accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q9GZZ0 | HXD1_HUMAN | Homeobox protein Hox-GG | Homo | <M><S><S><Y><L><E><Y><V><S><C><S><S><S><G><G><V><G><G><D><V><L><S><L><A><P><K><F><C><R><S><D><A><R><P><V><A><L><Q><P><A><F><P><L><G><N><G><D><G><A><F><V><S><C><L><P><L><A><A><A><R><P><S><P><S><P><P><A><A><P><A><R><P><S><V><P><P><P><A><A><P><Q><Y><A><Q><C><T><L><E><G><A><Y><E><P><G><A><A><P><A><A><A><A><G><G><A><D><Y><G><F><L><G><S><G><P><A><Y><D><F><P><G><V><L><G><R><A><A><D><D><G><G><S><H><V><H><Y><A><T><S><A><V><F><S><G><G><G><S><F><L><L><S><G><Q><V><D><Y><A><A><F><G><E><P><G><P><F><P><A><C><L><K><A><S><A><D><G><H><P><G><A><F><Q><T><A><S><P><A><P><G><T><Y><P><K><S><V><S><P><A><S><G><L><P><A><A><F><S><T><F><E><W><M><K><V><K><R><N><A><S><K><K><G><K><L><A><E><Y><G><A><A><S><P><S><S><A><I><R><T><N><F><S><T><K><Q><L><T><E><L><E><K><E><F><H><F><N><K><Y><L><T><R><A><R><R><I><E><I><A><N><C><L><H><L><N><D><T><Q><V><K><I><W><F><Q><N><R><R><M><K><Q><K><K><R><E><R><E><G><L><L><A><T><A><I><P><V><A><P><L><Q><L><P><L><S><G><T><T><P><T><K><F><I><K><N><P><G><S><P><S><Q><S><Q><E><P><S> | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.<BOP> | Q9GZZ0 |
P53701 | CCHL_HUMAN | Cytochrome c-type heme lyase | Homo | <M><G><L><S><P><S><A><P><A><V><A><V><Q><A><S><N><A><S><A><S><P><P><S><G><C><P><M><H><E><G><K><M><K><G><C><P><V><N><T><E><P><S><G><P><T><C><E><K><K><T><Y><S><V><P><A><H><Q><E><R><A><Y><E><Y><V><E><C><P><I><R><G><T><A><A><E><N><K><E><N><L><D><P><S><N><L><M><P><P><P><N><Q><T><P><A><P><D><Q><P><F><A><L><S><T><V><R><E><E><S><S><I><P><R><A><D><S><E><K><K><W><V><Y><P><S><E><Q><M><F><W><N><A><M><L><K><K><G><W><K><W><K><D><E><D><I><S><Q><K><D><M><Y><N><I><I><R><I><H><N><Q><N><N><E><Q><A><W><K><E><I><L><K><W><E><A><L><H><A><A><E><C><P><C><G><P><S><L><I><R><F><G><G><K><A><K><E><Y><S><P><R><A><R><I><R><S><W><M><G><Y><E><L><P><F><D><R><H><D><W><I><I><N><R><C><G><T><E><V><R><Y><V><I><D><Y><Y><D><G><G><E><V><N><K><D><Y><Q><F><T><I><L><D><V><R><P><A><L><D><S><L><S><A><V><W><D><R><M><K><V><A><W><W><R><W><T><S> | Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.<BOP> | P53701 |
Q96SQ9 | CP2S1_HUMAN | Thromboxane-A synthase | Homo | <M><E><A><T><G><T><W><A><L><L><L><A><L><A><L><L><L><L><L><T><L><A><L><S><G><T><R><A><R><G><H><L><P><P><G><P><T><P><L><P><L><L><G><N><L><L><Q><L><R><P><G><A><L><Y><S><G><L><M><R><L><S><K><K><Y><G><P><V><F><T><I><Y><L><G><P><W><R><P><V><V><V><L><V><G><Q><E><A><V><R><E><A><L><G><G><Q><A><E><E><F><S><G><R><G><T><V><A><M><L><E><G><T><F><D><G><H><G><V><F><F><S><N><G><E><R><W><R><Q><L><R><K><F><T><M><L><A><L><R><D><L><G><M><G><K><R><E><G><E><E><L><I><Q><A><E><A><R><C><L><V><E><T><F><Q><G><T><E><G><R><P><F><D><P><S><L><L><L><A><Q><A><T><S><N><V><V><C><S><L><L><F><G><L><R><F><S><Y><E><D><K><E><F><Q><A><V><V><R><A><A><G><G><T><L><L><G><V><S><S><Q><G><G><Q><T><Y><E><M><F><S><W><F><L><R><P><L><P><G><P><H><K><Q><L><L><H><H><V><S><T><L><A><A><F><T><V><R><Q><V><Q><Q><H><Q><G><N><L><D><A><S><G><P><A><R><D><L><V><D><A><F><L><L><K><M><A><Q><E><E><Q><N><P><G><T><E><F><T><N><K><N><M><L><M><T><V><I><Y><L><L><F><A><G><T><M><T><V><S><T><T><V><G><Y><T><L><L><L><L><M><K><Y><P><H><V><Q><K><W><V><R><E><E><L><N><R><E><L><G><A><G><Q><A><P><S><L><G><D><R><T><R><L><P><Y><T><D><A><V><L><H><E><A><Q><R><L><L><A><L><V><P><M><G><I><P><R><T><L><M><R><T><T><R><F><R><G><Y><T><L><P><Q><G><T><E><V><F><P><L><L><G><S><I><L><H><D><P><N><I><F><K><H><P><E><E><F><N><P><D><R><F><L><D><A><D><G><R><F><R><K><H><E><A><F><L><P><F><S><L><G><K><R><V><C><L><G><E><G><L><A><K><A><E><L><F><L><F><F><T><T><I><L><Q><A><F><S><L><E><S><P><C><P><P><D><T><L><S><L><K><P><T><V><S><G><L><F><N><I><P><P><A><F><Q><L><Q><V><R><P><T><D><L><H><S><T><T><Q><T><R> | A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids . In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) . Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage .<BOP> | Q96SQ9 |
Q9BS31 | ZN649_HUMAN | Zinc finger protein 649 | Homo | <M><T><K><A><Q><E><S><L><T><L><E><D><V><A><V><D><F><T><W><E><E><W><Q><F><L><S><P><A><Q><K><D><L><Y><R><D><V><M><L><E><N><Y><S><N><L><V><S><V><G><Y><Q><A><G><K><P><D><A><L><T><K><L><E><Q><G><E><P><L><W><T><L><E><D><E><I><H><S><P><A><H><P><E><I><E><K><A><D><D><H><L><Q><Q><P><L><Q><N><Q><K><I><L><K><R><T><G><Q><R><Y><E><H><G><R><T><L><K><S><Y><L><G><L><T><N><Q><S><R><R><Y><N><R><K><E><P><A><E><F><N><G><D><G><A><F><L><H><D><N><H><E><Q><M><P><T><E><I><E><F><P><E><S><R><K><P><I><S><T><K><S><Q><F><L><K><H><Q><Q><T><H><N><I><E><K><A><H><E><C><T><D><C><G><K><A><F><L><K><K><S><Q><L><T><E><H><K><R><I><H><T><G><K><K><P><H><V><C><S><L><C><G><K><A><F><Y><K><K><Y><R><L><T><E><H><E><R><A><H><R><G><E><K><P><H><G><C><S><L><C><G><K><A><F><Y><K><R><Y><R><L><T><E><H><E><R><A><H><K><G><E><K><P><Y><G><C><S><E><C><G><K><A><F><P><R><K><S><E><L><T><E><H><Q><R><I><H><T><G><I><K><P><H><Q><C><S><E><C><G><R><A><F><S><R><K><S><L><L><V><V><H><Q><R><T><H><T><G><E><K><P><H><T><C><S><E><C><G><K><G><F><I><Q><K><G><N><L><N><I><H><Q><R><T><H><T><G><E><K><P><Y><G><C><I><D><C><G><K><A><F><S><Q><K><S><C><L><V><A><H><Q><R><Y><H><T><G><K><T><P><F><V><C><P><E><C><G><Q><P><C><S><Q><K><S><G><L><I><R><H><Q><K><I><H><S><G><E><K><P><Y><K><C><S><D><C><G><K><A><F><L><T><K><T><M><L><I><V><H><H><R><T><H><T><G><E><R><P><Y><G><C><D><E><C><E><K><A><Y><F><Y><M><S><C><L><V><K><H><K><R><I><H><S><R><E><K><R><G><D><S><V><K><V><E><N><P><S><T><A><S><H><S><L><S><P><S><E><H><V><Q><G><K><S><P><V><N><M><V><T><V><A><M><V><A><G><Q><C><E><F><A><H><I><L><H><S> | Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.<BOP> | Q9BS31 |
Q9GZS9 | CHST5_HUMAN | N-acetylglucosamine 6-O-sulfotransferase 3 | Homo | <M><G><M><R><A><R><V><P><K><V><A><H><S><T><R><R><P><P><A><A><R><M><W><L><P><R><F><S><S><K><T><V><T><V><L><L><L><A><Q><T><T><C><L><L><L><F><I><I><S><R><P><G><P><S><S><P><A><G><G><E><D><R><V><H><V><L><V><L><S><S><W><R><S><G><S><S><F><L><G><Q><L><F><S><Q><H><P><D><V><F><Y><L><M><E><P><A><W><H><V><W><T><T><L><S><Q><G><S><A><A><T><L><H><M><A><V><R><D><L><M><R><S><I><F><L><C><D><M><D><V><F><D><A><Y><M><P><Q><S><R><N><L><S><A><F><F><N><W><A><T><S><R><A><L><C><S><P><P><A><C><S><A><F><P><R><G><T><I><S><K><Q><D><V><C><K><T><L><C><T><R><Q><P><F><S><L><A><R><E><A><C><R><S><Y><S><H><V><V><L><K><E><V><R><F><F><N><L><Q><V><L><Y><P><L><L><S><D><P><A><L><N><L><R><I><V><H><L><V><R><D><P><R><A><V><L><R><S><R><E><A><A><G><P><I><L><A><R><D><N><G><I><V><L><G><T><N><G><K><W><V><E><A><D><P><H><L><R><L><I><R><E><V><C><R><S><H><V><R><I><A><E><A><A><T><L><K><P><P><P><F><L><R><G><R><Y><R><L><V><R><F><E><D><L><A><R><E><P><L><A><E><I><R><A><L><Y><A><F><T><G><L><T><L><T><P><Q><L><E><A><W><I><H><N><I><T><H><G><S><G><I><G><K><P><I><E><A><F><H><T><S><S><R><N><A><R><N><V><S><Q><A><W><R><H><A><L><P><F><T><K><I><L><R><V><Q><E><V><C><A><G><A><L><Q><L><L><G><Y><R><P><V><Y><S><A><D><Q><Q><R><D><L><T><L><D><L><V><L><P><R><G><P><D><H><F><S><W><A><S><P><D> | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location.<BOP> | Q9GZS9 |
Q8NGQ1 | OR9G4_HUMAN | Olfactory receptor OR11-216 | Homo | <M><I><F><P><S><H><D><S><Q><A><F><T><S><V><D><M><E><V><G><N><C><T><I><L><T><E><F><I><L><L><G><F><S><A><D><S><Q><W><Q><P><I><L><F><G><V><F><L><M><L><Y><L><I><T><L><S><G><N><M><T><L><V><I><L><I><R><T><D><S><H><L><H><T><P><M><Y><F><F><I><G><N><L><S><F><L><D><F><W><Y><T><S><V><Y><T><P><K><I><L><A><S><C><V><S><E><D><K><R><I><S><L><A><G><C><G><A><Q><L><F><F><S><C><V><V><A><Y><T><E><C><Y><L><L><A><A><M><A><Y><D><R><H><A><A><I><C><N><P><L><L><Y><S><G><T><M><S><T><A><L><C><T><G><L><V><A><G><S><Y><I><G><G><F><L><N><A><I><A><H><T><A><N><T><F><R><L><H><F><C><G><K><N><I><I><D><H><F><F><C><D><A><P><P><L><V><K><M><S><C><T><N><T><R><V><Y><E><K><V><L><L><G><V><V><G><F><T><V><L><S><S><I><L><A><I><L><I><S><Y><V><N><I><L><L><A><I><L><R><I><H><S><A><S><G><R><H><K><A><F><S><T><C><A><S><H><L><I><S><V><M><L><F><Y><G><S><L><L><F><M><Y><S><R><P><S><S><T><Y><S><L><E><R><D><K><V><A><A><L><F><Y><T><V><I><N><P><L><L><N><P><L><I><Y><S><L><R><N><K><D><I><K><E><A><F><R><K><A><T><Q><T><I><Q><P><Q><T> | Odorant receptor.<BOP> | Q8NGQ1 |
O95633 | FSTL3_HUMAN | Follistatin-related gene protein | Homo | <M><R><P><G><A><P><G><P><L><W><P><L><P><W><G><A><L><A><W><A><V><G><F><V><S><S><M><G><S><G><N><P><A><P><G><G><V><C><W><L><Q><Q><G><Q><E><A><T><C><S><L><V><L><Q><T><D><V><T><R><A><E><C><C><A><S><G><N><I><D><T><A><W><S><N><L><T><H><P><G><N><K><I><N><L><L><G><F><L><G><L><V><H><C><L><P><C><K><D><S><C><D><G><V><E><C><G><P><G><K><A><C><R><M><L><G><G><R><P><R><C><E><C><A><P><D><C><S><G><L><P><A><R><L><Q><V><C><G><S><D><G><A><T><Y><R><D><E><C><E><L><R><A><A><R><C><R><G><H><P><D><L><S><V><M><Y><R><G><R><C><R><K><S><C><E><H><V><V><C><P><R><P><Q><S><C><V><V><D><Q><T><G><S><A><H><C><V><V><C><R><A><A><P><C><P><V><P><S><S><P><G><Q><E><L><C><G><N><N><N><V><T><Y><I><S><S><C><H><M><R><Q><A><T><C><F><L><G><R><S><I><G><V><R><H><A><G><S><C><A><G><T><P><E><E><P><P><G><G><E><S><A><E><E><E><E><N><F><V> | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.<BOP> | O95633 |
Q8N5J2 | MINY1_HUMAN | Protein FAM63A | Homo | <M><E><Y><H><Q><P><E><D><P><A><P><G><K><A><G><T><A><E><A><V><I><P><E><N><H><E><V><L><A><G><P><D><E><H><P><Q><D><T><D><A><R><D><A><D><G><E><A><R><E><R><E><P><A><D><Q><A><L><L><P><S><Q><C><G><D><N><L><E><S><P><L><P><E><A><S><S><A><P><P><G><P><T><L><G><T><L><P><E><V><E><T><I><R><A><C><S><M><P><Q><E><L><P><Q><S><P><R><T><R><Q><P><E><P><D><F><Y><C><V><K><W><I><P><W><K><G><E><Q><T><P><I><I><T><Q><S><T><N><G><P><C><P><L><L><A><I><M><N><I><L><F><L><Q><W><K><V><K><L><P><P><Q><K><E><V><I><T><S><D><E><L><M><A><H><L><G><N><C><L><L><S><I><K><P><Q><E><K><S><E><G><L><Q><L><N><F><Q><Q><N><V><D><D><A><M><T><V><L><P><K><L><A><T><G><L><D><V><N><V><R><F><T><G><V><S><D><F><E><Y><T><P><E><C><S><V><F><D><L><L><G><I><P><L><Y><H><G><W><L><V><D><P><Q><S><P><E><A><V><R><A><V><G><K><L><S><Y><N><Q><L><V><E><R><I><I><T><C><K><H><S><S><D><T><N><L><V><T><E><G><L><I><A><E><Q><F><L><E><T><T><A><A><Q><L><T><Y><H><G><L><C><E><L><T><A><A><A><K><E><G><E><L><S><V><F><F><R><N><N><H><F><S><T><M><T><K><H><K><S><H><L><Y><L><L><V><T><D><Q><G><F><L><Q><E><E><Q><V><V><W><E><S><L><H><N><V><D><G><D><S><C><F><C><D><S><D><F><H><L><S><H><S><L><G><K><G><P><G><A><E><G><G><S><G><S><P><E><T><Q><L><Q><V><D><Q><D><Y><L><I><A><L><S><L><Q><Q><Q><Q><P><R><G><P><L><G><L><T><D><L><E><L><A><Q><Q><L><Q><Q><E><E><Y><Q><Q><Q><Q><A><A><Q><P><V><R><M><R><T><R><V><L><S><L><Q><G><R><G><A><T><S><G><R><P><A><G><E><R><R><Q><R><P><K><H><E><S><D><C><I><L><L> | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.<BOP> | Q8N5J2 |
P01737 | TVA84_HUMAN | T cell receptor alpha chain V region PY14 | Homo | <M><L><L><L><L><V><P><V><L><E><V><I><F><T><L><G><G><T><R><A><Q><S><V><T><Q><L><G><S><H><V><S><V><S><E><G><A><L><V><L><L><R><C><N><Y><S><S><S><V><P><P><Y><L><F><W><Y><V><Q><Y><P><N><Q><G><L><Q><L><L><L><K><Y><T><S><A><A><T><L><V><K><G><I><N><G><F><E><A><E><F><K><K><S><E><T><S><F><H><L><T><K><P><S><A><H><M><S><D><A><A><E><Y><F><C><A><V><S> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. | P01737 |
P54257 | HAP1_HUMAN | Neuroan 1 | Homo | <M><R><P><K><R><L><G><R><C><C><A><G><S><R><L><G><P><G><D><P><A><A><L><T><C><A><P><S><P><S><A><S><P><A><P><E><P><S><A><Q><P><Q><A><R><G><T><G><Q><R><V><G><S><R><A><T><S><G><S><Q><F><L><S><E><A><R><T><G><A><R><P><A><S><E><A><G><A><K><A><G><A><R><R><P><S><A><F><S><A><I><Q><G><D><V><R><S><M><P><D><N><S><D><A><P><W><T><R><F><V><F><Q><G><P><F><G><S><R><A><T><G><R><G><T><G><K><A><A><G><I><W><K><T><P><A><A><Y><V><G><R><R><P><G><V><S><G><P><E><R><A><A><F><I><R><E><L><E><E><A><L><C><P><N><L><P><P><P><V><K><K><I><T><Q><E><D><V><K><V><M><L><Y><L><L><E><E><L><L><P><P><V><W><E><S><V><T><Y><G><M><V><L><Q><R><E><R><D><L><N><T><A><A><R><I><G><Q><S><L><V><K><Q><N><S><V><L><M><E><E><N><S><K><L><E><A><L><L><G><S><A><K><E><E><I><L><Y><L><R><H><Q><V><N><L><R><D><E><L><L><Q><L><Y><S><D><S><D><E><E><D><E><D><E><E><E><E><E><E><E><K><E><A><E><E><E><Q><E><E><E><E><A><E><E><D><L><Q><C><A><H><P><C><D><A><P><K><L><I><S><Q><E><A><L><L><H><Q><H><H><C><P><Q><L><E><A><L><Q><E><K><L><R><L><L><E><E><E><N><H><Q><L><R><E><E><A><S><Q><L><D><T><L><E><D><E><E><Q><M><L><I><L><E><C><V><E><Q><F><S><E><A><S><Q><Q><M><A><E><L><S><E><V><L><V><L><R><L><E><N><Y><E><R><Q><Q><Q><E><V><A><R><L><Q><A><Q><V><L><K><L><Q><Q><R><C><R><M><Y><G><A><E><T><E><K><L><Q><K><Q><L><A><S><E><K><E><I><Q><M><Q><L><Q><E><E><S><V><W><V><G><S><Q><L><Q><D><L><R><E><K><Y><M><D><C><G><G><M><L><I><E><M><Q><E><E><V><K><T><L><R><Q><Q><P><P><V><S><T><G><S><A><T><H><Y><P><Y><S><V><P><L><E><T><L><P><G><F><Q><E><T><L><A><E><E><L><R><T><S><L><R><R><M><I><S><D><P><V><Y><F><M><E><R><N><Y><E><M><P><R><G><D><T><S><S><L><R><Y><D><F><R><Y><S><E><D><R><E><Q><V><R><G><F><E><A><E><E><G><L><M><L><A><A><D><I><M><R><G><E><D><F><T><P><A><E><E><F><V><P><Q><E><E><L><G><A><A><K><K><V><P><A><E><E><G><V><M><E><E><A><E><L><V><S><E><E><T><E><G><W><E><E><V><E><L><E><L><D><E><A><T><R><M><N><V><V><T><S><A><L><E><A><S><G><L><G><P><S><H><L><D><M><N><Y><V><L><Q><Q><L><A><N><W><Q><D><A><H><Y><R><R><Q><L><R><W><K><M><L><Q><K><G><E><C><P><H><G><A><L><P><A><A><S><R><T><S><C><R><S><S><C><R> | Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient | P54257 |
Q9NX52 | RHBL2_HUMAN | Rhomboid-related protein 2, C-terminal fragment | Homo | <M><A><A><V><H><D><L><E><M><E><S><M><N><L><N><M><G><R><E><M><K><E><E><L><E><E><E><E><K><M><R><E><D><G><G><G><K><D><R><A><K><S><K><K><V><H><R><I><V><S><K><W><M><L><P><E><K><S><R><G><T><Y><L><E><R><A><N><C><F><P><P><P><V><F><I><I><S><I><S><L><A><E><L><A><V><F><I><Y><Y><A><V><W><K><P><Q><K><Q><W><I><T><L><D><T><G><I><L><E><S><P><F><I><Y><S><P><E><K><R><E><E><A><W><R><F><I><S><Y><M><L><V><H><A><G><V><Q><H><I><L><G><N><L><C><M><Q><L><V><L><G><I><P><L><E><M><V><H><K><G><L><R><V><G><L><V><Y><L><A><G><V><I><A><G><S><L><A><S><S><I><F><D><P><L><R><Y><L><V><G><A><S><G><G><V><Y><A><L><M><G><G><Y><F><M><N><V><L><V><N><F><Q><E><M><I><P><A><F><G><I><F><R><L><L><I><I><I><L><I><I><V><L><D><M><G><F><A><L><Y><R><R><F><F><V><P><E><D><G><S><P><V><S><F><A><A><H><I><A><G><G><F><A><G><M><S><I><G><Y><T><V><F><S><C><F><D><K><A><L><L><K><D><P><R><F><W><I><A><I><A><A><Y><L><A><C><V><L><F><A><V><F><F><N><I><F><L><S><P><A><N> | Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.<BOP> | Q9NX52 |
Q8N4Q0 | PTGR3_HUMAN | null | Homo | <M><L><R><L><V><P><T><G><A><R><A><I><V><D><M><S><Y><A><R><H><F><L><D><F><Q><G><S><A><I><P><Q><A><M><Q><K><L><V><V><T><R><L><S><P><N><F><R><E><A><V><T><L><S><R><D><C><P><V><P><L><P><G><D><G><D><L><L><V><R><N><R><F><V><G><V><N><A><S><D><I><N><Y><S><A><G><R><Y><D><P><S><V><K><P><P><F><D><I><G><F><E><G><I><G><E><V><V><A><L><G><L><S><A><S><A><R><Y><T><V><G><Q><A><V><A><Y><M><A><P><G><S><F><A><E><Y><T><V><V><P><A><S><I><A><T><P><V><P><S><V><K><P><E><Y><L><T><L><L><V><S><G><T><T><A><Y><I><S><L><K><E><L><G><G><L><S><E><G><K><K><V><L><V><T><A><A><A><G><G><T><G><Q><F><A><M><Q><L><S><K><K><A><K><C><H><V><I><G><T><C><S><S><D><E><K><S><A><F><L><K><S><L><G><C><D><R><P><I><N><Y><K><T><E><P><V><G><T><V><L><K><Q><E><Y><P><E><G><V><D><V><V><Y><E><S><V><G><G><A><M><F><D><L><A><V><D><A><L><A><T><K><G><R><L><I><V><I><G><F><I><S><G><Y><Q><T><P><T><G><L><S><P><V><K><A><G><T><L><P><A><K><L><L><K><K><S><A><S><V><Q><G><F><F><L><N><H><Y><L><S><K><Y><Q><A><A><M><S><H><L><L><E><M><C><V><S><G><D><L><V><C><E><V><D><L><G><D><L><S><P><E><G><R><F><T><G><L><E><S><I><F><R><A><V><N><Y><M><Y><M><G><K><N><T><G><K><I><V><V><E><L><P><H><S><V><N><S><K><L> | Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.<BOP> | Q8N4Q0 |
Q8WWA0 | ITLN1_HUMAN | Omentin | Homo | <M><N><Q><L><S><F><L><L><F><L><I><A><T><T><R><G><W><S><T><D><E><A><N><T><Y><F><K><E><W><T><C><S><S><S><P><S><L><P><R><S><C><K><E><I><K><D><E><C><P><S><A><F><D><G><L><Y><F><L><R><T><E><N><G><V><I><Y><Q><T><F><C><D><M><T><S><G><G><G><G><W><T><L><V><A><S><V><H><E><N><D><M><R><G><K><C><T><V><G><D><R><W><S><S><Q><Q><G><S><K><A><V><Y><P><E><G><D><G><N><W><A><N><Y><N><T><F><G><S><A><E><A><A><T><S><D><D><Y><K><N><P><G><Y><Y><D><I><Q><A><K><D><L><G><I><W><H><V><P><N><K><S><P><M><Q><H><W><R><N><S><S><L><L><R><Y><R><T><D><T><G><F><L><Q><T><L><G><H><N><L><F><G><I><Y><Q><K><Y><P><V><K><Y><G><E><G><K><C><W><T><D><N><G><P><V><I><P><V><V><Y><D><F><G><D><A><Q><K><T><A><S><Y><Y><S><P><Y><G><Q><R><E><F><T><A><G><F><V><Q><F><R><V><F><N><N><E><R><A><A><N><A><L><C><A><G><M><R><V><T><G><C><N><T><E><H><H><C><I><G><G><G><G><Y><F><P><E><A><S><P><Q><Q><C><G><D><F><S><G><F><D><W><S><G><Y><G><T><H><V><G><Y><S><S><S><R><E><I><T><E><A><A><V><L><L><F><Y><R> | Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner . Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) . Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris . Does not bind human glycans . Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes . Increases AKT phosphorylation in the absence and presence of insulin . May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption .<BOP> | Q8WWA0 |
