ID
stringlengths
13
17
question
stringlengths
88
1.13k
answer
stringlengths
6
156
reference_sequence
stringlengths
4.1k
4.1k
variant_sequence
stringlengths
4.1k
4.1k
Task1_train_22400
Here is a variant affecting ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; not provided
ATTCGTTATTTGGTTTGCAGCTGCAGGTTGGGTGCAGCTGGCAGACAGGCAGGCAGGGAGGAACTGAATTTGCTGAACACCCAACTGTATGTGCCAGGCTTTTCACACAGTGTCTCATTCATTGCAGAGTGAGCATTCGCGTCATTCATCAGTTAGTGGTGAGAACATCCAAGGCTCGGGGGATTCAGCAGCTGTCCTGAGTGCCACAGTAAGTGATAGAGCCTGGATTTAAACCCATCTTTGCTTGACTCTAAAGCTTGAGACAGAAACAGCCCATCCTCGGAGTCAAGTGAACTTAGAGAAGACCTAGGACAATTGTCGGGGACAGTGGTAGCCATGGGTTTTGTTGTTTGTTTTTTGAGATGGAGTCTCTCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCGCTGCAACCTCTGCCTCCCGGGCTCAAGCAATCCTCCCGCCTCATCCTCCCAAGAAGCTGGGATTACAAGCATGCGCCACCACACTGGCTAAATTTTTGTATTTTTAGTAGACGGAGTTTCACCATGTTGACCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGTGATTAGATGTGTGAGCCACCATGCCTAGCCCTAGCCATGGTTTTTATCTGACTACCATGTTTTCTACTTCTGGTTTCCTGTGGGAAAGGGCTGGGTTGGGGTGCTGTCAATCATGGGACCTGATCAGAGAGGTGGTCACATGATGCAGCCTAGTGTATCAGAATCTACTATCCATTCAGTTACTGTGACGAGTTCAGAGATGGACACATGATCCACAAAGGGCCAATCAGAACCTTCCCTGGGATTAATATATGACTACTGAGCTGAAGAAACGTTTTTTGCATGTTGAGTTGCTAAGGTGAGATGATATGATAGCTAGTGGCCATAAGACCTGCCCTGGAAAGAGAGCGTGTACAAAATTAGACCAGAGGTAAGCCAGTGGTTCCTAAACATTTGTGTACATCAGAATTACTTGGAGGGTTAATTAAAACCTAGATTCATGGGCCGACCCACATAGTATCTGAGGCAGTAGTCCTGGGCTGGGGCCTAAGAATGTACTTTGCTAACTAGTCCCCAGGTGATACTACTGCTGGTCCTGGGGTCACACTTTGAGAAGCACTGAGTGAAGATATGGAGAGAGTCACTGTGTCCTGATGACAACTGGGCCCATGCCCCCAAGGAAATATAAGCCATTAAATTCTATTCTTTTGGTTAAGCTAATTTTAGTTGGTTGCTGGTCCCAGCAATTGAAAGAATCTAGCTTCATATAATAGCCTTTGAGACCTTGCAATGCCTTTTTGGCTTCCAGATAATTGGAGAGGAAGAAATTACGGCAGGATAAAAACATTACGCGTGAAAGGCTCTGGCCCTTAATATTTAACTGTGCCGTGGGGCACAGGGGCTCATGCCCTGTAATCCCAGAACTTTGGGAGGCCAAGGTGGGAGGATCACTTGGGGCCAGGAATTCGAGACCAGCCTGGGCAACACAGGAAGACACTTGTCCTACAAAAATAAATTTAAAAATTAGCCAGTCATGGTGGCACGTGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGTAGGAGGATCACCTGAACCCAGGAGTTCAAGGCTGCAGGGAGCTATGATCACCTATTGCACTTCAGCCTTGGCAGGAGAGCAAGATTCTGTCTCTCTAAAAAAAAGAACTTTGATGTGAACATTTAGAGACAGACACTAGTGGAGATACCAGAAAGACTGTAGTGTCCCTGTCCCTGGGAATTCTAGGAACAGCCCCTAGATGTCCAGCTGGGTGAAACCTCATATATGGAGTCTTCCCCAGAGACAGGGGACTGGCTGAGTTGACCTCAGCCGGTCCCGGAAGCCTCCCTGACCTCTCCGTACCTGAAACCCAGCGTAGAGGAGAAACAGTGGCAGGATGGCCACAGTGGCCAGTGGGGTAGCCACTGCCACCACCAGGCTGACCTCCAGGAGTCCAAAGGCGTACATCAGCAGGGACCGGAGTTTGTCTGGAATGTCCACGTCAACCGTGTCTGTCTCCTTGGAGAAGCGGTTTAGCAGGTGACCAATGGGTGTCCGCTCAAAGAAGCTGATGGGAGATCGCACCACATCCCACAGGAGCCTCTGGAAGAGCAACCTGGATGCCCGGGCCCCACCTAGGAGCACCGCAGCCATGGAGGCAAACAGCCCAATGGCTGGGGAGGGAGAGGAGGTAAGAGCATGAGGGCTGGAGACCCTCAGGAGCGGCCCACGGGGCCCTGCGCAGGTCTCTCCCGCTACCCCATGGTGGACATCTTATGGCTTGGCCACCCTGATTATTATATTTTTTTGAGACAGGGTCTCACTCTGTCACCCATGTTGAAGTGCAGTAGCATGATGATGGCTCAGTGCAGCCTTGACCTCCTGCACTCAAGCGATCCTCCCGCCTCACCCTCCGAGTAGCTGGGACCACAGGTGTACGCCACCATGCCGGCTAATTTGGGGTATTTTTGTAGAGATGGGATCTTGCTATGCTGTCCAGGCTGGTCTCGAACTCCTGGGATCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGAGATGACAGGCATGAGCCACTGCGCCTGTACCCTGCTTGTTTCTTGATGTAATGGGTTGAAGAGTGTCCCCCAAAATTCATTTGGGATGGGTCCTAAATTCAGTGACTGCCATTTATATAAGAATACTAGAGGATACTCAGAGACACAGCAGGAGATATGAAGATGGCGACACAGATGGGAGGGTGTATCTACAAGCCAAGGAATGCCAGCGACTGCCGGCGACCACCAGAAACCAGGAGAGAAGCCTGGGGCGTATTCTCCATCAGAACCTCCACGAGGGGCCGGGCACAGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGAGCAACACGGTGAAACCCTACTAAACCCTACTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGGCACCTGTAGTCCTAGCTACTCAGGAGGCTGAGTCAGGAGAAACACTGGAACCCAGGAGGCAGAGGTTGCAGTGAGCCATAAGCCGAGATCGTGCTACTGCACTCCAGCCTGGTTGACAGAGCAAGACTCCGTCTCAGAAAAAACAAACAAACAAACAAAAAAACCAAAAAAACCTCCACAAAGAGTTAACACTGCTGACACCTTGATTTTAGACTTCAGGCCTCAGAACTGCGACAGAACAAATTTCAATTGTGCTGGGCTCCCAAGTTTGTGGCAACTTGTTTGGCAGTAGCCCTGTGAGAGAAATGCACATCCTTCCTCCCAGTGCTAATCTGTATGCCTGGGGTGGGGCTAACTTCTCCTCTGGGGTGGGGCAAATTTCACCCATGGCCAATCCAAACCACTGCAGTTGGTTCAGGGATGAACACATAACCCAAGTCAGGCCAATGACAGGGAGACCTGGGACTTCACTAGAACTTTTGGAAAAGTGGTACTTGGTTGTTGGAGGTAGCCAAGCTGGAGCCGTGGAATATCATCTTACTGCCAGGGGGAGCAGCTAAGCTGGACAGGAAGCTGTCACAGAGGAGGGAAATAAAGCGATTTCTTGTTTGGACCCCTACATCCAGCCATACCTGAAGCCAGAAATCTAGGGATACTGGTCCCAAGAGCCAATCAATTCTCTTGTTGCTTAAACACTTTGAATTGGAGCTGAATTTGTTTATTTTCAGACGGAGTCCTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCTGCTCACTGCAAACCCCACCTCCCAGGTTCAAGCGATTCTCCTTCCTCAGCCTCCCAAGTAGCTGGGATTACAAACACTGACACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTCGCCAGGCTGATCTTGAACTCCTGACCTCAAGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTATCTGGCCTGGAGCTGAATTTTTTATTC
ATTCGTTATTTGGTTTGCAGCTGCAGGTTGGGTGCAGCTGGCAGACAGGCAGGCAGGGAGGAACTGAATTTGCTGAACACCCAACTGTATGTGCCAGGCTTTTCACACAGTGTCTCATTCATTGCAGAGTGAGCATTCGCGTCATTCATCAGTTAGTGGTGAGAACATCCAAGGCTCGGGGGATTCAGCAGCTGTCCTGAGTGCCACAGTAAGTGATAGAGCCTGGATTTAAACCCATCTTTGCTTGACTCTAAAGCTTGAGACAGAAACAGCCCATCCTCGGAGTCAAGTGAACTTAGAGAAGACCTAGGACAATTGTCGGGGACAGTGGTAGCCATGGGTTTTGTTGTTTGTTTTTTGAGATGGAGTCTCTCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCGCTGCAACCTCTGCCTCCCGGGCTCAAGCAATCCTCCCGCCTCATCCTCCCAAGAAGCTGGGATTACAAGCATGCGCCACCACACTGGCTAAATTTTTGTATTTTTAGTAGACGGAGTTTCACCATGTTGACCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGTGATTAGATGTGTGAGCCACCATGCCTAGCCCTAGCCATGGTTTTTATCTGACTACCATGTTTTCTACTTCTGGTTTCCTGTGGGAAAGGGCTGGGTTGGGGTGCTGTCAATCATGGGACCTGATCAGAGAGGTGGTCACATGATGCAGCCTAGTGTATCAGAATCTACTATCCATTCAGTTACTGTGACGAGTTCAGAGATGGACACATGATCCACAAAGGGCCAATCAGAACCTTCCCTGGGATTAATATATGACTACTGAGCTGAAGAAACGTTTTTTGCATGTTGAGTTGCTAAGGTGAGATGATATGATAGCTAGTGGCCATAAGACCTGCCCTGGAAAGAGAGCGTGTACAAAATTAGACCAGAGGTAAGCCAGTGGTTCCTAAACATTTGTGTACATCAGAATTACTTGGAGGGTTAATTAAAACCTAGATTCATGGGCCGACCCACATAGTATCTGAGGCAGTAGTCCTGGGCTGGGGCCTAAGAATGTACTTTGCTAACTAGTCCCCAGGTGATACTACTGCTGGTCCTGGGGTCACACTTTGAGAAGCACTGAGTGAAGATATGGAGAGAGTCACTGTGTCCTGATGACAACTGGGCCCATGCCCCCAAGGAAATATAAGCCATTAAATTCTATTCTTTTGGTTAAGCTAATTTTAGTTGGTTGCTGGTCCCAGCAATTGAAAGAATCTAGCTTCATATAATAGCCTTTGAGACCTTGCAATGCCTTTTTGGCTTCCAGATAATTGGAGAGGAAGAAATTACGGCAGGATAAAAACATTACGCGTGAAAGGCTCTGGCCCTTAATATTTAACTGTGCCGTGGGGCACAGGGGCTCATGCCCTGTAATCCCAGAACTTTGGGAGGCCAAGGTGGGAGGATCACTTGGGGCCAGGAATTCGAGACCAGCCTGGGCAACACAGGAAGACACTTGTCCTACAAAAATAAATTTAAAAATTAGCCAGTCATGGTGGCACGTGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGTAGGAGGATCACCTGAACCCAGGAGTTCAAGGCTGCAGGGAGCTATGATCACCTATTGCACTTCAGCCTTGGCAGGAGAGCAAGATTCTGTCTCTCTAAAAAAAAGAACTTTGATGTGAACATTTAGAGACAGACACTAGTGGAGATACCAGAAAGACTGTAGTGTCCCTGTCCCTGGGAATTCTAGGAACAGCCCCTAGATGTCCAGCTGGGTGAAACCTCATATATGGAGTCTTCCCCAGAGACAGGGGACTGGCTGAGTTGACCTCAGCCGGTCCCGGAAGCCTCCCTGACCTCTCCGTACCTGAAACCCAGCGTAGAGGAGAAACAGTGGCAGGATGGCCACAGTGGCCAGTGGGGTAGCCACTGCCACCACCAGGCTGACCTCCAGGAGTCCAAAGGCGTACATCAGCAGGGACCGGCGTTTGTCTGGAATGTCCACGTCAACCGTGTCTGTCTCCTTGGAGAAGCGGTTTAGCAGGTGACCAATGGGTGTCCGCTCAAAGAAGCTGATGGGAGATCGCACCACATCCCACAGGAGCCTCTGGAAGAGCAACCTGGATGCCCGGGCCCCACCTAGGAGCACCGCAGCCATGGAGGCAAACAGCCCAATGGCTGGGGAGGGAGAGGAGGTAAGAGCATGAGGGCTGGAGACCCTCAGGAGCGGCCCACGGGGCCCTGCGCAGGTCTCTCCCGCTACCCCATGGTGGACATCTTATGGCTTGGCCACCCTGATTATTATATTTTTTTGAGACAGGGTCTCACTCTGTCACCCATGTTGAAGTGCAGTAGCATGATGATGGCTCAGTGCAGCCTTGACCTCCTGCACTCAAGCGATCCTCCCGCCTCACCCTCCGAGTAGCTGGGACCACAGGTGTACGCCACCATGCCGGCTAATTTGGGGTATTTTTGTAGAGATGGGATCTTGCTATGCTGTCCAGGCTGGTCTCGAACTCCTGGGATCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGAGATGACAGGCATGAGCCACTGCGCCTGTACCCTGCTTGTTTCTTGATGTAATGGGTTGAAGAGTGTCCCCCAAAATTCATTTGGGATGGGTCCTAAATTCAGTGACTGCCATTTATATAAGAATACTAGAGGATACTCAGAGACACAGCAGGAGATATGAAGATGGCGACACAGATGGGAGGGTGTATCTACAAGCCAAGGAATGCCAGCGACTGCCGGCGACCACCAGAAACCAGGAGAGAAGCCTGGGGCGTATTCTCCATCAGAACCTCCACGAGGGGCCGGGCACAGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGAGCAACACGGTGAAACCCTACTAAACCCTACTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGGCACCTGTAGTCCTAGCTACTCAGGAGGCTGAGTCAGGAGAAACACTGGAACCCAGGAGGCAGAGGTTGCAGTGAGCCATAAGCCGAGATCGTGCTACTGCACTCCAGCCTGGTTGACAGAGCAAGACTCCGTCTCAGAAAAAACAAACAAACAAACAAAAAAACCAAAAAAACCTCCACAAAGAGTTAACACTGCTGACACCTTGATTTTAGACTTCAGGCCTCAGAACTGCGACAGAACAAATTTCAATTGTGCTGGGCTCCCAAGTTTGTGGCAACTTGTTTGGCAGTAGCCCTGTGAGAGAAATGCACATCCTTCCTCCCAGTGCTAATCTGTATGCCTGGGGTGGGGCTAACTTCTCCTCTGGGGTGGGGCAAATTTCACCCATGGCCAATCCAAACCACTGCAGTTGGTTCAGGGATGAACACATAACCCAAGTCAGGCCAATGACAGGGAGACCTGGGACTTCACTAGAACTTTTGGAAAAGTGGTACTTGGTTGTTGGAGGTAGCCAAGCTGGAGCCGTGGAATATCATCTTACTGCCAGGGGGAGCAGCTAAGCTGGACAGGAAGCTGTCACAGAGGAGGGAAATAAAGCGATTTCTTGTTTGGACCCCTACATCCAGCCATACCTGAAGCCAGAAATCTAGGGATACTGGTCCCAAGAGCCAATCAATTCTCTTGTTGCTTAAACACTTTGAATTGGAGCTGAATTTGTTTATTTTCAGACGGAGTCCTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCTGCTCACTGCAAACCCCACCTCCCAGGTTCAAGCGATTCTCCTTCCTCAGCCTCCCAAGTAGCTGGGATTACAAACACTGACACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTCGCCAGGCTGATCTTGAACTCCTGACCTCAAGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTATCTGGCCTGGAGCTGAATTTTTTATTC
Task1_train_22401
Given this variant in gene ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; not provided
ACACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTCGCCAGGCTGATCTTGAACTCCTGACCTCAAGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTATCTGGCCTGGAGCTGAATTTTTTATTCTTTGTATTCGAGAGTCATAACCAATTTCTCTCTCTCAGCTCCCATCTCTCCATCTTTAGGGGAGAGTAAGACTTGCCCTTAGCTATCAAATGAGGGATGGAAGTGGAAGGATTTTGAAAGGGCTATTTGCCACCCAAATGAGGATTTGGGTTAATTCCAGGGCTCGGCTGACTCTGAGAATCCCTAATTTCCTCTTGGTTAAGTAACCATTCGCCTTGAGTATTCCACTGTACATGCAGTTGTGGTGAGTAGGTGTACAGGTTCTTAGGACTAGAAGAGTCCTCAAGTTCAGGCCTGGCGCCCCCTATTTTACAGGGGAGGTCACAGGCTCACAGCATTTTGGTGATGTGGCCAATGTCACCCAGTGAATGAGGACGAATCAACATGAAAACGAGGCAACTGTCCTTTAAAGATGAAGCCAGGCCGGGCGTGGTGGCTCATGCCTGTGATCCCAACACTTTGGGAGGTTGAGGCGGAGGATTGCCTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACACGGCGAAACCGTCTCTATCAAAAACAAAAATTAGCCAGCATGGTGGCATGTGCATGTAGTCCCAGCTACTCGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCCGAGTTCGTGCCACTGCATTCCAGCCTGGGTGACAAAGCCAGACCCAGTCTATATATATGTGTGTGTGTGTATAAATAAGAAGCCAAACTCACATGTGCACTCCTGTTACTCCCTTCAGCCAGGCCACGTATTAAAAGGAGAAGAACCAGGGGTTGGGGACAGGGTGGGCGAGGCAGGAGAAGGGTGGGTGTGGTTGCAAAAGGGCAACACGAGAGCGCCTCGTGGTGAGGGGGTTGTTCAGTATCTCAACTGTCAACCATCGTGATGGATGCGAGAGACTGAACAGGGGATACGACTGCACAGAGGCAAACATGCGCACACCCACGTGCAAGCAAAACTGGGGAAATCACAATGAGATCCATAGGGCCGGGTGCGGGGGCTCACACCTGTAATCCCAACACTCTGGGAGGCCGAGGCGGGCAGATCATTTGAGGTCAGGAGTTCGAGACCAGCTTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAACCAGGCTGCACACTTGTAATCCCAGCTTCCAGCTACTCAGGAAGCTGAGGTAGGAGAACTGCTTGAACCTCGGAGATGGGGGTTGCAGTGAGCCGAGACGGCAGCACTGCCCTCCAGCCCGGGCAACAGAGCAAGACTCTGTCTCAAAATAAAATAAACAAATAAATAAATAAATAAATAATTGAGATCCATGGATTGATGGGTGTCAGGATCCTTTGTGTGATACTTTACTATCAGTTTGCAAAATATCACCAATGGGAGAAACTGGGCAGACTGTTCAAGGTAGCTGGCTGCCTTATTTCCTAGAACTGCATGTGAATCTACAATTATTTCAAGAAGAAGTCTTTCCATTTTTGAGGAGGAGAAGAAGGAGTGATAGCGGTGATGCATTTGTTAGGGAGGGTCTGGCTCTGTCTGGAGGTTTGGGGGCAGGCACTGAAAGCCACCAGCAGGCAGGCCTTGCAGACGCCTTCCGCTAGTGGGGAGGGACTGGGAGAGGTTCTGAAGCTTCCAGAAAAGGAGGGATGTGCCCTGTCCTTCCCGTTCCCTCCAGCCTCATCTTAAGGACGCAGATCTTTGCCTGGACCCCAGACGTTTTGCACACTGTTCCAGGGGGACAGGGTGACCCAGGGAGGGGTGGGGTAAAGGAGTCCTGAGCACCCCTTGGTGCAGCTGGGAGGAGAGGGATGAGGAGGGCAGGTGAGGCGTACCTTGGAGACAGCCGAGGAGCCCGAAGATCCCGCCACGCAGGGCTGCCTGCGTCTGCTGCCCACCTACTGCAGGGTCGTCCGCCCACAGGCTCAGCCAGTAGCCCCGGCAGAAGGAGGCCACTTGCTGGCAGAGGAAGAGGAAGAGTGCGTAGAGGCAGAGGGGGGTGCCCACGGCACGCAGGTAGGCCAGGTGCACTGTGGCCTTCACCTGTAGCACACATGAGGGAGAGGGAGGCAGAGAGAGCCCCCAGTGGGAGGGGTGGGTTGAGGCAAGGCCAGGCGAGGCTCCCAGAAAACATGCCCATGGCAGATGGGACCACCACGCAGACCTCACTGGTTCTCCCGCTGTGCCTCCCACCAGAAGCACCATTTCCCCGACAGGCCCCAGCCAGCCTTAGAACCCCCATCTCCTATACAATCCCCAGGGAGCTAGTATTAATATTTTTTCTTTTGTTTTTTTTTTGAGGACAGGGTCTTGCTTTGTCGCCCATGTCACCCAGGCTGGAGTACACTGGCATGATCATGGCTCACTGCAGCCTTGAACTCCTAGGCTCAAGTAATCCCCCCGCCTCAGCCTCCCGAGTAGTCAGGACTATAGGTTTGTACCACCATGTTTTGTTAATTTTCATAGTTTTAAAGAGATGGAATCTCGCTGTGTTGCCCAGGCTAGTCTCAGACTCCTGGCCTCAAGTGATCCTCCCTCCTCGGCCTTCCAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCCAGCTAGAAGGGTTTTCTTGAACACCCACCATAGGTCAGGCATGTGTCTCTCCTTATAACAACCTCCATTTCACAGATAAGGAAACTGAGGCACAGAGAGGTTCAGCCACTGGCTTAAGGTCCTGCTCCTACAAATCTGAAGTTCTCTGCACAGCTGCAGCCAGACGGGACTGTTGAAAACATTAATCTAATTATATCTTGTCGTTGGCCTGTCCATGGCTATCTCTTGCTCTTAGAAGAAATCCCAGCCAGGAGGGGTGGCTCATACCTGTAAGCACTTTGGGAGGCCAAGGCGGGTGTGTCACCTGAGCTCAGGAGTTTGAGACCAGCCTGGACCAACGTAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCACGTGTGGTGGCAGGCACCTGTAGTCCCAGCTACTCGAGAGGCTAAGGCAAGAGAATCGTTTGAAGCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATTGCACCATTACACTCTTCTCTGGGCGACAAGAGTGAAACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAATTCCAAGCTTCTTATCTCGCCCCCACTCACTGCCTGCCAGCCTCATGGGACCCCTTTCTCTGGCACCCTAAGCTACTTCCCACCTCGGAGCCATTGCACCTGCTGCTCTCTCTGCCTGGAGCGCTCTTTCTCCTGCCCTTTGTATGACTGGTTCCTTCACACATTCTTTGGGGAAGCTCAAATGTCACTTCTCAGAGCATCCTGTCCATACCAACCATGGTAGGGTTTCTCAGTGGTCTCTATTTCATCATTCTTTCTTTTAAGAGGCAGGGTCTCACTCTGTCACCCAGGCTGGATTGCAGTGACATGATCATAGCTCACTGCAGCCTCGAACTCCTGGCCTCAAGCAATCCTCCTGCCTCAGCCTCTGAAAGTGTTGGGATTACAGGCATGAGCCACTGCGCCTGATCATTCTTATTTTCTTTATAGCACTTATTGTTATTGGACATAGCTTACTTATTAGCATAATTATTTACTCTCCGTCTATCCTCACTAGTGTCTAATCTCTACCAGACTTAGCCTGGCACATAGTGGGTATTGTGTACATGTTTGCTGGATGGATGAGAGGGTAGGTGGGTGAATAAATGAGCGGGTGGGTAGGTAGGTAGGTGTGTGAATGAGTGGATGAATGGATGGAAAGATCAATGAATGGATGAACAGCTGAACAGACAGATGCATAGGTGAGGGAATGGTTGGATGTATTGTTAGGTGGGATAGATGGATGGGTAAGCGAATGGGATG
ACACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTCGCCAGGCTGATCTTGAACTCCTGACCTCAAGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTATCTGGCCTGGAGCTGAATTTTTTATTCTTTGTATTCGAGAGTCATAACCAATTTCTCTCTCTCAGCTCCCATCTCTCCATCTTTAGGGGAGAGTAAGACTTGCCCTTAGCTATCAAATGAGGGATGGAAGTGGAAGGATTTTGAAAGGGCTATTTGCCACCCAAATGAGGATTTGGGTTAATTCCAGGGCTCGGCTGACTCTGAGAATCCCTAATTTCCTCTTGGTTAAGTAACCATTCGCCTTGAGTATTCCACTGTACATGCAGTTGTGGTGAGTAGGTGTACAGGTTCTTAGGACTAGAAGAGTCCTCAAGTTCAGGCCTGGCGCCCCCTATTTTACAGGGGAGGTCACAGGCTCACAGCATTTTGGTGATGTGGCCAATGTCACCCAGTGAATGAGGACGAATCAACATGAAAACGAGGCAACTGTCCTTTAAAGATGAAGCCAGGCCGGGCGTGGTGGCTCATGCCTGTGATCCCAACACTTTGGGAGGTTGAGGCGGAGGATTGCCTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACACGGCGAAACCGTCTCTATCAAAAACAAAAATTAGCCAGCATGGTGGCATGTGCATGTAGTCCCAGCTACTCGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCCGAGTTCGTGCCACTGCATTCCAGCCTGGGTGACAAAGCCAGACCCAGTCTATATATATGTGTGTGTGTGTATAAATAAGAAGCCAAACTCACATGTGCACTCCTGTTACTCCCTTCAGCCAGGCCACGTATTAAAAGGAGAAGAACCAGGGGTTGGGGACAGGGTGGGCGAGGCAGGAGAAGGGTGGGTGTGGTTGCAAAAGGGCAACACGAGAGCGCCTCGTGGTGAGGGGGTTGTTCAGTATCTCAACTGTCAACCATCGTGATGGATGCGAGAGACTGAACAGGGGATACGACTGCACAGAGGCAAACATGCGCACACCCACGTGCAAGCAAAACTGGGGAAATCACAATGAGATCCATAGGGCCGGGTGCGGGGGCTCACACCTGTAATCCCAACACTCTGGGAGGCCGAGGCGGGCAGATCATTTGAGGTCAGGAGTTCGAGACCAGCTTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAACCAGGCTGCACACTTGTAATCCCAGCTTCCAGCTACTCAGGAAGCTGAGGTAGGAGAACTGCTTGAACCTCGGAGATGGGGGTTGCAGTGAGCCGAGACGGCAGCACTGCCCTCCAGCCCGGGCAACAGAGCAAGACTCTGTCTCAAAATAAAATAAACAAATAAATAAATAAATAAATAATTGAGATCCATGGATTGATGGGTGTCAGGATCCTTTGTGTGATACTTTACTATCAGTTTGCAAAATATCACCAATGGGAGAAACTGGGCAGACTGTTCAAGGTAGCTGGCTGCCTTATTTCCTAGAACTGCATGTGAATCTACAATTATTTCAAGAAGAAGTCTTTCCATTTTTGAGGAGGAGAAGAAGGAGTGATAGCGGTGATGCATTTGTTAGGGAGGGTCTGGCTCTGTCTGGAGGTTTGGGGGCAGGCACTGAAAGCCACCAGCAGGCAGGCCTTGCAGACGCCTTCCGCTAGTGGGGAGGGACTGGGAGAGGTTCTGAAGCTTCCAGAAAAGGAGGGATGTGCCCTGTCCTTCCCGTTCCCTCCAGCCTCATCTTAAGGACGCAGATCTTTGCCTGGACCCCAGACGTTTTGCACACTGTTCCAGGGGGACAGGGTGACCCAGGGAGGGGTGGGGTAAAGGAGTCCTGAGCACCCCTTGGTGCAGCTGGGAGGAGAGGGATGAGGAGGGCAGGTGAGGCGTACCTTGGAGACAGCCGAGGAGCCTGAAGATCCCGCCACGCAGGGCTGCCTGCGTCTGCTGCCCACCTACTGCAGGGTCGTCCGCCCACAGGCTCAGCCAGTAGCCCCGGCAGAAGGAGGCCACTTGCTGGCAGAGGAAGAGGAAGAGTGCGTAGAGGCAGAGGGGGGTGCCCACGGCACGCAGGTAGGCCAGGTGCACTGTGGCCTTCACCTGTAGCACACATGAGGGAGAGGGAGGCAGAGAGAGCCCCCAGTGGGAGGGGTGGGTTGAGGCAAGGCCAGGCGAGGCTCCCAGAAAACATGCCCATGGCAGATGGGACCACCACGCAGACCTCACTGGTTCTCCCGCTGTGCCTCCCACCAGAAGCACCATTTCCCCGACAGGCCCCAGCCAGCCTTAGAACCCCCATCTCCTATACAATCCCCAGGGAGCTAGTATTAATATTTTTTCTTTTGTTTTTTTTTTGAGGACAGGGTCTTGCTTTGTCGCCCATGTCACCCAGGCTGGAGTACACTGGCATGATCATGGCTCACTGCAGCCTTGAACTCCTAGGCTCAAGTAATCCCCCCGCCTCAGCCTCCCGAGTAGTCAGGACTATAGGTTTGTACCACCATGTTTTGTTAATTTTCATAGTTTTAAAGAGATGGAATCTCGCTGTGTTGCCCAGGCTAGTCTCAGACTCCTGGCCTCAAGTGATCCTCCCTCCTCGGCCTTCCAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCCAGCTAGAAGGGTTTTCTTGAACACCCACCATAGGTCAGGCATGTGTCTCTCCTTATAACAACCTCCATTTCACAGATAAGGAAACTGAGGCACAGAGAGGTTCAGCCACTGGCTTAAGGTCCTGCTCCTACAAATCTGAAGTTCTCTGCACAGCTGCAGCCAGACGGGACTGTTGAAAACATTAATCTAATTATATCTTGTCGTTGGCCTGTCCATGGCTATCTCTTGCTCTTAGAAGAAATCCCAGCCAGGAGGGGTGGCTCATACCTGTAAGCACTTTGGGAGGCCAAGGCGGGTGTGTCACCTGAGCTCAGGAGTTTGAGACCAGCCTGGACCAACGTAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCACGTGTGGTGGCAGGCACCTGTAGTCCCAGCTACTCGAGAGGCTAAGGCAAGAGAATCGTTTGAAGCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATTGCACCATTACACTCTTCTCTGGGCGACAAGAGTGAAACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAATTCCAAGCTTCTTATCTCGCCCCCACTCACTGCCTGCCAGCCTCATGGGACCCCTTTCTCTGGCACCCTAAGCTACTTCCCACCTCGGAGCCATTGCACCTGCTGCTCTCTCTGCCTGGAGCGCTCTTTCTCCTGCCCTTTGTATGACTGGTTCCTTCACACATTCTTTGGGGAAGCTCAAATGTCACTTCTCAGAGCATCCTGTCCATACCAACCATGGTAGGGTTTCTCAGTGGTCTCTATTTCATCATTCTTTCTTTTAAGAGGCAGGGTCTCACTCTGTCACCCAGGCTGGATTGCAGTGACATGATCATAGCTCACTGCAGCCTCGAACTCCTGGCCTCAAGCAATCCTCCTGCCTCAGCCTCTGAAAGTGTTGGGATTACAGGCATGAGCCACTGCGCCTGATCATTCTTATTTTCTTTATAGCACTTATTGTTATTGGACATAGCTTACTTATTAGCATAATTATTTACTCTCCGTCTATCCTCACTAGTGTCTAATCTCTACCAGACTTAGCCTGGCACATAGTGGGTATTGTGTACATGTTTGCTGGATGGATGAGAGGGTAGGTGGGTGAATAAATGAGCGGGTGGGTAGGTAGGTAGGTGTGTGAATGAGTGGATGAATGGATGGAAAGATCAATGAATGGATGAACAGCTGAACAGACAGATGCATAGGTGAGGGAATGGTTGGATGTATTGTTAGGTGGGATAGATGGATGGGTAAGCGAATGGGATG
Task1_train_22402
A variant found in Chromosome 16 affects ABCC6 (ATP binding cassette subfamily C member 6). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
CATAGCCAGCCTGTCAAAGCATAAGTGGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACC
CATAGCCAGCCTGTCAAAGCATAAGTGGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGGCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACC
Task1_train_22403
Here is a genetic alteration in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCATCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
Task1_train_22404
Chromosome 16 houses a mutation in gene ABCC6 (ATP binding cassette subfamily C member 6). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCATCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
Task1_train_22405
The following genetic variant occurs in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Pseudoxanthoma elasticum, forme fruste
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCATCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
Task1_train_22406
The gene ABCC6 (ATP binding cassette subfamily C member 6), on Chromosome 16, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; Arterial calcification, generalized, of infancy, 2
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCATCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
Task1_train_22407
A variant affecting Chromosome 16, within the gene ABCC6 (ATP binding cassette subfamily C member 6), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
GGCCAGGCCTGGCATGGTGGTTTACAGCTATGGGGAGGAACCAGTCCTGCCCTACTGCAGCATTCAGACAACTCCAGCAAGCTGGCCTCGGCCCACTTGAAGACATCCATCAATTGGAAGGCATATTGTTCATTCCATGAACTGGCCTTATAGGGGCCTAATCATCTTGGCTAACTGGACCAATTTTGGTAAATTATCCCTCAGCAGGGCACCATGGGGGGGACTTCAGCAGGTTCTCTATCCATAATGGTTTTGGTTGCCCGCCTAACTGCCCGAGATGCGGGTGGTCCCTTCAGCTACTTCAGCTTCAGCCTGTGCCCTTCTGAGTGTGGCACCATGGTGGACTCACCTCTCGCGTCTAAGCTCGGGCCTCCTGCCTGCAGAGGTGCCTCTGGGGTCCTTGGTGCTGGTCCCAGGTTCTGTTTCTGCAAGGTCAAGAGAGTCCTGTCACGCAACACGGCCCAGATACCCACTTTGACACCCACTGACTATGTGGCCTTAACCGCTCTGACCATCCATTTCCCCTGATCTGGCTCCTGCCACGTCTCCAGCAACCTCTCTCAACACCCCACTCTGAGTTCTTCCAGGAACATCCTTCAGGCATTCACTCACTCATTCATTTCTTCAATCAGTGATAACTGAGCACCTACTATGAACTTGAGGTTGGAAAAACAGCATTTAACACTGTACAAAGTCAAGTTACCTCTGTTTCCCCCAACAGCCTTGCTCAAGCAGTTCCTTGTGTCTGGAATGCTTTTTTCTGGCTAACTCTCACCTACCCTCAGGTACCATCTCCCCTAGGAAGGACACCTCCCCACCACTATCCCCCAGGTGTGGCCAGTAACTGAAAGCAAATCTGTAGTAGTTTAACCACAGACCTGTAAGCAACAAGTAACTGCTACTGTAAGCTGCTAGGATTTGGGGGGCTATTTGTTACACAGCATCATCACAGCAAAAGCTGACCAACACAAACAGGCAAGTTCTATCTTCAAGCTTCAGGACTGTGACATTGTGAATCAACACTTAAGGTTTTAACCAGGTTGGGCCAGTGCTAAGCAGATGTTCTCAGAAGAAGCAAAGCCTGAGATTGAGGGAGACCTGGATGTGAATCCTTGCTTTGTCATGAAGGGATAGTGTAGAGGGTAGCAATTAAAAAACACATTCTCTGGAATCAAGTTGCTTGGGTTCAAATCCCAGTGCTGCCACTTACAAGCCATGTAACCTGGGACTAGTTCCTTAACTTCTGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCCTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATC
Task1_train_22408
Here is a variant affecting ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
TGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCT
TGGGCCTCAGTTTCCTCATCTGTGAAATGGAAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAAAGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCT
Task1_train_22409
Gene ABCC6 (ATP binding cassette subfamily C member 6), found on Chromosome 16, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
AAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGA
AAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATTCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGA
Task1_train_22410
A variant has been detected on Chromosome 16 in ABCC6 (ATP binding cassette subfamily C member 6). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Pseudoxanthoma elasticum, forme fruste
AAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGA
AAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATTCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGA
Task1_train_22411
Gene ABCC6 (ATP binding cassette subfamily C member 6), found on Chromosome 16, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Arterial calcification, generalized, of infancy, 2
AAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGA
AAATGATTCTAGTACCAGCCTCACAGGGGCATTATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATTCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGA
Task1_train_22412
A mutation in ABCC6 (ATP binding cassette subfamily C member 6), located on Chromosome 16, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
TATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGT
TATGTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACATCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGT
Task1_train_22413
This variant affects the gene ABCC6 (ATP binding cassette subfamily C member 6) found on Chromosome 16. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
GTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAG
GTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCTGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAG
Task1_train_22414
Given this variant in gene ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
GTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAG
GTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCTGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAG
Task1_train_22415
A genetic alteration is present in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Pseudoxanthoma elasticum, forme fruste
GTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAG
GTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCTGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAG
Task1_train_22416
Consider this mutation in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Is this a benign change or a disease-causing variant?
Pathogenic; Arterial calcification, generalized, of infancy, 2
GTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAG
GTTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCTGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAG
Task1_train_22417
A variant was discovered on Chromosome 16, affecting ABCC6 (ATP binding cassette subfamily C member 6). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; not provided
TTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGG
TTGATTAAATGAGCTAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCAGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGG
Task1_train_22418
Here is a mutation in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
TAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCA
TAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCTGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCA
Task1_train_22419
This mutation is located in gene ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Pseudoxanthoma elasticum, forme fruste
TAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCA
TAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCTGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCA
Task1_train_22420
This alteration occurs within gene ABCC6 (ATP binding cassette subfamily C member 6) located on Chromosome 16. Is it associated with a disease or is it a benign variant?
Pathogenic; Arterial calcification, generalized, of infancy, 2
TAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCCGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCA
TAACCTCTGTGATGTGCTGTTAGTTGCTACTTTTCAGTCATTGTGAGTGAGCTTGGCTTGGCAACTTTACTTCCAGAACCTTGCCATGTATCCAGCACACTGTTTTTCTGGATTATTAGAAACCCTAGCTAGCATGGTGTAGCTTGCTAGGCATCAAAGTCCTTCTTGGGCTGTCTCCATAGCAACTGCAAGCATAGACTCTGGAGCTGGACATACTCAAGTTCTAATCTTGTGACCTTGGGCAAGTGATTTAACTCTCTTTGCCTCAGTTTGCTCATCTGTAAAATGACAGCAATAACTTCACATGCCTCTGGGGCATGTGTGAGAATCAAATGAAATAGTGTATTTTTTACAGAAGCACTTAGCACAACCCCTGGCTCATGGATGATGTTATCGGCTATTCTTGGAGAAAGGTGACCTATTAAGAGAGCTGTCTGCTTCCAGGCCTAGGCCTGCAGACAGGGTGTGGCCAGAGCACTCCATTCATGCCAGTAGGACCCTTCGAGCCTTTTCCCCCAAGGGTGGCAGGAGCCAGGCCTGGAGAATCAGCAAAGCCCACCTAGTACCTCCTTCTCCTCTATCTCCTGGCTGTCTGGCTTGATCCAGAAGACACATGAGGGCCCCCTTCCTCTGCAGAAGCTCCTGGTAGGAACCCATCTCTGCGATGGCCCCATTTGCCAGCACTATGATCCAATCAGCCTGGGGCAGGATGTGGAGTGCGTGCGTCACGAGAATCCGTGTCTGGGCAGGGAAGGGGTAGAAGTTACACACATGTGGCCGGGTGCAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAAGCCAAAGCATGTGGATCACTTGAGGCCAGAAGTTCGAGACCAGCCTGGCTGACACGGCTAAGCCCCATCTCTACTAAAAATACAAAAATTAGCTAGGTGAGGTGGCGCACACCTGTAGTCTCAGCTACTTTGGAGGCTAAGGCAAGAGAATCACTTAAACCTGGGAGGTGGAGCTTGCAGTGAGGCGAGATTGGACCACAGCACTCCATCCTGGGTGACAGAGCAAGACTCTGTCAAGAAAGGAAAGAAAGAAAGAGAAGAAAAGAAAGAAGAAAAGAAAAGAAACAAAGGAAGGAAGGAAAGAGAGAGAGAGAGAAAGAAAGAAAAAAAAAATGTACGGCCGAGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGATGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGCCGGAGCTTCCAGTGAGCGGAGATCGCACCACTGCCCTCCAGACTGAAAGACAGAGCGAGACTCCATCTCAAAAAAAAAAGAAAAAGAAAAAAGTTACACACATGTGCTTGGCCAGCCTCCTGAGCTGGGGGTTGGGGTGGGGGTATTGTCCCTGGACTCAGAGTGGGGACAGCTCCCCTTCTTGTGCTCCTGCCGCCTTTCTTGTAAACAGCATATCCAAATAGAGAAACAGAGGGGACTCCCTTAGCCTGTGTCTCAAAACAAGAAGACAAGGAGTACATCTGACCCTGGCCAATCATCCAAGGCAAAGCTGTAGTAGTTAAATCACAGATCCATAAGGAAGAAACACCTGCTGTTGTAAGCTGCTGGGATCTGGGGGTTGTTTGTTACATAGCATTGTCACAGCAAAAGCTGACCAATACAAAGAGGAAATTGGACTCAAGTGGAAGGGGGAGGTGAGATAAACTTGGGTTAGGACTGGATGCTAAGTGCTTCCTCTGCCTTTGCCCTGTACTGTCTGACACATGTTCCCAAACTTACTGTTCCCTGGAGTAGTCCACCAGGCCCAATGACCTGGTTGAAGACATGCTGGCCAACGTGGGCATCCAGGGCCGCCAGGGGGTCATCCAGCAGGTACACAGCTGCCTTTCTGTATACAGCCCGGGCCAGGCTCAGCTGCTGCTTCTGGCCTCCGGAGAGATTCATGCCCTGTGGCCACAAAAGGAACAGTGGCCTGAGTCAGCATCTACAGGGTGAAACTGGGGTGCCCAGGCTGTGGCAGGTCAGGGCACACCTGCCCATCAGGGTGAGGTACAGCTCAACATGCCTATTCCCTGGGGACAGGCCCAGCTTCCAAGGCACTCGCTCTCAAGCCAACAATGCCTCCATCCTTACCCGACCTCACTTCTCCACTTCCCAAGCACGCTTCCTGGAGGAGTTACCTACACTTCCCAATCCACTCTGTCTCCTCCTGCTCACTCTCTCTATCTCTTTGAGTCCAACTCTTGTTTCCCTTTCTCCACTGAGACCACCATCCATTTCCCTATTCCCTCATCCAGTGGCAGCTTTTCAGTCCTACTTTTGTATTTTAAATTTTAATTGTTTTCTTTTAGTTTTCATTGATATGTAATAGTTGTAACTATTCGAGGGGCACAAGTGGTATTTGGATACCTGTAGGGCAGTGGTCCCCAGCCTTTTTGGCACCAGGGACCAGTTTTGTAGAAGACGATTTTTCCATGGACCTGGGGGCAGGGGGATGGCCCGGGGGATGGTTTCAGGACGATTCAAGCACATTACGTTGATTGTGCACTTCTATTATTATTATTACTGCTGTTGTCGTTGTTATTATTGAGATGGAGTTTTGCTCTTGTCACCCAGGCTGGGAGTGCAATGGCATGATCTTGACTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGCACCCACTACCACGCCTGGCTAGTTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGGTGGCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTACTTGTATTATTATTGCATTGTAATATATAATGACTCACCATCATGCAGTATCAGTGGGAGCCCTGAGCTTGTTTTCCTGAAACTAGATAGTCCCTTCTGGGGATGATGGGAGGCAGTGACAGATCATCAGGCATTAGATTCTCATAAGATCCCTCACATGTGCAGTTTACAGTAGGGTTTGTGCTCCTATGAGAATCTAATGCTGCCACTGATCTGACAGGAGGTGGAGCTCAGGCGGTGATGGGAACAATAAGGAATGGCTGTAAATACAGATGAAACCTCACTCGCCTGCCCTCTGCCCACCTCCTGCTGTGCTGCCTGCCCAGTTCCTAACAGGCCACAGACTGGTGCTGATCCATGGCCCGGGGGTTGGGGACCCCTGCTGTAGACAATATGTAATGATCAAATCAGGGTAACTGAGATAGTCATCACCTCAAATATTTATCTTTTGTATTGCGAACACAACCATCCTTCTCTTCTAGCTATCTTGAAATATACAAGTAAATGATCATTAACTATAATTTCCCTTGTGCACTATTGATTACTTTAACTTATTCCTTCTATCTAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCA
Task1_train_22421
A mutation on Chromosome 16 affecting ABCC6 (ATP binding cassette subfamily C member 6) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
TAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCAGGTGGAAAGTGCTATGAAGAATAAATAGTAAAGCAGGGGGAGCCAGGTTCAGGGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGCTGGGTGGATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAAAAAAAATTAGCCAGTTGTGGTGGTACATGGCTGTAATTCTAGCTACTCATGAGGCTGAGGTGGGAGGATTGCTTGAACTACTCATGAGGCTGAGGTGGGAGGAATGCTTGAACTCAGGAGGTGGAGGTTACAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGCAGGTGCAGGTGTAGGGTGCACTAACAATAGTAGGGTGGCTGTGGTGGTAGATAAGGTGGTCAGGAAAGGCCTCTCTGTGAAGGTGATAGAAGTGAGGGATGAGCCCTGGGGACTCCTGGGGAGAGCTTTCCAGCAGAGGGAACAGCAGTGCAAAGGCCCTGGGGCCAGAGTGTGCTGTGGGGGATCAGGGAATATCACAGAGACTAAGGTGGCTGCAGTAAAGCTGAGAGGTGATGATGGGAGATGGGGCTAATGGATACCAGAGCCAGGTCACAGGGACCTTGCCAGGGATTGTCATGACTTGGGCTTTGTCTCTGAGGTAAATGGGGAGATCACCTGAGGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCCAGGTATGGTGGCATGTGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGTGTGAGAATTGCTTGAACGTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCATCACTGCATGCCAGCCTGTGCAACAGAGCAAGACTCTGTCTCCAAAACAAAACAAAAAACAAAACCACAAGTGGTGGGCTGGATTTGGCTTGGGGTCACAGTTTGCCAACCCCTGCCCAATCCATAGCTCCAGATGCATATATCCTGTTTCTTGGACATCTCTGTCCAGACCCCTTGGTGAGGCCCAGAGAGGGGAAGCAATTACACCAACATTACTCAGCAAGGCAGGGCAGAGTAAGACAGGAGTCTAGGTCTTCTCACTCTCAGTTGTCAGAGAGCTCCTCACTGCCAATCCCTGCCACAACTCCCTGCCTCTCTCTTTGTGTCTATTTCTGCTTATCAATTAGTGATTACGTATTGAGCACCTAGCACGTGCTTGACGCTGAGCTGAGCCCTTTTTCTCCGCTACTTCCCTAACCATTCCTCTCATTTCTCCATCATACTGCCCATGATGAGTCGGGGACCCAAATGACTCCCAACTGCAATGTCTCCCTGTCCCAAAAAGACCCCCAAACTCTCACCTGCTCCCCAATTGAAGTGTGGATTCCCTCAGGGAAGCTGTCCACATCTGGCTGCAGGGCACAGGCTTCTAGTACTCTCTCCAGCCAGGGTGGGTCCAGCTCCTGCCCGAAGCACACATTCTCTACCACAGAGGTGTTCTGCACCCAGGCCTCCTGGGGCACGTAGGCCACAGCACCCTAAAACACAACTTACTTTGGTCACAGGAGGATGATGGGGACAGAGGTGGGATAGGTTTTGAGGAGCAGTGGGAGCTGGGCTCTCAGTGGTGGGTGAGAGGTGGAGAGAATGAGTGAAAGTGAACTTGGCTGGGATGGGGAGGGTGGGAAGGCAGCGAGGAAGTGGGACTTTCAGGATGGGGACATCCTAGCAGACAGGCTGGGGGTGGCCTCACCTCGATGCTCACGAACCCCTCCACCTTTGACAGCTCCCCAAGGAGGGCGGACAGCAGGGAGGACTTCCCTGCCCCCACTGGACCGACAACAGCCAGCAGACAGCCCTGGGGCACCGTGAGGTTTATTCTGGACACGCAAGAGGGGAGACATGACCTTGGTTAGGGTTCAGCCCGCCTCTGTGAGGAAGGATGAGCCCCAGACGGAGCTGAGCTTTCCTGCTCTGGGAGTCTCCAAGAGGACCTGTGGGGCTGTTCTTTTTCCCAGTCCTTGTCTAGCTATTTGAGGAACTATCCTGTGCACATCTGTGCATGTACACATGCACACAAAGCGTGCACACATGCATGCACATTTGCACACTCATACAAGCATGCTAGCATGCACAGCAACACAATGTGGGCACGCATCCACACACACACAAGTGCATGCACATACCCAATCAATCCATGCTCACACGCATACATGTGTGCACACATGCACACCACGCACACACACACAGGGTTGACTATAGCCTGAGGGTTTCACCAGCCTGGCCTCCTGCCTTGGCTCTTGCGATAAATAGGCTCTTTCCTCCCTCCCTCCCGCTACTCTTGGTCCCGCCCCACTCCTGTCCACGTCCCACAGCCCATCCTCCACCCAGTGACCAGAGGGATCTGTTAAAACCCAAGTCAGATCGTGACACTTCCCAGCTAAACCCGCCAGCACTCCCATTTCACTCAGGGTCAAAGCTAAAGTCCTGACGATCAGGAATGACATCTCCCGCCTCCTTCCGCTCTGTGCCTCAGCTGCTCGGCCCTGGCCTTGCTGACCTCCTTGCTGTTTCTTGAACACAAAAGGCCAGTGGTTCTCACCAGGGGGTGACTGCATCCCCCAGGAGTCATTTGGCAAGATCTAGAGATATTTTTGGATGTCACAACCAGTAGGGGGTGCTGCTGGCATCTAGTGGGTAGAGACTGGGGTCAGCTAAACATCCCACAATGCACACGACAGCCCCCAACAAAGGAGTTTCAGCCCAAAATATCAACCGTGCTGAGGTTGAGAAACCCAGGTCCAGGCACTCTCCTGCCCCAGGACCTTTGCTGATGCCATTCCCACCGCCTAGAAGGTTCTTCTCCCAGGCCGGGCACGGTGGCTCATGCCTGTAATCCTAGTCCTTTGGGAACTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGACGAACATGGTAAAACCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCATGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGAAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCCGCGTGATAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAACAGCTCTTCTCCCAGACACTCCTTCCTTATGATCTCGGCTTGAATGCAAAGCCTTCCCTCGCTAGACATGCCATCGTACTCTGTTCCCTTGCTCTGGTTTTCTGTTTGGGCCTCACCTCTATCAGCATGTCACCCCACGAGAGCAGGGCCCTTGTCTGTTTCCTTCGCCCTATCCCCAATACCTAGAACAGAGCGTGGCCCATACCTAGTGCTCTATCGATGAAGTGAGTGAATGACAACCAATACAAATACTACCTGGGGCATATTCCTTCTCTTCTTAGGGAGTTTCAGGGCTGTCTGAGATTTTTGGCCACAAAGACCAA
TAGGCCTTCTTGTCTTTCATTCATTCTTTTAAAACTTATTTTTATTTATTTTTGAGATGGAGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCAGGTGGAAAGTGCTATGAAGAATAAATAGTAAAGCAGGGGGAGCCAGGTTCAGGGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGCTGGGTGGATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAAAAAAAATTAGCCAGTTGTGGTGGTACATGGCTGTAATTCTAGCTACTCATGAGGCTGAGGTGGGAGGATTGCTTGAACTACTCATGAGGCTGAGGTGGGAGGAATGCTTGAACTCAGGAGGTGGAGGTTACAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGCAGGTGCAGGTGTAGGGTGCACTAACAATAGTAGGGTGGCTGTGGTGGTAGATAAGGTGGTCAGGAAAGGCCTCTCTGTGAAGGTGATAGAAGTGAGGGATGAGCCCTGGGGACTCCTGGGGAGAGCTTTCCAGCAGAGGGAACAGCAGTGCAAAGGCCCTGGGGCCAGAGTGTGCTGTGGGGGATCAGGGAATATCACAGAGACTAAGGTGGCTGCAGTAAAGCTGAGAGGTGATGATGGGAGATGGGGCTAATGGATACCAGAGCCAGGTCACAGGGACCTTGCCAGGGATTGTCATGACTTGGGCTTTGTCTCTGAGGTAAATGGGGAGATCACCTGAGGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCCAGGTATGGTGGCATGTGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGTGTGAGAATTGCTTGAACGTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCATCACTGCATGCCAGCCTGTGCAACAGAGCAAGACTCTGTCTCCAAAACAAAACAAAAAACAAAACCACAAGTGGTGGGCTGGATTTGGCTTGGGGTCACAGTTTGCCAACCCCTGCCCAATCCATAGCTCCAGATGCATATATCCTGTTTCTTGGACATCTCTGTCCAGACCCCTTGGTGAGGCCCAGAGAGGGGAAGCAATTACACCAACATTACTCAGCAAGGCAGGGCAGAGTAAGACAGGAGTCTAGGTCTTCTCACTCTCAGTTGTCAGAGAGCTCCTCACTGCCAATCCCTGCCACAACTCCCTGCCTCTCTCTTTGTGTCTATTTCTGCTTATCAATTAGTGATTACGTATTGAGCACCTAGCACGTGCTTGACGCTGAGCTGAGCCCTTTTTCTCCGCTACTTCCCTAACCATTCCTCTCATTTCTCCATCATACTGCCCATGATGAGTCGGGGACCCAAATGACTCCCAACTGCAATGTCTCCCTGTCCCAAAAAGACCCCCAAACTCTCACCTGCTCCCCAATTGAAGTGTGGATTCCCTCAGGGAAGCTGTCCACATCTGGCTGCAGGGCACAGGCTTCTAGTACTCTCTCCAGCCAGGGTGGGCCCAGCTCCTGCCCGAAGCACACATTCTCTACCACAGAGGTGTTCTGCACCCAGGCCTCCTGGGGCACGTAGGCCACAGCACCCTAAAACACAACTTACTTTGGTCACAGGAGGATGATGGGGACAGAGGTGGGATAGGTTTTGAGGAGCAGTGGGAGCTGGGCTCTCAGTGGTGGGTGAGAGGTGGAGAGAATGAGTGAAAGTGAACTTGGCTGGGATGGGGAGGGTGGGAAGGCAGCGAGGAAGTGGGACTTTCAGGATGGGGACATCCTAGCAGACAGGCTGGGGGTGGCCTCACCTCGATGCTCACGAACCCCTCCACCTTTGACAGCTCCCCAAGGAGGGCGGACAGCAGGGAGGACTTCCCTGCCCCCACTGGACCGACAACAGCCAGCAGACAGCCCTGGGGCACCGTGAGGTTTATTCTGGACACGCAAGAGGGGAGACATGACCTTGGTTAGGGTTCAGCCCGCCTCTGTGAGGAAGGATGAGCCCCAGACGGAGCTGAGCTTTCCTGCTCTGGGAGTCTCCAAGAGGACCTGTGGGGCTGTTCTTTTTCCCAGTCCTTGTCTAGCTATTTGAGGAACTATCCTGTGCACATCTGTGCATGTACACATGCACACAAAGCGTGCACACATGCATGCACATTTGCACACTCATACAAGCATGCTAGCATGCACAGCAACACAATGTGGGCACGCATCCACACACACACAAGTGCATGCACATACCCAATCAATCCATGCTCACACGCATACATGTGTGCACACATGCACACCACGCACACACACACAGGGTTGACTATAGCCTGAGGGTTTCACCAGCCTGGCCTCCTGCCTTGGCTCTTGCGATAAATAGGCTCTTTCCTCCCTCCCTCCCGCTACTCTTGGTCCCGCCCCACTCCTGTCCACGTCCCACAGCCCATCCTCCACCCAGTGACCAGAGGGATCTGTTAAAACCCAAGTCAGATCGTGACACTTCCCAGCTAAACCCGCCAGCACTCCCATTTCACTCAGGGTCAAAGCTAAAGTCCTGACGATCAGGAATGACATCTCCCGCCTCCTTCCGCTCTGTGCCTCAGCTGCTCGGCCCTGGCCTTGCTGACCTCCTTGCTGTTTCTTGAACACAAAAGGCCAGTGGTTCTCACCAGGGGGTGACTGCATCCCCCAGGAGTCATTTGGCAAGATCTAGAGATATTTTTGGATGTCACAACCAGTAGGGGGTGCTGCTGGCATCTAGTGGGTAGAGACTGGGGTCAGCTAAACATCCCACAATGCACACGACAGCCCCCAACAAAGGAGTTTCAGCCCAAAATATCAACCGTGCTGAGGTTGAGAAACCCAGGTCCAGGCACTCTCCTGCCCCAGGACCTTTGCTGATGCCATTCCCACCGCCTAGAAGGTTCTTCTCCCAGGCCGGGCACGGTGGCTCATGCCTGTAATCCTAGTCCTTTGGGAACTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGACGAACATGGTAAAACCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCATGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGAAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCCGCGTGATAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAACAGCTCTTCTCCCAGACACTCCTTCCTTATGATCTCGGCTTGAATGCAAAGCCTTCCCTCGCTAGACATGCCATCGTACTCTGTTCCCTTGCTCTGGTTTTCTGTTTGGGCCTCACCTCTATCAGCATGTCACCCCACGAGAGCAGGGCCCTTGTCTGTTTCCTTCGCCCTATCCCCAATACCTAGAACAGAGCGTGGCCCATACCTAGTGCTCTATCGATGAAGTGAGTGAATGACAACCAATACAAATACTACCTGGGGCATATTCCTTCTCTTCTTAGGGAGTTTCAGGGCTGTCTGAGATTTTTGGCCACAAAGACCAA
Task1_train_22422
This alteration occurs within gene ABCC6 (ATP binding cassette subfamily C member 6) located on Chromosome 16. Is it associated with a disease or is it a benign variant?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
AGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCAGGTGGAAAGTGCTATGAAGAATAAATAGTAAAGCAGGGGGAGCCAGGTTCAGGGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGCTGGGTGGATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAAAAAAAATTAGCCAGTTGTGGTGGTACATGGCTGTAATTCTAGCTACTCATGAGGCTGAGGTGGGAGGATTGCTTGAACTACTCATGAGGCTGAGGTGGGAGGAATGCTTGAACTCAGGAGGTGGAGGTTACAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGCAGGTGCAGGTGTAGGGTGCACTAACAATAGTAGGGTGGCTGTGGTGGTAGATAAGGTGGTCAGGAAAGGCCTCTCTGTGAAGGTGATAGAAGTGAGGGATGAGCCCTGGGGACTCCTGGGGAGAGCTTTCCAGCAGAGGGAACAGCAGTGCAAAGGCCCTGGGGCCAGAGTGTGCTGTGGGGGATCAGGGAATATCACAGAGACTAAGGTGGCTGCAGTAAAGCTGAGAGGTGATGATGGGAGATGGGGCTAATGGATACCAGAGCCAGGTCACAGGGACCTTGCCAGGGATTGTCATGACTTGGGCTTTGTCTCTGAGGTAAATGGGGAGATCACCTGAGGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCCAGGTATGGTGGCATGTGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGTGTGAGAATTGCTTGAACGTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCATCACTGCATGCCAGCCTGTGCAACAGAGCAAGACTCTGTCTCCAAAACAAAACAAAAAACAAAACCACAAGTGGTGGGCTGGATTTGGCTTGGGGTCACAGTTTGCCAACCCCTGCCCAATCCATAGCTCCAGATGCATATATCCTGTTTCTTGGACATCTCTGTCCAGACCCCTTGGTGAGGCCCAGAGAGGGGAAGCAATTACACCAACATTACTCAGCAAGGCAGGGCAGAGTAAGACAGGAGTCTAGGTCTTCTCACTCTCAGTTGTCAGAGAGCTCCTCACTGCCAATCCCTGCCACAACTCCCTGCCTCTCTCTTTGTGTCTATTTCTGCTTATCAATTAGTGATTACGTATTGAGCACCTAGCACGTGCTTGACGCTGAGCTGAGCCCTTTTTCTCCGCTACTTCCCTAACCATTCCTCTCATTTCTCCATCATACTGCCCATGATGAGTCGGGGACCCAAATGACTCCCAACTGCAATGTCTCCCTGTCCCAAAAAGACCCCCAAACTCTCACCTGCTCCCCAATTGAAGTGTGGATTCCCTCAGGGAAGCTGTCCACATCTGGCTGCAGGGCACAGGCTTCTAGTACTCTCTCCAGCCAGGGTGGGTCCAGCTCCTGCCCGAAGCACACATTCTCTACCACAGAGGTGTTCTGCACCCAGGCCTCCTGGGGCACGTAGGCCACAGCACCCTAAAACACAACTTACTTTGGTCACAGGAGGATGATGGGGACAGAGGTGGGATAGGTTTTGAGGAGCAGTGGGAGCTGGGCTCTCAGTGGTGGGTGAGAGGTGGAGAGAATGAGTGAAAGTGAACTTGGCTGGGATGGGGAGGGTGGGAAGGCAGCGAGGAAGTGGGACTTTCAGGATGGGGACATCCTAGCAGACAGGCTGGGGGTGGCCTCACCTCGATGCTCACGAACCCCTCCACCTTTGACAGCTCCCCAAGGAGGGCGGACAGCAGGGAGGACTTCCCTGCCCCCACTGGACCGACAACAGCCAGCAGACAGCCCTGGGGCACCGTGAGGTTTATTCTGGACACGCAAGAGGGGAGACATGACCTTGGTTAGGGTTCAGCCCGCCTCTGTGAGGAAGGATGAGCCCCAGACGGAGCTGAGCTTTCCTGCTCTGGGAGTCTCCAAGAGGACCTGTGGGGCTGTTCTTTTTCCCAGTCCTTGTCTAGCTATTTGAGGAACTATCCTGTGCACATCTGTGCATGTACACATGCACACAAAGCGTGCACACATGCATGCACATTTGCACACTCATACAAGCATGCTAGCATGCACAGCAACACAATGTGGGCACGCATCCACACACACACAAGTGCATGCACATACCCAATCAATCCATGCTCACACGCATACATGTGTGCACACATGCACACCACGCACACACACACAGGGTTGACTATAGCCTGAGGGTTTCACCAGCCTGGCCTCCTGCCTTGGCTCTTGCGATAAATAGGCTCTTTCCTCCCTCCCTCCCGCTACTCTTGGTCCCGCCCCACTCCTGTCCACGTCCCACAGCCCATCCTCCACCCAGTGACCAGAGGGATCTGTTAAAACCCAAGTCAGATCGTGACACTTCCCAGCTAAACCCGCCAGCACTCCCATTTCACTCAGGGTCAAAGCTAAAGTCCTGACGATCAGGAATGACATCTCCCGCCTCCTTCCGCTCTGTGCCTCAGCTGCTCGGCCCTGGCCTTGCTGACCTCCTTGCTGTTTCTTGAACACAAAAGGCCAGTGGTTCTCACCAGGGGGTGACTGCATCCCCCAGGAGTCATTTGGCAAGATCTAGAGATATTTTTGGATGTCACAACCAGTAGGGGGTGCTGCTGGCATCTAGTGGGTAGAGACTGGGGTCAGCTAAACATCCCACAATGCACACGACAGCCCCCAACAAAGGAGTTTCAGCCCAAAATATCAACCGTGCTGAGGTTGAGAAACCCAGGTCCAGGCACTCTCCTGCCCCAGGACCTTTGCTGATGCCATTCCCACCGCCTAGAAGGTTCTTCTCCCAGGCCGGGCACGGTGGCTCATGCCTGTAATCCTAGTCCTTTGGGAACTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGACGAACATGGTAAAACCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCATGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGAAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCCGCGTGATAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAACAGCTCTTCTCCCAGACACTCCTTCCTTATGATCTCGGCTTGAATGCAAAGCCTTCCCTCGCTAGACATGCCATCGTACTCTGTTCCCTTGCTCTGGTTTTCTGTTTGGGCCTCACCTCTATCAGCATGTCACCCCACGAGAGCAGGGCCCTTGTCTGTTTCCTTCGCCCTATCCCCAATACCTAGAACAGAGCGTGGCCCATACCTAGTGCTCTATCGATGAAGTGAGTGAATGACAACCAATACAAATACTACCTGGGGCATATTCCTTCTCTTCTTAGGGAGTTTCAGGGCTGTCTGAGATTTTTGGCCACAAAGACCAAGCGATAGAGTTGGAGACTATAGATGATCATGACCTCGGACTGATACAGGAGGCACAGAAG
AGTTCCACTCTGACACCCAGGCTGGAGTGCAATGGCTTGATCTCGGCTCACTGCAACCTCTGCCTACTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGCAACCCTCCCGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTACCCAGCCATTCATTCATTCTTACATTCAGTCATTCCACTAATAACCACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCAGGTGGAAAGTGCTATGAAGAATAAATAGTAAAGCAGGGGGAGCCAGGTTCAGGGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGCTGGGTGGATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAAAAAAAATTAGCCAGTTGTGGTGGTACATGGCTGTAATTCTAGCTACTCATGAGGCTGAGGTGGGAGGATTGCTTGAACTACTCATGAGGCTGAGGTGGGAGGAATGCTTGAACTCAGGAGGTGGAGGTTACAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGCAGGTGCAGGTGTAGGGTGCACTAACAATAGTAGGGTGGCTGTGGTGGTAGATAAGGTGGTCAGGAAAGGCCTCTCTGTGAAGGTGATAGAAGTGAGGGATGAGCCCTGGGGACTCCTGGGGAGAGCTTTCCAGCAGAGGGAACAGCAGTGCAAAGGCCCTGGGGCCAGAGTGTGCTGTGGGGGATCAGGGAATATCACAGAGACTAAGGTGGCTGCAGTAAAGCTGAGAGGTGATGATGGGAGATGGGGCTAATGGATACCAGAGCCAGGTCACAGGGACCTTGCCAGGGATTGTCATGACTTGGGCTTTGTCTCTGAGGTAAATGGGGAGATCACCTGAGGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCCAGGTATGGTGGCATGTGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGTGTGAGAATTGCTTGAACGTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCATCACTGCATGCCAGCCTGTGCAACAGAGCAAGACTCTGTCTCCAAAACAAAACAAAAAACAAAACCACAAGTGGTGGGCTGGATTTGGCTTGGGGTCACAGTTTGCCAACCCCTGCCCAATCCATAGCTCCAGATGCATATATCCTGTTTCTTGGACATCTCTGTCCAGACCCCTTGGTGAGGCCCAGAGAGGGGAAGCAATTACACCAACATTACTCAGCAAGGCAGGGCAGAGTAAGACAGGAGTCTAGGTCTTCTCACTCTCAGTTGTCAGAGAGCTCCTCACTGCCAATCCCTGCCACAACTCCCTGCCTCTCTCTTTGTGTCTATTTCTGCTTATCAATTAGTGATTACGTATTGAGCACCTAGCACGTGCTTGACGCTGAGCTGAGCCCTTTTTCTCCGCTACTTCCCTAACCATTCCTCTCATTTCTCCATCATACTGCCCATGATGAGTCGGGGACCCAAATGACTCCCAACTGCAATGTCTCCCTGTCCCAAAAAGACCCCCAAACTCTCACCTGCTCCCCAATTGAAGTGTGGATTCCCTCAGGGAAGCTGTCCACATCTGGCTGCAGGGCACAGGCTTCTAGTACTCTCTCCAGCCAGGGTGGGTCCAGCTCCTGCCCGAAGCACACATTCTCTACCACAGAGGTGTTCTGCACCCAGGCCTCCGGGGGCACGTAGGCCACAGCACCCTAAAACACAACTTACTTTGGTCACAGGAGGATGATGGGGACAGAGGTGGGATAGGTTTTGAGGAGCAGTGGGAGCTGGGCTCTCAGTGGTGGGTGAGAGGTGGAGAGAATGAGTGAAAGTGAACTTGGCTGGGATGGGGAGGGTGGGAAGGCAGCGAGGAAGTGGGACTTTCAGGATGGGGACATCCTAGCAGACAGGCTGGGGGTGGCCTCACCTCGATGCTCACGAACCCCTCCACCTTTGACAGCTCCCCAAGGAGGGCGGACAGCAGGGAGGACTTCCCTGCCCCCACTGGACCGACAACAGCCAGCAGACAGCCCTGGGGCACCGTGAGGTTTATTCTGGACACGCAAGAGGGGAGACATGACCTTGGTTAGGGTTCAGCCCGCCTCTGTGAGGAAGGATGAGCCCCAGACGGAGCTGAGCTTTCCTGCTCTGGGAGTCTCCAAGAGGACCTGTGGGGCTGTTCTTTTTCCCAGTCCTTGTCTAGCTATTTGAGGAACTATCCTGTGCACATCTGTGCATGTACACATGCACACAAAGCGTGCACACATGCATGCACATTTGCACACTCATACAAGCATGCTAGCATGCACAGCAACACAATGTGGGCACGCATCCACACACACACAAGTGCATGCACATACCCAATCAATCCATGCTCACACGCATACATGTGTGCACACATGCACACCACGCACACACACACAGGGTTGACTATAGCCTGAGGGTTTCACCAGCCTGGCCTCCTGCCTTGGCTCTTGCGATAAATAGGCTCTTTCCTCCCTCCCTCCCGCTACTCTTGGTCCCGCCCCACTCCTGTCCACGTCCCACAGCCCATCCTCCACCCAGTGACCAGAGGGATCTGTTAAAACCCAAGTCAGATCGTGACACTTCCCAGCTAAACCCGCCAGCACTCCCATTTCACTCAGGGTCAAAGCTAAAGTCCTGACGATCAGGAATGACATCTCCCGCCTCCTTCCGCTCTGTGCCTCAGCTGCTCGGCCCTGGCCTTGCTGACCTCCTTGCTGTTTCTTGAACACAAAAGGCCAGTGGTTCTCACCAGGGGGTGACTGCATCCCCCAGGAGTCATTTGGCAAGATCTAGAGATATTTTTGGATGTCACAACCAGTAGGGGGTGCTGCTGGCATCTAGTGGGTAGAGACTGGGGTCAGCTAAACATCCCACAATGCACACGACAGCCCCCAACAAAGGAGTTTCAGCCCAAAATATCAACCGTGCTGAGGTTGAGAAACCCAGGTCCAGGCACTCTCCTGCCCCAGGACCTTTGCTGATGCCATTCCCACCGCCTAGAAGGTTCTTCTCCCAGGCCGGGCACGGTGGCTCATGCCTGTAATCCTAGTCCTTTGGGAACTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGACGAACATGGTAAAACCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCATGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGAAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCCGCGTGATAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAACAGCTCTTCTCCCAGACACTCCTTCCTTATGATCTCGGCTTGAATGCAAAGCCTTCCCTCGCTAGACATGCCATCGTACTCTGTTCCCTTGCTCTGGTTTTCTGTTTGGGCCTCACCTCTATCAGCATGTCACCCCACGAGAGCAGGGCCCTTGTCTGTTTCCTTCGCCCTATCCCCAATACCTAGAACAGAGCGTGGCCCATACCTAGTGCTCTATCGATGAAGTGAGTGAATGACAACCAATACAAATACTACCTGGGGCATATTCCTTCTCTTCTTAGGGAGTTTCAGGGCTGTCTGAGATTTTTGGCCACAAAGACCAAGCGATAGAGTTGGAGACTATAGATGATCATGACCTCGGACTGATACAGGAGGCACAGAAG
Task1_train_22423
This mutation occurs in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
ACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCAGGTGGAAAGTGCTATGAAGAATAAATAGTAAAGCAGGGGGAGCCAGGTTCAGGGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGCTGGGTGGATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAAAAAAAATTAGCCAGTTGTGGTGGTACATGGCTGTAATTCTAGCTACTCATGAGGCTGAGGTGGGAGGATTGCTTGAACTACTCATGAGGCTGAGGTGGGAGGAATGCTTGAACTCAGGAGGTGGAGGTTACAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGCAGGTGCAGGTGTAGGGTGCACTAACAATAGTAGGGTGGCTGTGGTGGTAGATAAGGTGGTCAGGAAAGGCCTCTCTGTGAAGGTGATAGAAGTGAGGGATGAGCCCTGGGGACTCCTGGGGAGAGCTTTCCAGCAGAGGGAACAGCAGTGCAAAGGCCCTGGGGCCAGAGTGTGCTGTGGGGGATCAGGGAATATCACAGAGACTAAGGTGGCTGCAGTAAAGCTGAGAGGTGATGATGGGAGATGGGGCTAATGGATACCAGAGCCAGGTCACAGGGACCTTGCCAGGGATTGTCATGACTTGGGCTTTGTCTCTGAGGTAAATGGGGAGATCACCTGAGGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCCAGGTATGGTGGCATGTGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGTGTGAGAATTGCTTGAACGTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCATCACTGCATGCCAGCCTGTGCAACAGAGCAAGACTCTGTCTCCAAAACAAAACAAAAAACAAAACCACAAGTGGTGGGCTGGATTTGGCTTGGGGTCACAGTTTGCCAACCCCTGCCCAATCCATAGCTCCAGATGCATATATCCTGTTTCTTGGACATCTCTGTCCAGACCCCTTGGTGAGGCCCAGAGAGGGGAAGCAATTACACCAACATTACTCAGCAAGGCAGGGCAGAGTAAGACAGGAGTCTAGGTCTTCTCACTCTCAGTTGTCAGAGAGCTCCTCACTGCCAATCCCTGCCACAACTCCCTGCCTCTCTCTTTGTGTCTATTTCTGCTTATCAATTAGTGATTACGTATTGAGCACCTAGCACGTGCTTGACGCTGAGCTGAGCCCTTTTTCTCCGCTACTTCCCTAACCATTCCTCTCATTTCTCCATCATACTGCCCATGATGAGTCGGGGACCCAAATGACTCCCAACTGCAATGTCTCCCTGTCCCAAAAAGACCCCCAAACTCTCACCTGCTCCCCAATTGAAGTGTGGATTCCCTCAGGGAAGCTGTCCACATCTGGCTGCAGGGCACAGGCTTCTAGTACTCTCTCCAGCCAGGGTGGGTCCAGCTCCTGCCCGAAGCACACATTCTCTACCACAGAGGTGTTCTGCACCCAGGCCTCCTGGGGCACGTAGGCCACAGCACCCTAAAACACAACTTACTTTGGTCACAGGAGGATGATGGGGACAGAGGTGGGATAGGTTTTGAGGAGCAGTGGGAGCTGGGCTCTCAGTGGTGGGTGAGAGGTGGAGAGAATGAGTGAAAGTGAACTTGGCTGGGATGGGGAGGGTGGGAAGGCAGCGAGGAAGTGGGACTTTCAGGATGGGGACATCCTAGCAGACAGGCTGGGGGTGGCCTCACCTCGATGCTCACGAACCCCTCCACCTTTGACAGCTCCCCAAGGAGGGCGGACAGCAGGGAGGACTTCCCTGCCCCCACTGGACCGACAACAGCCAGCAGACAGCCCTGGGGCACCGTGAGGTTTATTCTGGACACGCAAGAGGGGAGACATGACCTTGGTTAGGGTTCAGCCCGCCTCTGTGAGGAAGGATGAGCCCCAGACGGAGCTGAGCTTTCCTGCTCTGGGAGTCTCCAAGAGGACCTGTGGGGCTGTTCTTTTTCCCAGTCCTTGTCTAGCTATTTGAGGAACTATCCTGTGCACATCTGTGCATGTACACATGCACACAAAGCGTGCACACATGCATGCACATTTGCACACTCATACAAGCATGCTAGCATGCACAGCAACACAATGTGGGCACGCATCCACACACACACAAGTGCATGCACATACCCAATCAATCCATGCTCACACGCATACATGTGTGCACACATGCACACCACGCACACACACACAGGGTTGACTATAGCCTGAGGGTTTCACCAGCCTGGCCTCCTGCCTTGGCTCTTGCGATAAATAGGCTCTTTCCTCCCTCCCTCCCGCTACTCTTGGTCCCGCCCCACTCCTGTCCACGTCCCACAGCCCATCCTCCACCCAGTGACCAGAGGGATCTGTTAAAACCCAAGTCAGATCGTGACACTTCCCAGCTAAACCCGCCAGCACTCCCATTTCACTCAGGGTCAAAGCTAAAGTCCTGACGATCAGGAATGACATCTCCCGCCTCCTTCCGCTCTGTGCCTCAGCTGCTCGGCCCTGGCCTTGCTGACCTCCTTGCTGTTTCTTGAACACAAAAGGCCAGTGGTTCTCACCAGGGGGTGACTGCATCCCCCAGGAGTCATTTGGCAAGATCTAGAGATATTTTTGGATGTCACAACCAGTAGGGGGTGCTGCTGGCATCTAGTGGGTAGAGACTGGGGTCAGCTAAACATCCCACAATGCACACGACAGCCCCCAACAAAGGAGTTTCAGCCCAAAATATCAACCGTGCTGAGGTTGAGAAACCCAGGTCCAGGCACTCTCCTGCCCCAGGACCTTTGCTGATGCCATTCCCACCGCCTAGAAGGTTCTTCTCCCAGGCCGGGCACGGTGGCTCATGCCTGTAATCCTAGTCCTTTGGGAACTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGACGAACATGGTAAAACCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCATGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGAAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCCGCGTGATAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAACAGCTCTTCTCCCAGACACTCCTTCCTTATGATCTCGGCTTGAATGCAAAGCCTTCCCTCGCTAGACATGCCATCGTACTCTGTTCCCTTGCTCTGGTTTTCTGTTTGGGCCTCACCTCTATCAGCATGTCACCCCACGAGAGCAGGGCCCTTGTCTGTTTCCTTCGCCCTATCCCCAATACCTAGAACAGAGCGTGGCCCATACCTAGTGCTCTATCGATGAAGTGAGTGAATGACAACCAATACAAATACTACCTGGGGCATATTCCTTCTCTTCTTAGGGAGTTTCAGGGCTGTCTGAGATTTTTGGCCACAAAGACCAAGCGATAGAGTTGGAGACTATAGATGATCATGACCTCGGACTGATACAGGAGGCACAGAAGTGAGCACAGCTGATAGGGCTGAACCTTGGGGCTCCTCTCAGCCAGCCCTCCCTTGGCATCGTCTTGGCCAGCCTGGGAGCACAGGGGTGTCTCCCCCTAATGGGGGAGGCTCAGATGCCCTGGTCCCCGTCTGCAGGAGATACTGGTCTATGCTGTGCAGGTCCCCACCTTCAGGAGGTAGAGATGTATCCTGAGAACCTCCCCGGCAGAGCCCCAGCCCAGCCAAACCCACCCTCCAGTCCCAGGCTGGAAACCTACACCACCTCTCAGGTGGGAGGCAGCAGGAGCCCCATGCATCTTCTCCCTAAAAAC
ACTGCCTCGTTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCAGGTGGAAAGTGCTATGAAGAATAAATAGTAAAGCAGGGGGAGCCAGGTTCAGGGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGCTGGGTGGATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAAAAAAAATTAGCCAGTTGTGGTGGTACATGGCTGTAATTCTAGCTACTCATGAGGCTGAGGTGGGAGGATTGCTTGAACTACTCATGAGGCTGAGGTGGGAGGAATGCTTGAACTCAGGAGGTGGAGGTTACAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGCAGGTGCAGGTGTAGGGTGCACTAACAATAGTAGGGTGGCTGTGGTGGTAGATAAGGTGGTCAGGAAAGGCCTCTCTGTGAAGGTGATAGAAGTGAGGGATGAGCCCTGGGGACTCCTGGGGAGAGCTTTCCAGCAGAGGGAACAGCAGTGCAAAGGCCCTGGGGCCAGAGTGTGCTGTGGGGGATCAGGGAATATCACAGAGACTAAGGTGGCTGCAGTAAAGCTGAGAGGTGATGATGGGAGATGGGGCTAATGGATACCAGAGCCAGGTCACAGGGACCTTGCCAGGGATTGTCATGACTTGGGCTTTGTCTCTGAGGTAAATGGGGAGATCACCTGAGGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCCAGGTATGGTGGCATGTGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGTGTGAGAATTGCTTGAACGTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCATCACTGCATGCCAGCCTGTGCAACAGAGCAAGACTCTGTCTCCAAAACAAAACAAAAAACAAAACCACAAGTGGTGGGCTGGATTTGGCTTGGGGTCACAGTTTGCCAACCCCTGCCCAATCCATAGCTCCAGATGCATATATCCTGTTTCTTGGACATCTCTGTCCAGACCCCTTGGTGAGGCCCAGAGAGGGGAAGCAATTACACCAACATTACTCAGCAAGGCAGGGCAGAGTAAGACAGGAGTCTAGGTCTTCTCACTCTCAGTTGTCAGAGAGCTCCTCACTGCCAATCCCTGCCACAACTCCCTGCCTCTCTCTTTGTGTCTATTTCTGCTTATCAATTAGTGATTACGTATTGAGCACCTAGCACGTGCTTGACGCTGAGCTGAGCCCTTTTTCTCCGCTACTTCCCTAACCATTCCTCTCATTTCTCCATCATACTGCCCATGATGAGTCGGGGACCCAAATGACTCCCAACTGCAATGTCTCCCTGTCCCAAAAAGACCCCCAAACTCTCACCTGCTCCCCAATTGAAGTGTGGATTCCCTCAGGGAAGCTGTCCACATCTGGCTGCAGGGCACAGGCTTCTAGTACTCTCTCCAGCCAGGGTGGGTCCAGCTCCTGCCCGAAGCACACATTCTCTACCACAGAGGTGTTCTGCACCCAGGCCTCCTGGGGCACGTAGGCCACAGCACCCTAAAACACAACTTACTTTGGTCACAGGAGGATGATGGGGACAGAGGTGGGATAGGTTTTGAGGAGCAGTGGGAGCTGGGCTCTCAGTGGTGGGTGAGAGGTGGAGAGAATGAGTGAAAGTGAACTTGGCTGGGATGGGGAGGGTGGGAAGGCAGCGAGGAAGTGGGACTTTCAGGATGGGGACATCCTAGCAGACAGGCTGGGGGTGGCCTCACCTCGATGCTCACGAACCCCTCCACCTTTGACAGCTCCCCAAGGAGGGCGGACAGCAGGGAGGACTTCCCTGCCCACACTGGACCGACAACAGCCAGCAGACAGCCCTGGGGCACCGTGAGGTTTATTCTGGACACGCAAGAGGGGAGACATGACCTTGGTTAGGGTTCAGCCCGCCTCTGTGAGGAAGGATGAGCCCCAGACGGAGCTGAGCTTTCCTGCTCTGGGAGTCTCCAAGAGGACCTGTGGGGCTGTTCTTTTTCCCAGTCCTTGTCTAGCTATTTGAGGAACTATCCTGTGCACATCTGTGCATGTACACATGCACACAAAGCGTGCACACATGCATGCACATTTGCACACTCATACAAGCATGCTAGCATGCACAGCAACACAATGTGGGCACGCATCCACACACACACAAGTGCATGCACATACCCAATCAATCCATGCTCACACGCATACATGTGTGCACACATGCACACCACGCACACACACACAGGGTTGACTATAGCCTGAGGGTTTCACCAGCCTGGCCTCCTGCCTTGGCTCTTGCGATAAATAGGCTCTTTCCTCCCTCCCTCCCGCTACTCTTGGTCCCGCCCCACTCCTGTCCACGTCCCACAGCCCATCCTCCACCCAGTGACCAGAGGGATCTGTTAAAACCCAAGTCAGATCGTGACACTTCCCAGCTAAACCCGCCAGCACTCCCATTTCACTCAGGGTCAAAGCTAAAGTCCTGACGATCAGGAATGACATCTCCCGCCTCCTTCCGCTCTGTGCCTCAGCTGCTCGGCCCTGGCCTTGCTGACCTCCTTGCTGTTTCTTGAACACAAAAGGCCAGTGGTTCTCACCAGGGGGTGACTGCATCCCCCAGGAGTCATTTGGCAAGATCTAGAGATATTTTTGGATGTCACAACCAGTAGGGGGTGCTGCTGGCATCTAGTGGGTAGAGACTGGGGTCAGCTAAACATCCCACAATGCACACGACAGCCCCCAACAAAGGAGTTTCAGCCCAAAATATCAACCGTGCTGAGGTTGAGAAACCCAGGTCCAGGCACTCTCCTGCCCCAGGACCTTTGCTGATGCCATTCCCACCGCCTAGAAGGTTCTTCTCCCAGGCCGGGCACGGTGGCTCATGCCTGTAATCCTAGTCCTTTGGGAACTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGACGAACATGGTAAAACCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCATGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGAAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCCGCGTGATAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAACAGCTCTTCTCCCAGACACTCCTTCCTTATGATCTCGGCTTGAATGCAAAGCCTTCCCTCGCTAGACATGCCATCGTACTCTGTTCCCTTGCTCTGGTTTTCTGTTTGGGCCTCACCTCTATCAGCATGTCACCCCACGAGAGCAGGGCCCTTGTCTGTTTCCTTCGCCCTATCCCCAATACCTAGAACAGAGCGTGGCCCATACCTAGTGCTCTATCGATGAAGTGAGTGAATGACAACCAATACAAATACTACCTGGGGCATATTCCTTCTCTTCTTAGGGAGTTTCAGGGCTGTCTGAGATTTTTGGCCACAAAGACCAAGCGATAGAGTTGGAGACTATAGATGATCATGACCTCGGACTGATACAGGAGGCACAGAAGTGAGCACAGCTGATAGGGCTGAACCTTGGGGCTCCTCTCAGCCAGCCCTCCCTTGGCATCGTCTTGGCCAGCCTGGGAGCACAGGGGTGTCTCCCCCTAATGGGGGAGGCTCAGATGCCCTGGTCCCCGTCTGCAGGAGATACTGGTCTATGCTGTGCAGGTCCCCACCTTCAGGAGGTAGAGATGTATCCTGAGAACCTCCCCGGCAGAGCCCCAGCCCAGCCAAACCCACCCTCCAGTCCCAGGCTGGAAACCTACACCACCTCTCAGGTGGGAGGCAGCAGGAGCCCCATGCATCTTCTCCCTAAAAAC
Task1_train_22424
This gene mutation involves ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Is it associated with any clinical condition, or is it benign?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
TTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCAGGTGGAAAGTGCTATGAAGAATAAATAGTAAAGCAGGGGGAGCCAGGTTCAGGGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGCTGGGTGGATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAAAAAAAATTAGCCAGTTGTGGTGGTACATGGCTGTAATTCTAGCTACTCATGAGGCTGAGGTGGGAGGATTGCTTGAACTACTCATGAGGCTGAGGTGGGAGGAATGCTTGAACTCAGGAGGTGGAGGTTACAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGCAGGTGCAGGTGTAGGGTGCACTAACAATAGTAGGGTGGCTGTGGTGGTAGATAAGGTGGTCAGGAAAGGCCTCTCTGTGAAGGTGATAGAAGTGAGGGATGAGCCCTGGGGACTCCTGGGGAGAGCTTTCCAGCAGAGGGAACAGCAGTGCAAAGGCCCTGGGGCCAGAGTGTGCTGTGGGGGATCAGGGAATATCACAGAGACTAAGGTGGCTGCAGTAAAGCTGAGAGGTGATGATGGGAGATGGGGCTAATGGATACCAGAGCCAGGTCACAGGGACCTTGCCAGGGATTGTCATGACTTGGGCTTTGTCTCTGAGGTAAATGGGGAGATCACCTGAGGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCCAGGTATGGTGGCATGTGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGTGTGAGAATTGCTTGAACGTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCATCACTGCATGCCAGCCTGTGCAACAGAGCAAGACTCTGTCTCCAAAACAAAACAAAAAACAAAACCACAAGTGGTGGGCTGGATTTGGCTTGGGGTCACAGTTTGCCAACCCCTGCCCAATCCATAGCTCCAGATGCATATATCCTGTTTCTTGGACATCTCTGTCCAGACCCCTTGGTGAGGCCCAGAGAGGGGAAGCAATTACACCAACATTACTCAGCAAGGCAGGGCAGAGTAAGACAGGAGTCTAGGTCTTCTCACTCTCAGTTGTCAGAGAGCTCCTCACTGCCAATCCCTGCCACAACTCCCTGCCTCTCTCTTTGTGTCTATTTCTGCTTATCAATTAGTGATTACGTATTGAGCACCTAGCACGTGCTTGACGCTGAGCTGAGCCCTTTTTCTCCGCTACTTCCCTAACCATTCCTCTCATTTCTCCATCATACTGCCCATGATGAGTCGGGGACCCAAATGACTCCCAACTGCAATGTCTCCCTGTCCCAAAAAGACCCCCAAACTCTCACCTGCTCCCCAATTGAAGTGTGGATTCCCTCAGGGAAGCTGTCCACATCTGGCTGCAGGGCACAGGCTTCTAGTACTCTCTCCAGCCAGGGTGGGTCCAGCTCCTGCCCGAAGCACACATTCTCTACCACAGAGGTGTTCTGCACCCAGGCCTCCTGGGGCACGTAGGCCACAGCACCCTAAAACACAACTTACTTTGGTCACAGGAGGATGATGGGGACAGAGGTGGGATAGGTTTTGAGGAGCAGTGGGAGCTGGGCTCTCAGTGGTGGGTGAGAGGTGGAGAGAATGAGTGAAAGTGAACTTGGCTGGGATGGGGAGGGTGGGAAGGCAGCGAGGAAGTGGGACTTTCAGGATGGGGACATCCTAGCAGACAGGCTGGGGGTGGCCTCACCTCGATGCTCACGAACCCCTCCACCTTTGACAGCTCCCCAAGGAGGGCGGACAGCAGGGAGGACTTCCCTGCCCCCACTGGACCGACAACAGCCAGCAGACAGCCCTGGGGCACCGTGAGGTTTATTCTGGACACGCAAGAGGGGAGACATGACCTTGGTTAGGGTTCAGCCCGCCTCTGTGAGGAAGGATGAGCCCCAGACGGAGCTGAGCTTTCCTGCTCTGGGAGTCTCCAAGAGGACCTGTGGGGCTGTTCTTTTTCCCAGTCCTTGTCTAGCTATTTGAGGAACTATCCTGTGCACATCTGTGCATGTACACATGCACACAAAGCGTGCACACATGCATGCACATTTGCACACTCATACAAGCATGCTAGCATGCACAGCAACACAATGTGGGCACGCATCCACACACACACAAGTGCATGCACATACCCAATCAATCCATGCTCACACGCATACATGTGTGCACACATGCACACCACGCACACACACACAGGGTTGACTATAGCCTGAGGGTTTCACCAGCCTGGCCTCCTGCCTTGGCTCTTGCGATAAATAGGCTCTTTCCTCCCTCCCTCCCGCTACTCTTGGTCCCGCCCCACTCCTGTCCACGTCCCACAGCCCATCCTCCACCCAGTGACCAGAGGGATCTGTTAAAACCCAAGTCAGATCGTGACACTTCCCAGCTAAACCCGCCAGCACTCCCATTTCACTCAGGGTCAAAGCTAAAGTCCTGACGATCAGGAATGACATCTCCCGCCTCCTTCCGCTCTGTGCCTCAGCTGCTCGGCCCTGGCCTTGCTGACCTCCTTGCTGTTTCTTGAACACAAAAGGCCAGTGGTTCTCACCAGGGGGTGACTGCATCCCCCAGGAGTCATTTGGCAAGATCTAGAGATATTTTTGGATGTCACAACCAGTAGGGGGTGCTGCTGGCATCTAGTGGGTAGAGACTGGGGTCAGCTAAACATCCCACAATGCACACGACAGCCCCCAACAAAGGAGTTTCAGCCCAAAATATCAACCGTGCTGAGGTTGAGAAACCCAGGTCCAGGCACTCTCCTGCCCCAGGACCTTTGCTGATGCCATTCCCACCGCCTAGAAGGTTCTTCTCCCAGGCCGGGCACGGTGGCTCATGCCTGTAATCCTAGTCCTTTGGGAACTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGACGAACATGGTAAAACCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCATGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGAAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCCGCGTGATAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAACAGCTCTTCTCCCAGACACTCCTTCCTTATGATCTCGGCTTGAATGCAAAGCCTTCCCTCGCTAGACATGCCATCGTACTCTGTTCCCTTGCTCTGGTTTTCTGTTTGGGCCTCACCTCTATCAGCATGTCACCCCACGAGAGCAGGGCCCTTGTCTGTTTCCTTCGCCCTATCCCCAATACCTAGAACAGAGCGTGGCCCATACCTAGTGCTCTATCGATGAAGTGAGTGAATGACAACCAATACAAATACTACCTGGGGCATATTCCTTCTCTTCTTAGGGAGTTTCAGGGCTGTCTGAGATTTTTGGCCACAAAGACCAAGCGATAGAGTTGGAGACTATAGATGATCATGACCTCGGACTGATACAGGAGGCACAGAAGTGAGCACAGCTGATAGGGCTGAACCTTGGGGCTCCTCTCAGCCAGCCCTCCCTTGGCATCGTCTTGGCCAGCCTGGGAGCACAGGGGTGTCTCCCCCTAATGGGGGAGGCTCAGATGCCCTGGTCCCCGTCTGCAGGAGATACTGGTCTATGCTGTGCAGGTCCCCACCTTCAGGAGGTAGAGATGTATCCTGAGAACCTCCCCGGCAGAGCCCCAGCCCAGCCAAACCCACCCTCCAGTCCCAGGCTGGAAACCTACACCACCTCTCAGGTGGGAGGCAGCAGGAGCCCCATGCATCTTCTCCCTAAAAACATGAGGCTG
TTATCATAAACCAGGCATGGTTCTAGGCTCTGGAGAAACAGCAATGAGCAAAACAAAGTTGCTGCTCTCTTAATGGATCCATCATTCTCATGAAGGGGACAGAGACAGGCAATCCATAAACAAGTAAGGCAGACAGCACATCAGGTGGAAAGTGCTATGAAGAATAAATAGTAAAGCAGGGGGAGCCAGGTTCAGGGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGAGCTGGGTGGATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAAAAAAAATTAGCCAGTTGTGGTGGTACATGGCTGTAATTCTAGCTACTCATGAGGCTGAGGTGGGAGGATTGCTTGAACTACTCATGAGGCTGAGGTGGGAGGAATGCTTGAACTCAGGAGGTGGAGGTTACAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGCAGGTGCAGGTGTAGGGTGCACTAACAATAGTAGGGTGGCTGTGGTGGTAGATAAGGTGGTCAGGAAAGGCCTCTCTGTGAAGGTGATAGAAGTGAGGGATGAGCCCTGGGGACTCCTGGGGAGAGCTTTCCAGCAGAGGGAACAGCAGTGCAAAGGCCCTGGGGCCAGAGTGTGCTGTGGGGGATCAGGGAATATCACAGAGACTAAGGTGGCTGCAGTAAAGCTGAGAGGTGATGATGGGAGATGGGGCTAATGGATACCAGAGCCAGGTCACAGGGACCTTGCCAGGGATTGTCATGACTTGGGCTTTGTCTCTGAGGTAAATGGGGAGATCACCTGAGGTCCGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATATAAAAATTAGCCAGGTATGGTGGCATGTGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGTGTGAGAATTGCTTGAACGTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCATCACTGCATGCCAGCCTGTGCAACAGAGCAAGACTCTGTCTCCAAAACAAAACAAAAAACAAAACCACAAGTGGTGGGCTGGATTTGGCTTGGGGTCACAGTTTGCCAACCCCTGCCCAATCCATAGCTCCAGATGCATATATCCTGTTTCTTGGACATCTCTGTCCAGACCCCTTGGTGAGGCCCAGAGAGGGGAAGCAATTACACCAACATTACTCAGCAAGGCAGGGCAGAGTAAGACAGGAGTCTAGGTCTTCTCACTCTCAGTTGTCAGAGAGCTCCTCACTGCCAATCCCTGCCACAACTCCCTGCCTCTCTCTTTGTGTCTATTTCTGCTTATCAATTAGTGATTACGTATTGAGCACCTAGCACGTGCTTGACGCTGAGCTGAGCCCTTTTTCTCCGCTACTTCCCTAACCATTCCTCTCATTTCTCCATCATACTGCCCATGATGAGTCGGGGACCCAAATGACTCCCAACTGCAATGTCTCCCTGTCCCAAAAAGACCCCCAAACTCTCACCTGCTCCCCAATTGAAGTGTGGATTCCCTCAGGGAAGCTGTCCACATCTGGCTGCAGGGCACAGGCTTCTAGTACTCTCTCCAGCCAGGGTGGGTCCAGCTCCTGCCCGAAGCACACATTCTCTACCACAGAGGTGTTCTGCACCCAGGCCTCCTGGGGCACGTAGGCCACAGCACCCTAAAACACAACTTACTTTGGTCACAGGAGGATGATGGGGACAGAGGTGGGATAGGTTTTGAGGAGCAGTGGGAGCTGGGCTCTCAGTGGTGGGTGAGAGGTGGAGAGAATGAGTGAAAGTGAACTTGGCTGGGATGGGGAGGGTGGGAAGGCAGCGAGGAAGTGGGACTTTCAGGATGGGGACATCCTAGCAGACAGGCTGGGGGTGGCCTCACCTCGATGCTCACGAACCCCTCCACCTTTGACAGCTCCCCAAGGAGGGCGGACAGCAGGGAGGACTTCCCTGCCCCCACTGGACAGACAACAGCCAGCAGACAGCCCTGGGGCACCGTGAGGTTTATTCTGGACACGCAAGAGGGGAGACATGACCTTGGTTAGGGTTCAGCCCGCCTCTGTGAGGAAGGATGAGCCCCAGACGGAGCTGAGCTTTCCTGCTCTGGGAGTCTCCAAGAGGACCTGTGGGGCTGTTCTTTTTCCCAGTCCTTGTCTAGCTATTTGAGGAACTATCCTGTGCACATCTGTGCATGTACACATGCACACAAAGCGTGCACACATGCATGCACATTTGCACACTCATACAAGCATGCTAGCATGCACAGCAACACAATGTGGGCACGCATCCACACACACACAAGTGCATGCACATACCCAATCAATCCATGCTCACACGCATACATGTGTGCACACATGCACACCACGCACACACACACAGGGTTGACTATAGCCTGAGGGTTTCACCAGCCTGGCCTCCTGCCTTGGCTCTTGCGATAAATAGGCTCTTTCCTCCCTCCCTCCCGCTACTCTTGGTCCCGCCCCACTCCTGTCCACGTCCCACAGCCCATCCTCCACCCAGTGACCAGAGGGATCTGTTAAAACCCAAGTCAGATCGTGACACTTCCCAGCTAAACCCGCCAGCACTCCCATTTCACTCAGGGTCAAAGCTAAAGTCCTGACGATCAGGAATGACATCTCCCGCCTCCTTCCGCTCTGTGCCTCAGCTGCTCGGCCCTGGCCTTGCTGACCTCCTTGCTGTTTCTTGAACACAAAAGGCCAGTGGTTCTCACCAGGGGGTGACTGCATCCCCCAGGAGTCATTTGGCAAGATCTAGAGATATTTTTGGATGTCACAACCAGTAGGGGGTGCTGCTGGCATCTAGTGGGTAGAGACTGGGGTCAGCTAAACATCCCACAATGCACACGACAGCCCCCAACAAAGGAGTTTCAGCCCAAAATATCAACCGTGCTGAGGTTGAGAAACCCAGGTCCAGGCACTCTCCTGCCCCAGGACCTTTGCTGATGCCATTCCCACCGCCTAGAAGGTTCTTCTCCCAGGCCGGGCACGGTGGCTCATGCCTGTAATCCTAGTCCTTTGGGAACTGAGGCAGGTGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGACGAACATGGTAAAACCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCATGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGAAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCCGCGTGATAGAGCAAGACTCCGTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAACAGCTCTTCTCCCAGACACTCCTTCCTTATGATCTCGGCTTGAATGCAAAGCCTTCCCTCGCTAGACATGCCATCGTACTCTGTTCCCTTGCTCTGGTTTTCTGTTTGGGCCTCACCTCTATCAGCATGTCACCCCACGAGAGCAGGGCCCTTGTCTGTTTCCTTCGCCCTATCCCCAATACCTAGAACAGAGCGTGGCCCATACCTAGTGCTCTATCGATGAAGTGAGTGAATGACAACCAATACAAATACTACCTGGGGCATATTCCTTCTCTTCTTAGGGAGTTTCAGGGCTGTCTGAGATTTTTGGCCACAAAGACCAAGCGATAGAGTTGGAGACTATAGATGATCATGACCTCGGACTGATACAGGAGGCACAGAAGTGAGCACAGCTGATAGGGCTGAACCTTGGGGCTCCTCTCAGCCAGCCCTCCCTTGGCATCGTCTTGGCCAGCCTGGGAGCACAGGGGTGTCTCCCCCTAATGGGGGAGGCTCAGATGCCCTGGTCCCCGTCTGCAGGAGATACTGGTCTATGCTGTGCAGGTCCCCACCTTCAGGAGGTAGAGATGTATCCTGAGAACCTCCCCGGCAGAGCCCCAGCCCAGCCAAACCCACCCTCCAGTCCCAGGCTGGAAACCTACACCACCTCTCAGGTGGGAGGCAGCAGGAGCCCCATGCATCTTCTCCCTAAAAACATGAGGCTG
Task1_train_22425
Consider this mutation in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Is this a benign change or a disease-causing variant?
