGAGAGGCTTTGAGATCTTACTTTTCTTTCGTTCTAGGCTCTTAGTGGAAGAATTAAATCAGCCTGCAGAAGAGACTGAAATGAGGCACCTCTTGTCACAGTCAAGGCAGAAGCGGAAACGGAGGCCGAGACTGCGCAGGCGCAGAGGAGGCTAGCGTTCCTTGCTGCCTCGCCCCGCGGCCTCTAGGAGACAGGGGCCACGGGGAGAGCACAGCCACCCGGCGCGAAGAGCCCTCTGTACCCCGCTTCCTCTTGAGGCCCTCGGACCGTCCAGGAAATGTCTGGGAGCCCGCCTGCGGAGGGCATAGCGCCGACCCTCGCTCCCCGCCCAGGACCCGAATGAACCTGGAGAGCGGATGCCAGCAGTGGCCGAGGCGCTAGGACAGGAAGGACCGCCAGACCTCTCAAGATCAGCCTTCCTCGCCACCGTTCTCACCTCTTTGTCCGCTGCCTTCTCCTCAATGCCTAGCAGCGCGTACAGGTCCATCTGTAAGAGCTCCTTGGTCACTGCCATGGTTCCGGCCTGACGGATTCGTACTACAACTCCCAAGAGTCTAAGCGCGCGTGAGGACTGCAGGCTCCGAGCGGCGCCTAGCCCTCTGGGAATTGTGTTCTGGGTCAGGCTTGACTGACTCTGAGGGAGGCCGGCAGTCGTGAATGAACTACGACTCCCAGCAGCCCCCGTTGCCGCCGCTGCCGTACGCTGGCTGCAGGAGAGCGTCCGGATTCCCTGCTCTAGGTCGCGGCGGGACAGTGCCAGTGGGCGTGTGGGGCGGGGCAGGGCAGGGAAGGGAAGGGCGGAGCTGGGGTGAGGGTCCAAGGGGCCCAGGACTTGGCCGGCGTGATCTCAGCTCTGCAGACCCTGCGGTGCTGGGAGCCACCATGGAGAGTAGGTGCTACGGCTGCGCTGTCAAGTTCACCCTCTTCAAGAAGGAGGCGAGTCTTCCCTCCCCGAGGGCTGCAGGGCCAGGGAGGAGAGGAGGGAAAAGCGCGGGACTTAACGTCCAAAGACTTGGTCTTACGGCTCCTTTCCAGCTGTGTGGTTTTGATGAAGTCATTGATCCTCAGTTTCCATTTCTGTAAAATGGGGCTAACATTCTCTCGCTTTCAGGGTTTATGTGAGGGTCCACTGAAGTGCTTTAGGTGAGAGTTCCCTATAAACTGTAAAGCGCGCTGCCGTCGTTTTTGCAAAGCTACTCTTTTCTGTCGGCCCAGTGTAGCATCTGGCGGTTTTCTTCTCTCCACCCTGCTCCTCCGAAGCGCGGTGTCCATCACACCAAGCCCGTTACTCCCTCTGCTCTGAAATCTTCCCCATCCCGCAGCCTGCCCTTCTCCAGGTCGCTGGAGTTAGATTACCACACTTCCTCCTGCTTCCGGGGCACCATGGTGAAGGCTGACTGTCCTGTCCCTATCACAGACCTGCCAGATTCCTCTGGTAAACTGCAGGTTCCCTCTGCCTCAGTTGTGGCCAGGGATTCTGACCAGGAGATGATGGGAACTAGATGGAGTAAATTAGTGTCACGCAGGAAGGCAGGACCGTGCAGCATTCACCAACCTGGATTTTGGAGTCAGCGTTCAAATCTGAGCTCTGCTGTCTTATTGAGGCGGTGACCTTGGTTTGGATAAGTTATGTAACCTCTCTGGCCCTCTCAAAATAAGGATAATCACGGTTGGCATCAAGATTAAGTAAAATAATGTGTGTAAATTGTAAGGAATAAATCACATGATGAATGTTAAGTACTGGGTTTAGTGCCTGGCACATAGTAAGTGCTTAATAAATGGAGGCTATTGTTAGCCCATCCTGAGCCAAGCCTCCCTCCATCTCTGCAAGAGCAGAGGAGGCATCGGCTCTGCCCTGTCTCTCTGATTCTCCTTTGTGGAAGAGTCAGTGGCCTGAAATACTGGGCTTTATCTATCTGTCTTCTACATCCCTGGGTCAGGGAATTGAAGACAGGGTAGAAAGCATGGGAATTTTGTATAAACCTTCATTTGGCTTGAATAAGGTACTGGAAACCGAGGAATTGCTTTACTCACCATCCCTAGGCCTTAGGGGCCCCACTCCTCTTCTTCCTCCCAGCAGCTGGTCATAACTTCAGTGACTTCTCTCTGTGTGTGCTTGGAGAGTCCCTGGGAGCAGCCTGCAGGGGCGGGTGAGAGGGGGATCTCCCGCTTCATGTTTCTTGTAGTACGGCTGTAAGAATTGTGGCAGGGCCTTCTGTTCAGGCTGCCTAAGCTTCAGTGCAGCAGTGCCTCGGACTGGGAACACCCAACAGAAAGTCTGCAAGCAATGCCATGAGGTCCTGACCAGGTAAGAGGCAGGCATGGGTGAAAGTTCAGCCAAGTATGGCAGTGGGCATCTGGCCAGCCCTCACAGCTTTGTACTCTGTCGCGAGAGTCAGCCGAGGAAGTGTTTGGAGTGGGGGGCACTGCCTGGTGGGATGGCAGGATTTATAACACTAGATTTCTTCTCTGTAGAGGGTCTTCTGCCAATGCCTCCAAGTGGTCACCACCTCAGAACTATAAGAAGTAAGTGCTGAAGAGAAAAAGACAAAGAGCATTGGGGAAAGGATAAGGGAGCCATAGGGAAAGACCCTGCCCCCATCTTCTAGATAAAATGAGCACAGAATCAGGAGAATTCTCTCCTCTCTGGCTCCTGACTGCCCTCTTGGGCTGGTAAAGCAGCTCTTCAGCCCTCTCTCCAGGACAGGCACTTGGTAGAGCTTGTCCTTTCAGCTGGACCGTCTGGCTGGTCAGCCAGGTTGGGCTGCAGGGTGACATGAGTGAGGGGCACAGCAGATTGCCCATTGGAGGCCTCCCTAAGTGCCCAGAAATGATTTGATTTGAATGGGAAACAGTGAGTGGGTGCCTTCACTCTTCCCCTCTGCCTTCTTCAAGAGCCTCTATCTCATATCCTGCCAGGCGTGTGGCAG
GTTGCAGTAAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCCACAGAGCGAGACTCCGTCTCAAAAACAATAATAAAAAATAATAATAATAAAGAATTTAAAAAATAATAATTTGTAAACATAGAGCACTTAGAATACTATCCAGAAAAAAAAAATACTGTCTAGGACATAGTAAGCATTATACAGATGTTAGGAATTATTAATCCTAAAATATTGAAACACGAGAGAGGTGGAGCAGATGCTTTTGATGCTTCATAGACATCCCATGGCCATTTCTGATTTCAGCTGCGGCTGCAGGGGACAGATTTGTGCAGGTTGACAGCATTTCTCAAGGGCCCTCTGGGTCTCTCTGATTTTCTGCCCCAGAGCTTCCTCTTCTCAAAAGCTCACTCACCCCATGAGCAGGGCAGCCCAGAAGTACTGGGACATTAGTGGGCACTATTTTTTTTTCCTTTTTTTTTTTTTTTTTTGAGACAGTCTCGCTCTGTCGCCCAGACTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCGCCTCCCGGGTTCCAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGTGTGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGAAGGGGTTTCAGCATATTGGTCAGGCTGGTCTCGAACTTCTGACCACATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCGGCCTAGTAGACACTAATTTTCTTTCTTTCTTTCTTTTTTTGAGAAAGAGTCTTGCTCTGTCGCCCAGGATGGAGTGCAGTGGCGCGATCTCGGCTCAGTTGGGCACTAATTTTCATTTGATGAACGCCTCTCCTTCGTATATTGTTAAAACTACCACCATGATCCAGGGGGAGATAAAAGAAATCCTAAATCCAGCTTGATCAGTGTTTCACTCCCTGGCATCTTTATCACCACCTAAGGTAGCATGGACCTCTATACCATCTGCCTTAACCTTCTGATCCTCCTGCTTTTAGCCCACTAACTAGCACATGCTGAGAAGGGCATCAGCTACTTGAAAAGAGTCAATGGGCTTGAGTGGAAAAGAAAATAGAGACAGCAGGGTCATCGGTCACATTGGCAAGGGGGCATGAAAAGGGAGTGGAGAGGCTTTGAGATCTTACTTTTCTTTCGTTCTAGGCTCTTAGTGGAAGAATTAAATCAGCCTGCAGAAGAGACTGAAATGAGGCACCTCTTGTCACAGTCAAGGCAGAAGCGGAAACGGAGGCCGAGACTGCGCAGGCGCAGAGGAGGCTAGCGTTCCTTGCTGCCTCGCCCCGCGGCCTCTAGGAGACAGGGGCCACGGGGAGAGCACAGCCACCCGGCGCGAAGAGCCCTCTGTACCCCGCTTCCTCTTGAGGCCCTCGGACCGTCCAGGAAATGTCTGGGAGCCCGCCTGCGGAGGGCATAGCGCCGACCCTCGCTCCCCGCCCAGGACCCGAATGAACCTGGAGAGCGGATGCCAGCAGTGGCCGAGGCGCTAGGACAGGAAGGACCGCCAGACCTCTCAAGATCAGCCTTCCTCGCCACCGTTCTCACCTCTTTGTCCGCTGCCTTCTCCTCAATGCCTAGCAGCGCGTACAGGTCCATCTGTAAGAGCTCCTTGGTCACTGCCATGGTTCCGGCCTGACGGATTCGTACTACAACTCCCAAGAGTCTAAGCGCGCGTGAGGACTGCAGGCTCCGAGCGGCGCCTAGCCCTCTGGGAATTGTGTTCTGGGTCAGGCTTGACTGACTCTGAGGGAGGCCGGCAGTCGTGAATGAACTACGACTCCCAGCAGCCCCCGTTGCCGCCGCTGCCGTACGCTGGCTGCAGGAGAGCGTCCGGATTCCCTGCTCTAGGTCGCGGCGGGACAGTGCCAGTGGGCGTGTGGGGCGGGGCAGGGCAGGGAAGGGAAGGGCGGAGCTGGGGTGAGGGTCCAAGGGGCCCAGGACTTGGCCGGCGTGATCTCAGCTCTGCAGACCCTGCGGTGCTGGGAGCCACCGTGGAGAGTAGGTGCTACGGCTGCGCTGTCAAGTTCACCCTCTTCAAGAAGGAGGCGAGTCTTCCCTCCCCGAGGGCTGCAGGGCCAGGGAGGAGAGGAGGGAAAAGCGCGGGACTTAACGTCCAAAGACTTGGTCTTACGGCTCCTTTCCAGCTGTGTGGTTTTGATGAAGTCATTGATCCTCAGTTTCCATTTCTGTAAAATGGGGCTAACATTCTCTCGCTTTCAGGGTTTATGTGAGGGTCCACTGAAGTGCTTTAGGTGAGAGTTCCCTATAAACTGTAAAGCGCGCTGCCGTCGTTTTTGCAAAGCTACTCTTTTCTGTCGGCCCAGTGTAGCATCTGGCGGTTTTCTTCTCTCCACCCTGCTCCTCCGAAGCGCGGTGTCCATCACACCAAGCCCGTTACTCCCTCTGCTCTGAAATCTTCCCCATCCCGCAGCCTGCCCTTCTCCAGGTCGCTGGAGTTAGATTACCACACTTCCTCCTGCTTCCGGGGCACCATGGTGAAGGCTGACTGTCCTGTCCCTATCACAGACCTGCCAGATTCCTCTGGTAAACTGCAGGTTCCCTCTGCCTCAGTTGTGGCCAGGGATTCTGACCAGGAGATGATGGGAACTAGATGGAGTAAATTAGTGTCACGCAGGAAGGCAGGACCGTGCAGCATTCACCAACCTGGATTTTGGAGTCAGCGTTCAAATCTGAGCTCTGCTGTCTTATTGAGGCGGTGACCTTGGTTTGGATAAGTTATGTAACCTCTCTGGCCCTCTCAAAATAAGGATAATCACGGTTGGCATCAAGATTAAGTAAAATAATGTGTGTAAATTGTAAGGAATAAATCACATGATGAATGTTAAGTACTGGGTTTAGTGCCTGGCACATAGTAAGTGCTTAATAAATGGAGGCTATTGTTAGCCCATCCTGAGCCAAGCCTCCCTCCATCTCTGCAAGAGCAGAGGAGGCATCGGCTCTGCCCTGTCTCTCTGATTCTCCTTTGTGGAAGAGTCAGTGGCCTGAAATACTGGGCTTTATCTATCTGTCTTCTACATCCCTGGGTCAGGGAATTGAAGACAGGGTAGAAAGCATGGGAATTTTGTATAAACCTTCATTTGGCTTGAATAAGGTACTGGAAACCGAGGAATTGCTTTACTCACCATCCCTAGGCCTTAGGGGCCCCACTCCTCTTCTTCCTCCCAGCAGCTGGTCATAACTTCAGTGACTTCTCTCTGTGTGTGCTTGGAGAGTCCCTGGGAGCAGCCTGCAGGGGCGGGTGAGAGGGGGATCTCCCGCTTCATGTTTCTTGTAGTACGGCTGTAAGAATTGTGGCAGGGCCTTCTGTTCAGGCTGCCTAAGCTTCAGTGCAGCAGTGCCTCGGACTGGGAACACCCAACAGAAAGTCTGCAAGCAATGCCATGAGGTCCTGACCAGGTAAGAGGCAGGCATGGGTGAAAGTTCAGCCAAGTATGGCAGTGGGCATCTGGCCAGCCCTCACAGCTTTGTACTCTGTCGCGAGAGTCAGCCGAGGAAGTGTTTGGAGTGGGGGGCACTGCCTGGTGGGATGGCAGGATTTATAACACTAGATTTCTTCTCTGTAGAGGGTCTTCTGCCAATGCCTCCAAGTGGTCACCACCTCAGAACTATAAGAAGTAAGTGCTGAAGAGAAAAAGACAAAGAGCATTGGGGAAAGGATAAGGGAGCCATAGGGAAAGACCCTGCCCCCATCTTCTAGATAAAATGAGCACAGAATCAGGAGAATTCTCTCCTCTCTGGCTCCTGACTGCCCTCTTGGGCTGGTAAAGCAGCTCTTCAGCCCTCTCTCCAGGACAGGCACTTGGTAGAGCTTGTCCTTTCAGCTGGACCGTCTGGCTGGTCAGCCAGGTTGGGCTGCAGGGTGACATGAGTGAGGGGCACAGCAGATTGCCCATTGGAGGCCTCCCTAAGTGCCCAGAAATGATTTGATTTGAATGGGAAACAGTGAGTGGGTGCCTTCACTCTTCCCCTCTGCCTTCTTCAAGAGCCTCTATCTCATATCCTGCCAGGCGTGTGGCAG
Task1_train_20537
A mutation found in DLL4 (delta like canonical Notch ligand 4) on Chromosome 15 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Adams-Oliver syndrome
CAAGCCCTGGCAGGGGGCAGAAGGGAGAAGGCACGCGCTGGGCACGCCCCCCCTTAGCTAGAGAGGGAGACGCCCAACAGGTGCACAGAGAGGGCCCCGAGCCTTAGACCCTTAGCCCCTAGCCTTGCTCAGAGTGGCCACAGAGAGGTTAACGCTTCTGCTGGCTTCCCTGCTGCGCTGGGGACGCGTGGTGGGTGGGCACTCATAGGTTGGGGGCCGTTGAGACAAGGGCTCCAGAAGCTCCAGGAAGGAAAAGGAGATCGGATTTCCCTAGCGCTGGTTTTTGCATTCCGGGCTTAAGTTCTTTTTACCTGCTTTGGAACACTAGGTAACTAGCGCCTGCTGCGGATGCACAGCCTACAGGGACTGCCTAGTGTCTCCGCCCCCAAGACCATCCCCGAACCACCCACTCACCTCCTGCCCCATTACCGGGCAACCCCTCTATCCTCCGGCGGCCAGGGTCTCAGCCCTTAACCCCGCCATCACGGAGGACTGGTCACCTCGGCACGCGCAGAGCTGGGGGACCTAGAGGTTGGGAGCGGCACGGAGGGGCGGGGACCTGCGCCCGACTGGCTGACGGGGAGGGGGGAGCGGCGGGGGCGGAGGCCCCCTCCGGGCGGCGCTGGGACTGTAGCAGCTAGAGGCCGGGAGGGGAGGGGAGAATGACCATGAGTCTGAGTGACAGGCGGCGAGGAGAGGAGCCAATATATATAAGGAAGGCCCCCAGCGCGCAGGTTTCAGTAGCGGCGCTGCGCGCAGGCCGGGAACACGAGGCCAAGAGCCGCAGCCCCAGCCGCCTTGGTGCAGCGTACACCGGCACTAGCCCGCTTGCAGCCCCAGGATTAGACAGAAGACGCGTCCTCGGCGCGGTCGCCGCCCAGCCGTAGTCACCTGGATTACCTACAGCGGCAGCTGCAGCGGAGCCAGCGAGAAGGCCAAAGGGGAGCAGCGTCCCGAGAGGAGCGCCTCTTTTCAGGGACCCCGCCGGCTGGCGGACGCGCGGGAAAGCGGCGTCGCGAACAGAGCCAGATTGAGGGCCCGCGGGTGGAGAGAGCGACGCCCGAGGGGATGGCGGCAGCGTCCCGGAGCGCCTCTGGCTGGGCGCTACTGCTGCTGGTGGCACTTTGGCAGCAGGTAACACGTCCCGCGCCCTCTCCGTCCCCTCTGCCGCGCTCTGGGCCTCAGCCCCGGGCACCAGCTGAGCTGACCGGTCCCCTCCCTCCTTCCCTCGGTCCCTGTGCAATAGCGCGCGGCCGGCTCCGGCGTCTTCCAGCTGCAGCTGCAGGAGTTCATCAACGAGCGCGGCGTACTGGCCAGTGGGCGGCCTTGCGAGCCCGGCTGCCGGACTTTCTTCCGCGTCTGCCTTAAGCACTTCCAGGCGGTCGTCTCGCCCGGACCCTGCACCTTCGGGACCGTCTCCACGCCGGTATTGGGCACCAACTCCTTCGCTGTCCGGGACGACAGTAGCGGCGGGGGGCGCAACCCTCTCCAACTGCCCTTCAATTTCACCTGGCCGGTGAGCACAGCCTGGGCGCACTGGGAGGTCGCAGAAGCCGAGAGAGGAGGCGCCCTGGGACCAAAGCCCCCTCCCCAGATTTCCTTGTACACACACCCCCACCCCCAAAAAGCCCAGGATGCATTCTTTCCTGGCTCTTCCCGACTCTCTCCTGAGACTGATCCCAGAAAAGGCTCTCACCAGTCTCCGTCTTCCCAGTTTATGTCCTCCCGTCCCCAGCTCTTGGGACACGATTTTCATTACCTACCACTCTGGGGCGGTACCCTACCACCCCCTCCTCCAGTGGCTCTCCCTTACACTCTCCCGTCTCTCAACCCTCCCTCTACCGGGGGTTCTCCTCTCGCCTTCCCTGCTCAAGCGCTACACTGTGCACAGCCCCGTTATGTTGACCCGGGCGCAGTAACTGAATCCTGCAATTAGATTAATTAAACAGGCTGCCGCAAGGCACCCCCACCTCTCCCCGCTTGCTCATCTCGCCATCTCTCCGTCCCCCCACCCCCTTTCCCAGGGTACCTTCTCGCTCATCATCGAAGCTTGGCACGCGCCAGGAGACGACCTGCGGCCAGGTGAGTAGCTCGCTCCGCCACCACAGGGGGGCGACACGGCGCAGCGCCGAAAGAGTTAATCTGTTCTAGGCGGGGGAAGTGCGGGCTTGGGGGTGGGAGGCAGGACGCTTAGCTTGGCCTGGAGCTGCGCCCCGCGCTGGACGCTCGGATTCCGCTCGCTGCCTGGACTCAGAGCACAATTGCGTTTCCTGCGGGTTATTTTTGGCGTGGGAACGCGGGGAGTACGGCGGTGAGAAAGGCTGAAGCTGCCAGCGCCGCTGACGGGCCCCTTCCTGTATTTTACACCTTTCGCGAATTCCGCTCCTTTGGAAAGGGAATAATGGCTTTGGGATGTTGTTCTGACACAGAGGAAAAGGATATTTCAGCAGCACAACAATTCTCACTTTGAAAAGGAAAAAAGAAAACCATTACCCACCTCTGGAGGCAGAACCCCTGAATGGGCACCAAAGGACCCCCTGCTCCCAGGGTCCTCTCTAGCCTGGGGAGCTTTTCTTTCTTTTTCTCTTTTTTCCATTTTGACCTCTTTTCCTCTTTCCCCTCCCTATCTGCCTCCAAGACCCTGGGATATCTTAACATCCTTCTATTGTCCCCTTTTTGAATACTATCAGGCCCCCTGCACATGCACACACGTAGGGCAGCTACGTAGCGGGGCTTTGGGTCCCTCTGGCCTGTTCTTGCTGGCAGGCGGGGGTCATCTGGATAACTGGGCTGATTGGTTGGCTGATCACCATCATCACAGCCAAGAAGGACATTGGCCAGCCGTCACTGGCACCCTTGGGGACTGGCGACCCTTCCCTGACCCGACCCTCTGCCCCCTCAGAGGCCTTGCCACCAGATGCACTCATCAGCAAGATCGCCATCCAGGGCTCCCTAGCTGTGGGTCAGAACTGGTTATTGGATGAGCAAACCAGCACCCTCACAAGGCTGCGCTACTCTTACCGGGTCATCTGCAGTGACAACTACTATGGAGACAACTGCTCCCGCCTGTGCAAGAAGCGCAATGACCACTTCGGCCACTATGTGTGCCAGCCAGATGGCAACTTGTCCTGCCTGCCCGGTTGGACTGGGGAATATTGCCAACAGCGTAAGCAGTCAAGCTCCCACCTGTGTGGAAGGGGAGGGTCCCCTGAGGAAACACAGTGGAGCTTCTTGGTCACAGCTTGCCTCCCTTGAAGAGTGGGTCTGGGCCTCCTACTAGCTGGGCCTCAGGGATGCTGAGGGTGGGCTTGACCTCAGACCTCCTGTCTCTTCCCAGTGCTCCTCCCATCATGCCAAAGCCCACAAGAACCCCATCATGACATTCCATCCAGTTTGGCTTCTCCTTCCCTGTGCCATTATTTCACTTTAAGACACTCGGGGCTCCTCTGGGAGGCCAGGAGTAGGAAGAGGGCCCAGGAGAGCTAGGGGATCCCCAGGGCCAGCAGGTGAGAATGGGGCTTAAGAGTCCTTGGTATCCCAGCCTCACCCAGCTCTGTGTTCTTCCCTTAGCTATCTGTCTTTCGGGCTGTCATGAACAGAATGGCTACTGCAGCAAGCCAGCAGAGTGCCTGTGAGTAGGGGACAGGAAGTGGTGAGTGGGAGCCCTCCCTTGGCCAAGGCCTCTCACCTCACTCTGCCTCTCTCTTGTTCCCCAGCTGCCGCCCAGGCTGGCAGGGCCGGCTGTGTAACGAATGCATCCCCCACAATGGCTGTCGCCACGGCACCTGCAGCACTCCCTGGCAATGTACTTGTGATGAGGGCTGGGGAGGCCTGTTTTGTGACCAAGGTGAGTCAGGGTGAAGAGAGGGTGCAGAGGGTGCAAGAGATATGGGGCTGGGGGGTGGAAATCCGATTCGTCACCTGGATCCTTCTTACTTGGTGACTGCAGACTTGGCTTTCCCATGATCTTCCAAGGATCTTGGGTCTTTTAAGGATCTTTACAACTGGCCCAGAATGAGGCGGTGGGTCCTTCTCCAGGTGCGGCGGCAGGGGGTGGTGGAGCCAGGGTGGCTGAAAAACCCAGGGGGGTGACAAG
CAAGCCCTGGCAGGGGGCAGAAGGGAGAAGGCACGCGCTGGGCACGCCCCCCCTTAGCTAGAGAGGGAGACGCCCAACAGGTGCACAGAGAGGGCCCCGAGCCTTAGACCCTTAGCCCCTAGCCTTGCTCAGAGTGGCCACAGAGAGGTTAACGCTTCTGCTGGCTTCCCTGCTGCGCTGGGGACGCGTGGTGGGTGGGCACTCATAGGTTGGGGGCCGTTGAGACAAGGGCTCCAGAAGCTCCAGGAAGGAAAAGGAGATCGGATTTCCCTAGCGCTGGTTTTTGCATTCCGGGCTTAAGTTCTTTTTACCTGCTTTGGAACACTAGGTAACTAGCGCCTGCTGCGGATGCACAGCCTACAGGGACTGCCTAGTGTCTCCGCCCCCAAGACCATCCCCGAACCACCCACTCACCTCCTGCCCCATTACCGGGCAACCCCTCTATCCTCCGGCGGCCAGGGTCTCAGCCCTTAACCCCGCCATCACGGAGGACTGGTCACCTCGGCACGCGCAGAGCTGGGGGACCTAGAGGTTGGGAGCGGCACGGAGGGGCGGGGACCTGCGCCCGACTGGCTGACGGGGAGGGGGGAGCGGCGGGGGCGGAGGCCCCCTCCGGGCGGCGCTGGGACTGTAGCAGCTAGAGGCCGGGAGGGGAGGGGAGAATGACCATGAGTCTGAGTGACAGGCGGCGAGGAGAGGAGCCAATATATATAAGGAAGGCCCCCAGCGCGCAGGTTTCAGTAGCGGCGCTGCGCGCAGGCCGGGAACACGAGGCCAAGAGCCGCAGCCCCAGCCGCCTTGGTGCAGCGTACACCGGCACTAGCCCGCTTGCAGCCCCAGGATTAGACAGAAGACGCGTCCTCGGCGCGGTCGCCGCCCAGCCGTAGTCACCTGGATTACCTACAGCGGCAGCTGCAGCGGAGCCAGCGAGAAGGCCAAAGGGGAGCAGCGTCCCGAGAGGAGCGCCTCTTTTCAGGGACCCCGCCGGCTGGCGGACGCGCGGGAAAGCGGCGTCGCGAACAGAGCCAGATTGAGGGCCCGCGGGTGGAGAGAGCGACGCCCGAGGGGATGGCGGCAGCGTCCCGGAGCGCCTCTGGCTGGGCGCTACTGCTGCTGGTGGCACTTTGGCAGCAGGTAACACGTCCCGCGCCCTCTCCGTCCCCTCTGCCGCGCTCTGGGCCTCAGCCCCGGGCACCAGCTGAGCTGACCGGTCCCCTCCCTCCTTCCCTCGGTCCCTGTGCAATAGCGCGCGGCCGGCTCCGGCGTCTTCCAGCTGCAGCTGCAGGAGTTCATCAACGAGCGCGGCGTACTGGCCAGTGGGCGGCCTTGCGAGCCCGGCTGCCGGACTTTCTTCCGCGTCTGCCTTAAGCACTTCCAGGCGGTCGTCTCGCCCGGACCCTGCACCTTCGGGACCGTCTCCACGCCGGTATTGGGCACCAACTCCTTCGCTGTCCGGGACGACAGTAGCGGCGGGGGGCGCAACCCTCTCCAACTGCCCTTCAATTTCACCTGGCCGGTGAGCACAGCCTGGGCGCACTGGGAGGTCGCAGAAGCCGAGAGAGGAGGCGCCCTGGGACCAAAGCCCCCTCCCCAGATTTCCTTGTACACACACCCCCACCCCCAAAAAGCCCAGGATGCATTCTTTCCTGGCTCTTCCCGACTCTCTCCTGAGACTGATCCCAGAAAAGGCTCTCACCAGTCTCCGTCTTCCCAGTTTATGTCCTCCCGTCCCCAGCTCTTGGGACACGATTTTCATTACCTACCACTCTGGGGCGGTACCCTACCACCCCCTCCTCCAGTGGCTCTCCCTTACACTCTCCCGTCTCTCAACCCTCCCTCTACCGGGGGTTCTCCTCTCGCCTTCCCTGCTCAAGCGCTACACTGTGCACAGCCCCGTTATGTTGACCCGGGCGCAGTAACTGAATCCTGCAATTAGATTAATTAAACAGGCTGCCGCAAGGCACCCCCACCTCTCCCCGCTTGCTCATCTCGCCATCTCTCCGTCCCCCCACCCCCTTTCCCAGGGTACCTTCTCGCTCATCATCGAACCTTGGCACGCGCCAGGAGACGACCTGCGGCCAGGTGAGTAGCTCGCTCCGCCACCACAGGGGGGCGACACGGCGCAGCGCCGAAAGAGTTAATCTGTTCTAGGCGGGGGAAGTGCGGGCTTGGGGGTGGGAGGCAGGACGCTTAGCTTGGCCTGGAGCTGCGCCCCGCGCTGGACGCTCGGATTCCGCTCGCTGCCTGGACTCAGAGCACAATTGCGTTTCCTGCGGGTTATTTTTGGCGTGGGAACGCGGGGAGTACGGCGGTGAGAAAGGCTGAAGCTGCCAGCGCCGCTGACGGGCCCCTTCCTGTATTTTACACCTTTCGCGAATTCCGCTCCTTTGGAAAGGGAATAATGGCTTTGGGATGTTGTTCTGACACAGAGGAAAAGGATATTTCAGCAGCACAACAATTCTCACTTTGAAAAGGAAAAAAGAAAACCATTACCCACCTCTGGAGGCAGAACCCCTGAATGGGCACCAAAGGACCCCCTGCTCCCAGGGTCCTCTCTAGCCTGGGGAGCTTTTCTTTCTTTTTCTCTTTTTTCCATTTTGACCTCTTTTCCTCTTTCCCCTCCCTATCTGCCTCCAAGACCCTGGGATATCTTAACATCCTTCTATTGTCCCCTTTTTGAATACTATCAGGCCCCCTGCACATGCACACACGTAGGGCAGCTACGTAGCGGGGCTTTGGGTCCCTCTGGCCTGTTCTTGCTGGCAGGCGGGGGTCATCTGGATAACTGGGCTGATTGGTTGGCTGATCACCATCATCACAGCCAAGAAGGACATTGGCCAGCCGTCACTGGCACCCTTGGGGACTGGCGACCCTTCCCTGACCCGACCCTCTGCCCCCTCAGAGGCCTTGCCACCAGATGCACTCATCAGCAAGATCGCCATCCAGGGCTCCCTAGCTGTGGGTCAGAACTGGTTATTGGATGAGCAAACCAGCACCCTCACAAGGCTGCGCTACTCTTACCGGGTCATCTGCAGTGACAACTACTATGGAGACAACTGCTCCCGCCTGTGCAAGAAGCGCAATGACCACTTCGGCCACTATGTGTGCCAGCCAGATGGCAACTTGTCCTGCCTGCCCGGTTGGACTGGGGAATATTGCCAACAGCGTAAGCAGTCAAGCTCCCACCTGTGTGGAAGGGGAGGGTCCCCTGAGGAAACACAGTGGAGCTTCTTGGTCACAGCTTGCCTCCCTTGAAGAGTGGGTCTGGGCCTCCTACTAGCTGGGCCTCAGGGATGCTGAGGGTGGGCTTGACCTCAGACCTCCTGTCTCTTCCCAGTGCTCCTCCCATCATGCCAAAGCCCACAAGAACCCCATCATGACATTCCATCCAGTTTGGCTTCTCCTTCCCTGTGCCATTATTTCACTTTAAGACACTCGGGGCTCCTCTGGGAGGCCAGGAGTAGGAAGAGGGCCCAGGAGAGCTAGGGGATCCCCAGGGCCAGCAGGTGAGAATGGGGCTTAAGAGTCCTTGGTATCCCAGCCTCACCCAGCTCTGTGTTCTTCCCTTAGCTATCTGTCTTTCGGGCTGTCATGAACAGAATGGCTACTGCAGCAAGCCAGCAGAGTGCCTGTGAGTAGGGGACAGGAAGTGGTGAGTGGGAGCCCTCCCTTGGCCAAGGCCTCTCACCTCACTCTGCCTCTCTCTTGTTCCCCAGCTGCCGCCCAGGCTGGCAGGGCCGGCTGTGTAACGAATGCATCCCCCACAATGGCTGTCGCCACGGCACCTGCAGCACTCCCTGGCAATGTACTTGTGATGAGGGCTGGGGAGGCCTGTTTTGTGACCAAGGTGAGTCAGGGTGAAGAGAGGGTGCAGAGGGTGCAAGAGATATGGGGCTGGGGGGTGGAAATCCGATTCGTCACCTGGATCCTTCTTACTTGGTGACTGCAGACTTGGCTTTCCCATGATCTTCCAAGGATCTTGGGTCTTTTAAGGATCTTTACAACTGGCCCAGAATGAGGCGGTGGGTCCTTCTCCAGGTGCGGCGGCAGGGGGTGGTGGAGCCAGGGTGGCTGAAAAACCCAGGGGGGTGACAAG
