accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
P01743 | HV146_HUMAN | Ig heavy chain V-I region Mot | Homo | <M><D><W><T><W><R><V><F><C><L><L><A><V><A><P><G><A><H><S><Q><V><Q><L><V><Q><S><G><A><E><V><K><K><P><G><A><S><V><K><V><S><C><K><A><S><G><Y><T><F><T><S><Y><Y><M><H><W><V><R><Q><A><P><G><Q><G><L><E><W><M><G><I><I><N><P><S><G><G><S><T><S><Y><A><Q><K><F><Q><G><R><V><T><M><T><R><D><T><S><T><S><T><V><Y><M><E><L><S><S><L><R><S><E><D><T><A><V><Y><Y><C><A><R> | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | P01743 |
Q9Y5W3 | KLF2_HUMAN | Lung krueppel-like factor | Homo | <M><A><L><S><E><P><I><L><P><S><F><S><T><F><A><S><P><C><R><E><R><G><L><Q><E><R><W><P><R><A><E><P><E><S><G><G><T><D><D><D><L><N><S><V><L><D><F><I><L><S><M><G><L><D><G><L><G><A><E><A><A><P><E><P><P><P><P><P><P><P><P><A><F><Y><Y><P><E><P><G><A><P><P><P><Y><S><A><P><A><G><G><L><V><S><E><L><L><R><P><E><L><D><A><P><L><G><P><A><L><H><G><R><F><L><L><A><P><P><G><R><L><V><K><A><E><P><P><E><A><D><G><G><G><G><Y><G><C><A><P><G><L><T><R><G><P><R><G><L><K><R><E><G><A><P><G><P><A><A><S><C><M><R><G><P><G><G><R><P><P><P><P><P><D><T><P><P><L><S><P><D><G><P><A><R><L><P><A><P><G><P><R><A><S><F><P><P><P><F><G><G><P><G><F><G><A><P><G><P><G><L><H><Y><A><P><P><A><P><P><A><F><G><L><F><D><D><A><A><A><A><A><A><A><L><G><L><A><P><P><A><A><R><G><L><L><T><P><P><A><S><P><L><E><L><L><E><A><K><P><K><R><G><R><R><S><W><P><R><K><R><T><A><T><H><T><C><S><Y><A><G><C><G><K><T><Y><T><K><S><S><H><L><K><A><H><L><R><T><H><T><G><E><K><P><Y><H><C><N><W><D><G><C><G><W><K><F><A><R><S><D><E><L><T><R><H><Y><R><K><H><T><G><H><R><P><F><Q><C><H><L><C><D><R><A><F><S><R><S><D><H><L><A><L><H><M><K><R><H><M> | Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription . Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements .<BOP> | Q9Y5W3 |
Q15935 | ZNF77_HUMAN | ZNFpT1 | Homo | <M><D><C><V><I><F><E><E><V><A><V><N><F><T><P><E><E><W><A><L><L><D><H><A><Q><R><S><L><Y><R><D><V><M><L><E><T><C><R><N><L><A><S><L><D><C><Y><I><Y><V><R><T><S><G><S><S><S><Q><R><D><V><F><G><N><G><I><S><N><D><E><E><I><V><K><F><T><G><S><D><S><W><S><I><F><G><E><N><W><R><F><D><N><T><G><D><Q><H><Q><I><P><Q><R><H><L><R><S><Q><L><G><R><L><C><E><S><N><E><G><H><Q><C><G><E><T><L><S><Q><T><A><N><L><L><V><H><K><S><Y><P><T><E><A><K><P><S><E><C><T><K><C><G><K><A><F><E><N><R><Q><R><S><H><T><G><Q><R><P><C><K><E><C><G><Q><A><C><S><C><L><S><C><Q><S><P><P><M><K><T><Q><T><V><E><K><P><C><N><C><Q><D><S><R><T><A><S><V><T><Y><V><K><S><L><S><S><K><K><S><Y><E><C><Q><K><C><G><K><A><F><I><C><P><S><S><F><R><G><H><V><N><S><H><H><G><Q><K><T><H><A><C><K><V><C><G><K><T><F><M><Y><Y><S><Y><L><T><R><