question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Classify the chromosome 2 variant at position 178580350 affecting gene TTN as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AGTATCTATACTTTTATTACCCAAGCATAGTGCCATTTTTTTTTTCCTCTTGGAATATGCATAGTTGTTGTCTTTTTTGGTGAACAATTTTAACTTACAAAAATAGATATTATAATTAAGAAATACTTTATTAACTATTACATTAGGATATTTTCAATAAAATTAAACATTAACCATATGTACTGAAATAAAAACACATTTCTGTATAAGCAGATAATGTTATCGATAAGCACATGTTCAACTGTTCTCAGGGAAATATTTGTGAGGAATCTTGATGTAAAAGCTGTAGGATAAGAACAAACAAAATACCTGTAATTGGA...
AGTATCTATACTTTTATTACCCAAGCATAGTGCCATTTTTTTTTTCCTCTTGGAATATGCATAGTTGTTGTCTTTTTTGGTGAACAATTTTAACTTACAAAAATAGATATTATAATTAAGAAATACTTTATTAACTATTACATTAGGATATTTTCAATAAAATTAAACATTAACCATATGTACTGAAATAAAAACACATTTCTGTATAAGCAGATAATGTTATCGATAAGCACATGTTCAACTGTTCTCAGGGAAATATTTGTGAGGAATCTTGATGTAAAAGCTGTAGGATAAGAACAAACAAAATACCTGTAATTGGA...
pathogenic
49,137
Is the genetic variant on chromosome 2, position 178580410, gene TTN, benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
ATAGTTGTTGTCTTTTTTGGTGAACAATTTTAACTTACAAAAATAGATATTATAATTAAGAAATACTTTATTAACTATTACATTAGGATATTTTCAATAAAATTAAACATTAACCATATGTACTGAAATAAAAACACATTTCTGTATAAGCAGATAATGTTATCGATAAGCACATGTTCAACTGTTCTCAGGGAAATATTTGTGAGGAATCTTGATGTAAAAGCTGTAGGATAAGAACAAACAAAATACCTGTAATTGGAGAACCACCAGTTTTCTTGGGGTCAGTCCAAGTTAGAGATACTGAATCGTGTCTGACATCC...
ATAGTTGTTGTCTTTTTTGGTGAACAATTTTAACTTACAAAAATAGATATTATAATTAAGAAATACTTTATTAACTATTACATTAGGATATTTTCAATAAAATTAAACATTAACCATATGTACTGAAATAAAAACACATTTCTGTATAAGCAGATAATGTTATCGATAAGCACATGTTCAACTGTTCTCAGGGAAATATTTGTGAGGAATCTTGATGTAAAAGCTGTAGGATAAGAACAAACAAAATACCTGTAATTGGAGAACCACCAGTTTTCTTGGGGTCAGTCCAAGTTAGAGATACTGAATCGTGTCTGACATCC...
pathogenic
49,142
Is the variant located on chromosome 2 at position 178580561, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AGATAATGTTATCGATAAGCACATGTTCAACTGTTCTCAGGGAAATATTTGTGAGGAATCTTGATGTAAAAGCTGTAGGATAAGAACAAACAAAATACCTGTAATTGGAGAACCACCAGTTTTCTTGGGGTCAGTCCAAGTTAGAGATACTGAATCGTGTCTGACATCCACAATATTGGGAGGTGGGGGAGCATCAGGCACATCTAGAAAAAAGTAGATAATGCAAGATTTATAATAAGAAGCCTCCTCAAAACCGTGTTTTGCTTTACGTCTTCTGAATTTAAGACACTTACCAAATGGATGTCTCGCAACAATTGGCT...
AGATAATGTTATCGATAAGCACATGTTCAACTGTTCTCAGGGAAATATTTGTGAGGAATCTTGATGTAAAAGCTGTAGGATAAGAACAAACAAAATACCTGTAATTGGAGAACCACCAGTTTTCTTGGGGTCAGTCCAAGTTAGAGATACTGAATCGTGTCTGACATCCACAATATTGGGAGGTGGGGGAGCATCAGGCACATCTAGAAAAAAGTAGATAATGCAAGATTTATAATAAGAAGCCTCCTCAAAACCGTGTTTTGCTTTACGTCTTCTGAATTTAAGACACTTACCAAATGGATGTCTCGCAACAATTGGCT...
pathogenic
49,149
Variant in gene TTN, located at chromosome 2 position 178582126: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TGTAGACCAGGATTTCCTCTCTGCATCACGTTTTTGTACCACATAGTTTATGATGGGGCTTCCGCCATCAATAATGGGAGGCTCCCAGGTAACATAAGCAGAGTCTTTGGATATTTCCTTAACAGTCACATTGACAGGTGGCCCAGGAGTATCTGGATAAATAGTAGGTAAATAAGAAATGAATGTGTAAAAAATACATAAGCTATTTTAAAATATATATGATTCTTTTTTGAAATAGACTTACCAAGCACTTTCACAACAATGGTATATTCCTTTTTACCACAGCTGTTCTCCAGGGTTAAGATATATTTTCCTGCATC...
TGTAGACCAGGATTTCCTCTCTGCATCACGTTTTTGTACCACATAGTTTATGATGGGGCTTCCGCCATCAATAATGGGAGGCTCCCAGGTAACATAAGCAGAGTCTTTGGATATTTCCTTAACAGTCACATTGACAGGTGGCCCAGGAGTATCTGGATAAATAGTAGGTAAATAAGAAATGAATGTGTAAAAAATACATAAGCTATTTTAAAATATATATGATTCTTTTTTGAAATAGACTTACCAAGCACTTTCACAACAATGGTATATTCCTTTTTACCACAGCTGTTCTCCAGGGTTAAGATATATTTTCCTGCATC...
pathogenic
49,188
Considering the variant on chromosome 2, location 178582216, involving gene TTN, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
benign
AACATAAGCAGAGTCTTTGGATATTTCCTTAACAGTCACATTGACAGGTGGCCCAGGAGTATCTGGATAAATAGTAGGTAAATAAGAAATGAATGTGTAAAAAATACATAAGCTATTTTAAAATATATATGATTCTTTTTTGAAATAGACTTACCAAGCACTTTCACAACAATGGTATATTCCTTTTTACCACAGCTGTTCTCCAGGGTTAAGATATATTTTCCTGCATCATATTTGTTCACATTTTCACAGCGCAAGAAAGTGTCAAAGTCAGTTGACTTTATGTCCAGTCCAATCCTGTCTCTTAGATTGACATTTGG...
AACATAAGCAGAGTCTTTGGATATTTCCTTAACAGTCACATTGACAGGTGGCCCAGGAGTATCTGGATAAATAGTAGGTAAATAAGAAATGAATGTGTAAAAAATACATAAGCTATTTTAAAATATATATGATTCTTTTTTGAAATAGACTTACCAAGCACTTTCACAACAATGGTATATTCCTTTTTACCACAGCTGTTCTCCAGGGTTAAGATATATTTTCCTGCATCATATTTGTTCACATTTTCACAGCGCAAGAAAGTGTCAAAGTCAGTTGACTTTATGTCCAGTCCAATCCTGTCTCTTAGATTGACATTTGG...
benign
49,193
Classify the chromosome 2 variant at position 178583096 affecting gene TTN as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Cardiovascular_phenotype', 'Primary_dilated_cardiomyopathy']
TAAAGGGGAAATTATCATGGAGGATAAGCAAATAGAAGAAATAAGAAGAAGGGAAATTAAGATGGAGAGCCCACCAGTCACATACTTAGGGAGATGGTGGATTGGAAAACAGAAACCCTAAGAATAGTAAATAGCTCACTACTTAGTTAAAAGGCCTCTTTATTCCTAAAATAAAATTCTTACATTCCAATAAAATTCTCTCATTTCATGTCTTTTGAAGACAGGAAATTCTTATATATATGAAAAGCTTTTCAAAACCACAAATCATGTGCATTTGATTTGCCTGTTCCACAATACCGTAAAGTACCCACCCAGCTCTC...
TAAAGGGGAAATTATCATGGAGGATAAGCAAATAGAAGAAATAAGAAGAAGGGAAATTAAGATGGAGAGCCCACCAGTCACATACTTAGGGAGATGGTGGATTGGAAAACAGAAACCCTAAGAATAGTAAATAGCTCACTACTTAGTTAAAAGGCCTCTTTATTCCTAAAATAAAATTCTTACATTCCAATAAAATTCTCTCATTTCATGTCTTTTGAAGACAGGAAATTCTTATATATATGAAAAGCTTTTCAAAACCACAAATCATGTGCATTTGATTTGCCTGTTCCACAATACCGTAAAGTACCCACCCAGCTCTC...
pathogenic
49,216
Mutation found at chromosome 2 position 178583105, gene TTN: benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G']
AATTATCATGGAGGATAAGCAAATAGAAGAAATAAGAAGAAGGGAAATTAAGATGGAGAGCCCACCAGTCACATACTTAGGGAGATGGTGGATTGGAAAACAGAAACCCTAAGAATAGTAAATAGCTCACTACTTAGTTAAAAGGCCTCTTTATTCCTAAAATAAAATTCTTACATTCCAATAAAATTCTCTCATTTCATGTCTTTTGAAGACAGGAAATTCTTATATATATGAAAAGCTTTTCAAAACCACAAATCATGTGCATTTGATTTGCCTGTTCCACAATACCGTAAAGTACCCACCCAGCTCTCCTAAAAAGT...
AATTATCATGGAGGATAAGCAAATAGAAGAAATAAGAAGAAGGGAAATTAAGATGGAGAGCCCACCAGTCACATACTTAGGGAGATGGTGGATTGGAAAACAGAAACCCTAAGAATAGTAAATAGCTCACTACTTAGTTAAAAGGCCTCTTTATTCCTAAAATAAAATTCTTACATTCCAATAAAATTCTCTCATTTCATGTCTTTTGAAGACAGGAAATTCTTATATATATGAAAAGCTTTTCAAAACCACAAATCATGTGCATTTGATTTGCCTGTTCCACAATACCGTAAAGTACCCACCCAGCTCTCCTAAAAAGT...
pathogenic
49,219
Classify the chromosome 2 variant at position 178583237 affecting gene TTN as benign or pathogenic. If pathogenic, which disease(s) is associated?
benign
CTTAGTTAAAAGGCCTCTTTATTCCTAAAATAAAATTCTTACATTCCAATAAAATTCTCTCATTTCATGTCTTTTGAAGACAGGAAATTCTTATATATATGAAAAGCTTTTCAAAACCACAAATCATGTGCATTTGATTTGCCTGTTCCACAATACCGTAAAGTACCCACCCAGCTCTCCTAAAAAGTACTCTTGGAGTTACCAGCTCTACACCTTGTTAATAAATTAATCTACCTAAGGGAGTTCTAGTCTCCCTCTTAGAATATGATTAATAGGAAAAGCCTTATGTACTCCCCCTGGTAATACTTACTTAAGATGTC...
CTTAGTTAAAAGGCCTCTTTATTCCTAAAATAAAATTCTTACATTCCAATAAAATTCTCTCATTTCATGTCTTTTGAAGACAGGAAATTCTTATATATATGAAAAGCTTTTCAAAACCACAAATCATGTGCATTTGATTTGCCTGTTCCACAATACCGTAAAGTACCCACCCAGCTCTCCTAAAAAGTACTCTTGGAGTTACCAGCTCTACACCTTGTTAATAAATTAATCTACCTAAGGGAGTTCTAGTCTCCCTCTTAGAATATGATTAATAGGAAAAGCCTTATGTACTCCCCCTGGTAATACTTACTTAAGATGTC...
benign
49,228
Variant at chromosome position 178583650, chromosome 2, gene TTN: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CAGGCCAGTAACCTCAAAGCGGGTTTTCTGTAGATTCTGTGGTAAGTTGCACCTCACCCAGTTATCGGAGTCAGCCCGTTTTACTTCAACGAGATAACCAATGATAGGGCTGCCGCCGTCATAGGCTGGCTTGCCCCAAGATAGACTCACAGAGCTGCGAGTTGTATCATATACTTTAGGGAAAGCCGGTGGGCCAGGAGGATCTGAGAATAAATAATGATAGGAAATTTTCATGAAAACTTCCTTCCTGGGTGTTTAATGCTGCTTTTAACACAGGATATGGAACTCGTTCATGAACACTTACACTGAGGGTCCCGAGC...
CAGGCCAGTAACCTCAAAGCGGGTTTTCTGTAGATTCTGTGGTAAGTTGCACCTCACCCAGTTATCGGAGTCAGCCCGTTTTACTTCAACGAGATAACCAATGATAGGGCTGCCGCCGTCATAGGCTGGCTTGCCCCAAGATAGACTCACAGAGCTGCGAGTTGTATCATATACTTTAGGGAAAGCCGGTGGGCCAGGAGGATCTGAGAATAAATAATGATAGGAAATTTTCATGAAAACTTCCTTCCTGGGTGTTTAATGCTGCTTTTAACACAGGATATGGAACTCGTTCATGAACACTTACACTGAGGGTCCCGAGC...
pathogenic
49,234
Evaluate this variant at chromosome 2, position 178583676, gene TTN: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Primary_dilated_cardiomyopathy', 'Tibial_muscular_dystrophy']
TCTGTAGATTCTGTGGTAAGTTGCACCTCACCCAGTTATCGGAGTCAGCCCGTTTTACTTCAACGAGATAACCAATGATAGGGCTGCCGCCGTCATAGGCTGGCTTGCCCCAAGATAGACTCACAGAGCTGCGAGTTGTATCATATACTTTAGGGAAAGCCGGTGGGCCAGGAGGATCTGAGAATAAATAATGATAGGAAATTTTCATGAAAACTTCCTTCCTGGGTGTTTAATGCTGCTTTTAACACAGGATATGGAACTCGTTCATGAACACTTACACTGAGGGTCCCGAGCATAAGCGGCCTTGGATGCGTCACTGG...
TCTGTAGATTCTGTGGTAAGTTGCACCTCACCCAGTTATCGGAGTCAGCCCGTTTTACTTCAACGAGATAACCAATGATAGGGCTGCCGCCGTCATAGGCTGGCTTGCCCCAAGATAGACTCACAGAGCTGCGAGTTGTATCATATACTTTAGGGAAAGCCGGTGGGCCAGGAGGATCTGAGAATAAATAATGATAGGAAATTTTCATGAAAACTTCCTTCCTGGGTGTTTAATGCTGCTTTTAACACAGGATATGGAACTCGTTCATGAACACTTACACTGAGGGTCCCGAGCATAAGCGGCCTTGGATGCGTCACTGG...
pathogenic
49,238
Does the genetic variant at chromosome 2, position 178584255, impacting gene TTN, appear benign or pathogenic? If pathogenic, name the associated disease(s).
benign
GTCTGCAGAAATTGATTGAAAAGTTAATTTCCCAGGCTAAAAGATAATTTTAAAAAATAAAATGAAAAACCACCGGGAAATGTTCCTACCATATGGGTTTTTGGCAATTGCTGGTTCAGTGAAGACTGGATCGCCTACTCCATATTTATTTTCAGCACAAATACGGAACTGATACTCATGGCCCTCTATAAGTTTCTCCACGCTGCAGCTGGTGATAGGCACAGTTGCAGAGACTTGAGCCCAGTTGGGCCTGCTTGTTTCACGTTTGTCAACAATATAGTTGGTGATTTCTGAGCCTCCATCTTCAAGAGGCGGTTCCC...
GTCTGCAGAAATTGATTGAAAAGTTAATTTCCCAGGCTAAAAGATAATTTTAAAAAATAAAATGAAAAACCACCGGGAAATGTTCCTACCATATGGGTTTTTGGCAATTGCTGGTTCAGTGAAGACTGGATCGCCTACTCCATATTTATTTTCAGCACAAATACGGAACTGATACTCATGGCCCTCTATAAGTTTCTCCACGCTGCAGCTGGTGATAGGCACAGTTGCAGAGACTTGAGCCCAGTTGGGCCTGCTTGTTTCACGTTTGTCAACAATATAGTTGGTGATTTCTGAGCCTCCATCTTCAAGAGGCGGTTCCC...
benign
49,250
Is the variant located on chromosome 2 at position 178584653, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
benign
GGAAGAAGAGTGAATATGTGGAATGGGGAATGAGTATAGAGTAGAGGTCTGGAGACCTGGGCTGCAGTCTTTCTATTGTCAATTTCCTATATGACCTAGGAGGTTAGTTAATTTTTTAGAATCTTAGTTTCTTCACTTGTAAAATTAGGTAATTGAAATATGTGATTTCTAAAGCTCTTTTTAACTCTAAAACGTGGTTCTGTCATAAGAATAATTCTGTGCATAGGAAATACACATTAGAATATGAATGTCTTCTCCCACATTATTCTGTAAATCCTATTTACATCCCATTATCCAAAGTAAAATATGGGATTCCAATG...
