accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q8NGC5 | OR6J1_HUMAN | Olfactory receptor 6J2 | Homo | <M><G><N><W><T><A><A><V><T><E><F><V><L><L><G><F><S><L><S><R><E><V><E><L><L><L><L><V><L><L><L><P><T><F><L><L><T><L><L><G><N><L><L><I><I><S><T><V><L><S><C><S><R><L><H><T><P><M><Y><F><F><L><C><N><L><S><I><L><D><I><L><F><T><S><V><I><S><P><K><V><L><A><N><L><G><S><R><D><K><T><I><S><F><A><G><C><I><T><Q><C><Y><F><Y><F><F><L><G><T><V><E><F><L><L><L><T><V><M><S><Y><D><R><Y><A><T><I><C><C><P><L><R><Y><T><T><I><M><R><P><S><V><C><I><G><T><V><V><F><S><W><V><G><G><F><L><S><V><L><F><P><T><I><L><I><S><Q><L><P><F><C><G><S><N><I><I><N><H><F><F><C><D><S><G><P><L><L><A><L><A><C><A><D><T><T><A><I><E><L><M><D><F><M><L><S><S><M><V><I><L><C><C><I><V><L><V><A><Y><S><Y><T><Y><I><I><L><T><I><V><R><I><P><S><A><S><G><R><K><K><A><F><N><T><C><A><S><H><L><T><I><V><I><I><P><S><G><I><T><V><F><I><Y><V><T><P><S><Q><K><E><Y><L><E><I><N><K><I><P><L><V><L><S><S><V><V><T><P><F><L><N><P><F><I><Y><T><L><R><N><D><T><V><Q><G><V><L><R><D><V><W><V><R><V><R><G><V><F><E><K><R><M><R><A><V><L><R><S><R><L><S><S><N><K><D><H><Q><G><R><A><C><S><S><P><P><C><V><Y><S><V><K><L><Q><C> | Odorant receptor.<BOP> | Q8NGC5 |
Q9NYW0 | T2R10_HUMAN | Taste receptor family B member 2 | Homo | <M><L><R><V><V><E><G><I><F><I><F><V><V><V><S><E><S><V><F><G><V><L><G><N><G><F><I><G><L><V><N><C><I><D><C><A><K><N><K><L><S><T><I><G><F><I><L><T><G><L><A><I><S><R><I><F><L><I><W><I><I><I><T><D><G><F><I><Q><I><F><S><P><N><I><Y><A><S><G><N><L><I><E><Y><I><S><Y><F><W><V><I><G><N><Q><S><S><M><W><F><A><T><S><L><S><I><F><Y><F><L><K><I><A><N><F><S><N><Y><I><F><L><W><L><K><S><R><T><N><M><V><L><P><F><M><I><V><F><L><L><I><S><S><L><L><N><F><A><Y><I><A><K><I><L><N><D><Y><K><T><K><N><D><T><V><W><D><L><N><M><Y><K><S><E><Y><F><I><K><Q><I><L><L><N><L><G><V><I><F><F><F><T><L><S><L><I><T><C><I><F><L><I><I><S><L><W><R><H><N><R><Q><M><Q><S><N><V><T><G><L><R><D><S><N><T><E><A><H><V><K><A><M><K><V><L><I><S><F><I><I><L><F><I><L><Y><F><I><G><M><A><I><E><I><S><C><F><T><V><R><E><N><K><L><L><L><M><F><G><M><T><T><T><A><I><Y><P><W><G><H><S><F><I><L><I><L><G><N><S><K><L><K><Q><A><S><L><R><V><L><Q><Q><L><K><C><C><E><K><R><K><N><L><R><V><T> | Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.<BOP> | Q9NYW0 |
O43913 | ORC5_HUMAN | Origin recognition complex subunit 5 | Homo | <M><P><H><L><E><N><V><V><L><C><R><E><S><Q><V><S><I><L><Q><S><L><F><G><E><R><H><H><F><S><F><P><S><I><F><I><Y><G><H><T><A><S><G><K><T><Y><V><T><Q><T><L><L><K><T><L><E><L><P><H><V><F><V><N><C><V><E><C><F><T><L><R><L><L><L><E><Q><I><L><N><K><L><N><H><L><S><S><S><E><D><G><C><S><T><E><I><T><C><E><T><F><N><D><F><V><R><L><F><K><Q><V><T><T><A><E><N><L><K><D><Q><T><V><Y><I><V><L><D><K><A><E><Y><L><R><D><M><E><A><N><L><L><P><G><F><L><R><L><Q><E><L><A><D><R><N><V><T><V><L><F><L><S><E><I><V><W><E><K><F><R><P><N><T><G><C><F><E><P><F><V><L><Y><F><P><D><Y><S><I><G><N><L><Q><K><I><L><S><H><D><H><P><P><E><Y><S><A><D><F><Y><A><A><Y><I><N><I><L><L><G><V><F><Y><T><V><C><R><D><L><K><E><L><R><H><L><A><V><L><N><F><P><K><Y><C><E><P><V><V><K><G><E><A><S><E><R><D><T><R><K><L><W><R><N><I><E><P><H><L><K><K><A><M><Q><T><V><Y><L><R><E><I><S><S><S><Q><W><E><K><L><Q><K><D><D><T><D><P><G><Q><L><K><G><L><S><A><H><T><H><V><E><L><P><Y><Y><S><K><F><I><L><I><A><A><Y><L><A><S><Y><N><P><A><R><T><D><K><R><F><F><L><K><H><H><G><K><I><K><K><T><N><F><L><K><K><H><E><K><T><S><N><H><L><L><G><P><K><P><F><P><L><D><R><L><L><A><I><L><Y><S><I><V><D><S><R><V><A><P><T><A><N><I><F><S><Q><I><T><S><L><V><T><L><Q><L><L><T><L><V><G><H><D><D><Q><L><D><G><P><K><Y><K><C><T><V><S><L><D><F><I><R><A><I><A><R><T><V><N><F><D><I><I><K><Y><L><Y><D><F><L> | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.<BOP> | O43913 |
Q6L8G9 | KRA56_HUMAN | Ultrahigh sulfur keratin-associated protein 5.6 | Homo | <M><G><C><C><G><C><S><G><G><C><G><S><G><C><G><G><C><G><S><G><C><G><G><C><G><S><S><C><C><V><P><I><C><C><C><K><P><V><C><C><C><V><P><A><C><S><C><T><S><C><G><S><C><G><G><S><K><G><C><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><C><S><Q><C><S><C><C><K><P><C><Y><C><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><C><C><S><Q><A><S><C><C><V><P><I><C><C><Q><C><K><I> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q6L8G9 |
Q14714 | SSPN_HUMAN | Kirsten-ras-associated protein | Homo | <M><G><K><N><K><Q><P><R><G><Q><Q><R><Q><G><G><P><P><A><A><D><A><A><G><P><D><D><M><E><P><K><K><G><T><G><A><P><K><E><C><G><E><E><E><P><R><T><C><C><G><C><R><F><P><L><L><L><A><L><L><Q><L><A><L><G><I><A><V><T><V><V><G><F><L><M><A><S><I><S><S><S><L><L><V><R><D><T><P><F><W><A><G><I><I><V><C><L><V><A><Y><L><G><L><F><M><L><C><V><S><Y><Q><V><D><E><R><T><C><I><Q><F><S><M><K><L><L><Y><F><L><L><S><A><L><G><L><T><V><C><V><L><A><V><A><F><A><A><H><H><Y><S><Q><L><T><Q><F><T><C><E><T><T><L><D><S><C><Q><C><K><L><P><S><S><E><P><L><S><R><T><F><V><Y><R><D><V><T><D><C><T><S><V><T><G><T><F><K><L><F><L><L><I><Q><M><I><L><N><L><V><C><G><L><V><C><L><L><A><C><F><V><M><W><K><H><R><Y><Q><V><F><Y><V><G><V><R><I><C><S><L><T><A><S><E><G><P><Q><Q><K><I> | Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.<BOP> | Q14714 |
Q96DS6 | M4A6E_HUMAN | Membrane-spanning 4-domains subfamily A member 6E | Homo | <M><T><S><Q><P><I><S><N><E><T><I><I><M><L><P><S><N><V><I><N><F><S><Q><A><E><K><P><E><P><T><N><Q><G><Q><D><S><L><K><K><R><L><Q><A><K><V><K><V><I><G><V><H><S><S><L><A><G><S><I><L><S><A><L><S><A><L><V><G><F><I><L><L><S><V><N><P><A><A><L><N><P><A><S><L><Q><C><K><L><D><E><K><D><I><P><T><R><L><L><L><S><Y><D><Y><H><S><P><Y><T><M><D><C><H><R><A><K><A><S><L><A><G><T><L><S><L><M><L><V><S><T><V><L><E><F><C><L><A><V><L><T><A><V><L><Q><W><K><Q><T><V> | May be involved in signal transduction as a component of a multimeric receptor complex.<BOP> | Q96DS6 |
A0A584 | TVBK2_HUMAN | T cell receptor beta variable 11-2 | Homo | <M><G><T><R><L><L><C><W><A><A><L><C><L><L><G><A><E><L><T><E><A><G><V><A><Q><S><P><R><Y><K><I><I><E><K><R><Q><S><V><A><F><W><C><N><P><I><S><G><H><A><T><L><Y><W><Y><Q><Q><I><L><G><Q><G><P><K><L><L><I><Q><F><Q><N><N><G><V><V><D><D><S><Q><L><P><K><D><R><F><S><A><E><R><L><K><G><V><D><S><T><L><K><I><Q><P><A><K><L><E><D><S><A><V><Y><L><C><A><S><S><L> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A584 |
P01112 | RASH_HUMAN | GTPase HRas, N-terminally processed | Homo | <M><T><E><Y><K><L><V><V><V><G><A><G><G><V><G><K><S><A><L><T><I><Q><L><I><Q><N><H><F><V><D><E><Y><D><P><T><I><E><D><S><Y><R><K><Q><V><V><I><D><G><E><T><C><L><L><D><I><L><D><T><A><G><Q><E><E><Y><S><A><M><R><D><Q><Y><M><R><T><G><E><G><F><L><C><V><F><A><I><N><N><T><K><S><F><E><D><I><H><Q><Y><R><E><Q><I><K><R><V><K><D><S><D><D><V><P><M><V><L><V><G><N><K><C><D><L><A><A><R><T><V><E><S><R><Q><A><Q><D><L><A><R><S><Y><G><I><P><Y><I><E><T><S><A><K><T><R><Q><G><V><E><D><A><F><Y><T><L><V><R><E><I><R><Q><H><K><L><R><K><L><N><P><P><D><E><S><G><P><G><C><M><S><C><K><C><V><L><S> | Involved in the activation of Ras protein signal transduction . Ras proteins bind GDP/GTP and possess intrinsic GTPase activity .<BOP> | P01112 |
Q9Y3B6 | EMC9_HUMAN | Protein FAM158A | Homo | <M><G><E><V><E><I><S><A><L><A><Y><V><K><M><C><L><H><A><A><R><Y><P><H><A><A><V><N><G><L><F><L><A><P><A><P><R><S><G><E><C><L><C><L><T><D><C><V><P><L><F><H><S><H><L><A><L><S><V><M><L><E><V><A><L><N><Q><V><D><V><W><G><A><Q><A><G><L><V><V><A><G><Y><Y><H><A><N><A><A><V><N><D><Q><S><P><G><P><L><A><L><K><I><A><G><R><I><A><E><F><F><P><D><A><V><L><I><M><L><D><N><Q><K><L><V><P><Q><P><R><V><P><P><V><I><V><L><E><N><Q><G><L><R><W><V><P><K><D><K><N><L><V><M><W><R><D><W><E><E><S><R><Q><M><V><G><A><L><L><E><D><R><A><H><Q><H><L><V><D><F><D><C><H><L><D><D><I><R><Q><D><W><T><N><Q><R><L><N><T><Q><I><T><Q><W><V><G><P><T><N><G><N><G><N><A> | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).<BOP> | Q9Y3B6 |
Q96JJ3 | ELMO2_HUMAN | Protein ced-12 homolog A | Homo | <M><P><P><P><S><D><I><V><K><V><A><I><E><W><P><G><A><N><A><Q><L><L><E><I><D><Q><K><R><P><L><A><S><I><I><K><E><V><C><D><G><W><S><L><P><N><P><E><Y><Y><T><L><R><Y><A><D><G><P><Q><L><Y><I><T><E><Q><T><R><S><D><I><K><N><G><T><I><L><Q><L><A><I><S><P><S><R><A><A><R><Q><L><M><E><R><T><Q><S><S><N><M><E><T><R><L><D><A><M><K><E><L><A><K><L><S><A><D><V><T><F><A><T><E><F><I><N><M><D><G><I><I><V><L><T><R><L><V><E><S><G><T><K><L><L><S><H><Y><S><E><M><L><A><F><T><L><T><A><F><L><E><L><M><D><H><G><I><V><S><W><D><M><V><S><I><T><F><I><K><Q><I><A><G><Y><V><S><Q><P><M><V><D><V><S><I><L><Q><R><S><L><A><I><L><E><S><M><V><L><N><S><Q><S><L><Y><Q><K><I><A><E><E><I><T><V><G><Q><L><I><S><H><L><Q><V><S><N><Q><E><I><Q><T><Y><A><I><A><L><I><N><A><L><F><L><K><A><P><E><D><K><R><Q><D><M><A><N><A><F><A><Q><K><H><L><R><S><I><I><L><N><H><V><I><R><G><N><R><P><I><K><T><E><M><A><H><Q><L><Y><V><L><Q><V><L><T><F><N><L><L><E><E><R><M><M><T><K><M><D><P><N><D><Q><A><Q><R><D><I><I><F><E><L><R><R><I><A><F><D><A><E><S><D><P><S><N><A><P><G><S><G><T><E><K><R><K><A><M><Y><T><K><D><Y><K><M><L><G><F><T><N><H><I><N><P><A><M><D><F><T><Q><T><P><P><G><M><L><A><L><D><N><M><L><Y><L><A><K><V><H><Q><D><T><Y><I><R><I><V><L><E><N><S><S><R><E><D><K><H><E><C><P><F><G><R><S><A><I><E><L><T><K><M><L><C><E><I><L><Q><V><G><E><L><P><N><E><G><R><N><D><Y><H><P><M><F><F><T><H><D><R><A><F><E><E><L><F><G><I><C><I><Q><L><L><N><K><T><W><K><E><M><R><A><T><A><E><D><F><N><K><V><M><Q><V><V><R><E><Q><I><T><R><A><L><P><S><K><P><N><S><L><D><Q><F><K><S><K><L><R><S><L><S><Y><S><E><I><L><R><L><R><Q><S><E><R><M><S><Q><D><D><F><Q><S><P><P><I><V><E><L><R><E><K><I><Q><P><E><I><L><E><L><I><K><Q><Q><R><L><N><R><L><C><E><G><S><S><F><R><K><I><G><N><R><R><R><Q><E><R><F><W><Y><C><R><L><A><L><N><H><K><V><L><H><Y><G><D><L><D><D><N><P><Q><G><E><V><T><F><E><S><L><Q><E><K><I><P><V><A><D><I><K><A><I><V><T><G><K><D><C><P><H><M><K><E><K><S><A><L><K><Q><N><K><E><V><L><E><L><A><F><S><I><L><Y><D><P><D><E><T><L><N><F><I><A><P><N><K><Y><E><Y><C><I><W><I><D><G><L><S><A><L><L><G><K><D><M><S><S><E><L><T><K><S><D><L><D><T><L><L><S><M><E><M><K><L><R><L><L><D><L><E><N><I><Q><I><P><E><A><P><P><P><I><P><K><E><P><S><S><Y><D><F><V><Y><H><Y><G> | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.<BOP> | Q96JJ3 |
Q96BZ9 | TBC20_HUMAN | TBC1 domain family member 20 | Homo | <M><A><L><R><S><A><Q><G><D><G><P><T><S><G><H><W><D><G><G><A><E><K><A><D><F><N><A><K><R><K><K><K><V><A><E><I><H><Q><A><L><N><S><D><P><T><D><V><A><A><L><R><R><M><A><I><S><E><G><G><L><L><T><D><E><I><R><R><K><V><W><P><K><L><L><N><V><N><A><N><D><P><P><P><I><S><G><K><N><L><R><Q><M><S><K><D><Y><Q><Q><V><L><L><D><V><R><R><S><L><R><R><F><P><P><G><M><P><E><E><Q><R><E><G><L><Q><E><E><L><I><D><I><I><L><L><I><L><E><R><N><P><Q><L><H><Y><Y><Q><G><Y><H><D><I><V><V><T><F><L><L><V><V><G><E><R><L><A><T><S><L><V><E><K><L><S><T><H><H><L><R><D><F><M><D><P><T><M><D><N><T><K><H><I><L><N><Y><L><M><P><I><I><D><Q><V><N><P><E><L><H><D><F><M><Q><S><A><E><V><G><T><I><F><A><L><S><W><L><I><T><W><F><G><H><V><L><S><D><F><R><H><V><V><R><L><Y><D><F><F><L><A><C><H><P><L><M><P><I><Y><F><A><A><V><I><V><L><Y><R><E><Q><E><V><L><D><C><D><C><D><M><A><S><V><H><H><L><L><S><Q><I><P><Q><D><L><P><Y><E><T><L><I><S><R><A><G><D><L><F><V><Q><F><P><P><S><E><L><A><R><E><A><A><A><Q><Q><Q><A><E><R><T><A><A><S><T><F><K><D><F><E><L><A><S><A><Q><Q><R><P><D><M><V><L><R><Q><R><F><R><G><L><L><R><P><E><D><R><T><K><D><V><L><T><K><P><R><T><N><R><F><V><K><L><A><V><M><G><L><T><V><A><L><G><A><A><A><L><A><V><V><K><S><A><L><E><W><A><P><K><F><Q><L><Q><L><F><P> | GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.<BOP> | Q96BZ9 |
O95456 | PSMG1_HUMAN | Down syndrome critical region protein 2 | Homo | <M><A><A><T><F><F><G><E><V><V><K><A><P><C><R><A><G><T><E><D><E><E><E><E><E><E><G><R><R><E><T><P><E><D><R><E><V><R><L><Q><L><A><R><K><R><E><V><R><L><L><R><R><Q><T><K><T><S><L><E><V><S><L><L><E><K><Y><P><C><S><K><F><I><I><A><I><G><N><N><A><V><A><F><L><S><S><F><V><M><N><S><G><V><W><E><E><V><G><C><A><K><L><W><N><E><W><C><R><T><T><D><T><T><H><L><S><S><T><E><A><F><C><V><F><Y><H><L><K><S><N><P><S><V><F><L><C><Q><C><S><C><Y><V><A><E><D><Q><Q><Y><Q><W><L><E><K><V><F><G><S><C><P><R><K><N><M><Q><I><T><I><L><T><C><R><H><V><T><D><Y><K><T><S><E><S><T><G><S><L><P><S><P><F><L><R><A><L><K><T><Q><N><F><K><D><S><A><C><C><P><L><L><E><Q><P><N><I><V><H><D><L><P><A><A><V><L><S><Y><C><Q><V><W><K><I><P><A><I><L><Y><L><C><Y><T><D><V><M><K><L><D><L><I><T><V><E><A><F><K><P><I><L><S><T><R><S><L><K><G><L><V><K><N><I><P><Q><S><T><E><I><L><K><K><L><M><T><T><N><E><I><Q><S><N><I><Y><T> | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.<BOP> | O95456 |
Q13526 | PIN1_HUMAN | Rotamase Pin1 | Homo | <M><A><D><E><E><K><L><P><P><G><W><E><K><R><M><S><R><S><S><G><R><V><Y><Y><F><N><H><I><T><N><A><S><Q><W><E><R><P><S><G><N><S><S><S><G><G><K><N><G><Q><G><E><P><A><R><V><R><C><S><H><L><L><V><K><H><S><Q><S><R><R><P><S><S><W><R><Q><E><K><I><T><R><T><K><E><E><A><L><E><L><I><N><G><Y><I><Q><K><I><K><S><G><E><E><D><F><E><S><L><A><S><Q><F><S><D><C><S><S><A><K><A><R><G><D><L><G><A><F><S><R><G><Q><M><Q><K><P><F><E><D><A><S><F><A><L><R><T><G><E><M><S><G><P><V><F><T><D><S><G><I><H><I><I><L><R><T><E> | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs . By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes . Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK . Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation . Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner . Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN . May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 | Q13526 |
O43172 | PRP4_HUMAN | WD splicing factor Prp4 | Homo | <M><A><S><S><R><A><S><S><T><Q><A><T><K><T><K><A><P><D><D><L><V><A><P><V><V><K><K><P><H><I><Y><Y><G><S><L><E><E><K><E><R><E><R><L><A><K><G><E><S><G><I><L><G><K><D><G><L><K><A><G><I><E><A><G><N><I><N><I><T><S><G><E><V><F><E><I><E><E><H><I><S><E><R><Q><A><E><V><L><A><E><F><E><R><R><K><R><A><R><Q><I><N><V><S><T><D><D><S><E><V><K><A><C><L><R><A><L><G><E><P><I><T><L><F><G><E><G><P><A><E><R><R><E><R><L><R><N><I><L><S><V><V><G><T><D><A><L><K><K><T><K><K><D><D><E><K><S><K><K><S><K><E><E><Y><Q><Q><T><W><Y><H><E><G><P><N><S><L><K><V><A><R><L><W><I><A><N><Y><S><L><P><R><A><M><K><R><L><E><E><A><R><L><H><K><E><I><P><E><T><T><R><T><S><Q><M><Q><E><L><H><K><S><L><R><S><L><N><N><F><C><S><Q><I><G><D><D><R><P><I><S><Y><C><H><F><S><P><N><S><K><M><L><A><T><A><C><W><S><G><L><C><K><L><W><S><V><P><D><C><N><L><L><H><T><L><R><G><H><N><T><N><V><G><A><I><V><F><H><P><K><S><T><V><S><L><D><P><K><D><V><N><L><A><S><C><A><A><D><G><S><V><K><L><W><S><L><D><S><D><E><P><V><A><D><I><E><G><H><T><V><R><V><A><R><V><M><W><H><P><S><G><R><F><L><G><T><T><C><Y><D><R><S><W><R><L><W><D><L><E><A><Q><E><E><I><L><H><Q><E><G><H><S><M><G><V><Y><D><I><A><F><H><Q><D><G><S><L><A><G><T><G><G><L><D><A><F><G><R><V><W><D><L><R><T><G><R><C><I><M><F><L><E><G><H><L><K><E><I><Y><G><I><N><F><S><P><N><G><Y><H><I><A><T><G><S><G><D><N><T><C><K><V><W><D><L><R><Q><R><R><C><V><Y><T><I><P><A><H><Q><N><L><V><T><G><V><K><F><E><P><I><H><G><N><F><L><L><T><G><A><Y><D><N><T><A><K><I><W><T><H><P><G><W><S><P><L><K><T><L><A><G><H><E><G><K><V><M><G><L><D><I><S><S><D><G><Q><L><I><A><T><C><S><Y><D><R><T><F><K><L><W><M><A><E> | Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).<BOP> | O43172 |