Task1_train_20538
Located on Chromosome 15, this mutation impacts DLL4 (delta like canonical Notch ligand 4). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Adams-Oliver syndrome
GCGAACAGAGCCAGATTGAGGGCCCGCGGGTGGAGAGAGCGACGCCCGAGGGGATGGCGGCAGCGTCCCGGAGCGCCTCTGGCTGGGCGCTACTGCTGCTGGTGGCACTTTGGCAGCAGGTAACACGTCCCGCGCCCTCTCCGTCCCCTCTGCCGCGCTCTGGGCCTCAGCCCCGGGCACCAGCTGAGCTGACCGGTCCCCTCCCTCCTTCCCTCGGTCCCTGTGCAATAGCGCGCGGCCGGCTCCGGCGTCTTCCAGCTGCAGCTGCAGGAGTTCATCAACGAGCGCGGCGTACTGGCCAGTGGGCGGCCTTGCGAGCCCGGCTGCCGGACTTTCTTCCGCGTCTGCCTTAAGCACTTCCAGGCGGTCGTCTCGCCCGGACCCTGCACCTTCGGGACCGTCTCCACGCCGGTATTGGGCACCAACTCCTTCGCTGTCCGGGACGACAGTAGCGGCGGGGGGCGCAACCCTCTCCAACTGCCCTTCAATTTCACCTGGCCGGTGAGCACAGCCTGGGCGCACTGGGAGGTCGCAGAAGCCGAGAGAGGAGGCGCCCTGGGACCAAAGCCCCCTCCCCAGATTTCCTTGTACACACACCCCCACCCCCAAAAAGCCCAGGATGCATTCTTTCCTGGCTCTTCCCGACTCTCTCCTGAGACTGATCCCAGAAAAGGCTCTCACCAGTCTCCGTCTTCCCAGTTTATGTCCTCCCGTCCCCAGCTCTTGGGACACGATTTTCATTACCTACCACTCTGGGGCGGTACCCTACCACCCCCTCCTCCAGTGGCTCTCCCTTACACTCTCCCGTCTCTCAACCCTCCCTCTACCGGGGGTTCTCCTCTCGCCTTCCCTGCTCAAGCGCTACACTGTGCACAGCCCCGTTATGTTGACCCGGGCGCAGTAACTGAATCCTGCAATTAGATTAATTAAACAGGCTGCCGCAAGGCACCCCCACCTCTCCCCGCTTGCTCATCTCGCCATCTCTCCGTCCCCCCACCCCCTTTCCCAGGGTACCTTCTCGCTCATCATCGAAGCTTGGCACGCGCCAGGAGACGACCTGCGGCCAGGTGAGTAGCTCGCTCCGCCACCACAGGGGGGCGACACGGCGCAGCGCCGAAAGAGTTAATCTGTTCTAGGCGGGGGAAGTGCGGGCTTGGGGGTGGGAGGCAGGACGCTTAGCTTGGCCTGGAGCTGCGCCCCGCGCTGGACGCTCGGATTCCGCTCGCTGCCTGGACTCAGAGCACAATTGCGTTTCCTGCGGGTTATTTTTGGCGTGGGAACGCGGGGAGTACGGCGGTGAGAAAGGCTGAAGCTGCCAGCGCCGCTGACGGGCCCCTTCCTGTATTTTACACCTTTCGCGAATTCCGCTCCTTTGGAAAGGGAATAATGGCTTTGGGATGTTGTTCTGACACAGAGGAAAAGGATATTTCAGCAGCACAACAATTCTCACTTTGAAAAGGAAAAAAGAAAACCATTACCCACCTCTGGAGGCAGAACCCCTGAATGGGCACCAAAGGACCCCCTGCTCCCAGGGTCCTCTCTAGCCTGGGGAGCTTTTCTTTCTTTTTCTCTTTTTTCCATTTTGACCTCTTTTCCTCTTTCCCCTCCCTATCTGCCTCCAAGACCCTGGGATATCTTAACATCCTTCTATTGTCCCCTTTTTGAATACTATCAGGCCCCCTGCACATGCACACACGTAGGGCAGCTACGTAGCGGGGCTTTGGGTCCCTCTGGCCTGTTCTTGCTGGCAGGCGGGGGTCATCTGGATAACTGGGCTGATTGGTTGGCTGATCACCATCATCACAGCCAAGAAGGACATTGGCCAGCCGTCACTGGCACCCTTGGGGACTGGCGACCCTTCCCTGACCCGACCCTCTGCCCCCTCAGAGGCCTTGCCACCAGATGCACTCATCAGCAAGATCGCCATCCAGGGCTCCCTAGCTGTGGGTCAGAACTGGTTATTGGATGAGCAAACCAGCACCCTCACAAGGCTGCGCTACTCTTACCGGGTCATCTGCAGTGACAACTACTATGGAGACAACTGCTCCCGCCTGTGCAAGAAGCGCAATGACCACTTCGGCCACTATGTGTGCCAGCCAGATGGCAACTTGTCCTGCCTGCCCGGTTGGACTGGGGAATATTGCCAACAGCGTAAGCAGTCAAGCTCCCACCTGTGTGGAAGGGGAGGGTCCCCTGAGGAAACACAGTGGAGCTTCTTGGTCACAGCTTGCCTCCCTTGAAGAGTGGGTCTGGGCCTCCTACTAGCTGGGCCTCAGGGATGCTGAGGGTGGGCTTGACCTCAGACCTCCTGTCTCTTCCCAGTGCTCCTCCCATCATGCCAAAGCCCACAAGAACCCCATCATGACATTCCATCCAGTTTGGCTTCTCCTTCCCTGTGCCATTATTTCACTTTAAGACACTCGGGGCTCCTCTGGGAGGCCAGGAGTAGGAAGAGGGCCCAGGAGAGCTAGGGGATCCCCAGGGCCAGCAGGTGAGAATGGGGCTTAAGAGTCCTTGGTATCCCAGCCTCACCCAGCTCTGTGTTCTTCCCTTAGCTATCTGTCTTTCGGGCTGTCATGAACAGAATGGCTACTGCAGCAAGCCAGCAGAGTGCCTGTGAGTAGGGGACAGGAAGTGGTGAGTGGGAGCCCTCCCTTGGCCAAGGCCTCTCACCTCACTCTGCCTCTCTCTTGTTCCCCAGCTGCCGCCCAGGCTGGCAGGGCCGGCTGTGTAACGAATGCATCCCCCACAATGGCTGTCGCCACGGCACCTGCAGCACTCCCTGGCAATGTACTTGTGATGAGGGCTGGGGAGGCCTGTTTTGTGACCAAGGTGAGTCAGGGTGAAGAGAGGGTGCAGAGGGTGCAAGAGATATGGGGCTGGGGGGTGGAAATCCGATTCGTCACCTGGATCCTTCTTACTTGGTGACTGCAGACTTGGCTTTCCCATGATCTTCCAAGGATCTTGGGTCTTTTAAGGATCTTTACAACTGGCCCAGAATGAGGCGGTGGGTCCTTCTCCAGGTGCGGCGGCAGGGGGTGGTGGAGCCAGGGTGGCTGAAAAACCCAGGGGGGTGACAAGGTCGGCAGCCTGGAGGTTGCACTCATAAATCCTAGCAAAGCCAAAGAGAGAGGGATGGCAGGCTCAGTTCCTCTTTCAACCCCGTAGTTACCTATTAACCCCCTGAGTGTTTGCTTACCTTCCAGGGCTGTTTGAGCAGCTCTCCCCTAAACAGCTGTCCGGTGGGGTGTGCCCACCGGCCACCTGAGGCTGTGGGTGAGCTGGGCCTCTGGGCGGAGTGGCATCTAACCGACTTTTCGGTGTGGGCACAAACGGCCTCCCCTGCTCTTACCTAGTTACCACCTGCCTGAACCCATGCGGTCTCTACCTGGTGTTTAGGGGTAGTCACTCTCTGGCTATACAGGGGCCTTTCAGCCCCAACCTTGGGGGAGGAGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGG
GCGAACAGAGCCAGATTGAGGGCCCGCGGGTGGAGAGAGCGACGCCCGAGGGGATGGCGGCAGCGTCCCGGAGCGCCTCTGGCTGGGCGCTACTGCTGCTGGTGGCACTTTGGCAGCAGGTAACACGTCCCGCGCCCTCTCCGTCCCCTCTGCCGCGCTCTGGGCCTCAGCCCCGGGCACCAGCTGAGCTGACCGGTCCCCTCCCTCCTTCCCTCGGTCCCTGTGCAATAGCGCGCGGCCGGCTCCGGCGTCTTCCAGCTGCAGCTGCAGGAGTTCATCAACGAGCGCGGCGTACTGGCCAGTGGGCGGCCTTGCGAGCCCGGCTGCCGGACTTTCTTCCGCGTCTGCCTTAAGCACTTCCAGGCGGTCGTCTCGCCCGGACCCTGCACCTTCGGGACCGTCTCCACGCCGGTATTGGGCACCAACTCCTTCGCTGTCCGGGACGACAGTAGCGGCGGGGGGCGCAACCCTCTCCAACTGCCCTTCAATTTCACCTGGCCGGTGAGCACAGCCTGGGCGCACTGGGAGGTCGCAGAAGCCGAGAGAGGAGGCGCCCTGGGACCAAAGCCCCCTCCCCAGATTTCCTTGTACACACACCCCCACCCCCAAAAAGCCCAGGATGCATTCTTTCCTGGCTCTTCCCGACTCTCTCCTGAGACTGATCCCAGAAAAGGCTCTCACCAGTCTCCGTCTTCCCAGTTTATGTCCTCCCGTCCCCAGCTCTTGGGACACGATTTTCATTACCTACCACTCTGGGGCGGTACCCTACCACCCCCTCCTCCAGTGGCTCTCCCTTACACTCTCCCGTCTCTCAACCCTCCCTCTACCGGGGGTTCTCCTCTCGCCTTCCCTGCTCAAGCGCTACACTGTGCACAGCCCCGTTATGTTGACCCGGGCGCAGTAACTGAATCCTGCAATTAGATTAATTAAACAGGCTGCCGCAAGGCACCCCCACCTCTCCCCGCTTGCTCATCTCGCCATCTCTCCGTCCCCCCACCCCCTTTCCCAGGGTACCTTCTCGCTCATCATCGAAGCTTGGCACGCGCCAGGAGACGACCTGCGGCCAGGTGAGTAGCTCGCTCCGCCACCACAGGGGGGCGACACGGCGCAGCGCCGAAAGAGTTAATCTGTTCTAGGCGGGGGAAGTGCGGGCTTGGGGGTGGGAGGCAGGACGCTTAGCTTGGCCTGGAGCTGCGCCCCGCGCTGGACGCTCGGATTCCGCTCGCTGCCTGGACTCAGAGCACAATTGCGTTTCCTGCGGGTTATTTTTGGCGTGGGAACGCGGGGAGTACGGCGGTGAGAAAGGCTGAAGCTGCCAGCGCCGCTGACGGGCCCCTTCCTGTATTTTACACCTTTCGCGAATTCCGCTCCTTTGGAAAGGGAATAATGGCTTTGGGATGTTGTTCTGACACAGAGGAAAAGGATATTTCAGCAGCACAACAATTCTCACTTTGAAAAGGAAAAAAGAAAACCATTACCCACCTCTGGAGGCAGAACCCCTGAATGGGCACCAAAGGACCCCCTGCTCCCAGGGTCCTCTCTAGCCTGGGGAGCTTTTCTTTCTTTTTCTCTTTTTTCCATTTTGACCTCTTTTCCTCTTTCCCCTCCCTATCTGCCTCCAAGACCCTGGGATATCTTAACATCCTTCTATTGTCCCCTTTTTGAATACTATCAGGCCCCCTGCACATGCACACACGTAGGGCAGCTACGTAGCGGGGCTTTGGGTCCCTCTGGCCTGTTCTTGCTGGCAGGCGGGGGTCATCTGGATAACTGGGCTGATTGGTTGGCTGATCACCATCATCACAGCCAAGAAGGACATTGGCCAGCCGTCACTGGCACCCTTGGGGACTGGCGACCCTTCCCTGACCCGACCCTCTGCCCCCTCAGAGGCCTTGCCACCAGATGCACTCATCAGCAAGATCGCCATCCAGGGCTCCCTAGCTGTGGGTCAGAACTGGTTATTGGATGAGCAAACCAGCACCCTCACAAGGCTGCGCTACTCTTACCGGGTCATCTGCAGTGACAACTACTATGGAGACAACTGCTCCTGCCTGTGCAAGAAGCGCAATGACCACTTCGGCCACTATGTGTGCCAGCCAGATGGCAACTTGTCCTGCCTGCCCGGTTGGACTGGGGAATATTGCCAACAGCGTAAGCAGTCAAGCTCCCACCTGTGTGGAAGGGGAGGGTCCCCTGAGGAAACACAGTGGAGCTTCTTGGTCACAGCTTGCCTCCCTTGAAGAGTGGGTCTGGGCCTCCTACTAGCTGGGCCTCAGGGATGCTGAGGGTGGGCTTGACCTCAGACCTCCTGTCTCTTCCCAGTGCTCCTCCCATCATGCCAAAGCCCACAAGAACCCCATCATGACATTCCATCCAGTTTGGCTTCTCCTTCCCTGTGCCATTATTTCACTTTAAGACACTCGGGGCTCCTCTGGGAGGCCAGGAGTAGGAAGAGGGCCCAGGAGAGCTAGGGGATCCCCAGGGCCAGCAGGTGAGAATGGGGCTTAAGAGTCCTTGGTATCCCAGCCTCACCCAGCTCTGTGTTCTTCCCTTAGCTATCTGTCTTTCGGGCTGTCATGAACAGAATGGCTACTGCAGCAAGCCAGCAGAGTGCCTGTGAGTAGGGGACAGGAAGTGGTGAGTGGGAGCCCTCCCTTGGCCAAGGCCTCTCACCTCACTCTGCCTCTCTCTTGTTCCCCAGCTGCCGCCCAGGCTGGCAGGGCCGGCTGTGTAACGAATGCATCCCCCACAATGGCTGTCGCCACGGCACCTGCAGCACTCCCTGGCAATGTACTTGTGATGAGGGCTGGGGAGGCCTGTTTTGTGACCAAGGTGAGTCAGGGTGAAGAGAGGGTGCAGAGGGTGCAAGAGATATGGGGCTGGGGGGTGGAAATCCGATTCGTCACCTGGATCCTTCTTACTTGGTGACTGCAGACTTGGCTTTCCCATGATCTTCCAAGGATCTTGGGTCTTTTAAGGATCTTTACAACTGGCCCAGAATGAGGCGGTGGGTCCTTCTCCAGGTGCGGCGGCAGGGGGTGGTGGAGCCAGGGTGGCTGAAAAACCCAGGGGGGTGACAAGGTCGGCAGCCTGGAGGTTGCACTCATAAATCCTAGCAAAGCCAAAGAGAGAGGGATGGCAGGCTCAGTTCCTCTTTCAACCCCGTAGTTACCTATTAACCCCCTGAGTGTTTGCTTACCTTCCAGGGCTGTTTGAGCAGCTCTCCCCTAAACAGCTGTCCGGTGGGGTGTGCCCACCGGCCACCTGAGGCTGTGGGTGAGCTGGGCCTCTGGGCGGAGTGGCATCTAACCGACTTTTCGGTGTGGGCACAAACGGCCTCCCCTGCTCTTACCTAGTTACCACCTGCCTGAACCCATGCGGTCTCTACCTGGTGTTTAGGGGTAGTCACTCTCTGGCTATACAGGGGCCTTTCAGCCCCAACCTTGGGGGAGGAGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGG
Task1_train_20539
A sequence alteration has been identified in DLL4 (delta like canonical Notch ligand 4) on Chromosome 15. Is it disease-inducing or harmless?
Pathogenic; Adams-Oliver syndrome
GGGTGGAGAGAGCGACGCCCGAGGGGATGGCGGCAGCGTCCCGGAGCGCCTCTGGCTGGGCGCTACTGCTGCTGGTGGCACTTTGGCAGCAGGTAACACGTCCCGCGCCCTCTCCGTCCCCTCTGCCGCGCTCTGGGCCTCAGCCCCGGGCACCAGCTGAGCTGACCGGTCCCCTCCCTCCTTCCCTCGGTCCCTGTGCAATAGCGCGCGGCCGGCTCCGGCGTCTTCCAGCTGCAGCTGCAGGAGTTCATCAACGAGCGCGGCGTACTGGCCAGTGGGCGGCCTTGCGAGCCCGGCTGCCGGACTTTCTTCCGCGTCTGCCTTAAGCACTTCCAGGCGGTCGTCTCGCCCGGACCCTGCACCTTCGGGACCGTCTCCACGCCGGTATTGGGCACCAACTCCTTCGCTGTCCGGGACGACAGTAGCGGCGGGGGGCGCAACCCTCTCCAACTGCCCTTCAATTTCACCTGGCCGGTGAGCACAGCCTGGGCGCACTGGGAGGTCGCAGAAGCCGAGAGAGGAGGCGCCCTGGGACCAAAGCCCCCTCCCCAGATTTCCTTGTACACACACCCCCACCCCCAAAAAGCCCAGGATGCATTCTTTCCTGGCTCTTCCCGACTCTCTCCTGAGACTGATCCCAGAAAAGGCTCTCACCAGTCTCCGTCTTCCCAGTTTATGTCCTCCCGTCCCCAGCTCTTGGGACACGATTTTCATTACCTACCACTCTGGGGCGGTACCCTACCACCCCCTCCTCCAGTGGCTCTCCCTTACACTCTCCCGTCTCTCAACCCTCCCTCTACCGGGGGTTCTCCTCTCGCCTTCCCTGCTCAAGCGCTACACTGTGCACAGCCCCGTTATGTTGACCCGGGCGCAGTAACTGAATCCTGCAATTAGATTAATTAAACAGGCTGCCGCAAGGCACCCCCACCTCTCCCCGCTTGCTCATCTCGCCATCTCTCCGTCCCCCCACCCCCTTTCCCAGGGTACCTTCTCGCTCATCATCGAAGCTTGGCACGCGCCAGGAGACGACCTGCGGCCAGGTGAGTAGCTCGCTCCGCCACCACAGGGGGGCGACACGGCGCAGCGCCGAAAGAGTTAATCTGTTCTAGGCGGGGGAAGTGCGGGCTTGGGGGTGGGAGGCAGGACGCTTAGCTTGGCCTGGAGCTGCGCCCCGCGCTGGACGCTCGGATTCCGCTCGCTGCCTGGACTCAGAGCACAATTGCGTTTCCTGCGGGTTATTTTTGGCGTGGGAACGCGGGGAGTACGGCGGTGAGAAAGGCTGAAGCTGCCAGCGCCGCTGACGGGCCCCTTCCTGTATTTTACACCTTTCGCGAATTCCGCTCCTTTGGAAAGGGAATAATGGCTTTGGGATGTTGTTCTGACACAGAGGAAAAGGATATTTCAGCAGCACAACAATTCTCACTTTGAAAAGGAAAAAAGAAAACCATTACCCACCTCTGGAGGCAGAACCCCTGAATGGGCACCAAAGGACCCCCTGCTCCCAGGGTCCTCTCTAGCCTGGGGAGCTTTTCTTTCTTTTTCTCTTTTTTCCATTTTGACCTCTTTTCCTCTTTCCCCTCCCTATCTGCCTCCAAGACCCTGGGATATCTTAACATCCTTCTATTGTCCCCTTTTTGAATACTATCAGGCCCCCTGCACATGCACACACGTAGGGCAGCTACGTAGCGGGGCTTTGGGTCCCTCTGGCCTGTTCTTGCTGGCAGGCGGGGGTCATCTGGATAACTGGGCTGATTGGTTGGCTGATCACCATCATCACAGCCAAGAAGGACATTGGCCAGCCGTCACTGGCACCCTTGGGGACTGGCGACCCTTCCCTGACCCGACCCTCTGCCCCCTCAGAGGCCTTGCCACCAGATGCACTCATCAGCAAGATCGCCATCCAGGGCTCCCTAGCTGTGGGTCAGAACTGGTTATTGGATGAGCAAACCAGCACCCTCACAAGGCTGCGCTACTCTTACCGGGTCATCTGCAGTGACAACTACTATGGAGACAACTGCTCCCGCCTGTGCAAGAAGCGCAATGACCACTTCGGCCACTATGTGTGCCAGCCAGATGGCAACTTGTCCTGCCTGCCCGGTTGGACTGGGGAATATTGCCAACAGCGTAAGCAGTCAAGCTCCCACCTGTGTGGAAGGGGAGGGTCCCCTGAGGAAACACAGTGGAGCTTCTTGGTCACAGCTTGCCTCCCTTGAAGAGTGGGTCTGGGCCTCCTACTAGCTGGGCCTCAGGGATGCTGAGGGTGGGCTTGACCTCAGACCTCCTGTCTCTTCCCAGTGCTCCTCCCATCATGCCAAAGCCCACAAGAACCCCATCATGACATTCCATCCAGTTTGGCTTCTCCTTCCCTGTGCCATTATTTCACTTTAAGACACTCGGGGCTCCTCTGGGAGGCCAGGAGTAGGAAGAGGGCCCAGGAGAGCTAGGGGATCCCCAGGGCCAGCAGGTGAGAATGGGGCTTAAGAGTCCTTGGTATCCCAGCCTCACCCAGCTCTGTGTTCTTCCCTTAGCTATCTGTCTTTCGGGCTGTCATGAACAGAATGGCTACTGCAGCAAGCCAGCAGAGTGCCTGTGAGTAGGGGACAGGAAGTGGTGAGTGGGAGCCCTCCCTTGGCCAAGGCCTCTCACCTCACTCTGCCTCTCTCTTGTTCCCCAGCTGCCGCCCAGGCTGGCAGGGCCGGCTGTGTAACGAATGCATCCCCCACAATGGCTGTCGCCACGGCACCTGCAGCACTCCCTGGCAATGTACTTGTGATGAGGGCTGGGGAGGCCTGTTTTGTGACCAAGGTGAGTCAGGGTGAAGAGAGGGTGCAGAGGGTGCAAGAGATATGGGGCTGGGGGGTGGAAATCCGATTCGTCACCTGGATCCTTCTTACTTGGTGACTGCAGACTTGGCTTTCCCATGATCTTCCAAGGATCTTGGGTCTTTTAAGGATCTTTACAACTGGCCCAGAATGAGGCGGTGGGTCCTTCTCCAGGTGCGGCGGCAGGGGGTGGTGGAGCCAGGGTGGCTGAAAAACCCAGGGGGGTGACAAGGTCGGCAGCCTGGAGGTTGCACTCATAAATCCTAGCAAAGCCAAAGAGAGAGGGATGGCAGGCTCAGTTCCTCTTTCAACCCCGTAGTTACCTATTAACCCCCTGAGTGTTTGCTTACCTTCCAGGGCTGTTTGAGCAGCTCTCCCCTAAACAGCTGTCCGGTGGGGTGTGCCCACCGGCCACCTGAGGCTGTGGGTGAGCTGGGCCTCTGGGCGGAGTGGCATCTAACCGACTTTTCGGTGTGGGCACAAACGGCCTCCCCTGCTCTTACCTAGTTACCACCTGCCTGAACCCATGCGGTCTCTACCTGGTGTTTAGGGGTAGTCACTCTCTGGCTATACAGGGGCCTTTCAGCCCCAACCTTGGGGGAGGAGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGGGTTGGCAGTTTGTGAGTTTCCCTGGCA
GGGTGGAGAGAGCGACGCCCGAGGGGATGGCGGCAGCGTCCCGGAGCGCCTCTGGCTGGGCGCTACTGCTGCTGGTGGCACTTTGGCAGCAGGTAACACGTCCCGCGCCCTCTCCGTCCCCTCTGCCGCGCTCTGGGCCTCAGCCCCGGGCACCAGCTGAGCTGACCGGTCCCCTCCCTCCTTCCCTCGGTCCCTGTGCAATAGCGCGCGGCCGGCTCCGGCGTCTTCCAGCTGCAGCTGCAGGAGTTCATCAACGAGCGCGGCGTACTGGCCAGTGGGCGGCCTTGCGAGCCCGGCTGCCGGACTTTCTTCCGCGTCTGCCTTAAGCACTTCCAGGCGGTCGTCTCGCCCGGACCCTGCACCTTCGGGACCGTCTCCACGCCGGTATTGGGCACCAACTCCTTCGCTGTCCGGGACGACAGTAGCGGCGGGGGGCGCAACCCTCTCCAACTGCCCTTCAATTTCACCTGGCCGGTGAGCACAGCCTGGGCGCACTGGGAGGTCGCAGAAGCCGAGAGAGGAGGCGCCCTGGGACCAAAGCCCCCTCCCCAGATTTCCTTGTACACACACCCCCACCCCCAAAAAGCCCAGGATGCATTCTTTCCTGGCTCTTCCCGACTCTCTCCTGAGACTGATCCCAGAAAAGGCTCTCACCAGTCTCCGTCTTCCCAGTTTATGTCCTCCCGTCCCCAGCTCTTGGGACACGATTTTCATTACCTACCACTCTGGGGCGGTACCCTACCACCCCCTCCTCCAGTGGCTCTCCCTTACACTCTCCCGTCTCTCAACCCTCCCTCTACCGGGGGTTCTCCTCTCGCCTTCCCTGCTCAAGCGCTACACTGTGCACAGCCCCGTTATGTTGACCCGGGCGCAGTAACTGAATCCTGCAATTAGATTAATTAAACAGGCTGCCGCAAGGCACCCCCACCTCTCCCCGCTTGCTCATCTCGCCATCTCTCCGTCCCCCCACCCCCTTTCCCAGGGTACCTTCTCGCTCATCATCGAAGCTTGGCACGCGCCAGGAGACGACCTGCGGCCAGGTGAGTAGCTCGCTCCGCCACCACAGGGGGGCGACACGGCGCAGCGCCGAAAGAGTTAATCTGTTCTAGGCGGGGGAAGTGCGGGCTTGGGGGTGGGAGGCAGGACGCTTAGCTTGGCCTGGAGCTGCGCCCCGCGCTGGACGCTCGGATTCCGCTCGCTGCCTGGACTCAGAGCACAATTGCGTTTCCTGCGGGTTATTTTTGGCGTGGGAACGCGGGGAGTACGGCGGTGAGAAAGGCTGAAGCTGCCAGCGCCGCTGACGGGCCCCTTCCTGTATTTTACACCTTTCGCGAATTCCGCTCCTTTGGAAAGGGAATAATGGCTTTGGGATGTTGTTCTGACACAGAGGAAAAGGATATTTCAGCAGCACAACAATTCTCACTTTGAAAAGGAAAAAAGAAAACCATTACCCACCTCTGGAGGCAGAACCCCTGAATGGGCACCAAAGGACCCCCTGCTCCCAGGGTCCTCTCTAGCCTGGGGAGCTTTTCTTTCTTTTTCTCTTTTTTCCATTTTGACCTCTTTTCCTCTTTCCCCTCCCTATCTGCCTCCAAGACCCTGGGATATCTTAACATCCTTCTATTGTCCCCTTTTTGAATACTATCAGGCCCCCTGCACATGCACACACGTAGGGCAGCTACGTAGCGGGGCTTTGGGTCCCTCTGGCCTGTTCTTGCTGGCAGGCGGGGGTCATCTGGATAACTGGGCTGATTGGTTGGCTGATCACCATCATCACAGCCAAGAAGGACATTGGCCAGCCGTCACTGGCACCCTTGGGGACTGGCGACCCTTCCCTGACCCGACCCTCTGCCCCCTCAGAGGCCTTGCCACCAGATGCACTCATCAGCAAGATCGCCATCCAGGGCTCCCTAGCTGTGGGTCAGAACTGGTTATTGGATGAGCAAACCAGCACCCTCACAAGGCTGCGCTACTCTTACCGGGTCATCTGCAGTGACAACTACTATGGAGACAACTGCTCCCGCCTGTGCAAGAAGCGCAATGACCACCTCGGCCACTATGTGTGCCAGCCAGATGGCAACTTGTCCTGCCTGCCCGGTTGGACTGGGGAATATTGCCAACAGCGTAAGCAGTCAAGCTCCCACCTGTGTGGAAGGGGAGGGTCCCCTGAGGAAACACAGTGGAGCTTCTTGGTCACAGCTTGCCTCCCTTGAAGAGTGGGTCTGGGCCTCCTACTAGCTGGGCCTCAGGGATGCTGAGGGTGGGCTTGACCTCAGACCTCCTGTCTCTTCCCAGTGCTCCTCCCATCATGCCAAAGCCCACAAGAACCCCATCATGACATTCCATCCAGTTTGGCTTCTCCTTCCCTGTGCCATTATTTCACTTTAAGACACTCGGGGCTCCTCTGGGAGGCCAGGAGTAGGAAGAGGGCCCAGGAGAGCTAGGGGATCCCCAGGGCCAGCAGGTGAGAATGGGGCTTAAGAGTCCTTGGTATCCCAGCCTCACCCAGCTCTGTGTTCTTCCCTTAGCTATCTGTCTTTCGGGCTGTCATGAACAGAATGGCTACTGCAGCAAGCCAGCAGAGTGCCTGTGAGTAGGGGACAGGAAGTGGTGAGTGGGAGCCCTCCCTTGGCCAAGGCCTCTCACCTCACTCTGCCTCTCTCTTGTTCCCCAGCTGCCGCCCAGGCTGGCAGGGCCGGCTGTGTAACGAATGCATCCCCCACAATGGCTGTCGCCACGGCACCTGCAGCACTCCCTGGCAATGTACTTGTGATGAGGGCTGGGGAGGCCTGTTTTGTGACCAAGGTGAGTCAGGGTGAAGAGAGGGTGCAGAGGGTGCAAGAGATATGGGGCTGGGGGGTGGAAATCCGATTCGTCACCTGGATCCTTCTTACTTGGTGACTGCAGACTTGGCTTTCCCATGATCTTCCAAGGATCTTGGGTCTTTTAAGGATCTTTACAACTGGCCCAGAATGAGGCGGTGGGTCCTTCTCCAGGTGCGGCGGCAGGGGGTGGTGGAGCCAGGGTGGCTGAAAAACCCAGGGGGGTGACAAGGTCGGCAGCCTGGAGGTTGCACTCATAAATCCTAGCAAAGCCAAAGAGAGAGGGATGGCAGGCTCAGTTCCTCTTTCAACCCCGTAGTTACCTATTAACCCCCTGAGTGTTTGCTTACCTTCCAGGGCTGTTTGAGCAGCTCTCCCCTAAACAGCTGTCCGGTGGGGTGTGCCCACCGGCCACCTGAGGCTGTGGGTGAGCTGGGCCTCTGGGCGGAGTGGCATCTAACCGACTTTTCGGTGTGGGCACAAACGGCCTCCCCTGCTCTTACCTAGTTACCACCTGCCTGAACCCATGCGGTCTCTACCTGGTGTTTAGGGGTAGTCACTCTCTGGCTATACAGGGGCCTTTCAGCCCCAACCTTGGGGGAGGAGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGGGTTGGCAGTTTGTGAGTTTCCCTGGCA
Task1_train_20540
Consider a variant on Chromosome 15 in gene DLL4 (delta like canonical Notch ligand 4). Determine its clinical classification and disease relevance.