Pathogenic; not provided
GAAGAAATCTCTCCCACTGAACAAATTGCCCTGCTACTCACTGGCTTGTGGGTGACCCCGCAGGGTTCTTGTTCTGTCCGTGTCCCATGGCTACATAATCCAGGGGGAGGCAAACTGTGGCCCAGAGACCAAATCCTGCCTGCTGCCTTTTCTTATAAATAAAGTTTTATTGGAACACGGCCACATCCATTCATTTCTCTATTTCATGCTTTGAGCAGTTGTGACAGAGACTGTGTGGCCCACAGGCCTAAAATATGCACAATCTGGTCATTTATGGAAAAAGTTAGTGAATTTCTGAAATAAATTATCATCAAATCCCAGCCTTCCCAGAGTGAAGGGGGTGTTATTAATTTCACTGTGGCCGGCACAGTGTCTCATGCCTGTAATCCCAGCACTTTAGGAAGCAGAGGTGGTAGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGCCTCTACCAAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCACAGCTACTTGAGAGGCTAAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATTGCACCACTGCACTCCAGCCTGGATGACGGAGTAAGACTGTGTCTCAAAAATACTACTGCTACTACTACTAATTATTATTATTATTTCACTGTGATAACAAGTGTAATTAGATTAGTGGTTCTTGATCCTTAAGACGTAGTTAGAATTGCCTGAAAGATTTTCTAAAAATCAAAGCTCTCATGGCTTAGCCCAGATCAATTAAATTCATCGTCACAATTAGCTGCTATAACGATTAACATGCCCATTTTGGAGATGGGAACACGGAAGCTCAGAGAGATGATCTACTTGTCAGGATCACCCAGCTAGTCAGTGCTGGGGCTGGGATTTGGACCTGGGCAGTTGAATGCCACAGGCTCGGCTTCTTACCACTATGTGGGTGTTTTCCAGGTACACAGTTTGCCCAGGTTCTTCAGTGCAACAAGGGGGAGGGTGTCTTGGCCCGTGGCATAAAAGAAGGATGGGGTGGAGGGGGAAGCCCAGGTAACTTGAGCTTGGTAAGTCTCATCGTGCAATGGTGCTTGAAATGCTGCTATTTTCCAGCTTGATCAAAATGCTGTCATGCTTATTACCTGGGACTTTCTGCATGAGGACAAGGACCTGGTCTGTTAGAGCAGGAGTCCTCAACCCCCAGGCCACAGACTGGTACCAGTCTGCAGCCTCTTAGGAACTGGGCCATACAGCAGGAGGTGAGCGCAGGGCAGGTGAGCAGAGTGTCATCTGTGTTTATAGCCACTCCCCATCACTCCCATCACCGCCTGAGCTCCACCTCCTGCCAAATCAGCAGCAGCAATAGATTCTCAAAGGAGCACGAACACTTGTGAACTGTGCATGTGAGGAATCTGGGTTGCGTGTTCCTTATAAGAATCTAATGCCTGATGATCTCTGTCTCCCATCACCCGCTTTGGGGCCATCTAGTTGACGGAAAGCAAGCTCAGGGCTCCCACTGGTTCTACGTTATGGTGAGTTGTATAATTATTTCATTATATAGTACAATGTAATAATAATAAAGGGCACAATAAATGGAATGTGTTTGAATCATCCCAAAACCACGCGCCTCTCCCCGGTCCGTGGGAAAACTGTCTTCCACAAAACCAGTCCCTGGTGCCAAAAAGCTTGGGGACCACTGTGTTAGAGTGTTCCCTGTTGTACACCCAGGATGGTACAAAGTGGGCGCTCAGTGAGTGGTCGCTGAATGGCTAGCAGAAAGAAGAGCAGCACGGTGCCAGTTTCCAAGTGACACGCAGATGGCGTGATCTGCACGTGTCATCCATTGCCCGCAGCCCCCATCTCCCCCCAGTACTGATGCTGGCTTGCCATTATGGGCTGGGGTGGCCCCCACATCCCCCATCCCTCCCACACCCCTCCTGCCAGACTCAGCACTCACCGCTTCCAGAGGAACTTGAGTCTACGACACCAGGGTCAACTTCTTCCAGGCAGAGGAAGGTGACCAGACGGTCAAAGGACACCCGGGCCTAGGAAAACCGAAGCCGCAGGTCACCCAGCAAGAAGAGCAAAGAACTCAGGTTTTGGGTGTCGGTGTCTCAAGATGTGTGGCAACAGCTTCCTGTCTACCAAGCTCTGTGCATAGGAGGCGTGAGGACAAAGCTTTCTAGTTCATGGGAAACGATGCAACCCGAGTGGTGACCTTGATGGTGGTGATCTCCCACCTCTGCGATCCTACAAATCAGTGACACCGAAGCAAGCCAGCTGCCATTCTGCAGACAAGATCTGGGAAGAGGATGGTGGCTTTTCCAATAAGGTTATCAAGCCATTGTGTGGAACAATTTCAAATGTTGTCCACCTGGGGGCGCTCTCTCCCAGTCACAAACCCATCTTTGGGGAAGAAAGAGACCAGTCGTTAAAATAGAGATTAGGCCAGGTGCAGCGGCTCATGCCGGTAATCCCAGCACTTTGGGAAGCCAAGTGCAGGAGGATCACTTGAGGCCAGGAGTTGGAGACCTGGGGAACATAGCAAGACTCTTTGTTTCTACAAAAAATTAAAAAAATTAGCCGGATGTGGTGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGGGAGGTAGAAGCATCACTTGAGTCCAGGAGTTTGAGCATGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACACTGTCTCAATAAATAAATTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAGGCGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCTTATTACATGAGGTCGGGGGTTCAAGACCAGCCTGGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAACACAATAAATAAATAAATAAGACTGGGTGCAGTGGCTCATGTCTGTAATCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAGCGGTTCAAGACCTGCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAG
GAAGAAATCTCTCCCACTGAACAAATTGCCCTGCTACTCACTGGCTTGTGGGTGACCCCGCAGGGTTCTTGTTCTGTCCGTGTCCCATGGCTACATAATCCAGGGGGAGGCAAACTGTGGCCCAGAGACCAAATCCTGCCTGCTGCCTTTTCTTATAAATAAAGTTTTATTGGAACACGGCCACATCCATTCATTTCTCTATTTCATGCTTTGAGCAGTTGTGACAGAGACTGTGTGGCCCACAGGCCTAAAATATGCACAATCTGGTCATTTATGGAAAAAGTTAGTGAATTTCTGAAATAAATTATCATCAAATCCCAGCCTTCCCAGAGTGAAGGGGGTGTTATTAATTTCACTGTGGCCGGCACAGTGTCTCATGCCTGTAATCCCAGCACTTTAGGAAGCAGAGGTGGTAGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGCCTCTACCAAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCACAGCTACTTGAGAGGCTAAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATTGCACCACTGCACTCCAGCCTGGATGACGGAGTAAGACTGTGTCTCAAAAATACTACTGCTACTACTACTAATTATTATTATTATTTCACTGTGATAACAAGTGTAATTAGATTAGTGGTTCTTGATCCTTAAGACGTAGTTAGAATTGCCTGAAAGATTTTCTAAAAATCAAAGCTCTCATGGCTTAGCCCAGATCAATTAAATTCATCGTCACAATTAGCTGCTATAACGATTAACATGCCCATTTTGGAGATGGGAACACGGAAGCTCAGAGAGATGATCTACTTGTCAGGATCACCCAGCTAGTCAGTGCTGGGGCTGGGATTTGGACCTGGGCAGTTGAATGCCACAGGCTCGGCTTCTTACCACTATGTGGGTGTTTTCCAGGTACACAGTTTGCCCAGGTTCTTCAGTGCAACAAGGGGGAGGGTGTCTTGGCCCGTGGCATAAAAGAAGGATGGGGTGGAGGGGGAAGCCCAGGTAACTTGAGCTTGGTAAGTCTCATCGTGCAATGGTGCTTGAAATGCTGCTATTTTCCAGCTTGATCAAAATGCTGTCATGCTTATTACCTGGGACTTTCTGCATGAGGACAAGGACCTGGTCTGTTAGAGCAGGAGTCCTCAACCCCCAGGCCACAGACTGGTACCAGTCTGCAGCCTCTTAGGAACTGGGCCATACAGCAGGAGGTGAGCGCAGGGCAGGTGAGCAGAGTGTCATCTGTGTTTATAGCCACTCCCCATCACTCCCATCACCGCCTGAGCTCCACCTCCTGCCAAATCAGCAGCAGCAATAGATTCTCAAAGGAGCACGAACACTTGTGAACTGTGCATGTGAGGAATCTGGGTTGCGTGTTCCTTATAAGAATCTAATGCCTGATGATCTCTGTCTCCCATCACCCGCTTTGGGGCCATCTAGTTGACGGAAAGCAAGCTCAGGGCTCCCACTGGTTCTACGTTATGGTGAGTTGTATAATTATTTCATTATATAGTACAATGTAATAATAATAAAGGGCACAATAAATGGAATGTGTTTGAATCATCCCAAAACCACGCGCCTCTCCCCGGTCCGTGGGAAAACTGTCTTCCACAAAACCAGTCCCTGGTGCCAAAAAGCTTGGGGACCACTGTGTTAGAGTGTTCCCTGTTGTACACCCAGGATGGTACAAAGTGGGCGCTCAGTGAGTGGTCGCTGAATGGCTAGCAGAAAGAAGAGCAGCACGGTGCCAGTTTCCAAGTGACACGCAGATGGCGTGATCTGCACGTGTCATCCATTGCCCGCAGCCCCCATCTCCCCCCAGTACTGATGCTGGCTTGCCATTATGGGCTGGGGTGGCCCCCACATCCCCCATCCCTCCCACACCCCTCCTGCCAGACTCAGCACTCACCGCTTCCAGAGGAACTTGAGTCTACGACACCAGGGTCAACTTCTTCCAGGCAGAGGAAGGTGACCAGAGGGTCAAAGGACACCCGGGCCTAGGAAAACCGAAGCCGCAGGTCACCCAGCAAGAAGAGCAAAGAACTCAGGTTTTGGGTGTCGGTGTCTCAAGATGTGTGGCAACAGCTTCCTGTCTACCAAGCTCTGTGCATAGGAGGCGTGAGGACAAAGCTTTCTAGTTCATGGGAAACGATGCAACCCGAGTGGTGACCTTGATGGTGGTGATCTCCCACCTCTGCGATCCTACAAATCAGTGACACCGAAGCAAGCCAGCTGCCATTCTGCAGACAAGATCTGGGAAGAGGATGGTGGCTTTTCCAATAAGGTTATCAAGCCATTGTGTGGAACAATTTCAAATGTTGTCCACCTGGGGGCGCTCTCTCCCAGTCACAAACCCATCTTTGGGGAAGAAAGAGACCAGTCGTTAAAATAGAGATTAGGCCAGGTGCAGCGGCTCATGCCGGTAATCCCAGCACTTTGGGAAGCCAAGTGCAGGAGGATCACTTGAGGCCAGGAGTTGGAGACCTGGGGAACATAGCAAGACTCTTTGTTTCTACAAAAAATTAAAAAAATTAGCCGGATGTGGTGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGGGAGGTAGAAGCATCACTTGAGTCCAGGAGTTTGAGCATGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACACTGTCTCAATAAATAAATTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAGGCGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCTTATTACATGAGGTCGGGGGTTCAAGACCAGCCTGGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAACACAATAAATAAATAAATAAGACTGGGTGCAGTGGCTCATGTCTGTAATCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAGCGGTTCAAGACCTGCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAG
Task1_train_22426
Consider this mutation in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Is this a benign change or a disease-causing variant?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
AAGAAATCTCTCCCACTGAACAAATTGCCCTGCTACTCACTGGCTTGTGGGTGACCCCGCAGGGTTCTTGTTCTGTCCGTGTCCCATGGCTACATAATCCAGGGGGAGGCAAACTGTGGCCCAGAGACCAAATCCTGCCTGCTGCCTTTTCTTATAAATAAAGTTTTATTGGAACACGGCCACATCCATTCATTTCTCTATTTCATGCTTTGAGCAGTTGTGACAGAGACTGTGTGGCCCACAGGCCTAAAATATGCACAATCTGGTCATTTATGGAAAAAGTTAGTGAATTTCTGAAATAAATTATCATCAAATCCCAGCCTTCCCAGAGTGAAGGGGGTGTTATTAATTTCACTGTGGCCGGCACAGTGTCTCATGCCTGTAATCCCAGCACTTTAGGAAGCAGAGGTGGTAGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGCCTCTACCAAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCACAGCTACTTGAGAGGCTAAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATTGCACCACTGCACTCCAGCCTGGATGACGGAGTAAGACTGTGTCTCAAAAATACTACTGCTACTACTACTAATTATTATTATTATTTCACTGTGATAACAAGTGTAATTAGATTAGTGGTTCTTGATCCTTAAGACGTAGTTAGAATTGCCTGAAAGATTTTCTAAAAATCAAAGCTCTCATGGCTTAGCCCAGATCAATTAAATTCATCGTCACAATTAGCTGCTATAACGATTAACATGCCCATTTTGGAGATGGGAACACGGAAGCTCAGAGAGATGATCTACTTGTCAGGATCACCCAGCTAGTCAGTGCTGGGGCTGGGATTTGGACCTGGGCAGTTGAATGCCACAGGCTCGGCTTCTTACCACTATGTGGGTGTTTTCCAGGTACACAGTTTGCCCAGGTTCTTCAGTGCAACAAGGGGGAGGGTGTCTTGGCCCGTGGCATAAAAGAAGGATGGGGTGGAGGGGGAAGCCCAGGTAACTTGAGCTTGGTAAGTCTCATCGTGCAATGGTGCTTGAAATGCTGCTATTTTCCAGCTTGATCAAAATGCTGTCATGCTTATTACCTGGGACTTTCTGCATGAGGACAAGGACCTGGTCTGTTAGAGCAGGAGTCCTCAACCCCCAGGCCACAGACTGGTACCAGTCTGCAGCCTCTTAGGAACTGGGCCATACAGCAGGAGGTGAGCGCAGGGCAGGTGAGCAGAGTGTCATCTGTGTTTATAGCCACTCCCCATCACTCCCATCACCGCCTGAGCTCCACCTCCTGCCAAATCAGCAGCAGCAATAGATTCTCAAAGGAGCACGAACACTTGTGAACTGTGCATGTGAGGAATCTGGGTTGCGTGTTCCTTATAAGAATCTAATGCCTGATGATCTCTGTCTCCCATCACCCGCTTTGGGGCCATCTAGTTGACGGAAAGCAAGCTCAGGGCTCCCACTGGTTCTACGTTATGGTGAGTTGTATAATTATTTCATTATATAGTACAATGTAATAATAATAAAGGGCACAATAAATGGAATGTGTTTGAATCATCCCAAAACCACGCGCCTCTCCCCGGTCCGTGGGAAAACTGTCTTCCACAAAACCAGTCCCTGGTGCCAAAAAGCTTGGGGACCACTGTGTTAGAGTGTTCCCTGTTGTACACCCAGGATGGTACAAAGTGGGCGCTCAGTGAGTGGTCGCTGAATGGCTAGCAGAAAGAAGAGCAGCACGGTGCCAGTTTCCAAGTGACACGCAGATGGCGTGATCTGCACGTGTCATCCATTGCCCGCAGCCCCCATCTCCCCCCAGTACTGATGCTGGCTTGCCATTATGGGCTGGGGTGGCCCCCACATCCCCCATCCCTCCCACACCCCTCCTGCCAGACTCAGCACTCACCGCTTCCAGAGGAACTTGAGTCTACGACACCAGGGTCAACTTCTTCCAGGCAGAGGAAGGTGACCAGACGGTCAAAGGACACCCGGGCCTAGGAAAACCGAAGCCGCAGGTCACCCAGCAAGAAGAGCAAAGAACTCAGGTTTTGGGTGTCGGTGTCTCAAGATGTGTGGCAACAGCTTCCTGTCTACCAAGCTCTGTGCATAGGAGGCGTGAGGACAAAGCTTTCTAGTTCATGGGAAACGATGCAACCCGAGTGGTGACCTTGATGGTGGTGATCTCCCACCTCTGCGATCCTACAAATCAGTGACACCGAAGCAAGCCAGCTGCCATTCTGCAGACAAGATCTGGGAAGAGGATGGTGGCTTTTCCAATAAGGTTATCAAGCCATTGTGTGGAACAATTTCAAATGTTGTCCACCTGGGGGCGCTCTCTCCCAGTCACAAACCCATCTTTGGGGAAGAAAGAGACCAGTCGTTAAAATAGAGATTAGGCCAGGTGCAGCGGCTCATGCCGGTAATCCCAGCACTTTGGGAAGCCAAGTGCAGGAGGATCACTTGAGGCCAGGAGTTGGAGACCTGGGGAACATAGCAAGACTCTTTGTTTCTACAAAAAATTAAAAAAATTAGCCGGATGTGGTGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGGGAGGTAGAAGCATCACTTGAGTCCAGGAGTTTGAGCATGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACACTGTCTCAATAAATAAATTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAGGCGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCTTATTACATGAGGTCGGGGGTTCAAGACCAGCCTGGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAACACAATAAATAAATAAATAAGACTGGGTGCAGTGGCTCATGTCTGTAATCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAGCGGTTCAAGACCTGCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGG
AAGAAATCTCTCCCACTGAACAAATTGCCCTGCTACTCACTGGCTTGTGGGTGACCCCGCAGGGTTCTTGTTCTGTCCGTGTCCCATGGCTACATAATCCAGGGGGAGGCAAACTGTGGCCCAGAGACCAAATCCTGCCTGCTGCCTTTTCTTATAAATAAAGTTTTATTGGAACACGGCCACATCCATTCATTTCTCTATTTCATGCTTTGAGCAGTTGTGACAGAGACTGTGTGGCCCACAGGCCTAAAATATGCACAATCTGGTCATTTATGGAAAAAGTTAGTGAATTTCTGAAATAAATTATCATCAAATCCCAGCCTTCCCAGAGTGAAGGGGGTGTTATTAATTTCACTGTGGCCGGCACAGTGTCTCATGCCTGTAATCCCAGCACTTTAGGAAGCAGAGGTGGTAGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGCCTCTACCAAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCACAGCTACTTGAGAGGCTAAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATTGCACCACTGCACTCCAGCCTGGATGACGGAGTAAGACTGTGTCTCAAAAATACTACTGCTACTACTACTAATTATTATTATTATTTCACTGTGATAACAAGTGTAATTAGATTAGTGGTTCTTGATCCTTAAGACGTAGTTAGAATTGCCTGAAAGATTTTCTAAAAATCAAAGCTCTCATGGCTTAGCCCAGATCAATTAAATTCATCGTCACAATTAGCTGCTATAACGATTAACATGCCCATTTTGGAGATGGGAACACGGAAGCTCAGAGAGATGATCTACTTGTCAGGATCACCCAGCTAGTCAGTGCTGGGGCTGGGATTTGGACCTGGGCAGTTGAATGCCACAGGCTCGGCTTCTTACCACTATGTGGGTGTTTTCCAGGTACACAGTTTGCCCAGGTTCTTCAGTGCAACAAGGGGGAGGGTGTCTTGGCCCGTGGCATAAAAGAAGGATGGGGTGGAGGGGGAAGCCCAGGTAACTTGAGCTTGGTAAGTCTCATCGTGCAATGGTGCTTGAAATGCTGCTATTTTCCAGCTTGATCAAAATGCTGTCATGCTTATTACCTGGGACTTTCTGCATGAGGACAAGGACCTGGTCTGTTAGAGCAGGAGTCCTCAACCCCCAGGCCACAGACTGGTACCAGTCTGCAGCCTCTTAGGAACTGGGCCATACAGCAGGAGGTGAGCGCAGGGCAGGTGAGCAGAGTGTCATCTGTGTTTATAGCCACTCCCCATCACTCCCATCACCGCCTGAGCTCCACCTCCTGCCAAATCAGCAGCAGCAATAGATTCTCAAAGGAGCACGAACACTTGTGAACTGTGCATGTGAGGAATCTGGGTTGCGTGTTCCTTATAAGAATCTAATGCCTGATGATCTCTGTCTCCCATCACCCGCTTTGGGGCCATCTAGTTGACGGAAAGCAAGCTCAGGGCTCCCACTGGTTCTACGTTATGGTGAGTTGTATAATTATTTCATTATATAGTACAATGTAATAATAATAAAGGGCACAATAAATGGAATGTGTTTGAATCATCCCAAAACCACGCGCCTCTCCCCGGTCCGTGGGAAAACTGTCTTCCACAAAACCAGTCCCTGGTGCCAAAAAGCTTGGGGACCACTGTGTTAGAGTGTTCCCTGTTGTACACCCAGGATGGTACAAAGTGGGCGCTCAGTGAGTGGTCGCTGAATGGCTAGCAGAAAGAAGAGCAGCACGGTGCCAGTTTCCAAGTGACACGCAGATGGCGTGATCTGCACGTGTCATCCATTGCCCGCAGCCCCCATCTCCCCCCAGTACTGATGCTGGCTTGCCATTATGGGCTGGGGTGGCCCCCACATCCCCCATCCCTCCCACACCCCTCCTGCCAGACTCAGCACTCACCGCTTCCAGAGGAACTTGAGTCTACGACACCAGGGTCAACTTCTTCCAGGCAGAGGAAGGTGACCAGACAGTCAAAGGACACCCGGGCCTAGGAAAACCGAAGCCGCAGGTCACCCAGCAAGAAGAGCAAAGAACTCAGGTTTTGGGTGTCGGTGTCTCAAGATGTGTGGCAACAGCTTCCTGTCTACCAAGCTCTGTGCATAGGAGGCGTGAGGACAAAGCTTTCTAGTTCATGGGAAACGATGCAACCCGAGTGGTGACCTTGATGGTGGTGATCTCCCACCTCTGCGATCCTACAAATCAGTGACACCGAAGCAAGCCAGCTGCCATTCTGCAGACAAGATCTGGGAAGAGGATGGTGGCTTTTCCAATAAGGTTATCAAGCCATTGTGTGGAACAATTTCAAATGTTGTCCACCTGGGGGCGCTCTCTCCCAGTCACAAACCCATCTTTGGGGAAGAAAGAGACCAGTCGTTAAAATAGAGATTAGGCCAGGTGCAGCGGCTCATGCCGGTAATCCCAGCACTTTGGGAAGCCAAGTGCAGGAGGATCACTTGAGGCCAGGAGTTGGAGACCTGGGGAACATAGCAAGACTCTTTGTTTCTACAAAAAATTAAAAAAATTAGCCGGATGTGGTGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGGGAGGTAGAAGCATCACTTGAGTCCAGGAGTTTGAGCATGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACACTGTCTCAATAAATAAATTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAGGCGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCTTATTACATGAGGTCGGGGGTTCAAGACCAGCCTGGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAACACAATAAATAAATAAATAAGACTGGGTGCAGTGGCTCATGTCTGTAATCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAGCGGTTCAAGACCTGCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGG
Task1_train_22427
An alteration has been detected in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Pseudoxanthoma elasticum, forme fruste
AAGAAATCTCTCCCACTGAACAAATTGCCCTGCTACTCACTGGCTTGTGGGTGACCCCGCAGGGTTCTTGTTCTGTCCGTGTCCCATGGCTACATAATCCAGGGGGAGGCAAACTGTGGCCCAGAGACCAAATCCTGCCTGCTGCCTTTTCTTATAAATAAAGTTTTATTGGAACACGGCCACATCCATTCATTTCTCTATTTCATGCTTTGAGCAGTTGTGACAGAGACTGTGTGGCCCACAGGCCTAAAATATGCACAATCTGGTCATTTATGGAAAAAGTTAGTGAATTTCTGAAATAAATTATCATCAAATCCCAGCCTTCCCAGAGTGAAGGGGGTGTTATTAATTTCACTGTGGCCGGCACAGTGTCTCATGCCTGTAATCCCAGCACTTTAGGAAGCAGAGGTGGTAGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGCCTCTACCAAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCACAGCTACTTGAGAGGCTAAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATTGCACCACTGCACTCCAGCCTGGATGACGGAGTAAGACTGTGTCTCAAAAATACTACTGCTACTACTACTAATTATTATTATTATTTCACTGTGATAACAAGTGTAATTAGATTAGTGGTTCTTGATCCTTAAGACGTAGTTAGAATTGCCTGAAAGATTTTCTAAAAATCAAAGCTCTCATGGCTTAGCCCAGATCAATTAAATTCATCGTCACAATTAGCTGCTATAACGATTAACATGCCCATTTTGGAGATGGGAACACGGAAGCTCAGAGAGATGATCTACTTGTCAGGATCACCCAGCTAGTCAGTGCTGGGGCTGGGATTTGGACCTGGGCAGTTGAATGCCACAGGCTCGGCTTCTTACCACTATGTGGGTGTTTTCCAGGTACACAGTTTGCCCAGGTTCTTCAGTGCAACAAGGGGGAGGGTGTCTTGGCCCGTGGCATAAAAGAAGGATGGGGTGGAGGGGGAAGCCCAGGTAACTTGAGCTTGGTAAGTCTCATCGTGCAATGGTGCTTGAAATGCTGCTATTTTCCAGCTTGATCAAAATGCTGTCATGCTTATTACCTGGGACTTTCTGCATGAGGACAAGGACCTGGTCTGTTAGAGCAGGAGTCCTCAACCCCCAGGCCACAGACTGGTACCAGTCTGCAGCCTCTTAGGAACTGGGCCATACAGCAGGAGGTGAGCGCAGGGCAGGTGAGCAGAGTGTCATCTGTGTTTATAGCCACTCCCCATCACTCCCATCACCGCCTGAGCTCCACCTCCTGCCAAATCAGCAGCAGCAATAGATTCTCAAAGGAGCACGAACACTTGTGAACTGTGCATGTGAGGAATCTGGGTTGCGTGTTCCTTATAAGAATCTAATGCCTGATGATCTCTGTCTCCCATCACCCGCTTTGGGGCCATCTAGTTGACGGAAAGCAAGCTCAGGGCTCCCACTGGTTCTACGTTATGGTGAGTTGTATAATTATTTCATTATATAGTACAATGTAATAATAATAAAGGGCACAATAAATGGAATGTGTTTGAATCATCCCAAAACCACGCGCCTCTCCCCGGTCCGTGGGAAAACTGTCTTCCACAAAACCAGTCCCTGGTGCCAAAAAGCTTGGGGACCACTGTGTTAGAGTGTTCCCTGTTGTACACCCAGGATGGTACAAAGTGGGCGCTCAGTGAGTGGTCGCTGAATGGCTAGCAGAAAGAAGAGCAGCACGGTGCCAGTTTCCAAGTGACACGCAGATGGCGTGATCTGCACGTGTCATCCATTGCCCGCAGCCCCCATCTCCCCCCAGTACTGATGCTGGCTTGCCATTATGGGCTGGGGTGGCCCCCACATCCCCCATCCCTCCCACACCCCTCCTGCCAGACTCAGCACTCACCGCTTCCAGAGGAACTTGAGTCTACGACACCAGGGTCAACTTCTTCCAGGCAGAGGAAGGTGACCAGACGGTCAAAGGACACCCGGGCCTAGGAAAACCGAAGCCGCAGGTCACCCAGCAAGAAGAGCAAAGAACTCAGGTTTTGGGTGTCGGTGTCTCAAGATGTGTGGCAACAGCTTCCTGTCTACCAAGCTCTGTGCATAGGAGGCGTGAGGACAAAGCTTTCTAGTTCATGGGAAACGATGCAACCCGAGTGGTGACCTTGATGGTGGTGATCTCCCACCTCTGCGATCCTACAAATCAGTGACACCGAAGCAAGCCAGCTGCCATTCTGCAGACAAGATCTGGGAAGAGGATGGTGGCTTTTCCAATAAGGTTATCAAGCCATTGTGTGGAACAATTTCAAATGTTGTCCACCTGGGGGCGCTCTCTCCCAGTCACAAACCCATCTTTGGGGAAGAAAGAGACCAGTCGTTAAAATAGAGATTAGGCCAGGTGCAGCGGCTCATGCCGGTAATCCCAGCACTTTGGGAAGCCAAGTGCAGGAGGATCACTTGAGGCCAGGAGTTGGAGACCTGGGGAACATAGCAAGACTCTTTGTTTCTACAAAAAATTAAAAAAATTAGCCGGATGTGGTGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGGGAGGTAGAAGCATCACTTGAGTCCAGGAGTTTGAGCATGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACACTGTCTCAATAAATAAATTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAGGCGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCTTATTACATGAGGTCGGGGGTTCAAGACCAGCCTGGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAACACAATAAATAAATAAATAAGACTGGGTGCAGTGGCTCATGTCTGTAATCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAGCGGTTCAAGACCTGCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGG
AAGAAATCTCTCCCACTGAACAAATTGCCCTGCTACTCACTGGCTTGTGGGTGACCCCGCAGGGTTCTTGTTCTGTCCGTGTCCCATGGCTACATAATCCAGGGGGAGGCAAACTGTGGCCCAGAGACCAAATCCTGCCTGCTGCCTTTTCTTATAAATAAAGTTTTATTGGAACACGGCCACATCCATTCATTTCTCTATTTCATGCTTTGAGCAGTTGTGACAGAGACTGTGTGGCCCACAGGCCTAAAATATGCACAATCTGGTCATTTATGGAAAAAGTTAGTGAATTTCTGAAATAAATTATCATCAAATCCCAGCCTTCCCAGAGTGAAGGGGGTGTTATTAATTTCACTGTGGCCGGCACAGTGTCTCATGCCTGTAATCCCAGCACTTTAGGAAGCAGAGGTGGTAGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGCCTCTACCAAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCACAGCTACTTGAGAGGCTAAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATTGCACCACTGCACTCCAGCCTGGATGACGGAGTAAGACTGTGTCTCAAAAATACTACTGCTACTACTACTAATTATTATTATTATTTCACTGTGATAACAAGTGTAATTAGATTAGTGGTTCTTGATCCTTAAGACGTAGTTAGAATTGCCTGAAAGATTTTCTAAAAATCAAAGCTCTCATGGCTTAGCCCAGATCAATTAAATTCATCGTCACAATTAGCTGCTATAACGATTAACATGCCCATTTTGGAGATGGGAACACGGAAGCTCAGAGAGATGATCTACTTGTCAGGATCACCCAGCTAGTCAGTGCTGGGGCTGGGATTTGGACCTGGGCAGTTGAATGCCACAGGCTCGGCTTCTTACCACTATGTGGGTGTTTTCCAGGTACACAGTTTGCCCAGGTTCTTCAGTGCAACAAGGGGGAGGGTGTCTTGGCCCGTGGCATAAAAGAAGGATGGGGTGGAGGGGGAAGCCCAGGTAACTTGAGCTTGGTAAGTCTCATCGTGCAATGGTGCTTGAAATGCTGCTATTTTCCAGCTTGATCAAAATGCTGTCATGCTTATTACCTGGGACTTTCTGCATGAGGACAAGGACCTGGTCTGTTAGAGCAGGAGTCCTCAACCCCCAGGCCACAGACTGGTACCAGTCTGCAGCCTCTTAGGAACTGGGCCATACAGCAGGAGGTGAGCGCAGGGCAGGTGAGCAGAGTGTCATCTGTGTTTATAGCCACTCCCCATCACTCCCATCACCGCCTGAGCTCCACCTCCTGCCAAATCAGCAGCAGCAATAGATTCTCAAAGGAGCACGAACACTTGTGAACTGTGCATGTGAGGAATCTGGGTTGCGTGTTCCTTATAAGAATCTAATGCCTGATGATCTCTGTCTCCCATCACCCGCTTTGGGGCCATCTAGTTGACGGAAAGCAAGCTCAGGGCTCCCACTGGTTCTACGTTATGGTGAGTTGTATAATTATTTCATTATATAGTACAATGTAATAATAATAAAGGGCACAATAAATGGAATGTGTTTGAATCATCCCAAAACCACGCGCCTCTCCCCGGTCCGTGGGAAAACTGTCTTCCACAAAACCAGTCCCTGGTGCCAAAAAGCTTGGGGACCACTGTGTTAGAGTGTTCCCTGTTGTACACCCAGGATGGTACAAAGTGGGCGCTCAGTGAGTGGTCGCTGAATGGCTAGCAGAAAGAAGAGCAGCACGGTGCCAGTTTCCAAGTGACACGCAGATGGCGTGATCTGCACGTGTCATCCATTGCCCGCAGCCCCCATCTCCCCCCAGTACTGATGCTGGCTTGCCATTATGGGCTGGGGTGGCCCCCACATCCCCCATCCCTCCCACACCCCTCCTGCCAGACTCAGCACTCACCGCTTCCAGAGGAACTTGAGTCTACGACACCAGGGTCAACTTCTTCCAGGCAGAGGAAGGTGACCAGACAGTCAAAGGACACCCGGGCCTAGGAAAACCGAAGCCGCAGGTCACCCAGCAAGAAGAGCAAAGAACTCAGGTTTTGGGTGTCGGTGTCTCAAGATGTGTGGCAACAGCTTCCTGTCTACCAAGCTCTGTGCATAGGAGGCGTGAGGACAAAGCTTTCTAGTTCATGGGAAACGATGCAACCCGAGTGGTGACCTTGATGGTGGTGATCTCCCACCTCTGCGATCCTACAAATCAGTGACACCGAAGCAAGCCAGCTGCCATTCTGCAGACAAGATCTGGGAAGAGGATGGTGGCTTTTCCAATAAGGTTATCAAGCCATTGTGTGGAACAATTTCAAATGTTGTCCACCTGGGGGCGCTCTCTCCCAGTCACAAACCCATCTTTGGGGAAGAAAGAGACCAGTCGTTAAAATAGAGATTAGGCCAGGTGCAGCGGCTCATGCCGGTAATCCCAGCACTTTGGGAAGCCAAGTGCAGGAGGATCACTTGAGGCCAGGAGTTGGAGACCTGGGGAACATAGCAAGACTCTTTGTTTCTACAAAAAATTAAAAAAATTAGCCGGATGTGGTGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGGGAGGTAGAAGCATCACTTGAGTCCAGGAGTTTGAGCATGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACACTGTCTCAATAAATAAATTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAGGCGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCTTATTACATGAGGTCGGGGGTTCAAGACCAGCCTGGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAACACAATAAATAAATAAATAAGACTGGGTGCAGTGGCTCATGTCTGTAATCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAGCGGTTCAAGACCTGCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGG
Task1_train_22428
Assess the clinical impact of this variant on gene ABCC6 (ATP binding cassette subfamily C member 6), found on Chromosome 16. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Arterial calcification, generalized, of infancy, 2
AAGAAATCTCTCCCACTGAACAAATTGCCCTGCTACTCACTGGCTTGTGGGTGACCCCGCAGGGTTCTTGTTCTGTCCGTGTCCCATGGCTACATAATCCAGGGGGAGGCAAACTGTGGCCCAGAGACCAAATCCTGCCTGCTGCCTTTTCTTATAAATAAAGTTTTATTGGAACACGGCCACATCCATTCATTTCTCTATTTCATGCTTTGAGCAGTTGTGACAGAGACTGTGTGGCCCACAGGCCTAAAATATGCACAATCTGGTCATTTATGGAAAAAGTTAGTGAATTTCTGAAATAAATTATCATCAAATCCCAGCCTTCCCAGAGTGAAGGGGGTGTTATTAATTTCACTGTGGCCGGCACAGTGTCTCATGCCTGTAATCCCAGCACTTTAGGAAGCAGAGGTGGTAGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGCCTCTACCAAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCACAGCTACTTGAGAGGCTAAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATTGCACCACTGCACTCCAGCCTGGATGACGGAGTAAGACTGTGTCTCAAAAATACTACTGCTACTACTACTAATTATTATTATTATTTCACTGTGATAACAAGTGTAATTAGATTAGTGGTTCTTGATCCTTAAGACGTAGTTAGAATTGCCTGAAAGATTTTCTAAAAATCAAAGCTCTCATGGCTTAGCCCAGATCAATTAAATTCATCGTCACAATTAGCTGCTATAACGATTAACATGCCCATTTTGGAGATGGGAACACGGAAGCTCAGAGAGATGATCTACTTGTCAGGATCACCCAGCTAGTCAGTGCTGGGGCTGGGATTTGGACCTGGGCAGTTGAATGCCACAGGCTCGGCTTCTTACCACTATGTGGGTGTTTTCCAGGTACACAGTTTGCCCAGGTTCTTCAGTGCAACAAGGGGGAGGGTGTCTTGGCCCGTGGCATAAAAGAAGGATGGGGTGGAGGGGGAAGCCCAGGTAACTTGAGCTTGGTAAGTCTCATCGTGCAATGGTGCTTGAAATGCTGCTATTTTCCAGCTTGATCAAAATGCTGTCATGCTTATTACCTGGGACTTTCTGCATGAGGACAAGGACCTGGTCTGTTAGAGCAGGAGTCCTCAACCCCCAGGCCACAGACTGGTACCAGTCTGCAGCCTCTTAGGAACTGGGCCATACAGCAGGAGGTGAGCGCAGGGCAGGTGAGCAGAGTGTCATCTGTGTTTATAGCCACTCCCCATCACTCCCATCACCGCCTGAGCTCCACCTCCTGCCAAATCAGCAGCAGCAATAGATTCTCAAAGGAGCACGAACACTTGTGAACTGTGCATGTGAGGAATCTGGGTTGCGTGTTCCTTATAAGAATCTAATGCCTGATGATCTCTGTCTCCCATCACCCGCTTTGGGGCCATCTAGTTGACGGAAAGCAAGCTCAGGGCTCCCACTGGTTCTACGTTATGGTGAGTTGTATAATTATTTCATTATATAGTACAATGTAATAATAATAAAGGGCACAATAAATGGAATGTGTTTGAATCATCCCAAAACCACGCGCCTCTCCCCGGTCCGTGGGAAAACTGTCTTCCACAAAACCAGTCCCTGGTGCCAAAAAGCTTGGGGACCACTGTGTTAGAGTGTTCCCTGTTGTACACCCAGGATGGTACAAAGTGGGCGCTCAGTGAGTGGTCGCTGAATGGCTAGCAGAAAGAAGAGCAGCACGGTGCCAGTTTCCAAGTGACACGCAGATGGCGTGATCTGCACGTGTCATCCATTGCCCGCAGCCCCCATCTCCCCCCAGTACTGATGCTGGCTTGCCATTATGGGCTGGGGTGGCCCCCACATCCCCCATCCCTCCCACACCCCTCCTGCCAGACTCAGCACTCACCGCTTCCAGAGGAACTTGAGTCTACGACACCAGGGTCAACTTCTTCCAGGCAGAGGAAGGTGACCAGACGGTCAAAGGACACCCGGGCCTAGGAAAACCGAAGCCGCAGGTCACCCAGCAAGAAGAGCAAAGAACTCAGGTTTTGGGTGTCGGTGTCTCAAGATGTGTGGCAACAGCTTCCTGTCTACCAAGCTCTGTGCATAGGAGGCGTGAGGACAAAGCTTTCTAGTTCATGGGAAACGATGCAACCCGAGTGGTGACCTTGATGGTGGTGATCTCCCACCTCTGCGATCCTACAAATCAGTGACACCGAAGCAAGCCAGCTGCCATTCTGCAGACAAGATCTGGGAAGAGGATGGTGGCTTTTCCAATAAGGTTATCAAGCCATTGTGTGGAACAATTTCAAATGTTGTCCACCTGGGGGCGCTCTCTCCCAGTCACAAACCCATCTTTGGGGAAGAAAGAGACCAGTCGTTAAAATAGAGATTAGGCCAGGTGCAGCGGCTCATGCCGGTAATCCCAGCACTTTGGGAAGCCAAGTGCAGGAGGATCACTTGAGGCCAGGAGTTGGAGACCTGGGGAACATAGCAAGACTCTTTGTTTCTACAAAAAATTAAAAAAATTAGCCGGATGTGGTGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGGGAGGTAGAAGCATCACTTGAGTCCAGGAGTTTGAGCATGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACACTGTCTCAATAAATAAATTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAGGCGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCTTATTACATGAGGTCGGGGGTTCAAGACCAGCCTGGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAACACAATAAATAAATAAATAAGACTGGGTGCAGTGGCTCATGTCTGTAATCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAGCGGTTCAAGACCTGCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGG
AAGAAATCTCTCCCACTGAACAAATTGCCCTGCTACTCACTGGCTTGTGGGTGACCCCGCAGGGTTCTTGTTCTGTCCGTGTCCCATGGCTACATAATCCAGGGGGAGGCAAACTGTGGCCCAGAGACCAAATCCTGCCTGCTGCCTTTTCTTATAAATAAAGTTTTATTGGAACACGGCCACATCCATTCATTTCTCTATTTCATGCTTTGAGCAGTTGTGACAGAGACTGTGTGGCCCACAGGCCTAAAATATGCACAATCTGGTCATTTATGGAAAAAGTTAGTGAATTTCTGAAATAAATTATCATCAAATCCCAGCCTTCCCAGAGTGAAGGGGGTGTTATTAATTTCACTGTGGCCGGCACAGTGTCTCATGCCTGTAATCCCAGCACTTTAGGAAGCAGAGGTGGTAGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGCCTCTACCAAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCACAGCTACTTGAGAGGCTAAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAACCAAGATTGCACCACTGCACTCCAGCCTGGATGACGGAGTAAGACTGTGTCTCAAAAATACTACTGCTACTACTACTAATTATTATTATTATTTCACTGTGATAACAAGTGTAATTAGATTAGTGGTTCTTGATCCTTAAGACGTAGTTAGAATTGCCTGAAAGATTTTCTAAAAATCAAAGCTCTCATGGCTTAGCCCAGATCAATTAAATTCATCGTCACAATTAGCTGCTATAACGATTAACATGCCCATTTTGGAGATGGGAACACGGAAGCTCAGAGAGATGATCTACTTGTCAGGATCACCCAGCTAGTCAGTGCTGGGGCTGGGATTTGGACCTGGGCAGTTGAATGCCACAGGCTCGGCTTCTTACCACTATGTGGGTGTTTTCCAGGTACACAGTTTGCCCAGGTTCTTCAGTGCAACAAGGGGGAGGGTGTCTTGGCCCGTGGCATAAAAGAAGGATGGGGTGGAGGGGGAAGCCCAGGTAACTTGAGCTTGGTAAGTCTCATCGTGCAATGGTGCTTGAAATGCTGCTATTTTCCAGCTTGATCAAAATGCTGTCATGCTTATTACCTGGGACTTTCTGCATGAGGACAAGGACCTGGTCTGTTAGAGCAGGAGTCCTCAACCCCCAGGCCACAGACTGGTACCAGTCTGCAGCCTCTTAGGAACTGGGCCATACAGCAGGAGGTGAGCGCAGGGCAGGTGAGCAGAGTGTCATCTGTGTTTATAGCCACTCCCCATCACTCCCATCACCGCCTGAGCTCCACCTCCTGCCAAATCAGCAGCAGCAATAGATTCTCAAAGGAGCACGAACACTTGTGAACTGTGCATGTGAGGAATCTGGGTTGCGTGTTCCTTATAAGAATCTAATGCCTGATGATCTCTGTCTCCCATCACCCGCTTTGGGGCCATCTAGTTGACGGAAAGCAAGCTCAGGGCTCCCACTGGTTCTACGTTATGGTGAGTTGTATAATTATTTCATTATATAGTACAATGTAATAATAATAAAGGGCACAATAAATGGAATGTGTTTGAATCATCCCAAAACCACGCGCCTCTCCCCGGTCCGTGGGAAAACTGTCTTCCACAAAACCAGTCCCTGGTGCCAAAAAGCTTGGGGACCACTGTGTTAGAGTGTTCCCTGTTGTACACCCAGGATGGTACAAAGTGGGCGCTCAGTGAGTGGTCGCTGAATGGCTAGCAGAAAGAAGAGCAGCACGGTGCCAGTTTCCAAGTGACACGCAGATGGCGTGATCTGCACGTGTCATCCATTGCCCGCAGCCCCCATCTCCCCCCAGTACTGATGCTGGCTTGCCATTATGGGCTGGGGTGGCCCCCACATCCCCCATCCCTCCCACACCCCTCCTGCCAGACTCAGCACTCACCGCTTCCAGAGGAACTTGAGTCTACGACACCAGGGTCAACTTCTTCCAGGCAGAGGAAGGTGACCAGACAGTCAAAGGACACCCGGGCCTAGGAAAACCGAAGCCGCAGGTCACCCAGCAAGAAGAGCAAAGAACTCAGGTTTTGGGTGTCGGTGTCTCAAGATGTGTGGCAACAGCTTCCTGTCTACCAAGCTCTGTGCATAGGAGGCGTGAGGACAAAGCTTTCTAGTTCATGGGAAACGATGCAACCCGAGTGGTGACCTTGATGGTGGTGATCTCCCACCTCTGCGATCCTACAAATCAGTGACACCGAAGCAAGCCAGCTGCCATTCTGCAGACAAGATCTGGGAAGAGGATGGTGGCTTTTCCAATAAGGTTATCAAGCCATTGTGTGGAACAATTTCAAATGTTGTCCACCTGGGGGCGCTCTCTCCCAGTCACAAACCCATCTTTGGGGAAGAAAGAGACCAGTCGTTAAAATAGAGATTAGGCCAGGTGCAGCGGCTCATGCCGGTAATCCCAGCACTTTGGGAAGCCAAGTGCAGGAGGATCACTTGAGGCCAGGAGTTGGAGACCTGGGGAACATAGCAAGACTCTTTGTTTCTACAAAAAATTAAAAAAATTAGCCGGATGTGGTGGCCCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGGGAGGTAGAAGCATCACTTGAGTCCAGGAGTTTGAGCATGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACACTGTCTCAATAAATAAATTAAATAAATAAATAAATAAATAAATAAATAAATAAATAAGGCGGCCAGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCTTATTACATGAGGTCGGGGGTTCAAGACCAGCCTGGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAACACAATAAATAAATAAATAAGACTGGGTGCAGTGGCTCATGTCTGTAATCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAGCGGTTCAAGACCTGCCTGGCCAACATGGTGAAATCTCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGG
Task1_train_22429
This mutation occurs in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Does this change lead to a known medical condition, or is it benign?
Pathogenic; not provided
GCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGGGGAGAACCTAATGCCTCTAGGTTCCAGGCATCGGGGGACAGCAGAGTTTTTGATCTTGGTAGCCCTGTTGTTCTAGACGTGGTGGAACTTGTGATTCTAGAGTCCCTTGGAAGATGACTCTAAAGTTGCAGGCAGGAGCAGCACTTGAGGGCTCTAGGTGTTGGTGCCATTTGTGGTGCTTTTTTTTTTTTTTTTGAGATGAAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGCATGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGACTCCCAAGTAGCTGGGATTACAGGCGCCCGCCACTGCAACCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTATTGGGACGACAGGCATGAGCCACCACACCCAGCCTACGTATCAAATTTTTTAAAACTGTGGTTTAGGAAGGTTGTTCTGACAGCAATATGAAATAAATTACAGAATGGCAGGACAAGGATCACGTCCAGTGACAGGGTGGCTATGGACATCTGCTGGCCAGGATCAGGGAAGTCACTCTGACCCAGGATTCTACCTCTGCCACCCCCCTGCATCTGTACCCTCCTCCCCACATCGGTAGAAGCCTGGAACTCTCTCTGAGAGTTCAGCAGACTTTATCAGCCACTGCCACCTTTGCTAGAATAATATGATTAATTAGTTCTTGTAGAAGACAGCAGGGACCCAGAGAGAACAGGATCCAGAATGAGTGGGTTTTGATGGACGGGGTGGTAGGATCTGGGGGGCTCCACCTACCTCACCCTGCCCCCACCCCCGCACTCCTTCCCCAGTGCTGCTCAGCATAGAGACTAGAGTGACGTCACCAGAAATGTAGACACTTGGAAGGACACCAGCGACACAGAGAAGAGGAGGCCGGAGGTCCGCAAGGCGCCCAGCTCCTGGCCTCGGATGCCCAGGACTCTGTCCAGAAAGGCTCCCTCCCAGCCATGGAACTTGATGGTCTTCGAGTTCCTGAGGATAGAGCTGGTGAGCCGTGCCCGTGAGTCCTTCTGCCTCATTTGCTCCTCCTGGGATCGGAGGGAAAAAGAGAGATGAAGACAGGGACAGTTGAGAACTCTTCCCTGCACCCTGACAGCCACCCTTCAGCAAATCCCATTCATCTCACCAAACTGCGTCCCAAACCTGTCTGCCTCTCAGCACCTCTGACCCTCACTCCTGGTCCAACCACCATCATCCTGTACCTGGACTTCTGCAGGAGTGCCCCTGGGATAATGTGCCCCATGGAGGAAGCCTCTGATGCCCGGAGAACAGAGGCAGCCTGAGCCCACCTGGGTATGACACCATCAGGAAGGCTACCTGGAGGTGGTTGATGCCTGAGCTACGTCTTTTTTTTTTTTTACCTTTTACATTTTTTGTGGAGTTGGGGTCTCACTATGTTGCCCAGGTTGGCCTCGAGCTCCTGGGCTCAAGTGATCCTCTGCCCTCAGCCTCCTAAAATGCTGGGATTACAGCCTGAGCTAAATCTTAAATGACCAGGAAGTGCGTGCTGAGCAGGCAGAGGATGGGGGGATGGAGCTGGAGAAGAGGGAGGGGAGGGGCTTGAGATGGGGGTGGGGGGTGGGGGCTGGGGGGTAGGGGGGTGGCGGGGGCACCTAAAACCCAGGCACAGGGAATAGCATGACTCAGAGGACACTCAGTGTGACCAGAGGAGCGTGTGGGCAGGGTCACTTGGCACTTTAAAGTCAGGCAGAAGAATTCAGGGTCTCCTGTGCTTCACCATGGGGCGGGGGGCATCATCAGAGGGGCAGCTGCCTGGAGAAGGTTTTACTTTTTGAGACCGAGTCTTCCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGGTCTCGGCTCACTGTAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTGAGCTTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAAATTTTGTATTTTTTGTGGAGGCAGGGTTATGCCATGTTGGCCAGGCTGGTTTTGAACTCCTGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGGCCTCCCAAAGTGCTGGGATTACAGGTGTCAGCCACTGTGCCCAGCCTAGAATGTTTTAGAGGAGTCCACGCAGGAGGCTGAAGAAACAGCCCAGGTGACAGACGGACACTGGGACAGCTGGGCCAAGAGAGGAAATAAGTTCCTTCCCTCCATCCCCCATCTCTCCCTCTCTCTTTCCCGCCTTTTCTTTCCTTCCTTCCCTATCTCCTTTCTTCCTCTTTCCTTTGCTTTCTTCCCTCTTTCCTTTTATTTCCTTCCCTCCCTCCCCCCTTTCTTCCTTCTCTCCCTCATTCCTTCTCTTCCGCCCTCAATTCTTTCCTTCCCTCCTTCCCTCTGTCCTTCCTCCCCTTTCCTATCTTTCCTTCCCTCCCTCCTTTTCTCTCCTTCCCCTCCCTCCTTCCTCTCCTCCTTTCCTTCTTCCCTCCCTCCTTTCTTCCATAGTTCACAAACACTTACTGAGAACCTTCTGCCTGCCAAGCACTAACTAGATGCCGAGTTGGCCACAATCAGTGGCCTGTGCTGTTGCAAAGCTTCCAGTTAAGGAAAACAAGGCAATCAACCCTGCCGGGTGCTTCCTGTAGGACCCTGTAGGTTGTGGGAAGTGCTGTGGGGGGAAAAAAGCAAAAACAATCCCAGGGCAGGCAAAGGAGAGGCTGCTGCTGGGAGGGGAGGGATGGACGTGCCATTTCCTTGCTGGAGGGTGGTGAGGGAAGCCGCCCTGACTGCAGGGAGGTGACAGAGGATCTTCGGGAGTGAGGGTGATCCAGGTGGAGGGAACAGCTAAAGCGAAGGCCTGCAGGGATGTGTGAGATCGGGCAGGTTTGAGGATGGGAGATGTGTGGGGAAAGGCAGGGAAGGAGGGGAGATGGGTAGAAGGTGAGGTTGGAAGCAATAAGGCCAGCTCAGGGCGGGCCTGGTGGGCCACTGTGGGGTCTTTGGCTC
GCTGGGCATGGTTGTGCATGCCTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGGGGAGAACCTAATGCCTCTAGGTTCCAGGCATCGGGGGACAGCAGAGTTTTTGATCTTGGTAGCCCTGTTGTTCTAGACGTGGTGGAACTTGTGATTCTAGAGTCCCTTGGAAGATGACTCTAAAGTTGCAGGCAGGAGCAGCACTTGAGGGCTCTAGGTGTTGGTGCCATTTGTGGTGCTTTTTTTTTTTTTTTTGAGATGAAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGCATGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGACTCCCAAGTAGCTGGGATTACAGGCGCCCGCCACTGCAACCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTATTGGGACGACAGGCATGAGCCACCACACCCAGCCTACGTATCAAATTTTTTAAAACTGTGGTTTAGGAAGGTTGTTCTGACAGCAATATGAAATAAATTACAGAATGGCAGGACAAGGATCACGTCCAGTGACAGGGTGGCTATGGACATCTGCTGGCCAGGATCAGGGAAGTCACTCTGACCCAGGATTCTACCTCTGCCACCCCCCTGCATCTGTACCCTCCTCCCCACATCGGTAGAAGCCTGGAACTCTCTCTGAGAGTTCAGCAGACTTTATCAGCCACTGCCACCTTTGCTAGAATAATATGATTAATTAGTTCTTGTAGAAGACAGCAGGGACCCAGAGAGAACAGGATCCAGAATGAGTGGGTTTTGATGGACGGGGTGGTAGGATCTGGGGGGCTCCACCTACCTCACCCTGCCCCCACCCCCGCACTCCTTCCCCAGTGCTGCTCAGCATAGAGACTAGAGTGACGTCACCAGAAATGTAGACACTTGGAAGGACACCAGCGACACAGAGAAGAGGAGGCCGGAGGTCCGCAAGGCGCCCAGCTCCTGGCCTCGGATGCCCAGGACTCTGTCCAGAAAGGCTCCCTCCCAGCCATGGAACCTGATGGTCTTCGAGTTCCTGAGGATAGAGCTGGTGAGCCGTGCCCGTGAGTCCTTCTGCCTCATTTGCTCCTCCTGGGATCGGAGGGAAAAAGAGAGATGAAGACAGGGACAGTTGAGAACTCTTCCCTGCACCCTGACAGCCACCCTTCAGCAAATCCCATTCATCTCACCAAACTGCGTCCCAAACCTGTCTGCCTCTCAGCACCTCTGACCCTCACTCCTGGTCCAACCACCATCATCCTGTACCTGGACTTCTGCAGGAGTGCCCCTGGGATAATGTGCCCCATGGAGGAAGCCTCTGATGCCCGGAGAACAGAGGCAGCCTGAGCCCACCTGGGTATGACACCATCAGGAAGGCTACCTGGAGGTGGTTGATGCCTGAGCTACGTCTTTTTTTTTTTTTACCTTTTACATTTTTTGTGGAGTTGGGGTCTCACTATGTTGCCCAGGTTGGCCTCGAGCTCCTGGGCTCAAGTGATCCTCTGCCCTCAGCCTCCTAAAATGCTGGGATTACAGCCTGAGCTAAATCTTAAATGACCAGGAAGTGCGTGCTGAGCAGGCAGAGGATGGGGGGATGGAGCTGGAGAAGAGGGAGGGGAGGGGCTTGAGATGGGGGTGGGGGGTGGGGGCTGGGGGGTAGGGGGGTGGCGGGGGCACCTAAAACCCAGGCACAGGGAATAGCATGACTCAGAGGACACTCAGTGTGACCAGAGGAGCGTGTGGGCAGGGTCACTTGGCACTTTAAAGTCAGGCAGAAGAATTCAGGGTCTCCTGTGCTTCACCATGGGGCGGGGGGCATCATCAGAGGGGCAGCTGCCTGGAGAAGGTTTTACTTTTTGAGACCGAGTCTTCCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGGTCTCGGCTCACTGTAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTGAGCTTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAAATTTTGTATTTTTTGTGGAGGCAGGGTTATGCCATGTTGGCCAGGCTGGTTTTGAACTCCTGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGGCCTCCCAAAGTGCTGGGATTACAGGTGTCAGCCACTGTGCCCAGCCTAGAATGTTTTAGAGGAGTCCACGCAGGAGGCTGAAGAAACAGCCCAGGTGACAGACGGACACTGGGACAGCTGGGCCAAGAGAGGAAATAAGTTCCTTCCCTCCATCCCCCATCTCTCCCTCTCTCTTTCCCGCCTTTTCTTTCCTTCCTTCCCTATCTCCTTTCTTCCTCTTTCCTTTGCTTTCTTCCCTCTTTCCTTTTATTTCCTTCCCTCCCTCCCCCCTTTCTTCCTTCTCTCCCTCATTCCTTCTCTTCCGCCCTCAATTCTTTCCTTCCCTCCTTCCCTCTGTCCTTCCTCCCCTTTCCTATCTTTCCTTCCCTCCCTCCTTTTCTCTCCTTCCCCTCCCTCCTTCCTCTCCTCCTTTCCTTCTTCCCTCCCTCCTTTCTTCCATAGTTCACAAACACTTACTGAGAACCTTCTGCCTGCCAAGCACTAACTAGATGCCGAGTTGGCCACAATCAGTGGCCTGTGCTGTTGCAAAGCTTCCAGTTAAGGAAAACAAGGCAATCAACCCTGCCGGGTGCTTCCTGTAGGACCCTGTAGGTTGTGGGAAGTGCTGTGGGGGGAAAAAAGCAAAAACAATCCCAGGGCAGGCAAAGGAGAGGCTGCTGCTGGGAGGGGAGGGATGGACGTGCCATTTCCTTGCTGGAGGGTGGTGAGGGAAGCCGCCCTGACTGCAGGGAGGTGACAGAGGATCTTCGGGAGTGAGGGTGATCCAGGTGGAGGGAACAGCTAAAGCGAAGGCCTGCAGGGATGTGTGAGATCGGGCAGGTTTGAGGATGGGAGATGTGTGGGGAAAGGCAGGGAAGGAGGGGAGATGGGTAGAAGGTGAGGTTGGAAGCAATAAGGCCAGCTCAGGGCGGGCCTGGTGGGCCACTGTGGGGTCTTTGGCTC
Task1_train_22430
This variant lies on Chromosome 16 and affects the gene ABCC6 (ATP binding cassette subfamily C member 6). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; ABCC6-related disorder
CTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGGGGAGAACCTAATGCCTCTAGGTTCCAGGCATCGGGGGACAGCAGAGTTTTTGATCTTGGTAGCCCTGTTGTTCTAGACGTGGTGGAACTTGTGATTCTAGAGTCCCTTGGAAGATGACTCTAAAGTTGCAGGCAGGAGCAGCACTTGAGGGCTCTAGGTGTTGGTGCCATTTGTGGTGCTTTTTTTTTTTTTTTTGAGATGAAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGCATGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGACTCCCAAGTAGCTGGGATTACAGGCGCCCGCCACTGCAACCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTATTGGGACGACAGGCATGAGCCACCACACCCAGCCTACGTATCAAATTTTTTAAAACTGTGGTTTAGGAAGGTTGTTCTGACAGCAATATGAAATAAATTACAGAATGGCAGGACAAGGATCACGTCCAGTGACAGGGTGGCTATGGACATCTGCTGGCCAGGATCAGGGAAGTCACTCTGACCCAGGATTCTACCTCTGCCACCCCCCTGCATCTGTACCCTCCTCCCCACATCGGTAGAAGCCTGGAACTCTCTCTGAGAGTTCAGCAGACTTTATCAGCCACTGCCACCTTTGCTAGAATAATATGATTAATTAGTTCTTGTAGAAGACAGCAGGGACCCAGAGAGAACAGGATCCAGAATGAGTGGGTTTTGATGGACGGGGTGGTAGGATCTGGGGGGCTCCACCTACCTCACCCTGCCCCCACCCCCGCACTCCTTCCCCAGTGCTGCTCAGCATAGAGACTAGAGTGACGTCACCAGAAATGTAGACACTTGGAAGGACACCAGCGACACAGAGAAGAGGAGGCCGGAGGTCCGCAAGGCGCCCAGCTCCTGGCCTCGGATGCCCAGGACTCTGTCCAGAAAGGCTCCCTCCCAGCCATGGAACTTGATGGTCTTCGAGTTCCTGAGGATAGAGCTGGTGAGCCGTGCCCGTGAGTCCTTCTGCCTCATTTGCTCCTCCTGGGATCGGAGGGAAAAAGAGAGATGAAGACAGGGACAGTTGAGAACTCTTCCCTGCACCCTGACAGCCACCCTTCAGCAAATCCCATTCATCTCACCAAACTGCGTCCCAAACCTGTCTGCCTCTCAGCACCTCTGACCCTCACTCCTGGTCCAACCACCATCATCCTGTACCTGGACTTCTGCAGGAGTGCCCCTGGGATAATGTGCCCCATGGAGGAAGCCTCTGATGCCCGGAGAACAGAGGCAGCCTGAGCCCACCTGGGTATGACACCATCAGGAAGGCTACCTGGAGGTGGTTGATGCCTGAGCTACGTCTTTTTTTTTTTTTACCTTTTACATTTTTTGTGGAGTTGGGGTCTCACTATGTTGCCCAGGTTGGCCTCGAGCTCCTGGGCTCAAGTGATCCTCTGCCCTCAGCCTCCTAAAATGCTGGGATTACAGCCTGAGCTAAATCTTAAATGACCAGGAAGTGCGTGCTGAGCAGGCAGAGGATGGGGGGATGGAGCTGGAGAAGAGGGAGGGGAGGGGCTTGAGATGGGGGTGGGGGGTGGGGGCTGGGGGGTAGGGGGGTGGCGGGGGCACCTAAAACCCAGGCACAGGGAATAGCATGACTCAGAGGACACTCAGTGTGACCAGAGGAGCGTGTGGGCAGGGTCACTTGGCACTTTAAAGTCAGGCAGAAGAATTCAGGGTCTCCTGTGCTTCACCATGGGGCGGGGGGCATCATCAGAGGGGCAGCTGCCTGGAGAAGGTTTTACTTTTTGAGACCGAGTCTTCCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGGTCTCGGCTCACTGTAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTGAGCTTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAAATTTTGTATTTTTTGTGGAGGCAGGGTTATGCCATGTTGGCCAGGCTGGTTTTGAACTCCTGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGGCCTCCCAAAGTGCTGGGATTACAGGTGTCAGCCACTGTGCCCAGCCTAGAATGTTTTAGAGGAGTCCACGCAGGAGGCTGAAGAAACAGCCCAGGTGACAGACGGACACTGGGACAGCTGGGCCAAGAGAGGAAATAAGTTCCTTCCCTCCATCCCCCATCTCTCCCTCTCTCTTTCCCGCCTTTTCTTTCCTTCCTTCCCTATCTCCTTTCTTCCTCTTTCCTTTGCTTTCTTCCCTCTTTCCTTTTATTTCCTTCCCTCCCTCCCCCCTTTCTTCCTTCTCTCCCTCATTCCTTCTCTTCCGCCCTCAATTCTTTCCTTCCCTCCTTCCCTCTGTCCTTCCTCCCCTTTCCTATCTTTCCTTCCCTCCCTCCTTTTCTCTCCTTCCCCTCCCTCCTTCCTCTCCTCCTTTCCTTCTTCCCTCCCTCCTTTCTTCCATAGTTCACAAACACTTACTGAGAACCTTCTGCCTGCCAAGCACTAACTAGATGCCGAGTTGGCCACAATCAGTGGCCTGTGCTGTTGCAAAGCTTCCAGTTAAGGAAAACAAGGCAATCAACCCTGCCGGGTGCTTCCTGTAGGACCCTGTAGGTTGTGGGAAGTGCTGTGGGGGGAAAAAAGCAAAAACAATCCCAGGGCAGGCAAAGGAGAGGCTGCTGCTGGGAGGGGAGGGATGGACGTGCCATTTCCTTGCTGGAGGGTGGTGAGGGAAGCCGCCCTGACTGCAGGGAGGTGACAGAGGATCTTCGGGAGTGAGGGTGATCCAGGTGGAGGGAACAGCTAAAGCGAAGGCCTGCAGGGATGTGTGAGATCGGGCAGGTTTGAGGATGGGAGATGTGTGGGGAAAGGCAGGGAAGGAGGGGAGATGGGTAGAAGGTGAGGTTGGAAGCAATAAGGCCAGCTCAGGGCGGGCCTGGTGGGCCACTGTGGGGTCTTTGGCTCAGTCTGAGGAAAATGGGGCCG
CTGTGGTCCCAGCTACTTGGCAGGCTGGGGCAGGAGAATCACTTGAATCTGCGAGGTAGATCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAATAAATAAATAAAAATAAAAAATAAAAAACATGGAGATGGCTCAGGTATGCCGCCGTTTCTTGTTTTCACCATGCTGAAAGGACTAGAGATAGCAAAGGAAGAGAAACAAAATCGCTTTGTATAAAAAAGGGAACTGACATGATTGCTTGTATGTGGAATTGCTGGGCAGATGGACAAGTATGCATGTTCTGAGGTGTGTGTGGAAAGGTCTGCACATTGCCCTCCAAAGGCTGACCCCTTCCAGATGTATTTGCTGTACTCTCTGCCCGCCTCTGTTCTTGCCCCTACCCGCCTCTTTTCCAGCTCCACACCATCCCTCTCCCTCCCACTCTGTCTTCCCTCTCCTCTGCAAATGGCAGGGGTAGGGAAGCTGGAGCCAGGTGTAGCCCACGCACTCTCCCAGGATGGCTCCAGCCCTTGCACCCACCTCACCTGGACGAGGGAGTGGATGGAGAAGGGCAGGAAAGCCTGGGCCTTGTTGAGGATGTTGAGAACTGTGAGAGTCACAAAGGCTTTCTCTGCATTCATAGCATTCTCGGCCACCAGAGTGTGGACAGCAAACACCACCAGTGCGACCTGGGGGGTGGGGGGGACACGTGGGGCAACAGTGAGACACGCAAGCATGGATAGGGCAGCCTGGGCAAGCTGTGGTGCCTGCACGGTCCATGTGGCCCACCCGCCATGTCCGCATGTGCTTCCCTCCGTAGATCCCACTCCCAGTCCTGCTAACACATGTCCTCTCCGCAGTCATAAGCTACATAAGGCTCTCTCTAAAGACACAGCGCATTGCTAATGGTGATGAGTGCGCAGCCCCACGGCTCTAGGCATCACTAGAACCTAGGGGAGAACCTAATGCCTCTAGGTTCCAGGCATCGGGGGACAGCAGAGTTTTTGATCTTGGTAGCCCTGTTGTTCTAGACGTGGTGGAACTTGTGATTCTAGAGTCCCTTGGAAGATGACTCTAAAGTTGCAGGCAGGAGCAGCACTTGAGGGCTCTAGGTGTTGGTGCCATTTGTGGTGCTTTTTTTTTTTTTTTTGAGATGAAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGCATGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGACTCCCAAGTAGCTGGGATTACAGGCGCCCGCCACTGCAACCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTATTGGGACGACAGGCATGAGCCACCACACCCAGCCTACGTATCAAATTTTTTAAAACTGTGGTTTAGGAAGGTTGTTCTGACAGCAATATGAAATAAATTACAGAATGGCAGGACAAGGATCACGTCCAGTGACAGGGTGGCTATGGACATCTGCTGGCCAGGATCAGGGAAGTCACTCTGACCCAGGATTCTACCTCTGCCACCCCCCTGCATCTGTACCCTCCTCCCCACATCGGTAGAAGCCTGGAACTCTCTCTGAGAGTTCAGCAGACTTTATCAGCCACTGCCACCTTTGCTAGAATAATATGATTAATTAGTTCTTGTAGAAGACAGCAGGGACCCAGAGAGAACAGGATCCAGAATGAGTGGGTTTTGATGGACGGGGTGGTAGGATCTGGGGGGCTCCACCTACCTCACCCTGCCCCCACCCCCGCACTCCTTCCCCAGTGCTGCTCAGCATAGAGACTAGAGTGACGTCACCAGAAATGTAGACACTTGGAAGGACACCAGCGACACAGAGAAGAGGAGGCCGGAGGTCCGCAAGGCGCCCAGCTCCTGGCCTCGGATGCCCAGGACTCTGTCCAGAAAGGCTCCCTCCCAGCCATGGAACTTGATGGTCTTCGAGTTCCTGTGGATAGAGCTGGTGAGCCGTGCCCGTGAGTCCTTCTGCCTCATTTGCTCCTCCTGGGATCGGAGGGAAAAAGAGAGATGAAGACAGGGACAGTTGAGAACTCTTCCCTGCACCCTGACAGCCACCCTTCAGCAAATCCCATTCATCTCACCAAACTGCGTCCCAAACCTGTCTGCCTCTCAGCACCTCTGACCCTCACTCCTGGTCCAACCACCATCATCCTGTACCTGGACTTCTGCAGGAGTGCCCCTGGGATAATGTGCCCCATGGAGGAAGCCTCTGATGCCCGGAGAACAGAGGCAGCCTGAGCCCACCTGGGTATGACACCATCAGGAAGGCTACCTGGAGGTGGTTGATGCCTGAGCTACGTCTTTTTTTTTTTTTACCTTTTACATTTTTTGTGGAGTTGGGGTCTCACTATGTTGCCCAGGTTGGCCTCGAGCTCCTGGGCTCAAGTGATCCTCTGCCCTCAGCCTCCTAAAATGCTGGGATTACAGCCTGAGCTAAATCTTAAATGACCAGGAAGTGCGTGCTGAGCAGGCAGAGGATGGGGGGATGGAGCTGGAGAAGAGGGAGGGGAGGGGCTTGAGATGGGGGTGGGGGGTGGGGGCTGGGGGGTAGGGGGGTGGCGGGGGCACCTAAAACCCAGGCACAGGGAATAGCATGACTCAGAGGACACTCAGTGTGACCAGAGGAGCGTGTGGGCAGGGTCACTTGGCACTTTAAAGTCAGGCAGAAGAATTCAGGGTCTCCTGTGCTTCACCATGGGGCGGGGGGCATCATCAGAGGGGCAGCTGCCTGGAGAAGGTTTTACTTTTTGAGACCGAGTCTTCCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGGTCTCGGCTCACTGTAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTGAGCTTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAAATTTTGTATTTTTTGTGGAGGCAGGGTTATGCCATGTTGGCCAGGCTGGTTTTGAACTCCTGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGGCCTCCCAAAGTGCTGGGATTACAGGTGTCAGCCACTGTGCCCAGCCTAGAATGTTTTAGAGGAGTCCACGCAGGAGGCTGAAGAAACAGCCCAGGTGACAGACGGACACTGGGACAGCTGGGCCAAGAGAGGAAATAAGTTCCTTCCCTCCATCCCCCATCTCTCCCTCTCTCTTTCCCGCCTTTTCTTTCCTTCCTTCCCTATCTCCTTTCTTCCTCTTTCCTTTGCTTTCTTCCCTCTTTCCTTTTATTTCCTTCCCTCCCTCCCCCCTTTCTTCCTTCTCTCCCTCATTCCTTCTCTTCCGCCCTCAATTCTTTCCTTCCCTCCTTCCCTCTGTCCTTCCTCCCCTTTCCTATCTTTCCTTCCCTCCCTCCTTTTCTCTCCTTCCCCTCCCTCCTTCCTCTCCTCCTTTCCTTCTTCCCTCCCTCCTTTCTTCCATAGTTCACAAACACTTACTGAGAACCTTCTGCCTGCCAAGCACTAACTAGATGCCGAGTTGGCCACAATCAGTGGCCTGTGCTGTTGCAAAGCTTCCAGTTAAGGAAAACAAGGCAATCAACCCTGCCGGGTGCTTCCTGTAGGACCCTGTAGGTTGTGGGAAGTGCTGTGGGGGGAAAAAAGCAAAAACAATCCCAGGGCAGGCAAAGGAGAGGCTGCTGCTGGGAGGGGAGGGATGGACGTGCCATTTCCTTGCTGGAGGGTGGTGAGGGAAGCCGCCCTGACTGCAGGGAGGTGACAGAGGATCTTCGGGAGTGAGGGTGATCCAGGTGGAGGGAACAGCTAAAGCGAAGGCCTGCAGGGATGTGTGAGATCGGGCAGGTTTGAGGATGGGAGATGTGTGGGGAAAGGCAGGGAAGGAGGGGAGATGGGTAGAAGGTGAGGTTGGAAGCAATAAGGCCAGCTCAGGGCGGGCCTGGTGGGCCACTGTGGGGTCTTTGGCTCAGTCTGAGGAAAATGGGGCCG
Task1_train_22431
Here is a genetic alteration in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
ATAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAAGTTGTGCCATTGCACCAAAGCCTGGGCAACACAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAATCAAAAGGATACTATTTCACGACATATGAAAATGATATGCACTTCAAATGTCAGCATCCATAAATAGAGTTTTATTGGAGGAATACCATGCCTGTTTGCTTAGTATGGTCTACAGCCACTTCTGCACTCCAAGGGCAGAGATGAATATTTGCAGGAGAGATGGTGTGGCCTCCAGTGTAAAAAGCATCTACTGTCTTATCCTTTATGGAAAAGTAACTAATGATAATATTACAAATACCTACAGGGTGCAGTTGTGTGCCCGGCACCCTTTTAAGTGCTTTCTACATATGGGCTCGTTTAATGCCTCAGCCCCTCTGGGGCAGGAGTGCTACTGTTAATTATGATCCTCACGTTGGAGACAAGAACAGGAGGCACAGAGAGAGTAGGGTCCTTGCACACAGATTCACAACTGATAAGTGGTCAGAAGGAGGATTTGAGCCTAGGCAGTTCCCGATACAGAGTCTAATTTTATTTTTACTTTTATTTATTTGTTGGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATTATCTCAGCTCACTGCAACTTCCACCTCCAAGGCTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTGGATGGGGTTATAGGCACCCACCACTATGCCCGGCTAATTTTTGTATCTTTCAGTAGAGACGGGGTTGGCCAGGCTGGTCTGGAACTCCTGGCCTCAAGTGATCCACCTACCTCACCCCCCAAATTGCTGAGATTATAGGCATGAGCCACTGTGCCTGGCCCAGAGTCTGATTTTAATTTAAAAAAAGAAAATCCTATACCACAACGTTAAAGGAATGAAGTTGGAAAGTAAATGTTTTGTTTGTTTTGTTTGGTTGTTTCCTGATGGCTACTTTGTGTTTTTTGAACACTAAGTAGCAATTTTTCCCCCTAAAATGTTCTCCTCTTGTGTTTTGTGGACAGTGGCTATGGTGGTGCCTCAGGGTTACTGGTAACTTCAAAACATGGTTAACTTGCCTACTGGGTACCCTAATAGCACATGGGGAAGTATCAACGTCATCATCATCATCTTTCTACAGAGGAAACTGAGGCCCAGAGAGGGTGAACTTCCTGCCCAAGGTCAAGTGAAGGTCATCCTTATTGAGGACTTTTCCCATCGTATCAGACAATAGTAGGCAAATTGAGACAGGATTGGAGGAGGAGGAGAAGGAGGAGATGGGGGTGGAAGGGGAGGAGAAAAAGGAGGAGAGGAAGAAGAAAGGGAAGAGAAGGAGAGGGAAGAGCAGAGGGAAGAGAGGGAGGACGGTAGAGGAGAAGAAGGGAGAAGGGAAGAAGTGGGAGGGAAGATGACAGGGAGCAGAAAGGAAGAAGAAGGTGGAGCAGGAGAGAGGAAGAGGAGGAGGAGGGGGAAGGAGGAAAAGGAAGGGGTGCAGGAAGAGGAGGGGGTGCGTGGGCAGAAGGTGGGAGAGATGCAGGAGGAGGGAGGGTGCAGGGAGGGGTGCAAGAGGAGGGGGGCAGGAGGAGGAGGCTGGGGCAGAGGGAGAGGGGAGGAAGCCTTATGAGCTTCTACACCAGGAATGGAATCCAGGGTGATGAAGGCAGAACAAGGGTAAAACCTTTCATGTGCCTCTCTGACACCAACCTGGTTCTCCCACAGCCTCAGACTTGCCCTAACCCTGGGGTCACAGCGGACCTCTTCCAGCCTCTTGAATGCTAAGTCAGGAGGAGGAAGGGTGGGAGGGGGAAGGAGGAGGGGGAGAAGGAGGGGGTGGGGGACTCCGTTCAAATCCCGTCTTCCTCCTCTGGCATACCTGCCAGAGATAGACGAAGCAGACCACGATCCAGACGAGAGGCAGCCACAGCCCGTTGAGGTAGAGGACGCTCTCGGTCAGCCGCTGCACGTCCACGGACACCAGATTGACCACATCACCCACCGCACTGGCCTTTCTGGAGCCGCTGGACAGAGCCAGGACCTGGCGGGTGGGCAGAAGGAGAGAAGTAAAGTGGGGAGGCCGGGGCAGAGGGATGCCCCAGGTGGCTTCTCCACCCACTGAGCCCCACCTCACACGTCTGCGAGGTGGGTGAGTAAAGTCTCTTAGGCCAACCTCTCAGGGCTCTTTGAGGATCCACAGAGATGACAAAAATGAAAATCCTCCAAGATCCCTAAAGCACGGGAGGCATAATAATGAATAACATGCACGAAAACACCAGATTAACACAGATAACGGTGGTCATCTGCCCAGTGCTCACCATGTCGCAGGCACTGTGCTAAATGAACAGCCTTATCCTTTCCCGGGGTGCTCACAGCCATGAATGGTACCAAGCAGGCACTACCATATTCATTCCCTCTAATGCCAGGCCAGGTGCAGTGGCCTCTGCCTGTAATCCCGCCACTCTGGGAGGCTGAGGTGGGAGGATTGCTTGATCCCAGGAGTTCGAAACCAGCCCGCGCGACATAGTAAGACCCAAGCTCTACAAAATACTTTAAAAAATTAGCCAGGGGGCCGGGTGCGGTGCCTCACGTCTATAATCCCAGCACTTTGGGAGGCCGAGGTGGACAGATCACCTGAGGTCAGGAGGTGGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACCAAAAATACAAAAATTAGCTGGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATCGCTTAAACCCAGGAGGCAGAGGTTGCAGTGAGCCCAGATCAAGCCATTGCATTCCAGTCTGGGCAACAAGAGCAAAATCCATTTCGGGGGGGAAAAAAGAAAAAATTAGCCAGGCATGGTTGTGGTGCGCCTGTGGTCCTAGCTAGCTACTGGGGAGGCTGAGGTGGGAGGATTAATTGAGTACAGGAGGTTGAGGCTGCAGTGAGCCATGTTGGTGCCACTGCACTCTAGCCTGGGCAACAGAGCAAGACCCTGTCTTTAAAAAAAATTCTATGGATAAATTGCTCTCTATTATTCTCTCACCAAGGAAAATACCACTTCCAGTTAAATTAAGACATGTAAGAGACATCTCGATTTTGGAAGTATTAGAGTGAAAAAAAAATGTGAGACGAGAATCAATGAAATGAACATTTACTAACCCCATTCTATGGCTAAAGAAACTGAGGCAGAGAGAAGTTGAGCAACTTGCCCAAAGTCACAGGCCTTGTAAGCTCCTACACAAGGAATGGAATCCAGGGTGACGAAGGCATGACAAGGGTGAGACCTTTCATGTGCTTCTGTGACACCAACCTGGTTCTCTGGCAGCCTCACATCTGCCTTAACCCTGGGGTCACAGTGGACCTCTTCCAGCCTGTTGAATGCTAAATTCCAAATGCAGCCCTCCCTTTGTGACTGCGTGAGGGTGTGAAGAAGTGATCCAGGAATGACTGGACATAGAAATTCTCCACTTAGCAAGTCTTTGAAGAGTGCTCACTGTGTGACTCACACTGAGCTGGGAACTGAAAATACAGCTGTGAACAACAGAGATGAGGCTTGCTCTCCCGGGCCTGGAGTTTGAGGTGGGGAACAAGGCTCTATAATAAAGATTTATATAACTGGCCGGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATTGCTTGAGGCCGGGAGTTCGAGATCAGCCTGGCCAATATGGCAAAACCCCATCTCTAGTAAAAATACAAAAATTAACTGGGCATGCTGGTGGGCACCTGTAATCCCAGCTATTTGGGAGGGTGAGGCAGGACAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCACCGCTGCACTACAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAATAAGACAAAACAAAAATATTTCTAAAACTCATGCTTTAATGGCAGTTATGATGAGTAACATAAAAAAGTAGCCCAGGCTGAGCGCGTTGGCTCATGTCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACC
ATAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAAGTTGTGCCATTGCACCAAAGCCTGGGCAACACAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAATCAAAAGGATACTATTTCACGACATATGAAAATGATATGCACTTCAAATGTCAGCATCCATAAATAGAGTTTTATTGGAGGAATACCATGCCTGTTTGCTTAGTATGGTCTACAGCCACTTCTGCACTCCAAGGGCAGAGATGAATATTTGCAGGAGAGATGGTGTGGCCTCCAGTGTAAAAAGCATCTACTGTCTTATCCTTTATGGAAAAGTAACTAATGATAATATTACAAATACCTACAGGGTGCAGTTGTGTGCCCGGCACCCTTTTAAGTGCTTTCTACATATGGGCTCGTTTAATGCCTCAGCCCCTCTGGGGCAGGAGTGCTACTGTTAATTATGATCCTCACGTTGGAGACAAGAACAGGAGGCACAGAGAGAGTAGGGTCCTTGCACACAGATTCACAACTGATAAGTGGTCAGAAGGAGGATTTGAGCCTAGGCAGTTCCCGATACAGAGTCTAATTTTATTTTTACTTTTATTTATTTGTTGGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATTATCTCAGCTCACTGCAACTTCCACCTCCAAGGCTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTGGATGGGGTTATAGGCACCCACCACTATGCCCGGCTAATTTTTGTATCTTTCAGTAGAGACGGGGTTGGCCAGGCTGGTCTGGAACTCCTGGCCTCAAGTGATCCACCTACCTCACCCCCCAAATTGCTGAGATTATAGGCATGAGCCACTGTGCCTGGCCCAGAGTCTGATTTTAATTTAAAAAAAGAAAATCCTATACCACAACGTTAAAGGAATGAAGTTGGAAAGTAAATGTTTTGTTTGTTTTGTTTGGTTGTTTCCTGATGGCTACTTTGTGTTTTTTGAACACTAAGTAGCAATTTTTCCCCCTAAAATGTTCTCCTCTTGTGTTTTGTGGACAGTGGCTATGGTGGTGCCTCAGGGTTACTGGTAACTTCAAAACATGGTTAACTTGCCTACTGGGTACCCTAATAGCACATGGGGAAGTATCAACGTCATCATCATCATCTTTCTACAGAGGAAACTGAGGCCCAGAGAGGGTGAACTTCCTGCCCAAGGTCAAGTGAAGGTCATCCTTATTGAGGACTTTTCCCATCGTATCAGACAATAGTAGGCAAATTGAGACAGGATTGGAGGAGGAGGAGAAGGAGGAGATGGGGGTGGAAGGGGAGGAGAAAAAGGAGGAGAGGAAGAAGAAAGGGAAGAGAAGGAGAGGGAAGAGCAGAGGGAAGAGAGGGAGGACGGTAGAGGAGAAGAAGGGAGAAGGGAAGAAGTGGGAGGGAAGATGACAGGGAGCAGAAAGGAAGAAGAAGGTGGAGCAGGAGAGAGGAAGAGGAGGAGGAGGGGGAAGGAGGAAAAGGAAGGGGTGCAGGAAGAGGAGGGGGTGCGTGGGCAGAAGGTGGGAGAGATGCAGGAGGAGGGAGGGTGCAGGGAGGGGTGCAAGAGGAGGGGGGCAGGAGGAGGAGGCTGGGGCAGAGGGAGAGGGGAGGAAGCCTTATGAGCTTCTACACCAGGAATGGAATCCAGGGTGATGAAGGCAGAACAAGGGTAAAACCTTTCATGTGCCTCTCTGACACCAACCTGGTTCTCCCACAGCCTCAGACTTGCCCTAACCCTGGGGTCACAGCGGACCTCTTCCAGCCTCTTGAATGCTAAGTCAGGAGGAGGAAGGGTGGGAGGGGGAAGGAGGAGGGGGAGAAGGAGGGGGTGGGGGACTCCGTTCAAATCCCGTCTTCCTCCTCTGGCATACCTGCCAGAGATAGACGAAGCAGACCACGATCCAGACGAGAGGCAGCCACAGCCCGTTGAGGTAGAGGACGCTCTCGGTCAGCCGCTGCACGTCCACGGACACCAGATTGACCACATCACCCACCGCACTGGCCTTTCTGGAGCCGCCGGACAGAGCCAGGACCTGGCGGGTGGGCAGAAGGAGAGAAGTAAAGTGGGGAGGCCGGGGCAGAGGGATGCCCCAGGTGGCTTCTCCACCCACTGAGCCCCACCTCACACGTCTGCGAGGTGGGTGAGTAAAGTCTCTTAGGCCAACCTCTCAGGGCTCTTTGAGGATCCACAGAGATGACAAAAATGAAAATCCTCCAAGATCCCTAAAGCACGGGAGGCATAATAATGAATAACATGCACGAAAACACCAGATTAACACAGATAACGGTGGTCATCTGCCCAGTGCTCACCATGTCGCAGGCACTGTGCTAAATGAACAGCCTTATCCTTTCCCGGGGTGCTCACAGCCATGAATGGTACCAAGCAGGCACTACCATATTCATTCCCTCTAATGCCAGGCCAGGTGCAGTGGCCTCTGCCTGTAATCCCGCCACTCTGGGAGGCTGAGGTGGGAGGATTGCTTGATCCCAGGAGTTCGAAACCAGCCCGCGCGACATAGTAAGACCCAAGCTCTACAAAATACTTTAAAAAATTAGCCAGGGGGCCGGGTGCGGTGCCTCACGTCTATAATCCCAGCACTTTGGGAGGCCGAGGTGGACAGATCACCTGAGGTCAGGAGGTGGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACCAAAAATACAAAAATTAGCTGGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATCGCTTAAACCCAGGAGGCAGAGGTTGCAGTGAGCCCAGATCAAGCCATTGCATTCCAGTCTGGGCAACAAGAGCAAAATCCATTTCGGGGGGGAAAAAAGAAAAAATTAGCCAGGCATGGTTGTGGTGCGCCTGTGGTCCTAGCTAGCTACTGGGGAGGCTGAGGTGGGAGGATTAATTGAGTACAGGAGGTTGAGGCTGCAGTGAGCCATGTTGGTGCCACTGCACTCTAGCCTGGGCAACAGAGCAAGACCCTGTCTTTAAAAAAAATTCTATGGATAAATTGCTCTCTATTATTCTCTCACCAAGGAAAATACCACTTCCAGTTAAATTAAGACATGTAAGAGACATCTCGATTTTGGAAGTATTAGAGTGAAAAAAAAATGTGAGACGAGAATCAATGAAATGAACATTTACTAACCCCATTCTATGGCTAAAGAAACTGAGGCAGAGAGAAGTTGAGCAACTTGCCCAAAGTCACAGGCCTTGTAAGCTCCTACACAAGGAATGGAATCCAGGGTGACGAAGGCATGACAAGGGTGAGACCTTTCATGTGCTTCTGTGACACCAACCTGGTTCTCTGGCAGCCTCACATCTGCCTTAACCCTGGGGTCACAGTGGACCTCTTCCAGCCTGTTGAATGCTAAATTCCAAATGCAGCCCTCCCTTTGTGACTGCGTGAGGGTGTGAAGAAGTGATCCAGGAATGACTGGACATAGAAATTCTCCACTTAGCAAGTCTTTGAAGAGTGCTCACTGTGTGACTCACACTGAGCTGGGAACTGAAAATACAGCTGTGAACAACAGAGATGAGGCTTGCTCTCCCGGGCCTGGAGTTTGAGGTGGGGAACAAGGCTCTATAATAAAGATTTATATAACTGGCCGGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATTGCTTGAGGCCGGGAGTTCGAGATCAGCCTGGCCAATATGGCAAAACCCCATCTCTAGTAAAAATACAAAAATTAACTGGGCATGCTGGTGGGCACCTGTAATCCCAGCTATTTGGGAGGGTGAGGCAGGACAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCACCGCTGCACTACAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAATAAGACAAAACAAAAATATTTCTAAAACTCATGCTTTAATGGCAGTTATGATGAGTAACATAAAAAAGTAGCCCAGGCTGAGCGCGTTGGCTCATGTCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACC
Task1_train_22432
Gene ABCC6 (ATP binding cassette subfamily C member 6), found on Chromosome 16, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
AGAAGTGGTGCCTAGACAGTGAGAACAGCTGCAAAGGCCCCAGGGTGGGTGGGGGCCTGGAGTGTTTGAGGAACTGAAAGGAGACCTGTGTGGCTGGAGGAGAGTGAGCATGGGAGGAGGTGACGGGATGAGGTCAGAGACACCCTAGGGACAGATCACACAAGACCTTACAGGAATAACTAAGGAGCTGAGACAGATCACTTGAGGCTAGGAGTTCGAGACCAGCCTGACCAACATGGCAAAACCTTGTCTCTACCAAAAATATAAAAATTAGCTGGGCGTGGTGACACGTGTCTATAGTCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAATAAATACATATAATACAGAGAAATAACTAAGGAAGTGAGAATGTATGGTGAGTGACTCTAATAAGCAAGGACTGAATGCGTTCTCAGCTGCTGATAACATTACTGCCCGCTCAGTGATACTGCTTTTCCTGGCTGGGAAGACCTGCCCTTGTCCCCCAGGGCTCACCTTTCTGTACACCAGGCCAGTGATGGCCGACCGCAACCTCATCTGCAGCACCTTGAGCCTGTACATGTTCTGCTGCTCAAACAGCGTTTGCAGGCAGGCTGAGAGGAACATCAGCACGGCGAGGAGGTAGCCCTTCCAGGCTGGAGGCTTGGGATCACCAATAAACTCCAGGAAAAGGCTTGCAGGGGAAGGAGGGAGAAGGTACAGCTGGTGAGAGGAGGTGCCTAAGGGTGTTGCCTTTGCCCAAACCAGTCCAGATGTGGAGGATCAGTCGGCCCAAACTAGTCCAGGTGTGGAGGATCAGTCAGTGTGGTTTTTTTTGCAATAATGGTCTCCGTTATTTCCCCCACTGTCCATACTCCTTTTCAATCTGACTGCAGCTCCTCAAGATCAAGAGGTGGAGTTTTTGTTCCCACTTGTTATAGGCTAAATTGTGTCCTCACAAAGTTTATATGTTGAAGCCCCGACCCCCAGTACCTCTGAATGTGACTGTATTTGGAAATAGGGCCTTTAAAGAGGCAATGAAGTTAAAAATGAGGTCATTAGGCTGGGCCCTAATCCAATCTGATGGGGTCCTTTTAAGAAGAGGAAATGTAGACACACAAGGAGACACCAGGGGGCGCAAACAGAGGAAAGACCATATGGGGACACAGGGAGGAGGTGGCCAACTGCAAGCCAAGGACAGAGGCCTCAGATGGAACCACCTTGCAGATACTAATCTCGAACTTCCAGCTTTGAGAATCATGATAAAATACATTTCTGTTGTTCAAGCCACTCAGTCTCAGTCTGTGATGCTTTGTTATGTCAGCTGAGCAGACACCACTTGAATCTGGGCTGGCTACAAAACCGGCTTTGGCCAACAGAGTACAGTGGAGGTAAAGCCATGCTGGCTCTGAGCCTAGGCCTCAAGAGAAAATGTGGTTTTTGGTCTATTTCTTAGAACCCTCCCAAGCACCCACATGAACAAGTCTGAGCTAGCCTTTTGGAGGATGGGGACCCACATGGAGCAGAGACAGCCATCCCAGTCTCAGATACACAACTGCAGGCACATGAGAAAACCCAGCCAAGAAAAGAACCACCACCCAGCTGAGCCCAGCCCACATTACTGACCCACATTACCATGAACTAAATAAAAGAATGTTTGTCATTTTAAGCCACTCACTTTTGGGGCATTTTACAGCAAAAACTAATTGATGCAGTCAGGTAAGAGCTTGCTTATTTGCCCTTCTGGGGGTCAGTCACTTTCTCATTAATCCATTTCCCTTCCTCAGTGTCCTTCTCACCCACCATCCAGTGTCCCGAGCACCAGACGTATAGGCAGAGGCAGGAGAGCTGAAGCCCCCTGGCCCTGGAAGGATGCCACTAAGAGACCACCCACCTTAGCAGGGCACTTGAGGTCTGGGACTCACCTGAGCAGCTTGGGGACAGTGAACCTGAAGACATCACTGATGATGAGGCTGAGGGTCCCCAGGAGGAAGGTAGAATGGAACACCTGCCAGATGGCCTTCAGCAGTGGGCGCCACTGGCTCCCTTCTTGCCGTAGGAAGGGCTCGGTCTCTGGAGCCTTCATGCCACTGCCGCCTTTCCTTTTAAATGCTATTGCCTTGTTGTGCCTGAGGGGAAGGGAGAGATTAGCTCTGGGTCCCATTTTATACTCTCAGCCGCCAGCGGCAGGGCCAGGCATTAAAGGGTTGTTTTCCCAACAGTGGAGATGGGTGGGTGTGGATCTAGCCTGGCTCCCTCACCTGTTCCTCCTTATCACCCTGAGTACCCACTTAAGAGGCAATCATGGGAGTTGGGGGGCAGGGCAGGAGGGCACTCTGAGGCCTCTTAGATGGCCATGGGAAAGCACACCTGTTGAGCACCTACTATGTGCCAGGCACTCCCCAGTCATCCTAAGACCCCCTGAGAAGCCAGGTGTTGTTCCCATTTCACAGATGAGAAAACTGGGGCTCAGAGAAGCGAACTTGCCCAAGGGCACACAGCTGAGAAGTAAAAGAACTGGAATTTGATTCCAGCTCTCTGCCTCCAGAGCCCATGCACTTTTCTTTTTTCTTTTCCTTTTTTTTTTTTTGAGACGAAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACGGCAACCTCCACTTCCCAGTTCAAGTGATTGTCCCACCTCAGCCTCTCGAGTAGCTGGGATTACAGGCAAGTGCCACCATACCCAGCTAATTTTTGTATTTTCAGTAGAGAAGGGGTTATGCCATGTTGGCCAGGTTGGTTTTGAACTCCTGACCTGAGGTGATCTGCTCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGATGTGAGCCACCACACCTGGCCTCTCATGTACTTTTCAACCTATCGTGTTGTCAACCTGGAGGAAGAACAGCACCCCGTCCCCAACACACACAATCAGCCAGCCCTTAGGTGGTTTTGAACTGGTGGAGAATCACGGCTGATGGGCATGGGGCCTGGTGCTCTAGCTCTGGGTGAAAGTGCAGACAGAAGCTCAGGCTGCCTCAAACTAATAAGATCCCCAGCCTTTGGCTATAACCAGGGGCCACAGAGAAGAGCTAAGGTGAGGGAGGGAGAGGAGGAGATGGGGGAGGCCCGAGGGCCCCTGTGAGGCAGGTCAGAAGCCCTGGGCCAGAAAGGAGAGGCTGGGGCGATGCAGCTGCTGACAGTCCGGTTGCTGTGTGGTCCTGGGCGGGGACACTGCTCCTCTCTCTGTGTGTGAGAGGATGGGTGTGGTCCCCTGCTGAGTCCCCTGTGGCTCTGACAACCTATAAGGTTATCAGTAATTTCTTTTTCTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGTCGCCCAGGCTGGAGTGCAGTGTAGCAATCTCGGCTCACCGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACACACCACCATGCCTGGCTAATTTTTGTATTTTTGGTAGAGACAGGGTTTCACAACGTTAGCCAGGCTGGTCTTAAACTCCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCCCGGCCACTTATCAGTAATTTCAATCCCCATTACAGATCTGTGACCCGGGGCCACGTGCTGGGATCAGCTCTTTACACGAAGGAGCTCACTGACTCCCCTGGATCCCCTTGCCAGGTGAGCATTATTAGGTTTTCCATTTTACAGAAGGGGAAGCTGAGGCTCTGAGAGATGGCGACAGCCGCCCGAGGTCACACAGCAAGGGCAGAGCAGGGATTTGAGCCTAGATCTTGATTTATGGTTTGTAAAGGGTTTCTTGTGCACTAAGGACCCCCAACCTCACCATAATAAAATAATAATAAAAAAAGAAGCATAAGAAAAACCTCTGGTGAGCTCAGGTGGCCAGACCCTTCAAGGCCAAGGTCTCTGTCCCACAT
AGAAGTGGTGCCTAGACAGTGAGAACAGCTGCAAAGGCCCCAGGGTGGGTGGGGGCCTGGAGTGTTTGAGGAACTGAAAGGAGACCTGTGTGGCTGGAGGAGAGTGAGCATGGGAGGAGGTGACGGGATGAGGTCAGAGACACCCTAGGGACAGATCACACAAGACCTTACAGGAATAACTAAGGAGCTGAGACAGATCACTTGAGGCTAGGAGTTCGAGACCAGCCTGACCAACATGGCAAAACCTTGTCTCTACCAAAAATATAAAAATTAGCTGGGCGTGGTGACACGTGTCTATAGTCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAATAAATACATATAATACAGAGAAATAACTAAGGAAGTGAGAATGTATGGTGAGTGACTCTAATAAGCAAGGACTGAATGCGTTCTCAGCTGCTGATAACATTACTGCCCGCTCAGTGATACTGCTTTTCCTGGCTGGGAAGACCTGCCCTTGTCCCCCAGGGCTCACCTTTCTGTACACCAGGCCAGTGATGGCCGACCGCAACCTCATCTGCAGCACCTTGAGCCTGTACATGTTCTGCTGCTCAAACAGCGTTTGCAGGCAGGCTGAGAGGAACATCAGCACGGCGAGGAGGTAGCCCTTCCAGGCTGGAGGCTTGGGATCACCAATAAACTCCAGGAAAAGGCTTGCAGGGGAAGGAGGGAGAAGGTACAGCTGGTGAGAGGAGGTGCCTAAGGGTGTTGCCTTTGCCCAAACCAGTCCAGATGTGGAGGATCAGTCGGCCCAAACTAGTCCAGGTGTGGAGGATCAGTCAGTGTGGTTTTTTTTGCAATAATGGTCTCCGTTATTTCCCCCACTGTCCATACTCCTTTTCAATCTGACTGCAGCTCCTCAAGATCAAGAGGTGGAGTTTTTGTTCCCACTTGTTATAGGCTAAATTGTGTCCTCACAAAGTTTATATGTTGAAGCCCCGACCCCCAGTACCTCTGAATGTGACTGTATTTGGAAATAGGGCCTTTAAAGAGGCAATGAAGTTAAAAATGAGGTCATTAGGCTGGGCCCTAATCCAATCTGATGGGGTCCTTTTAAGAAGAGGAAATGTAGACACACAAGGAGACACCAGGGGGCGCAAACAGAGGAAAGACCATATGGGGACACAGGGAGGAGGTGGCCAACTGCAAGCCAAGGACAGAGGCCTCAGATGGAACCACCTTGCAGATACTAATCTCGAACTTCCAGCTTTGAGAATCATGATAAAATACATTTCTGTTGTTCAAGCCACTCAGTCTCAGTCTGTGATGCTTTGTTATGTCAGCTGAGCAGACACCACTTGAATCTGGGCTGGCTACAAAACCGGCTTTGGCCAACAGAGTACAGTGGAGGTAAAGCCATGCTGGCTCTGAGCCTAGGCCTCAAGAGAAAATGTGGTTTTTGGTCTATTTCTTAGAACCCTCCCAAGCACCCACATGAACAAGTCTGAGCTAGCCTTTTGGAGGATGGGGACCCACATGGAGCAGAGACAGCCATCCCAGTCTCAGATACACAACTGCAGGCACATGAGAAAACCCAGCCAAGAAAAGAACCACCACCCAGCTGAGCCCAGCCCACATTACTGACCCACATTACCATGAACTAAATAAAAGAATGTTTGTCATTTTAAGCCACTCACTTTTGGGGCATTTTACAGCAAAAACTAATTGATGCAGTCAGGTAAGAGCTTGCTTATTTGCCCTTCTGGGGGTCAGTCACTTTCTCATTAATCCATTTCCCTTCCTCAGTGTCCTTCTCACCCACCATCCAGTGTCCCGAGCACCAGACGTATAGGCAGAGGCAGGAGAGCTGAAGCCCCCTGGCCCTGGAAGGATGCCACTAAGAGACCACCCACCTTAGCAGGGCACTTGAGGTCTGGGACTCACCTGAGCAGCTTGGGGACAGTGAACCTGAAGACATCACTGATGATGAGCCTGAGGGTCCCCAGGAGGAAGGTAGAATGGAACACCTGCCAGATGGCCTTCAGCAGTGGGCGCCACTGGCTCCCTTCTTGCCGTAGGAAGGGCTCGGTCTCTGGAGCCTTCATGCCACTGCCGCCTTTCCTTTTAAATGCTATTGCCTTGTTGTGCCTGAGGGGAAGGGAGAGATTAGCTCTGGGTCCCATTTTATACTCTCAGCCGCCAGCGGCAGGGCCAGGCATTAAAGGGTTGTTTTCCCAACAGTGGAGATGGGTGGGTGTGGATCTAGCCTGGCTCCCTCACCTGTTCCTCCTTATCACCCTGAGTACCCACTTAAGAGGCAATCATGGGAGTTGGGGGGCAGGGCAGGAGGGCACTCTGAGGCCTCTTAGATGGCCATGGGAAAGCACACCTGTTGAGCACCTACTATGTGCCAGGCACTCCCCAGTCATCCTAAGACCCCCTGAGAAGCCAGGTGTTGTTCCCATTTCACAGATGAGAAAACTGGGGCTCAGAGAAGCGAACTTGCCCAAGGGCACACAGCTGAGAAGTAAAAGAACTGGAATTTGATTCCAGCTCTCTGCCTCCAGAGCCCATGCACTTTTCTTTTTTCTTTTCCTTTTTTTTTTTTTGAGACGAAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACGGCAACCTCCACTTCCCAGTTCAAGTGATTGTCCCACCTCAGCCTCTCGAGTAGCTGGGATTACAGGCAAGTGCCACCATACCCAGCTAATTTTTGTATTTTCAGTAGAGAAGGGGTTATGCCATGTTGGCCAGGTTGGTTTTGAACTCCTGACCTGAGGTGATCTGCTCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGATGTGAGCCACCACACCTGGCCTCTCATGTACTTTTCAACCTATCGTGTTGTCAACCTGGAGGAAGAACAGCACCCCGTCCCCAACACACACAATCAGCCAGCCCTTAGGTGGTTTTGAACTGGTGGAGAATCACGGCTGATGGGCATGGGGCCTGGTGCTCTAGCTCTGGGTGAAAGTGCAGACAGAAGCTCAGGCTGCCTCAAACTAATAAGATCCCCAGCCTTTGGCTATAACCAGGGGCCACAGAGAAGAGCTAAGGTGAGGGAGGGAGAGGAGGAGATGGGGGAGGCCCGAGGGCCCCTGTGAGGCAGGTCAGAAGCCCTGGGCCAGAAAGGAGAGGCTGGGGCGATGCAGCTGCTGACAGTCCGGTTGCTGTGTGGTCCTGGGCGGGGACACTGCTCCTCTCTCTGTGTGTGAGAGGATGGGTGTGGTCCCCTGCTGAGTCCCCTGTGGCTCTGACAACCTATAAGGTTATCAGTAATTTCTTTTTCTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGTCGCCCAGGCTGGAGTGCAGTGTAGCAATCTCGGCTCACCGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACACACCACCATGCCTGGCTAATTTTTGTATTTTTGGTAGAGACAGGGTTTCACAACGTTAGCCAGGCTGGTCTTAAACTCCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCCCGGCCACTTATCAGTAATTTCAATCCCCATTACAGATCTGTGACCCGGGGCCACGTGCTGGGATCAGCTCTTTACACGAAGGAGCTCACTGACTCCCCTGGATCCCCTTGCCAGGTGAGCATTATTAGGTTTTCCATTTTACAGAAGGGGAAGCTGAGGCTCTGAGAGATGGCGACAGCCGCCCGAGGTCACACAGCAAGGGCAGAGCAGGGATTTGAGCCTAGATCTTGATTTATGGTTTGTAAAGGGTTTCTTGTGCACTAAGGACCCCCAACCTCACCATAATAAAATAATAATAAAAAAAGAAGCATAAGAAAAACCTCTGGTGAGCTCAGGTGGCCAGACCCTTCAAGGCCAAGGTCTCTGTCCCACAT
Task1_train_22433
Here is a genetic alteration in ABCC6 (ATP binding cassette subfamily C member 6) on Chromosome 16. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
AGAAGTGGTGCCTAGACAGTGAGAACAGCTGCAAAGGCCCCAGGGTGGGTGGGGGCCTGGAGTGTTTGAGGAACTGAAAGGAGACCTGTGTGGCTGGAGGAGAGTGAGCATGGGAGGAGGTGACGGGATGAGGTCAGAGACACCCTAGGGACAGATCACACAAGACCTTACAGGAATAACTAAGGAGCTGAGACAGATCACTTGAGGCTAGGAGTTCGAGACCAGCCTGACCAACATGGCAAAACCTTGTCTCTACCAAAAATATAAAAATTAGCTGGGCGTGGTGACACGTGTCTATAGTCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAATAAATACATATAATACAGAGAAATAACTAAGGAAGTGAGAATGTATGGTGAGTGACTCTAATAAGCAAGGACTGAATGCGTTCTCAGCTGCTGATAACATTACTGCCCGCTCAGTGATACTGCTTTTCCTGGCTGGGAAGACCTGCCCTTGTCCCCCAGGGCTCACCTTTCTGTACACCAGGCCAGTGATGGCCGACCGCAACCTCATCTGCAGCACCTTGAGCCTGTACATGTTCTGCTGCTCAAACAGCGTTTGCAGGCAGGCTGAGAGGAACATCAGCACGGCGAGGAGGTAGCCCTTCCAGGCTGGAGGCTTGGGATCACCAATAAACTCCAGGAAAAGGCTTGCAGGGGAAGGAGGGAGAAGGTACAGCTGGTGAGAGGAGGTGCCTAAGGGTGTTGCCTTTGCCCAAACCAGTCCAGATGTGGAGGATCAGTCGGCCCAAACTAGTCCAGGTGTGGAGGATCAGTCAGTGTGGTTTTTTTTGCAATAATGGTCTCCGTTATTTCCCCCACTGTCCATACTCCTTTTCAATCTGACTGCAGCTCCTCAAGATCAAGAGGTGGAGTTTTTGTTCCCACTTGTTATAGGCTAAATTGTGTCCTCACAAAGTTTATATGTTGAAGCCCCGACCCCCAGTACCTCTGAATGTGACTGTATTTGGAAATAGGGCCTTTAAAGAGGCAATGAAGTTAAAAATGAGGTCATTAGGCTGGGCCCTAATCCAATCTGATGGGGTCCTTTTAAGAAGAGGAAATGTAGACACACAAGGAGACACCAGGGGGCGCAAACAGAGGAAAGACCATATGGGGACACAGGGAGGAGGTGGCCAACTGCAAGCCAAGGACAGAGGCCTCAGATGGAACCACCTTGCAGATACTAATCTCGAACTTCCAGCTTTGAGAATCATGATAAAATACATTTCTGTTGTTCAAGCCACTCAGTCTCAGTCTGTGATGCTTTGTTATGTCAGCTGAGCAGACACCACTTGAATCTGGGCTGGCTACAAAACCGGCTTTGGCCAACAGAGTACAGTGGAGGTAAAGCCATGCTGGCTCTGAGCCTAGGCCTCAAGAGAAAATGTGGTTTTTGGTCTATTTCTTAGAACCCTCCCAAGCACCCACATGAACAAGTCTGAGCTAGCCTTTTGGAGGATGGGGACCCACATGGAGCAGAGACAGCCATCCCAGTCTCAGATACACAACTGCAGGCACATGAGAAAACCCAGCCAAGAAAAGAACCACCACCCAGCTGAGCCCAGCCCACATTACTGACCCACATTACCATGAACTAAATAAAAGAATGTTTGTCATTTTAAGCCACTCACTTTTGGGGCATTTTACAGCAAAAACTAATTGATGCAGTCAGGTAAGAGCTTGCTTATTTGCCCTTCTGGGGGTCAGTCACTTTCTCATTAATCCATTTCCCTTCCTCAGTGTCCTTCTCACCCACCATCCAGTGTCCCGAGCACCAGACGTATAGGCAGAGGCAGGAGAGCTGAAGCCCCCTGGCCCTGGAAGGATGCCACTAAGAGACCACCCACCTTAGCAGGGCACTTGAGGTCTGGGACTCACCTGAGCAGCTTGGGGACAGTGAACCTGAAGACATCACTGATGATGAGGCTGAGGGTCCCCAGGAGGAAGGTAGAATGGAACACCTGCCAGATGGCCTTCAGCAGTGGGCGCCACTGGCTCCCTTCTTGCCGTAGGAAGGGCTCGGTCTCTGGAGCCTTCATGCCACTGCCGCCTTTCCTTTTAAATGCTATTGCCTTGTTGTGCCTGAGGGGAAGGGAGAGATTAGCTCTGGGTCCCATTTTATACTCTCAGCCGCCAGCGGCAGGGCCAGGCATTAAAGGGTTGTTTTCCCAACAGTGGAGATGGGTGGGTGTGGATCTAGCCTGGCTCCCTCACCTGTTCCTCCTTATCACCCTGAGTACCCACTTAAGAGGCAATCATGGGAGTTGGGGGGCAGGGCAGGAGGGCACTCTGAGGCCTCTTAGATGGCCATGGGAAAGCACACCTGTTGAGCACCTACTATGTGCCAGGCACTCCCCAGTCATCCTAAGACCCCCTGAGAAGCCAGGTGTTGTTCCCATTTCACAGATGAGAAAACTGGGGCTCAGAGAAGCGAACTTGCCCAAGGGCACACAGCTGAGAAGTAAAAGAACTGGAATTTGATTCCAGCTCTCTGCCTCCAGAGCCCATGCACTTTTCTTTTTTCTTTTCCTTTTTTTTTTTTTGAGACGAAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACGGCAACCTCCACTTCCCAGTTCAAGTGATTGTCCCACCTCAGCCTCTCGAGTAGCTGGGATTACAGGCAAGTGCCACCATACCCAGCTAATTTTTGTATTTTCAGTAGAGAAGGGGTTATGCCATGTTGGCCAGGTTGGTTTTGAACTCCTGACCTGAGGTGATCTGCTCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGATGTGAGCCACCACACCTGGCCTCTCATGTACTTTTCAACCTATCGTGTTGTCAACCTGGAGGAAGAACAGCACCCCGTCCCCAACACACACAATCAGCCAGCCCTTAGGTGGTTTTGAACTGGTGGAGAATCACGGCTGATGGGCATGGGGCCTGGTGCTCTAGCTCTGGGTGAAAGTGCAGACAGAAGCTCAGGCTGCCTCAAACTAATAAGATCCCCAGCCTTTGGCTATAACCAGGGGCCACAGAGAAGAGCTAAGGTGAGGGAGGGAGAGGAGGAGATGGGGGAGGCCCGAGGGCCCCTGTGAGGCAGGTCAGAAGCCCTGGGCCAGAAAGGAGAGGCTGGGGCGATGCAGCTGCTGACAGTCCGGTTGCTGTGTGGTCCTGGGCGGGGACACTGCTCCTCTCTCTGTGTGTGAGAGGATGGGTGTGGTCCCCTGCTGAGTCCCCTGTGGCTCTGACAACCTATAAGGTTATCAGTAATTTCTTTTTCTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGTCGCCCAGGCTGGAGTGCAGTGTAGCAATCTCGGCTCACCGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACACACCACCATGCCTGGCTAATTTTTGTATTTTTGGTAGAGACAGGGTTTCACAACGTTAGCCAGGCTGGTCTTAAACTCCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCCCGGCCACTTATCAGTAATTTCAATCCCCATTACAGATCTGTGACCCGGGGCCACGTGCTGGGATCAGCTCTTTACACGAAGGAGCTCACTGACTCCCCTGGATCCCCTTGCCAGGTGAGCATTATTAGGTTTTCCATTTTACAGAAGGGGAAGCTGAGGCTCTGAGAGATGGCGACAGCCGCCCGAGGTCACACAGCAAGGGCAGAGCAGGGATTTGAGCCTAGATCTTGATTTATGGTTTGTAAAGGGTTTCTTGTGCACTAAGGACCCCCAACCTCACCATAATAAAATAATAATAAAAAAAGAAGCATAAGAAAAACCTCTGGTGAGCTCAGGTGGCCAGACCCTTCAAGGCCAAGGTCTCTGTCCCACAT
AGAAGTGGTGCCTAGACAGTGAGAACAGCTGCAAAGGCCCCAGGGTGGGTGGGGGCCTGGAGTGTTTGAGGAACTGAAAGGAGACCTGTGTGGCTGGAGGAGAGTGAGCATGGGAGGAGGTGACGGGATGAGGTCAGAGACACCCTAGGGACAGATCACACAAGACCTTACAGGAATAACTAAGGAGCTGAGACAGATCACTTGAGGCTAGGAGTTCGAGACCAGCCTGACCAACATGGCAAAACCTTGTCTCTACCAAAAATATAAAAATTAGCTGGGCGTGGTGACACGTGTCTATAGTCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAATAAATACATATAATACAGAGAAATAACTAAGGAAGTGAGAATGTATGGTGAGTGACTCTAATAAGCAAGGACTGAATGCGTTCTCAGCTGCTGATAACATTACTGCCCGCTCAGTGATACTGCTTTTCCTGGCTGGGAAGACCTGCCCTTGTCCCCCAGGGCTCACCTTTCTGTACACCAGGCCAGTGATGGCCGACCGCAACCTCATCTGCAGCACCTTGAGCCTGTACATGTTCTGCTGCTCAAACAGCGTTTGCAGGCAGGCTGAGAGGAACATCAGCACGGCGAGGAGGTAGCCCTTCCAGGCTGGAGGCTTGGGATCACCAATAAACTCCAGGAAAAGGCTTGCAGGGGAAGGAGGGAGAAGGTACAGCTGGTGAGAGGAGGTGCCTAAGGGTGTTGCCTTTGCCCAAACCAGTCCAGATGTGGAGGATCAGTCGGCCCAAACTAGTCCAGGTGTGGAGGATCAGTCAGTGTGGTTTTTTTTGCAATAATGGTCTCCGTTATTTCCCCCACTGTCCATACTCCTTTTCAATCTGACTGCAGCTCCTCAAGATCAAGAGGTGGAGTTTTTGTTCCCACTTGTTATAGGCTAAATTGTGTCCTCACAAAGTTTATATGTTGAAGCCCCGACCCCCAGTACCTCTGAATGTGACTGTATTTGGAAATAGGGCCTTTAAAGAGGCAATGAAGTTAAAAATGAGGTCATTAGGCTGGGCCCTAATCCAATCTGATGGGGTCCTTTTAAGAAGAGGAAATGTAGACACACAAGGAGACACCAGGGGGCGCAAACAGAGGAAAGACCATATGGGGACACAGGGAGGAGGTGGCCAACTGCAAGCCAAGGACAGAGGCCTCAGATGGAACCACCTTGCAGATACTAATCTCGAACTTCCAGCTTTGAGAATCATGATAAAATACATTTCTGTTGTTCAAGCCACTCAGTCTCAGTCTGTGATGCTTTGTTATGTCAGCTGAGCAGACACCACTTGAATCTGGGCTGGCTACAAAACCGGCTTTGGCCAACAGAGTACAGTGGAGGTAAAGCCATGCTGGCTCTGAGCCTAGGCCTCAAGAGAAAATGTGGTTTTTGGTCTATTTCTTAGAACCCTCCCAAGCACCCACATGAACAAGTCTGAGCTAGCCTTTTGGAGGATGGGGACCCACATGGAGCAGAGACAGCCATCCCAGTCTCAGATACACAACTGCAGGCACATGAGAAAACCCAGCCAAGAAAAGAACCACCACCCAGCTGAGCCCAGCCCACATTACTGACCCACATTACCATGAACTAAATAAAAGAATGTTTGTCATTTTAAGCCACTCACTTTTGGGGCATTTTACAGCAAAAACTAATTGATGCAGTCAGGTAAGAGCTTGCTTATTTGCCCTTCTGGGGGTCAGTCACTTTCTCATTAATCCATTTCCCTTCCTCAGTGTCCTTCTCACCCACCATCCAGTGTCCCGAGCACCAGACGTATAGGCAGAGGCAGGAGAGCTGAAGCCCCCTGGCCCTGGAAGGATGCCACTAAGAGACCACCCACCTTAGCAGGGCACTTGAGGTCTGGGACTCACCTGAGCAGCTTGGGGACAGTGAACCTGAAGACATCACTGATGATGAGTCTGAGGGTCCCCAGGAGGAAGGTAGAATGGAACACCTGCCAGATGGCCTTCAGCAGTGGGCGCCACTGGCTCCCTTCTTGCCGTAGGAAGGGCTCGGTCTCTGGAGCCTTCATGCCACTGCCGCCTTTCCTTTTAAATGCTATTGCCTTGTTGTGCCTGAGGGGAAGGGAGAGATTAGCTCTGGGTCCCATTTTATACTCTCAGCCGCCAGCGGCAGGGCCAGGCATTAAAGGGTTGTTTTCCCAACAGTGGAGATGGGTGGGTGTGGATCTAGCCTGGCTCCCTCACCTGTTCCTCCTTATCACCCTGAGTACCCACTTAAGAGGCAATCATGGGAGTTGGGGGGCAGGGCAGGAGGGCACTCTGAGGCCTCTTAGATGGCCATGGGAAAGCACACCTGTTGAGCACCTACTATGTGCCAGGCACTCCCCAGTCATCCTAAGACCCCCTGAGAAGCCAGGTGTTGTTCCCATTTCACAGATGAGAAAACTGGGGCTCAGAGAAGCGAACTTGCCCAAGGGCACACAGCTGAGAAGTAAAAGAACTGGAATTTGATTCCAGCTCTCTGCCTCCAGAGCCCATGCACTTTTCTTTTTTCTTTTCCTTTTTTTTTTTTTGAGACGAAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACGGCAACCTCCACTTCCCAGTTCAAGTGATTGTCCCACCTCAGCCTCTCGAGTAGCTGGGATTACAGGCAAGTGCCACCATACCCAGCTAATTTTTGTATTTTCAGTAGAGAAGGGGTTATGCCATGTTGGCCAGGTTGGTTTTGAACTCCTGACCTGAGGTGATCTGCTCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGATGTGAGCCACCACACCTGGCCTCTCATGTACTTTTCAACCTATCGTGTTGTCAACCTGGAGGAAGAACAGCACCCCGTCCCCAACACACACAATCAGCCAGCCCTTAGGTGGTTTTGAACTGGTGGAGAATCACGGCTGATGGGCATGGGGCCTGGTGCTCTAGCTCTGGGTGAAAGTGCAGACAGAAGCTCAGGCTGCCTCAAACTAATAAGATCCCCAGCCTTTGGCTATAACCAGGGGCCACAGAGAAGAGCTAAGGTGAGGGAGGGAGAGGAGGAGATGGGGGAGGCCCGAGGGCCCCTGTGAGGCAGGTCAGAAGCCCTGGGCCAGAAAGGAGAGGCTGGGGCGATGCAGCTGCTGACAGTCCGGTTGCTGTGTGGTCCTGGGCGGGGACACTGCTCCTCTCTCTGTGTGTGAGAGGATGGGTGTGGTCCCCTGCTGAGTCCCCTGTGGCTCTGACAACCTATAAGGTTATCAGTAATTTCTTTTTCTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGTCGCCCAGGCTGGAGTGCAGTGTAGCAATCTCGGCTCACCGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACACACCACCATGCCTGGCTAATTTTTGTATTTTTGGTAGAGACAGGGTTTCACAACGTTAGCCAGGCTGGTCTTAAACTCCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCCCGGCCACTTATCAGTAATTTCAATCCCCATTACAGATCTGTGACCCGGGGCCACGTGCTGGGATCAGCTCTTTACACGAAGGAGCTCACTGACTCCCCTGGATCCCCTTGCCAGGTGAGCATTATTAGGTTTTCCATTTTACAGAAGGGGAAGCTGAGGCTCTGAGAGATGGCGACAGCCGCCCGAGGTCACACAGCAAGGGCAGAGCAGGGATTTGAGCCTAGATCTTGATTTATGGTTTGTAAAGGGTTTCTTGTGCACTAAGGACCCCCAACCTCACCATAATAAAATAATAATAAAAAAAGAAGCATAAGAAAAACCTCTGGTGAGCTCAGGTGGCCAGACCCTTCAAGGCCAAGGTCTCTGTCCCACAT
Task1_train_22434
This variant affects the gene ABCC6 (ATP binding cassette subfamily C member 6) found on Chromosome 16. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Autosomal recessive inherited pseudoxanthoma elasticum
TTATTTTTTTGAGATGGAATCTCACTCTGTTGCTCAGGCTGGAGTGCACTGGTGTGATCTCGGCTCACCGCAACCTCCACCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTGACTGGGATTGCAGGCTCCCACCACCACACCTGGCTAATTTTTATATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAAATCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAGGTGTTGGGATTATAGGCGTGAGCCACTGCGCCAGGCCACCAAGTTCCCTTTTCTAATGCAGAGCCAACTTGGGGAAGCAACCGTTCTGACATAGAAATTATTAACGTGGCTTGATTTTCCCTGAAATTATTTTTGGAGTTCTCCTATATGGCAAGTGATGCTATAGATTTTTCCTATTTTAGCAGTGATAGAGAGTTTCTTTTTAAAAACAGTTTATTCGAGTAAAAAAAGTGACTCAATTTAGTTTTTGCCCCAGTAGGACAAAAAAGCATCAAGAGTGGTCCATAAATGCTTAAGTTTGGGAAGCAGGGGCTGGACCCCCCAGTAGAGCTGTTTCGAAAACCTCTAAGCTCTTTCTACCAGTTCCACACATTCAAAGCCTGATATTTTTCATTTATTTAATAGCCATTTAGGCCGGGTGCGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGTCGAGTGGGGTAGATCACTTGAGGTCAGGAGTTTGAGACCAGCTTGGCCAACGTGGTGAAACCCGGTCTCTACAAAAAACTACAAAAATTAGCTGGGCATGATGGCAGGCGCCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCATTGCACTGCAGCCTGGGCAACAAGAGTGAAACTCTGTCTCAAAAAAAAAAAGAGAAAATGAATAGCCCAGGCACAGTGGGTCACACCTGTAATCCCAGCACTTTGGGAAGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTTCAGATCAGCCTGACCAACATGGAGAAACACTGTCTCTACTAAAAATACAAAATTAGCCGAGCATAGTGGTGCATGCCTGTAATCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATAGTGCCATTGTACTCCAGCCTGGGCAACAAGAACGGAACTCCATCTCAAAAGAAAAAAAAATAATTACCACTTAAACTCATTATTTGCCAGGCCCTGTTCTAAGTGCTTTACAGATCTCATCTTATTTAAGCTTCACAACCCTATGAGCTAAGTGCTACTATCAATCCCATTTTGAAGGAGTGGAGACTGAGGCACAGAGAGGTTAAGTAACTGTCCAAAGCAACACAGCTAGGAAGTGGTAGGGCCAGGATTCAAATCCATATGTCAGGTGCTACTGAGGTCTGAATGCCGTGTGGTTAGGAGAGAGCACATCCTCAAGTGCCTTGTGAGCTGGCCCTGGAGAAGCAGCTGTTTTCTCAATCTGCCTGGAACCCTCTAGAAAGTAGACACTTGCTCCTTTATCTCCTCACCCCTGGGGCTTAGCACATAGTAGGTGCCTATTAAATGTTGGTGGAATGACTGAAATCAAGTATTGGAGACAATTCTAATTACTATTAAGCACCCGCTGTGTGCAAGCACTAAGCACTTTCCGTCTCATGCAGGTTGAGTCATCCCCATTTTACAGAGGGAAAACTGAGACTCCGGAGGTTTGCGACATGGCCTGCTAACAGGCAGAGCCGGGATTCAAATCAAGATCTCACTCCAGTGAGTGAATGGGAACAGGATGCAGATGGTAGACACTGAACACGAAGAAGAAAGCACTGAGGCTGGGATGAAGAAAGACTTGCTGGCCTTTGTAAGCACAGGGGAAGGGCCATGGCTGGGAATCAGAGCAGCAAATGCAGGCGGGTGAGGCACCACCCCAACCCTTCCGTGCGACTTTACTTACCCAGAAACCCACCAGAACGTGGCTTTGGAGGGGAAGGCTGCCCCAGTCTCTGGACAGGGGTTCTGCAACAGACAAAAATGGAGAAGGGAAGTATGTGGCAAGGGTAGGAAGACAGGACGAACTGTGTATTTTTTTTTTTTTCGAGACAGGGTTTCGCTCTGTTGCCCAGGCCAGAGTACAGCGGTGTGATCTTGGCTCACTACTACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTTCCAAAGAGCTGGGATGACAGGTGTGCGCCACCACACACAGCTAATTTTTTGTGTTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTAACCTCAAGTGATCTGCCTATCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTACACCCAGCCCTGACGGTGTATTTAGTACTGAAAGTAAACATCGAGGTGCCCTGTCTCCTTGCCAGGGGTGTAGACCAGTGAGCTTGGTGCTTCCCAGCAGGCAGCGTAAAAAGAGGTTGGGCCACAGGCCTGACAATGTCCACAAGGTAAGAAATAACAGTGGCTCAGAAGAACAACTATGATTATACTGAAACCAAAACCTTGCTTTGCTTCTCAAAAGGAAGGACACTGCATAACGAAGAAATTAGATCCTTGACAATATCCCTCGGCAAATGTTGTGAAGACAGACCTGTCGTGCGATTTTTGTCAGGTGCTCCAGGAAGATTACAACAGTCTGTACTCTTTACCAATAAGGCGTGAAGGTGCCCATTTCACCACGTTTTTGCCATCACAGCTTATTAATTTTTAAATTTTGTTGCTACTCTGGTAGGTACAAAAAAGATTCCTATGATAGTTTTAACTATTCTCAAGCCTTCGAGCAATTTTTTTTTTTTTTTTTTTGAATACAGGGTCTCGCTCTGTCACCCAGGCTGGAGTGCAATGGTGCAATCATAGCTCACTGCAGCCTTTATCTCTTGGATTCAAGCAATCCTCCTGCTTTAGTCTCCACAGAGCTACTCTGTAGTGGGACTACAGGCATGCACCACCACACTAGGCTATTTTTAAAAACCTTTTTGTAGAGATGGGGTCTCACTACATTGCCTAGTCTGATCTAGAACACCTGGGCACAAACAATCCTCCTTCCTCGGTCTCCCAAAGTGTTGAGATTACAGGCATGATCCACTGCATCTGGCCCCATTTGAACATCTGTTTATATGATGTCAGATCAGTCTCTTCCACAAAAGAATTGTTTCTTGATTTCACAGACTGCTTCACTGTTACCTATTGTAAATCTCTCAATCTCTCATGAGCTTCTTCTATGGAGCACTTACCCCAAGGGTAATTTTCTTTTTCCTTCTTTTTTTTTTTTTTTTTTTTTGGTGGAGTTCCGCTCTTGTTGCCCAGGCTGGAGTGCAAATGCACAGTCTTGGCTCCCTGCAACCTCCACATCCCGGATTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGCACCACCATGCCTGGCTAATTTTTGTAATTTTAGAAGAGATGAGGCTTTACCATGTTGGCCAGGCTGGCTTTGAACTCTCGACCTCAAGTGATCCACCTGCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACTGTGACCATCCAATTTTCAACATATTTGTTTAATTTTGTGACCAGTGTCTGGTTCCCCTGCTTGACCAGTAGCTACGTGAGAACAGAAACTCTATCTGCTTGTTCACCATAGATCCTTATGCCCTTGCTAGGGCATAGCGGGGTTTGGCAAACTATGACCAAATCTGGCCCACTGCCTGTTTCTGCAAATAGTGTTATTGCAACACAGCCATGCAATTTGTTGACATATTCTGCTTTTGCGTTCAATGGCAGAGTTGAGTAATTGCCACTGAGATCACTGTATGGCTCACAGAGTCCAAAATATTTTCTCTTGGCCCATATAGAAAAAGTCTGCCAACTGTGGCATCGAGTAGAAATGTGGTACACTTTTTGCTGAATGGCTAAATGAATA
TTATTTTTTTGAGATGGAATCTCACTCTGTTGCTCAGGCTGGAGTGCACTGGTGTGATCTCGGCTCACCGCAACCTCCACCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTGACTGGGATTGCAGGCTCCCACCACCACACCTGGCTAATTTTTATATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAAATCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAGGTGTTGGGATTATAGGCGTGAGCCACTGCGCCAGGCCACCAAGTTCCCTTTTCTAATGCAGAGCCAACTTGGGGAAGCAACCGTTCTGACATAGAAATTATTAACGTGGCTTGATTTTCCCTGAAATTATTTTTGGAGTTCTCCTATATGGCAAGTGATGCTATAGATTTTTCCTATTTTAGCAGTGATAGAGAGTTTCTTTTTAAAAACAGTTTATTCGAGTAAAAAAAGTGACTCAATTTAGTTTTTGCCCCAGTAGGACAAAAAAGCATCAAGAGTGGTCCATAAATGCTTAAGTTTGGGAAGCAGGGGCTGGACCCCCCAGTAGAGCTGTTTCGAAAACCTCTAAGCTCTTTCTACCAGTTCCACACATTCAAAGCCTGATATTTTTCATTTATTTAATAGCCATTTAGGCCGGGTGCGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGTCGAGTGGGGTAGATCACTTGAGGTCAGGAGTTTGAGACCAGCTTGGCCAACGTGGTGAAACCCGGTCTCTACAAAAAACTACAAAAATTAGCTGGGCATGATGGCAGGCGCCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCATTGCACTGCAGCCTGGGCAACAAGAGTGAAACTCTGTCTCAAAAAAAAAAAGAGAAAATGAATAGCCCAGGCACAGTGGGTCACACCTGTAATCCCAGCACTTTGGGAAGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTTCAGATCAGCCTGACCAACATGGAGAAACACTGTCTCTACTAAAAATACAAAATTAGCCGAGCATAGTGGTGCATGCCTGTAATCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATAGTGCCATTGTACTCCAGCCTGGGCAACAAGAACGGAACTCCATCTCAAAAGAAAAAAAAATAATTACCACTTAAACTCATTATTTGCCAGGCCCTGTTCTAAGTGCTTTACAGATCTCATCTTATTTAAGCTTCACAACCCTATGAGCTAAGTGCTACTATCAATCCCATTTTGAAGGAGTGGAGACTGAGGCACAGAGAGGTTAAGTAACTGTCCAAAGCAACACAGCTAGGAAGTGGTAGGGCCAGGATTCAAATCCATATGTCAGGTGCTACTGAGGTCTGAATGCCGTGTGGTTAGGAGAGAGCACATCCTCAAGTGCCTTGTGAGCTGGCCCTGGAGAAGCAGCTGTTTTCTCAATCTGCCTGGAACCCTCTAGAAAGTAGACACTTGCTCCTTTATCTCCTCACCCCTGGGGCTTAGCACATAGTAGGTGCCTATTAAATGTTGGTGGAATGACTGAAATCAAGTATTGGAGACAATTCTAATTACTATTAAGCACCCGCTGTGTGCAAGCACTAAGCACTTTCCGTCTCATGCAGGTTGAGTCATCCCCATTTTACAGAGGGAAAACTGAGACTCCGGAGGTTTGCGACATGGCCTGCTAACAGGCAGAGCCGGGATTCAAATCAAGATCTCACTCCAGTGAGTGAATGGGAACAGGATGCAGATGGTAGACACTGAACACGAAGAAGAAAGCACTGAGGCTGGGATGAAGAAAGACTTGCTGGCCTTTGTAAGCACAGGGGAAGGGCCATGGCTGGGAATCAGAGCAGCAAATGCAGGCGGGTGAGGCACCACCCCAACCCTTCCGTGCGACTTTACTTACCCAGAAACACACCAGAACGTGGCTTTGGAGGGGAAGGCTGCCCCAGTCTCTGGACAGGGGTTCTGCAACAGACAAAAATGGAGAAGGGAAGTATGTGGCAAGGGTAGGAAGACAGGACGAACTGTGTATTTTTTTTTTTTTCGAGACAGGGTTTCGCTCTGTTGCCCAGGCCAGAGTACAGCGGTGTGATCTTGGCTCACTACTACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTTCCAAAGAGCTGGGATGACAGGTGTGCGCCACCACACACAGCTAATTTTTTGTGTTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTAACCTCAAGTGATCTGCCTATCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTACACCCAGCCCTGACGGTGTATTTAGTACTGAAAGTAAACATCGAGGTGCCCTGTCTCCTTGCCAGGGGTGTAGACCAGTGAGCTTGGTGCTTCCCAGCAGGCAGCGTAAAAAGAGGTTGGGCCACAGGCCTGACAATGTCCACAAGGTAAGAAATAACAGTGGCTCAGAAGAACAACTATGATTATACTGAAACCAAAACCTTGCTTTGCTTCTCAAAAGGAAGGACACTGCATAACGAAGAAATTAGATCCTTGACAATATCCCTCGGCAAATGTTGTGAAGACAGACCTGTCGTGCGATTTTTGTCAGGTGCTCCAGGAAGATTACAACAGTCTGTACTCTTTACCAATAAGGCGTGAAGGTGCCCATTTCACCACGTTTTTGCCATCACAGCTTATTAATTTTTAAATTTTGTTGCTACTCTGGTAGGTACAAAAAAGATTCCTATGATAGTTTTAACTATTCTCAAGCCTTCGAGCAATTTTTTTTTTTTTTTTTTTGAATACAGGGTCTCGCTCTGTCACCCAGGCTGGAGTGCAATGGTGCAATCATAGCTCACTGCAGCCTTTATCTCTTGGATTCAAGCAATCCTCCTGCTTTAGTCTCCACAGAGCTACTCTGTAGTGGGACTACAGGCATGCACCACCACACTAGGCTATTTTTAAAAACCTTTTTGTAGAGATGGGGTCTCACTACATTGCCTAGTCTGATCTAGAACACCTGGGCACAAACAATCCTCCTTCCTCGGTCTCCCAAAGTGTTGAGATTACAGGCATGATCCACTGCATCTGGCCCCATTTGAACATCTGTTTATATGATGTCAGATCAGTCTCTTCCACAAAAGAATTGTTTCTTGATTTCACAGACTGCTTCACTGTTACCTATTGTAAATCTCTCAATCTCTCATGAGCTTCTTCTATGGAGCACTTACCCCAAGGGTAATTTTCTTTTTCCTTCTTTTTTTTTTTTTTTTTTTTTGGTGGAGTTCCGCTCTTGTTGCCCAGGCTGGAGTGCAAATGCACAGTCTTGGCTCCCTGCAACCTCCACATCCCGGATTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGCACCACCATGCCTGGCTAATTTTTGTAATTTTAGAAGAGATGAGGCTTTACCATGTTGGCCAGGCTGGCTTTGAACTCTCGACCTCAAGTGATCCACCTGCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACTGTGACCATCCAATTTTCAACATATTTGTTTAATTTTGTGACCAGTGTCTGGTTCCCCTGCTTGACCAGTAGCTACGTGAGAACAGAAACTCTATCTGCTTGTTCACCATAGATCCTTATGCCCTTGCTAGGGCATAGCGGGGTTTGGCAAACTATGACCAAATCTGGCCCACTGCCTGTTTCTGCAAATAGTGTTATTGCAACACAGCCATGCAATTTGTTGACATATTCTGCTTTTGCGTTCAATGGCAGAGTTGAGTAATTGCCACTGAGATCACTGTATGGCTCACAGAGTCCAAAATATTTTCTCTTGGCCCATATAGAAAAAGTCTGCCAACTGTGGCATCGAGTAGAAATGTGGTACACTTTTTGCTGAATGGCTAAATGAATA
Task1_train_22435
An alteration has been detected in LOC102723692, XYLT1 (uncharacterized LOC102723692| xylosyltransferase 1) on Chromosome 16. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Desbuquois dysplasia 2
GAGCACAGCTTAGCACTGTAGAGAGTTAGACCACCTGAATTCAAATCCTCATTTGGCTACCGTCTAGCTGTGCAGGTCAAGTTACTCAAACTCTCTGGGCCTCAGCATCCTTAAAATGGGTTACTAGCATAGTGTCTAGCACATAGTGTAGGCTGCTCTTTGATTATTATCACCAGCCCCTTGTTACCAGGAACCCATCTAGGGGCAGAACAAACTCCTTTCTCTGCCTGCGATTCCGACCATAGCTGGATCTTCTAACAAACAGGGCACGTTACCATATTATTCTTTCTCTCCAAGTTCTTCGCGCAAGAACTCTGAGTTCCTTACAGGCAGCAGTGTCTTGACTCTAGATCTTGGGGGATATTCTTAATCTCTGCTTGCTGTGAACACATGAGGCACTCCTTGTCAGAGGCTACAATGTCCCCAGGATGCCGGGCTAGGATACAAATGCTTGTGCCTGGGGGAGTGCAGGGCTCTGGGAATCAGCACGTGGAGGTTTTGTGCTCTAAGTGATGAAGATTCTCTGCGATTAGGGCAGTGAGGGACGGGTCCTCTCCAAACATGGGAATTCATTGAATAGGTCAAACAAACATTCCCCTGCAACCCTCTTTCGGCTCAGCATATCCTTTCTGCAGGGAAGATGTGAGTTTAGGCAGCCCCCTGTCTGCCAGCTTAAGGTGGCTGGAGCTGCTGTGTGGGAACCTTAAGGGGAATACGAACGACAGAAAACCTGCAGTGTACTCTGCATTCATACAGGCACAAAAACCAGGAAGGCAGCAGGGACTGCTGGAAAAAAACCCCACTTGGAACACCCCTCCATGCCTTCGTTTCCTTACCTGAACAATAAAAGTGATGTCTGCCCCAGTAAAGCCAATGCCCACACAGCCCGGCACAGAGGAGATCAAACACAAACAAACAGCATCCCGCTCCACATCAAGGGCACCTTGGCTGGGTTATGAGCCTGGCATTGTGTCCCTGCCTTCCTGTGTTAGTGGTTTGGGAAGTAGCATACCGTCTCTACACGGTGGCTCTAGTGACCTCAGAGTGATTCGCTTAACCATTCAGTGGCACTCATATTTGTGCTCTCTGCTGCTAGGTGTGGGGAGGGCTGGAGGAAGAAGCCACCATGCTGGCTTGGAGGGAGCAGAGCAGGAAGGGGTGCCCATCTTGGGGCCAAGCACTCTCAGGGCTCATGGTAAGTGGATGAGCATTCCCCACCCTCCTGCTCTGCCCTTCCCCAGAACTGTAAATTGTTAGGCTGCCCAGAGACAGCTGTAAAGGGGATAATGTTCTACCTCTTCTTACTCCTTCAAGTACACAGAACACAGTGTTTTCCCACAGAACACAGTGGTTTCCAAACCTGGCTGCTCCTCAGAAAAGTGCAATTCATTAAAAATACAAATTCGTCGATATCACTGATGAGGGTTTCTCAACCAGAGGTGCTGCTAAGCATCCTACCCATGCATGGGACAGCATGTCCCAACAGAGAATCATCCAGCCACAATGGCAAGAGTTCTGAGGTTGAAAAGCTCAGCCCTAGATATATACTTAAAAGCATATTCCTGGGTACAAATGTAACAAATATTTTGGGAGATTCTGATGAAAAGGGAATAAAGAGAAGATGATATGAGTATGGCCTTTGGAAAGTTTTTTTTAACCTTTCTGTGCCTCACAGTTTTCATATCCCTAAAATGGAATAATAATGAAAGGTCATTTGTTGTTTTTGGGTTAATGAGTCAATGTGGTTAGAACATCCCTGAAGTAAGTGCTCAATAAACACTGGCTATTGTTGATACTGTTAACTATTATTAATTATCAACAGCCAGGTTTGGGCACCATGTGATAAGATGACCTGCAGGTCTGGCCTTGGATTTCTGCAGAGGTTTGTTGGGAAGGCATCACTTAGGAGGCTGGCAGACCATGAGAAAGTCTCACCTGGAAGCGGTGGAAGTCCTGCGGCTTGAAGTCATTGGGGGAGCAGCCGCACCAGTCCACGATGTGCTTGTACTGGCACTTGCAGCCCAGCTTGCGATTCCAGTTGGTGATGCGCAGGTTGTTGTCCACCATGGTGTCGCAGTGGGGGCTGTTCTCCAGGACCGTATGGAAGAAGGACTGCAGGGGAGAGAGGGACCCAGCCTGAGACCTCTCCCAGCCTCCCACAGATGAACTGGGGTGGGAAATGGTGAACCCTTGCTCTGAGTTCATGTAAGAACTGGTTGTTTAAAAGAATGTGGCATCTCATCAGAAGCTGGGCGGCTTCCTGTACAGCTTGCAGAACTGCAAGCCAAATAAACCTCTTTTCTTTATAAATTACCAAGCCTCAGATTTTCCTTCATAGCAATGCAAAAATGTATAACACAACTACCTGACTGTCAAGGGACTCTTATGTTCTCTGCATGCATTTGAGGTCAGCTGCCCATGTGGTCCAACTCAGAGCGCAGGCGGATGCTCTGTCCAACAGACAAATCAAAGGGATTCAAGTCTGACTGACTGACTGGTGTGCTGGAATTTCACCCCTGGGGTAGGGAGACCAGATTGATGGTTGCATTAGACCCAGGGCTTCCTGCATCGCCAGACGGCAACATAGGGAAGGGAGTGGGTGGGGCTGCTTGCTGTCCATGGTACTGAACCAGGTGCCATATTTTCTCCCTAATCCCAGGATTCTTGGCCAACTGCTTTAAGGGATCTGAGAAAGAGGCCATGTTGGATCTGAAAAGAAAAACTAGAGGAGAAACAATCAATCACTGGAGTACTTGAGAGACTGCCAGAGAGTGAGAGAAAGATTTCTATAATAGACAGTCCCAGGCAAATATATTTCCTCCCTGTTCTCTCTCCCTAAGGGAAGCTGTTGGGGAATCTGTGTCTGCCCGTTACAAGTTAATGGGCACAGCCTTCTGATTTCTTCTAAACCAGTCCTCTTGAAGTGGTCTGGGAGAAGGGAGGGAAGGCAGAGATGCAGGAGGTGGGACTGAACAGAGACCCTGGAGTATATGTGCTTGTGTGTGCTGGGGCCAGGGAGGGGCAGAGAAAGCACACACACGGAGCTTTGGTCACCAGTATCGTGGTGGGCGTCTTGATTAAAAATAGCCAAACTCCCAAACAATCTCTTCTAAATGGATGGGTGGGTAAATGAGGCTCCAGCCGCCACCCCCTGCTGACCTTCCTGTGACACTAAATGACAAGCCCATGAACCTGGATTTTAAGCTTGAATTGCCTACAAGCCCAGGGAGGCATACATTCTCCAACAAGCAGTGGGAAGATGTACCCAATTACTGATTGCCCTGTGTCCTTTCATAATGATACAGAAATTCCCTGCAATATAATGGATGAGGAGGTTATCAGAATTGAGAGAAGAGGTGATTGATTTTTGCTGAAATAGGATTAAAAGCTGATTACTTAACATGTGTGCAGAATAGTAAAACCTGGCCCAGTGATGACAAGCTCATCATCCCTCTGGGTGATGGGGGCAGTCAGCCCTCCCCGGAGCTTGGCACTGCCCCAGACACAGGTGAGAGATGTGCTGGGAGTGTGGCCTGCAGAAACACACATAACCTATGTGGTCCCGGGAAGGAACAAGGGACCGTTCATGAGAAATGCCATAGACTCAATAGAAACGGAACCAGCTCTGCACTGTTCTCAAGCTGGATTGGAAATGAGGGTGCAATCAACCTGGAGGTCAGGAAGATGAATCTGGAATCCCTCAACCCAGCTCTGACCGGCAGGCAGCTAAGGGAATGTCAGTGACAATCCTTCAGAACTGGATCCCCTCCCCACTTCTAGATGGGGCTAGGACTGTTTTAGAATACTCTGGATTAATGGAGTATGACTTATGAAACCAACACCCTTTTCTTCAGGGAATAATAGAGCAATGTTCAACATGAGAAAAGGCATGCTTGGTGTAAAAAGGTGGTCATTACATGATTGGTCATTGTGAAGGATGCGTCAAAAGTTGATGTGGCGGCCGGGCATGGTGGCTCATGCCTGCAATCCCAGCACTTTGAGAGGCTGAGGCAGGAGGACCACTTGAGGCCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAG
GAGCACAGCTTAGCACTGTAGAGAGTTAGACCACCTGAATTCAAATCCTCATTTGGCTACCGTCTAGCTGTGCAGGTCAAGTTACTCAAACTCTCTGGGCCTCAGCATCCTTAAAATGGGTTACTAGCATAGTGTCTAGCACATAGTGTAGGCTGCTCTTTGATTATTATCACCAGCCCCTTGTTACCAGGAACCCATCTAGGGGCAGAACAAACTCCTTTCTCTGCCTGCGATTCCGACCATAGCTGGATCTTCTAACAAACAGGGCACGTTACCATATTATTCTTTCTCTCCAAGTTCTTCGCGCAAGAACTCTGAGTTCCTTACAGGCAGCAGTGTCTTGACTCTAGATCTTGGGGGATATTCTTAATCTCTGCTTGCTGTGAACACATGAGGCACTCCTTGTCAGAGGCTACAATGTCCCCAGGATGCCGGGCTAGGATACAAATGCTTGTGCCTGGGGGAGTGCAGGGCTCTGGGAATCAGCACGTGGAGGTTTTGTGCTCTAAGTGATGAAGATTCTCTGCGATTAGGGCAGTGAGGGACGGGTCCTCTCCAAACATGGGAATTCATTGAATAGGTCAAACAAACATTCCCCTGCAACCCTCTTTCGGCTCAGCATATCCTTTCTGCAGGGAAGATGTGAGTTTAGGCAGCCCCCTGTCTGCCAGCTTAAGGTGGCTGGAGCTGCTGTGTGGGAACCTTAAGGGGAATACGAACGACAGAAAACCTGCAGTGTACTCTGCATTCATACAGGCACAAAAACCAGGAAGGCAGCAGGGACTGCTGGAAAAAAACCCCACTTGGAACACCCCTCCATGCCTTCGTTTCCTTACCTGAACAATAAAAGTGATGTCTGCCCCAGTAAAGCCAATGCCCACACAGCCCGGCACAGAGGAGATCAAACACAAACAAACAGCATCCCGCTCCACATCAAGGGCACCTTGGCTGGGTTATGAGCCTGGCATTGTGTCCCTGCCTTCCTGTGTTAGTGGTTTGGGAAGTAGCATACCGTCTCTACACGGTGGCTCTAGTGACCTCAGAGTGATTCGCTTAACCATTCAGTGGCACTCATATTTGTGCTCTCTGCTGCTAGGTGTGGGGAGGGCTGGAGGAAGAAGCCACCATGCTGGCTTGGAGGGAGCAGAGCAGGAAGGGGTGCCCATCTTGGGGCCAAGCACTCTCAGGGCTCATGGTAAGTGGATGAGCATTCCCCACCCTCCTGCTCTGCCCTTCCCCAGAACTGTAAATTGTTAGGCTGCCCAGAGACAGCTGTAAAGGGGATAATGTTCTACCTCTTCTTACTCCTTCAAGTACACAGAACACAGTGTTTTCCCACAGAACACAGTGGTTTCCAAACCTGGCTGCTCCTCAGAAAAGTGCAATTCATTAAAAATACAAATTCGTCGATATCACTGATGAGGGTTTCTCAACCAGAGGTGCTGCTAAGCATCCTACCCATGCATGGGACAGCATGTCCCAACAGAGAATCATCCAGCCACAATGGCAAGAGTTCTGAGGTTGAAAAGCTCAGCCCTAGATATATACTTAAAAGCATATTCCTGGGTACAAATGTAACAAATATTTTGGGAGATTCTGATGAAAAGGGAATAAAGAGAAGATGATATGAGTATGGCCTTTGGAAAGTTTTTTTTAACCTTTCTGTGCCTCACAGTTTTCATATCCCTAAAATGGAATAATAATGAAAGGTCATTTGTTGTTTTTGGGTTAATGAGTCAATGTGGTTAGAACATCCCTGAAGTAAGTGCTCAATAAACACTGGCTATTGTTGATACTGTTAACTATTATTAATTATCAACAGCCAGGTTTGGGCACCATGTGATAAGATGACCTGCAGGTCTGGCCTTGGATTTCTGCAGAGGTTTGTTGGGAAGGCATCACTTAGGAGGCTGGCAGACCATGAGAAAGTCTCACCTGGAAGCGGTGGAAGTCCTGCGGCTTGAAGTCATTGGGGGAGCAGCCGCACCAGTCCACGATGTGCTTGTACTGGCACTTGCAGCCCAGCTTGCGATTCCAGTTGGTGATGCACAGGTTGTTGTCCACCATGGTGTCGCAGTGGGGGCTGTTCTCCAGGACCGTATGGAAGAAGGACTGCAGGGGAGAGAGGGACCCAGCCTGAGACCTCTCCCAGCCTCCCACAGATGAACTGGGGTGGGAAATGGTGAACCCTTGCTCTGAGTTCATGTAAGAACTGGTTGTTTAAAAGAATGTGGCATCTCATCAGAAGCTGGGCGGCTTCCTGTACAGCTTGCAGAACTGCAAGCCAAATAAACCTCTTTTCTTTATAAATTACCAAGCCTCAGATTTTCCTTCATAGCAATGCAAAAATGTATAACACAACTACCTGACTGTCAAGGGACTCTTATGTTCTCTGCATGCATTTGAGGTCAGCTGCCCATGTGGTCCAACTCAGAGCGCAGGCGGATGCTCTGTCCAACAGACAAATCAAAGGGATTCAAGTCTGACTGACTGACTGGTGTGCTGGAATTTCACCCCTGGGGTAGGGAGACCAGATTGATGGTTGCATTAGACCCAGGGCTTCCTGCATCGCCAGACGGCAACATAGGGAAGGGAGTGGGTGGGGCTGCTTGCTGTCCATGGTACTGAACCAGGTGCCATATTTTCTCCCTAATCCCAGGATTCTTGGCCAACTGCTTTAAGGGATCTGAGAAAGAGGCCATGTTGGATCTGAAAAGAAAAACTAGAGGAGAAACAATCAATCACTGGAGTACTTGAGAGACTGCCAGAGAGTGAGAGAAAGATTTCTATAATAGACAGTCCCAGGCAAATATATTTCCTCCCTGTTCTCTCTCCCTAAGGGAAGCTGTTGGGGAATCTGTGTCTGCCCGTTACAAGTTAATGGGCACAGCCTTCTGATTTCTTCTAAACCAGTCCTCTTGAAGTGGTCTGGGAGAAGGGAGGGAAGGCAGAGATGCAGGAGGTGGGACTGAACAGAGACCCTGGAGTATATGTGCTTGTGTGTGCTGGGGCCAGGGAGGGGCAGAGAAAGCACACACACGGAGCTTTGGTCACCAGTATCGTGGTGGGCGTCTTGATTAAAAATAGCCAAACTCCCAAACAATCTCTTCTAAATGGATGGGTGGGTAAATGAGGCTCCAGCCGCCACCCCCTGCTGACCTTCCTGTGACACTAAATGACAAGCCCATGAACCTGGATTTTAAGCTTGAATTGCCTACAAGCCCAGGGAGGCATACATTCTCCAACAAGCAGTGGGAAGATGTACCCAATTACTGATTGCCCTGTGTCCTTTCATAATGATACAGAAATTCCCTGCAATATAATGGATGAGGAGGTTATCAGAATTGAGAGAAGAGGTGATTGATTTTTGCTGAAATAGGATTAAAAGCTGATTACTTAACATGTGTGCAGAATAGTAAAACCTGGCCCAGTGATGACAAGCTCATCATCCCTCTGGGTGATGGGGGCAGTCAGCCCTCCCCGGAGCTTGGCACTGCCCCAGACACAGGTGAGAGATGTGCTGGGAGTGTGGCCTGCAGAAACACACATAACCTATGTGGTCCCGGGAAGGAACAAGGGACCGTTCATGAGAAATGCCATAGACTCAATAGAAACGGAACCAGCTCTGCACTGTTCTCAAGCTGGATTGGAAATGAGGGTGCAATCAACCTGGAGGTCAGGAAGATGAATCTGGAATCCCTCAACCCAGCTCTGACCGGCAGGCAGCTAAGGGAATGTCAGTGACAATCCTTCAGAACTGGATCCCCTCCCCACTTCTAGATGGGGCTAGGACTGTTTTAGAATACTCTGGATTAATGGAGTATGACTTATGAAACCAACACCCTTTTCTTCAGGGAATAATAGAGCAATGTTCAACATGAGAAAAGGCATGCTTGGTGTAAAAAGGTGGTCATTACATGATTGGTCATTGTGAAGGATGCGTCAAAAGTTGATGTGGCGGCCGGGCATGGTGGCTCATGCCTGCAATCCCAGCACTTTGAGAGGCTGAGGCAGGAGGACCACTTGAGGCCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAG
Task1_train_22436
Here is a mutation in XYLT1 (xylosyltransferase 1) on Chromosome 16. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Desbuquois dysplasia 2
CTCCCTAAGGGAAGCTGTTGGGGAATCTGTGTCTGCCCGTTACAAGTTAATGGGCACAGCCTTCTGATTTCTTCTAAACCAGTCCTCTTGAAGTGGTCTGGGAGAAGGGAGGGAAGGCAGAGATGCAGGAGGTGGGACTGAACAGAGACCCTGGAGTATATGTGCTTGTGTGTGCTGGGGCCAGGGAGGGGCAGAGAAAGCACACACACGGAGCTTTGGTCACCAGTATCGTGGTGGGCGTCTTGATTAAAAATAGCCAAACTCCCAAACAATCTCTTCTAAATGGATGGGTGGGTAAATGAGGCTCCAGCCGCCACCCCCTGCTGACCTTCCTGTGACACTAAATGACAAGCCCATGAACCTGGATTTTAAGCTTGAATTGCCTACAAGCCCAGGGAGGCATACATTCTCCAACAAGCAGTGGGAAGATGTACCCAATTACTGATTGCCCTGTGTCCTTTCATAATGATACAGAAATTCCCTGCAATATAATGGATGAGGAGGTTATCAGAATTGAGAGAAGAGGTGATTGATTTTTGCTGAAATAGGATTAAAAGCTGATTACTTAACATGTGTGCAGAATAGTAAAACCTGGCCCAGTGATGACAAGCTCATCATCCCTCTGGGTGATGGGGGCAGTCAGCCCTCCCCGGAGCTTGGCACTGCCCCAGACACAGGTGAGAGATGTGCTGGGAGTGTGGCCTGCAGAAACACACATAACCTATGTGGTCCCGGGAAGGAACAAGGGACCGTTCATGAGAAATGCCATAGACTCAATAGAAACGGAACCAGCTCTGCACTGTTCTCAAGCTGGATTGGAAATGAGGGTGCAATCAACCTGGAGGTCAGGAAGATGAATCTGGAATCCCTCAACCCAGCTCTGACCGGCAGGCAGCTAAGGGAATGTCAGTGACAATCCTTCAGAACTGGATCCCCTCCCCACTTCTAGATGGGGCTAGGACTGTTTTAGAATACTCTGGATTAATGGAGTATGACTTATGAAACCAACACCCTTTTCTTCAGGGAATAATAGAGCAATGTTCAACATGAGAAAAGGCATGCTTGGTGTAAAAAGGTGGTCATTACATGATTGGTCATTGTGAAGGATGCGTCAAAAGTTGATGTGGCGGCCGGGCATGGTGGCTCATGCCTGCAATCCCAGCACTTTGAGAGGCTGAGGCAGGAGGACCACTTGAGGCCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGGGCGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGCAGAATTGCTTGAACTCTGGAGGTAGAGGTTGCAGTGAGCAGAGACTGTGCCACTGCAGTCCAGCCTGGATGACAGAGGAAGACTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTTGATGTGGGTGTGTCCTGAAAGGGTCAGCATATACAGTTGTGCAGGTTACACACTACATACCTTTTAGGGGTGCCATCAGCATTGTGGATGTCAGAAGGGTTTTTTAAATAACAGTTTTCTGGAAAATAGCCATAAGGTTCTTGTTCTAACAAAATCTGTGTATCATGTGATTTTTATGACCAATGAAAGCCAAGTATCTTGAGGAAGAGCTGCCTTTTCTATTTTGCACAAAGACACTGTGTGGACTGCCGGTGGTAGCACCGTGTGTCTACTCCACGCAGCCTCTGTGCAGACTGGAGGGAGACCAGGCATCCTGCTAAGACAGCAAGGATGTCTGGGTGTGTAGAGGACAATGTAGGTGGACCCAGAATCTCTTTGCCAAAAATTCAGCATCTGCTTTGCCACAAAGGCTAGAACAAGCCCCTATCTTTCTTGGGAAAATTTTCCCAGATACTCACCTCAGCAGGAAGCAGGGTGTAGGAGTAGAACTGTTTCATCTTGGTCACCAGATCGTCTGTGGAGAAGGTCACATATTCTACAAACCTCCGGTTCAGCAGGAACCAGTCCGAACCGCCATCCACGGCAATGCCCTCTGGGATCCGCCGATCTCCCAGGCGCCACATGTGAGCGTCGCACTCCAGGAAGAGCCGATCCAGGCCCTGCTTCCGAATGAACCTGGGAGGGAGAAAGCTGCCCTTAGCCCAGAGGTGTCCTGAAAGACAGAACTCCAGCCAGAGTCCAAATAAAACAACACAATCATAGCGATGATGGCAATTATTGAGTGCCTGCTGTGTGCCAGGTACTGCTCCAGGGCTCTGCGTGGAGTTTATCACTTGATCCCCACAAGTGAGGCATGTCACCGTATTTACCCCTATGACGCAGGTACTATTTGACCCCCAACTTTCATATGAGGGCACTGAGGCTTAGAGAGCCCAGGGGACTTACCCAGCACAGTCAGATGACAGTGATCATCTGCTACAGCTACTCCTTCTCTAGAGAACTTTGGCAACAACCTCCTTATGCCATAGAGGTCTTGGCAGTTTAGTGAATGCAGACCATGGACCCTTGTCTCAGAATAGTACTCTTCAATGCATACAACAAAATATACAGGGTTATGAAACAGCGAAAAATAAAAATCCACCAAAGTTCTGATATAAAGTAATGCCTGTGCTTCTTGACTCACACATTATATACAGGATTACAACATTTTTAAAATTTTTATTTTTTGAGACAGGGTCGTGTTCCGTTGCCTAGGCTGGAGAGCACTAGTGTGATCCTAGCTCCCCGCAGCCTCAAACTCCTGGGCTCCTGTGACCCTCCTGCCTCCAGCTCCTGAGTAGCTAGGACTACAGGCATGCATCACCATGTTTGGCTGATTTTTAAAATTATTTTTGTAGAGATGGGATCTTACTATGTTGCCTAGACTGGTCTTGAACTTCTGGCTTCAGGCTCCCAAAGCACTGGGATTACAGGCATGCACCGCCATGTCTGGCTGCTGCTTAAATTTTTTTGTAGAGACAGGGTCTCACGATGTTGCTTAGGCTGGCGTAAAACTCCTGGCCTCAAGCAATCCTCCCACCTTGGCCTCTCAAAGTGCTGGGATTATAGGTGTGAGCTACTGCATGGGGCCTGGATTACAAAATACATTTTAAAACACTGAATGTATGGTACTACGTGTGTTTCTTTATTAATACATTAAATAACAAGATATCATGGCAGGTCTATTAAATCCTGTAATTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCGGTAGCTCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACAGTAACCTCCGCTTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACACACCACCTCACCCAGCTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGCCTTGAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCACAGAGTGCTGGGGTTATAGGTGTAAGCCATTGCGCCTGGCCTAACTCCTGAAATTTTGAAGTAGTGGTGAGCATAAATGATATTTAGAGGTATCTGCACCAACTATAATGTGACAGGAAAATAGATGATTCCTACTGGTGACCGAGTCAGTTAGTTACTGCTAATACTACTGTGATTTGTTACCTACCTTTAGCTAGATTTCAGTTAGAATTCCATTAAAAAAGATATCATTTTCTTCTCATCCAAAATCACGAACCTCCCCTGAATTTTTCCCATGAACCCTAGATTAATAACTCCTACTGTAGTAACTATATACATATAATCATCTTGTTTAGAATTTTGCAAGGCAGGCTGGGCAGAGTTGGCATTTCCTATTTTGTAGATGCAGAAACCAAAGCTGTTCAGGTCCCAGAGCTGGTGACGTGGGCATGTTGGGAGGGTGGACAGAGCTAGAACCAAGGCTTTTGGGCCAAACGCTCAGTCCATTAGCAATTAGCATTCATTGCACACATAACCATCATTGCCATTACCATCATCACCATTTTCATTATCATCACTGTCACTGCCACCATCATCATCATCTCCATCTTCATTATCAGCACCACTATCACCATTTTCACGTATTACGTGCCAGGTACTGTGCTG