Q96M61 | MAGBI_HUMAN | MAGE-B18 antigen | Homo | <M><P><R><G><Q><K><S><K><L><R><A><R><E><K><R><H><Q><A><R><C><E><N><Q><D><L><G><A><T><Q><A><T><V><A><E><G><E><S><P><S><P><A><Y><L><L><F><G><D><R><P><Q><N><L><P><A><A><E><T><P><S><I><P><E><A><L><Q><G><A><P><S><T><T><N><A><I><A><P><V><S><C><S><S><N><E><G><A><S><S><Q><D><E><K><S><L><G><S><S><R><E><A><E><G><W><K><E><D><P><L><N><K><K><V><V><S><L><V><H><F><L><L><Q><K><Y><E><T><K><E><P><I><T><K><G><D><M><I><K><F><V><I><R><K><D><K><C><H><F><N><E><I><L><K><R><A><S><E><H><M><E><L><A><L><G><V><D><L><K><E><V><D><P><I><R><H><Y><Y><A><F><F><S><K><L><D><L><T><Y><D><E><T><T><S><D><E><E><K><I><P><K><T><G><L><L><M><I><A><L><G><V><I><F><L><N><G><N><R><A><P><E><E><A><V><W><E><I><M><N><M><M><G><V><Y><A><D><R><K><H><F><L><Y><G><D><P><R><K><V><M><T><K><D><L><V><Q><L><K><Y><L><E><Y><Q><Q><V><P><N><S><D><P><P><R><Y><E><F><L><W><G><P><R><A><H><A><E><T><S><K><M><K><V><L><E><F><V><A><K><I><H><D><T><V><P><S><A><F><P><S><C><Y><E><E><A><L><R><D><E><E><Q><R><T><Q><A><R><A><A><A><R><A><H><T><A><A><M><A><N><A><R><S><R><T><T><S><S><S><F><S><H><A><K> | May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.<BOP> | Q96M61 |
Q9NP77 | SSU72_HUMAN | RNA polymerase II subunit A C-terminal domain phosphatase SSU72 | Homo | <M><P><S><S><P><L><R><V><A><V><V><C><S><S><N><Q><N><R><S><M><E><A><H><N><I><L><S><K><R><G><F><S><V><R><S><F><G><T><G><T><H><V><K><L><P><G><P><A><P><D><K><P><N><V><Y><D><F><K><T><T><Y><D><Q><M><Y><N><D><L><L><R><K><D><K><E><L><Y><T><Q><N><G><I><L><H><M><L><D><R><N><K><R><I><K><P><R><P><E><R><F><Q><N><C><K><D><L><F><D><L><I><L><T><C><E><E><R><V><Y><D><Q><V><V><E><D><L><N><S><R><E><Q><E><T><C><Q><P><V><H><V><V><N><V><D><I><Q><D><N><H><E><E><A><T><L><G><A><F><L><I><C><E><L><C><Q><C><I><Q><H><T><E><D><M><E><N><E><I><D><E><L><L><Q><E><F><E><E><K><S><G><R><T><F><L><H><T><V><C><F><Y> | Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.<BOP> | Q9NP77 |
Q8NHW4 | CC4L_HUMAN | Small-inducible cytokine A4-like | Homo | <M><K><L><C><V><T><V><L><S><L><L><V><L><V><A><A><F><C><S><L><A><L><S><A><P><M><G><S><D><P><P><T><A><C><C><F><S><Y><T><A><R><K><L><P><R><N><F><V><V><D><Y><Y><E><T><S><S><L><C><S><Q><P><A><V><V><F><Q><T><K><R><G><K><Q><V><C><A><D><P><S><E><S><W><V><Q><E><Y><V><Y><D><L><E><L><N> | Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.<BOP> | Q8NHW4 |
Q13253 | NOGG_HUMAN | Noggin | Homo | <M><E><R><C><P><S><L><G><V><T><L><Y><A><L><V><V><V><L><G><L><R><A><T><P><A><G><G><Q><H><Y><L><H><I><R><P><A><P><S><D><N><L><P><L><V><D><L><I><E><H><P><D><P><I><F><D><P><K><E><K><D><L><N><E><T><L><L><R><S><L><L><G><G><H><Y><D><P><G><F><M><A><T><S><P><P><E><D><R><P><G><G><G><G><G><A><A><G><G><A><E><D><L><A><E><L><D><Q><L><L><R><Q><R><P><S><G><A><M><P><S><E><I><K><G><L><E><F><S><E><G><L><A><Q><G><K><K><Q><R><L><S><K><K><L><R><R><K><L><Q><M><W><L><W><S><Q><T><F><C><P><V><L><Y><A><W><N><D><L><G><S><R><F><W><P><R><Y><V><K><V><G><S><C><F><S><K><R><S><C><S><V><P><E><G><M><V><C><K><P><S><K><S><V><H><L><T><V><L><R><W><R><C><Q><R><R><G><G><Q><R><C><G><W><I><P><I><Q><Y><P><I><I><S><E><C><K><C><S><C> | Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 .<BOP> | Q13253 |
Q8NES8 | DB124_HUMAN | Defensin, beta 124 | Homo | <M><T><Q><L><L><L><F><L><V><A><L><L><V><L><G><H><V><P><S><G><R><S><E><F><K><R><C><W><K><G><Q><G><A><C><Q><T><Y><C><T><R><Q><E><T><Y><M><H><L><C><P><D><A><S><L><C><C><L><S><Y><A><L><K><P><P><P><V><P><K><H><E><Y><E> | Has antibacterial activity.<BOP> | Q8NES8 |
Q96CM8 | ACSF2_HUMAN | Medium-chain acyl-CoA ligase ACSF2, mitochondrial | Homo | <M><A><V><Y><V><G><M><L><R><L><G><R><L><C><A><G><S><S><G><V><L><G><A><R><A><A><L><S><R><S><W><Q><E><A><R><L><Q><G><V><R><F><L><S><S><R><E><V><D><R><M><V><S><T><P><I><G><G><L><S><Y><V><Q><G><C><T><K><K><H><L><N><S><K><T><V><G><Q><C><L><E><T><T><A><Q><R><V><P><E><R><E><A><L><V><V><L><H><E><D><V><R><L><T><F><A><Q><L><K><E><E><V><D><K><A><A><S><G><L><L><S><I><G><L><C><K><G><D><R><L><G><M><W><G><P><N><S><Y><A><W><V><L><M><Q><L><A><T><A><Q><A><G><I><I><L><V><S><V><N><P><A><Y><Q><A><M><E><L><E><Y><V><L><K><K><V><G><C><K><A><L><V><F><P><K><Q><F><K><T><Q><Q><Y><Y><N><V><L><K><Q><I><C><P><E><V><E><N><A><Q><P><G><A><L><K><S><Q><R><L><P><D><L><T><T><V><I><S><V><D><A><P><L><P><G><T><L><L><L><D><E><V><V><A><A><G><S><T><R><Q><H><L><D><Q><L><Q><Y><N><Q><Q><F><L><S><C><H><D><P><I><N><I><Q><F><T><S><G><T><T><G><S><P><K><G><A><T><L><S><H><Y><N><I><V><N><N><S><N><I><L><G><E><R><L><K><L><H><E><K><T><P><E><Q><L><R><M><I><L><P><N><P><L><Y><H><C><L><G><S><V><A><G><T><M><M><C><L><M><Y><G><A><T><L><I><L><A><S><P><I><F><N><G><K><K><A><L><E><A><I><S><R><E><R><G><T><F><L><Y><G><T><P><T><M><F><V><D><I><L><N><Q><P><D><F><S><S><Y><D><I><S><T><M><C><G><G><V><I><A><G><S><P><A><P><P><E><L><I><R><A><I><I><N><K><I><N><M><K><D><L><V><V><A><Y><G><T><T><E><N><S><P><V><T><F><A><H><F><P><E><D><T><V><E><Q><K><A><E><S><V><G><R><I><M><P><H><T><E><A><R><I><M><N><M><E><A><G><T><L><A><K><L><N><T><P><G><E><L><C><I><R><G><Y><C><V><M><L><G><Y><W><G><E><P><Q><K><T><E><E><A><V><D><Q><D><K><W><Y><W><T><G><D><V><A><T><M><N><E><Q><G><F><C><K><I><V><G><R><S><K><D><M><I><I><R><G><G><E><N><I><Y><P><A><E><L><E><D><F><F><H><T><H><P><K><V><Q><E><V><Q><V><V><G><V><K><D><D><R><M><G><E><E><I><C><A><C><I><R><L><K><D><G><E><E><T><T><V><E><E><I><K><A><F><C><K><G><K><I><S><H><F><K><I><P><K><Y><I><V><F><V><T><N><Y><P><L><T><I><S><G><K><I><Q><K><F><K><L><R><E><Q><M><E><R><H><L><N><L> | Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA . Has some preference toward medium-chain substrates . Plays a role in adipocyte differentiation .<BOP> | Q96CM8 |
Q969N4 | TAAR8_HUMAN | Trace amine receptor 5 | Homo | <M><T><S><N><F><S><Q><P><V><V><Q><L><C><Y><E><D><V><N><G><S><C><I><E><T><P><Y><S><P><G><S><R><V><I><L><Y><T><A><F><S><F><G><S><L><L><A><V><F><G><N><L><L><V><M><T><S><V><L><H><F><K><Q><L><H><S><P><T><N><F><L><I><A><S><L><A><C><A><D><F><L><V><G><V><T><V><M><L><F><S><M><V><R><T><V><E><S><C><W><Y><F><G><A><K><F><C><T><L><H><S><C><C><D><V><A><F><C><Y><S><S><V><L><H><L><C><F><I><C><I><D><R><Y><I><V><V><T><D><P><L><V><Y><A><T><K><F><T><V><S><V><S><G><I><C><I><S><V><S><W><I><L><P><L><T><Y><S><G><A><V><F><Y><T><G><V><N><D><D><G><L><E><E><L><V><S><A><L><N><C><V><G><G><C><Q><I><I><V><S><Q><G><W><V><L><I><D><F><L><L><F><F><I><P><T><L><V><M><I><I><L><Y><S><K><I><F><L><I><A><K><Q><Q><A><I><K><I><E><T><T><S><S><K><V><E><S><S><S><E><S><Y><K><I><R><V><A><K><R><E><R><K><A><A><K><T><L><G><V><T><V><L><A><F><V><I><S><W><L><P><Y><T><V><D><I><L><I><D><A><F><M><G><F><L><T><P><A><Y><I><Y><E><I><C><C><W><S><A><Y><Y><N><S><A><M><N><P><L><I><Y><A><L><F><Y><P><W><F><R><K><A><I><K><L><I><L><S><G><D><V><L><K><A><S><S><S><T><I><S><L><F><L><E> | Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.<BOP> | Q969N4 |
Q96T51 | RUFY1_HUMAN | Zinc finger FYVE domain-containing protein 12 | Homo | <M><A><D><R><E><G><G><C><A><A><G><R><G><R><E><L><E><P><E><L><E><P><G><P><G><P><G><S><A><L><E><P><G><E><E><F><E><I><V><D><R><S><Q><L><P><G><P><G><D><L><R><S><A><T><R><P><R><A><A><E><G><W><S><A><P><I><L><T><L><A><R><R><A><T><G><N><L><S><A><S><C><G><S><A><L><R><A><A><A><G><L><G><G><G><D><S><G><D><G><T><A><R><A><A><S><K><C><Q><M><M><E><E><R><A><N><L><M><H><M><M><K><L><S><I><K><V><L><L><Q><S><A><L><S><L><G><R><S><L><D><A><D><H><A><P><L><Q><Q><F><F><V><V><M><E><H><C><L><K><H><G><L><K><V><K><K><S><F><I><G><Q><N><K><S><F><F><G><P><L><E><L><V><E><K><L><C><P><E><A><S><D><I><A><T><S><V><R><N><L><P><E><L><K><T><A><V><G><R><G><R><A><W><L><Y><L><A><L><M><Q><K><K><L><A><D><Y><L><K><V><L><I><D><N><K><H><L><L><S><E><F><Y><E><P><E><A><L><M><M><E><E><E><G><M><V><I><V><G><L><L><V><G><L><N><V><L><D><A><N><L><C><L><K><G><E><D><L><D><S><Q><V><G><V><I><D><F><S><L><Y><L><K><D><V><Q><D><L><D><G><G><K><E><H><E><R><I><T><D><V><L><D><Q><K><N><Y><V><E><E><L><N><R><H><L><S><C><T><V><G><D><L><Q><T><K><I><D><G><L><E><K><T><N><S><K><L><Q><E><E><L><S><A><A><T><D><R><I><C><S><L><Q><E><E><Q><Q><Q><L><R><E><Q><N><E><L><I><R><E><R><S><E><K><S><V><E><I><T><K><Q><D><T><K><V><E><L><E><T><Y><K><Q><T><R><Q><G><L><D><E><M><Y><S><D><V><W><K><Q><L><K><E><E><K><K><V><R><L><E><L><E><K><E><L><E><L><Q><I><G><M><K><T><E><M><E><I><A><M><K><L><L><E><K><D><T><H><E><K><Q><D><T><L><V><A><L><R><Q><Q><L><E><E><V><K><A><I><N><L><Q><M><F><H><K><A><Q><N><A><E><S><S><L><Q><Q><K><N><E><A><I><T><S><F><E><G><K><T><N><Q><V><M><S><S><M><K><Q><M><E><E><R><L><Q><H><S><E><R><A><R><Q><G><A><E><E><R><S><H><K><L><Q><Q><E><L><G><G><R><I><G><A><L><Q><L><Q><L><S><Q><L><H><E><Q><C><S><S><L><E><K><E><L><K><S><E><K><E><Q><R><Q><A><L><Q><R><E><L><Q><H><E><K><D><T><S><S><L><L><R><M><E><L><Q><Q><V><E><G><L><K><K><E><L><R><E><L><Q><D><E><K><A><E><L><Q><K><I><C><E><E><Q><E><Q><A><L><Q><E><M><G><L><H><L><S><Q><S><K><L><K><M><E><D><I><K><E><V><N><Q><A><L><K><G><H><A><W><L><K><D><D><E><A><T><H><C><R><Q><C><E><K><E><F><S><I><S><R><R><K><H><H><C><R><N><C><G><H><I><F><C><N><T><C><S><S><N><E><L><A><L><P><S><Y><P><K><P><V><R><V><C><D><S><C><H><T><L><L><L><Q><R><C><S><S><T><A><S> | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.<BOP> | Q96T51 |
O60519 | CRBL2_HUMAN | cAMP-responsive element-binding protein-like 2 | Homo | <M><D><D><S><K><V><V><G><G><K><V><K><K><P><G><K><R><G><R><K><P><A><K><I><D><L><K><A><K><L><E><R><S><R><Q><S><A><R><E><C><R><A><R><K><K><L><R><Y><Q><Y><L><E><E><L><V><S><S><R><E><R><A><I><C><A><L><R><E><E><L><E><M><Y><K><Q><W><C><M><A><M><D><Q><G><K><I><P><S><E><I><K><A><L><L><T><G><E><E><Q><N><K><S><Q><Q><N><S><S><R><H><T><K><A><G><K><T><D><A><N><S><N><S><W> | Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.<BOP> | O60519 |
Q03936 | ZNF92_HUMAN | Zinc finger protein HTF12 | Homo | <M><G><P><L><T><F><R><D><V><K><I><E><F><S><L><E><E><W><Q><C><L><D><T><A><Q><R><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><F><L><G><I><A><V><S><K><P><D><L><I><T><W><L><E><Q><G><K><E><P><W><N><L><K><R><H><E><M><V><D><K><T><P><V><M><C><S><H><F><A><Q><D><V><W><P><E><H><S><I><K><D><S><F><Q><K><V><I><L><R><T><Y><G><K><Y><G><H><E><N><L><Q><L><R><K><D><H><K><S><V><D><A><C><K><V><Y><K><G><G><Y><N><G><L><N><Q><C><L><T><T><T><D><S><K><I><F><Q><C><D><K><Y><V><K><V><F><H><K><F><P><N><V><N><R><N><K><I><R><H><T><G><K><K><P><F><K><C><K><N><R><G><K><S><F><C><M><L><S><Q><L><T><Q><H><K><K><I><H><T><R><E><Y><S><Y><K><C><E><E><C><G><K><A><F><N><W><S><S><T><L><T><K><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><N><L><T><K><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><T><L><T><K><H><K><R><I><H><T><E><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><F><S><I><L><N><K><H><K><R><I><H><M><E><D><K><P><Y><K><C><E><E><C><G><K><A><F><R><V><F><S><I><L><K><K><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><F><S><N><L><T><K><H><K><I><I><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><A><F><N><Q><S><S><T><L><T><K><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><Q><S><S><T><L><T><E><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><K><C><G><K><A><F><S><W><S><S><A><F><T><K><H><K><R><N><H><M><E><D><K><P><Y><K><C><E><E><C><G><K><A><F><S><V><F><S><T><L><T><K><H><K><I><I><H><T><R><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><I><F><T><K><H><K><I><I><H><T><E><G><K><S><Y><K><C><E><K><C><G><N><A><F><N><Q><S><S><N><L><T><A><R><K><I><I><Y><T><G><E><K><P><Y><K><Y><E><E><C><D><K><A><F><N><K><F><S><T><L><I><T><H><Q><I><I><Y><T><G><E><K><P><C><K><H><E><C><G><R><A><F><N><K><S><S><N><Y><T><K><E><K><L><Q><T> | May be involved in transcriptional regulation.<BOP> | Q03936 |
Q12972 | PP1R8_HUMAN | ARD-1 | Homo | <M><A><A><A><A><N><S><G><S><S><L><P><L><F><D><C><P><T><W><A><G><K><P><P><P><G><L><H><L><D><V><V><K><G><D><K><L><I><E><K><L><I><I><D><E><K><K><Y><Y><L><F><G><R><N><P><D><L><C><D><F><T><I><D><H><Q><S><C><S><R><V><H><A><A><L><V><Y><H><K><H><L><K><R><V><F><L><I><D><L><N><S><T><H><G><T><F><L><G><H><I><R><L><E><P><H><K><P><Q><Q><I><P><I><D><S><T><V><S><F><G><A><S><T><R><A><Y><T><L><R><E><K><P><Q><T><L><P><S><A><V><K><G><D><E><K><M><G><G><E><D><D><E><L><K><G><L><L><G><L><P><E><E><E><T><E><L><D><N><L><T><E><F><N><T><A><H><N><K><R><I><S><T><L><T><I><E><E><G><N><L><D><I><Q><R><P><K><R><K><R><K><N><S><R><V><T><F><S><E><D><D><E><I><I><N><P><E><D><V><D><P><S><V><G><R><F><R><N><M><V><Q><T><A><V><V><P><V><K><K><K><R><V><E><G><P><G><S><L><G><L><E><E><S><G><S><R><R><M><Q><N><F><A><F><S><G><G><L><Y><G><G><L><P><P><T><H><S><E><A><G><S><Q><P><H><G><I><H><G><T><A><L><I><G><G><L><P><M><P><Y><P><N><L><A><P><D><V><D><L><T><P><V><V><P><S><A><V><N><M><N><P><A><P><N><P><A><V><Y><N><P><E><A><V><N><E><P><K><K><K><K><Y><A><K><E><A><W><P><G><K><K><P><T><P><S><L><L><I> | Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.<BOP> | Q12972 |
Q6UWZ7 | ABRX1_HUMAN | null | Homo | <M><E><G><E><S><T><S><A><V><L><S><G><F><V><L><G><A><L><A><F><Q><H><L><N><T><D><S><D><T><E><G><F><L><L><G><E><V><K><G><E><A><K><N><S><I><T><D><S><Q><M><D><D><V><E><V><V><Y><T><I><D><I><Q><K><Y><I><P><C><Y><Q><L><F><S><F><Y><N><S><S><G><E><V><N><E><Q><A><L><K><K><I><L><S><N><V><K><K><N><V><V><G><W><Y><K><F><R><R><H><S><D><Q><I><M><T><F><R><E><R><L><L><H><K><N><L><Q><E><H><F><S><N><Q><D><L><V><F><L><L><L><T><P><S><I><I><T><E><S><C><S><T><H><R><L><E><H><S><L><Y><K><P><Q><K><G><L><F><H><R><V><P><L><V><V><A><N><L><G><M><S><E><Q><L><G><Y><K><T><V><S><G><S><C><M><S><T><G><F><S><R><A><V><Q><T><H><S><S><K><F><F><E><E><D><G><S><L><K><E><V><H><K><I><N><E><M><Y><A><S><L><Q><E><E><L><K><S><I><C><K><K><V><E><D><S><E><Q><A><V><D><K><L><V><K><D><V><N><R><L><K><R><E><I><E><K><R><R><G><A><Q><I><Q><A><A><R><E><K><N><I><Q><K><D><P><Q><E><N><I><F><L><C><Q><A><L><R><T><F><F><P><N><S><E><F><L><H><S><C><V><M><S><L><K><N><R><H><V><S><K><S><S><C><N><Y><N><H><H><L><D><V><V><D><N><L><T><L><M><V><E><H><T><D><I><P><E><A><S><P><A><S><T><P><Q><I><I><K><H><K><A><L><D><L><D><D><R><W><Q><F><K><R><S><R><L><L><D><T><Q><D><K><R><S><K><A><D><T><G><S><S><N><Q><D><K><A><S><K><M><S><S><P><E><T><D><E><E><I><E><K><M><K><G><F><G><E><Y><S><R><S><P><T><F> | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.<BOP> | Q6UWZ7 |
Q3B7J2 | GFOD2_HUMAN | Glucose-fructose oxidoreductase domain-containing protein 2 | Homo | <M><K><M><L><P><G><V><G><V><F><G><T><G><S><S><A><R><V><L><V><P><L><L><R><A><E><G><F><T><V><E><A><L><W><G><K><T><E><E><E><A><K><Q><L><A><E><E><M><N><I><A><F><Y><T><S><R><T><D><D><I><L><L><H><Q><D><V><D><L><V><C><I><S><I><P><P><P><L><T><R><Q><I><S><V><K><A><L><G><I><G><K><N><V><V><C><E><K><A><A><T><S><V><D><A><F><R><M><V><T><A><S><R><Y><Y><P><Q><L><M><S><L><V><G><N><V><L><R><F><L><P><A><F><V><R><M><K><Q><L><I><S><E><H><Y><V><G><A><V><M><I><C><D><A><R><I><Y><S><G><S><L><L><S><P><S><Y><G><W><I><C><D><E><L><M><G><G><G><G><L><H><T><M><G><T><Y><I><V><D><L><L><T><H><L><T><G><R><R><A><E><K><V><H><G><L><L><K><T><F><V><R><Q><N><A><A><I><R><G><I><R><H><V><T><S><D><D><F><C><F><F><Q><M><L><M><G><G><G><V><C><S><T><V><T><L><N><F><N><M><P><G><A><F><V><H><E><V><M><V><V><G><S><A><G><R><L><V><A><R><G><A><D><L><Y><G><Q><K><N><S><A><T><Q><E><E><L><L><L><R><D><S><L><A><V><G><A><G><L><P><E><Q><G><P><Q><D><V><P><L><L><Y><L><K><G><M><V><Y><M><V><Q><A><L><R><Q><S><F><Q><G><Q><G><D><R><R><T><W><D><R><T><P><V><S><M><A><A><S><F><E><D><G><L><Y><M><Q><S><V><V><D><A><I><K><R><S><S><R><S><G><E><W><E><A><V><E><V><L><T><E><E><P><D><T><N><Q><N><L><C><E><A><L><Q><R><N><N><L> | Promotes matrix assembly.<BOP> | Q3B7J2 |
A6NC51 | T150B_HUMAN | Transmembrane protein 224 | Homo | <M><W><G><Y><L><S><L><M><P><V><F><L><A><V><W><A><I><S><G><V><W><I><V><F><A><I><A><V><T><N><R><T><V><D><L><S><K><G><F><P><Y><I><S><I><C><G><S><F><P><P><Q><S><C><I><F><S><Q><V><L><N><M><G><A><A><L><A><A><W><I><C><I><V><R><Y><H><Q><L><R><D><W><G><V><R><R><W><P><N><Q><L><I><L><W><T><G><L><L><C><A><L><G><T><S><V><V><G><N><F><Q><E><K><N><Q><R><P><T><H><L><A><G><A><F><L><A><F><I><L><G><N><V><Y><F><W><L><Q><L><L><L><W><R><L><K><R><L><P><Q><P><G><A><A><W><I><G><P><L><R><L><G><L><C><S><V><C><T><I><L><I><V><A><M><I><V><L><H><A><C><S><L><R><S><V><S><A><A><C><E><W><V><V><A><M><L><L><F><A><L><F><G><L><L><A><V><D><F><S><A><L><E><S><C><T><L><C><V><Q><P><W><P><S><L><S><P><P><P><A><S><P><I><S><L><P><V><Q><L> | Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux . Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner . May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival .<BOP> | A6NC51 |