GGAAGAAGAGTGAATATGTGGAATGGGGAATGAGTATAGAGTAGAGGTCTGGAGACCTGGGCTGCAGTCTTTCTATTGTCAATTTCCTATATGACCTAGGAGGTTAGTTAATTTTTTAGAATCTTAGTTTCTTCACTTGTAAAATTAGGTAATTGAAATATGTGATTTCTAAAGCTCTTTTTAACTCTAAAACGTGGTTCTGTCATAAGAATAATTCTGTGCATAGGAAATACACATTAGAATATGAATGTCTTCTCCCACATTATTCTGTAAATCCTATTTACATCCCATTATCCAAAGTAAAATATGGGATTCCAATG...
benign
49,268
The mutation impacting TTN on chromosome 2 at position 178584952: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GTAAAATATGGGATTCCAATGAAGTTTATTAGTTACCTAACACTTTAAGCTTAATGGTGGCTGATTTAGAACCACTTGAATTTTCAGCAGTAATGGTATAGTCTCCTGAGTCCTTCCGGTTCACGCTGAATAGCTCCAAGGTGCACAGATTCCGCTGCATGGCCATCTTTATGCCTTCTGCTGGTTTTAGCAGTGTGCCATCTTTTTTCCAAGAAACTGTTGGCATCGGTTTACCAAAAACAGTAGCATCCAAGCAGACATTAGTTCCAGCTTTCACAGTAAGCAAAGATTTCATAGCCACACTCAGGTCTATCCTGGGA...
GTAAAATATGGGATTCCAATGAAGTTTATTAGTTACCTAACACTTTAAGCTTAATGGTGGCTGATTTAGAACCACTTGAATTTTCAGCAGTAATGGTATAGTCTCCTGAGTCCTTCCGGTTCACGCTGAATAGCTCCAAGGTGCACAGATTCCGCTGCATGGCCATCTTTATGCCTTCTGCTGGTTTTAGCAGTGTGCCATCTTTTTTCCAAGAAACTGTTGGCATCGGTTTACCAAAAACAGTAGCATCCAAGCAGACATTAGTTCCAGCTTTCACAGTAAGCAAAGATTTCATAGCCACACTCAGGTCTATCCTGGGA...
pathogenic
49,282
Considering the genetic mutation at chromosome 2, position 178584952, impacting TTN: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'likely other unspecified diseases']
GTAAAATATGGGATTCCAATGAAGTTTATTAGTTACCTAACACTTTAAGCTTAATGGTGGCTGATTTAGAACCACTTGAATTTTCAGCAGTAATGGTATAGTCTCCTGAGTCCTTCCGGTTCACGCTGAATAGCTCCAAGGTGCACAGATTCCGCTGCATGGCCATCTTTATGCCTTCTGCTGGTTTTAGCAGTGTGCCATCTTTTTTCCAAGAAACTGTTGGCATCGGTTTACCAAAAACAGTAGCATCCAAGCAGACATTAGTTCCAGCTTTCACAGTAAGCAAAGATTTCATAGCCACACTCAGGTCTATCCTGGGA...
GTAAAATATGGGATTCCAATGAAGTTTATTAGTTACCTAACACTTTAAGCTTAATGGTGGCTGATTTAGAACCACTTGAATTTTCAGCAGTAATGGTATAGTCTCCTGAGTCCTTCCGGTTCACGCTGAATAGCTCCAAGGTGCACAGATTCCGCTGCATGGCCATCTTTATGCCTTCTGCTGGTTTTAGCAGTGTGCCATCTTTTTTCCAAGAAACTGTTGGCATCGGTTTACCAAAAACAGTAGCATCCAAGCAGACATTAGTTCCAGCTTTCACAGTAAGCAAAGATTTCATAGCCACACTCAGGTCTATCCTGGGA...
pathogenic
49,283
Benign or pathogenic: chromosome 2, position 178584960, gene TTN variant? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TGGGATTCCAATGAAGTTTATTAGTTACCTAACACTTTAAGCTTAATGGTGGCTGATTTAGAACCACTTGAATTTTCAGCAGTAATGGTATAGTCTCCTGAGTCCTTCCGGTTCACGCTGAATAGCTCCAAGGTGCACAGATTCCGCTGCATGGCCATCTTTATGCCTTCTGCTGGTTTTAGCAGTGTGCCATCTTTTTTCCAAGAAACTGTTGGCATCGGTTTACCAAAAACAGTAGCATCCAAGCAGACATTAGTTCCAGCTTTCACAGTAAGCAAAGATTTCATAGCCACACTCAGGTCTATCCTGGGAGGGACTGG...
TGGGATTCCAATGAAGTTTATTAGTTACCTAACACTTTAAGCTTAATGGTGGCTGATTTAGAACCACTTGAATTTTCAGCAGTAATGGTATAGTCTCCTGAGTCCTTCCGGTTCACGCTGAATAGCTCCAAGGTGCACAGATTCCGCTGCATGGCCATCTTTATGCCTTCTGCTGGTTTTAGCAGTGTGCCATCTTTTTTCCAAGAAACTGTTGGCATCGGTTTACCAAAAACAGTAGCATCCAAGCAGACATTAGTTCCAGCTTTCACAGTAAGCAAAGATTTCATAGCCACACTCAGGTCTATCCTGGGAGGGACTGG...
pathogenic
49,284
Gene TTN variant at chromosome 2, position 178585348—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AAATTCATATGCTGCTTCTTTCAAGAATGGAATTTTAGTGTTATTTCATTTTGTTTATTTTTAATAGACAAATAATAACTGCACTATTGAATAACTATTGAAATTATATAGTTGCCACAGTTGTGTATCTTGCTTTTTAATTTAGCATGTTATTATGATTCTCCATAATCATAATGTTTGTGTCTATATACAAAACATCATTTTAATTTTCCTTTTTTCCTTAGGTGTATATTTAGTTTTTTATTAGGAAAAATGACCATCATGAATGCTGTTACATCTTTGCCTATAATACTCAGCAGAATCTTACCATTTTCTGCGAG...
AAATTCATATGCTGCTTCTTTCAAGAATGGAATTTTAGTGTTATTTCATTTTGTTTATTTTTAATAGACAAATAATAACTGCACTATTGAATAACTATTGAAATTATATAGTTGCCACAGTTGTGTATCTTGCTTTTTAATTTAGCATGTTATTATGATTCTCCATAATCATAATGTTTGTGTCTATATACAAAACATCATTTTAATTTTCCTTTTTTCCTTAGGTGTATATTTAGTTTTTTATTAGGAAAAATGACCATCATGAATGCTGTTACATCTTTGCCTATAATACTCAGCAGAATCTTACCATTTTCTGCGAG...
pathogenic
49,297
A mutation at chromosome position 178586613 on chromosome 2 in gene TTN: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTCACTAGGAACACCTGGAGATGAAGACAAGGAAGATGTCAGTTTCTACATTAAGTAACAAACTAGAAAGAAAACAACTTTTTTTCTCCTTCACAAAAACATACCAAATGGGAACTGCGCAACCATCTTTGGAGATGTGAGAGGCTCTGAAATGCCAAATCGGTTTTCAGCACGGACCCGGAAGATGTACTCCTGGCCTGGGATCAGCTTTCCAACCCTGCAGGAAGTTTTTGTGACTGAAGCTAGAGCCGTGACCCAGTCACCTCGGCTTACATCACACTTCTCCACTATATAATTGGTGATGTTACTGCCTCCGTCCT...
TTCACTAGGAACACCTGGAGATGAAGACAAGGAAGATGTCAGTTTCTACATTAAGTAACAAACTAGAAAGAAAACAACTTTTTTTCTCCTTCACAAAAACATACCAAATGGGAACTGCGCAACCATCTTTGGAGATGTGAGAGGCTCTGAAATGCCAAATCGGTTTTCAGCACGGACCCGGAAGATGTACTCCTGGCCTGGGATCAGCTTTCCAACCCTGCAGGAAGTTTTTGTGACTGAAGCTAGAGCCGTGACCCAGTCACCTCGGCTTACATCACACTTCTCCACTATATAATTGGTGATGTTACTGCCTCCGTCCT...
pathogenic
49,302
A genetic alteration at chromosome 2, position 178586647, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GATGTCAGTTTCTACATTAAGTAACAAACTAGAAAGAAAACAACTTTTTTTCTCCTTCACAAAAACATACCAAATGGGAACTGCGCAACCATCTTTGGAGATGTGAGAGGCTCTGAAATGCCAAATCGGTTTTCAGCACGGACCCGGAAGATGTACTCCTGGCCTGGGATCAGCTTTCCAACCCTGCAGGAAGTTTTTGTGACTGAAGCTAGAGCCGTGACCCAGTCACCTCGGCTTACATCACACTTCTCCACTATATAATTGGTGATGTTACTGCCTCCGTCCTCCAGAGGGATGTGCCATGACAGGGAGCAAGCATC...
GATGTCAGTTTCTACATTAAGTAACAAACTAGAAAGAAAACAACTTTTTTTCTCCTTCACAAAAACATACCAAATGGGAACTGCGCAACCATCTTTGGAGATGTGAGAGGCTCTGAAATGCCAAATCGGTTTTCAGCACGGACCCGGAAGATGTACTCCTGGCCTGGGATCAGCTTTCCAACCCTGCAGGAAGTTTTTGTGACTGAAGCTAGAGCCGTGACCCAGTCACCTCGGCTTACATCACACTTCTCCACTATATAATTGGTGATGTTACTGCCTCCGTCCTCCAGAGGGATGTGCCATGACAGGGAGCAAGCATC...
pathogenic
49,303
Determine if the mutation at chromosome 2, position 178586802 in gene TTN is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G']
CTCCTGGCCTGGGATCAGCTTTCCAACCCTGCAGGAAGTTTTTGTGACTGAAGCTAGAGCCGTGACCCAGTCACCTCGGCTTACATCACACTTCTCCACTATATAATTGGTGATGTTACTGCCTCCGTCCTCCAGAGGGATGTGCCATGACAGGGAGCAAGCATCAGCGTCTATATCAGAAATGTCAAATGGAGGCTGAGGGGGGCCGGGGGCATCTACATGAACCAAGAGGAAAGAAATGTAAGAACAAGGATTTGATACGTAAAAATATTTCTGAGCTTCATATTTAGATGGCCATTTGTCTAATACTTAACTTACCC...
CTCCTGGCCTGGGATCAGCTTTCCAACCCTGCAGGAAGTTTTTGTGACTGAAGCTAGAGCCGTGACCCAGTCACCTCGGCTTACATCACACTTCTCCACTATATAATTGGTGATGTTACTGCCTCCGTCCTCCAGAGGGATGTGCCATGACAGGGAGCAAGCATCAGCGTCTATATCAGAAATGTCAAATGGAGGCTGAGGGGGGCCGGGGGCATCTACATGAACCAAGAGGAAAGAAATGTAAGAACAAGGATTTGATACGTAAAAATATTTCTGAGCTTCATATTTAGATGGCCATTTGTCTAATACTTAACTTACCC...
pathogenic
49,315
Variant chromosome 2, position 178587506, gene TTN: benign or pathogenic? Disease(s)?
benign
ATATACTTTAAGTTCTGGGATACATATGCAGAATGTGCAGGCTTGTTACATAGGTATACATGTGCCATGGTGATTTGCTGCACCCATCAACACATCGTCTACATTAGGTATTCTCCTAATGCTATCCTTCCCCTAGCCTCCCAACCCCTGACAGGCCCCAGTGTGTGATGCTCCCCTCCCTGTGTCCATGTGTTTTCATTGTTCAGCTCCCACTTATGAGTGAGAACATGTGGTGTTTGGTTTTCTGTTCTTGTGTTTGCTGAGAATGATGGTTTCCAGCTTCATCCATGTCCCTGCAAAGGACATGAACTCATCCTTTT...
ATATACTTTAAGTTCTGGGATACATATGCAGAATGTGCAGGCTTGTTACATAGGTATACATGTGCCATGGTGATTTGCTGCACCCATCAACACATCGTCTACATTAGGTATTCTCCTAATGCTATCCTTCCCCTAGCCTCCCAACCCCTGACAGGCCCCAGTGTGTGATGCTCCCCTCCCTGTGTCCATGTGTTTTCATTGTTCAGCTCCCACTTATGAGTGAGAACATGTGGTGTTTGGTTTTCTGTTCTTGTGTTTGCTGAGAATGATGGTTTCCAGCTTCATCCATGTCCCTGCAAAGGACATGAACTCATCCTTTT...
benign
49,336
Considering the genetic mutation at chromosome 2, position 178587587, impacting TTN: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ACCCATCAACACATCGTCTACATTAGGTATTCTCCTAATGCTATCCTTCCCCTAGCCTCCCAACCCCTGACAGGCCCCAGTGTGTGATGCTCCCCTCCCTGTGTCCATGTGTTTTCATTGTTCAGCTCCCACTTATGAGTGAGAACATGTGGTGTTTGGTTTTCTGTTCTTGTGTTTGCTGAGAATGATGGTTTCCAGCTTCATCCATGTCCCTGCAAAGGACATGAACTCATCCTTTTTTATGGCTGCGTAGTATCCTGTGGTGTAAATGTGGTGCCACATTTTCTTTATCCAGTCTGTCATTGATGGGCATTTGGGTT...
ACCCATCAACACATCGTCTACATTAGGTATTCTCCTAATGCTATCCTTCCCCTAGCCTCCCAACCCCTGACAGGCCCCAGTGTGTGATGCTCCCCTCCCTGTGTCCATGTGTTTTCATTGTTCAGCTCCCACTTATGAGTGAGAACATGTGGTGTTTGGTTTTCTGTTCTTGTGTTTGCTGAGAATGATGGTTTCCAGCTTCATCCATGTCCCTGCAAAGGACATGAACTCATCCTTTTTTATGGCTGCGTAGTATCCTGTGGTGTAAATGTGGTGCCACATTTTCTTTATCCAGTCTGTCATTGATGGGCATTTGGGTT...
pathogenic
49,338
Located at chromosome 2 position 178587693, the variant affecting gene TTN—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Cardiovascular_phenotype']
ATGTGTTTTCATTGTTCAGCTCCCACTTATGAGTGAGAACATGTGGTGTTTGGTTTTCTGTTCTTGTGTTTGCTGAGAATGATGGTTTCCAGCTTCATCCATGTCCCTGCAAAGGACATGAACTCATCCTTTTTTATGGCTGCGTAGTATCCTGTGGTGTAAATGTGGTGCCACATTTTCTTTATCCAGTCTGTCATTGATGGGCATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCCACAATAAACATACATGTGCATGTGTCTTTATAGTAGAATGATTTATAATCCTTTGGGTATATACCCAGTAATGA...
ATGTGTTTTCATTGTTCAGCTCCCACTTATGAGTGAGAACATGTGGTGTTTGGTTTTCTGTTCTTGTGTTTGCTGAGAATGATGGTTTCCAGCTTCATCCATGTCCCTGCAAAGGACATGAACTCATCCTTTTTTATGGCTGCGTAGTATCCTGTGGTGTAAATGTGGTGCCACATTTTCTTTATCCAGTCTGTCATTGATGGGCATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCCACAATAAACATACATGTGCATGTGTCTTTATAGTAGAATGATTTATAATCCTTTGGGTATATACCCAGTAATGA...
pathogenic
49,342
Is the genetic variant on chromosome 2, position 178587781, gene TTN, benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CCAGCTTCATCCATGTCCCTGCAAAGGACATGAACTCATCCTTTTTTATGGCTGCGTAGTATCCTGTGGTGTAAATGTGGTGCCACATTTTCTTTATCCAGTCTGTCATTGATGGGCATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCCACAATAAACATACATGTGCATGTGTCTTTATAGTAGAATGATTTATAATCCTTTGGGTATATACCCAGTAATGAGATTGCTGGGTCAAATGGTATTTCTGGTTCTAGATCCTTGAGGAATCGCCACACTGTCTTCCATAATGGTTGAACTAATTTACACTCC...
CCAGCTTCATCCATGTCCCTGCAAAGGACATGAACTCATCCTTTTTTATGGCTGCGTAGTATCCTGTGGTGTAAATGTGGTGCCACATTTTCTTTATCCAGTCTGTCATTGATGGGCATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCCACAATAAACATACATGTGCATGTGTCTTTATAGTAGAATGATTTATAATCCTTTGGGTATATACCCAGTAATGAGATTGCTGGGTCAAATGGTATTTCTGGTTCTAGATCCTTGAGGAATCGCCACACTGTCTTCCATAATGGTTGAACTAATTTACACTCC...
pathogenic
49,347
Clinical significance of chromosome 2, position 178587902, gene TTN: benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCCACAATAAACATACATGTGCATGTGTCTTTATAGTAGAATGATTTATAATCCTTTGGGTATATACCCAGTAATGAGATTGCTGGGTCAAATGGTATTTCTGGTTCTAGATCCTTGAGGAATCGCCACACTGTCTTCCATAATGGTTGAACTAATTTACACTCCCACCAACAGTGTAAAAGCTTTCCTATTTCTCCACATCCTCTCTAGCACCTGTTGTTTCCTGACTTTTTAGTGATCACCATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTT...
GGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCCACAATAAACATACATGTGCATGTGTCTTTATAGTAGAATGATTTATAATCCTTTGGGTATATACCCAGTAATGAGATTGCTGGGTCAAATGGTATTTCTGGTTCTAGATCCTTGAGGAATCGCCACACTGTCTTCCATAATGGTTGAACTAATTTACACTCCCACCAACAGTGTAAAAGCTTTCCTATTTCTCCACATCCTCTCTAGCACCTGTTGTTTCCTGACTTTTTAGTGATCACCATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTT...
pathogenic
49,349
Chromosome 2, position 178588172, gene TTN: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GATCACCATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCTAGTGACCAGTGGTGATGAGCTTTTCTTCATATGTTTGTTGTACAGCCAATATTTTTAAAAACACAGAATAGGGTAGAAAACATAAGAATGCACATGATAATAAATGGGTATTGTTTCAGGAAATGTTTTTTAGTTATATATGTGTTTGTATAAGTTTATTTACTGTGTGTTTTTGGCCCACTCATGTGTTTGAAAGCCACTGTTCTCTACTGTTTTTCAAGAATTTCTAGAGCTAGATTCCTCAGGGAGAAATGTCTACA...
GATCACCATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCTAGTGACCAGTGGTGATGAGCTTTTCTTCATATGTTTGTTGTACAGCCAATATTTTTAAAAACACAGAATAGGGTAGAAAACATAAGAATGCACATGATAATAAATGGGTATTGTTTCAGGAAATGTTTTTTAGTTATATATGTGTTTGTATAAGTTTATTTACTGTGTGTTTTTGGCCCACTCATGTGTTTGAAAGCCACTGTTCTCTACTGTTTTTCAAGAATTTCTAGAGCTAGATTCCTCAGGGAGAAATGTCTACA...
pathogenic
49,361
Clinically, how would you classify the variant at chromosome 2, position 178588674, gene TTN: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Tibial_muscular_dystrophy']
GCTCAGATCTTTTACCACTGAGTACTCTGTCCAGCGATCTGCAGGCTGCTCTTCTTCTCTGTAACTAGTGATGTAGCCATCGATTTTAGCACCTCCATCACGTAGGGGAGGTAACCAGGCTAAGGTGGCACTGTTCTTGGTCATTTCAGTCACTTCTAATTTCCTTGGGGGATCCGGCTCACCTAGAAGAAAAACATAATTTAGAAGATTACCTAGGTAACCTAATCAAATCCCCTTTGTTAATGTACATAAGAGTTTTAGTATGGATTTGCTCCAATGTACATAGAACCTGTAGTTCAGTACATTAAAAGCAAAACATA...
GCTCAGATCTTTTACCACTGAGTACTCTGTCCAGCGATCTGCAGGCTGCTCTTCTTCTCTGTAACTAGTGATGTAGCCATCGATTTTAGCACCTCCATCACGTAGGGGAGGTAACCAGGCTAAGGTGGCACTGTTCTTGGTCATTTCAGTCACTTCTAATTTCCTTGGGGGATCCGGCTCACCTAGAAGAAAAACATAATTTAGAAGATTACCTAGGTAACCTAATCAAATCCCCTTTGTTAATGTACATAAGAGTTTTAGTATGGATTTGCTCCAATGTACATAGAACCTGTAGTTCAGTACATTAAAAGCAAAACATA...
pathogenic
49,373
The chromosome 2, position 178588758 genetic variant in gene TTN: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTTAGCACCTCCATCACGTAGGGGAGGTAACCAGGCTAAGGTGGCACTGTTCTTGGTCATTTCAGTCACTTCTAATTTCCTTGGGGGATCCGGCTCACCTAGAAGAAAAACATAATTTAGAAGATTACCTAGGTAACCTAATCAAATCCCCTTTGTTAATGTACATAAGAGTTTTAGTATGGATTTGCTCCAATGTACATAGAACCTGTAGTTCAGTACATTAAAAGCAAAACATATAAGATGAGACAGATCAAAAAAGTGTTTCATGAGTGAGATAGATATTTATTACACTATTTCGGTCTCTACAAATGAAATCTCTT...
TTTAGCACCTCCATCACGTAGGGGAGGTAACCAGGCTAAGGTGGCACTGTTCTTGGTCATTTCAGTCACTTCTAATTTCCTTGGGGGATCCGGCTCACCTAGAAGAAAAACATAATTTAGAAGATTACCTAGGTAACCTAATCAAATCCCCTTTGTTAATGTACATAAGAGTTTTAGTATGGATTTGCTCCAATGTACATAGAACCTGTAGTTCAGTACATTAAAAGCAAAACATATAAGATGAGACAGATCAAAAAAGTGTTTCATGAGTGAGATAGATATTTATTACACTATTTCGGTCTCTACAAATGAAATCTCTT...
pathogenic
49,380
Mutation at chromosome 2, position 178588815, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
CATTTCAGTCACTTCTAATTTCCTTGGGGGATCCGGCTCACCTAGAAGAAAAACATAATTTAGAAGATTACCTAGGTAACCTAATCAAATCCCCTTTGTTAATGTACATAAGAGTTTTAGTATGGATTTGCTCCAATGTACATAGAACCTGTAGTTCAGTACATTAAAAGCAAAACATATAAGATGAGACAGATCAAAAAAGTGTTTCATGAGTGAGATAGATATTTATTACACTATTTCGGTCTCTACAAATGAAATCTCTTTCAGAAGTGGATTAAAATGGTATTAGTATCTTGACCTTGCTAAAATAGGAGACTGGG...
CATTTCAGTCACTTCTAATTTCCTTGGGGGATCCGGCTCACCTAGAAGAAAAACATAATTTAGAAGATTACCTAGGTAACCTAATCAAATCCCCTTTGTTAATGTACATAAGAGTTTTAGTATGGATTTGCTCCAATGTACATAGAACCTGTAGTTCAGTACATTAAAAGCAAAACATATAAGATGAGACAGATCAAAAAAGTGTTTCATGAGTGAGATAGATATTTATTACACTATTTCGGTCTCTACAAATGAAATCTCTTTCAGAAGTGGATTAAAATGGTATTAGTATCTTGACCTTGCTAAAATAGGAGACTGGG...
pathogenic
49,384
Mutation at chromosome 2, position 178589127, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AGACTGGGGTTAAAAGGAGGAAGAAAGCATAATACTTACTTAGAGGATCTGATGCAAGCACTGGTTTTGGGACATCTGTTGGGACGCCAGGGCCATATTCGTTGACAGCAGTTACTCTGAAGTAATACTCATTCCCAGGGACAAGATTGGTTACATGGAAGCTTGTTTTCTTAACTTCTGGGGTAACGGTCGACCATGTCTTTCTGTCTGCCTCACGTTTCTCCACGATATAATGTGTCACTTGGCTCCCACCGTCGTTTTCAGGAGGGGCCCAGGACACATGGCATGATGTTTTAGTGACATCTGAAACTTTTAAATCA...
AGACTGGGGTTAAAAGGAGGAAGAAAGCATAATACTTACTTAGAGGATCTGATGCAAGCACTGGTTTTGGGACATCTGTTGGGACGCCAGGGCCATATTCGTTGACAGCAGTTACTCTGAAGTAATACTCATTCCCAGGGACAAGATTGGTTACATGGAAGCTTGTTTTCTTAACTTCTGGGGTAACGGTCGACCATGTCTTTCTGTCTGCCTCACGTTTCTCCACGATATAATGTGTCACTTGGCTCCCACCGTCGTTTTCAGGAGGGGCCCAGGACACATGGCATGATGTTTTAGTGACATCTGAAACTTTTAAATCA...
pathogenic
49,392
Chromosome 2, position 178589384, gene TTN: Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Tibial_muscular_dystrophy']
TTTTCAGGAGGGGCCCAGGACACATGGCATGATGTTTTAGTGACATCTGAAACTTTTAAATCAGACACAGGCCCAGGAGTGTCTGTAAAGAATCATAAAATCAGATATACATGTCTCCTCAGCATCCCTATTAACAAATTCATTTTTGAAGTGGGAGGGAGAAGCATTTTAGTAACCCACCTAATACTCTGACATTTACGAATACAGCCTTTTCTCCTGCTGGGTTCACAAGTGTTAAGGAATATTTTCCTGAGTCATCACGGGTAGAATTGGGGATGACAAGGAAGGCCATAGTGTCAACCAGATCAACTTGTCCTTTT...
TTTTCAGGAGGGGCCCAGGACACATGGCATGATGTTTTAGTGACATCTGAAACTTTTAAATCAGACACAGGCCCAGGAGTGTCTGTAAAGAATCATAAAATCAGATATACATGTCTCCTCAGCATCCCTATTAACAAATTCATTTTTGAAGTGGGAGGGAGAAGCATTTTAGTAACCCACCTAATACTCTGACATTTACGAATACAGCCTTTTCTCCTGCTGGGTTCACAAGTGTTAAGGAATATTTTCCTGAGTCATCACGGGTAGAATTGGGGATGACAAGGAAGGCCATAGTGTCAACCAGATCAACTTGTCCTTTT...
pathogenic
49,398
The mutation in gene TTN at chromosome 2, position 178589473—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GAATCATAAAATCAGATATACATGTCTCCTCAGCATCCCTATTAACAAATTCATTTTTGAAGTGGGAGGGAGAAGCATTTTAGTAACCCACCTAATACTCTGACATTTACGAATACAGCCTTTTCTCCTGCTGGGTTCACAAGTGTTAAGGAATATTTTCCTGAGTCATCACGGGTAGAATTGGGGATGACAAGGAAGGCCATAGTGTCAACCAGATCAACTTGTCCTTTTCTGACCACATTATCAATGCCAACTTTTCGCCAAGTGACTTTAGGGGCTGGTCGTCCTCTCACTATAGCAAAGAGACGAATAGGGCATCC...
GAATCATAAAATCAGATATACATGTCTCCTCAGCATCCCTATTAACAAATTCATTTTTGAAGTGGGAGGGAGAAGCATTTTAGTAACCCACCTAATACTCTGACATTTACGAATACAGCCTTTTCTCCTGCTGGGTTCACAAGTGTTAAGGAATATTTTCCTGAGTCATCACGGGTAGAATTGGGGATGACAAGGAAGGCCATAGTGTCAACCAGATCAACTTGTCCTTTTCTGACCACATTATCAATGCCAACTTTTCGCCAAGTGACTTTAGGGGCTGGTCGTCCTCTCACTATAGCAAAGAGACGAATAGGGCATCC...
pathogenic
49,403
Variant at chromosome position 178589589, chromosome 2, gene TTN: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AGCCTTTTCTCCTGCTGGGTTCACAAGTGTTAAGGAATATTTTCCTGAGTCATCACGGGTAGAATTGGGGATGACAAGGAAGGCCATAGTGTCAACCAGATCAACTTGTCCTTTTCTGACCACATTATCAATGCCAACTTTTCGCCAAGTGACTTTAGGGGCTGGTCGTCCTCTCACTATAGCAAAGAGACGAATAGGGCATCCTGCTCTCACTATGACCAGTTTCCTCATGCTGGCATCCAAATCAATCTCCGGAGGTTCTGCAAATGACATTAAGGTCATTAATTGATTTTTCAGAATGTGGGGAAATCATAAGAAAT...
AGCCTTTTCTCCTGCTGGGTTCACAAGTGTTAAGGAATATTTTCCTGAGTCATCACGGGTAGAATTGGGGATGACAAGGAAGGCCATAGTGTCAACCAGATCAACTTGTCCTTTTCTGACCACATTATCAATGCCAACTTTTCGCCAAGTGACTTTAGGGGCTGGTCGTCCTCTCACTATAGCAAAGAGACGAATAGGGCATCCTGCTCTCACTATGACCAGTTTCCTCATGCTGGCATCCAAATCAATCTCCGGAGGTTCTGCAAATGACATTAAGGTCATTAATTGATTTTTCAGAATGTGGGGAAATCATAAGAAAT...
pathogenic
49,408
Chromosome 2, position 178589595, gene TTN: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Muscular_dystrophy']
TTCTCCTGCTGGGTTCACAAGTGTTAAGGAATATTTTCCTGAGTCATCACGGGTAGAATTGGGGATGACAAGGAAGGCCATAGTGTCAACCAGATCAACTTGTCCTTTTCTGACCACATTATCAATGCCAACTTTTCGCCAAGTGACTTTAGGGGCTGGTCGTCCTCTCACTATAGCAAAGAGACGAATAGGGCATCCTGCTCTCACTATGACCAGTTTCCTCATGCTGGCATCCAAATCAATCTCCGGAGGTTCTGCAAATGACATTAAGGTCATTAATTGATTTTTCAGAATGTGGGGAAATCATAAGAAATTAAGTG...
TTCTCCTGCTGGGTTCACAAGTGTTAAGGAATATTTTCCTGAGTCATCACGGGTAGAATTGGGGATGACAAGGAAGGCCATAGTGTCAACCAGATCAACTTGTCCTTTTCTGACCACATTATCAATGCCAACTTTTCGCCAAGTGACTTTAGGGGCTGGTCGTCCTCTCACTATAGCAAAGAGACGAATAGGGCATCCTGCTCTCACTATGACCAGTTTCCTCATGCTGGCATCCAAATCAATCTCCGGAGGTTCTGCAAATGACATTAAGGTCATTAATTGATTTTTCAGAATGTGGGGAAATCATAAGAAATTAAGTG...
pathogenic
49,409
Determine whether the variant at chromosome 2, position 178589747, in gene TTN is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
GGGCTGGTCGTCCTCTCACTATAGCAAAGAGACGAATAGGGCATCCTGCTCTCACTATGACCAGTTTCCTCATGCTGGCATCCAAATCAATCTCCGGAGGTTCTGCAAATGACATTAAGGTCATTAATTGATTTTTCAGAATGTGGGGAAATCATAAGAAATTAAGTGTGAATGAATCACATGCTAAGGGAAGGACTTACCTAGTATTTCTTTAGGTTTGATAGCTTCCTTTAGCTCTGCAGGGCGCCCAATACCAACTTGGTTTTGGGCACACACCCTGAACTCATATTCCTGGTTTTCATCCAAGCTGGTAACAGTGA...
GGGCTGGTCGTCCTCTCACTATAGCAAAGAGACGAATAGGGCATCCTGCTCTCACTATGACCAGTTTCCTCATGCTGGCATCCAAATCAATCTCCGGAGGTTCTGCAAATGACATTAAGGTCATTAATTGATTTTTCAGAATGTGGGGAAATCATAAGAAATTAAGTGTGAATGAATCACATGCTAAGGGAAGGACTTACCTAGTATTTCTTTAGGTTTGATAGCTTCCTTTAGCTCTGCAGGGCGCCCAATACCAACTTGGTTTTGGGCACACACCCTGAACTCATATTCCTGGTTTTCATCCAAGCTGGTAACAGTGA...
pathogenic
49,412
Evaluate the clinical significance of the mutation at chromosome 2, position 178589894 in gene TTN: benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GAAATCATAAGAAATTAAGTGTGAATGAATCACATGCTAAGGGAAGGACTTACCTAGTATTTCTTTAGGTTTGATAGCTTCCTTTAGCTCTGCAGGGCGCCCAATACCAACTTGGTTTTGGGCACACACCCTGAACTCATATTCCTGGTTTTCATCCAAGCTGGTAACAGTGAATTCCTTGCGTACAAGCTGTGCTGCAGCATTACACCGTTTCCAGCCTTCATCAGGAGACGCATCTGCTATTTTTGGTCTCATTTCCACAACATATCCAATGATCGGTGCACCACCATCATAGACTGGTTTTCCCCACCCAAGAGTTA...
GAAATCATAAGAAATTAAGTGTGAATGAATCACATGCTAAGGGAAGGACTTACCTAGTATTTCTTTAGGTTTGATAGCTTCCTTTAGCTCTGCAGGGCGCCCAATACCAACTTGGTTTTGGGCACACACCCTGAACTCATATTCCTGGTTTTCATCCAAGCTGGTAACAGTGAATTCCTTGCGTACAAGCTGTGCTGCAGCATTACACCGTTTCCAGCCTTCATCAGGAGACGCATCTGCTATTTTTGGTCTCATTTCCACAACATATCCAATGATCGGTGCACCACCATCATAGACTGGTTTTCCCCACCCAAGAGTTA...
pathogenic
49,417
Clinical impact (benign or pathogenic) of the variant at chromosome 2, location 178590110, gene TTN: what disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_familial_dilated_cardiomyopathy']
GCCTTCATCAGGAGACGCATCTGCTATTTTTGGTCTCATTTCCACAACATATCCAATGATCGGTGCACCACCATCATAGACTGGTTTTCCCCACCCAAGAGTTATGGAATGTTTGGTTGTATCAACCACTCTGAAATTGGTTGGTGGACCAGGTGGCTCTGAAAGTAAAATATACATATAGTTAACTACTACTAGTGATACTTCAATGTGTAATTTTATATAGCCTATTCTCAGTTAATCAAATATAGGTCATCCAATTTTTCAATTAGTGTCCTCTTTATTTTCCTTCATAAAAATGAGAATCTACTATTGTTTGTACC...
GCCTTCATCAGGAGACGCATCTGCTATTTTTGGTCTCATTTCCACAACATATCCAATGATCGGTGCACCACCATCATAGACTGGTTTTCCCCACCCAAGAGTTATGGAATGTTTGGTTGTATCAACCACTCTGAAATTGGTTGGTGGACCAGGTGGCTCTGAAAGTAAAATATACATATAGTTAACTACTACTAGTGATACTTCAATGTGTAATTTTATATAGCCTATTCTCAGTTAATCAAATATAGGTCATCCAATTTTTCAATTAGTGTCCTCTTTATTTTCCTTCATAAAAATGAGAATCTACTATTGTTTGTACC...
pathogenic
49,428
Mutation found at chromosome 2 position 178590241, gene TTN: benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TGAAATTGGTTGGTGGACCAGGTGGCTCTGAAAGTAAAATATACATATAGTTAACTACTACTAGTGATACTTCAATGTGTAATTTTATATAGCCTATTCTCAGTTAATCAAATATAGGTCATCCAATTTTTCAATTAGTGTCCTCTTTATTTTCCTTCATAAAAATGAGAATCTACTATTGTTTGTACCTTTTAGGTATTTTGGTAAAAGGTCTATTTGGAAAAATATTTGCTAAATACAGTTTGGATGTTACAGATTTAGATGTTACATTAACTTATTTATCGAATACTTCTGTGCTTGAGATTAAGAGTTGCTGTAAT...