H><V><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><C><P><S><Y><F><R><E><H><V><R><T><H><T><G><E><K><P><Y><E><C><K><H><C><G><K><S><F><S><C><Y><S><S><F><R><D><H><V><R><T><H><T><G><E><K><P><C><Q><C><K><H><C><G><K><A><F><T><C><Y><S><S><L><R><E><H><G><R><T><H><S><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><Y><P><S><S><L><R><A><H><M><R><M><H><T><G><E><K><P><Y><V><C><K><Q><C><G><K><A><F><G><C><P><T><Y><F><R><R><H><V><K><T><H><S><G><V><K><P><Y><Q><C><K><E><C><G><K><A><Y><S><F><S><S><S><L><R><I><H><V><R><T><H><T><G><E><K><P><F><E><C><K><H><C><G><K><A><F><S><C><H><S><S><L><R><E><H><V><R><T><H><S><G><E><K><P><Y><E><C><N><Q><C><G><K><A><F><S><H><A><Q><Y><F><Q><K><H><V><R><S><H><S><G><V><K><P><Y><E><C><T><E><C><G><K><A><Y><S><C><S><S><S><L><R><V><H><V><R><T><H><T><G><E><R><P><Y><E><C><K><Q><C><G><K><T><F><R><Y><L><A><S><L><Q><A><H><V><R><T><H><A><G><A> | May be involved in transcriptional regulation.<BOP> | Q15935 |
Q9Y6Y9 | LY96_HUMAN | Protein MD-2 | Homo | <M><L><P><F><L><F><F><S><T><L><F><S><S><I><F><T><E><A><Q><K><Q><Y><W><V><C><N><S><S><D><A><S><I><S><Y><T><Y><C><D><K><M><Q><Y><P><I><S><I><N><V><N><P><C><I><E><L><K><R><S><K><G><L><L><H><I><F><Y><I><P><R><R><D><L><K><Q><L><Y><F><N><L><Y><I><T><V><N><T><M><N><L><P><K><R><K><E><V><I><C><R><G><S><D><D><D><Y><S><F><C><R><A><L><K><G><E><T><V><N><T><T><I><S><F><S><F><K><G><I><K><F><S><K><G><K><Y><K><C><V><V><E><A><I><S><G><S><P><E><E><M><L><F><C><L><E><F><V><I><L><H><Q><P><N><S><N> | Binds bacterial lipopolysaccharide (LPS) . Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria . Enhances TLR4-dependent activation of NF-kappa-B . Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS .<BOP> | Q9Y6Y9 |
A0A075B6K6 | LV403_HUMAN | Immunoglobulin lambda variable 4-3 | Homo | <M><A><W><V><S><F><Y><L><L><P><F><I><F><S><T><G><L><C><A><L><P><V><L><T><Q><P><P><S><A><S><A><L><L><G><A><S><I><K><L><T><C><T><L><S><S><E><H><S><T><Y><T><I><E><W><Y><Q><Q><R><P><G><R><S><P><Q><Y><I><M><K><V><K><S><D><G><S><H><S><K><G><D><G><I><P><D><R><F><M><G><S><S><S><G><A><D><R><Y><L><T><F><S><N><L><Q><S><D><D><E><A><E><Y><H><C><G><E><S><H><T><I><D><G><Q><V><G> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A075B6K6 |
O60814 | H2B1K_HUMAN | HIRA-interacting protein 1 | Homo | <M><P><E><P><A><K><S><A><P><A><P><K><K><G><S><K><K><A><V><T><K><A><Q><K><K><D><G><K><K><R><K><R><S><R><K><E><S><Y><S><V><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><G><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><E><I><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><A><K> | Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<BOP> | O60814 |