O60675 | MAFK_HUMAN | Erythroid transcription factor NF-E2 p18 subunit | Homo | <M><T><T><N><P><K><P><N><K><A><L><K><V><K><K><E><A><G><E><N><A><P><V><L><S><D><D><E><L><V><S><M><S><V><R><E><L><N><Q><H><L><R><G><L><T><K><E><E><V><T><R><L><K><Q><R><R><R><T><L><K><N><R><G><Y><A><A><S><C><R><I><K><R><V><T><Q><K><E><E><L><E><R><Q><R><V><E><L><Q><Q><E><V><E><K><L><A><R><E><N><S><S><M><R><L><E><L><D><A><L><R><S><K><Y><E><A><L><Q><T><F><A><R><T><V><A><R><G><P><V><A><P><S><K><V><A><T><T><S><V><I><T><I><V><K><S><T><E><L><S><S><T><S><V><P><F><S><A><A><S> | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves . However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites . Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor .<BOP> | O60675 |
Q96B33 | CLD23_HUMAN | Claudin-23 | Homo | <M><R><T><P><V><V><M><T><L><G><M><V><L><A><P><C><G><L><L><L><N><L><T><G><T><L><A><P><G><W><R><L><V><K><G><F><L><N><Q><P><V><D><V><E><L><Y><Q><G><L><W><D><M><C><R><E><Q><S><S><R><E><R><E><C><G><Q><T><D><Q><W><G><Y><F><E><A><Q><P><V><L><V><A><R><A><L><M><V><T><S><L><A><A><T><V><L><G><L><L><L><A><S><L><G><V><R><C><W><Q><D><E><P><N><F><V><L><A><G><L><S><G><V><V><L><F><V><A><G><L><L><G><L><I><P><V><S><W><Y><N><H><F><L><G><D><R><D><V><L><P><A><P><A><S><P><V><T><V><Q><V><S><Y><S><L><V><L><G><Y><L><G><S><C><L><L><L><L><G><G><F><S><L><A><L><S><F><A><P><W><C><D><E><R><C><R><R><R><R><K><G><P><S><A><G><P><R><R><S><S><V><S><T><I><Q><V><E><W><P><E><P><D><L><A><P><A><I><K><Y><Y><S><D><G><Q><H><R><P><P><P><A><Q><H><R><K><P><K><P><K><P><K><V><G><F><P><M><P><R><P><R><P><K><A><Y><T><N><S><V><D><V><L><D><G><E><G><W><E><S><Q><D><A><P><S><C><S><T><H><P><C><D><S><S><L><P><C><D><S><D><L> | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP> | Q96B33 |
Q6P9A2 | GLT18_HUMAN | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4 | Homo | <M><V><C><T><R><K><T><K><T><L><V><S><T><C><V><I><L><S><G><M><T><N><I><I><C><L><L><Y><V><G><W><V><T><N><Y><I><A><S><V><Y><V><R><G><Q><E><P><A><P><D><K><K><L><E><E><D><K><G><D><T><L><K><I><I><E><R><L><D><H><L><E><N><V><I><K><Q><H><I><Q><E><A><P><A><K><P><E><E><A><E><A><E><P><F><T><D><S><S><L><F><A><H><W><G><Q><E><L><S><P><E><G><R><R><V><A><L><K><Q><F><Q><Y><Y><G><Y><N><A><Y><L><S><D><R><L><P><L><D><R><P><L><P><D><L><R><P><S><G><C><R><N><L><S><F><P><D><S><L><P><E><V><S><I><V><F><I><F><V><N><E><A><L><S><V><L><L><R><S><I><H><S><A><M><E><R><T><P><P><H><L><L><K><E><I><I><L><V><D><D><N><S><S><N><E><E><L><K><E><K><L><T><E><Y><V><D><K><V><N><S><Q><K><P><G><F><I><K><V><V><R><H><S><K><Q><E><G><L><I><R><S><R><V><S><G><W><R><A><A><T><A><P><V><V><A><L><F><D><A><H><V><E><F><N><V><G><W><A><E><P><V><L><T><R><I><K><E><N><R><K><R><I><I><S><P><S><F><D><N><I><K><Y><D><N><F><E><I><E><E><Y><P><L><A><A><Q><G><F><D><W><E><L><W><C><R><Y><L><N><P><P><K><A><W><W><K><L><E><N><S><T><A><P><I><R><S><P><A><L><I><G><C><F><I><V><D><R><Q><Y><F><Q><E><I><G><L><L><D><E><G><M><E><V><Y><G><G><E><N><V><E><L><G><I><R><V><W><Q><C><G><G><S><V><E><V><L><P><C><S><R><I><A><H><I><E><R><A><H><K><P><Y><T><E><D><L><T><A><H><V><R><R><N><A><L><R><V><A><E><V><W><M><D><E><F><K><S><H><V><Y><M><A><W><N><I><P><Q><E><D><S><G><I><D><I><G><D><I><T><A><R><K><A><L><R><K><Q><L><Q><C><K><T><F><R><W><Y><L><V><S><V><Y><P><E><M><R><M><Y><S><D><I><I><A><Y><G><V><L><Q><N><S><L><K><T><D><L><C><L><D><Q><G><P><D><T><E><N><V><P><I><M><Y><I><C><H><G><M><T><P><Q><N><V><Y><Y><T><S><S><Q><Q><I><H><V><G><I><L><S><P><T><V><D><D><D><D><N><R><C><L><V><D><V><N><S><R><P><R><L><I><E><C><S><Y><A><K><A><K><R><M><K><L><H><W><Q><F><S><Q><G><G><P><I><Q><N><R><K><S><K><R><C><L><E><L><Q><E><N><S><D><L><E><F><G><F><Q><L><V><L><Q><K><C><S><G><Q><H><W><S><I><T><N><V><L><R><S><L><A><S> | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor.<BOP> | Q6P9A2 |
Q9BX79 | STRA6_HUMAN | Stimulated by retinoic acid gene 6 protein homolog | Homo | <M><S><S><Q><P><A><G><N><Q><T><S><P><G><A><T><E><D><Y><S><Y><G><S><W><Y><I><D><E><P><Q><G><G><E><E><L><Q><P><E><G><E><V><P><S><C><H><T><S><I><P><P><G><L><Y><H><A><C><L><A><S><L><S><I><L><V><L><L><L><L><A><M><L><V><R><R><R><Q><L><W><P><D><C><V><R><G><R><P><G><L><P><S><P><V><D><F><L><A><G><D><R><P><R><A><V><P><A><A><V><F><M><V><L><L><S><S><L><C><L><L><L><P><D><E><D><A><L><P><F><L><T><L><A><S><A><P><S><Q><D><G><K><T><E><A><P><R><G><A><W><K><I><L><G><L><F><Y><Y><A><A><L><Y><Y><P><L><A><A><C><A><T><A><G><H><T><A><A><H><L><L><G><S><T><L><S><W><A><H><L><G><V><Q><V><W><Q><R><A><E><C><P><Q><V><P><K><I><Y><K><Y><Y><S><L><L><A><S><L><P><L><L><L><G><L><G><F><L><S><L><W><Y><P><V><Q><L><V><R><S><F><S><R><R><T><G><A><G><S><K><G><L><Q><S><S><Y><S><E><E><Y><L><R><N><L><L><C><R><K><K><L><G><S><S><Y><H><T><S><K><H><G><F><L><S><W><A><R><V><C><L><R><H><C><I><Y><T><P><Q><P><G><F><H><L><P><L><K><L><V><L><S><A><T><L><T><G><T><A><I><Y><Q><V><A><L><L><L><L><V><G><V><V><P><T><I><Q><K><V><R><A><G><V><T><T><D><V><S><Y><L><L><A><G><F><G><I><V><L><S><E><D><K><Q><E><V><V><E><L><V><K><H><H><L><W><A><L><E><V><C><Y><I><S><A><L><V><L><S><C><L><L><T><F><L><V><L><M><R><S><L><V><T><H><R><T><N><L><R><A><L><H><R><G><A><A><L><D><L><S><P><L><H><R><S><P><H><P><S><R><Q><A><I><F><C><W><M><S><F><S><A><Y><Q><T><A><F><I><C><L><G><L><L><V><Q><Q><I><I><F><F><L><G><T><T><A><L><A><F><L><V><L><M><P><V><L><H><G><R><N><L><L><L><F><R><S><L><E><S><S><W><P><F><W><L><T><L><A><L><A><V><I><L><Q><N><M><A><A><H><W><V><F><L><E><T><H><D><G><H><P><Q><L><T><N><R><R><V><L><Y><A><A><T><F><L><L><F><P><L><N><V><L><V><G><A><M><V><A><T><W><R><V><L><L><S><A><L><Y><N><A><I><H><L><G><Q><M><D><L><S><L><L><P><P><R><A><A><T><L><D><P><G><Y><Y><T><Y><R><N><F><L><K><I><E><V><S><Q><S><H><P><A><M><T><A><F><C><S><L><L><L><Q><A><Q><S><L><L><P><R><T><M><A><A><P><Q><D><S><L><R><P><G><E><E><D><E><G><M><Q><L><L><Q><T><K><D><S><M><A><K><G><A><R><P><G><A><S><R><G><R><A><R><W><G><L><A><Y><T><L><L><H><N><P><T><L><Q><V><F><R><K><T><A><L><L><G><A><N><G><A><Q><P> | Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 . Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A . Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin . Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid . STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid .<BOP> | Q9BX79 |
Q13087 | PDIA2_HUMAN | Pancreas-specific protein disulfide isomerase | Homo | <M><S><R><Q><L><L><P><V><L><L><L><L><L><L><R><A><S><C><P><W><G><Q><E><Q><G><A><R><S><P><S><E><E><P><P><E><E><E><I><P><K><E><D><G><I><L><V><L><S><R><H><T><L><G><L><A><L><R><E><H><P><A><L><L><V><E><F><Y><A><P><W><C><G><H><C><Q><A><L><A><P><E><Y><S><K><A><A><A><V><L><A><A><E><S><M><V><V><T><L><A><K><V><D><G><P><A><Q><R><E><L><A><E><E><F><G><V><T><E><Y><P><T><L><K><F><F><R><N><G><N><R><T><H><P><E><E><Y><T><G><P><R><D><A><E><G><I><A><E><W><L><R><R><R><V><G><P><S><A><M><R><L><E><D><E><A><A><A><Q><A><L><I><G><G><R><D><L><V><V><I><G><F><F><Q><D><L><Q><D><E><D><V><A><T><F><L><A><L><A><Q><D><A><L><D><M><T><F><G><L><T><D><R><P><R><L><F><Q><Q><F><G><L><T><K><D><T><V><V><L><F><K><K><F><D><E><G><R><A><D><F><P><V><D><E><E><L><G><L><D><L><G><D><L><S><R><F><L><V><T><H><S><M><R><L><V><T><E><F><N><S><Q><T><S><A><K><I><F><A><A><R><I><L><N><H><L><L><L><F><V><N><Q><T><L><A><A><H><R><E><L><L><A><G><F><G><E><A><A><P><R><F><R><G><Q><V><L><F><V><V><V><D><V><A><A><D><N><E><H><V><L><Q><Y><F><G><L><K><A><E><A><A><P><T><L><R><L><V><N><L><E><T><T><K><K><Y><A><P><V><D><G><G><P><V><T><A><A><S><I><T><A><F><C><H><A><V><L><N><G><Q><V><K><P><Y><L><L><S><Q><E><I><P><P><D><W><D><Q><R><P><V><K><T><L><V><G><K><N><F><E><Q><V><A><F><D><E><T><K><N><V><F><V><K><F><Y><A><P><W><C><T><H><C><K><E><M><A><P><A><W><E><A><L><A><E><K><Y><Q><D><H><E><D><I><I><I><A><E><L><D><A><T><A><N><E><L><D><A><F><A><V><H><G><F><P><T><L><K><Y><F><P><A><G><P><G><R><K><V><I><E><Y><K><S><T><R><D><L><E><T><F><S><K><F><L><D><N><G><G><V><L><P><T><E><E><P><P><E><E><P><A><A><P><F><P><E><P><P><A><N><S><T><M><G><S><K><E><E><L> | Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.<BOP> | Q13087 |
Q9UEE9 | CFDP1_HUMAN | Bucentaur | Homo | <M><E><E><F><D><S><E><D><F><S><T><S><E><E><D><E><D><Y><V><P><S><G><G><E><Y><S><E><D><D><V><N><E><L><V><K><E><D><E><V><D><G><E><E><Q><T><Q><K><T><Q><G><K><K><R><K><A><Q><S><I><P><A><R><K><R><R><Q><G><G><L><S><L><E><E><E><E><E><E><D><A><N><S><E><S><E><G><S><S><S><E><E><E><D><D><A><A><E><Q><E><K><G><I><G><S><E><D><A><R><K><K><K><E><D><E><L><W><A><S><F><L><N><D><V><G><P><K><S><K><V><P><P><S><T><Q><V><K><K><G><E><E><T><E><E><T><S><S><S><K><L><L><V><K><A><E><E><L><E><K><P><K><E><T><E><K><V><K><I><T><K><V><F><D><F><A><G><E><E><V><R><V><T><K><E><V><D><A><T><S><K><E><A><K><S><F><F><K><Q><N><E><K><E><K><P><Q><A><N><V><P><S><A><L><P><S><L><P><A><G><S><G><L><K><R><S><S><G><M><S><S><L><L><G><K><I><G><A><K><K><Q><K><M><S><T><L><E><K><S><K><L><D><W><E><S><F><K><E><E><E><G><I><G><E><E><L><A><I><H><N><R><G><K><E><G><Y><I><E><R><K><A><F><L><D><R><V><D><H><R><Q><F><E><I><E><R><D><L><R><L><S><K><M><K><P> | May play a role during embryogenesis.<BOP> | Q9UEE9 |
Q9ULI2 | RIMKB_HUMAN | Ribosomal protein S6 modification-like protein B | Homo | <M><C><S><S><V><A><A><K><L><W><F><L><T><D><R><R><I><R><E><D><Y><P><Q><K><E><I><L><R><A><L><K><A><K><C><C><E><E><E><L><D><F><R><A><V><V><M><D><E><V><V><L><T><I><E><Q><G><N><L><G><L><R><I><N><G><E><L><I><T><A><Y><P><Q><V><V><V><V><R><V><P><T><P><W><V><Q><S><D><S><D><I><T><V><L><R><H><L><E><K><M><G><C><R><L><M><N><R><P><Q><A><I><L><N><C><V><N><K><F><W><T><F><Q><E><L><A><G><H><G><V><P><L><P><D><T><F><S><Y><G><G><H><E><N><F><A><K><M><I><D><E><A><E><V><L><E><F><P><M><V><V><K><N><T><R><G><H><R><G><K><A><V><F><L><A><R><D><K><H><H><L><A><D><L><S><H><L><I><R><H><E><A><P><Y><L><F><Q><K><Y><V><K><E><S><H><G><R><D><V><R><V><I><V><V><G><G><R><V><V><G><T><M><L><R><C><S><T><D><G><R><M><Q><S><N><C><S><L><G><G><V><G><M><M><C><S><L><S><E><Q><G><K><Q><L><A><I><Q><V><S><N><I><L><G><M><D><V><C><G><I><D><L><L><M><K><D><D><G><S><F><C><V><C><E><A><N><A><N><V><G><F><I><A><F><D><K><A><C><N><L><D><V><A><G><I><I><A><D><Y><A><A><S><L><L><P><S><G><R><L><T><R><R><M><S><L><L><S><V><V><S><T><A><S><E><T><S><E><P><E><L><G><P><P><A><S><T><A><V><D><N><M><S><A><S><S><S><S><V><D><S><D><P><E><S><T><E><R><E><L><L><T><K><L><P><G><G><L><F><N><M><N><Q><L><L><A><N><E><I><K><L><L><V><D> | Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate.<BOP> | Q9ULI2 |
P30153 | 2AAA_HUMAN | PP2A subunit A isoform R1-alpha | Homo | <M><A><A><A><D><G><D><D><S><L><Y><P><I><A><V><L><I><D><E><L><R><N><E><D><V><Q><L><R><L><N><S><I><K><K><L><S><T><I><A><L><A><L><G><V><E><R><T><R><S><E><L><L><P><F><L><T><D><T><I><Y><D><E><D><E><V><L><L><A><L><A><E><Q><L><G><T><F><T><T><L><V><G><G><P><E><Y><V><H><C><L><L><P><P><L><E><S><L><A><T><V><E><E><T><V><V><R><D><K><A><V><E><S><L><R><A><I><S><H><E><H><S><P><S><D><L><E><A><H><F><V><P><L><V><K><R><L><A><G><G><D><W><F><T><S><R><T><S><A><C><G><L><F><S><V><C><Y><P><R><V><S><S><A><V><K><A><E><L><R><Q><Y><F><R><N><L><C><S><D><D><T><P><M><V><R><R><A><A><A><S><K><L><G><E><F><A><K><V><L><E><L><D><N><V><K><S><E><I><I><P><M><F><S><N><L><A><S><D><E><Q><D><S><V><R><L><L><A><V><E><A><C><V><N><I><A><Q><L><L><P><Q><E><D><L><E><A><L><V><M><P><T><L><R><Q><A><A><E><D><K><S><W><R><V><R><Y><M><V><A><D><K><F><T><E><L><Q><K><A><V><G><P><E><I><T><K><T><D><L><V><P><A><F><Q><N><L><M><K><D><C><E><A><E><V><R><A><A><A><S><H><K><V><K><E><F><C><E><N><L><S><A><D><C><R><E><N><V><I><M><S><Q><I><L><P><C><I><K><E><L><V><S><D><A><N><Q><H><V><K><S><A><L><A><S><V><I><M><G><L><S><P><I><L><G><K><D><N><T><I><E><H><L><L><P><L><F><L><A><Q><L><K><D><E><C><P><E><V><R><L><N><I><I><S><N><L><D><C><V><N><E><V><I><G><I><R><Q><L><S><Q><S><L><L><P><A><I><V><E><L><A><E><D><A><K><W><R><V><R><L><A><I><I><E><Y><M><P><L><L><A><G><Q><L><G><V><E><F><F><D><E><K><L><N><S><L><C><M><A><W><L><V><D><H><V><Y><A><I><R><E><A><A><T><S><N><L><K><K><L><V><E><K><F><G><K><E><W><A><H><A><T><I><I><P><K><V><L><A><M><S><G><D><P><N><Y><L><H><R><M><T><T><L><F><C><I><N><V><L><S><E><V><C><G><Q><D><I><T><T><K><H><M><L><P><T><V><L><R><M><A><G><D><P><V><A><N><V><R><F><N><V><A><K><S><L><Q><K><I><G><P><I><L><D><N><S><T><L><Q><S><E><V><K><P><I><L><E><K><L><T><Q><D><Q><D><V><D><V><K><Y><F><A><Q><E><A><L><T><V><L><S><L><A> | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT . Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis .<BOP> | P30153 |
Q9P1T7 | MDFIC_HUMAN | I-mfa domain-containing protein | Homo | <M><S><G><A><G><E><A><L><A><P><G><P><V><G><P><Q><R><V><A><E><A><G><G><G><Q><L><G><S><T><A><Q><G><K><C><D><K><D><N><T><E><K><D><I><T><Q><A><T><N><S><H><F><T><H><G><E><M><Q><D><Q><S><I><W><G><N><P><S><D><G><E><L><I><R><T><Q><P><Q><R><L><P><Q><L><Q><T><S><A><Q><V><P><S><G><E><E><I><G><K><I><K><N><G><H><T><G><L><S><N><G><N><G><I><H><H><G><A><K><H><G><S><A><D><N><R><K><L><S><A><P><V><S><Q><K><M><H><R><K><I><Q><S><S><L><S><V><N><S><D><I><S><K><K><S><K><V><N><A><V><F><S><Q><K><T><G><S><S><P><E><D><C><C><V><H><C><I><L><A><C><L><F><C><E><F><L><T><L><C><N><I><V><L><G><Q><A><S><C><G><I><C><T><S><E><A><C><C><C><C><C><G><D><E><M><G><D><D><C><N><C><P><C><D><M><D><C><G><I><M><D><A><C><C><E><S><S><D><C><L><E><I><C><M><E><C><C><G><I><C><F><P><S> | Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.<BOP> | Q9P1T7 |
Q9NZM6 | PK2L2_HUMAN | Polycystin-L2 | Homo | <M><A><E><A><S><R><W><H><R><G><G><A><S><K><H><K><L><H><Y><R><K><E><V><E><I><T><T><T><L><Q><E><L><L><L><Y><F><I><F><L><I><N><L><C><I><L><T><F><G><M><V><N><P><H><M><Y><Y><L><N><K><V><M><S><S><L><F><L><D><T><S><V><P><G><E><E><R><T><N><F><K><S><I><R><S><I><T><D><F><W><K><F><M><E><G><P><L><L><E><G><L><Y><W><D><S><W><Y><N><N><Q><Q><L><Y><N><L><K><N><S><S><R><I><Y><Y><E><N><I><L><L><G><V><P><R><V><R><Q><L><K><V><R><N><N><T><C><K><V><Y><S><S><F><Q><S><L><M><S><E><C><Y><G><K><Y><T><S><A><N><E><D><L><S><N><F><G><L><Q><I><N><T><E><W><R><Y><S><T><S><N><T><N><S><P><W><H><W><G><F><L><G><V><Y><R><N><G><G><Y><I><F><T><L><S><K><S><K><S><E><T><K><N><K><F><I><D><L><R><L><N><S><W><I><T><R><G><T><R><V><I><F><I><D><F><S><L><Y><N><A><N><V><N><L><F><C><I><I><R><L><V><A><E><F><P><A><T><G><G><I><L><T><S><W><Q><F><Y><S><V><K><L><L><R><Y><V><S><Y><Y><D><Y><F><I><A><S><C><E><I><T><F><C><I><F><L><F><V><F><T><T><Q><E><V><K><K><I><K><E><F><K><S><A><Y><F><K><S><I><W><N><W><L><E><L><L><L><L><L><L><C><F><V><A><V><S><F><N><T><Y><Y><N><V><Q><I><F><L><L><L><G><Q><L><L><K><S><T><E><K><Y><S><D><F><Y><F><L><A><C><W><H><I><Y><Y><N><N><I><I><A><I><T><I><F><F><A><W><I><K><I><F><K><F><I><S><F><N><K><T><M><S><Q><L><S><S><T><L><S><R><C><V><K><D><I><V><G><F><A><I><M><F><F><I><I><F><F><A><Y><A><Q><L><G><F><L><V><F><G><S><Q><V><D><D><F><S><T><F><Q><N><S><I><F><A><Q><F><R><I><V><L><G><D><F><N><F><A><G><I><Q><Q><A><N><P><I><L><G><P><I><Y><F><I><T><F><I><F><F><V><F><F><V><L><L><N><M><F><L><A><I><I><N><D><T><Y><S><E><V><K><A><D><Y><S><I><G><R><R><L><D><F><E><L><G><K><M><I><K><Q><S><Y><K><N><V><L><E><K><F><R><L><K><K><A><Q><K><D><E><D><K><K><T><K><G><S><G><D><L><A><E><Q><A><R><R><E><G><F><D><E><N><E><I><Q><N><A><E><Q><M><K><K><W><K><E><R><L><E><K><K><Y><Y><S><M><E><I><Q><D><D><Y><Q><P><V><T><Q><E><E><F><R><E><L><F><L><Y><A><V><E><L><E><K><E><L><H><Y><I><N><L><K><L><N><Q><V><V><R><K><V><S><A><L> | May function as a subunit of a cation channel and play a role in fertilization.<BOP> | Q9NZM6 |
P22794 | EVI2A_HUMAN | Ecotropic viral integration site 2A protein homolog | Homo | <M><P><T><D><M><E><H><T><G><H><Y><L><H><L><A><F><L><M><T><T><V><F><S><L><S><P><G><T><K><A><N><Y><T><R><L><W><A><N><S><T><S><S><W><D><S><V><I><Q><N><K><T><G><R><N><Q><N><E><N><I><N><T><N><P><I><T><P><E><V><D><Y><K><G><N><S><T><N><M><P><E><T><S><H><I><V><A><L><T><S><K><S><E><Q><E><L><Y><I><P><S><V><V><S><N><S><P><S><T><V><Q><S><I><E><N><T><S><K><S><H><G><E><I><F><K><K><D><V><C><A><E><N><N><N><N><M><A><M><L><I><C><L><I><I><I><A><V><L><F><L><I><C><T><F><L><F><L><S><T><V><V><L><A><N><K><V><S><S><L><R><R><S><K><Q><V><G><K><R><Q><P><R><S><N><G><D><F><L><A><S><G><L><W><P><A><E><S><D><T><W><K><R><T><K><Q><L><T><G><P><N><L><V><M><Q><S><T><G><V><L><T><A><T><R><E><R><K><D><E><E><G><T><E><K><L><T><N><K><Q><I><G> | May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.<BOP> | P22794 |