TGAAATTGGTTGGTGGACCAGGTGGCTCTGAAAGTAAAATATACATATAGTTAACTACTACTAGTGATACTTCAATGTGTAATTTTATATAGCCTATTCTCAGTTAATCAAATATAGGTCATCCAATTTTTCAATTAGTGTCCTCTTTATTTTCCTTCATAAAAATGAGAATCTACTATTGTTTGTACCTTTTAGGTATTTTGGTAAAAGGTCTATTTGGAAAAATATTTGCTAAATACAGTTTGGATGTTACAGATTTAGATGTTACATTAACTTATTTATCGAATACTTCTGTGCTTGAGATTAAGAGTTGCTGTAAT...
pathogenic
49,433
Evaluate if the mutation on chromosome 2 at position 178590329 in TTN is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ATAGCCTATTCTCAGTTAATCAAATATAGGTCATCCAATTTTTCAATTAGTGTCCTCTTTATTTTCCTTCATAAAAATGAGAATCTACTATTGTTTGTACCTTTTAGGTATTTTGGTAAAAGGTCTATTTGGAAAAATATTTGCTAAATACAGTTTGGATGTTACAGATTTAGATGTTACATTAACTTATTTATCGAATACTTCTGTGCTTGAGATTAAGAGTTGCTGTAATATCAGAAAAAACAAGGACATCCTACCTATGGGGTCTTTTGCCACCACCGGTCTTGAAGGCAAGCTTGGTTCTCCAATTCCAATTTCAT...
ATAGCCTATTCTCAGTTAATCAAATATAGGTCATCCAATTTTTCAATTAGTGTCCTCTTTATTTTCCTTCATAAAAATGAGAATCTACTATTGTTTGTACCTTTTAGGTATTTTGGTAAAAGGTCTATTTGGAAAAATATTTGCTAAATACAGTTTGGATGTTACAGATTTAGATGTTACATTAACTTATTTATCGAATACTTCTGTGCTTGAGATTAAGAGTTGCTGTAATATCAGAAAAAACAAGGACATCCTACCTATGGGGTCTTTTGCCACCACCGGTCTTGAAGGCAAGCTTGGTTCTCCAATTCCAATTTCAT...
pathogenic
49,437
Is the variant located on chromosome 2 at position 178590730, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_familial_dilated_cardiomyopathy']
TGTTGACAGGGACCCATCGTGTTGAATGCTTTTCCTTTTTCTCCAAAAAGTATCCAGTTATAGACTTTCCACCATCATATTCAGGTGGATTCCAAACCACAGTCATCTCTTCTTTGCTTACTTTAGTGACTTCTGGGGGATCAGGGCGACCAGGTTTATCATACTTGGTTTTGGCTATGACTGGTTTACTTTCTGTTGGAGGCCCTGTGCCTATTTTATTTTCTGCACGGACTCTGAAAATATATTCATTTCCTTCTATGAGACGTGTTACTGTAGTACCAGGTGTCAAGACAGTAGCAGAATAGGTAGACCAAACCATT...
TGTTGACAGGGACCCATCGTGTTGAATGCTTTTCCTTTTTCTCCAAAAAGTATCCAGTTATAGACTTTCCACCATCATATTCAGGTGGATTCCAAACCACAGTCATCTCTTCTTTGCTTACTTTAGTGACTTCTGGGGGATCAGGGCGACCAGGTTTATCATACTTGGTTTTGGCTATGACTGGTTTACTTTCTGTTGGAGGCCCTGTGCCTATTTTATTTTCTGCACGGACTCTGAAAATATATTCATTTCCTTCTATGAGACGTGTTACTGTAGTACCAGGTGTCAAGACAGTAGCAGAATAGGTAGACCAAACCATT...
pathogenic
49,451
Evaluate this variant at chromosome 2, position 178590822, gene TTN: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Cardiovascular_phenotype']
CAAACCACAGTCATCTCTTCTTTGCTTACTTTAGTGACTTCTGGGGGATCAGGGCGACCAGGTTTATCATACTTGGTTTTGGCTATGACTGGTTTACTTTCTGTTGGAGGCCCTGTGCCTATTTTATTTTCTGCACGGACTCTGAAAATATATTCATTTCCTTCTATGAGACGTGTTACTGTAGTACCAGGTGTCAAGACAGTAGCAGAATAGGTAGACCAAACCATTCGCTTTGTCTCACATTTTTCTAGAATATAATTTTGGATTTCACAGCCACCATCATCTTCTGGTGGATCCCAGCAAACAGTACACCTATCACT...
CAAACCACAGTCATCTCTTCTTTGCTTACTTTAGTGACTTCTGGGGGATCAGGGCGACCAGGTTTATCATACTTGGTTTTGGCTATGACTGGTTTACTTTCTGTTGGAGGCCCTGTGCCTATTTTATTTTCTGCACGGACTCTGAAAATATATTCATTTCCTTCTATGAGACGTGTTACTGTAGTACCAGGTGTCAAGACAGTAGCAGAATAGGTAGACCAAACCATTCGCTTTGTCTCACATTTTTCTAGAATATAATTTTGGATTTCACAGCCACCATCATCTTCTGGTGGATCCCAGCAAACAGTACACCTATCACT...
pathogenic
49,455
Mutation at chromosome 2, position 178590871, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
CAGGGCGACCAGGTTTATCATACTTGGTTTTGGCTATGACTGGTTTACTTTCTGTTGGAGGCCCTGTGCCTATTTTATTTTCTGCACGGACTCTGAAAATATATTCATTTCCTTCTATGAGACGTGTTACTGTAGTACCAGGTGTCAAGACAGTAGCAGAATAGGTAGACCAAACCATTCGCTTTGTCTCACATTTTTCTAGAATATAATTTTGGATTTCACAGCCACCATCATCTTCTGGTGGATCCCAGCAAACAGTACACCTATCACTGGACACATCAACAATTTTCAGATTTCTCACAGGACCAGGCTTATCTAAA...
CAGGGCGACCAGGTTTATCATACTTGGTTTTGGCTATGACTGGTTTACTTTCTGTTGGAGGCCCTGTGCCTATTTTATTTTCTGCACGGACTCTGAAAATATATTCATTTCCTTCTATGAGACGTGTTACTGTAGTACCAGGTGTCAAGACAGTAGCAGAATAGGTAGACCAAACCATTCGCTTTGTCTCACATTTTTCTAGAATATAATTTTGGATTTCACAGCCACCATCATCTTCTGGTGGATCCCAGCAAACAGTACACCTATCACTGGACACATCAACAATTTTCAGATTTCTCACAGGACCAGGCTTATCTAAA...
pathogenic
49,457
Variant in TTN, chromosome 2, position 178591043—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Tibial_muscular_dystrophy']
AACCATTCGCTTTGTCTCACATTTTTCTAGAATATAATTTTGGATTTCACAGCCACCATCATCTTCTGGTGGATCCCAGCAAACAGTACACCTATCACTGGACACATCAACAATTTTCAGATTTCTCACAGGACCAGGCTTATCTAAAACATTGACAGTGGCATAGGCCACAAAACTGCCAGCCGTGTTAGTTGCCGTAACTACATATTTACCCCCATCACTTCGCTTTGCTTTAGTAAGAGAAAATTTAGATGAATCAGCACGGGTATCAATCTTGACCCTTGGTGATCTTGTTAAGTCTGTAGCGTCTTTGTCCTTGG...
AACCATTCGCTTTGTCTCACATTTTTCTAGAATATAATTTTGGATTTCACAGCCACCATCATCTTCTGGTGGATCCCAGCAAACAGTACACCTATCACTGGACACATCAACAATTTTCAGATTTCTCACAGGACCAGGCTTATCTAAAACATTGACAGTGGCATAGGCCACAAAACTGCCAGCCGTGTTAGTTGCCGTAACTACATATTTACCCCCATCACTTCGCTTTGCTTTAGTAAGAGAAAATTTAGATGAATCAGCACGGGTATCAATCTTGACCCTTGGTGATCTTGTTAAGTCTGTAGCGTCTTTGTCCTTGG...
pathogenic
49,462
Mutation found at chromosome 2 position 178591268, gene TTN: benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Tibial_muscular_dystrophy']
CTTTGCTTTAGTAAGAGAAAATTTAGATGAATCAGCACGGGTATCAATCTTGACCCTTGGTGATCTTGTTAAGTCTGTAGCGTCTTTGTCCTTGGTCCATGCAACTTCTGGGAATGGTTTGCCTCTAACCCCTGCCTCAAGCCTAATGGTGTCCCCTGCTTTGACAGTTAGGACCCCACTTAATTTCAGATCAAGTACTGGTTTTTGTAAGTCTTCTTTCACAACAACTTCCTCTGTCTTCACCCAGTCACTTTCCCCACCTTCATTCTTTGTTTGCACTCTGAACTCATAAATCTGGTTTTCAACACATCTGTCAACCA...
CTTTGCTTTAGTAAGAGAAAATTTAGATGAATCAGCACGGGTATCAATCTTGACCCTTGGTGATCTTGTTAAGTCTGTAGCGTCTTTGTCCTTGGTCCATGCAACTTCTGGGAATGGTTTGCCTCTAACCCCTGCCTCAAGCCTAATGGTGTCCCCTGCTTTGACAGTTAGGACCCCACTTAATTTCAGATCAAGTACTGGTTTTTGTAAGTCTTCTTTCACAACAACTTCCTCTGTCTTCACCCAGTCACTTTCCCCACCTTCATTCTTTGTTTGCACTCTGAACTCATAAATCTGGTTTTCAACACATCTGTCAACCA...
pathogenic
49,473
Assess the variant on chromosome 2, position 178591314, impacting TTN: is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
ATCTTGACCCTTGGTGATCTTGTTAAGTCTGTAGCGTCTTTGTCCTTGGTCCATGCAACTTCTGGGAATGGTTTGCCTCTAACCCCTGCCTCAAGCCTAATGGTGTCCCCTGCTTTGACAGTTAGGACCCCACTTAATTTCAGATCAAGTACTGGTTTTTGTAAGTCTTCTTTCACAACAACTTCCTCTGTCTTCACCCAGTCACTTTCCCCACCTTCATTCTTTGTTTGCACTCTGAACTCATAAATCTGGTTTTCAACACATCTGTCAACCATGTAGTGAGTTTCTTTAATGCTTCCTTTATGCACTCTTTCCCAGTC...
ATCTTGACCCTTGGTGATCTTGTTAAGTCTGTAGCGTCTTTGTCCTTGGTCCATGCAACTTCTGGGAATGGTTTGCCTCTAACCCCTGCCTCAAGCCTAATGGTGTCCCCTGCTTTGACAGTTAGGACCCCACTTAATTTCAGATCAAGTACTGGTTTTTGTAAGTCTTCTTTCACAACAACTTCCTCTGTCTTCACCCAGTCACTTTCCCCACCTTCATTCTTTGTTTGCACTCTGAACTCATAAATCTGGTTTTCAACACATCTGTCAACCATGTAGTGAGTTTCTTTAATGCTTCCTTTATGCACTCTTTCCCAGTC...
pathogenic
49,474
Gene TTN variant at chromosome position 178591325 on chromosome 2: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Cardiomyopathy', 'Primary_dilated_cardiomyopathy']
TGGTGATCTTGTTAAGTCTGTAGCGTCTTTGTCCTTGGTCCATGCAACTTCTGGGAATGGTTTGCCTCTAACCCCTGCCTCAAGCCTAATGGTGTCCCCTGCTTTGACAGTTAGGACCCCACTTAATTTCAGATCAAGTACTGGTTTTTGTAAGTCTTCTTTCACAACAACTTCCTCTGTCTTCACCCAGTCACTTTCCCCACCTTCATTCTTTGTTTGCACTCTGAACTCATAAATCTGGTTTTCAACACATCTGTCAACCATGTAGTGAGTTTCTTTAATGCTTCCTTTATGCACTCTTTCCCAGTCATCGGAGCCCT...
TGGTGATCTTGTTAAGTCTGTAGCGTCTTTGTCCTTGGTCCATGCAACTTCTGGGAATGGTTTGCCTCTAACCCCTGCCTCAAGCCTAATGGTGTCCCCTGCTTTGACAGTTAGGACCCCACTTAATTTCAGATCAAGTACTGGTTTTTGTAAGTCTTCTTTCACAACAACTTCCTCTGTCTTCACCCAGTCACTTTCCCCACCTTCATTCTTTGTTTGCACTCTGAACTCATAAATCTGGTTTTCAACACATCTGTCAACCATGTAGTGAGTTTCTTTAATGCTTCCTTTATGCACTCTTTCCCAGTCATCGGAGCCCT...
pathogenic
49,475
Is the genetic mutation found on chromosome 2 at position 178591439, within the gene TTN, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GACCCCACTTAATTTCAGATCAAGTACTGGTTTTTGTAAGTCTTCTTTCACAACAACTTCCTCTGTCTTCACCCAGTCACTTTCCCCACCTTCATTCTTTGTTTGCACTCTGAACTCATAAATCTGGTTTTCAACACATCTGTCAACCATGTAGTGAGTTTCTTTAATGCTTCCTTTATGCACTCTTTCCCAGTCATCGGAGCCCTTAAGCCTTCTCTCAACATGATATGACAGATTTGGACTGCCACCATCATAGTCAGGCCTCCGCCACTTTAGATAGACAAATGTCTTTCCTTTATCTGCAATGTGAAGGTTTTCAG...
GACCCCACTTAATTTCAGATCAAGTACTGGTTTTTGTAAGTCTTCTTTCACAACAACTTCCTCTGTCTTCACCCAGTCACTTTCCCCACCTTCATTCTTTGTTTGCACTCTGAACTCATAAATCTGGTTTTCAACACATCTGTCAACCATGTAGTGAGTTTCTTTAATGCTTCCTTTATGCACTCTTTCCCAGTCATCGGAGCCCTTAAGCCTTCTCTCAACATGATATGACAGATTTGGACTGCCACCATCATAGTCAGGCCTCCGCCACTTTAGATAGACAAATGTCTTTCCTTTATCTGCAATGTGAAGGTTTTCAG...
pathogenic
49,485
A genetic alteration at chromosome 2, position 178591899, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
TTAGTGACATCTGATGCAACAATTGACCAGCCTTTCTGGTTTGGTTTGCGATATTCTACTATGAAGTTTGTTATTTCTGAGCCACCATTATCTAGTGGGTTTTCCCAAGAAATTGTACAGTTCTCTTTGGTTACATTGGTAACCTTCAAATTCTGGCAAGGCCCAGGTCTGTCAAGGACGTTAACGATGGCTGAACCTTGGGCATGTCCACTGCTGTTCTTAGCTGAGATGATATACTTGCCATGATCAGCTCTAACAGCTTCTTTAATTTGTAACTCAACACGAGGTAGATCCTGAATAAGGTCCACCCTCTTTTCTCG...
TTAGTGACATCTGATGCAACAATTGACCAGCCTTTCTGGTTTGGTTTGCGATATTCTACTATGAAGTTTGTTATTTCTGAGCCACCATTATCTAGTGGGTTTTCCCAAGAAATTGTACAGTTCTCTTTGGTTACATTGGTAACCTTCAAATTCTGGCAAGGCCCAGGTCTGTCAAGGACGTTAACGATGGCTGAACCTTGGGCATGTCCACTGCTGTTCTTAGCTGAGATGATATACTTGCCATGATCAGCTCTAACAGCTTCTTTAATTTGTAACTCAACACGAGGTAGATCCTGAATAAGGTCCACCCTCTTTTCTCG...
benign
49,509
Is the genetic change at chromosome 2, position 178592140, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CATGATCAGCTCTAACAGCTTCTTTAATTTGTAACTCAACACGAGGTAGATCCTGAATAAGGTCCACCCTCTTTTCTCGGACCAATACTTTGCCTTCCTTAGTCCAAGTTATGTCTGGTTCAGGTCTGCCTTTGACTCGAGCTAGAATGCGGATAGTTTGGCCTACTCTCACGGTAATAACATCACGACAAGTAACATCAAGTTCTACTTCTGGAGGATGAAGGATATCTTTTGCAATCACAGATTCTGCTAGTTCTCTTGGCTCACCCTCTCCTACAATATTAGCTGCCTTTATACGGAATCTGTACTCATTTCCTTCA...
CATGATCAGCTCTAACAGCTTCTTTAATTTGTAACTCAACACGAGGTAGATCCTGAATAAGGTCCACCCTCTTTTCTCGGACCAATACTTTGCCTTCCTTAGTCCAAGTTATGTCTGGTTCAGGTCTGCCTTTGACTCGAGCTAGAATGCGGATAGTTTGGCCTACTCTCACGGTAATAACATCACGACAAGTAACATCAAGTTCTACTTCTGGAGGATGAAGGATATCTTTTGCAATCACAGATTCTGCTAGTTCTCTTGGCTCACCCTCTCCTACAATATTAGCTGCCTTTATACGGAATCTGTACTCATTTCCTTCA...
pathogenic
49,519
Regarding the variant found on chromosome 2 at position 178592371 in gene TTN: is it benign or pathogenic? If pathogenic, identify the disease(s).
benign
TTGCAATCACAGATTCTGCTAGTTCTCTTGGCTCACCCTCTCCTACAATATTAGCTGCCTTTATACGGAATCTGTACTCATTTCCTTCAATTAGTCCAGGTACCCTAAAGGCACATTGCCTAATGAGTTCATCTTTATTAATCCTGTTCCATTGTGCTGTGCCAGGTTTCTGACATTCCACTACATATCCTAGAATGGGGCTACCACCATCACTGAGAGGCTTTGTCCACACCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGA...