Q8TAF7 | ZN461_HUMAN | Gonadotropin-inducible ovary transcription repressor 1 | Homo | <M><A><H><E><L><V><M><F><R><D><V><A><I><D><V><S><Q><E><E><W><E><C><L><N><P><A><Q><R><N><L><Y><K><E><V><M><L><E><N><Y><S><N><L><V><S><L><G><L><S><V><S><K><P><A><V><I><S><S><L><E><Q><G><K><E><P><W><M><V><V><R><E><E><T><G><R><W><C><P><G><T><W><K><T><W><G><F><H><N><N><F><L><D><N><N><E><A><T><D><I><N><A><D><L><A><S><R><D><E><P><Q><K><L><S><P><K><R><D><I><Y><E><T><E><L><S><Q><W><V><N><M><E><E><F><K><S><H><S><P><E><R><S><I><F><S><A><I><W><E><G><N><C><H><F><E><Q><H><Q><G><Q><E><E><G><Y><F><R><Q><L><M><I><N><H><E><N><M><P><I><F><S><Q><H><T><L><L><T><Q><E><F><Y><D><R><E><K><I><S><E><C><K><K><C><R><K><I><F><S><Y><H><L><F><F><S><H><H><K><R><T><H><S><K><E><L><S><E><C><K><E><C><T><E><I><V><N><T><P><C><L><F><K><Q><Q><T><I><Q><N><G><D><K><C><N><E><C><K><E><C><W><K><A><F><V><H><C><S><Q><L><K><H><L><R><I><H><N><G><E><K><R><Y><E><C><N><E><C><G><K><A><F><N><Y><G><S><E><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><Q><R><S><Q><L><T><Q><H><Q><R><L><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><I><R><G><F><Q><L><T><E><H><L><R><L><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><T><F><R><H><R><S><H><L><T><I><H><Q><R><I><H><T><G><E><K><P><Y><E><C><R><E><C><G><K><A><F><S><Y><H><S><S><F><S><H><H><Q><K><I><H><S><G><K><K><P><Y><E><C><H><E><C><G><K><A><F><C><D><G><L><Q><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><T><F><R><Q><C><S><H><L><K><R><H><Q><R><I><H><T><G><E><K><P><H><E><C><M><I><C><G><K><A><F><R><L><H><S><H><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><Y><H><S><S><F><S><H><H><Q><R><I><H><S><G><K><K><P><Y><Q><C><G><K><A><F><N><H><R><L><Q><L><N><L><H><Q><T><L><H><T><G><E><K><P><V><R><F><P><L><L><P><P><H><P><S><L><A><S> | May be involved in transcriptional regulation.<BOP> | Q8TAF7 |
Q15349 | KS6A2_HUMAN | pp90RSK3 | Homo | <M><D><L><S><M><K><K><F><A><V><R><R><F><F><S><V><Y><L><R><R><K><S><R><S><K><S><S><S><L><S><R><L><E><E><E><G><V><V><K><E><I><D><I><S><H><H><V><K><E><G><F><E><K><A><D><P><S><Q><F><E><L><L><K><V><L><G><Q><G><S><Y><G><K><V><F><L><V><R><K><V><K><G><S><D><A><G><Q><L><Y><A><M><K><V><L><K><K><A><T><L><K><V><R><D><R><V><R><S><K><M><E><R><D><I><L><A><E><V><N><H><P><F><I><V><K><L><H><Y><A><F><Q><T><E><G><K><L><Y><L><I><L><D><F><L><R><G><G><D><L><F><T><R><L><S><K><E><V><M><F><T><E><E><D><V><K><F><Y><L><A><E><L><A><L><A><L><D><H><L><H><S><L><G><I><I><Y><R><D><L><K><P><E><N><I><L><L><D><E><E><G><H><I><K><I><T><D><F><G><L><S><K><E><A><I><D><H><D><K><R><A><Y><S><F><C><G><T><I><E><Y><M><A><P><E><V><V><N><R><R><G><H><T><Q><S><A><D><W><W><S><F><G><V><L><M><F><E><M><L><T><G><S><L><P><F><Q><G><K><D><R><K><E><T><M><A><L><I><L><K><A><K><L><G><M><P><Q><F><L><S><G><E><A><Q><S><L><L><R><A><L><F><K><R><N><P><C><N><R><L><G><A><G><I><D><G><V><E><E><I><K><R><H><P><F><F><V><T><I><D><W><N><T><L><Y><R><K><E><I><K><P><P><F><K><P><A><V><G><R><P><E><D><T><F><H><F><D><P><E><F><T><A><R><T><P><T><D><S><P><G><V><P><P><S><A><N><A><H><H><L><F><R><G><F><S><F><V><A><S><S><L><I><Q><E><P><S><Q><Q><D><L><H><K><V><P><V><H><P><I><V><Q><Q><L><H><G><N><N><I><H><F><T><D><G><Y><E><I><K><E><D><I><G><V><G><S><Y><S><V><C><K><R><C><V><H><K><A><T><D><T><E><Y><A><V><K><I><I><D><K><S><K><R><D><P><S><E><E><I><E><I><L><L><R><Y><G><Q><H><P><N><I><I><T><L><K><D><V><Y><D><D><G><K><F><V><Y><L><V><M><E><L><M><R><G><G><E><L><L><D><R><I><L><R><Q><R><Y><F><S><E><R><E><A><S><D><V><L><C><T><I><T><K><T><M><D><Y><L><H><S><Q><G><V><V><H><R><D><L><K><P><S><N><I><L><Y><R><D><E><S><G><S><P><E><S><I><R><V><C><D><F><G><F><A><K><Q><L><R><A><G><N><G><L><L><M><T><P><C><Y><T><A><N><F><V><A><P><E><V><L><K><R><Q><G><Y><D><A><A><C><D><I><W><S><L><G><I><L><L><Y><T><M><L><A><G><F><T><P><F><A><N><G><P><D><D><T><P><E><E><I><L><A><R><I><G><S><G><K><Y><A><L><S><G><G><N><W><D><S><I><S><D><A><A><K><D><V><V><S><K><M><L><H><V><D><P><H><Q><R><L><T><A><M><Q><V><L><K><H><P><W><V><V><N><R><E><Y><L><S><P><N><Q><L><S><R><Q><D><V><H><L><V><K><G><A><M><A><A><T><Y><F><A><L><N><R><T><P><Q><A><P><R><L><E><P><V><L><S><S><N><L><A><Q><R><R><G><M><K><R><L><T><S><T><R><L> | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.<BOP> | Q15349 |
Q2NL67 | PARP6_HUMAN | Poly [ADP-ribose] polymerase 6 | Homo | <M><D><I><K><G><Q><F><W><N><D><D><D><S><E><G><D><N><E><S><E><E><F><L><Y><G><V><Q><G><S><C><A><A><D><L><Y><R><H><P><Q><L><D><A><D><I><E><A><V><K><E><I><Y><S><E><N><S><V><S><I><R><E><Y><G><T><I><D><D><V><D><I><D><L><H><I><N><I><S><F><L><D><E><E><V><S><T><A><W><K><V><L><R><T><E><P><I><V><L><R><L><R><F><S><L><S><Q><Y><L><D><G><P><E><P><S><I><E><V><F><Q><P><S><N><K><E><G><F><G><L><G><L><Q><L><K><K><I><L><G><M><F><T><S><Q><Q><W><K><H><L><S><N><D><F><L><K><T><Q><Q><E><K><R><H><S><W><F><K><A><S><G><T><I><K><K><F><R><A><G><L><S><I><F><S><P><I><P><K><S><P><S><F><P><I><I><Q><D><S><M><L><K><G><K><L><G><V><P><E><L><R><V><G><R><L><M><N><R><S><I><S><C><T><M><K><N><P><K><V><E><V><F><G><Y><P><P><S><P><Q><A><G><L><L><C><P><Q><H><V><G><L><P><P><P><A><R><T><S><P><L><V><S><G><H><C><K><N><I><P><T><L><E><Y><G><F><L><V><Q><I><M><K><Y><A><E><Q><R><I><P><T><L><N><E><Y><C><V><V><C><D><E><Q><H><V><F><Q><N><G><S><M><L><K><P><A><V><C><T><R><E><L><C><V><F><S><F><Y><T><L><G><V><M><S><G><A><A><E><E><V><A><T><G><A><E><V><V><D><L><L><V><A><M><C><R><A><A><L><E><S><P><R><K><S><I><I><F><E><P><Y><P><S><V><V><D><P><T><D><P><K><T><L><A><F><N><P><K><K><K><N><Y><E><R><L><Q><K><A><L><D><S><V><M><S><I><R><E><M><T><Q><G><S><Y><L><E><I><K><K><Q><M><D><K><L><D><P><L><A><H><P><L><L><Q><W><I><I><S><S><N><R><S><H><I><V><K><L><P><L><S><R><L><K><F><M><H><T><S><H><Q><F><L><L><L><S><S><P><P><A><K><E><A><R><F><R><T><A><K><K><L><Y><G><S><T><F><A><F><H><G><S><H><I><E><N><W><H><S><I><L><R><N><G><L><V><N><A><S><Y><T><K><L><Q><L><H><G><A><A><Y><G><K><G><I><Y><L><S><P><I><S><S><I><S><F><G><Y><S><G><M><G><K><G><Q><H><R><M><P><S><K><D><E><L><V><Q><R><Y><N><R><M><N><T><I><P><Q><T><R><S><I><Q><S><R><F><L><Q><S><R><N><L><N><C><I><A><L><C><E><V><I><T><S><K><D><L><Q><K><H><G><N><I><W><V><C><P><V><S><D><H><V><C><T><R><F><F><F><V><Y><E><D><G><Q><V><G><D><A><N><I><N><T><Q><D><P><K><I><Q><K><E><I><M><R><V><I><G><T><Q><V><Y><T><N> | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.<BOP> | Q2NL67 |
Q99726 | ZNT3_HUMAN | Solute carrier family 30 member 3 | Homo | <M><E><P><S><P><A><A><G><G><L><E><T><T><R><L><V><S><P><R><D><R><G><G><A><G><G><S><L><R><L><K><S><L><F><T><E><P><S><E><P><L><P><E><E><S><K><P><V><E><M><P><F><H><H><C><H><R><D><P><L><P><P><P><G><L><T><P><E><R><L><H><A><R><R><Q><L><Y><A><A><C><A><V><C><F><V><F><M><A><G><E><V><V><G><G><Y><L><A><H><S><L><A><I><M><T><D><A><A><H><L><L><A><D><V><G><S><M><M><G><S><L><F><S><L><W><L><S><T><R><P><A><T><R><T><M><T><F><G><W><H><R><S><E><T><L><G><A><L><A><S><V><V><S><L><W><M><V><T><G><I><L><L><Y><L><A><F><V><R><L><L><H><S><D><Y><H><I><E><G><G><A><M><L><L><T><A><S><I><A><V><C><A><N><L><L><M><A><F><V><L><H><Q><A><G><P><P><H><S><H><G><S><R><G><A><E><Y><A><P><L><E><E><G><P><E><E><P><L><P><L><G><N><T><S><V><R><A><A><F><V><H><V><L><G><D><L><L><Q><S><F><G><V><L><A><A><S><I><L><I><Y><F><K><P><Q><Y><K><A><A><D><P><I><S><T><F><L><F><S><I><C><A><L><G><S><T><A><P><T><L><R><D><V><L><R><I><L><M><E><G><T><P><R><N><V><G><F><E><P><V><R><D><T><L><L><S><V><P><G><V><R><A><T><H><E><L><H><L><W><A><L><T><L><T><Y><H><V><A><S><A><H><L><A><I><D><S><T><A><D><P><E><A><V><L><A><E><A><S><S><R><L><Y><S><R><F><G><F><S><S><C><T><L><Q><V><E><Q><Y><Q><P><E><M><A><Q><C><L><R><C><Q><E><P><P><Q><A> | Zinc ion transporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain.<BOP> | Q99726 |
Q9UKJ0 | PILRB_HUMAN | Cell surface receptor FDFACT | Homo | <M><G><R><P><L><L><L><P><L><L><L><L><L><Q><P><P><A><F><L><Q><P><G><G><S><T><G><S><G><P><S><Y><L><Y><G><V><T><Q><P><K><H><L><S><A><S><M><G><G><S><V><E><I><P><F><S><F><Y><Y><P><W><E><L><A><I><V><P><N><V><R><I><S><W><R><R><G><H><F><H><G><Q><S><F><Y><S><T><R><P><P><S><I><H><K><D><Y><V><N><R><L><F><L><N><W><T><E><G><Q><E><S><G><F><L><R><I><S><N><L><R><K><E><D><Q><S><V><Y><F><C><R><V><E><L><D><T><R><R><S><G><R><Q><Q><L><Q><S><I><K><G><T><K><L><T><I><T><Q><A><V><T><T><T><T><T><W><R><P><S><S><T><T><T><I><A><G><L><R><V><T><E><S><K><G><H><S><E><S><W><H><L><S><L><D><T><A><I><R><V><A><L><A><V><A><V><L><K><T><V><I><L><G><L><L><C><L><L><L><L><W><W><R><R><R><K><G><S><R><A><P><S><S><D><F> | Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.<BOP> | Q9UKJ0 |
O60749 | SNX2_HUMAN | Transformation-related gene 9 protein | Homo | <M><A><A><E><R><E><P><P><P><L><G><D><G><K><P><T><D><F><E><D><L><E><D><G><E><D><L><F><T><S><T><V><S><T><L><E><S><S><P><S><S><P><E><P><A><S><L><P><A><E><D><I><S><A><N><S><N><G><P><K><P><T><E><V><V><L><D><D><D><R><E><D><L><F><A><E><A><T><E><E><V><S><L><D><S><P><E><R><E><P><I><L><S><S><E><P><S><P><A><V><T><P><V><T><P><T><T><L><I><A><P><R><I><E><S><K><S><M><S><A><P><V><I><F><D><R><S><R><E><E><I><E><E><E><A><N><G><D><I><F><D><I><E><I><G><V><S><D><P><E><K><V><G><D><G><M><N><A><Y><M><A><Y><R><V><T><T><K><T><S><L><S><M><F><S><K><S><E><F><S><V><K><R><R><F><S><D><F><L><G><L><H><S><K><L><A><S><K><Y><L><H><V><G><Y><I><V><P><P><A><P><E><K><S><I><V><G><M><T><K><V><K><V><G><K><E><D><S><S><S><T><E><F><V><E><K><R><R><A><A><L><E><R><Y><L><Q><R><T><V><K><H><P><T><L><L><Q><D><P><D><L><R><Q><F><L><E><S><S><E><L><P><R><A><V><N><T><Q><A><L><S><G><A><G><I><L><R><M><V><N><K><A><A><D><A><V><N><K><M><T><I><K><M><N><E><S><D><A><W><F><E><E><K><Q><Q><Q><F><E><N><L><D><Q><Q><L><R><K><L><H><V><S><V><E><A><L><V><C><H><R><K><E><L><S><A><N><T><A><A><F><A><K><S><A><A><M><L><G><N><S><E><D><H><T><A><L><S><R><A><L><S><Q><L><A><E><V><E><E><K><I><D><Q><L><H><Q><E><Q><A><F><A><D><F><Y><M><F><S><E><L><L><S><D><Y><I><R><L><I><A><A><V><K><G><V><F><D><H><R><M><K><C><W><Q><K><W><E><D><A><Q><I><T><L><L><K><K><R><E><A><E><A><K><M><M><V><A><N><K><P><D><K><I><Q><Q><A><K><N><E><I><R><E><W><E><A><K><V><Q><Q><G><E><R><D><F><E><Q><I><S><K><T><I><R><K><E><V><G><R><F><E><K><E><R><V><K><D><F><K><T><V><I><I><K><Y><L><E><S><L><V><Q><T><Q><Q><Q><L><I><K><Y><W><E><A><F><L><P><E><A><K><A><I><A> | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex . The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity . Required for retrograde endosome-to-TGN transport of TGN38 . Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN .<BOP> | O60749 |
Q96LT7 | CI072_HUMAN | Guanine nucleotide exchange factor C9orf72 | Homo | <M><S><T><L><C><P><P><P><S><P><A><V><A><K><T><E><I><A><L><S><G><K><S><P><L><L><A><A><T><F><A><Y><W><D><N><I><L><G><P><R><V><R><H><I><W><A><P><K><T><E><Q><V><L><L><S><D><G><E><I><T><F><L><A><N><H><T><L><N><G><E><I><L><R><N><A><E><S><G><A><I><D><V><K><F><F><V><L><S><E><K><G><V><I><I><V><S><L><I><F><D><G><N><W><N><G><D><R><S><T><Y><G><L><S><I><I><L><P><Q><T><E><L><S><F><Y><L><P><L><H><R><V><C><V><D><R><L><T><H><I><I><R><K><G><R><I><W><M><H><K><E><R><Q><E><N><V><Q><K><I><I><L><E><G><T><E><R><M><E><D><Q><G><Q><S><I><I><P><M><L><T><G><E><V><I><P><V><M><E><L><L><S><S><M><K><S><H><S><V><P><E><E><I><D><I><A><D><T><V><L><N><D><D><D><I><G><D><S><C><H><E><G><F><L><L><N><A><I><S><S><H><L><Q><T><C><G><C><S><V><V><V><G><S><S><A><E><K><V><N><K><I><V><R><T><L><C><L><F><L><T><P><A><E><R><K><C><S><R><L><C><E><A><E><S><S><F><K><Y><E><S><G><L><F><V><Q><G><L><L><K><D><S><T><G><S><F><V><L><P><F><R><Q><V><M><Y><A><P><Y><P><T><T><H><I><D><V><D><V><N><T><V><K><Q><M><P><P><C><H><E><H><I><Y><N><Q><R><R><Y><M><R><S><E><L><T><A><F><W><R><A><T><S><E><E><D><M><A><Q><D><T><I><I><Y><T><D><E><S><F><T><P><D><L><N><I><F><Q><D><V><L><H><R><D><T><L><V><K><A><F><L><D><Q><V><F><Q><L><K><P><G><L><S><L><R><S><T><F><L><A><Q><F><L><L><V><L><H><R><K><A><L><T><L><I><K><Y><I><E><D><D><T><Q><K><G><K><K><P><F><K><S><L><R><N><L><K><I><D><L><D><L><T><A><E><G><D><L><N><I><I><M><A><L><A><E><K><I><K><P><G><L><H><S><F><I><F><G><R><P><F><Y><T><S><V><Q><E><R><D><V><L><M><T><F> | Does not play a role in regulation of stress granule assembly in response to cellular stress.<BOP> | Q96LT7 |
Q8TAC2 | JOS2_HUMAN | Josephin domain-containing protein 2 | Homo | <M><S><Q><A><P><G><A><Q><P><S><P><P><T><V><Y><H><E><R><Q><R><L><E><L><C><A><V><H><A><L><N><N><V><L><Q><Q><Q><L><F><S><Q><E><A><A><D><E><I><C><K><R><L><A><P><D><S><R><L><N><P><H><R><S><L><L><G><T><G><N><Y><D><V><N><V><I><M><A><A><L><Q><G><L><G><L><A><A><V><W><W><D><R><R><R><P><L><S><Q><L><A><L><P><Q><V><L><G><L><I><L><N><L><P><S><P><V><S><L><G><L><L><S><L><P><L><R><R><R><H><W><V><A><L><R><Q><V><D><G><V><Y><Y><N><L><D><S><K><L><R><A><P><E><A><L><G><D><E><D><G><V><R><A><F><L><A><A><A><L><A><Q><G><L><C><E><V><L><L><V><V><T><K><E><V><E><E><K><G><S><W><L><R><T><D> | Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.<BOP> | Q8TAC2 |
Q5GH70 | XKR9_HUMAN | XK-related protein 9, processed form | Homo | <M><K><Y><T><K><Q><N><F><M><M><S><V><L><G><I><I><I><Y><V><T><D><L><I><V><D><I><W><V><S><V><R><F><F><H><E><G><Q><Y><V><F><S><A><L><A><L><S><F><M><L><F><G><T><L><V><A><Q><C><F><S><Y><S><W><F><K><A><D><L><K><K><A><G><Q><E><S><Q><H><C><F><L><L><L><H><C><L><Q><G><G><V><F><T><R><Y><W><F><A><L><K><R><G><Y><H><A><A><F><K><Y><D><S><N><T><S><N><F><V><E><E><Q><I><D><L><H><K><E><V><I><D><R><V><T><D><L><S><M><L><R><L><F><E><T><Y><L><E><G><C><P><Q><L><I><L><Q><L><Y><I><L><L><E><H><G><Q><A><N><F><S><Q><Y><A><A><I><M><V><S><C><C><A><I><S><W><S><T><V><D><Y><Q><V><A><L><R><K><S><L><P><D><K><K><L><L><N><G><L><C><P><K><I><T><Y><L><F><Y><K><L><F><T><L><L><S><W><M><L><S><V><V><L><L><L><F><L><N><V><K><I><A><L><F><L><L><L><F><L><W><L><L><G><I><I><W><A><F><K><N><N><T><Q><F><C><T><C><I><S><M><E><F><L><Y><R><I><V><V><G><F><I><L><I><F><T><F><F><N><I><K><G><Q><N><T><K><C><P><M><S><C><Y><Y><I><V><R><V><L><G><T><L><G><I><L><T><V><F><W><V><C><P><L><T><I><F><N><P><D><Y><F><I><P><I><S><I><T><I><V><L><T><L><L><L><G><I><L><F><L><I><V><Y><Y><G><S><F><H><P><N><R><S><A><E><T><K><C><D><E><I><D><G><K><P><V><L><R><E><C><R><M><R><Y><F><L><M><E> | Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface . Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment .<BOP> | Q5GH70 |
Q30KQ6 | DB114_HUMAN | Defensin, beta 114 | Homo | <M><R><I><F><Y><Y><L><H><F><L><C><Y><V><T><F><I><L><P><A><T><C><T><L><V><N><A><D><R><C><T><K><R><Y><G><R><C><K><R><D><C><L><E><S><E><K><Q><I><D><I><C><S><L><P><R><K><I><C><C><T><E><K><L><Y><E><E><D><D><M><F> | Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality.<BOP> | Q30KQ6 |
O14581 | OR7AH_HUMAN | Olfactory receptor 7A17 | Homo | <M><E><P><E><N><D><T><G><I><S><E><F><V><L><L><G><L><S><E><E><P><E><L><Q><P><F><L><F><G><L><F><L><S><M><Y><L><V><T><V><L><G><N><L><L><I><I><L><A><T><I><S><D><S><H><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><A><D><I><C><F><I><S><T><T><I><P><K><M><L><I><N><I><Q><T><Q><S><R><V><I><T><Y><A><G><C><I><T><Q><M><C><F><F><V><L><F><G><G><L><D><S><L><L><L><A><V><M><A><Y><D><R><F><V><A><I><C><H><P><L><H><Y><T><V><I><M><N><P><R><L><C><G><L><L><V><L><A><S><W><M><I><A><A><L><N><S><L><S><Q><S><L><M><V><L><W><L><S><F><C><T><D><L><E><I><P><H><F><F><C><E><L><N><Q><V><I><H><L><A><C><S><D><T><F><L><N><D><M><G><M><Y><F><A><A><G><L><L><A><G><G><P><L><V><G><I><L><C><S><Y><S><K><I><V><S><S><I><R><A><I><S><S><A><Q><G><K><Y><K><A><F><S><T><C><A><S><H><L><S><V><V><S><L><F><C><C><T><G><L><G><V><Y><L><T><S><A><A><T><H><N><S><H><T><S><A><T><A><S><V><M><Y><T><V><A><T><P><M><L><N><P><F><I><Y><S><L><R><N><K><D><I><K><R><A><L><K><M><S><F><R><G><K><Q> | Odorant receptor.<BOP> | O14581 |
Q9UDY4 | DNJB4_HUMAN | Human liver DnaJ-like protein | Homo | <M><G><K><D><Y><Y><C><I><L><G><I><E><K><G><A><S><D><E><D><I><K><K><A><Y><R><K><Q><A><L><K><F><H><P><D><K><N><K><S><P><Q><A><E><E><K><F><K><E><V><A><E><A><Y><E><V><L><S><D><P><K><K><R><E><I><Y><D><Q><F><G><E><E><G><L><K><G><G><A><G><G><T><D><G><Q><G><G><T><F><R><Y><T><F><H><G><D><P><H><A><T><F><A><A><F><F><G><G><S><N><P><F><E><I><F><F><G><R><R><M><G><G><G><R><D><S><E><E><M><E><I><D><G><D><P><F><S><A><F><G><F><S><M><N><G><Y><P><R><D><R><N><S><V><G><P><S><R><L><K><Q><D><P><P><V><I><H><E><L><R><V><S><L><E><E><I><Y><S><G><C><T><K><R><M><K><I><S><R><K><R><L><N><A><D><G><R><S><Y><R><S><E><D><K><I><L><T><I><E><I><K><K><G><W><K><E><G><T><K><I><T><F><P><R><E><G><D><E><T><P><N><S><I><P><A><D><I><V><F><I><I><K><D><K><D><H><P><K><F><K><R><D><G><S><N><I><I><Y><T><A><K><I><S><L><R><E><A><L><C><G><C><S><I><N><V><P><T><L><D><G><R><N><I><P><M><S><V><N><D><I><V><K><P><G><M><R><R><R><I><I><G><Y><G><L><P><F><P><K><N><P><D><Q><R><G><D><L><L><I><E><F><E><V><S><F><P><D><T><I><S><S><S><S><K><E><V><L><R><K><H><L><P><A><S> | Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) .<BOP> | Q9UDY4 |
Q15077 | P2RY6_HUMAN | P2Y purinoceptor 6 | Homo | <M><E><W><D><N><G><T><G><Q><A><L><G><L><P><P><T><T><C><V><Y><R><E><N><F><K><Q><L><L><L><P><P><V><Y><S><A><V><L><A><A><G><L><P><L><N><I><C><V><I><T><Q><I><C><T><S><R><R><A><L><T><R><T><A><V><Y><T><L><N><L><A><L><A><D><L><L><Y><A><C><S><L><P><L><L><I><Y><N><Y><A><Q><G><D><H><W><P><F><G><D><F><A><C><R><L><V><R><F><L><F><Y><A><N><L><H><G><S><I><L><F><L><T><C><I><S><F><Q><R><Y><L><G><I><C><H><P><L><A><P><W><H><K><R><G><G><R><R><A><A><W><L><V><C><V><A><V><W><L><A><V><T><T><Q><C><L><P><T><A><I><F><A><A><T><G><I><Q><R><N><R><T><V><C><Y><D><L><S><P><P><A><L><A><T><H><Y><M><P><Y><G><M><A><L><T><V><I><G><F><L><L><P><F><A><A><L><L><A><C><Y><C><L><L><A><C><R><L><C><R><Q><D><G><P><A><E><P><V><A><Q><E><R><R><G><K><A><A><R><M><A><V><V><V><A><A><A><F><A><I><S><F><L><P><F><H><I><T><K><T><A><Y><L><A><V><R><S><T><P><G><V><P><C><T><V><L><E><A><F><A><A><A><Y><K><G><T><R><P><F><A><S><A><N><S><V><L><D><P><I><L><F><Y><F><T><Q><K><K><F><R><R><R><P><H><E><L><L><Q><K><L><T><A><K><W><Q><R><Q><G><R> | Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.<BOP> | Q15077 |
O75063 | XYLK_HUMAN | Xylose kinase | Homo | <M><K><L><K><Q><R><V><V><L><L><A><I><L><L><V><I><F><I><F><T><K><V><F><L><I><D><N><L><D><T><S><A><A><N><R><E><D><Q><R><A><F><H><R><M><M><T><G><L><R><V><E><L><A><P><K><L><D><H><T><L><Q><S><P><W><E><I><A><A><Q><W><V><V><P><R><E><V><Y><P><E><E><T><P><E><L><G><A><V><M><H><A><M><A><T><K><K><I><I><K><A><D><V><G><Y><K><G><T><Q><L><K><A><L><L><I><L><E><G><G><Q><K><V><V><F><K><P><K><R><Y><S><R><D><H><V><V><E><G><E><P><Y><A><G><Y><D><R><H><N><A><E><V><A><A><F><H><L><D><R><I><L><G><F><H><R><A><P><L><V><V><G><R><F><V><N><L><R><T><E><I><K><P><V><A><T><E><Q><L><L><S><T><F><L><T><V><G><N><N><T><C><F><Y><G><K><C><Y><Y><C><R><E><T><E><P><A><C><A><D><G><D><I><M><E><G><S><V><T><L><W><L><P><D><V><W><P><L><Q><K><H><R><H><P><W><G><R><T><Y><R><E><G><K><L><A><R><W><E><Y><D><E><S><Y><C><D><A><V><K><K><T><S><P><Y><D><S><G><P><R><L><L><D><I><I><D><T><A><V><F><D><Y><L><I><G><N><A><D><R><H><H><Y><E><S><F><Q><D><D><E><G><A><S><M><L><I><L><L><D><N><A><K><S><F><G><N><P><S><L><D><E><R><S><I><L><A><P><L><Y><Q><C><C><I><I><R><V><S><T><W><N><R><L><N><Y><L><K><N><G><V><L><K><S><A><L><K><S><A><M><A><H><D><P><I><S><P><V><L><S><D><P><H><L><D><A><V><D><Q><R><L><L><S><V><L><A><T><V><K><Q><C><T><D><Q><F><G><M><D><T><V><L><V><E><D><R><M><P><L><S><H><L> | Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.<BOP> | O75063 |