Q7Z434 | MAVS_HUMAN | Virus-induced-signaling adapter | Homo | <M><P><F><A><E><D><K><T><Y><K><Y><I><C><R><N><F><S><N><F><C><N><V><D><V><V><E><I><L><P><Y><L><P><C><L><T><A><R><D><Q><D><R><L><R><A><T><C><T><L><S><G><N><R><D><T><L><W><H><L><F><N><T><L><Q><R><R><P><G><W><V><E><Y><F><I><A><A><L><R><G><C><E><L><V><D><L><A><D><E><V><A><S><V><Y><Q><S><Y><Q><P><R><T><S><D><R><P><P><D><P><L><E><P><P><S><L><P><A><E><R><P><G><P><P><T><P><A><A><A><H><S><I><P><Y><N><S><C><R><E><K><E><P><S><Y><P><M><P><V><Q><E><T><Q><A><P><E><S><P><G><E><N><S><E><Q><A><L><Q><T><L><S><P><R><A><I><P><R><N><P><D><G><G><P><L><E><S><S><S><D><L><A><A><L><S><P><L><T><S><S><G><H><Q><E><Q><D><T><E><L><G><S><T><H><T><A><G><A><T><S><S><L><T><P><S><R><G><P><V><S><P><S><V><S><F><Q><P><L><A><R><S><T><P><R><A><S><R><L><P><G><P><T><G><S><V><V><S><T><G><T><S><F><S><S><S><S><P><G><L><A><S><A><G><A><A><E><G><K><Q><G><A><E><S><D><Q><A><E><P><I><I><C><S><S><G><A><E><A><P><A><N><S><L><P><S><K><V><P><T><T><L><M><P><V><N><T><V><A><L><K><V><P><A><N><P><A><S><V><S><T><V><P><S><K><L><P><T><S><S><K><P><P><G><A><V><P><S><N><A><L><T><N><P><A><P><S><K><L><P><I><N><S><T><R><A><G><M><V><P><S><K><V><P><T><S><M><V><L><T><K><V><S><A><S><T><V><P><T><D><G><S><S><R><N><E><E><T><P><A><A><P><T><P><A><G><A><T><G><G><S><S><A><W><L><D><S><S><S><E><N><R><G><L><G><S><E><L><S><K><P><G><V><L><A><S><Q><V><D><S><P><F><S><G><C><F><E><D><L><A><I><S><A><S><T><S><L><G><M><G><P><C><H><G><P><E><E><N><E><Y><K><S><E><G><T><F><G><I><H><V><A><E><N><P><S><I><Q><L><L><E><G><N><P><G><P><P><A><D><P><D><G><G><P><R><P><Q><A><D><R><K><F><Q><E><R><E><V><P><C><H><R><P><S><P><G><A><L><W><L><Q><V><A><V><T><G><V><L><V><V><T><L><L><V><V><L><Y><R><R><R><L><H> | Required for innate immune defense against viruses . Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) . Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state . Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response . May activate the same pathways following detection of extracellular dsRNA by TLR3 . May protect cells from apoptosis .<BOP> | Q7Z434 |
Q8NFU4 | FDSCP_HUMAN | Follicular dendritic cell secreted peptide | Homo | <M><K><K><V><L><L><L><I><T><A><I><L><A><V><A><V><G><F><P><V><S><Q><D><Q><E><R><E><K><R><S><I><S><D><S><D><E><L><A><S><G><F><F><V><F><P><Y><P><Y><P><F><R><P><L><P><P><I><P><F><P><R><F><P><W><F><R><R><N><F><P><I><P><I><P><E><S><A><P><T><T><P><L><P><S><E><K> | Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.<BOP> | Q8NFU4 |
Q9P1A2 | PP4RL_HUMAN | Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like | Homo | <M><A><E><I><P><L><Y><F><V><D><L><Q><D><D><L><D><D><Y><G><F><E><D><Y><G><T><D><C><D><N><M><R><V><T><A><F><L><D><I><P><G><Q><D><N><L><P><P><L><T><R><L><E><K><Y><A><F><S><E><N><T><F><N><R><Q><I><I><A><R><G><L><L><D><I><F><R><D><F><G><N><N><E><E><D><F><L><T><V><M><E><I><V><V><R><L><S><E><D><A><E><P><T><V><R><T><E><L><M><E><Q><I><P><P><I><A><I><F><L><Q><E><N><R><S><N><F><P><V><V><L><S><E><Y><L><I><P><I><V><V><R><Y><L><T><D><P><N><N><Q><I><I><C><K><M><A><S><M><L><S><K><S><T><V><E><R><L><L><L><P><R><F><C><E><L><C><G><D><R><K><L><F><Q><V><R><K><V><C><A><A><N><F><G><D><I><C><H><A><V><G><Q><E><A><T><E><K><F><L><I><P><K><F><F><E><L><C><S><D><A><V><W><G><M><R><K><A><C><A><E><C><F><T><A><V><S><H><S><S><S><P><G><V><R><R><T><Q><L><F><P><L><F><I><R><L><V><S><D><P><C><R><W><V><H><Q><A><A><F><Q><S><L><G><P><F><T><S><T><F><A><N><P><S><R><A><G><L><Y><L><R><E><D><G><A><L><S><I><W><P><L><T><Q><D><L><D><S><G><F><A><S><G><S><P><A><P><S><S><G><G><N><T><S><P><A><S><L><T><R><S><A><K><P><V><R><S><E><P><E><L><P><V><E><G><T><S><A><K><T><S><D><C><P><H><S><S><S><S><S><D><G><P><A><E><S><P><V><E><S><C><V><S><A><G><A><E><W><T><R><V><S><P><E><T><S><A><C><S><K><L><S><D><M><N><D><L><P><I><S><S><Y><P><G><S><D><S><W><A><C><P><G><N><T><E><D><V><F><S><H><F><L><Y><W> | May be a regulatory subunit of serine/threonine-protein phosphatase 4.<BOP> | Q9P1A2 |
P07357 | CO8A_HUMAN | Complement component 8 subunit alpha | Homo | <M><F><A><V><V><F><F><I><L><S><L><M><T><C><Q><P><G><V><T><A><Q><E><K><V><N><Q><R><V><R><R><A><A><T><P><A><A><V><T><C><Q><L><S><N><W><S><E><W><T><D><C><F><P><C><Q><D><K><K><Y><R><H><R><S><L><L><Q><P><N><K><F><G><G><T><I><C><S><G><D><I><W><D><Q><A><S><C><S><S><S><T><T><C><V><R><Q><A><Q><C><G><Q><D><F><Q><C><K><E><T><G><R><C><L><K><R><H><L><V><C><N><G><D><Q><D><C><L><D><G><S><D><E><D><D><C><E><D><V><R><A><I><D><E><D><C><S><Q><Y><E><P><I><P><G><S><Q><K><A><A><L><G><Y><N><I><L><T><Q><E><D><A><Q><S><V><Y><D><A><S><Y><Y><G><G><Q><C><E><T><V><Y><N><G><E><W><R><E><L><R><Y><D><S><T><C><E><R><L><Y><Y><G><D><D><E><K><Y><F><R><K><P><Y><N><F><L><K><Y><H><F><E><A><L><A><D><T><G><I><S><S><E><F><Y><D><N><A><N><D><L><L><S><K><V><K><K><D><K><S><D><S><F><G><V><T><I><G><I><G><P><A><G><S><P><L><L><V><G><V><G><V><S><H><S><Q><D><T><S><F><L><N><E><L><N><K><Y><N><E><K><K><F><I><F><T><R><I><F><T><K><V><Q><T><A><H><F><K><M><R><K><D><D><I><M><L><D><E><G><M><L><Q><S><L><M><E><L><P><D><Q><Y><N><Y><G><M><Y><A><K><F><I><N><D><Y><G><T><H><Y><I><T><S><G><S><M><G><G><I><Y><E><Y><I><L><V><I><D><K><A><K><M><E><S><L><G><I><T><S><R><D><I><T><T><C><F><G><G><S><L><G><I><Q><Y><E><D><K><I><N><V><G><G><G><L><S><G><D><H><C><K><K><F><G><G><G><K><T><E><R><A><R><K><A><M><A><V><E><D><I><I><S><R><V><R><G><G><S><S><G><W><S><G><G><L><A><Q><N><R><S><T><I><T><Y><R><S><W><G><R><S><L><K><Y><N><P><V><V><I><D><F><E><M><Q><P><I><H><E><V><L><R><H><T><S><L><G><P><L><E><A><K><R><Q><N><L><R><R><A><L><D><Q><Y><L><M><E><F><N><A><C><R><C><G><P><C><F><N><N><G><V><P><I><L><E><G><T><S><C><R><C><Q><C><R><L><G><S><L><G><A><A><C><E><Q><T><Q><T><E><G><A><K><A><D><G><S><W><S><C><W><S><S><W><S><V><C><R><A><G><I><Q><E><R><R><R><E><C><D><N><P><A><P><Q><N><G><G><A><S><C><P><G><R><K><V><Q><T><Q><A><C> | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<BOP> | P07357 |
Q9UQ03 | COR2B_HUMAN | Protein FC96 | Homo | <M><T><V><T><K><M><S><W><R><P><Q><Y><R><S><S><K><F><R><N><V><Y><G><K><V><A><N><R><E><H><C><F><D><G><I><P><I><T><K><N><V><H><D><N><H><F><C><A><V><N><T><R><F><L><A><I><V><T><E><S><A><G><G><G><S><F><L><V><I><P><L><E><Q><T><G><R><I><E><P><N><Y><P><K><V><C><G><H><Q><G><N><V><L><D><I><K><W><N><P><F><I><D><N><I><I><A><S><C><S><E><D><T><S><V><R><I><W><E><I><P><E><G><G><L><K><R><N><M><T><E><A><L><L><E><L><H><G><H><S><R><R><V><G><L><V><E><W><H><P><T><T><N><N><I><L><F><S><A><G><Y><D><Y><K><V><L><I><W><N><L><D><V><G><E><P><V><K><M><I><D><C><H><T><D><V><I><L><C><M><S><F><N><T><D><G><S><L><L><T><T><T><C><K><D><K><K><L><R><V><I><E><P><R><S><G><R><V><L><Q><E><A><N><C><K><N><H><R><V><N><R><V><V><F><L><G><N><M><K><R><L><L><T><T><G><V><S><R><W><N><T><R><Q><I><A><L><W><D><Q><E><D><L><S><M><P><L><I><E><E><E><I><D><G><L><S><G><L><L><F><P><F><Y><D><A><D><T><H><M><L><Y><L><A><G><K><G><D><G><N><I><R><Y><Y><E><I><S><T><E><K><P><Y><L><S><Y><L><M><E><F><R><S><P><A><P><Q><K><G><L><G><V><M><P><K><H><G><L><D><V><S><A><C><E><V><F><R><F><Y><K><L><V><T><L><K><G><L><I><E><P><I><S><M><I><V><P><R><R><S><D><S><Y><Q><E><D><I><Y><P><M><T><P><G><T><E><P><A><L><T><P><D><E><W><L><G><G><I><N><R><D><P><V><L><M><S><L><K><E><G><Y><K><K><S><S><K><M><V><F><K><A><P><I><K><E><K><K><S><V><V><V><N><G><I><D><L><L><E><N><V><P><P><R><T><E><N><E><L><L><R><M><F><F><R><Q><Q><D><E><I><R><R><L><K><E><E><L><A><Q><K><D><I><R><I><R><Q><L><Q><L><E><L><K><N><L><R><N><S><P><K><N><C> | May play a role in the reorganization of neuronal actin structure.<BOP> | Q9UQ03 |
P49913 | CAMP_HUMAN | Antibacterial peptide LL-37 | Homo | <M><K><T><Q><R><D><G><H><S><L><G><R><W><S><L><V><L><L><L><L><G><L><V><M><P><L><A><I><I><A><Q><V><L><S><Y><K><E><A><V><L><R><A><I><D><G><I><N><Q><R><S><S><D><A><N><L><Y><R><L><L><D><L><D><P><R><P><T><M><D><G><D><P><D><T><P><K><P><V><S><F><T><V><K><E><T><V><C><P><R><T><T><Q><Q><S><P><E><D><C><D><F><K><K><D><G><L><V><K><R><C><M><G><T><V><T><L><N><Q><A><R><G><S><F><D><I><S><C><D><K><D><N><K><R><F><A><L><L><G><D><F><F><R><K><S><K><E><K><I><G><K><E><F><K><R><I><V><Q><R><I><K><D><F><L><R><N><L><V><P><R><T><E><S> | Binds to bacterial lipopolysaccharides (LPS) and has antibacterial activity . Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 .<BOP> | P49913 |
Q93079 | H2B1H_HUMAN | Histone H2B.j | Homo | <M><P><D><P><A><K><S><A><P><A><P><K><K><G><S><K><K><A><V><T><K><A><Q><K><K><D><G><K><K><R><K><R><S><R><K><E><S><Y><S><V><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><G><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><E><I><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><S><K> | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP> | Q93079 |
O00167 | EYA2_HUMAN | Eyes absent homolog 2 | Homo | <M><V><E><L><V><I><S><P><S><L><T><V><N><S><D><C><L><D><K><L><K><F><N><R><A><D><A><A><V><W><T><L><S><D><R><Q><G><I><T><K><S><A><P><L><R><V><S><Q><L><F><S><R><S><C><P><R><V><L><P><R><Q><P><S><T><A><M><A><A><Y><G><Q><T><Q><Y><S><A><G><I><Q><Q><A><T><P><Y><T><A><Y><P><P><P><A><Q><A><Y><G><I><P><S><Y><S><I><K><T><E><D><S><L><N><H><S><P><G><Q><S><G><F><L><S><Y><G><S><S><F><S><T><S><P><T><G><Q><S><P><Y><T><Y><Q><M><H><G><T><T><G><F><Y><Q><G><G><N><G><L><G><N><A><A><G><F><G><S><V><H><Q><D><Y><P><S><Y><P><G><F><P><Q><S><Q><Y><P><Q><Y><Y><G><S><S><Y><N><P><P><Y><V><P><A><S><S><I><C><P><S><P><L><S><T><S><T><Y><V><L><Q><E><A><S><H><N><V><P><N><Q><S><S><E><S><L><A><G><E><Y><N><T><H><N><G><P><S><T><P><A><K><E><G><D><T><D><R><P><H><R><A><S><D><G><K><L><R><G><R><S><K><R><S><S><D><P><S><P><A><G><D><N><E><I><E><R><V><F><V><W><D><L><D><E><T><I><I><I><F><H><S><L><L><T><G><T><F><A><S><R><Y><G><K><D><T><T><T><S><V><R><I><G><L><M><M><E><E><M><I><F><N><L><A><D><T><H><L><F><F><N><D><L><E><D><C><D><Q><I><H><V><D><D><V><S><S><D><D><N><G><Q><D><L><S><T><Y><N><F><S><A><D><G><F><H><S><S><A><P><G><A><N><L><C><L><G><S><G><V><H><G><G><V><D><W><M><R><K><L><A><F><R><Y><R><R><V><K><E><M><Y><N><T><Y><K><N><N><V><G><G><L><I><G><T><P><K><R><E><T><W><L><Q><L><R><A><E><L><E><A><L><T><D><L><W><L><T><H><S><L><K><A><L><N><L><I><N><S><R><P><N><C><V><N><V><L><V><T><T><T><Q><L><I><P><A><L><A><K><V><L><L><Y><G><L><G><S><V><F><P><I><E><N><I><Y><S><A><T><K><T><G><K><E><S><C><F><E><R><I><M><Q><R><F><G><R><K><A><V><Y><V><V><I><G><D><G><V><E><E><E><Q><G><A><K><K><H><N><M><P><F><W><R><I><S><C><H><A><D><L><E><A><L><R><H><A><L><E><L><E><Y><L> | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 . Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress . Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 .<BOP> | O00167 |
Q5JST6 | EFHC2_HUMAN | EF-hand domain-containing family member C2 | Homo | <M><A><L><P><L><L><P><G><N><S><F><N><R><N><V><G><K><E><K><F><H><K><S><Q><H><W><G><F><C><N><N><V><M><M><L><V><S><D><E><K><P><G><I><G><G><E><P><L><L><G><Q><K><I><K><P><K><C><S><I><Y><P><K><G><D><G><S><D><V><P><S><W><V><A><F><D><K><Q><V><L><S><F><D><A><Y><L><E><E><E><V><L><D><K><S><Q><T><N><Y><R><I><R><Y><Y><K><I><Y><F><Y><P><E><D><D><T><I><Q><V><N><E><P><E><V><K><N><S><G><L><L><Q><G><T><S><I><R><R><H><R><I><T><L><P><P><P><D><E><D><Q><F><Y><T><V><Y><H><F><N><V><G><T><E><V><V><F><Y><G><R><T><F><K><I><Y><D><C><D><A><F><T><R><N><F><L><R><K><I><G><V><K><V><N><P><P><V><Q><C><P><E><D><P><Y><M><K><I><R><R><E><V><V><E><H><V><E><P><L><R><P><Y><E><S><L><D><T><L><K><Q><F><L><Q><Y><H><G><K><I><L><C><F><F><C><L><W><D><D><S><V><S><M><F><G><D><R><R><E><L><I><L><H><Y><F><L><C><D><D><T><I><E><I><K><E><L><L><P><H><S><S><G><R><D><A><L><K><M><F><L><R><R><S><K><L><P><K><N><C><P><P><R><V><Y><Q><P><G><Q><I><T><D><R><A><V><L><N><S><Y><G><D><F><I><K><N><Q><A><D><G><Y><L><F><D><R><Y><K><L><G><K><V><D><Q><E><F><Y><K><D><S><D><L><S><L><G><V><T><I><N><V><W><G><R><K><V><L><L><Y><D><C><D><E><F><T><K><S><Y><Y><K><S><K><Y><G><I><E><N><F><T><S><V><S><C><K><P><P><S><P><P><P><K><I><E><R><K><F><P><P><Y><N><G><F><G><S><E><E><D><S><L><R><N><C><I><D><L><K><P><T><P><H><R><R><N><F><K><K><F><M><E><K><D><S><Y><G><S><K><S><N><I><L><R><F><F><A><K><L><V><T><D><K><C><V><D><L><D><R><M><F><V><I><S><Y><Y><L><G><D><D><T><I><S><V><F><E><P><I><E><R><N><S><G><I><A><G><G><M><F><L><K><R><S><R><V><K><K><P><G><Q><E><V><F><K><S><E><L><S><E><Y><I><K><A><E><E><L><Y><I><G><V><T><V><N><V><N><G><Y><L><F><R><L><L><N><A><D><E><Y><T><L><N><Y><M><E><Q><N><T><D><K><Y><P><F><S><N><L><K><L><A><L><Q><K><L><K><Q><E><E><G><K><S><R><E><L><K><Q><V><F><K><A><A><D><S><K><H><T><N><M><V><D><Y><N><T><F><R><D><I><L><M><S><L><T><V><G><N><L><A><E><Q><E><F><V><T><I><A><R><H><Y><R><V><P><E><G><T><C><S><D><M><D><F><L><I><A><L><A><H><E><K><F><K><K><N><M><F><E><N><F><D><T><F><I><Y><S><C><V><Y><E><D><R><E><K><K><N><V><L><P><T><K><D><I><K><R><L><C><K><S><S><R><L><P><L><S><D><D><L><L><E><S><L><L><S><R><F><E><D><S><E><K><Q><I><D><Y><K><S><F><F><S><A><L><N><W><R><K><N><P><V><P><E><L><Q><P><A><S><Y><L><K><E><R><C><E><D><V><W><L><G><M><P><S><P><I><P><A><K><Y><I><D><Y><W><T><F><L><K><D><A><F><G><L><E><E><E> | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.<BOP> | Q5JST6 |
Q9Y2Y9 | KLF13_HUMAN | Transcription factor NSLP1 | Homo | <M><A><A><A><A><Y><V><D><H><F><A><A><E><C><L><V><S><M><S><S><R><A><V><V><H><G><P><R><E><G><P><E><S><R><P><E><G><A><A><V><A><A><T><P><T><L><P><R><V><E><E><R><R><D><G><K><D><S><A><S><L><F><V><V><A><R><I><L><A><D><L><N><Q><Q><A><P><A><P><A><P><A><E><R><R><E><G><A><A><A><R><K><A><R><T><P><C><R><L><P><P><P><A><P><E><P><T><S><P><G><A><E><G><A><A><A><A><P><P><S><P><A><W><S><E><P><E><P><E><A><G><L><E><P><E><R><E><P><G><P><A><G><S><G><E><P><G><L><R><Q><R><V><R><R><G><R><S><R><A><D><L><E><S><P><Q><R><K><H><K><C><H><Y><A><G><C><E><K><V><Y><G><K><S><S><H><L><K><A><H><L><R><T><H><T><G><E><R><P><F><A><C><S><W><Q><D><C><N><K><K><F><A><R><S><D><E><L><A><R><H><Y><R><T><H><T><G><E><K><K><F><S><C><P><I><C><E><K><R><F><M><R><S><D><H><L><T><K><H><A><R><R><H><A><N><F><H><P><G><M><L><Q><R><R><G><G><G><S><R><T><G><S><L><S><D><Y><S><R><S><D><A><S><S><P><T><I><S><P><A><S><S><P> | Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.<BOP> | Q9Y2Y9 |
P08254 | MMP3_HUMAN | Transin-1 | Homo | <M><K><S><L><P><I><L><L><L><L><C><V><A><V><C><S><A><Y><P><L><D><G><A><A><R><G><E><D><T><S><M><N><L><V><Q><K><Y><L><E><N><Y><Y><D><L><K><K><D><V><K><Q><F><V><R><R><K><D><S><G><P><V><V><K><K><I><R><E><M><Q><K><F><L><G><L><E><V><T><G><K><L><D><S><D><T><L><E><V><M><R><K><P><R><C><G><V><P><D><V><G><H><F><R><T><F><P><G><I><P><K><W><R><K><T><H><L><T><Y><R><I><V><N><Y><T><P><D><L><P><K><D><A><V><D><S><A><V><E><K><A><L><K><V><W><E><E><V><T><P><L><T><F><S><R><L><Y><E><G><E><A><D><I><M><I><S><F><A><V><R><E><H><G><D><F><Y><P><F><D><G><P><G><N><V><L><A><H><A><Y><A><P><G><P><G><I><N><G><D><A><H><F><D><D><D><E><Q><W><T><K><D><T><T><G><T><N><L><F><L><V><A><A><H><E><I><G><H><S><L><G><L><F><H><S><A><N><T><E><A><L><M><Y><P><L><Y><H><S><L><T><D><L><T><R><F><R><L><S><Q><D><D><I><N><G><I><Q><S><L><Y><G><P><P><P><D><S><P><E><T><P><L><V><P><T><E><P><V><P><P><E><P><G><T><P><A><N><C><D><P><A><L><S><F><D><A><V><S><T><L><R><G><E><I><L><I><F><K><D><R><H><F><W><R><K><S><L><R><K><L><E><P><E><L><H><L><I><S><S><F><W><P><S><L><P><S><G><V><D><A><A><Y><E><V><T><S><K><D><L><V><F><I><F><K><G><N><Q><F><W><A><I><R><G><N><E><V><R><A><G><Y><P><R><G><I><H><T><L><G><F><P><P><T><V><R><K><I><D><A><A><I><S><D><K><E><K><N><K><T><Y><F><F><V><E><D><K><Y><W><R><F><D><E><K><R><N><S><M><E><P><G><F><P><K><Q><I><A><E><D><F><P><G><I><D><S><K><I><D><A><V><F><E><E><F><G><F><F><Y><F><F><T><G><S><S><Q><L><E><F><D><P><N><A><K><K><V><T><H><T><L><K><S><N><S><W><L><N><C> | Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.<BOP> | P08254 |