CTCCCTAAGGGAAGCTGTTGGGGAATCTGTGTCTGCCCGTTACAAGTTAATGGGCACAGCCTTCTGATTTCTTCTAAACCAGTCCTCTTGAAGTGGTCTGGGAGAAGGGAGGGAAGGCAGAGATGCAGGAGGTGGGACTGAACAGAGACCCTGGAGTATATGTGCTTGTGTGTGCTGGGGCCAGGGAGGGGCAGAGAAAGCACACACACGGAGCTTTGGTCACCAGTATCGTGGTGGGCGTCTTGATTAAAAATAGCCAAACTCCCAAACAATCTCTTCTAAATGGATGGGTGGGTAAATGAGGCTCCAGCCGCCACCCCCTGCTGACCTTCCTGTGACACTAAATGACAAGCCCATGAACCTGGATTTTAAGCTTGAATTGCCTACAAGCCCAGGGAGGCATACATTCTCCAACAAGCAGTGGGAAGATGTACCCAATTACTGATTGCCCTGTGTCCTTTCATAATGATACAGAAATTCCCTGCAATATAATGGATGAGGAGGTTATCAGAATTGAGAGAAGAGGTGATTGATTTTTGCTGAAATAGGATTAAAAGCTGATTACTTAACATGTGTGCAGAATAGTAAAACCTGGCCCAGTGATGACAAGCTCATCATCCCTCTGGGTGATGGGGGCAGTCAGCCCTCCCCGGAGCTTGGCACTGCCCCAGACACAGGTGAGAGATGTGCTGGGAGTGTGGCCTGCAGAAACACACATAACCTATGTGGTCCCGGGAAGGAACAAGGGACCGTTCATGAGAAATGCCATAGACTCAATAGAAACGGAACCAGCTCTGCACTGTTCTCAAGCTGGATTGGAAATGAGGGTGCAATCAACCTGGAGGTCAGGAAGATGAATCTGGAATCCCTCAACCCAGCTCTGACCGGCAGGCAGCTAAGGGAATGTCAGTGACAATCCTTCAGAACTGGATCCCCTCCCCACTTCTAGATGGGGCTAGGACTGTTTTAGAATACTCTGGATTAATGGAGTATGACTTATGAAACCAACACCCTTTTCTTCAGGGAATAATAGAGCAATGTTCAACATGAGAAAAGGCATGCTTGGTGTAAAAAGGTGGTCATTACATGATTGGTCATTGTGAAGGATGCGTCAAAAGTTGATGTGGCGGCCGGGCATGGTGGCTCATGCCTGCAATCCCAGCACTTTGAGAGGCTGAGGCAGGAGGACCACTTGAGGCCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGGGCGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGCAGAATTGCTTGAACTCTGGAGGTAGAGGTTGCAGTGAGCAGAGACTGTGCCACTGCAGTCCAGCCTGGATGACAGAGGAAGACTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTTGATGTGGGTGTGTCCTGAAAGGGTCAGCATATACAGTTGTGCAGGTTACACACTACATACCTTTTAGGGGTGCCATCAGCATTGTGGATGTCAGAAGGGTTTTTTAAATAACAGTTTTCTGGAAAATAGCCATAAGGTTCTTGTTCTAACAAAATCTGTGTATCATGTGATTTTTATGACCAATGAAAGCCAAGTATCTTGAGGAAGAGCTGCCTTTTCTATTTTGCACAAAGACACTGTGTGGACTGCCGGTGGTAGCACCGTGTGTCTACTCCACGCAGCCTCTGTGCAGACTGGAGGGAGACCAGGCATCCTGCTAAGACAGCAAGGATGTCTGGGTGTGTAGAGGACAATGTAGGTGGACCCAGAATCTCTTTGCCAAAAATTCAGCATCTGCTTTGCCACAAAGGCTAGAACAAGCCCCTATCTTTCTTGGGAAAATTTTCCCAGATACTCACCTCAGCAGGAAGCAGGGTGTAGGAGTAGAACTGTTTCATCTTGGTCACCAGATCGTCTGTGGAGAAGGTCACATATTCTACAAACCTCCGGTTCAGCAGGAACCAGTCCGAACCGCCATCCACGGCAATGCCCTCTGGGATCCGCCAATCTCCCAGGCGCCACATGTGAGCGTCGCACTCCAGGAAGAGCCGATCCAGGCCCTGCTTCCGAATGAACCTGGGAGGGAGAAAGCTGCCCTTAGCCCAGAGGTGTCCTGAAAGACAGAACTCCAGCCAGAGTCCAAATAAAACAACACAATCATAGCGATGATGGCAATTATTGAGTGCCTGCTGTGTGCCAGGTACTGCTCCAGGGCTCTGCGTGGAGTTTATCACTTGATCCCCACAAGTGAGGCATGTCACCGTATTTACCCCTATGACGCAGGTACTATTTGACCCCCAACTTTCATATGAGGGCACTGAGGCTTAGAGAGCCCAGGGGACTTACCCAGCACAGTCAGATGACAGTGATCATCTGCTACAGCTACTCCTTCTCTAGAGAACTTTGGCAACAACCTCCTTATGCCATAGAGGTCTTGGCAGTTTAGTGAATGCAGACCATGGACCCTTGTCTCAGAATAGTACTCTTCAATGCATACAACAAAATATACAGGGTTATGAAACAGCGAAAAATAAAAATCCACCAAAGTTCTGATATAAAGTAATGCCTGTGCTTCTTGACTCACACATTATATACAGGATTACAACATTTTTAAAATTTTTATTTTTTGAGACAGGGTCGTGTTCCGTTGCCTAGGCTGGAGAGCACTAGTGTGATCCTAGCTCCCCGCAGCCTCAAACTCCTGGGCTCCTGTGACCCTCCTGCCTCCAGCTCCTGAGTAGCTAGGACTACAGGCATGCATCACCATGTTTGGCTGATTTTTAAAATTATTTTTGTAGAGATGGGATCTTACTATGTTGCCTAGACTGGTCTTGAACTTCTGGCTTCAGGCTCCCAAAGCACTGGGATTACAGGCATGCACCGCCATGTCTGGCTGCTGCTTAAATTTTTTTGTAGAGACAGGGTCTCACGATGTTGCTTAGGCTGGCGTAAAACTCCTGGCCTCAAGCAATCCTCCCACCTTGGCCTCTCAAAGTGCTGGGATTATAGGTGTGAGCTACTGCATGGGGCCTGGATTACAAAATACATTTTAAAACACTGAATGTATGGTACTACGTGTGTTTCTTTATTAATACATTAAATAACAAGATATCATGGCAGGTCTATTAAATCCTGTAATTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCGGTAGCTCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACAGTAACCTCCGCTTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACACACCACCTCACCCAGCTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGCCTTGAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCACAGAGTGCTGGGGTTATAGGTGTAAGCCATTGCGCCTGGCCTAACTCCTGAAATTTTGAAGTAGTGGTGAGCATAAATGATATTTAGAGGTATCTGCACCAACTATAATGTGACAGGAAAATAGATGATTCCTACTGGTGACCGAGTCAGTTAGTTACTGCTAATACTACTGTGATTTGTTACCTACCTTTAGCTAGATTTCAGTTAGAATTCCATTAAAAAAGATATCATTTTCTTCTCATCCAAAATCACGAACCTCCCCTGAATTTTTCCCATGAACCCTAGATTAATAACTCCTACTGTAGTAACTATATACATATAATCATCTTGTTTAGAATTTTGCAAGGCAGGCTGGGCAGAGTTGGCATTTCCTATTTTGTAGATGCAGAAACCAAAGCTGTTCAGGTCCCAGAGCTGGTGACGTGGGCATGTTGGGAGGGTGGACAGAGCTAGAACCAAGGCTTTTGGGCCAAACGCTCAGTCCATTAGCAATTAGCATTCATTGCACACATAACCATCATTGCCATTACCATCATCACCATTTTCATTATCATCACTGTCACTGCCACCATCATCATCATCTCCATCTTCATTATCAGCACCACTATCACCATTTTCACGTATTACGTGCCAGGTACTGTGCTG
Task1_train_22437
A variant has been detected on Chromosome 16 in COQ7 (coenzyme Q7, hydroxylase). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Primary coenzyme Q10 deficiency 8
GATTTCGCAGTTCAGGAATGACTTTAGACAATATCAGTCGGGCAGCTGTGGATCGAATAATCCGGGTGGATCATGCAGGCGAATATGGAGCAAACCGCATCTATGCCGGGCAGATGGCTGTCCTGGGTCGGACCAGCGTCGGGCCAGTCATTCAGGTGGGTGCTTCTTCATCTCCCTCACCCTGGTCTACTGAATGGGCAGATCCAAAGGACTTCAAGTAATGAATCATGGGAGGTCAAGCGTTCCCTAGGGAGATGCCATTGTCTCCAGGAGAGCGAAGGTTGGTTCTTGGTGGAGATGGGGAGCAAAAAGCATATTGTTCTTTTTATGGATAAAGCACAGAGAGACATCTAGTACATAGACAGGTATGCGGTATATCTTTGGTATCAGTACTCCATGGCGGGGGCAGGCAGTAATGAAAAAAGGTTAAGAATCGCTCAGCACAGCAGTCAACTGTGCTGAAATGTTGCAGCCCTGCCCCCTACCGTGCCAGAGAGGTATTGTATCCCAAGAGGCTATGGGAGGACCTGAAATTTGTAGTTACACAGACCTGGTTCACATTTTGGCTCTCTCCCACCTCCTACCTGTGCGACCTTGAGGATGGCACAGGACTTCTCTGGGTTTCCATTTCCGTATCTGCAAAATGGCCTCATAATGGCCTGGGTTTGGGTAAGGAACCGGGTCTGGCCCATAAAGGTCAAGTTAGTACAAGTTAAATGGCCTGCCCTGAACCCTTGGGCAAGCTACTTAGCCTCTCTGTGCTTCAGTTTGTTGTGTATACTGGCGCAGTCATAGTGTGTCCTTCACAGGGATTGTGTGGATTGAATGAATTGCTTGCATGAAGCTATTTGATGGCCCCTGGCACTTAGGACGTGCCATCTAAGTGTTAGCTGCAGCTAGCATTCTCCCTTTTTCCTCTGATGTAAATAATATTCAGGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCCAATGGATCGCTTGAGCCCAGGAGTTTGAGACCAGCTTGGGCAATGTGATGAGACTCCGTCTCTACGAAAAATACAAAAATTAGCTGGGTGCAATGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCTGTGGCGGGTGGATCACCTGAGGTTAGGAGTTTGAGATCAGCCTGGCCAACAAGGCAAAACCCTGTCTCTACTAAAAATACAAAACAAATCAGCCAGGCATGGTGGTGCATGCCTGTAGTCCCAGCTGCTTGGGAGGCTGAGGCAAGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGGGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTCAAAAAAACAAAAAAAACCGCACACACACCACAAAATTAGCCAGGTGTAGTGGCATGTGACTGTAATCCCAGCTAATTTGAGAGGCCGAGGTGGGAGGATCGCTTGATCCTGGAGGTTGAGGCTGCGGTGAGCCATGAGCTTGCTACTGCACTACAGTCTGGGTGACAGAGTGAGACCCTGTCTGGAAACAAACAAACCACAACAACAACAAGATGATGCTATTCTAGTAATCTGGAAGGAAATTACACAACAGCCAATGTTCTGCCTTCCTGATTTTGAAATGGGTTAAACATGTCATTTCTTATGTGTGTAGACCCTTGTCATTTACTGGGCACATTGTGGGCCTGAGAGACTTCTGCTGCAACCATGGCTCATGGCAGTCTTAACTGGAATTGAGATAATAGACTGTTTTGTATTCTTGGTGCTCTCTTCTCTTTGTCACAGATTCCTTTAGTCTGATGTTTTACTGTTTCCATTGACGTTTTGAGGGGAATGGGGGAGACAGCAGTTCCATCATTTTCTCCGTTTCTGCTTTGCTCCCTGTATGCCGCTTGGATGAGTGGGAGGCCTCTATGGAATGCTTGCATGTCTTTATTTTTATGTTTCTTGCAGAAAATGTGGGATCAAGAAAAGGACCATTTGAAAAAGTTCAATGAGTTGATGGTTACGTTCAGGGTCCGGCCAACAGTTCTGATGCCCTTGTGGAACGTGCTGGGGTTTGCACTGGGTACGTGTCTCTCTAGAAGAGCTTATGCAAGCTTGGGGATCTAGGATGATTAAATCCTTCAGGTATCATGTTCACAATTCTTGCTGTGTCCTCTTATGACCTCATTCTGTTTACTTCATATTTTTCCGAGGTTAAATTGACTGCCTTTTTTTGTGTGTGGTTAAATTTATTTAAGATAGAATCTTAATGTCAGTACTTTAAAAAAAAAGGCCGGGCGTGATGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCATGAGGTCAGGAGTTCGAGACCAGCCTGAACAACATGGTGAAACCCCCGACTCTATTAAAAATACAAAAATTAGCCGGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCCAGAGAATCGCTTGAACCTGGGAGCTGGAGGTTGCAGTGAGCCAAGATTGGCCCACTGCACTCCAGCGTGGGTGACAGAGCGACACTCTGTCTCAAAAAAAAACCAAAACAAAACAAAAAAAAACAAACCAGAGCCAGGGTCTCACTCTGTTGCCCAGGCTGGAGTACAGTGGTATAGTCGTAGCTCACTGAAACCTCAAACTCTTGGGTTCAAGTGATCCTCCCACCTAAGCCTCTGAGCCTGAGTATCTTGGACTACTGGCGCATGCCACCACGCACAGCTCTATTTTTTTTGTAGAGATGGGGTCTCGTTATGTTACCTAGGCTGGTCTCAAACTGCTGGCCTCAAGCCATCTTCCCTCTCTGGCCTCCCCGAAGTGCTAGGATTACAGGCGTGAGGCACTGCACCTGGCCTAATGTCAGTATTATAAATAGAAAATACAGTAAAAATAAACAACAGAGAAAAAAAGCTAGTAGAATTCAGTTGCAGCCAAATACTGTTCCCTGACAACGATTCTCAACCTGAGATCTGTTCACTCTTTTAAAAAACGGAGAAGAATAAATGGTATAAAAGATCAAAGATATACTCACCCCAAATGCTGACTTCTCTTGGCCACGGTCAGGATAAAACAGCATTGAAAAGAGAATGGTTTTTCTTAACTGTGTAATTCCAGGTTTAACACTGGGATCCAGTGTCTCCTAAAACAGTGGTTCTCCCTCAGGGTGAGTTTGTCCCCCTGATGAGGACATGTGGCAATACCTAGGGACATTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGTTCTGTCACCCACGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCCGGCTTCAAGCGATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCCCACCACCACACTGACTAATTTTTGTATTTTTAGTAGAGACGGTTTCACCATGTTAGCCAGGTTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTCGGCCTCCCAAAGTGCTGGGACTATAGGCGTGATCCATTGTGCCCAGCCCTCGGGACAGTTTTGATTGTCAAAACTTAGTTGGCACTGCTGGCATCTAGTTGGTAGAGGTCAGAGATGCAGTTAAATATCCCACCATGCATGGGACAGCCCCTGTCACAAAGAATGACCCGGCCCGATGTCTGGTGCAGAGGTTAAGAAGCCCTGGCCACAGATGGTCTCCATTACCGGTCATATCTGTCTCTTACTTTTCTGGTCTGGGTTTAACAATCCCAGGGGCGGGGACCGCCTTGCTCGGGAAGGAAGGTGCCATGGCCTGCACCGTGGCGGTGGAAGAGAGCATAGCACATCACTACAACAACCAGATCAGGACGCTGATGGAGGAGGACCCTGAAAAATACGAGGAACTTCTTCAGGTATTTATCCGTGCTCTAGAACGGGGCTGCTCAAGGAGGAAAATGGCAGATAGCAATTGGGTAAGAGGAAAACATGTTAGAGATTGTTAGGGGATGATGGGGGTTTAGAGGCTCAGGTCAGTGCCTCAGTTTAAAGGTGAGCAAACTGAGGAACAGAGAGGTGAACCCGTCTGCCCTGGCCATACAG
GATTTCGCAGTTCAGGAATGACTTTAGACAATATCAGTCGGGCAGCTGTGGATCGAATAATCCGGGTGGATCATGCAGGCGAATATGGAGCAAACCGCATCTATGCCGGGCAGATGGCTGTCCTGGGTCGGACCAGCGTCGGGCCAGTCATTCAGGTGGGTGCTTCTTCATCTCCCTCACCCTGGTCTACTGAATGGGCAGATCCAAAGGACTTCAAGTAATGAATCATGGGAGGTCAAGCGTTCCCTAGGGAGATGCCATTGTCTCCAGGAGAGCGAAGGTTGGTTCTTGGTGGAGATGGGGAGCAAAAAGCATATTGTTCTTTTTATGGATAAAGCACAGAGAGACATCTAGTACATAGACAGGTATGCGGTATATCTTTGGTATCAGTACTCCATGGCGGGGGCAGGCAGTAATGAAAAAAGGTTAAGAATCGCTCAGCACAGCAGTCAACTGTGCTGAAATGTTGCAGCCCTGCCCCCTACCGTGCCAGAGAGGTATTGTATCCCAAGAGGCTATGGGAGGACCTGAAATTTGTAGTTACACAGACCTGGTTCACATTTTGGCTCTCTCCCACCTCCTACCTGTGCGACCTTGAGGATGGCACAGGACTTCTCTGGGTTTCCATTTCCGTATCTGCAAAATGGCCTCATAATGGCCTGGGTTTGGGTAAGGAACCGGGTCTGGCCCATAAAGGTCAAGTTAGTACAAGTTAAATGGCCTGCCCTGAACCCTTGGGCAAGCTACTTAGCCTCTCTGTGCTTCAGTTTGTTGTGTATACTGGCGCAGTCATAGTGTGTCCTTCACAGGGATTGTGTGGATTGAATGAATTGCTTGCATGAAGCTATTTGATGGCCCCTGGCACTTAGGACGTGCCATCTAAGTGTTAGCTGCAGCTAGCATTCTCCCTTTTTCCTCTGATGTAAATAATATTCAGGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCCAATGGATCGCTTGAGCCCAGGAGTTTGAGACCAGCTTGGGCAATGTGATGAGACTCCGTCTCTACGAAAAATACAAAAATTAGCTGGGTGCAATGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCTGTGGCGGGTGGATCACCTGAGGTTAGGAGTTTGAGATCAGCCTGGCCAACAAGGCAAAACCCTGTCTCTACTAAAAATACAAAACAAATCAGCCAGGCATGGTGGTGCATGCCTGTAGTCCCAGCTGCTTGGGAGGCTGAGGCAAGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGGGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTCAAAAAAACAAAAAAAACCGCACACACACCACAAAATTAGCCAGGTGTAGTGGCATGTGACTGTAATCCCAGCTAATTTGAGAGGCCGAGGTGGGAGGATCGCTTGATCCTGGAGGTTGAGGCTGCGGTGAGCCATGAGCTTGCTACTGCACTACAGTCTGGGTGACAGAGTGAGACCCTGTCTGGAAACAAACAAACCACAACAACAACAAGATGATGCTATTCTAGTAATCTGGAAGGAAATTACACAACAGCCAATGTTCTGCCTTCCTGATTTTGAAATGGGTTAAACATGTCATTTCTTATGTGTGTAGACCCTTGTCATTTACTGGGCACATTGTGGGCCTGAGAGACTTCTGCTGCAACCATGGCTCATGGCAGTCTTAACTGGAATTGAGATAATAGACTGTTTTGTATTCTTGGTGCTCTCTTCTCTTTGTCACAGATTCCTTTAGTCTGATGTTTTACTGTTTCCATTGACGTTTTGAGGGGAATGGGGGAGACAGCAGTTCCATCATTTTCTCCGTTTCTGCTTTGCTCCCTGTATGCCGCTTGGATGAGTGGGAGGCCTCTATGGAATGCTTGCATGTCTTTATTTTTATGTTTCTTGCAGAAAATGTGGGATCAAGAAAAGGACCATTTGAAAAAGTTCAATGAGTTGATGGTTACGTTCAGGGTCCGGCCAACAGTTCCGATGCCCTTGTGGAACGTGCTGGGGTTTGCACTGGGTACGTGTCTCTCTAGAAGAGCTTATGCAAGCTTGGGGATCTAGGATGATTAAATCCTTCAGGTATCATGTTCACAATTCTTGCTGTGTCCTCTTATGACCTCATTCTGTTTACTTCATATTTTTCCGAGGTTAAATTGACTGCCTTTTTTTGTGTGTGGTTAAATTTATTTAAGATAGAATCTTAATGTCAGTACTTTAAAAAAAAAGGCCGGGCGTGATGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCATGAGGTCAGGAGTTCGAGACCAGCCTGAACAACATGGTGAAACCCCCGACTCTATTAAAAATACAAAAATTAGCCGGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCCAGAGAATCGCTTGAACCTGGGAGCTGGAGGTTGCAGTGAGCCAAGATTGGCCCACTGCACTCCAGCGTGGGTGACAGAGCGACACTCTGTCTCAAAAAAAAACCAAAACAAAACAAAAAAAAACAAACCAGAGCCAGGGTCTCACTCTGTTGCCCAGGCTGGAGTACAGTGGTATAGTCGTAGCTCACTGAAACCTCAAACTCTTGGGTTCAAGTGATCCTCCCACCTAAGCCTCTGAGCCTGAGTATCTTGGACTACTGGCGCATGCCACCACGCACAGCTCTATTTTTTTTGTAGAGATGGGGTCTCGTTATGTTACCTAGGCTGGTCTCAAACTGCTGGCCTCAAGCCATCTTCCCTCTCTGGCCTCCCCGAAGTGCTAGGATTACAGGCGTGAGGCACTGCACCTGGCCTAATGTCAGTATTATAAATAGAAAATACAGTAAAAATAAACAACAGAGAAAAAAAGCTAGTAGAATTCAGTTGCAGCCAAATACTGTTCCCTGACAACGATTCTCAACCTGAGATCTGTTCACTCTTTTAAAAAACGGAGAAGAATAAATGGTATAAAAGATCAAAGATATACTCACCCCAAATGCTGACTTCTCTTGGCCACGGTCAGGATAAAACAGCATTGAAAAGAGAATGGTTTTTCTTAACTGTGTAATTCCAGGTTTAACACTGGGATCCAGTGTCTCCTAAAACAGTGGTTCTCCCTCAGGGTGAGTTTGTCCCCCTGATGAGGACATGTGGCAATACCTAGGGACATTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGTTCTGTCACCCACGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCCGGCTTCAAGCGATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCCCACCACCACACTGACTAATTTTTGTATTTTTAGTAGAGACGGTTTCACCATGTTAGCCAGGTTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTCGGCCTCCCAAAGTGCTGGGACTATAGGCGTGATCCATTGTGCCCAGCCCTCGGGACAGTTTTGATTGTCAAAACTTAGTTGGCACTGCTGGCATCTAGTTGGTAGAGGTCAGAGATGCAGTTAAATATCCCACCATGCATGGGACAGCCCCTGTCACAAAGAATGACCCGGCCCGATGTCTGGTGCAGAGGTTAAGAAGCCCTGGCCACAGATGGTCTCCATTACCGGTCATATCTGTCTCTTACTTTTCTGGTCTGGGTTTAACAATCCCAGGGGCGGGGACCGCCTTGCTCGGGAAGGAAGGTGCCATGGCCTGCACCGTGGCGGTGGAAGAGAGCATAGCACATCACTACAACAACCAGATCAGGACGCTGATGGAGGAGGACCCTGAAAAATACGAGGAACTTCTTCAGGTATTTATCCGTGCTCTAGAACGGGGCTGCTCAAGGAGGAAAATGGCAGATAGCAATTGGGTAAGAGGAAAACATGTTAGAGATTGTTAGGGGATGATGGGGGTTTAGAGGCTCAGGTCAGTGCCTCAGTTTAAAGGTGAGCAAACTGAGGAACAGAGAGGTGAACCCGTCTGCCCTGGCCATACAG
Task1_train_22438
A variant was discovered on Chromosome 16, affecting COQ7 (coenzyme Q7, hydroxylase). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Primary coenzyme Q10 deficiency 8
TTGGTGCTCTCTTCTCTTTGTCACAGATTCCTTTAGTCTGATGTTTTACTGTTTCCATTGACGTTTTGAGGGGAATGGGGGAGACAGCAGTTCCATCATTTTCTCCGTTTCTGCTTTGCTCCCTGTATGCCGCTTGGATGAGTGGGAGGCCTCTATGGAATGCTTGCATGTCTTTATTTTTATGTTTCTTGCAGAAAATGTGGGATCAAGAAAAGGACCATTTGAAAAAGTTCAATGAGTTGATGGTTACGTTCAGGGTCCGGCCAACAGTTCTGATGCCCTTGTGGAACGTGCTGGGGTTTGCACTGGGTACGTGTCTCTCTAGAAGAGCTTATGCAAGCTTGGGGATCTAGGATGATTAAATCCTTCAGGTATCATGTTCACAATTCTTGCTGTGTCCTCTTATGACCTCATTCTGTTTACTTCATATTTTTCCGAGGTTAAATTGACTGCCTTTTTTTGTGTGTGGTTAAATTTATTTAAGATAGAATCTTAATGTCAGTACTTTAAAAAAAAAGGCCGGGCGTGATGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCATGAGGTCAGGAGTTCGAGACCAGCCTGAACAACATGGTGAAACCCCCGACTCTATTAAAAATACAAAAATTAGCCGGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCCAGAGAATCGCTTGAACCTGGGAGCTGGAGGTTGCAGTGAGCCAAGATTGGCCCACTGCACTCCAGCGTGGGTGACAGAGCGACACTCTGTCTCAAAAAAAAACCAAAACAAAACAAAAAAAAACAAACCAGAGCCAGGGTCTCACTCTGTTGCCCAGGCTGGAGTACAGTGGTATAGTCGTAGCTCACTGAAACCTCAAACTCTTGGGTTCAAGTGATCCTCCCACCTAAGCCTCTGAGCCTGAGTATCTTGGACTACTGGCGCATGCCACCACGCACAGCTCTATTTTTTTTGTAGAGATGGGGTCTCGTTATGTTACCTAGGCTGGTCTCAAACTGCTGGCCTCAAGCCATCTTCCCTCTCTGGCCTCCCCGAAGTGCTAGGATTACAGGCGTGAGGCACTGCACCTGGCCTAATGTCAGTATTATAAATAGAAAATACAGTAAAAATAAACAACAGAGAAAAAAAGCTAGTAGAATTCAGTTGCAGCCAAATACTGTTCCCTGACAACGATTCTCAACCTGAGATCTGTTCACTCTTTTAAAAAACGGAGAAGAATAAATGGTATAAAAGATCAAAGATATACTCACCCCAAATGCTGACTTCTCTTGGCCACGGTCAGGATAAAACAGCATTGAAAAGAGAATGGTTTTTCTTAACTGTGTAATTCCAGGTTTAACACTGGGATCCAGTGTCTCCTAAAACAGTGGTTCTCCCTCAGGGTGAGTTTGTCCCCCTGATGAGGACATGTGGCAATACCTAGGGACATTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGTTCTGTCACCCACGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCCGGCTTCAAGCGATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCCCACCACCACACTGACTAATTTTTGTATTTTTAGTAGAGACGGTTTCACCATGTTAGCCAGGTTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTCGGCCTCCCAAAGTGCTGGGACTATAGGCGTGATCCATTGTGCCCAGCCCTCGGGACAGTTTTGATTGTCAAAACTTAGTTGGCACTGCTGGCATCTAGTTGGTAGAGGTCAGAGATGCAGTTAAATATCCCACCATGCATGGGACAGCCCCTGTCACAAAGAATGACCCGGCCCGATGTCTGGTGCAGAGGTTAAGAAGCCCTGGCCACAGATGGTCTCCATTACCGGTCATATCTGTCTCTTACTTTTCTGGTCTGGGTTTAACAATCCCAGGGGCGGGGACCGCCTTGCTCGGGAAGGAAGGTGCCATGGCCTGCACCGTGGCGGTGGAAGAGAGCATAGCACATCACTACAACAACCAGATCAGGACGCTGATGGAGGAGGACCCTGAAAAATACGAGGAACTTCTTCAGGTATTTATCCGTGCTCTAGAACGGGGCTGCTCAAGGAGGAAAATGGCAGATAGCAATTGGGTAAGAGGAAAACATGTTAGAGATTGTTAGGGGATGATGGGGGTTTAGAGGCTCAGGTCAGTGCCTCAGTTTAAAGGTGAGCAAACTGAGGAACAGAGAGGTGAACCCGTCTGCCCTGGCCATACAGCACAGACAGAGCTGGGACTAGAACCCTTGTCTCCTTTGTCTTTTTTCTTTTTATTTAGAGATGAGGTCTTGCTCCGTTGCCCAGGCCGGAGTACAGTGGCACAGTCATAGCTCACTGCATCTTCAAACTCTTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCGAGTAGCTATGGGACTACATACATAGCCACCACTCACAGCTAATTTTTTTTTTTTTTTTTTTTTTAAGAGATGGGGTCTCACTATGTTTTCCAGGCTGGTCTTGAATTTCTGAGCTCCAGTAGTCCTCTCTCCTCAGCTTCCCAAAGTGCTAGAATTATAGGCATGAACCACCACATCCGGCCAGAACCCTTGTCTCTTGAGCCCTGTCCTGTTCACTTATTTTATTTTTAATTTTTAAAATTTTTTGTAGGCACAGTCTCTCTCTATGTTGTCCAGATTGGTCTTGAGCTCCTGGGCTCAAGTGATTCTTCTGCCTCGGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACACCACCTGGTGCTGTTCACTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCCCCAAGGCTGGAGTGCAGTGGTCTCCGCCTGCATTGCAGCCTCCGCCTCCCGGGTTCCAGCGATTCTCCTGCCTCGGCGTCCCAGGTAGCTGGGATTACAGACATGCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTGGAACTCCTGACCTCAGGTGATCCTCCTGCCTTGGCCTCCTAAAGTGCTGGGATTGCAGGCGTGAGCCACCGCGCCCGGCCCACTTCTTTATCATTGGTAGATTCTGAGCAGATGCTGTGAGCAGGAACCCTTTAGATTGAATAAATGAATAGATATCCTGAGATAATTTTCCACAGCAAATAAGGGAACTGTTTAGTTTTTTAGAGTCTAAATCTGAGGTTGGCAAACTATGGCCTGTGGCCAGCCACCTGTTTCTTTAAATAAACTTTTATTGGAACACAAGCACGTCCATTTGTTTGCATGTCTCCGGCTGCTTTTCTGGTTACAGTGGCAGAGTTGGGTAGTTGCAACAAAGTATTTACTCTCTGGCCCTTTAGAGGAAAAGCTGGCCTCCCTGTCTTAGGCCATAATAAGAGGCTTTAGCCTCCAAAATGAAATGGAACAGCAGGAGAGTTGGAAGGCTAACTTGCTTTGGTGTCTTTTTATTTAACCAGCTGATAAAGAAATTTCGGGATGAAGAGCTTGAGCACCATGACATAGGCCTCGACCATGATGCAGAATTGGTAGGGCCCTACTGTTACCTGTTCTGCTTTGGGACTCCTTATTTGGGAGGCTGAAGGGGCAGGAGGTTTCTGTTGCCAGAAAAATACATTTTAAAGTGACAGCGAAAGGGAGAGAAAACCAATGACGTTGCTTTGACAAAAAGCAAGCAAACGCATTATTGCTCCAGATTGGGAATCTCCTTTCTTGCTTTATGCCTTCTCCTTTTCCCCAGAAGCTTTTTTTTTTTTTTCCCAGACACAGTCTCACTCTGTCTCCCATGCTGGAGTGCAGTGGTGCAGTCTTAGCTCACTGCAGCCTCCTCCTTCCAGGTTCAAGCAATTCTGCCTCAGCCTCCCAAGTAGCTGGGATGACAGGTGCATGCCACCATGCCTGGCTAATTTTTGTATTTTTTATTTTTAGTGGAGACCGAGTTTTCACTGTGTTGGCCAGGCTGGTCTCGAACTCCTG
TTGGTGCTCTCTTCTCTTTGTCACAGATTCCTTTAGTCTGATGTTTTACTGTTTCCATTGACGTTTTGAGGGGAATGGGGGAGACAGCAGTTCCATCATTTTCTCCGTTTCTGCTTTGCTCCCTGTATGCCGCTTGGATGAGTGGGAGGCCTCTATGGAATGCTTGCATGTCTTTATTTTTATGTTTCTTGCAGAAAATGTGGGATCAAGAAAAGGACCATTTGAAAAAGTTCAATGAGTTGATGGTTACGTTCAGGGTCCGGCCAACAGTTCTGATGCCCTTGTGGAACGTGCTGGGGTTTGCACTGGGTACGTGTCTCTCTAGAAGAGCTTATGCAAGCTTGGGGATCTAGGATGATTAAATCCTTCAGGTATCATGTTCACAATTCTTGCTGTGTCCTCTTATGACCTCATTCTGTTTACTTCATATTTTTCCGAGGTTAAATTGACTGCCTTTTTTTGTGTGTGGTTAAATTTATTTAAGATAGAATCTTAATGTCAGTACTTTAAAAAAAAAGGCCGGGCGTGATGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCATGAGGTCAGGAGTTCGAGACCAGCCTGAACAACATGGTGAAACCCCCGACTCTATTAAAAATACAAAAATTAGCCGGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCCAGAGAATCGCTTGAACCTGGGAGCTGGAGGTTGCAGTGAGCCAAGATTGGCCCACTGCACTCCAGCGTGGGTGACAGAGCGACACTCTGTCTCAAAAAAAAACCAAAACAAAACAAAAAAAAACAAACCAGAGCCAGGGTCTCACTCTGTTGCCCAGGCTGGAGTACAGTGGTATAGTCGTAGCTCACTGAAACCTCAAACTCTTGGGTTCAAGTGATCCTCCCACCTAAGCCTCTGAGCCTGAGTATCTTGGACTACTGGCGCATGCCACCACGCACAGCTCTATTTTTTTTGTAGAGATGGGGTCTCGTTATGTTACCTAGGCTGGTCTCAAACTGCTGGCCTCAAGCCATCTTCCCTCTCTGGCCTCCCCGAAGTGCTAGGATTACAGGCGTGAGGCACTGCACCTGGCCTAATGTCAGTATTATAAATAGAAAATACAGTAAAAATAAACAACAGAGAAAAAAAGCTAGTAGAATTCAGTTGCAGCCAAATACTGTTCCCTGACAACGATTCTCAACCTGAGATCTGTTCACTCTTTTAAAAAACGGAGAAGAATAAATGGTATAAAAGATCAAAGATATACTCACCCCAAATGCTGACTTCTCTTGGCCACGGTCAGGATAAAACAGCATTGAAAAGAGAATGGTTTTTCTTAACTGTGTAATTCCAGGTTTAACACTGGGATCCAGTGTCTCCTAAAACAGTGGTTCTCCCTCAGGGTGAGTTTGTCCCCCTGATGAGGACATGTGGCAATACCTAGGGACATTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGTTCTGTCACCCACGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCCGGCTTCAAGCGATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCCCACCACCACACTGACTAATTTTTGTATTTTTAGTAGAGACGGTTTCACCATGTTAGCCAGGTTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTCGGCCTCCCAAAGTGCTGGGACTATAGGCGTGATCCATTGTGCCCAGCCCTCGGGACAGTTTTGATTGTCAAAACTTAGTTGGCACTGCTGGCATCTAGTTGGTAGAGGTCAGAGATGCAGTTAAATATCCCACCATGCATGGGACAGCCCCTGTCACAAAGAATGACCCGGCCCGATGTCTGGTGCAGAGGTTAAGAAGCCCTGGCCACAGATGGTCTCCATTACCGGTCATATCTGTCTCTTACTTTTCTGGTCTGGGTTTAACAATCCCAGGGGCGGGGACCGCCTTGCTCGGGAAGGAAGGTGCCATGGCCTGCACCGTGGCGGAGGAAGAGAGCATAGCACATCACTACAACAACCAGATCAGGACGCTGATGGAGGAGGACCCTGAAAAATACGAGGAACTTCTTCAGGTATTTATCCGTGCTCTAGAACGGGGCTGCTCAAGGAGGAAAATGGCAGATAGCAATTGGGTAAGAGGAAAACATGTTAGAGATTGTTAGGGGATGATGGGGGTTTAGAGGCTCAGGTCAGTGCCTCAGTTTAAAGGTGAGCAAACTGAGGAACAGAGAGGTGAACCCGTCTGCCCTGGCCATACAGCACAGACAGAGCTGGGACTAGAACCCTTGTCTCCTTTGTCTTTTTTCTTTTTATTTAGAGATGAGGTCTTGCTCCGTTGCCCAGGCCGGAGTACAGTGGCACAGTCATAGCTCACTGCATCTTCAAACTCTTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCGAGTAGCTATGGGACTACATACATAGCCACCACTCACAGCTAATTTTTTTTTTTTTTTTTTTTTTAAGAGATGGGGTCTCACTATGTTTTCCAGGCTGGTCTTGAATTTCTGAGCTCCAGTAGTCCTCTCTCCTCAGCTTCCCAAAGTGCTAGAATTATAGGCATGAACCACCACATCCGGCCAGAACCCTTGTCTCTTGAGCCCTGTCCTGTTCACTTATTTTATTTTTAATTTTTAAAATTTTTTGTAGGCACAGTCTCTCTCTATGTTGTCCAGATTGGTCTTGAGCTCCTGGGCTCAAGTGATTCTTCTGCCTCGGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACACCACCTGGTGCTGTTCACTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCCCCAAGGCTGGAGTGCAGTGGTCTCCGCCTGCATTGCAGCCTCCGCCTCCCGGGTTCCAGCGATTCTCCTGCCTCGGCGTCCCAGGTAGCTGGGATTACAGACATGCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTGGAACTCCTGACCTCAGGTGATCCTCCTGCCTTGGCCTCCTAAAGTGCTGGGATTGCAGGCGTGAGCCACCGCGCCCGGCCCACTTCTTTATCATTGGTAGATTCTGAGCAGATGCTGTGAGCAGGAACCCTTTAGATTGAATAAATGAATAGATATCCTGAGATAATTTTCCACAGCAAATAAGGGAACTGTTTAGTTTTTTAGAGTCTAAATCTGAGGTTGGCAAACTATGGCCTGTGGCCAGCCACCTGTTTCTTTAAATAAACTTTTATTGGAACACAAGCACGTCCATTTGTTTGCATGTCTCCGGCTGCTTTTCTGGTTACAGTGGCAGAGTTGGGTAGTTGCAACAAAGTATTTACTCTCTGGCCCTTTAGAGGAAAAGCTGGCCTCCCTGTCTTAGGCCATAATAAGAGGCTTTAGCCTCCAAAATGAAATGGAACAGCAGGAGAGTTGGAAGGCTAACTTGCTTTGGTGTCTTTTTATTTAACCAGCTGATAAAGAAATTTCGGGATGAAGAGCTTGAGCACCATGACATAGGCCTCGACCATGATGCAGAATTGGTAGGGCCCTACTGTTACCTGTTCTGCTTTGGGACTCCTTATTTGGGAGGCTGAAGGGGCAGGAGGTTTCTGTTGCCAGAAAAATACATTTTAAAGTGACAGCGAAAGGGAGAGAAAACCAATGACGTTGCTTTGACAAAAAGCAAGCAAACGCATTATTGCTCCAGATTGGGAATCTCCTTTCTTGCTTTATGCCTTCTCCTTTTCCCCAGAAGCTTTTTTTTTTTTTTCCCAGACACAGTCTCACTCTGTCTCCCATGCTGGAGTGCAGTGGTGCAGTCTTAGCTCACTGCAGCCTCCTCCTTCCAGGTTCAAGCAATTCTGCCTCAGCCTCCCAAGTAGCTGGGATGACAGGTGCATGCCACCATGCCTGGCTAATTTTTGTATTTTTTATTTTTAGTGGAGACCGAGTTTTCACTGTGTTGGCCAGGCTGGTCTCGAACTCCTG
Task1_train_22439
The following genetic variant occurs in VPS35L (VPS35 endosomal protein sorting factor like) on Chromosome 16. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Ritscher-Schinzel syndrome 3
TACAATCCATTCAACATTATTCACCCAATGCATGTCAGTGCCCAGCACTGTCCCAGGAGCCAGAGACAGGGCGGGATTGAATGTCATCAGGGACACCATCCACATTGAGTTCCTGGAGGCGCCATTAACAGAATACAGTGTGCAGCCAGCAGACCTGGCGGTGTATTGGCAAATGCAATAGATGAAGTGCCTGTCCTCCTGGAGGTTATAGGCTAGCATGAAACAGAGAGAACCAGGAAAACCACGAGATATTGTTGGGCAGGTCATTGAAGGAATACCTAAGATCATTTCAGATAGTGAGAAGTGCTCTGTAAAAAACAACACAGAGGCTGGGCGCGGTGGCTCATGCCTTTAATCCCAGCAGTTCAGGAGGCCAAGGCAGGTGGATCGCTTGAGCCCAGGACCTTGAGACCAGCCTGGGCAACATGGCAAGACCTCATCTCTACAAAAAATAGAAATTCGCCAAGCGTGGTGGTATGTACCTGTAGTCCCAGCACCTCAGGAGGCTGAGGTGGAAGATCGCTTGAGCTCAGAGTCAAGGCTCCAGCGAGCTGTGATTGTGCCACTGTACTGTAGCCAGAGTGACAGAGTGAGACCCTGTCTCAGAACCCGCCCCCCCCCTAAAAAAACAGGATGATTTGTGATGAAGAGAGAGTAAGAGGACTGCAGATGGAATGTCAGGGAAGGCCTCATTAAAGAGCTAATGTGTAAGATGAGAACTGCAGGCTACCAAGGAGCCGTCTGGCCAAGCCCTGGGGCACAGACTCTAGTCAGAGAGAACGTGCCTGGCTGGAGGCCAGCACCTGGACGTGTGTGCCAGCCCCTGGTGCCACTCTGTGCCCTTTGTCCTACTGTGTGTGGGGGAGACTGGCCTCTGGGGACTGCCTCACCTATCCTTCCTCTAGCTCCCAATTTGTTCAGCCAGTAGGAGGCAGCAGCATATGCAGGGCAGGAGGAAAGCGAGGCTGGGGTATTTCTCCCCCATTCCTCCTGGGCCATGTTTTGGCGATGGCTTTGTTCCTGCAAGCAAGACTACATCTTGGGCTAGATGGCCTCTTGCCGCTGCAGGTTCCAATCATGCTGTTCCCCCTGCCGCTGCGGGTTCCAATCGTGCTGTTCTCCCCACCTTAATGTGGCTGGGGTAAGGGAAGGGGACCCGCATGGGGTGGGCTAGCAAGGCCATGGAAGGGGCTGGCCGTGCAGAGCTTCTGCACAGAGTGAGAAGTCTGGAGAGCTTTCAGCAGGGCATCCCCAGACTCACATACACCTTTTTGGAATGGAATTGAAGCTGCTTACTTTTTTACACCCCAAAACTTTTTATAGATTCAGTTTAGCATCTGAGAAACACTGTTTGCTATAAACTCTGTGACTGTCTCTCAGGTTTTGCCTCTCCCAAGAGAGCGTCCTCCATTTGGCTGTTACCGTTGTTGAGCATCCCAAAGAGTGAGGCTCTATTTAAAGTCACTGCCTCGAGTGGTGGCAGGGATCATCCGGGGGCTCACCCAGCGTAGGTGGCTTCTACCGTTCCATCTGCTACGATACCCGCGATCCTGCTTTTGTGGTTGGAACAGGGCTTCCTTTTTTTTTAACTCCCACCACCCACAGAAAAATAAGAGTGTAATTTTGGAAACAGGCCATTAAGCTGACAGGTAACTTTGCCTTCTCCTTTTTGGGATCCAAAAAGGGATTCTCAAAGCTCGTTTGCCCAGACAGGAGCGTGTTGATTCGTGGGAATCACGTTTTGTCATTTTCCTCTGTATTGTTTAACCAGGCTTGTGAGTGGGTCTTGCCTTTGTTCAGTAACTGACAACGTTAATTTCTCTACAGCTGCTGCGGGAGGATCTGGGCTTCTGTGTTGATTTTCTTTTTCCCTCCCTGCTTCATCTTTGGGATTATTTATCCTTTTTTCGGTTCTCTGCTAGGATCATCCTGAACATGGGGTCCTGTTTCTTGTTCGAGAGCTTCTCAACGTGATCCAGGACTACACCTGGGAGGACAACAGCGATGAGAAAATCCGCATCTACACCTGCGTCCTGCATCTCCTCTCCGCCATGAGCCAGGAGACGTACCTTTACCACATAGACAAAGGTAGCAGAGCCTCCCCCACCAAACCATGCTCCGCATGGATTTCATGAAAGGCAGACAGAATGCTTTCATTTTCTCTTTTATTTTTTCCTCCCTTGTATTTTAGCTTCCATGAACTTCTAGTCCAGGGTCTCACTGTATTTACCTGATCTAAGATTTACCTGGAGCAACTCTTAAGAGTACAGATTCTTGGGCCGGGTGCAGTGGCCCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAAGAGTTCCAGACCAGCCTGGCCAACAGAGCCAAACCCTGTCTCTACTAAAAAAACAAAAATTAGCCAGGCCTGATGGTGCACCCCTGTAATCCCAACTACTCGGGAGACTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTACAGTAAGCCAAGATGGCACCACTGTACTCCAGCCTGGGCAACAAGAGTGAAAACACCATCCCAAAAAGGAAAAAAAAGAGTACAGATTCTTCAGCCCCATCCTGCCCTTGATTGATTGATTGATTGATTGATTGATTGATTGAGACAAGGTCTCACTCTGTCCCCCAGGCTGGAGTGCAGTGATGTGATCTCGGCCCACTGCAGCCTTTACAGCCCAGGCTGAAGCAGTCCTCCCACCTCAGCTTCCCAAGTAGCTGGGAATACAGGCATGTGCCACTGCTCCTGGATAATTTTTTAAATTTTTTTTTGAAGACGGGGTTTCACCATGTTACGCTGGTCTCAAACGCCTGGGCTCAAGTAATCTACCCGTCTCAGCCTCCCAAAGTGTTGGGATTATAACCATGAGCCACCACACCTGGCCTTCCCTTCTTAATTTGCATCTTTAACAAGCACCTGAGATCATGTTGAACATCAGACCAGTCTGGAGAAACACTGTTTAAAAAAATAATTATAATAATTTCAACTTCTATTTTAGATTTAGGAGGTATACGTGCAGGTTTGTGACAGGGGTATATTGTGCAATGCTGAGGTTTGGGGTGCAAATGAGATAGTACCCAATAGGTAGTTTTTCAGCCCTTGTCCCCTCCCCTTCCTCCCCACTCTAGTGGTCTCCAATGTCTGTTGTTTCCATCTTTATGCCCATGGGTACCCAATGCTTGGGGCCCACTTACAAGTGAGAACATGGCGGTAGTTAGTTTTCTGTTTCTGCACTAGTTCACTTAGGATAATGGCCTCCAGTTGCACCCATGTTGCCACAAAGGCCATGATTTCATTCTTTTTTAGGGCTGCATAGTATTCCATTGTGTGTATGTACCACATTTTCTTTATCCAATCCACTGTTGATGAGCATCTAAGTTGATGCTATGTTTTTGCTATTGCGAATAGTGCTGCAGTGAACATACGTGTGCATGTGTCCTTTCAGTAGAACGATTTATTTTCCTTTGGGTATATACCCAGTAATGGGATTGCTGGGTCAAATGGTAGTTCTGTTTTCAATTCTTTGAGAAATCTCCAAAACTGCTTTCCACAGTGGCTGAACTAATTTGCATTTCCACTGACAGAGTGTTAAGTGTTCTCTTTTCAGAGGAACCCTCTTTTGGATCAGTGTGCTACACAATAAACTGGAACAATGGCTAAATATACACATGCATGAGCTTCGTGCCAGGCCTGTTCCTTACCACAGTCTCAGGAAGGACCCTGGTGTGGGTGTTTGCAACTGCTCCTCAGATGATGCCAAGGCTCAGCAGCCCTTGTCTGGGTGCTCTGGAGGAAGGAGGTGGCCTTGATCACCTGCTACCAGACATTTTGAACTTGCTAGTACAAGTTGGGAGCAGCCTCCTCGTGTCCTGGACTTACCACAGGACATCCCAGTTCCAGGCCTTTTCCCACTGAGCCCAAGTATCCTCCTGCCTGGCGGACCCTCAGTTCTAATTTTTGGATTCCAAAAATTGGTCTTAATGTCAAAAGTGCTTTGGCCAGTAATTGTATACTTTACAGTTAAAAAACCAACTCTACACTTGCAAGTTGCAGTGAACAC
TACAATCCATTCAACATTATTCACCCAATGCATGTCAGTGCCCAGCACTGTCCCAGGAGCCAGAGACAGGGCGGGATTGAATGTCATCAGGGACACCATCCACATTGAGTTCCTGGAGGCGCCATTAACAGAATACAGTGTGCAGCCAGCAGACCTGGCGGTGTATTGGCAAATGCAATAGATGAAGTGCCTGTCCTCCTGGAGGTTATAGGCTAGCATGAAACAGAGAGAACCAGGAAAACCACGAGATATTGTTGGGCAGGTCATTGAAGGAATACCTAAGATCATTTCAGATAGTGAGAAGTGCTCTGTAAAAAACAACACAGAGGCTGGGCGCGGTGGCTCATGCCTTTAATCCCAGCAGTTCAGGAGGCCAAGGCAGGTGGATCGCTTGAGCCCAGGACCTTGAGACCAGCCTGGGCAACATGGCAAGACCTCATCTCTACAAAAAATAGAAATTCGCCAAGCGTGGTGGTATGTACCTGTAGTCCCAGCACCTCAGGAGGCTGAGGTGGAAGATCGCTTGAGCTCAGAGTCAAGGCTCCAGCGAGCTGTGATTGTGCCACTGTACTGTAGCCAGAGTGACAGAGTGAGACCCTGTCTCAGAACCCGCCCCCCCCCTAAAAAAACAGGATGATTTGTGATGAAGAGAGAGTAAGAGGACTGCAGATGGAATGTCAGGGAAGGCCTCATTAAAGAGCTAATGTGTAAGATGAGAACTGCAGGCTACCAAGGAGCCGTCTGGCCAAGCCCTGGGGCACAGACTCTAGTCAGAGAGAACGTGCCTGGCTGGAGGCCAGCACCTGGACGTGTGTGCCAGCCCCTGGTGCCACTCTGTGCCCTTTGTCCTACTGTGTGTGGGGGAGACTGGCCTCTGGGGACTGCCTCACCTATCCTTCCTCTAGCTCCCAATTTGTTCAGCCAGTAGGAGGCAGCAGCATATGCAGGGCAGGAGGAAAGCGAGGCTGGGGTATTTCTCCCCCATTCCTCCTGGGCCATGTTTTGGCGATGGCTTTGTTCCTGCAAGCAAGACTACATCTTGGGCTAGATGGCCTCTTGCCGCTGCAGGTTCCAATCATGCTGTTCCCCCTGCCGCTGCGGGTTCCAATCGTGCTGTTCTCCCCACCTTAATGTGGCTGGGGTAAGGGAAGGGGACCCGCATGGGGTGGGCTAGCAAGGCCATGGAAGGGGCTGGCCGTGCAGAGCTTCTGCACAGAGTGAGAAGTCTGGAGAGCTTTCAGCAGGGCATCCCCAGACTCACATACACCTTTTTGGAATGGAATTGAAGCTGCTTACTTTTTTACACCCCAAAACTTTTTATAGATTCAGTTTAGCATCTGAGAAACACTGTTTGCTATAAACTCTGTGACTGTCTCTCAGGTTTTGCCTCTCCCAAGAGAGCGTCCTCCATTTGGCTGTTACCGTTGTTGAGCATCCCAAAGAGTGAGGCTCTATTTAAAGTCACTGCCTCGAGTGGTGGCAGGGATCATCCGGGGGCTCACCCAGCGTAGGTGGCTTCTACCGTTCCATCTGCTACGATACCCGCGATCCTGCTTTTGTGGTTGGAACAGGGCTTCCTTTTTTTTTAACTCCCACCACCCACAGAAAAATAAGAGTGTAATTTTGGAAACAGGCCATTAAGCTGACAGGTAACTTTGCCTTCTCCTTTTTGGGATCCAAAAAGGGATTCTCAAAGCTCGTTTGCCCAGACAGGAGCGTGTTGATTCGTGGGAATCACGTTTTGTCATTTTCCTCTGTATTGTTTAACCAGGCTTGTGAGTGGGTCTTGCCTTTGTTCAGTAACTGACAACGTTAATTTCTCTACAGCTGCTGCGGGAGGATCTGGGCTTCTGTGTTGATTTTCTTTTTCCCTCCCTGCTTCATCTTTGGGATTATTTATCCTTTTTTCGGTTCTCTGCTAGGATCATCCTGAACATGGGGTCCTGTTTCTTGTTCGAGAGCTTCTCAACGTGATCCAGGACTACACCTGGGAGGACAACAGCGATGAGAAAATCCGCATCTACACCTGCGTCCTGCATCTCCTCTCCACCATGAGCCAGGAGACGTACCTTTACCACATAGACAAAGGTAGCAGAGCCTCCCCCACCAAACCATGCTCCGCATGGATTTCATGAAAGGCAGACAGAATGCTTTCATTTTCTCTTTTATTTTTTCCTCCCTTGTATTTTAGCTTCCATGAACTTCTAGTCCAGGGTCTCACTGTATTTACCTGATCTAAGATTTACCTGGAGCAACTCTTAAGAGTACAGATTCTTGGGCCGGGTGCAGTGGCCCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAAGAGTTCCAGACCAGCCTGGCCAACAGAGCCAAACCCTGTCTCTACTAAAAAAACAAAAATTAGCCAGGCCTGATGGTGCACCCCTGTAATCCCAACTACTCGGGAGACTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTACAGTAAGCCAAGATGGCACCACTGTACTCCAGCCTGGGCAACAAGAGTGAAAACACCATCCCAAAAAGGAAAAAAAAGAGTACAGATTCTTCAGCCCCATCCTGCCCTTGATTGATTGATTGATTGATTGATTGATTGATTGAGACAAGGTCTCACTCTGTCCCCCAGGCTGGAGTGCAGTGATGTGATCTCGGCCCACTGCAGCCTTTACAGCCCAGGCTGAAGCAGTCCTCCCACCTCAGCTTCCCAAGTAGCTGGGAATACAGGCATGTGCCACTGCTCCTGGATAATTTTTTAAATTTTTTTTTGAAGACGGGGTTTCACCATGTTACGCTGGTCTCAAACGCCTGGGCTCAAGTAATCTACCCGTCTCAGCCTCCCAAAGTGTTGGGATTATAACCATGAGCCACCACACCTGGCCTTCCCTTCTTAATTTGCATCTTTAACAAGCACCTGAGATCATGTTGAACATCAGACCAGTCTGGAGAAACACTGTTTAAAAAAATAATTATAATAATTTCAACTTCTATTTTAGATTTAGGAGGTATACGTGCAGGTTTGTGACAGGGGTATATTGTGCAATGCTGAGGTTTGGGGTGCAAATGAGATAGTACCCAATAGGTAGTTTTTCAGCCCTTGTCCCCTCCCCTTCCTCCCCACTCTAGTGGTCTCCAATGTCTGTTGTTTCCATCTTTATGCCCATGGGTACCCAATGCTTGGGGCCCACTTACAAGTGAGAACATGGCGGTAGTTAGTTTTCTGTTTCTGCACTAGTTCACTTAGGATAATGGCCTCCAGTTGCACCCATGTTGCCACAAAGGCCATGATTTCATTCTTTTTTAGGGCTGCATAGTATTCCATTGTGTGTATGTACCACATTTTCTTTATCCAATCCACTGTTGATGAGCATCTAAGTTGATGCTATGTTTTTGCTATTGCGAATAGTGCTGCAGTGAACATACGTGTGCATGTGTCCTTTCAGTAGAACGATTTATTTTCCTTTGGGTATATACCCAGTAATGGGATTGCTGGGTCAAATGGTAGTTCTGTTTTCAATTCTTTGAGAAATCTCCAAAACTGCTTTCCACAGTGGCTGAACTAATTTGCATTTCCACTGACAGAGTGTTAAGTGTTCTCTTTTCAGAGGAACCCTCTTTTGGATCAGTGTGCTACACAATAAACTGGAACAATGGCTAAATATACACATGCATGAGCTTCGTGCCAGGCCTGTTCCTTACCACAGTCTCAGGAAGGACCCTGGTGTGGGTGTTTGCAACTGCTCCTCAGATGATGCCAAGGCTCAGCAGCCCTTGTCTGGGTGCTCTGGAGGAAGGAGGTGGCCTTGATCACCTGCTACCAGACATTTTGAACTTGCTAGTACAAGTTGGGAGCAGCCTCCTCGTGTCCTGGACTTACCACAGGACATCCCAGTTCCAGGCCTTTTCCCACTGAGCCCAAGTATCCTCCTGCCTGGCGGACCCTCAGTTCTAATTTTTGGATTCCAAAAATTGGTCTTAATGTCAAAAGTGCTTTGGCCAGTAATTGTATACTTTACAGTTAAAAAACCAACTCTACACTTGCAAGTTGCAGTGAACAC
Task1_train_22440
A variant affecting Chromosome 16, within the gene UMOD (uromodulin), has been observed. Determine if it's benign or associated with disease.
Pathogenic; not provided
GCCCGAGCACCGGCTGTCACTCAGGTACATGAAGACCTTGTCGAAGCCCAGACTCTTCAGCTGGCACTTGCCCAGCGACACCTTCATGTCATTGGCCCCACATTCCAGCCTGTGCTCCAGGAGGGAGATATCTGAAACAGGTTAGGTGGGATTGAGGACGTGTGTCTATAGCTTGGGGGCCCAGCACATCCCCAGGGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGT
GCCCGAGCACCGGCTGTCACTCAGGTACATGAAGACCTTGTCGAAGCCCAGACTCTTCAGCTGGCACTTGCCCAGCGACACCTTCATGTCATTGGCCCCACATTCCAGCCTGTGCTCCAGGAGGGAGATATCTGAAACAGGTTAGGTGGGATTGAGGACGTGTGTCTATAGCTTGGGGGCCCAGCACATCCCCAGGGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGTAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGT
Task1_train_22441
A genomic change on Chromosome 16 affects UMOD (uromodulin). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
CCCGAGCACCGGCTGTCACTCAGGTACATGAAGACCTTGTCGAAGCCCAGACTCTTCAGCTGGCACTTGCCCAGCGACACCTTCATGTCATTGGCCCCACATTCCAGCCTGTGCTCCAGGAGGGAGATATCTGAAACAGGTTAGGTGGGATTGAGGACGTGTGTCTATAGCTTGGGGGCCCAGCACATCCCCAGGGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTT
CCCGAGCACCGGCTGTCACTCAGGTACATGAAGACCTTGTCGAAGCCCAGACTCTTCAGCTGGCACTTGCCCAGCGACACCTTCATGTCATTGGCCCCACATTCCAGCCTGTGCTCCAGGAGGGAGATATCTGAAACAGGTTAGGTGGGATTGAGGACGTGTGTCTATAGCTTGGGGGCCCAGCACATCCCCAGGGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCGGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTT
Task1_train_22442
This alteration in UMOD (uromodulin) on Chromosome 16 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
CCCAGACTCTTCAGCTGGCACTTGCCCAGCGACACCTTCATGTCATTGGCCCCACATTCCAGCCTGTGCTCCAGGAGGGAGATATCTGAAACAGGTTAGGTGGGATTGAGGACGTGTGTCTATAGCTTGGGGGCCCAGCACATCCCCAGGGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGC
CCCAGACTCTTCAGCTGGCACTTGCCCAGCGACACCTTCATGTCATTGGCCCCACATTCCAGCCTGTGCTCCAGGAGGGAGATATCTGAAACAGGTTAGGTGGGATTGAGGACGTGTGTCTATAGCTTGGGGGCCCAGCACATCCCCAGGGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCCCTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGC
Task1_train_22443
This variant affects the gene UMOD (uromodulin) found on Chromosome 16. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
CTTCAGCTGGCACTTGCCCAGCGACACCTTCATGTCATTGGCCCCACATTCCAGCCTGTGCTCCAGGAGGGAGATATCTGAAACAGGTTAGGTGGGATTGAGGACGTGTGTCTATAGCTTGGGGGCCCAGCACATCCCCAGGGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCT
CTTCAGCTGGCACTTGCCCAGCGACACCTTCATGTCATTGGCCCCACATTCCAGCCTGTGCTCCAGGAGGGAGATATCTGAAACAGGTTAGGTGGGATTGAGGACGTGTGTCTATAGCTTGGGGGCCCAGCACATCCCCAGGGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCATACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCT
Task1_train_22444
The gene UMOD (uromodulin) is located on Chromosome 16, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
GGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTG
GGGCCAGGTCCAGCTGGCTGGGCTGACCACCATCTGGAAGTGCTCAGCATAGCCTTGAGCTGATCTGTCCCCTCCCAATGTGATGGGGACTCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACTCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTG
Task1_train_22445
A genomic change on Chromosome 16 affects UMOD (uromodulin). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
TCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTT
TCAAGATTGGACCTCTGACATCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGTAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTT
Task1_train_22446
This alteration in UMOD (uromodulin) on Chromosome 16 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; not provided
TCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATA
TCAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCCCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATA
Task1_train_22447
This variant affects gene UMOD (uromodulin) located on Chromosome 16. Evaluate its biological effect and specify any disease association.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
CAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATAC
CAATGGATACATCCACTGACCAACCACTCAGTCTTGGGTTCCCCTAAATGTGGGTTATATACCAAATGCAGGACGGTTTTGGGGGGTTTTGATGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGGAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATAC
Task1_train_22448
A variant was discovered in gene UMOD (uromodulin), Chromosome 16. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
TGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCA
TGTCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACCCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCA
Task1_train_22449
This is a variant in UMOD (uromodulin), located on Chromosome 16. Is this mutation a likely cause of disease or not?
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
TCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACC
TCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCCGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACC
Task1_train_22450
A genomic change on Chromosome 16 affects UMOD (uromodulin). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
TCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACC
TCCCAGCATTAAATAACAATGAATACTCGTTTAAAAAAATAAAAAGGCTAGATGCGGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCAAGGCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCGGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACC
Task1_train_22451
A variant was discovered in gene UMOD (uromodulin), Chromosome 16. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
GCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGG
GCAGACAGATTACTTGAGGTCCAGAGGTCAATTTCCTTGTCTATAAAATGAGAATACGCATCTCCCACAGTAGTAATAGTAGCCAAAGGAGATGATGCAAGTTACATATGTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCACCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGG
Task1_train_22452
This variant affects gene UMOD (uromodulin) located on Chromosome 16. Evaluate its biological effect and specify any disease association.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
GTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTG
GTATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCCCAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTG
Task1_train_22453
A mutation on Chromosome 16 affecting UMOD (uromodulin) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; not provided
TATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGC
TATACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAGAACGTGAAGTATAATAAAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCATAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGC
Task1_train_22454
The variant affects gene UMOD (uromodulin), which is on Chromosome 16. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
AAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATA
AAAAAAAGAAAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACACTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATA
Task1_train_22455
Given a variant located on Chromosome 16 and affecting UMOD (uromodulin), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
AAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGG
AAGAAAGAAAGAAAGAAAGAAAAAGCAAGCAAGCTGCAATTACTTTCTACCCTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCCGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGG
Task1_train_22456
Consider a variant on Chromosome 16 in gene UMOD (uromodulin). Determine its clinical classification and disease relevance.
Pathogenic; UMOD-related disorder
CTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGG
CTTTTCACATCAAGGAGACAGTCCCAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACAGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGG
Task1_train_22457
This mutation is located in gene UMOD (uromodulin) on Chromosome 16. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
CAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCA
CAGCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGAGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCA
Task1_train_22458
This alteration occurs within gene UMOD (uromodulin) located on Chromosome 16. Is it associated with a disease or is it a benign variant?
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
GCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACA
GCTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGGAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACA
Task1_train_22459
This variant affects the gene UMOD (uromodulin) found on Chromosome 16. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
CTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACAT
CTTGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCCGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACAT
Task1_train_22460
Given a variant located on Chromosome 16 and affecting UMOD (uromodulin), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
TGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACATTT
TGCCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGGCGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACATTT
Task1_train_22461
This gene mutation involves UMOD (uromodulin) on Chromosome 16. Is it associated with any clinical condition, or is it benign?
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
CCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACATTTTG
CCACTAATGTCTTTAATGCCATGTACTCACTAACTTCCCTCTCTCTCTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACCCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACATTTTG
Task1_train_22462
Given a variant located on Chromosome 16 and affecting UMOD (uromodulin), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Familial juvenile hyperuricemic nephropathy type 1
CTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACATTTTGAAGAACTCAGTCATTTGGAGCAGGAAGTAGCCAGATGGAATAGTGT
CTCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGTAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACATTTTGAAGAACTCAGTCATTTGGAGCAGGAAGTAGCCAGATGGAATAGTGT
Task1_train_22463
Gene UMOD (uromodulin) on Chromosome 16 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; not provided
TCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCAGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACATTTTGAAGAACTCAGTCATTTGGAGCAGGAAGTAGCCAGATGGAATAGTGTT
TCTTTTTTTTGAGACGGAGTTTCTCTCTTCGGCGACAAGCCCAGGCTGGAATGCAGAGGTGCCATCTTGGCTCACTGCAACCTCCGCATCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCACCTGCCACCAGACTCACCTAGTTTTTGTATTTTTAGTAGAGATGGGATTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCTGCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCACTAACTTCCCTCTCAAACAGAGAGCAGGCCTCGGGCTGAGAGTTTGGGGCAGGAAACAACATCCAGCCAGAATTCTTGTTTAATTTTTTAAAAATTGAAGTATTTTTCTAATTTTTAGTATTTATTTTTTAAAATTTGTTTTATGGAAGTATTACACAACTGCTGAAATTTAGTAACCTTCTTTTCTTTTTAGTAACTTTTATTTTTACAGTTAACTTTCTGTCTAAGGTAAGCATAACTTGCCACAGACAGATGAAGTCCTGACCATCAACATTCCAAATTTGCTTAAGAGATTCAGTCCATTAGAAGAAAAACAACTTAATAAAAGTCATGGCACAGGTAACACTTGGATAAAGCAAGTGAACCAGGGTGCCAATTGTAAAGTTGGCACTTGGATGTAACTAAAATCATGACTGAAGTCTGAAAATACTATTTTCATCTTCAATAATTGTACCTATGAGAAATCTGAGGCTTGTGCCTGGCCCGGAGTACTGAGCTGATTGGTGGACTGGTCATCAGGCCTGAGCTGATTGGTGGACTGCTCACCGGGCCGGGCTTGTGTTCTGGTGCTGCAGGAATAGGGCTCAGATGGTCTTTGGCTCCCAGATGGCAGCAACGTGGGTGCCCACTGTGGTGTGGGCCTCAGAAAGAAGGCTGGGTGCGAGGAGGTCCCCAAATCTTTGGCAGCTTTGAAGTCAACTAAAGGGAGACTCAGGGAGCCTCAGAGAGCCTCTTGCCGGCTTTAATGGGTATTAGTGGATCTTCTGTTTTCACTCAGGTTGGATATATATCCCCTGCGTCATACCCATATGGCCCCAATCTCACAGGGGAGGAATGTGTCCCTCCCCCAGGCAGTGACAGGTTTCTCAACAACCCGCTTCCTCCCCACTGGCCTCACCAGTGATGTTGAAGTCCTGTTTGCACTGGCAGTGCCATCTGCCATTATTCGATTTGCAGTCCTCGTCTATACTGCACTCCTCACACGTCCCCTCCACGGAGCTGGGGTCTGCAGGGTCACAGGGACAGACAGACAATCAATAAGGACGCACCCCCGTCCTCTGCAGTGCCTTTCCAGGCCTGGGATGAGGACTGTGGGGAGACTCCGGCTGACCTGTGCAGTACGCCAGGTGACACTCGGGGGGCGCTGTCAGGTTGTAGACGTAGTAGCCGCCGGCACAGGCCTTCACCTGGACGGACGCATCCCACAGGCAGCAGTGGCCGCTCCAGTGCGCGCAGGCCTTGCGGCTCACGATGCCCTCGTCGCTGGACGGATGCGTGCCATTGAGCCACATGGGGGCGGCCGTGTTGCAGCGCAGGACTGGCACGCAGGTCTCGGCCATGCGCGCACCGCCCTGGCCCACGAAGCGGTACCAGCCGCGCAGGTCCGTGTCGCAGGCGTAGCCCTCCCCGTACTCGGTGCTGCGCCAGTACTCGTCCAGGGTGCGGTGCGCCTGGCACGGATCCGCGCACACGAGCGCGTCGCCCTCGGGCACGCAGTCCAACCCCGGCCCGCAGGAGCCCGGGGAGCACTCACAGTGCCATCCATCCCCCCGGTAGCCCGCGGGGCATACGCACAAGTAGCTGCCCACCACATTGACACATGTGGCCAGGGCGTGGCAGTGGCTAAGCCCAGGCTCAGCGCACTCATCCACGTCTGTGCAGCCGAGACCGGGCGACAGGCGGAAGCCTTCGGGGCAGACGCAGGAGAAGGAGCCTGGCGTGTTTACGCAGCTGCTGTTGGCGGAGCGGTTGTGAGCTCCAGGAATGGCGCACTCATCCAGGTCCACGCAGGTCAGGCCATCGCCGGTGAAGCCCTCCTGACAGGTGCACGTCGTAACGGCCTCATCCTCCGTGCAGGTGGCATTGCTGTGACATTCAGAGCACCATCCTGTGGACAGAAAAGCCCAGCTTCAGGGTTTGGGCAGCTGGGCCCATGGCCACCCAGAGATCCTTCCCTCATTCTCCAGGGAACTCATTATTTTTAAGACTTATTCCCTAGAGGGCTCCCTCCAAAACAAGGAAAGAAGCAAAGAAACAAAACTCCTCTGATGATGTCAAGCCTCCACCGTTCATTCTGTGTTTATTTCATTGTATTTTTTAACTTTATTTATTTTTTTGGAGAGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTAGTGCGATCATAGCTCACCATAGCCTCCAATTCCTGGGTTCAAGCGTTCTACTCCCTGAGTTCAAGCCACCACCGCACCCTGCCTCAGCTTCCCAAAAAGTTGGGACCACAGGCACGTGCAATCGCGCCCAGCTCCACCATTCATTTTTTGTGTTAAGCATTGCTTTCAAGCTGTCTTCTTTTAAAATAGCCACATTCAGAAAAGTAATGCGCAGAATTCCTATACTTTGGTAGGATTTACGGTGAACCTGTTGCCCCTCCCTTTCTTTGCACATTTTATGTTTTCTGCTTCCCTGGCTGGTGAAATCTTCATCAGGACCCTGCTCAGTGTCGCCTCCTCTCTGCGGAGTCCTCCAACTCCACCTGGCTGGGCAGTTGTACTTTGTTCCTCCGTAATAAAAATAACCATTAAAAAAAAAAAGAAGCTGTTGTTTATTAAGCAATTACTATATGCCAGGCAATAGGATGTGCACTTTTCACTCACTATCTTGTTGAATACTTCCCAAGGGCCTCGTGAGGTCAGTTTTTTATGTATCCTTATTTTAAAGATGAGGAGACTGAGGTTCAGAGGGATTAAGCCCCTTACTCCTTTGGTAAGAAGTAGAACCAGGATAAAAACGCAGATGGCAGGACCACAAAATATGTGCTTTTAACCAGGACACCGCAATAGTATTCATCGTGCCCCAACGTACTCCAGGGAGAAAATGAAAGTGGGGTGACAGCAAATCTCAACCCAATGGAATGACCTCTTAAAGTTGAAAGGGAAGGTGTTTGGATCCTCCTGCATGGGTTCAAATCTCCTATGTGATAGAGTATGTTTCTGACTTCCAATAAAGGGCCTGCAGGCCTTAGAGATGTTCTAGCCCCTTGCTTTTCAATGTGTACTCCAGGGACCCCAGTATGAGCATCGCCTGGAAGCTTGTTAAAAATTCAGCATCTCAGGTCCTACTGCAGATCTGCTGAACCAGAATATGCACTTTAGCAAAATTTCTAAGTCAGTCCTGTGCATATTGAGTCTAAGAAATGGACTTAGAATGAAGACAATGCAAGTCTCAAGTGCGATAGGAGGATTGAGATCACCTCTGACAGGTGCTACATTGCTTCCCCCACACATTCACACATACACGTGCATACACACATATACAACGCACACACACTTTTCACTTACTTGCTTCTGAGGTGTCAGTGGCTGCAGTTGTGATGAACCAAGAGGCCACCACCACCATCAGCATCCAAGTCAGAGATGGCTGCCCCATCCTTTCTGCTCTTCCCGCTACTTCAGGTCTAGATAGCACCTGCCCAAAGGAAAGACGGGTTGGCCCTTTGAATTTTTCTCTCTGTCTCTGATGTCTGGTGTCCTGTGAACAGAGATGGATGGGACAAATGCATGATCTAACTCTCCTCCCCACAGCTGGAAGGAGTGCTTTGATTGTATAGTATACAACTCCAGGAGGTGTCACTTATATGGACTAAAAAATTGCATAACACTGCAGCCCTTGTTTTGCTGGGACTTTACCCCTTGTACTCCCCCTCCTTACCTCACCAACATCCCAGTCTTGGCTCCCCAATTCTCAGCACATTGCACATTTTGAAGAACTCAGTCATTTGGAGCAGGAAGTAGCCAGATGGAATAGTGTT
Task1_train_22464
This variant affects gene ACSM3, THUMPD1 (acyl-CoA synthetase medium chain family member 3| THUMP domain 1 NAT10 acetyltransferase adaptor) located on Chromosome 16. Evaluate its biological effect and specify any disease association.