TTGCAATCACAGATTCTGCTAGTTCTCTTGGCTCACCCTCTCCTACAATATTAGCTGCCTTTATACGGAATCTGTACTCATTTCCTTCAATTAGTCCAGGTACCCTAAAGGCACATTGCCTAATGAGTTCATCTTTATTAATCCTGTTCCATTGTGCTGTGCCAGGTTTCTGACATTCCACTACATATCCTAGAATGGGGCTACCACCATCACTGAGAGGCTTTGTCCACACCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGA...
benign
49,526
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 2, position 178592538, gene TTN. What disease(s) is it linked to if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TTCTGACATTCCACTACATATCCTAGAATGGGGCTACCACCATCACTGAGAGGCTTTGTCCACACCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTA...
TTCTGACATTCCACTACATATCCTAGAATGGGGCTACCACCATCACTGAGAGGCTTTGTCCACACCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTA...
pathogenic
49,531
Clinical classification of chromosome 2, position 178592553, gene TTN: benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
ACATATCCTAGAATGGGGCTACCACCATCACTGAGAGGCTTTGTCCACACCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTAGCCAGTTATTGGACT...
ACATATCCTAGAATGGGGCTACCACCATCACTGAGAGGCTTTGTCCACACCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTAGCCAGTTATTGGACT...
pathogenic
49,533
A genetic alteration at chromosome 2, position 178592593, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
TTGTCCACACCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTAGCCAGTTATTGGACTGCCACCATCAGATTTTGGCAGGGTCCAAGACACTGTTGCT...
TTGTCCACACCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTAGCCAGTTATTGGACTGCCACCATCAGATTTTGGCAGGGTCCAAGACACTGTTGCT...
pathogenic
49,535
Considering the variant on chromosome 2, location 178592602, involving gene TTN, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTAGCCAGTTATTGGACTGCCACCATCAGATTTTGGCAGGGTCCAAGACACTGTTGCTGCATTTTCA...
CCAAATCAGCTGTTTCTCTGCTCTTGTCTTTCAGTTTAGGATTAATAGGTGGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTAGCCAGTTATTGGACTGCCACCATCAGATTTTGGCAGGGTCCAAGACACTGTTGCTGCATTTTCA...
pathogenic
49,536
Regarding the variant found on chromosome 2 at position 178592652 in gene TTN: is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTAGCCAGTTATTGGACTGCCACCATCAGATTTTGGCAGGGTCCAAGACACTGTTGCTGCATTTTCAGTAATGTCAGTAACCACTGGTTTACCAGGAGGAGACGGAGGACTAAATTT...
GGTCCAGGTGGTTTGATGGGCCGGCAAGCTTTTATTGGATCAGAACTTGGGGATGGTTTGCTTAGTCCTGCAAGATTTTCAGCAAAAACTCTAAACTCATATGTATTTCCTTCATAGAGTCCAGTCACTCTGAACTTCAGGTCAGCGATAGGTGTTTTGTTGACCCTCACCCATTTGCCAGTTACTTCTCGACGTTCCATATAGTAGCCAGTTATTGGACTGCCACCATCAGATTTTGGCAGGGTCCAAGACACTGTTGCTGCATTTTCAGTAATGTCAGTAACCACTGGTTTACCAGGAGGAGACGGAGGACTAAATTT...
pathogenic
49,539
Regarding the variant at chromosome 2 and position 178592913, affecting gene TTN: benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy', 'TTN-related_disorder']
GCATTTTCAGTAATGTCAGTAACCACTGGTTTACCAGGAGGAGACGGAGGACTAAATTTATGCTTAGCAACAGTAGGTGTGGAGTCAAGGGGAGGACCAACACCTATCTTATTCTCTGCTCTAACTCGGAAAACATATTCACAGCCCTTCTGCAGATGTGGGATTTTCAGCTTTGTCTTACTGCTTCCGGAAGAGACAACACCCCACGTGTCTTTCCTTGTATCTTGTTTCTCAACAATATAATTTATCACAGGGCTTCCTCCATCATCCTTAGGTGGCTGCCATGAGATAGTCATGTGTTCAGGAGTAACATCCAGAAT...
GCATTTTCAGTAATGTCAGTAACCACTGGTTTACCAGGAGGAGACGGAGGACTAAATTTATGCTTAGCAACAGTAGGTGTGGAGTCAAGGGGAGGACCAACACCTATCTTATTCTCTGCTCTAACTCGGAAAACATATTCACAGCCCTTCTGCAGATGTGGGATTTTCAGCTTTGTCTTACTGCTTCCGGAAGAGACAACACCCCACGTGTCTTTCCTTGTATCTTGTTTCTCAACAATATAATTTATCACAGGGCTTCCTCCATCATCCTTAGGTGGCTGCCATGAGATAGTCATGTGTTCAGGAGTAACATCCAGAAT...
pathogenic
49,547
Variant in gene TTN, located at chromosome 2 position 178592916: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Tibial_muscular_dystrophy']
TTTTCAGTAATGTCAGTAACCACTGGTTTACCAGGAGGAGACGGAGGACTAAATTTATGCTTAGCAACAGTAGGTGTGGAGTCAAGGGGAGGACCAACACCTATCTTATTCTCTGCTCTAACTCGGAAAACATATTCACAGCCCTTCTGCAGATGTGGGATTTTCAGCTTTGTCTTACTGCTTCCGGAAGAGACAACACCCCACGTGTCTTTCCTTGTATCTTGTTTCTCAACAATATAATTTATCACAGGGCTTCCTCCATCATCCTTAGGTGGCTGCCATGAGATAGTCATGTGTTCAGGAGTAACATCCAGAATATT...
TTTTCAGTAATGTCAGTAACCACTGGTTTACCAGGAGGAGACGGAGGACTAAATTTATGCTTAGCAACAGTAGGTGTGGAGTCAAGGGGAGGACCAACACCTATCTTATTCTCTGCTCTAACTCGGAAAACATATTCACAGCCCTTCTGCAGATGTGGGATTTTCAGCTTTGTCTTACTGCTTCCGGAAGAGACAACACCCCACGTGTCTTTCCTTGTATCTTGTTTCTCAACAATATAATTTATCACAGGGCTTCCTCCATCATCCTTAGGTGGCTGCCATGAGATAGTCATGTGTTCAGGAGTAACATCCAGAATATT...
pathogenic
49,548
Variant on chromosome 2, at position 178592991, affecting TTN: is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GTGGAGTCAAGGGGAGGACCAACACCTATCTTATTCTCTGCTCTAACTCGGAAAACATATTCACAGCCCTTCTGCAGATGTGGGATTTTCAGCTTTGTCTTACTGCTTCCGGAAGAGACAACACCCCACGTGTCTTTCCTTGTATCTTGTTTCTCAACAATATAATTTATCACAGGGCTTCCTCCATCATCCTTAGGTGGCTGCCATGAGATAGTCATGTGTTCAGGAGTAACATCCAGAATATTAATAGGACCTGTTGGTGGCCCAGGAACATCAAGAACAGTAAGATGTACGGCTACTGTTTTGCTACCGGCTGCATT...
GTGGAGTCAAGGGGAGGACCAACACCTATCTTATTCTCTGCTCTAACTCGGAAAACATATTCACAGCCCTTCTGCAGATGTGGGATTTTCAGCTTTGTCTTACTGCTTCCGGAAGAGACAACACCCCACGTGTCTTTCCTTGTATCTTGTTTCTCAACAATATAATTTATCACAGGGCTTCCTCCATCATCCTTAGGTGGCTGCCATGAGATAGTCATGTGTTCAGGAGTAACATCCAGAATATTAATAGGACCTGTTGGTGGCCCAGGAACATCAAGAACAGTAAGATGTACGGCTACTGTTTTGCTACCGGCTGCATT...
pathogenic
49,555
Is the genetic change at chromosome 2, position 178593369, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Cardiovascular_phenotype', 'Primary_dilated_cardiomyopathy']
ACTGATGAGAAGTTGTCTGTTTCAACTGTGTAGTGCTCATCGGTTTTAATCTCACTCCCATCGGTTGTCCACTTTGCAGTAGGAACAGGCACACCTCTTATAATAGCAGGGAATCTGACTGTGGTTCCAGCCTTTACCACAAGACCTTCAATTAATTTCACATCTAGCTCCACGGATGGAGGCACTGAAAAGTAAACATGAAAAAATTAGATTTTGATTTTCACCTATATGAATAATTTTAAAAAGAAATAAGGTAATACTGCTAGTCCAAAAATTACCTAGTTTTTCTTGACATTCTATCGGGATAGTTGTGTCAGGGA...
ACTGATGAGAAGTTGTCTGTTTCAACTGTGTAGTGCTCATCGGTTTTAATCTCACTCCCATCGGTTGTCCACTTTGCAGTAGGAACAGGCACACCTCTTATAATAGCAGGGAATCTGACTGTGGTTCCAGCCTTTACCACAAGACCTTCAATTAATTTCACATCTAGCTCCACGGATGGAGGCACTGAAAAGTAAACATGAAAAAATTAGATTTTGATTTTCACCTATATGAATAATTTTAAAAAGAAATAAGGTAATACTGCTAGTCCAAAAATTACCTAGTTTTTCTTGACATTCTATCGGGATAGTTGTGTCAGGGA...
pathogenic
49,569
Is the genetic mutation found on chromosome 2 at position 178593679, within the gene TTN, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GTGTCAGGGAGACCAAGACCCACAATGTTTTCAGCTTTTACACGGAATCTATAGGTCTTTCCTTGTTGTAGTCCAGTAACCACACACTCTAAGTTTGTCACAGTCTTAAATTTAATCCAGTCCTGGGTGCCTTCTTCTTGATATTCTACCAAATATCCAGTGATTGGAGAACCACCATCACGATCCGGCTTATTCCAGACTAGGGAGACTTCAGTCTTGTCAACATCTACATGGTGCAGGTCCTTGGGTGGCCCTGGGGGATCTTTTCAAAGAAGAAGTTATGATGAAAAAGTAATATTCTTAAAGACAGTCAAACAATA...
GTGTCAGGGAGACCAAGACCCACAATGTTTTCAGCTTTTACACGGAATCTATAGGTCTTTCCTTGTTGTAGTCCAGTAACCACACACTCTAAGTTTGTCACAGTCTTAAATTTAATCCAGTCCTGGGTGCCTTCTTCTTGATATTCTACCAAATATCCAGTGATTGGAGAACCACCATCACGATCCGGCTTATTCCAGACTAGGGAGACTTCAGTCTTGTCAACATCTACATGGTGCAGGTCCTTGGGTGGCCCTGGGGGATCTTTTCAAAGAAGAAGTTATGATGAAAAAGTAATATTCTTAAAGACAGTCAAACAATA...
pathogenic
49,578
A genetic alteration at chromosome 2, position 178593731, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AGGTCTTTCCTTGTTGTAGTCCAGTAACCACACACTCTAAGTTTGTCACAGTCTTAAATTTAATCCAGTCCTGGGTGCCTTCTTCTTGATATTCTACCAAATATCCAGTGATTGGAGAACCACCATCACGATCCGGCTTATTCCAGACTAGGGAGACTTCAGTCTTGTCAACATCTACATGGTGCAGGTCCTTGGGTGGCCCTGGGGGATCTTTTCAAAGAAGAAGTTATGATGAAAAAGTAATATTCTTAAAGACAGTCAAACAATAGTTTTGTATTCAGAGAAAGCAACTTACGGAGAGGATCCAAAGCCTTGATTGG...
AGGTCTTTCCTTGTTGTAGTCCAGTAACCACACACTCTAAGTTTGTCACAGTCTTAAATTTAATCCAGTCCTGGGTGCCTTCTTCTTGATATTCTACCAAATATCCAGTGATTGGAGAACCACCATCACGATCCGGCTTATTCCAGACTAGGGAGACTTCAGTCTTGTCAACATCTACATGGTGCAGGTCCTTGGGTGGCCCTGGGGGATCTTTTCAAAGAAGAAGTTATGATGAAAAAGTAATATTCTTAAAGACAGTCAAACAATAGTTTTGTATTCAGAGAAAGCAACTTACGGAGAGGATCCAAAGCCTTGATTGG...
pathogenic
49,581
A genetic variant on chromosome 2, position 178593819, affects the gene TTN. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ATATTCTACCAAATATCCAGTGATTGGAGAACCACCATCACGATCCGGCTTATTCCAGACTAGGGAGACTTCAGTCTTGTCAACATCTACATGGTGCAGGTCCTTGGGTGGCCCTGGGGGATCTTTTCAAAGAAGAAGTTATGATGAAAAAGTAATATTCTTAAAGACAGTCAAACAATAGTTTTGTATTCAGAGAAAGCAACTTACGGAGAGGATCCAAAGCCTTGATTGGTTTTGGTGTTTCAACAAAAGGACCACGTCCATACTGGTTCTCCGCAGCTACTCGGAAGAGGTACTGGTTGCCTTCATTCAGATGCTTA...
ATATTCTACCAAATATCCAGTGATTGGAGAACCACCATCACGATCCGGCTTATTCCAGACTAGGGAGACTTCAGTCTTGTCAACATCTACATGGTGCAGGTCCTTGGGTGGCCCTGGGGGATCTTTTCAAAGAAGAAGTTATGATGAAAAAGTAATATTCTTAAAGACAGTCAAACAATAGTTTTGTATTCAGAGAAAGCAACTTACGGAGAGGATCCAAAGCCTTGATTGGTTTTGGTGTTTCAACAAAAGGACCACGTCCATACTGGTTCTCCGCAGCTACTCGGAAGAGGTACTGGTTGCCTTCATTCAGATGCTTA...
pathogenic
49,583
Considering the genetic mutation at chromosome 2, position 178594216, impacting TTN: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
ATAATTGGTAATAACAGAACCACCATCATCCAGTGGTTCTTTCCAAGTAAGGTAACATGAATCTTTCCTAATTTCACTGACTTCCAGATCTCTAGGTGGCCCAGGTTTATCTAAAAAGTGTTAAATAACAGTTTGATAAGTAATTTTATCCATATAAGAGCTCAAAATTATCAAAATTTATTTTTAATGGCCTAAGTAGTAAAATTCTTACCTAATACAAGTACTTTTACTGAGACAGTTTTTGAACCAGCTGGATTCTCCACTGTTAAAGAATAAATTCCACCATCTTCATGGGCAGCATTACGAATTTCAAGCTTGCT...
ATAATTGGTAATAACAGAACCACCATCATCCAGTGGTTCTTTCCAAGTAAGGTAACATGAATCTTTCCTAATTTCACTGACTTCCAGATCTCTAGGTGGCCCAGGTTTATCTAAAAAGTGTTAAATAACAGTTTGATAAGTAATTTTATCCATATAAGAGCTCAAAATTATCAAAATTTATTTTTAATGGCCTAAGTAGTAAAATTCTTACCTAATACAAGTACTTTTACTGAGACAGTTTTTGAACCAGCTGGATTCTCCACTGTTAAAGAATAAATTCCACCATCTTCATGGGCAGCATTACGAATTTCAAGCTTGCT...
pathogenic
49,601
Variant in gene TTN, located at chromosome 2 position 178594376: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CTCAAAATTATCAAAATTTATTTTTAATGGCCTAAGTAGTAAAATTCTTACCTAATACAAGTACTTTTACTGAGACAGTTTTTGAACCAGCTGGATTCTCCACTGTTAAAGAATAAATTCCACCATCTTCATGGGCAGCATTACGAATTTCAAGCTTGCTACCAACTGGAGTCACATCAATTCTTGCTTTAGTTGGAGCATCTCTGTCTTCTTTTTTCCAAGTTACTTTTGGGAATGGCACTCCTTTGATGATGGCACTAAGTCTTAGAGTATCACCAACTTTAATGTGTTGTTCTCTTGCCATGTTGGCATCAAGAATC...
CTCAAAATTATCAAAATTTATTTTTAATGGCCTAAGTAGTAAAATTCTTACCTAATACAAGTACTTTTACTGAGACAGTTTTTGAACCAGCTGGATTCTCCACTGTTAAAGAATAAATTCCACCATCTTCATGGGCAGCATTACGAATTTCAAGCTTGCTACCAACTGGAGTCACATCAATTCTTGCTTTAGTTGGAGCATCTCTGTCTTCTTTTTTCCAAGTTACTTTTGGGAATGGCACTCCTTTGATGATGGCACTAAGTCTTAGAGTATCACCAACTTTAATGTGTTGTTCTCTTGCCATGTTGGCATCAAGAATC...
pathogenic
49,606
Does the chromosome 2 mutation at position 178594498 within gene TTN classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Cardiomyopathy', 'Primary_dilated_cardiomyopathy']
CCATCTTCATGGGCAGCATTACGAATTTCAAGCTTGCTACCAACTGGAGTCACATCAATTCTTGCTTTAGTTGGAGCATCTCTGTCTTCTTTTTTCCAAGTTACTTTTGGGAATGGCACTCCTTTGATGATGGCACTAAGTCTTAGAGTATCACCAACTTTAATGTGTTGTTCTCTTGCCATGTTGGCATCAAGAATCAACTCAGGGGGTTCTAGAATAAAGAGAACAGAACACTCAGATTTGATCCATAATGCAGATTACAATTAAACACATACAATCAGACATCTATTTTCCTTGCAAACACAAGTGAGAGCATTTTA...