P06870 | KLK1_HUMAN | Tissue kallikrein | Homo | <M><W><F><L><V><L><C><L><A><L><S><L><G><G><T><G><A><A><P><P><I><Q><S><R><I><V><G><G><W><E><C><E><Q><H><S><Q><P><W><Q><A><A><L><Y><H><F><S><T><F><Q><C><G><G><I><L><V><H><R><Q><W><V><L><T><A><A><H><C><I><S><D><N><Y><Q><L><W><L><G><R><H><N><L><F><D><D><E><N><T><A><Q><F><V><H><V><S><E><S><F><P><H><P><G><F><N><M><S><L><L><E><N><H><T><R><Q><A><D><E><D><Y><S><H><D><L><M><L><L><R><L><T><E><P><A><D><T><I><T><D><A><V><K><V><V><E><L><P><T><E><E><P><E><V><G><S><T><C><L><A><S><G><W><G><S><I><E><P><E><N><F><S><F><P><D><D><L><Q><C><V><D><L><K><I><L><P><N><D><E><C><K><K><A><H><V><Q><K><V><T><D><F><M><L><C><V><G><H><L><E><G><G><K><D><T><C><V><G><D><S><G><G><P><L><M><C><D><G><V><L><Q><G><V><T><S><W><G><Y><V><P><C><G><T><P><N><K><P><S><V><A><V><R><V><L><S><Y><V><K><W><I><E><D><T><I><A><E><N><S> | Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.<BOP> | P06870 |
Q3ZCM7 | TBB8_HUMAN | Tubulin beta 8 class VIII | Homo | <M><R><E><I><V><L><T><Q><I><G><Q><C><G><N><Q><I><G><A><K><F><W><E><V><I><S><D><E><H><A><I><D><S><A><G><T><Y><H><G><D><S><H><L><Q><L><E><R><I><N><V><Y><Y><N><E><A><S><G><G><R><Y><V><P><R><A><V><L><V><D><L><E><P><G><T><M><D><S><V><R><S><G><P><F><G><Q><V><F><R><P><D><N><F><I><F><G><Q><C><G><A><G><N><N><W><A><K><G><H><Y><T><E><G><A><E><L><M><E><S><V><M><D><V><V><R><K><E><A><E><S><C><D><C><L><Q><G><F><Q><L><T><H><S><L><G><G><G><T><G><S><G><M><G><T><L><L><L><S><K><I><R><E><E><Y><P><D><R><I><I><N><T><F><S><I><L><P><S><P><K><V><S><D><T><V><V><E><P><Y><N><A><T><L><S><V><H><Q><L><I><E><N><A><D><E><T><F><C><I><D><N><E><A><L><Y><D><I><C><S><K><T><L><K><L><P><T><P><T><Y><G><D><L><N><H><L><V><S><A><T><M><S><G><V><T><T><C><L><R><F><P><G><Q><L><N><A><D><L><R><K><L><A><V><N><M><V><P><F><P><R><L><H><F><F><M><P><G><F><A><P><L><T><S><R><G><S><Q><Q><Y><R><A><L><T><V><A><E><L><T><Q><Q><M><F><D><A><K><N><M><M><A><A><C><D><P><R><H><G><R><Y><L><T><A><A><A><I><F><R><G><R><M><P><M><R><E><V><D><E><Q><M><F><N><I><Q><D><K><N><S><S><Y><F><A><D><W><L><P><N><N><V><K><T><A><V><C><D><I><P><P><R><G><L><K><M><S><A><T><F><I><G><N><N><T><A><I><Q><E><L><F><K><R><V><S><E><Q><F><T><A><M><F><R><R><K><A><F><L><H><W><Y><T><G><E><G><M><D><E><M><E><F><T><E><A><E><S><N><M><N><D><L><V><S><E><Y><Q><Q><Y><Q><D><A><T><A><E><E><E><E><D><E><E><Y><A><E><E><E><V><A> | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation .<BOP> | Q3ZCM7 |
O15130 | NPFF_HUMAN | Neuropeptide AF | Homo | <M><D><S><R><Q><A><A><A><L><L><V><L><L><L><L><I><D><G><G><C><A><E><G><P><G><G><Q><Q><E><D><Q><L><S><A><E><E><D><S><E><P><L><P><P><Q><D><A><Q><T><S><G><S><L><L><H><Y><L><L><Q><A><M><E><R><P><G><R><S><Q><A><F><L><F><Q><P><Q><R><F><G><R><N><T><Q><G><S><W><R><N><E><W><L><S><P><R><A><G><E><G><L><N><S><Q><F><W><S><L><A><A><P><Q><R><F><G><K><K> | Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.<BOP> | O15130 |
P35610 | SOAT1_HUMAN | Cholesterol acyltransferase 1 | Homo | <M><V><G><E><E><K><M><S><L><R><N><R><L><S><K><S><R><E><N><P><E><E><D><E><D><Q><R><N><P><A><K><E><S><L><E><T><P><S><N><G><R><I><D><I><K><Q><L><I><A><K><K><I><K><L><T><A><E><A><E><E><L><K><P><F><F><M><K><E><V><G><S><H><F><D><D><F><V><T><N><L><I><E><K><S><A><S><L><D><N><G><G><C><A><L><T><T><F><S><V><L><E><G><E><K><N><N><H><R><A><K><D><L><R><A><P><P><E><Q><G><K><I><F><I><A><R><R><S><L><L><D><E><L><L><E><V><D><H><I><R><T><I><Y><H><M><F><I><A><L><L><I><L><F><I><L><S><T><L><V><V><D><Y><I><D><E><G><R><L><V><L><E><F><S><L><L><S><Y><A><F><G><K><F><P><T><V><V><W><T><W><W><I><M><F><L><S><T><F><S><V><P><Y><F><L><F><Q><H><W><A><T><G><Y><S><K><S><S><H><P><L><I><R><S><L><F><H><G><F><L><F><M><I><F><Q><I><G><V><L><G><F><G><P><T><Y><V><V><L><A><Y><T><L><P><P><A><S><R><F><I><I><I><F><E><Q><I><R><F><V><M><K><A><H><S><F><V><R><E><N><V><P><R><V><L><N><S><A><K><E><K><S><S><T><V><P><I><P><T><V><N><Q><Y><L><Y><F><L><F><A><P><T><L><I><Y><R><D><S><Y><P><R><N><P><T><V><R><W><G><Y><V><A><M><K><F><A><Q><V><F><G><C><F><F><Y><V><Y><Y><I><F><E><R><L><C><A><P><L><F><R><N><I><K><Q><E><P><F><S><A><R><V><L><V><L><C><V><F><N><S><I><L><P><G><V><L><I><L><F><L><T><F><F><A><F><L><H><C><W><L><N><A><F><A><E><M><L><R><F><G><D><R><M><F><Y><K><D><W><W><N><S><T><S><Y><S><N><Y><Y><R><T><W><N><V><V><V><H><D><W><L><Y><Y><Y><A><Y><K><D><F><L><W><F><F><S><K><R><F><K><S><A><A><M><L><A><V><F><A><V><S><A><V><V><H><E><Y><A><L><A><V><C><L><S><F><F><Y><P><V><L><F><V><L><F><M><F><F><G><M><A><F><N><F><I><V><N><D><S><R><K><K><P><I><W><N><V><L><M><W><T><S><L><F><L><G><N><G><V><L><L><C><F><Y><S><Q><E><W><Y><A><R><Q><H><C><P><L><K><N><P><T><F><L><D><Y><V><R><P><R><S><W><T><C><R><Y><V><F> | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol . Plays a role in lipoprotein assembly and dietary cholesterol absorption . Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions .<BOP> | P35610 |
Q9UNP9 | PPIE_HUMAN | Rotamase E | Homo | <M><A><T><T><K><R><V><L><Y><V><G><G><L><A><E><E><V><D><D><K><V><L><H><A><A><F><I><P><F><G><D><I><T><D><I><Q><I><P><L><D><Y><E><T><E><K><H><R><G><F><A><F><V><E><F><E><L><A><E><D><A><A><A><A><I><D><N><M><N><E><S><E><L><F><G><R><T><I><R><V><N><L><A><K><P><M><R><I><K><E><G><S><S><R><P><V><W><S><D><D><D><W><L><K><K><F><S><G><K><T><L><E><E><N><K><E><E><E><G><S><E><P><P><K><A><E><T><Q><E><G><E><P><I><A><K><K><A><R><S><N><P><Q><V><Y><M><D><I><K><I><G><N><K><P><A><G><R><I><Q><M><L><L><R><S><D><V><V><P><M><T><A><E><N><F><R><C><L><C><T><H><E><K><G><F><G><F><K><G><S><S><F><H><R><I><I><P><Q><F><M><C><Q><G><G><D><F><T><N><H><N><G><T><G><G><K><S><I><Y><G><K><K><F><D><D><E><N><F><I><L><K><H><T><G><P><G><L><L><S><M><A><N><S><G><P><N><T><N><G><S><Q><F><F><L><T><C><D><K><T><D><W><L><D><G><K><H><V><V><F><G><E><V><T><E><G><L><D><V><L><R><Q><I><E><A><Q><G><S><K><D><G><K><P><K><Q><K><V><I><I><A><D><C><G><E><Y><V> | Involved in pre-mRNA splicing as component of the spliceosome . Combines RNA-binding and PPIase activities . Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules . Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins . Inhibits KMT2A activity; this requires proline isomerase activity .<BOP> | Q9UNP9 |
Q9NYA1 | SPHK1_HUMAN | Acetyltransferase SPHK1 | Homo | <M><D><P><A><G><G><P><R><G><V><L><P><R><P><C><R><V><L><V><L><L><N><P><R><G><G><K><G><K><A><L><Q><L><F><R><S><H><V><Q><P><L><L><A><E><A><E><I><S><F><T><L><M><L><T><E><R><R><N><H><A><R><E><L><V><R><S><E><E><L><G><R><W><D><A><L><V><V><M><S><G><D><G><L><M><H><E><V><V><N><G><L><M><E><R><P><D><W><E><T><A><I><Q><K><P><L><C><S><L><P><A><G><S><G><N><A><L><A><A><S><L><N><H><Y><A><G><Y><E><Q><V><T><N><E><D><L><L><T><N><C><T><L><L><L><C><R><R><L><L><S><P><M><N><L><L><S><L><H><T><A><S><G><L><R><L><F><S><V><L><S><L><A><W><G><F><I><A><D><V><D><L><E><S><E><K><Y><R><R><L><G><E><M><R><F><T><L><G><T><F><L><R><L><A><A><L><R><T><Y><R><G><R><L><A><Y><L><P><V><G><R><V><G><S><K><T><P><A><S><P><V><V><V><Q><Q><G><P><V><D><A><H><L><V><P><L><E><E><P><V><P><S><H><W><T><V><V><P><D><E><D><F><V><L><V><L><A><L><L><H><S><H><L><G><S><E><M><F><A><A><P><M><G><R><C><A><A><G><V><M><H><L><F><Y><V><R><A><G><V><S><R><A><M><L><L><R><L><F><L><A><M><E><K><G><R><H><M><E><Y><E><C><P><Y><L><V><Y><V><P><V><V><A><F><R><L><E><P><K><D><G><K><G><V><F><A><V><D><G><E><L><M><V><S><E><A><V><Q><G><Q><V><H><P><N><Y><F><W><M><V><S><G><C><V><E><P><P><P><S><W><K><P><Q><Q><M><P><P><P><E><E><P><L> | Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.<BOP> | Q9NYA1 |
Q8NGZ2 | O14K1_HUMAN | Olfactory receptor OR1-39 | Homo | <M><T><N><Q><T><Q><M><M><E><F><L><L><V><R><F><T><E><N><W><V><L><L><R><L><H><A><L><L><F><S><L><I><Y><L><T><A><V><L><M><N><L><V><I><I><L><L><M><I><L><D><H><R><L><H><M><A><M><Y><F><F><L><R><H><L><S><F><L><D><L><C><L><I><S><A><T><V><P><K><S><I><L><N><S><V><A><S><T><D><S><I><S><F><L><G><C><V><L><Q><L><F><L><V><V><L><L><A><G><S><E><I><G><I><L><T><A><M><S><Y><D><R><Y><A><A><I><C><C><P><L><H><C><E><A><V><M><S><R><G><L><C><V><Q><L><M><A><L><S><W><L><N><R><G><A><L><G><L><L><Y><T><A><G><T><F><S><L><N><F><Y><G><S><D><E><L><H><Q><F><F><C><D><V><P><A><L><L><K><L><T><C><S><K><E><H><A><I><I><S><V><S><V><A><I><G><V><C><Y><A><F><S><C><L><V><C><I><V><V><S><Y><V><Y><I><F><S><A><V><L><R><I><S><Q><R><Q><R><Q><S><K><A><F><S><N><C><V><P><H><L><I><V><V><T><V><F><L><V><T><G><A><V><A><Y><L><K><P><G><S><D><A><P><S><I><L><D><L><L><V><S><V><F><Y><S><V><A><P><P><T><L><N><P><V><I><Y><C><L><K><N><K><D><I><K><S><A><L><S><K><V><L><W><N><V><R><S><S><G><V><M><K><R> | Odorant receptor.<BOP> | Q8NGZ2 |
P05455 | LA_HUMAN | Sjoegren syndrome type B antigen | Homo | <M><A><E><N><G><D><N><E><K><M><A><A><L><E><A><K><I><C><H><Q><I><E><Y><Y><F><G><D><F><N><L><P><R><D><K><F><L><K><E><Q><I><K><L><D><E><G><W><V><P><L><E><I><M><I><K><F><N><R><L><N><R><L><T><T><D><F><N><V><I><V><E><A><L><S><K><S><K><A><E><L><M><E><I><S><E><D><K><T><K><I><R><R><S><P><S><K><P><L><P><E><V><T><D><E><Y><K><N><D><V><K><N><R><S><V><Y><I><K><G><F><P><T><D><A><T><L><D><D><I><K><E><W><L><E><D><K><G><Q><V><L><N><I><Q><M><R><R><T><L><H><K><A><F><K><G><S><I><F><V><V><F><D><S><I><E><S><A><K><K><F><V><E><T><P><G><Q><K><Y><K><E><T><D><L><L><I><L><F><K><D><D><Y><F><A><K><K><N><E><E><R><K><Q><N><K><V><E><A><K><L><R><A><K><Q><E><Q><E><A><K><Q><K><L><E><E><D><A><E><M><K><S><L><E><E><K><I><G><C><L><L><K><F><S><G><D><L><D><D><Q><T><C><R><E><D><L><H><I><L><F><S><N><H><G><E><I><K><W><I><D><F><V><R><G><A><K><E><G><I><I><L><F><K><E><K><A><K><E><A><L><G><K><A><K><D><A><N><N><G><N><L><Q><L><R><N><K><E><V><T><W><E><V><L><E><G><E><V><E><K><E><A><L><K><K><I><I><E><D><Q><Q><E><S><L><N><K><W><K><S><K><G><R><R><F><K><G><K><G><K><G><N><K><A><A><Q><P><G><S><G><K><G><K><V><Q><F><Q><G><K><K><T><K><F><A><S><D><D><E><H><D><E><H><D><E><N><G><A><T><G><P><V><K><R><A><R><E><E><T><D><K><E><E><P><A><S><K><Q><Q><K><T><E><N><G><A><G><D><Q> | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation . In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation .<BOP> | P05455 |
Q9BR39 | JPH2_HUMAN | Junctophilin-2 N-terminal fragment | Homo | <M><S><G><G><R><F><D><F><D><D><G><G><A><Y><C><G><G><W><E><G><G><K><A><H><G><H><G><L><C><T><G><P><K><G><Q><G><E><Y><S><G><S><W><N><F><G><F><E><V><A><G><V><Y><T><W><P><S><G><N><T><F><E><G><Y><W><S><Q><G><K><R><H><G><L><G><I><E><T><K><G><R><W><L><Y><K><G><E><W><T><H><G><F><K><G><R><Y><G><I><R><Q><S><S><S><S><G><A><K><Y><E><G><T><W><N><N><G><L><Q><D><G><Y><G><T><E><T><Y><A><D><G><G><T><Y><Q><G><Q><F><T><N><G><M><R><H><G><Y><G><V><R><Q><S><V><P><Y><G><M><A><V><V><V><R><S><P><L><R><T><S><L><S><S><L><R><S><E><H><S><N><G><T><V><A><P><D><S><P><A><S><P><A><S><D><G><P><A><L><P><S><P><A><I><P><R><G><G><F><A><L><S><L><L><A><N><A><E><A><A><A><R><A><P><K><G><G><G><L><F><Q><R><G><A><L><L><G><K><L><R><R><A><E><S><R><T><S><V><G><S><Q><R><S><R><V><S><F><L><K><S><D><L><S><S><G><A><S><D><A><A><S><T><A><S><L><G><E><A><A><E><G><A><D><E><A><A><P><F><E><A><D><I><D><A><T><T><T><E><T><Y><M><G><E><W><K><N><D><K><R><S><G><F><G><V><S><E><R><S><S><G><L><R><Y><E><G><E><W><L><D><N><L><R><H><G><Y><G><C><T><T><L><P><D><G><H><R><E><E><G><K><Y><R><H><N><V><L><V><K><D><T><K><R><R><M><L><Q><L><K><S><N><K><V><R><Q><K><V><E><H><S><V><E><G><A><Q><R><A><A><A><I><A><R><Q><K><A><E><I><A><A><S><R><T><S><H><A><K><A><K><A><E><A><A><E><Q><A><A><L><A><A><N><Q><E><S><N><I><A><R><T><L><A><R><E><L><A><P><D><F><Y><Q><P><G><P><E><Y><Q><K><R><R><L><L><Q><E><I><L><E><N><S><E><S><L><L><E><P><P><D><R><G><A><G><A><A><G><L><P><Q><P><P><R><E><S><P><Q><L><H><E><R><E><T><P><R><P><E><G><G><S><P><S><P><A><G><T><P><P><Q><P><K><R><P><R><P><G><V><S><K><D><G><L><L><S><P><G><A><W><N><G><E><P><S><G><E><G><S><R><S><V><T><P><S><E><G><A><G><R><R><S><P><A><R><P><A><T><E><R><M><A><I><E><A><L><Q><A><P><P><A><P><S><R><E><P><E><V><A><L><Y><Q><G><Y><H><S><Y><A><V><R><T><T><P><P><E><P><P><P><F><E><D><Q><P><E><P><E><V><S><G><S><E><S><A><P><S><S><P><A><T><A><P><L><Q><A><P><T><L><R><G><P><E><P><A><R><E><T><P><A><K><L><E><P><K><P><I><I><P><K><A><E><P><R><A><K><A><R><K><T><E><A><R><G><L><T><K><A><G><A><K><K><K><A><R><K><E><A><A><L><A><A><E><A><E><V><E><V><E><E><V><P><N><T><I><L><I><C><M><V><I><L><L><N><I><G><L><A><I><L><F><V><H><L><L><T> | Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.<BOP> | Q9BR39 |
Q01453 | PMP22_HUMAN | Growth arrest-specific protein 3 | Homo | <M><L><L><L><L><L><S><I><I><V><L><H><V><A><V><L><V><L><L><F><V><S><T><I><V><S><Q><W><I><V><G><N><G><H><A><T><D><L><W><Q><N><C><S><T><S><S><S><G><N><V><H><H><C><F><S><S><S><P><N><E><W><L><Q><S><V><Q><A><T><M><I><L><S><I><I><F><S><I><L><S><L><F><L><F><F><C><Q><L><F><T><L><T><K><G><G><R><F><Y><I><T><G><I><F><Q><I><L><A><G><L><C><V><M><S><A><A><A><I><Y><T><V><R><H><P><E><W><H><L><N><S><D><Y><S><Y><G><F><A><Y><I><L><A><W><V><A><F><P><L><A><L><L><S><G><V><I><Y><V><I><L><R><K><R><E> | Might be involved in growth regulation, and in myelinization in the peripheral nervous system.<BOP> | Q01453 |
Q9NZ53 | PDXL2_HUMAN | Endoglycan | Homo | <M><G><R><L><L><R><A><A><R><L><P><P><L><L><S><P><L><L><L><L><L><V><G><G><A><F><L><G><A><C><V><A><G><S><D><E><P><G><P><E><G><L><T><S><T><S><L><L><D><L><L><L><P><T><G><L><E><P><L><D><S><E><E><P><S><E><T><M><G><L><G><A><G><L><G><A><P><G><S><G><F><P><S><E><E><N><E><E><S><R><I><L><Q><P><P><Q><Y><F><W><E><E><E><E><E><L><N><D><S><S><L><D><L><G><P><T><A><D><Y><V><F><P><D><L><T><E><K><A><G><S><I><E><D><T><S><Q><A><Q><E><L><P><N><L><P><S><P><L><P><K><M><N><L><V><E><P><P><W><H><M><P><P><R><E><E><E><E><E><E><E><E><E><E><E><R><E><K><E><E><V><E><K><Q><E><E><E><E><E><E><E><L><L><P><V><N><G><S><Q><E><E><A><K><P><Q><V><R><D><F><S><L><T><S><S><S><Q><T><P><G><A><T><K><S><R><H><E><D><S><G><D><Q><A><S><S><G><V><E><V><E><S><S><M><G><P><S><L><L><L><P><S><V><T><P><T><T><V><T><P><G><D><Q><D><S><T><S><Q><E><A><E><A><T><V><L><P><A><A><G><L><G><V><E><F><E><A><P><Q><E><A><S><E><E><A><T><A><G><A><A><G><L><S><G><Q><H><E><E><V><P><A><L><P><S><F><P><Q><T><T><A><P><S><G><A><E><H><P><D><E><D><P><L><G><S><R><T><S><A><S><S><P><L><A><P><G><D><M><E><L><T><P><S><S><A><T><L><G><Q><E><D><L><N><Q><Q><L><L><E><G><Q><A><A><E><A><Q><S><R><I><P><W><D><S><T><Q><V><I><C><K><D><W><S><N><L><A><G><K><N><Y><I><I><L><N><M><T><E><N><I><D><C><E><V><F><R><Q><H><R><G><P><Q><L><L><A><L><V><E><E><V><L><P><R><H><G><S><G><H><H><G><A><W><H><I><S><L><S><K><P><S><E><K><E><Q><H><L><L><M><T><L><V><G><E><Q><G><V><V><P><T><Q><D><V><L><S><M><L><G><D><I><R><R><S><L><E><E><I><G><I><Q><N><Y><S><T><T><S><S><C><Q><A><R><A><S><Q><V><R><S><D><Y><G><T><L><F><V><V><L><V><V><I><G><A><I><C><I><I><I><I><A><L><G><L><L><Y><N><C><W><Q><R><R><L><P><K><L><K><H><V><S><H><G><E><E><L><R><F><V><E><N><G><C><H><D><N><P><T><L><D><V><A><S><D><S><Q><S><E><M><Q><E><K><H><P><S><L><N><G><G><G><A><L><N><G><P><G><S><W><G><A><L><M><G><G><K><R><D><P><E><D><S><D><V><F><E><E><D><T><H><L> | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins.<BOP> | Q9NZ53 |
Q15120 | PDK3_HUMAN | Pyruvate dehydrogenase kinase isoform 3 | Homo | <M><R><L><F><R><W><L><L><K><Q><P><V><P><K><Q><I><E><R><Y><S><R><F><S><P><S><P><L><S><I><K><Q><F><L><D><F><G><R><D><N><A><C><E><K><T><S><Y><M><F><L><R><K><E><L><P><V><R><L><A><N><T><M><R><E><V><N><L><L><P><D><N><L><L><N><R><P><S><V><G><L><V><Q><S><W><Y><M><Q><S><F><L><E><L><L><E><Y><E><N><K><S><P><E><D><P><Q><V><L><D><N><F><L><Q><V><L><I><K><V><R><N><R><H><N><D><V><V><P><T><M><A><Q><G><V><I><E><Y><K><E><K><F><G><F><D><P><F><I><S><T><N><I><Q><Y><F><L><D><R><F><Y><T><N><R><I><S><F><R><M><L><I><N><Q><H><T><L><L><F><G><G><D><T><N><P><V><H><P><K><H><I><G><S><I><D><P><T><C><N><V><A><D><V><V><K><D><A><Y><E><T><A><K><M><L><C><E><Q><Y><Y><L><V><A><P><E><L><E><V><E><E><F><N><A><K><A><P><D><K><P><I><Q><V><V><Y><V><P><S><H><L><F><H><M><L><F><E><L><F><K><N><S><M><R><A><T><V><E><L><Y><E><D><R><K><E><G><Y><P><A><V><K><T><L><V><T><L><G><K><E><D><L><S><I><K><I><S><D><L><G><G><G><V><P><L><R><K><I><D><R><L><F><N><Y><M><Y><S><T><A><P><R><P><S><L><E><P><T><R><A><A><P><L><A><G><F><G><Y><G><L><P><I><S><R><L><Y><A><R><Y><F><Q><G><D><L><K><L><Y><S><M><E><G><V><G><T><D><A><V><I><Y><L><K><A><L><S><S><E><S><F><E><R><L><P><V><F><N><K><S><A><W><R><H><Y><K><T><T><P><E><A><D><D><W><S><N><P><S><S><E><P><R><D><A><S><K><Y><K><A><K><Q> | Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.<BOP> | Q15120 |
Q5T197 | DCST1_HUMAN | RING-type E3 ubiquitin transferase | Homo | <M><D><I><K><H><H><Q><N><G><T><R><G><Q><R><R><K><Q><P><H><T><T><V><Q><R><L><L><T><W><G><L><P><V><S><C><S><W><F><L><W><R><Q><P><G><E><F><P><V><T><A><L><L><L><G><A><G><A><G><G><L><L><A><I><G><L><F><Q><L><L><V><N><P><M><N><I><Y><E><E><Q><K><I><M><F><L><Y><S><L><V><G><L><G><A><M><G><W><G><T><S><P><H><I><R><C><A><S><L><L><L><V><P><K><M><L><G><K><E><G><R><L><F><V><L><G><Y><A><L><A><A><I><Y><V><G><P><V><A><N><L><R><H><N><L><N><N><V><I><A><S><L><G><C><T><V><E><L><Q><I><N><N><T><R><A><A><W><R><I><S><T><A><P><L><R><A><M><F><K><D><L><L><S><S><K><E><L><L><R><A><E><T><R><N><I><S><A><T><F><E><D><L><D><A><Q><V><N><S><E><T><G><Y><T><P><E><D><T><M><D><S><G><E><T><A><Q><G><R><E><A><R><Q><A><P><A><S><R><L><H><L><S><T><Q><K><M><Y><E><L><K><T><K><L><R><C><S><Y><V><V><N><Q><A><I><L><S><C><R><R><W><F><D><R><K><H><E><Q><C><M><K><H><I><W><V><P><L><L><T><H><L><L><C><L><P><M><K><F><K><F><F><C><G><I><A><K><V><M><E><V><W><C><R><N><R><I><P><V><E><G><N><F><G><Q><T><Y><D><S><L><N><Q><S><I><R><G><L><D><G><E><F><S><A><N><I><D><F><K><E><E><K><Q><A><G><V><L><G><L><N><T><S><W><E><R><V><S><T><E><V><R><D><Y><V><Y><R><Q><E><A><R><L><E><W><A><L><G><L><L><H><V><L><L><S><C><T><F><L><L><V><L><H><A><S><F><S><Y><M><D><S><Y><N><H><D><I><R><F><D><N><I><Y><I><S><T><Y><F><C><Q><I><D><D><R><R><K><K><L><G><K><R><T><L><L><P><L><R><K><A><E><E><K><T><V><I><F><P><C><K><P><T><I><Q><A><S><E><M><S><N><V><V><R><E><L><L><E><T><L><P><I><L><L><L><L><V><V><L><C><G><L><D><W><A><L><Y><S><I><F><D><T><I><R><H><H><S><F><L><Q><Y><S><F><R><S><S><H><K><L><E><V><K><V><G><G><D><S><M><L><A><R><L><L><R><K><T><I><G><A><L><N><T><S><S><E><T><V><M><E><S><N><N><M><P><C><L><P><Q><P><V><G><L><D><A><R><A><Y><W><R><A><A><V><P><I><G><L><L><V><C><L><C><L><L><Q><A><F><G><Y><R><L><R><R><V><I><A><A><F><Y><F><P><K><R><E><K><K><R><I><L><F><L><Y><N><D><L><L><K><K><R><A><A><F><T><K><L><R><R><A><A><I><L><R><R><E><R><Q><Q><K><A><P><R><H><P><L><A><D><I><L><H><R><G><C><P><L><L><R><R><W><L><C><R><R><C><V><V><C><Q><A><P><E><T><P><E><S><Y><V><C><R><T><L><D><C><E><A><V><Y><C><W><S><C><W><D><D><M><R><Q><R><C><P><V><C><T><P><R><E><E><L><S><S><S><A><F><S><D><S><N><D><D><T><A><Y><A><G> | E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.<BOP> | Q5T197 |