O00515 | LAD1_HUMAN | Linear IgA disease antigen | Homo | <M><A><V><S><R><K><D><W><S><A><L><S><S><L><A><R><Q><R><T><L><E><D><E><E><E><Q><E><R><E><R><R><R><R><H><R><N><L><S><S><T><T><D><D><E><A><P><R><L><S><Q><N><G><D><R><Q><A><S><A><S><E><R><L><P><S><V><E><E><A><E><V><P><K><P><L><P><P><A><S><K><D><E><D><E><D><I><Q><S><I><L><R><T><R><Q><E><R><R><Q><R><R><Q><V><V><E><A><A><Q><A><P><I><Q><E><R><L><E><A><E><E><G><R><N><S><L><S><P><V><Q><A><T><Q><K><P><L><V><S><K><K><E><L><E><I><P><P><R><R><R><L><S><R><E><Q><R><G><P><W><A><L><E><E><E><S><L><V><G><R><E><P><E><E><R><K><K><G><V><P><E><K><S><P><V><L><E><K><S><S><M><P><K><K><T><A><P><E><K><S><L><V><S><D><K><T><S><I><S><E><K><V><L><A><S><E><K><T><S><L><S><E><K><I><A><V><S><E><K><R><N><S><S><E><K><K><S><V><L><E><K><T><S><V><S><E><K><S><L><A><P><G><M><A><L><G><S><G><R><R><L><V><S><E><K><A><S><I><F><E><K><A><L><A><S><E><K><S><P><T><A><D><A><K><P><A><P><K><R><A><T><A><S><E><Q><P><L><A><Q><E><P><P><A><S><G><G><S><P><A><T><T><K><E><Q><R><G><R><A><L><P><G><K><N><L><P><S><L><A><K><Q><G><A><S><D><P><P><T><V><A><S><R><L><P><P><V><T><L><Q><V><K><I><P><S><K><E><E><E><A><D><M><S><S><P><T><Q><R><T><Y><S><S><S><L><K><R><S><S><P><R><T><I><S><F><R><M><K><P><K><K><E><N><S><E><T><T><L><T><R><S><A><S><M><K><L><P><D><N><T><V><K><L><G><E><K><L><E><R><Y><H><T><A><I><R><R><S><E><S><V><K><S><R><G><L><P><C><T><E><L><F><V><A><P><V><G><V><A><S><K><R><H><L><F><E><K><E><L><A><G><Q><S><R><A><E><P><A><S><S><R><K><E><N><L><R><L><S><G><V><V><T><S><R><L><N><L><W><I><S><R><T><Q><E><S><G><D><Q><D><P><Q><E><A><Q><K><A><S><S><A><T><E><R><T><Q><W><G><Q><K><S><D><S><S><L><D><A><E><V> | Anchoring filament protein which is a component of the basement membrane zone.<BOP> | O00515 |
Q86SJ2 | AMGO2_HUMAN | Differentially expressed in gastric adenocarcinomas | Homo | <M><S><L><R><V><H><T><L><P><T><L><L><G><A><V><V><R><P><G><C><R><E><L><L><C><L><L><M><I><T><V><T><V><G><P><G><A><S><G><V><C><P><T><A><C><I><C><A><T><D><I><V><S><C><T><N><K><N><L><S><K><V><P><G><N><L><F><R><L><I><K><R><L><D><L><S><Y><N><R><I><G><L><L><D><S><E><W><I><P><V><S><F><A><K><L><N><T><L><I><L><R><H><N><N><I><T><S><I><S><T><G><S><F><S><T><T><P><N><L><K><C><L><D><L><S><S><N><K><L><K><T><V><K><N><A><V><F><Q><E><L><K><V><L><E><V><L><L><L><Y><N><N><H><I><S><Y><L><D><P><S><A><F><G><G><L><S><Q><L><Q><K><L><Y><L><S><G><N><F><L><T><Q><F><P><M><D><L><Y><V><G><R><F><K><L><A><E><L><M><F><L><D><V><S><Y><N><R><I><P><S><M><P><M><H><H><I><N><L><V><P><G><K><Q><L><R><G><I><Y><L><H><G><N><P><F><V><C><D><C><S><L><Y><S><L><L><V><F><W><Y><R><R><H><F><S><S><V><M><D><F><K><N><D><Y><T><C><R><L><W><S><D><S><R><H><S><