P17342 | ANPRC_HUMAN | Atrial natriuretic peptide receptor type C | Homo | <M><P><S><L><L><V><L><T><F><S><P><C><V><L><L><G><W><A><L><L><A><G><G><T><G><G><G><G><V><G><G><G><G><G><G><A><G><I><G><G><G><R><Q><E><R><E><A><L><P><P><Q><K><I><E><V><L><V><L><L><P><Q><D><D><S><Y><L><F><S><L><T><R><V><R><P><A><I><E><Y><A><L><R><S><V><E><G><N><G><T><G><R><R><L><L><P><P><G><T><R><F><Q><V><A><Y><E><D><S><D><C><G><N><R><A><L><F><S><L><V><D><R><V><A><A><A><R><G><A><K><P><D><L><I><L><G><P><V><C><E><Y><A><A><A><P><V><A><R><L><A><S><H><W><D><L><P><M><L><S><A><G><A><L><A><A><G><F><Q><H><K><D><S><E><Y><S><H><L><T><R><V><A><P><A><Y><A><K><M><G><E><M><M><L><A><L><F><R><H><H><H><W><S><R><A><A><L><V><Y><S><D><D><K><L><E><R><N><C><Y><F><T><L><E><G><V><H><E><V><F><Q><E><E><G><L><H><T><S><I><Y><S><F><D><E><T><K><D><L><D><L><E><D><I><V><R><N><I><Q><A><S><E><R><V><V><I><M><C><A><S><S><D><T><I><R><S><I><M><L><V><A><H><R><H><G><M><T><S><G><D><Y><A><F><F><N><I><E><L><F><N><S><S><S><Y><G><D><G><S><W><K><R><G><D><K><H><D><F><E><A><K><Q><A><Y><S><S><L><Q><T><V><T><L><L><R><T><V><K><P><E><F><E><K><F><S><M><E><V><K><S><S><V><E><K><Q><G><L><N><M><E><D><Y><V><N><M><F><V><E><G><F><H><D><A><I><L><L><Y><V><L><A><L><H><E><V><L><R><A><G><Y><S><K><K><D><G><G><K><I><I><Q><Q><T><W><N><R><T><F><E><G><I><A><G><Q><V><S><I><D><A><N><G><D><R><Y><G><D><F><S><V><I><A><M><T><D><V><E><A><G><T><Q><E><V><I><G><D><Y><F><G><K><E><G><R><F><E><M><R><P><N><V><K><Y><P><W><G><P><L><K><L><R><I><D><E><N><R><I><V><E><H><T><N><S><S><P><C><K><S><S><G><G><L><E><E><S><A><V><T><G><I><V><V><G><A><L><L><G><A><G><L><L><M><A><F><Y><F><F><R><K><K><Y><R><I><T><I><E><R><R><T><Q><Q><E><E><S><N><L><G><K><H><R><E><L><R><E><D><S><I><R><S><H><F><S><V><A> | Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.<BOP> | P17342 |
P12319 | FCERA_HUMAN | IgE Fc receptor subunit alpha | Homo | <M><A><P><A><M><E><S><P><T><L><L><C><V><A><L><L><F><F><A><P><D><G><V><L><A><V><P><Q><K><P><K><V><S><L><N><P><P><W><N><R><I><F><K><G><E><N><V><T><L><T><C><N><G><N><N><F><F><E><V><S><S><T><K><W><F><H><N><G><S><L><S><E><E><T><N><S><S><L><N><I><V><N><A><K><F><E><D><S><G><E><Y><K><C><Q><H><Q><Q><V><N><E><S><E><P><V><Y><L><E><V><F><S><D><W><L><L><L><Q><A><S><A><E><V><V><M><E><G><Q><P><L><F><L><R><C><H><G><W><R><N><W><D><V><Y><K><V><I><Y><Y><K><D><G><E><A><L><K><Y><W><Y><E><N><H><N><I><S><I><T><N><A><T><V><E><D><S><G><T><Y><Y><C><T><G><K><V><W><Q><L><D><Y><E><S><E><P><L><N><I><T><V><I><K><A><P><R><E><K><Y><W><L><Q><F><F><I><P><L><L><V><V><I><L><F><A><V><D><T><G><L><F><I><S><T><Q><Q><Q><V><T><F><L><L><K><I><K><R><T><R><K><G><F><R><L><L><N><P><H><P><K><P><N><P><K><N><N> | Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.<BOP> | P12319 |
O95299 | NDUAA_HUMAN | NADH-ubiquinone oxidoreductase 42 kDa subunit | Homo | <M><A><L><R><L><L><K><L><A><A><T><S><A><S><A><R><V><V><A><A><G><A><Q><R><V><R><G><I><H><S><S><V><Q><C><K><L><R><Y><G><M><W><H><F><L><L><G><D><K><A><S><K><R><L><T><E><R><S><R><V><I><T><V><D><G><N><I><C><T><G><K><G><K><L><A><K><E><I><A><E><K><L><G><F><K><H><F><P><E><A><G><I><H><Y><P><D><S><T><T><G><D><G><K><P><L><A><T><D><Y><N><G><N><C><S><L><E><K><F><Y><D><D><P><R><S><N><D><G><N><S><Y><R><L><Q><S><W><L><Y><S><S><R><L><L><Q><Y><S><D><A><L><E><H><L><L><T><T><G><Q><G><V><V><L><E><R><S><I><F><S><D><F><V><F><L><E><A><M><Y><N><Q><G><F><I><R><K><Q><C><V><D><H><Y><N><E><V><K><S><V><T><I><C><D><Y><L><P><P><H><L><V><I><Y><I><D><V><P><V><P><E><V><Q><R><R><I><Q><K><K><G><D><P><H><E><M><K><I><T><S><A><Y><L><Q><D><I><E><N><A><Y><K><K><T><F><L><P><E><M><S><E><K><C><E><V><L><Q><Y><S><A><R><E><A><Q><D><S><K><K><V><V><E><D><I><E><Y><L><K><F><D><K><G><P><W><L><K><Q><D><N><R><T><L><Y><H><L><R><L><L><V><Q><D><K><F><E><V><L><N><Y><T><S><I><P><I><F><L><P><E><V><T><I><G><A><H><Q><T><D><R><V><L><H><Q><F><R><E><L><P><G><R><K><Y><S><P><G><Y><N><T><E><V><G><D><K><W><I><W><L><K> | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.<BOP> | O95299 |
Q86TA1 | MOB3B_HUMAN | Mps one binder kinase activator-like 2B | Homo | <M><S><I><A><L><K><Q><V><F><N><K><D><K><T><F><R><P><K><R><K><F><E><P><G><T><Q><R><F><E><L><H><K><R><A><Q><A><S><L><N><S><G><V><D><L><K><A><A><V><Q><L><P><S><G><E><D><Q><N><D><W><V><A><V><H><V><V><D><F><F><N><R><I><N><L><I><Y><G><T><I><C><E><F><C><T><E><R><T><C><P><V><M><S><G><G><P><K><Y><E><Y><R><W><Q><D><D><L><K><Y><K><K><P><T><A><L><P><A><P><Q><Y><M><N><L><L><M><D><W><I><E><V><Q><I><N><N><E><E><I><F><P><T><C><V><G><V><P><F><P><K><N><F><L><Q><I><C><K><K><I><L><C><R><L><F><R><V><F><V><H><V><Y><I><H><H><F><D><R><V><I><V><M><G><A><E><A><H><V><N><T><C><Y><K><H><F><Y><Y><F><V><T><E><M><N><L><I><D><R><K><E><L><E><P><L><K><E><M><T><S><R><M><C><H> | Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.<BOP> | Q86TA1 |
Q9UNE0 | EDAR_HUMAN | Ectodysplasin-A receptor | Homo | <M><A><H><V><G><D><C><T><Q><T><P><W><L><P><V><L><V><V><S><L><M><C><S><A><R><A><E><Y><S><N><C><G><E><N><E><Y><Y><N><Q><T><T><G><L><C><Q><E><C><P><P><C><G><P><G><E><E><P><Y><L><S><C><G><Y><G><T><K><D><E><D><Y><G><C><V><P><C><P><A><E><K><F><S><K><G><G><Y><Q><I><C><R><R><H><K><D><C><E><G><F><F><R><A><T><V><L><T><P><G><D><M><E><N><D><A><E><C><G><P><C><L><P><G><Y><Y><M><L><E><N><R><P><R><N><I><Y><G><M><V><C><Y><S><C><L><L><A><P><P><N><T><K><E><C><V><G><A><T><S><G><A><S><A><N><F><P><G><T><S><G><S><S><T><L><S><P><F><Q><H><A><H><K><E><L><S><G><Q><G><H><L><A><T><A><L><I><I><A><M><S><T><I><F><I><M><A><I><A><I><V><L><I><I><M><F><Y><I><L><K><T><K><P><S><A><P><A><C><C><T><S><H><P><G><K><S><V><E><A><Q><V><S><K><D><E><E><K><K><E><A><P><D><N><V><V><M><F><S><E><K><D><E><F><E><K><L><T><A><T><P><A><K><P><T><K><S><E><N><D><A><S><S><E><N><E><Q><L><L><S><R><S><V><D><S><D><E><E><P><A><P><D><K><Q><G><S><P><E><L><C><L><L><S><L><V><H><L><A><R><E><K><S><A><T><S><N><K><S><A><G><I><Q><S><R><R><K><K><I><L><D><V><Y><A><N><V><C><G><V><V><E><G><L><S><P><T><E><L><P><F><D><C><L><E><K><T><S><R><M><L><S><S><T><Y><N><S><E><K><A><V><V><K><T><W><R><H><L><A><E><S><F><G><L><K><R><D><E><I><G><G><M><T><D><G><M><Q><L><F><D><R><I><S><T><A><G><Y><S><I><P><E><L><L><T><K><L><V><Q><I><E><R><L><D><A><V><E><S><L><C><A><D><I><L><E><W><A><G><V><V><P><P><A><S><Q><P><H><A><A><S> | Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.<BOP> | Q9UNE0 |
P32242 | OTX1_HUMAN | Orthodenticle homolog 1 | Homo | <M><M><S><Y><L><K><Q><P><P><Y><G><M><N><G><L><G><L><A><G><P><A><M><D><L><L><H><P><S><V><G><Y><P><A><T><P><R><K><Q><R><R><E><R><T><T><F><T><R><S><Q><L><D><V><L><E><A><L><F><A><K><T><R><Y><P><D><I><F><M><R><E><E><V><A><L><K><I><N><L><P><E><S><R><V><Q><V><W><F><K><N><R><R><A><K><C><R><Q><Q><Q><Q><S><G><S><G><T><K><S><R><P><A><K><K><K><S><S><P><V><R><E><S><S><G><S><E><S><S><G><Q><F><T><P><P><A><V><S><S><S><A><S><S><S><S><S><A><S><S><S><S><A><N><P><A><A><A><A><A><A><G><L><G><G><N><P><V><A><A><A><S><S><L><S><T><P><A><A><S><S><I><W><S><P><A><S><I><S><P><G><S><A><P><A><S><V><S><V><P><E><P><L><A><A><P><S><N><T><S><C><M><Q><R><S><V><A><A><G><A><A><T><A><A><A><S><Y><P><M><S><Y><G><Q><G><G><S><Y><G><Q><G><Y><P><T><P><S><S><S><Y><F><G><G><V><D><C><S><S><Y><L><A><P><M><H><S><H><H><H><P><H><Q><L><S><P><M><A><P><S><S><M><A><G><H><H><H><H><H><P><H><A><H><H><P><L><S><Q><S><S><G><H><H><H><H><H><H><H><H><H><H><Q><G><Y><G><G><S><G><L><A><F><N><S><A><D><C><L><D><Y><K><E><P><G><A><A><A><A><S><S><A><W><K><L><N><F><N><S><P><D><C><L><D><Y><K><D><Q><A><S><W><R><F><Q><V><L> | Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.<BOP> | P32242 |
P30040 | ERP29_HUMAN | Endoplasmic reticulum resident protein 31 | Homo | <M><A><A><A><V><P><R><A><A><F><L><S><P><L><L><P><L><L><L><G><F><L><L><L><S><A><P><H><G><G><S><G><L><H><T><K><G><A><L><P><L><D><T><V><T><F><Y><K><V><I><P><K><S><K><F><V><L><V><K><F><D><T><Q><Y><P><Y><G><E><K><Q><D><E><F><K><R><L><A><E><N><S><A><S><S><D><D><L><L><V><A><E><V><G><I><S><D><Y><G><D><K><L><N><M><E><L><S><E><K><Y><K><L><D><K><E><S><Y><P><V><F><Y><L><F><R><D><G><D><F><E><N><P><V><P><Y><T><G><A><V><K><V><G><A><I><Q><R><W><L><K><G><Q><G><V><Y><L><G><M><P><G><C><L><P><V><Y><D><A><L><A><G><E><F><I><R><A><S><G><V><E><A><R><Q><A><L><L><K><Q><G><Q><D><N><L><S><S><V><K><E><T><Q><K><K><W><A><E><Q><Y><L><K><I><M><G><K><I><L><D><Q><G><E><D><F><P><A><S><E><M><T><R><I><A><R><L><I><E><K><N><K><M><S><D><G><K><K><E><E><L><Q><K><S><L><N><I><L><T><A><F><Q><K><K><G><A><E><K><E><E><L> | Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.<BOP> | P30040 |
P50135 | HNMT_HUMAN | Histamine N-methyltransferase | Homo | <M><A><S><S><M><R><S><L><F><S><D><H><G><K><Y><V><E><S><F><R><R><F><L><N><H><S><T><E><H><Q><C><M><Q><E><F><M><D><K><K><L><P><G><I><I><G><R><I><G><D><T><K><S><E><I><K><I><L><S><I><G><G><G><A><G><E><I><D><L><Q><I><L><S><K><V><Q><A><Q><Y><P><G><V><C><I><N><N><E><V><V><E><P><S><A><E><Q><I><A><K><Y><K><E><L><V><A><K><T><S><N><L><E><N><V><K><F><A><W><H><K><E><T><S><S><E><Y><Q><S><R><M><L><E><K><K><E><L><Q><K><W><D><F><I><H><M><I><Q><M><L><Y><Y><V><K><D><I><P><A><T><L><K><F><F><H><S><L><L><G><T><N><A><K><M><L><I><I><V><V><S><G><S><S><G><W><D><K><L><W><K><K><Y><G><S><R><F><P><Q><D><D><L><C><Q><Y><I><T><S><D><D><L><T><Q><M><L><D><N><L><G><L><K><Y><E><C><Y><D><L><L><S><T><M><D><I><S><D><C><F><I><D><G><N><E><N><G><D><L><L><W><D><F><L><T><E><T><C><N><F><N><A><T><A><P><P><D><L><R><A><E><L><G><K><D><L><Q><E><P><E><F><S><A><K><K><E><G><K><V><L><F><N><N><T><L><S><F><I><V><I><E><A> | Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.<BOP> | P50135 |
Q9BRX2 | PELO_HUMAN | Protein pelota homolog | Homo | <M><K><L><V><R><K><N><I><E><K><D><N><A><G><Q><V><T><L><V><P><E><E><P><E><D><M><W><H><T><Y><N><L><V><Q><V><G><D><S><L><R><A><S><T><I><R><K><V><Q><T><E><S><S><T><G><S><V><G><S><N><R><V><R><T><T><L><T><L><C><V><E><A><I><D><F><D><S><Q><A><C><Q><L><R><V><K><G><T><N><I><Q><E><N><E><Y><V><K><M><G><A><Y><H><T><I><E><L><E><P><N><R><Q><F><T><L><A><K><K><Q><W><D><S><V><V><L><E><R><I><E><Q><A><C><D><P><A><W><S><A><D><V><A><A><V><V><M><Q><E><G><L><A><H><I><C><L><V><T><P><S><M><T><L><T><R><A><K><V><E><V><N><I><P><R><K><R><K><G><N><C><S><Q><H><D><R><A><L><E><R><F><Y><E><Q><V><V><Q><A><I><Q><R><H><I><H><F><D><V><V><K><C><I><L><V><A><S><P><G><F><V><R><E><Q><F><C><D><Y><L><F><Q><Q><A><V><K><T><D><N><K><L><L><L><E><N><R><S><K><F><L><Q><V><H><A><S><S><G><H><K><Y><S><L><K><E><A><L><C><D><P><T><V><A><S><R><L><S><D><T><K><A><A><G><E><V><K><A><L><D><D><F><Y><K><M><L><Q><H><E><P><D><R><A><F><Y><G><L><K><Q><V><E><K><A><N><E><A><M><A><I><D><T><L><L><I><S><D><E><L><F><R><H><Q><D><V><A><T><R><S><R><Y><V><R><L><V><D><S><V><K><E><N><A><G><T><V><R><I><F><S><S><L><H><V><S><G><E><Q><L><S><Q><L><T><G><V><A><A><I><L><R><F><P><V><P><E><L><S><D><Q><E><G><D><S><S><S><E><E><D> | Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway . In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes . Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway . As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy .<BOP> | Q9BRX2 |
Q16539 | MK14_HUMAN | Stress-activated protein kinase 2a | Homo | <M><S><Q><E><R><P><T><F><Y><R><Q><E><L><N><K><T><I><W><E><V><P><E><R><Y><Q><N><L><S><P><V><G><S><G><A><Y><G><S><V><C><A><A><F><D><T><K><T><G><L><R><V><A><V><K><K><L><S><R><P><F><Q><S><I><I><H><A><K><R><T><Y><R><E><L><R><L><L><K><H><M><K><H><E><N><V><I><G><L><L><D><V><F><T><P><A><R><S><L><E><E><F><N><D><V><Y><L><V><T><H><L><M><G><A><D><L><N><N><I><V><K><C><Q><K><L><T><D><D><H><V><Q><F><L><I><Y><Q><I><L><R><G><L><K><Y><I><H><S><A><D><I><I><H><R><D><L><K><P><S><N><L><A><V><N><E><D><C><E><L><K><I><L><D><F><G><L><A><R><H><T><D><D><E><M><T><G><Y><V><A><T><R><W><Y><R><A><P><E><I><M><L><N><W><M><H><Y><N><Q><T><V><D><I><W><S><V><G><C><I><M><A><E><L><L><T><G><R><T><L><F><P><G><T><D><H><I><D><Q><L><K><L><I><L><R><L><V><G><T><P><G><A><E><L><L><K><K><I><S><S><E><S><A><R><N><Y><I><Q><S><L><T><Q><M><P><K><M><N><F><A><N><V><F><I><G><A><N><P><L><A><V><D><L><L><E><K><M><L><V><L><D><S><D><K><R><I><T><A><A><Q><A><L><A><H><A><Y><F><A><Q><Y><H><D><P><D><D><E><P><V><A><D><P><Y><D><Q><S><F><E><S><R><D><L><L><I><D><E><W><K><S><L><T><Y><D><E><V><I><S><F><V><P><P><P><L><D><Q><E><E><M><E><S> | (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA .<BOP> | Q16539 |
A4D2G3 | O2A25_HUMAN | Olfactory receptor 2A27 | Homo | <M><G><G><N><Q><T><S><I><T><E><F><L><L><L><G><F><P><I><G><P><R><I><Q><M><L><L><F><G><L><F><S><L><F><Y><I><F><I><L><L><G><N><G><T><I><L><G><L><I><S><L><D><S><R><L><H><T><P><M><Y><F><F><L><S><H><L><A><V><V><D><I><A><C><A><C><S><T><V><P><Q><M><L><V><N><L><L><H><P><A><K><P><I><S><F><A><G><C><M><T><Q><M><F><L><F><L><S><F><A><H><T><E><C><L><L><L><V><V><M><S><Y><D><R><Y><V><A><I><C><H><P><L><R><Y><S><T><I><M><T><W><K><V><C><I><T><L><A><L><T><S><W><I><L><G><V><L><L><A><L><V><H><L><V><L><L><L><P><L><S><F><C><G><P><Q><K><L><N><H><F><F><C><E><I><M><A><V><L><K><L><A><C><A><D><T><H><I><N><E><V><M><V><L><A><G><A><V><S><V><L><V><G><A><F><F><S><T><V><I><S><Y><V><H><I><L><C><A><I><L><K><I><Q><S><G><E><G><C><Q><K><A><F><S><I><C><S><S><H><L><C><V><V><G><L><F><Y><G><T><A><I><I><M><Y><V><E><P><Q><Y><E><S><P><K><E><Q><K><K><Y><L><L><L><F><H><S><L><F><N><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><V><Q><G><T><L><K><R><M><L><E><K><K><R><T><S> | Odorant receptor.<BOP> | A4D2G3 |
Q8TDB6 | DTX3L_HUMAN | Rhysin-2 | Homo | <M><A><S><H><L><R><P><P><S><P><L><L><V><R><V><Y><K><S><G><P><R><V><R><R><K><L><E><S><Y><F><Q><S><S><K><S><S><G><G><G><E><C><T><V><S><T><Q><E><H><E><A><P><G><T><F><R><V><E><F><S><E><R><A><A><K><E><R><V><L><K><K><G><E><H><Q><I><L><V><D><E><K><P><V><P><I><F><L><V><P><T><E><N><S><I><K><K><N><T><R><P><Q><I><S><S><L><T><Q><S><Q><A><E><T><P><S><G><D><M><H><Q><H><E><G><H><I><P><N><A><V><D><S><C><L><Q><K><I><F><L><T><V><T><A><D><L><N><C><N><L><F><S><K><E><Q><R><A><Y><I><T><T><L><C><P><S><I><R><K><M><E><G><H><D><G><I><E><K><V><C><G><D><F><Q><D><I><E><R><I><H><Q><F><L><S><E><Q><F><L><E><S><E><Q><K><Q><Q><F><S><P><S><M><T><E><R><K><P><L><S><Q><Q><E><R><D><S><C><I><S><P><S><E><P><E><T><K><A><E><Q><K><S><N><Y><F><E><V><P><L><P><Y><F><E><Y><F><K><Y><I><C><P><D><K><I><N><S><I><E><K><R><F><G><V><N><I><E><I><Q><E><S><S><P><N><M><V><C><L><D><F><T><S><S><R><S><G><D><L><E><A><A><R><E><S><F><A><S><E><F><Q><K><N><T><E><P><L><K><Q><E><C><V><S><L><A><D><S><K><Q><A><N><K><F><K><Q><E><L><N><H><Q><F><T><K><L><L><I><K><E><K><G><G><E><L><T><L><L><G><T><Q><D><D><I><S><A><A><K><Q><K><I><S><E><A><F><V><K><I><P><V><K><L><F><A><A><N><Y><M><M><N><V><I><E><V><D><S><A><H><Y><K><L><L><E><T><E><L><L><Q><E><I><S><E><I><E><K><R><Y><D><I><C><S><K><V><S><E><K><G><Q><K><T><C><I><L><F><E><S><K><D><R><Q><V><D><L><S><V><H><A><Y><A><S><F><I><D><A><F><Q><H><A><S><C><Q><L><M><R><E><V><L><L><L><K><S><L><G><K><E><R><K><H><L><H><Q><T><K><F><A><D><D><F><R><K><R><H><P><N><V><H><F><V><L><N><Q><E><S><M><T><L><T><G><L><P><N><H><L><A><K><A><K><Q><Y><V><L><K><G><G><G><M><S><S><L><A><G><K><K><L><K><E><G><H><E><T><P><M><D><I><D><S><D><D><S><K><A><A><S><P><P><L><K><G><S><V><S><S><E><A><S><E><L><D><K><K><E><K><G><I><C><V><I><C><M><D><T><I><S><N><K><K><V><L><P><K><C><K><H><E><F><C><A><P><C><I><N><K><A><M><S><Y><K><P><I><C><P><T><C><Q><T><S><Y><G><I><Q><K><G><N><Q><P><E><G><S><M><V><F><T><V><S><R><D><S><L><P><G><Y><E><S><F><G><T><I><V><I><T><Y><S><M><K><A><G><I><Q><T><E><E><H><P><N><P><G><K><R><Y><P><G><I><Q><R><T><A><Y><L><P><D><N><K><E><G><R><K><V><L><K><L><L><Y><R><A><F><D><Q><K><L><I><F><T><V><G><Y><S><R><V><L><G><V><S><D><V><I><T><W><N><D><I><H><H><K><T><S><R><F><G><G><P><E><M><Y><G><Y><P><D><P><S><Y><L><K><R><V><K><E><E><L><K><A><K><G><I><E> | E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses . Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 . In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) . The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) . PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites . By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1 | Q8TDB6 |