A6NDB9 | PALM3_HUMAN | Paralemmin-3 | Homo | <M><A><E><S><S><L><Y><R><Q><R><L><E><V><I><A><E><K><R><R><L><Q><E><E><I><R><A><A><R><R><E><V><E><E><E><K><L><R><V><E><R><L><K><R><K><S><L><R><E><R><W><L><M><D><G><A><A><A><V><P><E><P><S><E><D><P><T><S><K><D><P><Q><S><P><E><G><Q><A><Q><A><R><I><R><N><L><E><D><S><L><F><T><L><Q><S><Q><L><Q><L><L><Q><S><A><S><T><G><A><Q><H><K><P><S><G><R><P><S><W><R><R><Q><G><H><R><P><L><S><Q><S><I><V><E><A><G><S><V><G><Q><T><D><L><N><K><R><A><S><L><P><A><G><L><V><G><T><P><P><E><S><P><S><E><P><R><E><D><V><L><G><F><L><P><G><P><R><Q><V><P><G><A><A><G><D><S><S><E><A><N><G><P><C><P><S><P><I><P><T><P><E><Q><G><L><S><Q><R><A><V><P><S><E><G><R><V><G><E><A><K><G><G><G><V><V><S><V><V><W><E><G><L><R><A><T><E><D><C><A><T><G><A><T><G><P><E><L><E><A><K><V><E><E><V><V><L><E><A><I><G><D><R><K><G><A><G><S><L><E><L><P><A><W><V><K><E><D><R><G><I><V><E><V><V><W><E><G><V><G><G><S><D><A><E><A><M><G><E><I><G><R><V><P><E><V><V><Q><T><S><S><P><R><L><Q><E><R><L><E><A><A><A><S><I><E><G><E><D><V><P><Q><G><S><P><E><G><D><G><Q><G><G><S><G><G><E><E><G><S><F><I><W><V><E><R><V><T><L><S><E><E><W><E><E><L><L><V><E><G><L><E><G><P><E><V><A><G><R><E><R><G><D><E><S><P><L><G><A><E><G><A><K><T><G><G><G><E><E><T><W><E><A><E><K><R><K><A><E><E><S><M><G><I><G><S><E><E><K><P><G><T><G><R><D><E><A><E><M><S><P><V><V><E><R><K><G><G><E><K><K><L><E><L><E><S><R><G><S><A><E><K><L><G><T><E><R><E><G><G><E><E><P><L><G><I><E><R><K><V><E><G><H><L><R><A><E><K><E><G><D><E><E><K><R><G><A><E><E><E><E><V><E><E><P><L><G><V><E><K><K><G><G><E><E><E><P><E><A><T><K><E><P><L><E><A><E><R><K><G><G><E><E><T><L><E><A><E><K><R><G><G><E><E><S><L><E><T><E><K><T><Q><G><T><E><G><D><L><N><L><E><Q><G><S><R><E><G><S><E><S><Q><A><E><E><M><N><E><A><G><P><P><L><E><A><N><T><E><T><R><P><E><K><E><G><P><Q><P><Q><E><K><P><V><G><A><L><E><E><E><G><V><K><P><Q><T><A><A><E><G><Q><G><P><L><G><D><A><T><P><L><L><A><E><T><P><A><P><E><Q><P><A><E><C><Q><P><L><L><Q><G><E><G><P><S><A><N><P><S><A><H><P><V><P><T><Y><A><P><A><R><Q><P><E><P><S><A><P><T><E><G><E><E><A><S><G><P><K><Q><K><T><C><Q><C><C><A><V><M> | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling.<BOP> | A6NDB9 |
Q8IXK2 | GLT12_HUMAN | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12 | Homo | <M><W><G><R><T><A><R><R><R><C><P><R><E><L><R><R><G><R><E><A><L><L><V><L><L><A><L><L><A><L><A><G><L><G><S><V><L><R><A><Q><R><G><A><G><A><G><A><A><E><P><G><P><P><R><T><P><R><P><G><R><R><E><P><V><M><P><R><P><P><V><P><A><N><A><L><G><A><R><G><E><A><V><R><L><Q><L><Q><G><E><E><L><R><L><Q><E><E><S><V><R><L><H><Q><I><N><I><Y><L><S><D><R><I><S><L><H><R><R><L><P><E><R><W><N><P><L><C><K><E><K><K><Y><D><Y><D><N><L><P><R><T><S><V><I><I><A><F><Y><N><E><A><W><S><T><L><L><R><T><V><Y><S><V><L><E><T><S><P><D><I><L><L><E><E><V><I><L><V><D><D><Y><S><D><R><E><H><L><K><E><R><L><A><N><E><L><S><G><L><P><K><V><R><L><I><R><A><N><K><R><E><G><L><V><R><A><R><L><L><G><A><S><A><A><R><G><D><V><L><T><F><L><D><C><H><C><E><C><H><E><G><W><L><E><P><L><L><Q><R><I><H><E><E><E><S><A><V><V><C><P><V><I><D><V><I><D><W><N><T><F><E><Y><L><G><N><S><G><E><P><Q><I><G><G><F><D><W><R><L><V><F><T><W><H><T><V><P><E><R><E><R><I><R><M><Q><S><P><V><D><V><I><R><S><P><T><M><A><G><G><L><F><A><V><S><K><K><Y><F><E><Y><L><G><S><Y><D><T><G><M><E><V><W><G><G><E><N><L><E><F><S><F><R><I><W><Q><C><G><G><V><L><E><T><H><P><C><S><H><V><G><H><V><F><P><K><Q><A><P><Y><S><R><N><K><A><L><A><N><S><V><R><A><A><E><V><W><M><D><E><F><K><E><L><Y><Y><H><R><N><P><R><A><R><L><E><P><F><G><D><V><T><E><R><K><Q><L><R><D><K><L><Q><C><K><D><F><K><W><F><L><E><T><V><Y><P><E><L><H><V><P><E><D><R><P><G><F><F><G><M><L><Q><N><K><G><L><T><D><Y><C><F><D><Y><N><P><P><D><E><N><Q><I><V><G><H><Q><V><I><L><Y><L><C><H><G><M><G><Q><N><Q><F><F><E><Y><T><S><Q><K><E><I><R><Y><N><T><H><Q><P><E><G><C><I><A><V><E><A><G><M><D><T><L><I><M><H><L><C><E><E><T><A><P><E><N><Q><K><F><I><L><Q><E><D><G><S><L><F><H><E><Q><S><K><K><C><V><Q><A><A><R><K><E><S><S><D><S><F><V><P><L><L><R><D><C><T><N><S><D><H><Q><K><W><F><F><K><E><R><M><L> | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.<BOP> | Q8IXK2 |
P09237 | MMP7_HUMAN | Uterine metalloproteinase | Homo | <M><R><L><T><V><L><C><A><V><C><L><L><P><G><S><L><A><L><P><L><P><Q><E><A><G><G><M><S><E><L><Q><W><E><Q><A><Q><D><Y><L><K><R><F><Y><L><Y><D><S><E><T><K><N><A><N><S><L><E><A><K><L><K><E><M><Q><K><F><F><G><L><P><I><T><G><M><L><N><S><R><V><I><E><I><M><Q><K><P><R><C><G><V><P><D><V><A><E><Y><S><L><F><P><N><S><P><K><W><T><S><K><V><V><T><Y><R><I><V><S><Y><T><R><D><L><P><H><I><T><V><D><R><L><V><S><K><A><L><N><M><W><G><K><E><I><P><L><H><F><R><K><V><V><W><G><T><A><D><I><M><I><G><F><A><R><G><A><H><G><D><S><Y><P><F><D><G><P><G><N><T><L><A><H><A><F><A><P><G><T><G><L><G><G><D><A><H><F><D><E><D><E><R><W><T><D><G><S><S><L><G><I><N><F><L><Y><A><A><T><H><E><L><G><H><S><L><G><M><G><H><S><S><D><P><N><A><V><M><Y><P><T><Y><G><N><G><D><P><Q><N><F><K><L><S><Q><D><D><I><K><G><I><Q><K><L><Y><G><K><R><S><N><S><R><K><K> | Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.<BOP> | P09237 |
Q9Y6W5 | WASF2_HUMAN | Wiskott-Aldrich syndrome protein family member 2 | Homo | <M><P><L><V><T><R><N><I><E><P><R><H><L><C><R><Q><T><L><P><S><V><R><S><E><L><E><C><V><T><N><I><T><L><A><N><V><I><R><Q><L><G><S><L><S><K><Y><A><E><D><I><F><G><E><L><F><T><Q><A><N><T><F><A><S><R><V><S><S><L><A><E><R><V><D><R><L><Q><V><K><V><T><Q><L><D><P><K><E><E><E><V><S><L><Q><G><I><N><T><R><K><A><F><R><S><S><T><I><Q><D><Q><K><L><F><D><R><N><S><L><P><V><P><V><L><E><T><Y><N><T><C><D><T><P><P><P><L><N><N><L><T><P><Y><R><D><D><G><K><E><A><L><K><F><Y><T><D><P><S><Y><F><F><D><L><W><K><E><K><M><L><Q><D><T><K><D><I><M><K><E><K><R><K><H><R><K><E><K><K><D><N><P><N><R><G><N><V><N><P><R><K><I><K><T><R><K><E><E><W><E><K><M><K><M><G><Q><E><F><V><E><S><K><E><K><L><G><T><S><G><Y><P><P><T><L><V><Y><Q><N><G><S><I><G><C><V><E><N><V><D><A><S><S><Y><P><P><P><P><Q><S><D><S><A><S><S><P><S><P><S><F><S><E><D><N><L><P><P><P><P><A><E><F><S><Y><P><V><D><N><Q><R><G><S><G><L><A><G><P><K><R><S><S><V><V><S><P><S><H><P><P><P><A><P><P><L><G><S><P><P><G><P><K><P><G><F><A><P><P><P><A><P><P><P><P><P><P><P><M><I><G><I><P><P><P><P><P><P><V><G><F><G><S><P><G><T><P><P><P><P><S><P><P><S><F><P><P><H><P><D><F><A><A><P><P><P><P><P><P><P><P><A><A><D><Y><P><T><L><P><P><P><P><L><S><Q><P><T><G><G><A><P><P><P><P><P><P><P><P><P><P><G><P><P><P><P><P><F><T><G><A><D><G><Q><P><A><I><P><P><P><L><S><D><T><T><K><P><K><S><S><L><P><A><V><S><D><A><R><S><D><L><L><S><A><I><R><Q><G><F><Q><L><R><R><V><E><E><Q><R><E><Q><E><K><R><D><V><V><G><N><D><V><A><T><I><L><S><R><R><I><A><V><E><Y><S><D><S><E><D><D><S><S><E><F><D><E><D><D><W><S><D> | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.<BOP> | Q9Y6W5 |
O95834 | EMAL2_HUMAN | Echinoderm microtubule-associated protein-like 2 | Homo | <M><S><S><F><G><A><G><K><T><K><E><V><I><F><S><V><E><D><G><S><V><K><M><F><L><R><G><R><P><V><P><M><M><I><P><D><E><L><A><P><T><Y><S><L><D><T><R><S><E><L><P><S><C><R><L><K><L><E><W><V><Y><G><Y><R><G><R><D><C><R><A><N><L><Y><L><L><P><T><G><E><I><V><Y><F><V><A><S><V><A><V><L><Y><S><V><E><E><Q><R><Q><R><H><Y><L><G><H><N><D><D><I><K><C><L><A><I><H><P><D><M><V><T><I><A><T><G><Q><V><A><G><T><T><K><E><G><K><P><L><P><P><H><V><R><I><W><D><S><V><S><L><S><T><L><H><V><L><G><L><G><V><F><D><R><A><V><C><C><V><G><F><S><K><S><N><G><G><N><L><L><C><A><V><D><E><S><N><D><H><M><L><S><V><W><D><W><A><K><E><T><K><V><V><D><V><K><C><S><N><E><A><V><L><V><A><T><F><H><P><T><D><P><T><V><L><I><T><C><G><K><S><H><I><Y><F><W><T><L><E><G><G><S><L><S><K><R><Q><G><L><F><E><K><H><E><K><P><K><Y><V><L><C><V><T><F><L><E><G><G><D><V><V><T><G><D><S><G><G><N><L><Y><V><W><G><K><G><G><N><R><I><T><Q><A><V><L><G><A><H><D><G><G><V><F><G><L><C><A><L><R><D><G><T><L><V><S><G><G><G><R><D><R><R><V><V><L><W><G><S><D><Y><S><K><L><Q><E><V><E><V><P><E><D><F><G><P><V><R><T><V><A><E><G><H><G><D><T><L><Y><V><G><T><T><R><N><S><I><L><Q><G><S><V><H><T><G><F><S><L><L><V><Q><G><H><V><E><E><L><W><G><L><A><T><H><P><S><R><A><Q><F><V><T><C><G><Q><D><K><L><V><H><L><W><S><S><D><S><H><Q><P><L><W><S><R><I><I><E><D><P><A><R><S><A><G><F><H><P><S><G><S><V><L><A><V><G><T><V><T><G><R><W><L><L><L><D><T><E><T><H><D><L><V><A><I><H><T><D><G><N><E><Q><I><S><V><V><S><F><S><P><D><G><A><Y><L><A><V><G><S><H><D><N><L><V><Y><V><Y><T><V><D><Q><G><G><R><K><V><S><R><L><G><K><C><S><G><H><S><S><F><I><T><H><L><D><W><A><Q><D><S><S><C><F><V><T><N><S><G><D><Y><E><I><L><Y><W><D><P><A><T><C><K><Q><I><T><S><A><D><A><V><R><N><M><E><W><A><T><A><T><C><V><L><G><F><G><V><F><G><I><W><S><E><G><A><D><G><T><D><I><N><A><V><A><R><S><H><D><G><K><L><L><A><S><A><D><D><F><G><K><V><H><L><F><S><Y><P><C><C><Q><P><R><A><L><S><H><K><Y><G><G><H><S><S><H><V><T><N><V><A><F><L><W><D><D><S><M><A><L><T><T><G><G><K><D><T><S><V><L><Q><W><R><V><V> | Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.<BOP> | O95834 |
Q9UH90 | FBX40_HUMAN | Muscle disease-related protein | Homo | <M><G><K><A><R><R><S><P><P><G><H><H><R><H><C><E><G><C><F><N><R><H><C><H><I><P><V><E><P><N><T><S><C><L><V><I><S><C><H><L><L><C><G><A><T><F><H><M><C><K><E><A><E><H><Q><L><L><C><P><L><E><Q><V><P><C><L><N><S><E><Y><G><C><P><L><S><M><S><R><H><K><L><A><K><H><L><Q><V><C><P><A><S><V><V><C><C><S><M><E><W><N><R><W><P><N><V><D><S><E><T><T><L><H><E><N><I><M><K><E><T><P><S><E><E><C><L><D><T><A><L><A><L><Q><D><Q><K><V><L><F><R><S><L><K><M><V><E><L><F><P><E><T><R><E><A><T><E><E><E><P><T><M><N><G><E><T><S><V><E><E><M><G><G><A><V><G><G><V><D><I><G><L><V><P><H><G><L><S><A><T><N><G><E><M><A><E><L><S><Q><E><E><R><E><V><L><A><K><T><K><E><G><M><D><L><V><K><F><G><Q><W><E><N><I><F><S><K><E><H><A><A><S><A><L><T><N><S><S><A><S><C><E><S><K><N><K><N><D><S><E><K><E><Q><I><S><S><G><H><N><M><V><E><G><E><G><A><P><K><K><K><E><P><Q><E><N><Q><K><Q><Q><D><V><R><T><A><M><E><T><T><G><L><A><P><W><Q><D><G><V><L><E><R><L><K><T><A><V><D><A><K><D><Y><N><M><Y><L><V><H><N><G><R><M><L><I><H><F><G><Q><M><P><A><C><T><P><K><E><R><D><F><V><Y><G><K><L><E><A><Q><E><V><K><T><V><Y><T><F><K><V><P><V><S><Y><C><G><K><R><A><R><L><G><D><A><M><L><S><C><K><P><S><E><H><K><A><V><D><T><S><D><L><G><I><T><V><E><D><L><P><K><S><D><L><I><K><T><T><L><Q><C><A><L><E><R><E><L><K><G><H><V><I><S><E><S><R><S><I><D><G><L><F><M><D><F><A><T><Q><T><Y><N><F><E><P><E><Q><F><S><S><G><T><V><L><A><D><L><T><A><A><T><P><G><G><L><H><V><E><L><H><S><E><C><V><T><R><R><H><N><K><S><S><S><A><F><T><F><T><C><N><K><F><F><R><R><D><E><F><P><L><H><F><K><N><V><H><T><D><I><Q><S><C><L><N><G><W><F><Q><H><R><C><P><L><A><Y><L><G><C><T><F><V><Q><N><H><F><R><P><P><G><Q><K><A><K><V><I><Y><S><Q><E><L><K><T><F><A><I><K><P><E><V><A><P><E><L><S><E><G><R><K><N><N><H><L><L><G><H><G><G><K><S><Q><N><S><L><T><S><L><P><L><E><I><L><K><Y><I><A><G><F><L><D><S><V><S><L><A><Q><L><S><Q><V><S><V><L><M><R><N><I><C><A><T><L><L><Q><E><R><G><M><V><L><L><Q><W><K><K><K><R><Y><S><H><G><G><T><S><W><R><V><H><R><E><I><W><Q><F><S><S><L><F><S><K><I><K><S><W><E><F><N><E><V><T><S><M><S><E><H><L><K><S><C><P><F><N><I><V><E><H><K><T><D><P><I><L><L><T><S><M><C><Q><P><R><E><Q><A><R><E><S><L><V><S><T><F><R><I><R><P><R><G><R><Y><V><S> | Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.<BOP> | Q9UH90 |
Q14916 | NPT1_HUMAN | Solute carrier family 17 member 1 | Homo | <M><Q><M><D><N><R><L><P><P><K><K><V><P><G><F><C><S><F><R><Y><G><L><S><F><L><V><H><C><C><N><V><I><I><T><A><Q><R><A><C><L><N><L><T><M><V><V><M><V><N><S><T><D><P><H><G><L><P><N><T><S><T><K><K><L><L><D><N><I><K><N><P><M><Y><N><W><S><P><D><I><Q><G><I><I><L><S><S><T><S><Y><G><V><I><I><I><Q><V><P><V><G><Y><F><S><G><I><Y><S><T><K><K><M><I><G><F><A><L><C><L><S><S><V><L><S><L><L><I><P><P><A><A><G><I><G><V><A><W><V><V><V><C><R><A><V><Q><G><A><A><Q><G><I><V><A><T><A><Q><F><E><I><Y><V><K><W><A><P><P><L><E><R><G><R><L><T><S><M><S><T><S><G><F><L><L><G><P><F><I><V><L><L><V><T><G><V><I><C><E><S><L><G><W><P><M><V><F><Y><I><F><G><A><C><G><C><A><V><C><L><L><W><F><V><L><F><Y><D><D><P><K><D><H><P><C><I><S><I><S><E><K><E><Y><I><T><S><S><L><V><Q><Q><V><S><S><S><R><Q><S><L><P><I><K><A><I><L><K><S><L><P><V><W><A><I><S><T><G><S><F><T><F><F><W><S><H><N><I><M><T><L><Y><T><P><M><F><I><N><S><M><L><H><V><N><I><K><E><N><G><F><L><S><S><L><P><Y><L><F><A><W><I><C><G><N><L><A><G><Q><L><S><D><F><F><L><T><R><N><I><L><S><V><I><A><V><R><K><L><F><T><A><A><G><F><L><L><P><A><I><F><G><V><C><L><P><Y><L><S><S><T><F><Y><S><I><V><I><F><L><I><L><A><G><A><T><G><S><F><C><L><G><G><V><F><I><N><G><L><D><I><A><P><R><Y><F><G><F><I><K><A><C><S><T><L><T><G><M><I><G><G><L><I><A><S><T><L><T><G><L><I><L><K><Q><D><P><E><S><A><W><F><K><T><F><I><L><M><A><A><I><N><V><T><G><L><I><F><Y><L><I><V><A><T><A><E><I><Q><D><W><A><K><E><K><Q><H><T><R><L> | Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney .<BOP> | Q14916 |
Q9NXI6 | RN186_HUMAN | RING finger protein 186 | Homo | <M><A><C><T><K><T><L><Q><Q><S><Q><P><I><S><A><G><A><T><T><T><T><T><A><V><A><P><A><G><G><H><S><G><S><T><E><C><D><L><E><C><L><V><C><R><E><P><Y><S><C><P><R><L><P><K><L><L><A><C><Q><H><A><F><C><A><I><C><L><K><L><L><L><C><V><Q><D><N><T><W><S><I><T><C><P><L><C><R><K><V><T><A><V><P><G><G><L><I><C><S><L><R><D><H><E><A><V><V><G><Q><L><A><Q><P><C><T><E><V><S><L><C><P><Q><G><L><V><D><P><A><D><L><A><A><G><H><P><S><L><V><G><E><D><G><Q><D><E><V><S><A><N><H><V><A><A><R><R><L><A><A><H><L><L><L><L><A><L><L><I><I><L><I><G><P><F><I><Y><P><G><V><L><R><W><V><L><T><F><I><I><A><L><A><L><L><M><S><T><L><F><C><C><L><P><S><T><R><G><S><C><W><P><S><S><R><T><L><F><C><R><E><Q><K><H><S><H><I><S><S><I><A> | E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress . Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis . Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR . Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction . Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity .<BOP> | Q9NXI6 |
Q8TCT6 | SPPL3_HUMAN | Presenilin-like protein 4 | Homo | <M><A><E><Q><T><Y><S><W><A><Y><S><L><V><D><S><S><Q><V><S><T><F><L><I><S><I><L><L><I><V><Y><G><S><F><R><S><L><N><M><D><F><E><N><Q><D><K><E><K><D><S><N><S><S><S><G><S><F><N><G><N><S><T><N><N><S><I><Q><T><I><D><S><T><Q><A><L><F><L><P><I><G><A><S><V><S><L><L><V><M><F><F><F><F><D><S><V><Q><V><V><F><T><I><C><T><A><V><L><A><T><I><A><F><A><F><L><L><L><P><M><C><Q><Y><L><T><R><P><C><S><P><Q><N><K><I><S><F><G><C><C><G><R><F><T><A><A><E><L><L><S><F><S><L><S><V><M><L><V><L><I><W><V><L><T><G><H><W><L><L><M><D><A><L><A><M><G><L><C><V><A><M><I><A><F><V><R><L><P><S><L><K><V><S><C><L><L><L><S><G><L><L><I><Y><D><V><F><W><V><F><F><S><A><Y><I><F><N><S><N><V><M><V><K><V><A><T><Q><P><A><D><N><P><L><D><V><L><S><R><K><L><H><L><G><P><N><V><G><R><D><V><P><R><L><S><L><P><G><K><L><V><F><P><S><S><T><G><S><H><F><S><M><L><G><I><G><D><I><V><M><P><G><L><L><L><C><F><V><L><R><Y><D><N><Y><K><K><Q><A><S><G><D><S><C><G><A><P><G><P><A><N><I><S><G><R><M><Q><K><V><S><Y><F><H><C><T><L><I><G><Y><F><V><G><L><L><T><A><T><V><A><S><R><I><H><R><A><A><Q><P><A><L><L><Y><L><V><P><F><T><L><L><P><L><L><T><M><A><Y><L><K><G><D><L><R><R><M><W><S><E><P><F><H><S><K><S><S><S><S><R><F><L><E><V> | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries . Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 . Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis . May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 . Plays a role in the regulation of cellular glycosylation processes . Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 | Q8TCT6 |
Q9UM11 | FZR1_HUMAN | Cdh1/Hct1 homolog | Homo | <M><D><Q><D><Y><E><R><R><L><L><R><Q><I><V><I><Q><N><E><N><T><M><P><R><V><T><E><M><R><R><T><L><T><P><A><S><S><P><V><S><S><P><S><K><H><G><D><R><F><I><P><S><R><A><G><A><N><W><S><V><N><F><H><R><I><N><E><N><E><K><S><P><S><Q><N><R><K><A><K><D><A><T><S><D><N><G><K><D><G><L><A><Y><S><A><L><L><K><N><E><L><L><G><A><G><I><E><K><V><Q><D><P><Q><T><E><D><R><R><L><Q><P><S><T><P><E><K><K><G><L><F><T><Y><S><L><S><T><K><R><S><S><P><D><D><G><N><D><V><S><P><Y><S><L><S><P><V><S><N><K><S><Q><K><L><L><R><S><P><R><K><P><T><R><K><I><S><K><I><P><F><K><V><L><D><A><P><E><L><Q><D><D><F><Y><L><N><L><V><D><W><S><S><L><N><V><L><S><V><G><L><G><T><C><V><Y><L><W><S><A><C><T><S><Q><V><T><R><L><C><D><L><S><V><E><G><D><S><V><T><S><V><G><W><S><E><R><G><N><L><V><A><V><G><T><H><K><G><F><V><Q><I><W><D><A><A><A><G><K><K><L><S><M><L><E><G><H><T><A><R><V><G><A><L><A><W><N><A><E><Q><L><S><S><G><S><R><D><R><M><I><L><Q><R><D><I><R><T><P><P><L><Q><S><E><R><R><L><Q><G><H><R><Q><E><V><C><G><L><K><W><S><T><D><H><Q><L><L><A><S><G><G><N><D><N><K><L><L><V><W><N><H><S><S><L><S><P><V><Q><Q><Y><T><E><H><L><A><A><V><K><A><I><A><W><S><P><H><Q><H><G><L><L><A><S><G><G><G><T><A><D><R><C><I><R><F><W><N><T><L><T><G><Q><P><L><Q><C><I><D><T><G><S><Q><V><C><N><L><A><W><S><K><H><A><N><E><L><V><S><T><H><G><Y><S><Q><N><Q><I><L><V><W><K><Y><P><S><L><T><Q><V><A><K><L><T><G><H><S><Y><R><V><L><Y><L><A><M><S><P><D><G><E><A><I><V><T><G><A><G><D><E><T><L><R><F><W><N><V><F><S><K><T><R><S><T><K><V><K><W><E><S><V><S><V><L><N><L><F><T><R><I><R> | Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) .<BOP> | Q9UM11 |