CCATCTTCATGGGCAGCATTACGAATTTCAAGCTTGCTACCAACTGGAGTCACATCAATTCTTGCTTTAGTTGGAGCATCTCTGTCTTCTTTTTTCCAAGTTACTTTTGGGAATGGCACTCCTTTGATGATGGCACTAAGTCTTAGAGTATCACCAACTTTAATGTGTTGTTCTCTTGCCATGTTGGCATCAAGAATCAACTCAGGGGGTTCTAGAATAAAGAGAACAGAACACTCAGATTTGATCCATAATGCAGATTACAATTAAACACATACAATCAGACATCTATTTTCCTTGCAAACACAAGTGAGAGCATTTTA...
pathogenic
49,609
Is the variant located on chromosome 2 at position 178594639, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CTTAGAGTATCACCAACTTTAATGTGTTGTTCTCTTGCCATGTTGGCATCAAGAATCAACTCAGGGGGTTCTAGAATAAAGAGAACAGAACACTCAGATTTGATCCATAATGCAGATTACAATTAAACACATACAATCAGACATCTATTTTCCTTGCAAACACAAGTGAGAGCATTTTACTCACCAAGCCTGTCTTTTACTAGGACTGGCTCCGGAACATGAGCTGGATCTGATTCACCAGCTGCATTGACTGCTAACACTCTAAACTTATAGGTTTGACCGTCCCGAAGACCGGTGACTTTATATTTAGTTTCAGGACA...
CTTAGAGTATCACCAACTTTAATGTGTTGTTCTCTTGCCATGTTGGCATCAAGAATCAACTCAGGGGGTTCTAGAATAAAGAGAACAGAACACTCAGATTTGATCCATAATGCAGATTACAATTAAACACATACAATCAGACATCTATTTTCCTTGCAAACACAAGTGAGAGCATTTTACTCACCAAGCCTGTCTTTTACTAGGACTGGCTCCGGAACATGAGCTGGATCTGATTCACCAGCTGCATTGACTGCTAACACTCTAAACTTATAGGTTTGACCGTCCCGAAGACCGGTGACTTTATATTTAGTTTCAGGACA...
pathogenic
49,614
Clinical classification of chromosome 2, position 178594644, gene TTN: benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AGTATCACCAACTTTAATGTGTTGTTCTCTTGCCATGTTGGCATCAAGAATCAACTCAGGGGGTTCTAGAATAAAGAGAACAGAACACTCAGATTTGATCCATAATGCAGATTACAATTAAACACATACAATCAGACATCTATTTTCCTTGCAAACACAAGTGAGAGCATTTTACTCACCAAGCCTGTCTTTTACTAGGACTGGCTCCGGAACATGAGCTGGATCTGATTCACCAGCTGCATTGACTGCTAACACTCTAAACTTATAGGTTTGACCGTCCCGAAGACCGGTGACTTTATATTTAGTTTCAGGACATGACT...
AGTATCACCAACTTTAATGTGTTGTTCTCTTGCCATGTTGGCATCAAGAATCAACTCAGGGGGTTCTAGAATAAAGAGAACAGAACACTCAGATTTGATCCATAATGCAGATTACAATTAAACACATACAATCAGACATCTATTTTCCTTGCAAACACAAGTGAGAGCATTTTACTCACCAAGCCTGTCTTTTACTAGGACTGGCTCCGGAACATGAGCTGGATCTGATTCACCAGCTGCATTGACTGCTAACACTCTAAACTTATAGGTTTGACCGTCCCGAAGACCGGTGACTTTATATTTAGTTTCAGGACATGACT...
pathogenic
49,615
Is the genetic mutation found on chromosome 2 at position 178595487, within the gene TTN, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
benign
TCTGTAACAATTGGCTGATCAGGTGCATCAGGAACCCCTGTAACAAATGTTGGAAAATGCGTTAGAAATTTATTTCTTTATATTAGTTTTATCAAGCATTGAATCACTAAAAAGAAACATAATGCATACTGAAACGATCTTTGGCTTTCATTGAATCAGACACCAGAGGATCACTTATTCCATACAGATTTTCAGCATGTATCCGGAAAATATAATCTTTTCCTTCAAGTAGTTTAGAAACTTTGCATGTTGTTTTAGCACTTGCAGATGTCACTGGCATCCAGACGTCTTTACCCACTTCCTTCTTCTCAATAATATAA...
TCTGTAACAATTGGCTGATCAGGTGCATCAGGAACCCCTGTAACAAATGTTGGAAAATGCGTTAGAAATTTATTTCTTTATATTAGTTTTATCAAGCATTGAATCACTAAAAAGAAACATAATGCATACTGAAACGATCTTTGGCTTTCATTGAATCAGACACCAGAGGATCACTTATTCCATACAGATTTTCAGCATGTATCCGGAAAATATAATCTTTTCCTTCAAGTAGTTTAGAAACTTTGCATGTTGTTTTAGCACTTGCAGATGTCACTGGCATCCAGACGTCTTTACCCACTTCCTTCTTCTCAATAATATAA...
benign
49,618
Variant chromosome 2, position 178595487, gene TTN: benign or pathogenic? Disease(s)?
benign
TCTGTAACAATTGGCTGATCAGGTGCATCAGGAACCCCTGTAACAAATGTTGGAAAATGCGTTAGAAATTTATTTCTTTATATTAGTTTTATCAAGCATTGAATCACTAAAAAGAAACATAATGCATACTGAAACGATCTTTGGCTTTCATTGAATCAGACACCAGAGGATCACTTATTCCATACAGATTTTCAGCATGTATCCGGAAAATATAATCTTTTCCTTCAAGTAGTTTAGAAACTTTGCATGTTGTTTTAGCACTTGCAGATGTCACTGGCATCCAGACGTCTTTACCCACTTCCTTCTTCTCAATAATATAA...
TCTGTAACAATTGGCTGATCAGGTGCATCAGGAACCCCTGTAACAAATGTTGGAAAATGCGTTAGAAATTTATTTCTTTATATTAGTTTTATCAAGCATTGAATCACTAAAAAGAAACATAATGCATACTGAAACGATCTTTGGCTTTCATTGAATCAGACACCAGAGGATCACTTATTCCATACAGATTTTCAGCATGTATCCGGAAAATATAATCTTTTCCTTCAAGTAGTTTAGAAACTTTGCATGTTGTTTTAGCACTTGCAGATGTCACTGGCATCCAGACGTCTTTACCCACTTCCTTCTTCTCAATAATATAA...
benign
49,619
The chromosome 2, position 178595795 genetic variant in gene TTN: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TCAATAATATAATTGGTGATTTTACTGCCTCCATCATCTAAAGGAGGCTTCCAAGAGATAACCATGTAATCTTTGGTCACCTCATCAAAACTAACTGGTCCTACTGGTGGTCCAGGACGGTCTGCAGAAAAAAAAAATCATGGCACAAAATGTTATTGCCATTTCTGCTTTTGAAAGAACAGAAGATCTATTCTTTCCACTAAATAAGACTTACCAACAACATTAACTTGACAGAAACCTTTCCTAGAGCCTGTACTGTTCTCCACAACCACACAGTATTTGCCGGAATCTGAACGTTTGGCCTTGATCTTCTCTAAAGC...
TCAATAATATAATTGGTGATTTTACTGCCTCCATCATCTAAAGGAGGCTTCCAAGAGATAACCATGTAATCTTTGGTCACCTCATCAAAACTAACTGGTCCTACTGGTGGTCCAGGACGGTCTGCAGAAAAAAAAAATCATGGCACAAAATGTTATTGCCATTTCTGCTTTTGAAAGAACAGAAGATCTATTCTTTCCACTAAATAAGACTTACCAACAACATTAACTTGACAGAAACCTTTCCTAGAGCCTGTACTGTTCTCCACAACCACACAGTATTTGCCGGAATCTGAACGTTTGGCCTTGATCTTCTCTAAAGC...
pathogenic
49,631
Does the genetic variant at chromosome 2, position 178595817, impacting gene TTN, appear benign or pathogenic? If pathogenic, name the associated disease(s).
benign
TACTGCCTCCATCATCTAAAGGAGGCTTCCAAGAGATAACCATGTAATCTTTGGTCACCTCATCAAAACTAACTGGTCCTACTGGTGGTCCAGGACGGTCTGCAGAAAAAAAAAATCATGGCACAAAATGTTATTGCCATTTCTGCTTTTGAAAGAACAGAAGATCTATTCTTTCCACTAAATAAGACTTACCAACAACATTAACTTGACAGAAACCTTTCCTAGAGCCTGTACTGTTCTCCACAACCACACAGTATTTGCCGGAATCTGAACGTTTGGCCTTGATCTTCTCTAAAGCAAGTGTTGCTGGTGTAGTCTTT...
TACTGCCTCCATCATCTAAAGGAGGCTTCCAAGAGATAACCATGTAATCTTTGGTCACCTCATCAAAACTAACTGGTCCTACTGGTGGTCCAGGACGGTCTGCAGAAAAAAAAAATCATGGCACAAAATGTTATTGCCATTTCTGCTTTTGAAAGAACAGAAGATCTATTCTTTCCACTAAATAAGACTTACCAACAACATTAACTTGACAGAAACCTTTCCTAGAGCCTGTACTGTTCTCCACAACCACACAGTATTTGCCGGAATCTGAACGTTTGGCCTTGATCTTCTCTAAAGCAAGTGTTGCTGGTGTAGTCTTT...
benign
49,634
Gene mutation in TTN at chromosome 2, position 178597618—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
TTTCAGCCGCAATTCGGAAAAAGTAGGCTTTTCCTTGAATGAGACCCTGGACAGTAGCATTTTGTCGGGTAACTGTATATGTCACTGGGGTCCATGCTCTGCGGTCAGATTCACGCTTTTCAATGACATAATTGGTGATTGGAGAGCCTCCATCATCTTCTGGAGAAAACCATGTCAGTTTGCAGGACTCATTGGTTAGGTTGTGAGCTAGGAATGGTGTTCCAACGGGACCTGGAACATCTGGAAATAAGAAGAAAATAATTCAAGCTGTTTGCCTTCAATGAAAGATAATGCTCAACACTTGTTTTTTTAAAAGGAGA...
TTTCAGCCGCAATTCGGAAAAAGTAGGCTTTTCCTTGAATGAGACCCTGGACAGTAGCATTTTGTCGGGTAACTGTATATGTCACTGGGGTCCATGCTCTGCGGTCAGATTCACGCTTTTCAATGACATAATTGGTGATTGGAGAGCCTCCATCATCTTCTGGAGAAAACCATGTCAGTTTGCAGGACTCATTGGTTAGGTTGTGAGCTAGGAATGGTGTTCCAACGGGACCTGGAACATCTGGAAATAAGAAGAAAATAATTCAAGCTGTTTGCCTTCAATGAAAGATAATGCTCAACACTTGTTTTTTTAAAAGGAGA...
benign
49,639
Does the variant on chromosome 2 at location 178597747 affecting gene TTN have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AATTGGTGATTGGAGAGCCTCCATCATCTTCTGGAGAAAACCATGTCAGTTTGCAGGACTCATTGGTTAGGTTGTGAGCTAGGAATGGTGTTCCAACGGGACCTGGAACATCTGGAAATAAGAAGAAAATAATTCAAGCTGTTTGCCTTCAATGAAAGATAATGCTCAACACTTGTTTTTTTAAAAGGAGACAAAAATGTTGTTTTGAAGAAAGTAAGGTTTTGTGTCTACTAATTGAGTTAGTTTTTCCTTCTGCTATCTAGTCAATACAAAAACAGTCAACCACTTTTTTTTTTTTTTTTTTTTTTTGAGATGGGAGT...
AATTGGTGATTGGAGAGCCTCCATCATCTTCTGGAGAAAACCATGTCAGTTTGCAGGACTCATTGGTTAGGTTGTGAGCTAGGAATGGTGTTCCAACGGGACCTGGAACATCTGGAAATAAGAAGAAAATAATTCAAGCTGTTTGCCTTCAATGAAAGATAATGCTCAACACTTGTTTTTTTAAAAGGAGACAAAAATGTTGTTTTGAAGAAAGTAAGGTTTTGTGTCTACTAATTGAGTTAGTTTTTCCTTCTGCTATCTAGTCAATACAAAAACAGTCAACCACTTTTTTTTTTTTTTTTTTTTTTTGAGATGGGAGT...
pathogenic
49,647
Evaluate if the mutation on chromosome 2 at position 178597778 in TTN is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TGGAGAAAACCATGTCAGTTTGCAGGACTCATTGGTTAGGTTGTGAGCTAGGAATGGTGTTCCAACGGGACCTGGAACATCTGGAAATAAGAAGAAAATAATTCAAGCTGTTTGCCTTCAATGAAAGATAATGCTCAACACTTGTTTTTTTAAAAGGAGACAAAAATGTTGTTTTGAAGAAAGTAAGGTTTTGTGTCTACTAATTGAGTTAGTTTTTCCTTCTGCTATCTAGTCAATACAAAAACAGTCAACCACTTTTTTTTTTTTTTTTTTTTTTTGAGATGGGAGTCTCGCTCTGTCACCCAGGCTGGAGTTCAGTG...
TGGAGAAAACCATGTCAGTTTGCAGGACTCATTGGTTAGGTTGTGAGCTAGGAATGGTGTTCCAACGGGACCTGGAACATCTGGAAATAAGAAGAAAATAATTCAAGCTGTTTGCCTTCAATGAAAGATAATGCTCAACACTTGTTTTTTTAAAAGGAGACAAAAATGTTGTTTTGAAGAAAGTAAGGTTTTGTGTCTACTAATTGAGTTAGTTTTTCCTTCTGCTATCTAGTCAATACAAAAACAGTCAACCACTTTTTTTTTTTTTTTTTTTTTTTGAGATGGGAGTCTCGCTCTGTCACCCAGGCTGGAGTTCAGTG...
pathogenic
49,650
Determine if the mutation at chromosome 2, position 178598042 in gene TTN is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTTTTTTTTTTTTTGAGATGGGAGTCTCGCTCTGTCACCCAGGCTGGAGTTCAGTGGCACAATCTCAGCTCACTGCAACCTCCGCTTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCATACCAGGCTAATTTTTGCATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCTGCCTTGGCCTCCCAAAGTCAGGGGATTACAGGTGTGAGCCATAGCATCAAGCCCCATATTTGTTAATGAAGTAGGT...
TTTTTTTTTTTTTTGAGATGGGAGTCTCGCTCTGTCACCCAGGCTGGAGTTCAGTGGCACAATCTCAGCTCACTGCAACCTCCGCTTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCATACCAGGCTAATTTTTGCATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCTGCCTTGGCCTCCCAAAGTCAGGGGATTACAGGTGTGAGCCATAGCATCAAGCCCCATATTTGTTAATGAAGTAGGT...
pathogenic
49,657
Determine whether the variant at chromosome 2, position 178598559, in gene TTN is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
TATTTCTGGATGACCAGTGGATCAACAAGCAGCATAGGAGGCCCCAAATTTCAGAATGACTTTGAGGAGGTTGCAAATAATTAACGTGGAAATGTACCAGTTCTCAAATTAAAGTAATAACCATTAGGCAAAAGAGCTTTAGGTGCTTGAAACTAACCTGAAAGTTTGTGGGGCTACTGCTTAATGAAATATTTTTCCTTATGCCATTCTTATATTAATTATATTCAACATAGAACTGGCAATTTTCACATAAAAACTGTGGCTGGAGTATTGTTGTGCCTAGAGACATGCTTAGAAAGAGCCCTGAGTGGAAAGGCTTC...
TATTTCTGGATGACCAGTGGATCAACAAGCAGCATAGGAGGCCCCAAATTTCAGAATGACTTTGAGGAGGTTGCAAATAATTAACGTGGAAATGTACCAGTTCTCAAATTAAAGTAATAACCATTAGGCAAAAGAGCTTTAGGTGCTTGAAACTAACCTGAAAGTTTGTGGGGCTACTGCTTAATGAAATATTTTTCCTTATGCCATTCTTATATTAATTATATTCAACATAGAACTGGCAATTTTCACATAAAAACTGTGGCTGGAGTATTGTTGTGCCTAGAGACATGCTTAGAAAGAGCCCTGAGTGGAAAGGCTTC...
pathogenic
49,661
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 2, position 178598672, gene TTN. What disease(s) is it linked to if pathogenic?
benign
GTAATAACCATTAGGCAAAAGAGCTTTAGGTGCTTGAAACTAACCTGAAAGTTTGTGGGGCTACTGCTTAATGAAATATTTTTCCTTATGCCATTCTTATATTAATTATATTCAACATAGAACTGGCAATTTTCACATAAAAACTGTGGCTGGAGTATTGTTGTGCCTAGAGACATGCTTAGAAAGAGCCCTGAGTGGAAAGGCTTCGTGTTCTGAGCAAATCACTGGACTAAAGCCTCCAGTGAGAGCCATGAAAAAGCCTCATAGAGTTCAACTCTATATTCAGTGACTAGAAATGCAATATTGATAACCAACTATGA...