Pathogenic; Neurodevelopmental disorder
TATCATCAGTAAATCAACTTATTGAGAATAAAGTCTCTTCAACTTTGTACTGCATCTTGCCCCAGCATTTTAATGTTATTAGATTCTCACCAACCATGCATATTTTCCTTTCCTGAGATAAGTTCTGCTACTAAATAATTTGCTTCTTAAACCTTTTGACTAAAGGTGATTTCTGAACAAAAGCCTTACTGTTTTTGATAGTCCAAAAGCCATTTGAAAATAATGAATATCCTTTCTTGTCAAGTGGCTGTGATTTATTGTTACAATTGCTAGTTTTGTAAGTTGCATGTCACAGACAATGCACAATGGGACAGGAGAGCTTGGACTGAGTCCACATAATACCCTTGAGAAGTAGCTTTCTTTATTAAGACAGAATTTCTTTGTGTCCCTTGTTGCACTAGTATACTGAAGTATACTCAGAAGACTGAAGTTCTTCATCACCAACCTTTTCAGAAATGTCTGTAGTTCTATGCCTAAAATGGTTCTCGTCTCTCTCACATCTTGCCTTCCAAAATTGCGACACTGGACTGTCAGCTATATTACACACAAATGTTAAAAAAAAAAAAAAAAAACAGACATAAACAAGAAAATCACAAAAGTACAAAAACTTCACTAAACAATTCACTTCTAACCTACATGATCCACATTTTTGCAATGTTTACAACAAAGTGGCAGGCAGACAGCTGAGCTGTGGCATGTAAAAACTCCTTCCTTAGAATGAAAACTTCCCTCTGATTTTCTACTTCACAGGTAGTTCACTCCCTTAAGTCAGCTGGCACTGCAGAAGAGGAGCCTGGGAGAGGCCAACATCCCCCTCCTATCCTCCCCTCTTTGCAACAGCAGCACATGGGTCTGCCTCTACGTAATACCATAAAGGCTGAAAGATCCCTAAAAAAACTGTTAACAGGGCTGCGCAATCATTGCTCACTACTGTGAGAACAGCATAATGCAGCACACAAATAAAAAACTGTTTTTAGTCACAATTTAAGGTGGAGCCCCAGCAACATCTCGTAGAGCCCCAGGTGAGAAACCCACCTCCAACACCAAATGACTTCCTATGAGAAGTCATTTTCATTTGACTTGGATCCTTCTGTGGCTTGACTTGCAAGTTCAGGTTTGGCTCCTCCCTCATTTACCACCTGTGGATTAGACGTTGGTTTTGTCTGCCCCAGCTCCTCAGTATTCTCTGGTACCTGCTGGTTATTTTTTCCTTCTGCTGTGTTGTTTTGGTCTGATTTGTCCGCAGATTCCAGTTTAGCTTCTTTCCCATTTCCCTGCTTTGAGTTAAGCTGTGACGGATCCTTAGGGCTCTTCACCACCTCCTGGAGATTGTATTTTCTAAACAACATGTAATCTTTCACAACACTCAGGCAACAGACAGCTTTGATGATTTCTACTACCACTGTGTACTGTGGATTGGTGAGATCCACTTTATTTTCTGAATTGAGGGTGCACACTATTCCTGTAACAAAAACAGAAAAACACATAGCTGAGGAGGATACCATTACATCTGATAGATACAAAAAATCTTTTGTCTCTGTTTCTTGTTAAAACAAGACATACAGTAATCCACTCTTCTATGTGGACTTCAAATAATCTGAACCCTTACAATAAATAAACACAAATGAAACCCTACAACATTTAATAAGAATTTTTTTCCAAACAAAATTCAATTTCGAGTTAAAAAAGACTTTTATCTAACTACCAGAAAATCTCATATCCGACATATTGAAATCAGTTGATTTAATACTATTTTAAGAACATTTTAATATATTTGTTCTACACTCAAAAATGTAAGCCTTAAATCTTTAAAAAGAAAAAAATCCTTAAAAAACAAGTATTTACCATTGAATGCCTATGGAAAATCACTAAGAGAAACATACCTGCCAATTCTCTGATAACTTCTTCTCTATTCACATGACTGTTATTTCGAGATTTGTACACAATCTGAAATGTCCCTTTGTTTGGAGCTTTAAACCAGGGTTCCAAAAATGTTTCTGCATATTTTTTCATATCTTCTAAAAAAGCCTTGCATGTGCCTGAGATGGGTAACATTCGCAAAATAACTCGAGTCTTCTTTTTCTTGGTTTTGTACATATCCTGGAGAATATGATGCACCAATTTCTCAGGCTCTTAAGAAAAAAAAAAAGTTAAGAAGATAATTTCTCAGACATCTTAAAGATCGAACTCTAAAATGAATTTTCACTGGCAATGACATAAGTTGACAGAAGAAATTCTCATAATGAATTTTAAATGAATCTACCTAGTCATTCTTTCCAAACAGTATTTCTTCAGTGCCTAATACGTACTATAATGTATCTAATATATTTTAACTTTTCATCATTATTACTGCTTGCACTAGAAATGACTGTTTAGGTAGACACCGTTGTTAACATTTTTGTGATGTCCTGAGTTATCCAACCGTAACACCATGCTGTTGTTTTCCTGTAACAACAGAGTACATTAAACAGTACACACTTTTTTACAAAAAAAAAAAAAAAAAATTCTGTGAGTCACTTTAAAAGATGTAATTAATCCATTAGCTAAGTTAGCACACAAGTCTAAATCTCAGACCCAAGAGGAATCCCAGAACCATGCTGGGCACAACATCATGAAAGGGAGGTCCTCAGGCTGCAACTTGCCTACATACAAGTATATTTGGGGCTGCTCCGAAAATTTGTAAATTAGTTGACCACACTGAAAAACAAAAAAACTCCAGATTTCAAACTTCTTTTGAGAAATTCAAATACCTGGCCCTGCATTCCCAAAGAGCAACAACTGGCTGGAGCTGAGTAGCAGCTGCCCCTTATTTACACAGAACTGGCACTCTAGTTCTGCCTTAAGTTATATACGAAGGAAGCAGCAAAGCCAGGTTTCCACTCATAAGCCAATGCTACGTCCACCACCCCATTCTACCTCTCCACAGGCCAACTGCTAATACAGTGTACAGAAGCTGCCATCAAATGATTAACTGAGTCATGCCCAAGAAGCCATTTTGTAAGCAGTATTCCCTGAGACAGGAAGATACCCAGATGTTATGAGATCGATAATCTTAGCAAGTATTTGTCACACCTATCCCAAGTGTCCTGATGAAGACAACGTTATTTGCTCCACTTTCCACTGACTGGAATCTTCTTAACCTCATCTCTGTAGATGCCTTAATGTCACCAACTTCTTTCTTCAAGGCAGCCTCCGCATCATCATCCTCTCCCTCACTTCCAGAGGGCTGCTGATCCTTGTCTGTAAACTGTTTGCATAAAACTAATGAGCAGAAATGACACAACAGCTCACATTTAAACACTATAAGTAATTATTTATGTGAAGTCCCTGGCGGCAGGTGGCTCAGTATTGATTTTTTTTTTTTTTCTAAAGATGGAGTCTCGCTTTGCCTCCCAGGCTGGAGTGCAGTGGTGCGATCTTGACTTGCTGCAACCTCCGCCTCCTGGGTTCAACCAATTTTCCTGCCTCAGCCTCCCAAGTAGCTGTGATTACAGGCGCATGCCACTACACACAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATGTTGGTCAGGCTGGTCTTAAACTCCTCAGGTGATCCACTCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTACCATGCCCAGCTGACTCAGTATTGATAATAAAGCTTTTTTTACGAAGCTGGGACACCACACCCTTCAAAACGTGGAGCAAGGCCGGAAGTGGTGGCTCATGCCCATAATCCCAGCACTCTGGGAGGCAGAGGCAAGCAGATCACCTGAGGTCAGAAGTTCGAGACCAGCCTAGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAATTAGCCCGATGTGGTGGCAGACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGAAGGCAGATATTGCAGTGAGCTGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAAAAATGTGGAGGAAGAGGGAATTCCCGCAGACTATAGAATGTAAAATTTGAAAATGTTTTCAAAAGCATCCTGACAGTT
TATCATCAGTAAATCAACTTATTGAGAATAAAGTCTCTTCAACTTTGTACTGCATCTTGCCCCAGCATTTTAATGTTATTAGATTCTCACCAACCATGCATATTTTCCTTTCCTGAGATAAGTTCTGCTACTAAATAATTTGCTTCTTAAACCTTTTGACTAAAGGTGATTTCTGAACAAAAGCCTTACTGTTTTTGATAGTCCAAAAGCCATTTGAAAATAATGAATATCCTTTCTTGTCAAGTGGCTGTGATTTATTGTTACAATTGCTAGTTTTGTAAGTTGCATGTCACAGACAATGCACAATGGGACAGGAGAGCTTGGACTGAGTCCACATAATACCCTTGAGAAGTAGCTTTCTTTATTAAGACAGAATTTCTTTGTGTCCCTTGTTGCACTAGTATACTGAAGTATACTCAGAAGACTGAAGTTCTTCATCACCAACCTTTTCAGAAATGTCTGTAGTTCTATGCCTAAAATGGTTCTCGTCTCTCTCACATCTTGCCTTCCAAAATTGCGACACTGGACTGTCAGCTATATTACACACAAATGTTAAAAAAAAAAAAAAAAAACAGACATAAACAAGAAAATCACAAAAGTACAAAAACTTCACTAAACAATTCACTTCTAACCTACATGATCCACATTTTTGCAATGTTTACAACAAAGTGGCAGGCAGACAGCTGAGCTGTGGCATGTAAAAACTCCTTCCTTAGAATGAAAACTTCCCTCTGATTTTCTACTTCACAGGTAGTTCACTCCCTTAAGTCAGCTGGCACTGCAGAAGAGGAGCCTGGGAGAGGCCAACATCCCCCTCCTATCCTCCCCTCTTTGCAACAGCAGCACATGGGTCTGCCTCTACGTAATACCATAAAGGCTGAAAGATCCCTAAAAAAACTGTTAACAGGGCTGCGCAATCATTGCTCACTACTGTGAGAACAGCATAATGCAGCACACAAATAAAAAACTGTTTTTAGTCACAATTTAAGGTGGAGCCCCAGCAACATCTCGTAGAGCCCCAGGTGAGAAACCCACCTCCAACACCAAATGACTTCCTATGAGAAGTCATTTTCATTTGACTTGGATCCTTCTGTGGCTTGACTTGCAAGTTCAGGTTTGGCTCCTCCCTCATTTACCACCTGTGGATTAGACGTTGGTTTTGTCTGCCCCAGCTCCTCAGTATTCTCTGGTACCTGCTGGTTATTTTTTCCTTCTGCTGTGTTGTTTTGGTCTGATTTGTCCGCAGATTCCAGTTTAGCTTCTTTCCCATTTCCCTGCTTTGAGTTAAGCTGTGACGGATCCTTAGGGCTCTTCACCACCTCCTGGAGATTGTATTTTCTAAACAACATGTAATCTTTCACAACACTCAGGCAACAGACAGCTTTGATGATTTCTACTACCACTGTGTACTGTGGATTGGTGAGATCCACTTTATTTTCTGAATTGAGGGTGCACACTATTCCTGTAACAAAAACAGAAAAACACATAGCTGAGGAGGATACCATTACATCTGATAGATACAAAAAATCTTTTGTCTCTGTTTCTTGTTAAAACAAGACATACAGTAATCCACTCTTCTATGTGGACTTCAAATAATCTGAACCCTTACAATAAATAAACACAAATGAAACCCTACAACATTTAATAAGAATTTTTTTCCAAACAAAATTCAATTTCGAGTTAAAAAAGACTTTTATCTAACTACCAGAAAATCTCATATCCGACATATTGAAATCAGTTGATTTAATACTATTTTAAGAACATTTTAATATATTTGTTCTACACTCAAAAATGTAAGCCTTAAATCTTTAAAAAGAAAAAAATCCTTAAAAAACAAGTATTTACCATTGAATGCCTATGGAAAATCACTAAGAGAAACATACCTGCCAATTCTCTGATAACTTCTTCTCTATTCACATGACTGTTATTTCGAGATTTGTACACAATCTGAAATGTCCCTTTGTTTGGAGCTTTAAACCAGGGTTCCAAAAATGTTTCTGCATATTTTTTCATATCTTCTAAAAAAGCCTTGCATGTGCCTGAGATGGATAACATTCGCAAAATAACTCGAGTCTTCTTTTTCTTGGTTTTGTACATATCCTGGAGAATATGATGCACCAATTTCTCAGGCTCTTAAGAAAAAAAAAAAGTTAAGAAGATAATTTCTCAGACATCTTAAAGATCGAACTCTAAAATGAATTTTCACTGGCAATGACATAAGTTGACAGAAGAAATTCTCATAATGAATTTTAAATGAATCTACCTAGTCATTCTTTCCAAACAGTATTTCTTCAGTGCCTAATACGTACTATAATGTATCTAATATATTTTAACTTTTCATCATTATTACTGCTTGCACTAGAAATGACTGTTTAGGTAGACACCGTTGTTAACATTTTTGTGATGTCCTGAGTTATCCAACCGTAACACCATGCTGTTGTTTTCCTGTAACAACAGAGTACATTAAACAGTACACACTTTTTTACAAAAAAAAAAAAAAAAAATTCTGTGAGTCACTTTAAAAGATGTAATTAATCCATTAGCTAAGTTAGCACACAAGTCTAAATCTCAGACCCAAGAGGAATCCCAGAACCATGCTGGGCACAACATCATGAAAGGGAGGTCCTCAGGCTGCAACTTGCCTACATACAAGTATATTTGGGGCTGCTCCGAAAATTTGTAAATTAGTTGACCACACTGAAAAACAAAAAAACTCCAGATTTCAAACTTCTTTTGAGAAATTCAAATACCTGGCCCTGCATTCCCAAAGAGCAACAACTGGCTGGAGCTGAGTAGCAGCTGCCCCTTATTTACACAGAACTGGCACTCTAGTTCTGCCTTAAGTTATATACGAAGGAAGCAGCAAAGCCAGGTTTCCACTCATAAGCCAATGCTACGTCCACCACCCCATTCTACCTCTCCACAGGCCAACTGCTAATACAGTGTACAGAAGCTGCCATCAAATGATTAACTGAGTCATGCCCAAGAAGCCATTTTGTAAGCAGTATTCCCTGAGACAGGAAGATACCCAGATGTTATGAGATCGATAATCTTAGCAAGTATTTGTCACACCTATCCCAAGTGTCCTGATGAAGACAACGTTATTTGCTCCACTTTCCACTGACTGGAATCTTCTTAACCTCATCTCTGTAGATGCCTTAATGTCACCAACTTCTTTCTTCAAGGCAGCCTCCGCATCATCATCCTCTCCCTCACTTCCAGAGGGCTGCTGATCCTTGTCTGTAAACTGTTTGCATAAAACTAATGAGCAGAAATGACACAACAGCTCACATTTAAACACTATAAGTAATTATTTATGTGAAGTCCCTGGCGGCAGGTGGCTCAGTATTGATTTTTTTTTTTTTTCTAAAGATGGAGTCTCGCTTTGCCTCCCAGGCTGGAGTGCAGTGGTGCGATCTTGACTTGCTGCAACCTCCGCCTCCTGGGTTCAACCAATTTTCCTGCCTCAGCCTCCCAAGTAGCTGTGATTACAGGCGCATGCCACTACACACAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATGTTGGTCAGGCTGGTCTTAAACTCCTCAGGTGATCCACTCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTACCATGCCCAGCTGACTCAGTATTGATAATAAAGCTTTTTTTACGAAGCTGGGACACCACACCCTTCAAAACGTGGAGCAAGGCCGGAAGTGGTGGCTCATGCCCATAATCCCAGCACTCTGGGAGGCAGAGGCAAGCAGATCACCTGAGGTCAGAAGTTCGAGACCAGCCTAGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAATTAGCCCGATGTGGTGGCAGACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGAAGGCAGATATTGCAGTGAGCTGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAAAAATGTGGAGGAAGAGGGAATTCCCGCAGACTATAGAATGTAAAATTTGAAAATGTTTTCAAAAGCATCCTGACAGTT
Task1_train_22465
A variant was discovered on Chromosome 16, affecting ZP2 (zona pellucida glycoprotein 2). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Oocyte maturation defect 6
AGGAGTCTAAGACCAGCCTGGCCAACATGGTGAAACCCCGTTTCTACTAAAGATATAAAAATTAGCTGGGCATGGTGGCAGGCACCTGTAGTCCCAGCTACTTGGGAGGCTAAGGCAGGTGAATCGCTTGAATCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCATTGCACTCCAGCCTGGGGGACAAGAGTGAGACCTCGTCTCAAAAACAAAACAGAAGGCTTAGTAACTGAGCTACCACAGCTTCAAGAAAGCAAAGGTGCAGTTTTAGCCAAGTACACACTATTCCATAAGAATGGGTGAGATCCAGTTGTAGGACAGGACACGGCAGGAGAGCTGTAAGGTTGAACACCTATGTGTACAAGTGTGTGGCTGCAACCTCAGAGCATCAGTGCTCAGATTCTAGAGTCAGATGGATATTCTAATACAAGCTCCATTGTTTAAGTATTGTTTTGGGCTGGTTATTTAGGCAGCAAGCTGGGGTTTCTTCATGAAAGACGAAGACTAGTACAACTAGTGGATGTGGAATACATAGCACTGTGCCTGGCATATGGTAGGTGTTCAGATGGATAGAGGCTAGAGACCAGTCTTTCCAGATGATCAACACCATAGTAGAGTCAGACTTTCTGGGGCTTTGGAACTCATTCCTTAAGATTCAAGAGGTGATTGGAAGGCAGCATGTGGCCAAGTGTGGTGGTTCACACCTGTAATCCCAGTACTTTGGGAGGCCAAGGTAGGTGGATCACCTGAAGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAGATAGCAAAAATTAGCTGGGCTTGGTGGTGTGCCCCTGTAATCTCAGCTACCCAGGAGGCTGAGGTAGGAGAATTGCTTGAACCCAGGAGGCAGGGGCTACAGTGAGCTAAGATCATGCCGCAGCACCCCAACCTGGGTGACAGAATGAGACCCCATCTCAAAACAAAAAAAAAAAAAACAGAAGGCAGAAGAGTCCCAATTAGAAAACAAGGACTAAATCTGGATCTCACATGACTGAATGCTGCTCTAAAGCCCAAGAGGGTTTATTCCCATTACTGGCAAGTTTTGATGGATTAGCTGGGTAACCTGATAGTACAGGGAGTACCTACCCATCCACGACAACGTTCCACTGGGGGAAAGAGTCTGGATCCATGGTGGACGTCGCCCAGCAGTCATCTAAGACCAGCTTGATGTTGGGGTCATCCCTGTTTAGGACTCTCACTTCCATGTAAATTGGTTGGCGGAGGAATCTCACTAGAGGGTACTCGTTTTCCCCATAAGGTTGTTGGTAGGAATTATCTGAAATTGAATGGTATTCAAGTAGTTAATGGCTGCAACACAGATTCATAGGTCATCACTGCTCCATTAGTCTGGCAGTATCAGGATGTTCATTTTAGGGAGAAGTTTGAGATCATTTAAGCAATTTCACAGACTGCAATCTCTTACCTGGGTAGCTTTGCAGGATCAAGGTAAATGGACCCAACTTCACTGAGGCCACTGGAGGAGTAAGGCTTTCAACGTTGATGTTTAGTAGCATGTCATTCCTGCTATAAGAACACTTCACTGTCATTCTGTAAGAGTTTGGAGGGAAGGTAGGTACAGAAAATTTCAGGTTAAAAAATTGCTTGAGTTTAAACTAGAGCTTAAGAGTCAAATAGCAATTTTATCTCACCTGAACTCACTGTCTCTAGATATTTTGCTTGGAGGAAAATCCGTCCAGAGAGCATGTATTTCGTTTTCATAGACGACTTTATCATCTTCGAACTTAAATGTCAGAGAAAGTGGGTTAGCAGCCAGTTATGTCAAAGATGAGACTTAACCTCGTGCCATCTGCCAGTACTAACCTTATATCTCGTTCCACATCCATTCAGGGGTATGTGGAACCGTACCAGCCCCTGAGACTGAGCCTCAAAGACAGGCTGGCAGGATGAGTTTCCCACCCTCAGAGTACCCAGGTCAAGAGCTGGTTGTGTTTGGTAGCTGTAGACCTCGACGTCCATAAACCCATCCTGGGTGCACAGCTCCCCTGTAACTAGACAGCGGTGAAAGTTTAGAGAAAATAAGTTTGTCTGCCCTGTGATACTGTCATCTCCCAACCTGATATGCTACGAGGGAGAAATTCTAATTTAGCAGGAGGCATCAGAATCTGTCTTGAAGTCTTTATGAGGGAACCTTGATCAGCAGCTTGAATTACAAAGGGAGCTGAAGTTAGTTGATTGTTCTATGTGAGAGTAGGACTTTTCATCCAAAGGAGGGACCAGTAGATGTAGGAAGAAGTGCTATATGGTATAAGACCAGTGAGAATCCTGATGAAGGGCAGGAGTTGACTCAAGGTTAAACTTAATGTGGCTTTAAGTACAGCGCCTATGTTATTGTATCCTTTCTTTGTATACTCACAAATCCTGAGTAGTTTGGGGAGAAACTGAGGCAGGAGCTGGTTTTCCTATTTGATCTGACCTGTGCAGATCACATTAAACAGAAGCACATGGTGGAGGCAATGCTAAACAAGAGATATTCACTCTATTTAAGAATTTGTAGGAATTTTGGGGTGGGGGGGTACTTAAACTTAATTCTAATTAGAAGTTTGAATATTCTTACCTAGATGTCAGGTTCAGGCTCCTAAGCCAAAATATCTAGATTGTTTAACCATGGAGCAGTTGCCATAAAACCTACCTATGTAGGGATCTTAAAAATATCATACTTAGGACCCCATCGTAGCAGCTACACTGTTTCTAATCTGACTAGTCTTTAGTTTCTTCAGTCTATAAGCAATAGATCAGAATCTGACCTTCTATACATTTGCCCACATGTACAAGAGCCAAGGGAGAAAAAAGGTAGAACATGATTTTAATAAAAGGTCTTTACCTATAGAAACGGGTGACTCACAGAGACACTCAGGATAGATCACCATGGATACTGTCTCTGGCCGAAGGAGAAAGGTCAGCTTGAGTGAAGCTAAGTAGAACTGATGGAGTAGGCATTTTTCAGATAACTGAAATGAGAAAATGTCAATTAGCAGCCACAGTCCGTTGGGGCCCGGAACCGTCACAGGGAGGCAGGAAGCAAGTCCACTAAATACTTGCAGGACACACTCCAGACTTATCTGGGCTCCCTTTAAACCAAAACAAGAGAGACCCTATCACTTCCTCAGATCTGGATGTATCCCCAGGCAGATTTATTGCTTTAAACTCATGCCCTGGAGTACCCAGCACTGTACTCTTTGTACGAGGCACTAAAGCTTGAATTAGCAGATCAAATTCCAAAGAATAGTGGAATCCTCTGCCAAGCCAGGTCTGAGTCAAAAGGACTCTACAGATGTTATAAAATGGTATTGCATAATATGTACCCCCAACCTAAGATTATTCTCTGGTATCCCTGGCAGTTCTAGTGAAGACTAACCTCAACAGCAACAGTACGGGACCCTTTTGTTTAGATCAAGGTGTCCTGTTCGTTGACCAGGACAGATTCATCATTAGGTATTTGACAAGTAGTTGCTACTACTCAGTTGGGGCCTTAGACAGTTTTAAGACTTAGAAAGACTTAGACGATTTTTCATGACAGAAGTTAAAGAGGTTTTGTGTTAGAGAATGAACTTTAGTTACTTGATATTTCACTTATACAAGATGATCAAATGAGGCCTTTTGGAGTTTGAATCTGTTATGTTGGCAATTAGAGCTCACGGGCAAGTTATCAGCCGTATGAGGACTACCCACAAGAGTATACTTCAAGTCAGGACCCGGTGGAGTTCAGTGGTTGACAATTGAACATACTTTCGTTTTGAGCAGAGTTTTGCTGAAATGCAATTTCATGCCATTTGTTGCTTCTAGATCAATTCCATTGTCATGCAGCTGGCTCACATCAATGTTCTGGTTTTCAAAGCTCACAGACTTAAGCTTCCCAGGAAACTCTGGTATGGTGAGAGTCATGTGTGTGGCATTGCAGGTCACAGGATCTAGAAGGAATGACAACAGAATGCCCATTACCAGCCTTGATTAAGCTTCTAGGACAATGTCTCCCACACTGAGGTTGCAGCTATCTGGGACCTTACCTGGTGCACAAATAGC
AGGAGTCTAAGACCAGCCTGGCCAACATGGTGAAACCCCGTTTCTACTAAAGATATAAAAATTAGCTGGGCATGGTGGCAGGCACCTGTAGTCCCAGCTACTTGGGAGGCTAAGGCAGGTGAATCGCTTGAATCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCATTGCACTCCAGCCTGGGGGACAAGAGTGAGACCTCGTCTCAAAAACAAAACAGAAGGCTTAGTAACTGAGCTACCACAGCTTCAAGAAAGCAAAGGTGCAGTTTTAGCCAAGTACACACTATTCCATAAGAATGGGTGAGATCCAGTTGTAGGACAGGACACGGCAGGAGAGCTGTAAGGTTGAACACCTATGTGTACAAGTGTGTGGCTGCAACCTCAGAGCATCAGTGCTCAGATTCTAGAGTCAGATGGATATTCTAATACAAGCTCCATTGTTTAAGTATTGTTTTGGGCTGGTTATTTAGGCAGCAAGCTGGGGTTTCTTCATGAAAGACGAAGACTAGTACAACTAGTGGATGTGGAATACATAGCACTGTGCCTGGCATATGGTAGGTGTTCAGATGGATAGAGGCTAGAGACCAGTCTTTCCAGATGATCAACACCATAGTAGAGTCAGACTTTCTGGGGCTTTGGAACTCATTCCTTAAGATTCAAGAGGTGATTGGAAGGCAGCATGTGGCCAAGTGTGGTGGTTCACACCTGTAATCCCAGTACTTTGGGAGGCCAAGGTAGGTGGATCACCTGAAGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAGATAGCAAAAATTAGCTGGGCTTGGTGGTGTGCCCCTGTAATCTCAGCTACCCAGGAGGCTGAGGTAGGAGAATTGCTTGAACCCAGGAGGCAGGGGCTACAGTGAGCTAAGATCATGCCGCAGCACCCCAACCTGGGTGACAGAATGAGACCCCATCTCAAAACAAAAAAAAAAAAAACAGAAGGCAGAAGAGTCCCAATTAGAAAACAAGGACTAAATCTGGATCTCACATGACTGAATGCTGCTCTAAAGCCCAAGAGGGTTTATTCCCATTACTGGCAAGTTTTGATGGATTAGCTGGGTAACCTGATAGTACAGGGAGTACCTACCCATCCACGACAACGTTCCACTGGGGGAAAGAGTCTGGATCCATGGTGGACGTCGCCCAGCAGTCATCTAAGACCAGCTTGATGTTGGGGTCATCCCTGTTTAGGACTCTCACTTCCATGTAAATTGGTTGGCGGAGGAATCTCACTAGAGGGTACTCGTTTTCCCCATAAGGTTGTTGGTAGGAATTATCTGAAATTGAATGGTATTCAAGTAGTTAATGGCTGCAACACAGATTCATAGGTCATCACTGCTCCATTAGTCTGGCAGTATCAGGATGTTCATTTTAGGGAGAAGTTTGAGATCATTTAAGCAATTTCACAGACTGCAATCTCTTACCTGGGTAGCTTTGCAGGATCAAGGTAAATGGACCCAACTTCACTGAGGCCACTGGAGGAGTAAGGCTTTCAACGTTGATGTTTAGTAGCATGTCATTCCTGCTATAAGAACACTTCACTGTCATTCTGTAAGAGTTTGGAGGGAAGGTAGGTACAGAAAATTTCAGGTTAAAAAATTGCTTGAGTTTAAACTAGAGCTTAAGAGTCAAATAGCAATTTTATCTCACCTGAACTCACTGTCTCTAGATATTTTGCTTGGAGGAAAATCCGTCCAGAGAGCATGTATTTCGTTTTCATAGACGACTTTATCATCTTCGAACTTAAATGTCAGAGAAAGTGGGTTAGCAGCCAGTTATGTCAAAGATGAGACTTAACCTCGTGCCATCTGCCAGTACTAACCTTATATCTCGTTCCACATCCATTCAGGGGTATGTGGAACCGTACCAGCCCCTGAGACTGAGCCTCAAAGACAGGCTGGCAGGATGAGTTTCCCACCCTCAGAGTACCCAGGTCAAGAGCTGGTTGTGTTTGGTAGCTGTAGACCTCGACGTCCATAAACCCATCCTGGGTGGACAGCTCCCCTGTAACTAGACAGCGGTGAAAGTTTAGAGAAAATAAGTTTGTCTGCCCTGTGATACTGTCATCTCCCAACCTGATATGCTACGAGGGAGAAATTCTAATTTAGCAGGAGGCATCAGAATCTGTCTTGAAGTCTTTATGAGGGAACCTTGATCAGCAGCTTGAATTACAAAGGGAGCTGAAGTTAGTTGATTGTTCTATGTGAGAGTAGGACTTTTCATCCAAAGGAGGGACCAGTAGATGTAGGAAGAAGTGCTATATGGTATAAGACCAGTGAGAATCCTGATGAAGGGCAGGAGTTGACTCAAGGTTAAACTTAATGTGGCTTTAAGTACAGCGCCTATGTTATTGTATCCTTTCTTTGTATACTCACAAATCCTGAGTAGTTTGGGGAGAAACTGAGGCAGGAGCTGGTTTTCCTATTTGATCTGACCTGTGCAGATCACATTAAACAGAAGCACATGGTGGAGGCAATGCTAAACAAGAGATATTCACTCTATTTAAGAATTTGTAGGAATTTTGGGGTGGGGGGGTACTTAAACTTAATTCTAATTAGAAGTTTGAATATTCTTACCTAGATGTCAGGTTCAGGCTCCTAAGCCAAAATATCTAGATTGTTTAACCATGGAGCAGTTGCCATAAAACCTACCTATGTAGGGATCTTAAAAATATCATACTTAGGACCCCATCGTAGCAGCTACACTGTTTCTAATCTGACTAGTCTTTAGTTTCTTCAGTCTATAAGCAATAGATCAGAATCTGACCTTCTATACATTTGCCCACATGTACAAGAGCCAAGGGAGAAAAAAGGTAGAACATGATTTTAATAAAAGGTCTTTACCTATAGAAACGGGTGACTCACAGAGACACTCAGGATAGATCACCATGGATACTGTCTCTGGCCGAAGGAGAAAGGTCAGCTTGAGTGAAGCTAAGTAGAACTGATGGAGTAGGCATTTTTCAGATAACTGAAATGAGAAAATGTCAATTAGCAGCCACAGTCCGTTGGGGCCCGGAACCGTCACAGGGAGGCAGGAAGCAAGTCCACTAAATACTTGCAGGACACACTCCAGACTTATCTGGGCTCCCTTTAAACCAAAACAAGAGAGACCCTATCACTTCCTCAGATCTGGATGTATCCCCAGGCAGATTTATTGCTTTAAACTCATGCCCTGGAGTACCCAGCACTGTACTCTTTGTACGAGGCACTAAAGCTTGAATTAGCAGATCAAATTCCAAAGAATAGTGGAATCCTCTGCCAAGCCAGGTCTGAGTCAAAAGGACTCTACAGATGTTATAAAATGGTATTGCATAATATGTACCCCCAACCTAAGATTATTCTCTGGTATCCCTGGCAGTTCTAGTGAAGACTAACCTCAACAGCAACAGTACGGGACCCTTTTGTTTAGATCAAGGTGTCCTGTTCGTTGACCAGGACAGATTCATCATTAGGTATTTGACAAGTAGTTGCTACTACTCAGTTGGGGCCTTAGACAGTTTTAAGACTTAGAAAGACTTAGACGATTTTTCATGACAGAAGTTAAAGAGGTTTTGTGTTAGAGAATGAACTTTAGTTACTTGATATTTCACTTATACAAGATGATCAAATGAGGCCTTTTGGAGTTTGAATCTGTTATGTTGGCAATTAGAGCTCACGGGCAAGTTATCAGCCGTATGAGGACTACCCACAAGAGTATACTTCAAGTCAGGACCCGGTGGAGTTCAGTGGTTGACAATTGAACATACTTTCGTTTTGAGCAGAGTTTTGCTGAAATGCAATTTCATGCCATTTGTTGCTTCTAGATCAATTCCATTGTCATGCAGCTGGCTCACATCAATGTTCTGGTTTTCAAAGCTCACAGACTTAAGCTTCCCAGGAAACTCTGGTATGGTGAGAGTCATGTGTGTGGCATTGCAGGTCACAGGATCTAGAAGGAATGACAACAGAATGCCCATTACCAGCCTTGATTAAGCTTCTAGGACAATGTCTCCCACACTGAGGTTGCAGCTATCTGGGACCTTACCTGGTGCACAAATAGC
Task1_train_22466
Located on Chromosome 16, this mutation impacts CRYM (crystallin mu). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Autosomal dominant nonsyndromic hearing loss 40
AGAAAAGATATATGAATATTCTCATCATTCCATGCTCTTCTCTATATATCCTTTAGGGTAGTGACCATCAGGATTCCTCAGAAAGACTCCATAGTCACTTGAGATATGCAGAATCAGATCATGTGGGTAATGTGGGTATTTTGTTTCAGCACAAAGACCCCTGTCCAGACAGTCTGGCAAATATGATAAACTTTTGGCTAAACCATCTGGAGCATGAGTCCTTCCCAGGAGGAGTATGGTCAGGAAAACAGAGCCATGCTTTGCTGCTGACTTATCTGAAAACCAGCCTTGGAGTAGCAAAAAGCGAAGGGGTGGGGTGAGGCTAGGGTCGGAGTGGGATTTGGACAGGGCCTTTGGCAGGACAAGGACAACACGGTTCTGCTAGTGATTCAGGGGGCCTGGAGAAAGTATCTCTGCACCTCAGTTTCCCCATCCGTAAGTTGAAGATCGACTAGCTGATCCTTAATGGCCCTTTTAACATGGATACTGTAGTGGACATCTTTAGATTTTGCCTTTCAACTACCCAGTCCTCTTTTTGTTAAGAGACACCTTCCCTCCATCAGCTCATGTGGGCAGATGCGCAGATGACACTTCTGACTTCAAGGGTGGGCATGTGATCCAGGCCTGGATAACCAGAGCATCTGATCCCCCTGGACAACGTGATGGTTCAGGGATAGGTACAAGGCTTGAGCCTGGCCAGGGTATTCCATCTCTTTAAAAGATGGGGTCTTGCTATGTTGCCCAGGCTGGTCTCGAACTCCTGGGCTCAAGCAATCCTCCTGCTTCAGCCTCCCAAAATGCTGGGATTACAGGCATGAACCACCTCACCCCGTCTATTCCATGTCTTTCAGCCACAATGTTAGGCTCAGGAATAGACATGTGACCTAGATGGTCCAGTAACTCTCAGTTCTGGAACATCTAACTGTAAAGGAAGAGAATATTTATGCTCAGTTGCTAAAGAGGACAGAATACAATTCAGGAGCTGCTGACCAATGTCCTGCCACTACCAGGGAGAACTTGATAATGGAGCCAACGGGGAAGAAGACCAGGCCCTGGTGACAGTTGGAGCCCCTGAATACAGCTGTAGCTGAAACCAGTTACCTGTGTGTTCCTAATTACGAGAGCCAATAAATCTCATTCTCCATTCATTCAGCTTAAGGTAGTTTGAGTTGTAGTCTCTACCACTTATGACCAAAGGAGCCCTGATCTATACAGAAATTCCATTTTTCCTCTAAGCATTAAGGAGTCAGGCACAAAAGACTACATATAGTAGAATTTCACTTGTAAGAAATGACCAGGCTTGGCCGGGAGCCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGTCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGAGTGTGGTGGCGTGGCACCTGTAATCTCAGCTACTCGTGAGGCTAAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCATCGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAAAAAAAAAACACTACTGAATTGTATAGTTTAAACTAGTGGATCTTAGAGTATGTGAGTTGTAACTACTAAATAAATACATAAAAAAGAAGTTTCATTATAGCCAGTGTAGCTCCCCCAGGGAGTAAATGGGAGCATCTGATCCCTCTCAGTTTCCTTGTGATAGTAATAGAAGTTACCGAAGCAAACACTGCACAATTGGAATGTGCTTTATTTCAGGGAAATATAAAGGGAAATGAATGCTATTATAACTTGGTAGAACAGAAGAAATGGCTACCTAGCTTTGCTTTCCAACTACAAACATAAATGAGGATCTCAGCATTTAAGGTAAAACATGATAAGCACAAAAGGAGAGTTCACTGGGGACTGGACTCCCTCATTTACTCTAGAAATTATGAGAACCAGCAGCAATATTCCTCAAGCATCCATCTCAACATCAAGTTCCTTTGTTTTATTTACCAGATGACCAGGAATCATAGATGAGTTTGGCTGCAACTGTGTCTTCCACTGCCATTCCTAGAATAGACAGAAATTTGGTTCGCCTTTGGTCAAAACAACTTTTCTTGAAACAACCCAGGCCCCATGGCTGGAAGTTTCCTGATACATGTCCATGTTGCCAATGCCTATTGGAATAACAGGGACTGATACCCAGAGATGAGCTCAGGCTTCAATTGTCTGCAAAGGGGCAGAGAATATGATAGTAAGAAACACCCACCAACAAATTGTGCATCTTTCTAAATCTAGCTCAGGGCTGAGCAAATTTTTTTTTTTAATTTTTTTTTTTTTCGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGAAGTGCAGTGGCGCGATTTTGGCTCACTGCAAACTCTGCCTCCCAGGATCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCATGCCACCATGCCTGGCTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGACCAGGCTAGTTTCAAACTCCTGACCTCAGGCGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGCTTACAGGCATGAGCCACCACGCCTGGCCTGAACAAACTTTTCAAAAAGGGTCAGACAGTAAATCCTTTAGGCTTTGTGGGCCACAGGGTCTCTATTACAATTATTCAACTCTGCCTTTAGAGTAGAAAACACAGCCAACAGGTAAACAAAAGAGCCTGGCTGTGGGCTGTGTTCCAGTGAAATTATTGATGGGACTGAAGCTTGAATTTTGTATCATTTTCAGACATCATGAAATATTTTCTCCCCCCATTCATTTGAAAATCTAAAAACCATTTCTAGCTCATAGGCCACACAAAAGCAGGCAGCAGAGCAGGTCTGGCCCCAGGACTGTAGTTTTCTGACGCTTGGTCCAGTTTGAATGCTGCATCCTTTGATATCTCCCCTTTGTCTTGTAATTTTGGTAGATACCTTAACCTCTGCACCCAGCACAGATAATTAGGTGCTTGATACGCATCTGTTAGATGAAACAATGCACCAATAAACTGATCCCCAAAAGTAAGAAAGCAAAAATTGCCAAAAAGGACAGAACAAGTTTCTGCAGCATTTTGGCTCCTTAAGTAAGGGCTGGCTGACCTCTGATCTGCCATGACCTTTGAAGTTTTCAGACAAAACTGGATCCATGTGATGTCTTTGAACCAGGCTCCAGATAAAATTGTATTGCCTTTGTCTTCCAGTGCATGAGAGATTTTAAAGACATTTACCAACCTGCAAGGCATGGATACTTAACCAATGGCATGGGCTCTGGGTGGCCAGAGCGCTCCTGATGCTCTGCCAGGCATTTACTCTTTTGCTGCTTGATCACGAAGTATGGAAGGTCATGAGAGGGGGACAGAGGGCACTCTCGAGGGGCTCAGGATAGCAACTGTTTACCAACCAGTTTGGGAGTATTTCAGTGTTTTAGGTGTATCAGCTCTGTTCCCATGTACTTTATTTATTTATTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCACGATGTCAGCTCACTACAACCTCCACCTTCCGGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAAGTAGCTGGGATTGCAGATGTGCACCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTTAGCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGAGCTCAGCCTGTTCCCATGTACTTCTGTTTCCTTCAATCTCATAGGGTGGAAGAGGACCTGGGGCAAGGGACAGACTGGCCACTGGGAGCCCACCCTTTGTTGGGCTTCTATAAGGTACCCCATACAACTCAGGTGGTAGGGGGCTCCCCATGGAAGCCCTCCTCAAAGCAGCAAGTGGGAGAGTAGGGAAGGAGGGAATGAACAGGGCTTAGGCTATACTTTCCATCTGACTCTTTCAGGT
AGAAAAGATATATGAATATTCTCATCATTCCATGCTCTTCTCTATATATCCTTTAGGGTAGTGACCATCAGGATTCCTCAGAAAGACTCCATAGTCACTTGAGATATGCAGAATCAGATCATGTGGGTAATGTGGGTATTTTGTTTCAGCACAAAGACCCCTGTCCAGACAGTCTGGCAAATATGATAAACTTTTGGCTAAACCATCTGGAGCATGAGTCCTTCCCAGGAGGAGTATGGTCAGGAAAACAGAGCCATGCTTTGCTGCTGACTTATCTGAAAACCAGCCTTGGAGTAGCAAAAAGCGAAGGGGTGGGGTGAGGCTAGGGTCGGAGTGGGATTTGGACAGGGCCTTTGGCAGGACAAGGACAACACGGTTCTGCTAGTGATTCAGGGGGCCTGGAGAAAGTATCTCTGCACCTCAGTTTCCCCATCCGTAAGTTGAAGATCGACTAGCTGATCCTTAATGGCCCTTTTAACATGGATACTGTAGTGGACATCTTTAGATTTTGCCTTTCAACTACCCAGTCCTCTTTTTGTTAAGAGACACCTTCCCTCCATCAGCTCATGTGGGCAGATGCGCAGATGACACTTCTGACTTCAAGGGTGGGCATGTGATCCAGGCCTGGATAACCAGAGCATCTGATCCCCCTGGACAACGTGATGGTTCAGGGATAGGTACAAGGCTTGAGCCTGGCCAGGGTATTCCATCTCTTTAAAAGATGGGGTCTTGCTATGTTGCCCAGGCTGGTCTCGAACTCCTGGGCTCAAGCAATCCTCCTGCTTCAGCCTCCCAAAATGCTGGGATTACAGGCATGAACCACCTCACCCCGTCTATTCCATGTCTTTCAGCCACAATGTTAGGCTCAGGAATAGACATGTGACCTAGATGGTCCAGTAACTCTCAGTTCTGGAACATCTAACTGTAAAGGAAGAGAATATTTATGCTCAGTTGCTAAAGAGGACAGAATACAATTCAGGAGCTGCTGACCAATGTCCTGCCACTACCAGGGAGAACTTGATAATGGAGCCAACGGGGAAGAAGACCAGGCCCTGGTGACAGTTGGAGCCCCTGAATACAGCTGTAGCTGAAACCAGTTACCTGTGTGTTCCTAATTACGAGAGCCAATAAATCTCATTCTCCATTCATTCAGCTTAAGGTAGTTTGAGTTGTAGTCTCTACCACTTATGACCAAAGGAGCCCTGATCTATACAGAAATTCCATTTTTCCTCTAAGCATTAAGGAGTCAGGCACAAAAGACTACATATAGTAGAATTTCACTTGTAAGAAATGACCAGGCTTGGCCGGGAGCCGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGTCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGAGTGTGGTGGCGTGGCACCTGTAATCTCAGCTACTCGTGAGGCTAAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCATCGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAAAAAAAAAACACTACTGAATTGTATAGTTTAAACTAGTGGATCTTAGAGTATGTGAGTTGTAACTACTAAATAAATACATAAAAAAGAAGTTTCATTATAGCCAGTGTAGCTCCCCCAGGGAGTAAATGGGAGCATCTGATCCCTCTCAGTTTCCTTGTGATAGTAATAGAAGTTACCGAAGCAAACACTGCACAATTGGAATGTGCTTTATTTCAGGGAAATATAAAGGGAAATGAATGCTATTATAACTTGGTAGAACAGAAGAAATGGCTACCTAGCTTTGCTTTCCAACTACAAACATAAATGAGGATCTCAGCATTTAAGGTAAAACATGATAAGCACAAAAGGAGAGTTCACTGGGGACTGGACTCCCTCATTTACTCTAGAAATTATGAGAACCAGCAGCAATATTCCTCAAGCATCCATCTCAACATCAAGTTCCTTTGTTTTATGTACCAGATGACCAGGAATCATAGATGAGTTTGGCTGCAACTGTGTCTTCCACTGCCATTCCTAGAATAGACAGAAATTTGGTTCGCCTTTGGTCAAAACAACTTTTCTTGAAACAACCCAGGCCCCATGGCTGGAAGTTTCCTGATACATGTCCATGTTGCCAATGCCTATTGGAATAACAGGGACTGATACCCAGAGATGAGCTCAGGCTTCAATTGTCTGCAAAGGGGCAGAGAATATGATAGTAAGAAACACCCACCAACAAATTGTGCATCTTTCTAAATCTAGCTCAGGGCTGAGCAAATTTTTTTTTTTAATTTTTTTTTTTTTCGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGAAGTGCAGTGGCGCGATTTTGGCTCACTGCAAACTCTGCCTCCCAGGATCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCATGCCACCATGCCTGGCTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGACCAGGCTAGTTTCAAACTCCTGACCTCAGGCGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGCTTACAGGCATGAGCCACCACGCCTGGCCTGAACAAACTTTTCAAAAAGGGTCAGACAGTAAATCCTTTAGGCTTTGTGGGCCACAGGGTCTCTATTACAATTATTCAACTCTGCCTTTAGAGTAGAAAACACAGCCAACAGGTAAACAAAAGAGCCTGGCTGTGGGCTGTGTTCCAGTGAAATTATTGATGGGACTGAAGCTTGAATTTTGTATCATTTTCAGACATCATGAAATATTTTCTCCCCCCATTCATTTGAAAATCTAAAAACCATTTCTAGCTCATAGGCCACACAAAAGCAGGCAGCAGAGCAGGTCTGGCCCCAGGACTGTAGTTTTCTGACGCTTGGTCCAGTTTGAATGCTGCATCCTTTGATATCTCCCCTTTGTCTTGTAATTTTGGTAGATACCTTAACCTCTGCACCCAGCACAGATAATTAGGTGCTTGATACGCATCTGTTAGATGAAACAATGCACCAATAAACTGATCCCCAAAAGTAAGAAAGCAAAAATTGCCAAAAAGGACAGAACAAGTTTCTGCAGCATTTTGGCTCCTTAAGTAAGGGCTGGCTGACCTCTGATCTGCCATGACCTTTGAAGTTTTCAGACAAAACTGGATCCATGTGATGTCTTTGAACCAGGCTCCAGATAAAATTGTATTGCCTTTGTCTTCCAGTGCATGAGAGATTTTAAAGACATTTACCAACCTGCAAGGCATGGATACTTAACCAATGGCATGGGCTCTGGGTGGCCAGAGCGCTCCTGATGCTCTGCCAGGCATTTACTCTTTTGCTGCTTGATCACGAAGTATGGAAGGTCATGAGAGGGGGACAGAGGGCACTCTCGAGGGGCTCAGGATAGCAACTGTTTACCAACCAGTTTGGGAGTATTTCAGTGTTTTAGGTGTATCAGCTCTGTTCCCATGTACTTTATTTATTTATTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCACGATGTCAGCTCACTACAACCTCCACCTTCCGGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAAGTAGCTGGGATTGCAGATGTGCACCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTTAGCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGAGCTCAGCCTGTTCCCATGTACTTCTGTTTCCTTCAATCTCATAGGGTGGAAGAGGACCTGGGGCAAGGGACAGACTGGCCACTGGGAGCCCACCCTTTGTTGGGCTTCTATAAGGTACCCCATACAACTCAGGTGGTAGGGGGCTCCCCATGGAAGCCCTCCTCAAAGCAGCAAGTGGGAGAGTAGGGAAGGAGGGAATGAACAGGGCTTAGGCTATACTTTCCATCTGACTCTTTCAGGT
Task1_train_22467
This variant affects gene OTOA (otoancorin) located on Chromosome 16. Evaluate its biological effect and specify any disease association.
Pathogenic; Autosomal recessive nonsyndromic hearing loss 22
CATTGTTATTAACTGTAGTCAGCATGTACAATAGATCTCCAGAACCTATTTTCCTATTTAACTGAAACATTGTGTCCTTTGTCCAAGTCTCTCCAACTCCCTTCCCACCTCCAGCCCCTGGTACCAACCATTCTAAGGCTCTGCTTCCATGAGTATGACGTTTGTTTATTTGTTTTTCAGATTCATAATATAAATGAGGTCATACAGTATTTGTCTTTCTGTGCCTAGCTTATTGCACTTAGCATAAGATCCTCCAAGTTCATCCATGGGGTCCCATATGATAGAATTTCCTTCTTTTTCAAAGCTGAAGAGCATTCCATTGTGTATCCACCAAATTAAAAAAAAAATCCATTCATCCACTGACGTGTTGGACACTTAGGATGATTCCATGTCTTGGCTGTTGTGAATAGTTATTCTCAACGTGGTTATTAACGTTCAGCCCTCACTTCCCCTGAGTCTTCTTTACTCGAAGTTAAGCAGATCTCTTTTCCTCATGAGACACACTTTCAAATCTTTTCCCTGGACCTGGCAGCTCTCCTGTGGGCATGTCTGAATATGTCAATATCGCTCTGAGAGGGTGGAGCCAGGCTGACTGTGGTCAACTAGGTAGTCTTCATTCTAACTCTAAGAGCATTCATTAATGAATGAGTGCTTGGTTTCCACCAGGATGTATGCAAATCAGTTGGTATACCACTTCTCATTTAACTTTCACAATCATCCTCTTTCTTTCACTCATGTTTATTATGATGTGCTACGATGAACAAAGAAAACCTCCCATTTATTAGAGGCTCAGAGAGGGAGAGGCACCCTGTCTCTGTACAGTATGGGAGTACAGAGTGTGCACTGCAGAACTGTGTATAGCGGCCTCACAGAGAAGTTAAGTAACTTGGTGGAGAGCAAACATCTCACAGAGCTGGGCTTCAAACTGCAGTAGGCCTGAATCAATGCTCTTAATGATTAGAAACATTGCTCTCAGTTATACCAGGGTTCCAATCTCACTTCTGCCCTTCCATTGTTTTCCTCCAGTCTTTTTTGTTTTCCTTCTGAAATCTTTGCATCATCTGGGTGGGTACCAGAAGGCATCCTAGAAACAGATCTCTGCCTCAGAGAATCCCTCAGGGTGAGATCAGCTCTAGAATTTAGTGATTGTAATGTGGAAAATGGGGAGTTTTCTGTGGCTACCGGCACCTTTCTTTCCTTATTCCCTTTATTCATCCCAGGTGGAGAGATGGCATAGGTGGATGGATCTACATTTAAGTCCCAGCTCCACCGACTTGCCTTGGACAAATCAAATCTCAGTTTCCCCATCTGTGAAATGGGGCTAATGAGAGCACCTGCCTTGTAGGGTTGCTGTAATGAGATAATGCAGGTAAACGGCTCAGTGCAAGACCTGATAAGTGGTAGCTGCTATTAATATAATCAAGACCCCATTGGTTTGGACTGGGGAGGGGGTGTCGTGTCCACCAGCTCTCAGCGCTCTGTTATGGAACCAAACTGGGTCTGTTTGCCCATGCGCAATGGAAAACCAAACACTGAAGCACTAGGTTTTTGTAGAGAGAAACGGTTACTGTGAATCAACTGCCAAGGAGACAGAAGACAGTGCTCAAATCTGTGTCTCTGAGCTGGGGACTGGGGCAGGTTTTATAGGCGGAGGGTAATGAGACTTGATCTGATTGGGTCTTGCTACAAGGTGATGCTGGGAGGTGTGATCTGATTGGATCATGCCATGAGGTGATGCCAGGACTCATTCTGATTGGATCGTGGACCATGCCATGTGGTGTCCACTTCATAATTCAGCCCCCATTCCTTGGTCTCGTCTGAGCAGTTAGGTTCCGCCTGTGGTTGCACATTTGGTTCATCTGAGGATGTTCAGGTTATGTGACCTTCAACCTGGGAGTCCGTGGCAACTGAAAAACAACTCACCATTTTATTACACAAAATTGAACCAGAATGGGCTGGTTCTGCGGTTACACCTCCACCACCATCCCTCCTCTTCTCACACAGGCTGGGGCTGCTGGTTTGTTTCTACAATGACCTGGAATTGCTGGATGCCACTGTGGCTCAAGTCCTGCTTTACCAGATGATCAAGTGCAGCCACCTGAGGGGCTTCCAGGCTGGCGTCCAGAAGGTACAGCTGGGGTGCAAGGCCCTGAGGCCTCTGCCTCAGTGTCACTAGCCAGAGAAATGGGGAGAACAGCCTAGCTTAGCCTTTGGGAGAAAACACACAGCATTAGTCGGGATTTAAGTCCAGTCACAGCAGATGGCATCTCAAATACTGAGGTAAGTGTAACATCGAAGCCCAGACAGAAAATAGCAAAGGAACAGACCCTGGGGAGATCAAAATTTAATCAGAAAGCTGTCTCAGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGATGGGAGGATCATTTGAGGCCAGGAGTTTGATACCAGCCTGGTCAACATCATGAGACCCTTGTCTCTGCAAAAAATACAAAAAAATGGCTGGGCACGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGTCAGTTTGAGACCAGCATGGCCAACATGGTAAAACCCTGTCTCTACTAAAAATACAAAAACAGGCGTGGTGGCATGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAGCCTGGGAGGCAGAGGTTGTGGCGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAGAAAAAAAAAAAAGCCATGTGCCTATAGTGCCAGCTACTTGGGAGGCTGAGGTAGGAGGATCGCTTGAGCCCAGGAGTGCCAGCCTGCAGTGAGCTATGATAGTGACTTTGCACTCTAGTTGGATGACAGAGCAAGACCCTATCTAAAAAAAAGAACAGAAAAGAAAAGAAAGGGACAGCTACTTCGAACTTAAATATGCATACAGATCACCTGGGGATCTTAAATGCAGATTCTGATTCAGGAGCTCTTGGTTGAGGCCCAGGACTCCCATCTTCCTCTTCTTCCTCCTTCTTCCCTTGGCCTCCCAAAGTGTTTGGATTACAGGTGTGAGCCATTGCGCCCAGCTGACGCTGCACTTCCAACAAGCTTCCAGGTGATTCTGGAACCGCTGCTCTGGTGAGCACACCTGGAGCGGCAGGAGATAAAGCAGTGGTTCTCAAACCTGCCTCTAGATTAGTAACATCCCTGCCAGGTGCCACCCTCAGAGAATCTGATGTTATTGTTCTGGGGTGTGGCCTGAGGTATGGCCTGATTTTAATGCTTCTCAGGTGATTTCAATGCAGCCAGGATTGAGAACACTGGATTGCAGGGTGGTTATGAGTTCCCAAGACCAGATGAGCAAACACGCTCTCTCTCATTTTCCTTCCTCTCCATCTCTCTCTTCTTCCTTCCAGTCAAGTCTCAATTCTACCCCCTTCCATTCCACTTTTTGTGGCCCTTTTCAATTTGCTTAAAATCGAAACGATGACATGAAAATAATATTAAATGAAATTTTGATAAAGCCATCAATAATTTCACAGCAGTTTCCCACACATCACCATAAAGTCCCCAAACACATTTGACATTTGAGAGTGTGGTCATCTATTTTGGTCAGCGCATCTTTTTTTTTTTTTTTATAAGATTCATTTTTTTTTTTTTTTGAGTTTCATTCTGTCACCCAGGCTGGAATGCAGTGGCATAATCTCAGCTCACTGCAACCTCCACCTTCCGGGTTCAAGTGGCACAATTTCAGCTCATTGCAACCTTCGCCTTGCCTCAGCCTCTGGAGTAGCTGGGACTACAGGTGCATGCCACCATGCCCGGCTAATTTTTTGTGTTTTTAGTAGAGATGGGGTTTTACCATGTTGACTAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTTGGCCTCCCAAAGTACTGGGATTACAGGCGTCAGCCACCGAGCCTAGCCTGTGAATGCATATTTTTGTTTCCAAGGAAAAGAATCCGTCCTAAGCAAGCTCAAGCAAAAATAAGAAGATAAATGTATTTTAAGGCCCAGGGGTCT
CATTGTTATTAACTGTAGTCAGCATGTACAATAGATCTCCAGAACCTATTTTCCTATTTAACTGAAACATTGTGTCCTTTGTCCAAGTCTCTCCAACTCCCTTCCCACCTCCAGCCCCTGGTACCAACCATTCTAAGGCTCTGCTTCCATGAGTATGACGTTTGTTTATTTGTTTTTCAGATTCATAATATAAATGAGGTCATACAGTATTTGTCTTTCTGTGCCTAGCTTATTGCACTTAGCATAAGATCCTCCAAGTTCATCCATGGGGTCCCATATGATAGAATTTCCTTCTTTTTCAAAGCTGAAGAGCATTCCATTGTGTATCCACCAAATTAAAAAAAAAATCCATTCATCCACTGACGTGTTGGACACTTAGGATGATTCCATGTCTTGGCTGTTGTGAATAGTTATTCTCAACGTGGTTATTAACGTTCAGCCCTCACTTCCCCTGAGTCTTCTTTACTCGAAGTTAAGCAGATCTCTTTTCCTCATGAGACACACTTTCAAATCTTTTCCCTGGACCTGGCAGCTCTCCTGTGGGCATGTCTGAATATGTCAATATCGCTCTGAGAGGGTGGAGCCAGGCTGACTGTGGTCAACTAGGTAGTCTTCATTCTAACTCTAAGAGCATTCATTAATGAATGAGTGCTTGGTTTCCACCAGGATGTATGCAAATCAGTTGGTATACCACTTCTCATTTAACTTTCACAATCATCCTCTTTCTTTCACTCATGTTTATTATGATGTGCTACGATGAACAAAGAAAACCTCCCATTTATTAGAGGCTCAGAGAGGGAGAGGCACCCTGTCTCTGTACAGTATGGGAGTACAGAGTGTGCACTGCAGAACTGTGTATAGCGGCCTCACAGAGAAGTTAAGTAACTTGGTGGAGAGCAAACATCTCACAGAGCTGGGCTTCAAACTGCAGTAGGCCTGAATCAATGCTCTTAATGATTAGAAACATTGCTCTCAGTTATACCAGGGTTCCAATCTCACTTCTGCCCTTCCATTGTTTTCCTCCAGTCTTTTTTGTTTTCCTTCTGAAATCTTTGCATCATCTGGGTGGGTACCAGAAGGCATCCTAGAAACAGATCTCTGCCTCAGAGAATCCCTCAGGGTGAGATCAGCTCTAGAATTTAGTGATTGTAATGTGGAAAATGGGGAGTTTTCTGTGGCTACCGGCACCTTTCTTTCCTTATTCCCTTTATTCATCCCAGGTGGAGAGATGGCATAGGTGGATGGATCTACATTTAAGTCCCAGCTCCACCGACTTGCCTTGGACAAATCAAATCTCAGTTTCCCCATCTGTGAAATGGGGCTAATGAGAGCACCTGCCTTGTAGGGTTGCTGTAATGAGATAATGCAGGTAAACGGCTCAGTGCAAGACCTGATAAGTGGTAGCTGCTATTAATATAATCAAGACCCCATTGGTTTGGACTGGGGAGGGGGTGTCGTGTCCACCAGCTCTCAGCGCTCTGTTATGGAACCAAACTGGGTCTGTTTGCCCATGCGCAATGGAAAACCAAACACTGAAGCACTAGGTTTTTGTAGAGAGAAACGGTTACTGTGAATCAACTGCCAAGGAGACAGAAGACAGTGCTCAAATCTGTGTCTCTGAGCTGGGGACTGGGGCAGGTTTTATAGGCGGAGGGTAATGAGACTTGATCTGATTGGGTCTTGCTACAAGGTGATGCTGGGAGGTGTGATCTGATTGGATCATGCCATGAGGTGATGCCAGGACTCATTCTGATTGGATCGTGGACCATGCCATGTGGTGTCCACTTCATAATTCAGCCCCCATTCCTTGGTCTCGTCTGAGCAGTTAGGTTCCGCCTGTGGTTGCACATTTGGTTCATCTGAGGATGTTCAGGTTATGTGACCTTCAACCTGGGAGTCCGTGGCAACTGAAAAACAACTCACCATTTTATTACACAAAATTGAACCAGAATGGGCTGGTTCTGCGGTTACACCTCCACCACCATCCCTCCTCTTCTCACACAGGCTGGGGCTGCTGGTTTGTTTCTACAATGACCTGGAATTGCTGGTTGCCACTGTGGCTCAAGTCCTGCTTTACCAGATGATCAAGTGCAGCCACCTGAGGGGCTTCCAGGCTGGCGTCCAGAAGGTACAGCTGGGGTGCAAGGCCCTGAGGCCTCTGCCTCAGTGTCACTAGCCAGAGAAATGGGGAGAACAGCCTAGCTTAGCCTTTGGGAGAAAACACACAGCATTAGTCGGGATTTAAGTCCAGTCACAGCAGATGGCATCTCAAATACTGAGGTAAGTGTAACATCGAAGCCCAGACAGAAAATAGCAAAGGAACAGACCCTGGGGAGATCAAAATTTAATCAGAAAGCTGTCTCAGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGATGGGAGGATCATTTGAGGCCAGGAGTTTGATACCAGCCTGGTCAACATCATGAGACCCTTGTCTCTGCAAAAAATACAAAAAAATGGCTGGGCACGGTGGTTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGTCAGTTTGAGACCAGCATGGCCAACATGGTAAAACCCTGTCTCTACTAAAAATACAAAAACAGGCGTGGTGGCATGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAGCCTGGGAGGCAGAGGTTGTGGCGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAGAAAAAAAAAAAAGCCATGTGCCTATAGTGCCAGCTACTTGGGAGGCTGAGGTAGGAGGATCGCTTGAGCCCAGGAGTGCCAGCCTGCAGTGAGCTATGATAGTGACTTTGCACTCTAGTTGGATGACAGAGCAAGACCCTATCTAAAAAAAAGAACAGAAAAGAAAAGAAAGGGACAGCTACTTCGAACTTAAATATGCATACAGATCACCTGGGGATCTTAAATGCAGATTCTGATTCAGGAGCTCTTGGTTGAGGCCCAGGACTCCCATCTTCCTCTTCTTCCTCCTTCTTCCCTTGGCCTCCCAAAGTGTTTGGATTACAGGTGTGAGCCATTGCGCCCAGCTGACGCTGCACTTCCAACAAGCTTCCAGGTGATTCTGGAACCGCTGCTCTGGTGAGCACACCTGGAGCGGCAGGAGATAAAGCAGTGGTTCTCAAACCTGCCTCTAGATTAGTAACATCCCTGCCAGGTGCCACCCTCAGAGAATCTGATGTTATTGTTCTGGGGTGTGGCCTGAGGTATGGCCTGATTTTAATGCTTCTCAGGTGATTTCAATGCAGCCAGGATTGAGAACACTGGATTGCAGGGTGGTTATGAGTTCCCAAGACCAGATGAGCAAACACGCTCTCTCTCATTTTCCTTCCTCTCCATCTCTCTCTTCTTCCTTCCAGTCAAGTCTCAATTCTACCCCCTTCCATTCCACTTTTTGTGGCCCTTTTCAATTTGCTTAAAATCGAAACGATGACATGAAAATAATATTAAATGAAATTTTGATAAAGCCATCAATAATTTCACAGCAGTTTCCCACACATCACCATAAAGTCCCCAAACACATTTGACATTTGAGAGTGTGGTCATCTATTTTGGTCAGCGCATCTTTTTTTTTTTTTTTATAAGATTCATTTTTTTTTTTTTTTGAGTTTCATTCTGTCACCCAGGCTGGAATGCAGTGGCATAATCTCAGCTCACTGCAACCTCCACCTTCCGGGTTCAAGTGGCACAATTTCAGCTCATTGCAACCTTCGCCTTGCCTCAGCCTCTGGAGTAGCTGGGACTACAGGTGCATGCCACCATGCCCGGCTAATTTTTTGTGTTTTTAGTAGAGATGGGGTTTTACCATGTTGACTAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTTGGCCTCCCAAAGTACTGGGATTACAGGCGTCAGCCACCGAGCCTAGCCTGTGAATGCATATTTTTGTTTCCAAGGAAAAGAATCCGTCCTAAGCAAGCTCAAGCAAAAATAAGAAGATAAATGTATTTTAAGGCCCAGGGGTCT
Task1_train_22468
A variant has been detected on Chromosome 16 in PDZD9, UQCRC2 (PDZ domain containing 9| ubiquinol-cytochrome c reductase core protein 2). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Mitochondrial complex III deficiency nuclear type 5
TCAACAAAAAAGGTTGTGGATGGGGTGATCTGACACTTTTTCAAAAAATGCCAAAGCTTTAGAACTACACAGAACCATGAAACTTTTATAAGGTAACTGAAAGATAAGAAAATACAGTGATTCTTTACATCATTTAAAAAATAAGCATCAAGAACTCTATAAATCACTAATAAATAGAGGTTTAAGAATGGCTTGGGTAAACTGGTGGGTTAGTAAGTCCATAATAAGTTATGCAGCTAGGCGGGGTGCAGTGGCTCACGCCTGTAATTCCAACACTTTGGGAGACCAAGGTGGGCAGATCACTTAAGATCAGGAGTTCAAGACCAGCTTGGCCAACACAGTGAAACCCCATCTCTACTAAAAAATACAAAACAAAAACTAGCTGGACATGGTGGCACGCACCTGTAATTCCAGCTATTTGGGAGGCTAAGGCAGGAGAATGGCTTGAACCCAGGAGGTAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGAGCGACAGAGAGACACTCTGTCTCAAAAAAAAAAAAAAAATGTTATGCAGGTAAATCCTCCCATGGAGGTGGTTATTGCTCCTTCCACCCCCGAACACCCTCTGTCGCTTGGGTACCCTAAGATACCATGCTTTTATATAAAGCACTGTTCTTGTGAGAAATACGTGTAACCTGTGTTTTTTATGTTTAGAGATTTTATTCCCTCAAAGTTGCCCCCAAAGTTAAAGCCACAGCTGCGCCTGCAGGAGCACCGCCACAACCTCAGGACCTTGAGGTTAGTCCCACTAACTTGCTCGCTGGAAGCTATACATGCCTTACTCTCCTTGGTAATACGAAGACATTCATTATATCTCTACTTTATTTTAAATACAGTTTACCAAGTTACCAAATGGCTTGGTGATTGCTTCTTTGGAAAACTATTCTCCTGTATCAAGAATTGGTTTGTTCATTAAAGCAGGCAGTAGATATGAGGACTTCAGCAATTTAGGAACCACCCATTTGCTGCGTCTTACATCCAGTCTGGTGAGTATCTTCACTTCCTCAAGTGTTTGGAAATGCTGTGGTATCTTGGTCCTGTGAAAAAGAAAAACTAAGATCAATGTCTTTATATTTTGATTCCTTGACCTGCCATAACAAATTACCACGGACTGGGTAGCTTAAACCAAATAAGTTTATCCTGTTACAGTTCTAGAGGCTAGAAGTCCAAGTCAAGGTGTCTAAGCCAAGCCAAGATATCAGCAGGGCTGTGATCCCTCTAAAGGTTCTAGGAAGGCACAAATCCTCCCCTGCCTGTTCCTAGCTTCCAGCAGTTGCCCACAACCCTTCATGTTCCTTGACCTGCAACTGCATCACTGCAGTCTCTGCCTTTGTTGTCACATGGCCTTCCTTCTGTCTGTGTCCACATTTCCTCCTGATAAGGATACCAGTTACATTAGATTTAGTGCCCACTATAATTCAATATGATGTCATCTTAAGTACTTAAATCTGCAGAGACCTTATTACCAAATAAAGTAACATGCAAATATTCTGGCTGGACATAAATTTGGGGGGGAACACTGTTAAACCCAGTACTGTCCCCTAATGTAAAATGAGAAACCACAAGATATTTGCCACAGAGAAGCACTAAATTAGTATCCATATGAATGTTGATGTTAGAGCATAAGAAATCAGTAAACAAATTTTTAACAGGAAGTGCCGCAAATTGAAAGAAAATTAACTCTTTTTTTCCCATATACAAGTCTCTTTCAGAATAGACTAATGAATCCAGTAAGCTTGTATTTGACAGTGGAAATTTTACATGAATGTACTTAATGTAAAAATGTATACTTAAGCTTTTTGTTGAGCCTTGTTTTATAATTCTTAACTAAAAAGGATGCAGGAATTTAGTAAAATTCTTTTTAAATCTGCTCACAACAGATTTTGATATAGTGTGATGTTTGGCAAACTTGGCATTGAAAAGCTACAAAGATAATCATTCTTTCTTTTTCAAGACGACAAAAGGAGCTTCATCTTTCAAGATAACCCGTGGAATTGAAGCAGTTGGTGGCAAATTAAGGTTTGTTAAATAAGTAATAGAAAATAGTGAAAATGCCAGAAAATATTCAATTTTAAGGGAACTTTTCTCTGTTATCAAGGAGGTTGAGGATTTCTTAAGCAACATAAGAAGGAAAAGACTGATGAATTTGAGTATATCAAACTGTAAAACATCTTTATGTCTTAAAGTAAAAATTTAAGTAACTGTCTGGGAGTAGATATCTGCAATATATAGGCATACCTCAGAGATGTTGCAGGTTCTGTTCCAGACCACCACAATGAAGGGAATATTGCAGCAAAGCAAGTCATAGGAATTTTGTGGTTTCCCAGTGCATATAAAAGTTATGTTTACACTATACTGTGGTCTACTAAGTGTACAATGACATTTTGTCTTGGAAAAAAAGTACATAACCTTAATTTTAAAATATTTTATTGCTTTAAAAATGTTAACAGTTATCTGAATCTTCAGCAAGTCATAATCTTTGCTGGTGGAGGGTCTTGCCTCCACGTTAATGGCTGATGACTGATCAAGGTGGTGGTTGCTGAAGGTGGTGGTGACTGATAATTTCTTAAAATCAGACAACAGTGAAGTTTGCTGCATTGATTGACTCTTCCTTTTGTGAAAGACTTCTCTGTAGCATGAGATGTTGTTTTTAGCCGTTTACCCACAGAACTTCTTTCAAAATTAGTCAGTCATCTCAAACCTTACCACTTTTTTATCAACCAAGATTATGTAATATTCTTTTTTATCATTTCGACAGTGTTCACAGCATCTTCAACCAGGAGCAGATTCTATCTCAAGAAACCACTTTGTTTGCTCATCCATAAGAAGCATCTCCTCATCTGTTCAAGCTTTATCATAAGATTGCAGCCATTCAGTCACATCTTCAGGCCCCACTTCTAGTTCTCTTGCTACTCCCACCATAGTTGCAGTTTCTTCCCCCTCTGAAGTCTTGCCTCTCAGAGTCATCCATAAGGGTTGGAATTGGCTTCTTCCAAACTCACGTTAATGTTGATACTTTGACATCCTCCCATGAGTCACAAATGTTCTTAATGGTGTCTAGAATGGTGAATTCTTTCCAGAAAGTTTTTTAATTTACTTTGCCCAGATCCATCAGCGTCTTCACTATCTGTGGTAGCTGTAGCCTTACAAAATGTATTTCTTAAATAATAAGACTTGAAAATAAAAATTACTCCTTGATCCATGGGGTGCAGAAGGGATGTTCTATTAGCAGGCATGAAAACAGTGTCAATCTCCTTGTACATCTGCATCAGAGCTCTTGGCATTGTTGCAGTAATAATTTGAAAGGAATCTTTTTTCTGAGCAATGGGCTTAAAATATTCAGTCAACCATGCTATAAACAGATGTACTATCATCCAGGCTTTTTTGTTCATTTACAGAGCATAGGCAGAGTAGATTTAGCATAATTCCTAAGGGCTCTAGGATTTTGAGAATGGTAAATGACCTCATCCTAAAGTCACCAGCTGCATTAGTCCCCAACAAGAGTCAGCTTGTCGTTTGAAGCTTTGACGCCAGGCATTGACTTCTCTAGCTACGAATGTCCTGGACGGCATCTTCCAATGTAAGGCTGTTTTGTCAGCATTGAAAATCTGTGGTTTAGTGTAGCCACCTTCATCGATGATCTTATGTAGATCTTCTGGATAACGTGCTGCAGCTTCTATATTAGCATTTGCTGCTTCACTGTGTACTATTATATTAAGAAGATGGCTTCTTTCCTTAAAGCTCATGAACTAACCACGGCTAGCTTCAGACTTTTCTTCTGCATCTCACCTCTCTCAGCCTTCATATAATTGAAGAGAGTTAGGGCATTGCTCTGGATTAAGCTTTGACTTAAGGGAATACAGTTTGATCTAATCCAGACCAGTAAAACTCTGTATTATCAGCAATAAGTCTGTCTTGCTTTCATATCATTTATGTGTTCAGTGGAGTAGCACTATTAGTTTTCTTCAAGAACTGCACTGGTGCAAGAGGCCTAGCTTTTGACCTGTATCCGTTTTTAACATGCCTTCCTGACTTCCTTAGAAGCTTAATCCTTTCT
TCAACAAAAAAGGTTGTGGATGGGGTGATCTGACACTTTTTCAAAAAATGCCAAAGCTTTAGAACTACACAGAACCATGAAACTTTTATAAGGTAACTGAAAGATAAGAAAATACAGTGATTCTTTACATCATTTAAAAAATAAGCATCAAGAACTCTATAAATCACTAATAAATAGAGGTTTAAGAATGGCTTGGGTAAACTGGTGGGTTAGTAAGTCCATAATAAGTTATGCAGCTAGGCGGGGTGCAGTGGCTCACGCCTGTAATTCCAACACTTTGGGAGACCAAGGTGGGCAGATCACTTAAGATCAGGAGTTCAAGACCAGCTTGGCCAACACAGTGAAACCCCATCTCTACTAAAAAATACAAAACAAAAACTAGCTGGACATGGTGGCACGCACCTGTAATTCCAGCTATTTGGGAGGCTAAGGCAGGAGAATGGCTTGAACCCAGGAGGTAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGAGCGACAGAGAGACACTCTGTCTCAAAAAAAAAAAAAAAATGTTATGCAGGTAAATCCTCCCATGGAGGTGGTTATTGCTCCTTCCACCCCCGAACACCCTCTGTCGCTTGGGTACCCTAAGATACCATGCTTTTATATAAAGCACTGTTCTTGTGAGAAATACGTGTAACCTGTGTTTTTTATGTTTAGAGATTTTATTCCCTCAAAGTTGCCCCCAAAGTTAAAGCCACAGCTGCGCCTGCAGGAGCACCGCCACAACCTCAGGACCTTGAGGTTAGTCCCACTAACTTGCTCGCTGGAAGCTATACATGCCTTACTCTCCTTGGTAATACGAAGACATTCATTATATCTCTACTTTATTTTAAATACAGTTTACCAAGTTACCAAATGGCTTGGTGATTGCTTCTTTGGAAAACTATTCTCCTGTATCAAGAATTGGTTTGTTCATTAAAGCAGGCAGTAGATATGAGGACTTCAGCAATTTAGGAACCACCCATTTGCTGCGTCTTACATCCAGTCTGGTGAGTATCTTCACTTCCTCAAGTGTTTGGAAATGCTGTGGTATCTTGGTCCTGTGAAAAAGAAAAACTAAGATCAATGTCTTTATATTTTGATTCCTTGACCTGCCATAACAAATTACCACGGACTGGGTAGCTTAAACCAAATAAGTTTATCCTGTTACAGTTCTAGAGGCTAGAAGTCCAAGTCAAGGTGTCTAAGCCAAGCCAAGATATCAGCAGGGCTGTGATCCCTCTAAAGGTTCTAGGAAGGCACAAATCCTCCCCTGCCTGTTCCTAGCTTCCAGCAGTTGCCCACAACCCTTCATGTTCCTTGACCTGCAACTGCATCACTGCAGTCTCTGCCTTTGTTGTCACATGGCCTTCCTTCTGTCTGTGTCCACATTTCCTCCTGATAAGGATACCAGTTACATTAGATTTAGTGCCCACTATAATTCAATATGATGTCATCTTAAGTACTTAAATCTGCAGAGACCTTATTACCAAATAAAGTAACATGCAAATATTCTGGCTGGACATAAATTTGGGGGGGAACACTGTTAAACCCAGTACTGTCCCCTAATGTAAAATGAGAAACCACAAGATATTTGCCACAGAGAAGCACTAAATTAGTATCCATATGAATGTTGATGTTAGAGCATAAGAAATCAGTAAACAAATTTTTAACAGGAAGTGCCGCAAATTGAAAGAAAATTAACTCTTTTTTTCCCATATACAAGTCTCTTTCAGAATAGACTAATGAATCCAGTAAGCTTGTATTTGACAGTGGAAATTTTACATGAATGTACTTAATGTAAAAATGTATACTTAAGCTTTTTGTTGAGCCTTGTTTTATAATTCTTAACTAAAAAGGATGCAGGAATTTAGTAAAATTCTTTTTAAATCTGCTCACAACAGATTTTGATATAGTGTGATGTTTGGCAAACTTGGCATTGAAAAGCTACAAAGATAATCATTCTTTCTTTTTCAAGACGACAAAAGGAGCTTCATCTTTCAAGATAACCCGTGGAATTGAAGCAGTTGGTGACAAATTAAGGTTTGTTAAATAAGTAATAGAAAATAGTGAAAATGCCAGAAAATATTCAATTTTAAGGGAACTTTTCTCTGTTATCAAGGAGGTTGAGGATTTCTTAAGCAACATAAGAAGGAAAAGACTGATGAATTTGAGTATATCAAACTGTAAAACATCTTTATGTCTTAAAGTAAAAATTTAAGTAACTGTCTGGGAGTAGATATCTGCAATATATAGGCATACCTCAGAGATGTTGCAGGTTCTGTTCCAGACCACCACAATGAAGGGAATATTGCAGCAAAGCAAGTCATAGGAATTTTGTGGTTTCCCAGTGCATATAAAAGTTATGTTTACACTATACTGTGGTCTACTAAGTGTACAATGACATTTTGTCTTGGAAAAAAAGTACATAACCTTAATTTTAAAATATTTTATTGCTTTAAAAATGTTAACAGTTATCTGAATCTTCAGCAAGTCATAATCTTTGCTGGTGGAGGGTCTTGCCTCCACGTTAATGGCTGATGACTGATCAAGGTGGTGGTTGCTGAAGGTGGTGGTGACTGATAATTTCTTAAAATCAGACAACAGTGAAGTTTGCTGCATTGATTGACTCTTCCTTTTGTGAAAGACTTCTCTGTAGCATGAGATGTTGTTTTTAGCCGTTTACCCACAGAACTTCTTTCAAAATTAGTCAGTCATCTCAAACCTTACCACTTTTTTATCAACCAAGATTATGTAATATTCTTTTTTATCATTTCGACAGTGTTCACAGCATCTTCAACCAGGAGCAGATTCTATCTCAAGAAACCACTTTGTTTGCTCATCCATAAGAAGCATCTCCTCATCTGTTCAAGCTTTATCATAAGATTGCAGCCATTCAGTCACATCTTCAGGCCCCACTTCTAGTTCTCTTGCTACTCCCACCATAGTTGCAGTTTCTTCCCCCTCTGAAGTCTTGCCTCTCAGAGTCATCCATAAGGGTTGGAATTGGCTTCTTCCAAACTCACGTTAATGTTGATACTTTGACATCCTCCCATGAGTCACAAATGTTCTTAATGGTGTCTAGAATGGTGAATTCTTTCCAGAAAGTTTTTTAATTTACTTTGCCCAGATCCATCAGCGTCTTCACTATCTGTGGTAGCTGTAGCCTTACAAAATGTATTTCTTAAATAATAAGACTTGAAAATAAAAATTACTCCTTGATCCATGGGGTGCAGAAGGGATGTTCTATTAGCAGGCATGAAAACAGTGTCAATCTCCTTGTACATCTGCATCAGAGCTCTTGGCATTGTTGCAGTAATAATTTGAAAGGAATCTTTTTTCTGAGCAATGGGCTTAAAATATTCAGTCAACCATGCTATAAACAGATGTACTATCATCCAGGCTTTTTTGTTCATTTACAGAGCATAGGCAGAGTAGATTTAGCATAATTCCTAAGGGCTCTAGGATTTTGAGAATGGTAAATGACCTCATCCTAAAGTCACCAGCTGCATTAGTCCCCAACAAGAGTCAGCTTGTCGTTTGAAGCTTTGACGCCAGGCATTGACTTCTCTAGCTACGAATGTCCTGGACGGCATCTTCCAATGTAAGGCTGTTTTGTCAGCATTGAAAATCTGTGGTTTAGTGTAGCCACCTTCATCGATGATCTTATGTAGATCTTCTGGATAACGTGCTGCAGCTTCTATATTAGCATTTGCTGCTTCACTGTGTACTATTATATTAAGAAGATGGCTTCTTTCCTTAAAGCTCATGAACTAACCACGGCTAGCTTCAGACTTTTCTTCTGCATCTCACCTCTCTCAGCCTTCATATAATTGAAGAGAGTTAGGGCATTGCTCTGGATTAAGCTTTGACTTAAGGGAATACAGTTTGATCTAATCCAGACCAGTAAAACTCTGTATTATCAGCAATAAGTCTGTCTTGCTTTCATATCATTTATGTGTTCAGTGGAGTAGCACTATTAGTTTTCTTCAAGAACTGCACTGGTGCAAGAGGCCTAGCTTTTGACCTGTATCCGTTTTTAACATGCCTTCCTGACTTCCTTAGAAGCTTAATCCTTTCT
Task1_train_22469
This genomic variant is located on Chromosome 16, within the PDZD9, UQCRC2 (PDZ domain containing 9| ubiquinol-cytochrome c reductase core protein 2) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Mitochondrial complex III deficiency nuclear type 5
CATGTTTGATGGTAAGTAAATTGTTTGTAAGATCCTAGAAGTTTTTCCTGTTTCCTTCCCAATGTTTTGTTTTTGTTTGTTTGTTTGTTTGTTTTTGAGACAGGGTGTTGCTTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCACTGCAGCCTGAACCTTCTGGACTCAGGTGATCCTCCTACCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACACACCACCGCACCCTGCTAATTTTTATTTTTATTTTTTTATAGAGATGAGGTCTCACTCTATTGCCCAGGCTGGTCTCGAACTCCTGGGCTGAAGTGATCCTCCCACCTCAGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCTGACCCCTAGTGATTTTTAAGAGTTGTTTTGCTTACCCCAAATCCTACACCAGTTTATTGCTGCTGCTATTATTGCTTACTATTGTATTGCTATTATTGTTTAGCCATCTCCTCTTTATTGAGTCTTTCCAAAGTAAGTAACTTAATTTTTTTAATAGGAATCTTTTTTGCATTCATATTTTATGTTTATATAATGTCTAATTATATAATCTTGACAAGTACAACTGGTAATACAAGTCTGTAAGCAAGCGCCGCTGACTCTTGGGAGTCATACAACTTCTGGTGGGAGCAGAAATGTGCAGGAAGAGCAGAAATAGCTCAACTCAGTGGTTCAGCATGGGACAGGCTCCCCTCCACATGCAGGCCTGGGGACTGATGTTATTTCATGATGATGCTTGGTGTCACAGAGGAGCATTATCTTTGTTGCTCAGGATTTCTACTGAAGAAATAGATAGAATAGTACAATTTTAGAAAAGATGACCTATGTGTCCAGAGTGGCTTCTTCCCCACTGGCGGCAGTGAGGCACCAGCCTGCATCTATTCTGCCTGAACAGTTACTGTGTAGTCTCCTGGCTGGTGTCAGCCTCCAGGTTTACGTCTTGAGTCCATCTCCCACACGGCCATTACAGTGATCCTTCTGACGTGAAAGTAAGCCTTCTTATTATCTATGGGATAAAGTCCAAACAGCATATACGTATATGGCCTTGCGTGATCTTACCCCAGCCCACTTCTCTTACTTTATGCTCTACCCTCTTCTCCTTCCAGCTGCAATTCCCATTTGAATCAAATTATTGTTATACTTTATGCCTTTGTTTTGTCTGCTTCCTGTGCCTAAAATGCTGTTCCCAAATGATTTCCCCTGGGAAACACCAGCTCATTCTGTAAGATGGATCCCACATATTACTTGTATTAATTGTTTTCCAATTCCCACTGCCCTTGCCTTGTACCTCTACTGCACTTTTGACACACTGCCGACATTGCACCCATAATACTTTATTTCACAGTTTTTCCTCTTAAAATTTGAGGGCAGGCATTGTATGTTCCACATCTCTGTATTTCTAGCACCTAGCACAGTGCCTCGCATAGGCAAGTTGCCAGGTAATGAGCAACTGAAGGAAATACTGCAGGCAAAAAGGCATTGAAGCAAGAAAGCAGGGAAAGCACCAAGCACCACAGAGGAGTAAGTCCCAGTGGAAGCTCCCATTGGTCCCCTGAAAGCTACCTGACAATCTCCTTATTACCTAGAGAGGAAACCTAGGAGTAAGTAAAATTCAGATTAAATGACTTGTCCAAGGTCACATGGCAAGATGGCGGCAGAACCATAACTAGATGGGGACTTCCCAAAACCCAGGCCAGTATACCTTCCAAGTGATACCAGCTAGGTTAAAGTTAGAAAAGTGGTTTAGGTGGACTCCAGTATATAGAAGCTGCTGCCATGTAATCTTTTTTATTTTTTTCTCAGCACATTCTACTGGCAGAAACTGGCAGTTACTAGAGGTTAAATAATAATAAATTTTAAGTCCTCTTAACATATGAATGCCAGAAGATGACCAAATTTGTATAGGCTTGTTGCTTTCTAGGTTTTAAAAATGTTGTCTTTACTGAAAGTGCATTTCCCTAAATGCTTCTTCACTTATCTCACAGATGTCATTGAAAATTTGCATGCAGCAGCTTACCGGAATGCCTTGGCTAATCCCTTGTATTGTCCTGACTATAGGATTGGAAAAGTGACATCAGAGGAGGTACCAATAAAACATATTTTGAAATGTGCTTGTTTTTCACATTAAATTGAACATCTCCCATTTCAGGTTTGTTTGTTAATTTTTCCTTTTATCTTCTAACTTTAAGAAATTCAGCGTGCTAGCTTTTTCATCCACCTGCTTTTTAACTAAAATTTTATCTGAACAATTTTTGTGTCTCCTTTAAGAAATGTTTTCATGACTAAAGGGACATGATCATTACAGAAAAATTAAAAAGTAAAATCAAACAAAATGAAGGGAAAGAAAACATCTCACATACCTAAAGGCACTCAGTGTTAATACCTGGTATATTTTCTTCTAAACCGTTTTCTGTGTGTATGTATCTTTTTTGTTTGTTTGTTTTAAATACGGGGTCTTGCTGTGTTGCCTAGGCTGGTCTTGAACTCTTAAGCTCAAGCAGTCCTTCTGCCTATGCCTCTCAAAGTGCTGGGATTACAGGCATGAGCCATTGCACCCAGCCTGTGTATCTTTTTTAAACAGTATTTAAATGTTTAAGTATCATAATAGGGGCTGGGCCCAGTGGCTCATGCGTGTAATCTCAGCACTTTGGGAGGCCAAGACAGAGGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTGGGCAACATAGCAAGACCCTGTCTCTACAAAAAAAAAATATATATATATGTGTGTGTGTATACATATATATAAAATAGGTCCTTTGACTAAAACTCTTTGGTCTCTCTGAATTTGTAAATAAGACTTGAGCCCACTTCCTTAGCTCCTGTTCCATCCTCGCTCACTCATTCACGTTCTTCAGCACACCAGCCTCCGTTTGCTGGCTATAGGGGTTTGTCACATGCCACAGCCATATGTGCATCTTAGAACTTTGTTTCCAAAACATGAAACATTGAATGCTAAATCTACAAGTGTAGATATGTGCGTATAATCTTAATTTCCTATTCCTACCACCCAGACCCAAAAACAAATTTTATCAAAAGACATTAAGAGAAAAATTTGTAATTATCAACACCTTCAAAGTATATCTGACTCAAAAATTCAAGGTTTTTATTCTCGTTTTATTCTTAGTTAGCTGTTACAGAAAACTAAACTGTATCCCTTGCTCTTTTTGACTTATCAATTAACAGTTTGATGCCTTTCATTCATATGGCACTTTTATTTAGAAATTTTAACTTACATCATCCAACTTGAACAGGCAGCCGTTTTCATAAGACTGGACTCTAATGAGTTTTGAAATTTTTCAGAAATCAAATTCACCCTCATGAAGATGTGTCATTAAGTTAGCTAAAACTTAGCAAAAGTTTATCTACAAGGATGGCTATTGTAATACTAGTTTATAATTGTGAAAAATTAGAAACAAGTTAATATCCAGCATTAGGGAACTAGTTAAATAACTTATAGAATGGAACAGTATTCAACCATTCAAAAATATTAGTTGATACATAAAACTCCACAGCATGTTGTCACATAAAGCAATTTATGGATTAGGACATACCAAAAGGTCCCTTTTTTTTAATAAAAGGTATGTATGTATGCATTATAGACAAATATCAAGATGTTAACTGTGATAACTTGGTTATCTCAAAGTTAATAGTATTTTTTAAATGTGTCCCTAGGCTAAAGGAAACTCTAAAGAAATTGGCGCTAGAATACTTGGAGCAATGGCAGCATCAATAGAAAAACATCAATAGAAAAAGAGTATGACTTTCCAAGGTTACTCCATAGGTACAGACACCATTCATTTTAGGGCACGGATTATGATAAATTGATTAAAAGTTCAGTTTCATTACTTTAGCCCAGTGATTCTCAAAACGTTATCACTTTCCTTCCTGAGGAGCCTTTCTAGCCATTTTTTTCTAAACCTCTTACTTTTAATACCACAGATAGAGTTTATGTGCTGTATATTTGTACTTTTTACATAGAAGTCGTAAGTTTTTTTTTTTTCTTAGTTACCCCAAACCAATTTTCACCCATCTGGAAAG
CATGTTTGATGGTAAGTAAATTGTTTGTAAGATCCTAGAAGTTTTTCCTGTTTCCTTCCCAATGTTTTGTTTTTGTTTGTTTGTTTGTTTGTTTTTGAGACAGGGTGTTGCTTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCACTGCAGCCTGAACCTTCTGGACTCAGGTGATCCTCCTACCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACACACCACCGCACCCTGCTAATTTTTATTTTTATTTTTTTATAGAGATGAGGTCTCACTCTATTGCCCAGGCTGGTCTCGAACTCCTGGGCTGAAGTGATCCTCCCACCTCAGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCTGACCCCTAGTGATTTTTAAGAGTTGTTTTGCTTACCCCAAATCCTACACCAGTTTATTGCTGCTGCTATTATTGCTTACTATTGTATTGCTATTATTGTTTAGCCATCTCCTCTTTATTGAGTCTTTCCAAAGTAAGTAACTTAATTTTTTTAATAGGAATCTTTTTTGCATTCATATTTTATGTTTATATAATGTCTAATTATATAATCTTGACAAGTACAACTGGTAATACAAGTCTGTAAGCAAGCGCCGCTGACTCTTGGGAGTCATACAACTTCTGGTGGGAGCAGAAATGTGCAGGAAGAGCAGAAATAGCTCAACTCAGTGGTTCAGCATGGGACAGGCTCCCCTCCACATGCAGGCCTGGGGACTGATGTTATTTCATGATGATGCTTGGTGTCACAGAGGAGCATTATCTTTGTTGCTCAGGATTTCTACTGAAGAAATAGATAGAATAGTACAATTTTAGAAAAGATGACCTATGTGTCCAGAGTGGCTTCTTCCCCACTGGCGGCAGTGAGGCACCAGCCTGCATCTATTCTGCCTGAACAGTTACTGTGTAGTCTCCTGGCTGGTGTCAGCCTCCAGGTTTACGTCTTGAGTCCATCTCCCACACGGCCATTACAGTGATCCTTCTGACGTGAAAGTAAGCCTTCTTATTATCTATGGGATAAAGTCCAAACAGCATATACGTATATGGCCTTGCGTGATCTTACCCCAGCCCACTTCTCTTACTTTATGCTCTACCCTCTTCTCCTTCCAGCTGCAATTCCCATTTGAATCAAATTATTGTTATACTTTATGCCTTTGTTTTGTCTGCTTCCTGTGCCTAAAATGCTGTTCCCAAATGATTTCCCCTGGGAAACACCAGCTCATTCTGTAAGATGGATCCCACATATTACTTGTATTAATTGTTTTCCAATTCCCACTGCCCTTGCCTTGTACCTCTACTGCACTTTTGACACACTGCCGACATTGCACCCATAATACTTTATTTCACAGTTTTTCCTCTTAAAATTTGAGGGCAGGCATTGTATGTTCCACATCTCTGTATTTCTAGCACCTAGCACAGTGCCTCGCATAGGCAAGTTGCCAGGTAATGAGCAACTGAAGGAAATACTGCAGGCAAAAAGGCATTGAAGCAAGAAAGCAGGGAAAGCACCAAGCACCACAGAGGAGTAAGTCCCAGTGGAAGCTCCCATTGGTCCCCTGAAAGCTACCTGACAATCTCCTTATTACCTAGAGAGGAAACCTAGGAGTAAGTAAAATTCAGATTAAATGACTTGTCCAAGGTCACATGGCAAGATGGCGGCAGAACCATAACTAGATGGGGACTTCCCAAAACCCAGGCCAGTATACCTTCCAAGTGATACCAGCTAGGTTAAAGTTAGAAAAGTGGTTTAGGTGGACTCCAGTATATAGAAGCTGCTGCCATGTAATCTTTTTTATTTTTTTCTCAGCACATTCTACTGGCAGAAACTGGCAGTTACTAGAGGTTAAATAATAATAAATTTTAAGTCCTCTTAACATATGAATGCCAGAAGATGACCAAATTTGTATAGGCTTGTTGCTTTCTAGGTTTTAAAAATGTTGTCTTTACTGAAAGTGCATTTCCCTAAATGCTTCTTCACTTATCTCACAGATGTCATTGAAAATTTGCATGCAGCAGCTTACTGGAATGCCTTGGCTAATCCCTTGTATTGTCCTGACTATAGGATTGGAAAAGTGACATCAGAGGAGGTACCAATAAAACATATTTTGAAATGTGCTTGTTTTTCACATTAAATTGAACATCTCCCATTTCAGGTTTGTTTGTTAATTTTTCCTTTTATCTTCTAACTTTAAGAAATTCAGCGTGCTAGCTTTTTCATCCACCTGCTTTTTAACTAAAATTTTATCTGAACAATTTTTGTGTCTCCTTTAAGAAATGTTTTCATGACTAAAGGGACATGATCATTACAGAAAAATTAAAAAGTAAAATCAAACAAAATGAAGGGAAAGAAAACATCTCACATACCTAAAGGCACTCAGTGTTAATACCTGGTATATTTTCTTCTAAACCGTTTTCTGTGTGTATGTATCTTTTTTGTTTGTTTGTTTTAAATACGGGGTCTTGCTGTGTTGCCTAGGCTGGTCTTGAACTCTTAAGCTCAAGCAGTCCTTCTGCCTATGCCTCTCAAAGTGCTGGGATTACAGGCATGAGCCATTGCACCCAGCCTGTGTATCTTTTTTAAACAGTATTTAAATGTTTAAGTATCATAATAGGGGCTGGGCCCAGTGGCTCATGCGTGTAATCTCAGCACTTTGGGAGGCCAAGACAGAGGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTGGGCAACATAGCAAGACCCTGTCTCTACAAAAAAAAAATATATATATATGTGTGTGTGTATACATATATATAAAATAGGTCCTTTGACTAAAACTCTTTGGTCTCTCTGAATTTGTAAATAAGACTTGAGCCCACTTCCTTAGCTCCTGTTCCATCCTCGCTCACTCATTCACGTTCTTCAGCACACCAGCCTCCGTTTGCTGGCTATAGGGGTTTGTCACATGCCACAGCCATATGTGCATCTTAGAACTTTGTTTCCAAAACATGAAACATTGAATGCTAAATCTACAAGTGTAGATATGTGCGTATAATCTTAATTTCCTATTCCTACCACCCAGACCCAAAAACAAATTTTATCAAAAGACATTAAGAGAAAAATTTGTAATTATCAACACCTTCAAAGTATATCTGACTCAAAAATTCAAGGTTTTTATTCTCGTTTTATTCTTAGTTAGCTGTTACAGAAAACTAAACTGTATCCCTTGCTCTTTTTGACTTATCAATTAACAGTTTGATGCCTTTCATTCATATGGCACTTTTATTTAGAAATTTTAACTTACATCATCCAACTTGAACAGGCAGCCGTTTTCATAAGACTGGACTCTAATGAGTTTTGAAATTTTTCAGAAATCAAATTCACCCTCATGAAGATGTGTCATTAAGTTAGCTAAAACTTAGCAAAAGTTTATCTACAAGGATGGCTATTGTAATACTAGTTTATAATTGTGAAAAATTAGAAACAAGTTAATATCCAGCATTAGGGAACTAGTTAAATAACTTATAGAATGGAACAGTATTCAACCATTCAAAAATATTAGTTGATACATAAAACTCCACAGCATGTTGTCACATAAAGCAATTTATGGATTAGGACATACCAAAAGGTCCCTTTTTTTTAATAAAAGGTATGTATGTATGCATTATAGACAAATATCAAGATGTTAACTGTGATAACTTGGTTATCTCAAAGTTAATAGTATTTTTTAAATGTGTCCCTAGGCTAAAGGAAACTCTAAAGAAATTGGCGCTAGAATACTTGGAGCAATGGCAGCATCAATAGAAAAACATCAATAGAAAAAGAGTATGACTTTCCAAGGTTACTCCATAGGTACAGACACCATTCATTTTAGGGCACGGATTATGATAAATTGATTAAAAGTTCAGTTTCATTACTTTAGCCCAGTGATTCTCAAAACGTTATCACTTTCCTTCCTGAGGAGCCTTTCTAGCCATTTTTTTCTAAACCTCTTACTTTTAATACCACAGATAGAGTTTATGTGCTGTATATTTGTACTTTTTACATAGAAGTCGTAAGTTTTTTTTTTTTCTTAGTTACCCCAAACCAATTTTCACCCATCTGGAAAG
Task1_train_22470
This sequence variant lies in PDZD9, UQCRC2 (PDZ domain containing 9| ubiquinol-cytochrome c reductase core protein 2) on Chromosome 16. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Mitochondrial complex III deficiency nuclear type 5
GTTTGATGCCTTTCATTCATATGGCACTTTTATTTAGAAATTTTAACTTACATCATCCAACTTGAACAGGCAGCCGTTTTCATAAGACTGGACTCTAATGAGTTTTGAAATTTTTCAGAAATCAAATTCACCCTCATGAAGATGTGTCATTAAGTTAGCTAAAACTTAGCAAAAGTTTATCTACAAGGATGGCTATTGTAATACTAGTTTATAATTGTGAAAAATTAGAAACAAGTTAATATCCAGCATTAGGGAACTAGTTAAATAACTTATAGAATGGAACAGTATTCAACCATTCAAAAATATTAGTTGATACATAAAACTCCACAGCATGTTGTCACATAAAGCAATTTATGGATTAGGACATACCAAAAGGTCCCTTTTTTTTAATAAAAGGTATGTATGTATGCATTATAGACAAATATCAAGATGTTAACTGTGATAACTTGGTTATCTCAAAGTTAATAGTATTTTTTAAATGTGTCCCTAGGCTAAAGGAAACTCTAAAGAAATTGGCGCTAGAATACTTGGAGCAATGGCAGCATCAATAGAAAAACATCAATAGAAAAAGAGTATGACTTTCCAAGGTTACTCCATAGGTACAGACACCATTCATTTTAGGGCACGGATTATGATAAATTGATTAAAAGTTCAGTTTCATTACTTTAGCCCAGTGATTCTCAAAACGTTATCACTTTCCTTCCTGAGGAGCCTTTCTAGCCATTTTTTTCTAAACCTCTTACTTTTAATACCACAGATAGAGTTTATGTGCTGTATATTTGTACTTTTTACATAGAAGTCGTAAGTTTTTTTTTTTTCTTAGTTACCCCAAACCAATTTTCACCCATCTGGAAAGGATAGCATTTCTGTTGAAAGTACATGTTTTAGCCCTACTTTTGTATATTAAGCCTAAGGTGGTAATATAAACCAGTGATAACCAAGTCTCACCAATCTTCAGATCGCCTGAGTGGTTGATTGGATGGATGGGTAGTTGGTCGGTTTTAAATAAGGATTCTAGGATTCCACATTTAATATTTTATATCAGTCTGTAGGGTAAGTCCCAAGAATGGGGGACAGTGACCGTTTTTGTTTTTCAAGCTGAGTAATTGTGATCTTACAGTTTCGACACCCTGGTATAGACAATGACTTCATGGTCAGAAAAGCTTTATAGAGATTGGCTTCAAAGATGGACGAGAAGGGTGTTGTGGTAAAACTCTGTTAGCCCTGTTATAGAATGTTAATAGTGCTTCATTACTACTTATATAAACACAAAAGAAACCTGACATACTACGTAAGCTACATTATAATAAAAATCATAGTCCACGTTTTCAAGTTTAGGCCAGTGTATGCTCTAATTTCTTTTTATTCCTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTGTGTCGCCCAGGCCAGAGTGCAATGACACGATCTCAGCTCACTGCAACCTCTGCCTCCTGGATTCAAACAATTCTCGTGCCTCAGCCACCCATGTAGCTGGGATTACAGGCGTGCACCACCATGCCTGGCTAATTTTTGCATTTTTAGTAGAGTCAGGATTTCGCTGTGTTGCCCAGGCTGGTCTCAAACTCGTGGCCTCAAATGATCCGCCAGCCTTGGCCTCCCAGAGTGCTGGGATTACAGACATGAGCTACTGCACCCAGCCTCTTTTTATTCCTTTTATAAATAACAGCTTTGTTGAGATGTAATTCACCATACTATACAACCTATTTAAAGTGTACACAATTCAGTGGTTTTCATTATATTCACAGAGTTGTGCAACCATGACCACAATTAGGTTCTAGTTCTTTTAAGCAATAGTTTTTATAATAAAATCCCAGGGTAATTCACCTCAGTTAGTACCTTGTAGTTCATTACAGCAACTTATAAGGCCTTATAAGTATTTATTTTCTTCCAAACTGTACTTTTATGTTTTTACAGCTTTTTATATTTATGCTAATATAACCTAATAAGTGTTTTTAACTTCCTCAGTTACATTACTTCGTTCAGAACCATTTCACAAGTGCAAGAATGGCTTTGATTGGACTTGGTAAGTTTAGAGTATTGCCTGCCTGTCAGTTTGCTTCCTTAAGAGCAGTTCCTTAAACTGTAATTACGTGAACATAGGATTGAACAAAATTTGAAAACTTCGGCCTTCTATTTATGTCAGACAGGCAATATATCATAGGATTTTAATTGCTAGTCATTTGTTTTGGAAAGCAGAATCCAACATTTAAATTTGTAAACCACTGGCTTTAAATTCTTTACAGTATTTGTAAAACCTGTGACAAAGGTGAATTTCTCAAAGCAAAGAGCTTTTACAAACTTTTTTAAAAGGAAGTACAGCTTACTAGAAAAACAGGCAAAGGGCATGAACAGACAGTTCATGGGAGAAATATGTTTGTATATGTGTAGCCAACTATCTTTGTTTTAAATGATCAGCCTCACTAATAATTAAGAAAATTTTAATCTGTGATGTTGGCAAAATTAAAAGATGGACTCTGCCCAGAATTAACCAGGGTATGGAGAAATAGGCACTCTCACAAATTGTTAGTAGGAATATAAACTAGTACAACATTTTGGGAGATCTTTTTGAACATATCTGTTAAAATTCTAGGCTGGGCATGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTAGCCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTAGTCGGGCATGGTGACACATGCCTGTAATCCCAGCTATCGGGGGGCTGAGGAGGAGAATCGCTTGAACCCAGGAGGCAGTGATTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCAAGGGCGACAGAGTGAGACTCTGTCTCAAAAAAATACAATTCCAAATGTTTACACTCATAGACCCAGTGACTTTTAAGAATTTGTCTTACAGAAACATTAGGTCAAGTTTACAAAGTAGTTGCATGAGAATATCATTTGTAATATTTTTTGTTTTGTTTTGCAAATTACAGCTTAAGATATAATTTACATGCTATAAAATTCACCCTTTTGAAGTGAATAGTTCTGTGGTTTTTAACAGATTCAACTATTACCACTACCTAATTTCAGGGTGTGTTCATCATCCCCCCAAAAGCCCCATACCCATTAGCAGTCACTCCCCATTCTCATCTTCCCCCTGCCTGTGGCATCCACTAATCTACTTTGTTTTTGTTTTTTTTTTTAAAGAGATGGAGGTCTCATTCTGTTGCCCAAGCTGGAGCACAGTGGCACAATCATAGCTCACTGCCTTGAACTCCTAGGCTCAGGTGATCCTCCCACCTCAGCCTCCTAAGTAGCAATAATCTACTTTGTCTCTATAGATTTGACTATTCTGGACATTTCCTATAAATGGAGTCATACGATATGTGGCCTTTTGTAACTGGCTTTTCTTACTTAGCATAATGTTTTCAAGGTCCGTCCATATTGTAGCATGTGTCAATTCAATGTCTTATTCCCTTTTATGGCTCAAGAATACTCCATTACCACATTTTGTTTATTCATTGATTGGCATTTGGGTTGTTTCTACCTTTTGGCTGTCGTAAATATAAACATTCACGTGTACATTTTTCTTAGGAAACCTGTTTTTAGTTCTTTTGGTTATGTCTAAGAACAGAATTGCCAGGACATATGGTAACTCTGTTTAACCATTTGGGGAACTGCCAGACTGTTTTCCAAAGTAGCTGCACCATTTTACATTCCCACCAGCAATGCACAAAGGTTTTGATTTCTCCACATCCTCACCAACACTTATCGTCTGTCTTTCTGATTATGAACAACCTACTGGGTGGGAAGTGGTCATTGTAGTTTTGATTTGTATTTCCCTAATGACAAATGACATTGAACATATTTTCATGTGCTTTTTGTCCATTTGTATAACTTTTTTTGTTTGTTTGTTTTTTTGAGACAGAGGCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCACTTCCCAGGTTCAAGCAATTCTCCGGCCTCAGCCTCCCGAGTAGCTGGGATTACA