Q712K3 | UB2R2_HUMAN | Ubiquitin-protein ligase R2 | Homo | <M><A><Q><Q><Q><M><T><S><S><Q><K><A><L><M><L><E><L><K><S><L><Q><E><E><P><V><E><G><F><R><I><T><L><V><D><E><S><D><L><Y><N><W><E><V><A><I><F><G><P><P><N><T><L><Y><E><G><G><Y><F><K><A><H><I><K><F><P><I><D><Y><P><Y><S><P><P><T><F><R><F><L><T><K><M><W><H><P><N><I><Y><E><N><G><D><V><C><I><S><I><L><H><P><P><V><D><D><P><Q><S><G><E><L><P><S><E><R><W><N><P><T><Q><N><V><R><T><I><L><L><S><V><I><S><L><L><N><E><P><N><T><F><S><P><A><N><V><D><A><S><V><M><F><R><K><W><R><D><S><K><G><K><D><K><E><Y><A><E><I><I><R><K><Q><V><S><A><T><K><A><E><A><E><K><D><G><V><K><V><P><T><T><L><A><E><Y><C><I><K><T><K><V><P><S><N><D><N><S><S><D><L><L><Y><D><D><L><Y><D><D><D><I><D><D><E><D><E><E><E><E><D><A><D><C><Y><D><D><D><D><S><G><N><E><E><S> | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.<BOP> | Q712K3 |
P49915 | GUAA_HUMAN | Glutamine amidotransferase | Homo | <M><A><L><C><N><G><D><S><K><L><E><N><A><G><G><D><L><K><D><G><H><H><H><Y><E><G><A><V><V><I><L><D><A><G><A><Q><Y><G><K><V><I><D><R><R><V><R><E><L><F><V><Q><S><E><I><F><P><L><E><T><P><A><F><A><I><K><E><Q><G><F><R><A><I><I><I><S><G><G><P><N><S><V><Y><A><E><D><A><P><W><F><D><P><A><I><F><T><I><G><K><P><V><L><G><I><C><Y><G><M><Q><M><M><N><K><V><F><G><G><T><V><H><K><K><S><V><R><E><D><G><V><F><N><I><S><V><D><N><T><C><S><L><F><R><G><L><Q><K><E><E><V><V><L><L><T><H><G><D><S><V><D><K><V><A><D><G><F><K><V><V><A><R><S><G><N><I><V><A><G><I><A><N><E><S><K><K><L><Y><G><A><Q><F><H><P><E><V><G><L><T><E><N><G><K><V><I><L><K><N><F><L><Y><D><I><A><G><C><S><G><T><F><T><V><Q><N><R><E><L><E><C><I><R><E><I><K><E><R><V><G><T><S><K><V><L><V><L><L><S><G><G><V><D><S><T><V><C><T><A><L><L><N><R><A><L><N><Q><E><Q><V><I><A><V><H><I><D><N><G><F><M><R><K><R><E><S><Q><S><V><E><E><A><L><K><K><L><G><I><Q><V><K><V><I><N><A><A><H><S><F><Y><N><G><T><T><T><L><P><I><S><D><E><D><R><T><P><R><K><R><I><S><K><T><L><N><M><T><T><S><P><E><E><K><R><K><I><I><G><D><T><F><V><K><I><A><N><E><V><I><G><E><M><N><L><K><P><E><E><V><F><L><A><Q><G><T><L><R><P><D><L><I><E><S><A><S><L><V><A><S><G><K><A><E><L><I><K><T><H><H><N><D><T><E><L><I><R><K><L><R><E><E><G><K><V><I><E><P><L><K><D><F><H><K><D><E><V><R><I><L><G><R><E><L><G><L><P><E><E><L><V><S><R><H><P><F><P><G><P><G><L><A><I><R><V><I><C><A><E><E><P><Y><I><C><K><D><F><P><E><T><N><N><I><L><K><I><V><A><D><F><S><A><S><V><K><K><P><H><T><L><L><Q><R><V><K><A><C><T><T><E><E><D><Q><E><K><L><M><Q><I><T><S><L><H><S><L><N><A><F><L><L><P><I><K><T><V><G><V><Q><G><D><C><R><S><Y><S><Y><V><C><G><I><S><S><K><D><E><P><D><W><E><S><L><I><F><L><A><R><L><I><P><R><M><C><H><N><V><N><R><V><V><Y><I><F><G><P><P><V><K><E><P><P><T><D><V><T><P><T><F><L><T><T><G><V><L><S><T><L><R><Q><A><D><F><E><A><H><N><I><L><R><E><S><G><Y><A><G><K><I><S><Q><M><P><V><I><L><T><P><L><H><F><D><R><D><P><L><Q><K><Q><P><S><C><Q><R><S><V><V><I><R><T><F><I><T><S><D><F><M><T><G><I><P><A><T><P><G><N><E><I><P><V><E><V><V><L><K><M><V><T><E><I><K><K><I><P><G><I><S><R><I><M><Y><D><L><T><S><K><P><P><G><T><T><E><W><E> | Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.<BOP> | P49915 |
P18827 | SDC1_HUMAN | Syndecan-1 | Homo | <M><R><R><A><A><L><W><L><W><L><C><A><L><A><L><S><L><Q><P><A><L><P><Q><I><V><A><T><N><L><P><P><E><D><Q><D><G><S><G><D><D><S><D><N><F><S><G><S><G><A><G><A><L><Q><D><I><T><L><S><Q><Q><T><P><S><T><W><K><D><T><Q><L><L><T><A><I><P><T><S><P><E><P><T><G><L><E><A><T><A><A><S><T><S><T><L><P><A><G><E><G><P><K><E><G><E><A><V><V><L><P><E><V><E><P><G><L><T><A><R><E><Q><E><A><T><P><R><P><R><E><T><T><Q><L><P><T><T><H><L><A><S><T><T><T><A><T><T><A><Q><E><P><A><T><S><H><P><H><R><D><M><Q><P><G><H><H><E><T><S><T><P><A><G><P><S><Q><A><D><L><H><T><P><H><T><E><D><G><G><P><S><A><T><E><R><A><A><E><D><G><A><S><S><Q><L><P><A><A><E><G><S><G><E><Q><D><F><T><F><E><T><S><G><E><N><T><A><V><V><A><V><E><P><D><R><R><N><Q><S><P><V><D><Q><G><A><T><G><A><S><Q><G><L><L><D><R><K><E><V><L><G><G><V><I><A><G><G><L><V><G><L><I><F><A><V><C><L><V><G><F><M><L><Y><R><M><K><K><K><D><E><G><S><Y><S><L><E><E><P><K><Q><A><N><G><G><A><Y><Q><K><P><T><K><Q><E><E><F><Y><A> | Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP .<BOP> | P18827 |
P49450 | CENPA_HUMAN | Centromere protein A | Homo | <M><G><P><R><R><R><S><R><K><P><E><A><P><R><R><R><S><P><S><P><T><P><T><P><G><P><S><R><R><G><P><S><L><G><A><S><S><H><Q><H><S><R><R><R><Q><G><W><L><K><E><I><R><K><L><Q><K><S><T><H><L><L><I><R><K><L><P><F><S><R><L><A><R><E><I><C><V><K><F><T><R><G><V><D><F><N><W><Q><A><Q><A><L><L><A><L><Q><E><A><A><E><A><F><L><V><H><L><F><E><D><A><Y><L><L><T><L><H><A><G><R><V><T><L><F><P><K><D><V><Q><L><A><R><R><I><R><G><L><E><E><G><L><G> | Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes . Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore . The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 . May serve as an epigenetic mark that propagates centromere identity through replication and cell division . Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis .<BOP> | P49450 |
O43559 | FRS3_HUMAN | Suc1-associated neurotrophic factor target 2 | Homo | <M><G><S><C><C><S><C><L><N><R><D><S><V><P><D><N><H><P><T><K><F><K><V><T><N><V><D><D><E><G><V><E><L><G><S><G><V><M><E><L><T><Q><S><E><L><V><L><H><L><H><R><R><E><A><V><R><W><P><Y><L><C><L><R><R><Y><G><Y><D><S><N><L><F><S><F><E><S><G><R><R><C><Q><T><G><Q><G><I><F><A><F><K><C><S><R><A><E><E><I><F><N><L><L><Q><D><L><M><Q><C><N><S><I><N><V><M><E><E><P><V><I><I><T><R><N><S><H><P><A><E><L><D><L><P><R><A><P><Q><P><P><N><A><L><G><Y><T><V><S><S><F><S><N><G><C><P><G><E><G><P><R><F><S><A><P><R><R><L><S><T><S><S><L><R><H><P><S><L><G><E><E><S><T><H><A><L><I><A><P><D><E><Q><S><H><T><Y><V><N><T><P><A><S><E><D><D><H><R><R><G><R><H><C><L><Q><P><L><P><E><G><Q><A><P><F><L><P><Q><A><R><G><P><D><Q><R><D><P><Q><V><F><L><Q><P><G><Q><V><K><F><V><L><G><P><T><P><A><R><R><H><M><V><K><C><Q><G><L><C><P><S><L><H><D><P><P><H><H><N><N><N><N><E><A><P><S><E><C><P><A><Q><P><K><C><T><Y><E><N><V><T><G><G><L><W><R><G><A><G><W><R><L><S><P><E><E><P><G><W><N><G><L><A><H><R><R><A><A><L><L><H><Y><E><N><L><P><P><L><P><P><V><W><E><S><Q><A><Q><Q><L><G><G><E><A><G><D><D><G><D><S><R><D><G><L><T><P><S><S><N><G><F><P><D><G><E><E><D><E><T><P><L><Q><K><P><T><S><T><R><A><A><I><R><S><H><G><S><F><P><V><P><L><T><R><R><R><G><S><P><R><V><F><N><F><D><F><R><R><P><G><P><E><P><P><R><Q><L><N><Y><I><Q><V><E><L><K><G><W><G><G><D><R><P><K><G><P><Q><N><P><S><S><P><Q><A><P><M><P><T><T><H><P><A><R><S><S><D><S><Y><A><V><I><D><L><K><K><T><V><A><M><S><N><L><Q><R><A><L><P><R><D><D><G><T><A><R><K><T><R><H><N><S><T><D><L><P><L> | Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.<BOP> | O43559 |
P0DOX3 | IGD_HUMAN | Immunoglobulin delta heavy chain WAH | Homo | <R><L><Q><L><Q><E><S><G><P><G><L><V><K><P><S><E><T><L><S><L><T><C><I><V><S><G><G><P><I><R><R><T><G><Y><Y><W><G><W><I><R><Q><P><P><G><K><G><L><E><W><I><G><G><V><Y><Y><T><G><S><I><Y><Y><N><P><S><L><R><G><R><V><T><I><S><V><D><T><S><R><N><Q><F><S><L><N><L><R><S><M><S><A><A><D><T><A><M><Y><Y><C><A><R><G><N><P><P><P><Y><Y><D><I><G><T><G><S><D><D><G><I><D><V><W><G><Q><G><T><T><V><H><V><S><S><A><P><T><K><A><P><D><V><F><P><I><I><S><G><C><R><H><P><K><D><N><S><P><V><V><L><A><C><L><I><T><G><Y><H><P><T><S><V><T><V><T><W><Y><M><G><T><Q><S><Q><P><Q><R><T><F><P><E><I><Q><R><R><D><S><Y><Y><M><T><S><S><Q><L><S><T><P><L><Q><Q><W><R><Q><G><E><Y><K><C><V><V><Q><H><T><A><S><K><S><K><K><E><I><F><R><W><P><E><S><P><K><A><Q><A><S><S><V><P><T><A><Q><P><Q><A><E><G><S><L><A><K><A><T><T><A><P><A><T><T><R><N><T><G><R><G><G><E><E><K><K><K><E><K><E><K><E><E><Q><E><E><R><E><T><K><T><P><E><C><P><S><H><T><Q><P><L><G><V><Y><L><L><T><P><A><V><Q><D><L><W><L><R><D><K><A><T><F><T><C><F><V><V><G><S><D><L><K><D><A><H><L><T><W><E><V><A><G><K><V><P><T><G><G><V><E><E><G><L><L><E><R><H><S><N><G><S><Q><S><Q><H><S><R><L><T><L><P><R><S><L><W><N><A><G><T><S><V><T><C><T><L><N><H><P><S><L><P><P><Q><R><L><M><A><L><R><E><P><A><A><Q><A><P><V><K><L><S><L><N><L><L><A><S><S><D><P><P><E><A><A><S><W><L><L><C><E><V><S><G><F><S><P><P><N><I><L><L><M><W><L><E><D><Q><R><E><V><N><T><S><G><F><A><P><A><R><P><P><P><Q><P><G><S><T><T><F><W><A><W><S><V><L><R><V><P><A><P><P><S><P><Q><P><A><T><Y><T><C><V><V><S><H><E><D><S><R><T><L><L><N><A><S><R><S><L><E><V><S><Y><V><T><D><H><G><P><M> | Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen . IgD is the major antigen receptor isotype on the surface of most peripheral B cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. | P0DOX3 |
A6NJZ3 | O6C65_HUMAN | Olfactory receptor 6C65 | Homo | <M><P><N><M><T><S><I><R><E><F><I><L><L><G><F><T><D><N><P><E><L><Q><V><V><I><F><F><F><M><L><I><T><Y><L><L><S><V><S><G><N><M><I><I><I><M><L><T><L><S><N><I><H><L><K><T><P><M><Y><F><F><L><R><N><F><S><F><L><E><I><S><F><T><T><V><F><I><P><R><F><L><I><N><I><A><T><G><D><T><T><I><S><Y><N><A><S><M><A><Q><V><F><F><L><I><L><L><G><S><T><E><F><F><L><L><A><V><M><S><Y><D><R><Y><V><A><I><C><K><P><L><H><Y><T><T><I><M><S><N><K><V><C><N><W><L><V><I><S><S><W><L><A><G><F><L><I><I><F><P><P><V><I><M><G><L><Q><L><D><F><C><D><S><S><T><I><D><H><F><I><C><D><S><S><P><M><L><L><I><A><C><T><D><T><Q><F><L><E><L><M><A><F><L><L><A><V><F><T><L><M><V><T><L><A><L><V><V><L><S><Y><T><L><I><L><K><T><I><L><K><I><P><S><A><Q><Q><R><K><K><A><F><S><T><C><S><S><H><M><I><V><V><S><V><S><Y><G><S><C><I><F><M><C><V><K><T><S><A><K><E><G><M><A><L><S><K><G><V><A><V><L><N><T><S><V><A><P><M><L><N><P><F><I><Y><T><L><R><N><Q><Q><V><K><Q><A><L><R><E><F><T><K><K><I><L><S><L><N><K><Q> | Odorant receptor.<BOP> | A6NJZ3 |
P22304 | IDS_HUMAN | Iduronate 2-sulfatase 14 kDa chain | Homo | <M><P><P><P><R><T><G><R><G><L><L><W><L><G><L><V><L><S><S><V><C><V><A><L><G><S><E><T><Q><A><N><S><T><T><D><A><L><N><V><L><L><I><I><V><D><D><L><R><P><S><L><G><C><Y><G><D><K><L><V><R><S><P><N><I><D><Q><L><A><S><H><S><L><L><F><Q><N><A><F><A><Q><Q><A><V><C><A><P><S><R><V><S><F><L><T><G><R><R><P><D><T><T><R><L><Y><D><F><N><S><Y><W><R><V><H><A><G><N><F><S><T><I><P><Q><Y><F><K><E><N><G><Y><V><T><M><S><V><G><K><V><F><H><P><G><I><S><S><N><H><T><D><D><S><P><Y><S><W><S><F><P><P><Y><H><P><S><S><E><K><Y><E><N><T><K><T><C><R><G><P><D><G><E><L><H><A><N><L><L><C><P><V><D><V><L><D><V><P><E><G><T><L><P><D><K><Q><S><T><E><Q><A><I><Q><L><L><E><K><M><K><T><S><A><S><P><F><F><L><A><V><G><Y><H><K><P><H><I><P><F><R><Y><P><K><E><F><Q><K><L><Y><P><L><E><N><I><T><L><A><P><D><P><E><V><P><D><G><L><P><P><V><A><Y><N><P><W><M><D><I><R><Q><R><E><D><V><Q><A><L><N><I><S><V><P><Y><G><P><I><P><V><D><F><Q><R><K><I><R><Q><S><Y><F><A><S><V><S><Y><L><D><T><Q><V><G><R><L><L><S><A><L><D><D><L><Q><L><A><N><S><T><I><I><A><F><T><S><D><H><G><W><A><L><G><E><H><G><E><W><A><K><Y><S><N><F><D><V><A><T><H><V><P><L><I><F><Y><V><P><G><R><T><A><S><L><P><E><A><G><E><K><L><F><P><Y><L><D><P><F><D><S><A><S><Q><L><M><E><P><G><R><Q><S><M><D><L><V><E><L><V><S><L><F><P><T><L><A><G><L><A><G><L><Q><V><P><P><R><C><P><V><P><S><F><H><V><E><L><C><R><E><G><K><N><L><L><K><H><F><R><F><R><D><L><E><E><D><P><Y><L><P><G><N><P><R><E><L><I><A><Y><S><Q><Y><P><R><P><S><D><I><P><Q><W><N><S><D><K><P><S><L><K><D><I><K><I><M><G><Y><S><I><R><T><I><D><Y><R><Y><T><V><W><V><G><F><N><P><D><E><F><L><A><N><F><S><D><I><H><A><G><E><L><Y><F><V><D><S><D><P><L><Q><D><H><N><M><Y><N><D><S><Q><G><G><D><L><F><Q><L><L><M><P> | Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.<BOP> | P22304 |
Q8IXH7 | NELFD_HUMAN | TH1-like protein | Homo | <M><A><G><A><V><P><G><A><I><M><D><E><D><Y><Y><G><S><A><A><E><W><G><D><E><A><D><G><G><Q><Q><E><D><D><S><G><E><G><E><D><D><A><E><V><Q><Q><E><C><L><H><K><F><S><T><R><D><Y><I><M><E><P><S><I><F><N><T><L><K><R><Y><F><Q><A><G><G><S><P><E><N><V><I><Q><L><L><S><E><N><Y><T><A><V><A><Q><T><V><N><L><L><A><E><W><L><I><Q><T><G><V><E><P><V><Q><V><Q><E><T><V><E><N><H><L><K><S><L><L><I><K><H><F><D><P><R><K><A><D><S><I><F><T><E><E><G><E><T><P><A><W><L><E><Q><M><I><A><H><T><T><W><R><D><L><F><Y><K><L><A><E><A><H><P><D><C><L><M><L><N><F><T><V><K><L><I><S><D><A><G><Y><Q><G><E><I><T><S><V><S><T><A><C><Q><Q><L><E><V><F><S><R><V><L><R><T><S><L><A><T><I><L><D><G><G><E><E><N><L><E><K><N><L><P><E><F><A><K><M><V><C><H><G><E><H><T><Y><L><F><A><Q><A><M><M><S><V><L><A><Q><E><E><Q><G><G><S><A><V><R><R><I><A><Q><E><V><Q><R><F><A><Q><E><K><G><H><D><A><S><Q><I><T><L><A><L><G><T><A><A><S><Y><P><R><A><C><Q><A><L><G><A><M><L><S><K><G><A><L><N><P><A><D><I><T><V><L><F><K><M><F><T><S><M><D><P><P><P><V><E><L><I><R><V><P><A><F><L><D><L><F><M><Q><S><L><F><K><P><G><A><R><I><N><Q><D><H><K><H><K><Y><I><H><I><L><A><Y><A><A><S><V><V><E><T><W><K><K><N><K><R><V><S><I><N><K><D><E><L><K><S><T><S><K><A><V><E><T><V><H><N><L><C><C><N><E><N><K><G><A><S><E><L><V><A><E><L><S><T><L><Y><Q><C><I><R><F><P><V><V><A><M><G><V><L><K><W><V><D><W><T><V><S><E><P><R><Y><F><Q><L><Q><T><D><H><T><P><V><H><L><A><L><L><D><E><I><S><T><C><H><Q><L><L><H><P><Q><V><L><Q><L><L><V><K><L><F><E><T><E><H><S><Q><L><D><V><M><E><Q><L><E><L><K><K><T><L><L><D><R><M><V><H><L><L><S><R><G><Y><V><L><P><V><V><S><Y><I><R><K><C><L><E><K><L><D><T><D><I><S><L><I><R><Y><F><V><T><E><V><L><D><V><I><A><P><P><Y><T><S><D><F><V><Q><L><F><L><P><I><L><E><N><D><S><I><A><G><T><I><K><T><E><G><E><H><D><P><V><T><E><F><I><A><H><C><K><S><N><F><I><M><V><N> | (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.<BOP> | Q8IXH7 |
P24903 | CP2F1_HUMAN | CYPIIF1 | Homo | <M><D><S><I><S><T><A><I><L><L><L><L><L><A><L><V><C><L><L><L><T><L><S><S><R><D><K><G><K><L><P><P><G><P><R><P><L><S><I><L><G><N><L><L><L><L><C><S><Q><D><M><L><T><S><L><T><K><L><S><K><E><Y><G><S><M><Y><T><V><H><L><G><P><R><R><V><V><V><L><S><G><Y><Q><A><V><K><E><A><L><V><D><Q><G><E><E><F><S><G><R><G><D><Y><P><A><F><F><N><F><T><K><G><N><G><I><A><F><S><S><G><D><R><W><K><V><L><R><Q><F><S><I><Q><I><L><R><N><F><G><M><G><K><R><S><I><E><E><R><I><L><E><E><G><S><F><L><L><A><E><L><R><K><T><E><G><E><P><F><D><P><T><F><V><L><S><R><S><V><S><N><I><I><C><S><V><L><F><G><S><R><F><D><Y><D><D><E><R><L><L><T><I><I><R><L><I><N><D><N><F><Q><I><M><S><S><P><W><G><E><L><Y><D><I><F><P><S><L><L><D><W><V><P><G><P><H><Q><R><I><F><Q><N><F><K><C><L><R><D><L><I><A><H><S><V><H><D><H><Q><A><S><L><D><P><R><S><P><R><D><F><I><Q><C><F><L><T><K><M><A><E><E><K><E><D><P><L><S><H><F><H><M><D><T><L><L><M><T><T><H><N><L><L><F><G><G><T><K><T><V><S><T><T><L><H><H><A><F><L><A><L><M><K><Y><P><K><V><Q><A><R><V><Q><E><E><I><D><L><V><V><G><R><A><R><L><P><A><L><K><D><R><A><A><M><P><Y><T><D><A><V><I><H><E><V><Q><R><F><A><D><I><I><P><M><N><L><P><H><R><V><T><R><D><T><A><F><R><G><F><L><I><P><K><G><T><D><V><I><T><L><L><N><T><V><H><Y><D><P><S><Q><F><L><T><P><Q><E><F><N><P><E><H><F><L><D><A><N><Q><S><F><K><K><S><P><A><F><M><P><F><S><A><G><R><R><L><C><L><G><E><S><L><A><R><M><E><L><F><L><Y><L><T><A><I><L><Q><S><F><S><L><Q><P><L><G><A><P><E><D><I><D><L><T><P><L><S><S><G><L><G><N><L><P><R><P><F><Q><L><C><L><R><P><R> | May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.<BOP> | P24903 |
Q8N8J6 | ZN615_HUMAN | Zinc finger protein 615 | Homo | <M><M><Q><A><Q><E><S><L><T><L><E><D><V><A><V><D><F><T><W><E><E><W><Q><F><L><S><P><A><Q><K><D><L><Y><R><D><V><M><L><E><N><Y><S><N><L><V><A><V><G><Y><Q><A><S><K><P><D><A><L><S><K><L><E><R><G><E><E><T><C><T><T><E><D><E><I><Y><S><R><I><C><S><E><I><R><K><I><D><D><P><L><Q><H><H><L><Q><N><Q><S><I><Q><K><S><V><K><Q><C><H><E><Q><N><M><F><G><N><I><V><N><Q><N><K><G><H><F><L><L><K><Q><D><C><D><T><F><D><L><H><E><K><P><L><K><S><N><L><S><F><E><N><Q><K><R><S><S><G><L><K><N><S><A><E><F><N><R><D><G><K><S><L><F><H><A><N><H><K><Q><F><Y><T><E><M><K><F><P><A><I><A><K><P><I><N><K><S><Q><F><I><K><Q><Q><R><T><H><N><I><E><N><A><H><V><C><S><E><C><G><K><A><F><L><K><L><S><Q><F><I><D><H><Q><R><V><H><T><G><E><K><P><H><V><C><S><M><C><G><K><A><F><S><R><K><S><R><L><M><D><H><Q><R><T><H><T><E><L><K><H><Y><E><C><T><E><C><D><K><T><F><L><K><K><S><Q><L><N><I><H><Q><K><T><H><M><G><G><K><P><Y><T><C><S><Q><C><G><K><A><F><I><K><K><C><R><L><I><Y><H><Q><R><T><H><T><G><E><K><P><H><G><C><S><V><C><G><K><A><F><S><T><K><F><S><L><T><T><H><Q><K><T><H><T><G><E><K><P><Y><I><C><S><E><C><G><K><G><F><I><E><K><R><R><L><T><A><H><H><R><T><H><T><G><E><K><P><F><I><C><N><K><C><G><K><G><F><T><L><K><N><S><L><I><T><H><Q><Q><T><H><T><G><E><K><L><Y><T><C><S><E><C><G><K><G><F><S><M><K><H><C><L><M><V><H><Q><R><T><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><G><F><A><L><K><S><P><L><I><R><H><Q><R><T><H><T><G><E><K><P><Y><V><C><T><E><C><R><K><G><F><T><M><K><S><D><L><I><V><H><Q><R><T><H><T><A><E><K><P><Y><I><C><N><D><C><G><K><G><F><T><V><K><S><R><L><I><V><H><Q><R><T><H><T><G><E><K><P><Y><V><C><G><E><C><G><K><G><F><P><A><K><I><R><L><M><G><H><Q><R><T><H><T><G><E><K><P><Y><I><C><N><E><C><G><K><G><F><T><E><K><S><H><L><N><V><H><R><R><T><H><T><G><E><K><P><Y><V><C><S><E><C><G><K><G><L><T><G><K><S><M><L><I><A><H><Q><R><T><H><T><G><E><K><P><Y><I><C><N><E><C><G><K><G><F><T><M><K><S><T><L><S><I><H><Q><Q><T><H><T><G><E><K><P><Y><K><C><N><E><C><D><K><T><F><R><K><K><T><C><L><I><Q><H><Q><R><F><H><T><G><K><T><S><F><A><C><T><E><C><G><K><F><S><L><R><K><N><D><L><I><T><H><Q><R><I><H><T><G><E><K><P><Y><K><C><S><D><C><G><K><A><F><T><T><K><S><G><L><N><V><H><Q><R><K><H><T><G><E><R><P><Y><G><C><S><D><C><G><K><A><F><A><H><L><S><I><L><V><K><H><R><R><I><H><R> | May be involved in transcriptional regulation.<BOP> | Q8N8J6 |