Q86WU2 | LDHD_HUMAN | Probable D-lactate dehydrogenase, mitochondrial | Homo | <M><A><R><L><L><R><S><A><T><W><E><L><F><P><W><R><G><Y><C><S><Q><K><A><K><G><E><L><C><R><D><F><V><E><A><L><K><A><V><V><G><G><S><H><V><S><T><A><A><V><V><R><E><Q><H><G><R><D><E><S><V><H><R><C><E><P><P><D><A><V><V><W><P><Q><N><V><E><Q><V><S><R><L><A><A><L><C><Y><R><Q><G><V><P><I><I><P><F><G><T><G><T><G><L><E><G><G><V><C><A><V><Q><G><G><V><C><V><N><L><T><H><M><D><R><I><L><E><L><N><Q><E><D><F><S><V><V><V><E><P><G><V><T><R><K><A><L><N><A><H><L><R><D><S><G><L><W><F><P><V><D><P><G><A><D><A><S><L><C><G><M><A><A><T><G><A><S><G><T><N><A><V><R><Y><G><T><M><R><D><N><V><L><N><L><E><V><V><L><P><D><G><R><L><L><H><T><A><G><R><G><R><H><F><R><F><G><F><W><P><E><I><P><H><H><T><A><W><Y><S><P><C><V><S><L><G><R><R><K><S><A><A><G><Y><N><L><T><G><L><F><V><G><S><E><G><T><L><G><L><I><T><A><T><T><L><R><L><H><P><A><P><E><A><T><V><A><A><T><C><A><F><P><S><V><Q><A><A><V><D><S><T><V><H><I><L><Q><A><A><V><P><V><A><R><I><E><F><L><D><E><V><M><M><D><A><C><N><R><Y><S><K><L><N><C><L><V><A><P><T><L><F><L><E><F><H><G><S><Q><Q><A><L><E><E><Q><L><Q><R><T><E><E><I><V><Q><Q><N><G><A><S><D><F><S><W><A><K><E><A><E><E><R><S><R><L><W><T><A><R><H><N><A><W><Y><A><A><L><A><T><R><P><G><C><K><G><Y><S><T><D><V><C><V><P><I><S><R><L><P><E><I><V><V><Q><T><K><E><D><L><N><A><S><G><L><T><G><S><I><V><G><H><V><G><D><G><N><F><H><C><I><L><L><V><N><P><D><D><A><E><E><L><G><R><V><K><A><F><A><E><Q><L><G><R><R><A><L><A><L><H><G><T><C><T><G><E><H><G><I><G><M><G><K><R><Q><L><L><Q><E><E><V><G><A><V><G><V><E><T><M><R><Q><L><K><A><V><L><D><P><Q><G><L><M><N><P><G><K><V><L> | Involved in D-lactate, but not L-lactate catabolic process.<BOP> | Q86WU2 |
Q9H3H5 | GPT_HUMAN | N-acetylglucosamine-1-phosphate transferase | Homo | <M><W><A><F><S><E><L><P><M><P><L><L><I><N><L><I><V><S><L><L><G><F><V><A><T><V><T><L><I><P><A><F><R><G><H><F><I><A><A><R><L><C><G><Q><D><L><N><K><T><S><R><Q><Q><I><P><E><S><Q><G><V><I><S><G><A><V><F><L><I><I><L><F><C><F><I><P><F><P><F><L><N><C><F><V><K><E><Q><C><K><A><F><P><H><H><E><F><V><A><L><I><G><A><L><L><A><I><C><C><M><I><F><L><G><F><A><D><D><V><L><N><L><R><W><R><H><K><L><L><L><P><T><A><A><S><L><P><L><L><M><V><Y><F><T><N><F><G><N><T><T><I><V><V><P><K><P><F><R><P><I><L><G><L><H><L><D><L><G><I><L><Y><Y><V><Y><M><G><L><L><A><V><F><C><T><N><A><I><N><I><L><A><G><I><N><G><L><E><A><G><Q><S><L><V><I><S><A><S><I><I><V><F><N><L><V><E><L><E><G><D><C><R><D><D><H><V><F><S><L><Y><F><M><I><P><F><F><F><T><T><L><G><L><L><Y><H><N><W><Y><P><S><R><V><F><V><G><D><T><F><C><Y><F><A><G><M><T><F><A><V><V><G><I><L><G><H><F><S><K><T><M><L><L><F><F><M><P><Q><V><F><N><F><L><Y><S><L><P><Q><L><L><H><I><I><P><C><P><R><H><R><I><P><R><L><N><I><K><T><G><K><L><E><M><S><Y><S><K><F><K><T><K><S><L><S><F><L><G><T><F><I><L><K><V><A><E><S><L><Q><L><V><T><V><H><Q><S><E><T><E><D><G><E><F><T><E><C><N><N><M><T><L><I><N><L><L><L><K><V><L><G><P><I><H><E><R><N><L><T><L><L><L><L><L><L><Q><I><L><G><S><A><I><T><F><S><I><R><Y><Q><L><V><R><L><F><Y><D><V> | Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.<BOP> | Q9H3H5 |
O75530 | EED_HUMAN | WD protein associating with integrin cytoplasmic tails 1 | Homo | <M><S><E><R><E><V><S><T><A><P><A><G><T><D><M><P><A><A><K><K><Q><K><L><S><S><D><E><N><S><N><P><D><L><S><G><D><E><N><D><D><A><V><S><I><E><S><G><T><N><T><E><R><P><D><T><P><T><N><T><P><N><A><P><G><R><K><S><W><G><K><G><K><W><K><S><K><K><C><K><Y><S><F><K><C><V><N><S><L><K><E><D><H><N><Q><P><L><F><G><V><Q><F><N><W><H><S><K><E><G><D><P><L><V><F><A><T><V><G><S><N><R><V><T><L><Y><E><C><H><S><Q><G><E><I><R><L><L><Q><S><Y><V><D><A><D><A><D><E><N><F><Y><T><C><A><W><T><Y><D><S><N><T><S><H><P><L><L><A><V><A><G><S><R><G><I><I><R><I><I><N><P><I><T><M><Q><C><I><K><H><Y><V><G><H><G><N><A><I><N><E><L><K><F><H><P><R><D><P><N><L><L><L><S><V><S><K><D><H><A><L><R><L><W><N><I><Q><T><D><T><L><V><A><I><F><G><G><V><E><G><H><R><D><E><V><L><S><A><D><Y><D><L><L><G><E><K><I><M><S><C><G><M><D><H><S><L><K><L><W><R><I><N><S><K><R><M><M><N><A><I><K><E><S><Y><D><Y><N><P><N><K><T><N><R><P><F><I><S><Q><K><I><H><F><P><D><F><S><T><R><D><I><H><R><N><Y><V><D><C><V><R><W><L><G><D><L><I><L><S><K><S><C><E><N><A><I><V><C><W><K><P><G><K><M><E><D><D><I><D><K><I><K><P><S><E><S><N><V><T><I><L><G><R><F><D><Y><S><Q><C><D><I><W><Y><M><R><F><S><M><D><F><W><Q><K><M><L><A><L><G><N><Q><V><G><K><L><Y><V><W><D><L><E><V><E><D><P><H><K><A><K><C><T><T><L><T><H><H><K><C><G><A><A><I><R><Q><T><S><F><S><R><D><S><S><I><L><I><A><V><C><D><D><A><S><I><W><R><W><D><R><L><R> | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<BOP> | O75530 |
P09661 | RU2A_HUMAN | U2 small nuclear ribonucleoprotein A' | Homo | <M><V><K><L><T><A><E><L><I><E><Q><A><A><Q><Y><T><N><A><V><R><D><R><E><L><D><L><R><G><Y><K><I><P><V><I><E><N><L><G><A><T><L><D><Q><F><D><A><I><D><F><S><D><N><E><I><R><K><L><D><G><F><P><L><L><R><R><L><K><T><L><L><V><N><N><N><R><I><C><R><I><G><E><G><L><D><Q><A><L><P><C><L><T><E><L><I><L><T><N><N><S><L><V><E><L><G><D><L><D><P><L><A><S><L><K><S><L><T><Y><L><S><I><L><R><N><P><V><T><N><K><K><H><Y><R><L><Y><V><I><Y><K><V><P><Q><V><R><V><L><D><F><Q><K><V><K><L><K><E><R><Q><E><A><E><K><M><F><K><G><K><R><G><A><Q><L><A><K><D><I><A><R><R><S><K><T><F><N><P><G><A><G><L><P><T><D><K><K><K><G><G><P><S><P><G><D><V><E><A><I><K><N><A><I><A><N><A><S><T><L><A><E><V><E><R><L><K><G><L><L><Q><S><G><Q><I><P><G><R><E><R><R><S><G><P><T><D><D><G><E><E><E><M><E><E><D><T><V><T><N><G><S> | Involved in pre-mRNA splicing as component of the spliceosome . Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA .<BOP> | P09661 |
P19623 | SPEE_HUMAN | Putrescine aminopropyltransferase | Homo | <M><E><P><G><P><D><G><P><A><A><S><G><P><A><A><I><R><E><G><W><F><R><E><T><C><S><L><W><P><G><Q><A><L><S><L><Q><V><E><Q><L><L><H><H><R><R><S><R><Y><Q><D><I><L><V><F><R><S><K><T><Y><G><N><V><L><V><L><D><G><V><I><Q><C><T><E><R><D><E><F><S><Y><Q><E><M><I><A><N><L><P><L><C><S><H><P><N><P><R><K><V><L><I><I><G><G><G><D><G><G><V><L><R><E><V><V><K><H><P><S><V><E><S><V><V><Q><C><E><I><D><E><D><V><I><Q><V><S><K><K><F><L><P><G><M><A><I><G><Y><S><S><S><K><L><T><L><H><V><G><D><G><F><E><F><M><K><Q><N><Q><D><A><F><D><V><I><I><T><D><S><S><D><P><M><G><P><A><E><S><L><F><K><E><S><Y><Y><Q><L><M><K><T><A><L><K><E><D><G><V><L><C><C><Q><G><E><C><Q><W><L><H><L><D><L><I><K><E><M><R><Q><F><C><Q><S><L><F><P><V><V><A><Y><A><Y><C><T><I><P><T><Y><P><S><G><Q><I><G><F><M><L><C><S><K><N><P><S><T><N><F><Q><E><P><V><Q><P><L><T><Q><Q><Q><V><A><Q><M><Q><L><K><Y><Y><N><S><D><V><H><R><A><A><F><V><L><P><E><F><A><R><K><A><L><N><D><V><S> | Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.<BOP> | P19623 |
P35236 | PTN7_HUMAN | Protein-tyrosine phosphatase LC-PTP | Homo | <M><V><Q><A><H><G><G><R><S><R><A><Q><P><L><T><L><S><L><G><A><A><M><T><Q><P><P><P><E><K><T><P><A><K><K><H><V><R><L><Q><E><R><R><G><S><N><V><A><L><M><L><D><V><R><S><L><G><A><V><E><P><I><C><S><V><N><T><P><R><E><V><T><L><H><F><L><R><T><A><G><H><P><L><T><R><W><A><L><Q><R><Q><P><P><S><P><K><Q><L><E><E><E><F><L><K><I><P><S><N><F><V><S><P><E><D><L><D><I><P><G><H><A><S><K><D><R><Y><K><T><I><L><P><N><P><Q><S><R><V><C><L><G><R><A><Q><S><Q><E><D><G><D><Y><I><N><A><N><Y><I><R><G><Y><D><G><K><E><K><V><Y><I><A><T><Q><G><P><M><P><N><T><V><S><D><F><W><E><M><V><W><Q><E><E><V><S><L><I><V><M><L><T><Q><L><R><E><G><K><E><K><C><V><H><Y><W><P><T><E><E><E><T><Y><G><P><F><Q><I><R><I><Q><D><M><K><E><C><P><E><Y><T><V><R><Q><L><T><I><Q><Y><Q><E><E><R><R><S><V><K><H><I><L><F><S><A><W><P><D><H><Q><T><P><E><S><A><G><P><L><L><R><L><V><A><E><V><E><E><S><P><E><T><A><A><H><P><G><P><I><V><V><H><C><S><A><G><I><G><R><T><G><C><F><I><A><T><R><I><G><C><Q><Q><L><K><A><R><G><E><V><D><I><L><G><I><V><C><Q><L><R><L><D><R><G><G><M><I><Q><T><A><E><Q><Y><Q><F><L><H><H><T><L><A><L><Y><A><G><Q><L><P><E><E><P><S><P> | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.<BOP> | P35236 |
Q96DC9 | OTUB2_HUMAN | Ubiquitin-specific-processing protease OTUB2 | Homo | <M><S><E><T><S><F><N><L><I><S><E><K><C><D><I><L><S><I><L><R><D><H><P><E><N><R><I><Y><R><R><K><I><E><E><L><S><K><R><F><T><A><I><R><K><T><K><G><D><G><N><C><F><Y><R><A><L><G><Y><S><Y><L><E><S><L><L><G><K><S><R><E><I><F><K><F><K><E><R><V><L><Q><T><P><N><D><L><L><A><A><G><F><E><E><H><K><F><R><N><F><F><N><A><F><Y><S><V><V><E><L><V><E><K><D><G><S><V><S><S><L><L><K><V><F><N><D><Q><S><A><S><D><H><I><V><Q><F><L><R><L><L><T><S><A><F><I><R><N><R><A><D><F><F><R><H><F><I><D><E><E><M><D><I><K><D><F><C><T><H><E><V><E><P><M><A><T><E><C><D><H><I><Q><I><T><A><L><S><Q><A><L><S><I><A><L><Q><V><E><Y><V><D><E><M><D><T><A><L><N><H><H><V><F><P><E><A><A><T><P><S><V><Y><L><L><Y><K><T><S><H><Y><N><I><L><Y><A><A><D><K><H> | Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<BOP> | Q96DC9 |
Q9NQ48 | LZTL1_HUMAN | Leucine zipper transcription factor-like protein 1 | Homo | <M><A><E><L><G><L><N><E><H><H><Q><N><E><V><I><N><Y><M><R><F><A><R><S><K><R><G><L><R><L><K><T><V><D><S><C><F><Q><D><L><K><E><S><R><L><V><E><D><T><F><T><I><D><E><V><S><E><V><L><N><G><L><Q><A><V><V><H><S><E><V><E><S><E><L><I><N><T><A><Y><T><N><V><L><L><L><R><Q><L><F><A><Q><A><E><K><W><Y><L><K><L><Q><T><D><I><S><E><L><E><N><R><E><L><L><E><Q><V><A><E><F><E><K><A><E><I><T><S><S><N><K><K><P><I><L><D><V><T><K><P><K><L><A><P><L><N><E><G><G><T><A><E><L><L><N><K><E><I><L><R><L><Q><E><E><N><E><K><L><K><S><R><L><K><T><I><E><I><Q><A><T><N><A><L><D><E><K><S><K><L><E><K><A><L><Q><D><L><Q><L><D><Q><G><N><Q><K><D><F><I><K><A><Q><D><L><S><N><L><E><N><T><V><A><A><L><K><S><E><F><Q><K><T><L><N><D><K><T><E><N><Q><K><S><L><E><E><N><L><A><T><A><K><H><D><L><L><R><V><Q><E><Q><L><H><M><A><E><K><E><L><E><K><K><F><Q><Q><T><A><A><Y><R><N><M><K><E><I><L><T><K><K><N><D><Q><I><K><D><L><R><K><R><L><A><Q><Y><E><P><E><D> | Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.<BOP> | Q9NQ48 |
A0PJK1 | SC5AA_HUMAN | Solute carrier family 5 member 10 | Homo | <M><A><A><N><S><T><S><D><L><H><T><P><G><T><Q><L><S><V><A><D><I><I><V><I><T><V><Y><F><A><L><N><V><A><V><G><I><W><S><S><C><R><A><S><R><N><T><V><N><G><Y><F><L><A><G><R><D><M><T><W><W><P><I><G><A><S><L><F><A><S><S><E><G><S><G><L><F><I><G><L><A><G><S><G><A><A><G><G><L><A><V><A><G><F><E><W><N><A><T><Y><V><L><L><A><L><A><W><V><F><V><P><I><Y><I><S><S><E><I><V><T><L><P><E><Y><I><Q><K><R><Y><G><G><Q><R><I><R><M><Y><L><S><V><L><S><L><L><L><S><V><F><T><K><I><S><L><D><L><Y><A><G><A><L><F><V><H><I><C><L><G><W><N><F><Y><L><S><T><I><L><T><L><G><I><T><A><L><Y><T><I><A><G><G><L><A><A><V><I><Y><T><D><A><L><Q><T><L><I><M><V><V><G><A><V><I><L><T><I><K><A><F><D><Q><I><G><G><Y><G><Q><L><E><A><A><Y><A><Q><A><I><P><S><R><T><I><A><N><T><T><C><H><L><P><R><T><D><A><M><H><M><F><R><D><P><H><T><G><D><L><P><W><T><G><M><T><F><G><L><T><I><M><A><T><W><Y><W><C><T><D><Q><V><I><V><Q><R><S><L><S><A><R><D><L><N><H><A><K><A><G><S><I><L><A><S><Y><L><K><M><L><P><M><G><L><I><I><M><P><G><M><I><S><R><A><L><F><P><D><D><V><G><C><V><V><P><S><E><C><L><R><A><C><G><A><E><V><G><C><S><N><I><A><Y><P><K><L><V><M><E><L><M><P><I><G><L><R><G><L><M><I><A><V><M><L><A><A><L><M><S><S><L><T><S><I><F><N><S><S><S><T><L><F><T><M><D><I><W><R><R><L><R><P><R><S><G><E><R><E><L><L><L><V><G><R><L><V><I><V><A><L><I><G><V><S><V><A><W><I><P><V><L><Q><D><S><N><S><G><Q><L><F><I><Y><M><Q><S><V><T><S><S><L><A><P><P><V><T><A><V><F><V><L><G><V><F><W><R><R><A><N><E><Q><G><A><F><W><G><L><I><A><G><L><V><V><G><A><T><R><L><V><L><E><F><L><N><P><A><P><P><C><G><E><P><D><T><R><P><A><V><L><G><S><I><H><Y><L><H><F><A><V><A><L><F><A><L><S><G><A><V><V><V><A><G><S><L><L><T><P><P><P><Q><S><V><Q><I><E><N><L><T><W><W><T><L><A><Q><D><V><P><L><G><T><K><A><G><D><G><Q><T><P><Q><K><H><A><F><W><A><R><V><C><G><F><N><A><I><L><L><M><C><V><N><I><F><F><Y><A><Y><F><A> | High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.<BOP> | A0PJK1 |
Q96G46 | DUS3L_HUMAN | tRNA-dihydrouridine synthase 3-like | Homo | <M><A><E><G><T><A><E><A><P><L><E><N><G><G><G><G><D><S><G><A><G><A><L><E><R><G><V><A><P><I><K><R><Q><Y><L><T><T><K><E><Q><F><H><Q><F><L><E><A><K><G><Q><E><K><T><C><R><E><T><E><V><G><D><P><A><G><N><E><L><A><E><P><E><A><K><R><I><R><L><E><D><G><Q><T><A><D><G><Q><T><E><E><A><A><E><P><G><E><Q><L><Q><T><Q><K><R><A><R><G><Q><N><K><G><R><P><H><V><K><P><T><N><Y><D><K><N><R><L><C><P><S><L><I><Q><E><S><A><A><K><C><F><F><G><D><R><C><R><F><L><H><D><V><G><R><Y><L><E><T><K><P><A><D><L><G><P><R><C><V><L><F><E><T><F><G><R><C><P><Y><G><V><T><C><R><F><A><G><A><H><L><R><P><E><G><Q><N><L><V><Q><E><E><L><A><A><R><G><T><Q><P><P><S><I><R><N><G><L><D><K><A><L><Q><Q><Q><L><R><K><R><E><V><R><F><E><R><A><E><Q><A><L><R><R><F><S><Q><G><P><T><P><A><A><A><V><P><E><G><T><A><A><E><G><A><P><R><Q><E><N><C><G><A><Q><Q><V><P><A><G><P><G><T><S><T><P><P><S><S><P><V><R><T><C><G><P><L><T><D><E><D><V><V><R><L><R><P><C><E><K><K><R><L><D><I><R><G><K><L><Y><L><A><P><L><T><T><C><G><N><L><P><F><R><R><I><C><K><R><F><G><A><D><V><T><C><G><E><M><A><V><C><T><N><L><L><Q><G><Q><M><S><E><W><A><L><L><K><R><H><Q><C><E><D><I><F><G><V><Q><L><E><G><A><F><P><D><T><M><T><K><C><A><E><L><L><S><R><T><V><E><V><D><F><V><D><I><N><V><G><C><P><I><D><L><V><Y><K><K><G><G><G><C><A><L><M><N><R><S><T><K><F><Q><Q><I><V><R><G><M><N><Q><V><L><D><V><P><L><T><V><K><I><R><T><G><V><Q><E><R><V><N><L><A><H><R><L><L><P><E><L><R><D><W><G><V><A><L><V><T><L><H><G><R><S><R><E><Q><R><Y><T><K><L><A><D><W><Q><Y><I><E><E><C><V><Q><A><A><S><P><M><P><L><F><G><N><G><D><I><L><S><F><E><D><A><N><R><A><M><Q><T><G><V><T><G><I><M><I><A><R><G><A><L><L><K><P><W><L><F><T><E><I><K><E><Q><R><H><W><D><I><S><S><S><E><R><L><D><I><L><R><D><F><T><N><Y><G><L><E><H><W><G><S><D><T><Q><G><V><E><K><T><R><R><F><L><L><E><W><L><S><F><L><C><R><Y><V><P><V><G><L><L><E><R><L><P><Q><R><I><N><E><R><P><P><Y><Y><L><G><R><D><Y><L><E><T><L><M><A><S><Q><K><A><A><D><W><I><R><I><S><E><M><L><L><G><P><V><P><P><S><F><A><F><L><P><K><H><K><A><N><A><Y><K> | Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) . Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs . Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation .<BOP> | Q96G46 |
O14815 | CAN9_HUMAN | Protein CG36 | Homo | <M><P><Y><L><Y><R><A><P><G><P><Q><A><H><P><V><P><K><D><A><R><I><T><H><S><S><G><Q><S><F><E><Q><M><R><Q><E><C><L><Q><R><G><T><L><F><E><D><A><D><F><P><A><S><N><S><S><L><F><Y><S><E><R><P><Q><I><P><F><V><W><K><R><P><G><E><I><V><K><N><P><E><F><I><L><G><G><A><T><R><T><D><I><C><Q><G><E><L><G><D><C><W><L><L><A><A><I><A><S><L><T><L><N><Q><K><A><L><A><R><V><I><P><Q><D><Q><S><F><G><P><G><Y><A><G><I><F><H><F><Q><F><W><Q><H><S><E><W><L><D><V><V><I><D><D><R><L><P><T><F><R><D><R><L><V><F><L><H><S><A><D><H><N><E><F><W><S><A><L><L><E><K><A><Y><A><K><L><N><G><S><Y><E><A><L><K><G><G><S><A><I><E><A><M><E><D><F><T><G><G><V><A><E><T><F><Q><T><K><E><A><P><E><N><F><Y><E><I><L><E><K><A><L><K><R><G><S><L><L><G><C><F><I><D><T><R><S><A><A><E><S><E><A><R><T><P><F><G><L><I><K><G><H><A><Y><S><V><T><G><I><D><Q><V><S><F><R><G><Q><R><I><E><L><I><R><I><R><N><P><W><G><Q><V><E><W><N><G><S><W><S><D><S><S><P><E><W><R><S><V><G><P><A><E><Q><K><R><L><C><H><T><A><L><D><D><G><E><F><W><M><A><F><K><D><F><K><A><H><F><D><K><V><E><I><C><N><L><T><P><D><A><L><E><E><D><A><I><H><K><W><E><V><T><V><H><Q><G><S><W><V><R><G><S><T><A><G><G><C><R><N><F><L><D><T><F><W><T><N><P><Q><I><K><L><S><L><T><E><K><D><E><G><Q><E><E><C><S><F><L><V><A><L><M><Q><K><D><R><R><K><L><K><R><F><G><A><N><V><L><T><I><G><Y><A><I><Y><E><C><P><D><K><D><E><H><L><N><K><D><F><F><R><Y><H><A><S><R><A><R><S><K><T><F><I><N><L><R><E><V><S><D><R><F><K><L><P><P><G><E><Y><I><L><I><P><S><T><F><E><P><H><Q><E><A><D><F><C><L><R><I><F><S><E><K><K><A><I><T><R><D><M><D><G><N><V><D><I><D><L><P><E><P><P><K><P><T><P><P><D><Q><E><T><E><E><E><Q><R><F><R><A><L><F><E><Q><V><A><G><E><D><M><E><V><T><A><E><E><L><E><Y><V><L><N><A><V><L><Q><K><K><K><D><I><K><F><K><K><L><S><L><I><S><C><K><N><I><I><S><L><M><D><T><S><G><N><G><K><L><E><F><D><E><F><K><V><F><W><D><K><L><K><Q><W><I><N><L><F><L><R><F><D><A><D><K><S><G><T><M><S><T><Y><E><L><R><T><A><L><K><A><A><G><F><Q><L><S><S><H><L><L><Q><L><I><V><L><R><Y><A><D><E><E><L><Q><L><D><F><D><D><F><L><N><C><L><V><R><L><E><N><A><S><R><V><F><Q><A><L><S><T><K><N><K><E><F><I><H><L><N><I><N><E><F><I><H><L><T><M><N><I> | Calcium-regulated non-lysosomal thiol-protease.<BOP> | O14815 |