GTTTGATGCCTTTCATTCATATGGCACTTTTATTTAGAAATTTTAACTTACATCATCCAACTTGAACAGGCAGCCGTTTTCATAAGACTGGACTCTAATGAGTTTTGAAATTTTTCAGAAATCAAATTCACCCTCATGAAGATGTGTCATTAAGTTAGCTAAAACTTAGCAAAAGTTTATCTACAAGGATGGCTATTGTAATACTAGTTTATAATTGTGAAAAATTAGAAACAAGTTAATATCCAGCATTAGGGAACTAGTTAAATAACTTATAGAATGGAACAGTATTCAACCATTCAAAAATATTAGTTGATACATAAAACTCCACAGCATGTTGTCACATAAAGCAATTTATGGATTAGGACATACCAAAAGGTCCCTTTTTTTTAATAAAAGGTATGTATGTATGCATTATAGACAAATATCAAGATGTTAACTGTGATAACTTGGTTATCTCAAAGTTAATAGTATTTTTTAAATGTGTCCCTAGGCTAAAGGAAACTCTAAAGAAATTGGCGCTAGAATACTTGGAGCAATGGCAGCATCAATAGAAAAACATCAATAGAAAAAGAGTATGACTTTCCAAGGTTACTCCATAGGTACAGACACCATTCATTTTAGGGCACGGATTATGATAAATTGATTAAAAGTTCAGTTTCATTACTTTAGCCCAGTGATTCTCAAAACGTTATCACTTTCCTTCCTGAGGAGCCTTTCTAGCCATTTTTTTCTAAACCTCTTACTTTTAATACCACAGATAGAGTTTATGTGCTGTATATTTGTACTTTTTACATAGAAGTCGTAAGTTTTTTTTTTTTCTTAGTTACCCCAAACCAATTTTCACCCATCTGGAAAGGATAGCATTTCTGTTGAAAGTACATGTTTTAGCCCTACTTTTGTATATTAAGCCTAAGGTGGTAATATAAACCAGTGATAACCAAGTCTCACCAATCTTCAGATCGCCTGAGTGGTTGATTGGATGGATGGGTAGTTGGTCGGTTTTAAATAAGGATTCTAGGATTCCACATTTAATATTTTATATCAGTCTGTAGGGTAAGTCCCAAGAATGGGGGACAGTGACCGTTTTTGTTTTTCAAGCTGAGTAATTGTGATCTTACAGTTTCGACACCCTGGTATAGACAATGACTTCATGGTCAGAAAAGCTTTATAGAGATTGGCTTCAAAGATGGACGAGAAGGGTGTTGTGGTAAAACTCTGTTAGCCCTGTTATAGAATGTTAATAGTGCTTCATTACTACTTATATAAACACAAAAGAAACCTGACATACTACGTAAGCTACATTATAATAAAAATCATAGTCCACGTTTTCAAGTTTAGGCCAGTGTATGCTCTAATTTCTTTTTATTCCTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTGTGTCGCCCAGGCCAGAGTGCAATGACACGATCTCAGCTCACTGCAACCTCTGCCTCCTGGATTCAAACAATTCTCGTGCCTCAGCCACCCATGTAGCTGGGATTACAGGCGTGCACCACCATGCCTGGCTAATTTTTGCATTTTTAGTAGAGTCAGGATTTCGCTGTGTTGCCCAGGCTGGTCTCAAACTCGTGGCCTCAAATGATCCGCCAGCCTTGGCCTCCCAGAGTGCTGGGATTACAGACATGAGCTACTGCACCCAGCCTCTTTTTATTCCTTTTATAAATAACAGCTTTGTTGAGATGTAATTCACCATACTATACAACCTATTTAAAGTGTACACAATTCAGTGGTTTTCATTATATTCACAGAGTTGTGCAACCATGACCACAATTAGGTTCTAGTTCTTTTAAGCAATAGTTTTTATAATAAAATCCCAGGGTAATTCACCTCAGTTAGTACCTTGTAGTTCATTACAGCAACTTATAAGGCCTTATAAGTATTTATTTTCTTCCAAACTGTACTTTTATGTTTTTACAGCTTTTTATATTTATGCTAATATAACCTAATAAGTGTTTTTAACTTCCTCAGTTACATTACTTCGTTCAGAACCATTTCACAAGTGCAAGAATGGCTTTGATTGCACTTGGTAAGTTTAGAGTATTGCCTGCCTGTCAGTTTGCTTCCTTAAGAGCAGTTCCTTAAACTGTAATTACGTGAACATAGGATTGAACAAAATTTGAAAACTTCGGCCTTCTATTTATGTCAGACAGGCAATATATCATAGGATTTTAATTGCTAGTCATTTGTTTTGGAAAGCAGAATCCAACATTTAAATTTGTAAACCACTGGCTTTAAATTCTTTACAGTATTTGTAAAACCTGTGACAAAGGTGAATTTCTCAAAGCAAAGAGCTTTTACAAACTTTTTTAAAAGGAAGTACAGCTTACTAGAAAAACAGGCAAAGGGCATGAACAGACAGTTCATGGGAGAAATATGTTTGTATATGTGTAGCCAACTATCTTTGTTTTAAATGATCAGCCTCACTAATAATTAAGAAAATTTTAATCTGTGATGTTGGCAAAATTAAAAGATGGACTCTGCCCAGAATTAACCAGGGTATGGAGAAATAGGCACTCTCACAAATTGTTAGTAGGAATATAAACTAGTACAACATTTTGGGAGATCTTTTTGAACATATCTGTTAAAATTCTAGGCTGGGCATGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTAGCCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTAGTCGGGCATGGTGACACATGCCTGTAATCCCAGCTATCGGGGGGCTGAGGAGGAGAATCGCTTGAACCCAGGAGGCAGTGATTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCAAGGGCGACAGAGTGAGACTCTGTCTCAAAAAAATACAATTCCAAATGTTTACACTCATAGACCCAGTGACTTTTAAGAATTTGTCTTACAGAAACATTAGGTCAAGTTTACAAAGTAGTTGCATGAGAATATCATTTGTAATATTTTTTGTTTTGTTTTGCAAATTACAGCTTAAGATATAATTTACATGCTATAAAATTCACCCTTTTGAAGTGAATAGTTCTGTGGTTTTTAACAGATTCAACTATTACCACTACCTAATTTCAGGGTGTGTTCATCATCCCCCCAAAAGCCCCATACCCATTAGCAGTCACTCCCCATTCTCATCTTCCCCCTGCCTGTGGCATCCACTAATCTACTTTGTTTTTGTTTTTTTTTTTAAAGAGATGGAGGTCTCATTCTGTTGCCCAAGCTGGAGCACAGTGGCACAATCATAGCTCACTGCCTTGAACTCCTAGGCTCAGGTGATCCTCCCACCTCAGCCTCCTAAGTAGCAATAATCTACTTTGTCTCTATAGATTTGACTATTCTGGACATTTCCTATAAATGGAGTCATACGATATGTGGCCTTTTGTAACTGGCTTTTCTTACTTAGCATAATGTTTTCAAGGTCCGTCCATATTGTAGCATGTGTCAATTCAATGTCTTATTCCCTTTTATGGCTCAAGAATACTCCATTACCACATTTTGTTTATTCATTGATTGGCATTTGGGTTGTTTCTACCTTTTGGCTGTCGTAAATATAAACATTCACGTGTACATTTTTCTTAGGAAACCTGTTTTTAGTTCTTTTGGTTATGTCTAAGAACAGAATTGCCAGGACATATGGTAACTCTGTTTAACCATTTGGGGAACTGCCAGACTGTTTTCCAAAGTAGCTGCACCATTTTACATTCCCACCAGCAATGCACAAAGGTTTTGATTTCTCCACATCCTCACCAACACTTATCGTCTGTCTTTCTGATTATGAACAACCTACTGGGTGGGAAGTGGTCATTGTAGTTTTGATTTGTATTTCCCTAATGACAAATGACATTGAACATATTTTCATGTGCTTTTTGTCCATTTGTATAACTTTTTTTGTTTGTTTGTTTTTTTGAGACAGAGGCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCACTTCCCAGGTTCAAGCAATTCTCCGGCCTCAGCCTCCCGAGTAGCTGGGATTACA
Task1_train_22471
This variant lies on Chromosome 16 and affects the gene SCNN1B (sodium channel epithelial 1 subunit beta). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Liddle syndrome 1
CACAGCCTGTCCTGGACCCAAGTCATTCTGCAAGTCAACTAGCTGAGACAAAAGATACAGGAAATGGCTTTCTTATCTGAAAACACGGGAAAATAACACCTGCCCTTGTGGGGTTATTTTGAGAATTAAATGAGATCACGAATACAGAAAGATTCAGCACAGGCCTGGCCCATAAAAGTCACTCAGTGAATGTTTGCTGTGGAGCATAAGGCTTCAAAGACAATACTGCATGGCAGGTGACGTTTTATGTGTGTGCATTATTTGATGTACTTACTCTCATTCCTTCCTGTTTTTATTTTTAATTTTTTACAAATTATTATTGTTTTTTTGATACAGAGTCTCACTCTGTTGCCCAGGCAGGAGTACAGTGGTGCAATCACAGCTCACTACAGCCTCAACCTCCCCAGGCTCAGGTGATCAATCCACATCAGCCTCCCAAGTAGCTGGGACTACAGACACTCACCACTACTCCTGGCTTTTTATTTTATTTTATTTTTTATTTTTTGTAGAGATAGGGTCTCAATTCGTTGGCCAGGCTGATCTCAAACTCCTGGGCTCAGTTGGGTGCAGTGGCTCACGCCTGTAATCGCAGCACTTTGGGAAGCCAAGGTGTGGGGATCACCCGAGGTCAAGAGTTCAAGAGCAGCCTGGCCAACATGATGAAACCCCATCTGCACTAAAAATACACAAATTAGCCGGGTGTGGTGGCGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTGAGATTCTCCTCAGCCTGGAGTGAGATCACACCACTGTACTCCAGCCTGAGCAACATAGTGAGACTCTGTCTCAAAAACAAACAAACAAACAAAACTCCTGGGCTCAAGTGATCCTCCCACTTTGGCCTCCCAAAGTGCTGGAATTACAGGCATAAGCCACCGCTCCCAACCTCCTCTTATTTTTAATAAATAAAAAAAGAACAACATAGAAACATCAAGAGATATTTTTTAAAGCTGCTTACTTTGGAGACTTGAGAACATGCACTTCGACTGAACAGAGTTTGATGAACTCCAGCACACCAGTCATCAGAAGAGGCAAGGAGGAATTCTCCCCTGAGCCTTCTGGTGGGCCCAGGAGTTCCTCGGCTTGTGTCTGAAGGCCCCTGCCTCAGTCTTCAATGAGCTTCTCCTCTGTATCTGTCTCTCTTCTGTGTCTTCTAAGGATGCTTGTCATTTGATTTCGGGCCCACCTGGATAATCCAAGATGACCTCATCTCGAGATCCTTAGCACATCTGCAAGGACCCTTTCTCCAAATAAGGTCACACTCATAGGTTCCGGGGCTGAGGACATGGATGTGCCTCTTTTGAGGTGTATACGAGACAGATGAAAACATCTGAGAAAGTTCTTTTTCATTTTTGTTGTTGTTGTTTGTTGTTGTTTTAGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCATAGCTCAAGCAGCCTCGAACTCCTGGGCTCAAGCGTTCCTCCCACCTCAGCCTCCCAAGTAACTGGGACTGCAGGCATGCACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGAGGGTCTCACCATGTTGCCCAACCTGGTCTCAAACTCCTGGCCTCAAGCGGTCCTCCCGCCTCAGCCTTCCAAAGTGCTAGGATTACAGGCGTGAGCCACCACGCCCGGCCAGAAAGTTCTTTTTCATAACTCATGGCCAAACCAGAGAGCCTGAGCCCCAACTCCAGAGAAACTCTCTTCCCCTGCTTTCCCAAGGGAGCCTGGGAATCTCCCCTCTGGTTTGGACCAGAGGATGGACAGAATGACCTGTTGCTCGCCTCTCCCTTTCGGAGCCCCTCCAAGGAGGAAATGAAAGGTGGACGGCAGACAGTCGGGGGAGGCATTGCCTGTGGTGGAACCTGCCCTGCAGCTGATGCTGTTTCTTTTAGGAACTTCACGTCCATCTTCTACCCTCACTATGGCAACTGTTACATCTTCAACTGGGGCATGACAGAGAAGGCACTTCCTTCGGCCAACCCTGGAACTGAATTCGGTGAGTTTTGGTTTATCGTGGGGCCAGAGCCATGAGGCTTTAACCACCCCCACAATGTGGGACTGAAAGACCATCAGCTGTTGCAGGGTGGGACTGAGGGGGGACCAAGGCATCAAGAGGAGTGGCTGCTACCGAGGCTCTACTGTGTGCCAGGGGAGGCCAGGCCAGGCGCTTCCTCAGCCATTCCCGCCCACAATGTTCAGAATCCGTGGGGTAGCAACTGGTGTTCCCATTTTACTGATGAGCAAAGTGAGGACTTGGAAGCAGCACAGCTTCGTGGTCAAGAGCTCAAGCTTCAGCCAGGCGTGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGAGGATTGTTCAAGCCCAAGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAACCCCATCTCTTAAAAAAAAAATACAAAAATTAGCGAGGCATGATGGCACGTACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAAGATCGCTTGAGCTGGGAAGGTCAAGGCAGCAGTGAGCCATGATCACACCACTGCAGCTCCACCATTTACTTGGGTGGTGTTCCTGAGCTCCAGAGCAACCTTCTCAAAGCCTTAGTTTCCCCAATCATAGATTAGTATATAGTAGCAGAGCAGAGCATTTAGTATAGTAAATCGTATCTACCGTGTGAGCCATGATGATGAGTAAATAGTATAAGCCTTGTGAGTCATTACGATGTAATGTGGTAAATCGTTTCACCTGCCTAGGAAGTAGGGAATGCTCCATATATGCTGAGTATTCTGAGCAGTTTTTAAACAACTTGTCCAGGATCATGCAGTTAATACATGGACCAAAAGACATTGCATGTTCTTACCTGTAAGTGGGAGCTAAATGATGTGCACACGTGGATATAGAGTGTGGAAGGAGAGACATCAGAGACTTAGAGGGTGGGAGGGTAGGAGGCAGGTGAGGGACAAGAAATTAATGAGTACAGTATATATGATTCCAGTGAAGGTTACACTAAAAGCCTAGACTTCACCACTGTATAATAATTCCATGTAACAAAACTGCGCTTGAACCCCTTACATTTATACAAATTAGAAAAAGAAAAGAAATACATAACAGTCTCTTAGTCTCTCTGCCTCTCTGGTGTACAGTTTGTTTGTTTGTTTTCTTGAGACAGGGTCTCACTCTGTCACCCAAACTGGAGTGCAGTGGCACGGTCATGGCTCACTGCAGCCTCAACCTCCTGGGCTCAGGTGATCCTCCCACCTCAGCCTCCTGAGGAGCTAGGATTGCAGGTGGCTAATTTTTTGTAGAGATAAGGTTTCATCCTGTTGCCCAGGTTGGTCTTGACCTCCTGGGCTCAAGCAATCTGCCCTCCTTGGCCTCTCAAAGTACTGGGATTACAGATGTGATCCACTGCGCCCAGCTGTACAGTTCTTAAAGAAAGACAGAGACACACAGAGAGAAGCTGAAGGAGTCCATGGAAGTGAGGAAGTGGGGCATGGTGGATGACGGATCCCCCTCCCTCGGGGCTCATGTGTTGCACTGACCCCTAGAGAGGGGCTGGTGGACTCAGGCTGGCTGTGGTTTTGCGGCTTGTGAGCCGGGCACAGGTGGGAGTGGATCCCTCCTCCCATCTCTAGGTTCTGACCTCTGCAACCACCAAGAGGCAGGCTCTCATTCAGCGACCATCGGGGCCGCTGGCCAAGAGGGCAGGTGAGCTGAGTGCCTTTCACTTAGCCCCCATGCTGCTGAGAGCACTGCCACAGAGGTGCCAGTCAACTTACTCCCAGAGGCAGATGGTTATAGTCAGGGAGCCAGCTGCTGTATCAGAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTG
CACAGCCTGTCCTGGACCCAAGTCATTCTGCAAGTCAACTAGCTGAGACAAAAGATACAGGAAATGGCTTTCTTATCTGAAAACACGGGAAAATAACACCTGCCCTTGTGGGGTTATTTTGAGAATTAAATGAGATCACGAATACAGAAAGATTCAGCACAGGCCTGGCCCATAAAAGTCACTCAGTGAATGTTTGCTGTGGAGCATAAGGCTTCAAAGACAATACTGCATGGCAGGTGACGTTTTATGTGTGTGCATTATTTGATGTACTTACTCTCATTCCTTCCTGTTTTTATTTTTAATTTTTTACAAATTATTATTGTTTTTTTGATACAGAGTCTCACTCTGTTGCCCAGGCAGGAGTACAGTGGTGCAATCACAGCTCACTACAGCCTCAACCTCCCCAGGCTCAGGTGATCAATCCACATCAGCCTCCCAAGTAGCTGGGACTACAGACACTCACCACTACTCCTGGCTTTTTATTTTATTTTATTTTTTATTTTTTGTAGAGATAGGGTCTCAATTCGTTGGCCAGGCTGATCTCAAACTCCTGGGCTCAGTTGGGTGCAGTGGCTCACGCCTGTAATCGCAGCACTTTGGGAAGCCAAGGTGTGGGGATCACCCGAGGTCAAGAGTTCAAGAGCAGCCTGGCCAACATGATGAAACCCCATCTGCACTAAAAATACACAAATTAGCCGGGTGTGGTGGCGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTGAGATTCTCCTCAGCCTGGAGTGAGATCACACCACTGTACTCCAGCCTGAGCAACATAGTGAGACTCTGTCTCAAAAACAAACAAACAAACAAAACTCCTGGGCTCAAGTGATCCTCCCACTTTGGCCTCCCAAAGTGCTGGAATTACAGGCATAAGCCACCGCTCCCAACCTCCTCTTATTTTTAATAAATAAAAAAAGAACAACATAGAAACATCAAGAGATATTTTTTAAAGCTGCTTACTTTGGAGACTTGAGAACATGCACTTCGACTGAACAGAGTTTGATGAACTCCAGCACACCAGTCATCAGAAGAGGCAAGGAGGAATTCTCCCCTGAGCCTTCTGGTGGGCCCAGGAGTTCCTCGGCTTGTGTCTGAAGGCCCCTGCCTCAGTCTTCAATGAGCTTCTCCTCTGTATCTGTCTCTCTTCTGTGTCTTCTAAGGATGCTTGTCATTTGATTTCGGGCCCACCTGGATAATCCAAGATGACCTCATCTCGAGATCCTTAGCACATCTGCAAGGACCCTTTCTCCAAATAAGGTCACACTCATAGGTTCCGGGGCTGAGGACATGGATGTGCCTCTTTTGAGGTGTATACGAGACAGATGAAAACATCTGAGAAAGTTCTTTTTCATTTTTGTTGTTGTTGTTTGTTGTTGTTTTAGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCATAGCTCAAGCAGCCTCGAACTCCTGGGCTCAAGCGTTCCTCCCACCTCAGCCTCCCAAGTAACTGGGACTGCAGGCATGCACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGAGGGTCTCACCATGTTGCCCAACCTGGTCTCAAACTCCTGGCCTCAAGCGGTCCTCCCGCCTCAGCCTTCCAAAGTGCTAGGATTACAGGCGTGAGCCACCACGCCCGGCCAGAAAGTTCTTTTTCATAACTCATGGCCAAACCAGAGAGCCTGAGCCCCAACTCCAGAGAAACTCTCTTCCCCTGCTTTCCCAAGGGAGCCTGGGAATCTCCCCTCTGGTTTGGACCAGAGGATGGACAGAATGACCTGTTGCTCGCCTCTCCCTTTCGGAGCCCCTCCAAGGAGGAAATGAAAGGTGGACGGCAGACAGTCGGGGGAGGCATTGCCTGTGGTGGAACCTGCCCTGCAGCTGATGCTGTTTCTTTTAGGAACTTCACGTCCATCTTCTACCCTCACTATGGCAACTGTTACATCTTCAACTGGGGCATGACAGAGAAGGCACTTCCTTCGGCCAGCCCTGGAACTGAATTCGGTGAGTTTTGGTTTATCGTGGGGCCAGAGCCATGAGGCTTTAACCACCCCCACAATGTGGGACTGAAAGACCATCAGCTGTTGCAGGGTGGGACTGAGGGGGGACCAAGGCATCAAGAGGAGTGGCTGCTACCGAGGCTCTACTGTGTGCCAGGGGAGGCCAGGCCAGGCGCTTCCTCAGCCATTCCCGCCCACAATGTTCAGAATCCGTGGGGTAGCAACTGGTGTTCCCATTTTACTGATGAGCAAAGTGAGGACTTGGAAGCAGCACAGCTTCGTGGTCAAGAGCTCAAGCTTCAGCCAGGCGTGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGAGGATTGTTCAAGCCCAAGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAACCCCATCTCTTAAAAAAAAAATACAAAAATTAGCGAGGCATGATGGCACGTACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAAGATCGCTTGAGCTGGGAAGGTCAAGGCAGCAGTGAGCCATGATCACACCACTGCAGCTCCACCATTTACTTGGGTGGTGTTCCTGAGCTCCAGAGCAACCTTCTCAAAGCCTTAGTTTCCCCAATCATAGATTAGTATATAGTAGCAGAGCAGAGCATTTAGTATAGTAAATCGTATCTACCGTGTGAGCCATGATGATGAGTAAATAGTATAAGCCTTGTGAGTCATTACGATGTAATGTGGTAAATCGTTTCACCTGCCTAGGAAGTAGGGAATGCTCCATATATGCTGAGTATTCTGAGCAGTTTTTAAACAACTTGTCCAGGATCATGCAGTTAATACATGGACCAAAAGACATTGCATGTTCTTACCTGTAAGTGGGAGCTAAATGATGTGCACACGTGGATATAGAGTGTGGAAGGAGAGACATCAGAGACTTAGAGGGTGGGAGGGTAGGAGGCAGGTGAGGGACAAGAAATTAATGAGTACAGTATATATGATTCCAGTGAAGGTTACACTAAAAGCCTAGACTTCACCACTGTATAATAATTCCATGTAACAAAACTGCGCTTGAACCCCTTACATTTATACAAATTAGAAAAAGAAAAGAAATACATAACAGTCTCTTAGTCTCTCTGCCTCTCTGGTGTACAGTTTGTTTGTTTGTTTTCTTGAGACAGGGTCTCACTCTGTCACCCAAACTGGAGTGCAGTGGCACGGTCATGGCTCACTGCAGCCTCAACCTCCTGGGCTCAGGTGATCCTCCCACCTCAGCCTCCTGAGGAGCTAGGATTGCAGGTGGCTAATTTTTTGTAGAGATAAGGTTTCATCCTGTTGCCCAGGTTGGTCTTGACCTCCTGGGCTCAAGCAATCTGCCCTCCTTGGCCTCTCAAAGTACTGGGATTACAGATGTGATCCACTGCGCCCAGCTGTACAGTTCTTAAAGAAAGACAGAGACACACAGAGAGAAGCTGAAGGAGTCCATGGAAGTGAGGAAGTGGGGCATGGTGGATGACGGATCCCCCTCCCTCGGGGCTCATGTGTTGCACTGACCCCTAGAGAGGGGCTGGTGGACTCAGGCTGGCTGTGGTTTTGCGGCTTGTGAGCCGGGCACAGGTGGGAGTGGATCCCTCCTCCCATCTCTAGGTTCTGACCTCTGCAACCACCAAGAGGCAGGCTCTCATTCAGCGACCATCGGGGCCGCTGGCCAAGAGGGCAGGTGAGCTGAGTGCCTTTCACTTAGCCCCCATGCTGCTGAGAGCACTGCCACAGAGGTGCCAGTCAACTTACTCCCAGAGGCAGATGGTTATAGTCAGGGAGCCAGCTGCTGTATCAGAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTG
Task1_train_22472
Mutation context: Chromosome 16, Gene SCNN1B (sodium channel epithelial 1 subunit beta). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
CACAGCCTGTCCTGGACCCAAGTCATTCTGCAAGTCAACTAGCTGAGACAAAAGATACAGGAAATGGCTTTCTTATCTGAAAACACGGGAAAATAACACCTGCCCTTGTGGGGTTATTTTGAGAATTAAATGAGATCACGAATACAGAAAGATTCAGCACAGGCCTGGCCCATAAAAGTCACTCAGTGAATGTTTGCTGTGGAGCATAAGGCTTCAAAGACAATACTGCATGGCAGGTGACGTTTTATGTGTGTGCATTATTTGATGTACTTACTCTCATTCCTTCCTGTTTTTATTTTTAATTTTTTACAAATTATTATTGTTTTTTTGATACAGAGTCTCACTCTGTTGCCCAGGCAGGAGTACAGTGGTGCAATCACAGCTCACTACAGCCTCAACCTCCCCAGGCTCAGGTGATCAATCCACATCAGCCTCCCAAGTAGCTGGGACTACAGACACTCACCACTACTCCTGGCTTTTTATTTTATTTTATTTTTTATTTTTTGTAGAGATAGGGTCTCAATTCGTTGGCCAGGCTGATCTCAAACTCCTGGGCTCAGTTGGGTGCAGTGGCTCACGCCTGTAATCGCAGCACTTTGGGAAGCCAAGGTGTGGGGATCACCCGAGGTCAAGAGTTCAAGAGCAGCCTGGCCAACATGATGAAACCCCATCTGCACTAAAAATACACAAATTAGCCGGGTGTGGTGGCGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTGAGATTCTCCTCAGCCTGGAGTGAGATCACACCACTGTACTCCAGCCTGAGCAACATAGTGAGACTCTGTCTCAAAAACAAACAAACAAACAAAACTCCTGGGCTCAAGTGATCCTCCCACTTTGGCCTCCCAAAGTGCTGGAATTACAGGCATAAGCCACCGCTCCCAACCTCCTCTTATTTTTAATAAATAAAAAAAGAACAACATAGAAACATCAAGAGATATTTTTTAAAGCTGCTTACTTTGGAGACTTGAGAACATGCACTTCGACTGAACAGAGTTTGATGAACTCCAGCACACCAGTCATCAGAAGAGGCAAGGAGGAATTCTCCCCTGAGCCTTCTGGTGGGCCCAGGAGTTCCTCGGCTTGTGTCTGAAGGCCCCTGCCTCAGTCTTCAATGAGCTTCTCCTCTGTATCTGTCTCTCTTCTGTGTCTTCTAAGGATGCTTGTCATTTGATTTCGGGCCCACCTGGATAATCCAAGATGACCTCATCTCGAGATCCTTAGCACATCTGCAAGGACCCTTTCTCCAAATAAGGTCACACTCATAGGTTCCGGGGCTGAGGACATGGATGTGCCTCTTTTGAGGTGTATACGAGACAGATGAAAACATCTGAGAAAGTTCTTTTTCATTTTTGTTGTTGTTGTTTGTTGTTGTTTTAGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCATAGCTCAAGCAGCCTCGAACTCCTGGGCTCAAGCGTTCCTCCCACCTCAGCCTCCCAAGTAACTGGGACTGCAGGCATGCACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGAGGGTCTCACCATGTTGCCCAACCTGGTCTCAAACTCCTGGCCTCAAGCGGTCCTCCCGCCTCAGCCTTCCAAAGTGCTAGGATTACAGGCGTGAGCCACCACGCCCGGCCAGAAAGTTCTTTTTCATAACTCATGGCCAAACCAGAGAGCCTGAGCCCCAACTCCAGAGAAACTCTCTTCCCCTGCTTTCCCAAGGGAGCCTGGGAATCTCCCCTCTGGTTTGGACCAGAGGATGGACAGAATGACCTGTTGCTCGCCTCTCCCTTTCGGAGCCCCTCCAAGGAGGAAATGAAAGGTGGACGGCAGACAGTCGGGGGAGGCATTGCCTGTGGTGGAACCTGCCCTGCAGCTGATGCTGTTTCTTTTAGGAACTTCACGTCCATCTTCTACCCTCACTATGGCAACTGTTACATCTTCAACTGGGGCATGACAGAGAAGGCACTTCCTTCGGCCAACCCTGGAACTGAATTCGGTGAGTTTTGGTTTATCGTGGGGCCAGAGCCATGAGGCTTTAACCACCCCCACAATGTGGGACTGAAAGACCATCAGCTGTTGCAGGGTGGGACTGAGGGGGGACCAAGGCATCAAGAGGAGTGGCTGCTACCGAGGCTCTACTGTGTGCCAGGGGAGGCCAGGCCAGGCGCTTCCTCAGCCATTCCCGCCCACAATGTTCAGAATCCGTGGGGTAGCAACTGGTGTTCCCATTTTACTGATGAGCAAAGTGAGGACTTGGAAGCAGCACAGCTTCGTGGTCAAGAGCTCAAGCTTCAGCCAGGCGTGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGAGGATTGTTCAAGCCCAAGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAACCCCATCTCTTAAAAAAAAAATACAAAAATTAGCGAGGCATGATGGCACGTACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAAGATCGCTTGAGCTGGGAAGGTCAAGGCAGCAGTGAGCCATGATCACACCACTGCAGCTCCACCATTTACTTGGGTGGTGTTCCTGAGCTCCAGAGCAACCTTCTCAAAGCCTTAGTTTCCCCAATCATAGATTAGTATATAGTAGCAGAGCAGAGCATTTAGTATAGTAAATCGTATCTACCGTGTGAGCCATGATGATGAGTAAATAGTATAAGCCTTGTGAGTCATTACGATGTAATGTGGTAAATCGTTTCACCTGCCTAGGAAGTAGGGAATGCTCCATATATGCTGAGTATTCTGAGCAGTTTTTAAACAACTTGTCCAGGATCATGCAGTTAATACATGGACCAAAAGACATTGCATGTTCTTACCTGTAAGTGGGAGCTAAATGATGTGCACACGTGGATATAGAGTGTGGAAGGAGAGACATCAGAGACTTAGAGGGTGGGAGGGTAGGAGGCAGGTGAGGGACAAGAAATTAATGAGTACAGTATATATGATTCCAGTGAAGGTTACACTAAAAGCCTAGACTTCACCACTGTATAATAATTCCATGTAACAAAACTGCGCTTGAACCCCTTACATTTATACAAATTAGAAAAAGAAAAGAAATACATAACAGTCTCTTAGTCTCTCTGCCTCTCTGGTGTACAGTTTGTTTGTTTGTTTTCTTGAGACAGGGTCTCACTCTGTCACCCAAACTGGAGTGCAGTGGCACGGTCATGGCTCACTGCAGCCTCAACCTCCTGGGCTCAGGTGATCCTCCCACCTCAGCCTCCTGAGGAGCTAGGATTGCAGGTGGCTAATTTTTTGTAGAGATAAGGTTTCATCCTGTTGCCCAGGTTGGTCTTGACCTCCTGGGCTCAAGCAATCTGCCCTCCTTGGCCTCTCAAAGTACTGGGATTACAGATGTGATCCACTGCGCCCAGCTGTACAGTTCTTAAAGAAAGACAGAGACACACAGAGAGAAGCTGAAGGAGTCCATGGAAGTGAGGAAGTGGGGCATGGTGGATGACGGATCCCCCTCCCTCGGGGCTCATGTGTTGCACTGACCCCTAGAGAGGGGCTGGTGGACTCAGGCTGGCTGTGGTTTTGCGGCTTGTGAGCCGGGCACAGGTGGGAGTGGATCCCTCCTCCCATCTCTAGGTTCTGACCTCTGCAACCACCAAGAGGCAGGCTCTCATTCAGCGACCATCGGGGCCGCTGGCCAAGAGGGCAGGTGAGCTGAGTGCCTTTCACTTAGCCCCCATGCTGCTGAGAGCACTGCCACAGAGGTGCCAGTCAACTTACTCCCAGAGGCAGATGGTTATAGTCAGGGAGCCAGCTGCTGTATCAGAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTG
CACAGCCTGTCCTGGACCCAAGTCATTCTGCAAGTCAACTAGCTGAGACAAAAGATACAGGAAATGGCTTTCTTATCTGAAAACACGGGAAAATAACACCTGCCCTTGTGGGGTTATTTTGAGAATTAAATGAGATCACGAATACAGAAAGATTCAGCACAGGCCTGGCCCATAAAAGTCACTCAGTGAATGTTTGCTGTGGAGCATAAGGCTTCAAAGACAATACTGCATGGCAGGTGACGTTTTATGTGTGTGCATTATTTGATGTACTTACTCTCATTCCTTCCTGTTTTTATTTTTAATTTTTTACAAATTATTATTGTTTTTTTGATACAGAGTCTCACTCTGTTGCCCAGGCAGGAGTACAGTGGTGCAATCACAGCTCACTACAGCCTCAACCTCCCCAGGCTCAGGTGATCAATCCACATCAGCCTCCCAAGTAGCTGGGACTACAGACACTCACCACTACTCCTGGCTTTTTATTTTATTTTATTTTTTATTTTTTGTAGAGATAGGGTCTCAATTCGTTGGCCAGGCTGATCTCAAACTCCTGGGCTCAGTTGGGTGCAGTGGCTCACGCCTGTAATCGCAGCACTTTGGGAAGCCAAGGTGTGGGGATCACCCGAGGTCAAGAGTTCAAGAGCAGCCTGGCCAACATGATGAAACCCCATCTGCACTAAAAATACACAAATTAGCCGGGTGTGGTGGCGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTGAGATTCTCCTCAGCCTGGAGTGAGATCACACCACTGTACTCCAGCCTGAGCAACATAGTGAGACTCTGTCTCAAAAACAAACAAACAAACAAAACTCCTGGGCTCAAGTGATCCTCCCACTTTGGCCTCCCAAAGTGCTGGAATTACAGGCATAAGCCACCGCTCCCAACCTCCTCTTATTTTTAATAAATAAAAAAAGAACAACATAGAAACATCAAGAGATATTTTTTAAAGCTGCTTACTTTGGAGACTTGAGAACATGCACTTCGACTGAACAGAGTTTGATGAACTCCAGCACACCAGTCATCAGAAGAGGCAAGGAGGAATTCTCCCCTGAGCCTTCTGGTGGGCCCAGGAGTTCCTCGGCTTGTGTCTGAAGGCCCCTGCCTCAGTCTTCAATGAGCTTCTCCTCTGTATCTGTCTCTCTTCTGTGTCTTCTAAGGATGCTTGTCATTTGATTTCGGGCCCACCTGGATAATCCAAGATGACCTCATCTCGAGATCCTTAGCACATCTGCAAGGACCCTTTCTCCAAATAAGGTCACACTCATAGGTTCCGGGGCTGAGGACATGGATGTGCCTCTTTTGAGGTGTATACGAGACAGATGAAAACATCTGAGAAAGTTCTTTTTCATTTTTGTTGTTGTTGTTTGTTGTTGTTTTAGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCATAGCTCAAGCAGCCTCGAACTCCTGGGCTCAAGCGTTCCTCCCACCTCAGCCTCCCAAGTAACTGGGACTGCAGGCATGCACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGAGGGTCTCACCATGTTGCCCAACCTGGTCTCAAACTCCTGGCCTCAAGCGGTCCTCCCGCCTCAGCCTTCCAAAGTGCTAGGATTACAGGCGTGAGCCACCACGCCCGGCCAGAAAGTTCTTTTTCATAACTCATGGCCAAACCAGAGAGCCTGAGCCCCAACTCCAGAGAAACTCTCTTCCCCTGCTTTCCCAAGGGAGCCTGGGAATCTCCCCTCTGGTTTGGACCAGAGGATGGACAGAATGACCTGTTGCTCGCCTCTCCCTTTCGGAGCCCCTCCAAGGAGGAAATGAAAGGTGGACGGCAGACAGTCGGGGGAGGCATTGCCTGTGGTGGAACCTGCCCTGCAGCTGATGCTGTTTCTTTTAGGAACTTCACGTCCATCTTCTACCCTCACTATGGCAACTGTTACATCTTCAACTGGGGCATGACAGAGAAGGCACTTCCTTCGGCCAGCCCTGGAACTGAATTCGGTGAGTTTTGGTTTATCGTGGGGCCAGAGCCATGAGGCTTTAACCACCCCCACAATGTGGGACTGAAAGACCATCAGCTGTTGCAGGGTGGGACTGAGGGGGGACCAAGGCATCAAGAGGAGTGGCTGCTACCGAGGCTCTACTGTGTGCCAGGGGAGGCCAGGCCAGGCGCTTCCTCAGCCATTCCCGCCCACAATGTTCAGAATCCGTGGGGTAGCAACTGGTGTTCCCATTTTACTGATGAGCAAAGTGAGGACTTGGAAGCAGCACAGCTTCGTGGTCAAGAGCTCAAGCTTCAGCCAGGCGTGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGAGGATTGTTCAAGCCCAAGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAACCCCATCTCTTAAAAAAAAAATACAAAAATTAGCGAGGCATGATGGCACGTACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAAGATCGCTTGAGCTGGGAAGGTCAAGGCAGCAGTGAGCCATGATCACACCACTGCAGCTCCACCATTTACTTGGGTGGTGTTCCTGAGCTCCAGAGCAACCTTCTCAAAGCCTTAGTTTCCCCAATCATAGATTAGTATATAGTAGCAGAGCAGAGCATTTAGTATAGTAAATCGTATCTACCGTGTGAGCCATGATGATGAGTAAATAGTATAAGCCTTGTGAGTCATTACGATGTAATGTGGTAAATCGTTTCACCTGCCTAGGAAGTAGGGAATGCTCCATATATGCTGAGTATTCTGAGCAGTTTTTAAACAACTTGTCCAGGATCATGCAGTTAATACATGGACCAAAAGACATTGCATGTTCTTACCTGTAAGTGGGAGCTAAATGATGTGCACACGTGGATATAGAGTGTGGAAGGAGAGACATCAGAGACTTAGAGGGTGGGAGGGTAGGAGGCAGGTGAGGGACAAGAAATTAATGAGTACAGTATATATGATTCCAGTGAAGGTTACACTAAAAGCCTAGACTTCACCACTGTATAATAATTCCATGTAACAAAACTGCGCTTGAACCCCTTACATTTATACAAATTAGAAAAAGAAAAGAAATACATAACAGTCTCTTAGTCTCTCTGCCTCTCTGGTGTACAGTTTGTTTGTTTGTTTTCTTGAGACAGGGTCTCACTCTGTCACCCAAACTGGAGTGCAGTGGCACGGTCATGGCTCACTGCAGCCTCAACCTCCTGGGCTCAGGTGATCCTCCCACCTCAGCCTCCTGAGGAGCTAGGATTGCAGGTGGCTAATTTTTTGTAGAGATAAGGTTTCATCCTGTTGCCCAGGTTGGTCTTGACCTCCTGGGCTCAAGCAATCTGCCCTCCTTGGCCTCTCAAAGTACTGGGATTACAGATGTGATCCACTGCGCCCAGCTGTACAGTTCTTAAAGAAAGACAGAGACACACAGAGAGAAGCTGAAGGAGTCCATGGAAGTGAGGAAGTGGGGCATGGTGGATGACGGATCCCCCTCCCTCGGGGCTCATGTGTTGCACTGACCCCTAGAGAGGGGCTGGTGGACTCAGGCTGGCTGTGGTTTTGCGGCTTGTGAGCCGGGCACAGGTGGGAGTGGATCCCTCCTCCCATCTCTAGGTTCTGACCTCTGCAACCACCAAGAGGCAGGCTCTCATTCAGCGACCATCGGGGCCGCTGGCCAAGAGGGCAGGTGAGCTGAGTGCCTTTCACTTAGCCCCCATGCTGCTGAGAGCACTGCCACAGAGGTGCCAGTCAACTTACTCCCAGAGGCAGATGGTTATAGTCAGGGAGCCAGCTGCTGTATCAGAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTG
Task1_train_22473
Assess the clinical impact of this variant on gene SCNN1B (sodium channel epithelial 1 subunit beta), found on Chromosome 16. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Pseudohypoaldosteronism, type IB2, autosomal recessive
CACAGCCTGTCCTGGACCCAAGTCATTCTGCAAGTCAACTAGCTGAGACAAAAGATACAGGAAATGGCTTTCTTATCTGAAAACACGGGAAAATAACACCTGCCCTTGTGGGGTTATTTTGAGAATTAAATGAGATCACGAATACAGAAAGATTCAGCACAGGCCTGGCCCATAAAAGTCACTCAGTGAATGTTTGCTGTGGAGCATAAGGCTTCAAAGACAATACTGCATGGCAGGTGACGTTTTATGTGTGTGCATTATTTGATGTACTTACTCTCATTCCTTCCTGTTTTTATTTTTAATTTTTTACAAATTATTATTGTTTTTTTGATACAGAGTCTCACTCTGTTGCCCAGGCAGGAGTACAGTGGTGCAATCACAGCTCACTACAGCCTCAACCTCCCCAGGCTCAGGTGATCAATCCACATCAGCCTCCCAAGTAGCTGGGACTACAGACACTCACCACTACTCCTGGCTTTTTATTTTATTTTATTTTTTATTTTTTGTAGAGATAGGGTCTCAATTCGTTGGCCAGGCTGATCTCAAACTCCTGGGCTCAGTTGGGTGCAGTGGCTCACGCCTGTAATCGCAGCACTTTGGGAAGCCAAGGTGTGGGGATCACCCGAGGTCAAGAGTTCAAGAGCAGCCTGGCCAACATGATGAAACCCCATCTGCACTAAAAATACACAAATTAGCCGGGTGTGGTGGCGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTGAGATTCTCCTCAGCCTGGAGTGAGATCACACCACTGTACTCCAGCCTGAGCAACATAGTGAGACTCTGTCTCAAAAACAAACAAACAAACAAAACTCCTGGGCTCAAGTGATCCTCCCACTTTGGCCTCCCAAAGTGCTGGAATTACAGGCATAAGCCACCGCTCCCAACCTCCTCTTATTTTTAATAAATAAAAAAAGAACAACATAGAAACATCAAGAGATATTTTTTAAAGCTGCTTACTTTGGAGACTTGAGAACATGCACTTCGACTGAACAGAGTTTGATGAACTCCAGCACACCAGTCATCAGAAGAGGCAAGGAGGAATTCTCCCCTGAGCCTTCTGGTGGGCCCAGGAGTTCCTCGGCTTGTGTCTGAAGGCCCCTGCCTCAGTCTTCAATGAGCTTCTCCTCTGTATCTGTCTCTCTTCTGTGTCTTCTAAGGATGCTTGTCATTTGATTTCGGGCCCACCTGGATAATCCAAGATGACCTCATCTCGAGATCCTTAGCACATCTGCAAGGACCCTTTCTCCAAATAAGGTCACACTCATAGGTTCCGGGGCTGAGGACATGGATGTGCCTCTTTTGAGGTGTATACGAGACAGATGAAAACATCTGAGAAAGTTCTTTTTCATTTTTGTTGTTGTTGTTTGTTGTTGTTTTAGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCATAGCTCAAGCAGCCTCGAACTCCTGGGCTCAAGCGTTCCTCCCACCTCAGCCTCCCAAGTAACTGGGACTGCAGGCATGCACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGAGGGTCTCACCATGTTGCCCAACCTGGTCTCAAACTCCTGGCCTCAAGCGGTCCTCCCGCCTCAGCCTTCCAAAGTGCTAGGATTACAGGCGTGAGCCACCACGCCCGGCCAGAAAGTTCTTTTTCATAACTCATGGCCAAACCAGAGAGCCTGAGCCCCAACTCCAGAGAAACTCTCTTCCCCTGCTTTCCCAAGGGAGCCTGGGAATCTCCCCTCTGGTTTGGACCAGAGGATGGACAGAATGACCTGTTGCTCGCCTCTCCCTTTCGGAGCCCCTCCAAGGAGGAAATGAAAGGTGGACGGCAGACAGTCGGGGGAGGCATTGCCTGTGGTGGAACCTGCCCTGCAGCTGATGCTGTTTCTTTTAGGAACTTCACGTCCATCTTCTACCCTCACTATGGCAACTGTTACATCTTCAACTGGGGCATGACAGAGAAGGCACTTCCTTCGGCCAACCCTGGAACTGAATTCGGTGAGTTTTGGTTTATCGTGGGGCCAGAGCCATGAGGCTTTAACCACCCCCACAATGTGGGACTGAAAGACCATCAGCTGTTGCAGGGTGGGACTGAGGGGGGACCAAGGCATCAAGAGGAGTGGCTGCTACCGAGGCTCTACTGTGTGCCAGGGGAGGCCAGGCCAGGCGCTTCCTCAGCCATTCCCGCCCACAATGTTCAGAATCCGTGGGGTAGCAACTGGTGTTCCCATTTTACTGATGAGCAAAGTGAGGACTTGGAAGCAGCACAGCTTCGTGGTCAAGAGCTCAAGCTTCAGCCAGGCGTGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGAGGATTGTTCAAGCCCAAGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAACCCCATCTCTTAAAAAAAAAATACAAAAATTAGCGAGGCATGATGGCACGTACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAAGATCGCTTGAGCTGGGAAGGTCAAGGCAGCAGTGAGCCATGATCACACCACTGCAGCTCCACCATTTACTTGGGTGGTGTTCCTGAGCTCCAGAGCAACCTTCTCAAAGCCTTAGTTTCCCCAATCATAGATTAGTATATAGTAGCAGAGCAGAGCATTTAGTATAGTAAATCGTATCTACCGTGTGAGCCATGATGATGAGTAAATAGTATAAGCCTTGTGAGTCATTACGATGTAATGTGGTAAATCGTTTCACCTGCCTAGGAAGTAGGGAATGCTCCATATATGCTGAGTATTCTGAGCAGTTTTTAAACAACTTGTCCAGGATCATGCAGTTAATACATGGACCAAAAGACATTGCATGTTCTTACCTGTAAGTGGGAGCTAAATGATGTGCACACGTGGATATAGAGTGTGGAAGGAGAGACATCAGAGACTTAGAGGGTGGGAGGGTAGGAGGCAGGTGAGGGACAAGAAATTAATGAGTACAGTATATATGATTCCAGTGAAGGTTACACTAAAAGCCTAGACTTCACCACTGTATAATAATTCCATGTAACAAAACTGCGCTTGAACCCCTTACATTTATACAAATTAGAAAAAGAAAAGAAATACATAACAGTCTCTTAGTCTCTCTGCCTCTCTGGTGTACAGTTTGTTTGTTTGTTTTCTTGAGACAGGGTCTCACTCTGTCACCCAAACTGGAGTGCAGTGGCACGGTCATGGCTCACTGCAGCCTCAACCTCCTGGGCTCAGGTGATCCTCCCACCTCAGCCTCCTGAGGAGCTAGGATTGCAGGTGGCTAATTTTTTGTAGAGATAAGGTTTCATCCTGTTGCCCAGGTTGGTCTTGACCTCCTGGGCTCAAGCAATCTGCCCTCCTTGGCCTCTCAAAGTACTGGGATTACAGATGTGATCCACTGCGCCCAGCTGTACAGTTCTTAAAGAAAGACAGAGACACACAGAGAGAAGCTGAAGGAGTCCATGGAAGTGAGGAAGTGGGGCATGGTGGATGACGGATCCCCCTCCCTCGGGGCTCATGTGTTGCACTGACCCCTAGAGAGGGGCTGGTGGACTCAGGCTGGCTGTGGTTTTGCGGCTTGTGAGCCGGGCACAGGTGGGAGTGGATCCCTCCTCCCATCTCTAGGTTCTGACCTCTGCAACCACCAAGAGGCAGGCTCTCATTCAGCGACCATCGGGGCCGCTGGCCAAGAGGGCAGGTGAGCTGAGTGCCTTTCACTTAGCCCCCATGCTGCTGAGAGCACTGCCACAGAGGTGCCAGTCAACTTACTCCCAGAGGCAGATGGTTATAGTCAGGGAGCCAGCTGCTGTATCAGAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTG
CACAGCCTGTCCTGGACCCAAGTCATTCTGCAAGTCAACTAGCTGAGACAAAAGATACAGGAAATGGCTTTCTTATCTGAAAACACGGGAAAATAACACCTGCCCTTGTGGGGTTATTTTGAGAATTAAATGAGATCACGAATACAGAAAGATTCAGCACAGGCCTGGCCCATAAAAGTCACTCAGTGAATGTTTGCTGTGGAGCATAAGGCTTCAAAGACAATACTGCATGGCAGGTGACGTTTTATGTGTGTGCATTATTTGATGTACTTACTCTCATTCCTTCCTGTTTTTATTTTTAATTTTTTACAAATTATTATTGTTTTTTTGATACAGAGTCTCACTCTGTTGCCCAGGCAGGAGTACAGTGGTGCAATCACAGCTCACTACAGCCTCAACCTCCCCAGGCTCAGGTGATCAATCCACATCAGCCTCCCAAGTAGCTGGGACTACAGACACTCACCACTACTCCTGGCTTTTTATTTTATTTTATTTTTTATTTTTTGTAGAGATAGGGTCTCAATTCGTTGGCCAGGCTGATCTCAAACTCCTGGGCTCAGTTGGGTGCAGTGGCTCACGCCTGTAATCGCAGCACTTTGGGAAGCCAAGGTGTGGGGATCACCCGAGGTCAAGAGTTCAAGAGCAGCCTGGCCAACATGATGAAACCCCATCTGCACTAAAAATACACAAATTAGCCGGGTGTGGTGGCGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTGAGATTCTCCTCAGCCTGGAGTGAGATCACACCACTGTACTCCAGCCTGAGCAACATAGTGAGACTCTGTCTCAAAAACAAACAAACAAACAAAACTCCTGGGCTCAAGTGATCCTCCCACTTTGGCCTCCCAAAGTGCTGGAATTACAGGCATAAGCCACCGCTCCCAACCTCCTCTTATTTTTAATAAATAAAAAAAGAACAACATAGAAACATCAAGAGATATTTTTTAAAGCTGCTTACTTTGGAGACTTGAGAACATGCACTTCGACTGAACAGAGTTTGATGAACTCCAGCACACCAGTCATCAGAAGAGGCAAGGAGGAATTCTCCCCTGAGCCTTCTGGTGGGCCCAGGAGTTCCTCGGCTTGTGTCTGAAGGCCCCTGCCTCAGTCTTCAATGAGCTTCTCCTCTGTATCTGTCTCTCTTCTGTGTCTTCTAAGGATGCTTGTCATTTGATTTCGGGCCCACCTGGATAATCCAAGATGACCTCATCTCGAGATCCTTAGCACATCTGCAAGGACCCTTTCTCCAAATAAGGTCACACTCATAGGTTCCGGGGCTGAGGACATGGATGTGCCTCTTTTGAGGTGTATACGAGACAGATGAAAACATCTGAGAAAGTTCTTTTTCATTTTTGTTGTTGTTGTTTGTTGTTGTTTTAGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCATAGCTCAAGCAGCCTCGAACTCCTGGGCTCAAGCGTTCCTCCCACCTCAGCCTCCCAAGTAACTGGGACTGCAGGCATGCACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGAGGGTCTCACCATGTTGCCCAACCTGGTCTCAAACTCCTGGCCTCAAGCGGTCCTCCCGCCTCAGCCTTCCAAAGTGCTAGGATTACAGGCGTGAGCCACCACGCCCGGCCAGAAAGTTCTTTTTCATAACTCATGGCCAAACCAGAGAGCCTGAGCCCCAACTCCAGAGAAACTCTCTTCCCCTGCTTTCCCAAGGGAGCCTGGGAATCTCCCCTCTGGTTTGGACCAGAGGATGGACAGAATGACCTGTTGCTCGCCTCTCCCTTTCGGAGCCCCTCCAAGGAGGAAATGAAAGGTGGACGGCAGACAGTCGGGGGAGGCATTGCCTGTGGTGGAACCTGCCCTGCAGCTGATGCTGTTTCTTTTAGGAACTTCACGTCCATCTTCTACCCTCACTATGGCAACTGTTACATCTTCAACTGGGGCATGACAGAGAAGGCACTTCCTTCGGCCAGCCCTGGAACTGAATTCGGTGAGTTTTGGTTTATCGTGGGGCCAGAGCCATGAGGCTTTAACCACCCCCACAATGTGGGACTGAAAGACCATCAGCTGTTGCAGGGTGGGACTGAGGGGGGACCAAGGCATCAAGAGGAGTGGCTGCTACCGAGGCTCTACTGTGTGCCAGGGGAGGCCAGGCCAGGCGCTTCCTCAGCCATTCCCGCCCACAATGTTCAGAATCCGTGGGGTAGCAACTGGTGTTCCCATTTTACTGATGAGCAAAGTGAGGACTTGGAAGCAGCACAGCTTCGTGGTCAAGAGCTCAAGCTTCAGCCAGGCGTGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGAGGATTGTTCAAGCCCAAGAGTTCGAGACCAGCCTGGGCAACAAGGTGAAACCCCATCTCTTAAAAAAAAAATACAAAAATTAGCGAGGCATGATGGCACGTACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAAGATCGCTTGAGCTGGGAAGGTCAAGGCAGCAGTGAGCCATGATCACACCACTGCAGCTCCACCATTTACTTGGGTGGTGTTCCTGAGCTCCAGAGCAACCTTCTCAAAGCCTTAGTTTCCCCAATCATAGATTAGTATATAGTAGCAGAGCAGAGCATTTAGTATAGTAAATCGTATCTACCGTGTGAGCCATGATGATGAGTAAATAGTATAAGCCTTGTGAGTCATTACGATGTAATGTGGTAAATCGTTTCACCTGCCTAGGAAGTAGGGAATGCTCCATATATGCTGAGTATTCTGAGCAGTTTTTAAACAACTTGTCCAGGATCATGCAGTTAATACATGGACCAAAAGACATTGCATGTTCTTACCTGTAAGTGGGAGCTAAATGATGTGCACACGTGGATATAGAGTGTGGAAGGAGAGACATCAGAGACTTAGAGGGTGGGAGGGTAGGAGGCAGGTGAGGGACAAGAAATTAATGAGTACAGTATATATGATTCCAGTGAAGGTTACACTAAAAGCCTAGACTTCACCACTGTATAATAATTCCATGTAACAAAACTGCGCTTGAACCCCTTACATTTATACAAATTAGAAAAAGAAAAGAAATACATAACAGTCTCTTAGTCTCTCTGCCTCTCTGGTGTACAGTTTGTTTGTTTGTTTTCTTGAGACAGGGTCTCACTCTGTCACCCAAACTGGAGTGCAGTGGCACGGTCATGGCTCACTGCAGCCTCAACCTCCTGGGCTCAGGTGATCCTCCCACCTCAGCCTCCTGAGGAGCTAGGATTGCAGGTGGCTAATTTTTTGTAGAGATAAGGTTTCATCCTGTTGCCCAGGTTGGTCTTGACCTCCTGGGCTCAAGCAATCTGCCCTCCTTGGCCTCTCAAAGTACTGGGATTACAGATGTGATCCACTGCGCCCAGCTGTACAGTTCTTAAAGAAAGACAGAGACACACAGAGAGAAGCTGAAGGAGTCCATGGAAGTGAGGAAGTGGGGCATGGTGGATGACGGATCCCCCTCCCTCGGGGCTCATGTGTTGCACTGACCCCTAGAGAGGGGCTGGTGGACTCAGGCTGGCTGTGGTTTTGCGGCTTGTGAGCCGGGCACAGGTGGGAGTGGATCCCTCCTCCCATCTCTAGGTTCTGACCTCTGCAACCACCAAGAGGCAGGCTCTCATTCAGCGACCATCGGGGCCGCTGGCCAAGAGGGCAGGTGAGCTGAGTGCCTTTCACTTAGCCCCCATGCTGCTGAGAGCACTGCCACAGAGGTGCCAGTCAACTTACTCCCAGAGGCAGATGGTTATAGTCAGGGAGCCAGCTGCTGTATCAGAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTG
Task1_train_22474
This is a variant in SCNN1B (sodium channel epithelial 1 subunit beta), located on Chromosome 16. Is this mutation a likely cause of disease or not?
Pathogenic; Liddle syndrome 1
GAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCGCCACAATGCCCAACTAATTTTTGTATTTTTTTTTCTCTATTTTGATATGGAGTTTTGCTCTGTCGTCCTGGCTGCAGTGCAGTGGCGCAATCTCGGCTCACTACAACCTCTGTCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGTTGGGATTACAGGTGGCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTAGCCAGGTTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCGCTTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTGCCCGGCCAAGGAGCTCATGTTTAATGAGGCCCTTAGCACATCACCCCGCAGGTAGCAAGTGCTCAACTAGCCCTTATTGTCCTAACCAGAGGGACTCAACTCCACGTAGCTCAGGACCGTGGTGCGTGGGAGACTGGGTCCAGTCCCTTCCCTTGAGAACAGTCAAGAGGGGAAGGAAGACAGACAATAAAAGAGCAATCACACAAATGAGGCAGGTACTCAGAAGGAAAGTTCCGGGGCTAGGAAAGTGTACAACCAAGACCCTGACACCTCGTCTGAGCCATCAGAGAACGTTTCTGGAGGAAGTGATGCTGGTTGAGATCTGAGGGAAGAGCATGTGTTTCTAGGGGAAGGGAAGGGGCAGAGACAGCATTCCAGAGCTAGGGAATAGCACTCCAGATTGAGGAACAGCATTCCAGGTGAGAGAACAGAATTCCAGAGCAAGGAACAGCACTCCAGGTGAGGGAACAGCACTCCAGAGTGAGGAACAGCATTCCAGAGTGAGGGAACAGCATTTGCAAAGGCATAGCAGGAGGAAGGCGTGCAGAAGCTCGGAGGCATTGAACGGGGACAGCGAGGGCACCTGTGGTGTGAGGTGGGGTGGCATGGGTGGGCCGTGGCCATGCTATGCCTCCTTGATCTACCTCCTGATCAGAAAAGAGATCACGGGAGGCAAGAGACACCTAGGGAGGAGGCTACGTAAGAGCCTGCCTTAGAGATGATGGGGGCTTTGCAGAAGGCAAGCAGTATTTGAGGACTGAGTTTTTGCAAAGTGGAGCCAGCCTCCTTGGCGGTCCCTGGAGGTCCCCTGGCCGGAGGGAGCTTGGAGAAGTGGGTAGTGGGGTCTCCTTTCTGCCTCAGGAGAAAGTTCAGGCAGCCCTCACCCCACCCTCCCCACAGGCCTGAAGTTGATCCTGGACATAGGCCAGGAAGACTACGTCCCCTTCCTTGCGTCCACGGCCGGGGTCAGGCTGATGCTTCACGAGCAGAGGTCATACCCCTTCATCAGAGATGAGGGCATCTACGCCATGTCGGGGACAGAGACGTCCATCGGGGTACTCGTGGTATGGCCGGAGCCCAAGGGCAGTCCTAGAGGGTCTGAGGGTGGGAGCCCACCTGTCCAGGGCCAACTGCCCTTGGCCTGGGAGGAGGGGATCTGGGCCCCCCAGCCCTGGCCTTCCTTCCTTTTGGCTGGAATCCCCCCAGGGTGGCCCAAGCTTTAGGGGAAGGTGAGCCCTCTGGCGCCCCCTCTGGCGCCCCCCCTGGCACCTGCAGGGGTCCACAGCCCTCTGTCCCCAAATGCTTGATAGAAGGGAGGTGCAGAAAGGGCTTCCTGGGGTGACCAGTGTCCCCCTCAAGCAACCCCTCTAAACACAGGACAAGCTTCAGCGCATGGGGGAGCCCTACAGCCCGTGCACCGTGAATGGTTCTGAGGTCCCCGTCCAAAACTTCTACAGTGACTACAACACGACCTACTCCATCCAGGTGGGAAGGTGGTGCACGCCTCATGCCCCGGGGCCCCTGTCCGGGTTTATGGGGCCAAGGCCTCAGTACTCCGGGAGAGCTGGCCCCAGCAAGTCTGGCTCTGCTGGGCCTTTGTAGGTTGCCACGGGGCACCCCGGGCCTGTGGGACCAGTCACTTTCCTGGGCTCTCTCACCAGGGCCTAGGGTTGGCCACTTCTCATCCCCACATTGGCAGGTGTACCCCTGGGGAAGCCCAGGGGATTATGGGGATCTTACTCTGGGGTTTCCCAAGATGAAAACAAAAAATAGCAGCTAACACCATCAAGCTTCCATTGTGTGTGAAATGCTGTGCGAAGGGCTGGAACACATTCCATCGTCATTTAATCTTTCAACTGCCTCCTGCCATGAATCTACAATATAGTAATGACAGCAGCATTTATTGATAAACTAATAATAGCAGGGTTACCATGTGTTAGGCAGTCACTGTTGTAAGTAATTTACATGTATATTACATCATTTAACTTTCACAACAACCCTAAGATGTAGATACTATTATCATTCCCATTCTGGGAATGAGGAAATTGGGATTGACAGACCCCAGTTCAAATGCATCATCAATTTACCTGAGAAGTCCCTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCGGTGGCGTGATATTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCTGCCTCAGCCTCCCGTGTAGCTGGGACTACAGGTGCCCACCGCTACACCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCGCCTCGGCCTCCCAAAGTGCTGGGATAACAGGCATGAGCCACCGCACCCGGACTTTATTATTATTTTTTTAAAAGAGATTGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGTGCGAAGCGGGTACATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAAAAAATTAGCCAGGCGTCGTGGCACACGCCTGTAGTCCCAGCTGTGCAGGGGGCTGAGGCAAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGATATCACGCCACTGCACTCCAGCCTGAGTGACAGAGTGAGACTCTTGTCTCAAAAAAGTAAAATAATAAAATAAAAAAGAGAGACAGGGTCTTGCTCTGTTACCCAGGCTGAAGTGCTGTGGTGCCATCATAGTTCACTGCAGCCTCGAACTCTTGGATTCAAGCAATCCGCCTGCCTCAGCCTCCCTAGTAGCCAGGACCACAGGCATGAGCCACTGTCCCTGGCTAATTTCTTAATTTTTAAAATTTTTTGCAGAGACAGAGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGGCTCAAGCAATCCTCCCACTCTGGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGCGCCCACTGGAAGTCCCTCTTTGCATCTGCCTTCAATCCCCCTTGCTGTAGCTGGAGGCTTCCTTCTCATCCTGATCTCCAGAGTTAACCCAGACCTGCCACTAGTCCTGGCCCCCTTGGAGAGGGCAGACTGAATCCTTGCAAAGGTGACAAAAATGACCACTCGCTGATACTTCCTCTCCAGCCCAGTCTGCCTTGCCATATCAGTGCACTGAGTCATAACAAGAGGGCAGCCCAGTGCCTGCCTCAGTGTCTGGGTGCCCGAGCATGGCATGGTTTGCCCTTTCCCCGTAGGAAATGACCCTCCTGGTGCCCACCTGCCCACCCATTGCCTGGCTGGTTTGGCCACCTCGCGTCTGGAGGGACTTCTGCCCATTATGGAGAACTCTAGCCGTCATCTGAGCCTCTGGAGGGACAGACAGACAGACAGGACAGTACAGGGAGGTGGGAAACACGGAGAAGAAG
GAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCGCCACAATGCCCAACTAATTTTTGTATTTTTTTTTCTCTATTTTGATATGGAGTTTTGCTCTGTCGTCCTGGCTGCAGTGCAGTGGCGCAATCTCGGCTCACTACAACCTCTGTCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGTTGGGATTACAGGTGGCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTAGCCAGGTTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCGCTTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTGCCCGGCCAAGGAGCTCATGTTTAATGAGGCCCTTAGCACATCACCCCGCAGGTAGCAAGTGCTCAACTAGCCCTTATTGTCCTAACCAGAGGGACTCAACTCCACGTAGCTCAGGACCGTGGTGCGTGGGAGACTGGGTCCAGTCCCTTCCCTTGAGAACAGTCAAGAGGGGAAGGAAGACAGACAATAAAAGAGCAATCACACAAATGAGGCAGGTACTCAGAAGGAAAGTTCCGGGGCTAGGAAAGTGTACAACCAAGACCCTGACACCTCGTCTGAGCCATCAGAGAACGTTTCTGGAGGAAGTGATGCTGGTTGAGATCTGAGGGAAGAGCATGTGTTTCTAGGGGAAGGGAAGGGGCAGAGACAGCATTCCAGAGCTAGGGAATAGCACTCCAGATTGAGGAACAGCATTCCAGGTGAGAGAACAGAATTCCAGAGCAAGGAACAGCACTCCAGGTGAGGGAACAGCACTCCAGAGTGAGGAACAGCATTCCAGAGTGAGGGAACAGCATTTGCAAAGGCATAGCAGGAGGAAGGCGTGCAGAAGCTCGGAGGCATTGAACGGGGACAGCGAGGGCACCTGTGGTGTGAGGTGGGGTGGCATGGGTGGGCCGTGGCCATGCTATGCCTCCTTGATCTACCTCCTGATCAGAAAAGAGATCACGGGAGGCAAGAGACACCTAGGGAGGAGGCTACGTAAGAGCCTGCCTTAGAGATGATGGGGGCTTTGCAGAAGGCAAGCAGTATTTGAGGACTGAGTTTTTGCAAAGTGGAGCCAGCCTCCTTGGCGGTCCCTGGAGGTCCCCTGGCCGGAGGGAGCTTGGAGAAGTGGGTAGTGGGGTCTCCTTTCTGCCTCAGGAGAAAGTTCAGGCAGCCCTCACCCCACCCTCCCCACAGGCCTGAAGTTGATCCTGGACATAGGCCAGGAAGACTACGTCCCCTTCCTTGCGTCCACGGCCGGGGTCAGGCTGATGCTTCACGAGCAGAGGTCATACCCCTTCATCAGAGATGAGGGCATCTACGCCATGTCGGGGACAGAGACGTCCATCGGGGTACTCGTGGTATGGCCGGAGCCCAAGGGCAGTCCTAGAGGGTCTGAGGGTGGGAGCCCACCTGTCCAGGGCCAACTGCCCTTGGCCTGGGAGGAGGGGATCTGGGCCCCCCAGCCCTGGCCTTCCTTCCTTTTGGCTGGAATCCCCCCAGGGTGGCCCAAGCTTTAGGGGAAGGTGAGCCCTCTGGCGCCCCCTCTGGCGCCCCCCCTGGCACCTGCAGGGGTCCACAGCCCTCTGTCCCCAAATGCTTGATAGAAGGGAGGTGCAGAAAGGGCTTCCTGGGGTGACCAGTGTCCCCCTCAAGCAACCCCTCTAAACACAGGACAAGCTTCAGCGCATGGGGGAGCCCTACAGCCCGTGCACCGTGAATGGTTCTGAGGTCACCGTCCAAAACTTCTACAGTGACTACAACACGACCTACTCCATCCAGGTGGGAAGGTGGTGCACGCCTCATGCCCCGGGGCCCCTGTCCGGGTTTATGGGGCCAAGGCCTCAGTACTCCGGGAGAGCTGGCCCCAGCAAGTCTGGCTCTGCTGGGCCTTTGTAGGTTGCCACGGGGCACCCCGGGCCTGTGGGACCAGTCACTTTCCTGGGCTCTCTCACCAGGGCCTAGGGTTGGCCACTTCTCATCCCCACATTGGCAGGTGTACCCCTGGGGAAGCCCAGGGGATTATGGGGATCTTACTCTGGGGTTTCCCAAGATGAAAACAAAAAATAGCAGCTAACACCATCAAGCTTCCATTGTGTGTGAAATGCTGTGCGAAGGGCTGGAACACATTCCATCGTCATTTAATCTTTCAACTGCCTCCTGCCATGAATCTACAATATAGTAATGACAGCAGCATTTATTGATAAACTAATAATAGCAGGGTTACCATGTGTTAGGCAGTCACTGTTGTAAGTAATTTACATGTATATTACATCATTTAACTTTCACAACAACCCTAAGATGTAGATACTATTATCATTCCCATTCTGGGAATGAGGAAATTGGGATTGACAGACCCCAGTTCAAATGCATCATCAATTTACCTGAGAAGTCCCTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCGGTGGCGTGATATTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCTGCCTCAGCCTCCCGTGTAGCTGGGACTACAGGTGCCCACCGCTACACCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCGCCTCGGCCTCCCAAAGTGCTGGGATAACAGGCATGAGCCACCGCACCCGGACTTTATTATTATTTTTTTAAAAGAGATTGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGTGCGAAGCGGGTACATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAAAAAATTAGCCAGGCGTCGTGGCACACGCCTGTAGTCCCAGCTGTGCAGGGGGCTGAGGCAAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGATATCACGCCACTGCACTCCAGCCTGAGTGACAGAGTGAGACTCTTGTCTCAAAAAAGTAAAATAATAAAATAAAAAAGAGAGACAGGGTCTTGCTCTGTTACCCAGGCTGAAGTGCTGTGGTGCCATCATAGTTCACTGCAGCCTCGAACTCTTGGATTCAAGCAATCCGCCTGCCTCAGCCTCCCTAGTAGCCAGGACCACAGGCATGAGCCACTGTCCCTGGCTAATTTCTTAATTTTTAAAATTTTTTGCAGAGACAGAGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGGCTCAAGCAATCCTCCCACTCTGGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGCGCCCACTGGAAGTCCCTCTTTGCATCTGCCTTCAATCCCCCTTGCTGTAGCTGGAGGCTTCCTTCTCATCCTGATCTCCAGAGTTAACCCAGACCTGCCACTAGTCCTGGCCCCCTTGGAGAGGGCAGACTGAATCCTTGCAAAGGTGACAAAAATGACCACTCGCTGATACTTCCTCTCCAGCCCAGTCTGCCTTGCCATATCAGTGCACTGAGTCATAACAAGAGGGCAGCCCAGTGCCTGCCTCAGTGTCTGGGTGCCCGAGCATGGCATGGTTTGCCCTTTCCCCGTAGGAAATGACCCTCCTGGTGCCCACCTGCCCACCCATTGCCTGGCTGGTTTGGCCACCTCGCGTCTGGAGGGACTTCTGCCCATTATGGAGAACTCTAGCCGTCATCTGAGCCTCTGGAGGGACAGACAGACAGACAGGACAGTACAGGGAGGTGGGAAACACGGAGAAGAAG
Task1_train_22475
This variant impacts the gene SCNN1B (sodium channel epithelial 1 subunit beta) on Chromosome 16. Is the change likely to result in a pathogenic outcome?
Pathogenic; Pseudohypoaldosteronism, type IB2, autosomal recessive
GAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCGCCACAATGCCCAACTAATTTTTGTATTTTTTTTTCTCTATTTTGATATGGAGTTTTGCTCTGTCGTCCTGGCTGCAGTGCAGTGGCGCAATCTCGGCTCACTACAACCTCTGTCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGTTGGGATTACAGGTGGCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTAGCCAGGTTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCGCTTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTGCCCGGCCAAGGAGCTCATGTTTAATGAGGCCCTTAGCACATCACCCCGCAGGTAGCAAGTGCTCAACTAGCCCTTATTGTCCTAACCAGAGGGACTCAACTCCACGTAGCTCAGGACCGTGGTGCGTGGGAGACTGGGTCCAGTCCCTTCCCTTGAGAACAGTCAAGAGGGGAAGGAAGACAGACAATAAAAGAGCAATCACACAAATGAGGCAGGTACTCAGAAGGAAAGTTCCGGGGCTAGGAAAGTGTACAACCAAGACCCTGACACCTCGTCTGAGCCATCAGAGAACGTTTCTGGAGGAAGTGATGCTGGTTGAGATCTGAGGGAAGAGCATGTGTTTCTAGGGGAAGGGAAGGGGCAGAGACAGCATTCCAGAGCTAGGGAATAGCACTCCAGATTGAGGAACAGCATTCCAGGTGAGAGAACAGAATTCCAGAGCAAGGAACAGCACTCCAGGTGAGGGAACAGCACTCCAGAGTGAGGAACAGCATTCCAGAGTGAGGGAACAGCATTTGCAAAGGCATAGCAGGAGGAAGGCGTGCAGAAGCTCGGAGGCATTGAACGGGGACAGCGAGGGCACCTGTGGTGTGAGGTGGGGTGGCATGGGTGGGCCGTGGCCATGCTATGCCTCCTTGATCTACCTCCTGATCAGAAAAGAGATCACGGGAGGCAAGAGACACCTAGGGAGGAGGCTACGTAAGAGCCTGCCTTAGAGATGATGGGGGCTTTGCAGAAGGCAAGCAGTATTTGAGGACTGAGTTTTTGCAAAGTGGAGCCAGCCTCCTTGGCGGTCCCTGGAGGTCCCCTGGCCGGAGGGAGCTTGGAGAAGTGGGTAGTGGGGTCTCCTTTCTGCCTCAGGAGAAAGTTCAGGCAGCCCTCACCCCACCCTCCCCACAGGCCTGAAGTTGATCCTGGACATAGGCCAGGAAGACTACGTCCCCTTCCTTGCGTCCACGGCCGGGGTCAGGCTGATGCTTCACGAGCAGAGGTCATACCCCTTCATCAGAGATGAGGGCATCTACGCCATGTCGGGGACAGAGACGTCCATCGGGGTACTCGTGGTATGGCCGGAGCCCAAGGGCAGTCCTAGAGGGTCTGAGGGTGGGAGCCCACCTGTCCAGGGCCAACTGCCCTTGGCCTGGGAGGAGGGGATCTGGGCCCCCCAGCCCTGGCCTTCCTTCCTTTTGGCTGGAATCCCCCCAGGGTGGCCCAAGCTTTAGGGGAAGGTGAGCCCTCTGGCGCCCCCTCTGGCGCCCCCCCTGGCACCTGCAGGGGTCCACAGCCCTCTGTCCCCAAATGCTTGATAGAAGGGAGGTGCAGAAAGGGCTTCCTGGGGTGACCAGTGTCCCCCTCAAGCAACCCCTCTAAACACAGGACAAGCTTCAGCGCATGGGGGAGCCCTACAGCCCGTGCACCGTGAATGGTTCTGAGGTCCCCGTCCAAAACTTCTACAGTGACTACAACACGACCTACTCCATCCAGGTGGGAAGGTGGTGCACGCCTCATGCCCCGGGGCCCCTGTCCGGGTTTATGGGGCCAAGGCCTCAGTACTCCGGGAGAGCTGGCCCCAGCAAGTCTGGCTCTGCTGGGCCTTTGTAGGTTGCCACGGGGCACCCCGGGCCTGTGGGACCAGTCACTTTCCTGGGCTCTCTCACCAGGGCCTAGGGTTGGCCACTTCTCATCCCCACATTGGCAGGTGTACCCCTGGGGAAGCCCAGGGGATTATGGGGATCTTACTCTGGGGTTTCCCAAGATGAAAACAAAAAATAGCAGCTAACACCATCAAGCTTCCATTGTGTGTGAAATGCTGTGCGAAGGGCTGGAACACATTCCATCGTCATTTAATCTTTCAACTGCCTCCTGCCATGAATCTACAATATAGTAATGACAGCAGCATTTATTGATAAACTAATAATAGCAGGGTTACCATGTGTTAGGCAGTCACTGTTGTAAGTAATTTACATGTATATTACATCATTTAACTTTCACAACAACCCTAAGATGTAGATACTATTATCATTCCCATTCTGGGAATGAGGAAATTGGGATTGACAGACCCCAGTTCAAATGCATCATCAATTTACCTGAGAAGTCCCTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCGGTGGCGTGATATTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCTGCCTCAGCCTCCCGTGTAGCTGGGACTACAGGTGCCCACCGCTACACCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCGCCTCGGCCTCCCAAAGTGCTGGGATAACAGGCATGAGCCACCGCACCCGGACTTTATTATTATTTTTTTAAAAGAGATTGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGTGCGAAGCGGGTACATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAAAAAATTAGCCAGGCGTCGTGGCACACGCCTGTAGTCCCAGCTGTGCAGGGGGCTGAGGCAAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGATATCACGCCACTGCACTCCAGCCTGAGTGACAGAGTGAGACTCTTGTCTCAAAAAAGTAAAATAATAAAATAAAAAAGAGAGACAGGGTCTTGCTCTGTTACCCAGGCTGAAGTGCTGTGGTGCCATCATAGTTCACTGCAGCCTCGAACTCTTGGATTCAAGCAATCCGCCTGCCTCAGCCTCCCTAGTAGCCAGGACCACAGGCATGAGCCACTGTCCCTGGCTAATTTCTTAATTTTTAAAATTTTTTGCAGAGACAGAGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGGCTCAAGCAATCCTCCCACTCTGGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGCGCCCACTGGAAGTCCCTCTTTGCATCTGCCTTCAATCCCCCTTGCTGTAGCTGGAGGCTTCCTTCTCATCCTGATCTCCAGAGTTAACCCAGACCTGCCACTAGTCCTGGCCCCCTTGGAGAGGGCAGACTGAATCCTTGCAAAGGTGACAAAAATGACCACTCGCTGATACTTCCTCTCCAGCCCAGTCTGCCTTGCCATATCAGTGCACTGAGTCATAACAAGAGGGCAGCCCAGTGCCTGCCTCAGTGTCTGGGTGCCCGAGCATGGCATGGTTTGCCCTTTCCCCGTAGGAAATGACCCTCCTGGTGCCCACCTGCCCACCCATTGCCTGGCTGGTTTGGCCACCTCGCGTCTGGAGGGACTTCTGCCCATTATGGAGAACTCTAGCCGTCATCTGAGCCTCTGGAGGGACAGACAGACAGACAGGACAGTACAGGGAGGTGGGAAACACGGAGAAGAAG
GAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCGCCACAATGCCCAACTAATTTTTGTATTTTTTTTTCTCTATTTTGATATGGAGTTTTGCTCTGTCGTCCTGGCTGCAGTGCAGTGGCGCAATCTCGGCTCACTACAACCTCTGTCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGTTGGGATTACAGGTGGCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTAGCCAGGTTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCGCTTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTGCCCGGCCAAGGAGCTCATGTTTAATGAGGCCCTTAGCACATCACCCCGCAGGTAGCAAGTGCTCAACTAGCCCTTATTGTCCTAACCAGAGGGACTCAACTCCACGTAGCTCAGGACCGTGGTGCGTGGGAGACTGGGTCCAGTCCCTTCCCTTGAGAACAGTCAAGAGGGGAAGGAAGACAGACAATAAAAGAGCAATCACACAAATGAGGCAGGTACTCAGAAGGAAAGTTCCGGGGCTAGGAAAGTGTACAACCAAGACCCTGACACCTCGTCTGAGCCATCAGAGAACGTTTCTGGAGGAAGTGATGCTGGTTGAGATCTGAGGGAAGAGCATGTGTTTCTAGGGGAAGGGAAGGGGCAGAGACAGCATTCCAGAGCTAGGGAATAGCACTCCAGATTGAGGAACAGCATTCCAGGTGAGAGAACAGAATTCCAGAGCAAGGAACAGCACTCCAGGTGAGGGAACAGCACTCCAGAGTGAGGAACAGCATTCCAGAGTGAGGGAACAGCATTTGCAAAGGCATAGCAGGAGGAAGGCGTGCAGAAGCTCGGAGGCATTGAACGGGGACAGCGAGGGCACCTGTGGTGTGAGGTGGGGTGGCATGGGTGGGCCGTGGCCATGCTATGCCTCCTTGATCTACCTCCTGATCAGAAAAGAGATCACGGGAGGCAAGAGACACCTAGGGAGGAGGCTACGTAAGAGCCTGCCTTAGAGATGATGGGGGCTTTGCAGAAGGCAAGCAGTATTTGAGGACTGAGTTTTTGCAAAGTGGAGCCAGCCTCCTTGGCGGTCCCTGGAGGTCCCCTGGCCGGAGGGAGCTTGGAGAAGTGGGTAGTGGGGTCTCCTTTCTGCCTCAGGAGAAAGTTCAGGCAGCCCTCACCCCACCCTCCCCACAGGCCTGAAGTTGATCCTGGACATAGGCCAGGAAGACTACGTCCCCTTCCTTGCGTCCACGGCCGGGGTCAGGCTGATGCTTCACGAGCAGAGGTCATACCCCTTCATCAGAGATGAGGGCATCTACGCCATGTCGGGGACAGAGACGTCCATCGGGGTACTCGTGGTATGGCCGGAGCCCAAGGGCAGTCCTAGAGGGTCTGAGGGTGGGAGCCCACCTGTCCAGGGCCAACTGCCCTTGGCCTGGGAGGAGGGGATCTGGGCCCCCCAGCCCTGGCCTTCCTTCCTTTTGGCTGGAATCCCCCCAGGGTGGCCCAAGCTTTAGGGGAAGGTGAGCCCTCTGGCGCCCCCTCTGGCGCCCCCCCTGGCACCTGCAGGGGTCCACAGCCCTCTGTCCCCAAATGCTTGATAGAAGGGAGGTGCAGAAAGGGCTTCCTGGGGTGACCAGTGTCCCCCTCAAGCAACCCCTCTAAACACAGGACAAGCTTCAGCGCATGGGGGAGCCCTACAGCCCGTGCACCGTGAATGGTTCTGAGGTCACCGTCCAAAACTTCTACAGTGACTACAACACGACCTACTCCATCCAGGTGGGAAGGTGGTGCACGCCTCATGCCCCGGGGCCCCTGTCCGGGTTTATGGGGCCAAGGCCTCAGTACTCCGGGAGAGCTGGCCCCAGCAAGTCTGGCTCTGCTGGGCCTTTGTAGGTTGCCACGGGGCACCCCGGGCCTGTGGGACCAGTCACTTTCCTGGGCTCTCTCACCAGGGCCTAGGGTTGGCCACTTCTCATCCCCACATTGGCAGGTGTACCCCTGGGGAAGCCCAGGGGATTATGGGGATCTTACTCTGGGGTTTCCCAAGATGAAAACAAAAAATAGCAGCTAACACCATCAAGCTTCCATTGTGTGTGAAATGCTGTGCGAAGGGCTGGAACACATTCCATCGTCATTTAATCTTTCAACTGCCTCCTGCCATGAATCTACAATATAGTAATGACAGCAGCATTTATTGATAAACTAATAATAGCAGGGTTACCATGTGTTAGGCAGTCACTGTTGTAAGTAATTTACATGTATATTACATCATTTAACTTTCACAACAACCCTAAGATGTAGATACTATTATCATTCCCATTCTGGGAATGAGGAAATTGGGATTGACAGACCCCAGTTCAAATGCATCATCAATTTACCTGAGAAGTCCCTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCGGTGGCGTGATATTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCTGCCTCAGCCTCCCGTGTAGCTGGGACTACAGGTGCCCACCGCTACACCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCGCCTCGGCCTCCCAAAGTGCTGGGATAACAGGCATGAGCCACCGCACCCGGACTTTATTATTATTTTTTTAAAAGAGATTGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGTGCGAAGCGGGTACATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAAAAAATTAGCCAGGCGTCGTGGCACACGCCTGTAGTCCCAGCTGTGCAGGGGGCTGAGGCAAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGATATCACGCCACTGCACTCCAGCCTGAGTGACAGAGTGAGACTCTTGTCTCAAAAAAGTAAAATAATAAAATAAAAAAGAGAGACAGGGTCTTGCTCTGTTACCCAGGCTGAAGTGCTGTGGTGCCATCATAGTTCACTGCAGCCTCGAACTCTTGGATTCAAGCAATCCGCCTGCCTCAGCCTCCCTAGTAGCCAGGACCACAGGCATGAGCCACTGTCCCTGGCTAATTTCTTAATTTTTAAAATTTTTTGCAGAGACAGAGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGGCTCAAGCAATCCTCCCACTCTGGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGCGCCCACTGGAAGTCCCTCTTTGCATCTGCCTTCAATCCCCCTTGCTGTAGCTGGAGGCTTCCTTCTCATCCTGATCTCCAGAGTTAACCCAGACCTGCCACTAGTCCTGGCCCCCTTGGAGAGGGCAGACTGAATCCTTGCAAAGGTGACAAAAATGACCACTCGCTGATACTTCCTCTCCAGCCCAGTCTGCCTTGCCATATCAGTGCACTGAGTCATAACAAGAGGGCAGCCCAGTGCCTGCCTCAGTGTCTGGGTGCCCGAGCATGGCATGGTTTGCCCTTTCCCCGTAGGAAATGACCCTCCTGGTGCCCACCTGCCCACCCATTGCCTGGCTGGTTTGGCCACCTCGCGTCTGGAGGGACTTCTGCCCATTATGGAGAACTCTAGCCGTCATCTGAGCCTCTGGAGGGACAGACAGACAGACAGGACAGTACAGGGAGGTGGGAAACACGGAGAAGAAG
Task1_train_22476
Assess the clinical impact of this variant on gene SCNN1B (sodium channel epithelial 1 subunit beta), found on Chromosome 16. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
GAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCGCCACAATGCCCAACTAATTTTTGTATTTTTTTTTCTCTATTTTGATATGGAGTTTTGCTCTGTCGTCCTGGCTGCAGTGCAGTGGCGCAATCTCGGCTCACTACAACCTCTGTCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGTTGGGATTACAGGTGGCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTAGCCAGGTTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCGCTTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTGCCCGGCCAAGGAGCTCATGTTTAATGAGGCCCTTAGCACATCACCCCGCAGGTAGCAAGTGCTCAACTAGCCCTTATTGTCCTAACCAGAGGGACTCAACTCCACGTAGCTCAGGACCGTGGTGCGTGGGAGACTGGGTCCAGTCCCTTCCCTTGAGAACAGTCAAGAGGGGAAGGAAGACAGACAATAAAAGAGCAATCACACAAATGAGGCAGGTACTCAGAAGGAAAGTTCCGGGGCTAGGAAAGTGTACAACCAAGACCCTGACACCTCGTCTGAGCCATCAGAGAACGTTTCTGGAGGAAGTGATGCTGGTTGAGATCTGAGGGAAGAGCATGTGTTTCTAGGGGAAGGGAAGGGGCAGAGACAGCATTCCAGAGCTAGGGAATAGCACTCCAGATTGAGGAACAGCATTCCAGGTGAGAGAACAGAATTCCAGAGCAAGGAACAGCACTCCAGGTGAGGGAACAGCACTCCAGAGTGAGGAACAGCATTCCAGAGTGAGGGAACAGCATTTGCAAAGGCATAGCAGGAGGAAGGCGTGCAGAAGCTCGGAGGCATTGAACGGGGACAGCGAGGGCACCTGTGGTGTGAGGTGGGGTGGCATGGGTGGGCCGTGGCCATGCTATGCCTCCTTGATCTACCTCCTGATCAGAAAAGAGATCACGGGAGGCAAGAGACACCTAGGGAGGAGGCTACGTAAGAGCCTGCCTTAGAGATGATGGGGGCTTTGCAGAAGGCAAGCAGTATTTGAGGACTGAGTTTTTGCAAAGTGGAGCCAGCCTCCTTGGCGGTCCCTGGAGGTCCCCTGGCCGGAGGGAGCTTGGAGAAGTGGGTAGTGGGGTCTCCTTTCTGCCTCAGGAGAAAGTTCAGGCAGCCCTCACCCCACCCTCCCCACAGGCCTGAAGTTGATCCTGGACATAGGCCAGGAAGACTACGTCCCCTTCCTTGCGTCCACGGCCGGGGTCAGGCTGATGCTTCACGAGCAGAGGTCATACCCCTTCATCAGAGATGAGGGCATCTACGCCATGTCGGGGACAGAGACGTCCATCGGGGTACTCGTGGTATGGCCGGAGCCCAAGGGCAGTCCTAGAGGGTCTGAGGGTGGGAGCCCACCTGTCCAGGGCCAACTGCCCTTGGCCTGGGAGGAGGGGATCTGGGCCCCCCAGCCCTGGCCTTCCTTCCTTTTGGCTGGAATCCCCCCAGGGTGGCCCAAGCTTTAGGGGAAGGTGAGCCCTCTGGCGCCCCCTCTGGCGCCCCCCCTGGCACCTGCAGGGGTCCACAGCCCTCTGTCCCCAAATGCTTGATAGAAGGGAGGTGCAGAAAGGGCTTCCTGGGGTGACCAGTGTCCCCCTCAAGCAACCCCTCTAAACACAGGACAAGCTTCAGCGCATGGGGGAGCCCTACAGCCCGTGCACCGTGAATGGTTCTGAGGTCCCCGTCCAAAACTTCTACAGTGACTACAACACGACCTACTCCATCCAGGTGGGAAGGTGGTGCACGCCTCATGCCCCGGGGCCCCTGTCCGGGTTTATGGGGCCAAGGCCTCAGTACTCCGGGAGAGCTGGCCCCAGCAAGTCTGGCTCTGCTGGGCCTTTGTAGGTTGCCACGGGGCACCCCGGGCCTGTGGGACCAGTCACTTTCCTGGGCTCTCTCACCAGGGCCTAGGGTTGGCCACTTCTCATCCCCACATTGGCAGGTGTACCCCTGGGGAAGCCCAGGGGATTATGGGGATCTTACTCTGGGGTTTCCCAAGATGAAAACAAAAAATAGCAGCTAACACCATCAAGCTTCCATTGTGTGTGAAATGCTGTGCGAAGGGCTGGAACACATTCCATCGTCATTTAATCTTTCAACTGCCTCCTGCCATGAATCTACAATATAGTAATGACAGCAGCATTTATTGATAAACTAATAATAGCAGGGTTACCATGTGTTAGGCAGTCACTGTTGTAAGTAATTTACATGTATATTACATCATTTAACTTTCACAACAACCCTAAGATGTAGATACTATTATCATTCCCATTCTGGGAATGAGGAAATTGGGATTGACAGACCCCAGTTCAAATGCATCATCAATTTACCTGAGAAGTCCCTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCGGTGGCGTGATATTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCTGCCTCAGCCTCCCGTGTAGCTGGGACTACAGGTGCCCACCGCTACACCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCGCCTCGGCCTCCCAAAGTGCTGGGATAACAGGCATGAGCCACCGCACCCGGACTTTATTATTATTTTTTTAAAAGAGATTGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGTGCGAAGCGGGTACATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAAAAAATTAGCCAGGCGTCGTGGCACACGCCTGTAGTCCCAGCTGTGCAGGGGGCTGAGGCAAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGATATCACGCCACTGCACTCCAGCCTGAGTGACAGAGTGAGACTCTTGTCTCAAAAAAGTAAAATAATAAAATAAAAAAGAGAGACAGGGTCTTGCTCTGTTACCCAGGCTGAAGTGCTGTGGTGCCATCATAGTTCACTGCAGCCTCGAACTCTTGGATTCAAGCAATCCGCCTGCCTCAGCCTCCCTAGTAGCCAGGACCACAGGCATGAGCCACTGTCCCTGGCTAATTTCTTAATTTTTAAAATTTTTTGCAGAGACAGAGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGGCTCAAGCAATCCTCCCACTCTGGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGCGCCCACTGGAAGTCCCTCTTTGCATCTGCCTTCAATCCCCCTTGCTGTAGCTGGAGGCTTCCTTCTCATCCTGATCTCCAGAGTTAACCCAGACCTGCCACTAGTCCTGGCCCCCTTGGAGAGGGCAGACTGAATCCTTGCAAAGGTGACAAAAATGACCACTCGCTGATACTTCCTCTCCAGCCCAGTCTGCCTTGCCATATCAGTGCACTGAGTCATAACAAGAGGGCAGCCCAGTGCCTGCCTCAGTGTCTGGGTGCCCGAGCATGGCATGGTTTGCCCTTTCCCCGTAGGAAATGACCCTCCTGGTGCCCACCTGCCCACCCATTGCCTGGCTGGTTTGGCCACCTCGCGTCTGGAGGGACTTCTGCCCATTATGGAGAACTCTAGCCGTCATCTGAGCCTCTGGAGGGACAGACAGACAGACAGGACAGTACAGGGAGGTGGGAAACACGGAGAAGAAG
GAAGCCCAGCAAAAGCACTTCCTCACTGGAAGACCTCAGACAAGTCCCTTCACTTCTCTGTGCCTCAGTTTCTCCATCTGTAAAATGGGGACAATACTAGTACCTCCATCATGCAGCCCTTGTGAGCATCCGAGGAGCTCATGTTTATTTTATTTTATTTTTGGAGATGGAGTCTCACTCTCGCTCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCGCCACAATGCCCAACTAATTTTTGTATTTTTTTTTCTCTATTTTGATATGGAGTTTTGCTCTGTCGTCCTGGCTGCAGTGCAGTGGCGCAATCTCGGCTCACTACAACCTCTGTCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGTTGGGATTACAGGTGGCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTAGCCAGGTTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCGCTTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTGCCCGGCCAAGGAGCTCATGTTTAATGAGGCCCTTAGCACATCACCCCGCAGGTAGCAAGTGCTCAACTAGCCCTTATTGTCCTAACCAGAGGGACTCAACTCCACGTAGCTCAGGACCGTGGTGCGTGGGAGACTGGGTCCAGTCCCTTCCCTTGAGAACAGTCAAGAGGGGAAGGAAGACAGACAATAAAAGAGCAATCACACAAATGAGGCAGGTACTCAGAAGGAAAGTTCCGGGGCTAGGAAAGTGTACAACCAAGACCCTGACACCTCGTCTGAGCCATCAGAGAACGTTTCTGGAGGAAGTGATGCTGGTTGAGATCTGAGGGAAGAGCATGTGTTTCTAGGGGAAGGGAAGGGGCAGAGACAGCATTCCAGAGCTAGGGAATAGCACTCCAGATTGAGGAACAGCATTCCAGGTGAGAGAACAGAATTCCAGAGCAAGGAACAGCACTCCAGGTGAGGGAACAGCACTCCAGAGTGAGGAACAGCATTCCAGAGTGAGGGAACAGCATTTGCAAAGGCATAGCAGGAGGAAGGCGTGCAGAAGCTCGGAGGCATTGAACGGGGACAGCGAGGGCACCTGTGGTGTGAGGTGGGGTGGCATGGGTGGGCCGTGGCCATGCTATGCCTCCTTGATCTACCTCCTGATCAGAAAAGAGATCACGGGAGGCAAGAGACACCTAGGGAGGAGGCTACGTAAGAGCCTGCCTTAGAGATGATGGGGGCTTTGCAGAAGGCAAGCAGTATTTGAGGACTGAGTTTTTGCAAAGTGGAGCCAGCCTCCTTGGCGGTCCCTGGAGGTCCCCTGGCCGGAGGGAGCTTGGAGAAGTGGGTAGTGGGGTCTCCTTTCTGCCTCAGGAGAAAGTTCAGGCAGCCCTCACCCCACCCTCCCCACAGGCCTGAAGTTGATCCTGGACATAGGCCAGGAAGACTACGTCCCCTTCCTTGCGTCCACGGCCGGGGTCAGGCTGATGCTTCACGAGCAGAGGTCATACCCCTTCATCAGAGATGAGGGCATCTACGCCATGTCGGGGACAGAGACGTCCATCGGGGTACTCGTGGTATGGCCGGAGCCCAAGGGCAGTCCTAGAGGGTCTGAGGGTGGGAGCCCACCTGTCCAGGGCCAACTGCCCTTGGCCTGGGAGGAGGGGATCTGGGCCCCCCAGCCCTGGCCTTCCTTCCTTTTGGCTGGAATCCCCCCAGGGTGGCCCAAGCTTTAGGGGAAGGTGAGCCCTCTGGCGCCCCCTCTGGCGCCCCCCCTGGCACCTGCAGGGGTCCACAGCCCTCTGTCCCCAAATGCTTGATAGAAGGGAGGTGCAGAAAGGGCTTCCTGGGGTGACCAGTGTCCCCCTCAAGCAACCCCTCTAAACACAGGACAAGCTTCAGCGCATGGGGGAGCCCTACAGCCCGTGCACCGTGAATGGTTCTGAGGTCACCGTCCAAAACTTCTACAGTGACTACAACACGACCTACTCCATCCAGGTGGGAAGGTGGTGCACGCCTCATGCCCCGGGGCCCCTGTCCGGGTTTATGGGGCCAAGGCCTCAGTACTCCGGGAGAGCTGGCCCCAGCAAGTCTGGCTCTGCTGGGCCTTTGTAGGTTGCCACGGGGCACCCCGGGCCTGTGGGACCAGTCACTTTCCTGGGCTCTCTCACCAGGGCCTAGGGTTGGCCACTTCTCATCCCCACATTGGCAGGTGTACCCCTGGGGAAGCCCAGGGGATTATGGGGATCTTACTCTGGGGTTTCCCAAGATGAAAACAAAAAATAGCAGCTAACACCATCAAGCTTCCATTGTGTGTGAAATGCTGTGCGAAGGGCTGGAACACATTCCATCGTCATTTAATCTTTCAACTGCCTCCTGCCATGAATCTACAATATAGTAATGACAGCAGCATTTATTGATAAACTAATAATAGCAGGGTTACCATGTGTTAGGCAGTCACTGTTGTAAGTAATTTACATGTATATTACATCATTTAACTTTCACAACAACCCTAAGATGTAGATACTATTATCATTCCCATTCTGGGAATGAGGAAATTGGGATTGACAGACCCCAGTTCAAATGCATCATCAATTTACCTGAGAAGTCCCTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCGGTGGCGTGATATTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCTGCCTCAGCCTCCCGTGTAGCTGGGACTACAGGTGCCCACCGCTACACCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCGCCTCGGCCTCCCAAAGTGCTGGGATAACAGGCATGAGCCACCGCACCCGGACTTTATTATTATTTTTTTAAAAGAGATTGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGTGCGAAGCGGGTACATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAAAAAATTAGCCAGGCGTCGTGGCACACGCCTGTAGTCCCAGCTGTGCAGGGGGCTGAGGCAAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGATATCACGCCACTGCACTCCAGCCTGAGTGACAGAGTGAGACTCTTGTCTCAAAAAAGTAAAATAATAAAATAAAAAAGAGAGACAGGGTCTTGCTCTGTTACCCAGGCTGAAGTGCTGTGGTGCCATCATAGTTCACTGCAGCCTCGAACTCTTGGATTCAAGCAATCCGCCTGCCTCAGCCTCCCTAGTAGCCAGGACCACAGGCATGAGCCACTGTCCCTGGCTAATTTCTTAATTTTTAAAATTTTTTGCAGAGACAGAGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGGCTCAAGCAATCCTCCCACTCTGGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGCGCCCACTGGAAGTCCCTCTTTGCATCTGCCTTCAATCCCCCTTGCTGTAGCTGGAGGCTTCCTTCTCATCCTGATCTCCAGAGTTAACCCAGACCTGCCACTAGTCCTGGCCCCCTTGGAGAGGGCAGACTGAATCCTTGCAAAGGTGACAAAAATGACCACTCGCTGATACTTCCTCTCCAGCCCAGTCTGCCTTGCCATATCAGTGCACTGAGTCATAACAAGAGGGCAGCCCAGTGCCTGCCTCAGTGTCTGGGTGCCCGAGCATGGCATGGTTTGCCCTTTCCCCGTAGGAAATGACCCTCCTGGTGCCCACCTGCCCACCCATTGCCTGGCTGGTTTGGCCACCTCGCGTCTGGAGGGACTTCTGCCCATTATGGAGAACTCTAGCCGTCATCTGAGCCTCTGGAGGGACAGACAGACAGACAGGACAGTACAGGGAGGTGGGAAACACGGAGAAGAAG
Task1_train_22477
The variant affects gene SCNN1B (sodium channel epithelial 1 subunit beta), which is on Chromosome 16. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
TGTGAGGACCAGAGGTGGGAGAGAGCCGGGCAGGGTGGCCAGGCCCGCCGAGGAAGAGTCTGGAGGCCCGAGTCCTTCCTCCCCTAGAACAGCAGCCACAGCTTCCACTACGACCTTCCTCCTGCTCCTCATCCAAATTGTGATTCCCCCGGGGGCCTCAGGAAGGGACAGGGCTGTGGTCTACCTCCCCCAGGGAACAGAGCCATGACTGGGAGGGATGCTGCAGATGGCAACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAG
TGTGAGGACCAGAGGTGGGAGAGAGCCGGGCAGGGTGGCCAGGCCCGCCGAGGAAGAGTCTGGAGGCCCGAGTCCTTCCTCCCCTAGAACAGCAGCCACAGCTTCCACTACGACCTTCCTCCTGCTCCTCATCCAAATTGTGATTCCCCCGGGGGCCTCAGGAAGGGACAGGGCTGTGGTCTACCTCCCCCAGGGAACAGAGCCATGACTGGGAGGGATGCTGCAGATGGCAACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCAAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAG
Task1_train_22478
Gene SCNN1B (sodium channel epithelial 1 subunit beta), found on Chromosome 16, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Liddle syndrome 1
ACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCAT
ACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCGGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCAT
Task1_train_22479
A change on Chromosome 16 affects gene SCNN1B (sodium channel epithelial 1 subunit beta). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Liddle syndrome 1
ACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCAT
ACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCTGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCAT
Task1_train_22480
The variant affects gene SCNN1B (sodium channel epithelial 1 subunit beta), which is on Chromosome 16. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
ACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCAT
ACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCTGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCAT
Task1_train_22481
This alteration occurs within gene SCNN1B (sodium channel epithelial 1 subunit beta) located on Chromosome 16. Is it associated with a disease or is it a benign variant?