O15466 | SIA8E_HUMAN | Sialyltransferase St8Sia V | Homo | <M><R><Y><A><D><P><S><A><N><R><D><L><L><G><S><R><T><L><L><F><I><F><I><C><A><F><A><L><V><T><L><L><Q><Q><I><L><Y><G><R><N><Y><I><K><R><Y><F><E><F><Y><E><G><P><F><E><Y><N><S><T><R><C><L><E><L><R><H><E><I><L><E><V><K><V><L><S><M><V><K><Q><S><E><L><F><D><R><W><K><S><L><Q><M><C><K><W><A><M><N><I><S><E><A><N><Q><F><K><S><T><L><S><R><C><C><N><A><P><A><F><L><F><T><T><Q><K><N><T><P><L><G><T><K><L><K><Y><E><V><D><T><S><G><I><Y><H><I><N><Q><E><I><F><R><M><F><P><K><D><M><P><Y><Y><R><S><Q><F><K><K><C><A><V><V><G><N><G><G><I><L><K><N><S><R><C><G><R><E><I><N><S><A><D><F><V><F><R><C><N><L><P><P><I><S><E><K><Y><T><M><D><V><G><V><K><T><D><V><V><T><V><N><P><S><I><I><T><E><R><F><H><K><L><E><K><W><R><R><P><F><Y><R><V><L><Q><V><Y><E><N><A><S><V><L><L><P><A><F><Y><N><T><R><N><T><D><V><S><I><R><V><K><Y><V><L><D><D><F><E><S><P><Q><A><V><Y><Y><F><H><P><Q><Y><L><V><N><V><S><R><Y><W><L><S><L><G><V><R><A><K><R><I><S><T><G><L><I><L><V><T><A><A><L><E><L><C><E><E><V><H><L><F><G><F><W><A><F><P><M><N><P><S><G><L><Y><I><T><H><H><Y><Y><D><N><V><K><P><R><P><G><F><H><A><M><P><S><E><I><F><N><F><L><H><L><H><S><R><G><I><L><R><V><H><T><G><T><C><S><C><C> | Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively.<BOP> | O15466 |
Q13190 | STX5_HUMAN | Syntaxin-5 | Homo | <M><I><P><R><K><R><Y><G><S><K><N><T><D><Q><G><V><Y><L><G><L><S><K><T><Q><V><L><S><P><A><T><A><G><S><S><S><S><D><I><A><P><L><P><P><P><V><T><L><V><P><P><P><P><D><T><M><S><C><R><D><R><T><Q><E><F><L><S><A><C><K><S><L><Q><T><R><Q><N><G><I><Q><T><N><K><P><A><L><R><A><V><R><Q><R><S><E><F><T><L><M><A><K><R><I><G><K><D><L><S><N><T><F><A><K><L><E><K><L><T><I><L><A><K><R><K><S><L><F><D><D><K><A><V><E><I><E><E><L><T><Y><I><I><K><Q><D><I><N><S><L><N><K><Q><I><A><Q><L><Q><D><F><V><R><A><K><G><S><Q><S><G><R><H><L><Q><T><H><S><N><T><I><V><V><S><L><Q><S><K><L><A><S><M><S><N><D><F><K><S><V><L><E><V><R><T><E><N><L><K><Q><Q><R><S><R><R><E><Q><F><S><R><A><P><V><S><A><L><P><L><A><P><N><H><L><G><G><G><A><V><V><L><G><A><E><S><H><A><S><K><D><V><A><I><D><M><M><D><S><R><T><S><Q><Q><L><Q><L><I><D><E><Q><D><S><Y><I><Q><S><R><A><D><T><M><Q><N><I><E><S><T><I><V><E><L><G><S><I><F><Q><Q><L><A><H><M><V><K><E><Q><E><E><T><I><Q><R><I><D><E><N><V><L><G><A><Q><L><D><V><E><A><A><H><S><E><I><L><K><Y><F><Q><S><V><T><S><N><R><W><L><M><V><K><I><F><L><I><L><I><V><F><F><I><I><F><V><V><F><L><A> | (Microbial infection) Required for the efficient production of infectious virion during human cytomegalovirus infection. Mechanistically, participates in the formation of the cytoplasmic viral assembly compartment where tegument acquisition and envelopment occur.<BOP> | Q13190 |
Q5BKT4 | AG10A_HUMAN | Asparagine-linked glycosylation protein 10 homolog A | Homo | <M><A><Q><L><E><G><Y><Y><F><S><A><A><L><S><C><T><F><L><V><S><C><L><L><F><S><A><F><S><R><A><L><R><E><P><Y><M><D><E><I><F><H><L><P><Q><A><Q><R><Y><C><E><G><H><F><S><L><S><Q><W><D><P><M><I><T><T><L><P><G><L><Y><L><V><S><I><G><V><I><K><P><A><I><W><I><F><G><W><S><E><H><V><V><C><S><I><G><M><L><R><F><V><N><L><L><F><S><V><G><N><F><Y><L><L><Y><L><L><F><C><K><V><Q><P><R><N><K><A><A><S><S><I><Q><R><V><L><S><T><L><T><L><A><V><F><P><T><L><Y><F><F><N><F><L><Y><Y><T><E><A><G><S><M><F><F><T><L><F><A><Y><L><M><C><L><Y><G><N><H><K><T><S><A><F><L><G><F><C><G><F><M><F><R><Q><T><N><I><I><W><A><V><F><C><A><G><N><V><I><A><Q><K><L><T><E><A><W><K><T><E><L><Q><K><K><E><D><R><L><P><P><I><K><G><P><F><A><E><F><R><K><I><L><Q><F><L><L><A><Y><S><M><S><F><K><N><L><S><M><L><L><L><L><T><W><P><Y><I><L><L><G><F><L><F><C><A><F><V><V><V><N><G><G><I><V><I><G><D><R><S><S><H><E><A><C><L><H><F><P><Q><L><F><Y><F><F><S><F><T><L><F><F><S><F><P><H><L><L><S><P><S><K><I><K><T><F><L><S><L><V><W><K><R><R><I><L><F><F><V><V><T><L><V><S><V><F><L><V><W><K><F><T><Y><A><H><K><Y><L><L><A><D><N><R><H><Y><T><F><Y><V><W><K><R><V><F><Q><R><Y><E><T><V><K><Y><L><L><V><P><A><Y><I><F><A><G><W><S><I><A><D><S><L><K><S><K><S><I><F><W><N><L><M><F><F><I><C><L><F><T><V><I><V><P><Q><K><L><L><E><F><R><Y><F><I><L><P><Y><V><I><Y><R><L><N><I><P><L><P><P><T><S><R><L><I><C><E><L><S><C><Y><A><V><V><N><F><I><T><F><F><I><F><L><N><K><T><F><Q><W><P><N><S><Q><D><I><Q><R><F><M><W> | Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.<BOP> | Q5BKT4 |
Q99954 | SMR3A_HUMAN | Proline-rich protein PBI | Homo | <M><K><S><L><T><W><I><L><G><L><W><A><L><A><A><C><F><T><P><G><E><S><Q><R><G><P><R><G><P><Y><P><P><G><P><L><A><P><P><P><P><P><C><F><P><F><G><T><G><F><V><P><P><P><H><P><P><P><Y><G><P><G><R><F><P><P><P><L><S><P><P><Y><G><P><G><R><I><P><P><S><P><P><P><P><Y><G><P><G><R><I><Q><S><H><S><L><P><P><P><Y><G><P><G><Y><P><Q><P><P><S><Q><P><R><P><Y><P><P><G><P><P><F><F><P><V><N><S><P><T><D><P><A><L><P><T><P><A><P> | May play a role in protection or detoxification.<BOP> | Q99954 |
Q9BX93 | PG12B_HUMAN | sPLA2-GXIIB | Homo | <M><K><L><A><S><G><F><L><V><L><W><L><S><L><G><G><G><L><A><Q><S><D><T><S><P><D><T><E><E><S><Y><S><D><W><G><L><R><H><L><R><G><S><F><E><S><V><N><S><Y><F><D><S><F><L><E><L><L><G><G><K><N><G><V><C><Q><Y><R><C><R><Y><G><K><A><P><M><P><R><P><G><Y><K><P><Q><E><P><N><G><C><G><S><Y><F><L><G><L><K><V><P><E><S><M><D><L><G><I><P><A><M><T><K><C><C><N><Q><L><D><V><C><Y><D><T><C><G><A><N><K><Y><R><C><D><A><K><F><R><W><C><L><H><S><I><C><S><D><L><K><R><S><L><G><F><V><S><K><V><E><A><A><C><D><S><L><V><D><T><V><F><N><T><V><W><T><L><G><C><R><P><F><M><N><S><Q><R><A><A><C><I><C><A><E><E><E><K><E><E><L> | Not known; does not seem to have catalytic activity.<BOP> | Q9BX93 |
Q8N543 | OGFD1_HUMAN | uS12 prolyl 3-hydroxylase | Homo | <M><N><G><K><R><P><A><E><P><G><P><A><R><V><G><K><K><G><K><K><E><V><M><A><E><F><S><D><A><V><T><E><E><T><L><K><K><Q><V><A><E><A><W><S><R><R><T><P><F><S><H><E><V><I><V><M><D><M><D><P><F><L><H><C><V><I><P><N><F><I><Q><S><Q><D><F><L><E><G><L><Q><K><E><L><M><N><L><D><F><H><E><K><Y><N><D><L><Y><K><F><Q><Q><S><D><D><L><K><K><R><R><E><P><H><I><S><T><L><R><K><I><L><F><E><D><F><R><S><W><L><S><D><I><S><K><I><D><L><E><S><T><I><D><M><S><C><A><K><Y><E><F><T><D><A><L><L><C><H><D><D><E><L><E><G><R><R><I><A><F><I><L><Y><L><V><P><P><W><D><R><S><M><G><G><T><L><D><L><Y><S><I><D><E><H><F><Q><P><K><Q><I><V><K><S><L><I><P><S><W><N><K><L><V><F><F><E><V><S><P><V><S><F><H><Q><V><S><E><V><L><S><E><E><K><S><R><L><S><I><S><G><W><F><H><G><P><S><L><T><R><P><P><N><Y><F><E><P><P><I><P><R><S><P><H><I><P><Q><D><H><E><I><L><Y><D><W><I><N><P><T><Y><L><D><M><D><Y><Q><V><Q><I><Q><E><E><F><E><E><S><S><E><I><L><L><K><E><F><L><K><P><E><K><F><T><K><V><C><E><A><L><E><H><G><H><V><E><W><S><S><R><G><P><P><N><K><R><F><Y><E><K><A><E><E><S><K><L><P><E><I><L><K><E><C><M><K><L><F><R><S><E><A><L><F><L><L><L><S><N><F><T><G><L><K><L><H><F><L><A><P><S><E><E><D><E><M><N><D><K><K><E><A><E><T><T><D><I><T><E><E><G><T><S><H><S><P><P><E><P><E><N><N><Q><M><A><I><S><N><N><S><Q><Q><S><N><E><Q><T><D><P><E><P><E><E><N><E><T><K><K><E><S><S><V><P><M><C><Q><G><E><L><R><H><W><K><T><G><H><Y><T><L><I><H><D><H><S><K><A><E><F><A><L><D><L><I><L><Y><C><G><C><E><G><W><E><P><E><Y><G><G><F><T><S><Y><I><A><K><G><E><D><E><E><L><L><T><V><N><P><E><S><N><S><L><A><L><V><Y><R><D><R><E><T><L><K><F><V><K><H><I><N><H><R><S><L><E><Q><K><K><T><F><P><N><R><T><G><F><W><D><F><S><F><I><Y><Y><E> | Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.<BOP> | Q8N543 |
Q6DRA6 | H2B2D_HUMAN | H2B-clustered histone 19 pseudogene | Homo | <M><P><E><P><A><K><F><A><P><A><P><K><K><G><S><K><K><A><V><T><K><A><Q><K><K><D><G><K><K><R><K><R><S><R><K><E><S><Y><S><I><Y><V><Y><K><V><L><K><R><V><H><P><D><T><G><I><W><C><K><A><M><G><I><M><N><S><F><L><N><D><I><F><E><R><I><A><G><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><R><S><R><R><P><C><A><C><C><C><P><A><S><W><P><S><T><P><C><P><R><A><P><R><R><S><P><S><T><P><A><P><S><E><S><L><P><G><P><G><A><R><S><L><P><P><S><L><P><P><R><V><A><G><C><F><V><S><K><G><S><F><Q><G><H><L><T><P><L><V><K> | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP> | Q6DRA6 |
Q8TEB7 | RN128_HUMAN | RING-type E3 ubiquitin transferase RNF128 | Homo | <M><G><P><P><P><G><A><G><V><S><C><R><G><G><C><G><F><S><R><L><L><A><W><C><F><L><L><A><L><S><P><Q><A><P><G><S><R><G><A><E><A><V><W><T><A><Y><L><N><V><S><W><R><V><P><H><T><G><V><N><R><T><V><W><E><L><S><E><E><G><V><Y><G><Q><D><S><P><L><E><P><V><A><G><V><L><V><P><P><D><G><P><G><A><L><N><A><C><N><P><H><T><N><F><T><V><P><T><V><W><G><S><T><V><Q><V><S><W><L><A><L><I><Q><R><G><G><G><C><T><F><A><D><K><I><H><L><A><Y><E><R><G><A><S><G><A><V><I><F><N><F><P><G><T><R><N><E><V><I><P><M><S><H><P><G><A><V><D><I><V><A><I><M><I><G><N><L><K><G><T><K><I><L><Q><S><I><Q><R><G><I><Q><V><T><M><V><I><E><V><G><K><K><H><G><P><W><V><N><H><Y><S><I><F><F><V><S><V><S><F><F><I><I><T><A><A><T><V><G><Y><F><I><F><Y><S><A><R><R><L><R><N><A><R><A><Q><S><R><K><Q><R><Q><L><K><A><D><A><K><K><A><I><G><R><L><Q><L><R><T><L><K><Q><G><D><K><E><I><G><P><D><G><D><S><C><A><V><C><I><E><L><Y><K><P><N><D><L><V><R><I><L><T><C><N><H><I><F><H><K><T><C><V><D><P><W><L><L><E><H><R><T><C><P><M><C><K><C><D><I><L><K><A><L><G><I><E><V><D><V><E><D><G><S><V><S><L><Q><V><P><V><S><N><E><I><S><N><S><A><S><S><H><E><E><D><N><R><S><E><T><A><S><S><G><Y><A><S><V><Q><G><T><D><E><P><P><L><E><E><H><V><Q><S><T><N><E><S><L><Q><L><V><N><H><E><A><N><S><V><A><V><D><V><I><P><H><V><D><N><P><T><F><E><E><D><E><T><P><N><Q><E><T><A><V><R><E><I><K><S> | E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.<BOP> | Q8TEB7 |
Q5TC12 | ATPF1_HUMAN | ATP11 homolog | Homo | <M><A><A><V><V><V><A><A><A><G><G><A><G><P><A><V><L><Q><V><A><G><L><Y><R><G><L><C><A><V><R><S><R><A><L><G><L><G><L><V><S><P><A><Q><L><R><V><F><P><V><R><P><G><S><G><R><P><E><G><G><A><D><S><S><G><V><G><A><E><A><E><L><Q><A><N><P><F><Y><D><R><Y><R><D><K><I><Q><L><L><R><R><S><D><P><A><A><F><E><S><R><L><E><K><R><S><E><F><R><K><Q><P><V><G><H><S><R><Q><G><D><F><I><K><C><V><E><Q><K><T><D><A><L><G><K><Q><S><V><N><R><G><F><T><K><D><K><T><L><S><S><I><F><N><I><E><M><V><K><E><K><T><A><E><E><I><K><Q><I><W><Q><Q><Y><F><A><A><K><D><T><V><Y><A><V><I><P><A><E><K><F><D><L><I><W><N><R><A><Q><S><C><P><T><F><L><C><A><L><P><R><R><E><G><Y><E><F><F><V><G><Q><W><T><G><T><E><L><H><F><T><A><L><I><N><I><Q><T><R><G><E><A><A><A><S><Q><L><I><L><Y><H><Y><P><E><L><K><E><E><K><G><I><V><L><M><T><A><E><M><D><S><T><F><L><N><V><A><E><A><Q><C><I><A><N><Q><V><Q><L><F><Y><A><T><D><R><K><E><T><Y><G><L><V><E><T><F><N><L><R><P><N><E><F><K><Y><M><S><V><I><A><E><L><E><Q><S><G><L><G><A><E><L><K><C><A><Q><N><Q><N><K><T> | May play an essential role for the assembly of the mitochondrial F1-F0 complex.<BOP> | Q5TC12 |
Q9BQE3 | TBA1C_HUMAN | Detyrosinated tubulin alpha-1C chain | Homo | <M><R><E><C><I><S><I><H><V><G><Q><A><G><V><Q><I><G><N><A><C><W><E><L><Y><C><L><E><H><G><I><Q><P><D><G><Q><M><P><S><D><K><T><I><G><G><G><D><D><S><F><N><T><F><F><S><E><T><G><A><G><K><H><V><P><R><A><V><F><V><D><L><E><P><T><V><I><D><E><V><R><T><G><T><Y><R><Q><L><F><H><P><E><Q><L><I><T><G><K><E><D><A><A><N><N><Y><A><R><G><H><Y><T><I><G><K><E><I><I><D><L><V><L><D><R><I><R><K><L><A><D><Q><C><T><G><L><Q><G><F><L><V><F><H><S><F><G><G><G><T><G><S><G><F><T><S><L><L><M><E><R><L><S><V><D><Y><G><K><K><S><K><L><E><F><S><I><Y><P><A><P><Q><V><S><T><A><V><V><E><P><Y><N><S><I><L><T><T><H><T><T><L><E><H><S><D><C><A><F><M><V><D><N><E><A><I><Y><D><I><C><R><R><N><L><D><I><E><R><P><T><Y><T><N><L><N><R><L><I><S><Q><I><V><S><S><I><T><A><S><L><R><F><D><G><A><L><N><V><D><L><T><E><F><Q><T><N><L><V><P><Y><P><R><I><H><F><P><L><A><T><Y><A><P><V><I><S><A><E><K><A><Y><H><E><Q><L><T><V><A><E><I><T><N><A><C><F><E><P><A><N><Q><M><V><K><C><D><P><R><H><G><K><Y><M><A><C><C><L><L><Y><R><G><D><V><V><P><K><D><V><N><A><A><I><A><T><I><K><T><K><R><T><I><Q><F><V><D><W><C><P><T><G><F><K><V><G><I><N><Y><Q><P><P><T><V><V><P><G><G><D><L><A><K><V><Q><R><A><V><C><M><L><S><N><T><T><A><V><A><E><A><W><A><R><L><D><H><K><F><D><L><M><Y><A><K><R><A><F><V><H><W><Y><V><G><E><G><M><E><E><G><E><F><S><E><A><R><E><D><M><A><A><L><E><K><D><Y><E><E><V><G><A><D><S><A><D><G><E><D><E><G><E><E><Y> | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.<BOP> | Q9BQE3 |
A0A1W2PR19 | GSTT4_HUMAN | Glutathione S-transferase theta pseudogene 1 | Homo | <M><A><L><E><L><Y><M><D><L><L><S><A><P><C><R><A><V><Y><I><F><S><K><K><H><D><I><Q><F><N><F><Q><F><V><D><L><L><K><G><H><H><H><S><K><G><Y><I><D><I><N><P><L><R><K><L><P><S><L><K><D><G><K><F><I><L><S><E><S><A><A><I><L><Y><Y><L><C><R><K><Y><S><A><P><S><H><W><C><P><P><D><P><H><A><R><A><R><V><D><E><F><V><A><W><Q><H><T><A><F><Q><L><P><M><K><K><I><V><W><L><K><L><L><I><P><K><I><T><G><E><E><V><S><A><E><K><M><E><H><A><V><E><E><V><K><N><S><L><Q><L><F><E><E><Y><F><L><Q><D><K><M><F><I><T><G><N><Q><I><S><L><A><D><L><V><A><V><V><E><M><M><Q><P><M><A><A><N><Y><N><V><F><L><N><S><S><K><L><A><E><W><R><M><Q><V><E><L><N><I><G><S><G><L><F><R><E><A><H><D><R><L><M><Q><L><A><D><W><D><F><S><T><L><D><S><M><V><K><E><N><I><S><E><L><L><K><K><S><R> | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<BOP> | A0A1W2PR19 |
Q9BRD0 | BUD13_HUMAN | BUD13 homolog | Homo | <M><A><A><A><P><P><L><S><K><A><E><Y><L><K><R><Y><L><S><G><A><D><A><G><V><D><R><G><S><E><S><G><R><K><R><R><K><K><R><P><K><P><G><G><A><G><G><K><G><M><R><I><V><D><D><D><V><S><W><T><A><I><S><T><T><K><L><E><K><E><E><E><E><D><D><G><D><L><P><V><V><A><E><F><V><D><E><R><P><E><E><V><K><Q><M><E><A><F><R><S><S><A><K><W><K><L><L><G><G><H><N><E><D><L><P><S><N><R><H><F><R><H><D><T><P><D><S><S><P><R><R><V><R><H><G><T><P><D><P><S><P><R><K><D><R><H><D><T><P><D><P><S><P><R><R><A><R><H><D><T><P><D><P><S><P><L><R><G><A><R><H><D><S><D><T><S><P><P><R><R><I><R><H><D><S><S><D><T><S><P><P><R><R><A><R><H><D><S><P><D><P><S><P><P><R><R><P><Q><H><N><S><S><G><A><S><P><R><R><V><R><H><D><S><P><D><P><S><P><P><R><R><A><R><H><G><S><S><D><I><S><S><P><R><R><V><H><N><N><S><P><D><T><S><R><R><T><L><G><S><S><D><T><Q><Q><L><R><R><A><R><H><D><S><P><D><L><A><P><N><V><T><Y><S><L><P><R><T><K><S><G><K><A><P><E><R><A><S><S><K><T><S><P><H><W><K><E><S><G><A><S><H><L><S><F><P><K><N><S><K><Y><E><Y><D><P><D><I><S><P><P><R><K><K><Q><A><K><S><H><F><G><D><K><K><Q><L><D><S><K><G><D><C><Q><K><A><T><D><S><D><L><S><S><P><R><H><K><Q><S><P><G><H><Q><D><S><D><S><D><L><S><P><P><R><N><R><P><R><H><R><S><S><D><S><D><L><S><P><P><R><R><R><Q><R><T><K><S><S><D><S><D><L><S><P><P><R><R><S><Q><P><P><G><K><K><A><A><H><M><Y><S><G><A><K><T><G><L><V><L><T><D><I><Q><R><E><Q><Q><E><L><K><E><Q><D><Q><E><T><M><A><F><E><A><E><F><Q><Y><A><E><T><V><F><R><D><K><S><G><R><K><R><N><L><K><L><E><R><L><E><Q><R><R><K><A><E><K><D><S><E><R><D><E><L><Y><A><Q><W><G><K><G><L><A><Q><S><R><Q><Q><Q><Q><N><V><E><D><A><M><K><E><M><Q><K><P><L><A><R><Y><I><D><D><E><D><L><D><R><M><L><R><E><Q><E><R><E><G><D><P><M><A><N><F><I><K><K><N><K><A><K><E><N><K><N><K><K><V><R><P><R><Y><S><G><P><A><P><P><P><N><R><F><N><I><W><P><G><Y><R><W><D><G><V><D><R><S><N><G><F><E><Q><K><R><F><A><R><L><A><S><K><K><A><V><E><E><L><A><Y><K><W><S><V><E><D><M> | Involved in pre-mRNA splicing as component of the activated spliceosome.<BOP> | Q9BRD0 |
Q9NZP8 | C1RL_HUMAN | C1r-like serine protease analog protein | Homo | <M><P><G><P><R><V><W><G><K><Y><L><W><R><S><P><H><S><K><G><C><P><G><A><M><W><W><L><L><L><W><G><V><L><Q><A><C><P><T><R><G><S><V><L><L><A><Q><E><L><P><Q><Q><L><T><S><P><G><Y><P><E><P><Y><G><K><G><Q><E><S><S><T><D><I><K><A><P><E><G><F><A><V><R><L><V><F><Q><D><F><D><L><E><P><S><Q><D><C><A><G><D><S><V><T><I><S><F><V><G><S><D><P><S><Q><F><C><G><Q><Q><G><S><P><L><G><R><P><P><G><Q><R><E><F><V><S><S><G><R><S><L><R><L><T><F><R><T><Q><P><S><S><E><N><K><T><A><H><L><H><K><G><F><L><A><L><Y><Q><T><V><A><V><N><Y><S><Q><P><I><S><E><A><S><R><G><S><E><A><I><N><A><P><G><D><N><P><A><K><V><Q><N><H><C><Q><E><P><Y><Y><Q><A><A><A><A><G><A><L><T><C><A><T><P><G><T><W><K><D><R><Q><D><G><E><E><V><L><Q><C><M><P><V><C><G><R><P><V><T><P><I><A><Q><N><Q><T><T><L><G><S><S><R><A><K><L><G><N><F><P><W><Q><A><F><T><S><I><H><G><R><G><G><G><A><L><L><G><D><R><W><I><L><T><A><A><H><T><I><Y><P><K><D><S><V><S><L><R><K><N><Q><S><V><N><V><F><L><G><H><T><A><I><D><E><M><L><K><L><G><N><H><P><V><H><R><V><V><V><H><P><D><Y><R><Q><N><E><S><H><N><F><S><G><D><I><A><L><L><E><L><Q><H><S><I><P><L><G><P><N><V><L><P><V><C><L><P><D><N><E><T><L><Y><R><S><G><L><L><G><Y><V><S><G><F><G><M><E><M><G><W><L><T><T><E><L><K><Y><S><R><L><P><V><A><P><R><E><A><C><N><A><W><L><Q><K><R><Q><R><P><E><V><F><S><D><N><M><F><C><V><G><D><E><T><Q><R><H><S><V><C><Q><G><D><S><G><S><V><Y><V><V><W><D><N><H><A><H><H><W><V><A><T><G><I><V><S><W><G><I><G><C><G><E><G><Y><D><F><Y><T><K><V><L><S><Y><V><D><W><I><K><G><V><M><N><G><K><N> | Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.<BOP> | Q9NZP8 |
Q9P1Z2 | CACO1_HUMAN | Sarcoma antigen NY-SAR-3 | Homo | <M><E><E><S><P><L><S><R><A><P><S><R><G><G><V><N><F><L><N><V><A><R><T><Y><I><P><N><T><K><V><E><C><H><Y><T><L><P><P><G><T><M><P><S><A><S><D><W><I><G><I><F><K><V><E><A><A><C><V><R><D><Y><H><T><F><V><W><S><S><V><P><E><S><T><T><D><G><S><P><I><H><T><S><V><Q><F><Q><A><S><Y><L><P><K><P><G><A><Q><L><Y><Q><F><R><Y><V><N><R><Q><G><Q><V><C><G><Q><S><P><P><F><Q><F><R><E><P><R><P><M><D><E><L><V><T><L><E><E><A><D><G><G><S><D><I><L><L><V><V><P><K><A><T><V><L><Q><N><Q><L><D><E><S><Q><Q><E><R><N><D><L><M><Q><L><K><L><Q><L><E><G><Q><V><T><E><L><R><S><R><V><Q><E><L><E><R><A><L><A><T><A><R><Q><E><H><T><E><L><M><E><Q><Y><K><G><I><S><R><S><H><G><E><I><T><E><E><R><D><I><L><S><R><Q><Q><G><D><H><V><A><R><I><L><E><L><E><D><D><I><Q><T><I><S><E><K><V><L><T><K><E><V><E><L><D><R><L><R><D><T><V><K><A><L><T><R><E><Q><E><K><L><L><G><Q><L><K><E><V><Q><A><D><K><E><Q><S><E><A><E><L><Q><V><A><Q><Q><E><N><H><H><L><N><L><D><L><K><E><A><K><S><W><Q><E><E><Q><S><A><Q><A><Q><R><L><K><D><K><V><A><Q><M><K><D><T><L><G><Q><A><Q><Q><R><V><A><E><L><E><P><L><K><E><Q><L><R><G><A><Q><E><L><A><A><S><S><Q><Q><K><A><T><L><L><G><E><E><L><A><S><A><A><A><A><R><D><R><T><I><A><E><L><H><R><S><R><L><E><V><A><E><V><N><G><R><L><A><E><L><G><L><H><L><K><E><E><K><C><Q><W><S><K><E><R><A><G><L><L><Q><S><V><E><A><E><K><D><K><I><L><K><L><S><A><E><I><L><R><L><E><K><A><V><Q><E><E><R><T><Q><N><Q><V><F><K><T><E><L><A><R><E><K><D><S><S><L><V><Q><L><S><E><S><K><R><E><L><T><E><L><R><S><A><L><R><V><L><Q><K><E><K><E><Q><L><Q><E><E><K><Q><E><L><L><E><Y><M><R><K><L><E><A><R><L><E><K><V><A><D><E><K><W><N><E><D><A><T><T><E><D><E><E><A><A><V><G><L><S><C><P><A><A><L><T><D><S><E><D><E><S><P><E><D><M><R><L><P><P><Y><G><L><C><E><R><G><D><P><G><S><S><P><A><G><P><R><E><A><S><P><L><V><V><I><S><Q><P><A><P><I><S><P><H><L><S><G><P><A><E><D><S><S><S><D><S><E><A><E><D><E><K><S><V><L><M><A><A><V><Q><S><G><G><E><E><A><N><L><L><L><P><E><L><G><S><A><F><Y><D><M><A><S><G><F><T><V><G><T><L><S><E><T><S><T><G><G><P><A><T><P><T><W><K><E><C><P><I><C><K><E><R><F><P><A><E><S><D><K><D><A><L><E><D><H><M><D><G><H><F><F><F><S><T><Q><D><P><F><T><F><E> | Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.<BOP> | Q9P1Z2 |