GTAATAACCATTAGGCAAAAGAGCTTTAGGTGCTTGAAACTAACCTGAAAGTTTGTGGGGCTACTGCTTAATGAAATATTTTTCCTTATGCCATTCTTATATTAATTATATTCAACATAGAACTGGCAATTTTCACATAAAAACTGTGGCTGGAGTATTGTTGTGCCTAGAGACATGCTTAGAAAGAGCCCTGAGTGGAAAGGCTTCGTGTTCTGAGCAAATCACTGGACTAAAGCCTCCAGTGAGAGCCATGAAAAAGCCTCATAGAGTTCAACTCTATATTCAGTGACTAGAAATGCAATATTGATAACCAACTATGA...
benign
49,666
Gene mutation in TTN at chromosome 2, position 178598719—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
AAAGTTTGTGGGGCTACTGCTTAATGAAATATTTTTCCTTATGCCATTCTTATATTAATTATATTCAACATAGAACTGGCAATTTTCACATAAAAACTGTGGCTGGAGTATTGTTGTGCCTAGAGACATGCTTAGAAAGAGCCCTGAGTGGAAAGGCTTCGTGTTCTGAGCAAATCACTGGACTAAAGCCTCCAGTGAGAGCCATGAAAAAGCCTCATAGAGTTCAACTCTATATTCAGTGACTAGAAATGCAATATTGATAACCAACTATGATGCTTCTCTTCAATTAGAATACTGAAACCCTTCAAACAGGTTTTTGC...
AAAGTTTGTGGGGCTACTGCTTAATGAAATATTTTTCCTTATGCCATTCTTATATTAATTATATTCAACATAGAACTGGCAATTTTCACATAAAAACTGTGGCTGGAGTATTGTTGTGCCTAGAGACATGCTTAGAAAGAGCCCTGAGTGGAAAGGCTTCGTGTTCTGAGCAAATCACTGGACTAAAGCCTCCAGTGAGAGCCATGAAAAAGCCTCATAGAGTTCAACTCTATATTCAGTGACTAGAAATGCAATATTGATAACCAACTATGATGCTTCTCTTCAATTAGAATACTGAAACCCTTCAAACAGGTTTTTGC...
benign
49,668
Clinical classification of chromosome 2, position 178598856, gene TTN: benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AGAGCCCTGAGTGGAAAGGCTTCGTGTTCTGAGCAAATCACTGGACTAAAGCCTCCAGTGAGAGCCATGAAAAAGCCTCATAGAGTTCAACTCTATATTCAGTGACTAGAAATGCAATATTGATAACCAACTATGATGCTTCTCTTCAATTAGAATACTGAAACCCTTCAAACAGGTTTTTGCATTATTATGATAATTTAGCGATAGGGGTAGAGTCTCATGATGTGAAATGGTCAGCACTGGCAAATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCAGATTGTTAAACATTCATGTACAGTTTAAGGAAAGTT...
AGAGCCCTGAGTGGAAAGGCTTCGTGTTCTGAGCAAATCACTGGACTAAAGCCTCCAGTGAGAGCCATGAAAAAGCCTCATAGAGTTCAACTCTATATTCAGTGACTAGAAATGCAATATTGATAACCAACTATGATGCTTCTCTTCAATTAGAATACTGAAACCCTTCAAACAGGTTTTTGCATTATTATGATAATTTAGCGATAGGGGTAGAGTCTCATGATGTGAAATGGTCAGCACTGGCAAATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCAGATTGTTAAACATTCATGTACAGTTTAAGGAAAGTT...
pathogenic
49,672
Determine if the mutation at chromosome 2, position 178598968 in gene TTN is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G']
TGCAATATTGATAACCAACTATGATGCTTCTCTTCAATTAGAATACTGAAACCCTTCAAACAGGTTTTTGCATTATTATGATAATTTAGCGATAGGGGTAGAGTCTCATGATGTGAAATGGTCAGCACTGGCAAATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCAGATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCTTCTATGAAAACTATATAACAACATAATAGACACTATGGGGGCAAGTTCTATAAAAAAGCCATATTTATTCTGGGCCATGATTCAGAATACATATTCATGGCCTTCTAGC...
TGCAATATTGATAACCAACTATGATGCTTCTCTTCAATTAGAATACTGAAACCCTTCAAACAGGTTTTTGCATTATTATGATAATTTAGCGATAGGGGTAGAGTCTCATGATGTGAAATGGTCAGCACTGGCAAATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCAGATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCTTCTATGAAAACTATATAACAACATAATAGACACTATGGGGGCAAGTTCTATAAAAAAGCCATATTTATTCTGGGCCATGATTCAGAATACATATTCATGGCCTTCTAGC...
pathogenic
49,679
Is chromosome 2, position 178598977, gene TTN variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
GATAACCAACTATGATGCTTCTCTTCAATTAGAATACTGAAACCCTTCAAACAGGTTTTTGCATTATTATGATAATTTAGCGATAGGGGTAGAGTCTCATGATGTGAAATGGTCAGCACTGGCAAATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCAGATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCTTCTATGAAAACTATATAACAACATAATAGACACTATGGGGGCAAGTTCTATAAAAAAGCCATATTTATTCTGGGCCATGATTCAGAATACATATTCATGGCCTTCTAGCAATTTGAGA...
GATAACCAACTATGATGCTTCTCTTCAATTAGAATACTGAAACCCTTCAAACAGGTTTTTGCATTATTATGATAATTTAGCGATAGGGGTAGAGTCTCATGATGTGAAATGGTCAGCACTGGCAAATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCAGATTGTTAAACATTCATGTACAGTTTAAGGAAAGTTGCTTCTATGAAAACTATATAACAACATAATAGACACTATGGGGGCAAGTTCTATAAAAAAGCCATATTTATTCTGGGCCATGATTCAGAATACATATTCATGGCCTTCTAGCAATTTGAGA...
pathogenic
49,680
Is the genetic mutation found on chromosome 2 at position 178599194, within the gene TTN, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TAACAACATAATAGACACTATGGGGGCAAGTTCTATAAAAAAGCCATATTTATTCTGGGCCATGATTCAGAATACATATTCATGGCCTTCTAGCAATTTGAGAATTGTGTACATGCACTCTTTAGGTTCACTGGAAACATGGATGCATGTCTTCTTGTTAGCATCTGTTTTCTCAATTATATAATTTGTAAACTTACACCCACCATACAGAATACACATAGAATAAAAAAGTAAGGAGGAAATTTTTAAAAATTCTAATAATGTTCAACATGATTATGGGTGATTTTTCTTATTTTCCAAAATGTTTGTTACACAGCATA...
TAACAACATAATAGACACTATGGGGGCAAGTTCTATAAAAAAGCCATATTTATTCTGGGCCATGATTCAGAATACATATTCATGGCCTTCTAGCAATTTGAGAATTGTGTACATGCACTCTTTAGGTTCACTGGAAACATGGATGCATGTCTTCTTGTTAGCATCTGTTTTCTCAATTATATAATTTGTAAACTTACACCCACCATACAGAATACACATAGAATAAAAAAGTAAGGAGGAAATTTTTAAAAATTCTAATAATGTTCAACATGATTATGGGTGATTTTTCTTATTTTCCAAAATGTTTGTTACACAGCATA...
pathogenic
49,688
Variant on chromosome 2, at position 178599216, affecting TTN: is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GGGGCAAGTTCTATAAAAAAGCCATATTTATTCTGGGCCATGATTCAGAATACATATTCATGGCCTTCTAGCAATTTGAGAATTGTGTACATGCACTCTTTAGGTTCACTGGAAACATGGATGCATGTCTTCTTGTTAGCATCTGTTTTCTCAATTATATAATTTGTAAACTTACACCCACCATACAGAATACACATAGAATAAAAAAGTAAGGAGGAAATTTTTAAAAATTCTAATAATGTTCAACATGATTATGGGTGATTTTTCTTATTTTCCAAAATGTTTGTTACACAGCATACAGCATAGCTTTGTGTAAATAT...
GGGGCAAGTTCTATAAAAAAGCCATATTTATTCTGGGCCATGATTCAGAATACATATTCATGGCCTTCTAGCAATTTGAGAATTGTGTACATGCACTCTTTAGGTTCACTGGAAACATGGATGCATGTCTTCTTGTTAGCATCTGTTTTCTCAATTATATAATTTGTAAACTTACACCCACCATACAGAATACACATAGAATAAAAAAGTAAGGAGGAAATTTTTAAAAATTCTAATAATGTTCAACATGATTATGGGTGATTTTTCTTATTTTCCAAAATGTTTGTTACACAGCATACAGCATAGCTTTGTGTAAATAT...
pathogenic
49,689
Variant in gene TTN, located at chromosome 2 position 178599319: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GTTCACTGGAAACATGGATGCATGTCTTCTTGTTAGCATCTGTTTTCTCAATTATATAATTTGTAAACTTACACCCACCATACAGAATACACATAGAATAAAAAAGTAAGGAGGAAATTTTTAAAAATTCTAATAATGTTCAACATGATTATGGGTGATTTTTCTTATTTTCCAAAATGTTTGTTACACAGCATACAGCATAGCTTTGTGTAAATATAATAAGAATGTTGGTTTAAAAAGTTGCACAGACAAATTGAAAGTATTTACCTAATACATCAACAATAATTGTCTTCTTTCTTTCTCCGGCTTCATTTTTGGCA...
GTTCACTGGAAACATGGATGCATGTCTTCTTGTTAGCATCTGTTTTCTCAATTATATAATTTGTAAACTTACACCCACCATACAGAATACACATAGAATAAAAAAGTAAGGAGGAAATTTTTAAAAATTCTAATAATGTTCAACATGATTATGGGTGATTTTTCTTATTTTCCAAAATGTTTGTTACACAGCATACAGCATAGCTTTGTGTAAATATAATAAGAATGTTGGTTTAAAAAGTTGCACAGACAAATTGAAAGTATTTACCTAATACATCAACAATAATTGTCTTCTTTCTTTCTCCGGCTTCATTTTTGGCA...
pathogenic
49,695
Chromosome 2, position 178599612, gene TTN: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTTCTTTCTCCGGCTTCATTTTTGGCAAGAAGAGAATAGACGCCTTGATGGCTCCTCTGGCAGTTCTTGATGACCATGGATGAGCTAATGGCTGTGGTCTCAATGGTGGCTTCTTGAGGTAAGGTTCTTTCATTCATGTTCCAGGTGACGGTTGGAGGAGGCTTTCCAGACACATAGGCAATGATTCGGATCACCCCTCCAGCATGGACAACAATTCTATCTCTGACACTGGCATCTAGCTGAAGGTCAGGTGAAACTGGAAGCAATTGAAAATTACAAATGTGATTTTTCCCCTTCAATCTGAAACATAAATACTGATG...
TTTCTTTCTCCGGCTTCATTTTTGGCAAGAAGAGAATAGACGCCTTGATGGCTCCTCTGGCAGTTCTTGATGACCATGGATGAGCTAATGGCTGTGGTCTCAATGGTGGCTTCTTGAGGTAAGGTTCTTTCATTCATGTTCCAGGTGACGGTTGGAGGAGGCTTTCCAGACACATAGGCAATGATTCGGATCACCCCTCCAGCATGGACAACAATTCTATCTCTGACACTGGCATCTAGCTGAAGGTCAGGTGAAACTGGAAGCAATTGAAAATTACAAATGTGATTTTTCCCCTTCAATCTGAAACATAAATACTGATG...
pathogenic
49,702
Is the variant located on chromosome 2 at position 178600863, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Tibial_muscular_dystrophy']
TGCATATACCCGGAATTGATAGTCGGAACCTTCAATAAGACCAGTCACTTTATAAGAAACACCCAAAGTCATGGCTTTGATAGGATCTCGGTTAACTCTCTTCCATCTCTTTGAAGTGGTGTCTTTCATTTCCAGCCAGTACCCTGTCACAGGAGAGCCTCCATCATATTCTGGCTCTTCCCAGTTGACAGTCATGGAGTTACGAGTCACGCTGCTAACTGTTGGTTTATCTGGTGCTCCAGGGACAGCTGTGAAAAAGATCATATTGATTATAAGAAATTTAAAAAAAAAGTAAAAATGGCTTTGTATGTGAAAATGTT...
TGCATATACCCGGAATTGATAGTCGGAACCTTCAATAAGACCAGTCACTTTATAAGAAACACCCAAAGTCATGGCTTTGATAGGATCTCGGTTAACTCTCTTCCATCTCTTTGAAGTGGTGTCTTTCATTTCCAGCCAGTACCCTGTCACAGGAGAGCCTCCATCATATTCTGGCTCTTCCCAGTTGACAGTCATGGAGTTACGAGTCACGCTGCTAACTGTTGGTTTATCTGGTGCTCCAGGGACAGCTGTGAAAAAGATCATATTGATTATAAGAAATTTAAAAAAAAAGTAAAAATGGCTTTGTATGTGAAAATGTT...
pathogenic
49,717
Evaluate if the mutation on chromosome 2 at position 178601016 in TTN is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AGAGCCTCCATCATATTCTGGCTCTTCCCAGTTGACAGTCATGGAGTTACGAGTCACGCTGCTAACTGTTGGTTTATCTGGTGCTCCAGGGACAGCTGTGAAAAAGATCATATTGATTATAAGAAATTTAAAAAAAAAGTAAAAATGGCTTTGTATGTGAAAATGTTCTCCTACTTACAGAAGAGGTTTCTTGCTGTTTCAGGTTCACTGTCAAGAGGTTCTCCAATGCCATATTTATTCTGGGCCATGATTCGGAATACATATTCATGGCCTTCTAGCAATTTGGGAATCGTGTACGTGCACTCCTTAGGTTCACTGGA...
AGAGCCTCCATCATATTCTGGCTCTTCCCAGTTGACAGTCATGGAGTTACGAGTCACGCTGCTAACTGTTGGTTTATCTGGTGCTCCAGGGACAGCTGTGAAAAAGATCATATTGATTATAAGAAATTTAAAAAAAAAGTAAAAATGGCTTTGTATGTGAAAATGTTCTCCTACTTACAGAAGAGGTTTCTTGCTGTTTCAGGTTCACTGTCAAGAGGTTCTCCAATGCCATATTTATTCTGGGCCATGATTCGGAATACATATTCATGGCCTTCTAGCAATTTGGGAATCGTGTACGTGCACTCCTTAGGTTCACTGGA...
pathogenic
49,726
Chromosome 2, position 178601454, gene TTN: Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GATTCAAATTTTATGGGTCCCACTGGAGGGCCAGGACGACCTAAAATGGTTTAAAGAAGGAACCCTTTATCACTCAGATGATTTTAAAGCCAAATGTTATTTATGAACAGAAAAACAAGTAATTTTAACCAAACCATGCAGTCTTTACCCAGGACATTCAGTCTCATCTCCTTTGATGCTGTTCCCAGATTATTTACAGCTGTGATGGTATATAAGCCAGTGTCACTCCTGCGAGACTGCGGAATAACTAAAGTGCAAGTATCATCTACCACCAGTTTGTTGACATGGGTGTCATAGAGAACAGGTTCTTTGTTATCAGG...
GATTCAAATTTTATGGGTCCCACTGGAGGGCCAGGACGACCTAAAATGGTTTAAAGAAGGAACCCTTTATCACTCAGATGATTTTAAAGCCAAATGTTATTTATGAACAGAAAAACAAGTAATTTTAACCAAACCATGCAGTCTTTACCCAGGACATTCAGTCTCATCTCCTTTGATGCTGTTCCCAGATTATTTACAGCTGTGATGGTATATAAGCCAGTGTCACTCCTGCGAGACTGCGGAATAACTAAAGTGCAAGTATCATCTACCACCAGTTTGTTGACATGGGTGTCATAGAGAACAGGTTCTTTGTTATCAGG...
pathogenic
49,741
Benign or pathogenic: chromosome 2, position 178601535, gene TTN variant? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TTTTAAAGCCAAATGTTATTTATGAACAGAAAAACAAGTAATTTTAACCAAACCATGCAGTCTTTACCCAGGACATTCAGTCTCATCTCCTTTGATGCTGTTCCCAGATTATTTACAGCTGTGATGGTATATAAGCCAGTGTCACTCCTGCGAGACTGCGGAATAACTAAAGTGCAAGTATCATCTACCACCAGTTTGTTGACATGGGTGTCATAGAGAACAGGTTCTTTGTTATCAGGCTTCTTTGGAGGAGCTTTAAACCAGGTTAGTGTCGGGAATGGCACACCTTTAATTTTGGCCACAATGTTAACATTGGTTCC...