Pathogenic; Adams-Oliver syndrome
TCTCTACCTGGTGTTTAGGGGTAGTCACTCTCTGGCTATACAGGGGCCTTTCAGCCCCAACCTTGGGGGAGGAGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGGGTTGGCAGTTTGTGAGTTTCCCTGGCAGGACGTCTTCCAGTTCCAGTTGTGTTGTTTCACTTTTGGTTGACTGCACTGGTCATATGTGATTCAAGGTGCTTTAAGAAACATGATTTTCATCCTGGCTAACACAGTGAAACCCTGTCTGTATTAAAAATACAAAAGTTAGCCAGGTGTGGTGGCAGGCACCTGTAGCCCCAGCTGCTGGGAAGGCTGAGGCAGGAGAATGGCGAAGTAGAGCTTGCAGTGAGCCGAGGTCGTGCCACTGCACTCCAGCCTGAGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAACATGATTTTAGGCTGGGTGCGATGGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTAGGTGGATCACTTGAAGTCAGGAGTTCGAGACCATCCTGGCCATCCTGGTGAAACCCCTGTAAAAATACAAATATTAATCGGGCACAGTGGCGCATGCCTGTAATCCCAGCTACTTAGAAGGTTGAGGTATGAGAATCGCTTGAACCCGGAAGGCGAAGGTTGTAGTGAGCCTATATCACATCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTC
TCTCTACCTGGTGTTTAGGGGTAGTCACTCTCTGGCTATACAGGGGCCTTTCAGCCCCAACCTTGGGGGAGGAGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGGGTTGGCAGTTTGTGAGTTTCCCTGGCAGGACGTCTTCCAGTTCCAGTTGTGTTGTTTCACTTTTGGTTGACTGCACTGGTCATATGTGATTCAAGGTGCTTTAAGAAACATGATTTTCATCCTGGCTAACACAGTGAAACCCTGTCTGTATTAAAAATACAAAAGTTAGCCAGGTGTGGTGGCAGGCACCTGTAGCCCCAGCTGCTGGGAAGGCTGAGGCAGGAGAATGGCGAAGTAGAGCTTGCAGTGAGCCGAGGTCGTGCCACTGCACTCCAGCCTGAGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAACATGATTTTAGGCTGGGTGCGATGGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTAGGTGGATCACTTGAAGTCAGGAGTTCGAGACCATCCTGGCCATCCTGGTGAAACCCCTGTAAAAATACAAATATTAATCGGGCACAGTGGCGCATGCCTGTAATCCCAGCTACTTAGAAGGTTGAGGTATGAGAATCGCTTGAACCCGGAAGGCGAAGGTTGTAGTGAGCCTATATCACATCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAACGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTC
Task1_train_20541
Given this variant in gene DLL4 (delta like canonical Notch ligand 4) on Chromosome 15, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Adams-Oliver syndrome
CTCTACCTGGTGTTTAGGGGTAGTCACTCTCTGGCTATACAGGGGCCTTTCAGCCCCAACCTTGGGGGAGGAGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGGGTTGGCAGTTTGTGAGTTTCCCTGGCAGGACGTCTTCCAGTTCCAGTTGTGTTGTTTCACTTTTGGTTGACTGCACTGGTCATATGTGATTCAAGGTGCTTTAAGAAACATGATTTTCATCCTGGCTAACACAGTGAAACCCTGTCTGTATTAAAAATACAAAAGTTAGCCAGGTGTGGTGGCAGGCACCTGTAGCCCCAGCTGCTGGGAAGGCTGAGGCAGGAGAATGGCGAAGTAGAGCTTGCAGTGAGCCGAGGTCGTGCCACTGCACTCCAGCCTGAGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAACATGATTTTAGGCTGGGTGCGATGGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTAGGTGGATCACTTGAAGTCAGGAGTTCGAGACCATCCTGGCCATCCTGGTGAAACCCCTGTAAAAATACAAATATTAATCGGGCACAGTGGCGCATGCCTGTAATCCCAGCTACTTAGAAGGTTGAGGTATGAGAATCGCTTGAACCCGGAAGGCGAAGGTTGTAGTGAGCCTATATCACATCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCC
CTCTACCTGGTGTTTAGGGGTAGTCACTCTCTGGCTATACAGGGGCCTTTCAGCCCCAACCTTGGGGGAGGAGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGGGTTGGCAGTTTGTGAGTTTCCCTGGCAGGACGTCTTCCAGTTCCAGTTGTGTTGTTTCACTTTTGGTTGACTGCACTGGTCATATGTGATTCAAGGTGCTTTAAGAAACATGATTTTCATCCTGGCTAACACAGTGAAACCCTGTCTGTATTAAAAATACAAAAGTTAGCCAGGTGTGGTGGCAGGCACCTGTAGCCCCAGCTGCTGGGAAGGCTGAGGCAGGAGAATGGCGAAGTAGAGCTTGCAGTGAGCCGAGGTCGTGCCACTGCACTCCAGCCTGAGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAACATGATTTTAGGCTGGGTGCGATGGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTAGGTGGATCACTTGAAGTCAGGAGTTCGAGACCATCCTGGCCATCCTGGTGAAACCCCTGTAAAAATACAAATATTAATCGGGCACAGTGGCGCATGCCTGTAATCCCAGCTACTTAGAAGGTTGAGGTATGAGAATCGCTTGAACCCGGAAGGCGAAGGTTGTAGTGAGCCTATATCACATCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATATCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCC
Task1_train_20542
Gene DLL4 (delta like canonical Notch ligand 4), found on Chromosome 15, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; not provided
AGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGGGTTGGCAGTTTGTGAGTTTCCCTGGCAGGACGTCTTCCAGTTCCAGTTGTGTTGTTTCACTTTTGGTTGACTGCACTGGTCATATGTGATTCAAGGTGCTTTAAGAAACATGATTTTCATCCTGGCTAACACAGTGAAACCCTGTCTGTATTAAAAATACAAAAGTTAGCCAGGTGTGGTGGCAGGCACCTGTAGCCCCAGCTGCTGGGAAGGCTGAGGCAGGAGAATGGCGAAGTAGAGCTTGCAGTGAGCCGAGGTCGTGCCACTGCACTCCAGCCTGAGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAACATGATTTTAGGCTGGGTGCGATGGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTAGGTGGATCACTTGAAGTCAGGAGTTCGAGACCATCCTGGCCATCCTGGTGAAACCCCTGTAAAAATACAAATATTAATCGGGCACAGTGGCGCATGCCTGTAATCCCAGCTACTTAGAAGGTTGAGGTATGAGAATCGCTTGAACCCGGAAGGCGAAGGTTGTAGTGAGCCTATATCACATCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCCCATTCATTCATTTGTTCATTCACACATGTCAAGTGTCCCTAGGGTGTCTCTTGTGACTTCCGTCTTTCCAC
AGGAAGCCTTTTTTCTTGCATCCTGCTAGCCAGCTGCAGCCAGCTGCAGCTCCCATTTTCAGGATCAAATGGGTGCACCTGCTGCCCAGAGACACCGGCGCAGGCCTGGGTAGGGTGGGCAGAGAGCTTGCCAGGGTGGAAAGAAATTGCCTAGGCCCTGACTTGCTGTCAACAAGGGGCTTGGGATTCAGTCCCTGTGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCCCTTTACTACCATCCCCACCCCAACACTCACACACCTGGTTCCTGCTCATTCTCTTCCCTCTCCACCATATTTGCTCCCAGGTGACACAGTCATATACTCATCATATGCAAACACAGCACTTGCAGGCCATATATTTACTCTGTCTGGTTCTCCCTCCCTGTCCTTCCCAAATAAAAAAACAAATACTTATATTTCAAAATACCCTTGTAACACCTCTTCCTTTAAAAAATGCCCGATTACTGCCTATGGTGGCTCTCATCTCTCCTCTACCATTTCTACCTGTTGAAATTTTATCCCTCCTTCCAGGCTTATCTCAGCTGCCCCTCCTCCATGAAGCCTTTTCTGACTTCCTCCCCGACATGTGGCCTTGCCCTCTGCTCTTCTTCCTTATCTTCATCCTACTTGGGTTGGCAGTTTGTGAGTTTCCCTGGCAGGACGTCTTCCAGTTCCAGTTGTGTTGTTTCACTTTTGGTTGACTGCACTGGTCATATGTGATTCAAGGTGCTTTAAGAAACATGATTTTCATCCTGGCTAACACAGTGAAACCCTGTCTGTATTAAAAATACAAAAGTTAGCCAGGTGTGGTGGCAGGCACCTGTAGCCCCAGCTGCTGGGAAGGCTGAGGCAGGAGAATGGCGAAGTAGAGCTTGCAGTGAGCCGAGGTCGTGCCACTGCACTCCAGCCTGAGTGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAACATGATTTTAGGCTGGGTGCGATGGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTAGGTGGATCACTTGAAGTCAGGAGTTCGAGACCATCCTGGCCATCCTGGTGAAACCCCTGTAAAAATACAAATATTAATCGGGCACAGTGGCGCATGCCTGTAATCCCAGCTACTTAGAAGGTTGAGGTATGAGAATCGCTTGAACCCGGAAGGCGAAGGTTGTAGTGAGCCTATATCACATCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACAGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCCCATTCATTCATTTGTTCATTCACACATGTCAAGTGTCCCTAGGGTGTCTCTTGTGACTTCCGTCTTTCCAC
Task1_train_20543
This alteration in DLL4 (delta like canonical Notch ligand 4) on Chromosome 15 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Adams-Oliver syndrome 6
CCGGAAGGCGAAGGTTGTAGTGAGCCTATATCACATCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCCCATTCATTCATTTGTTCATTCACACATGTCAAGTGTCCCTAGGGTGTCTCTTGTGACTTCCGTCTTTCCACAGTGTGGCTTGCCTCTAGTGGCAGCACTGGCTTTATGCAGGGCTCAGACCCTTCTGGTGAGGTTGGGAGGCCTGTGACTCTCTTAGGGGCCTTTTCCTAAGTGCCCCCCTGCAGCAGCCCAGCACTGGGCACGTCCAGCCCCTGTGTCTTCCCCAAGAACCACCCTGCAGATGCCCTTTGGCTCTCCAGGGTCCTCCCTCCCCCCAAGCCTCTCCCCGTCCCTCCCTTACACGCCTGTCTTGTGTTCCCTCAGTGAAAAGCCAGAGTGTCGGATATCAGCGATATGCTCCCCCAGGGACTCCATGTACCAGTCTGTGTGTTTGATATCAGAGGAGAGGAATGAATGTGTCATTGCCACGGAGGTGAGTGCTGGGCTCGCCTTTCCTTCTGCCTTTTGTGGGAGGGAAAGTGGCCTGGTCACTCTTGACCCATGGGCCATTCCTGAAGGGTAGGTCAGAACCCTGCCTTGGCAGGCCAAGTTCAGTGGACTCTTGGGTCCCTGCTGGCCTCATTGCCACTAAGGGTGTGAAACAGGAACCATGGCGGCAAGCCTGGTCTGGTCCTTTCCTGCTGTATTGGTGCTGGGTTGGGCAGCCACGGCACTGCTGGCCAGCCTCTGATGGGTGAGGGGGCCCCTCACCCCTTGTGCCCTTCCTGCCCCTTCCCACTGGCTTCCTCCATTGACCTCATGAGCGCAAGCTCCCAGGCCCGTGTGTGTGTTGGGCCGAAGACTGGGGAGGACTGCCCCACCTGCCCTTAGCCCCTGCCTGCCCCATCGCCTTCTCCCAGGGAGGCCCAGGGAGGGCCTGGAGGGAGTGCGCATGCCCAGGGTAACCTGTTTCCCTGCCTTCCGCTTGCTCCCAGGTATAAGGCAGGAGCCTACCTGGACATCCCTGCTCAGCCCCGCGGCTGGACCTTCCTTCTGCATTGTTTACATTGCATCCTGGATGGGACGTTTTTCATATGCAACGTGCTGCTCTCAGGAGGAGGAGGGAATGGCAGGAACCGGACAGACTGTGAACTTGCCAAGAGATGCAATACCCTTCCACACCTTTGGGTGTCTGTCTGGCATCAGATTGGCAGCTGCACCAACCAGAGGAACAGAAGAGAAGAGAGATGCCACTGGGCACTGCCCTGCCAGTAGTGGCCTTCAGGGGGCTCCTTCCGGGGCTCCGGCCTG
CCGGAAGGCGAAGGTTGTAGTGAGCCTATATCACATCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTCTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCCCATTCATTCATTTGTTCATTCACACATGTCAAGTGTCCCTAGGGTGTCTCTTGTGACTTCCGTCTTTCCACAGTGTGGCTTGCCTCTAGTGGCAGCACTGGCTTTATGCAGGGCTCAGACCCTTCTGGTGAGGTTGGGAGGCCTGTGACTCTCTTAGGGGCCTTTTCCTAAGTGCCCCCCTGCAGCAGCCCAGCACTGGGCACGTCCAGCCCCTGTGTCTTCCCCAAGAACCACCCTGCAGATGCCCTTTGGCTCTCCAGGGTCCTCCCTCCCCCCAAGCCTCTCCCCGTCCCTCCCTTACACGCCTGTCTTGTGTTCCCTCAGTGAAAAGCCAGAGTGTCGGATATCAGCGATATGCTCCCCCAGGGACTCCATGTACCAGTCTGTGTGTTTGATATCAGAGGAGAGGAATGAATGTGTCATTGCCACGGAGGTGAGTGCTGGGCTCGCCTTTCCTTCTGCCTTTTGTGGGAGGGAAAGTGGCCTGGTCACTCTTGACCCATGGGCCATTCCTGAAGGGTAGGTCAGAACCCTGCCTTGGCAGGCCAAGTTCAGTGGACTCTTGGGTCCCTGCTGGCCTCATTGCCACTAAGGGTGTGAAACAGGAACCATGGCGGCAAGCCTGGTCTGGTCCTTTCCTGCTGTATTGGTGCTGGGTTGGGCAGCCACGGCACTGCTGGCCAGCCTCTGATGGGTGAGGGGGCCCCTCACCCCTTGTGCCCTTCCTGCCCCTTCCCACTGGCTTCCTCCATTGACCTCATGAGCGCAAGCTCCCAGGCCCGTGTGTGTGTTGGGCCGAAGACTGGGGAGGACTGCCCCACCTGCCCTTAGCCCCTGCCTGCCCCATCGCCTTCTCCCAGGGAGGCCCAGGGAGGGCCTGGAGGGAGTGCGCATGCCCAGGGTAACCTGTTTCCCTGCCTTCCGCTTGCTCCCAGGTATAAGGCAGGAGCCTACCTGGACATCCCTGCTCAGCCCCGCGGCTGGACCTTCCTTCTGCATTGTTTACATTGCATCCTGGATGGGACGTTTTTCATATGCAACGTGCTGCTCTCAGGAGGAGGAGGGAATGGCAGGAACCGGACAGACTGTGAACTTGCCAAGAGATGCAATACCCTTCCACACCTTTGGGTGTCTGTCTGGCATCAGATTGGCAGCTGCACCAACCAGAGGAACAGAAGAGAAGAGAGATGCCACTGGGCACTGCCCTGCCAGTAGTGGCCTTCAGGGGGCTCCTTCCGGGGCTCCGGCCTG
Task1_train_20544
A genomic change on Chromosome 15 affects DLL4 (delta like canonical Notch ligand 4). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Adams-Oliver syndrome
CGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCCCATTCATTCATTTGTTCATTCACACATGTCAAGTGTCCCTAGGGTGTCTCTTGTGACTTCCGTCTTTCCACAGTGTGGCTTGCCTCTAGTGGCAGCACTGGCTTTATGCAGGGCTCAGACCCTTCTGGTGAGGTTGGGAGGCCTGTGACTCTCTTAGGGGCCTTTTCCTAAGTGCCCCCCTGCAGCAGCCCAGCACTGGGCACGTCCAGCCCCTGTGTCTTCCCCAAGAACCACCCTGCAGATGCCCTTTGGCTCTCCAGGGTCCTCCCTCCCCCCAAGCCTCTCCCCGTCCCTCCCTTACACGCCTGTCTTGTGTTCCCTCAGTGAAAAGCCAGAGTGTCGGATATCAGCGATATGCTCCCCCAGGGACTCCATGTACCAGTCTGTGTGTTTGATATCAGAGGAGAGGAATGAATGTGTCATTGCCACGGAGGTGAGTGCTGGGCTCGCCTTTCCTTCTGCCTTTTGTGGGAGGGAAAGTGGCCTGGTCACTCTTGACCCATGGGCCATTCCTGAAGGGTAGGTCAGAACCCTGCCTTGGCAGGCCAAGTTCAGTGGACTCTTGGGTCCCTGCTGGCCTCATTGCCACTAAGGGTGTGAAACAGGAACCATGGCGGCAAGCCTGGTCTGGTCCTTTCCTGCTGTATTGGTGCTGGGTTGGGCAGCCACGGCACTGCTGGCCAGCCTCTGATGGGTGAGGGGGCCCCTCACCCCTTGTGCCCTTCCTGCCCCTTCCCACTGGCTTCCTCCATTGACCTCATGAGCGCAAGCTCCCAGGCCCGTGTGTGTGTTGGGCCGAAGACTGGGGAGGACTGCCCCACCTGCCCTTAGCCCCTGCCTGCCCCATCGCCTTCTCCCAGGGAGGCCCAGGGAGGGCCTGGAGGGAGTGCGCATGCCCAGGGTAACCTGTTTCCCTGCCTTCCGCTTGCTCCCAGGTATAAGGCAGGAGCCTACCTGGACATCCCTGCTCAGCCCCGCGGCTGGACCTTCCTTCTGCATTGTTTACATTGCATCCTGGATGGGACGTTTTTCATATGCAACGTGCTGCTCTCAGGAGGAGGAGGGAATGGCAGGAACCGGACAGACTGTGAACTTGCCAAGAGATGCAATACCCTTCCACACCTTTGGGTGTCTGTCTGGCATCAGATTGGCAGCTGCACCAACCAGAGGAACAGAAGAGAAGAGAGATGCCACTGGGCACTGCCCTGCCAGTAGTGGCCTTCAGGGGGCTCCTTCCGGGGCTCCGGCCTGTTTTCCAGAGAGAGTGGCAGTAGCCCCATGGGGCCCGGAGCTGCTGTGGCCTCCA
CGACAGAGTGAGACTCTGTTAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGGCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCCCATTCATTCATTTGTTCATTCACACATGTCAAGTGTCCCTAGGGTGTCTCTTGTGACTTCCGTCTTTCCACAGTGTGGCTTGCCTCTAGTGGCAGCACTGGCTTTATGCAGGGCTCAGACCCTTCTGGTGAGGTTGGGAGGCCTGTGACTCTCTTAGGGGCCTTTTCCTAAGTGCCCCCCTGCAGCAGCCCAGCACTGGGCACGTCCAGCCCCTGTGTCTTCCCCAAGAACCACCCTGCAGATGCCCTTTGGCTCTCCAGGGTCCTCCCTCCCCCCAAGCCTCTCCCCGTCCCTCCCTTACACGCCTGTCTTGTGTTCCCTCAGTGAAAAGCCAGAGTGTCGGATATCAGCGATATGCTCCCCCAGGGACTCCATGTACCAGTCTGTGTGTTTGATATCAGAGGAGAGGAATGAATGTGTCATTGCCACGGAGGTGAGTGCTGGGCTCGCCTTTCCTTCTGCCTTTTGTGGGAGGGAAAGTGGCCTGGTCACTCTTGACCCATGGGCCATTCCTGAAGGGTAGGTCAGAACCCTGCCTTGGCAGGCCAAGTTCAGTGGACTCTTGGGTCCCTGCTGGCCTCATTGCCACTAAGGGTGTGAAACAGGAACCATGGCGGCAAGCCTGGTCTGGTCCTTTCCTGCTGTATTGGTGCTGGGTTGGGCAGCCACGGCACTGCTGGCCAGCCTCTGATGGGTGAGGGGGCCCCTCACCCCTTGTGCCCTTCCTGCCCCTTCCCACTGGCTTCCTCCATTGACCTCATGAGCGCAAGCTCCCAGGCCCGTGTGTGTGTTGGGCCGAAGACTGGGGAGGACTGCCCCACCTGCCCTTAGCCCCTGCCTGCCCCATCGCCTTCTCCCAGGGAGGCCCAGGGAGGGCCTGGAGGGAGTGCGCATGCCCAGGGTAACCTGTTTCCCTGCCTTCCGCTTGCTCCCAGGTATAAGGCAGGAGCCTACCTGGACATCCCTGCTCAGCCCCGCGGCTGGACCTTCCTTCTGCATTGTTTACATTGCATCCTGGATGGGACGTTTTTCATATGCAACGTGCTGCTCTCAGGAGGAGGAGGGAATGGCAGGAACCGGACAGACTGTGAACTTGCCAAGAGATGCAATACCCTTCCACACCTTTGGGTGTCTGTCTGGCATCAGATTGGCAGCTGCACCAACCAGAGGAACAGAAGAGAAGAGAGATGCCACTGGGCACTGCCCTGCCAGTAGTGGCCTTCAGGGGGCTCCTTCCGGGGCTCCGGCCTGTTTTCCAGAGAGAGTGGCAGTAGCCCCATGGGGCCCGGAGCTGCTGTGGCCTCCA
Task1_train_20545
Here’s a variant in DLL4 (delta like canonical Notch ligand 4) located on Chromosome 15. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Adams-Oliver syndrome 6
AAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTGCCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCCCATTCATTCATTTGTTCATTCACACATGTCAAGTGTCCCTAGGGTGTCTCTTGTGACTTCCGTCTTTCCACAGTGTGGCTTGCCTCTAGTGGCAGCACTGGCTTTATGCAGGGCTCAGACCCTTCTGGTGAGGTTGGGAGGCCTGTGACTCTCTTAGGGGCCTTTTCCTAAGTGCCCCCCTGCAGCAGCCCAGCACTGGGCACGTCCAGCCCCTGTGTCTTCCCCAAGAACCACCCTGCAGATGCCCTTTGGCTCTCCAGGGTCCTCCCTCCCCCCAAGCCTCTCCCCGTCCCTCCCTTACACGCCTGTCTTGTGTTCCCTCAGTGAAAAGCCAGAGTGTCGGATATCAGCGATATGCTCCCCCAGGGACTCCATGTACCAGTCTGTGTGTTTGATATCAGAGGAGAGGAATGAATGTGTCATTGCCACGGAGGTGAGTGCTGGGCTCGCCTTTCCTTCTGCCTTTTGTGGGAGGGAAAGTGGCCTGGTCACTCTTGACCCATGGGCCATTCCTGAAGGGTAGGTCAGAACCCTGCCTTGGCAGGCCAAGTTCAGTGGACTCTTGGGTCCCTGCTGGCCTCATTGCCACTAAGGGTGTGAAACAGGAACCATGGCGGCAAGCCTGGTCTGGTCCTTTCCTGCTGTATTGGTGCTGGGTTGGGCAGCCACGGCACTGCTGGCCAGCCTCTGATGGGTGAGGGGGCCCCTCACCCCTTGTGCCCTTCCTGCCCCTTCCCACTGGCTTCCTCCATTGACCTCATGAGCGCAAGCTCCCAGGCCCGTGTGTGTGTTGGGCCGAAGACTGGGGAGGACTGCCCCACCTGCCCTTAGCCCCTGCCTGCCCCATCGCCTTCTCCCAGGGAGGCCCAGGGAGGGCCTGGAGGGAGTGCGCATGCCCAGGGTAACCTGTTTCCCTGCCTTCCGCTTGCTCCCAGGTATAAGGCAGGAGCCTACCTGGACATCCCTGCTCAGCCCCGCGGCTGGACCTTCCTTCTGCATTGTTTACATTGCATCCTGGATGGGACGTTTTTCATATGCAACGTGCTGCTCTCAGGAGGAGGAGGGAATGGCAGGAACCGGACAGACTGTGAACTTGCCAAGAGATGCAATACCCTTCCACACCTTTGGGTGTCTGTCTGGCATCAGATTGGCAGCTGCACCAACCAGAGGAACAGAAGAGAAGAGAGATGCCACTGGGCACTGCCCTGCCAGTAGTGGCCTTCAGGGGGCTCCTTCCGGGGCTCCGGCCTGTTTTCCAGAGAGAGTGGCAGTAGCCCCATGGGGCCCGGAGCTGCTGTGGCCTCCACTGGCATCCGTGTTTCCAAAAGTGCCTTTGGC
AAAAGAAGGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAGAAAGAAAAAAGATTTTATTGGTGGTGGAGGAAGGATGTTTGGGCCTGGGAGACTTTGAGTTGAGGTGTCTTTGAGCCAAACATGGGGGCAAACATGGACTGCAAGGAGCCTGGAGGTGAGTGCATTCCCTGGCCCTGCTCAGCTGCTTGGTTCCTGTTTCTGCAGATCTCAACTACTGCACCCACCACTCCCCATGCAAGAATGGGGCAACGTGCTCCAACAGTGGGCAGCGAAGCTACACCTGCACCTGTCGCCCAGGCTACACTGGTGTGGACTGTGAGCTGGAGCTCAGCGAGTGTGACAGCAACCCCTGTCGCAATGGAGGCAGCTGTAAGGTGAGGCCCAGACCAGCGCAGGAAGACAGAGGTGTCAGGTGGTGTCTGGGCATCCCTAACCTAGGCAGTTAGTGGATGTACAGCCATGGACAGGCATTGTGGGCAGGTGGAGCCCAGCCTTCAGTCACACATCCCTGCCCCCCAGGGTCTGACTTTGGCCCCTTTATGGTCTCTCTCCAGGACCAGGAGGATGGCTACCACTGCCTGTGTCCTCCGGGCTACTATGGCCTGCATTGTGAACACAGCACCTTGAGCTGCGCCGACTCCCCCTGCTTCAATGGGGGCTCCTGCCGGGAGCGCAACCAGGGGGCCAACTATGCTTGTGAATGTCCCCCCAACTTCACCGGCTCCAACTGCGAGAAGAAAGTGGACAGGTGCACCAGCAACCCCTGTGCCAACGGTGCGTGCTGCTGCCCTGCTAACCTGGTGGACTGGCCCTGGGGCTGAGAGAGACTTCTGGTGAGGGAGGGTCAGGAGAGGAGCGAGGCATTGTCTGCCACTCTGGCCCCCCATCTGCTCTGGAGGGCGAAGAGCTTGCTTGATCAGCTGGGGGGCTGTGGAAGCGGAGCTGGTTAGTTGCACGCAGGCCTTAGGAGCAGGGGTGGTATGCACCCTGCATAGCTTCCATTCCTATTCCCATGTCAGAACCCCGTCCTGGCTGGGGTGGCCTCTGACCCTCCCCAGGAAGTCCTGAGCTGGAGAGAGGGATGTTGGAGGCTTCATGTTTCTCCTCAAAGGAGGCAGTGATTCAGTCAGAGCCCTGCTCCTGGAGGCCTCATCTTGCCCCGTGCCCAGGTAGAGCATGAGGTAGCATGAGGCATCTTGAATGTTTGCACCTTTTGAGGCACAAAGCCTGTTGGTAATCCTTGTCTATCTGGCTCCCAGGTGACCCTCTGTGAGGCAGGCAGGCAGGCAGCGCTCAGGAGCTGGAGAGGGGTGGGAAGGGCTGAGAGGGAGTCTGCTCTCTCACTGAAGCCTCTGGCACTGCCATTTCTTCATCACTGAATGGGAAACTATAATACCTGTCCTCTGTCCTTCATGTGGTTGTGAAGATGAAGTAAAACAGTCATGATTGTACTTATCCGAGCATTAACTATATACCAAACATGGGCTCTTGCCTTCATGTACCTTCCCGGCTATCCTATGAAGGGGCTAGCATTCTACTCCAGTCTAACAAATGGGGAAACTGAGGCTTAGAGACACGGTTAAGCAGCAAGTGCCAGATCTCAGGCCACAGAGTGACAGCTGAGGTCCCAACTCAAGCCTATCTGTCTGATTCTACGTTAAAGTTCTGTAAGATGCTAGTCATTTTTATACATGAGCCCACTGAGGCCGAGAGAATCAAGGTCATGCTAAACTCCAGGTCTCCTGACTCTGTGCAGTTCTCTTTGTAGTGGGCTCTGCAGGTGGAGGTAGAAGGGCCCGAACGTGTTCCTGGAATGGGGCTCCCACCCCCTGCCCCAGGGAGCTCCCAGGCTATCACTGACTTGTGTCTCATGCGTCCTCACAGGGGGACAGTGCCTGAACCGAGGTCCAAGCCGCATGTGCCGCTGCCGTCCTGGATTCACGGGCACCTACTGTGAACTCCACGTCAGCGACTGTGCCCGTAACCCTTGCGCCCACGGTGGCACTTGCCATGACCTGGAGAATGGGCTCATGTGCACCTACCCTGCCGGCTTCTCTGGCCGACGCTGTGAGGTGCGGACATCCATCGATGCCTGTGCCTCGAGTCCCTGCTTCAACAGGGCCACCTGCTACACCGACCTCTCCACAGACACCTTTGTGTGCAACTGCCCTTATGGCTTTGTGGGCAGCCGCTGCGAGTTCCCCGTGGGCTTGCCGCCCAGCTTCCCCTGGGTGGCCGTCTCGCTGGGTGTGGGGCTGGCAGTGCTGCTGGTACTGCTGGGCATGGTGGCAGTGGCTGTGCGGCAGCTGCGGCTTCGACGGCCGGACGACGGCAGCAGGGAAGCCATGAACAACTTGTCGGACTTCCAGAAGGACAACCTGATTCCTGCCGCCCAGCTTAAAAACACAAACCAGAAGAAGGAGCTGGAAGTGGACTGTGGCCTGGACAAGTCCAACTGTGGCAAACAGCAAAACCACACATTGGACTATAATCTGGCCCCAGGGCCCCTGGGGCGGGGGACCATGCCAGGAAAGTTTCCCCACAGTGACAAGAGCTTAGGAGAGAAGGCGCCACTGCGGTTACACAGGTGAGTGGCACCCAGAAGCCCAGGGCCTGGCCACCGGCCCCGACATGGTTCTGCCTAGGCTCCTCTTAGGCCAGGCGGGAAGCAGTTAAGCAGCTGAGGTTTTGTTACTGACAGGAAGATCCTCCAGTAGGATTTCTGTCAGGGGTCCTTTGTCCTTCCCTCCCATTCATTCATTTGTTCATTCACACATGTCAAGTGTCCCTAGGGTGTCTCTTGTGACTTCCGTCTTTCCACAGTGTGGCTTGCCTCTAGTGGCAGCACTGGCTTTATGCAGGGCTCAGACCCTTCTGGTGAGGTTGGGAGGCCTGTGACTCTCTTAGGGGCCTTTTCCTAAGTGCCCCCCTGCAGCAGCCCAGCACTGGGCACGTCCAGCCCCTGTGTCTTCCCCAAGAACCACCCTGCAGATGCCCTTTGGCTCTCCAGGGTCCTCCCTCCCCCCAAGCCTCTCCCCGTCCCTCCCTTACACGCCTGTCTTGTGTTCCCTCAGTGAAAAGCCAGAGTGTCGGATATCAGCGATATGCTCCCCCAGGGACTCCATGTACCAGTCTGTGTGTTTGATATCAGAGGAGAGGAATGAATGTGTCATTGCCACGGAGGTGAGTGCTGGGCTCGCCTTTCCTTCTGCCTTTTGTGGGAGGGAAAGTGGCCTGGTCACTCTTGACCCATGGGCCATTCCTGAAGGGTAGGTCAGAACCCTGCCTTGGCAGGCCAAGTTCAGTGGACTCTTGGGTCCCTGCTGGCCTCATTGCCACTAAGGGTGTGAAACAGGAACCATGGCGGCAAGCCTGGTCTGGTCCTTTCCTGCTGTATTGGTGCTGGGTTGGGCAGCCACGGCACTGCTGGCCAGCCTCTGATGGGTGAGGGGGCCCCTCACCCCTTGTGCCCTTCCTGCCCCTTCCCACTGGCTTCCTCCATTGACCTCATGAGCGCAAGCTCCCAGGCCCGTGTGTGTGTTGGGCCGAAGACTGGGGAGGACTGCCCCACCTGCCCTTAGCCCCTGCCTGCCCCATCGCCTTCTCCCAGGGAGGCCCAGGGAGGGCCTGGAGGGAGTGCGCATGCCCAGGGTAACCTGTTTCCCTGCCTTCCGCTTGCTCCCAGGTATAAGGCAGGAGCCTACCTGGACATCCCTGCTCAGCCCCGCGGCTGGACCTTCCTTCTGCATTGTTTACATTGCATCCTGGATGGGACGTTTTTCATATGCAACGTGCTGCTCTCAGGAGGAGGAGGGAATGGCAGGAACCGGACAGACTGTGAACTTGCCAAGAGATGCAATACCCTTCCACACCTTTGGGTGTCTGTCTGGCATCAGATTGGCAGCTGCACCAACCAGAGGAACAGAAGAGAAGAGAGATGCCACTGGGCACTGCCCTGCCAGTAGTGGCCTTCAGGGGGCTCCTTCCGGGGCTCCGGCCTGTTTTCCAGAGAGAGTGGCAGTAGCCCCATGGGGCCCGGAGCTGCTGTGGCCTCCACTGGCATCCGTGTTTCCAAAAGTGCCTTTGGC
Task1_train_20546
This is a variant in NDUFAF1 (NADH:ubiquinone oxidoreductase complex assembly factor 1), located on Chromosome 15. Is this mutation a likely cause of disease or not?