Q9Y3Q3 | TMED3_HUMAN | p26 | Homo | <M><G><S><T><V><P><R><S><A><S><V><L><L><L><L><L><L><L><R><R><A><E><Q><P><C><G><A><E><L><T><F><E><L><P><D><N><A><K><Q><C><F><H><E><E><V><E><Q><G><V><K><F><S><L><D><Y><Q><V><I><T><G><G><H><Y><D><V><D><C><Y><V><E><D><P><Q><G><N><T><I><Y><R><E><T><K><K><Q><Y><D><S><F><T><Y><R><A><E><V><K><G><V><Y><Q><F><C><F><S><N><E><F><S><T><F><S><H><K><T><V><Y><F><D><F><Q><V><G><D><E><P><P><I><L><P><D><M><G><N><R><V><T><A><L><T><Q><M><E><S><A><C><V><T><I><H><E><A><L><K><T><V><I><D><S><Q><T><H><Y><R><L><R><E><A><Q><D><R><A><R><A><E><D><L><N><S><R><V><S><Y><W><S><V><G><E><T><I><A><L><F><V><V><S><F><S><Q><V><L><L><L><K><S><F><F><T><E><K><R><P><I><S><R><A><V><H><S> | Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network.<BOP> | Q9Y3Q3 |
Q8TAU3 | ZN417_HUMAN | Zinc finger protein 417 | Homo | <M><A><A><A><A><P><R><R><P><T><Q><Q><G><T><V><T><F><E><D><V><A><V><N><F><S><Q><E><E><W><C><L><L><S><E><A><Q><R><C><L><Y><R><D><V><M><L><E><N><L><A><L><I><S><S><L><G><C><W><C><G><S><K><D><E><E><A><P><C><K><Q><R><I><S><V><Q><R><E><S><Q><S><R><T><P><R><A><G><V><S><P><K><K><A><H><P><C><E><M><C><G><L><I><L><E><D><V><F><H><F><A><D><H><Q><E><T><H><H><K><Q><K><L><N><R><S><G><A><C><G><K><N><L><D><D><T><A><Y><L><H><Q><H><Q><K><Q><H><I><G><E><K><F><Y><R><K><S><V><R><E><A><S><F><V><K><K><R><K><L><R><V><S><Q><E><P><F><V><F><R><E><F><G><K><D><V><L><P><S><S><G><L><C><Q><E><A><A><A><V><E><K><T><D><S><E><T><M><H><G><P><P><F><Q><E><G><K><T><N><Y><S><C><G><K><R><T><K><A><F><S><T><K><H><S><V><I><P><H><Q><K><L><F><T><R><D><G><C><Y><V><C><S><D><C><G><K><S><F><S><R><Y><V><S><F><S><N><H><Q><R><D><H><T><A><K><G><P><Y><D><C><G><E><C><G><K><S><Y><S><R><K><S><S><L><I><Q><H><Q><R><V><H><T><G><K><T><A><Y><P><C><E><E><C><G><K><S><F><S><Q><K><G><S><L><I><S><H><Q><R><V><H><T><G><E><R><P><Y><E><C><R><E><Y><G><K><S><F><G><Q><K><G><N><L><I><Q><H><Q><Q><G><H><T><G><E><R><A><Y><H><C><G><E><C><G><K><S><F><R><Q><K><F><C><F><I><N><H><Q><R><V><H><T><G><E><R><P><Y><K><C><G><E><C><G><K><S><F><G><Q><K><G><N><L><V><Q><H><Q><R><G><H><T><G><E><R><P><Y><E><C><K><E><C><G><K><S><F><R><Y><R><S><H><L><T><E><H><Q><R><L><H><T><G><E><R><P><Y><N><C><R><E><C><G><K><L><F><N><R><K><Y><H><L><L><V><H><E><R><V><H><T><G><E><R><P><Y><A><C><E><V><C><G><K><L><F><G><N><K><N><C><V><T><I><H><Q><R><I><H><T><G><E><R><P><Y><E><C><N><E><C><G><K><S><F><L><S><S><S><A><L><H><V><H><K><R><V><H><S><G><Q><K><P><Y><K><C><S><E><C><G><K><S><F><A><E><C><S><S><L><I><K><H><R><R><I><H><T><G><E><R><P><Y><E><C><T><K><C><G><K><T><F><Q><R><S><S><T><L><L><H><H><Q><S><S><H><R><R><K><A><L> | May be involved in transcriptional regulation.<BOP> | Q8TAU3 |
Q9BXY8 | BEX2_HUMAN | Brain-expressed X-linked protein 2 | Homo | <M><E><S><K><E><E><R><A><L><N><N><L><I><V><E><N><V><N><Q><E><N><D><E><K><D><E><K><E><Q><V><A><N><K><G><E><P><L><A><L><P><L><N><V><S><E><Y><C><V><P><R><G><N><R><R><R><F><R><V><R><Q><P><I><L><Q><Y><R><W><D><I><M><H><R><L><G><E><P><Q><A><R><M><R><E><E><N><M><E><R><I><G><E><E><V><R><Q><L><M><E><K><L><R><E><K><Q><L><S><H><S><L><R><A><V><S><T><D><P><P><H><H><D><H><H><D><E><F><C><L><M><P> | Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.<BOP> | Q9BXY8 |
Q86WB0 | ZC3C1_HUMAN | Nuclear-interacting partner of anaplastic lymphoma kinase | Homo | <M><A><A><P><C><E><G><Q><A><F><A><V><G><V><E><K><N><W><G><A><V><V><R><S><P><E><G><T><P><Q><K><I><R><Q><L><I><D><E><G><I><A><P><E><E><G><G><V><D><A><K><D><T><S><A><T><S><Q><S><V><N><G><S><P><Q><A><E><Q><P><S><L><E><S><T><S><K><E><A><F><F><S><R><V><E><T><F><S><S><L><K><W><A><G><K><P><F><E><L><S><P><L><V><C><A><K><Y><G><W><V><T><V><E><C><D><M><L><K><C><S><S><C><Q><A><F><L><C><A><S><L><Q><P><A><F><D><F><D><R><Y><K><Q><R><C><A><E><L><K><K><A><L><C><T><A><H><E><K><F><C><F><W><P><D><S><P><S><P><D><R><F><G><M><L><P><L><D><E><P><A><I><L><V><S><E><F><L><D><R><F><Q><S><L><C><H><L><D><L><Q><L><P><S><L><R><P><E><D><L><K><T><M><C><L><T><E><D><K><I><S><L><L><L><H><L><L><E><D><E><L><D><H><R><T><D><E><R><K><T><T><I><K><L><G><S><D><I><Q><V><H><V><T><A><C><I><L><S><V><C><G><W><A><C><S><S><S><L><E><S><M><Q><L><S><L><I><T><C><S><Q><C><M><R><K><V><G><L><W><G><F><Q><Q><I><E><S><S><M><T><D><L><D><A><S><F><G><L><T><S><S><P><I><P><G><L><E><G><R><P><E><R><L><P><L><V><P><E><S><P><R><R><M><M><T><R><S><Q><D><A><T><F><S><P><G><S><E><Q><A><E><K><S><P><G><P><I><V><S><R><T><R><S><W><D><S><S><S><P><V><D><R><P><E><P><E><A><A><S><P><T><T><R><T><R><P><V><T><R><S><M><G><T><G><D><T><P><G><L><E><V><P><S><S><P><L><R><K><A><K><R><A><R><L><C><S><S><S><S><S><D><T><S><S><R><S><F><F><D><P><T><S><Q><H><R><D><W><C><P><W><V><N><I><T><L><G><K><E><S><R><E><N><G><G><T><E><P><D><A><S><A><P><A><E><P><G><W><K><A><V><L><T><I><L><L><A><H><K><Q><S><S><Q><P><A><E><T><D><S><M><S><L><S><E><K><S><R><K><V><F><R><I><F><R><Q><W><E><S><L><C><S><C> | Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.<BOP> | Q86WB0 |
Q92826 | HXB13_HUMAN | Homeobox protein Hox-B13 | Homo | <M><E><P><G><N><Y><A><T><L><D><G><A><K><D><I><E><G><L><L><G><A><G><G><G><R><N><L><V><A><H><S><P><L><T><S><H><P><A><A><P><T><L><M><P><A><V><N><Y><A><P><L><D><L><P><G><S><A><E><P><P><K><Q><C><H><P><C><P><G><V><P><Q><G><T><S><P><A><P><V><P><Y><G><Y><F><G><G><G><Y><Y><S><C><R><V><S><R><S><S><L><K><P><C><A><Q><A><A><T><L><A><A><Y><P><A><E><T><P><T><A><G><E><E><Y><P><S><R><P><T><E><F><A><F><Y><P><G><Y><P><G><T><Y><Q><P><M><A><S><Y><L><D><V><S><V><V><Q><T><L><G><A><P><G><E><P><R><H><D><S><L><L><P><V><D><S><Y><Q><S><W><A><L><A><G><G><W><N><S><Q><M><C><C><Q><G><E><Q><N><P><P><G><P><F><W><K><A><A><F><A><D><S><S><G><Q><H><P><P><D><A><C><A><F><R><R><G><R><K><K><R><I><P><Y><S><K><G><Q><L><R><E><L><E><R><E><Y><A><A><N><K><F><I><T><K><D><K><R><R><K><I><S><A><A><T><S><L><S><E><R><Q><I><T><I><W><F><Q><N><R><R><V><K><E><K><K><V><L><A><K><V><K><N><S><A><T><P> | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA .<BOP> | Q92826 |
Q9H628 | RERGL_HUMAN | RERG/Ras-like protein | Homo | <M><S><N><F><L><H><L><K><Y><N><E><K><S><V><S><V><T><K><A><L><T><V><R><F><L><T><K><R><F><I><G><E><Y><A><S><N><F><E><S><I><Y><K><K><H><L><C><L><E><R><K><Q><L><N><L><E><I><Y><D><P><C><S><Q><T><Q><K><A><K><F><S><L><T><S><E><L><H><W><A><D><G><F><V><I><V><Y><D><I><S><D><R><S><S><F><A><F><A><K><A><L><I><Y><R><I><R><E><P><Q><T><S><H><C><K><R><A><V><E><S><A><V><F><L><V><G><N><K><R><D><L><C><H><V><R><E><V><G><W><E><E><G><Q><K><L><A><L><E><N><R><C><Q><F><C><E><L><S><A><A><E><Q><S><L><E><V><E><M><M><F><I><R><I><I><K><D><I><L><I><N><F><K><L><K><E><K><R><R><P><S><G><S><K><S><M><A><K><L><I><N><N><V><F><G><K><R><R><K><S><V> | Binds GDP/GTP and may possess intrinsic GTPase activity.<BOP> | Q9H628 |
O95273 | CCDB1_HUMAN | Human homolog of Maid | Homo | <M><A><S><A><T><A><P><A><A><A><V><P><T><L><A><S><P><L><E><Q><L><R><H><L><A><E><E><L><R><L><L><L><P><R><V><R><V><G><E><A><Q><E><T><T><E><E><F><N><R><E><M><F><W><R><R><L><N><E><A><A><V><T><V><S><R><E><A><T><T><L><T><I><V><F><S><Q><L><P><L><P><S><P><Q><E><T><Q><K><F><C><E><Q><V><H><A><A><I><K><A><F><I><A><V><Y><Y><L><L><P><K><D><Q><G><I><T><L><R><K><L><V><R><G><A><T><L><D><I><V><D><G><M><A><Q><L><M><E><V><L><S><V><T><P><T><Q><S><P><E><N><N><D><L><I><S><Y><N><S><V><W><V><A><C><Q><Q><M><P><Q><I><P><R><D><N><K><A><A><A><L><L><M><L><T><K><N><V><D><F><V><K><D><A><H><E><E><M><E><Q><A><V><E><E><C><D><P><Y><S><G><L><L><N><D><T><E><E><N><N><S><D><N><H><N><H><E><D><D><V><L><G><F><P><S><N><Q><D><L><Y><W><S><E><D><D><Q><E><L><I><I><P><C><L><A><L><V><R><A><S><K><A><C><L><K><K><I><R><M><L><V><A><E><N><G><K><K><D><Q><V><A><Q><L><D><D><I><V><D><I><S><D><E><I><S><P><S><V><D><D><L><A><L><S><I><Y><P><P><M><C><H><L><T><V><R><I><N><S><A><K><L><V><S><V><L><K><K><A><L><E><I><T><K><A><S><H><V><T><P><Q><P><E><D><S><W><I><P><L><L><I><N><A><I><D><H><C><M><N><R><I><K><E><L><T><Q><S><E><L><E><L> | May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.<BOP> | O95273 |
P0CK96 | S352B_HUMAN | Solute carrier family 35 member E2B | Homo | <M><S><S><S><V><K><T><P><A><L><E><E><L><V><P><G><S><E><E><K><P><K><G><R><S><P><L><S><W><G><S><L><F><G><H><R><S><E><K><I><V><F><A><K><S><D><G><G><T><D><E><N><V><L><T><V><T><I><T><E><T><T><V><I><E><S><D><L><G><V><W><S><S><R><A><L><L><Y><L><T><L><W><F><F><F><S><F><C><T><L><F><L><N><K><Y><I><L><S><L><L><G><G><E><P><S><M><L><G><A><V><Q><M><L><S><T><T><V><I><G><C><V><K><T><L><V><P><C><C><L><Y><Q><H><K><A><R><L><S><Y><P><P><N><F><L><M><T><M><L><F><V><G><L><M><R><F><A><T><V><V><L><G><L><V><S><L><K><N><V><A><V><S><F><A><E><T><V><K><S><S><A><P><I><F><T><V><I><M><S><R><M><I><L><G><E><Y><T><G><L><L><V><N><L><S><L><I><P><V><M><G><G><L><A><L><C><T><A><T><E><I><S><F><N><V><L><G><F><S><A><A><L><S><T><N><I><M><D><C><L><Q><N><V><F><S><K><K><L><L><S><G><D><K><Y><R><F><S><A><P><E><L><Q><F><Y><T><S><A><A><A><V><A><M><L><V><P><A><R><V><F><F><T><D><V><P><V><I><G><R><S><G><K><S><F><S><Y><N><Q><D><V><V><L><L><L><L><T><D><G><V><L><F><H><L><Q><S><V><T><A><Y><A><L><M><G><K><I><S><P><V><T><F><S><V><A><S><T><V><K><H><A><L><S><I><W><L><S><V><I><V><F><G><N><K><I><T><S><L><S><A><V><G><T><A><L><V><T><V><G><V><L><L><Y><N><K><A><R><Q><H><Q><Q><E><A><L><Q><S><L><A><A><A><T><G><R><A><P><D><D><T><V><E><P><L><L><P><Q><D><P><R><Q><H><P> | Putative transporter.<BOP> | P0CK96 |
Q9C086 | IN80B_HUMAN | Zinc finger HIT domain-containing protein 4 | Homo | <M><S><K><L><W><R><R><G><S><T><S><G><A><M><E><A><P><E><P><G><E><A><L><E><L><S><L><A><G><A><H><G><H><G><V><H><K><K><K><H><K><K><H><K><K><K><H><K><K><K><H><H><Q><E><E><D><A><G><P><T><Q><P><S><P><A><K><P><Q><L><K><L><K><I><K><L><G><G><Q><V><L><G><T><K><S><V><P><T><F><T><V><I><P><E><G><P><R><S><P><S><P><L><M><V><V><D><N><E><E><E><P><M><E><G><V><P><L><E><Q><Y><R><A><W><L><D><E><D><S><N><L><S><P><S><P><L><R><D><L><S><G><G><L><G><G><Q><E><E><E><E><E><Q><R><W><L><D><A><L><E><K><G><E><L><D><D><N><G><D><L><K><K><E><I><N><E><R><L><L><T><A><R><Q><R><A><L><L><Q><K><A><R><S><Q><P><S><P><M><L><P><L><P><V><A><E><G><C><P><P><P><A><L><T><E><E><M><L><L><K><R><E><E><R><A><R><K><R><R><L><Q><A><A><R><R><A><E><E><H><K><N><Q><T><I><E><R><L><T><K><T><A><A><T><S><G><R><G><G><R><G><G><A><R><G><E><R><R><G><G><R><A><A><A><P><A><P><M><V><R><Y><C><S><G><A><Q><G><S><T><L><S><F><P><P><G><V><P><A><P><T><A><V><S><Q><R><P><S><P><S><G><P><P><P><R><C><S><V><P><G><C><P><H><P><R><R><Y><A><C><S><R><T><G><Q><A><L><C><S><L><Q><C><Y><R><I><N><L><Q><M><R><L><G><G><P><E><G><P><G><S><P><L><L><A><T> | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.<BOP> | Q9C086 |
Q8WUU5 | GATD1_HUMAN | Ocular development-associated gene protein | Homo | <M><P><L><G><L><K><P><T><C><S><V><C><K><T><T><S><S><S><M><W><K><K><G><A><Q><G><E><I><L><C><H><H><C><T><G><R><G><G><A><G><S><G><G><A><G><S><G><A><A><G><G><T><G><G><S><G><G><G><G><F><G><A><A><T><F><A><S><T><S><A><T><P><P><Q><S><N><G><G><G><G><G><K><Q><S><K><Q><E><I><H><R><R><S><A><R><L><R><N><T><K><Y><K><S><A><P><A><A><E><K><K><V><S><T><K><G><K><G><R><R><H><I><F><K><L><K><N><P><I><K><A><P><E><S><V><S><T><I><I><T><A><E><S><I><F><Y><K><G><V><Y><Y><Q><I><G><D><V><V><S><V><I><D><E><Q><D><G><K><P><Y><Y><A><Q><I><R><G><F><I><Q><D><Q><Y><C><E><K><S><A><A><L><T><W><L><I><P><T><L><S><S><P><R><D><Q><F><D><P><A><S><Y><I><I><G><P><E><E><D><L><P><R><K><M><E><Y><L><E><F><V><C><H><A><P><S><E><Y><F><K><S><R><S><S><P><F><P><T><V><P><T><R><P><E><K><G><Y><I><W><T><H><V><G><P><T><P><A><I><T><I><K><E><S><V><A><N><H><L> | Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3).<BOP> | Q8WUU5 |
Q6PEX3 | KR261_HUMAN | Keratin-associated protein 26-1 | Homo | <M><S><C><P><N><Y><C><S><G><N><S><N><S><G><S><L><R><T><S><R><H><I><P><L><T><S><I><D><L><C><P><T><S><V><S><C><G><D><V><L><Y><L><P><T><S><S><Q><D><H><T><W><V><T><D><N><C><Q><E><T><C><G><E><P><T><S><C><Q><P><V><H><C><E><T><G><N><L><E><T><S><C><G><S><S><T><A><Y><Y><V><P><R><P><C><Q><G><S><S><F><L><P><A><S><F><F><S><S><S><C><L><P><V><S><C><R><P><Q><R><Y><V><S><S><G><C><R><P><L><R><P><L><L><N><S><Y><Q><P><I><G><D><C><V><P><N><A><Y><R><P><Q><F><C><L><S><K><S><C><Q><P><Q><N><L><L><T><S><G><C><Q><P><S><S><C><L><A><Y><R><P><Q><S><L><H><V><V><S><S><S><L><R><P><L><G><P><L><F><S><G><C><Q><P><L><T><H><V><F><S><T><C><R><P><S><C><S><G><L> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q6PEX3 |
Q08397 | LOXL1_HUMAN | Lysyl oxidase-like protein 1 | Homo | <M><A><L><A><R><G><S><R><Q><L><G><A><L><V><W><G><A><C><L><C><V><L><V><H><G><Q><Q><A><Q><P><G><Q><G><S><D><P><A><R><W><R><Q><L><I><Q><W><E><N><N><G><Q><V><Y><S><L><L><N><S><G><S><E><Y><V><P><A><G><P><Q><R><S><E><S><S><S><R><V><L><L><A><G><A><P><Q><A><Q><Q><R><R><S><H><G><S><P><R><R><R><Q><A><P><S><L><P><L><P><G><R><V><G><S><D><T><V><R><G><Q><A><R><H><P><F><G><F><G><Q><V><P><D><N><W><R><E><V><A><V><G><D><S><T><G><M><A><R><A><R><T><S><V><S><Q><Q><R><H><G><G><S><A><S><S><V><S><A><S><A><F><A><S><T><Y><R><Q><Q><P><S><Y><P><Q><Q><F><P><Y><P><Q><A><P><F><V><S><Q><Y><E><N><Y><D><P><A><S><R><T><Y><D><Q><G><F><V><Y><Y><R><P><A><G><G><G><V><G><A><G><A><A><A><V><A><S><A><G><V><I><Y><P><Y><Q><P><R><A><R><Y><E><E><Y><G><G><G><E><E><L><P><E><Y><P><P><Q><G><F><Y><P><A><P><E><R><P><Y><V><P><P><P><P><P><P><P><D><G><L><D><R><R><Y><S><H><S><L><Y><S><E><G><T><P><G><F><E><Q><A><Y><P><D><P><G><P><E><A><A><Q><A><H><G><G><D><P><R><L><G><W><Y><P><P><Y><A><N><P><P><P><E><A><Y><G><P><P><R><A><L><E><P><P><Y><L><P><V><R><S><S><D><T><P><P><P><G><G><E><R><N><G><A><Q><Q><G><R><L><S><V><G><S><V><Y><R><P><N><Q><N><G><R><G><L><P><D><L><V><P><D><P><N><Y><V><Q><A><S><T><Y><V><Q><R><A><H><L><Y><S><L><R><C><A><A><E><E><K><C><L><A><S><T><A><Y><A><P><E><A><T><D><Y><D><V><R><V><L><L><R><F><P><Q><R><V><K><N><Q><G><T><A><D><F><L><P><N><R><P><R><H><T><W><E><W><H><S><C><H><Q><H><Y><H><S><M><D><E><F><S><H><Y><D><L><L><D><A><A><T><G><K><K><V><A><E><G><H><K><A><S><F><C><L><E><D><S><T><C><D><F><G><N><L><K><R><Y><A><C><T><S><H><T><Q><G><L><S><P><G><C><Y><D><T><Y><N><A><D><I><D><C><Q><W><I><D><I><T><D><V><Q><P><G><N><Y><I><L><K><V><H><V><N><P><K><Y><I><V><L><E><S><D><F><T><N><N><V><V><R><C><N><I><H><Y><T><G><R><Y><V><S><A><T><N><C><K><I><V><Q><S> | Active on elastin and collagen substrates.<BOP> | Q08397 |
Q8TBP0 | TBC16_HUMAN | TBC1 domain family member 16 | Homo | <M><S><L><G><R><L><L><R><R><A><S><S><K><A><S><D><L><L><T><L><T><P><G><G><S><G><S><G><S><P><S><V><L><D><G><E><I><I><Y><S><K><N><N><V><C><V><H><P><P><E><G><L><Q><G><L><G><E><H><H><P><G><Y><L><C><L><Y><M><E><K><D><E><M><L><G><A><T><L><I><L><A><W><V><P><N><S><R><I><Q><R><Q><D><E><E><A><L><R><Y><I><T><P><E><S><S><P><V><R><K><A><P><R><P><R><G><R><R><T><R><S><S><G><A><S><H><Q><P><S><P><T><E><L><R><P><T><L><T><P><K><D><E><D><I><L><V><V><A><Q><S><V><P><D><R><M><L><A><S><P><A><P><E><D><E><E><K><L><A><Q><G><L><G><V><D><G><A><Q><P><A><S><Q><P><A><C><S><P><S><G><I><L><S><T><V><S><P><Q><D><V><T><E><E><G><R><E><P><R><P><E><A><G><E><E><D><G><S><L><E><L><S><A><E><G><V><S><R><D><S><S><F><D><S><D><S><D><T><F><S><S><P><F><C><L><S><P><I><S><A><A><L><A><E><S><R><G><S><V><F><L><E><S><D><S><S><P><P><S><S><S><D><A><G><L><R><F><P><D><S><N><G><L><L><Q><T><P><R><W><D><E><P><Q><R><V><C><A><L><E><Q><I><C><G><V><F><R><V><D><L><G><H><M><R><S><L><R><L><F><F><S><D><E><A><C><T><S><G><Q><L><V><V><A><S><R><E><S><Q><Y><K><V><F><H><F><H><H><G><G><L><D><K><L><S><D><V><F><Q><Q><W><K><Y><C><T><E><M><Q><L><K><D><Q><Q><V><A><P><D><K><T><C><M><Q><F><S><I><R><R><P><K><L><P><S><S><E><T><H><P><E><E><S><M><Y><K><R><L><G><V><S><A><W><L><N><H><L><N><E><L><G><Q><V><E><E><E><Y><K><L><R><K><A><I><F><F><G><G><I><D><V><S><I><R><G><E><V><W><P><F><L><L><R><Y><Y><S><H><E><S><T><S><E><E><R><E><A><L><R><L><Q><K><R><K><E><Y><S><E><I><Q><Q><K><R><L><S><M><T><P><E><E><H><R><A><F><W><R><N><V><Q><F><T><V><D><K><D><V><V><R><T><D><R><N><N><Q><F><F><R><G><E><D><N><P><N><V><E><S><M><R><R><I><L><L><N><Y><A><V><Y><N><P><A><V><G><Y><S><Q><G><M><S><D><L><V><A><P><I><L><A><E><V><L><D><E><S><D><T><F><W><C><F><V><G><L><M><Q><N><T><I><F><V><S><S><P><R><D><E><D><M><E><K><Q><L><L><Y><L><R><E><L><L><R><L><T><H><V><R><F><Y><Q><H><L><V><S><L><G><E><D><G><L><Q><M><L><F><C><H><R><W><L><L><L><C><F><K><R><E><F><P><E><A><E><A><L><R><I><W><E><A><C><W><A><H><Y><Q><T><D><Y><F><H><L><F><I><C><V><A><I><V><A><I><Y><G><D><D><V><I><E><Q><Q><L><A><T><D><Q><M><L><L><H><F><G><N><L><A><M><H><M><N><G><E><L><V><L><R><K><A><R><S><L><L><Y><Q><F><R><L><L><P><R><I><P><C><S><L><H><D><L><C><K><L><C><G><S><G><M><W><D><S><G><S><M><P><A><V><E><C><T><G><H><H><P><G><S><E><S><C><P><Y><G><G><T><V><E><M><P><S><P><K><S><L><R><E><G><K><K><G><P><K><T><P><Q><D><G><F><G><F><R><R> | May act as a GTPase-activating protein for Rab family protein(s).<BOP> | Q8TBP0 |
O95147 | DUS14_HUMAN | Mitogen-activated protein kinase phosphatase 6 | Homo | <M><S><S><R><G><H><S><T><L><P><R><T><L><M><A><P><R><M><I><S><E><G><D><I><G><G><I><A><Q><I><T><S><S><L><F><L><G><R><G><S><V><A><S><N><R><H><L><L><Q><A><R><G><I><T><C><I><V><N><A><T><I><E><I><P><N><F><N><W><P><Q><F><E><Y><V><K><V><P><L><A><D><M><P><H><A><P><I><G><L><Y><F><D><T><V><A><D><K><I><H><S><V><S><R><K><H><G><A><T><L><V><H><C><A><A><G><V><S><R><S><A><T><L><C><I><A><Y><L><M><K><F><H><N><V><C><L><L><E><A><Y><N><W><V><K><A><R><R><P><V><I><R><P><N><V><G><F><W><R><Q><L><I><D><Y><E><R><Q><L><F><G><K><S><T><V><K><M><V><Q><T><P><Y><G><I><V><P><D><V><Y><E><K><E><S><R><H><L><M><P><Y><W><G><I> | Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.<BOP> | O95147 |