TTTTAAAGCCAAATGTTATTTATGAACAGAAAAACAAGTAATTTTAACCAAACCATGCAGTCTTTACCCAGGACATTCAGTCTCATCTCCTTTGATGCTGTTCCCAGATTATTTACAGCTGTGATGGTATATAAGCCAGTGTCACTCCTGCGAGACTGCGGAATAACTAAAGTGCAAGTATCATCTACCACCAGTTTGTTGACATGGGTGTCATAGAGAACAGGTTCTTTGTTATCAGGCTTCTTTGGAGGAGCTTTAAACCAGGTTAGTGTCGGGAATGGCACACCTTTAATTTTGGCCACAATGTTAACATTGGTTCC...
pathogenic
49,743
Benign or pathogenic: chromosome 2, position 178601664, gene TTN variant? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TATAAGCCAGTGTCACTCCTGCGAGACTGCGGAATAACTAAAGTGCAAGTATCATCTACCACCAGTTTGTTGACATGGGTGTCATAGAGAACAGGTTCTTTGTTATCAGGCTTCTTTGGAGGAGCTTTAAACCAGGTTAGTGTCGGGAATGGCACACCTTTAATTTTGGCCACAATGTTAACATTGGTTCCTTCTTCAACCTCCATGAATTCTTTTAGATCAATTGATGGTGGGCCTAGATTATTTAAAAAAAGTTGTCATTAGGAGCAAAAAGCATTGAGGGATAGAAAGTAGAATTCACAGTTACTATAAAGTTGTTT...
TATAAGCCAGTGTCACTCCTGCGAGACTGCGGAATAACTAAAGTGCAAGTATCATCTACCACCAGTTTGTTGACATGGGTGTCATAGAGAACAGGTTCTTTGTTATCAGGCTTCTTTGGAGGAGCTTTAAACCAGGTTAGTGTCGGGAATGGCACACCTTTAATTTTGGCCACAATGTTAACATTGGTTCCTTCTTCAACCTCCATGAATTCTTTTAGATCAATTGATGGTGGGCCTAGATTATTTAAAAAAAGTTGTCATTAGGAGCAAAAAGCATTGAGGGATAGAAAGTAGAATTCACAGTTACTATAAAGTTGTTT...
pathogenic
49,746
Clinically, how would you classify the variant at chromosome 2, position 178601686, gene TTN: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GAGACTGCGGAATAACTAAAGTGCAAGTATCATCTACCACCAGTTTGTTGACATGGGTGTCATAGAGAACAGGTTCTTTGTTATCAGGCTTCTTTGGAGGAGCTTTAAACCAGGTTAGTGTCGGGAATGGCACACCTTTAATTTTGGCCACAATGTTAACATTGGTTCCTTCTTCAACCTCCATGAATTCTTTTAGATCAATTGATGGTGGGCCTAGATTATTTAAAAAAAGTTGTCATTAGGAGCAAAAAGCATTGAGGGATAGAAAGTAGAATTCACAGTTACTATAAAGTTGTTTGGATCCACTGTAGGCAGACTTT...
GAGACTGCGGAATAACTAAAGTGCAAGTATCATCTACCACCAGTTTGTTGACATGGGTGTCATAGAGAACAGGTTCTTTGTTATCAGGCTTCTTTGGAGGAGCTTTAAACCAGGTTAGTGTCGGGAATGGCACACCTTTAATTTTGGCCACAATGTTAACATTGGTTCCTTCTTCAACCTCCATGAATTCTTTTAGATCAATTGATGGTGGGCCTAGATTATTTAAAAAAAGTTGTCATTAGGAGCAAAAAGCATTGAGGGATAGAAAGTAGAATTCACAGTTACTATAAAGTTGTTTGGATCCACTGTAGGCAGACTTT...
pathogenic
49,749
Gene TTN variant at chromosome position 178602097 on chromosome 2: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
ATCTACATGTGGCTATGTATCTGTGCTTGCCTCACTTTATTTGGCATCATTATGCATGTAATGATGTGTATTATTATATTCTCATATCCTGACAAAAGGGAAGAGAGGAGATTGTAGTAGGAGAGTATCATGGGATACTCTCTTTAATATTTACACAGAATTATGAAGGGATACACAAGAAGGTGAATTCCCCTTTTAAGAAATATAACTGTTAATAAAAGGAAAGCAATTTTCCATTTTGCACAAATTTAGGACAGAAATATTCAAAGAGGGTAGTGACTACAGTTTCTTCACACTTAGATGAGAGAATAAACAAATAC...
ATCTACATGTGGCTATGTATCTGTGCTTGCCTCACTTTATTTGGCATCATTATGCATGTAATGATGTGTATTATTATATTCTCATATCCTGACAAAAGGGAAGAGAGGAGATTGTAGTAGGAGAGTATCATGGGATACTCTCTTTAATATTTACACAGAATTATGAAGGGATACACAAGAAGGTGAATTCCCCTTTTAAGAAATATAACTGTTAATAAAAGGAAAGCAATTTTCCATTTTGCACAAATTTAGGACAGAAATATTCAAAGAGGGTAGTGACTACAGTTTCTTCACACTTAGATGAGAGAATAAACAAATAC...
pathogenic
49,765
Gene TTN variant at chromosome 2, position 178602141—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CATCATTATGCATGTAATGATGTGTATTATTATATTCTCATATCCTGACAAAAGGGAAGAGAGGAGATTGTAGTAGGAGAGTATCATGGGATACTCTCTTTAATATTTACACAGAATTATGAAGGGATACACAAGAAGGTGAATTCCCCTTTTAAGAAATATAACTGTTAATAAAAGGAAAGCAATTTTCCATTTTGCACAAATTTAGGACAGAAATATTCAAAGAGGGTAGTGACTACAGTTTCTTCACACTTAGATGAGAGAATAAACAAATACACAACAGTAGTGATGGTAATTATCAGAGGAAGAATTATTACCAT...
CATCATTATGCATGTAATGATGTGTATTATTATATTCTCATATCCTGACAAAAGGGAAGAGAGGAGATTGTAGTAGGAGAGTATCATGGGATACTCTCTTTAATATTTACACAGAATTATGAAGGGATACACAAGAAGGTGAATTCCCCTTTTAAGAAATATAACTGTTAATAAAAGGAAAGCAATTTTCCATTTTGCACAAATTTAGGACAGAAATATTCAAAGAGGGTAGTGACTACAGTTTCTTCACACTTAGATGAGAGAATAAACAAATACACAACAGTAGTGATGGTAATTATCAGAGGAAGAATTATTACCAT...
pathogenic
49,767
Evaluate this variant at chromosome 2, position 178602402, gene TTN: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AGAATAAACAAATACACAACAGTAGTGATGGTAATTATCAGAGGAAGAATTATTACCATATATATATATATATATATATATATATATACTTCATTAAAATGGATATATCTTTTCTCATATAGAGAAATAAAAACTTGATTGTGAAGATAAATGGGTCTCAGCAGTTGCTAAGAAAATGACTGGTTACTTTCTGTCCCTTTTGAGGAGCATGCAGAGAAATTGCTTTAGCCTCTGATAAATAAAACAGACTGCGAGGAAAATTACAGCGAGGAAATTACAGACATCATCTCCTTTGAACAGGGAAAAGGTAACAGGTAAGG...
AGAATAAACAAATACACAACAGTAGTGATGGTAATTATCAGAGGAAGAATTATTACCATATATATATATATATATATATATATATATACTTCATTAAAATGGATATATCTTTTCTCATATAGAGAAATAAAAACTTGATTGTGAAGATAAATGGGTCTCAGCAGTTGCTAAGAAAATGACTGGTTACTTTCTGTCCCTTTTGAGGAGCATGCAGAGAAATTGCTTTAGCCTCTGATAAATAAAACAGACTGCGAGGAAAATTACAGCGAGGAAATTACAGACATCATCTCCTTTGAACAGGGAAAAGGTAACAGGTAAGG...
pathogenic
49,771
A genetic alteration at chromosome 2, position 178602603, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
GAGGAGCATGCAGAGAAATTGCTTTAGCCTCTGATAAATAAAACAGACTGCGAGGAAAATTACAGCGAGGAAATTACAGACATCATCTCCTTTGAACAGGGAAAAGGTAACAGGTAAGGGAATGTGAAAATTCTGTGGAAATTGAAGGAATGAGTAATTAAGTAATGTGCCCATGTCTACATTCAAGCCATAGTAGCTTCCTAAGGTACAGATATAGCTCTTTTAATTGTGAACTATTATTGAACACCTAGGAAGGCAGCTGTAAGGAGGACATTCTTTGTCAGTACATTGGTACTTACATGTCTGGTCTTTGACAGTCA...
GAGGAGCATGCAGAGAAATTGCTTTAGCCTCTGATAAATAAAACAGACTGCGAGGAAAATTACAGCGAGGAAATTACAGACATCATCTCCTTTGAACAGGGAAAAGGTAACAGGTAAGGGAATGTGAAAATTCTGTGGAAATTGAAGGAATGAGTAATTAAGTAATGTGCCCATGTCTACATTCAAGCCATAGTAGCTTCCTAAGGTACAGATATAGCTCTTTTAATTGTGAACTATTATTGAACACCTAGGAAGGCAGCTGTAAGGAGGACATTCTTTGTCAGTACATTGGTACTTACATGTCTGGTCTTTGACAGTCA...
benign
49,778
The genetic variant at chromosome 2, position 178603877, affecting gene TTN: benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AGCAATATTGAAGTCAACCATATTCTGAATTATTTTAATTATTATTTTTTTACCTGTGCATCTTCGGGTATGTCATGAACTCCATCCTATTAGAAAAGGAGACAGTCAGTTGTAGTATAAATACTCCTTATAGTGATTCAGTGGAAAAAAGAGGAGAATGGTTATTTTCCTACCTTCATTGCTTTCTTTGCCTTTCCATCAAATTCCCAAGATGATTTTGGTGTTGGGCGTCCCTTGATGACAGCAGGAATCCTAATCTGTGAGCCAGCTTTACAAACCAGACAGTCCTGTGCTCCAATGTCAATGAAAACTTCTGGTTC...
AGCAATATTGAAGTCAACCATATTCTGAATTATTTTAATTATTATTTTTTTACCTGTGCATCTTCGGGTATGTCATGAACTCCATCCTATTAGAAAAGGAGACAGTCAGTTGTAGTATAAATACTCCTTATAGTGATTCAGTGGAAAAAAGAGGAGAATGGTTATTTTCCTACCTTCATTGCTTTCTTTGCCTTTCCATCAAATTCCCAAGATGATTTTGGTGTTGGGCGTCCCTTGATGACAGCAGGAATCCTAATCTGTGAGCCAGCTTTACAAACCAGACAGTCCTGTGCTCCAATGTCAATGAAAACTTCTGGTTC...
pathogenic
49,780
Located at chromosome 2 position 178604259, the variant affecting gene TTN—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ATCTTCAGTAAATTAATCAATTTCATAATAAGATCAAAAGAGGAATACATAAACTGAGTAAGTACTAGTACCTTGAATATCAGTGGCAGGGATCTCCCCAGTTGTATCACTTGGTTCAGATTCACCAGCTTCATTGACAGCTTTCACTCTGAATCTGTACTTCCTGAGCTCTTTCAGATTAGGCACCACACATTCACAGGTAGTTATAAGTTTGTCTGGTTCATTTACTCTTTTCCAGTCAGTAGTACCTTCTTCTTGCATTTCTACAATGTATCCTTTGATTGGGCTGCCACCATCTTTGGCTGGAGGTTTCCATCCTA...
ATCTTCAGTAAATTAATCAATTTCATAATAAGATCAAAAGAGGAATACATAAACTGAGTAAGTACTAGTACCTTGAATATCAGTGGCAGGGATCTCCCCAGTTGTATCACTTGGTTCAGATTCACCAGCTTCATTGACAGCTTTCACTCTGAATCTGTACTTCCTGAGCTCTTTCAGATTAGGCACCACACATTCACAGGTAGTTATAAGTTTGTCTGGTTCATTTACTCTTTTCCAGTCAGTAGTACCTTCTTCTTGCATTTCTACAATGTATCCTTTGATTGGGCTGCCACCATCTTTGGCTGGAGGTTTCCATCCTA...
pathogenic
49,794
Considering the genetic mutation at chromosome 2, position 178604293, impacting TTN: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CAAAAGAGGAATACATAAACTGAGTAAGTACTAGTACCTTGAATATCAGTGGCAGGGATCTCCCCAGTTGTATCACTTGGTTCAGATTCACCAGCTTCATTGACAGCTTTCACTCTGAATCTGTACTTCCTGAGCTCTTTCAGATTAGGCACCACACATTCACAGGTAGTTATAAGTTTGTCTGGTTCATTTACTCTTTTCCAGTCAGTAGTACCTTCTTCTTGCATTTCTACAATGTATCCTTTGATTGGGCTGCCACCATCTTTGGCTGGAGGTTTCCATCCTAGTGAGATGCTTGACTTCGTTTTATCTTTAACTTC...
CAAAAGAGGAATACATAAACTGAGTAAGTACTAGTACCTTGAATATCAGTGGCAGGGATCTCCCCAGTTGTATCACTTGGTTCAGATTCACCAGCTTCATTGACAGCTTTCACTCTGAATCTGTACTTCCTGAGCTCTTTCAGATTAGGCACCACACATTCACAGGTAGTTATAAGTTTGTCTGGTTCATTTACTCTTTTCCAGTCAGTAGTACCTTCTTCTTGCATTTCTACAATGTATCCTTTGATTGGGCTGCCACCATCTTTGGCTGGAGGTTTCCATCCTAGTGAGATGCTTGACTTCGTTTTATCTTTAACTTC...
pathogenic
49,796
Clinical significance of chromosome 2, position 178604768, gene TTN: benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TACAGTTGCCTTCTAGAGAAGAGAAATAAAGGAAATGGTCTATTTTCCTTTAGCATTAATGCAAAAACAGAGAAAGCAAACAACTAACTGGGAATAGAAAGACTACTTCCTATCTTGTTAGATTTACATTCTATTTATACATGATTGGTAAAAAACTACTTTACTTTTGAGATCCCTTTGAAGAAATTCTACAATAGCCTTTACTGAAAACATGATTTAAATTTAATTTGCCACAATATGAAAATTTAAAAAGGATTCCATCAATAGCTAGTAAACCTTTGAACACAAACTAATCTTAATGCCCTTTAGGGACAGGATCA...
TACAGTTGCCTTCTAGAGAAGAGAAATAAAGGAAATGGTCTATTTTCCTTTAGCATTAATGCAAAAACAGAGAAAGCAAACAACTAACTGGGAATAGAAAGACTACTTCCTATCTTGTTAGATTTACATTCTATTTATACATGATTGGTAAAAAACTACTTTACTTTTGAGATCCCTTTGAAGAAATTCTACAATAGCCTTTACTGAAAACATGATTTAAATTTAATTTGCCACAATATGAAAATTTAAAAAGGATTCCATCAATAGCTAGTAAACCTTTGAACACAAACTAATCTTAATGCCCTTTAGGGACAGGATCA...
pathogenic
49,805
Variant at chromosome 2, position 178605044, gene TTN: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CTTTGAACACAAACTAATCTTAATGCCCTTTAGGGACAGGATCAGTGTCTACAATAATCCCATAACAATCCTTTACCTTTCTGAAAGTGCTTTACAATTACAGAAATTCTTTTACTGTACTTGTCTTTTTAATCTTAACTTTTCCCCCTCCAGTGGTTAATATAGATCCTTGCACAAAGCACATGTTCAATACTAGTTTGCAAATGAATGAATAACTACCTCATTATATAGGTATATATGCTCCACATAGCACTTGAGTATTTAAAATTTTCTTTTTAACAAATAATTGAATTTTTCTTCTATAGAGAATCTAATCAGAT...
CTTTGAACACAAACTAATCTTAATGCCCTTTAGGGACAGGATCAGTGTCTACAATAATCCCATAACAATCCTTTACCTTTCTGAAAGTGCTTTACAATTACAGAAATTCTTTTACTGTACTTGTCTTTTTAATCTTAACTTTTCCCCCTCCAGTGGTTAATATAGATCCTTGCACAAAGCACATGTTCAATACTAGTTTGCAAATGAATGAATAACTACCTCATTATATAGGTATATATGCTCCACATAGCACTTGAGTATTTAAAATTTTCTTTTTAACAAATAATTGAATTTTTCTTCTATAGAGAATCTAATCAGAT...
pathogenic
49,816
A genetic variant on chromosome 2, position 178605064, affects the gene TTN. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_familial_dilated_cardiomyopathy', 'TTN-related_myopathy']
TAATGCCCTTTAGGGACAGGATCAGTGTCTACAATAATCCCATAACAATCCTTTACCTTTCTGAAAGTGCTTTACAATTACAGAAATTCTTTTACTGTACTTGTCTTTTTAATCTTAACTTTTCCCCCTCCAGTGGTTAATATAGATCCTTGCACAAAGCACATGTTCAATACTAGTTTGCAAATGAATGAATAACTACCTCATTATATAGGTATATATGCTCCACATAGCACTTGAGTATTTAAAATTTTCTTTTTAACAAATAATTGAATTTTTCTTCTATAGAGAATCTAATCAGATATGTAGCAAATAGGATGAAT...
TAATGCCCTTTAGGGACAGGATCAGTGTCTACAATAATCCCATAACAATCCTTTACCTTTCTGAAAGTGCTTTACAATTACAGAAATTCTTTTACTGTACTTGTCTTTTTAATCTTAACTTTTCCCCCTCCAGTGGTTAATATAGATCCTTGCACAAAGCACATGTTCAATACTAGTTTGCAAATGAATGAATAACTACCTCATTATATAGGTATATATGCTCCACATAGCACTTGAGTATTTAAAATTTTCTTTTTAACAAATAATTGAATTTTTCTTCTATAGAGAATCTAATCAGATATGTAGCAAATAGGATGAAT...
pathogenic
49,818