Pathogenic; Mitochondrial complex 1 deficiency, nuclear type 11
CCTGGACCAGGGTGGGAGTAGAAGAGATGGCTAGAAATGGTCAGCTGCTGAGTGTATTTTGGAAGCAGAGGTGACAGGACTCGCTAATAGACTGGATGTGGGGCAAAGGAGAAGAATTCAGGATGACCCTCAAGTATATGACATGAGCAAAATGGGGACTTTCTTGTTGAGTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGGTCTCAGCTTACTGCAACCTCCACCTCCCAAGTTCAAGCAATCCTCCTGCCTCAGCCCCCCTAGTAGCTGGGATTACAGGCACACACCACCATGCCCGGCTAATTTTTTTTTTTTTTTTTTTTTTTTTGAGACGAAGTCTCCCGCCCAGCCTGGAGTGCAGTGGCACGATCTGCAAGCTCTGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCTGCCACCAAGCCCGGCTAATTTTTTTTGTATTTTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGAATGGTCTCCATCATCTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTAAGCCACCGCGGCCGGCCTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCGCCAGGCTGGAGAGCAGTGGCCCATCTCGGCTCACTGCCACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACGACGCCACCACACCCAACTAATTTTTTTATTTTTAGTAGAGACAGAGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTCTAATTCTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTAGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATTTACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGACATGAGCCACCACGCCTGGCCTAGGACACTACTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAAAGTTTGGCTCTTGTTGCCCAGGCTGGAGTGCAATGACACGATCTCGGCTCACCGAAACCTCCGCCTCCTGGGTTCAAGCAATTATCCTGCCTTAGCCTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCCAGCTAATTTTGTATTTTTTTTAGTAGAGACAACAGGGTTTCTCCATGTTGGTCAGGCTGGTGTCGAACTCCCAACCTCAAGTGATCCGTCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCAGGCCTAGGACACCAACTTTAGCAGAGTTGCCTGGAAGACATGAAATGGCAGAAACTTCTAAAAAACAAACAAACCCCATCTATTTGGACACAGAGCAGAGATGTGCCTGTGACTTAGCATGGACCTGGCCACATCCATATCAAAAATATTCACTAGTTAGTATGTTAACATTTATATTAATGAAACAAAATTCATTTATGTCTCTTAACCTTTCTTCTACCCACCCACCCCCACCTTCCAAGAAAGATTAGTAACAAAAAAGAAACTACAATGTAACAATCATCTCCAAGACTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATCTCACTCTGTTGCCCAGGCTGGAGTACAATGGCACGATCAGAGACTAGGTTTCACCATGTTGGCCAACCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAATTGCTGGGATTATAGGCGTGAGCCACCTCACCCAGCCAAGACCTCATTTTTATAAACAATGAAGATTTATGCTGTTACCTTGACCTCCTGCCAGTAGGGTCCCCCGCGGGTGAACATGAAGTAACTATACATCTGATTCGTCCTCTGGAAGAAATCTGTGTCCTCCTTGATATTCACCATCCAAGGCCGACCATCCCCACGTACACGGAGATACAGAGTATTGAACTGGGACCAATCGTAAGACATCTTCCTCTCAAAAGCACCCTAAGATATTGAAAGTAAAGTTCATTGTACCTCATTCTCCATTATTAGCAAAATGTGAGTCATCACCAAGTCAGCATCATCAACAGGATGCACTAACCATTTTTCTGACTTTCTGCCCCATAAGAAGGCACATAAACCCAGTGATTATTATTTTAGCACAAAATACTGACATAGTTATATGTTTCTAAGGTAATGTTCAACACACAACTGGCCCAGGACAGTGTTTACATGGGGTAGGCACTCACCTGTGTTCAATGAATGGAAATGAATGTATTTCCTTTACCTGGTCGTATGGAGCAATGACTTTTTCTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAAGCTCTGCCTCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGTACTATAGGCGCCCAAAACCACACCCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTGGTGATCCGCCCACCTTGGCCACCCAAAGTGTGGGGATTACAGGCATGAGCCACTGCGCCCGGCCTTTTTTTTTTTTTTTTTTTTTTGAGACAAAGTTTCGCTCTTGTTGCCCAGACTGGAGTGCAATGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCAGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTACCTGGAATTACAGGCATGCACCACCATGTCCAGCACTCTGGGAGGCCAAGGGTGGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGTGCACCAGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGAGGGCGGAAGTTGCAGTGAGCCGAGATCACGCCACTGCACTCTAGCCTGGGCGACAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAGAAAGCCACAGGCTAACCCTACATCCACTCTACAAAACCCCTGGTCATTACAGAGGTTGTGGTCTTTTTTAGAGGAGATGAAAATCTCTCCAAAAATCTTTCAAATGTCTAACCTCTCAGGATTCCTGAAACATAACAATGCTCGTTCCTGGCCCAAAGCAATGCGCAGAAACAAGTTAACTCCTCCTCCTCAGAAACCACTTCCCCCTTGTGCTTCCACTTCACACTTGTGCCAATAGTTACTTATCCCCAGACACAGGTGAGGTGCCAAATATAACATGCCAGGTGTTTTCATTTACAGAAACAAAAGCTATCTTCTATAGTTTATGCTACAATGAAGTTCACCCCTGTTTACTAGAAAACGATGGCTCCTGGGCCTCACCTACCCTTGGAATCCTGGATATCATTGCACAGTACCCACTTCGGGTAGACTCCCCGTCCTGAGGCGCCTCAGAGCTCAGAGTTCCATATAGCAGTGCACTTTGGTTATTCTTGCCCATTTTCAAAAACACTTCACTTCTGCCTCCAATCGTCTTATCAGAAGTCACTGTCCACTTATCCAAATCTTCTTTCCCCCGGAATTGCCAGACAACCTTGGCTTGTTCCAGCAAGACCTCATGCAGAGGGTGGCCTTCCGGTCCTCTCCAATGATCCACAATTTCATCCTTCAAAAGCCTAAAATGGTATATTGCTTCATCTCTAATTGCTTTATCGAAACTAACATCAGGCTTCTCCTCAGAAGAAGTTATATCCAAAGCAACTTCTTTCTGGTGATCTCCTTGCAAATCCCCTTCAGTCTTCCTCTGTGAGGAGGCTTTGCCAGGAGAAGCCACTGGTTTCTGAAGACTACTGGAATACTCTGCAAAGCGAATACCCAAAAATGGATACAAGGCAGAAGTTGGCTTAGAGAATTTTCTGAGAAAATAAGTACCACGCAGCAATTTGT
CCTGGACCAGGGTGGGAGTAGAAGAGATGGCTAGAAATGGTCAGCTGCTGAGTGTATTTTGGAAGCAGAGGTGACAGGACTCGCTAATAGACTGGATGTGGGGCAAAGGAGAAGAATTCAGGATGACCCTCAAGTATATGACATGAGCAAAATGGGGACTTTCTTGTTGAGTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGGTCTCAGCTTACTGCAACCTCCACCTCCCAAGTTCAAGCAATCCTCCTGCCTCAGCCCCCCTAGTAGCTGGGATTACAGGCACACACCACCATGCCCGGCTAATTTTTTTTTTTTTTTTTTTTTTTTTGAGACGAAGTCTCCCGCCCAGCCTGGAGTGCAGTGGCACGATCTGCAAGCTCTGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCTGCCACCAAGCCCGGCTAATTTTTTTTGTATTTTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGAATGGTCTCCATCATCTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTAAGCCACCGCGGCCGGCCTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCGCCAGGCTGGAGAGCAGTGGCCCATCTCGGCTCACTGCCACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACGACGCCACCACACCCAACTAATTTTTTTATTTTTAGTAGAGACAGAGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTCTAATTCTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTAGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATTTACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGACATGAGCCACCACGCCTGGCCTAGGACACTACTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAAAGTTTGGCTCTTGTTGCCCAGGCTGGAGTGCAATGACACGATCTCGGCTCACCGAAACCTCCGCCTCCTGGGTTCAAGCAATTATCCTGCCTTAGCCTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCCAGCTAATTTTGTATTTTTTTTAGTAGAGACAACAGGGTTTCTCCATGTTGGTCAGGCTGGTGTCGAACTCCCAACCTCAAGTGATCCGTCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCAGGCCTAGGACACCAACTTTAGCAGAGTTGCCTGGAAGACATGAAATGGCAGAAACTTCTAAAAAACAAACAAACCCCATCTATTTGGACACAGAGCAGAGATGTGCCTGTGACTTAGCATGGACCTGGCCACATCCATATCAAAAATATTCACTAGTTAGTATGTTAACATTTATATTAATGAAACAAAATTCATTTATGTCTCTTAACCTTTCTTCTACCCACCCACCCCCACCTTCCAAGAAAGATTAGTAACAAAAAAGAAACTACAATGTAACAATCATCTCCAAGACTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATCTCACTCTGTTGCCCAGGCTGGAGTACAATGGCACGATCAGAGACTAGGTTTCACCATGTTGGCCAACCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAATTGCTGGGATTATAGGCGTGAGCCACCTCACCCAGCCAAGACCTCATTTTTATAAACAATGAAGATTTATGCTGTTACCTTGACCTCCTGCCAGTAGGGTCCCCCGCGGGTGAACATGAAGTAACTATACATCTGATTCGTCCTCTGGAAGAAATCTGTGTCCTCCTTGATATTCACCATCCAAGGCCGACCATCCCCACGTACACGGAGATACAGAGGATTGAACTGGGACCAATCGTAAGACATCTTCCTCTCAAAAGCACCCTAAGATATTGAAAGTAAAGTTCATTGTACCTCATTCTCCATTATTAGCAAAATGTGAGTCATCACCAAGTCAGCATCATCAACAGGATGCACTAACCATTTTTCTGACTTTCTGCCCCATAAGAAGGCACATAAACCCAGTGATTATTATTTTAGCACAAAATACTGACATAGTTATATGTTTCTAAGGTAATGTTCAACACACAACTGGCCCAGGACAGTGTTTACATGGGGTAGGCACTCACCTGTGTTCAATGAATGGAAATGAATGTATTTCCTTTACCTGGTCGTATGGAGCAATGACTTTTTCTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAAGCTCTGCCTCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGTACTATAGGCGCCCAAAACCACACCCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTGGTGATCCGCCCACCTTGGCCACCCAAAGTGTGGGGATTACAGGCATGAGCCACTGCGCCCGGCCTTTTTTTTTTTTTTTTTTTTTTGAGACAAAGTTTCGCTCTTGTTGCCCAGACTGGAGTGCAATGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCAGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTACCTGGAATTACAGGCATGCACCACCATGTCCAGCACTCTGGGAGGCCAAGGGTGGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGTGCACCAGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGAGGGCGGAAGTTGCAGTGAGCCGAGATCACGCCACTGCACTCTAGCCTGGGCGACAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAGAAAGCCACAGGCTAACCCTACATCCACTCTACAAAACCCCTGGTCATTACAGAGGTTGTGGTCTTTTTTAGAGGAGATGAAAATCTCTCCAAAAATCTTTCAAATGTCTAACCTCTCAGGATTCCTGAAACATAACAATGCTCGTTCCTGGCCCAAAGCAATGCGCAGAAACAAGTTAACTCCTCCTCCTCAGAAACCACTTCCCCCTTGTGCTTCCACTTCACACTTGTGCCAATAGTTACTTATCCCCAGACACAGGTGAGGTGCCAAATATAACATGCCAGGTGTTTTCATTTACAGAAACAAAAGCTATCTTCTATAGTTTATGCTACAATGAAGTTCACCCCTGTTTACTAGAAAACGATGGCTCCTGGGCCTCACCTACCCTTGGAATCCTGGATATCATTGCACAGTACCCACTTCGGGTAGACTCCCCGTCCTGAGGCGCCTCAGAGCTCAGAGTTCCATATAGCAGTGCACTTTGGTTATTCTTGCCCATTTTCAAAAACACTTCACTTCTGCCTCCAATCGTCTTATCAGAAGTCACTGTCCACTTATCCAAATCTTCTTTCCCCCGGAATTGCCAGACAACCTTGGCTTGTTCCAGCAAGACCTCATGCAGAGGGTGGCCTTCCGGTCCTCTCCAATGATCCACAATTTCATCCTTCAAAAGCCTAAAATGGTATATTGCTTCATCTCTAATTGCTTTATCGAAACTAACATCAGGCTTCTCCTCAGAAGAAGTTATATCCAAAGCAACTTCTTTCTGGTGATCTCCTTGCAAATCCCCTTCAGTCTTCCTCTGTGAGGAGGCTTTGCCAGGAGAAGCCACTGGTTTCTGAAGACTACTGGAATACTCTGCAAAGCGAATACCCAAAAATGGATACAAGGCAGAAGTTGGCTTAGAGAATTTTCTGAGAAAATAAGTACCACGCAGCAATTTGT
Task1_train_20547
Mutation context: Chromosome 15, Gene NDUFAF1 (NADH:ubiquinone oxidoreductase complex assembly factor 1). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; not provided
GACCAATCGTAAGACATCTTCCTCTCAAAAGCACCCTAAGATATTGAAAGTAAAGTTCATTGTACCTCATTCTCCATTATTAGCAAAATGTGAGTCATCACCAAGTCAGCATCATCAACAGGATGCACTAACCATTTTTCTGACTTTCTGCCCCATAAGAAGGCACATAAACCCAGTGATTATTATTTTAGCACAAAATACTGACATAGTTATATGTTTCTAAGGTAATGTTCAACACACAACTGGCCCAGGACAGTGTTTACATGGGGTAGGCACTCACCTGTGTTCAATGAATGGAAATGAATGTATTTCCTTTACCTGGTCGTATGGAGCAATGACTTTTTCTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAAGCTCTGCCTCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGTACTATAGGCGCCCAAAACCACACCCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTGGTGATCCGCCCACCTTGGCCACCCAAAGTGTGGGGATTACAGGCATGAGCCACTGCGCCCGGCCTTTTTTTTTTTTTTTTTTTTTTGAGACAAAGTTTCGCTCTTGTTGCCCAGACTGGAGTGCAATGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCAGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTACCTGGAATTACAGGCATGCACCACCATGTCCAGCACTCTGGGAGGCCAAGGGTGGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGTGCACCAGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGAGGGCGGAAGTTGCAGTGAGCCGAGATCACGCCACTGCACTCTAGCCTGGGCGACAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAGAAAGCCACAGGCTAACCCTACATCCACTCTACAAAACCCCTGGTCATTACAGAGGTTGTGGTCTTTTTTAGAGGAGATGAAAATCTCTCCAAAAATCTTTCAAATGTCTAACCTCTCAGGATTCCTGAAACATAACAATGCTCGTTCCTGGCCCAAAGCAATGCGCAGAAACAAGTTAACTCCTCCTCCTCAGAAACCACTTCCCCCTTGTGCTTCCACTTCACACTTGTGCCAATAGTTACTTATCCCCAGACACAGGTGAGGTGCCAAATATAACATGCCAGGTGTTTTCATTTACAGAAACAAAAGCTATCTTCTATAGTTTATGCTACAATGAAGTTCACCCCTGTTTACTAGAAAACGATGGCTCCTGGGCCTCACCTACCCTTGGAATCCTGGATATCATTGCACAGTACCCACTTCGGGTAGACTCCCCGTCCTGAGGCGCCTCAGAGCTCAGAGTTCCATATAGCAGTGCACTTTGGTTATTCTTGCCCATTTTCAAAAACACTTCACTTCTGCCTCCAATCGTCTTATCAGAAGTCACTGTCCACTTATCCAAATCTTCTTTCCCCCGGAATTGCCAGACAACCTTGGCTTGTTCCAGCAAGACCTCATGCAGAGGGTGGCCTTCCGGTCCTCTCCAATGATCCACAATTTCATCCTTCAAAAGCCTAAAATGGTATATTGCTTCATCTCTAATTGCTTTATCGAAACTAACATCAGGCTTCTCCTCAGAAGAAGTTATATCCAAAGCAACTTCTTTCTGGTGATCTCCTTGCAAATCCCCTTCAGTCTTCCTCTGTGAGGAGGCTTTGCCAGGAGAAGCCACTGGTTTCTGAAGACTACTGGAATACTCTGCAAAGCGAATACCCAAAAATGGATACAAGGCAGAAGTTGGCTTAGAGAATTTTCTGAGAAAATAAGTACCACGCAGCAATTTGTGAACCAAAGCCATGGTACAAAAAAATCAAAATGTAAGTTTCTTCCTGGGCTAGCAAGGGCCACCAAGAAGCTTCAGCAAATAGCCCAATTCTACCTATAACAGAAGAGACATTGAAGAATTATCAGCATAGCAATGAATGCATCACAATTTCAAATTCAACAGAAATCAGGTATTTTGAAGTTTGTTAACTTATTTGTTTACTATTATTATTATTATTATTTGAGACAAGGTCTTGCTCTGTGGCCCAGGCTGGGTACAGTGGCACAATCACAGCTCACTGTAGCCTCTACTTTCTGGGCTCAAATGATCCTCCCATCTCAGCCACCCAAGTAGCTGGGATTACAAGCACACACCACCATGCCCAGCTAATTTTTAAATTTTTTGTAGAAATGGATCTCCCTGGCCAGGCACGGTCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACGAGGTCAAGAGATAGAGACTGGGCCGGGCGCGGTGGCTGACGCCTGTAATCCCAGCACTTGGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAAATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTGGGGAGGCTGAAGCAGGAGAATAGCGTCAACCCAGGAGGCAGAGCTTGCAGTGAGCGGAGATCCCGCCACTACACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCGGGAAAAAAAAAAAAAAAAAAATTGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAACTTAGCTGGGTGTGGTGGTGCGCACTTGTGGTCCCAGCTACTAAGGAGGCTGAGGCAAAAGAATTCCTTGAACCTGGGAGGAGGAGGCTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAACAGAAAGAAAGAAAAAGAAATAGATCTCCCTGTGTTGCCCATGATGGTTTTGAACTCCTAGGATCCAGTGATTCTCCCCTCGGCTTCCCAAAGTGCTGGGCTGTAGGAATGATGCACTGTCCCCGGCCTTTTTTTTTTCTTTTCTTTTTATAAGAGACTGGGTCAGGCCAGGTGTGGTAGCTCACGCCTGTAATCTCAACACTTTGGGAGGCCGAGGCGGATGGATCACCTGAGGTAAGGAGTTCGAGACCAGCCTTGACAACATGGTGAAACCCCATCTCTACTAAAAATAATCCAGGCGTGGTGGCAGACGCCTGTAATCCCAGCTACTAGGGAGCCTTAAGCAGGAGAATCACTTGAACCCAGGAGGCAGGGATTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGACAAGAGCAAAATTCCATGTGAAAAAAAAAAAAAAAGAGACAGGGTCTCTTGCTCTGTCACCCAGGCTGCAGCGCCGTGGCAAGATCGATAACTCATTGTAGCCTTGAACTCCTGGGCCCTGGACTGAAATGATTCTCCCACCTCAGCCTCCAAGGTAGCTGAGACTACAGGTGCACACCACCATGCCCAGCTAATTTTTTTAAAAAATGTTGGCCGGGTGCCGTGCATCACACCTGTAATCCCAGCACTTTGGGAGTCCAAGGTGGACGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAAATGGTAAAACCCCATCTCTACTAAAAATACAGAAATTAGTTGGTCATGTTGGAGAGCGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAAAAGTGAAATTCCATCTCAAAAAAAATAAAAAAACCAAAAATTGTAGCCCGCCACAGTGGCTCACACCTGTAATCCCAGCACTCTGGGAGTCTTAGGCAGGCAAATGACTTGTCGTCAGGAGTTGGAGACCAGCCTGCCCAACATGGTAAAACCCCGTCTCCATTAA
GACCAATCGTAAGACATCTTCCTCTCAAAAGCACCCTAAGATATTGAAAGTAAAGTTCATTGTACCTCATTCTCCATTATTAGCAAAATGTGAGTCATCACCAAGTCAGCATCATCAACAGGATGCACTAACCATTTTTCTGACTTTCTGCCCCATAAGAAGGCACATAAACCCAGTGATTATTATTTTAGCACAAAATACTGACATAGTTATATGTTTCTAAGGTAATGTTCAACACACAACTGGCCCAGGACAGTGTTTACATGGGGTAGGCACTCACCTGTGTTCAATGAATGGAAATGAATGTATTTCCTTTACCTGGTCGTATGGAGCAATGACTTTTTCTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAAGCTCTGCCTCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAATAGCTGGTACTATAGGCGCCCAAAACCACACCCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTGGTGATCCGCCCACCTTGGCCACCCAAAGTGTGGGGATTACAGGCATGAGCCACTGCGCCCGGCCTTTTTTTTTTTTTTTTTTTTTTGAGACAAAGTTTCGCTCTTGTTGCCCAGACTGGAGTGCAATGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCAGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTACCTGGAATTACAGGCATGCACCACCATGTCCAGCACTCTGGGAGGCCAAGGGTGGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGTGCACCAGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGAGGGCGGAAGTTGCAGTGAGCCGAGATCACGCCACTGCACTCTAGCCTGGGCGACAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAGAAAGCCACAGGCTAACCCTACATCCACTCTACAAAACCCCTGGTCATTACAGAGGTTGTGGTCTTTTTTAGAGGAGATGAAAATCTCTCCAAAAATCTTTCAAATGTCTAACCTCTCAGGATTCCTGAAACATAACAATGCTCGTTCCTGGCCCAAAGCAATGCGCAGAAACAAGTTAACTCCTCCTCCTCAGAAACCACTTCCCCCTTGTGCTTCCACTTCACACTTGTGCCAATAGTTACTTATCCCCAGACACAGGTGAGGTGCCAAATATAACATGCCAGGTGTTTTCATTTACAGAAACAAAAGCTATCTTCTATAGTTTATGCTACAATGAAGTTCACCCCTGTTTACTAGAAAACGATGGCTCCTGGGCCTCACCTACCCTTGGAATCCTGGATATCATTGCACAGTACCCACTTCGGGTAGACTCCCCGTCCTGAGGCGCCTCAGAGCTCAGAGTTCCATATAGCAGTGCACTTTGGTTATTCTTGCCCATTTTCAAAAACACTTCACTTCTGCCTCCAATCGTCTTATCAGAAGTCACTGTCCACTTATCCAAATCTTCTTTCCCCCGGAATTGCCAGACAACCTTGGCTTGTTCCAGCAAGACCTCATGCAGAGGGTGGCCTTCCGGTCCTCTCCAATGATCCACAATTTCATCCTTCAAAAGCCTAAAATGGTATATTGCTTCATCTCTAATTGCTTTATCGAAACTAACATCAGGCTTCTCCTCAGAAGAAGTTATATCCAAAGCAACTTCTTTCTGGTGATCTCCTTGCAAATCCCCTTCAGTCTTCCTCTGTGAGGAGGCTTTGCCAGGAGAAGCCACTGGTTTCTGAAGACTACTGGAATACTCTGCAAAGCGAATACCCAAAAATGGATACAAGGCAGAAGTTGGCTTAGAGAATTTTCTGAGAAAATAAGTACCACGCAGCAATTTGTGAACCAAAGCCGTGGTACAAAAAAATCAAAATGTAAGTTTCTTCCTGGGCTAGCAAGGGCCACCAAGAAGCTTCAGCAAATAGCCCAATTCTACCTATAACAGAAGAGACATTGAAGAATTATCAGCATAGCAATGAATGCATCACAATTTCAAATTCAACAGAAATCAGGTATTTTGAAGTTTGTTAACTTATTTGTTTACTATTATTATTATTATTATTTGAGACAAGGTCTTGCTCTGTGGCCCAGGCTGGGTACAGTGGCACAATCACAGCTCACTGTAGCCTCTACTTTCTGGGCTCAAATGATCCTCCCATCTCAGCCACCCAAGTAGCTGGGATTACAAGCACACACCACCATGCCCAGCTAATTTTTAAATTTTTTGTAGAAATGGATCTCCCTGGCCAGGCACGGTCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACGAGGTCAAGAGATAGAGACTGGGCCGGGCGCGGTGGCTGACGCCTGTAATCCCAGCACTTGGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAAATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTGGGGAGGCTGAAGCAGGAGAATAGCGTCAACCCAGGAGGCAGAGCTTGCAGTGAGCGGAGATCCCGCCACTACACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCGGGAAAAAAAAAAAAAAAAAAATTGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAACTTAGCTGGGTGTGGTGGTGCGCACTTGTGGTCCCAGCTACTAAGGAGGCTGAGGCAAAAGAATTCCTTGAACCTGGGAGGAGGAGGCTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAACAGAAAGAAAGAAAAAGAAATAGATCTCCCTGTGTTGCCCATGATGGTTTTGAACTCCTAGGATCCAGTGATTCTCCCCTCGGCTTCCCAAAGTGCTGGGCTGTAGGAATGATGCACTGTCCCCGGCCTTTTTTTTTTCTTTTCTTTTTATAAGAGACTGGGTCAGGCCAGGTGTGGTAGCTCACGCCTGTAATCTCAACACTTTGGGAGGCCGAGGCGGATGGATCACCTGAGGTAAGGAGTTCGAGACCAGCCTTGACAACATGGTGAAACCCCATCTCTACTAAAAATAATCCAGGCGTGGTGGCAGACGCCTGTAATCCCAGCTACTAGGGAGCCTTAAGCAGGAGAATCACTTGAACCCAGGAGGCAGGGATTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGACAAGAGCAAAATTCCATGTGAAAAAAAAAAAAAAAGAGACAGGGTCTCTTGCTCTGTCACCCAGGCTGCAGCGCCGTGGCAAGATCGATAACTCATTGTAGCCTTGAACTCCTGGGCCCTGGACTGAAATGATTCTCCCACCTCAGCCTCCAAGGTAGCTGAGACTACAGGTGCACACCACCATGCCCAGCTAATTTTTTTAAAAAATGTTGGCCGGGTGCCGTGCATCACACCTGTAATCCCAGCACTTTGGGAGTCCAAGGTGGACGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAAATGGTAAAACCCCATCTCTACTAAAAATACAGAAATTAGTTGGTCATGTTGGAGAGCGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAAAAGTGAAATTCCATCTCAAAAAAAATAAAAAAACCAAAAATTGTAGCCCGCCACAGTGGCTCACACCTGTAATCCCAGCACTCTGGGAGTCTTAGGCAGGCAAATGACTTGTCGTCAGGAGTTGGAGACCAGCCTGCCCAACATGGTAAAACCCCGTCTCCATTAA
Task1_train_20548
A mutation on Chromosome 15 affecting MAPKBP1 (mitogen-activated protein kinase binding protein 1) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Nephronophthisis 20
GAGTTTGAATGTTACAGGCTTCCCCAGTGTGCCCCATCCTTAGTTTTGCCTCGGTCATCTTGGACAAGTTATTGAATTTGACCAAGCCTCAGTTTCCTCACCTGTAAAATGGTGTACTTGATTCACCTAATTGTTCTAAGAATAAAATGAAATAATGTAAGTGGGAGACATAGAAGAGTGCCTGATATATAGTGGGTGCTTCCCCTTGGTCATGTTGAAGGGTATATACCAGTTATGTATGGCCTGTGACAGGCACTGGGCTAAGTCCTGGCCACCATTCCCTTTTTCGTCCCATTCCCTTCCATCTCCTTGGGTAGGCAGAGGACTGCTCCCGAATGGAGGTCTGATTGTGTTCCCTCGGCCTCTTCAGGTCTACCCCGAGGTGAAGGATAGTAACCAGGCCTGCCTGCCCCCCAGTTCCTTTATTACCTGCTCCTCAGACAACACCATCCGCCTGTGGAACACAGAGAGCTCCGGGGTGCATGGCTCCACCCTCCACCGAAACATCCTCAGCAGTGTGAGCCCTGAGGCTGTGGGGCCCCGCTTCACCCTCAGTGCCCCCATCCCCACAGCTATTGCACCTTGTTACTGGGAACTGGTCCCTAGGCCTTGGCCTTCCAGCCTTCATTTGGCTGTGCTCTGTGGTCCAAGGGTTTGTTTTGCTCAGCTTTCTTGCCCCTTGCAGCTGTACTGGTCAGGCCTGCCTCATCCACCTTTTCTAACCTGTTCCACTAGGACCTCATTAAAATCATCTATGTGGATGGGAACACCCAGGCCCTGCTGGACACAGAGCTGCCTGGAGGAGACAAAGCTGATGCATCCCTGTTGGATCCCCGCGTGGGCATCCGCTCGGTGTGTGTCAGCCCCAATGGACAGCATCTAGCATCAGGGGACCGTATGGGCACACTTAGGTAATGCCAGGCCCTGGGTGGGTACTGACTGCCTCTCATGGTGCAGAGTTGGGTATTTAGAACTTTAGGGAGGGTTTGGCTCAAAAAGATTGGGCAACAAGATACTTATTTACAAGGCAAAGATAATAACTTCACAATGAGTAAACCTAGCAGAAATCATCTTCACCAAGTGATCAAGGTTAACATCCTCATATCAACATCATTAAGCCCATGATAGGATGTACTAAGAAGGATGTGACAATGTTTCTGTGGTATTCTTACCAAAAATGCATAAACTCAATATAGGCGTGAGAAAACATCCGACAAACTCACATTGAGGTACATACCACAGAGTAACTGATCAATACTCTTCAAAAACGTCAAGATCATGAAAAGTAAGGAAAGACCAGAGAACTGTTACAGACCACAGAAGTCTAAGGAGAAGTAACTAAATGCAATTTGGATTCTGGATAGGATCTAGAGTCAAGAAAAAGGACATAGTAGGAAAACTGGTGAAATTTGAATAAGGTCTCTAATTAATAGTATTATACCAACATAAATTTCCTAGTTTTGATAATTGCACTATCGTTATGTAAGATGTTCACATTAGGGAAAGCTGGGTAAGGGAAATATAGACGCTCTCTGTTCTTTCAGCAACTTTTCTCTAAGCCTAAAAGTTCAAAAAAAGGAAAAAGGAGGAGAAAATGTAGCAGAGGAGGGGGCGTGAGTCCTTCCTGCGGCCTGGCCATGGCCTCTTCCCACCTCTCCTCATCTTTGCAGGGTGCACGAACTTCAGTCCCTGAGTGAGATGCTGAAGGTGGAGGCCCATGACTCTGAGATTCTGTGCCTGGAGTATTCTAAGCCAGACACAGGTTAGGAGAATGCCCGGAATGGCACAGGGCTCCTCCAGTCCTGCCGGTGCCACTTATATCTGTCCCGGCTCTTGGACGTGGGGTCGGTAATCTTTGGATCATTGGTGTCTTTGCTGGTTTAGAGGAAGACAGCTCTGTCCTTGCTCCATGGTTCACATGGCTTGGGGATATGGGGCTCAGTTCCCTTGGGGCTCTTTGCCAGGCCCAGATAAGGGCTGTTCAGGGCACTCATGGGCTGATGGAGTTCTTTCATCCCCAGGTCTGAAACTGCTAGCATCGGCGAGCCGGGACCGGCTGATCCATGTGCTGGATGCCGGGCGGGAGTACAGCCTACAGCAGACGCTGGACGAACACTCATCCTCCATCACTGCTGTTAAGTTTGCAGGTGCGGGCAGGGTGAATGAGACACATCCTGCCACTCTCACCCCTGCTGCCATCTGCCTCCCACCTCCATGAGAAGGGTCTGCCCATTGTGGGGGAGTGTTGGACAGCAGCTGGGAGGCCTGGAGCTGGTTGGGAAGATAGGTGGAACAGAGACTCTCAGTGCTGGGACTTGAGCCAACCAGGTTGGACTGAGGATAAGGAGACAGGAAAACCTGGGTTTCCAGGTTTAATTTAGTTGGTTTTCCCTGGCATGTAGAGTAGCTTGATGGGGGATCTCATGGAGGGAAGGTGGGAGGCAGGCTGCTCCCATGTGGTGAGAACAGTGGGAACAGCTGGGCTTCCCTCCTTCATAGCCAGTGATGGGCAAGTCCGCATGATCAGCTGTGGAGCAGACAAGAGCATCTACTTCCGCACTGCGCAGAAGGTGAGGGCGCTGGGCTTTCCTGAGAGGGGCGGGACAGGGCGGGGTCTGCCATTCCCTGCCTAAGGTTACAAGAGGTGAAGGGAGGCGCAAGTAGGGCTCTTGGGGCCTGGTGAGGCATTTGGGTGTGGGCCTGCCCACATGCTCCACCCCTGCAGTCTGGAGATGGAGTGCAGTTCACACGGACACACCACGTGGTGCGGAAGACGACCCTCTATGACATGGATGTGGAGCCCAGCTGGAAGTACACGGCTATCGGCTGCCAGGACCGAAATATTCGGTGGGCGTCCCCTCCTCAGACTCTGCCCACATTCCTTCATCTCCCTACGGGGTCAGCTCTGTGCAGCTAAGTTCCCACATCTGTCGTTCTGTACAGGACTTTGTACCCCCTTGAGCCTACAGTACTTTGCTTCACCCAAGAGGTGGTAGCCTGTTTGCTGCTGGGGGTAGCTCCCAGAGAGTGTAGACTGGGAGTGAAAGCTGGCATTTCCATCCCCCAGGCGTGTTCCACCTTCACCGCCTCCTCATGAGAAAGAGACTATGTTTCTTACAGGATATTTAACATCAGCAGTGGAAAGCAGAAGAAGCTGTTTAAAGGGTCACAGGGTGAGGACGGCACACTCATTAAGGTAAGGACCCAGAGGGGGTACTGGACAGGGGCTCGGGGACAGAGTGGTGCTGGGTGGGAGGGACTGGTACTTCCCATGTCCTCCAGCTGCACACCCTGCTACTCCTCAGGTGCAGACAGACCCCTCAGGGATCTACATTGCCACCAGCTGTTCTGACAAGAATCTCTCCATTTTTGACTTCTCCTCAGGCGAGTGCGTGGCCACCATGTTTGGCCACTCAGGTGAGTGTAGCCTGAATCCCCGAGTAGAAGCTGATACCTGCGTAAACCTGAGTGAGTTCCACCCCTGGAACTTCACTCTTCTATTAGTTTCTTGGGACCCGCAGAGCTACCTATCCCTACCCTGCAGCCAACCCCCGTGTCCACTGTTGGGATGGAGAGGACTTGGTTGGGAATTTAAGGTGGCTTATAGACCGTATTCTTTGTTCTTCACAGAGATTGTCACTGGCATGAAATTTAGTAATGATTGTAAACATCTCATCTCTGTGTCTGGGGACAGGTGAGCAGAAGCCAGCTTCCCTGAGAGGCAGATTCTTACTCTGCCACAGCACCCTGCCCTCCCCTCTCTCCATTTCAGTGATGTCTCTGGGAAGTGGGGTTAACAGGGATAGCTTTTGGCTGTGCTTGACCTGAAGTGGAGGGTGGCTCTGGTCTCCTTGCCATCCATGGATAAGGGGAACGAATGGCGCTAGCCATTCTACCTGCCCCTCCTTCAGCCAACTGTGTGGCTTTACCCCAGCTGCATATTTGTGTGGCGCCTGAGCTCTGAGATGACCATCAGCATGAGGCAGCGTCTGGCCGAGTTGCGCCAGCGTCAGCGGGGCGGCAAGCAGCAAGGACCATCCTCTCCCCAAAGGGCTTCTGGACCCAACCGGTGAGAACAGAATGTGGGCAAGTGATG