Q9NQH7 | XPP3_HUMAN | Aminopeptidase P3 | Homo | <M><P><W><L><L><S><A><P><K><L><V><P><A><V><A><N><V><R><G><L><S><G><C><M><L><C><S><Q><R><R><Y><S><L><Q><P><V><P><E><R><R><I><P><N><R><Y><L><G><Q><P><S><P><F><T><H><P><H><L><L><R><P><G><E><V><T><P><G><L><S><Q><V><E><Y><A><L><R><R><H><K><L><M><S><L><I><Q><K><E><A><Q><G><Q><S><G><T><D><Q><T><V><V><V><L><S><N><P><T><Y><Y><M><S><N><D><I><P><Y><T><F><H><Q><D><N><N><F><L><Y><L><C><G><F><Q><E><P><D><S><I><L><V><L><Q><S><L><P><G><K><Q><L><P><S><H><K><A><I><L><F><V><P><R><R><D><P><S><R><E><L><W><D><G><P><R><S><G><T><D><G><A><I><A><L><T><G><V><D><E><A><Y><T><L><E><E><F><Q><H><L><L><P><K><M><K><A><E><T><N><M><V><W><Y><D><W><M><R><P><S><H><A><Q><L><H><S><D><Y><M><Q><P><L><T><E><A><K><A><K><S><K><N><K><V><R><G><V><Q><Q><L><I><Q><R><L><R><L><I><K><S><P><A><E><I><E><R><M><Q><I><A><G><K><L><T><S><Q><A><F><I><E><T><M><F><T><S><K><A><P><V><E><E><A><F><L><Y><A><K><F><E><F><E><C><R><A><R><G><A><D><I><L><A><Y><P><P><V><V><A><G><G><N><R><S><N><T><L><H><Y><V><K><N><N><Q><L><I><K><D><G><E><M><V><L><L><D><G><G><C><E><S><S><C><Y><V><S><D><I><T><R><T><W><P><V><N><G><R><F><T><A><P><Q><A><E><L><Y><E><A><V><L><E><I><Q><R><D><C><L><A><L><C><F><P><G><T><S><L><E><N><I><Y><S><M><M><L><T><L><I><G><Q><K><L><K><D><L><G><I><M><K><N><I><K><E><N><N><A><F><K><A><A><R><K><Y><C><P><H><H><V><G><H><Y><L><G><M><D><V><H><D><T><P><D><M><P><R><S><L><P><L><Q><P><G><M><V><I><T><I><E><P><G><I><Y><I><P><E><D><D><K><D><A><P><E><K><F><R><G><L><G><V><R><I><E><D><D><V><V><V><T><Q><D><S><P><L><I><L><S><A><D><C><P><K><E><M><N><D><I><E><Q><I><C><S><Q><A><S> | Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.<BOP> | Q9NQH7 |
Q9H2Z4 | NKX24_HUMAN | Homeobox protein NK-2 homolog D | Homo | <M><S><L><S><P><K><H><T><T><P><F><S><V><S><D><I><L><S><P><I><E><E><T><Y><K><K><F><S><G><A><M><D><G><A><P><P><G><L><G><A><P><L><G><A><A><A><A><Y><R><A><P><P><P><G><P><S><S><Q><A><A><T><V><A><G><M><Q><P><S><H><A><M><A><G><H><N><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><T><Y><H><M><P><P><G><V><S><Q><F><P><H><G><A><M><G><S><Y><C><N><G><G><L><G><N><M><G><E><L><P><A><Y><T><D><G><M><R><G><G><A><A><T><G><W><Y><G><A><N><P><D><P><R><Y><S><S><I><S><R><F><M><G><P><S><A><G><V><N><V><A><G><M><G><S><L><T><G><I><A><D><A><A><K><S><L><G><P><L><H><A><A><A><A><A><A><A><P><R><R><K><R><R><V><L><F><S><Q><A><Q><V><Y><E><L><E><R><R><F><K><Q><Q><K><Y><L><S><A><P><E><R><E><H><L><A><S><M><I><H><L><T><P><T><Q><V><K><I><W><F><Q><N><H><R><Y><K><M><K><R><Q><A><K><D><K><A><A><Q><Q><L><Q><Q><E><G><G><L><G><P><P><P><P><P><P><P><S><P><R><R><V><A><V><P><V><L><V><K><D><G><K><P><C><Q><N><G><A><S><T><P><T><P><G><Q><A><G><P><Q><P><P><A><P><T><P><A><P><E><L><E><E><L><S><P><S><P><P><A><L><H><G><P><G><G><G><L><A><A><L><D><A><A><A><G><E><Y><S><G><G><V><L><G><A><N><L><L><Y><G><R><T><W> | Probable transcription factor.<BOP> | Q9H2Z4 |
O43765 | SGTA_HUMAN | Vpu-binding protein | Homo | <M><D><N><K><K><R><L><A><Y><A><I><I><Q><F><L><H><D><Q><L><R><H><G><G><L><S><S><D><A><Q><E><S><L><E><V><A><I><Q><C><L><E><T><A><F><G><V><T><V><E><D><S><D><L><A><L><P><Q><T><L><P><E><I><F><E><A><A><A><T><G><K><E><M><P><Q><D><L><R><S><P><A><R><T><P><P><S><E><E><D><S><A><E><A><E><R><L><K><T><E><G><N><E><Q><M><K><V><E><N><F><E><A><A><V><H><F><Y><G><K><A><I><E><L><N><P><A><N><A><V><Y><F><C><N><R><A><A><A><Y><S><K><L><G><N><Y><A><G><A><V><Q><D><C><E><R><A><I><C><I><D><P><A><Y><S><K><A><Y><G><R><M><G><L><A><L><S><S><L><N><K><H><V><E><A><V><A><Y><Y><K><K><A><L><E><L><D><P><D><N><E><T><Y><K><S><N><L><K><I><A><E><L><K><L><R><E><A><P><S><P><T><G><G><V><G><S><F><D><I><A><G><L><L><N><N><P><G><F><M><S><M><A><S><N><L><M><N><N><P><Q><I><Q><Q><L><M><S><G><M><I><S><G><G><N><N><P><L><G><T><P><G><T><S><P><S><Q><N><D><L><A><S><L><I><Q><A><G><Q><Q><F><A><Q><Q><M><Q><Q><Q><N><P><E><L><I><E><Q><L><R><S><Q><I><R><S><R><T><P><S><A><S><N><D><D><Q><Q><E> | (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 .<BOP> | O43765 |
Q9UNH6 | SNX7_HUMAN | Sorting nexin-7 | Homo | <M><D><M><N><S><F><S><P><M><M><P><T><S><P><L><S><M><I><N><Q><I><K><F><E><D><E><P><D><L><K><D><L><F><I><T><V><D><E><P><E><S><H><V><T><T><I><E><T><F><I><T><Y><R><I><I><T><K><T><S><R><G><E><F><D><S><S><E><F><E><V><R><R><R><Y><Q><D><F><L><W><L><K><G><K><L><E><E><A><H><P><T><L><I><I><P><P><L><P><E><K><F><I><V><K><G><M><V><E><R><F><N><D><D><F><I><E><T><R><R><K><A><L><H><K><F><L><N><R><I><A><D><H><P><T><L><T><F><N><E><D><F><K><I><F><L><T><A><Q><A><W><E><L><S><S><H><K><K><Q><G><P><G><L><L><S><R><M><G><Q><T><V><R><A><V><A><S><S><M><R><G><V><K><N><R><P><E><E><F><M><E><M><N><N><F><I><E><L><F><S><Q><K><I><N><L><I><D><K><I><S><Q><R><I><Y><K><E><E><R><E><Y><F><D><E><M><K><E><Y><G><P><I><H><I><L><W><S><A><S><E><E><D><L><V><D><T><L><K><D><V><A><S><C><I><D><R><C><C><K><A><T><E><K><R><M><S><G><L><S><E><A><L><L><P><V><V><H><E><Y><V><L><Y><S><E><M><L><M><G><V><M><K><R><R><D><Q><I><Q><A><E><L><D><S><K><V><E><V><L><T><Y><K><K><A><D><T><D><L><L><P><E><E><I><G><K><L><E><D><K><V><E><C><A><N><N><A><L><K><A><D><W><E><R><W><K><Q><N><M><Q><N><D><I><K><L><A><F><T><D><M><A><E><E><N><I><H><Y><Y><E><Q><C><L><A><T><W><E><S><F><L><T><S><Q><T><N><L><H><L><E><E><A><S><E><D><K><P> | Involved in the regulation of endocytosis and in several stages of intracellular trafficking . Together with SNX4, involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A .<BOP> | Q9UNH6 |
Q9HCU8 | DPOD4_HUMAN | DNA polymerase delta subunit p12 | Homo | <M><G><R><K><R><L><I><T><D><S><Y><P><V><V><K><R><R><E><G><P><A><G><H><S><K><G><E><L><A><P><E><L><G><E><E><P><Q><P><R><D><E><E><E><A><E><L><E><L><L><R><Q><F><D><L><A><W><Q><Y><G><P><C><T><G><I><T><R><L><Q><R><W><C><R><A><K><Q><M><G><L><E><P><P><P><E><V><W><Q><V><L><K><T><H><P><G><D><P><R><F><Q><C><S><L><W><H><L><Y><P><L> | As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity . Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system . Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb . Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites . Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival .<BOP> | Q9HCU8 |
Q9UIF7 | MUTYH_HUMAN | MutY homolog | Homo | <M><T><P><L><V><S><R><L><S><R><L><W><A><I><M><R><K><P><R><A><A><V><G><S><G><H><R><K><Q><A><A><S><Q><E><G><R><Q><K><H><A><K><N><N><S><Q><A><K><P><S><A><C><D><G><M><I><A><E><C><P><G><A><P><A><G><L><A><R><Q><P><E><E><V><V><L><Q><A><S><V><S><S><Y><H><L><F><R><D><V><A><E><V><T><A><F><R><G><S><L><L><S><W><Y><D><Q><E><K><R><D><L><P><W><R><R><R><A><E><D><E><M><D><L><D><R><R><A><Y><A><V><W><V><S><E><V><M><L><Q><Q><T><Q><V><A><T><V><I><N><Y><Y><T><G><W><M><Q><K><W><P><T><L><Q><D><L><A><S><A><S><L><E><E><V><N><Q><L><W><A><G><L><G><Y><Y><S><R><G><R><R><L><Q><E><G><A><R><K><V><V><E><E><L><G><G><H><M><P><R><T><A><E><T><L><Q><Q><L><L><P><G><V><G><R><Y><T><A><G><A><I><A><S><I><A><F><G><Q><A><T><G><V><V><D><G><N><V><A><R><V><L><C><R><V><R><A><I><G><A><D><P><S><S><T><L><V><S><Q><Q><L><W><G><L><A><Q><Q><L><V><D><P><A><R><P><G><D><F><N><Q><A><A><M><E><L><G><A><T><V><C><T><P><Q><R><P><L><C><S><Q><C><P><V><E><S><L><C><R><A><R><Q><R><V><E><Q><E><Q><L><L><A><S><G><S><L><S><G><S><P><D><V><E><E><C><A><P><N><T><G><Q><C><H><L><C><L><P><P><S><E><P><W><D><Q><T><L><G><V><V><N><F><P><R><K><A><S><R><K><P><P><R><E><E><S><S><A><T><C><V><L><E><Q><P><G><A><L><G><A><Q><I><L><L><V><Q><R><P><N><S><G><L><L><A><G><L><W><E><F><P><S><V><T><W><E><P><S><E><Q><L><Q><R><K><A><L><L><Q><E><L><Q><R><W><A><G><P><L><P><A><T><H><L><R><H><L><G><E><V><V><H><T><F><S><H><I><K><L><T><Y><Q><V><Y><G><L><A><L><E><G><Q><T><P><V><T><T><V><P><P><G><A><R><W><L><T><Q><E><E><F><H><T><A><A><V><S><T><A><M><K><K><V><F><R><V><Y><Q><G><Q><Q><P><G><T><C><M><G><S><K><R><S><Q><V><S><S><P><C><S><R><K><K><P><R><M><G><Q><Q><V><L><D><N><F><F><R><S><H><I><S><T><D><A><H><S><L><N><S><A><A><Q> | Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.<BOP> | Q9UIF7 |
Q96MF6 | CQ10A_HUMAN | Coenzyme Q-binding protein COQ10 homolog A, mitochondrial | Homo | <M><A><W><A><G><S><R><R><V><P><A><G><T><R><A><A><A><E><R><C><C><R><L><S><L><S><P><G><A><Q><P><A><P><P><P><G><P><L><P><P><P><R><P><M><R><F><L><T><S><C><S><L><L><L><P><R><A><A><Q><I><L><A><A><E><A><G><L><P><S><S><R><S><F><M><G><F><A><A><P><F><T><N><K><R><K><A><Y><S><E><R><R><I><M><G><Y><S><M><Q><E><M><Y><E><V><V><S><N><V><Q><E><Y><R><E><F><V><P><W><C><K><K><S><L><V><V><S><S><R><K><G><H><L><K><A><Q><L><E><V><G><F><P><P><V><M><E><R><Y><T><S><A><V><S><M><V><K><P><H><M><V><K><A><V><C><T><D><G><K><L><F><N><H><L><E><T><I><W><R><F><S><P><G><I><P><A><Y><P><R><T><C><T><V><D><F><S><I><S><F><E><F><R><S><L><L><H><S><Q><L><A><T><M><F><F><D><E><V><V><K><Q><N><V><A><A><F><E><R><R><A><A><T><K><F><G><P><E><T><A><I><P><R><E><L><M><F><H><E><V><H><Q><T> | Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).<BOP> | Q96MF6 |
Q96RB7 | OR5MB_HUMAN | Olfactory receptor 5M11 | Homo | <M><S><N><T><N><G><S><A><I><T><E><F><I><L><L><G><L><T><D><C><P><E><L><Q><S><L><L><F><V><L><F><L><V><V><Y><L><V><T><L><L><G><N><L><G><M><I><M><L><M><R><L><D><S><R><L><H><T><P><M><Y><F><F><L><T><N><L><A><F><V><D><L><C><Y><T><S><N><A><T><P><Q><M><S><T><N><I><V><S><E><K><T><I><S><F><A><G><C><F><T><Q><C><Y><I><F><I><A><L><L><L><T><E><F><Y><M><L><A><A><M><A><Y><D><R><Y><V><A><I><Y><D><P><L><R><Y><S><V><K><T><S><R><R><V><C><I><C><L><A><T><F><P><Y><V><Y><G><F><S><D><G><L><F><Q><A><I><L><T><F><R><L><T><F><C><R><S><S><V><I><N><H><F><Y><C><A><D><P><P><L><I><K><L><S><C><S><D><T><Y><V><K><E><H><A><M><F><I><S><A><G><F><N><L><S><S><S><L><T><I><V><L><V><S><Y><A><F><I><L><A><A><I><L><R><I><K><S><A><E><G><R><H><K><A><F><S><T><C><G><S><H><M><M><A><V><T><L><F><Y><G><T><L><F><C><M><Y><I><R><P><P><T><D><K><T><V><E><E><S><K><I><I><A><V><F><Y><T><F><V><S><P><V><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><Q><A><L><K><N><V><L><R> | Odorant receptor.<BOP> | Q96RB7 |
O60516 | 4EBP3_HUMAN | Eukaryotic translation initiation factor 4E-binding protein 3 | Homo | <M><S><T><S><T><S><C><P><I><P><G><G><R><D><Q><L><P><D><C><Y><S><T><T><P><G><G><T><L><Y><A><T><T><P><G><G><T><R><I><I><Y><D><R><K><F><L><L><E><C><K><N><S><P><I><A><R><T><P><P><C><C><L><P><Q><I><P><G><V><T><T><P><P><T><A><P><L><S><K><L><E><E><L><K><E><Q><E><T><E><E><E><I><P><D><D><A><Q><F><E><M><D><I> | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.<BOP> | O60516 |
A0A1B0GX68 | TVB2_HUMAN | T cell receptor beta variable 2 | Homo | <M><D><T><W><L><V><C><W><A><I><F><S><L><L><K><A><G><L><T><E><P><E><V><T><Q><T><P><S><H><Q><V><T><Q><M><G><Q><E><V><I><L><R><C><V><P><I><S><N><H><L><Y><F><Y><W><Y><R><Q><I><L><G><Q><K><V><E><F><L><V><S><F><Y><N><N><E><I><S><E><K><S><E><I><F><D><D><Q><F><S><V><E><R><P><D><G><S><N><F><T><L><K><I><R><S><T><K><L><E><D><S><A><M><Y><F><C><A><S><S><E> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A1B0GX68 |
Q8WXU2 | DAAF4_HUMAN | Dyslexia susceptibility 1 candidate gene 1 protein | Homo | <M><P><L><Q><V><S><D><Y><S><W><Q><Q><T><K><T><A><V><F><L><S><L><P><L><K><G><V><C><V><R><D><T><D><V><F><C><T><E><N><Y><L><K><V><N><F><P><P><F><L><F><E><A><F><L><Y><A><P><I><D><D><E><S><S><K><A><K><I><G><N><D><T><I><V><F><T><L><Y><K><K><E><A><A><M><W><E><T><L><S><V><T><G><V><D><K><E><M><M><Q><R><I><R><E><K><S><I><L><Q><A><Q><E><R><A><K><E><A><T><E><A><K><A><A><A><K><R><E><D><Q><K><Y><A><L><S><V><M><M><K><I><E><E><E><E><R><K><K><I><E><D><M><K><E><N><E><R><I><K><A><T><K><A><L><E><A><W><K><E><Y><Q><R><K><A><E><E><Q><K><K><I><Q><R><E><E><K><L><C><Q><K><E><K><Q><I><K><E><E><R><K><K><I><K><Y><K><S><L><T><R><N><L><A><S><R><N><L><A><P><K><G><R><N><S><E><N><I><F><T><E><K><L><K><E><D><S><I><P><A><P><R><S><V><G><S><I><K><I><N><F><T><P><R><V><F><P><T><A><L><R><E><S><Q><V><A><E><E><E><E><W><L><H><K><Q><A><E><A><R><R><A><M><N><T><D><I><A><E><L><C><D><L><K><E><E><E><K><N><P><E><W><L><K><D><K><G><N><K><L><F><A><T><E><N><Y><L><A><A><I><N><A><Y><N><L><A><I><R><L><N><N><K><M><P><L><L><Y><L><N><R><A><A><C><H><L><K><L><K><N><L><H><K><A><I><E><D><S><S><K><A><L><E><L><L><M><P><P><V><T><D><N><A><N><A><R><M><K><A><H><V><R><R><G><T><A><F><C><Q><L><E><L><Y><V><E><G><L><Q><D><Y><E><A><A><L><K><I><D><P><S><N><K><I><V><Q><I><D><A><E><K><I><R><N><V><I><Q><G><T><E><L><K><S> | Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.<BOP> | Q8WXU2 |
Q96I27 | ZN625_HUMAN | Zinc finger protein 625 | Homo | <M><G><E><R><L><L><E><S><K><K><D><H><Q><H><G><E><I><L><T><Q><V><P><D><D><M><L><K><K><K><T><P><R><V><K><S><C><G><E><V><S><V><G><H><A><S><L><N><R><H><H><R><A><D><T><G><H><K><P><Y><E><Y><Q><E><Y><G><Q><K><P><Y><K><C><T><Y><C><K><K><A><F><S><D><L><P><Y><F><R><T><H><E><W><A><H><T><G><G><K><P><Y><D><C><E><E><C><G><K><S><F><I><S><R><S><S><I><R><R><H><R><I><M><H><S><G><D><G><P><Y><K><C><N><F><C><G><K><A><L><M><C><L><S><L><Y><L><I><H><K><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><H><S><G><S><L><R><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><H><S><S><T><C><L><H><A><H><K><I><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><V><S><F><N><S><V><R><Y><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><A><S><H><L><R><T><H><G><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><G><C><A><S><S><V><K><I><H><E><R><T><H><T><G><E><K><P><C><S><S><N><T><S><K><G><Q><G><E><K><I><A> | May be involved in transcriptional regulation.<BOP> | Q96I27 |
P56134 | ATPK_HUMAN | ATP synthase membrane subunit f | Homo | <M><A><S><V><G><E><C><P><A><P><V><P><V><K><D><K><K><L><L><E><V><K><L><G><E><L><P><S><W><I><L><M><R><D><F><S><P><S><G><I><F><G><A><F><Q><R><G><Y><Y><R><Y><Y><N><K><Y><I><N><V><K><K><G><S><I><S><G><I><T><M><V><L><A><C><Y><V><L><F><S><Y><S><F><S><Y><K><H><L><K><H><E><R><L><R><K><Y><H> | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.<BOP> | P56134 |
Q6ISU1 | PTCRA_HUMAN | pT-alpha-TCR | Homo | <M><A><G><T><W><L><L><L><L><L><A><L><G><C><P><A><L><P><T><G><V><G><G><T><P><F><P><S><L><A><P><P><I><M><L><L><V><D><G><K><Q><Q><M><V><V><V><C><L><V><L><D><V><A><P><P><G><L><D><S><P><I><W><F><S><A><G><N><G><S><A><L><D><A><F><T><Y><G><P><S><P><A><T><D><G><T><W><T><N><L><A><H><L><S><L><P><S><E><E><L><A><S><W><E><P><L><V><C><H><T><G><P><G><A><E><G><H><S><R><S><T><Q><P><M><H><L><S><G><E><A><S><T><A><R><T><C><P><Q><E><P><L><R><G><T><P><G><G><A><L><W><L><G><V><L><R><L><L><L><F><K><L><L><L><F><D><L><L><L><T><C><S><C><L><C><D><P><A><G><P><L><P><S><P><A><T><T><T><R><L><R><A><L><G><S><H><R><L><H><P><A><T><E><T><G><G><R><E><A><T><S><S><P><R><P><Q><P><R><D><R><R><W><G><D><T><P><P><G><R><K><P><G><S><P><V><W><G><E><G><S><Y><L><S><S><Y><P><T><C><P><A><Q><A><W><C><S><R><S><A><L><R><A><P><S><S><S><L><G><A><F><F><A><G><D><L><P><P><P><L><Q><A><G><A><A> | The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.<BOP> | Q6ISU1 |
O76080 | ZFAN5_HUMAN | Zinc finger protein 216 | Homo | <M><A><Q><E><T><N><Q><T><P><G><P><M><L><C><S><T><G><C><G><F><Y><G><N><P><R><T><N><G><M><C><S><V><C><Y><K><E><H><L><Q><R><Q><Q><N><S><G><R><M><S><P><M><G><T><A><S><G><S><N><S><P><T><S><D><S><A><S><V><Q><R><A><D><T><S><L><N><N><C><E><G><A><A><G><S><T><S><E><K><S><R><N><V><P><V><A><A><L><P><V><T><Q><Q><M><T><E><M><S><I><S><R><E><D><K><I><T><T><P><K><T><E><V><S><E><P><V><V><T><Q><P><S><P><S><V><S><Q><P><S><T><S><Q><S><E><E><K><A><P><E><L><P><K><P><K><K><N><R><C><F><M><C><R><K><K><V><G><L><T><G><F><D><C><R><C><G><N><L><F><C><G><L><H><R><Y><S><D><K><H><N><C><P><Y><D><Y><K><A><E><A><A><A><K><I><R><K><E><N><P><V><V><V><A><E><K><I><Q><R><I> | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.<BOP> | O76080 |