Pathogenic; Pseudohypoaldosteronism, type IB2, autosomal recessive
ACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCAT
ACTTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCTGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCAT
Task1_train_22482
Consider this mutation in SCNN1B (sodium channel epithelial 1 subunit beta) on Chromosome 16. Is this a benign change or a disease-causing variant?
Pathogenic; Liddle syndrome 1
TTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTT
TTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGTCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTT
Task1_train_22483
A sequence alteration has been identified in SCNN1B (sodium channel epithelial 1 subunit beta) on Chromosome 16. Is it disease-inducing or harmless?
Pathogenic; Pseudohypoaldosteronism, type IB2, autosomal recessive
TTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTT
TTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGTCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTT
Task1_train_22484
A mutation found in SCNN1B (sodium channel epithelial 1 subunit beta) on Chromosome 16 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
TTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTT
TTTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGTCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTT
Task1_train_22485
A variant was discovered in gene SCNN1B (sodium channel epithelial 1 subunit beta), Chromosome 16. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Liddle syndrome 1
TTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTG
TTTGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCTCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTG
Task1_train_22486
This mutation is located in gene SCNN1B (sodium channel epithelial 1 subunit beta) on Chromosome 16. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Pseudohypoaldosteronism, type IB2, autosomal recessive
TGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTGTT
TGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCTCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTGTT
Task1_train_22487
This is a variant in SCNN1B (sodium channel epithelial 1 subunit beta), located on Chromosome 16. Is this mutation a likely cause of disease or not?
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
TGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTGTT
TGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCTCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTGTT
Task1_train_22488
Mutation context: Chromosome 16, Gene SCNN1B (sodium channel epithelial 1 subunit beta). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Liddle syndrome 1
TGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTGTT
TGCAACCACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCTCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTGTT
Task1_train_22489
This mutation is located in gene SCNN1B (sodium channel epithelial 1 subunit beta) on Chromosome 16. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Liddle syndrome 1
CACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACTATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTGTTGTTATT
CACCTTCTTGGGTTCCAGGACTGGATTTTCCACGTCTTGTCTCAGGAGCGGGACCAAAGCACCAATATCACCCTGAGCAGGTGAGCCTGAGCCTGGGCGGGGCTGGGGAAGACAGGGAAGGGGTCCAGAAACTCGGGGCAGGAGTTTGGACACAGGACAGCTCCTCAGACACATTCTCACATGGGTCAGACCGAGGAGCAAGTCTTGAGGAGGAGGCACTAGGAGTGAGAGAGAGGAAAGGCAGCCAAGGGGACTCTGAGTCTACCACCTGCTAAGGAGAAGCCTGTGCTTCCCTCTGTCACTGTGCATCCAACCAGCCATCCATTCATCCTCCATCATCCACCCACGCGCCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCCACACACCCAGCCATCCTCCACTCATTCATCCTCCATTCTCCCACCCACGCAGCCAGCCATCCTCCACCCATTCATCCCTCCATCATCCACCTCTCCATTCTCCCACCCACGCACCCAGCCATCCTCCGTTTATTCATGGATCTCTCCATCCATTCAACACAAACACTAGTTGAGCACAAGAAAGACACACAGTCCAAGCTAGCAGGAGTCTAGGGGGCAAACATATGTAAAAAGGGCTCAAGGAGAGGAGGGTCTGTACAAGCCCCCTACTCTAGGAGTACAGCAGGGAAGGAGCCTCAGTCTGCCTGAGAGATAAGGGAGGTCTGCGTAGGGAGGTGGCTTTGAGTGAACTCTCCAAGGAGGAGTAAGTGCTGTTCAGATAAGAAGAGGTACCAATGTCCAGGCAGAAGACAAAGCTGGAAAGCCTGGAGGCACGAGACAGCACAGCCTGAGGACGATCAGGTGGGAGGGGATGCCCACACAGCCACCCTTCTCTGTCCCAGGTGCAGTGAAGGCGCTCAAGGCTCAGTGAAGAGCTCTGTGCGGAGTCACTCCGTATAGCCCAGGCCACCCTGATGGCACAAAGTGGGGAGCTCAGAGCAGATCTTTGGGGCTGTCCCAGGCCAGAGTGTCCTGTAGGGAACTGGTAGTCAGGGGATGGAGAAAGGGGGCCATAGGATGGGTGCTGGGCAGAGATGCCCAGAAGGGCCGGGAAGGGCTGCACTTGCAGTTCTCGTTTGGACCTCCCCACTCACGGGGGCACGCATGAGAGAAGCTCAGGACAGAGGAGGGCTGGGGCGGCCATCCCTGGCTGCCTTCCTGTGTGCATGTGTGCACGGGTGTGTGGGTACATGTGTGTGCATACATGTGGGTGTGTGCACGTGCATGTGTGTGCATGTGTCTATGTGCGTGTGTGTGTGTCTGTCTGTTTGGAAGGGGGATACATTAGTCCCGGCCCTTCTCGCTGCCTCCTGCAGGAAGGGAATTGTCAAGCTCAACATCTACTTCCAAGAATTTAACTATCGCACCATTGAAGAATCAGCAGCCAATAACGTGAGTTTAGGAGTCTCCCAATACCCCAGCCCTGCCCTGCCCTGACCCCTGCACCCTGAGGGTGGGGGAAGGGTTCTGAGCCCTATGAAGGAATTAGGAAGATCCCTAAGACAGTCCCAAGTTATTCCCCTGGGCCAAGATGGTCACCCCCTCCCGTTCCCACCCAAGAATCACCTCCCAGGAAGCTGTGAGGCTGGGCTAGAGGCAAGAATGTGTGGCCTGAGCTCACCCCAGCTCCCTGTTCCCCACAGATCGTCTGGCTGCTCTCGAATCTGGGTGGCCAGTTTGGCTTCTGGATGGGGGGCTCTGTGCTGTGCCTCATCGAGTTTGGGGAGATCATCATCGACTTTGTGTGGATCACCATCATCAAGCTGGTGGCCTTGGCCAAGAGCCTACGGCAGCGGCGAGCCCAAGCCAGCTACGCTGGCCCACCGCCCACCGTGGCCGAGCTGGTGGAGGCCCACACCAACTTTGGCTTCCAGCCTGACACGGCCCCCCGCAGCCCCAACACTGGGCCCTACCCCAGTGAGCAGGCCCTGCCCATCCCAGGCACCCCGCCCCCCAACCATGACTCCCTGCGTCTGCAGCCGCTGGACGTCATCGAGTCTGACAGTGAGGGTGATGCCATCTAACCCTGCCCCTGCCCACCCCGGGCGGCTGAAACTCACTGAGCAGCCAAGACTGTTGCCCGAGGCCTCACTGTATGGTGCCCTCTCCAAAGGGTCGGGAGGGTAGCTCTCCAGGCCAGAGCTTGTGTCCTTCAACAGAGAGGCCAGCGGCAACTGGTCCGTTACTGGCCAAGGGCTCTGTAGAATCACGGTGCTGGTACAGGATGCAGGAATAAATTGTATCTTCACCTGGTTCCTACCCTCGTCCCTACCTGTCCTGATCCTGGTCCTGAAGACCCCTCGGAACACCCTCTCCTGGTGGCAGGCCACTTCCCTCCCAGTGCCAGTCTCCATCCACCCCAGAGAGGAACAGGCGGGTGGGCCATGTGGTTTTCTCCTTCCTGGCCTTGGCTGGCCTCTGGGGCAGGGGTGGTGGAGAGATGGAAGGGCATCAGGTGTAGGGACCCTGCCAAGTGGCACCTGATTTACTCTAGAAAATAAAAGTAGAAAATACTGAGTCCAGCTGTGTTGTTTGTTTGACTGGGCAGCCGAGGTGCCCTGATGGCGGAAGGGCATCCATAGTGGCTTGAGACCCAAACTGGTTTAAGGGAAAGGCTCTCAAGCCCCTCCTTCCACTGCCAGCTCCCAGGCTGACACTCACTGATCCCTGCCTGGGTTGTGTACCCATCTCTGACCCAGTCAGTGTGGCCAGTTAGATAAGCTGCTCTGACTGGTCACACCTGAATTCATCTGCCCAGACCTGAAGCCAGTTTGGCCCCCAGGAGAATCACATGGTCCAAGGGCGGTGGGGGCACAGTACCCACGGTTGCCAGATAACAATCAGGCTGCTTGGTTGAATTTGAATTTCAGATAGACAAACTGATTTTTTTTTTTTTTGAGATGGAGTCTCACTGTCATTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGTGATTCTCATGCCTTGGCCTCGCGAGTAGCTGGAATTACAGGTGCATGCCACCACGCCCAGCTAATTTTCATATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCGGGCTGGTCTCAAGCTCCTGGCCTCAGGCGATCCACCTGCCTCAGCCTCTCAAAGTGGTGGGATTACAGGCATGAGTCACCGACCCCAGCCGAAAAACTGATTTTTTTAGTATATGTACATCCATGCAATACTAGAGACACATACAAATAAATCATTTGTTGTTTTTTTTGAGCATTTTATACATATATATTTTTATAGAGATGGGGTGTCACTGTGTTGCCCAGGTGGGAGTGCAATGGCATGATCATAGCTCACCGTAGCCTCAAACTCCTGGGCTCAAGCCATCCTCCCACTTCAGCCTCCCAAGCAGCTGGAATTACAGGTGTGCACTACCATGCCTGGCTAATTTTTTTTAATTAAAATTTAATTTTAATTTTTTTCATTCTGTATTTTTAATTGCTAAATACCGTCCCCCAAAAGCTTAAGGTACCCAAAGAGAGATCAGGGAGCTGTCACCAGAGTACGGTCTGGCAGGTGCACACACAGCACTGCAGCACCCTGCTGTCACCTACCGGGCCCCTGGTGATGAAGGAGAGGCTGGCTTAGAGCCTGAGCCTCTGAGGGCCCAGCCTTCCTGGCCTAGGTCACCTGTGTCCCTTGGTCTGGAAGGTAAACAAGCTGGCCTCCCATCAAGTGCTCAGGATGGCACCTGTGGAAGAAGGAGGTGCCACAGAGTCGGTGCCACTTCAGTCAAAGGCAACGTTGCTAGGGGCTGAGTAGGGAGGGCTGAGTAGGAAACCGGGTTTCCCAGCTTGGGGCCTGGCTAGCTCGCAGGCTGGGCCCACAACTCTTGGTGGTTACCACCCTTACTACTTACTGTGTGATTACCGCTGTGATTACTTACTACTGTGATTACCGCTTTTATTACTAGCAGTAGTAGTTGTGGCCACAATCACTGTTACCATTTGTTGTTATT
Task1_train_22490
Chromosome 16 houses a mutation in gene COG7, LOC130058658 (component of oligomeric golgi complex 7| ATAC-STARR-seq lymphoblastoid active region 10580). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; COG7 congenital disorder of glycosylation
CACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGATCAGCCTGGCCAACATCATGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGGGTGGGGCACGCACCTGTAATCCCAGCTACTCAGGAGGTAGAGGCAGGAGAATAACTTGAACTCAGAAGGGGGAGGTTGCAGTGAGCTGAGATGGCGCCACTGCACTCCAGCCAGGGGGAAAGAGCGAGACTTCGTCTCAAAAAAAACAAAAAAACAAACAAAAATGGGAACATCTCTTGGACTATCCACTCCCAGTGGAAGCAGTCTGTTTGGTCTTTCCATCTGAGCCTAGGAGAGAGACTTGTGTGCAGTACGTACTGAATCAACACACAGTGAATCAACACACGGTGAATAAAAGTCAAGTTGAGGAGTTACATGAAATGGTTGCCAGTGCATGTTATTTTTTATAATTTAACTTATCCTCAACAAATGGTTTAGGCCAGGCGTGGTGGCTCACACCAGTAATCCTAGGGCTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGTCAGAAATTTGAGATCAACCTGGGCAACATAGTGCGACCTTGTCTCTAAAAAAAAATTTTTTTTTTTAATTAGCCAGGCATGGTGGCACATGCCTATAGTTCCAGTTACTTGGGAGGCTGAGGCGAGCGGACTGCTTGAACCCAGAGTTTGAGGCTGCAGTGAACTATGATGGTATCACTGCATTCCAGCTTGGGCAGCAGAATGAGGAATGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAGGTTTAAGTCTCCACTGAGACCAGCCTATCTTCCTCAGCTGAAATAAAATCCACTAAAACAATGTTTTCTAGATCTGTGTCATTCTCTTATACCTATACTATAATACGTTTTTTCCAGATATATGGATCTGTTGGCTATTCTTTCATACTCTCAAAATTCACTTTTTTTTTCTTTTTACAGTTTATTGTTTGGTACAAAACAGGCTCTTTAACTCTTTGAATAAACACCTCACAGACTCGTGCTCCTAGATTACAAAAAGTCAAAGCCAATTTTCTTTGACACTGGGCTCTTGACTCTGAGATTCAAGTCACTATAACAGAAACTGGAGTTGTTTTATCTTATATTCTGGAAGGTGCCTCAACAAAGACATGTTAAGAACTGGTTAAAACTTCTAGCATTTAAAAAGATCCATCTTGTCTTCCAGTGCCTATGGATAATAATAAAAAGGGAATCCCAGAGATCTGCTATTGAATTATTTAGAGAAGAGCTACTGCAATAAGATCCACTCTTTTAAGTTCCAAAAGGAAACTTCAGGCCAGATGTGGTGGCTCACAGGTATAATCACAGTACTTTGGGAGGCCAAGACTGGAAAACCCATTATGCCCAGGAATTTGAATTTGAGACCAGCCTGGCAACACAGTGAGATCCCATCTCTACAATTTTTTTTTTAAACAGAATTTGTGGGGCGCGGTGGCTCGCGCCTGTAGTCCTAGCGACTCGAGAGGCGAGAGGATCGCTTGAGTGCAGGAGTTCGAGGCTGCAGTGAGCTATGATCGAGCCACTGTAGAGAGACCCTGTTTCAAAAGAAAAAACAAAGAGAAAGAAAGAAAAGAAAAAGGAAACTTATAGCCCAGCCAGAGGAGGAAAAACAACACCCAAAATTAGCAAGTGTTCAAGACAGCCCGGCACCCAGCTGAGACTCCCGCTGACGTGATCAGGAGTTCGGGGCTTGCTCTTTTGCCGAGGGTATTTGCTGTCCATGCGTGCCCCGCCCACCTGAGTGCCTCACGCAAGTTCGGTGACCTCTGCCCAGCCGAGAGCAGGGGAGGGTCCCGCGGCCAGGGCCCCGAGCGGCTCACCCTCCACGGCGTGGTTCACCTCTTGGATGAACAGCTGCAGCTTCATCACCAGGGTGGCTGCGTGGCCATCCGCCTTCCCGGACGCCGCCTCCTTGGAGCCGGCCCTGAAGGCCGCATTGATCCACTCCTTCACGTCGAAGTCGTCTGCCAGGAACTTGGAGAAGTCCATGGCGGAACTGCCTCAGGCCTGGCGTCCAGAACTTAAGAGTTGGCTCCGGGCGGCAACGGGGATGCAGAAGCGAGCGAGCCTGCGAGAGCACCGAGGCTAGCCTCCGAGGCGAACCCCAGAAACGCCAGGACGGGTAACTTGCCCCTTTGCGCTTCCCCGCTCAGCGCACTCAGTTTGCGGCTGGGAATGACCCTCGCCGCCCGCCGTTCTTCTTCCGGAAGTCGTTGGCCGTTACCATAGTGACTGCAGGCGTCCGGAGCGCTGAGCAGAGGTGGGTGTGGGAAAACGCCCCGGACTGAGAGCTCCCGGCACCGACAAATATCCCATGTCTGCTAACATTTGCCGAGGACTAAACTATATGCTTACTATAAAGCCCTGACATACATTAGCGCATTTACGCGGTGGCTCGCGCCTGTAATCCCAGCTCTTTAGGAAGCTGACGCGGGAGAATCGCTTGAGGCCAGGAGTTCTAGGACAGCCTGGGCAACAGTGGAGCGCAGTGGGCAGCAATGGAGTGCAATTGAACGATCTCTGCTCACTACAGCCTCAAATTCCTGGGCAATTGAACGATCTCAGCTCACTGCAGCCTCAAATTTCTGGGCTCCAGCGATCCTCCCACCTCAGCCTCCAGAGTAGCTGGGACTACAGGCGCGCGACAACACGCCCGGCTATTTCTTTCTTTTTCTTTCTTTCTTTATTTTTTTCTGAGACGGAGTCTTGCTCTGTCGCCCAGGTTGGAGCGAAGTGACGCGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGAGTGTCTTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCGTGCCACCACGCCCGGCTACTTTTTGTATTATTAGTAGAGATGGGGTTTCACCACGCTGGCCAGGCTGGCCTCAAACTCCCAACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGTTGGGATCACAGGCGTGAGTCACCGCGCCTGGCCTAACTAATTATTTTCTTAATGATGTGTTTTGAGGTGCAGACCTTTTAAAGTTTGTTAAGTTCCTTATCACCTTTTTTTATGGATCATGCTTTTGGTGTTGCGGCTGAGAAATCTGTGCATAACCCATAATCACAAACAATTTCTCAGCCTGGGCAACATAGGAAGACCCCGTCTCTGCAAAAAAATTAAAAATTAGCTGAGTGTGGTGGCGCACACCTGTAGTCTCAGCTACTCGAGAGGCTGGGGTGAGAGGATTGCCTGAGCCCAGGAGGTCGAGGCTGCAGTGAGCTGTGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACCCTGTCTCGAAAAGAAAAGAAGAAAAGGTAGGGGAAGGTATGAGGGTATTCTTTAGGTTCTAAGTTTTTATGTTGTTTCAAGAGTGGGACCAACCCAAGGGGGAGGACAAGATGTCATCCTTGGAAACCCTACAGGGGACAGTTTTCCAGGTTGGCCTGCCATTGGGGTATGAGTGGCTGGCTGCCATCTCCAGGCCTGATAGTCACTCGTTTTTCATTGGCATCTCCCTTGGTTTGTCTCATTCTTCTGGGTTGAGTAGGTTTTAACTGGGGTAACCCTTCTGCTAGGAGTCCCAGTTATTTGGGGGGAGGGGAGAGGAGGGAAGGAGAGAGGAGGGGAGCAATGCAGGGAGGGGAGACGAGGGGAGCAATCTGATAGTGTAAGTCCTCTTACTTTGCTCTTGTTAAAAATTTAGGCAGGACACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATGATGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTCAAACCCCATCTCTACTAATAATAAAAAAATTAGCTGGGCATGGTGGCACGCGCCTGTAATCCCAGCCACTCAGGAGGCAGAGGCAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAACCGAGATCCGCCACTGCACTCCAGCCTGGGCAACAGACCGAGACTCCATCCCCCCCAAAAAAAAAAAAAATCCTGCTGGGATTT
CACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGATCAGCCTGGCCAACATCATGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGGGTGGGGCACGCACCTGTAATCCCAGCTACTCAGGAGGTAGAGGCAGGAGAATAACTTGAACTCAGAAGGGGGAGGTTGCAGTGAGCTGAGATGGCGCCACTGCACTCCAGCCAGGGGGAAAGAGCGAGACTTCGTCTCAAAAAAAACAAAAAAACAAACAAAAATGGGAACATCTCTTGGACTATCCACTCCCAGTGGAAGCAGTCTGTTTGGTCTTTCCATCTGAGCCTAGGAGAGAGACTTGTGTGCAGTACGTACTGAATCAACACACAGTGAATCAACACACGGTGAATAAAAGTCAAGTTGAGGAGTTACATGAAATGGTTGCCAGTGCATGTTATTTTTTATAATTTAACTTATCCTCAACAAATGGTTTAGGCCAGGCGTGGTGGCTCACACCAGTAATCCTAGGGCTTTGGGAAGCCAAGATGGGAGGATCACTTGAGGTCAGAAATTTGAGATCAACCTGGGCAACATAGTGCGACCTTGTCTCTAAAAAAAAATTTTTTTTTTTAATTAGCCAGGCATGGTGGCACATGCCTATAGTTCCAGTTACTTGGGAGGCTGAGGCGAGCGGACTGCTTGAACCCAGAGTTTGAGGCTGCAGTGAACTATGATGGTATCACTGCATTCCAGCTTGGGCAGCAGAATGAGGAATGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAGGTTTAAGTCTCCACTGAGACCAGCCTATCTTCCTCAGCTGAAATAAAATCCACTAAAACAATGTTTTCTAGATCTGTGTCATTCTCTTATACCTATACTATAATACGTTTTTTCCAGATATATGGATCTGTTGGCTATTCTTTCATACTCTCAAAATTCACTTTTTTTTTCTTTTTACAGTTTATTGTTTGGTACAAAACAGGCTCTTTAACTCTTTGAATAAACACCTCACAGACTCGTGCTCCTAGATTACAAAAAGTCAAAGCCAATTTTCTTTGACACTGGGCTCTTGACTCTGAGATTCAAGTCACTATAACAGAAACTGGAGTTGTTTTATCTTATATTCTGGAAGGTGCCTCAACAAAGACATGTTAAGAACTGGTTAAAACTTCTAGCATTTAAAAAGATCCATCTTGTCTTCCAGTGCCTATGGATAATAATAAAAAGGGAATCCCAGAGATCTGCTATTGAATTATTTAGAGAAGAGCTACTGCAATAAGATCCACTCTTTTAAGTTCCAAAAGGAAACTTCAGGCCAGATGTGGTGGCTCACAGGTATAATCACAGTACTTTGGGAGGCCAAGACTGGAAAACCCATTATGCCCAGGAATTTGAATTTGAGACCAGCCTGGCAACACAGTGAGATCCCATCTCTACAATTTTTTTTTTAAACAGAATTTGTGGGGCGCGGTGGCTCGCGCCTGTAGTCCTAGCGACTCGAGAGGCGAGAGGATCGCTTGAGTGCAGGAGTTCGAGGCTGCAGTGAGCTATGATCGAGCCACTGTAGAGAGACCCTGTTTCAAAAGAAAAAACAAAGAGAAAGAAAGAAAAGAAAAAGGAAACTTATAGCCCAGCCAGAGGAGGAAAAACAACACCCAAAATTAGCAAGTGTTCAAGACAGCCCGGCACCCAGCTGAGACTCCCGCTGACGTGATCAGGAGTTCGGGGCTTGCTCTTTTGCCGAGGGTATTTGCTGTCCATGCGTGCCCCGCCCACCTGAGTGCCTCACGCAAGTTCGGTGACCTCTGCCCAGCCGAGAGCAGGGGAGGGTCCCGCGGCCAGGGCCCCGAGCGGCTCACCCTCCACGGCGTGGTTCACCTCTTGGATGAACAGCTGCAGCTTCATCACCAGGGTGGCTGCGTGGCCATCCGCCTTCCCGGACGCCGCCTCCTTGGAGCCGGCCCTGAAGGCCGCATTGATCCACTCCTTCACGTCGAAGTCGTCTGCCAGGAACTTGGAGAAGTCCACGGCGGAACTGCCTCAGGCCTGGCGTCCAGAACTTAAGAGTTGGCTCCGGGCGGCAACGGGGATGCAGAAGCGAGCGAGCCTGCGAGAGCACCGAGGCTAGCCTCCGAGGCGAACCCCAGAAACGCCAGGACGGGTAACTTGCCCCTTTGCGCTTCCCCGCTCAGCGCACTCAGTTTGCGGCTGGGAATGACCCTCGCCGCCCGCCGTTCTTCTTCCGGAAGTCGTTGGCCGTTACCATAGTGACTGCAGGCGTCCGGAGCGCTGAGCAGAGGTGGGTGTGGGAAAACGCCCCGGACTGAGAGCTCCCGGCACCGACAAATATCCCATGTCTGCTAACATTTGCCGAGGACTAAACTATATGCTTACTATAAAGCCCTGACATACATTAGCGCATTTACGCGGTGGCTCGCGCCTGTAATCCCAGCTCTTTAGGAAGCTGACGCGGGAGAATCGCTTGAGGCCAGGAGTTCTAGGACAGCCTGGGCAACAGTGGAGCGCAGTGGGCAGCAATGGAGTGCAATTGAACGATCTCTGCTCACTACAGCCTCAAATTCCTGGGCAATTGAACGATCTCAGCTCACTGCAGCCTCAAATTTCTGGGCTCCAGCGATCCTCCCACCTCAGCCTCCAGAGTAGCTGGGACTACAGGCGCGCGACAACACGCCCGGCTATTTCTTTCTTTTTCTTTCTTTCTTTATTTTTTTCTGAGACGGAGTCTTGCTCTGTCGCCCAGGTTGGAGCGAAGTGACGCGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGAGTGTCTTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCGTGCCACCACGCCCGGCTACTTTTTGTATTATTAGTAGAGATGGGGTTTCACCACGCTGGCCAGGCTGGCCTCAAACTCCCAACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGTTGGGATCACAGGCGTGAGTCACCGCGCCTGGCCTAACTAATTATTTTCTTAATGATGTGTTTTGAGGTGCAGACCTTTTAAAGTTTGTTAAGTTCCTTATCACCTTTTTTTATGGATCATGCTTTTGGTGTTGCGGCTGAGAAATCTGTGCATAACCCATAATCACAAACAATTTCTCAGCCTGGGCAACATAGGAAGACCCCGTCTCTGCAAAAAAATTAAAAATTAGCTGAGTGTGGTGGCGCACACCTGTAGTCTCAGCTACTCGAGAGGCTGGGGTGAGAGGATTGCCTGAGCCCAGGAGGTCGAGGCTGCAGTGAGCTGTGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACCCTGTCTCGAAAAGAAAAGAAGAAAAGGTAGGGGAAGGTATGAGGGTATTCTTTAGGTTCTAAGTTTTTATGTTGTTTCAAGAGTGGGACCAACCCAAGGGGGAGGACAAGATGTCATCCTTGGAAACCCTACAGGGGACAGTTTTCCAGGTTGGCCTGCCATTGGGGTATGAGTGGCTGGCTGCCATCTCCAGGCCTGATAGTCACTCGTTTTTCATTGGCATCTCCCTTGGTTTGTCTCATTCTTCTGGGTTGAGTAGGTTTTAACTGGGGTAACCCTTCTGCTAGGAGTCCCAGTTATTTGGGGGGAGGGGAGAGGAGGGAAGGAGAGAGGAGGGGAGCAATGCAGGGAGGGGAGACGAGGGGAGCAATCTGATAGTGTAAGTCCTCTTACTTTGCTCTTGTTAAAAATTTAGGCAGGACACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATGATGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTCAAACCCCATCTCTACTAATAATAAAAAAATTAGCTGGGCATGGTGGCACGCGCCTGTAATCCCAGCCACTCAGGAGGCAGAGGCAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAACCGAGATCCGCCACTGCACTCCAGCCTGGGCAACAGACCGAGACTCCATCCCCCCCAAAAAAAAAAAAAATCCTGCTGGGATTT
Task1_train_22491
A variant on Chromosome 16 in gene EARS2, EARS2 (glutamyl-tRNA synthetase 2, mitochondrial| glutamyl-tRNA synthetase 2, mitochondrial) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome
TACACACATACATACATACATTTTTCTGTAGACATGGAGTTTCACTATATTGCCCAGGTTGGTCTCAAACTCCCAGGCTTAAATGATCCTCCTGCACTGGCCTCCCAAAGTGCTGGGATTACAGACATGAGCCACTGTGCCCGCCCTCCTTCTACTTTCAAACATAAGGGAGGCTGAGTGAGCAAGCCCTGGGCCCCCCATTCCACTTTGCCCAAAGGGATTTAACTTCTAGCTATTTATATATCAAGAGCCTGAATGAGCTTTCATTTTCAGAAAGGGTTCCATCATTAAAGAAAAAAAGGTCTGAAAACAATCAGGCTAAACCCATCTCCATTACTCTCAAGACACGAGCTGCAGAACAGTACGCCCATTGCCTGGCTGTACCAGAGACTCTGAGTCAACTGGGTTTGGTTGGGGTCTGAGCATATTTTAGAAGCTTCCTAGCTGATTCCAAAGCACGATCAAGAGTTAAGAACCAGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGTACTTTGGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGAACAGCCTGGACAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAAGCGTGGTGGCGGGTGCCTGTAATCCCAGGTACTCGGGAGGCTGAGGCAGGACAATCGCTTGAACCCAGGAGACGGAGGTTGCGGTGAGCCGAGATCGCGCCATTGCACTCCAGAATGGGGGACAAGAAGTTCTGTCTCAAAAAAAAAAAAAAAAAGTTAAGAACCGTAGTGCTGGGAGCTGCTTCTTGTGAGCAGCAGCTCAGTCCCATACGGTCAGCAGGCATCGTGATCAGGCATAGGCCTAAAGCGCTATATCCCTCACTAGGTGTGTGACTTTGGCAAGTTACTCAGCTTCTCTGAGCTTCACAATCCTCTTACAAACAGTGGAGATATGTATCTACCCCTTAATAGTATGTTGTGTTAAATGAAATGAGACCAGCAGGCAGGCTATTCTGGACACATTTTCAGAAATCCTTCAGGTCATCCTATTTGATGCTTGCTTCTTCAAGGTTTGGGTCTAAGTCTTGGACCATGGGTAAGTGCTCAGCTTGAAATAAACTAGATTCATCTGGCAGTAAAATGAAGAAGGAAAAAAAGAAACTAAATCCATATTAATTCTAGTCATACTGTTAGCATACATGCTTGTAATAATTGTCACAATCATAGGGTCTGTCATTTTTTGTGCTTACAGTGTGACAGGTGCTGGGCTGGGTACCTTACACTCCTGAGCTCAGTGAATCCTAACCCAATGAGGTAGACACTTATCCCCATTTTCCAGATATGCAACTGAGGCTCAGAGACTATAAGTCCCTTGAGGGCAGGGATCATGTCTATCTCACCCACTACTGTAGCCCCAGCACTTAATGTGGTGTCTGGCAAAATAAACATTTATTGAATAAAAGAATAAACTTGTCCAAGGTCACCTGGCTGGTAGGTGGCAAAGCTGGGACCAAAGAGCAGGACTGTCTGAGCCAAAGCCCTGCTCCTCCTGGCCATGCTCTCTGCTGCCAGGACTATTCAGGTGGGCACGTACCTGCAAAACCTGAGCCACAGTTGGTGATGATGTCCAACAAGGAATCGGGCAGGAAGCCATCAGCAGCAAAGTGCTCCAGGAAAACGTCCCCTTGCCTCTTGGAGAGCTTGCTGCCATCCCTGTTGAGGAGCAGGGGCAGGTGGGCGAAGTGGGGTGGCTGCCAGCCCAGGGCCTGGTAGAGGAGCAGGTGCTTGGCAGTGGAGACGAGCCACTCAGAGCCTCGCAGCACGTGGCTGATGCCCATGTGGTGGTCGTCCACCACGCAGGCCAGGTGGTATGTGGGGAAGCCGTCGCTCTTCATGATGACTGGGTCTCCCTCCACGCTGGCCACTTCATGCCTATTCCAGCCATAGACCAGGTCCTGGAAGGCTGGCACCACCTGCTCCAGGCGGAAGCGGATCGCAGGCTTGGGGTCCTTGGCCAGCTTCTGGGCCACCTGCTCCTGGCTCATGTTCCTGCACCGATTGTCATACCTGATGGGGAGCAGAGCAGCATGAGTACTGTTGATGGAAAGGTTGATGGACAGGAGTCCTACCTCTGTCATAGCTGTGTGACCTTAAGCAAGTCAGTTACTGCTGCAAGCTGCTTCCTCAGTCTATAACAGGGATGATGGTACAGTTGTGTGGAAAACTGAGATAACATGGTGTAGCAGACACTAATGTCTGCCTATCTACCAGCCATTCCACGCTTCTTCCTTGCTAACAAGAAAATAGCAAAATGCTTAGTCCGAGGGGTTGAATCCTGATTGGTATAGCCAATCTTGCAATCCTATTGCTCCATGCCAGTGACCAGTCCAGGCAGGAATGTAACCCCATCCTAGTCACTGGGATGCAAAGAAAAGCATGCCTGGGGAGTAAGAAAGGTTTAAGGTTCCGGGAAAGGTTTTTCTCTCCAAAGGACAAGAAGAGAAAGCCACAGGAGGAAAATCCCTTCTTAAAATTTCCCACTGCCCCACTTCTGTCCTCTTTGGATGTTGTCCTGTAAGGGGAGCATGCTTGGACCTGCGGCAGCTACTTGCAACTGCAGGAGGGAAGGCAATGAAGTCAGAGAGAAGCCAAAATAGAGCCCTGGTGTCTCTACACTGCTAGTCTCATCCTGGAGTCACCCACCTCCAGCCTTGTGCAGAATCAAAAGACAAATGTCTATGATTGATGCCCTGGCTACTGAAAGTGTGGTCTGTGGGCCCCTAGCATCAGCCTCTTGGGAGTCTGCCAGAAATGCAGACTCTTAGGCTCCACCCCAGACCTACTGAGTCAGAATCTGAACATTAACTAGGTCCCCAGGTGATCCATCTGTGAGTTAAAGTATCGTTTGTCCCTTCTAACAGGGTATTCCACTAACTGCACCCAAAAGCGTTCTGAGACACAGATGGAATGCTTGTAAGGTTAGTCTTTGCCACAGCTAAGTGTTCAATCAATCAATAAATGGTGCACAGGGCTGGACACAGTTGCTCACGTCTGTAATCCCAGTGTTTTGGGAGGTCAAGGTAGAAGGACAGCCTGACCTCAAGGGTTCAAGACCAGCGTGGGTAACATAGCAAAATCCTGTCTCTTATTTAAAAATTTAAAATACCAGCCTGGGCAACATAGTGAGACTCTGTCTCTACAAAACAAAACAAAACAAAATCAGCCAGGTGTGGTGGTGCATTCCTGTAGTCCCAGCTCTGTGGGAGGCCAAGGTGGAAGAATCACTGGAGCCCAGGAGGTTGAGGCTGCAGTAAACTATGATGGCACCACTGCACTCTAGCCTGGGTGACACAGCGAGACCCTGTCTCAAAAAAAAAACTTTTTTTTTCTTTTTTTTTTTTTTTTTTGAGATAGAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGTCGTGACCTTGACTCACTGCAACCTCCACCTCCAGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTAGGATTACAGGTGCCTGCCACCACAACCGGCTAATTTTTATATTTTTAGTAGAAATGGGGTTTCACCACGTTGGTCAGGCTGGTCTCGAACTCCTGATCTCGTGATCTACCCGCCTCGGCCTCCCATAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCGGCCAAAAAAGAAATTTTTACAAATGAGTCAGTTGCACATGAGTGAACAGGAGGGTGTTCAGCTGCAGAAGCAGGGCAGCATTATGTCTGAATCAAAGGAACTTGTTTCTTCAAGCTCTTCTGGCAGGAATTCTGACAGTGAGTTTGACAAAAAGTTAAAGAAGAAAAAGTAAGTTGCTCCAGAAAAACTTGTAAAGGAACAAAAGACTGGCAAAACTTTGGGAGCTCTGTCATCTTCCAAACAGAGCAGCGGCAGTAAACATAATAACATGTTTATTTTCTTTTTTAAATTTCATATAGAGATGGGGTTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTAGTCTCAAGTGATCCACCCTCCTCAGCCTCCCAAAGTGCTGTGATTAGATTACAGGCCACTGTACTCAGCTG
TACACACATACATACATACATTTTTCTGTAGACATGGAGTTTCACTATATTGCCCAGGTTGGTCTCAAACTCCCAGGCTTAAATGATCCTCCTGCACTGGCCTCCCAAAGTGCTGGGATTACAGACATGAGCCACTGTGCCCGCCCTCCTTCTACTTTCAAACATAAGGGAGGCTGAGTGAGCAAGCCCTGGGCCCCCCATTCCACTTTGCCCAAAGGGATTTAACTTCTAGCTATTTATATATCAAGAGCCTGAATGAGCTTTCATTTTCAGAAAGGGTTCCATCATTAAAGAAAAAAAGGTCTGAAAACAATCAGGCTAAACCCATCTCCATTACTCTCAAGACACGAGCTGCAGAACAGTACGCCCATTGCCTGGCTGTACCAGAGACTCTGAGTCAACTGGGTTTGGTTGGGGTCTGAGCATATTTTAGAAGCTTCCTAGCTGATTCCAAAGCACGATCAAGAGTTAAGAACCAGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGTACTTTGGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGAACAGCCTGGACAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAAGCGTGGTGGCGGGTGCCTGTAATCCCAGGTACTCGGGAGGCTGAGGCAGGACAATCGCTTGAACCCAGGAGACGGAGGTTGCGGTGAGCCGAGATCGCGCCATTGCACTCCAGAATGGGGGACAAGAAGTTCTGTCTCAAAAAAAAAAAAAAAAAGTTAAGAACCGTAGTGCTGGGAGCTGCTTCTTGTGAGCAGCAGCTCAGTCCCATACGGTCAGCAGGCATCGTGATCAGGCATAGGCCTAAAGCGCTATATCCCTCACTAGGTGTGTGACTTTGGCAAGTTACTCAGCTTCTCTGAGCTTCACAATCCTCTTACAAACAGTGGAGATATGTATCTACCCCTTAATAGTATGTTGTGTTAAATGAAATGAGACCAGCAGGCAGGCTATTCTGGACACATTTTCAGAAATCCTTCAGGTCATCCTATTTGATGCTTGCTTCTTCAAGGTTTGGGTCTAAGTCTTGGACCATGGGTAAGTGCTCAGCTTGAAATAAACTAGATTCATCTGGCAGTAAAATGAAGAAGGAAAAAAAGAAACTAAATCCATATTAATTCTAGTCATACTGTTAGCATACATGCTTGTAATAATTGTCACAATCATAGGGTCTGTCATTTTTTGTGCTTACAGTGTGACAGGTGCTGGGCTGGGTACCTTACACTCCTGAGCTCAGTGAATCCTAACCCAATGAGGTAGACACTTATCCCCATTTTCCAGATATGCAACTGAGGCTCAGAGACTATAAGTCCCTTGAGGGCAGGGATCATGTCTATCTCACCCACTACTGTAGCCCCAGCACTTAATGTGGTGTCTGGCAAAATAAACATTTATTGAATAAAAGAATAAACTTGTCCAAGGTCACCTGGCTGGTAGGTGGCAAAGCTGGGACCAAAGAGCAGGACTGTCTGAGCCAAAGCCCTGCTCCTCCTGGCCATGCTCTCTGCTGCCAGGACTATTCAGGTGGGCACGTACCTGCAAAACCTGAGCCACAGTTGGTGATGATGTCCAACAAGGAATCGGGCAGGAAGCCATCAGCAGCAAAGTGCTCCAGGAAAACGTCCCCTTGCCTCTTGGAGAGCTTGCTGCCATCCCTGTTGAGGAGCAGGGGCAGGTGGGCGAAGTGGGGTGGCTGCCAGCCCAGGGCCTGGTAGAGGAGCAGGTGCTTGGCAGTGGAGACGAGCCACTCAGAGCCTCGCAGCACGTGGCTGATGCCCATGTGGTGGTCGTCCACCACGCAGGCCAGGTGGTATGTGGGGAAGCCGTCGCTCTTCATGATGACTGGGTCTCCCTCCACGCTGGCCACTTCATGCCTATTCCAGCCATAGACCAGGTCCTGGAAGGCTGGCACCACCTGCTCCAGGCGGAAGCGGATCGCAGGCTTGGGGTCCTTGGCCAGCTTCTGGGCCACCTGCTCCTGGCTCATGTTCCCGCACCGATTGTCATACCTGATGGGGAGCAGAGCAGCATGAGTACTGTTGATGGAAAGGTTGATGGACAGGAGTCCTACCTCTGTCATAGCTGTGTGACCTTAAGCAAGTCAGTTACTGCTGCAAGCTGCTTCCTCAGTCTATAACAGGGATGATGGTACAGTTGTGTGGAAAACTGAGATAACATGGTGTAGCAGACACTAATGTCTGCCTATCTACCAGCCATTCCACGCTTCTTCCTTGCTAACAAGAAAATAGCAAAATGCTTAGTCCGAGGGGTTGAATCCTGATTGGTATAGCCAATCTTGCAATCCTATTGCTCCATGCCAGTGACCAGTCCAGGCAGGAATGTAACCCCATCCTAGTCACTGGGATGCAAAGAAAAGCATGCCTGGGGAGTAAGAAAGGTTTAAGGTTCCGGGAAAGGTTTTTCTCTCCAAAGGACAAGAAGAGAAAGCCACAGGAGGAAAATCCCTTCTTAAAATTTCCCACTGCCCCACTTCTGTCCTCTTTGGATGTTGTCCTGTAAGGGGAGCATGCTTGGACCTGCGGCAGCTACTTGCAACTGCAGGAGGGAAGGCAATGAAGTCAGAGAGAAGCCAAAATAGAGCCCTGGTGTCTCTACACTGCTAGTCTCATCCTGGAGTCACCCACCTCCAGCCTTGTGCAGAATCAAAAGACAAATGTCTATGATTGATGCCCTGGCTACTGAAAGTGTGGTCTGTGGGCCCCTAGCATCAGCCTCTTGGGAGTCTGCCAGAAATGCAGACTCTTAGGCTCCACCCCAGACCTACTGAGTCAGAATCTGAACATTAACTAGGTCCCCAGGTGATCCATCTGTGAGTTAAAGTATCGTTTGTCCCTTCTAACAGGGTATTCCACTAACTGCACCCAAAAGCGTTCTGAGACACAGATGGAATGCTTGTAAGGTTAGTCTTTGCCACAGCTAAGTGTTCAATCAATCAATAAATGGTGCACAGGGCTGGACACAGTTGCTCACGTCTGTAATCCCAGTGTTTTGGGAGGTCAAGGTAGAAGGACAGCCTGACCTCAAGGGTTCAAGACCAGCGTGGGTAACATAGCAAAATCCTGTCTCTTATTTAAAAATTTAAAATACCAGCCTGGGCAACATAGTGAGACTCTGTCTCTACAAAACAAAACAAAACAAAATCAGCCAGGTGTGGTGGTGCATTCCTGTAGTCCCAGCTCTGTGGGAGGCCAAGGTGGAAGAATCACTGGAGCCCAGGAGGTTGAGGCTGCAGTAAACTATGATGGCACCACTGCACTCTAGCCTGGGTGACACAGCGAGACCCTGTCTCAAAAAAAAAACTTTTTTTTTCTTTTTTTTTTTTTTTTTTGAGATAGAGTCTCGCTGTGTCACCCAGGCTGGAGTGCAGTGTCGTGACCTTGACTCACTGCAACCTCCACCTCCAGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTAGGATTACAGGTGCCTGCCACCACAACCGGCTAATTTTTATATTTTTAGTAGAAATGGGGTTTCACCACGTTGGTCAGGCTGGTCTCGAACTCCTGATCTCGTGATCTACCCGCCTCGGCCTCCCATAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCGGCCAAAAAAGAAATTTTTACAAATGAGTCAGTTGCACATGAGTGAACAGGAGGGTGTTCAGCTGCAGAAGCAGGGCAGCATTATGTCTGAATCAAAGGAACTTGTTTCTTCAAGCTCTTCTGGCAGGAATTCTGACAGTGAGTTTGACAAAAAGTTAAAGAAGAAAAAGTAAGTTGCTCCAGAAAAACTTGTAAAGGAACAAAAGACTGGCAAAACTTTGGGAGCTCTGTCATCTTCCAAACAGAGCAGCGGCAGTAAACATAATAACATGTTTATTTTCTTTTTTAAATTTCATATAGAGATGGGGTTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTAGTCTCAAGTGATCCACCCTCCTCAGCCTCCCAAAGTGCTGTGATTAGATTACAGGCCACTGTACTCAGCTG
Task1_train_22492
A mutation on Chromosome 16 affecting EARS2 (glutamyl-tRNA synthetase 2, mitochondrial) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome
AGCACTTTGGGAGGCCGAGGCAGGAGAATTAACTTGAGGTCAGGGGTTCAACAGCAGCCTGGGCAACATAGCAAGACCCTACCTCTACAAAAACATAAGTTAATAAAATTAGCTGGGCATGGTGGCACACAGCTATGGTGCCAGCTACCCAGGAGGCTAAGGTGAGAGGATCCCTTGAGCTCAGGAATTTGAGATTACAGTGAGCTGTGTTTGAACCACTGCGCTCTAGCCTGGGCAACAGAGCAAGATTTTGTTTGTTAAAAAAAAAAAAAAAGAAATAATTAATCCACTCATCTGTCTTTTCCCTTGGCACTAAGCACATGGTCTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGATGCAATCTCGGCTCACTGCAAGCTCCGCCTTCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGAGACTACAGGCACCCGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATGCACCAGCCTCGGCCTCCCAAAGTTTTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAACCATTTTATACTCTTTAGGAATCCAGAGTTTAGTGAGTAATTTACCTGAGATTAGAACACACATCTCAAAATAGTCTTGGGGTTTTTCTTTCTTTTTTTTTCAATCTCTAGACTAGCAGAGTCTTGGTATTTTTCCTTGGGAATCTCCCCTTTCCTAGTCACACCCGTCCATACAGGTAGACAACTGTCGACCCATGAAAAGGAAACACACTCCTCTTTGTTCTCCCTGACCTTAGCTGTCCTCAGGATAAAACTTCCCACAAGATCAACTTCAGAAGCTGTACGTGTTTTGTGTGGCTTATACAACATGGTTAAAAAAAATCTGAGCCCAGATTTAATAATGGTTAAGTATTCATCCAGAAAAACTGGATTTCTGGCTCCTCTTGCAACTCAGAGGATTGGACAAGCTGGGCCAGCATTCCCGCATGGGCACAAGGAGCTGGAGCTCAGAGGCACTCCCAACTCTGGATGAGGTGTGGTTTTCACAGCTCAGCACTGGCCCAGCTCCTCCAGTTCCCACTTGGCCCTGTGTTTCCTGCCTGGCCCCTGTAGGGAATGAACTTGAGATTCTGAGGTGAAAACAGGAATCTCAAAACAGCCTTGGCAGTGGCTCACACCTGTAATCCCAGCTCTTTGGGAGGCTGTAGCAGGAGGATTGCTTGAGCCCAGGAGTTTGAGAATAGCTTGGGCAACACAGTGAGATCTCATCTCTACAAAAAAATTAAAAATTAGCCAGGCGTGGTGGTGCGTGCCTGTAGTCCCAACTACTTGGGAGGCTAAGGTGGAGGATCACTTGAGCCCAGGTCGAGGCTACAGTAAGTTATGATTGTGCCATGGAACTCTAGCCTGGGTAACAAAATGAGACCCTGACTCTAAAAAATTAAAAAATAAAGAAACCAAGTTGGGCGCGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGTCGAGGCAGGTGGATCACGAGGTCAGGAGGTCAAGATCATCCTTGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAACTTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTTCCAGCTACTTGGAGGCTGAGGCAGAAGAATGGCGTGAACCCGGAAGGCGGAGCTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAACAATAAATAAATAAAAATAAAGAAACCAGTCTTGGAGCTGTGTTTCAGAGAGCTTCGGCATTTTTTCAGGTGTCATCTGCCACCCCGGGCAGGGCAGTACAAATGTAGCCACTTCTCCAGGAACTCCCCATTTTCCACTCAGAACTCCATGAGAAGACCCACAGGCTCCTTTTCCTGCTTCCTGTTCCTTCCCTGCAGAAAGATCCTTTCTCTGCCAGGCTTACCTGCCCACTCCAGCATGTCCTCAATATTCTCCGCTGCCCCAGGCACAACGCGAGTCTGATCTGTGTCCTCTAGCCTCAGGATGAAGCTCCCCTGGTACTTCTTAGCAAAGATGTAGTTGTACAAGGCAGTGCGGAGGCCACCCAGGTGCAAGAAGCCTGGAGAAGAGAACAGCTCAGATAAGACAGGGAAGATAAGCTAATAGGCCTCAGCAAGGGGCAAGTAAGCACTACTGTGACAGAATGTTGCAATAAATTTAAAAGACCAGCAGGACACATTGGCTCACGCCTGTAATCCTACCACTTTGGGAGGCCAAGGCCGGGGGGATCACTTGAGCCCAGGAGGTTCCTGTAGGTTTTTTAAGACAAGAGTCTCACTCTGTCACCCAAGCTGGAGTGCAGTGGCACAGTCTTGGCTCACTGCAACCTCTGCCTCTTGTGTTTAAGCAATTCTCATGCCCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTGCCACCACGTCCAGCTACATGTTTGTATTTTTGGTAGAGACAGGCATTCGCCATGTTGGCAAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCCCCCCAGCCTCGGCCTCCCAAGTGCTGGGATCACAGGCAAGAGCCATCACACCTGGCCAATTTTTGTATTTTTAGTAAAGATAGGATTTTGCCATGGTGGTCAGGCTGATCTCGAACTCCTGACCTCAAGTGATCCATCTGCCTTGGCTTCCCAAAGTGCTGGGATTACAAGCGTGAGCCATTGTGCTTGGCCTGAGTTTGAGATCTGCCTGGGCAACATGGTGAGACCTTGTCTTAGCAAAAAATATAAAAATTTAGCTGGGCATGGTGGTACATGCCTGTGGTTTCAGTTACTGAGGTGGGAGGATCACCTGAGCCTGGGGACGCTGAGGCTGCAGCGAGCCATGATCACGCCTCTGCACTCCAGCCTGGGCAGCAGTAGAGTGAGACTCTGTCTCAAACAAAAAAAATTAAAAATTAAAAAATTTTTTTTCAAAGACTAAGAACTAGTTACCCCTGTGCCCTGTCTCCAGACACATTTAATCCCTCATCCTGAAAATGGAAACCACCCAGGATTTGGAGCATGTCATTTTATTAAAAGGCTCCAATTTTCCCCAACTGCATCCACCACTCTATTTTGATATTTGTCTCAAGGCCAAGTTTCGCCTGAAAGAGAAGCAGAGAGTTATTCATTGAGGCCATATCATGTACATTTAACTTACAGAAATTCAATGATGTGCGCTGGGAAAAAAATTAATTACAAACAAACTAGAAATTTAAAATACTGTACAATCATATTGTGGGCCAGGTGCAGTAGCTCACACCTCTAATCCCAGCACTTTTGGAGGCAGAGGCACGAGGATCACCTGGGTCTCTAAATTTGAGACCAGCCTGGGCAACATTGTGAGATCCTGTCTCTACAAAGAAAAAAAAAATCGGTGGGGCATGGTGGCTCACACCTTTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAAGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGTTGAAACCCCGTCTCTACTAAAAATACCACAAAAAAAATTAGCTGGGCATGGTGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGTTGAGGCAGGAGAACTGCTTGAACCCAGGAGACAGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGCCTGGGCGACAGGGCGAGACTCCATCTCCAAAAAAAAAAAAAAAATCACATTTTGCATATGCAGTCTATGCAGTGTGCATGACTGTCCACGTCGTACATTTTAAATTTCATCTACTTGAGATTTTTACTTTTTTAAAGAAACAAAATTCATTTTTGAAATTTGAGATGGGGTCTCACTCTTGCCCAGGCTGAAGTCCAGTGGTACAGTCACGGCTCACTGCAGCCTCAACCACCCAGGCTCAATCAATCCTCCCACGTCAGCCTCCCAAGTAGCTGGAACTACAAGTGTACACCACCATGCCCGGCTAATATTTGTTTTTTGGTTTTTTTTTTGCAGA
AGCACTTTGGGAGGCCGAGGCAGGAGAATTAACTTGAGGTCAGGGGTTCAACAGCAGCCTGGGCAACATAGCAAGACCCTACCTCTACAAAAACATAAGTTAATAAAATTAGCTGGGCATGGTGGCACACAGCTATGGTGCCAGCTACCCAGGAGGCTAAGGTGAGAGGATCCCTTGAGCTCAGGAATTTGAGATTACAGTGAGCTGTGTTTGAACCACTGCGCTCTAGCCTGGGCAACAGAGCAAGATTTTGTTTGTTAAAAAAAAAAAAAAAGAAATAATTAATCCACTCATCTGTCTTTTCCCTTGGCACTAAGCACATGGTCTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGATGCAATCTCGGCTCACTGCAAGCTCCGCCTTCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGAGACTACAGGCACCCGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATGCACCAGCCTCGGCCTCCCAAAGTTTTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAACCATTTTATACTCTTTAGGAATCCAGAGTTTAGTGAGTAATTTACCTGAGATTAGAACACACATCTCAAAATAGTCTTGGGGTTTTTCTTTCTTTTTTTTTCAATCTCTAGACTAGCAGAGTCTTGGTATTTTTCCTTGGGAATCTCCCCTTTCCTAGTCACACCCGTCCATACAGGTAGACAACTGTCGACCCATGAAAAGGAAACACACTCCTCTTTGTTCTCCCTGACCTTAGCTGTCCTCAGGATAAAACTTCCCACAAGATCAACTTCAGAAGCTGTACGTGTTTTGTGTGGCTTATACAACATGGTTAAAAAAAATCTGAGCCCAGATTTAATAATGGTTAAGTATTCATCCAGAAAAACTGGATTTCTGGCTCCTCTTGCAACTCAGAGGATTGGACAAGCTGGGCCAGCATTCCCGCATGGGCACAAGGAGCTGGAGCTCAGAGGCACTCCCAACTCTGGATGAGGTGTGGTTTTCACAGCTCAGCACTGGCCCAGCTCCTCCAGTTCCCACTTGGCCCTGTGTTTCCTGCCTGGCCCCTGTAGGGAATGAACTTGAGATTCTGAGGTGAAAACAGGAATCTCAAAACAGCCTTGGCAGTGGCTCACACCTGTAATCCCAGCTCTTTGGGAGGCTGTAGCAGGAGGATTGCTTGAGCCCAGGAGTTTGAGAATAGCTTGGGCAACACAGTGAGATCTCATCTCTACAAAAAAATTAAAAATTAGCCAGGCGTGGTGGTGCGTGCCTGTAGTCCCAACTACTTGGGAGGCTAAGGTGGAGGATCACTTGAGCCCAGGTCGAGGCTACAGTAAGTTATGATTGTGCCATGGAACTCTAGCCTGGGTAACAAAATGAGACCCTGACTCTAAAAAATTAAAAAATAAAGAAACCAAGTTGGGCGCGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGTCGAGGCAGGTGGATCACGAGGTCAGGAGGTCAAGATCATCCTTGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAACTTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTTCCAGCTACTTGGAGGCTGAGGCAGAAGAATGGCGTGAACCCGGAAGGCGGAGCTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAACAATAAATAAATAAAAATAAAGAAACCAGTCTTGGAGCTGTGTTTCAGAGAGCTTCGGCATTTTTTCAGGTGTCATCTGCCACCCCGGGCAGGGCAGTACAAATGTAGCCACTTCTCCAGGAACTCCCCATTTTCCACTCAGAACTCCATGAGAAGACCCACAGGCTCCTTTTCCTGCTTCCTGTTCCTTCCCTGCAGAAAGATCCTTTCTCTGCCAGGCTTACCTGCCCACTTCAGCATGTCCTCAATATTCTCCGCTGCCCCAGGCACAACGCGAGTCTGATCTGTGTCCTCTAGCCTCAGGATGAAGCTCCCCTGGTACTTCTTAGCAAAGATGTAGTTGTACAAGGCAGTGCGGAGGCCACCCAGGTGCAAGAAGCCTGGAGAAGAGAACAGCTCAGATAAGACAGGGAAGATAAGCTAATAGGCCTCAGCAAGGGGCAAGTAAGCACTACTGTGACAGAATGTTGCAATAAATTTAAAAGACCAGCAGGACACATTGGCTCACGCCTGTAATCCTACCACTTTGGGAGGCCAAGGCCGGGGGGATCACTTGAGCCCAGGAGGTTCCTGTAGGTTTTTTAAGACAAGAGTCTCACTCTGTCACCCAAGCTGGAGTGCAGTGGCACAGTCTTGGCTCACTGCAACCTCTGCCTCTTGTGTTTAAGCAATTCTCATGCCCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTGCCACCACGTCCAGCTACATGTTTGTATTTTTGGTAGAGACAGGCATTCGCCATGTTGGCAAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCCCCCCAGCCTCGGCCTCCCAAGTGCTGGGATCACAGGCAAGAGCCATCACACCTGGCCAATTTTTGTATTTTTAGTAAAGATAGGATTTTGCCATGGTGGTCAGGCTGATCTCGAACTCCTGACCTCAAGTGATCCATCTGCCTTGGCTTCCCAAAGTGCTGGGATTACAAGCGTGAGCCATTGTGCTTGGCCTGAGTTTGAGATCTGCCTGGGCAACATGGTGAGACCTTGTCTTAGCAAAAAATATAAAAATTTAGCTGGGCATGGTGGTACATGCCTGTGGTTTCAGTTACTGAGGTGGGAGGATCACCTGAGCCTGGGGACGCTGAGGCTGCAGCGAGCCATGATCACGCCTCTGCACTCCAGCCTGGGCAGCAGTAGAGTGAGACTCTGTCTCAAACAAAAAAAATTAAAAATTAAAAAATTTTTTTTCAAAGACTAAGAACTAGTTACCCCTGTGCCCTGTCTCCAGACACATTTAATCCCTCATCCTGAAAATGGAAACCACCCAGGATTTGGAGCATGTCATTTTATTAAAAGGCTCCAATTTTCCCCAACTGCATCCACCACTCTATTTTGATATTTGTCTCAAGGCCAAGTTTCGCCTGAAAGAGAAGCAGAGAGTTATTCATTGAGGCCATATCATGTACATTTAACTTACAGAAATTCAATGATGTGCGCTGGGAAAAAAATTAATTACAAACAAACTAGAAATTTAAAATACTGTACAATCATATTGTGGGCCAGGTGCAGTAGCTCACACCTCTAATCCCAGCACTTTTGGAGGCAGAGGCACGAGGATCACCTGGGTCTCTAAATTTGAGACCAGCCTGGGCAACATTGTGAGATCCTGTCTCTACAAAGAAAAAAAAAATCGGTGGGGCATGGTGGCTCACACCTTTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAAGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGTTGAAACCCCGTCTCTACTAAAAATACCACAAAAAAAATTAGCTGGGCATGGTGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGTTGAGGCAGGAGAACTGCTTGAACCCAGGAGACAGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGCCTGGGCGACAGGGCGAGACTCCATCTCCAAAAAAAAAAAAAAAATCACATTTTGCATATGCAGTCTATGCAGTGTGCATGACTGTCCACGTCGTACATTTTAAATTTCATCTACTTGAGATTTTTACTTTTTTAAAGAAACAAAATTCATTTTTGAAATTTGAGATGGGGTCTCACTCTTGCCCAGGCTGAAGTCCAGTGGTACAGTCACGGCTCACTGCAGCCTCAACCACCCAGGCTCAATCAATCCTCCCACGTCAGCCTCCCAAGTAGCTGGAACTACAAGTGTACACCACCATGCCCGGCTAATATTTGTTTTTTGGTTTTTTTTTTGCAGA
Task1_train_22493
A mutation on Chromosome 16 affecting EARS2 (glutamyl-tRNA synthetase 2, mitochondrial) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome
CATAAGTTAATAAAATTAGCTGGGCATGGTGGCACACAGCTATGGTGCCAGCTACCCAGGAGGCTAAGGTGAGAGGATCCCTTGAGCTCAGGAATTTGAGATTACAGTGAGCTGTGTTTGAACCACTGCGCTCTAGCCTGGGCAACAGAGCAAGATTTTGTTTGTTAAAAAAAAAAAAAAAGAAATAATTAATCCACTCATCTGTCTTTTCCCTTGGCACTAAGCACATGGTCTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGATGCAATCTCGGCTCACTGCAAGCTCCGCCTTCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGAGACTACAGGCACCCGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATGCACCAGCCTCGGCCTCCCAAAGTTTTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAACCATTTTATACTCTTTAGGAATCCAGAGTTTAGTGAGTAATTTACCTGAGATTAGAACACACATCTCAAAATAGTCTTGGGGTTTTTCTTTCTTTTTTTTTCAATCTCTAGACTAGCAGAGTCTTGGTATTTTTCCTTGGGAATCTCCCCTTTCCTAGTCACACCCGTCCATACAGGTAGACAACTGTCGACCCATGAAAAGGAAACACACTCCTCTTTGTTCTCCCTGACCTTAGCTGTCCTCAGGATAAAACTTCCCACAAGATCAACTTCAGAAGCTGTACGTGTTTTGTGTGGCTTATACAACATGGTTAAAAAAAATCTGAGCCCAGATTTAATAATGGTTAAGTATTCATCCAGAAAAACTGGATTTCTGGCTCCTCTTGCAACTCAGAGGATTGGACAAGCTGGGCCAGCATTCCCGCATGGGCACAAGGAGCTGGAGCTCAGAGGCACTCCCAACTCTGGATGAGGTGTGGTTTTCACAGCTCAGCACTGGCCCAGCTCCTCCAGTTCCCACTTGGCCCTGTGTTTCCTGCCTGGCCCCTGTAGGGAATGAACTTGAGATTCTGAGGTGAAAACAGGAATCTCAAAACAGCCTTGGCAGTGGCTCACACCTGTAATCCCAGCTCTTTGGGAGGCTGTAGCAGGAGGATTGCTTGAGCCCAGGAGTTTGAGAATAGCTTGGGCAACACAGTGAGATCTCATCTCTACAAAAAAATTAAAAATTAGCCAGGCGTGGTGGTGCGTGCCTGTAGTCCCAACTACTTGGGAGGCTAAGGTGGAGGATCACTTGAGCCCAGGTCGAGGCTACAGTAAGTTATGATTGTGCCATGGAACTCTAGCCTGGGTAACAAAATGAGACCCTGACTCTAAAAAATTAAAAAATAAAGAAACCAAGTTGGGCGCGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGTCGAGGCAGGTGGATCACGAGGTCAGGAGGTCAAGATCATCCTTGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAACTTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTTCCAGCTACTTGGAGGCTGAGGCAGAAGAATGGCGTGAACCCGGAAGGCGGAGCTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAACAATAAATAAATAAAAATAAAGAAACCAGTCTTGGAGCTGTGTTTCAGAGAGCTTCGGCATTTTTTCAGGTGTCATCTGCCACCCCGGGCAGGGCAGTACAAATGTAGCCACTTCTCCAGGAACTCCCCATTTTCCACTCAGAACTCCATGAGAAGACCCACAGGCTCCTTTTCCTGCTTCCTGTTCCTTCCCTGCAGAAAGATCCTTTCTCTGCCAGGCTTACCTGCCCACTCCAGCATGTCCTCAATATTCTCCGCTGCCCCAGGCACAACGCGAGTCTGATCTGTGTCCTCTAGCCTCAGGATGAAGCTCCCCTGGTACTTCTTAGCAAAGATGTAGTTGTACAAGGCAGTGCGGAGGCCACCCAGGTGCAAGAAGCCTGGAGAAGAGAACAGCTCAGATAAGACAGGGAAGATAAGCTAATAGGCCTCAGCAAGGGGCAAGTAAGCACTACTGTGACAGAATGTTGCAATAAATTTAAAAGACCAGCAGGACACATTGGCTCACGCCTGTAATCCTACCACTTTGGGAGGCCAAGGCCGGGGGGATCACTTGAGCCCAGGAGGTTCCTGTAGGTTTTTTAAGACAAGAGTCTCACTCTGTCACCCAAGCTGGAGTGCAGTGGCACAGTCTTGGCTCACTGCAACCTCTGCCTCTTGTGTTTAAGCAATTCTCATGCCCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTGCCACCACGTCCAGCTACATGTTTGTATTTTTGGTAGAGACAGGCATTCGCCATGTTGGCAAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCCCCCCAGCCTCGGCCTCCCAAGTGCTGGGATCACAGGCAAGAGCCATCACACCTGGCCAATTTTTGTATTTTTAGTAAAGATAGGATTTTGCCATGGTGGTCAGGCTGATCTCGAACTCCTGACCTCAAGTGATCCATCTGCCTTGGCTTCCCAAAGTGCTGGGATTACAAGCGTGAGCCATTGTGCTTGGCCTGAGTTTGAGATCTGCCTGGGCAACATGGTGAGACCTTGTCTTAGCAAAAAATATAAAAATTTAGCTGGGCATGGTGGTACATGCCTGTGGTTTCAGTTACTGAGGTGGGAGGATCACCTGAGCCTGGGGACGCTGAGGCTGCAGCGAGCCATGATCACGCCTCTGCACTCCAGCCTGGGCAGCAGTAGAGTGAGACTCTGTCTCAAACAAAAAAAATTAAAAATTAAAAAATTTTTTTTCAAAGACTAAGAACTAGTTACCCCTGTGCCCTGTCTCCAGACACATTTAATCCCTCATCCTGAAAATGGAAACCACCCAGGATTTGGAGCATGTCATTTTATTAAAAGGCTCCAATTTTCCCCAACTGCATCCACCACTCTATTTTGATATTTGTCTCAAGGCCAAGTTTCGCCTGAAAGAGAAGCAGAGAGTTATTCATTGAGGCCATATCATGTACATTTAACTTACAGAAATTCAATGATGTGCGCTGGGAAAAAAATTAATTACAAACAAACTAGAAATTTAAAATACTGTACAATCATATTGTGGGCCAGGTGCAGTAGCTCACACCTCTAATCCCAGCACTTTTGGAGGCAGAGGCACGAGGATCACCTGGGTCTCTAAATTTGAGACCAGCCTGGGCAACATTGTGAGATCCTGTCTCTACAAAGAAAAAAAAAATCGGTGGGGCATGGTGGCTCACACCTTTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAAGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGTTGAAACCCCGTCTCTACTAAAAATACCACAAAAAAAATTAGCTGGGCATGGTGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGTTGAGGCAGGAGAACTGCTTGAACCCAGGAGACAGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGCCTGGGCGACAGGGCGAGACTCCATCTCCAAAAAAAAAAAAAAAATCACATTTTGCATATGCAGTCTATGCAGTGTGCATGACTGTCCACGTCGTACATTTTAAATTTCATCTACTTGAGATTTTTACTTTTTTAAAGAAACAAAATTCATTTTTGAAATTTGAGATGGGGTCTCACTCTTGCCCAGGCTGAAGTCCAGTGGTACAGTCACGGCTCACTGCAGCCTCAACCACCCAGGCTCAATCAATCCTCCCACGTCAGCCTCCCAAGTAGCTGGAACTACAAGTGTACACCACCATGCCCGGCTAATATTTGTTTTTTGGTTTTTTTTTTGCAGAGGCAAGGTCTCACTATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTTACACTTCAGCCTCCCAAAGTGCTGGGATTACTGG
CATAAGTTAATAAAATTAGCTGGGCATGGTGGCACACAGCTATGGTGCCAGCTACCCAGGAGGCTAAGGTGAGAGGATCCCTTGAGCTCAGGAATTTGAGATTACAGTGAGCTGTGTTTGAACCACTGCGCTCTAGCCTGGGCAACAGAGCAAGATTTTGTTTGTTAAAAAAAAAAAAAAAGAAATAATTAATCCACTCATCTGTCTTTTCCCTTGGCACTAAGCACATGGTCTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGATGCAATCTCGGCTCACTGCAAGCTCCGCCTTCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGAGACTACAGGCACCCGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATGCACCAGCCTCGGCCTCCCAAAGTTTTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAACCATTTTATACTCTTTAGGAATCCAGAGTTTAGTGAGTAATTTACCTGAGATTAGAACACACATCTCAAAATAGTCTTGGGGTTTTTCTTTCTTTTTTTTTCAATCTCTAGACTAGCAGAGTCTTGGTATTTTTCCTTGGGAATCTCCCCTTTCCTAGTCACACCCGTCCATACAGGTAGACAACTGTCGACCCATGAAAAGGAAACACACTCCTCTTTGTTCTCCCTGACCTTAGCTGTCCTCAGGATAAAACTTCCCACAAGATCAACTTCAGAAGCTGTACGTGTTTTGTGTGGCTTATACAACATGGTTAAAAAAAATCTGAGCCCAGATTTAATAATGGTTAAGTATTCATCCAGAAAAACTGGATTTCTGGCTCCTCTTGCAACTCAGAGGATTGGACAAGCTGGGCCAGCATTCCCGCATGGGCACAAGGAGCTGGAGCTCAGAGGCACTCCCAACTCTGGATGAGGTGTGGTTTTCACAGCTCAGCACTGGCCCAGCTCCTCCAGTTCCCACTTGGCCCTGTGTTTCCTGCCTGGCCCCTGTAGGGAATGAACTTGAGATTCTGAGGTGAAAACAGGAATCTCAAAACAGCCTTGGCAGTGGCTCACACCTGTAATCCCAGCTCTTTGGGAGGCTGTAGCAGGAGGATTGCTTGAGCCCAGGAGTTTGAGAATAGCTTGGGCAACACAGTGAGATCTCATCTCTACAAAAAAATTAAAAATTAGCCAGGCGTGGTGGTGCGTGCCTGTAGTCCCAACTACTTGGGAGGCTAAGGTGGAGGATCACTTGAGCCCAGGTCGAGGCTACAGTAAGTTATGATTGTGCCATGGAACTCTAGCCTGGGTAACAAAATGAGACCCTGACTCTAAAAAATTAAAAAATAAAGAAACCAAGTTGGGCGCGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGTCGAGGCAGGTGGATCACGAGGTCAGGAGGTCAAGATCATCCTTGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAACTTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTTCCAGCTACTTGGAGGCTGAGGCAGAAGAATGGCGTGAACCCGGAAGGCGGAGCTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAACAATAAATAAATAAAAATAAAGAAACCAGTCTTGGAGCTGTGTTTCAGAGAGCTTCGGCATTTTTTCAGGTGTCATCTGCCACCCCGGGCAGGGCAGTACAAATGTAGCCACTTCTCCAGGAACTCCCCATTTTCCACTCAGAACTCCATGAGAAGACCCACAGGCTCCTTTTCCTGCTTCCTGTTCCTTCCCTGCAGAAAGATCCTTTCTCTGCCAGGCTTACCTGCCCACTCCAGCATGTCCTCAATATTCTCCGCTGCCCCAGGCACAACGCGAGTCTGATCTGTGTCCTCTAGCCTCAGGATGAAGCTCCCCTGGTACTTCTCAGCAAAGATGTAGTTGTACAAGGCAGTGCGGAGGCCACCCAGGTGCAAGAAGCCTGGAGAAGAGAACAGCTCAGATAAGACAGGGAAGATAAGCTAATAGGCCTCAGCAAGGGGCAAGTAAGCACTACTGTGACAGAATGTTGCAATAAATTTAAAAGACCAGCAGGACACATTGGCTCACGCCTGTAATCCTACCACTTTGGGAGGCCAAGGCCGGGGGGATCACTTGAGCCCAGGAGGTTCCTGTAGGTTTTTTAAGACAAGAGTCTCACTCTGTCACCCAAGCTGGAGTGCAGTGGCACAGTCTTGGCTCACTGCAACCTCTGCCTCTTGTGTTTAAGCAATTCTCATGCCCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTGCCACCACGTCCAGCTACATGTTTGTATTTTTGGTAGAGACAGGCATTCGCCATGTTGGCAAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCCCCCCAGCCTCGGCCTCCCAAGTGCTGGGATCACAGGCAAGAGCCATCACACCTGGCCAATTTTTGTATTTTTAGTAAAGATAGGATTTTGCCATGGTGGTCAGGCTGATCTCGAACTCCTGACCTCAAGTGATCCATCTGCCTTGGCTTCCCAAAGTGCTGGGATTACAAGCGTGAGCCATTGTGCTTGGCCTGAGTTTGAGATCTGCCTGGGCAACATGGTGAGACCTTGTCTTAGCAAAAAATATAAAAATTTAGCTGGGCATGGTGGTACATGCCTGTGGTTTCAGTTACTGAGGTGGGAGGATCACCTGAGCCTGGGGACGCTGAGGCTGCAGCGAGCCATGATCACGCCTCTGCACTCCAGCCTGGGCAGCAGTAGAGTGAGACTCTGTCTCAAACAAAAAAAATTAAAAATTAAAAAATTTTTTTTCAAAGACTAAGAACTAGTTACCCCTGTGCCCTGTCTCCAGACACATTTAATCCCTCATCCTGAAAATGGAAACCACCCAGGATTTGGAGCATGTCATTTTATTAAAAGGCTCCAATTTTCCCCAACTGCATCCACCACTCTATTTTGATATTTGTCTCAAGGCCAAGTTTCGCCTGAAAGAGAAGCAGAGAGTTATTCATTGAGGCCATATCATGTACATTTAACTTACAGAAATTCAATGATGTGCGCTGGGAAAAAAATTAATTACAAACAAACTAGAAATTTAAAATACTGTACAATCATATTGTGGGCCAGGTGCAGTAGCTCACACCTCTAATCCCAGCACTTTTGGAGGCAGAGGCACGAGGATCACCTGGGTCTCTAAATTTGAGACCAGCCTGGGCAACATTGTGAGATCCTGTCTCTACAAAGAAAAAAAAAATCGGTGGGGCATGGTGGCTCACACCTTTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAAGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGTTGAAACCCCGTCTCTACTAAAAATACCACAAAAAAAATTAGCTGGGCATGGTGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGTTGAGGCAGGAGAACTGCTTGAACCCAGGAGACAGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAGCCTGGGCGACAGGGCGAGACTCCATCTCCAAAAAAAAAAAAAAAATCACATTTTGCATATGCAGTCTATGCAGTGTGCATGACTGTCCACGTCGTACATTTTAAATTTCATCTACTTGAGATTTTTACTTTTTTAAAGAAACAAAATTCATTTTTGAAATTTGAGATGGGGTCTCACTCTTGCCCAGGCTGAAGTCCAGTGGTACAGTCACGGCTCACTGCAGCCTCAACCACCCAGGCTCAATCAATCCTCCCACGTCAGCCTCCCAAGTAGCTGGAACTACAAGTGTACACCACCATGCCCGGCTAATATTTGTTTTTTGGTTTTTTTTTTGCAGAGGCAAGGTCTCACTATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTTACACTTCAGCCTCCCAAAGTGCTGGGATTACTGG
Task1_train_22494
A variant affecting Chromosome 16, within the gene PALB2 (partner and localizer of BRCA2), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Familial cancer of breast
AGTGATTGGTGGTTTTGTAAAACAGGCCCCAGAAAGCTGCCTTCTACCATGTGAGGACACATCTATGAGCCAGGAAATGGGCTCTCACCAGACAGTGAATCCGCCAGCACCTTGATCTTGGACTTCCCAGCCAAAAGAATGGTAAGAAATACACTTTGTTGTTTAAAGGCTACCCAGTCTGTGGTATTTTGTTGTAGCAGCCTAATAGAACTAAGATATGCTTCCTACAGGATTGGTACCAAACAGGCTTTCAAGGATTCCTGAACAGATGAGTTTGAAAAGTGACAAAGGAAATGCTTGACCAAGCAGTTATCTTTATCTTTAATCTCTAGGGCCAACGACTATCGTTCTCTCTTCAAATCCAAGGAAGCAAGTTTTATATGAAAGCACATACTGCAGATGATAGTTCTGAGGTTCTTAGGTTCTTAAAAAAAAAAAAAATTAGCCAAGCGTGGTGGCATGTACCTGTAGTCCCAGCTACTTGGGAAGCTGAGATGGGAAGATGGTGTGAACCCGGGAGGCAGAGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGCAACAAAGCAAGACCCTGCAGAAGTGTCACAGCTAGCTAAGTGCATAGGGATAGAGAATGTCTTTTAGAACATGCACTTATCAAATAAACTTTGCATAAGGTCCAAAAAAACATGTATTGTAACTGTGTGCATTATCCTTGTGAGTTATTAAAGTCAGACCTTGTTTTCTTGATTCACTTCAGCCCAGGCTGCAGTGCAGTGGTACAATCTCGGCTCACTGCAACCTCTCCCTCCCGGGTTCAAGCGATTATCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACGCACTACCATGCCCAGCTAATTTTTGTATGTTAGTAGAGACGGGGTTTCACCGTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCATGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCTGCTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCTCCCAGGCTAGAGTGCAGTGGCACGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGACCCCAGCCTCCCGAGTAGCTGGGATTATAGGTGCCTGCCACCGTGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTGAACTCCTGACCTCATGATGCACCTGCCTCAGCCTCCCAATTGCTGGGATTATAGGCGTGAGCCACTGCCTGGCCAGATAAATACTTATCTATAGATAAATATAAACTGCCTGCATGATAGAGGCTCAGTCAAACTCAGTCAGATTTCAAAGTAAAGATGTCTTCCTAAAGTACCTTAAATTTTCCTTAATTTAGGTTTAGGGAAAGAACACAAATTATGTTTTTTAAATACAGAACGTTCATTACTCTTTATGTGAATTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTTGCCAGGCTTGAGTGAAGTGGTATGATTTCAGCTCACTGCAGCCTCCACCTCCCAGGTTCAAGCCATCCTCCCACCTCAGCCTCCCGAGTAGCTGGAAGTACAGATGCATGCCAGCATGTTTGGCTAATATATATATATATTTTTTTTGGTAGAGACTGGGTCTTGCTCTGTTGTCCAAGTTGGTCTCAAACTCCTGGGCTCAAGCTCTCCTCCCACCTTGACCTCCCAAAGTGCTGGGATTACAGGCATGATCCACCATGTGCTGCCAAAATATTTACCTTAGGGGAAAAAACAGGGCTTGAATAAACACTATTAAAAACCTATATAACCCCATACTAGTAGAGATCAGGATGCAGGGAATCTGGGGTTTGACTCAAGTCCACTAATCTTCATCCTACTTCTGAATATTCCTATCATGATATATAGTATTTCATGTTTTCCATTCTTCTAAGTGACACAAAAATATCTAGTTTTTGTGTTTGCACAGTGCCTTTCAGAATGTCCCACCCATAGAGTAGCAGTTATGCACACTTGCCTGCCAGCCTGCCCTGGAGGAAGACAGTACAGCATCACACCCACGCTGAGAGTCGTCTTAGGGTTAATCACAATGAGCTGAAACACAGGGCTTCGCAACGACTCACTCTCTTTGGCACAGGGATGACTCAGGACAATAAAGAGAAGCCCCTAATTTCGGAGAAAAATAAATATCCCAAATAGACTGTCAAGAGTATGTCAGGAAAAATAAAGATCTGGCAGAGACAAAAACCAAACAATTAAAGCAATGACCGATAGGCTCTGAAGTATCCAGGATTTAACCACTGGCTTGATTTTTTTCCCTGCCGTCTAGGAACTGTTGAGATTATTACTGGACTGGACTTCTGGCTTCTTGTTCTTCTTCTTTTTTTTTTTAGAGACAAGGCCTTCCTGTGTTACCCAGGCTGTTGTTGAACACCTGGCCTCAAGGGATCCTCCCACCTCAGCCTCCCAAAGTGTTGGGATTACAGACGTCAGCCACCGCGCTCAGCCAACTTCTAGCTTTAGCTTCTCCTGCTTCCGGTTCCCAGTGTTTGTTTTAGCCAGTCTTGCCAGGCATGAATCTGATTCATCCATTTCCTTCCCCTTAGATAGTACTACATTTCATGCCATTCATTTGGGGAAATATTGGCAAAGAGAGAATGAGGACACACATGTGCAGGGAGTGCTCAAATTAGAAATATTCATTTGTAAATTGGTTTTTGAACATTCAGAACATGTTTTCCCATAAAAACAATCTTGTACATGGTGGCTGGTTTCTCAGACCAGCCCACAATAGCCTATTTAAAACCCTGACCCTACTACTCTCTATGAATAAGGGTGACCAAAAAAAGATACCATCACCTATGGCTGTTTCTGTGAGAAAATGTGTTAAAGTTCTCTCCTGGCTTTAAAATTACAGGCTCTAATAATAATATTACTGTATGTGTGTATATATATACACACACACACACACACACACATATATACAGATTTTTTTTTTTTGAGACGGAGTTTCGCTCGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTATGCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCACGTTGACCAGGATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCAGCCTCCCAAAGGGCCGGGATTATAGGCGTGAGCCACGGCGTCAGGTCAAATGATTGAATTTATTAATGAAAATAAAATATTTTTATATTTAGAAAACAACTGAGGTAACTCAGGAGGCCGAGGCAGTAGGATAGCTTGAGACAAGCCTGGGAAACACAGCTGAAGACCTCATCATCTAAAAAAATTAAATTAAAATTTAGCTGGGTGCTGTGGCTCATGCCATGTAATCCCATCAACTTGGCAGGCTGAGTGGGGAGGATCGCTTGAGCCCAAGAACTCAAGGCTATAGTGAGCTATGATGGTGCCACTGATCTACAGCCTGAATGAGAGAGTGAGACCCTATCTCTAAAAGGGAAAAAAACTGAGGATTTAAAAATGTTAAATGCTATACAGTTAAGAAGAGGCTGACAAACTATGGCCCACCAGGTAAATCTAACCCAACACAATTTTTTTTTTTGAGACAGAGTCTTGCACTGTCGCCCAGGCTGGCGTGCAGTGGTGCGATGTCTGCTCACTGCAAGCTCTGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTACTTTTAGTAGAGCGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCCGCCTTAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCACCCAACACTTTTTTTGGGGGGATAGGGTCTCACTGTCACCTAGGCTGGAGTGCAGTGGCATAATCAGCTCACTGCAGCCTTGAATTCCTGGCCTC