GAGTTTGAATGTTACAGGCTTCCCCAGTGTGCCCCATCCTTAGTTTTGCCTCGGTCATCTTGGACAAGTTATTGAATTTGACCAAGCCTCAGTTTCCTCACCTGTAAAATGGTGTACTTGATTCACCTAATTGTTCTAAGAATAAAATGAAATAATGTAAGTGGGAGACATAGAAGAGTGCCTGATATATAGTGGGTGCTTCCCCTTGGTCATGTTGAAGGGTATATACCAGTTATGTATGGCCTGTGACAGGCACTGGGCTAAGTCCTGGCCACCATTCCCTTTTTCGTCCCATTCCCTTCCATCTCCTTGGGTAGGCAGAGGACTGCTCCCGAATGGAGGTCTGATTGTGTTCCCTCGGCCTCTTCAGGTCTACCCCGAGGTGAAGGATAGTAACCAGGCCTGCCTGCCCCCCAGTTCCTTTATTACCTGCTCCTCAGACAACACCATCCGCCTGTGGAACACAGAGAGCTCCGGGGTGCATGGCTCCACCCTCCACCGAAACATCCTCAGCAGTGTGAGCCCTGAGGCTGTGGGGCCCCGCTTCACCCTCAGTGCCCCCATCCCCACAGCTATTGCACCTTGTTACTGGGAACTGGTCCCTAGGCCTTGGCCTTCCAGCCTTCATTTGGCTGTGCTCTGTGGTCCAAGGGTTTGTTTTGCTCAGCTTTCTTGCCCCTTGCAGCTGTACTGGTCAGGCCTGCCTCATCCACCTTTTCTAACCTGTTCCACTAGGACCTCATTAAAATCATCTATGTGGATGGGAACACCCAGGCCCTGCTGGACACAGAGCTGCCTGGAGGAGACAAAGCTGATGCATCCCTGTTGGATCCCCGCGTGGGCATCCGCTCGGTGTGTGTCAGCCCCAATGGACAGCATCTAGCATCAGGGGACCGTATGGGCACACTTAGGTAATGCCAGGCCCTGGGTGGGTACTGACTGCCTCTCATGGTGCAGAGTTGGGTATTTAGAACTTTAGGGAGGGTTTGGCTCAAAAAGATTGGGCAACAAGATACTTATTTACAAGGCAAAGATAATAACTTCACAATGAGTAAACCTAGCAGAAATCATCTTCACCAAGTGATCAAGGTTAACATCCTCATATCAACATCATTAAGCCCATGATAGGATGTACTAAGAAGGATGTGACAATGTTTCTGTGGTATTCTTACCAAAAATGCATAAACTCAATATAGGCGTGAGAAAACATCCGACAAACTCACATTGAGGTACATACCACAGAGTAACTGATCAATACTCTTCAAAAACGTCAAGATCATGAAAAGTAAGGAAAGACCAGAGAACTGTTACAGACCACAGAAGTCTAAGGAGAAGTAACTAAATGCAATTTGGATTCTGGATAGGATCTAGAGTCAAGAAAAAGGACATAGTAGGAAAACTGGTGAAATTTGAATAAGGTCTCTAATTAATAGTATTATACCAACATAAATTTCCTAGTTTTGATAATTGCACTATCGTTATGTAAGATGTTCACATTAGGGAAAGCTGGGTAAGGGAAATATAGACGCTCTCTGTTCTTTCAGCAACTTTTCTCTAAGCCTAAAAGTTCAAAAAAAGGAAAAAGGAGGAGAAAATGTAGCAGAGGAGGGGGCGTGAGTCCTTCCTGCGGCCTGGCCATGGCCTCTTCCCACCTCTCCTCATCTTTGCAGGGTGCACGAACTTCAGTCCCTGAGTGAGATGCTGAAGGTGGAGGCCCATGACTCTGAGATTCTGTGCCTGGAGTATTCTAAGCCAGACACAGGTTAGGAGAATGCCCGGAATGGCACAGGGCTCCTCCAGTCCTGCCGGTGCCACTTATATCTGTCCCGGCTCTTGGACGTGGGGTCGGTAATCTTTGGATCATTGGTGTCTTTGCTGGTTTAGAGGAAGACAGCTCTGTCCTTGCTCCATGGTTCACATGGCTTGGGGATATGGGGCTCAGTTCCCTTGGGGCTCTTTGCCAGGCCCAGATAAGGGCTGTTCAGGGCACTCATGGGCTGATGGAGTTCTTTCATCCCCAGGTCTGAAACTGCTAGCATCGGCGAGCCAGGACCGGCTGATCCATGTGCTGGATGCCGGGCGGGAGTACAGCCTACAGCAGACGCTGGACGAACACTCATCCTCCATCACTGCTGTTAAGTTTGCAGGTGCGGGCAGGGTGAATGAGACACATCCTGCCACTCTCACCCCTGCTGCCATCTGCCTCCCACCTCCATGAGAAGGGTCTGCCCATTGTGGGGGAGTGTTGGACAGCAGCTGGGAGGCCTGGAGCTGGTTGGGAAGATAGGTGGAACAGAGACTCTCAGTGCTGGGACTTGAGCCAACCAGGTTGGACTGAGGATAAGGAGACAGGAAAACCTGGGTTTCCAGGTTTAATTTAGTTGGTTTTCCCTGGCATGTAGAGTAGCTTGATGGGGGATCTCATGGAGGGAAGGTGGGAGGCAGGCTGCTCCCATGTGGTGAGAACAGTGGGAACAGCTGGGCTTCCCTCCTTCATAGCCAGTGATGGGCAAGTCCGCATGATCAGCTGTGGAGCAGACAAGAGCATCTACTTCCGCACTGCGCAGAAGGTGAGGGCGCTGGGCTTTCCTGAGAGGGGCGGGACAGGGCGGGGTCTGCCATTCCCTGCCTAAGGTTACAAGAGGTGAAGGGAGGCGCAAGTAGGGCTCTTGGGGCCTGGTGAGGCATTTGGGTGTGGGCCTGCCCACATGCTCCACCCCTGCAGTCTGGAGATGGAGTGCAGTTCACACGGACACACCACGTGGTGCGGAAGACGACCCTCTATGACATGGATGTGGAGCCCAGCTGGAAGTACACGGCTATCGGCTGCCAGGACCGAAATATTCGGTGGGCGTCCCCTCCTCAGACTCTGCCCACATTCCTTCATCTCCCTACGGGGTCAGCTCTGTGCAGCTAAGTTCCCACATCTGTCGTTCTGTACAGGACTTTGTACCCCCTTGAGCCTACAGTACTTTGCTTCACCCAAGAGGTGGTAGCCTGTTTGCTGCTGGGGGTAGCTCCCAGAGAGTGTAGACTGGGAGTGAAAGCTGGCATTTCCATCCCCCAGGCGTGTTCCACCTTCACCGCCTCCTCATGAGAAAGAGACTATGTTTCTTACAGGATATTTAACATCAGCAGTGGAAAGCAGAAGAAGCTGTTTAAAGGGTCACAGGGTGAGGACGGCACACTCATTAAGGTAAGGACCCAGAGGGGGTACTGGACAGGGGCTCGGGGACAGAGTGGTGCTGGGTGGGAGGGACTGGTACTTCCCATGTCCTCCAGCTGCACACCCTGCTACTCCTCAGGTGCAGACAGACCCCTCAGGGATCTACATTGCCACCAGCTGTTCTGACAAGAATCTCTCCATTTTTGACTTCTCCTCAGGCGAGTGCGTGGCCACCATGTTTGGCCACTCAGGTGAGTGTAGCCTGAATCCCCGAGTAGAAGCTGATACCTGCGTAAACCTGAGTGAGTTCCACCCCTGGAACTTCACTCTTCTATTAGTTTCTTGGGACCCGCAGAGCTACCTATCCCTACCCTGCAGCCAACCCCCGTGTCCACTGTTGGGATGGAGAGGACTTGGTTGGGAATTTAAGGTGGCTTATAGACCGTATTCTTTGTTCTTCACAGAGATTGTCACTGGCATGAAATTTAGTAATGATTGTAAACATCTCATCTCTGTGTCTGGGGACAGGTGAGCAGAAGCCAGCTTCCCTGAGAGGCAGATTCTTACTCTGCCACAGCACCCTGCCCTCCCCTCTCTCCATTTCAGTGATGTCTCTGGGAAGTGGGGTTAACAGGGATAGCTTTTGGCTGTGCTTGACCTGAAGTGGAGGGTGGCTCTGGTCTCCTTGCCATCCATGGATAAGGGGAACGAATGGCGCTAGCCATTCTACCTGCCCCTCCTTCAGCCAACTGTGTGGCTTTACCCCAGCTGCATATTTGTGTGGCGCCTGAGCTCTGAGATGACCATCAGCATGAGGCAGCGTCTGGCCGAGTTGCGCCAGCGTCAGCGGGGCGGCAAGCAGCAAGGACCATCCTCTCCCCAAAGGGCTTCTGGACCCAACCGGTGAGAACAGAATGTGGGCAAGTGATG
Task1_train_20549
Here is a genetic alteration in CAPN3 (calpain 3) on Chromosome 15. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
CAAAACCTAATAACAGAATGACTGTAATTGTACCTATTTTATAGGTGAGAAATCTGAGACAGAAAGGAAGAAATAACTCACCTAAAGTTACACAGGCACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTT
CAAAACCTAATAACAGAATGACTGTAATTGTACCTATTTTATAGGTGAGAAATCTGAGACAGAAAGGAAGAAATAACTCACCTAAAGTTACACAGGCACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCGTGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTT
Task1_train_20550
This mutation is located in gene CAPN3 (calpain 3) on Chromosome 15. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
AAACCTAATAACAGAATGACTGTAATTGTACCTATTTTATAGGTGAGAAATCTGAGACAGAAAGGAAGAAATAACTCACCTAAAGTTACACAGGCACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTTTG
AAACCTAATAACAGAATGACTGTAATTGTACCTATTTTATAGGTGAGAAATCTGAGACAGAAAGGAAGAAATAACTCACCTAAAGTTACACAGGCACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCATTCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTTTG
Task1_train_20551
A variant on Chromosome 15 in gene CAPN3 (calpain 3) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
GTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTTTGCTCATGCTGTCTGTCTGCCTGACATGCCTTTTTTGTTCCTATCTGAACCTCTGCTCAGGTGTCACTTCCTTCAATCTTTCTCATGACTGATTTCCTCTCACTGAGAGCAGAAATCCTTCCTGTTCATCTTTGAGGCCCCCTCACCAAGCTCAGGCCAGTCCCATAGTGGGTACTCAGCTGATGCTGGTGAGTGAAAACCCACGCCCAAGGGCCTTGACCAGTGAGACAGGATAGGCCTGCGTTCCCAGGCAGGG
GTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTTTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTTTGCTCATGCTGTCTGTCTGCCTGACATGCCTTTTTTGTTCCTATCTGAACCTCTGCTCAGGTGTCACTTCCTTCAATCTTTCTCATGACTGATTTCCTCTCACTGAGAGCAGAAATCCTTCCTGTTCATCTTTGAGGCCCCCTCACCAAGCTCAGGCCAGTCCCATAGTGGGTACTCAGCTGATGCTGGTGAGTGAAAACCCACGCCCAAGGGCCTTGACCAGTGAGACAGGATAGGCCTGCGTTCCCAGGCAGGG
Task1_train_20552
Located on Chromosome 15, this mutation impacts CAPN3 (calpain 3). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
CTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTTTGCTCATGCTGTCTGTCTGCCTGACATGCCTTTTTTGTTCCTATCTGAACCTCTGCTCAGGTGTCACTTCCTTCAATCTTTCTCATGACTGATTTCCTCTCACTGAGAGCAGAAATCCTTCCTGTTCATCTTTGAGGCCCCCTCACCAAGCTCAGGCCAGTCCCATAGTGGGTACTCAGCTGATGCTGGTGAGTGAAAACCCACGCCCAAGGGCCTTGACCAGTGAGACAGGATAGGCCTGCGTTCCCAGGCAGGGAGTTCCTAAAAGCCCTTTCTTGGGCCAGACATGG
CTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTAGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTTTGCTCATGCTGTCTGTCTGCCTGACATGCCTTTTTTGTTCCTATCTGAACCTCTGCTCAGGTGTCACTTCCTTCAATCTTTCTCATGACTGATTTCCTCTCACTGAGAGCAGAAATCCTTCCTGTTCATCTTTGAGGCCCCCTCACCAAGCTCAGGCCAGTCCCATAGTGGGTACTCAGCTGATGCTGGTGAGTGAAAACCCACGCCCAAGGGCCTTGACCAGTGAGACAGGATAGGCCTGCGTTCCCAGGCAGGGAGTTCCTAAAAGCCCTTTCTTGGGCCAGACATGG
Task1_train_20553
A variant on Chromosome 15 in gene CAPN3 (calpain 3) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy
CTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTTTGCTCATGCTGTCTGTCTGCCTGACATGCCTTTTTTGTTCCTATCTGAACCTCTGCTCAGGTGTCACTTCCTTCAATCTTTCTCATGACTGATTTCCTCTCACTGAGAGCAGAAATCCTTCCTGTTCATCTTTGAGGCCCCCTCACCAAGCTCAGGCCAGTCCCATAGTGGGTACTCAGCTGATGCTGGTGAGTGAAAACCCACGCCCAAGGGCCTTGACCAGTGAGACAGGATAGGCCTGCGTTCCCAGGCAGGGAGTTCCTAAAAGCCCTTTCTTGGGCCAGACATGG
CTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTCTGGTTCAGTATCTAATTCCAACTTCTGTCTCAGATGCCTAATGTGGCATGGCTGAATGAGTCAACATATAACCTGTACAGTAAGTCCTCACTTAACATCATTGATAGGTGCTTGTAAACTGTGACTTTAACGAAAACATACCGTGTGCTGTAGGGACTTAACTCTTGTTTATATCAGTTAGCCTGGTTTCACTATACAGTACATCATTTTGCTTAAAGTCACAGCTTACGAGAACCTATCGATGATGTTAAGTGAGGATTTTCTCTGCTCAGGTGCACTTTTTTTTTTTTTTAAGACGGAGTCTCTTTCTGTCACCTGGGCTGGAGTGCAGTGGCGTGATCTGGGTTCACTACAACCTCTGCCTCCTGGGTTCAAGCAATTCTTCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCGCCACACCCGGCTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATTGTTGGCCATGCTGGTCTCGAACTCCTGACCTCATGTGATCCACCCGCCTCGGCCTCCCAAAGTGCAGAGATTAGAGACGTGAGCCACATGGCCCAGCAGGACCACTTTTTAGCAGATTCAGTCCCAGTGTTCATTTTGTGGATGGGGAGAGACAAGAGGTGGCAAGGTCAAGTGTGCAGGTAGAGACAGGGATTTTCTCAAATGAGGACTCTGCTGAGTAGCATTTTCCATGCAGACATTTCCAATGAGCGCTGACCCAAGAACATTCTAAAAAAGATACCAAATCTAACATTGAATAATGTTCTGATATCCTAAAATTTTAGGACTAAAAATCATGTTCTCTAAAATTCACAGAATATTTTTGTAGAATTCAGTACCTCCCGTTCACCCTAACTAGCTTTTTTGCAATATTGTTTTCCATTCATTTGATGGCCAGTAGTTGGGTGGTCTGTATAACTGCCTACTCAATAACATGTCAGCAGTTCTCAGCTTCTTTCCAGTGTTCACCTTACTCAGATACTCCCTTTTCATTTTCTGGCAACACCAGCACTTCATGGCAACAGAAATGTCCCTAGCCAGGTTCTCTCTCTACCATGCAGTCTCTCTTGCTCTCATACTCACAGTGTTTCTTCACATCTATTTTTAGTTTTCCTGGCTCAAGCATCTTCAGGCCACTGAAACACAACCCTCACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAACTTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCTCAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCACTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCACTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCACAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTAGTCTGGAAGAGACCTCCGGTGAGTAGCTTCCTGCTTGCTGGCTGGGTTTTCCCCCCACGGAGGAGTCCTCTCACTCAGCACCTCCGGCAGCTCAGCTGTGCACATGGGCACTGGGGGAAGGATCCTGGCAGCAGCTCTGCTGGGCTCTGTCTTTAAGTGTGAAGCAGGGAGGAGAGGAACAGGTCTCAGATATTTCACCAAATCTCAGCAAAATCCAGAGGGAGAGCGCAGGAGGTGGGGCTGATTCTTATGCTCTGGCTCTTTCTCTCTGAAAAAAAAAAAAAAATCTTGCTTTTTATAAAAGTGGGTGGAACTCAGTTTAATTCATCCTGTAAAAATAAATATTCCTTTCTCAGAACAAATTCCAGACAGCCCAGATGTACCTGTTCGTTTTAAATATTATTCATCTTTGTAAGATTATTTCAGTTTCTCTGGCTAAAATCATGATGTTATTCTTCTTTAATTTACCAATGGCCATATCTTTCTGAAACACAGAAACCCTAGAAAGAGAAGAGTCATAGGCAAGGAATATTTTTTCATGCATAAAATGTTGGGGTTAAAGAGAGAGAGACCTAGCAATCGCTTTTGTCCACCTACCTCACCTCATAAGTGAGGAGTCAAGGCACACTAGAGTGAAATATATCTAGTGGGCACATGACAGAGCCCGGATTAAAACTTTCTGTTTTAGGAAACTCTCCCAGCCTCTGGGTTTCATTTACAGTGATCGCCAGGAGGGAAATCACATTCCCCTGGCTCACCTCTCTGATCATCCCTCCAGTGTGACTCTTGTTCTTAATTCGAGAAATATTTATTGAGCATCTACTAGTGCCAGCACTGGGCAAGCAACTGGGGGGACAGCAGTGAGTAAGAAAGACCAAAATTCCAGCTGTCTTGGAACCTAGGGTCCTGAAGGGAAGATGGGCATTGAACAAGAGTGACATTGTCAGGAGACGATGTTCTGGGTGCCACAGGATCATGTGGCAAGGAGAGCTAACCTGGTCCAGGGAGACAAACCCTCTCTGAGGAAATGATGACAAGCTGAGACCCAATACTATTGATTAGCCATGGTTTTCTTTAACCTAAGGTGGGCCAGGCATGGTGGCTCATGCCTATAAACCCAGCATTTTGGAAGGCCCAGGCTGGAGGATTGCTTGAGCCCAAGAGTTAGAGACCAGCCTGGGCAACAGGGTGAAAACCTATCTCTTTTGTACTAAAAATTCAAAAAATTATCCAGGCATGGTGGCACATGCCTGTGGTCCTAGCTACTCAGAGGCTGAGGTGGGAAGATCACTTGAACTCGGGGAGTTGAGGCAGCAGTGAGCCGAGATCATGCCACTGCACTCCAGGCTGGGTGACAGGAGTGAGACCCAGTCTCAAACAACAACAATAACAACAACAAACCTGAGGTGGAGTACTAGACAACCCTGTATATTCCATAGGGGCTCTTCTTGGTTCTATGGTAAGGCCCATAACTGTCCTGAAGGCCTTCAGTTTAGAAGATAACACTACTCTGCTATCAGAGTAGTTGGACATGTCACAACCCCCTGCTGAAATATCTTCAGTGACATCCCTCTCTCGGCCCCCACTGCCTTCAGGACAAGTCCAAACTCCTTAGCCAAGCCATAGGCCCTTCTCAGCTGGTCCCTGCCTACCTGTCCAGGCCCATGTCCATCCTCTTTCCCCAGATCCTGACACACCAGCAGTGCTTGGACATTTAGCTGCTCTGTAGTTCCAAGTCTTCTCACACCGGAGGCCTTTGCTCATGCTGTCTGTCTGCCTGACATGCCTTTTTTGTTCCTATCTGAACCTCTGCTCAGGTGTCACTTCCTTCAATCTTTCTCATGACTGATTTCCTCTCACTGAGAGCAGAAATCCTTCCTGTTCATCTTTGAGGCCCCCTCACCAAGCTCAGGCCAGTCCCATAGTGGGTACTCAGCTGATGCTGGTGAGTGAAAACCCACGCCCAAGGGCCTTGACCAGTGAGACAGGATAGGCCTGCGTTCCCAGGCAGGGAGTTCCTAAAAGCCCTTTCTTGGGCCAGACATGG
Task1_train_20554
A mutation found in LOC126862115, CAPN3 (BRD4-independent group 4 enhancer GRCh37_chr15:42677734-42678933| calpain 3) on Chromosome 15 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy
TAATAGCTACTGCGGCCGGGCGCGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGTCTATCTACTGTTATTCTTACCTGGTCATTTCCTTTTTGTTTCACAGGAAATTTGCGAGAATCCCCGATTTATCATTGATGGAGCCAACAGAACTGACATCTGTCAAGGAGAGCTAGGTAGGAAAGTGCCTCAGGTCAGATCCTGCCAGATGATCAAGGGGTGATTACAAGGTGTGATCCCCTTCCAGGAGGTAAAGGGACAATCTGTGCTTGCTTCCAGTAACTTTTTGGAAGATTTTTTATAACAGTTGCTTTATGGTCGTTTATCTACATGCTGGCGATTGCTTCATTTCCTCCTACATGCCTCTTTAGCACTCTGCCATGCATCACAGGGGGTATCTGCATCCTGTGGCCTCCTCTCCAGTATCTCAAGGACACTTACATACCCCACTCAGCATGACAAAAGCCCTGCTTTTCACTGTATCGTCTTTCTTGGAAGACAGCTCTGTGACTGTGCACCAAGCATGCCCCTTGGGCATGGAGATTCTAGATACACACACAAAAGGCATCGCCAAGGAAAGCACTTGTAACTGGAACCCTTGTTTAAATTGCCCCAGCATAGCTCCATCTTAAAAGAGTCTTTCCACAAAGATGGCATCCGCCATGTGGATGAGCATCCAATTTTCTCTTTGATTGGTTAGCTTGACTGCTCCATCTGATCTTCCTCTCTCTCGACCTCTTGTTCAGAAAGTATTGTCTTTGGTGTGGACTATAAGCAAGCTCTGTGAAGTAAAATTGGAGAGAACACCAACAGAAACAATTTAAATTTGAGGAAAAGGGGGCACCTAAGACCAAAGGAATTTGGCTTATTTCATTCCAGAAGGGGAGGCTGAGAATAAATCAGATGAATATCTGGGTTCCTGCACCTGAGGGAAGGCTTCCTGCAGAGCCCTGGGCATAATAATCTGGGACCTTCAAACCAATAACCTCTTTCCAAGGAAAGACTGGCTGCTTCCAAGGAGGGTAGGGGAGAGTGGCTGCAGGCAGCTCTCAGTCTCCCCTGCACACTCTCAGTTGCATTTCACTTAACCCATCCTCCTTAGAAGGCAGCTCTGTGACCAGGTACACCCCCTATTATATATATATATACACACACAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAAGAGAGCAAAGTGTTACCTCCAACTACATACAGTACTCTGTCAGAAAAGAGGTTCAGAGAATAAGAAAACGTCCCGAGCTCATTCCGTTGCCAGCAATGTCTTACTGCCCCCTATAGACGGGTTCCAGGGCAGCTGCCTACCTGGCCTTCCTTCCAATACAAATCATCTTGGTGGATGGTTCTCTGAGGCTCAGTCTTCGCTGAAGTCAGAAGAGGAATTGGACTCACATTGCAAAGGCACAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGGAGTGGCTGGCTGGGATTGGGGCTTTTTCTTCCCAGGAGGAGCAGGAGTGCTCACGATCTGTGCCCTGTGTCTGCCTGCAGGGGACTGCTGGTTTCTCGCAGCCATTGCCTGCCTGACCCTGAACCAGCACCTTCTTTTCCGAGTCATACCCCATGATCAAAGTTTCATCGAAAACTACGCAGGGATCTTCCACTTCCAGGTGAGGTAATGAGAGTGTAGTTAAGAGGGCCAGCGGCAGGCCACCCACCGCTGGTCTCCTGGCCTTGACTTCCCAGAAGCTGGAGGAAACTTCCCACCCATCTACCCGCAGCGGCAACAGTCGGCATGGACCCCCTTAAGGCTTCAAGCCTGGGAGGAAGCAGTTGCTTATCTCTGGCTCCCTAATCCCTCCCCCACCACCTTCCACTATGTCCCAGAAAGACAGGAAGACATCCTGTTTACTGTGGGTCTATTTTTGTCTTTGCAGCTGTCTGGCTGCTTTTATTGCCTGCAGCCCTTCTCAAGTAGGTCCCTAAGATATTAGCACTGTGACACCACAGGACCCTTCAGGTTGTACAGGAACCCCTGTCCAGGGCTCCTGTATACTTCTTCCTCTCTAAGGCATGGCGGTACCAAGGCTATCACTCCTCTCTTCCAAGCCCTGGAAGAAGAGTCTGCTTAACCTGGGGATCAGGCTTCTTGTTTGCCCTAGAACTGAATCTGATGGTTCTAGAATCCATCCAGCTACTGGAAATTTTCTGGGTCCCAGTCACCTTGGCATAGAGCTGGTGCTAGAGCAGAACCAAACTGAATTCTACCTGTGAGGGTCTCGTAGCTTCCGGGATGCTGGGGAGTCAGCCTGTCTCCAGCTTCAAAGGCTCCCTCATGTCCCAGGATGACCCACATTATCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGT
TAATAGCTACTGCGGCCGGGCGCGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGTCTATCTACTGTTATTCTTACCTGGTCATTTCCTTTTTGTTTCACAGGAAATTTGCGAGAATCCCCGATTTATCATTGATGGAGCCAACAGAACTGACATCTGTCAAGGAGAGCTAGGTAGGAAAGTGCCTCAGGTCAGATCCTGCCAGATGATCAAGGGGTGATTACAAGGTGTGATCCCCTTCCAGGAGGTAAAGGGACAATCTGTGCTTGCTTCCAGTAACTTTTTGGAAGATTTTTTATAACAGTTGCTTTATGGTCGTTTATCTACATGCTGGCGATTGCTTCATTTCCTCCTACATGCCTCTTTAGCACTCTGCCATGCATCACAGGGGGTATCTGCATCCTGTGGCCTCCTCTCCAGTATCTCAAGGACACTTACATACCCCACTCAGCATGACAAAAGCCCTGCTTTTCACTGTATCGTCTTTCTTGGAAGACAGCTCTGTGACTGTGCACCAAGCATGCCCCTTGGGCATGGAGATTCTAGATACACACACAAAAGGCATCGCCAAGGAAAGCACTTGTAACTGGAACCCTTGTTTAAATTGCCCCAGCATAGCTCCATCTTAAAAGAGTCTTTCCACAAAGATGGCATCCGCCATGTGGATGAGCATCCAATTTTCTCTTTGATTGGTTAGCTTGACTGCTCCATCTGATCTTCCTCTCTCTCGACCTCTTGTTCAGAAAGTATTGTCTTTGGTGTGGACTATAAGCAAGCTCTGTGAAGTAAAATTGGAGAGAACACCAACAGAAACAATTTAAATTTGAGGAAAAGGGGGCACCTAAGACCAAAGGAATTTGGCTTATTTCATTCCAGAAGGGGAGGCTGAGAATAAATCAGATGAATATCTGGGTTCCTGCACCTGAGGGAAGGCTTCCTGCAGAGCCCTGGGCATAATAATCTGGGACCTTCAAACCAATAACCTCTTTCCAAGGAAAGACTGGCTGCTTCCAAGGAGGGTAGGGGAGAGTGGCTGCAGGCAGCTCTCAGTCTCCCCTGCACACTCTCAGTTGCATTTCACTTAACCCATCCTCCTTAGAAGGCAGCTCTGTGACCAGGTACACCCCCTATTATATATATATATACACACACAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAAGAGAGCAAAGTGTTACCTCCAACTACATACAGTACTCTGTCAGAAAAGAGGTTCAGAGAATAAGAAAACGTCCCGAGCTCATTCCGTTGCCAGCAATGTCTTACTGCCCCCTATAGACGGGTTCCAGGGCAGCTGCCTACCTGGCCTTCCTTCCAATACAAATCATCTTGGTGGATGGTTCTCTGAGGCTCAGTCTTCGCTGAAGTCAGAAGAGGAATTGGACTCACATTGCAAAGGCACAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGGAGTGGCTGGCTGGGATTGGGGCTTTTTCTTCCCAGGAGGAGCAGGAGTGCTCACGATCTGTGCCCTGTGTCTGCCTGCAGAGGACTGCTGGTTTCTCGCAGCCATTGCCTGCCTGACCCTGAACCAGCACCTTCTTTTCCGAGTCATACCCCATGATCAAAGTTTCATCGAAAACTACGCAGGGATCTTCCACTTCCAGGTGAGGTAATGAGAGTGTAGTTAAGAGGGCCAGCGGCAGGCCACCCACCGCTGGTCTCCTGGCCTTGACTTCCCAGAAGCTGGAGGAAACTTCCCACCCATCTACCCGCAGCGGCAACAGTCGGCATGGACCCCCTTAAGGCTTCAAGCCTGGGAGGAAGCAGTTGCTTATCTCTGGCTCCCTAATCCCTCCCCCACCACCTTCCACTATGTCCCAGAAAGACAGGAAGACATCCTGTTTACTGTGGGTCTATTTTTGTCTTTGCAGCTGTCTGGCTGCTTTTATTGCCTGCAGCCCTTCTCAAGTAGGTCCCTAAGATATTAGCACTGTGACACCACAGGACCCTTCAGGTTGTACAGGAACCCCTGTCCAGGGCTCCTGTATACTTCTTCCTCTCTAAGGCATGGCGGTACCAAGGCTATCACTCCTCTCTTCCAAGCCCTGGAAGAAGAGTCTGCTTAACCTGGGGATCAGGCTTCTTGTTTGCCCTAGAACTGAATCTGATGGTTCTAGAATCCATCCAGCTACTGGAAATTTTCTGGGTCCCAGTCACCTTGGCATAGAGCTGGTGCTAGAGCAGAACCAAACTGAATTCTACCTGTGAGGGTCTCGTAGCTTCCGGGATGCTGGGGAGTCAGCCTGTCTCCAGCTTCAAAGGCTCCCTCATGTCCCAGGATGACCCACATTATCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGT
Task1_train_20555
This mutation occurs in CAPN3 (calpain 3) on Chromosome 15. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
GGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGGATTTTTTAAATTTTTTTGAAACAAGGTCTCACTCTGTAATGCAGGCTGGAGTGCAGTGGTGCAGTCACGGCTCACTGCAGCATTGACCTCCTGGGTTCAAGGTGCTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACATGCGGGCATCACCATGCCCAGTTAATTTTTGTATTTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCCAGACTGGTCTCGAACTCTTGGGCTCATGCAATCCACCAGCCTTGGCCTCCCGAAGCGCTGGGATTGCCGGTGTGAGCCACCACACCGGCAGCTGCTAATGGCTTTAATGCAGCCCTTCCTCAACGTTCAGGATGTAGTGGAAAGAGCTCTCAGGAAGTGGGGATAGCTGGGTTTCAATCCCAGTGCTTCTGGCTCTCTGTGGTCTTGGGTGGGTCACTTAGCCTCTTGAGCTCAGTTTCTTCATTATGAAGAAAGGGAATCATTGTTTCCATCCCATGAGCTCATAGGGTTAATGTGGAATTGATGAAAGAACATCACAGCATCCAAGAGGTAAAGTTCTGGTGGCAGTGGTACCTGGGTTTTGTTCCCTGGAACTCTGTGACCCCAAATTGGTCTTCATCCTCTCTCTAAGGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCACAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACATGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTCCATTGATGTAAGTCTGGGGTGTGGGGCACAGGGTGGGGAGCTCCAAGTGTCAGGAAGCCTTTTACCCAATGAAGGGCAGCATAGAGCTTTTGTGTGGGACAGAGCGAATGTTTTGTTTGAGGAAGCAGGAACTGGCTCTCAACTTTGAGGACTGGGAATTTCTCAAGGGAGAACAGTTCTTCCGGATTTTCAATAAAGACACTGGTCAAGGACATTTCAAGCCCTGGAATGTCAGTGGAAATCAGTCCAGAGGCCTGTGTCAGTGGAGGCCTCCCTTGCTGGTGCTCCTCAGTCTCAGCACGCTCCCATTAAGCTGGCCACGTACTTGGCTGTGGACCTGAGCCCACCATTTCCCTAAGAAAGCCTCCCAGTCACTGGGCTTTCACCACACCTCCCCGCTTGAGACGTGGGCTTTGTGTTGTTACCTGGGAGAAGCTAAGCCTGCAGCACCTTTCAGTGCAAAGAAATGCTGTGAACTGAGACAGGAGCCAAGGGTAGGGAGATGGCCGCCCATGGCCAGGCCTCCTTCAGGGGGCATGCCTTCCCTGAGGGCTGCTCAGTATATTGATATGATAATCTTAGTGGTTTCCATTGGGGAGGATGGGGCTGAAGCTGAATTCCTGCCCCTTCTTCTCCCAACACGCCCAATGGACAGCTTGGAAGGTCAGTTAGCACACAACACCATGGATGAACTTTTTTTCTGTATCACTTTTCTCCGTCTTTCCTCCATTCGTGCTCTGTTGATCTCTCCTCTCTCCCTTTGTCTGTCCCATCTCTTTCTCCTCTCTCCTTCCCTTTCCACCCTTCTGTGTTTGTTCTCTCCCTCCCCTGTGTTGTTCCCTACATTCTCCATCGGGCCTCAGGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTGCTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGGTGTGTACACCTCCGATTATCAGAACTGACCATCCCTCCAACCCACATGACCCCGCCCTATTAGTGTCAGACTCCCCTCAGCAGCCAGGGCCTTACCCACACACCCCCACCTGGCACCTCCCAAGGGTCTGGGTTGAAATAACTTGCTCAGCCAAGGCTCCTGAAGAGGGTGCAAGAACCAGGATTTTGGAGGGAATCTCTGCTGGAGTTTCTGCATATTCCATGGTCCAGGCAGTTCCTCTCATAACGAACTATCAGACAGAAATACTTGTAAAGATACTTCATTTATTTTGAAATATTTTTCCTCTTCTAATGTATTCATTTATTCATTCAACACTTATTTTTGAGCTCCTACTATGTTCCAGGCACTCCTCTAGCAAACAAAGCAAATTCTCTCCTCTTTTTCAATATTTGTGGAAAAAGCAAGGTCTCCCTCTTGTAGAGTTTATATTCTAGTATTTTCATAAGTTATACCTGCTCACTGGAGAATACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCCTCAGCCTCCCGACATAGCTGGGATTACAGGCACACACCACCACACATGGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTGGAATGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACCACA
GGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGGATTTTTTAAATTTTTTTGAAACAAGGTCTCACTCTGTAATGCAGGCTGGAGTGCAGTGGTGCAGTCACGGCTCACTGCAGCATTGACCTCCTGGGTTCAAGGTGCTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACATGCGGGCATCACCATGCCCAGTTAATTTTTGTATTTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCCAGACTGGTCTCGAACTCTTGGGCTCATGCAATCCACCAGCCTTGGCCTCCCGAAGCGCTGGGATTGCCGGTGTGAGCCACCACACCGGCAGCTGCTAATGGCTTTAATGCAGCCCTTCCTCAACGTTCAGGATGTAGTGGAAAGAGCTCTCAGGAAGTGGGGATAGCTGGGTTTCAATCCCAGTGCTTCTGGCTCTCTGTGGTCTTGGGTGGGTCACTTAGCCTCTTGAGCTCAGTTTCTTCATTATGAAGAAAGGGAATCATTGTTTCCATCCCATGAGCTCATAGGGTTAATGTGGAATTGATGAAAGAACATCACAGCATCCAAGAGGTAAAGTTCTGGTGGCAGTGGTACCTGGGTTTTGTTCCCTGGAACTCTGTGACCCCAAATTGGTCTTCATCCTCTCTCTAAGGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCACAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACAGGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTCCATTGATGTAAGTCTGGGGTGTGGGGCACAGGGTGGGGAGCTCCAAGTGTCAGGAAGCCTTTTACCCAATGAAGGGCAGCATAGAGCTTTTGTGTGGGACAGAGCGAATGTTTTGTTTGAGGAAGCAGGAACTGGCTCTCAACTTTGAGGACTGGGAATTTCTCAAGGGAGAACAGTTCTTCCGGATTTTCAATAAAGACACTGGTCAAGGACATTTCAAGCCCTGGAATGTCAGTGGAAATCAGTCCAGAGGCCTGTGTCAGTGGAGGCCTCCCTTGCTGGTGCTCCTCAGTCTCAGCACGCTCCCATTAAGCTGGCCACGTACTTGGCTGTGGACCTGAGCCCACCATTTCCCTAAGAAAGCCTCCCAGTCACTGGGCTTTCACCACACCTCCCCGCTTGAGACGTGGGCTTTGTGTTGTTACCTGGGAGAAGCTAAGCCTGCAGCACCTTTCAGTGCAAAGAAATGCTGTGAACTGAGACAGGAGCCAAGGGTAGGGAGATGGCCGCCCATGGCCAGGCCTCCTTCAGGGGGCATGCCTTCCCTGAGGGCTGCTCAGTATATTGATATGATAATCTTAGTGGTTTCCATTGGGGAGGATGGGGCTGAAGCTGAATTCCTGCCCCTTCTTCTCCCAACACGCCCAATGGACAGCTTGGAAGGTCAGTTAGCACACAACACCATGGATGAACTTTTTTTCTGTATCACTTTTCTCCGTCTTTCCTCCATTCGTGCTCTGTTGATCTCTCCTCTCTCCCTTTGTCTGTCCCATCTCTTTCTCCTCTCTCCTTCCCTTTCCACCCTTCTGTGTTTGTTCTCTCCCTCCCCTGTGTTGTTCCCTACATTCTCCATCGGGCCTCAGGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTGCTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGGTGTGTACACCTCCGATTATCAGAACTGACCATCCCTCCAACCCACATGACCCCGCCCTATTAGTGTCAGACTCCCCTCAGCAGCCAGGGCCTTACCCACACACCCCCACCTGGCACCTCCCAAGGGTCTGGGTTGAAATAACTTGCTCAGCCAAGGCTCCTGAAGAGGGTGCAAGAACCAGGATTTTGGAGGGAATCTCTGCTGGAGTTTCTGCATATTCCATGGTCCAGGCAGTTCCTCTCATAACGAACTATCAGACAGAAATACTTGTAAAGATACTTCATTTATTTTGAAATATTTTTCCTCTTCTAATGTATTCATTTATTCATTCAACACTTATTTTTGAGCTCCTACTATGTTCCAGGCACTCCTCTAGCAAACAAAGCAAATTCTCTCCTCTTTTTCAATATTTGTGGAAAAAGCAAGGTCTCCCTCTTGTAGAGTTTATATTCTAGTATTTTCATAAGTTATACCTGCTCACTGGAGAATACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCCTCAGCCTCCCGACATAGCTGGGATTACAGGCACACACCACCACACATGGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTGGAATGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACCACA
Task1_train_20556
This variant lies on Chromosome 15 and affects the gene CAPN3 (calpain 3). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
GGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGGATTTTTTAAATTTTTTTGAAACAAGGTCTCACTCTGTAATGCAGGCTGGAGTGCAGTGGTGCAGTCACGGCTCACTGCAGCATTGACCTCCTGGGTTCAAGGTGCTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACATGCGGGCATCACCATGCCCAGTTAATTTTTGTATTTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCCAGACTGGTCTCGAACTCTTGGGCTCATGCAATCCACCAGCCTTGGCCTCCCGAAGCGCTGGGATTGCCGGTGTGAGCCACCACACCGGCAGCTGCTAATGGCTTTAATGCAGCCCTTCCTCAACGTTCAGGATGTAGTGGAAAGAGCTCTCAGGAAGTGGGGATAGCTGGGTTTCAATCCCAGTGCTTCTGGCTCTCTGTGGTCTTGGGTGGGTCACTTAGCCTCTTGAGCTCAGTTTCTTCATTATGAAGAAAGGGAATCATTGTTTCCATCCCATGAGCTCATAGGGTTAATGTGGAATTGATGAAAGAACATCACAGCATCCAAGAGGTAAAGTTCTGGTGGCAGTGGTACCTGGGTTTTGTTCCCTGGAACTCTGTGACCCCAAATTGGTCTTCATCCTCTCTCTAAGGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCACAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACATGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTCCATTGATGTAAGTCTGGGGTGTGGGGCACAGGGTGGGGAGCTCCAAGTGTCAGGAAGCCTTTTACCCAATGAAGGGCAGCATAGAGCTTTTGTGTGGGACAGAGCGAATGTTTTGTTTGAGGAAGCAGGAACTGGCTCTCAACTTTGAGGACTGGGAATTTCTCAAGGGAGAACAGTTCTTCCGGATTTTCAATAAAGACACTGGTCAAGGACATTTCAAGCCCTGGAATGTCAGTGGAAATCAGTCCAGAGGCCTGTGTCAGTGGAGGCCTCCCTTGCTGGTGCTCCTCAGTCTCAGCACGCTCCCATTAAGCTGGCCACGTACTTGGCTGTGGACCTGAGCCCACCATTTCCCTAAGAAAGCCTCCCAGTCACTGGGCTTTCACCACACCTCCCCGCTTGAGACGTGGGCTTTGTGTTGTTACCTGGGAGAAGCTAAGCCTGCAGCACCTTTCAGTGCAAAGAAATGCTGTGAACTGAGACAGGAGCCAAGGGTAGGGAGATGGCCGCCCATGGCCAGGCCTCCTTCAGGGGGCATGCCTTCCCTGAGGGCTGCTCAGTATATTGATATGATAATCTTAGTGGTTTCCATTGGGGAGGATGGGGCTGAAGCTGAATTCCTGCCCCTTCTTCTCCCAACACGCCCAATGGACAGCTTGGAAGGTCAGTTAGCACACAACACCATGGATGAACTTTTTTTCTGTATCACTTTTCTCCGTCTTTCCTCCATTCGTGCTCTGTTGATCTCTCCTCTCTCCCTTTGTCTGTCCCATCTCTTTCTCCTCTCTCCTTCCCTTTCCACCCTTCTGTGTTTGTTCTCTCCCTCCCCTGTGTTGTTCCCTACATTCTCCATCGGGCCTCAGGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTGCTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGGTGTGTACACCTCCGATTATCAGAACTGACCATCCCTCCAACCCACATGACCCCGCCCTATTAGTGTCAGACTCCCCTCAGCAGCCAGGGCCTTACCCACACACCCCCACCTGGCACCTCCCAAGGGTCTGGGTTGAAATAACTTGCTCAGCCAAGGCTCCTGAAGAGGGTGCAAGAACCAGGATTTTGGAGGGAATCTCTGCTGGAGTTTCTGCATATTCCATGGTCCAGGCAGTTCCTCTCATAACGAACTATCAGACAGAAATACTTGTAAAGATACTTCATTTATTTTGAAATATTTTTCCTCTTCTAATGTATTCATTTATTCATTCAACACTTATTTTTGAGCTCCTACTATGTTCCAGGCACTCCTCTAGCAAACAAAGCAAATTCTCTCCTCTTTTTCAATATTTGTGGAAAAAGCAAGGTCTCCCTCTTGTAGAGTTTATATTCTAGTATTTTCATAAGTTATACCTGCTCACTGGAGAATACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCCTCAGCCTCCCGACATAGCTGGGATTACAGGCACACACCACCACACATGGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTGGAATGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACCACA
GGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGGATTTTTTAAATTTTTTTGAAACAAGGTCTCACTCTGTAATGCAGGCTGGAGTGCAGTGGTGCAGTCACGGCTCACTGCAGCATTGACCTCCTGGGTTCAAGGTGCTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACATGCGGGCATCACCATGCCCAGTTAATTTTTGTATTTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCCAGACTGGTCTCGAACTCTTGGGCTCATGCAATCCACCAGCCTTGGCCTCCCGAAGCGCTGGGATTGCCGGTGTGAGCCACCACACCGGCAGCTGCTAATGGCTTTAATGCAGCCCTTCCTCAACGTTCAGGATGTAGTGGAAAGAGCTCTCAGGAAGTGGGGATAGCTGGGTTTCAATCCCAGTGCTTCTGGCTCTCTGTGGTCTTGGGTGGGTCACTTAGCCTCTTGAGCTCAGTTTCTTCATTATGAAGAAAGGGAATCATTGTTTCCATCCCATGAGCTCATAGGGTTAATGTGGAATTGATGAAAGAACATCACAGCATCCAAGAGGTAAAGTTCTGGTGGCAGTGGTACCTGGGTTTTGTTCCCTGGAACTCTGTGACCCCAAATTGGTCTTCATCCTCTCTCTAAGGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCACAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACAGGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTCCATTGATGTAAGTCTGGGGTGTGGGGCACAGGGTGGGGAGCTCCAAGTGTCAGGAAGCCTTTTACCCAATGAAGGGCAGCATAGAGCTTTTGTGTGGGACAGAGCGAATGTTTTGTTTGAGGAAGCAGGAACTGGCTCTCAACTTTGAGGACTGGGAATTTCTCAAGGGAGAACAGTTCTTCCGGATTTTCAATAAAGACACTGGTCAAGGACATTTCAAGCCCTGGAATGTCAGTGGAAATCAGTCCAGAGGCCTGTGTCAGTGGAGGCCTCCCTTGCTGGTGCTCCTCAGTCTCAGCACGCTCCCATTAAGCTGGCCACGTACTTGGCTGTGGACCTGAGCCCACCATTTCCCTAAGAAAGCCTCCCAGTCACTGGGCTTTCACCACACCTCCCCGCTTGAGACGTGGGCTTTGTGTTGTTACCTGGGAGAAGCTAAGCCTGCAGCACCTTTCAGTGCAAAGAAATGCTGTGAACTGAGACAGGAGCCAAGGGTAGGGAGATGGCCGCCCATGGCCAGGCCTCCTTCAGGGGGCATGCCTTCCCTGAGGGCTGCTCAGTATATTGATATGATAATCTTAGTGGTTTCCATTGGGGAGGATGGGGCTGAAGCTGAATTCCTGCCCCTTCTTCTCCCAACACGCCCAATGGACAGCTTGGAAGGTCAGTTAGCACACAACACCATGGATGAACTTTTTTTCTGTATCACTTTTCTCCGTCTTTCCTCCATTCGTGCTCTGTTGATCTCTCCTCTCTCCCTTTGTCTGTCCCATCTCTTTCTCCTCTCTCCTTCCCTTTCCACCCTTCTGTGTTTGTTCTCTCCCTCCCCTGTGTTGTTCCCTACATTCTCCATCGGGCCTCAGGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTGCTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGGTGTGTACACCTCCGATTATCAGAACTGACCATCCCTCCAACCCACATGACCCCGCCCTATTAGTGTCAGACTCCCCTCAGCAGCCAGGGCCTTACCCACACACCCCCACCTGGCACCTCCCAAGGGTCTGGGTTGAAATAACTTGCTCAGCCAAGGCTCCTGAAGAGGGTGCAAGAACCAGGATTTTGGAGGGAATCTCTGCTGGAGTTTCTGCATATTCCATGGTCCAGGCAGTTCCTCTCATAACGAACTATCAGACAGAAATACTTGTAAAGATACTTCATTTATTTTGAAATATTTTTCCTCTTCTAATGTATTCATTTATTCATTCAACACTTATTTTTGAGCTCCTACTATGTTCCAGGCACTCCTCTAGCAAACAAAGCAAATTCTCTCCTCTTTTTCAATATTTGTGGAAAAAGCAAGGTCTCCCTCTTGTAGAGTTTATATTCTAGTATTTTCATAAGTTATACCTGCTCACTGGAGAATACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCCTCAGCCTCCCGACATAGCTGGGATTACAGGCACACACCACCACACATGGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTGGAATGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACCACA
Task1_train_20557
Located on Chromosome 15, this mutation impacts CAPN3 (calpain 3). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy
GGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGGATTTTTTAAATTTTTTTGAAACAAGGTCTCACTCTGTAATGCAGGCTGGAGTGCAGTGGTGCAGTCACGGCTCACTGCAGCATTGACCTCCTGGGTTCAAGGTGCTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACATGCGGGCATCACCATGCCCAGTTAATTTTTGTATTTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCCAGACTGGTCTCGAACTCTTGGGCTCATGCAATCCACCAGCCTTGGCCTCCCGAAGCGCTGGGATTGCCGGTGTGAGCCACCACACCGGCAGCTGCTAATGGCTTTAATGCAGCCCTTCCTCAACGTTCAGGATGTAGTGGAAAGAGCTCTCAGGAAGTGGGGATAGCTGGGTTTCAATCCCAGTGCTTCTGGCTCTCTGTGGTCTTGGGTGGGTCACTTAGCCTCTTGAGCTCAGTTTCTTCATTATGAAGAAAGGGAATCATTGTTTCCATCCCATGAGCTCATAGGGTTAATGTGGAATTGATGAAAGAACATCACAGCATCCAAGAGGTAAAGTTCTGGTGGCAGTGGTACCTGGGTTTTGTTCCCTGGAACTCTGTGACCCCAAATTGGTCTTCATCCTCTCTCTAAGGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCACAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACATGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTCCATTGATGTAAGTCTGGGGTGTGGGGCACAGGGTGGGGAGCTCCAAGTGTCAGGAAGCCTTTTACCCAATGAAGGGCAGCATAGAGCTTTTGTGTGGGACAGAGCGAATGTTTTGTTTGAGGAAGCAGGAACTGGCTCTCAACTTTGAGGACTGGGAATTTCTCAAGGGAGAACAGTTCTTCCGGATTTTCAATAAAGACACTGGTCAAGGACATTTCAAGCCCTGGAATGTCAGTGGAAATCAGTCCAGAGGCCTGTGTCAGTGGAGGCCTCCCTTGCTGGTGCTCCTCAGTCTCAGCACGCTCCCATTAAGCTGGCCACGTACTTGGCTGTGGACCTGAGCCCACCATTTCCCTAAGAAAGCCTCCCAGTCACTGGGCTTTCACCACACCTCCCCGCTTGAGACGTGGGCTTTGTGTTGTTACCTGGGAGAAGCTAAGCCTGCAGCACCTTTCAGTGCAAAGAAATGCTGTGAACTGAGACAGGAGCCAAGGGTAGGGAGATGGCCGCCCATGGCCAGGCCTCCTTCAGGGGGCATGCCTTCCCTGAGGGCTGCTCAGTATATTGATATGATAATCTTAGTGGTTTCCATTGGGGAGGATGGGGCTGAAGCTGAATTCCTGCCCCTTCTTCTCCCAACACGCCCAATGGACAGCTTGGAAGGTCAGTTAGCACACAACACCATGGATGAACTTTTTTTCTGTATCACTTTTCTCCGTCTTTCCTCCATTCGTGCTCTGTTGATCTCTCCTCTCTCCCTTTGTCTGTCCCATCTCTTTCTCCTCTCTCCTTCCCTTTCCACCCTTCTGTGTTTGTTCTCTCCCTCCCCTGTGTTGTTCCCTACATTCTCCATCGGGCCTCAGGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTGCTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGGTGTGTACACCTCCGATTATCAGAACTGACCATCCCTCCAACCCACATGACCCCGCCCTATTAGTGTCAGACTCCCCTCAGCAGCCAGGGCCTTACCCACACACCCCCACCTGGCACCTCCCAAGGGTCTGGGTTGAAATAACTTGCTCAGCCAAGGCTCCTGAAGAGGGTGCAAGAACCAGGATTTTGGAGGGAATCTCTGCTGGAGTTTCTGCATATTCCATGGTCCAGGCAGTTCCTCTCATAACGAACTATCAGACAGAAATACTTGTAAAGATACTTCATTTATTTTGAAATATTTTTCCTCTTCTAATGTATTCATTTATTCATTCAACACTTATTTTTGAGCTCCTACTATGTTCCAGGCACTCCTCTAGCAAACAAAGCAAATTCTCTCCTCTTTTTCAATATTTGTGGAAAAAGCAAGGTCTCCCTCTTGTAGAGTTTATATTCTAGTATTTTCATAAGTTATACCTGCTCACTGGAGAATACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCCTCAGCCTCCCGACATAGCTGGGATTACAGGCACACACCACCACACATGGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTGGAATGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACCACA
GGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGGATTTTTTAAATTTTTTTGAAACAAGGTCTCACTCTGTAATGCAGGCTGGAGTGCAGTGGTGCAGTCACGGCTCACTGCAGCATTGACCTCCTGGGTTCAAGGTGCTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACATGCGGGCATCACCATGCCCAGTTAATTTTTGTATTTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCCAGACTGGTCTCGAACTCTTGGGCTCATGCAATCCACCAGCCTTGGCCTCCCGAAGCGCTGGGATTGCCGGTGTGAGCCACCACACCGGCAGCTGCTAATGGCTTTAATGCAGCCCTTCCTCAACGTTCAGGATGTAGTGGAAAGAGCTCTCAGGAAGTGGGGATAGCTGGGTTTCAATCCCAGTGCTTCTGGCTCTCTGTGGTCTTGGGTGGGTCACTTAGCCTCTTGAGCTCAGTTTCTTCATTATGAAGAAAGGGAATCATTGTTTCCATCCCATGAGCTCATAGGGTTAATGTGGAATTGATGAAAGAACATCACAGCATCCAAGAGGTAAAGTTCTGGTGGCAGTGGTACCTGGGTTTTGTTCCCTGGAACTCTGTGACCCCAAATTGGTCTTCATCCTCTCTCTAAGGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCACAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACAGGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTCCATTGATGTAAGTCTGGGGTGTGGGGCACAGGGTGGGGAGCTCCAAGTGTCAGGAAGCCTTTTACCCAATGAAGGGCAGCATAGAGCTTTTGTGTGGGACAGAGCGAATGTTTTGTTTGAGGAAGCAGGAACTGGCTCTCAACTTTGAGGACTGGGAATTTCTCAAGGGAGAACAGTTCTTCCGGATTTTCAATAAAGACACTGGTCAAGGACATTTCAAGCCCTGGAATGTCAGTGGAAATCAGTCCAGAGGCCTGTGTCAGTGGAGGCCTCCCTTGCTGGTGCTCCTCAGTCTCAGCACGCTCCCATTAAGCTGGCCACGTACTTGGCTGTGGACCTGAGCCCACCATTTCCCTAAGAAAGCCTCCCAGTCACTGGGCTTTCACCACACCTCCCCGCTTGAGACGTGGGCTTTGTGTTGTTACCTGGGAGAAGCTAAGCCTGCAGCACCTTTCAGTGCAAAGAAATGCTGTGAACTGAGACAGGAGCCAAGGGTAGGGAGATGGCCGCCCATGGCCAGGCCTCCTTCAGGGGGCATGCCTTCCCTGAGGGCTGCTCAGTATATTGATATGATAATCTTAGTGGTTTCCATTGGGGAGGATGGGGCTGAAGCTGAATTCCTGCCCCTTCTTCTCCCAACACGCCCAATGGACAGCTTGGAAGGTCAGTTAGCACACAACACCATGGATGAACTTTTTTTCTGTATCACTTTTCTCCGTCTTTCCTCCATTCGTGCTCTGTTGATCTCTCCTCTCTCCCTTTGTCTGTCCCATCTCTTTCTCCTCTCTCCTTCCCTTTCCACCCTTCTGTGTTTGTTCTCTCCCTCCCCTGTGTTGTTCCCTACATTCTCCATCGGGCCTCAGGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTGCTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGGTGTGTACACCTCCGATTATCAGAACTGACCATCCCTCCAACCCACATGACCCCGCCCTATTAGTGTCAGACTCCCCTCAGCAGCCAGGGCCTTACCCACACACCCCCACCTGGCACCTCCCAAGGGTCTGGGTTGAAATAACTTGCTCAGCCAAGGCTCCTGAAGAGGGTGCAAGAACCAGGATTTTGGAGGGAATCTCTGCTGGAGTTTCTGCATATTCCATGGTCCAGGCAGTTCCTCTCATAACGAACTATCAGACAGAAATACTTGTAAAGATACTTCATTTATTTTGAAATATTTTTCCTCTTCTAATGTATTCATTTATTCATTCAACACTTATTTTTGAGCTCCTACTATGTTCCAGGCACTCCTCTAGCAAACAAAGCAAATTCTCTCCTCTTTTTCAATATTTGTGGAAAAAGCAAGGTCTCCCTCTTGTAGAGTTTATATTCTAGTATTTTCATAAGTTATACCTGCTCACTGGAGAATACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCCTCAGCCTCCCGACATAGCTGGGATTACAGGCACACACCACCACACATGGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTGGAATGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACCACA
Task1_train_20558
A mutation in CAPN3 (calpain 3), located on Chromosome 15, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
GGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGGATTTTTTAAATTTTTTTGAAACAAGGTCTCACTCTGTAATGCAGGCTGGAGTGCAGTGGTGCAGTCACGGCTCACTGCAGCATTGACCTCCTGGGTTCAAGGTGCTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACATGCGGGCATCACCATGCCCAGTTAATTTTTGTATTTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCCAGACTGGTCTCGAACTCTTGGGCTCATGCAATCCACCAGCCTTGGCCTCCCGAAGCGCTGGGATTGCCGGTGTGAGCCACCACACCGGCAGCTGCTAATGGCTTTAATGCAGCCCTTCCTCAACGTTCAGGATGTAGTGGAAAGAGCTCTCAGGAAGTGGGGATAGCTGGGTTTCAATCCCAGTGCTTCTGGCTCTCTGTGGTCTTGGGTGGGTCACTTAGCCTCTTGAGCTCAGTTTCTTCATTATGAAGAAAGGGAATCATTGTTTCCATCCCATGAGCTCATAGGGTTAATGTGGAATTGATGAAAGAACATCACAGCATCCAAGAGGTAAAGTTCTGGTGGCAGTGGTACCTGGGTTTTGTTCCCTGGAACTCTGTGACCCCAAATTGGTCTTCATCCTCTCTCTAAGGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCACAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACATGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTCCATTGATGTAAGTCTGGGGTGTGGGGCACAGGGTGGGGAGCTCCAAGTGTCAGGAAGCCTTTTACCCAATGAAGGGCAGCATAGAGCTTTTGTGTGGGACAGAGCGAATGTTTTGTTTGAGGAAGCAGGAACTGGCTCTCAACTTTGAGGACTGGGAATTTCTCAAGGGAGAACAGTTCTTCCGGATTTTCAATAAAGACACTGGTCAAGGACATTTCAAGCCCTGGAATGTCAGTGGAAATCAGTCCAGAGGCCTGTGTCAGTGGAGGCCTCCCTTGCTGGTGCTCCTCAGTCTCAGCACGCTCCCATTAAGCTGGCCACGTACTTGGCTGTGGACCTGAGCCCACCATTTCCCTAAGAAAGCCTCCCAGTCACTGGGCTTTCACCACACCTCCCCGCTTGAGACGTGGGCTTTGTGTTGTTACCTGGGAGAAGCTAAGCCTGCAGCACCTTTCAGTGCAAAGAAATGCTGTGAACTGAGACAGGAGCCAAGGGTAGGGAGATGGCCGCCCATGGCCAGGCCTCCTTCAGGGGGCATGCCTTCCCTGAGGGCTGCTCAGTATATTGATATGATAATCTTAGTGGTTTCCATTGGGGAGGATGGGGCTGAAGCTGAATTCCTGCCCCTTCTTCTCCCAACACGCCCAATGGACAGCTTGGAAGGTCAGTTAGCACACAACACCATGGATGAACTTTTTTTCTGTATCACTTTTCTCCGTCTTTCCTCCATTCGTGCTCTGTTGATCTCTCCTCTCTCCCTTTGTCTGTCCCATCTCTTTCTCCTCTCTCCTTCCCTTTCCACCCTTCTGTGTTTGTTCTCTCCCTCCCCTGTGTTGTTCCCTACATTCTCCATCGGGCCTCAGGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTGCTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGGTGTGTACACCTCCGATTATCAGAACTGACCATCCCTCCAACCCACATGACCCCGCCCTATTAGTGTCAGACTCCCCTCAGCAGCCAGGGCCTTACCCACACACCCCCACCTGGCACCTCCCAAGGGTCTGGGTTGAAATAACTTGCTCAGCCAAGGCTCCTGAAGAGGGTGCAAGAACCAGGATTTTGGAGGGAATCTCTGCTGGAGTTTCTGCATATTCCATGGTCCAGGCAGTTCCTCTCATAACGAACTATCAGACAGAAATACTTGTAAAGATACTTCATTTATTTTGAAATATTTTTCCTCTTCTAATGTATTCATTTATTCATTCAACACTTATTTTTGAGCTCCTACTATGTTCCAGGCACTCCTCTAGCAAACAAAGCAAATTCTCTCCTCTTTTTCAATATTTGTGGAAAAAGCAAGGTCTCCCTCTTGTAGAGTTTATATTCTAGTATTTTCATAAGTTATACCTGCTCACTGGAGAATACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCCTCAGCCTCCCGACATAGCTGGGATTACAGGCACACACCACCACACATGGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTGGAATGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACCACA
GGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGTTTGGCATCAAGAAATACCTAAATCAGCACAGTGCCTTCACTGCATAGTTCCCAATCCTGGCCACATTGAATCAGCTGGGGGCACCTGAGAGTGCTGACACCCAGGCCCTGCCCCAGACCTGCTGAGCAGGAGAATGAAAATCTTACATCCTAAGACACTCATGGAGCACCTACTCTACCCATTACTGGGCTGGACTCTGTGGAAGACATGAAGTATATGTAACTCACTTCCAGCTCTCAAAAAGCACCCAGTCCAGTTAGAGACAGATTTACACACCCCAAACACAAAATAGGATGAACAGGCACCCAGATGCAGAGTCCAGGAAATGATGCTGCTTTGGGATTCAAGAACCCCCTGAGGAATGTGGAGGAAGGACACATTTCCTAACAGTAATTTGAGTATGTGACTCTGTGCGTGACGCTTCTGTGCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAATGAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGTAAGCAACACTTTAGAATGTGAGGTGGGGCTAGAGGTGAGAAAGTGGGTTGCAAAATCCAGCCGAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGGATTTTTTAAATTTTTTTGAAACAAGGTCTCACTCTGTAATGCAGGCTGGAGTGCAGTGGTGCAGTCACGGCTCACTGCAGCATTGACCTCCTGGGTTCAAGGTGCTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACATGCGGGCATCACCATGCCCAGTTAATTTTTGTATTTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCCAGACTGGTCTCGAACTCTTGGGCTCATGCAATCCACCAGCCTTGGCCTCCCGAAGCGCTGGGATTGCCGGTGTGAGCCACCACACCGGCAGCTGCTAATGGCTTTAATGCAGCCCTTCCTCAACGTTCAGGATGTAGTGGAAAGAGCTCTCAGGAAGTGGGGATAGCTGGGTTTCAATCCCAGTGCTTCTGGCTCTCTGTGGTCTTGGGTGGGTCACTTAGCCTCTTGAGCTCAGTTTCTTCATTATGAAGAAAGGGAATCATTGTTTCCATCCCATGAGCTCATAGGGTTAATGTGGAATTGATGAAAGAACATCACAGCATCCAAGAGGTAAAGTTCTGGTGGCAGTGGTACCTGGGTTTTGTTCCCTGGAACTCTGTGACCCCAAATTGGTCTTCATCCTCTCTCTAAGGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCACAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACAGGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTCCATTGATGTAAGTCTGGGGTGTGGGGCACAGGGTGGGGAGCTCCAAGTGTCAGGAAGCCTTTTACCCAATGAAGGGCAGCATAGAGCTTTTGTGTGGGACAGAGCGAATGTTTTGTTTGAGGAAGCAGGAACTGGCTCTCAACTTTGAGGACTGGGAATTTCTCAAGGGAGAACAGTTCTTCCGGATTTTCAATAAAGACACTGGTCAAGGACATTTCAAGCCCTGGAATGTCAGTGGAAATCAGTCCAGAGGCCTGTGTCAGTGGAGGCCTCCCTTGCTGGTGCTCCTCAGTCTCAGCACGCTCCCATTAAGCTGGCCACGTACTTGGCTGTGGACCTGAGCCCACCATTTCCCTAAGAAAGCCTCCCAGTCACTGGGCTTTCACCACACCTCCCCGCTTGAGACGTGGGCTTTGTGTTGTTACCTGGGAGAAGCTAAGCCTGCAGCACCTTTCAGTGCAAAGAAATGCTGTGAACTGAGACAGGAGCCAAGGGTAGGGAGATGGCCGCCCATGGCCAGGCCTCCTTCAGGGGGCATGCCTTCCCTGAGGGCTGCTCAGTATATTGATATGATAATCTTAGTGGTTTCCATTGGGGAGGATGGGGCTGAAGCTGAATTCCTGCCCCTTCTTCTCCCAACACGCCCAATGGACAGCTTGGAAGGTCAGTTAGCACACAACACCATGGATGAACTTTTTTTCTGTATCACTTTTCTCCGTCTTTCCTCCATTCGTGCTCTGTTGATCTCTCCTCTCTCCCTTTGTCTGTCCCATCTCTTTCTCCTCTCTCCTTCCCTTTCCACCCTTCTGTGTTTGTTCTCTCCCTCCCCTGTGTTGTTCCCTACATTCTCCATCGGGCCTCAGGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTGCTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGGTGTGTACACCTCCGATTATCAGAACTGACCATCCCTCCAACCCACATGACCCCGCCCTATTAGTGTCAGACTCCCCTCAGCAGCCAGGGCCTTACCCACACACCCCCACCTGGCACCTCCCAAGGGTCTGGGTTGAAATAACTTGCTCAGCCAAGGCTCCTGAAGAGGGTGCAAGAACCAGGATTTTGGAGGGAATCTCTGCTGGAGTTTCTGCATATTCCATGGTCCAGGCAGTTCCTCTCATAACGAACTATCAGACAGAAATACTTGTAAAGATACTTCATTTATTTTGAAATATTTTTCCTCTTCTAATGTATTCATTTATTCATTCAACACTTATTTTTGAGCTCCTACTATGTTCCAGGCACTCCTCTAGCAAACAAAGCAAATTCTCTCCTCTTTTTCAATATTTGTGGAAAAAGCAAGGTCTCCCTCTTGTAGAGTTTATATTCTAGTATTTTCATAAGTTATACCTGCTCACTGGAGAATACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCCTCAGCCTCCCGACATAGCTGGGATTACAGGCACACACCACCACACATGGCTAATTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCTGGAATGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACCACA
Task1_train_20559
This variant lies on Chromosome 15 and affects the gene CAPN3 (calpain 3). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
ACCCTGGATGGCTTCAGGGGAAGGGGGATCCTGAAGCCCAGGGCAGCCTCCAACTCTACCCCTTCCTCCTTTGAAGGATACTAAGGGGTCCAGAAAGGAGGGGCAGGACACTGTTACCCACCCCACATCCCAGCATCCACATTGCTCTCTGATGGTCAGGACAGAGCCTTCTCAGGGAGACCAGCCTGTCTGGAGCTGTGTCTCTTGGCACTCTTAAAGGGCCACTGAAGGTCCGTTCGTGGTCGTGAGGCACACTTTCAGGGAGCAGAGTGGTCTGTGTCTTCACAGAGCCCGGAAAATGAACTAGTATGAACTTTGCCTCCAAGCAGCAGAACTTCTGTTCCCCCGCCCCTAATGGGTTCTCTGGTTACTGCTCTACAGACAATCATTCCGGTTCAGTATGAGACAAGAATGGCCTGCGGGCTGGTCAGAGGTCACGCCTACTCTGTCACGGGGCTGGATGAGGTAAGCCTGGTGGGGCTTGGTGGGGCAAGGGCACCCTCCTGGGTTAACCTCATGAAGTCAGGACTTAGCTGTTGGGGCCCCTTCCCTGTCTGCAGAGCTTGCCTCCAATCAGGACATTCAGTTCAAGGTCCAAGCCACGCCTGGGAGCAGAGGGGCCTGTGAAACTGGTAGAGGTGGATCCTGCCACAGTTGGTGCACAGTTTATCTTTGCTTTTCGTGCTAAAGATGGCAATTTTTCCAACATTTCCAATGAACAAATTGAAATATCACTTAACTTTGCTTTTACAAAGTTGGTTTCATGTGTTCTTGAGCTTCCTGTTCTCTCGTGTTCAGATAGCTACAGTTGTCTCTGGGTAGCCACGGGGACTGGTTCCAGAAGCCCCAACAGTAACAAAATCTGCAGATGCTCAAGTCCCTTCTGTAAAATGGAGTAGTATTTGCATATAACCTATGCACATCCTCCCATATACTTTAAGTCATCTCTGGATTACTTACGATACCTAACACAATGGAAATGCTATGTAAATAGTTATTGCACTGCATTGGGTTTTTTTGGTATTATTTTCTGTTGTTGTATTATTATTTTTTCTTTTTTTGAATATTTTTGATCCACAATTGGTTATATGCCAAAGCCATGGATACGAGAGGCTGACTGTTCTGTTTTGCTCCTTCTGGGACTTCTGGGTTTTCCTGGACCATGTCTGAGACAGGAACGTTGTAAGACCTGTTGCACACAGTTGGGCAGGTTGTGCCCTGTACAGAGGGATGGGCTGAGAGGGGCAGTTGCCTGCATCACCCATTGCAGCAGACTGGAGGGAGTCTGCTTGTTTGTAGTTCCTCAGTCAGCAGGGGCCTTTTGTCTTTCTTTCTTTCTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGTAGTGGCACAGTCTCGGCTCACTGCAATGTCCGCCTCCTGGATTCAAGCGATTTTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCGTGTCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGGTTTCTCCATGTTGATCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCGCCCACCTCGGCCTCTCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGCCAGCAGGGGCCTTTTTTCTAATTTATATGAAGACACCTAATTTATATGTGTTAGCAGGGCCCTACTGTTTATGCCTCACCTCCTCCCCCGAAGCTCATAACGGCAGGATGTTCCTGAGAAAATTGCCTCTTAGAAGATAGAGAGGAGATGGCCAAGCCCTAAGTTAGGCAGACTCAGGAGGAAAGGTCTGACCCACCCCCTGCCATTCCCCAGCACACTTGTGATTAATCTCCTTGGCCAGAGCCAGGCAGAACACCCTCGCGTAAGAGATTTGCCCCCCAGCCCCGTCCCAGCCCTCAGCAAGACAGAAGATTCCCTTTCCAGAGAGGCTGCAGAGCATGAGAGCTCTTTCTGTGTGCTTAAGGTCCCGTTCAAAGGTGAGAAAGTGAAGCTGGTGCGGCTGCGGAATCCGTGGGGCCAGGTGGAGTGGAACGGTTCTTGGAGTGATAGGTAGGTGAGGGGACCCCACGGGATTGGCGGTGGCGGGGAACAGGGTCCGGGACAAGGCTGTGTTGGGAACTGAGCCATGAGAGTATTGAAGATGCTTGGTATAAAATCACCCTCAAAACCAATGATCCGCAGAGAAGAGGGGCACAGGTGTTGGCTCCAGGGAAGGGCCAGGAGTGGAAGCGGGGTGCTGGGGACCCAGAGAGGTTGCTGACAACCATTGGCTGGAAAGGAAGGATTCCAGAAAGCGTGGGGAAGGTCCAGGCAGGAAAAGCGTATGAATGCAGGGTTCTGGGCTAGAGAAGTGACTTCCCTTCTTGGGGTCTTGTGTTGCCTTTCCTGTGAAATGGGAACAGTATTATTAGCACTTACCTTGTGGGCTGATATGAGGAGTAAATGGGACTGTTTTTGGCAAGTGCTGAGCCATTGCTAAGATTCCCTTACCCGTGCTGTCCCTGTATAAAGGCACAAGGGCCCTTTGAAAGAATTTTACTGCTTATCATTGAAAGGAATAGACTGGGGGCAACAAAAATAACAAACATGCGAAGTTATTATGAAGGCTCCAGCACATTTGCAAAACCTCCATGGTCCTACTGGTTCCTGATTACCTCCACTGAATGAGAGGCAATTCATTACTGAATGAGCCATAAGCGCCTCTTATTTCGAGAGGGGGATGGCAGGACTCAGTAGAGGAGAAGGACCGCACCCAGGCAGCCTGGGCCCCTCGGCTCCTGTACTTATATACTGCTGGGTACTTCTTAGCCCAGCATGTAATTACTGGTTCGTTCAGTCATTCGTTTAGCAAATGTTTCTTGGGCACCTACTACATAGGAGGCACAGGTCAAGGCACTGGGGATATTCTGTGAACCCATAGCCTCCCTTGATACACTGTGATTAGGGGCTGATCCTCATGTCCTGACTGCCTCCTGCAGACATTCTCATGCCTTCCTTCACCTATGCACGCTACACCTATCCTTACTTCCTCAGTGCTGACTTCTGCCAGGCCCTAGGCTACCCACCTGGGGATGTAGAAATGTAGAAATGAACACAGACACGTGGGCCCTGTGCCTGTGGGTTTAAGGTCCGGGGAAGGACAGGCAAGCACACACTAATAATTGAGATGAGTGCCACAGTAAGGATCACAAAGAGGGGGCCTCTGCACCTAGTTTGGGTGGGAGGGGAGGCGTAGAGAAAGGTTACCTGGAGGGAGTGACATTGGAACTGTGCTCTGTGCTCTGGGAAGGCCCTCAGTGACTCCTCAGTTGTCTACTTCACTGGCCCAAGTCACCTGCAGGGACGCTTGCTGTGTTCTCCAGCCTCAGAGCTTGGTGTGCAGCCCTGCCCTGCTTACCATGATGCTGCCATCACAGGGGCTGGAGACAAGTGGACCCAACGCTGTTCACTCAAGGAGATTCCCTTTGCTGCATCCCTCCTCCTGGTCTCAGGAATCTCCATGTCCCCTGCAGTGTTCTCTGACTGACTCCAAGCGCTTCCTCCACCCCTTACCTTTCCAGGGAGCACCCAGTTTAGTTGAATTCTCCTCTGTGAGCCTGAAACACACATGCACTTTATTGCCACCATAGTGAGGAGAGAGAGTGTGAAAACTGCCCAGCCTTTAGAAGCACAATGCTTGATTATTTCCCAGCACAGGAAAGGAGATGTTTACAGACTTGGCCTTTTTCCTTAGTAAATCAGAGTTTCTTATTATATGACAGACACTATGCTAACAGCTTTGCATGCATTATTGCATCTGCCCATCCCAGCCCTGTGAACAGGTGACATAATCATTTTCCTTTTGCAATTGAGGAAGCAGAGTCTGACAGAGGTTAAGTGACCTGCCCAAGGTTGCATAGCTAGCCCTATTATTAAACGGAACTCCCAGTTTGTCTATGTCCAGAACCCATTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGCCACCCAGGCTGGAGTGCAATGGCGCGATCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTTC
ACCCTGGATGGCTTCAGGGGAAGGGGGATCCTGAAGCCCAGGGCAGCCTCCAACTCTACCCCTTCCTCCTTTGAAGGATACTAAGGGGTCCAGAAAGGAGGGGCAGGACACTGTTACCCACCCCACATCCCAGCATCCACATTGCTCTCTGATGGTCAGGACAGAGCCTTCTCAGGGAGACCAGCCTGTCTGGAGCTGTGTCTCTTGGCACTCTTAAAGGGCCACTGAAGGTCCGTTCGTGGTCGTGAGGCACACTTTCAGGGAGCAGAGTGGTCTGTGTCTTCACAGAGCCCGGAAAATGAACTAGTATGAACTTTGCCTCCAAGCAGCAGAACTTCTGTTCCCCCGCCCCTAATGGGTTCTCTGGTTACTGCTCTACAGACAATCATTCCGGTTCAGTATGAGACAAGAATGGCCTGCGGGCTGGTCAGAGGTCACGCCTACTCTGTCACGGGGCTGGATGAGGTAAGCCTGGTGGGGCTTGGTGGGGCAAGGGCACCCTCCTGGGTTAACCTCATGAAGTCAGGACTTAGCTGTTGGGGCCCCTTCCCTGTCTGCAGAGCTTGCCTCCAATCAGGACATTCAGTTCAAGGTCCAAGCCACGCCTGGGAGCAGAGGGGCCTGTGAAACTGGTAGAGGTGGATCCTGCCACAGTTGGTGCACAGTTTATCTTTGCTTTTCGTGCTAAAGATGGCAATTTTTCCAACATTTCCAATGAACAAATTGAAATATCACTTAACTTTGCTTTTACAAAGTTGGTTTCATGTGTTCTTGAGCTTCCTGTTCTCTCGTGTTCAGATAGCTACAGTTGTCTCTGGGTAGCCACGGGGACTGGTTCCAGAAGCCCCAACAGTAACAAAATCTGCAGATGCTCAAGTCCCTTCTGTAAAATGGAGTAGTATTTGCATATAACCTATGCACATCCTCCCATATACTTTAAGTCATCTCTGGATTACTTACGATACCTAACACAATGGAAATGCTATGTAAATAGTTATTGCACTGCATTGGGTTTTTTTGGTATTATTTTCTGTTGTTGTATTATTATTTTTTCTTTTTTTGAATATTTTTGATCCACAATTGGTTATATGCCAAAGCCATGGATACGAGAGGCTGACTGTTCTGTTTTGCTCCTTCTGGGACTTCTGGGTTTTCCTGGACCATGTCTGAGACAGGAACGTTGTAAGACCTGTTGCACACAGTTGGGCAGGTTGTGCCCTGTACAGAGGGATGGGCTGAGAGGGGCAGTTGCCTGCATCACCCATTGCAGCAGACTGGAGGGAGTCTGCTTGTTTGTAGTTCCTCAGTCAGCAGGGGCCTTTTGTCTTTCTTTCTTTCTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGTAGTGGCACAGTCTCGGCTCACTGCAATGTCCGCCTCCTGGATTCAAGCGATTTTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCGTGTCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGGTTTCTCCATGTTGATCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCGCCCACCTCGGCCTCTCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGCCAGCAGGGGCCTTTTTTCTAATTTATATGAAGACACCTAATTTATATGTGTTAGCAGGGCCCTACTGTTTATGCCTCACCTCCTCCCCCGAAGCTCATAACGGCAGGATGTTCCTGAGAAAATTGCCTCTTAGAAGATAGAGAGGAGATGGCCAAGCCCTAAGTTAGGCAGACTCAGGAGGAAAGGTCTGACCCACCCCCTGCCATTCCCCAGCACACTTGTGATTAATCTCCTTGGCCAGAGCCAGGCAGAACACCCTCGCGTAAGAGATTTGCCCCCCAGCCCCGTCCCAGCCCTCAGCAAGACAGAAGATTCCCTTTCCAGAGAGGCTGCAGAGCATGAGAGCTCTTTCTGTGTGCTTAAGGTCCCGTTCAAAGGTGAGAAAGTGAAGCTGGTGCGGCTGCGGAATCCGTGCGGCCAGGTGGAGTGGAACGGTTCTTGGAGTGATAGGTAGGTGAGGGGACCCCACGGGATTGGCGGTGGCGGGGAACAGGGTCCGGGACAAGGCTGTGTTGGGAACTGAGCCATGAGAGTATTGAAGATGCTTGGTATAAAATCACCCTCAAAACCAATGATCCGCAGAGAAGAGGGGCACAGGTGTTGGCTCCAGGGAAGGGCCAGGAGTGGAAGCGGGGTGCTGGGGACCCAGAGAGGTTGCTGACAACCATTGGCTGGAAAGGAAGGATTCCAGAAAGCGTGGGGAAGGTCCAGGCAGGAAAAGCGTATGAATGCAGGGTTCTGGGCTAGAGAAGTGACTTCCCTTCTTGGGGTCTTGTGTTGCCTTTCCTGTGAAATGGGAACAGTATTATTAGCACTTACCTTGTGGGCTGATATGAGGAGTAAATGGGACTGTTTTTGGCAAGTGCTGAGCCATTGCTAAGATTCCCTTACCCGTGCTGTCCCTGTATAAAGGCACAAGGGCCCTTTGAAAGAATTTTACTGCTTATCATTGAAAGGAATAGACTGGGGGCAACAAAAATAACAAACATGCGAAGTTATTATGAAGGCTCCAGCACATTTGCAAAACCTCCATGGTCCTACTGGTTCCTGATTACCTCCACTGAATGAGAGGCAATTCATTACTGAATGAGCCATAAGCGCCTCTTATTTCGAGAGGGGGATGGCAGGACTCAGTAGAGGAGAAGGACCGCACCCAGGCAGCCTGGGCCCCTCGGCTCCTGTACTTATATACTGCTGGGTACTTCTTAGCCCAGCATGTAATTACTGGTTCGTTCAGTCATTCGTTTAGCAAATGTTTCTTGGGCACCTACTACATAGGAGGCACAGGTCAAGGCACTGGGGATATTCTGTGAACCCATAGCCTCCCTTGATACACTGTGATTAGGGGCTGATCCTCATGTCCTGACTGCCTCCTGCAGACATTCTCATGCCTTCCTTCACCTATGCACGCTACACCTATCCTTACTTCCTCAGTGCTGACTTCTGCCAGGCCCTAGGCTACCCACCTGGGGATGTAGAAATGTAGAAATGAACACAGACACGTGGGCCCTGTGCCTGTGGGTTTAAGGTCCGGGGAAGGACAGGCAAGCACACACTAATAATTGAGATGAGTGCCACAGTAAGGATCACAAAGAGGGGGCCTCTGCACCTAGTTTGGGTGGGAGGGGAGGCGTAGAGAAAGGTTACCTGGAGGGAGTGACATTGGAACTGTGCTCTGTGCTCTGGGAAGGCCCTCAGTGACTCCTCAGTTGTCTACTTCACTGGCCCAAGTCACCTGCAGGGACGCTTGCTGTGTTCTCCAGCCTCAGAGCTTGGTGTGCAGCCCTGCCCTGCTTACCATGATGCTGCCATCACAGGGGCTGGAGACAAGTGGACCCAACGCTGTTCACTCAAGGAGATTCCCTTTGCTGCATCCCTCCTCCTGGTCTCAGGAATCTCCATGTCCCCTGCAGTGTTCTCTGACTGACTCCAAGCGCTTCCTCCACCCCTTACCTTTCCAGGGAGCACCCAGTTTAGTTGAATTCTCCTCTGTGAGCCTGAAACACACATGCACTTTATTGCCACCATAGTGAGGAGAGAGAGTGTGAAAACTGCCCAGCCTTTAGAAGCACAATGCTTGATTATTTCCCAGCACAGGAAAGGAGATGTTTACAGACTTGGCCTTTTTCCTTAGTAAATCAGAGTTTCTTATTATATGACAGACACTATGCTAACAGCTTTGCATGCATTATTGCATCTGCCCATCCCAGCCCTGTGAACAGGTGACATAATCATTTTCCTTTTGCAATTGAGGAAGCAGAGTCTGACAGAGGTTAAGTGACCTGCCCAAGGTTGCATAGCTAGCCCTATTATTAAACGGAACTCCCAGTTTGTCTATGTCCAGAACCCATTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGCCACCCAGGCTGGAGTGCAATGGCGCGATCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTTC
Task1_train_20560
An alteration has been detected in CAPN3 (calpain 3) on Chromosome 15. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy
GGGAGGCAGAGGTTACAGTGAGCCCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGT
GGGAGGCAGAGGTTACAGTGAGCCCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACAGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGT
Task1_train_20561
An alteration has been detected in CAPN3 (calpain 3) on Chromosome 15. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
CCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAG
CCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCTGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAG
Task1_train_20562
This genomic variant is located on Chromosome 15, within the CAPN3 (calpain 3) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
CCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAG
CCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCTGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAG
Task1_train_20563
A variant on Chromosome 15 in gene CAPN3 (calpain 3) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
CCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAG
CCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCTGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAG
Task1_train_20564
A genetic alteration is present in CAPN3 (calpain 3) on Chromosome 15. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
CCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAG
CCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCTGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAG
Task1_train_20565
This alteration occurs within gene CAPN3 (calpain 3) located on Chromosome 15. Is it associated with a disease or is it a benign variant?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCACAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
Task1_train_20566
Given a variant located on Chromosome 15 and affecting CAPN3 (calpain 3), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCACAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
Task1_train_20567
The gene CAPN3 (calpain 3) is located on Chromosome 15, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCACAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
Task1_train_20568
Gene CAPN3 (calpain 3) on Chromosome 15 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCACAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
Task1_train_20569
The gene CAPN3 (calpain 3) is located on Chromosome 15, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Abnormality of the musculature
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCTCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
Task1_train_20570
A sequence alteration has been identified in CAPN3 (calpain 3) on Chromosome 15. Is it disease-inducing or harmless?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCTCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
Task1_train_20571
A mutation on Chromosome 15 affecting CAPN3 (calpain 3) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
CAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGTGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAACTATGATTGTACCACTGCAGTCCATCCTGGGCAACAGAGCAAGACACTGTCTTAAAAAAAAAGTGCTGGGATTACAGATGTAAGCCACCACACCTGGCCTTCTATTTTTTATGGATATATCATAGCTATATATATTTTTGGGGTACATATGTACCCATATTTTGGGGGTACATATGTACCCATATTTTGGGGGTACATATGATATTTTGATACACATATACAATGTGTAATGATCAAATTAGGGTAATTGAGATACCATCATCTCAAATATGTATCTTTTCTTTGTGTTGGGAACATTACAATTCTTTTCCTCTAGTTATTTTGAAAGATATATAGGCTGGGCGTGGTGGCTTATGCCTGTAATCCCAGCACCTTGGGAGGCTGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCCATCTCTACAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGTAATCCCAGCTGCTCAGCTGGCTGAGGCAGGAGAATCCCTTGACCTCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAATACACACACACACACACACACACACACACACACACACACACACACATATATATACACACATATATATACACACACATATACACACACACACGTCTGTATATATATGTGTGTGTGTATATATACACACACACACTATACTATAAATTCTTGTTTAGCTATGTTTGTCTTACTGTGCTATTGAGCATTAGAGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTTTGTCGCCCAGGCTGGCATACAATGGCGCAATATCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAACTAGGATTACAAGTGCCCGCCATAATGCTCAGCTAATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTCAAACTCCTAGCCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCACCCTGGTGAGCACTAGAGCTTATTTCTTCTATCTAACTGTATTTTTGTATCCATTAGCCACCCTCTTTTCATCCTCCCCTCTCCTTCCCTTCCCAGCCTCTGGTAACCACTGTCTGCTCTCTACTTCCATGACATATGCTTTGTTTTAGCTCTCACATATGAGTGAGAGCATGCGACATTTATCTTTCTGGCCCTGGCACATTTTTGAATCATTGTTAGAAAAGATGATGGTTTGGAGTAGATACATCAGAAGTGACAGCGTTTGCCCTAAAAAGGAAAGACAGGCTCCTCTGGGACCCTGACCAAGTTCCTGTGAACTATTTTATTATTGTGCTGTGTTAGTCCTGGGGTCTTCCGTTCCCAGCCCTCCTCACCTGCTCCCATATGGCTCTCTCTCTTCTTCCAACCTCTCAGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCTCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGG
Task1_train_20572
Given this context: Chromosome 15, gene CAPN3, LOC130056921 (calpain 3| ATAC-STARR-seq lymphoblastoid active region 9300) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
GAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTT
GAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCCGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTT
Task1_train_20573
Located on Chromosome 15, this mutation impacts CAPN3 (calpain 3). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
GCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGA
GCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGACCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGA
Task1_train_20574
Given a variant located on Chromosome 15 and affecting CAPN3 (calpain 3), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
GCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGA
GCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGACCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGA
Task1_train_20575
Assess the clinical impact of this variant on gene CAPN3 (calpain 3), found on Chromosome 15. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
GCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGA
GCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGACCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGA
Task1_train_20576
Consider a variant on Chromosome 15 in gene CAPN3 (calpain 3). Determine its clinical classification and disease relevance.
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
CAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTG
CAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACTGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTG
Task1_train_20577
A variant has been detected on Chromosome 15 in CAPN3 (calpain 3). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
CAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTG
CAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACTGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTG
Task1_train_20578
A variant was discovered in gene CAPN3 (calpain 3), Chromosome 15. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
CAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTG
CAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACTGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTG
Task1_train_20579
Consider a variant on Chromosome 15 in gene CAPN3 (calpain 3). Determine its clinical classification and disease relevance.
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
CAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTG
CAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACTGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTG
Task1_train_20580
A variant on Chromosome 15 in gene CAPN3 (calpain 3) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy
AGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCG
AGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCAGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCG
Task1_train_20581
This variant impacts the gene CAPN3 (calpain 3) on Chromosome 15. Is the change likely to result in a pathogenic outcome?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
TTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTA
TTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGAGCATATTGGGTGATGTAGGGAAGGAAGAAGAATGATGTCAAGATTCCCAGTTGGGGACCTGACAACATTGCAACATAAGACACACAAGAAGATCGGGTGGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCAGAGCCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCACAGGCAACATAGTGACACCTCATCGTTACAAAAAATAAAAAAAAAAATGAGGTGGGAGGATTGCTTGAGCTCGGGAGGTTGAGGCTACAATAAACTGTGATCATGCCACTGCACTCCTGCCTGGGTGACAGAGTGAGACCCTGCCTCAAAAAAAAAAGACACACAAGAGAAAAATATCAGCGTGTTGTTTGTTTTTGGTGGAGTTAATTGTGGGGTTCTAGGGAAAGGAATTTAGCTTGGGACATGGAAAGTTTGAGGTTCCTGTAGAGTGTCCCAGTGAAGATTTGTAATAGAGCATCGGATGCGCATATTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGTTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTA
Task1_train_20582
Gene CAPN3 (calpain 3) on Chromosome 15 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
AAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACA
AAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGTGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACA
Task1_train_20583
The following genetic variant occurs in CAPN3 (calpain 3) on Chromosome 15. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; CAPN3-related disorder
AAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACA
AAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGTGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACA
Task1_train_20584
This gene mutation involves CAPN3 (calpain 3) on Chromosome 15. Is it associated with any clinical condition, or is it benign?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy
AAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACA
AAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGTGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACA
Task1_train_20585
Mutation context: Chromosome 15, Gene CAPN3 (calpain 3). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
AAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACA
AAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGTGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACA
Task1_train_20586
The gene CAPN3 (calpain 3) is located on Chromosome 15, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Abnormality of the musculature
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCTGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
Task1_train_20587
The gene CAPN3 (calpain 3) on Chromosome 15 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCTGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
Task1_train_20588
A mutation in CAPN3 (calpain 3), located on Chromosome 15, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCTGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
Task1_train_20589
Gene CAPN3 (calpain 3), found on Chromosome 15, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCTGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
Task1_train_20590
Located on Chromosome 15, this mutation impacts CAPN3 (calpain 3). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCTGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTT
Task1_train_20591
This sequence variant lies in CAPN3 (calpain 3) on Chromosome 15. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCAGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
Task1_train_20592
This is a variant in CAPN3 (calpain 3), located on Chromosome 15. Is this mutation a likely cause of disease or not?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCAGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
Task1_train_20593
A mutation in CAPN3 (calpain 3), located on Chromosome 15, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCAGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
Task1_train_20594
Here is a mutation in CAPN3 (calpain 3) on Chromosome 15. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCAGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
Task1_train_20595
Here is a genetic alteration in CAPN3 (calpain 3) on Chromosome 15. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
TGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAAGCAGAAGTAAGAAAGATTGCCTAGGGAGGCAGGAAGGGTGAGGTGAGAGGAGAAGAGGCCCAGGACCAGATTCTAGTCACCAACAGCGTTTAAGGGGCAGGTAAGGAAAACAAAACCATCAGCAAAGACTGAGAATGAAAGCCCAGAGAGGAAGGAAAAGCCACACATACAATCAGTACAGCTCCATCTGAATAAAGGTAGCGCCCCCCCCCCCCCCAAATCATTAGAGAAATGCCTGAATCGTGTTTTCTGTTGATATTTCCTAAGCACCTAGATGTAGGGAATAGAAATAAATGGCTCCCTCTGTCTCATCCCCTTCCTGCCCTCTGAGAGGCAGCTGTGAATGCGTGCTTCCTTTCTGGGGGTGCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGCATGCGGGCTGCAGTTGCTGGCATTGCCTTCCGCAGGCTCCTCATCCTCATTCACATCTGAAGCATCTTCCTTTCTGTTTCTTCTCAAGGTTCCCAAAGAGGTATAGCAGCAGCAGCGGCCAGCAGTTGTGTGCAGCACTACCCAGGGGGCCCCGAGTCTGTCTGTGGCTCGTCGAGAAGCTTCCTGGTGGGGTTTGTGGGCAGGACTGTGATAGGAGAGGGCCTTGCCTGTGTTATTTCCACTGCAGAGCAGGTGCCTCAGGGCATTGCATGACCCATGACTACCACCCCCAGGATGTGCACTTTCTCCCTCGCACCAGACACTGCACGTCACACACATGCCTTTGCACACTCACCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCCAAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGGTAAGTGTCCCTGAGTGTGGGGATGACACATTTGCCATTCACTCTGAATCACAACAGAAAAGGAAGAGGAAGTGAGGTAGGGAGGCTATTTAAGCCTTGGGAGTCGGAAGTAGGGAGGTTGAAACTGTGACATGGGTGACCAGGGAGTTGGGAAGGGACCCTTGGAGGTGGCTGTGGCAGGACAGGATGTTCCTCCCGAGGGGCTCATGTGCCCTGGGCTCTCCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCAGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGTGAGTGCTGGCCCAGCTTTCCCACGTGTTTCTAAAAGCTCACATGGCCCACTCCAGAGGTTGAAGGCATGAGGCAGCTAGACACGTCTCCTCCAGGGTCCTTCTGCTGCTCCTGAGCCACTGGCCACATTACCCCCATTCATTCATTCATCCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCATGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAAGAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTGCCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGTGCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCAGGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAGGGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGATAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACACTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAAGCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGGTTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCTTGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTGTCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGTAGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTCACGTGAGTAGAGCAGGCAGGTGCAGGGGTTTTGATGTCCCTGCACTGACACAGTTGTCTGCAGTTC
Task1_train_20596
A variant was discovered in gene CAPN3 (calpain 3), Chromosome 15. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
GCAAAGGCTGAGACAGAACCAGCTTGAGAGCGGAGGCGCAACTCTTGTCTCCTGGTGGCCTTGAGCATTTCACAATAGGGGGATAAAGGATAGGAGCAGAAAAGTGGGGCTGACTTCAGAAATGGGGTCCTCTAGAGCTCACGGGAGGGTGTTAGATTGGAGTGGGAGCTTAGTGGAGGTGAGCCTTAGAGGCAAAAGTCTCCAGACCAATCCAGGGCCCCTCTTCTATCCGGGGGCCCCTCTTCTATCCAGGGCCCCTCTTCTGTCTGGGAGCCCCTCTTCTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGTTTTCCTTTGTGCCTCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGTGAGTACCTCCAAGCCCAGGACGCCCACAGGTGCTTCCTTCTCTCCTGGATTAACTGCTCAGATTACCAATTATTTCATTATTGTTTGGTAGAGGTCACTTTGGACTTTGGTGGAGCCAGGGGATGTGTGCGTAGCACACAAATCCACAAGCCCTTGAGTTTTGGACTGCCACGTCTGCTGGGGGGCTCAGAGGCCTTTTTGCTCTGAGCTGCCCACGGTGGTCCTGATAGCTGAGGTGCAGTATCTGGCCCCCTGTCTTCCTCAGAAAAGCCCCAGCTTCCCATGACATAATAGCACCGACAGGGATTTTACAAACACAGCCAGGTGGAATTTGTTTTGCAAAGTGTCCGCGCCAGGAGCTGCTGTACTCCTGAACCATGACCCTCCTCTCCCTTCCTCCTCAGGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACGTGAGTTGCTCAAACCAAATGGGGGTGGGGTGGGTGGGGAGTCCCGTTGTCTCAAAGCAGCTCCTCACTCTTCTCCATCCCCCCAGACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATGTATCCTTCCTGCCGCCCCTTCCCGACCCTCTGTCATCAGCCCACGGGGGCCAAGGCAACATACAGGGTGCCCAGTCAGGCAAAGGGCCCTAATTTGTGCCCAGGGAAACTTAAGGAGACCCTGATTCAGAACATCTTGGATACTCGTCTGAAAGGGGTTGTTAGAGGCGGAAGGGGAGGATGTTGGGTTGTAACTGCCCTAACCCCTGTGCTTCTCTCAGGCCTGGGATCCTGCCCAAGCAAAAGTGGTCCTTAGGAGAGCGGCTCCTGGGTTACAGAGTAGGCGCAATCTCTGACTGGTGGTGGAGTGGAGGGGAGGGTTAAATAGTACAACAGGGCAGTGGGTAGGACAGCCCGGAGTCTCCTAGACCCTCCCTCCAAATCCAGGGGGATTTTGCTGTGTGCTGTGTAGCCCTGACCTCCCTCCTCCAGACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGGTGGGAAGAGAAAATGAAGCGTGGGAGTCAAGAATGGGGTTGATTTGGAGATTCAGTGTGTGACCTCCATCCTCAAATTTTCTATTGCCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGTGCTGAGAAGGAAGGGGTGGCAGGGATGTGGACCCGAGACGGTGGGAGCAGGAATGGGAGGGGACTAGGCTACTAGGGCCCCACTAGAGAAAGGAGAGGGAAAGGGCTTCTCACTTTCCCTTCCCAGGTCACAGAGTGGCCGAGAGGCAGGGAAAATAGAAGGCAGGCCCAAGGCCTCCAGCTCCACGTCCACCTCTAACATGGTCCCCTCCACAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGTAAGTGGGAGAGGGGGGCTGCCCTCTGCTCTCTTGCAGGGGCAGTTGTGGCAACAGGCATCTCACCTGATAATCTCCAGTCTGCTCCATCCAGGCTGAACAAGGGCCAATGACCTCTTTAGGCCCAGAATGGGATGGCAAAGGGAGGGTTACTGGTGATTCTCTGCCTGCACATCTTTGTGCTGATGAGGGACAGCACTGGGCACATGGTCCTCTGAGGGGAAGTTACAGTAGTAGAGGCGGAGTGCGCCTGTAACTGGCCTCTGGCCTGTGCATTCTTTCACAGGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGGTAAAGCATAGGCACAGCACATTCCCCCTACACATTAAAACTCAAGGTGGAGGGGTCAACGGGGCGGACTGGACCCAGGGTGTGCTCCTCATTTCCACACAGTGGTGGAGGGAAGGGATAGGAACAGAACATGGAGGGAGGCTCAGCAGGCTCCCAGGACACATGCACTTGAGGCCCAAAAGGACCTCTGCTCCCCCAGTCACTTGATGCGGGAAAACATGCACCTTCTTAGGGAAGATCTAGGAGAAAGGAAACAGTAAGCCACTGCTTCTTGGAAAATCTTCTGGGGGTCTGACCTGCTGGGACTGTTCCCTTTCCTCTTGCCCCGTAAGATTCCTAGGGCGGGGGGGGGGGGGGTCACTCTTTTCTGATCTACATTCTGATCTTGGGACTTCTTTCAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTCCCCTTGTGTTTTGTTGTCTCACATTTAGATATCAGCCATGCATGACTGAATGGCTTCCAATCATATACTCACCTATCACCTACAAGAGAACAATGAAAAACACACACAAAAACAAAATCTTGAATTTTGTAATCATGCCTATTGCTATTTCTTGAGCATAAGAATGGCTCAGATACTTTCCAAGACATAAAAGGAAGGCAGAGGAATAGTTGTTGCTGTAAAAGACATCAAGAATAAATGGGTCATGTACAACGGGAGGGGCCGGTTACCTGAATAATGGAGTGGAGATTGAGCTATCCTAGCTCCTCTGCTCACTAACTGACCTGTCGCATGACCGTGGACAAAACCCTGAACGCAGCTGTTTGTTTGCTAAAC