P08397 | HEM3_HUMAN | Pre-uroporphyrinogen synthase | Homo | <M><S><G><N><G><N><A><A><A><T><A><E><E><N><S><P><K><M><R><V><I><R><V><G><T><R><K><S><Q><L><A><R><I><Q><T><D><S><V><V><A><T><L><K><A><S><Y><P><G><L><Q><F><E><I><I><A><M><S><T><T><G><D><K><I><L><D><T><A><L><S><K><I><G><E><K><S><L><F><T><K><E><L><E><H><A><L><E><K><N><E><V><D><L><V><V><H><S><L><K><D><L><P><T><V><L><P><P><G><F><T><I><G><A><I><C><K><R><E><N><P><H><D><A><V><V><F><H><P><K><F><V><G><K><T><L><E><T><L><P><E><K><S><V><V><G><T><S><S><L><R><R><A><A><Q><L><Q><R><K><F><P><H><L><E><F><R><S><I><R><G><N><L><N><T><R><L><R><K><L><D><E><Q><Q><E><F><S><A><I><I><L><A><T><A><G><L><Q><R><M><G><W><H><N><R><V><G><Q><I><L><H><P><E><E><C><M><Y><A><V><G><Q><G><A><L><G><V><E><V><R><A><K><D><Q><D><I><L><D><L><V><G><V><L><H><D><P><E><T><L><L><R><C><I><A><E><R><A><F><L><R><H><L><E><G><G><C><S><V><P><V><A><V><H><T><A><M><K><D><G><Q><L><Y><L><T><G><G><V><W><S><L><D><G><S><D><S><I><Q><E><T><M><Q><A><T><I><H><V><P><A><Q><H><E><D><G><P><E><D><D><P><Q><L><V><G><I><T><A><R><N><I><P><R><G><P><Q><L><A><A><Q><N><L><G><I><S><L><A><N><L><L><L><S><K><G><A><K><N><I><L><D><V><A><R><Q><L><N><D><A><H> | As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen . Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact .<BOP> | P08397 |
A6NCV1 | O6C74_HUMAN | Olfactory receptor 6C74 | Homo | <M><R><N><H><T><T><V><A><N><F><I><L><L><G><L><T><D><D><P><Q><L><Q><V><I><I><F><L><L><L><F><F><T><Y><M><L><S><I><T><G><N><L><T><I><I><T><L><T><L><L><D><L><H><L><K><T><P><M><Y><F><F><L><R><N><F><S><F><L><E><V><S><F><T><T><V><Y><I><P><K><F><L><V><S><M><A><T><G><D><K><T><I><S><Y><N><D><C><A><A><Q><L><F><F><T><I><L><L><G><A><T><E><F><F><L><L><A><A><M><S><Y><E><R><Y><V><A><I><C><K><P><L><H><Y><T><T><I><M><S><S><R><V><C><S><L><L><V><F><A><S><W><M><A><G><F><L><I><I><F><P><P><L><L><M><G><L><Q><L><D><F><C><A><A><N><T><V><D><H><F><F><C><D><V><S><P><I><L><Q><L><S><C><T><D><T><D><I><I><E><L><M><M><L><L><S><A><I><L><T><L><L><V><T><L><V><L><V><I><L><S><Y><T><N><I><I><R><T><I><L><K><I><P><S><S><Q><Q><R><K><K><A><F><S><T><C><S><S><H><M><V><V><V><S><I><S><Y><G><S><C><I><F><M><Y><V><K><P><S><A><K><E><R><V><S><L><N><K><G><I><A><L><L><S><T><S><V><A><P><M><L><N><P><F><I><Y><T><L><R><N><K><Q><V><K><D><V><F><K><H><T><V><K><K><I><E><L><F><S><M><K> | Odorant receptor.<BOP> | A6NCV1 |
P87889 | GAK10_HUMAN | HERV-K_5q33.3 provirus ancestral Gag polyprotein | Homo | <M><G><Q><T><K><S><K><I><K><S><K><Y><A><S><Y><L><S><F><I><K><I><L><L><K><R><G><G><V><K><V><S><T><K><N><L><I><K><L><F><Q><I><I><E><Q><F><C><P><W><F><P><E><Q><G><T><S><D><L><K><D><W><K><R><I><G><K><E><L><K><Q><A><G><R><K><G><N><I><I><P><L><T><V><W><N><D><W><A><I><I><K><A><A><L><E><P><F><Q><T><E><E><D><S><I><S><V><S><D><A><P><G><S><C><L><I><D><C><N><E><N><T><R><K><K><S><Q><K><E><T><E><S><L><H><C><E><Y><V><A><E><P><V><M><A><Q><S><T><Q><N><V><D><Y><N><Q><L><Q><E><V><I><Y><P><E><T><L><K><L><E><G><K><G><P><E><L><M><G><P><S><E><S><K><P><R><G><T><S><P><L><P><A><G><Q><V><L><V><R><L><Q><P><Q><K><Q><V><K><E><N><K><T><Q><P><Q><V><A><Y><Q><Y><W><P><L><A><E><L><Q><Y><R><P><P><P><E><S><Q><Y><G><Y><P><G><M><P><P><A><P><Q><G><R><A><P><Y><H><Q><P><P><T><R><R><L><N><P><M><A><P><P><S><R><Q><G><S><E><L><H><E><I><I><D><K><S><R><K><E><G><D><T><E><A><W><Q><F><P><V><T><L><E><P><M><P><P><G><E><G><A><Q><E><G><E><P><P><T><V><E><A><R><Y><K><S><F><S><I><K><M><L><K><D><M><K><E><G><V><K><Q><Y><G><P><N><S><P><Y><M><R><T><L><L><D><S><I><A><Y><G><H><R><L><I><P><Y><D><W><E><I><L><A><K><S><S><L><S><P><S><Q><F><L><Q><F><K><T><W><W><I><D><G><V><Q><E><Q><V><R><R><N><R><A><A><N><P><P><V><N><I><D><A><D><Q><L><L><G><I><G><Q><N><W><S><T><I><S><Q><Q><A><L><M><Q><N><E><A><I><E><Q><V><R><A><I><C><L><R><A><W><E><K><I><Q><D><P><G><S><T><C><P><S><F><N><T><V><R><Q><G><S><K><E><P><Y><P><D><F><V><A><R><L><Q><D><V><A><Q><K><S><I><A><D><E><K><A><G><K><V><I><V><E><L><M><A><Y><E><N><A><N><P><E><C><Q><S><A><I><K><P><L><K><G><K><V><P><A><G><S><D><V><I><S><E><Y><V><K><A><C><D><G><I><G><G><A><M><H><K><A><M><L><M><A><Q><A><I><T><G><V><V><L><G><G><Q><V><R><T><F><G><G><K><C><Y><N><C><G><Q><I><G><H><L><K><K><N><C><P><V><L><N><K><Q><N><I><T><I><Q><A><T><T><T><G><R><E><P><P><D><L><C><P><R><C><K><K><G><K><H><W><A><S><Q><C><R><S><K><F><D><K><N><G><Q><P><L><S><G><N><E><Q><R><G><Q><P><Q><A><P><Q><Q><T><G><A><F><P><I><Q><P><F><V><P><Q><G><F><Q><G><Q><Q><P><P><L><S><Q><V><F><Q><G><I><S><Q><L><P><Q><Y><N><N><C><P><S><P><Q><A><A><V><Q><Q> | The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.<BOP> | P87889 |
Q7RTS5 | OTOP3_HUMAN | Otopetrin-3 | Homo | <M><G><R><G><A><R><A><A><A><A><Q><S><R><W><G><R><A><S><R><A><S><V><S><P><G><R><T><I><R><S><A><P><A><V><G><E><A><Q><E><T><E><A><A><P><E><K><E><N><R><V><D><V><G><A><E><E><R><A><A><A><T><R><P><R><Q><K><S><W><L><V><R><H><F><S><L><L><L><R><R><D><R><Q><A><Q><K><A><G><Q><L><F><S><G><L><L><A><L><N><V><V><F><L><G><G><A><F><I><C><S><M><I><F><N><K><V><A><V><T><L><G><D><V><W><I><L><L><A><T><L><K><V><L><S><L><L><W><L><L><Y><Y><V><A><S><T><T><R><R><P><H><A><V><L><Y><Q><D><P><H><A><G><P><L><W><V><R><G><S><L><V><L><F><G><S><C><T><F><C><L><N><I><F><R><V><G><Y><D><V><S><H><I><R><C><K><S><Q><L><D><L><V><F><S><V><I><E><M><V><F><I><G><V><Q><T><W><V><L><W><K><H><C><K><D><C><V><R><V><Q><T><N><F><T><R><C><G><L><M><L><T><L><A><T><N><L><L><L><W><V><L><A><V><T><N><D><S><M><H><R><E><I><E><A><E><L><G><I><L><M><E><K><S><T><G><N><E><T><N><T><C><L><C><L><N><A><T><A><C><E><A><F><R><R><G><F><L><M><L><Y><P><F><S><T><E><Y><C><L><I><C><C><A><V><L><F><V><M><W><K><N><V><G><R><H><V><A><P><H><M><G><A><H><P><A><T><A><P><F><H><L><H><G><A><I><F><G><P><L><L><G><L><L><V><L><L><A><G><V><C><V><F><V><L><F><Q><I><E><A><S><G><P><A><I><A><C><Q><Y><F><T><L><Y><Y><A><F><Y><V><A><V><L><P><T><M><S><L><A><C><L><A><G><T><A><I><H><G><L><E><E><R><E><L><D><T><V><K><N><P><T><R><S><L><D><V><V><L><L><M><G><A><A><L><G><Q><M><G><I><A><Y><F><S><I><V><A><I><V><A><K><R><P><H><E><L><L><N><R><L><I><L><A><Y><S><L><L><L><I><L><Q><H><I><A><Q><N><L><F><I><I><E><G><L><H><R><R><P><L><W><E><T><V><P><E><G><L><A><G><K><Q><E><A><E><P><P><R><R><G><S><L><L><E><L><G><Q><G><L><Q><R><A><S><L><A><Y><I><H><S><Y><S><H><L><N><W><K><R><R><A><L><K><E><I><S><L><F><L><I><L><C><N><I><T><L><W><M><M><P><A><F><G><I><H><P><E><F><E><N><G><L><E><K><D><F><Y><G><Y><Q><I><W><F><A><I><V><N><F><G><L><P><L><G><V><F><Y><R><M><H><S><V><G><G><L><V><E><V><Y><L><G><A> | Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.<BOP> | Q7RTS5 |
Q969U7 | PSMG2_HUMAN | Tumor necrosis factor superfamily member 5-induced protein 1 | Homo | <M><F><V><P><C><G><E><S><A><P><D><L><A><G><F><T><L><L><M><P><A><V><S><V><G><N><V><G><Q><L><A><M><D><L><I><I><S><T><L><N><M><S><K><I><G><Y><F><Y><T><D><C><L><V><P><M><V><G><N><N><P><Y><A><T><T><E><G><N><S><T><E><L><S><I><N><A><E><V><Y><S><L><P><S><R><K><L><V><A><L><Q><L><R><S><I><F><I><K><Y><K><S><K><P><F><C><E><K><L><L><S><W><V><K><S><S><G><C><A><R><V><I><V><L><S><S><S><H><S><Y><Q><R><N><D><L><Q><L><R><S><T><P><F><R><Y><L><L><T><P><S><M><Q><K><S><V><Q><N><K><I><K><S><L><N><W><E><E><M><E><K><S><R><C><I><P><E><I><D><D><S><E><F><C><I><R><I><P><G><G><G><I><T><K><T><L><Y><D><E><S><C><S><K><E><I><Q><M><A><V><L><L><K><F><V><S><E><G><D><N><I><P><D><A><L><G><L><V><E><Y><L><N><E><W><L><Q><I><L><K><P><L><S><D><D><P><T><V><S><A><S><R><W><K><I><P><S><S><W><R><L><L><F><G><S><G><L><P><P><A><L><F> | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.<BOP> | Q969U7 |
Q9Y5A9 | YTHD2_HUMAN | Renal carcinoma antigen NY-REN-2 | Homo | <M><S><A><S><S><L><L><E><Q><R><P><K><G><Q><G><N><K><V><Q><N><G><S><V><H><Q><K><D><G><L><N><D><D><D><F><E><P><Y><L><S><P><Q><A><R><P><N><N><A><Y><T><A><M><S><D><S><Y><L><P><S><Y><Y><S><P><S><I><G><F><S><Y><S><L><G><E><A><A><W><S><T><G><G><D><T><A><M><P><Y><L><T><S><Y><G><Q><L><S><N><G><E><P><H><F><L><P><D><A><M><F><G><Q><P><G><A><L><G><S><T><P><F><L><G><Q><H><G><F><N><F><F><P><S><G><I><D><F><S><A><W><G><N><N><S><S><Q><G><Q><S><T><Q><S><S><G><Y><S><S><N><Y><A><Y><A><P><S><S><L><G><G><A><M><I><D><G><Q><S><A><F><A><N><E><T><L><N><K><A><P><G><M><N><T><I><D><Q><G><M><A><A><L><K><L><G><S><T><E><V><A><S><N><V><P><K><V><V><G><S><A><V><G><S><G><S><I><T><S><N><I><V><A><S><N><S><L><P><P><A><T><I><A><P><P><K><P><A><S><W><A><D><I><A><S><K><P><A><K><Q><Q><P><K><L><K><T><K><N><G><I><A><G><S><S><L><P><P><P><P><I><K><H><N><M><D><I><G><T><W><D><N><K><G><P><V><A><K><A><P><S><Q><A><L><V><Q><N><I><G><Q><P><T><Q><G><S><P><Q><P><V><G><Q><Q><A><N><N><S><P><P><V><A><Q><A><S><V><G><Q><Q><T><Q><P><L><P><P><P><P><P><Q><P><A><Q><L><S><V><Q><Q><Q><A><A><Q><P><T><R><W><V><A><P><R><N><R><G><S><G><F><G><H><N><G><V><D><G><N><G><V><G><Q><S><Q><A><G><S><G><S><T><P><S><E><P><H><P><V><L><E><K><L><R><S><I><N><N><Y><N><P><K><D><F><D><W><N><L><K><H><G><R><V><F><I><I><K><S><Y><S><E><D><D><I><H><R><S><I><K><Y><N><I><W><C><S><T><E><H><G><N><K><R><L><D><A><A><Y><R><S><M><N><G><K><G><P><V><Y><L><L><F><S><V><N><G><S><G><H><F><C><G><V><A><E><M><K><S><A><V><D><Y><N><T><C><A><G><V><W><S><Q><D><K><W><K><G><R><F><D><V><R><W><I><F><V><K><D><V><P><N><S><Q><L><R><H><I><R><L><E><N><N><E><N><K><P><V><T><N><S><R><D><T><Q><E><V><P><L><E><K><A><K><Q><V><L><K><I><I><A><S><Y><K><H><T><T><S><I><F><D><D><F><S><H><Y><E><K><R><Q><E><E><E><E><S><V><K><K><E><R><Q><G><R><G><K> | (Microbial infection) Promotes viral gene expression and virion production of kaposis sarcoma-associated herpesvirus (KSHV) at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16 cells) . Acts by binding to N6-methyladenosine (m6A)-containing viral RNAs .<BOP> | Q9Y5A9 |
Q92949 | FOXJ1_HUMAN | Hepatocyte nuclear factor 3 forkhead homolog 4 | Homo | <M><A><E><S><W><L><R><L><S><G><A><G><P><A><E><E><A><G><P><E><G><G><L><E><E><P><D><A><L><D><D><S><L><T><S><L><Q><W><L><Q><E><F><S><I><L><N><A><K><A><P><A><L><P><P><G><G><T><D><P><H><G><Y><H><Q><V><P><G><S><A><A><P><G><S><P><L><A><A><D><P><A><C><L><G><Q><P><H><T><P><G><K><P><T><S><S><C><T><S><R><S><A><P><P><G><L><Q><A><P><P><P><D><D><V><D><Y><A><T><N><P><H><V><K><P><P><Y><S><Y><A><T><L><I><C><M><A><M><Q><A><S><K><A><T><K><I><T><L><S><A><I><Y><K><W><I><T><D><N><F><C><Y><F><R><H><A><D><P><T><W><Q><N><S><I><R><H><N><L><S><L><N><K><C><F><I><K><V><P><R><E><K><D><E><P><G><K><G><G><F><W><R><I><D><P><Q><Y><A><E><R><L><L><S><G><A><F><K><K><R><R><L><P><P><V><H><I><H><P><A><F><A><R><Q><A><A><Q><E><P><S><A><V><P><R><A><G><P><L><T><V><N><T><E><A><Q><Q><L><L><R><E><F><E><E><A><T><G><E><A><G><W><G><A><G><E><G><R><L><G><H><K><R><K><Q><P><L><P><K><R><V><A><K><V><P><R><P><P><S><T><L><L><P><T><P><E><E><Q><G><E><L><E><P><L><K><G><N><F><D><W><E><A><I><F><D><A><G><T><L><G><G><E><L><G><A><L><E><A><L><E><L><S><P><P><L><S><P><A><S><H><V><D><V><D><L><T><I><H><G><R><H><I><D><C><P><A><T><W><G><P><S><V><E><Q><A><A><D><S><L><D><F><D><E><T><F><L><A><T><S><F><L><Q><H><P><W><D><E><S><G><S><G><C><L><P><P><E><P><L><F><E><A><G><D><A><T><L><A><S><D><L><Q><D><W><A><S><V><G><A><F><L> | Transcription factor specifically required for the formation of motile cilia . Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.<BOP> | Q92949 |
Q9UP38 | FZD1_HUMAN | FzE1 | null | <M><A><E><E><E><A><P><K><K><S><R><A><A><G><G><G><A><S><W><E><L><C><A><G><A><L><S><A><R><L><A><E><E><G><S><G><D><A><G><G><R><R><R><P><P><V><D><P><R><R><L><A><R><Q><L><L><L><L><L><W><L><L><E><A><P><L><L><L><G><V><R><A><Q><A><A><G><Q><G><P><G><Q><G><P><G><P><G><Q><Q><P><P><P><P><P><Q><Q><Q><Q><S><G><Q><Q><Y><N><G><E><R><G><I><S><V><P><D><H><G><Y><C><Q><P><I><S><I><P><L><C><T><D><I><A><Y><N><Q><T><I><M><P><N><L><L><G><H><T><N><Q><E><D><A><G><L><E><V><H><Q><F><Y><P><L><V><K><V><Q><C><S><A><E><L><K><F><F><L><C><S><M><Y><A><P><V><C><T><V><L><E><Q><A><L><P><P><C><R><S><L><C><E><R><A><R><Q><G><C><E><A><L><M><N><K><F><G><F><Q><W><P><D><T><L><K><C><E><K><F><P><V><H><G><A><G><E><L><C><V><G><Q><N><T><S><D><K><G><T><P><T><P><S><L><L><P><E><F><W><T><S><N><P><Q><H><G><G><G><G><H><R><G><G><F><P><G><G><A><G><A><S><E><R><G><K><F><S><C><P><R><A><L><K><V><P><S><Y><L><N><Y><H><F><L><G><E><K><D><C><G><A><P><C><E><P><T><K><V><Y><G><L><M><Y><F><G><P><E><E><L><R><F><S><R><T><W><I><G><I><W><S><V><L><C><C><A><S><T><L><F><T><V><L><T><Y><L><V><D><M><R><R><F><S><Y><P><E><R><P><I><I><F><L><S><G><C><Y><T><A><V><A><V><A><Y><I><A><G><F><L><L><E><D><R><V><V><C><N><D><K><F><A><E><D><G><A><R><T><V><A><Q><G><T><K><K><E><G><C><T><I><L><F><M><M><L><Y><F><F><S><M><A><S><S><I><W><W><V><I><L><S><L><T><W><F><L><A><A><G><M><K><W><G><H><E><A><I><E><A><N><S><Q><Y><F><H><L><A><A><W><A><V><P><A><I><K><T><I><T><I><L><A><L><G><Q><V><D><G><D><V><L><S><G><V><C><F><V><G><L><N><N><V><D><A><L><R><G><F><V><L><A><P><L><F><V><Y><L><F><I><G><T><S><F><L><L><A><G><F><V><S><L><F><R><I><R><T><I><M><K><H><D><G><T><K><T><E><K><L><E><K><L><M><V><R><I><G><V><F><S><V><L><Y><T><V><P><A><T><I><V><I><A><C><Y><F><Y><E><Q><A><F><R><D><Q><W><E><R><S><W><V><A><Q><S><C><K><S><Y><A><I><P><C><P><H><L><Q><A><G><G><G><A><P><P><H><P><P><M><S><P><D><F><T><V><F><M><I><K><Y><L><M><T><L><I><V><G><I><T><S><G><F><W><I><W><S><G><K><T><L><N><S><W><R><K><F><Y><T><R><L><T><N><S><K><Q><G><E><T><T><V> | (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.<BOP> | Q9UP38 |
A2VDF0 | FUCM_HUMAN | Fucose mutarotase | Homo | <M><V><A><L><K><G><V><P><A><L><L><S><P><E><L><L><Y><A><L><A><R><M><G><H><G><D><E><I><V><L><A><D><L><N><F><P><A><S><S><I><C><Q><C><G><P><M><E><I><R><A><D><G><L><G><I><P><Q><L><L><E><A><V><L><K><L><L><P><L><D><T><Y><V><E><S><P><A><A><V><M><E><L><V><P><S><D><K><E><R><G><L><Q><T><P><V><W><T><E><Y><E><S><I><L><R><R><A><G><C><V><R><A><L><A><K><I><E><R><F><E><F><Y><E><R><A><K><K><A><F><A><V><V><A><T><G><E><T><A><L><Y><G><N><L><I><L><R><K><G><V><L><A><L><N><P><L><L> | Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.<BOP> | A2VDF0 |
Q96RL6 | SIG11_HUMAN | Sialic acid-binding Ig-like lectin 11 | Homo | <M><V><P><G><Q><A><Q><P><Q><S><P><E><M><L><L><L><P><L><L><L><P><V><L><G><A><G><S><L><N><K><D><P><S><Y><S><L><Q><V><Q><R><Q><V><P><V><P><E><G><L><C><V><I><V><S><C><N><L><S><Y><P><R><D><G><W><D><E><S><T><A><A><Y><G><Y><W><F><K><G><R><T><S><P><K><T><G><A><P><V><A><T><N><N><Q><S><R><E><V><E><M><S><T><R><D><R><F><Q><L><T><G><D><P><G><K><G><S><C><S><L><V><I><R><D><A><Q><R><E><D><E><A><W><Y><F><F><R><V><E><R><G><S><R><V><R><H><S><F><L><S><N><A><F><F><L><K><V><T><A><L><T><K><K><P><D><V><Y><I><P><E><T><L><E><P><G><Q><P><V><T><V><I><C><V><F><N><W><A><F><K><K><C><P><A><P><S><F><S><W><T><G><A><A><L><S><P><R><R><T><R><P><S><T><S><H><F><S><V><L><S><F><T><P><S><P><Q><D><H><D><T><D><L><T><C><H><V><D><F><S><R><K><G><V><S><A><Q><R><T><V><R><L><R><V><A><Y><A><P><K><D><L><I><I><S><I><S><H><D><N><T><S><A><L><E><L><Q><G><N><V><I><Y><L><E><V><Q><K><G><Q><F><L><R><L><L><C><A><A><D><S><Q><P><P><A><T><L><S><W><V><L><Q><D><R><V><L><S><S><S><H><P><W><G><P><R><T><L><G><L><E><L><R><G><V><R><A><G><D><S><G><R><Y><T><C><R><A><E><N><R><L><G><S><Q><Q><Q><A><L><D><L><S><V><Q><Y><P><P><E><N><L><R><V><M><V><S><Q><A><N><R><T><V><L><E><N><L><G><N><G><T><S><L><P><V><L><E><G><Q><S><L><R><L><V><C><V><T><H><S><S><P><P><A><R><L><S><W><T><R><W><G><Q><T><V><G><P><S><Q><P><S><D><P><G><V><L><E><L><P><P><I><Q><M><E><H><E><G><E><F><T><C><H><A><Q><H><P><L><G><S><Q><H><V><S><L><S><L><S><V><H><Y><P><P><Q><L><L><G><P><S><C><S><W><E><A><E><G><L><H><C><S><C><S><S><Q><A><S><P><A><P><S><L><R><W><W><L><G><E><E><L><L><E><G><N><S><S><Q><G><S><F><E><V><T><P><S><S><A><G><P><W><A><N><S><S><L><S><L><H><G><G><L><S><S><G><L><R><L><R><C><K><A><W><N><V><H><G><A><Q><S><G><S><V><F><Q><L><L><P><G><K><L><E><H><G><G><G><L><G><L><G><A><A><L><G><A><G><V><A><A><L><L><A><F><C><S><C><L><V><V><F><R><V><K><I><C><R><K><E><A><R><K><R><A><A><A><E><Q><D><V><P><S><T><L><G><P><I><S><Q><G><H><Q><H><E><C><S><A><G><S><S><Q><D><H><P><P><P><G><A><A><T><Y><T><P><G><K><G><E><E><Q><E><L><H><Y><A><S><L><S><F><Q><G><L><R><L><W><E><P><A><D><Q><E><A><P><S><T><T><E><Y><S><E><I><K><I><H><T><G><Q><P><L><R><G><P><G><F><G><L><Q><L><E><R><E><M><S><G><M><V><P><K> | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.<BOP> | Q96RL6 |
Q5BKZ1 | ZN326_HUMAN | Zinc finger protein interacting with mRNPs and DBC1 | Homo | <M><D><F><E><D><D><Y><T><H><S><A><C><R><N><T><Y><Q><G><F><N><G><M><D><R><D><Y><G><P><G><S><Y><G><G><M><D><R><D><Y><G><H><G><S><Y><G><G><Q><R><S><M><D><S><Y><L><N><Q><S><Y><G><M><D><N><H><S><G><G><G><G><G><S><R><F><G><P><Y><E><S><Y><D><S><R><S><S><L><G><G><R><D><L><Y><R><S><G><Y><G><F><N><E><P><E><Q><S><R><F><G><G><S><Y><G><G><R><F><E><S><S><Y><R><N><S><L><D><S><F><G><G><R><N><Q><G><G><S><S><W><E><A><P><Y><S><R><S><K><L><R><P><G><F><M><E><D><R><G><R><E><N><Y><S><S><Y><S><S><F><S><S><P><H><M><K><P><A><P><V><G><S><R><G><R><G><T><P><A><Y><P><E><S><T><F><G><S><R><N><Y><D><A><F><G><G><P><S><T><G><R><G><R><G><R><G><H><M><G><D><F><G><S><I><H><R><P><G><I><V><V><D><Y><Q><N><K><S><T><N><V><T><V><A><A><A><R><G><I><K><R><K><M><M><Q><P><F><N><K><P><S><G><T><F><I><K><K><P><K><L><A><K><P><M><E><K><I><S><L><S><K><S><P><T><K><T><D><P><K><N><E><E><E><E><K><R><R><I><E><A><R><R><E><K><Q><R><R><R><R><E><K><N><S><E><K><Y><G><D><G><Y><R><M><A><F><T><C><S><F><C><K><F><R><T><F><E><E><K><D><I><E><L><H><L><E><S><S><S><H><Q><E><T><L><D><H><I><Q><K><Q><T><K><F><D><K><V><V><M><E><F><L><H><E><C><M><V><N><K><F><K><K><T><S><I><R><K><Q><Q><T><N><N><Q><T><E><V><V><K><I><I><E><K><D><V><M><E><G><V><T><V><D><D><H><M><M><K><V><E><T><V><H><C><S><A><C><S><V><Y><I><P><A><L><H><S><S><V><Q><Q><H><L><K><S><P><D><H><I><K><G><K><Q><A><Y><K><E><Q><I><K><R><E><S><V><L><T><A><T><S><I><L><N><N><P><I><V><K><A><R><Y><E><R><F><V><K><G><E><N><P><F><E><I><Q><D><H><S><Q><D><Q><Q><I><E><G><D><E><E><D><E><E><K><I><D><E><P><I><E><E><E><E><D><E><D><E><E><E><E><A><E><E><V><G><E><V><E><E><V><E><E><V><E><E><V><R><E><G><G><I><E><G><E><G><N><I><Q><G><V><G><E><G><G><E><V><G><V><V><G><E><V><E><G><V><G><E><V><E><E><V><E><E><L><E><E><E><T><A><K><E><E><P><A><D><F><P><V><E><Q><P><E><E><N> | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.<BOP> | Q5BKZ1 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.