Q9NS00 | C1GLT_HUMAN | Core 1 beta1,3-galactosyltransferase 1 | Homo | <M><A><S><K><S><W><L><N><F><L><T><F><L><C><G><S><A><I><G><F><L><L><C><S><Q><L><F><S><I><L><L><G><E><K><V><D><T><Q><P><N><V><L><H><N><D><P><H><A><R><H><S><D><D><N><G><Q><N><H><L><E><G><Q><M><N><F><N><A><D><S><S><Q><H><K><D><E><N><T><D><I><A><E><N><L><Y><Q><K><V><R><I><L><C><W><V><M><T><G><P><Q><N><L><E><K><K><A><K><H><V><K><A><T><W><A><Q><R><C><N><K><V><L><F><M><S><S><E><E><N><K><D><F><P><A><V><G><L><K><T><K><E><G><R><D><Q><L><Y><W><K><T><I><K><A><F><Q><Y><V><H><E><H><Y><L><E><D><A><D><W><F><L><K><A><D><D><D><T><Y><V><I><L><D><N><L><R><W><L><L><S><K><Y><D><P><E><E><P><I><Y><F><G><R><R><F><K><P><Y><V><K><Q><G><Y><M><S><G><G><A><G><Y><V><L><S><K><E><A><L><K><R><F><V><D><A><F><K><T><D><K><C><T><H><S><S><S><I><E><D><L><A><L><G><R><C><M><E><I><M><N><V><E><A><G><D><S><R><D><T><I><G><K><E><T><F><H><P><F><V><P><E><H><H><L><I><K><G><Y><L><P><R><T><F><W><Y><W><N><Y><N><Y><Y><P><P><V><E><G><P><G><C><C><S><D><L><A><V><S><F><H><Y><V><D><S><T><T><M><Y><E><L><E><Y><L><V><Y><H><L><R><P><Y><G><Y><L><Y><R><Y><Q><P><T><L><P><E><R><I><L><K><E><I><S><Q><A><N><K><N><E><D><T><K><V><K><L><G><N><P> | Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.<BOP> | Q9NS00 |
Q8WWY8 | LIPH_HUMAN | Phospholipase A1 member B | Homo | <M><L><R><F><Y><L><F><I><S><L><L><C><L><S><R><S><D><A><E><E><T><C><P><S><F><T><R><L><S><F><H><S><A><V><V><G><T><G><L><N><V><R><L><M><L><Y><T><R><K><N><L><T><C><A><Q><T><I><N><S><S><A><F><G><N><L><N><V><T><K><K><T><T><F><I><V><H><G><F><R><P><T><G><S><P><P><V><W><M><D><D><L><V><K><G><L><L><S><V><E><D><M><N><V><V><V><V><D><W><N><R><G><A><T><T><L><I><Y><T><H><A><S><S><K><T><R><K><V><A><M><V><L><K><E><F><I><D><Q><M><L><A><E><G><A><S><L><D><D><I><Y><M><I><G><V><S><L><G><A><H><I><S><G><F><V><G><E><M><Y><D><G><W><L><G><R><I><T><G><L><D><P><A><G><P><L><F><N><G><K><P><H><Q><D><R><L><D><P><S><D><A><Q><F><V><D><V><I><H><S><D><T><D><A><L><G><Y><K><E><P><L><G><N><I><D><F><Y><P><N><G><G><L><D><Q><P><G><C><P><K><T><I><L><G><G><F><Q><Y><F><K><C><D><H><Q><R><S><V><Y><L><Y><L><S><S><L><R><E><S><C><T><I><T><A><Y><P><C><D><S><Y><Q><D><Y><R><N><G><K><C><V><S><C><G><T><S><Q><K><E><S><C><P><L><L><G><Y><Y><A><D><N><W><K><D><H><L><R><G><K><D><P><P><M><T><K><A><F><F><D><T><A><E><E><S><P><F><C><M><Y><H><Y><F><V><D><I><I><T><W><N><K><N><V><R><R><G><D><I><T><I><K><L><R><D><K><A><G><N><T><T><E><S><K><I><N><H><E><P><T><T><F><Q><K><Y><H><Q><V><S><L><L><A><R><F><N><Q><D><L><D><K><V><A><A><I><S><L><M><F><S><T><G><S><L><I><G><P><R><Y><K><L><R><I><L><R><M><K><L><R><S><L><A><H><P><E><R><P><Q><L><C><R><Y><D><L><V><L><M><E><N><V><E><T><V><F><Q><P><I><L><C><P><E><L><Q><L> | Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).<BOP> | Q8WWY8 |
Q7Z602 | GP141_HUMAN | G-protein coupled receptor PGR13 | Homo | <M><P><G><H><N><T><S><R><N><S><S><C><D><P><I><V><T><P><H><L><I><S><L><Y><F><I><V><L><I><G><G><L><V><G><V><I><S><I><L><F><L><L><V><K><M><N><T><R><S><V><T><T><M><A><V><I><N><L><V><V><V><H><S><V><F><L><L><T><V><P><F><R><L><T><Y><L><I><K><K><T><W><M><F><G><L><P><F><C><K><F><V><S><A><M><L><H><I><H><M><Y><L><T><F><L><F><Y><V><V><I><L><V><T><R><Y><L><I><F><F><K><C><K><D><K><V><E><F><Y><R><K><L><H><A><V><A><A><S><A><G><M><W><T><L><V><I><V><I><V><V><P><L><V><V><S><R><Y><G><I><H><E><E><Y><N><E><E><H><C><F><K><F><H><K><E><L><A><Y><T><Y><V><K><I><I><N><Y><M><I><V><I><F><V><I><A><V><A><V><I><L><L><V><F><Q><V><F><I><I><M><L><M><V><Q><K><L><R><H><S><L><L><S><H><Q><E><F><W><A><Q><L><K><N><L><F><F><I><G><V><I><L><V><C><F><L><P><Y><Q><F><F><R><I><Y><Y><L><N><V><V><T><H><S><N><A><C><N><S><K><V><A><F><Y><N><E><I><F><L><S><V><T><A><I><S><C><Y><D><L><L><L><F><V><F><G><G><S><H><W><F><K><Q><K><I><I><G><L><W><N><C><V><L><C><R> | Orphan receptor.<BOP> | Q7Z602 |
Q969X1 | LFG3_HUMAN | Transmembrane BAX inhibitor motif-containing protein 1 | Homo | <M><S><N><P><S><A><P><P><P><Y><E><D><R><N><P><L><Y><P><G><P><P><P><P><G><G><Y><G><Q><P><S><V><L><P><G><G><Y><P><A><Y><P><G><Y><P><Q><P><G><Y><G><H><P><A><G><Y><P><Q><P><M><P><P><T><H><P><M><P><M><N><Y><G><P><G><H><G><Y><D><G><E><E><R><A><V><S><D><S><F><G><P><G><E><W><D><D><R><K><V><R><H><T><F><I><R><K><V><Y><S><I><I><S><V><Q><L><L><I><T><V><A><I><I><A><I><F><T><F><V><E><P><V><S><A><F><V><R><R><N><V><A><V><Y><Y><V><S><Y><A><V><F><V><V><T><Y><L><I><L><A><C><C><Q><G><P><R><R><R><F><P><W><N><I><I><L><L><T><L><F><T><F><A><M><G><F><M><T><G><T><I><S><S><M><Y><Q><T><K><A><V><I><I><A><M><I><I><T><A><V><V><S><I><S><V><T><I><F><C><F><Q><T><K><V><D><F><T><S><C><T><G><L><F><C><V><L><G><I><V><L><L><V><T><G><I><V><T><S><I><V><L><Y><F><Q><Y><V><Y><W><L><H><M><L><Y><A><A><L><G><A><I><C><F><T><L><F><L><A><Y><D><T><Q><L><V><L><G><N><R><K><H><T><I><S><P><E><D><Y><I><T><G><A><L><Q><I><Y><T><D><I><I><Y><I><F><T><F><V><L><Q><L><M><G><D><R><N> | Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.<BOP> | Q969X1 |
P01282 | VIP_HUMAN | Vasoactive intestinal polypeptide | Homo | <M><D><T><R><N><K><A><Q><L><L><V><L><L><T><L><L><S><V><L><F><S><Q><T><S><A><W><P><L><Y><R><A><P><S><A><L><R><L><G><D><R><I><P><F><E><G><A><N><E><P><D><Q><V><S><L><K><E><D><I><D><M><L><Q><N><A><L><A><E><N><D><T><P><Y><Y><D><V><S><R><N><A><R><H><A><D><G><V><F><T><S><D><F><S><K><L><L><G><Q><L><S><A><K><K><Y><L><E><S><L><M><G><K><R><V><S><S><N><I><S><E><D><P><V><P><V><K><R><H><S><D><A><V><F><T><D><N><Y><T><R><L><R><K><Q><M><A><V><K><K><Y><L><N><S><I><L><N><G><K><R><S><S><E><G><E><S><P><D><F><P><E><E><L><E><K> | PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.<BOP> | P01282 |
Q8N5U1 | M4A15_HUMAN | Membrane-spanning 4-domains subfamily A member 15 | Homo | <M><S><A><A><P><A><S><N><G><V><F><V><V><I><P><P><N><N><A><S><G><L><C><P><P><P><A><I><L><P><T><S><M><C><Q><P><P><G><I><M><Q><F><E><E><P><P><L><G><A><Q><T><P><R><A><T><Q><P><P><D><L><R><P><V><E><T><F><L><T><G><E><P><K><V><L><G><T><V><Q><I><L><I><G><L><I><H><L><G><F><G><S><V><L><L><M><V><R><R><G><H><V><G><I><F><F><I><E><G><G><V><P><F><W><G><G><A><C><F><I><I><S><G><S><L><S><V><A><A><E><K><N><H><T><S><C><L><V><R><S><S><L><G><T><N><I><L><S><V><M><A><A><F><A><G><T><A><I><L><L><M><D><F><G><V><T><N><R><D><V><D><R><G><Y><L><A><V><L><T><I><F><T><V><L><E><F><F><T><A><V><I><A><M><H><F><G><C><Q><A><I><H><A><Q><A><S><A><P><V><I><F><L><P><N><A><F><S><A><D><F><N><I><P><S><P><A><A><S><A><P><P><A><Y><D><N><V><A><Y><A><Q><G><V><V> | May be involved in signal transduction as a component of a multimeric receptor complex.<BOP> | Q8N5U1 |
Q16401 | PSMD5_HUMAN | 26S proteasome subunit S5B | Homo | <M><A><A><Q><A><L><A><L><L><R><E><V><A><R><L><E><A><P><L><E><E><L><R><A><L><H><S><V><L><Q><A><V><P><L><N><E><L><R><Q><Q><A><A><E><L><R><L><G><P><L><F><S><L><L><N><E><N><H><R><E><K><T><T><L><C><V><S><I><L><E><R><L><L><Q><A><M><E><P><V><H><V><A><R><N><L><R><V><D><L><Q><R><G><L><I><H><P><D><D><S><V><K><I><L><T><L><S><Q><I><G><R><I><V><E><N><S><D><A><V><T><E><I><L><N><N><A><E><L><L><K><Q><I><V><Y><C><I><G><G><E><N><L><S><V><A><K><A><A><I><K><S><L><S><R><I><S><L><T><Q><A><G><L><E><A><L><F><E><S><N><L><L><D><D><L><K><S><V><M><K><T><N><D><I><V><R><Y><R><V><Y><E><L><I><I><E><I><S><S><V><S><P><E><S><L><N><Y><C><T><T><S><G><L><V><T><Q><L><L><R><E><L><T><G><E><D><V><L><V><R><A><T><C><I><E><M><V><T><S><L><A><Y><T><H><H><G><R><Q><Y><L><A><Q><E><G><V><I><D><Q><I><S><N><I><I><V><G><A><D><S><D><P><F><S><S><F><Y><L><P><G><F><V><K><F><F><G><N><L><A><V><M><D><S><P><Q><Q><I><C><E><R><Y><P><I><F><V><E><K><V><F><E><M><I><E><S><Q><D><P><T><M><I><G><V><A><V><D><T><V><G><I><L><G><S><N><V><E><G><K><Q><V><L><Q><K><T><G><T><R><F><E><R><L><L><M><R><I><G><H><Q><S><K><N><A><P><V><E><L><K><I><R><C><L><D><A><I><S><S><L><L><Y><L><P><P><E><Q><Q><T><D><D><L><L><R><M><T><E><S><W><F><S><S><L><S><R><D><P><L><E><L><F><R><G><I><S><S><Q><P><F><P><E><L><H><C><A><A><L><K><V><F><T><A><I><A><N><Q><P><W><A><Q><K><L><M><F><N><S><P><G><F><V><E><Y><V><V><D><R><S><V><E><H><D><K><A><S><K><D><A><K><Y><E><L><V><K><A><L><A><N><S><K><T><I><A><E><I><F><G><N><P><N><Y><L><R><L><R><T><Y><L><S><E><G><P><Y><Y><V><K><P><V><S><T><T><A><V><E><G><A><E> | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.<BOP> | Q16401 |
P0DTE4 | UD2A1_HUMAN | UDP-glucuronosyltransferase 2A1 | Homo | <M><L><N><N><L><L><L><F><S><L><Q><I><S><L><I><G><T><T><L><G><G><N><V><L><I><W><P><M><E><G><S><H><W><L><N><V><K><I><I><I><D><E><L><I><K><K><E><H><N><V><T><V><L><V><A><S><G><A><L><F><I><T><P><T><S><N><P><S><L><T><F><E><I><Y><K><V><P><F><G><K><E><R><I><E><G><V><I><K><D><F><V><L><T><W><L><E><N><R><P><S><P><S><T><I><W><R><F><Y><Q><E><M><A><K><V><I><K><D><F><H><M><V><S><Q><E><I><C><D><G><V><L><K><N><Q><Q><L><M><A><K><L><K><K><S><K><F><E><V><L><V><S><D><P><V><F><P><C><G><D><I><V><A><L><K><L><G><I><P><F><M><Y><S><L><R><F><S><P><A><S><T><V><E><K><H><C><G><K><V><P><Y><P><P><S><Y><V><P><A><V><L><S><E><L><T><D><Q><M><S><F><T><D><R><I><R><N><F><I><S><Y><H><L><Q><D><Y><M><F><E><T><L><W><K><S><W><D><S><Y><Y><S><K><A><L><G><G><L><L><L><C><C><P><G><W><S><A><V><A><D><L><G><S><L><Q><P><L><L><P><G><F><K><R><F><S><R><L><S><L><H><C><S><W><D><Y><R><L><P><A><G><R><P><T><T><L><C><E><T><M><G><K><A><E><I><W><L><I><R><T><Y><W><D><F><E><F><P><R><P><Y><L><P><N><F><E><F><V><G><G><L><H><C><K><P><A><K><P><L><P><K><V><L><W><R><Y><K><G><K><K><P><A><T><L><G><N><N><T><Q><L><F><D><W><I><P><Q><N><D><L><L><G><H><P><K><T><K><A><F><I><T><H><G><G><T><N><G><I><Y><E><A><I><Y><H><G><V><P><M><V><G><V><P><M><F><A><D><Q><P><D><N><I><A><H><M><K><A><K><G><A><A><V><E><V><N><L><N><T><M><T><S><V><D><L><L><S><A><L><R><T><V><I><N><E><P><S><Y><K><E><N><A><M><R><L><S><R><I><H><H><D><Q><P><V><K><P><L><D><R><A><V><F><W><I><E><F><V><M><R><H><K><G><A><K><H><L><R><V><A><A><H><D><L><T><W><F><Q><Y><H><S><L><D><V><I><G><F><L><L><V><C><V><T><T><A><I><F><L><V><I><Q><C><C><L><F><S><C><Q><K><F><G><K><I><G><K><K><K><K><R><E> | UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol) . Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption . Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction . Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth .<BOP> | P0DTE4 |
Q8IUN9 | CLC10_HUMAN | Macrophage lectin 2 | Homo | <M><T><R><T><Y><E><N><F><Q><Y><L><E><N><K><V><K><V><Q><G><F><K><N><G><P><L><P><L><Q><S><L><L><Q><R><L><C><S><G><P><C><H><L><L><L><S><L><G><L><G><L><L><L><L><V><I><I><C><V><V><G><F><Q><N><S><K><F><Q><R><D><L><V><T><L><R><T><D><F><S><N><F><T><S><N><T><V><A><E><I><Q><A><L><T><S><Q><G><S><S><L><E><E><T><I><A><S><L><K><A><E><V><E><G><F><K><Q><E><R><Q><A><G><V><S><E><L><Q><E><H><T><T><Q><K><A><H><L><G><H><C><P><H><C><P><S><V><C><V><P><V><H><S><E><M><L><L><R><V><Q><Q><L><V><Q><D><L><K><K><L><T><C><Q><V><A><T><L><N><N><N><A><S><T><E><G><T><C><C><P><V><N><W><V><E><H><Q><D><S><C><Y><W><F><S><H><S><G><M><S><W><A><E><A><E><K><Y><C><Q><L><K><N><A><H><L><V><V><I><N><S><R><E><E><Q><N><F><V><Q><K><Y><L><G><S><A><Y><T><W><M><G><L><S><D><P><E><G><A><W><K><W><V><D><G><T><D><Y><A><T><G><F><Q><N><W><K><P><G><Q><P><D><D><W><Q><G><H><G><L><G><G><G><E><D><C><A><H><F><H><P><D><G><R><W><N><D><D><V><C><Q><R><P><Y><H><W><V><C><E><A><G><L><G><Q><T><S><Q><E><S><H> | Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.<BOP> | Q8IUN9 |
O00287 | RFXAP_HUMAN | RFX DNA-binding complex 36 kDa subunit | Homo | <M><E><A><Q><G><V><A><E><G><A><G><P><G><A><A><S><G><V><P><H><P><A><A><L><A><P><A><A><A><P><T><L><A><P><A><S><V><A><A><A><A><S><Q><F><T><L><L><V><M><Q><P><C><A><G><Q><D><E><A><A><A><P><G><G><S><V><G><A><G><K><P><V><R><Y><L><C><E><G><A><G><D><G><E><E><E><A><G><E><D><E><A><D><L><L><D><T><S><D><P><P><G><G><G><E><S><A><A><S><L><E><D><L><E><D><E><E><T><H><S><G><G><E><G><S><S><G><G><A><R><R><R><G><S><G><G><G><S><M><S><K><T><C><T><Y><E><G><C><S><E><T><T><S><Q><V><A><K><Q><R><K><P><W><M><C><K><K><H><R><N><K><M><Y><K><D><K><Y><K><K><K><K><S><D><Q><A><L><N><C><G><G><T><A><S><T><G><S><A><G><N><V><K><L><E><E><S><A><D><N><I><L><S><I><V><K><Q><R><T><G><S><F><G><D><R><P><A><R><P><T><L><L><E><Q><V><L><N><Q><K><R><L><S><L><L><R><S><P><E><V><V><Q><F><L><Q><K><Q><Q><Q><L><L><N><Q><Q><V><L><E><Q><R><Q><Q><Q><F><P><G><T><S><M> | Part of the RFX complex that binds to the X-box of MHC II promoters.<BOP> | O00287 |
Q9BRK5 | CAB45_HUMAN | Stromal cell-derived factor 4 | Homo | <M><V><W><P><W><V><A><M><A><S><R><W><G><P><L><I><G><L><A><P><C><C><L><W><L><L><G><A><V><L><L><M><D><A><S><A><R><P><A><N><H><S><S><T><R><E><R><V><A><N><R><E><E><N><E><I><L><P><P><D><H><L><N><G><V><K><L><E><M><D><G><H><L><N><R><G><F><H><Q><E><V><F><L><G><K><D><L><G><G><F><D><E><D><A><E><P><R><R><S><R><R><K><L><M><V><I><F><S><K><V><D><V><N><T><D><R><K><I><S><A><K><E><M><Q><R><W><I><M><E><K><T><A><E><H><F><Q><E><A><M><E><E><S><K><T><H><F><R><A><V><D><P><D><G><D><G><H><V><S><W><D><E><Y><K><V><K><F><L><A><S><K><G><H><S><E><K><E><V><A><D><A><I><R><L><N><E><E><L><K><V><D><E><E><T><Q><E><V><L><E><N><L><K><D><R><W><Y><Q><A><D><S><P><P><A><D><L><L><L><T><E><E><E><F><L><S><F><L><H><P><E><H><S><R><G><M><L><R><F><M><V><K><E><I><V><R><D><L><D><Q><D><G><D><K><Q><L><S><V><P><E><F><I><S><L><P><V><G><T><V><E><N><Q><Q><G><Q><D><I><D><D><N><W><V><K><D><R><K><K><E><F><E><E><L><I><D><S><N><H><D><G><I><V><T><A><E><E><L><E><S><Y><M><D><P><M><N><E><Y><N><A><L><N><E><A><K><Q><M><I><A><V><A><D><E><N><Q><N><H><H><L><E><P><E><E><V><L><K><Y><S><E><F><F><T><G><S><K><L><V><D><Y><A><R><S><V><H><E><E><F> | Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.<BOP> | Q9BRK5 |
Q9H845 | ACAD9_HUMAN | Acyl-CoA dehydrogenase family member 9 | Homo | <M><S><G><C><G><L><F><L><R><T><T><A><A><A><R><A><C><R><G><L><V><V><S><T><A><N><R><R><L><L><R><T><S><P><P><V><R><A><F><A><K><E><L><F><L><G><K><I><K><K><K><E><V><F><P><F><P><E><V><S><Q><D><E><L><N><E><I><N><Q><F><L><G><P><V><E><K><F><F><T><E><E><V><D><S><R><K><I><D><Q><E><G><K><I><P><D><E><T><L><E><K><L><K><S><L><G><L><F><G><L><Q><V><P><E><E><Y><G><G><L><G><F><S><N><T><M><Y><S><R><L><G><E><I><I><S><M><D><G><S><I><T><V><T><L><A><A><H><Q><A><I><G><L><K><G><I><I><L><A><G><T><E><E><Q><K><A><K><Y><L><P><K><L><A><S><G><E><H><I><A><A><F><C><L><T><E><P><A><S><G><S><D><A><A><S><I><R><S><R><A><T><L><S><E><D><K><K><H><Y><I><L><N><G><S><K><V><W><I><T><N><G><G><L><A><N><I><F><T><V><F><A><K><T><E><V><V><D><S><D><G><S><V><K><D><K><I><T><A><F><I><V><E><R><D><F><G><G><V><T><N><G><K><P><E><D><K><L><G><I><R><G><S><N><T><C><E><V><H><F><E><N><T><K><I><P><V><E><N><I><L><G><E><V><G><D><G><F><K><V><A><M><N><I><L><N><S><G><R><F><S><M><G><S><V><V><A><G><L><L><K><R><L><I><E><M><T><A><E><Y><A><C><T><R><K><Q><F><N><K><R><L><S><E><F><G><L><I><Q><E><K><F><A><L><M><A><Q><K><A><Y><V><M><E><S><M><T><Y><L><T><A><G><M><L><D><Q><P><G><F><P><D><C><S><I><E><A><A><M><V><K><V><F><S><S><E><A><A><W><Q><C><V><S><E><A><L><Q><I><L><G><G><L><G><Y><T><R><D><Y><P><Y><E><R><I><L><R><D><T><R><I><L><L><I><F><E><G><T><N><E><I><L><R><M><Y><I><A><L><T><G><L><Q><H><A><G><R><I><L><T><T><R><I><H><E><L><K><Q><A><K><V><S><T><V><M><D><T><V><G><R><R><L><R><D><S><L><G><R><T><V><D><L><G><L><T><G><N><H><G><V><V><H><P><S><L><A><D><S><A><N><K><F><E><E><N><T><Y><C><F><G><R><T><V><E><T><L><L><L><R><F><G><K><T><I><M><E><E><Q><L><V><L><K><R><V><A><N><I><L><I><N><L><Y><G><M><T><A><V><L><S><R><A><S><R><S><I><R><I><G><L><R><N><H><D><H><E><V><L><L><A><N><T><F><C><V><E><A><Y><L><Q><N><L><F><S><L><S><Q><L><D><K><Y><A><P><E><N><L><D><E><Q><I><K><K><V><S><Q><Q><I><L><E><K><R><A><Y><I><C><A><H><P><L><D><R><T><C> | As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation . This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs . However, in vivo, it does not seem to play a primary role in fatty acid oxidation . In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein .<BOP> | Q9H845 |
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