GCAAAGGCTGAGACAGAACCAGCTTGAGAGCGGAGGCGCAACTCTTGTCTCCTGGTGGCCTTGAGCATTTCACAATAGGGGGATAAAGGATAGGAGCAGAAAAGTGGGGCTGACTTCAGAAATGGGGTCCTCTAGAGCTCACGGGAGGGTGTTAGATTGGAGTGGGAGCTTAGTGGAGGTGAGCCTTAGAGGCAAAAGTCTCCAGACCAATCCAGGGCCCCTCTTCTATCCGGGGGCCCCTCTTCTATCCAGGGCCCCTCTTCTGTCTGGGAGCCCCTCTTCTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGTTTTCCTTTGTGCCTCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGTGAGTACCTCCAAGCCCAGGACGCCCACAGGTGCTTCCTTCTCTCCTGGATTAACTGCTCAGATTACCAATTATTTCATTATTGTTTGGTAGAGGTCACTTTGGACTTTGGTGGAGCCAGGGGATGTGTGCGTAGCACACAAATCCACAAGCCCTTGAGTTTTGGACTGCCACGTCTGCTGGGGGGCTCAGAGGCCTTTTTGCTCTGAGCTGCCCACGGTGGTCCTGATAGCTGAGGTGCAGTATCTGGCCCCCTGTCTTCCTCAGAAAAGCCCCAGCTTCCCATGACATAATAGCACCGACAGGGATTTTACAAACACAGCCAGGTGGAATTTGTTTTGCAAAGTGTCCGCGCCAGGAGCTGCTGTACTCCTGAACCATGACCCTCCTCTCCCTTCCTCCTCAGGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACGTGAGTTGCTCAAACCAAATGGGGGTGGGGTGGGTGGGGAGTCCCGTTGTCTCAAAGCAGCTCCTCACTCTTCTCCATCCCCCCAGACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATGTATCCTTCCTGCCGCCCCTTCCCGACCCTCTGTCATCAGCCCACGGGGGCCAAGGCAACATACAGGGTGCCCAGTCAGGCAAAGGGCCCTAATTTGTGCCCAGGGAAACTTAAGGAGACCCTGATTCAGAACATCTTGGATACTCGTCTGAAAGGGGTTGTTAGAGGCGGAAGGGGAGGATGTTGGGTTGTAACTGCCCTAACCCCTGTGCTTCTCTCAGGCCTGGGATCCTGCCCAAGCAAAAGTGGTCCTTAGGAGAGCGGCTCCTGGGTTACAGAGTAGGCGCAATCTCTGACTGGTGGTGGAGTGGAGGGGAGGGTTAAATAGTACAACAGGGCAGTGGGTAGGACAGCCCGGAGTCTCCTAGACCCTCCCTCCAAATCCAGGGGGATTTTGCTGTGTGCTGTGTAGCCCTGACCTCCCTCCTCCAGACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGGTGGGAAGAGAAAATGAAGCGTGGGAGTCAAGAATGGGGTTGATTTGGAGATTCAGTGTGTGACCTCCATCCTCAAATTTTCTATTGCCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGGGAAATGCAGTCAACGACGCAGGTGCTGAGAAGGAAGGGGTGGCAGGGATGTGGACCCGAGACGGTGGGAGCAGGAATGGGAGGGGACTAGGCTACTAGGGCCCCACTAGAGAAAGGAGAGGGAAAGGGCTTCTCACTTTCCCTTCCCAGGTCACAGAGTGGCCGAGAGGCAGGGAAAATAGAAGGCAGGCCCAAGGCCTCCAGCTCCACGTCCACCTCTAACATGGTCCCCTCCACAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGTAAGTGGGAGAGGGGGGCTGCCCTCTGCTCTCTTGCAGGGGCAGTTGTGGCAACAGGCATCTCACCTGATAATCTCCAGTCTGCTCCATCCAGGCTGAACAAGGGCCAATGACCTCTTTAGGCCCAGAATGGGATGGCAAAGGGAGGGTTACTGGTGATTCTCTGCCTGCACATCTTTGTGCTGATGAGGGACAGCACTGGGCACATGGTCCTCTGAGGGGAAGTTACAGTAGTAGAGGCGGAGTGCGCCTGTAACTGGCCTCTGGCCTGTGCATTCTTTCACAGGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGGTAAAGCATAGGCACAGCACATTCCCCCTACACATTAAAACTCAAGGTGGAGGGGTCAACGGGGCGGACTGGACCCAGGGTGTGCTCCTCATTTCCACACAGTGGTGGAGGGAAGGGATAGGAACAGAACATGGAGGGAGGCTCAGCAGGCTCCCAGGACACATGCACTTGAGGCCCAAAAGGACCTCTGCTCCCCCAGTCACTTGATGCGGGAAAACATGCACCTTCTTAGGGAAGATCTAGGAGAAAGGAAACAGTAAGCCACTGCTTCTTGGAAAATCTTCTGGGGGTCTGACCTGCTGGGACTGTTCCCTTTCCTCTTGCCCCGTAAGATTCCTAGGGCGGGGGGGGGGGGGGTCACTCTTTTCTGATCTACATTCTGATCTTGGGACTTCTTTCAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTCCCCTTGTGTTTTGTTGTCTCACATTTAGATATCAGCCATGCATGACTGAATGGCTTCCAATCATATACTCACCTATCACCTACAAGAGAACAATGAAAAACACACACAAAAACAAAATCTTGAATTTTGTAATCATGCCTATTGCTATTTCTTGAGCATAAGAATGGCTCAGATACTTTCCAAGACATAAAAGGAAGGCAGAGGAATAGTTGTTGCTGTAAAAGACATCAAGAATAAATGGGTCATGTACAACGGGAGGGGCCGGTTACCTGAATAATGGAGTGGAGATTGAGCTATCCTAGCTCCTCTGCTCACTAACTGACCTGTCGCATGACCGTGGACAAAACCCTGAACGCAGCTGTTTGTTTGCTAAAC
Task1_train_20597
This sequence change occurs on Chromosome 15, altering CAPN3 (calpain 3). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Autosomal recessive limb-girdle muscular dystrophy type 2A
CTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGTTTTCCTTTGTGCCTCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGTGAGTACCTCCAAGCCCAGGACGCCCACAGGTGCTTCCTTCTCTCCTGGATTAACTGCTCAGATTACCAATTATTTCATTATTGTTTGGTAGAGGTCACTTTGGACTTTGGTGGAGCCAGGGGATGTGTGCGTAGCACACAAATCCACAAGCCCTTGAGTTTTGGACTGCCACGTCTGCTGGGGGGCTCAGAGGCCTTTTTGCTCTGAGCTGCCCACGGTGGTCCTGATAGCTGAGGTGCAGTATCTGGCCCCCTGTCTTCCTCAGAAAAGCCCCAGCTTCCCATGACATAATAGCACCGACAGGGATTTTACAAACACAGCCAGGTGGAATTTGTTTTGCAAAGTGTCCGCGCCAGGAGCTGCTGTACTCCTGAACCATGACCCTCCTCTCCCTTCCTCCTCAGGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACGTGAGTTGCTCAAACCAAATGGGGGTGGGGTGGGTGGGGAGTCCCGTTGTCTCAAAGCAGCTCCTCACTCTTCTCCATCCCCCCAGACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATGTATCCTTCCTGCCGCCCCTTCCCGACCCTCTGTCATCAGCCCACGGGGGCCAAGGCAACATACAGGGTGCCCAGTCAGGCAAAGGGCCCTAATTTGTGCCCAGGGAAACTTAAGGAGACCCTGATTCAGAACATCTTGGATACTCGTCTGAAAGGGGTTGTTAGAGGCGGAAGGGGAGGATGTTGGGTTGTAACTGCCCTAACCCCTGTGCTTCTCTCAGGCCTGGGATCCTGCCCAAGCAAAAGTGGTCCTTAGGAGAGCGGCTCCTGGGTTACAGAGTAGGCGCAATCTCTGACTGGTGGTGGAGTGGAGGGGAGGGTTAAATAGTACAACAGGGCAGTGGGTAGGACAGCCCGGAGTCTCCTAGACCCTCCCTCCAAATCCAGGGGGATTTTGCTGTGTGCTGTGTAGCCCTGACCTCCCTCCTCCAGACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGGTGGGAAGAGAAAATGAAGCGTGGGAGTCAAGAATGGGGTTGATTTGGAGATTCAGTGTGTGACCTCCATCCTCAAATTTTCTATTGCCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGTGCTGAGAAGGAAGGGGTGGCAGGGATGTGGACCCGAGACGGTGGGAGCAGGAATGGGAGGGGACTAGGCTACTAGGGCCCCACTAGAGAAAGGAGAGGGAAAGGGCTTCTCACTTTCCCTTCCCAGGTCACAGAGTGGCCGAGAGGCAGGGAAAATAGAAGGCAGGCCCAAGGCCTCCAGCTCCACGTCCACCTCTAACATGGTCCCCTCCACAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGTAAGTGGGAGAGGGGGGCTGCCCTCTGCTCTCTTGCAGGGGCAGTTGTGGCAACAGGCATCTCACCTGATAATCTCCAGTCTGCTCCATCCAGGCTGAACAAGGGCCAATGACCTCTTTAGGCCCAGAATGGGATGGCAAAGGGAGGGTTACTGGTGATTCTCTGCCTGCACATCTTTGTGCTGATGAGGGACAGCACTGGGCACATGGTCCTCTGAGGGGAAGTTACAGTAGTAGAGGCGGAGTGCGCCTGTAACTGGCCTCTGGCCTGTGCATTCTTTCACAGGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGGTAAAGCATAGGCACAGCACATTCCCCCTACACATTAAAACTCAAGGTGGAGGGGTCAACGGGGCGGACTGGACCCAGGGTGTGCTCCTCATTTCCACACAGTGGTGGAGGGAAGGGATAGGAACAGAACATGGAGGGAGGCTCAGCAGGCTCCCAGGACACATGCACTTGAGGCCCAAAAGGACCTCTGCTCCCCCAGTCACTTGATGCGGGAAAACATGCACCTTCTTAGGGAAGATCTAGGAGAAAGGAAACAGTAAGCCACTGCTTCTTGGAAAATCTTCTGGGGGTCTGACCTGCTGGGACTGTTCCCTTTCCTCTTGCCCCGTAAGATTCCTAGGGCGGGGGGGGGGGGGGTCACTCTTTTCTGATCTACATTCTGATCTTGGGACTTCTTTCAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTCCCCTTGTGTTTTGTTGTCTCACATTTAGATATCAGCCATGCATGACTGAATGGCTTCCAATCATATACTCACCTATCACCTACAAGAGAACAATGAAAAACACACACAAAAACAAAATCTTGAATTTTGTAATCATGCCTATTGCTATTTCTTGAGCATAAGAATGGCTCAGATACTTTCCAAGACATAAAAGGAAGGCAGAGGAATAGTTGTTGCTGTAAAAGACATCAAGAATAAATGGGTCATGTACAACGGGAGGGGCCGGTTACCTGAATAATGGAGTGGAGATTGAGCTATCCTAGCTCCTCTGCTCACTAACTGACCTGTCGCATGACCGTGGACAAAACCCTGAACGCAGCTGTTTGTTTGCTAAACTTCTCTGGACCATGGCCTGCGGCATATCTATAGGCATCCTGTGTTTTCCACCCAGTTTCCTTCTTCCTCGCTAAGCCAACGTGGAAAGGGCTGGCCGTGAATATGCAGACAAGGTAACGAAAGTAAACCGTCAATTAGTAAAAGTACTTTATTTTCCTCTTGTATTTGCTTTATATCTTGCTTTACAAAGTTACGAAGTTCACAGCTTTATACCAAAATGTAAGAAGGCTATTTGCTTATAAACATTTTTGCAGTCAGGTGTCATCTGATTTCATTCTTCT
CTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGTTTTCCTTTGTGCCTCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGTGAGTACCTCCAAGCCCAGGACGCCCACAGGTGCTTCCTTCTCTCCTGGATTAACTGCTCAGATTACCAATTATTTCATTATTGTTTGGTAGAGGTCACTTTGGACTTTGGTGGAGCCAGGGGATGTGTGCGTAGCACACAAATCCACAAGCCCTTGAGTTTTGGACTGCCACGTCTGCTGGGGGGCTCAGAGGCCTTTTTGCTCTGAGCTGCCCACGGTGGTCCTGATAGCTGAGGTGCAGTATCTGGCCCCCTGTCTTCCTCAGAAAAGCCCCAGCTTCCCATGACATAATAGCACCGACAGGGATTTTACAAACACAGCCAGGTGGAATTTGTTTTGCAAAGTGTCCGCGCCAGGAGCTGCTGTACTCCTGAACCATGACCCTCCTCTCCCTTCCTCCTCAGGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACGTGAGTTGCTCAAACCAAATGGGGGTGGGGTGGGTGGGGAGTCCCGTTGTCTCAAAGCAGCTCCTCACTCTTCTCCATCCCCCCAGACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATGTATCCTTCCTGCCGCCCCTTCCCGACCCTCTGTCATCAGCCCACGGGGGCCAAGGCAACATACAGGGTGCCCAGTCAGGCAAAGGGCCCTAATTTGTGCCCAGGGAAACTTAAGGAGACCCTGATTCAGAACATCTTGGATACTCGTCTGAAAGGGGTTGTTAGAGGCGGAAGGGGAGGATGTTGGGTTGTAACTGCCCTAACCCCTGTGCTTCTCTCAGGCCTGGGATCCTGCCCAAGCAAAAGTGGTCCTTAGGAGAGCGGCTCCTGGGTTACAGAGTAGGCGCAATCTCTGACTGGTGGTGGAGTGGAGGGGAGGGTTAAATAGTACAACAGGGCAGTGGGTAGGACAGCCCGGAGTCTCCTAGACCCTCCCTCCAAATCCAGGGGGATTTTGCTGTGTGCTGTGTAGCCCTGACCTCCCTCCTCCAGACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGGTGGGAAGAGAAAATGAAGCGTGGGAGTCAAGAATGGGGTTGATTTGGAGATTCAGTGTGTGACCTCCATCCTCAAATTTTCTATTGCCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGTGCTGAGAAGGAAGGGGTGGCAGGGATGTGGACCCGAGACGGTGGGAGCAGGAATGGGAGGGGACTAGGCTACTAGGGCCCCACTAGAGAAAGGAGAGGGAAAGGGCTTCTCACTTTCCCTTCCCAGGTCACAGAGTGGCCGAGAGGCAGGGAAAATAGAAGGCAGGCCCAAGGCCTCCAGCTCCACGTCCACCTCTAACATGGTCCCCTCCACAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCAGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGTAAGTGGGAGAGGGGGGCTGCCCTCTGCTCTCTTGCAGGGGCAGTTGTGGCAACAGGCATCTCACCTGATAATCTCCAGTCTGCTCCATCCAGGCTGAACAAGGGCCAATGACCTCTTTAGGCCCAGAATGGGATGGCAAAGGGAGGGTTACTGGTGATTCTCTGCCTGCACATCTTTGTGCTGATGAGGGACAGCACTGGGCACATGGTCCTCTGAGGGGAAGTTACAGTAGTAGAGGCGGAGTGCGCCTGTAACTGGCCTCTGGCCTGTGCATTCTTTCACAGGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGGTAAAGCATAGGCACAGCACATTCCCCCTACACATTAAAACTCAAGGTGGAGGGGTCAACGGGGCGGACTGGACCCAGGGTGTGCTCCTCATTTCCACACAGTGGTGGAGGGAAGGGATAGGAACAGAACATGGAGGGAGGCTCAGCAGGCTCCCAGGACACATGCACTTGAGGCCCAAAAGGACCTCTGCTCCCCCAGTCACTTGATGCGGGAAAACATGCACCTTCTTAGGGAAGATCTAGGAGAAAGGAAACAGTAAGCCACTGCTTCTTGGAAAATCTTCTGGGGGTCTGACCTGCTGGGACTGTTCCCTTTCCTCTTGCCCCGTAAGATTCCTAGGGCGGGGGGGGGGGGGGTCACTCTTTTCTGATCTACATTCTGATCTTGGGACTTCTTTCAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTCCCCTTGTGTTTTGTTGTCTCACATTTAGATATCAGCCATGCATGACTGAATGGCTTCCAATCATATACTCACCTATCACCTACAAGAGAACAATGAAAAACACACACAAAAACAAAATCTTGAATTTTGTAATCATGCCTATTGCTATTTCTTGAGCATAAGAATGGCTCAGATACTTTCCAAGACATAAAAGGAAGGCAGAGGAATAGTTGTTGCTGTAAAAGACATCAAGAATAAATGGGTCATGTACAACGGGAGGGGCCGGTTACCTGAATAATGGAGTGGAGATTGAGCTATCCTAGCTCCTCTGCTCACTAACTGACCTGTCGCATGACCGTGGACAAAACCCTGAACGCAGCTGTTTGTTTGCTAAACTTCTCTGGACCATGGCCTGCGGCATATCTATAGGCATCCTGTGTTTTCCACCCAGTTTCCTTCTTCCTCGCTAAGCCAACGTGGAAAGGGCTGGCCGTGAATATGCAGACAAGGTAACGAAAGTAAACCGTCAATTAGTAAAAGTACTTTATTTTCCTCTTGTATTTGCTTTATATCTTGCTTTACAAAGTTACGAAGTTCACAGCTTTATACCAAAATGTAAGAAGGCTATTTGCTTATAAACATTTTTGCAGTCAGGTGTCATCTGATTTCATTCTTCT
Task1_train_20598
Located on Chromosome 15, this mutation impacts CAPN3 (calpain 3). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Abnormality of the musculature
CTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGTTTTCCTTTGTGCCTCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGTGAGTACCTCCAAGCCCAGGACGCCCACAGGTGCTTCCTTCTCTCCTGGATTAACTGCTCAGATTACCAATTATTTCATTATTGTTTGGTAGAGGTCACTTTGGACTTTGGTGGAGCCAGGGGATGTGTGCGTAGCACACAAATCCACAAGCCCTTGAGTTTTGGACTGCCACGTCTGCTGGGGGGCTCAGAGGCCTTTTTGCTCTGAGCTGCCCACGGTGGTCCTGATAGCTGAGGTGCAGTATCTGGCCCCCTGTCTTCCTCAGAAAAGCCCCAGCTTCCCATGACATAATAGCACCGACAGGGATTTTACAAACACAGCCAGGTGGAATTTGTTTTGCAAAGTGTCCGCGCCAGGAGCTGCTGTACTCCTGAACCATGACCCTCCTCTCCCTTCCTCCTCAGGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACGTGAGTTGCTCAAACCAAATGGGGGTGGGGTGGGTGGGGAGTCCCGTTGTCTCAAAGCAGCTCCTCACTCTTCTCCATCCCCCCAGACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATGTATCCTTCCTGCCGCCCCTTCCCGACCCTCTGTCATCAGCCCACGGGGGCCAAGGCAACATACAGGGTGCCCAGTCAGGCAAAGGGCCCTAATTTGTGCCCAGGGAAACTTAAGGAGACCCTGATTCAGAACATCTTGGATACTCGTCTGAAAGGGGTTGTTAGAGGCGGAAGGGGAGGATGTTGGGTTGTAACTGCCCTAACCCCTGTGCTTCTCTCAGGCCTGGGATCCTGCCCAAGCAAAAGTGGTCCTTAGGAGAGCGGCTCCTGGGTTACAGAGTAGGCGCAATCTCTGACTGGTGGTGGAGTGGAGGGGAGGGTTAAATAGTACAACAGGGCAGTGGGTAGGACAGCCCGGAGTCTCCTAGACCCTCCCTCCAAATCCAGGGGGATTTTGCTGTGTGCTGTGTAGCCCTGACCTCCCTCCTCCAGACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGGTGGGAAGAGAAAATGAAGCGTGGGAGTCAAGAATGGGGTTGATTTGGAGATTCAGTGTGTGACCTCCATCCTCAAATTTTCTATTGCCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGTGCTGAGAAGGAAGGGGTGGCAGGGATGTGGACCCGAGACGGTGGGAGCAGGAATGGGAGGGGACTAGGCTACTAGGGCCCCACTAGAGAAAGGAGAGGGAAAGGGCTTCTCACTTTCCCTTCCCAGGTCACAGAGTGGCCGAGAGGCAGGGAAAATAGAAGGCAGGCCCAAGGCCTCCAGCTCCACGTCCACCTCTAACATGGTCCCCTCCACAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGTAAGTGGGAGAGGGGGGCTGCCCTCTGCTCTCTTGCAGGGGCAGTTGTGGCAACAGGCATCTCACCTGATAATCTCCAGTCTGCTCCATCCAGGCTGAACAAGGGCCAATGACCTCTTTAGGCCCAGAATGGGATGGCAAAGGGAGGGTTACTGGTGATTCTCTGCCTGCACATCTTTGTGCTGATGAGGGACAGCACTGGGCACATGGTCCTCTGAGGGGAAGTTACAGTAGTAGAGGCGGAGTGCGCCTGTAACTGGCCTCTGGCCTGTGCATTCTTTCACAGGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGGTAAAGCATAGGCACAGCACATTCCCCCTACACATTAAAACTCAAGGTGGAGGGGTCAACGGGGCGGACTGGACCCAGGGTGTGCTCCTCATTTCCACACAGTGGTGGAGGGAAGGGATAGGAACAGAACATGGAGGGAGGCTCAGCAGGCTCCCAGGACACATGCACTTGAGGCCCAAAAGGACCTCTGCTCCCCCAGTCACTTGATGCGGGAAAACATGCACCTTCTTAGGGAAGATCTAGGAGAAAGGAAACAGTAAGCCACTGCTTCTTGGAAAATCTTCTGGGGGTCTGACCTGCTGGGACTGTTCCCTTTCCTCTTGCCCCGTAAGATTCCTAGGGCGGGGGGGGGGGGGGTCACTCTTTTCTGATCTACATTCTGATCTTGGGACTTCTTTCAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTCCCCTTGTGTTTTGTTGTCTCACATTTAGATATCAGCCATGCATGACTGAATGGCTTCCAATCATATACTCACCTATCACCTACAAGAGAACAATGAAAAACACACACAAAAACAAAATCTTGAATTTTGTAATCATGCCTATTGCTATTTCTTGAGCATAAGAATGGCTCAGATACTTTCCAAGACATAAAAGGAAGGCAGAGGAATAGTTGTTGCTGTAAAAGACATCAAGAATAAATGGGTCATGTACAACGGGAGGGGCCGGTTACCTGAATAATGGAGTGGAGATTGAGCTATCCTAGCTCCTCTGCTCACTAACTGACCTGTCGCATGACCGTGGACAAAACCCTGAACGCAGCTGTTTGTTTGCTAAACTTCTCTGGACCATGGCCTGCGGCATATCTATAGGCATCCTGTGTTTTCCACCCAGTTTCCTTCTTCCTCGCTAAGCCAACGTGGAAAGGGCTGGCCGTGAATATGCAGACAAGGTAACGAAAGTAAACCGTCAATTAGTAAAAGTACTTTATTTTCCTCTTGTATTTGCTTTATATCTTGCTTTACAAAGTTACGAAGTTCACAGCTTTATACCAAAATGTAAGAAGGCTATTTGCTTATAAACATTTTTGCAGTCAGGTGTCATCTGATTTCATTCTTCT
CTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGTTTTCCTTTGTGCCTCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGTGAGTACCTCCAAGCCCAGGACGCCCACAGGTGCTTCCTTCTCTCCTGGATTAACTGCTCAGATTACCAATTATTTCATTATTGTTTGGTAGAGGTCACTTTGGACTTTGGTGGAGCCAGGGGATGTGTGCGTAGCACACAAATCCACAAGCCCTTGAGTTTTGGACTGCCACGTCTGCTGGGGGGCTCAGAGGCCTTTTTGCTCTGAGCTGCCCACGGTGGTCCTGATAGCTGAGGTGCAGTATCTGGCCCCCTGTCTTCCTCAGAAAAGCCCCAGCTTCCCATGACATAATAGCACCGACAGGGATTTTACAAACACAGCCAGGTGGAATTTGTTTTGCAAAGTGTCCGCGCCAGGAGCTGCTGTACTCCTGAACCATGACCCTCCTCTCCCTTCCTCCTCAGGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACGTGAGTTGCTCAAACCAAATGGGGGTGGGGTGGGTGGGGAGTCCCGTTGTCTCAAAGCAGCTCCTCACTCTTCTCCATCCCCCCAGACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATGTATCCTTCCTGCCGCCCCTTCCCGACCCTCTGTCATCAGCCCACGGGGGCCAAGGCAACATACAGGGTGCCCAGTCAGGCAAAGGGCCCTAATTTGTGCCCAGGGAAACTTAAGGAGACCCTGATTCAGAACATCTTGGATACTCGTCTGAAAGGGGTTGTTAGAGGCGGAAGGGGAGGATGTTGGGTTGTAACTGCCCTAACCCCTGTGCTTCTCTCAGGCCTGGGATCCTGCCCAAGCAAAAGTGGTCCTTAGGAGAGCGGCTCCTGGGTTACAGAGTAGGCGCAATCTCTGACTGGTGGTGGAGTGGAGGGGAGGGTTAAATAGTACAACAGGGCAGTGGGTAGGACAGCCCGGAGTCTCCTAGACCCTCCCTCCAAATCCAGGGGGATTTTGCTGTGTGCTGTGTAGCCCTGACCTCCCTCCTCCAGACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGGTGGGAAGAGAAAATGAAGCGTGGGAGTCAAGAATGGGGTTGATTTGGAGATTCAGTGTGTGACCTCCATCCTCAAATTTTCTATTGCCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGTGCTGAGAAGGAAGGGGTGGCAGGGATGTGGACCCGAGACGGTGGGAGCAGGAATGGGAGGGGACTAGGCTACTAGGGCCCCACTAGAGAAAGGAGAGGGAAAGGGCTTCTCACTTTCCCTTCCCAGGTCACAGAGTGGCCGAGAGGCAGGGAAAATAGAAGGCAGGCCCAAGGCCTCCAGCTCCACGTCCACCTCTAACATGGTCCCCTCCACAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCAGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGTAAGTGGGAGAGGGGGGCTGCCCTCTGCTCTCTTGCAGGGGCAGTTGTGGCAACAGGCATCTCACCTGATAATCTCCAGTCTGCTCCATCCAGGCTGAACAAGGGCCAATGACCTCTTTAGGCCCAGAATGGGATGGCAAAGGGAGGGTTACTGGTGATTCTCTGCCTGCACATCTTTGTGCTGATGAGGGACAGCACTGGGCACATGGTCCTCTGAGGGGAAGTTACAGTAGTAGAGGCGGAGTGCGCCTGTAACTGGCCTCTGGCCTGTGCATTCTTTCACAGGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGGTAAAGCATAGGCACAGCACATTCCCCCTACACATTAAAACTCAAGGTGGAGGGGTCAACGGGGCGGACTGGACCCAGGGTGTGCTCCTCATTTCCACACAGTGGTGGAGGGAAGGGATAGGAACAGAACATGGAGGGAGGCTCAGCAGGCTCCCAGGACACATGCACTTGAGGCCCAAAAGGACCTCTGCTCCCCCAGTCACTTGATGCGGGAAAACATGCACCTTCTTAGGGAAGATCTAGGAGAAAGGAAACAGTAAGCCACTGCTTCTTGGAAAATCTTCTGGGGGTCTGACCTGCTGGGACTGTTCCCTTTCCTCTTGCCCCGTAAGATTCCTAGGGCGGGGGGGGGGGGGGTCACTCTTTTCTGATCTACATTCTGATCTTGGGACTTCTTTCAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTCCCCTTGTGTTTTGTTGTCTCACATTTAGATATCAGCCATGCATGACTGAATGGCTTCCAATCATATACTCACCTATCACCTACAAGAGAACAATGAAAAACACACACAAAAACAAAATCTTGAATTTTGTAATCATGCCTATTGCTATTTCTTGAGCATAAGAATGGCTCAGATACTTTCCAAGACATAAAAGGAAGGCAGAGGAATAGTTGTTGCTGTAAAAGACATCAAGAATAAATGGGTCATGTACAACGGGAGGGGCCGGTTACCTGAATAATGGAGTGGAGATTGAGCTATCCTAGCTCCTCTGCTCACTAACTGACCTGTCGCATGACCGTGGACAAAACCCTGAACGCAGCTGTTTGTTTGCTAAACTTCTCTGGACCATGGCCTGCGGCATATCTATAGGCATCCTGTGTTTTCCACCCAGTTTCCTTCTTCCTCGCTAAGCCAACGTGGAAAGGGCTGGCCGTGAATATGCAGACAAGGTAACGAAAGTAAACCGTCAATTAGTAAAAGTACTTTATTTTCCTCTTGTATTTGCTTTATATCTTGCTTTACAAAGTTACGAAGTTCACAGCTTTATACCAAAATGTAAGAAGGCTATTTGCTTATAAACATTTTTGCAGTCAGGTGTCATCTGATTTCATTCTTCT
Task1_train_20599
This sequence change occurs on Chromosome 15, altering CAPN3 (calpain 3). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Muscular dystrophy, limb-girdle, autosomal dominant 4
CTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGTTTTCCTTTGTGCCTCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGTGAGTACCTCCAAGCCCAGGACGCCCACAGGTGCTTCCTTCTCTCCTGGATTAACTGCTCAGATTACCAATTATTTCATTATTGTTTGGTAGAGGTCACTTTGGACTTTGGTGGAGCCAGGGGATGTGTGCGTAGCACACAAATCCACAAGCCCTTGAGTTTTGGACTGCCACGTCTGCTGGGGGGCTCAGAGGCCTTTTTGCTCTGAGCTGCCCACGGTGGTCCTGATAGCTGAGGTGCAGTATCTGGCCCCCTGTCTTCCTCAGAAAAGCCCCAGCTTCCCATGACATAATAGCACCGACAGGGATTTTACAAACACAGCCAGGTGGAATTTGTTTTGCAAAGTGTCCGCGCCAGGAGCTGCTGTACTCCTGAACCATGACCCTCCTCTCCCTTCCTCCTCAGGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACGTGAGTTGCTCAAACCAAATGGGGGTGGGGTGGGTGGGGAGTCCCGTTGTCTCAAAGCAGCTCCTCACTCTTCTCCATCCCCCCAGACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATGTATCCTTCCTGCCGCCCCTTCCCGACCCTCTGTCATCAGCCCACGGGGGCCAAGGCAACATACAGGGTGCCCAGTCAGGCAAAGGGCCCTAATTTGTGCCCAGGGAAACTTAAGGAGACCCTGATTCAGAACATCTTGGATACTCGTCTGAAAGGGGTTGTTAGAGGCGGAAGGGGAGGATGTTGGGTTGTAACTGCCCTAACCCCTGTGCTTCTCTCAGGCCTGGGATCCTGCCCAAGCAAAAGTGGTCCTTAGGAGAGCGGCTCCTGGGTTACAGAGTAGGCGCAATCTCTGACTGGTGGTGGAGTGGAGGGGAGGGTTAAATAGTACAACAGGGCAGTGGGTAGGACAGCCCGGAGTCTCCTAGACCCTCCCTCCAAATCCAGGGGGATTTTGCTGTGTGCTGTGTAGCCCTGACCTCCCTCCTCCAGACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGGTGGGAAGAGAAAATGAAGCGTGGGAGTCAAGAATGGGGTTGATTTGGAGATTCAGTGTGTGACCTCCATCCTCAAATTTTCTATTGCCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGTGCTGAGAAGGAAGGGGTGGCAGGGATGTGGACCCGAGACGGTGGGAGCAGGAATGGGAGGGGACTAGGCTACTAGGGCCCCACTAGAGAAAGGAGAGGGAAAGGGCTTCTCACTTTCCCTTCCCAGGTCACAGAGTGGCCGAGAGGCAGGGAAAATAGAAGGCAGGCCCAAGGCCTCCAGCTCCACGTCCACCTCTAACATGGTCCCCTCCACAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGTAAGTGGGAGAGGGGGGCTGCCCTCTGCTCTCTTGCAGGGGCAGTTGTGGCAACAGGCATCTCACCTGATAATCTCCAGTCTGCTCCATCCAGGCTGAACAAGGGCCAATGACCTCTTTAGGCCCAGAATGGGATGGCAAAGGGAGGGTTACTGGTGATTCTCTGCCTGCACATCTTTGTGCTGATGAGGGACAGCACTGGGCACATGGTCCTCTGAGGGGAAGTTACAGTAGTAGAGGCGGAGTGCGCCTGTAACTGGCCTCTGGCCTGTGCATTCTTTCACAGGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGGTAAAGCATAGGCACAGCACATTCCCCCTACACATTAAAACTCAAGGTGGAGGGGTCAACGGGGCGGACTGGACCCAGGGTGTGCTCCTCATTTCCACACAGTGGTGGAGGGAAGGGATAGGAACAGAACATGGAGGGAGGCTCAGCAGGCTCCCAGGACACATGCACTTGAGGCCCAAAAGGACCTCTGCTCCCCCAGTCACTTGATGCGGGAAAACATGCACCTTCTTAGGGAAGATCTAGGAGAAAGGAAACAGTAAGCCACTGCTTCTTGGAAAATCTTCTGGGGGTCTGACCTGCTGGGACTGTTCCCTTTCCTCTTGCCCCGTAAGATTCCTAGGGCGGGGGGGGGGGGGGTCACTCTTTTCTGATCTACATTCTGATCTTGGGACTTCTTTCAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTCCCCTTGTGTTTTGTTGTCTCACATTTAGATATCAGCCATGCATGACTGAATGGCTTCCAATCATATACTCACCTATCACCTACAAGAGAACAATGAAAAACACACACAAAAACAAAATCTTGAATTTTGTAATCATGCCTATTGCTATTTCTTGAGCATAAGAATGGCTCAGATACTTTCCAAGACATAAAAGGAAGGCAGAGGAATAGTTGTTGCTGTAAAAGACATCAAGAATAAATGGGTCATGTACAACGGGAGGGGCCGGTTACCTGAATAATGGAGTGGAGATTGAGCTATCCTAGCTCCTCTGCTCACTAACTGACCTGTCGCATGACCGTGGACAAAACCCTGAACGCAGCTGTTTGTTTGCTAAACTTCTCTGGACCATGGCCTGCGGCATATCTATAGGCATCCTGTGTTTTCCACCCAGTTTCCTTCTTCCTCGCTAAGCCAACGTGGAAAGGGCTGGCCGTGAATATGCAGACAAGGTAACGAAAGTAAACCGTCAATTAGTAAAAGTACTTTATTTTCCTCTTGTATTTGCTTTATATCTTGCTTTACAAAGTTACGAAGTTCACAGCTTTATACCAAAATGTAAGAAGGCTATTTGCTTATAAACATTTTTGCAGTCAGGTGTCATCTGATTTCATTCTTCT
CTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGTTTTCCTTTGTGCCTCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGTGAGTACCTCCAAGCCCAGGACGCCCACAGGTGCTTCCTTCTCTCCTGGATTAACTGCTCAGATTACCAATTATTTCATTATTGTTTGGTAGAGGTCACTTTGGACTTTGGTGGAGCCAGGGGATGTGTGCGTAGCACACAAATCCACAAGCCCTTGAGTTTTGGACTGCCACGTCTGCTGGGGGGCTCAGAGGCCTTTTTGCTCTGAGCTGCCCACGGTGGTCCTGATAGCTGAGGTGCAGTATCTGGCCCCCTGTCTTCCTCAGAAAAGCCCCAGCTTCCCATGACATAATAGCACCGACAGGGATTTTACAAACACAGCCAGGTGGAATTTGTTTTGCAAAGTGTCCGCGCCAGGAGCTGCTGTACTCCTGAACCATGACCCTCCTCTCCCTTCCTCCTCAGGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACGTGAGTTGCTCAAACCAAATGGGGGTGGGGTGGGTGGGGAGTCCCGTTGTCTCAAAGCAGCTCCTCACTCTTCTCCATCCCCCCAGACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATGTATCCTTCCTGCCGCCCCTTCCCGACCCTCTGTCATCAGCCCACGGGGGCCAAGGCAACATACAGGGTGCCCAGTCAGGCAAAGGGCCCTAATTTGTGCCCAGGGAAACTTAAGGAGACCCTGATTCAGAACATCTTGGATACTCGTCTGAAAGGGGTTGTTAGAGGCGGAAGGGGAGGATGTTGGGTTGTAACTGCCCTAACCCCTGTGCTTCTCTCAGGCCTGGGATCCTGCCCAAGCAAAAGTGGTCCTTAGGAGAGCGGCTCCTGGGTTACAGAGTAGGCGCAATCTCTGACTGGTGGTGGAGTGGAGGGGAGGGTTAAATAGTACAACAGGGCAGTGGGTAGGACAGCCCGGAGTCTCCTAGACCCTCCCTCCAAATCCAGGGGGATTTTGCTGTGTGCTGTGTAGCCCTGACCTCCCTCCTCCAGACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGGTGGGAAGAGAAAATGAAGCGTGGGAGTCAAGAATGGGGTTGATTTGGAGATTCAGTGTGTGACCTCCATCCTCAAATTTTCTATTGCCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGTGCTGAGAAGGAAGGGGTGGCAGGGATGTGGACCCGAGACGGTGGGAGCAGGAATGGGAGGGGACTAGGCTACTAGGGCCCCACTAGAGAAAGGAGAGGGAAAGGGCTTCTCACTTTCCCTTCCCAGGTCACAGAGTGGCCGAGAGGCAGGGAAAATAGAAGGCAGGCCCAAGGCCTCCAGCTCCACGTCCACCTCTAACATGGTCCCCTCCACAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCAGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGTAAGTGGGAGAGGGGGGCTGCCCTCTGCTCTCTTGCAGGGGCAGTTGTGGCAACAGGCATCTCACCTGATAATCTCCAGTCTGCTCCATCCAGGCTGAACAAGGGCCAATGACCTCTTTAGGCCCAGAATGGGATGGCAAAGGGAGGGTTACTGGTGATTCTCTGCCTGCACATCTTTGTGCTGATGAGGGACAGCACTGGGCACATGGTCCTCTGAGGGGAAGTTACAGTAGTAGAGGCGGAGTGCGCCTGTAACTGGCCTCTGGCCTGTGCATTCTTTCACAGGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGGTAAAGCATAGGCACAGCACATTCCCCCTACACATTAAAACTCAAGGTGGAGGGGTCAACGGGGCGGACTGGACCCAGGGTGTGCTCCTCATTTCCACACAGTGGTGGAGGGAAGGGATAGGAACAGAACATGGAGGGAGGCTCAGCAGGCTCCCAGGACACATGCACTTGAGGCCCAAAAGGACCTCTGCTCCCCCAGTCACTTGATGCGGGAAAACATGCACCTTCTTAGGGAAGATCTAGGAGAAAGGAAACAGTAAGCCACTGCTTCTTGGAAAATCTTCTGGGGGTCTGACCTGCTGGGACTGTTCCCTTTCCTCTTGCCCCGTAAGATTCCTAGGGCGGGGGGGGGGGGGGTCACTCTTTTCTGATCTACATTCTGATCTTGGGACTTCTTTCAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTCCCCTTGTGTTTTGTTGTCTCACATTTAGATATCAGCCATGCATGACTGAATGGCTTCCAATCATATACTCACCTATCACCTACAAGAGAACAATGAAAAACACACACAAAAACAAAATCTTGAATTTTGTAATCATGCCTATTGCTATTTCTTGAGCATAAGAATGGCTCAGATACTTTCCAAGACATAAAAGGAAGGCAGAGGAATAGTTGTTGCTGTAAAAGACATCAAGAATAAATGGGTCATGTACAACGGGAGGGGCCGGTTACCTGAATAATGGAGTGGAGATTGAGCTATCCTAGCTCCTCTGCTCACTAACTGACCTGTCGCATGACCGTGGACAAAACCCTGAACGCAGCTGTTTGTTTGCTAAACTTCTCTGGACCATGGCCTGCGGCATATCTATAGGCATCCTGTGTTTTCCACCCAGTTTCCTTCTTCCTCGCTAAGCCAACGTGGAAAGGGCTGGCCGTGAATATGCAGACAAGGTAACGAAAGTAAACCGTCAATTAGTAAAAGTACTTTATTTTCCTCTTGTATTTGCTTTATATCTTGCTTTACAAAGTTACGAAGTTCACAGCTTTATACCAAAATGTAAGAAGGCTATTTGCTTATAAACATTTTTGCAGTCAGGTGTCATCTGATTTCATTCTTCT