AGTGATTGGTGGTTTTGTAAAACAGGCCCCAGAAAGCTGCCTTCTACCATGTGAGGACACATCTATGAGCCAGGAAATGGGCTCTCACCAGACAGTGAATCCGCCAGCACCTTGATCTTGGACTTCCCAGCCAAAAGAATGGTAAGAAATACACTTTGTTGTTTAAAGGCTACCCAGTCTGTGGTATTTTGTTGTAGCAGCCTAATAGAACTAAGATATGCTTCCTACAGGATTGGTACCAAACAGGCTTTCAAGGATTCCTGAACAGATGAGTTTGAAAAGTGACAAAGGAAATGCTTGACCAAGCAGTTATCTTTATCTTTAATCTCTAGGGCCAACGACTATCGTTCTCTCTTCAAATCCAAGGAAGCAAGTTTTATATGAAAGCACATACTGCAGATGATAGTTCTGAGGTTCTTAGGTTCTTAAAAAAAAAAAAAATTAGCCAAGCGTGGTGGCATGTACCTGTAGTCCCAGCTACTTGGGAAGCTGAGATGGGAAGATGGTGTGAACCCGGGAGGCAGAGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGCAACAAAGCAAGACCCTGCAGAAGTGTCACAGCTAGCTAAGTGCATAGGGATAGAGAATGTCTTTTAGAACATGCACTTATCAAATAAACTTTGCATAAGGTCCAAAAAAACATGTATTGTAACTGTGTGCATTATCCTTGTGAGTTATTAAAGTCAGACCTTGTTTTCTTGATTCACTTCAGCCCAGGCTGCAGTGCAGTGGTACAATCTCGGCTCACTGCAACCTCTCCCTCCCGGGTTCAAGCGATTATCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACGCACTACCATGCCCAGCTAATTTTTGTATGTTAGTAGAGACGGGGTTTCACCGTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCATGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCTGCTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCTCCCAGGCTAGAGTGCAGTGGCACGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGACCCCAGCCTCCCGAGTAGCTGGGATTATAGGTGCCTGCCACCGTGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTGAACTCCTGACCTCATGATGCACCTGCCTCAGCCTCCCAATTGCTGGGATTATAGGCGTGAGCCACTGCCTGGCCAGATAAATACTTATCTATAGATAAATATAAACTGCCTGCATGATAGAGGCTCAGTCAAACTCAGTCAGATTTCAAAGTAAAGATGTCTTCCTAAAGTACCTTAAATTTTCCTTAATTTAGGTTTAGGGAAAGAACACAAATTATGTTTTTTAAATACAGAACGTTCATTACTCTTTATGTGAATTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTGTTGCCAGGCTTGAGTGAAGTGGTATGATTTCAGCTCACTGCAGCCTCCACCTCCCAGGTTCAAGCCATCCTCCCACCTCAGCCTCCCGAGTAGCTGGAAGTACAGATGCATGCCAGCATGTTTGGCTAATATATATATATATTTTTTTTGGTAGAGACTGGGTCTTGCTCTGTTGTCCAAGTTGGTCTCAAACTCCTGGGCTCAAGCTCTCCTCCCACCTTGACCTCCCAAAGTGCTGGGATTACAGGCATGATCCACCATGTGCTGCCAAAATATTTACCTTAGGGGAAAAAACAGGGCTTGAATAAACACTATTAAAAACCTATATAACCCCATACTAGTAGAGATCAGGATGCAGGGAATCTGGGGTTTGACTCAAGTCCACTAATCTTCATCCTACTTCTGAATATTCCTATCATGATATATAGTATTTCATGTTTTCCATTCTTCTAAGTGACACAAAAATATCTAGTTTTTGTGTTTGCACAGTGCCTTTCAGAATGTCCCACCCATAGAGTAGCAGTTATGCACACTTGCTTGCCAGCCTGCCCTGGAGGAAGACAGTACAGCATCACACCCACGCTGAGAGTCGTCTTAGGGTTAATCACAATGAGCTGAAACACAGGGCTTCGCAACGACTCACTCTCTTTGGCACAGGGATGACTCAGGACAATAAAGAGAAGCCCCTAATTTCGGAGAAAAATAAATATCCCAAATAGACTGTCAAGAGTATGTCAGGAAAAATAAAGATCTGGCAGAGACAAAAACCAAACAATTAAAGCAATGACCGATAGGCTCTGAAGTATCCAGGATTTAACCACTGGCTTGATTTTTTTCCCTGCCGTCTAGGAACTGTTGAGATTATTACTGGACTGGACTTCTGGCTTCTTGTTCTTCTTCTTTTTTTTTTTAGAGACAAGGCCTTCCTGTGTTACCCAGGCTGTTGTTGAACACCTGGCCTCAAGGGATCCTCCCACCTCAGCCTCCCAAAGTGTTGGGATTACAGACGTCAGCCACCGCGCTCAGCCAACTTCTAGCTTTAGCTTCTCCTGCTTCCGGTTCCCAGTGTTTGTTTTAGCCAGTCTTGCCAGGCATGAATCTGATTCATCCATTTCCTTCCCCTTAGATAGTACTACATTTCATGCCATTCATTTGGGGAAATATTGGCAAAGAGAGAATGAGGACACACATGTGCAGGGAGTGCTCAAATTAGAAATATTCATTTGTAAATTGGTTTTTGAACATTCAGAACATGTTTTCCCATAAAAACAATCTTGTACATGGTGGCTGGTTTCTCAGACCAGCCCACAATAGCCTATTTAAAACCCTGACCCTACTACTCTCTATGAATAAGGGTGACCAAAAAAAGATACCATCACCTATGGCTGTTTCTGTGAGAAAATGTGTTAAAGTTCTCTCCTGGCTTTAAAATTACAGGCTCTAATAATAATATTACTGTATGTGTGTATATATATACACACACACACACACACACACATATATACAGATTTTTTTTTTTTGAGACGGAGTTTCGCTCGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTCAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTATGCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCACGTTGACCAGGATGGTCTCGATCTCCTGACCTTGTGATCCACCCACCTCAGCCTCCCAAAGGGCCGGGATTATAGGCGTGAGCCACGGCGTCAGGTCAAATGATTGAATTTATTAATGAAAATAAAATATTTTTATATTTAGAAAACAACTGAGGTAACTCAGGAGGCCGAGGCAGTAGGATAGCTTGAGACAAGCCTGGGAAACACAGCTGAAGACCTCATCATCTAAAAAAATTAAATTAAAATTTAGCTGGGTGCTGTGGCTCATGCCATGTAATCCCATCAACTTGGCAGGCTGAGTGGGGAGGATCGCTTGAGCCCAAGAACTCAAGGCTATAGTGAGCTATGATGGTGCCACTGATCTACAGCCTGAATGAGAGAGTGAGACCCTATCTCTAAAAGGGAAAAAAACTGAGGATTTAAAAATGTTAAATGCTATACAGTTAAGAAGAGGCTGACAAACTATGGCCCACCAGGTAAATCTAACCCAACACAATTTTTTTTTTTGAGACAGAGTCTTGCACTGTCGCCCAGGCTGGCGTGCAGTGGTGCGATGTCTGCTCACTGCAAGCTCTGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTACTTTTAGTAGAGCGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCCGCCTTAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCACCCAACACTTTTTTTGGGGGGATAGGGTCTCACTGTCACCTAGGCTGGAGTGCAGTGGCATAATCAGCTCACTGCAGCCTTGAATTCCTGGCCTC
Task1_train_22495
With a mutation on Chromosome 16 in gene PALB2 (partner and localizer of BRCA2), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; Gastric cancer
AAAGGATTCTCTCAGCAGCAAAGCCAGCCTCGGTTTTTCTGCTTTTTAGCAACTTTTTAGCTGTACTCATCTTTCAACCAACAAAACATCAAGATTTCCATCCTCCATACATGCCTTTTTTAAAAAAAAGAAAAGACCTACTCAGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAACACTTGGGGAAGCTGAGGTGGGTGGATCATTTGAGGTCAAGAGTTCGAGACCCGCCTGGCCAACATGGTGAAATCCTGCTTCTACTAAAGATACAAAAATGAGCCGGGTGTGGTGGTGGGTGCCTGTAGGAGGCTGAAGCAGGAGAATTGCTTGAACCCGGAGGCGGAGGTTGCAGTGGGCCTAGATCACGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGCTTGAAAAAAAAAAAAAAAAAAAAGGCCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGAAGGCCAAGGCGGGCAGATTACCTGAGGTCAGGAGTTCAAAACCAGCCTGGCCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCCGGCGTGGTGTTGGGCGTCTGTAATCCCAACTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCCAAGATCGAGCCACTGCACTCCAGCCTGGGAGATAGAGCGGAGAGTCTGTCTCAAAAACAAACAAAACAAAACCTATGTGCAAAACATGCTACTAGACAAGTTGCCAACCGTAAGGAATTTTCTTTTTTTTTGAGAGACAGTCTCACTCTGTCGTCCAGCCTGGCGTGCAGTGGCGCGATCTCGGCAGCTCCCTGCAACCTCAGCGTCCCCTGGTTCAAGCGATTCTCGTGCATCAGCCTCTGAGGCCTGAGCCTCTGGGACTACAGGCTGGCGTCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACTACGTTGCCTAGGCTGGTCTCAAACTCTGAGCTCAAGCGATCTGCCCATCTCGGCCTCCCAAAGTGCGGGGATTACAGGCGTGAGCCAGGGAGACTGGCCTCCCACCAATCTTATCAATGTCTGGGGATTATCTTGTTTACTTATAAATGATCTTTCTCACCTCCACCAGAAGGTAAGCCAGGATAAGAATAACATCAGCACAAGCTGGAAACATCCTAAAAGTCTATCAGTAAAGTACAGTCTAAAGAAGCAAGGGCACTTCCAAGGCCAGGTGCAGTGGCGGGTTCGTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAGTCGCTTGATCCCAGGAAGCGGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCACCCCAGCATGGGTGGCAGAGTGAGACTCTGTCTCAAAAAAGAAGAAAAACAGAAAAGGAAGAAAAAAGAAACAAAACGAGGGCACTTCCAAACTACAACATACTGTCTAGAACTTAAAAAAGAAAGCAAGGTAGATAAACATGTCCTGACAGGAAAGCTAAACGGAACCTGCAGAACCATTCAGATCATACCATTTATGAACATTCCCTTCTCCAAAAAATATACATAGGATTCCTTTTTGGTGGTTAGGGATACGCCCCTCCTCCACCACCCACATTAACACACGAAAGGACCTGGAAGTACCAGACTTAAAAGATTTACTTGAGGCCGTCCGGGGGGAGAAGTAAAGATTGAGGGTGTGGGAGGGGGGAGGAGCAAGGGTGTCGATACAGCTTTATCTACAAACTGTTACACATTGTATTAATGCGCTGCTACTGTAATGAAATTTGTTCTTTAAACGCCACCACGTGAGCACCACGCTATTTCCACATTTTCATTTTCTGTGCCCCCTCAGCCCTAAGAGGAGGGGGTGGTCAGATGATACTGCTGCCCTCGGACTGCCGAGGACACAAAGCCAGGCCTAAAACCCTGGGAAAGCGGGGTCAGAGTCCTGCGTCCGCCCTTCCCGCACCCCCGGCACCTTTTCCTTCTCCTCACAGCTGAGGGGCTTCCCGGGAGGCTCGTCCATCGGGCAGGCGACAGAACGAAAAGAGCAGCCGTCGCCGACCCCAGGCCTGCCGACACCGGGACCCAGTTGGCCCTGGGCCGGGGAGGCGCCCCAGGAAGGAATGGGGAGCCCGGGATCGCACCCTCAGTGCGCGATCAGCTGACCCACGCGGGCCAAGCGCGCCCTAAACTCCGGCCAATTAAATCCACCATTCGGCCTGCGCACGCGCAGCCGTAGACGGCCGAGCAGTGGAGCGAGGCCGCCTAAAGGAGAGCCGCGCTGTCGATGAGTCCCAGTGGGCCACCTGGAGCGGAAGTGGAGGAGCGGCCGGAAGTAGCCGGAATCTCTGAAAGACTGACCGACTGACTCTGACAGGATCCGGGGCTGAGGGAAGGAGGCGGCGGCCATGGAGTTGGGCGAGCTGCTCTACAACAAGTCTGAGTACATCGAGACGGTGCGCGGGTCCAGATATGTATCCTCCTCTTTCCAACCCTGCGTCCCTTTGAGGCCTGGTCGGCGTTCCCAACCTGCCCCTACCCCACCAACCCCTGTCCCTTTGGCCATTAGTCCCGGATTATCTAGCGATGCCCCGTGTACCGTCTGGCTTTGCTGTTTACTCCGCGCTTGGCCAGTTGAGGCCTTTTGTATTTATTCCTGATTTTCTCATAGGGGTAAAGTGCCTTCGGGAGGATAGGACAAGTCCCATCCTGTTCATACGAATTACAGCTCGGACTTCGGGCCCTTTTACACTGCCTTTTGTATCTGTTAACTTGCGCTAAAAACGATTCGGTTCTTTTTTTTTGAGGAAGGGGGTTGGGGGGCGGAGACTCTGTCGCCCAGTCCTGAGGGCCGCGGCGCGATCTCTGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCGTCTCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTGTATTTTTTGGTAGAGACGGGGTTTCACCGTGTTGGCCAGGCAGGTCCCTAACTCTTGACCTCAGGTGATCGACCCGCCTCGGCCTCCCAAAGTGCTGGCATTACAGGCGTGAGCCACCGCACCCTGCCGATTTGGTTCTTTATGATCAGTACATGATATGTTTGTAAAATCTTGGAAACAGGGCAAGTGGTCAATTAACGTTACTATCGTTATTTTGGTTTTCTTTGCTTTCTCACAACTCTGATACTCATAGTCATTATCCTCGTTTTAAGGCCGTAAAGCCCACGCGTGGAAGTGGGATTTGAATCCGCGTCTGTCTGATGCCACCAAGCTATAGACATTCAAATTATGAGTTTATTCCTTGAGTCCCTAGTTTCCTTTGTGTTTTTATTTTTTGAGACAGGTTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCACAGCTCATTGCAGCCTCGGCCTTCCAGGCTCAAGCGATCCTCTAGCCTCAGCCTTCTGAGGAGCTGGGACTACAGACACGCGCCACCATGCCCGGCTAATTAAAAAATTTTTTTTTTGTTGAGAAGGGGTCTCACTATGTTGCCTAGGCTGGTCTTGAGCTCCTGTCCTCAAGGGATCCGTCTGCCTCAGCCTCTCAAAGTGCTGAGATTACAGGCATGAGCCACCATACTCAGCCATAGTTTCCTAATCCATCATTGCTTTTTTGATATCCTGGACTCACTCCATTGTGGACAGCACCCCACTTTATGTTTTTTTCTCTCAAATGGGAGCTTTCTTGATGGAAACCTGTAGTCCAGAAACCTATTAAGTTTGCTTTCCCCGGTTTTCCGTTGTTTTCTTTTAGGCATCTGGGAACAAAGTCAGTCGCCAGTCAGTGTTGTGTGGAAGCCAGAACATCGTTCTCAATGGCAAGGTAAGGGACAAAGCCAGCTCCAGGCTGCAAACCTTAGCTTGCGTTCTGCTAATTGTCACCACAGCAGGGCAGATAAAATGTTGCCATATCTCCTATTTATTGTTTACATTTTTAATTCTCTTGTTTTTAAATTTTTTATTTTGTAAATTGGATCTCCTTTTTGTTTTTTTTTTGTTTCGG
AAAGGATTCTCTCAGCAGCAAAGCCAGCCTCGGTTTTTCTGCTTTTTAGCAACTTTTTAGCTGTACTCATCTTTCAACCAACAAAACATCAAGATTTCCATCCTCCATACATGCCTTTTTTAAAAAAAAGAAAAGACCTACTCAGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAACACTTGGGGAAGCTGAGGTGGGTGGATCATTTGAGGTCAAGAGTTCGAGACCCGCCTGGCCAACATGGTGAAATCCTGCTTCTACTAAAGATACAAAAATGAGCCGGGTGTGGTGGTGGGTGCCTGTAGGAGGCTGAAGCAGGAGAATTGCTTGAACCCGGAGGCGGAGGTTGCAGTGGGCCTAGATCACGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGCTTGAAAAAAAAAAAAAAAAAAAAGGCCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGAAGGCCAAGGCGGGCAGATTACCTGAGGTCAGGAGTTCAAAACCAGCCTGGCCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCCGGCGTGGTGTTGGGCGTCTGTAATCCCAACTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCCAAGATCGAGCCACTGCACTCCAGCCTGGGAGATAGAGCGGAGAGTCTGTCTCAAAAACAAACAAAACAAAACCTATGTGCAAAACATGCTACTAGACAAGTTGCCAACCGTAAGGAATTTTCTTTTTTTTTGAGAGACAGTCTCACTCTGTCGTCCAGCCTGGCGTGCAGTGGCGCGATCTCGGCAGCTCCCTGCAACCTCAGCGTCCCCTGGTTCAAGCGATTCTCGTGCATCAGCCTCTGAGGCCTGAGCCTCTGGGACTACAGGCTGGCGTCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACTACGTTGCCTAGGCTGGTCTCAAACTCTGAGCTCAAGCGATCTGCCCATCTCGGCCTCCCAAAGTGCGGGGATTACAGGCGTGAGCCAGGGAGACTGGCCTCCCACCAATCTTATCAATGTCTGGGGATTATCTTGTTTACTTATAAATGATCTTTCTCACCTCCACCAGAAGGTAAGCCAGGATAAGAATAACATCAGCACAAGCTGGAAACATCCTAAAAGTCTATCAGTAAAGTACAGTCTAAAGAAGCAAGGGCACTTCCAAGGCCAGGTGCAGTGGCGGGTTCGTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAGTCGCTTGATCCCAGGAAGCGGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCACCCCAGCATGGGTGGCAGAGTGAGACTCTGTCTCAAAAAAGAAGAAAAACAGAAAAGGAAGAAAAAAGAAACAAAACGAGGGCACTTCCAAACTACAACATACTGTCTAGAACTTAAAAAAGAAAGCAAGGTAGATAAACATGTCCTGACAGGAAAGCTAAACGGAACCTGCAGAACCATTCAGATCATACCATTTATGAACATTCCCTTCTCCAAAAAATATACATAGGATTCCTTTTTGGTGGTTAGGGATACGCCCCTCCTCCACCACCCACATTAACACACGAAAGGACCTGGAAGTACCAGACTTAAAAGATTTACTTGAGGCCGTCCGGGGGGAGAAGTAAAGATTGAGGGTGTGGGAGGGGGGAGGAGCAAGGGTGTCGATACAGCTTTATCTACAAACTGTTACACATTGTATTAATGCGCTGCTACTGTAATGAAATTTGTTCTTTAAACGCCACCACGTGAGCACCACGCTATTTCCACATTTTCATTTTCTGTGCCCCCTCAGCCCTAAGAGGAGGGGGTGGTCAGATGATACTGCTGCCCTCGGACTGCCGAGGACACAAAGCCAGGCCTAAAACCCTGGGAAAGCGGGGTCAGAGTCCTGCGTCCGCCCTTCCCGCACCCCCGGCACCTTTTCCTTCTCCTCACAGCTGAGGGGCTTCCCGGGAGGCTCGTCCTTCGGGCAGGCGACAGAACGAAAAGAGCAGCCGTCGCCGACCCCAGGCCTGCCGACACCGGGACCCAGTTGGCCCTGGGCCGGGGAGGCGCCCCAGGAAGGAATGGGGAGCCCGGGATCGCACCCTCAGTGCGCGATCAGCTGACCCACGCGGGCCAAGCGCGCCCTAAACTCCGGCCAATTAAATCCACCATTCGGCCTGCGCACGCGCAGCCGTAGACGGCCGAGCAGTGGAGCGAGGCCGCCTAAAGGAGAGCCGCGCTGTCGATGAGTCCCAGTGGGCCACCTGGAGCGGAAGTGGAGGAGCGGCCGGAAGTAGCCGGAATCTCTGAAAGACTGACCGACTGACTCTGACAGGATCCGGGGCTGAGGGAAGGAGGCGGCGGCCATGGAGTTGGGCGAGCTGCTCTACAACAAGTCTGAGTACATCGAGACGGTGCGCGGGTCCAGATATGTATCCTCCTCTTTCCAACCCTGCGTCCCTTTGAGGCCTGGTCGGCGTTCCCAACCTGCCCCTACCCCACCAACCCCTGTCCCTTTGGCCATTAGTCCCGGATTATCTAGCGATGCCCCGTGTACCGTCTGGCTTTGCTGTTTACTCCGCGCTTGGCCAGTTGAGGCCTTTTGTATTTATTCCTGATTTTCTCATAGGGGTAAAGTGCCTTCGGGAGGATAGGACAAGTCCCATCCTGTTCATACGAATTACAGCTCGGACTTCGGGCCCTTTTACACTGCCTTTTGTATCTGTTAACTTGCGCTAAAAACGATTCGGTTCTTTTTTTTTGAGGAAGGGGGTTGGGGGGCGGAGACTCTGTCGCCCAGTCCTGAGGGCCGCGGCGCGATCTCTGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCGTCTCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTGTATTTTTTGGTAGAGACGGGGTTTCACCGTGTTGGCCAGGCAGGTCCCTAACTCTTGACCTCAGGTGATCGACCCGCCTCGGCCTCCCAAAGTGCTGGCATTACAGGCGTGAGCCACCGCACCCTGCCGATTTGGTTCTTTATGATCAGTACATGATATGTTTGTAAAATCTTGGAAACAGGGCAAGTGGTCAATTAACGTTACTATCGTTATTTTGGTTTTCTTTGCTTTCTCACAACTCTGATACTCATAGTCATTATCCTCGTTTTAAGGCCGTAAAGCCCACGCGTGGAAGTGGGATTTGAATCCGCGTCTGTCTGATGCCACCAAGCTATAGACATTCAAATTATGAGTTTATTCCTTGAGTCCCTAGTTTCCTTTGTGTTTTTATTTTTTGAGACAGGTTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCACAGCTCATTGCAGCCTCGGCCTTCCAGGCTCAAGCGATCCTCTAGCCTCAGCCTTCTGAGGAGCTGGGACTACAGACACGCGCCACCATGCCCGGCTAATTAAAAAATTTTTTTTTTGTTGAGAAGGGGTCTCACTATGTTGCCTAGGCTGGTCTTGAGCTCCTGTCCTCAAGGGATCCGTCTGCCTCAGCCTCTCAAAGTGCTGAGATTACAGGCATGAGCCACCATACTCAGCCATAGTTTCCTAATCCATCATTGCTTTTTTGATATCCTGGACTCACTCCATTGTGGACAGCACCCCACTTTATGTTTTTTTCTCTCAAATGGGAGCTTTCTTGATGGAAACCTGTAGTCCAGAAACCTATTAAGTTTGCTTTCCCCGGTTTTCCGTTGTTTTCTTTTAGGCATCTGGGAACAAAGTCAGTCGCCAGTCAGTGTTGTGTGGAAGCCAGAACATCGTTCTCAATGGCAAGGTAAGGGACAAAGCCAGCTCCAGGCTGCAAACCTTAGCTTGCGTTCTGCTAATTGTCACCACAGCAGGGCAGATAAAATGTTGCCATATCTCCTATTTATTGTTTACATTTTTAATTCTCTTGTTTTTAAATTTTTTATTTTGTAAATTGGATCTCCTTTTTGTTTTTTTTTTGTTTCGG
Task1_train_22496
Chromosome 16 houses a mutation in gene PRKCB (protein kinase C beta). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Progressive sensorineural hearing impairment
GATGTGAGCCACCACACCCGGTTTCTATTCTTATTTTTAATACTTAATTGTTAACACGTATATTTAAACTTATAATGTCCTATATGCAATTTCTCAATATCAATAATCTTTTGAGGAATATAAGACTCAGCACATTTTCATCTTGTAACCCTCCTGCAACTCCCATTTCTTATGACTTGGGTTTTCTCTACTTCTCTATCTCTTCCTCTGTTGAAAACTTTTCATATTATGGAAAAAATTAAACATATATAAAAGTAACATTAGTATAATGCATCCTTGTGTATGCATCACCCAGTTCAATAATGACCCATCATGATCAATTTCTTTTTCATCTGTAATCCTCCCCTTTCTCTCCCCACCTTGGCATACTGAATTATTTTAAATTATTTTATCCATAAAGATGTTAATGTATCCTCAAAGATAAGGATTCTATAAGCAAAGAAAAACAAGACCATTATCACACCAAATATTTTTCATTCCCTAATATCAGTAACAATAATTCCCTTATGTCATCAGAAAGTGAGTATATCCATTTCCCTGATTGCCTTACAGTTTTTTAAACTGTTGGTTTTTTTCCACTTAGAATCCAAACAAGGTCCACATGTTAAATTTAGTTGATATGGGTTGATAGGTGCAGCAAACCACCATGGCACATGTATACCTGTGTAACAAACCTGAATGTTCTGCACGTGTATCCCAGAATTTAAAGTAAAATTAAAAAAATTTAGTTGATATGTTTCTTAAATTCCTTTGAAAATATACGTTTCTCGTCCTATTTTCTCCCCACTTGCAGTCCTCTCTTGTAGTCTATTTGTTGAAGATACCATATTCTTTGCCTTGTAGTTTTCTACATTCTGGGTATTTGGTTGGGGTGGGGGGGGGTGTGTTTGCTGATCGCATCCCTGTGGTGTCATTTAATATGTTCCTCTGTCACTTGTATTTTCTGTAAATCTGTATTTGCATCAAGAGACTTGAACCAATCATATTTGATTATTTGACAAGTGTACTTCATAGGTAGTGAAGTGAGCTTTCCTCTGTAGGCAAGTGGTATCTTTTTGTGACCTTAGCAACCATAGATGAATGTCACCTAGACTCATTGTGTCACTAGGGATGGCCTTGAGGTTTCCTGTTCTATTTTCATTTACTAAGCATGCACTTTAGAAAGGCTCTGAGCTGCTCCCTGAAGCATGGCACCCGTCCTCCAGAAACCCGCAGTCTAGAGGTTGTAAAAGAAGATTTGAACACCAAGACTGTAAAAGATGATTTGAACAACAACAACAACAACAAAGCAGTTTTATTTTGTATACATTCTTTCATTGTACCTCCCCCAGAGGGATATAACCTCCAAATAGGGGAGCCATACCATAGATGCATTAAATTCACACCAATTCAAATGTGTGTATATATGTATTTGCTTGCAGACTACTAAAGTGACAATGTAAACGTTGCTGCCTATTTTTCCCACTCTTCTATTAGATTGACGTTGCTTTTGGTGAGATGGGGCATGAGTCCACCATCCTGTCCCCTCTGTTTCCACATGACCCTCATCGTATGAACACCTCTCTTAAGTGTGATTCTAGGATTTAAAGATACATATTTCTTATGCATTATGCACCTAAACACAAGCCAACTACTTCATCTGGCACCTGATCCAAGAAACAACATTCTGTTCCAAAATCAATAGAAGACAAGGCACTTTAAGGGATCTTCAAGGGAGTGTAATTTTGAGCATATGGAATCTTTCTAACCCTAGCTAACTTTAGAAGTTTAACTCCTATGCAAGATGAAGCATCTATGTTCCCAAGAGTTTGACTTCAGCAAAGGACAAGCTGCAGAAGCTGACATTATTGTTTATTTTGGCATAAAGGCTTTACTTGTTGGTGAAGTTCAAGTTTAATGATCTCTTCCTCCCTTTCTCTCTCTTCCTCCTCTCCGCTTTCCTTCTTCCCTTCCTCCCACCCTGATTTTCTCTTTTGCAGTTTGCTGCTTTGTGGTGCACAAGCGGTGCCATGAATTTGTCACATTCTCCTGCCCTGGCGCTGACAAGGGTCCAGCCTCCGATGTAAGTAATGGGCATCGATTGCTTTTCTCTGTCCACAGTCAATGCTGCCTTGTGATTAAATGTGAGTGAGCATTCTTAGACGAGTAAGTGTGGACGATCTCACTCTAAGGCATGTGGTGGTCCCTATAGCTTTTGAGACAGTTTTCCTTTTAGTGGAAAACAAAATTTTGGAGGGAGTGTGGCTGGATAGGAAGTCAGCTAGTTTGTCTACTATGATTTTGCTAATGTCTTCACTTTGAGAGCTGGAGCACGGAGGGTGAGAGGCAGGGGCCTACTTGGTAGTGTGGCTGCAAAAAGGTAGTTTCGGTGGTACTTTGCAGTGCACGTTATGGCACTTTGTTAGGGTGTTCTTTCTTTTGTTATTGTTATTATTATTTTTATTATTTTTCAGATGGAGTCTTGCTCTATCGCCCAGGCTGGAGTGCAGTGGAGCAATCTCAGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGGAGCTGGGACTACAGGCACCTGCCACTATGCCTGGCTAATTTTTTGTTTTGTATTTTTGGTAGAGACGGGGTTTCACCGTGTTAGACAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGTCACTGTGCCCGGCCTATTATTATTATTATTTAAGAGTGTTGCCCAGGCTGGTCTCAAATTCCTGGGCTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTGGGATTCCAGGCGTGAGCCAGTGCACCCTGCTTGTTAGGGTGTTCCTAATATCAGGGCCCAGGAATGAGGAGGAAATGAATTTATCCTGCTACCATGAATCTCAAAGTATGACTACTGCTAGTGGGACAAGAGATGCTTGTAGGTAAAATGTGCAAAAAATTTTTGTTTTAATCATTATAAATGTATTTTAATGTGGATTGGGAAAAATGTATCTAGTAGTGGTTTTGCATTTATGATAAGGATATAGAATTTCCTACCTAAGTAAAGATTTTTAGGTTAAACAAAAGATAAACTGATTTGAGGACAATATTAAGTGAATGACAGTATGGGTGATATAAGGATATGGCAAAAGTTTTGGTACAAATGTGTTTAAAGTTTAGGGTACATTGTTGATTGGCCTACCCAGCAGCCATTCACAGCCTTCATCCTTCTGGCAGAGGCTACCTCTCATGATGGAAGCTAAAAATGCCTAATACTTGCTTTTCCCGGCTCTCTTGTAGCTGCTGAATGAGGATGTGACCCAATCCTGCTAATGGGAACTGAGGGGAAGACCTGGGAAAGAGTCTAGGAAAGATTTTTCCTTTCTGATAAGAGAGAGACATCCCTTCCCTTGTCCTCTTGGGCATTTTTGTACAAGGATATAATGCTTGGAGTTGTGGCAGCCCTTTTGGGTCAATGAGGGACACATTGCCGACATCCTGAGCATGGCAGAGTGGAAAACTTAAAAGAACCGTGGGTCCATGATGATGCTGATGAGCTGTTGATACCACTCACAGTCCTTTTATCCCCAAGCTGGATAGATGGGAGAAGAAGCTTTTTTTTTGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGGTCAGGAGATCGAAACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGTGGGCGCCTGTAGTCCTAGCTCCTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCAGAGCTTGCAGTAAGCGGAGATCGCACCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCGAAAAAAAAGAAAAAAAAGAAGCTTTTTTTTTTTTTTTCTTTTTTTTTTTAAGCAAAGTCTTACTCTTTGAAGCCTTCTCTTTTATTTTTGTTTTTTTCTCTTTTGAGACAGAATCTTGCTCTGTTGCCCAGGCCAGAGTGTGGTGGCATGATCATGTCTCACTCAC
GATGTGAGCCACCACACCCGGTTTCTATTCTTATTTTTAATACTTAATTGTTAACACGTATATTTAAACTTATAATGTCCTATATGCAATTTCTCAATATCAATAATCTTTTGAGGAATATAAGACTCAGCACATTTTCATCTTGTAACCCTCCTGCAACTCCCATTTCTTATGACTTGGGTTTTCTCTACTTCTCTATCTCTTCCTCTGTTGAAAACTTTTCATATTATGGAAAAAATTAAACATATATAAAAGTAACATTAGTATAATGCATCCTTGTGTATGCATCACCCAGTTCAATAATGACCCATCATGATCAATTTCTTTTTCATCTGTAATCCTCCCCTTTCTCTCCCCACCTTGGCATACTGAATTATTTTAAATTATTTTATCCATAAAGATGTTAATGTATCCTCAAAGATAAGGATTCTATAAGCAAAGAAAAACAAGACCATTATCACACCAAATATTTTTCATTCCCTAATATCAGTAACAATAATTCCCTTATGTCATCAGAAAGTGAGTATATCCATTTCCCTGATTGCCTTACAGTTTTTTAAACTGTTGGTTTTTTTCCACTTAGAATCCAAACAAGGTCCACATGTTAAATTTAGTTGATATGGGTTGATAGGTGCAGCAAACCACCATGGCACATGTATACCTGTGTAACAAACCTGAATGTTCTGCACGTGTATCCCAGAATTTAAAGTAAAATTAAAAAAATTTAGTTGATATGTTTCTTAAATTCCTTTGAAAATATACGTTTCTCGTCCTATTTTCTCCCCACTTGCAGTCCTCTCTTGTAGTCTATTTGTTGAAGATACCATATTCTTTGCCTTGTAGTTTTCTACATTCTGGGTATTTGGTTGGGGTGGGGGGGGGTGTGTTTGCTGATCGCATCCCTGTGGTGTCATTTAATATGTTCCTCTGTCACTTGTATTTTCTGTAAATCTGTATTTGCATCAAGAGACTTGAACCAATCATATTTGATTATTTGACAAGTGTACTTCATAGGTAGTGAAGTGAGCTTTCCTCTGTAGGCAAGTGGTATCTTTTTGTGACCTTAGCAACCATAGATGAATGTCACCTAGACTCATTGTGTCACTAGGGATGGCCTTGAGGTTTCCTGTTCTATTTTCATTTACTAAGCATGCACTTTAGAAAGGCTCTGAGCTGCTCCCTGAAGCATGGCACCCGTCCTCCAGAAACCCGCAGTCTAGAGGTTGTAAAAGAAGATTTGAACACCAAGACTGTAAAAGATGATTTGAACAACAACAACAACAACAAAGCAGTTTTATTTTGTATACATTCTTTCATTGTACCTCCCCCAGAGGGATATAACCTCCAAATAGGGGAGCCATACCATAGATGCATTAAATTCACACCAATTCAAATGTGTGTATATATGTATTTGCTTGCAGACTACTAAAGTGACAATGTAAACGTTGCTGCCTATTTTTCCCACTCTTCTATTAGATTGACGTTGCTTTTGGTGAGATGGGGCATGAGTCCACCATCCTGTCCCCTCTGTTTCCACATGACCCTCATCGTATGAACACCTCTCTTAAGTGTGATTCTAGGATTTAAAGATACATATTTCTTATGCATTATGCACCTAAACACAAGCCAACTACTTCATCTGGCACCTGATCCAAGAAACAACATTCTGTTCCAAAATCAATAGAAGACAAGGCACTTTAAGGGATCTTCAAGGGAGTGTAATTTTGAGCATATGGAATCTTTCTAACCCTAGCTAACTTTAGAAGTTTAACTCCTATGCAAGATGAAGCATCTATGTTCCCAAGAGTTTGACTTCAGCAAAGGACAAGCTGCAGAAGCTGACATTATTGTTTATTTTGGCATAAAGGCTTTACTTGTTGGTGAAGTTCAAGTTTAATGATCTCTTCCTCCCTTTCTCTCTCTTCCTCCTCTCCGCTTTCCTTCTTCCCTTCCTCCCACCCTGATTTTCTCTTTTGCAGTTTGCTGCTTTGTGGTGCACAAGCGGTGCCATGAATTTGTCACATTCTCCTGCCCTGGCGCTGACAAGGTTCCAGCCTCCGATGTAAGTAATGGGCATCGATTGCTTTTCTCTGTCCACAGTCAATGCTGCCTTGTGATTAAATGTGAGTGAGCATTCTTAGACGAGTAAGTGTGGACGATCTCACTCTAAGGCATGTGGTGGTCCCTATAGCTTTTGAGACAGTTTTCCTTTTAGTGGAAAACAAAATTTTGGAGGGAGTGTGGCTGGATAGGAAGTCAGCTAGTTTGTCTACTATGATTTTGCTAATGTCTTCACTTTGAGAGCTGGAGCACGGAGGGTGAGAGGCAGGGGCCTACTTGGTAGTGTGGCTGCAAAAAGGTAGTTTCGGTGGTACTTTGCAGTGCACGTTATGGCACTTTGTTAGGGTGTTCTTTCTTTTGTTATTGTTATTATTATTTTTATTATTTTTCAGATGGAGTCTTGCTCTATCGCCCAGGCTGGAGTGCAGTGGAGCAATCTCAGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGGAGCTGGGACTACAGGCACCTGCCACTATGCCTGGCTAATTTTTTGTTTTGTATTTTTGGTAGAGACGGGGTTTCACCGTGTTAGACAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGTCACTGTGCCCGGCCTATTATTATTATTATTTAAGAGTGTTGCCCAGGCTGGTCTCAAATTCCTGGGCTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTGGGATTCCAGGCGTGAGCCAGTGCACCCTGCTTGTTAGGGTGTTCCTAATATCAGGGCCCAGGAATGAGGAGGAAATGAATTTATCCTGCTACCATGAATCTCAAAGTATGACTACTGCTAGTGGGACAAGAGATGCTTGTAGGTAAAATGTGCAAAAAATTTTTGTTTTAATCATTATAAATGTATTTTAATGTGGATTGGGAAAAATGTATCTAGTAGTGGTTTTGCATTTATGATAAGGATATAGAATTTCCTACCTAAGTAAAGATTTTTAGGTTAAACAAAAGATAAACTGATTTGAGGACAATATTAAGTGAATGACAGTATGGGTGATATAAGGATATGGCAAAAGTTTTGGTACAAATGTGTTTAAAGTTTAGGGTACATTGTTGATTGGCCTACCCAGCAGCCATTCACAGCCTTCATCCTTCTGGCAGAGGCTACCTCTCATGATGGAAGCTAAAAATGCCTAATACTTGCTTTTCCCGGCTCTCTTGTAGCTGCTGAATGAGGATGTGACCCAATCCTGCTAATGGGAACTGAGGGGAAGACCTGGGAAAGAGTCTAGGAAAGATTTTTCCTTTCTGATAAGAGAGAGACATCCCTTCCCTTGTCCTCTTGGGCATTTTTGTACAAGGATATAATGCTTGGAGTTGTGGCAGCCCTTTTGGGTCAATGAGGGACACATTGCCGACATCCTGAGCATGGCAGAGTGGAAAACTTAAAAGAACCGTGGGTCCATGATGATGCTGATGAGCTGTTGATACCACTCACAGTCCTTTTATCCCCAAGCTGGATAGATGGGAGAAGAAGCTTTTTTTTTGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGGTCAGGAGATCGAAACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGTGGGCGCCTGTAGTCCTAGCTCCTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCAGAGCTTGCAGTAAGCGGAGATCGCACCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCGAAAAAAAAGAAAAAAAAGAAGCTTTTTTTTTTTTTTTCTTTTTTTTTTTAAGCAAAGTCTTACTCTTTGAAGCCTTCTCTTTTATTTTTGTTTTTTTCTCTTTTGAGACAGAATCTTGCTCTGTTGCCCAGGCCAGAGTGTGGTGGCATGATCATGTCTCACTCAC
Task1_train_22497
This is a variant in IL21R (interleukin 21 receptor), located on Chromosome 16. Is this mutation a likely cause of disease or not?
Pathogenic; Cryptosporidiosis-chronic cholangitis-liver disease syndrome
TCCTGACCTCGTGACCCACCTGCCTTGGCCTTCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCCAGCCAGACTGTTTTATTTCGTCACAGTCCCTAAACCTGCTTCACTCCTCTCTGTGACCTGCCCGCCCCTGAGTTTGCAATCCTGATCAGGTCTAAATCTCCCAGGTCCCAGATGAATAAACTGAAGCCCAGAGTTGGGAGTACTTTGCCCAAAGTCACTCAGGGTTGTTGGTCTTCATCTCATCCATGATGGGTCAGGCATGGAGGCAGGGGTGGGGGCAGGCAGGACTTCCTCCCATCACCAAATCCTTTTCACCTGCAGCAAATTCTCACCCCATTTTCTTTTCCTGGGTTTTTCCACCAAGTCAAGCCGGCTCCCCCTTTCAACGTGACTGTGACCTTCTCAGGACAGTATAATATCTCCTGGCGCTCAGATTACGAAGACCCTGCCTTCTACATGCTGAAGGGCAAGCTTCAGTATGAGCTGCAGTACAGGAACCGGGGAGACCCCTGGGCTGTGGTGAGGAATGTGGGGATCAGTGCAGCTTTGTGGGAGGGGAGGGGAGATGACGGAGTGCAAAGGCATCTGGGTGGGAGAGACGGGTGAACAACATCATTCATGGCCAAGAACAGAGACCAAGGGCACGAGCACTCCCTTACAGCGGGCCCTCCTCCTCCCCTCACTTCTCCCCAAGGTAGGAGACCCCTGAATAATCTGTCCTCCCCAAACTGGTCTCCTCGGCGGTCAGCATGCCAAAGAGACTGTCCCTTCCCCAGACTCCACCCCAGGTCTAGCATAGTCACAATAGAAGAAGTTTCAGAAATGGGGCAACCTGGAAGCTTCCCAATTGCTTAGAATGGCCATAGTTGGAGAGTTCCAGAAATATCAATTATTAAGAAGGTCCAGCCAGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGAGGCCAAGGCAGGTGGATCTCTTGAGGTCAGGAGTTTGAGACCAGCCAGGGCAACATGGTGAAACTCTGTTTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACATGCACCTGTAATCCAGCTATTCTGGAGGCTTAGGCAGGAGAATCACTTGAATCCAGGAGGCGGAGGTTGCAGTGAGCTGGGATCGCGCTACTGCACTCTAGCCTGGGCAACAGAGTGAGACTCGATCTCAAAAAAAAAAAAAAGGTCCAGTGTTAGAGGGCCCATTGTTTCAAACATGAAGGTGTTGAGTGATGTCCTTCCAGCCCACTATTTAGAACAGTCACAAGTGATGTACTGTCTCTAAAAAATAAAAAATAGTAACAATGATAGAACAGTCACAGCTGAAGAGTTCTAGAATTGCCCATCCTTTAGGATAGTCCCAGCTGAAGATGTCCATGAGTGCCATACTTTAGAAAGTCCCCAGTGGAAGACTTCCAGAGGTATCCATTGCTAAGATGTCTGTAGTTAGAGTTCTAGAAATGCCTGCTGTTGGGAATGTCAGTATGTCAACTCTTGGAATTCTTCAACAGTTGAAGACATTCTCCACTGATGTACTGAGACTTATATCAGTAGTACATCGGTTGAGAATGTCCTCAACTGTTGAAGAATTCCAAAAGTATGCATTGCCTGGAATGCTGCCAGACCATTACCACTCCTGAGATATGCCCAGTCCTGCAGGGAGAGTCCACTGCCAGGACTGTGAGTGGCTGAATTGGATCAAAGAGAAATCAAACAGAGCATCCTATCACATGCACGGGCCAGGCAGTGCTGGTGAGTCTGTGCTCCCCATGCCTGAGTCCAGCTACTCAGGCATAGGCTTGATTCTTGTGGGAAGAGAAGAGACACTCAGCCCCTTTGATGGAAGCTGGGAAAAGAGGTGGCTCTGCTGGAGGCAGGGGCTGGCCTGGTTTAACCCTGACCTGGTGCATCCTTTCCTTGTACTGGCAGAGTCCGAGGAGAAAGCTGATCTCAGTGGACTCAAGAAGTGTCTCCCTCCTCCCCCTGGAGTTCCGCAAAGACTCGAGCTATGAGCTGCAGGTGCGGGCAGGGCCCATGCCTGGCTCCTCCTACCAGGGGACCTGGAGTGAATGGAGTGACCCGGTCATCTTTCAGACCCAGTCAGAGGGTAGGTGTGAAGCTGGGATGGACACCCCACTCCTGGTATCAAATTTTGTCCTGTTCTAGCCACCCTAAGCCCTGAGCTTTCTGGCACAGCTGGGAGGTATTCAGTTGTTCATCCTCAGATGTAGCCCTTCAATTACATTTCTAGAGCCCCTGCTGGCCAGGCCCTGTTGGGTGCCAGCTGCTTCTTCTGTTAGGCATTTGATCCCCCTAACTCTGAAGTGGGAATCAGCCCTGTTTTTCAGACGAGATAACTTAGGCTCAGAGAAATGAAGTTACTTGCCTGGGGTGAGGAATGAGAACAAGATTTGAACCCAGATCCATCTCACTTCAAGACACTAGCAGTAACAGCCTCTCCTACCCTCTTCCACTCTACCCCAGACCCATTTCCCACCATGCCCACCCCATATGGCCTCTGGTAGAGTTGGTGCCATTTAACCCTTTCTTTGCTTCCTTCCCAGAGTTAAAGGAAGGCTGGAACCCTCACCTGCTGCTTCTCCTCCTGCTTGTCATAGTCTTCATTCCTGCCTTCTGGAGCCTGAAGACCCATCCATTGTGGAGGTGAGGCCAGGGGATGAGGAAGGCAGGGAGGTGGTCAGCCTGGGCCACTGCCCCTGTATGATACATGCAGGGTTGGAAAACATGACTGTCATCATGGTAACAATGATGATGATGGGATAATAACCAACTCACAGCCACCATGTGCTGGACACTGTGGAGGGCACTCCCTTCACCCCCATGGCTGCCCTATGAGCTTGAGACACTGCAGTTGCCCTTATTTTACAAATGGAGAAACTGAGGCAAGGAGATGTCAAGGACAAAGTCACACAGCTCCAAGGTGGAGAAATTGGGATTGAAAATCTGTGCCCTTAAACAGGGACCTCAGCTGTGATCTTGTCCAGTGGATTTTAAGCTTTGAGGCTTAATGGGCTTAAGGGGCCACTAGGTGGTGGTGAAGAGGTGGCTGTAATAGTCCACACCTCTGAAATGGCCTCTCTGCGCACCCCTGGTTGCAGATAAAGAAGTTGAGGCTCAGAAGGGGCAACATTTGCCCAGCACGCAACAGGCAGCCAAGAACATAACCACGATATCCCTTCAGGAGCCTGTGAGGGAGACTTACTTCTCCCATTTTACAGAAGGGGAAACCAAGCCCCAGGGAAGGAGGGAGGCGCCTGGGCTGAGTCTTGGGATGCTCGGAAGCTCCTGTAGGATGAAGCTGGGGAGCGTCCGAATGGGAGGCCAGGCTGCCCTCTGGTGATGTCAGGGTCCTCACCCCTCTCTGCCCCCTCAGGCTATGGAAGAAGATATGGGCCGTCCCCAGCCCTGAGCGGTTCTTCATGCCCCTGTACAAGGGCTGCAGCGGAGACTTCAAGGTGAGCTCCCGACCCTGTGATGAGCTCCTCGGAGCCCCTCCTCCTCTTCAGGAGCCCCACCTCCCCTCACCCCAGGCTCCCCAGCCTCACCCCACAGGCCTAGAGCATCCAGGTCTCAGCCAAGCCACAAGCCAGGCCTCAGTTTCCCCATGTGCAAAGTGTAGACAGTCATTCTTGTGGTGCAGAATTGGCAGAAGAATTAAACAAGATTTGACCAGGTGTGGTGGCTGACATCTGCAATCCCAGCACTTTGGGAGGCCAAAGCAAGTGGACTGCTTGAGGCCAGGAGTTCAAAAACAGCCTGGGCAACATAGGGAGACCCTCACCACCACTCCGCCTCCCCATCTCTACCAAAAACTTAAAAATCATTCAAGTGAGGTGGTGCACGCCTGTAGTCCCAGCAACTCGGGAGGCTGAGGCAGGACGATCGTTCAGAGGCTGCCGTGAGCTATGATCACACCACTGCCCTCCAGCCTGGCCAACAGACAGAGACTATATCTTAAAAAAAAAAAAATCAAAAAGAAAAAGTAAACAAAATAATGCAGCATTGGCCCAGCCCAAGGAACCAGACTGGGATAGGGGGTGAGGCTGGTGG
TCCTGACCTCGTGACCCACCTGCCTTGGCCTTCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCCAGCCAGACTGTTTTATTTCGTCACAGTCCCTAAACCTGCTTCACTCCTCTCTGTGACCTGCCCGCCCCTGAGTTTGCAATCCTGATCAGGTCTAAATCTCCCAGGTCCCAGATGAATAAACTGAAGCCCAGAGTTGGGAGTACTTTGCCCAAAGTCACTCAGGGTTGTTGGTCTTCATCTCATCCATGATGGGTCAGGCATGGAGGCAGGGGTGGGGGCAGGCAGGACTTCCTCCCATCACCAAATCCTTTTCACCTGCAGCAAATTCTCACCCCATTTTCTTTTCCTGGGTTTTTCCACCAAGTCAAGCCGGCTCCCCCTTTCAACGTGACTGTGACCTTCTCAGGACAGTATAATATCTCCTGGCGCTCAGATTACGAAGACCCTGCCTTCTACATGCTGAAGGGCAAGCTTCAGTATGAGCTGCAGTACAGGAACCGGGGAGACCCCTGGGCTGTGGTGAGGAATGTGGGGATCAGTGCAGCTTTGTGGGAGGGGAGGGGAGATGACGGAGTGCAAAGGCATCTGGGTGGGAGAGACGGGTGAACAACATCATTCATGGCCAAGAACAGAGACCAAGGGCACGAGCACTCCCTTACAGCGGGCCCTCCTCCTCCCCTCACTTCTCCCCAAGGTAGGAGACCCCTGAATAATCTGTCCTCCCCAAACTGGTCTCCTCGGCGGTCAGCATGCCAAAGAGACTGTCCCTTCCCCAGACTCCACCCCAGGTCTAGCATAGTCACAATAGAAGAAGTTTCAGAAATGGGGCAACCTGGAAGCTTCCCAATTGCTTAGAATGGCCATAGTTGGAGAGTTCCAGAAATATCAATTATTAAGAAGGTCCAGCCAGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGAGGCCAAGGCAGGTGGATCTCTTGAGGTCAGGAGTTTGAGACCAGCCAGGGCAACATGGTGAAACTCTGTTTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACATGCACCTGTAATCCAGCTATTCTGGAGGCTTAGGCAGGAGAATCACTTGAATCCAGGAGGCGGAGGTTGCAGTGAGCTGGGATCGCGCTACTGCACTCTAGCCTGGGCAACAGAGTGAGACTCGATCTCAAAAAAAAAAAAAAGGTCCAGTGTTAGAGGGCCCATTGTTTCAAACATGAAGGTGTTGAGTGATGTCCTTCCAGCCCACTATTTAGAACAGTCACAAGTGATGTACTGTCTCTAAAAAATAAAAAATAGTAACAATGATAGAACAGTCACAGCTGAAGAGTTCTAGAATTGCCCATCCTTTAGGATAGTCCCAGCTGAAGATGTCCATGAGTGCCATACTTTAGAAAGTCCCCAGTGGAAGACTTCCAGAGGTATCCATTGCTAAGATGTCTGTAGTTAGAGTTCTAGAAATGCCTGCTGTTGGGAATGTCAGTATGTCAACTCTTGGAATTCTTCAACAGTTGAAGACATTCTCCACTGATGTACTGAGACTTATATCAGTAGTACATCGGTTGAGAATGTCCTCAACTGTTGAAGAATTCCAAAAGTATGCATTGCCTGGAATGCTGCCAGACCATTACCACTCCTGAGATATGCCCAGTCCTGCAGGGAGAGTCCACTGCCAGGACTGTGAGTGGCTGAATTGGATCAAAGAGAAATCAAACAGAGCATCCTATCACATGCACGGGCCAGGCAGTGCTGGTGAGTCTGTGCTCCCCATGCCTGAGTCCAGCTACTCAGGCATAGGCTTGATTCTTGTGGGAAGAGAAGAGACACTCAGCCCCTTTGATGGAAGCTGGGAAAAGAGGTGGCTCTGCTGGAGGCAGGGGCTGGCCTGGTTTAACCCTGACCTGGTGCATCCTTTCCTTGTACTGGCAGAGTCCGAGGAGAAAGCTGATCTCAGTGGACTCAAGAAGTGTCTCCCTCCTCCCCCTGGAGTTCCGCAAAGACTCGAGCTATGAGCTGCAGGTGCTGGCAGGGCCCATGCCTGGCTCCTCCTACCAGGGGACCTGGAGTGAATGGAGTGACCCGGTCATCTTTCAGACCCAGTCAGAGGGTAGGTGTGAAGCTGGGATGGACACCCCACTCCTGGTATCAAATTTTGTCCTGTTCTAGCCACCCTAAGCCCTGAGCTTTCTGGCACAGCTGGGAGGTATTCAGTTGTTCATCCTCAGATGTAGCCCTTCAATTACATTTCTAGAGCCCCTGCTGGCCAGGCCCTGTTGGGTGCCAGCTGCTTCTTCTGTTAGGCATTTGATCCCCCTAACTCTGAAGTGGGAATCAGCCCTGTTTTTCAGACGAGATAACTTAGGCTCAGAGAAATGAAGTTACTTGCCTGGGGTGAGGAATGAGAACAAGATTTGAACCCAGATCCATCTCACTTCAAGACACTAGCAGTAACAGCCTCTCCTACCCTCTTCCACTCTACCCCAGACCCATTTCCCACCATGCCCACCCCATATGGCCTCTGGTAGAGTTGGTGCCATTTAACCCTTTCTTTGCTTCCTTCCCAGAGTTAAAGGAAGGCTGGAACCCTCACCTGCTGCTTCTCCTCCTGCTTGTCATAGTCTTCATTCCTGCCTTCTGGAGCCTGAAGACCCATCCATTGTGGAGGTGAGGCCAGGGGATGAGGAAGGCAGGGAGGTGGTCAGCCTGGGCCACTGCCCCTGTATGATACATGCAGGGTTGGAAAACATGACTGTCATCATGGTAACAATGATGATGATGGGATAATAACCAACTCACAGCCACCATGTGCTGGACACTGTGGAGGGCACTCCCTTCACCCCCATGGCTGCCCTATGAGCTTGAGACACTGCAGTTGCCCTTATTTTACAAATGGAGAAACTGAGGCAAGGAGATGTCAAGGACAAAGTCACACAGCTCCAAGGTGGAGAAATTGGGATTGAAAATCTGTGCCCTTAAACAGGGACCTCAGCTGTGATCTTGTCCAGTGGATTTTAAGCTTTGAGGCTTAATGGGCTTAAGGGGCCACTAGGTGGTGGTGAAGAGGTGGCTGTAATAGTCCACACCTCTGAAATGGCCTCTCTGCGCACCCCTGGTTGCAGATAAAGAAGTTGAGGCTCAGAAGGGGCAACATTTGCCCAGCACGCAACAGGCAGCCAAGAACATAACCACGATATCCCTTCAGGAGCCTGTGAGGGAGACTTACTTCTCCCATTTTACAGAAGGGGAAACCAAGCCCCAGGGAAGGAGGGAGGCGCCTGGGCTGAGTCTTGGGATGCTCGGAAGCTCCTGTAGGATGAAGCTGGGGAGCGTCCGAATGGGAGGCCAGGCTGCCCTCTGGTGATGTCAGGGTCCTCACCCCTCTCTGCCCCCTCAGGCTATGGAAGAAGATATGGGCCGTCCCCAGCCCTGAGCGGTTCTTCATGCCCCTGTACAAGGGCTGCAGCGGAGACTTCAAGGTGAGCTCCCGACCCTGTGATGAGCTCCTCGGAGCCCCTCCTCCTCTTCAGGAGCCCCACCTCCCCTCACCCCAGGCTCCCCAGCCTCACCCCACAGGCCTAGAGCATCCAGGTCTCAGCCAAGCCACAAGCCAGGCCTCAGTTTCCCCATGTGCAAAGTGTAGACAGTCATTCTTGTGGTGCAGAATTGGCAGAAGAATTAAACAAGATTTGACCAGGTGTGGTGGCTGACATCTGCAATCCCAGCACTTTGGGAGGCCAAAGCAAGTGGACTGCTTGAGGCCAGGAGTTCAAAAACAGCCTGGGCAACATAGGGAGACCCTCACCACCACTCCGCCTCCCCATCTCTACCAAAAACTTAAAAATCATTCAAGTGAGGTGGTGCACGCCTGTAGTCCCAGCAACTCGGGAGGCTGAGGCAGGACGATCGTTCAGAGGCTGCCGTGAGCTATGATCACACCACTGCCCTCCAGCCTGGCCAACAGACAGAGACTATATCTTAAAAAAAAAAAAATCAAAAAGAAAAAGTAAACAAAATAATGCAGCATTGGCCCAGCCCAAGGAACCAGACTGGGATAGGGGGTGAGGCTGGTGG
Task1_train_22498
A variant found in Chromosome 16 affects CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Neuronal ceroid lipofuscinosis 3
GTACAGTACTGCAATCTCGGCTCACTGCAACCTCCATATCCGGAGTTCAAGCAATTCTCCTGCCTCAGCCTAGCGAGTAGCTGAGATGACAGGCAGGTGCCACCACGCCCAACTAATTTTTGCATTTTTAATAGAGACGGGGTTTCACTGTGTTGGCCAGACTGGTCTCAAACTCCTGATCCTGACCTCAGGTGATTCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCAGGACTGGCCAAGTTCCTAAATTTCAAAGGCAGAAGACTTTCCTGTCACAGTTGACAGTTTATTGTAACAGTTACCTGCAGGGGCTGTGGATTTGTAACCTTGAAACAATGAATGCTGGTTATATGAAACTCCTTTTATTAGACTGTTGTAAGGAAGGGTGTTTGCGCCCTTAAAGCTGTAAACTACTGTTTGCCAAGGGCAGTTGAATTTGCTCACCACCCTCAAGATAAATAACCCACTGACTTCAAAGTCACCAATTCTATTATAATTAACTATCTAGAATAAAAGAACTGTACATTTTCTTATAGTTAGAAACATTATTTGAAAGCCTGTCTCTTTGCCTGAGGTAAATGACCTATGATCATGCCACTGTACTCCAGCCTAGGCGACAGAGGAAGGTTCCGACTTTTCCTTTCTTTTTTCTTTTTCTGGGAGACAGGGTCTCGCTCTATTGCCTAGGCTGGAGTGCAGTGGCATGACCTTGGTTACTGCAGCCTTGACCTCATGGGTTCAAGTGATCCTCCCACCTCAGCTTCCCAGTAGCTAAGACTACAGGTGTGCGCCACTGCACCTGGCTAATTTTTGTAGAGATGTGATTGTGCCATGTTGCCCAGGCTGGACTTGAACTACCAAGCTCAAATGATCCACCTGCCTCAGCCTCCCATAGTGCTGGGATTACAGGCATGAGCCACCTGGCCCGGCCCAATCCCAATGCTTAAAACACACACACACACACACACACACACACACACACACGCACACACACACACACACACACTACAAAATCTTGTTCTTCGATTCTTTCTCTCATCTCTATTTCTTACAACTACCCTGAAAAATAGGTATTGGCCACACCCAATTTATACATGAGGAAATTGAGGCTCAGAGAGGTTCTGAGACCTGCCCTAAGTCACACAGTGGCTGAGTACTGAAGCTCAGTTTTGCTTGGCTCCTGAGGCTATACATTTTACATGGAGCTCTGCTGGACTTTGGTTCCCTGTGCTAAGAAATGATAGTGTACAATTTACACTTCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCCGGCAGATCACCTGAGGTCAAGAGTTCAAGACCAGCCAATATGGCAAAATCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTATGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGACTGAGGCAGGAGAGTCACTTGAACCCGGGAGGCAGAGGTTGCAGTAAGCCAAGATTGCGCTACTGCACTCCAGCCTGGACGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAATTTACACTTCCCACTGATAGTGGGAAGCAGGGGGTTTGGGGAAGCTGGGAGCCAAGCTGGGAGCCAAGGTGGGAGTGAAGTGAGGGGCAGGGGTTTGGTACCTGCAGCAGGGCCAGGGCCCAGGTGAAACGGATGCGACAGCAGCGGAGAGAAGAGCGGGAGGCAAAGACGCCAGCCTGGTACAGCATCTGGTACCTGAGGTTAGGGTTGGGGGGAGGAGAGGAGGCTCCTCCAGGGACCATCCCGCTCCCCCCGGTGCCTACTGGGCAGGGCAGCTGCATCACCACGGCGCCCTCCCAGCCCACTGCCCTCGCTCCTCTTACCAGCGGTATTGCTGAGCGTGACTCAGGGAAGTGTTCCAGAAAAAGAGGAGTTCAAACTGCAACAAATACCAGACAGGGGAGATGGACGGGGCTGTGTGGGTCCCAGCCCCAATCGCCACCTCCACACCCCTCCTAGCACCCCTCACTTACAAGTCCCTGGTTAATGAAATACTCGGCAAAGTAAACTACGACCAAGGGAACAATGTACCACAGCAGACCCTGGAAAAGGCAGAAGATATAAGCGGGGGGCCTGGAGGTGAGCAAGCCCCACAGGGACATACCCCAGCCATCATCCGAACCTTGAACACTGTCCACCTTTCCCGAAGGGAGAGGCTGGAGCTGGAGCCTGCAGGGGAACAGAGAGAGAAGGGCAGATGAAGTTTTCACACTGAAGACTCGGCAAAGAGGCACCGGTATGACAGAATTAACCAGACCACGCAACAGTGGGAACTCACTTCCATGCCACTGGATTGGACACTTAAAAATGGTTAAAATGGCTGGGCGCAGTGGCTCATGCTTGTAATCCCAGCACCTTGGGAGACTGAGGTGGGCGGATCACCTGAGGTCAGGAGTTCAAGACCACCCTGGCCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCATGTGTGGTGGCAGGTGTCTGTAGTCCCAGCTACTCGGGTGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGTAGTGAGCTGAGATTGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCACCTCAAAAAAATAAAGTAAGATAAAAAATAATAAAATGGTAAACTTCAAGTAATATACATACTTTATCATGATGAAAATAAAAGCTAACCAGGTGAGACCTCTTCACGTCTCTTTGATTTTTAATTTTTTTTATTTTTTGAGACAGAGTCTCACTCAGTTGCCCAGGCTGCAGTGCAGTGGTGCAATCTCAGCTCACTGCAGCCTCTGCCTCCTGGGTTCAAGTGATTCTCGTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCACCACCACACCTGGCTAATTTTTTTATTTTTAGTAGAGACGGGGTTTTACCATGTTGGCCAGACTGGTCTCAAACTCTTGATCTCAAATGATCCATCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTATGAACCACCACGCCCGGCCAATGTCTCTTGTACAGCTCCACAGATGGCCATTGGCCCACCCTGCCCAGTCTCACTGGCCATTCTCTGGTTCTAGAACATCCCAGCTTATCCCCACCGCAGGGCCTCAGCACTTGTGATTGGAATGCCTGGCACATGGTAAGTACTCAATTAATATCCCTTCTTCTCTCCCTCCCTTCCTTCCTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTGCGACAAGGTCTTGCTCTGTTGCCCAGGCTGGACTCAGACTTCTGAGCTCAAGTGGTCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATATTACAGGCGTGAGCCACTGTGCTCGTCCTCAACAAGTATTTCTCAAATAGACAAAGGCTTTTCCCATAACCAGTACACTCACTCTCTTTCCCCTCTTAACTTTGCCTATTGCAGAGAGGAAAAGGCCAAACCCAGAGAGAAAGAAAGTGACCTCTCTGAGGGTCTGTGTCTCCTACCTGGCTTCGACTCCGGGGCCTCGGTTCTTATGAGGGGCTGCCGGGCTGCGCTCTCTGCTTCTTCTTCCCCTCCAGGGTCCTGGGCCTCAGGAGATGTGAGCAACAAGAAATAGCTAGGAGTAGGATGAAGGCAGGGTCAGAAAACCCTACTGGCTGGGAAGGTCCCCAGGGACCATCTAGGCCACTTTTCCCAGGGAACACCTCTACCTTTGAACACTTTCAAAGATGGGTAGCTCACTGCCTCTAAGGCTCCTACGCTGTGCGGGAGAGCTCCAATTGTGGACAAAGGCTTCTTTCTTTGGACCTGAATTTATCTCCTTATTCCTATTCATGGGCCTTCATTTTGTTTTGATTTTTTTCAGAGACAGGGTCTTTCTCCAGCATCCAGGCTGGAATGCAGTGGTGCAATCATAGCTCACTGCAGCCGCGACCTCCCAGGCTCAAGCAATCCTCCCGCCTCAGCCTCCCAAGTAGCGGGGACTACAGGCACGTGCCACCAAGCCCGCCTCATATTTTCCATTTTTTGTATAAATGGAGTCTCG
GTACAGTACTGCAATCTCGGCTCACTGCAACCTCCATATCCGGAGTTCAAGCAATTCTCCTGCCTCAGCCTAGCGAGTAGCTGAGATGACAGGCAGGTGCCACCACGCCCAACTAATTTTTGCATTTTTAATAGAGACGGGGTTTCACTGTGTTGGCCAGACTGGTCTCAAACTCCTGATCCTGACCTCAGGTGATTCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCAGGACTGGCCAAGTTCCTAAATTTCAAAGGCAGAAGACTTTCCTGTCACAGTTGACAGTTTATTGTAACAGTTACCTGCAGGGGCTGTGGATTTGTAACCTTGAAACAATGAATGCTGGTTATATGAAACTCCTTTTATTAGACTGTTGTAAGGAAGGGTGTTTGCGCCCTTAAAGCTGTAAACTACTGTTTGCCAAGGGCAGTTGAATTTGCTCACCACCCTCAAGATAAATAACCCACTGACTTCAAAGTCACCAATTCTATTATAATTAACTATCTAGAATAAAAGAACTGTACATTTTCTTATAGTTAGAAACATTATTTGAAAGCCTGTCTCTTTGCCTGAGGTAAATGACCTATGATCATGCCACTGTACTCCAGCCTAGGCGACAGAGGAAGGTTCCGACTTTTCCTTTCTTTTTTCTTTTTCTGGGAGACAGGGTCTCGCTCTATTGCCTAGGCTGGAGTGCAGTGGCATGACCTTGGTTACTGCAGCCTTGACCTCATGGGTTCAAGTGATCCTCCCACCTCAGCTTCCCAGTAGCTAAGACTACAGGTGTGCGCCACTGCACCTGGCTAATTTTTGTAGAGATGTGATTGTGCCATGTTGCCCAGGCTGGACTTGAACTACCAAGCTCAAATGATCCACCTGCCTCAGCCTCCCATAGTGCTGGGATTACAGGCATGAGCCACCTGGCCCGGCCCAATCCCAATGCTTAAAACACACACACACACACACACACACACACACACACACGCACACACACACACACACACACTACAAAATCTTGTTCTTCGATTCTTTCTCTCATCTCTATTTCTTACAACTACCCTGAAAAATAGGTATTGGCCACACCCAATTTATACATGAGGAAATTGAGGCTCAGAGAGGTTCTGAGACCTGCCCTAAGTCACACAGTGGCTGAGTACTGAAGCTCAGTTTTGCTTGGCTCCTGAGGCTATACATTTTACATGGAGCTCTGCTGGACTTTGGTTCCCTGTGCTAAGAAATGATAGTGTACAATTTACACTTCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCCGGCAGATCACCTGAGGTCAAGAGTTCAAGACCAGCCAATATGGCAAAATCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTATGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGACTGAGGCAGGAGAGTCACTTGAACCCGGGAGGCAGAGGTTGCAGTAAGCCAAGATTGCGCTACTGCACTCCAGCCTGGACGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAATTTACACTTCCCACTGATAGTGGGAAGCAGGGGGTTTGGGGAAGCTGGGAGCCAAGCTGGGAGCCAAGGTGGGAGTGAAGTGAGGGGCAGGGGTTTGGTACCTGCAGCAGGGCCAGGGCCCAGGTGAAACGGATGCGACAGCAGCGGAGAGAAGAGCGGGAGGCAAAGACGCCAGCCTGGTACAGCATCTGGTACCTGAGGTTAGGGTTGGGGGGAGGAGAGGAGGCTCCTCCAGGGACCATCCCGCTCCCCCCGGTGCCTACTGGGCAGGGCAGCTGCATCACCACGGCGCCCTCCCAGCCCACTGCCCTCGCTCCTCTTACCAGCGGTATTGCTGAGCGTGACTCAGGGAAGTGTTCCAGAAAAAGAGGAGTTCAAACTGCAACAAATACCAGACAGGGGAGATGGACGGGGCTGTGTGGGTCCCAGCCCCAATCGCCACCTCCACACCCCTCCTAGCACCCCTCACTTACAAGTCCCTGGTTAATGAAATACTTGGCAAAGTAAACTACGACCAAGGGAACAATGTACCACAGCAGACCCTGGAAAAGGCAGAAGATATAAGCGGGGGGCCTGGAGGTGAGCAAGCCCCACAGGGACATACCCCAGCCATCATCCGAACCTTGAACACTGTCCACCTTTCCCGAAGGGAGAGGCTGGAGCTGGAGCCTGCAGGGGAACAGAGAGAGAAGGGCAGATGAAGTTTTCACACTGAAGACTCGGCAAAGAGGCACCGGTATGACAGAATTAACCAGACCACGCAACAGTGGGAACTCACTTCCATGCCACTGGATTGGACACTTAAAAATGGTTAAAATGGCTGGGCGCAGTGGCTCATGCTTGTAATCCCAGCACCTTGGGAGACTGAGGTGGGCGGATCACCTGAGGTCAGGAGTTCAAGACCACCCTGGCCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCATGTGTGGTGGCAGGTGTCTGTAGTCCCAGCTACTCGGGTGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGTAGTGAGCTGAGATTGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCACCTCAAAAAAATAAAGTAAGATAAAAAATAATAAAATGGTAAACTTCAAGTAATATACATACTTTATCATGATGAAAATAAAAGCTAACCAGGTGAGACCTCTTCACGTCTCTTTGATTTTTAATTTTTTTTATTTTTTGAGACAGAGTCTCACTCAGTTGCCCAGGCTGCAGTGCAGTGGTGCAATCTCAGCTCACTGCAGCCTCTGCCTCCTGGGTTCAAGTGATTCTCGTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCACCACCACACCTGGCTAATTTTTTTATTTTTAGTAGAGACGGGGTTTTACCATGTTGGCCAGACTGGTCTCAAACTCTTGATCTCAAATGATCCATCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTATGAACCACCACGCCCGGCCAATGTCTCTTGTACAGCTCCACAGATGGCCATTGGCCCACCCTGCCCAGTCTCACTGGCCATTCTCTGGTTCTAGAACATCCCAGCTTATCCCCACCGCAGGGCCTCAGCACTTGTGATTGGAATGCCTGGCACATGGTAAGTACTCAATTAATATCCCTTCTTCTCTCCCTCCCTTCCTTCCTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTGCGACAAGGTCTTGCTCTGTTGCCCAGGCTGGACTCAGACTTCTGAGCTCAAGTGGTCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATATTACAGGCGTGAGCCACTGTGCTCGTCCTCAACAAGTATTTCTCAAATAGACAAAGGCTTTTCCCATAACCAGTACACTCACTCTCTTTCCCCTCTTAACTTTGCCTATTGCAGAGAGGAAAAGGCCAAACCCAGAGAGAAAGAAAGTGACCTCTCTGAGGGTCTGTGTCTCCTACCTGGCTTCGACTCCGGGGCCTCGGTTCTTATGAGGGGCTGCCGGGCTGCGCTCTCTGCTTCTTCTTCCCCTCCAGGGTCCTGGGCCTCAGGAGATGTGAGCAACAAGAAATAGCTAGGAGTAGGATGAAGGCAGGGTCAGAAAACCCTACTGGCTGGGAAGGTCCCCAGGGACCATCTAGGCCACTTTTCCCAGGGAACACCTCTACCTTTGAACACTTTCAAAGATGGGTAGCTCACTGCCTCTAAGGCTCCTACGCTGTGCGGGAGAGCTCCAATTGTGGACAAAGGCTTCTTTCTTTGGACCTGAATTTATCTCCTTATTCCTATTCATGGGCCTTCATTTTGTTTTGATTTTTTTCAGAGACAGGGTCTTTCTCCAGCATCCAGGCTGGAATGCAGTGGTGCAATCATAGCTCACTGCAGCCGCGACCTCCCAGGCTCAAGCAATCCTCCCGCCTCAGCCTCCCAAGTAGCGGGGACTACAGGCACGTGCCACCAAGCCCGCCTCATATTTTCCATTTTTTGTATAAATGGAGTCTCG
Task1_train_22499
Assess the clinical impact of this variant on gene CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin), found on Chromosome 16. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Retinal dystrophy
GTACAGTACTGCAATCTCGGCTCACTGCAACCTCCATATCCGGAGTTCAAGCAATTCTCCTGCCTCAGCCTAGCGAGTAGCTGAGATGACAGGCAGGTGCCACCACGCCCAACTAATTTTTGCATTTTTAATAGAGACGGGGTTTCACTGTGTTGGCCAGACTGGTCTCAAACTCCTGATCCTGACCTCAGGTGATTCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCAGGACTGGCCAAGTTCCTAAATTTCAAAGGCAGAAGACTTTCCTGTCACAGTTGACAGTTTATTGTAACAGTTACCTGCAGGGGCTGTGGATTTGTAACCTTGAAACAATGAATGCTGGTTATATGAAACTCCTTTTATTAGACTGTTGTAAGGAAGGGTGTTTGCGCCCTTAAAGCTGTAAACTACTGTTTGCCAAGGGCAGTTGAATTTGCTCACCACCCTCAAGATAAATAACCCACTGACTTCAAAGTCACCAATTCTATTATAATTAACTATCTAGAATAAAAGAACTGTACATTTTCTTATAGTTAGAAACATTATTTGAAAGCCTGTCTCTTTGCCTGAGGTAAATGACCTATGATCATGCCACTGTACTCCAGCCTAGGCGACAGAGGAAGGTTCCGACTTTTCCTTTCTTTTTTCTTTTTCTGGGAGACAGGGTCTCGCTCTATTGCCTAGGCTGGAGTGCAGTGGCATGACCTTGGTTACTGCAGCCTTGACCTCATGGGTTCAAGTGATCCTCCCACCTCAGCTTCCCAGTAGCTAAGACTACAGGTGTGCGCCACTGCACCTGGCTAATTTTTGTAGAGATGTGATTGTGCCATGTTGCCCAGGCTGGACTTGAACTACCAAGCTCAAATGATCCACCTGCCTCAGCCTCCCATAGTGCTGGGATTACAGGCATGAGCCACCTGGCCCGGCCCAATCCCAATGCTTAAAACACACACACACACACACACACACACACACACACACGCACACACACACACACACACACTACAAAATCTTGTTCTTCGATTCTTTCTCTCATCTCTATTTCTTACAACTACCCTGAAAAATAGGTATTGGCCACACCCAATTTATACATGAGGAAATTGAGGCTCAGAGAGGTTCTGAGACCTGCCCTAAGTCACACAGTGGCTGAGTACTGAAGCTCAGTTTTGCTTGGCTCCTGAGGCTATACATTTTACATGGAGCTCTGCTGGACTTTGGTTCCCTGTGCTAAGAAATGATAGTGTACAATTTACACTTCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCCGGCAGATCACCTGAGGTCAAGAGTTCAAGACCAGCCAATATGGCAAAATCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTATGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGACTGAGGCAGGAGAGTCACTTGAACCCGGGAGGCAGAGGTTGCAGTAAGCCAAGATTGCGCTACTGCACTCCAGCCTGGACGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAATTTACACTTCCCACTGATAGTGGGAAGCAGGGGGTTTGGGGAAGCTGGGAGCCAAGCTGGGAGCCAAGGTGGGAGTGAAGTGAGGGGCAGGGGTTTGGTACCTGCAGCAGGGCCAGGGCCCAGGTGAAACGGATGCGACAGCAGCGGAGAGAAGAGCGGGAGGCAAAGACGCCAGCCTGGTACAGCATCTGGTACCTGAGGTTAGGGTTGGGGGGAGGAGAGGAGGCTCCTCCAGGGACCATCCCGCTCCCCCCGGTGCCTACTGGGCAGGGCAGCTGCATCACCACGGCGCCCTCCCAGCCCACTGCCCTCGCTCCTCTTACCAGCGGTATTGCTGAGCGTGACTCAGGGAAGTGTTCCAGAAAAAGAGGAGTTCAAACTGCAACAAATACCAGACAGGGGAGATGGACGGGGCTGTGTGGGTCCCAGCCCCAATCGCCACCTCCACACCCCTCCTAGCACCCCTCACTTACAAGTCCCTGGTTAATGAAATACTCGGCAAAGTAAACTACGACCAAGGGAACAATGTACCACAGCAGACCCTGGAAAAGGCAGAAGATATAAGCGGGGGGCCTGGAGGTGAGCAAGCCCCACAGGGACATACCCCAGCCATCATCCGAACCTTGAACACTGTCCACCTTTCCCGAAGGGAGAGGCTGGAGCTGGAGCCTGCAGGGGAACAGAGAGAGAAGGGCAGATGAAGTTTTCACACTGAAGACTCGGCAAAGAGGCACCGGTATGACAGAATTAACCAGACCACGCAACAGTGGGAACTCACTTCCATGCCACTGGATTGGACACTTAAAAATGGTTAAAATGGCTGGGCGCAGTGGCTCATGCTTGTAATCCCAGCACCTTGGGAGACTGAGGTGGGCGGATCACCTGAGGTCAGGAGTTCAAGACCACCCTGGCCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCATGTGTGGTGGCAGGTGTCTGTAGTCCCAGCTACTCGGGTGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGTAGTGAGCTGAGATTGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCACCTCAAAAAAATAAAGTAAGATAAAAAATAATAAAATGGTAAACTTCAAGTAATATACATACTTTATCATGATGAAAATAAAAGCTAACCAGGTGAGACCTCTTCACGTCTCTTTGATTTTTAATTTTTTTTATTTTTTGAGACAGAGTCTCACTCAGTTGCCCAGGCTGCAGTGCAGTGGTGCAATCTCAGCTCACTGCAGCCTCTGCCTCCTGGGTTCAAGTGATTCTCGTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCACCACCACACCTGGCTAATTTTTTTATTTTTAGTAGAGACGGGGTTTTACCATGTTGGCCAGACTGGTCTCAAACTCTTGATCTCAAATGATCCATCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTATGAACCACCACGCCCGGCCAATGTCTCTTGTACAGCTCCACAGATGGCCATTGGCCCACCCTGCCCAGTCTCACTGGCCATTCTCTGGTTCTAGAACATCCCAGCTTATCCCCACCGCAGGGCCTCAGCACTTGTGATTGGAATGCCTGGCACATGGTAAGTACTCAATTAATATCCCTTCTTCTCTCCCTCCCTTCCTTCCTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTGCGACAAGGTCTTGCTCTGTTGCCCAGGCTGGACTCAGACTTCTGAGCTCAAGTGGTCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATATTACAGGCGTGAGCCACTGTGCTCGTCCTCAACAAGTATTTCTCAAATAGACAAAGGCTTTTCCCATAACCAGTACACTCACTCTCTTTCCCCTCTTAACTTTGCCTATTGCAGAGAGGAAAAGGCCAAACCCAGAGAGAAAGAAAGTGACCTCTCTGAGGGTCTGTGTCTCCTACCTGGCTTCGACTCCGGGGCCTCGGTTCTTATGAGGGGCTGCCGGGCTGCGCTCTCTGCTTCTTCTTCCCCTCCAGGGTCCTGGGCCTCAGGAGATGTGAGCAACAAGAAATAGCTAGGAGTAGGATGAAGGCAGGGTCAGAAAACCCTACTGGCTGGGAAGGTCCCCAGGGACCATCTAGGCCACTTTTCCCAGGGAACACCTCTACCTTTGAACACTTTCAAAGATGGGTAGCTCACTGCCTCTAAGGCTCCTACGCTGTGCGGGAGAGCTCCAATTGTGGACAAAGGCTTCTTTCTTTGGACCTGAATTTATCTCCTTATTCCTATTCATGGGCCTTCATTTTGTTTTGATTTTTTTCAGAGACAGGGTCTTTCTCCAGCATCCAGGCTGGAATGCAGTGGTGCAATCATAGCTCACTGCAGCCGCGACCTCCCAGGCTCAAGCAATCCTCCCGCCTCAGCCTCCCAAGTAGCGGGGACTACAGGCACGTGCCACCAAGCCCGCCTCATATTTTCCATTTTTTGTATAAATGGAGTCTCG
GTACAGTACTGCAATCTCGGCTCACTGCAACCTCCATATCCGGAGTTCAAGCAATTCTCCTGCCTCAGCCTAGCGAGTAGCTGAGATGACAGGCAGGTGCCACCACGCCCAACTAATTTTTGCATTTTTAATAGAGACGGGGTTTCACTGTGTTGGCCAGACTGGTCTCAAACTCCTGATCCTGACCTCAGGTGATTCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCAGGACTGGCCAAGTTCCTAAATTTCAAAGGCAGAAGACTTTCCTGTCACAGTTGACAGTTTATTGTAACAGTTACCTGCAGGGGCTGTGGATTTGTAACCTTGAAACAATGAATGCTGGTTATATGAAACTCCTTTTATTAGACTGTTGTAAGGAAGGGTGTTTGCGCCCTTAAAGCTGTAAACTACTGTTTGCCAAGGGCAGTTGAATTTGCTCACCACCCTCAAGATAAATAACCCACTGACTTCAAAGTCACCAATTCTATTATAATTAACTATCTAGAATAAAAGAACTGTACATTTTCTTATAGTTAGAAACATTATTTGAAAGCCTGTCTCTTTGCCTGAGGTAAATGACCTATGATCATGCCACTGTACTCCAGCCTAGGCGACAGAGGAAGGTTCCGACTTTTCCTTTCTTTTTTCTTTTTCTGGGAGACAGGGTCTCGCTCTATTGCCTAGGCTGGAGTGCAGTGGCATGACCTTGGTTACTGCAGCCTTGACCTCATGGGTTCAAGTGATCCTCCCACCTCAGCTTCCCAGTAGCTAAGACTACAGGTGTGCGCCACTGCACCTGGCTAATTTTTGTAGAGATGTGATTGTGCCATGTTGCCCAGGCTGGACTTGAACTACCAAGCTCAAATGATCCACCTGCCTCAGCCTCCCATAGTGCTGGGATTACAGGCATGAGCCACCTGGCCCGGCCCAATCCCAATGCTTAAAACACACACACACACACACACACACACACACACACACGCACACACACACACACACACACTACAAAATCTTGTTCTTCGATTCTTTCTCTCATCTCTATTTCTTACAACTACCCTGAAAAATAGGTATTGGCCACACCCAATTTATACATGAGGAAATTGAGGCTCAGAGAGGTTCTGAGACCTGCCCTAAGTCACACAGTGGCTGAGTACTGAAGCTCAGTTTTGCTTGGCTCCTGAGGCTATACATTTTACATGGAGCTCTGCTGGACTTTGGTTCCCTGTGCTAAGAAATGATAGTGTACAATTTACACTTCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCCGGCAGATCACCTGAGGTCAAGAGTTCAAGACCAGCCAATATGGCAAAATCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTATGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGACTGAGGCAGGAGAGTCACTTGAACCCGGGAGGCAGAGGTTGCAGTAAGCCAAGATTGCGCTACTGCACTCCAGCCTGGACGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAATTTACACTTCCCACTGATAGTGGGAAGCAGGGGGTTTGGGGAAGCTGGGAGCCAAGCTGGGAGCCAAGGTGGGAGTGAAGTGAGGGGCAGGGGTTTGGTACCTGCAGCAGGGCCAGGGCCCAGGTGAAACGGATGCGACAGCAGCGGAGAGAAGAGCGGGAGGCAAAGACGCCAGCCTGGTACAGCATCTGGTACCTGAGGTTAGGGTTGGGGGGAGGAGAGGAGGCTCCTCCAGGGACCATCCCGCTCCCCCCGGTGCCTACTGGGCAGGGCAGCTGCATCACCACGGCGCCCTCCCAGCCCACTGCCCTCGCTCCTCTTACCAGCGGTATTGCTGAGCGTGACTCAGGGAAGTGTTCCAGAAAAAGAGGAGTTCAAACTGCAACAAATACCAGACAGGGGAGATGGACGGGGCTGTGTGGGTCCCAGCCCCAATCGCCACCTCCACACCCCTCCTAGCACCCCTCACTTACAAGTCCCTGGTTAATGAAATACTTGGCAAAGTAAACTACGACCAAGGGAACAATGTACCACAGCAGACCCTGGAAAAGGCAGAAGATATAAGCGGGGGGCCTGGAGGTGAGCAAGCCCCACAGGGACATACCCCAGCCATCATCCGAACCTTGAACACTGTCCACCTTTCCCGAAGGGAGAGGCTGGAGCTGGAGCCTGCAGGGGAACAGAGAGAGAAGGGCAGATGAAGTTTTCACACTGAAGACTCGGCAAAGAGGCACCGGTATGACAGAATTAACCAGACCACGCAACAGTGGGAACTCACTTCCATGCCACTGGATTGGACACTTAAAAATGGTTAAAATGGCTGGGCGCAGTGGCTCATGCTTGTAATCCCAGCACCTTGGGAGACTGAGGTGGGCGGATCACCTGAGGTCAGGAGTTCAAGACCACCCTGGCCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCATGTGTGGTGGCAGGTGTCTGTAGTCCCAGCTACTCGGGTGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGTAGTGAGCTGAGATTGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCACCTCAAAAAAATAAAGTAAGATAAAAAATAATAAAATGGTAAACTTCAAGTAATATACATACTTTATCATGATGAAAATAAAAGCTAACCAGGTGAGACCTCTTCACGTCTCTTTGATTTTTAATTTTTTTTATTTTTTGAGACAGAGTCTCACTCAGTTGCCCAGGCTGCAGTGCAGTGGTGCAATCTCAGCTCACTGCAGCCTCTGCCTCCTGGGTTCAAGTGATTCTCGTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCATGCACCACCACACCTGGCTAATTTTTTTATTTTTAGTAGAGACGGGGTTTTACCATGTTGGCCAGACTGGTCTCAAACTCTTGATCTCAAATGATCCATCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTATGAACCACCACGCCCGGCCAATGTCTCTTGTACAGCTCCACAGATGGCCATTGGCCCACCCTGCCCAGTCTCACTGGCCATTCTCTGGTTCTAGAACATCCCAGCTTATCCCCACCGCAGGGCCTCAGCACTTGTGATTGGAATGCCTGGCACATGGTAAGTACTCAATTAATATCCCTTCTTCTCTCCCTCCCTTCCTTCCTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTGCGACAAGGTCTTGCTCTGTTGCCCAGGCTGGACTCAGACTTCTGAGCTCAAGTGGTCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATATTACAGGCGTGAGCCACTGTGCTCGTCCTCAACAAGTATTTCTCAAATAGACAAAGGCTTTTCCCATAACCAGTACACTCACTCTCTTTCCCCTCTTAACTTTGCCTATTGCAGAGAGGAAAAGGCCAAACCCAGAGAGAAAGAAAGTGACCTCTCTGAGGGTCTGTGTCTCCTACCTGGCTTCGACTCCGGGGCCTCGGTTCTTATGAGGGGCTGCCGGGCTGCGCTCTCTGCTTCTTCTTCCCCTCCAGGGTCCTGGGCCTCAGGAGATGTGAGCAACAAGAAATAGCTAGGAGTAGGATGAAGGCAGGGTCAGAAAACCCTACTGGCTGGGAAGGTCCCCAGGGACCATCTAGGCCACTTTTCCCAGGGAACACCTCTACCTTTGAACACTTTCAAAGATGGGTAGCTCACTGCCTCTAAGGCTCCTACGCTGTGCGGGAGAGCTCCAATTGTGGACAAAGGCTTCTTTCTTTGGACCTGAATTTATCTCCTTATTCCTATTCATGGGCCTTCATTTTGTTTTGATTTTTTTCAGAGACAGGGTCTTTCTCCAGCATCCAGGCTGGAATGCAGTGGTGCAATCATAGCTCACTGCAGCCGCGACCTCCCAGGCTCAAGCAATCCTCCCGCCTCAGCCTCCCAAGTAGCGGGGACTACAGGCACGTGCCACCAAGCCCGCCTCATATTTTCCATTTTTTGTATAAATGGAGTCTCG