R><Q><V><L><L><L><Q><D><S><F><M><N><C><S><D><S><I><I><N><G><S><F><R><A><L><G><F><I><H><E><A><Q><V><G><E><R><L><M><V><H><C><D><S><K><T><G><N><A><N><T><D><F><I><W><V><G><P><D><N><R><L><L><E><P><D><K><E><M><E><N><F><Y><V><F><H><N><G><S><L><V><I><E><S><P><R><F><E><D><A><G><V><Y><S><C><I><A><M><N><K><Q><R><L><L><N><E><T><V><D><V><T><I><N><V><S><N><F><T><V><S><R><S><H><A><H><E><A><F><N><T><A><F><T><T><L><A><A><C><V><A><S><I><V><L><V><L><L><Y><L><Y><L><T><P><C><P><C><K><C><K><T><K><R><Q><K><N><M><L><H><Q><S><N><A><H><S><S><I><L><S><P><G><P><A><S><D><A><S><A><D><E><R><K><A><G><A><G><K><R><V><V><F><L><E><P><L><K><D><T><A><A><G><Q><N><G><K><V><R><L><F><P><S><E><A><V><I><A><E><G><I><L><K><S><T><R><G><K><S><D><S><D><S><V><N><S><V><F><S><D><T><P><F><V><A><S><T> | Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.<BOP> | Q86SJ2 |
Q9NQW7 | XPP1_HUMAN | X-prolyl aminopeptidase 1, soluble | Homo | <M><P><P><K><V><T><S><E><L><L><R><Q><L><R><Q><A><M><R><N><S><E><Y><V><T><E><P><I><Q><A><Y><I><I><P><S><G><D><A><H><Q><S><E><Y><I><A><P><C><D><C><R><R><A><F><V><S><G><F><D><G><S><A><G><T><A><I><I><T><E><E><H><A><A><M><W><T><D><G><R><Y><F><L><Q><A><A><K><Q><M><D><S><N><W><T><L><M><K><M><G><L><K><D><T><P><T><Q><E><D><W><L><V><S><V><L><P><E><G><S><R><V><G><V><D><P><L><I><I><P><T><D><Y><W><K><K><M><A><K><V><L><R><S><A><G><H><H><L><I><P><V><K><E><N><L><V><D><K><I><W><T><D><R><P><E><R><P><C><K><P><L><L><T><L><G><L><D><Y><T><G><I><S><W><K><D><K><V><A><D><L><R><L><K><M><A><E><R><N><V><M><W><F><V><V><T><A><L><D><E><I><A><W><L><F><N><L><R><G><S><D><V><E><H><N><P><V><F><F><S><Y><A><I><I><G><L><E><T><I><M><L><F><I><D><G><D><R><I><D><A><P><S><V><K><E><H><L><L><L><D><L><G><L><E><A><E><Y><R><I><Q><V><H><P><Y><K><S><I><L><S><E><L><K><A><L><C><A><D><L><S><P><R><E><K><V><W><V><S><D><K><A><S><Y><A><V><S><E><T><I><P><K><D><H><R><C><C><M><P><Y><T><P><I><C><I><A><K><A><V><K><N><S><A><E><S><E><G><M><R><R><A><H><I><K><D><A><V><A><L><C><E><L><F><N><W><L><E><K><E><V><P><K><G><G><V><T><E><I><S><A><A><D><K><A><E><E><F><R><R><Q><Q><A><D><F><V><D><L><S><F><P><T><I><S><S><T><G><P><N><G><A><I><I><H><Y><A><P><V><P><E><T><N><R><T><L><S><L><D><E><V><Y><L><I><D><S><G><A><Q><Y><K><D><G><T><T><D><V><T><R><T><M><H><F><G><T><P><T><A><Y><E><K><E><C><F><T><Y><V><L><K><G><H><I><A><V><S><A><A><V><F><P><T><G><T><K><G><H><L><L><D><S><F><A><R><S><A><L><W><D><S><G><L><D><Y><L><H><G><T><G><H><G><V><G><S><F><L><N><V><H><E><G><P><C><G><I><S><Y><K><T><F><S><D><E><P><L><E><A><G><M><I><V><T><D><E><P><G><Y><Y><E><D><G><A><F><G><I><R><I><E><N><V><V><L><V><V><P><V><K><T><K><Y><N><F><N><N><R><G><S><L><T><F><E><P><L><T><L><V><P><I><Q><T><K><M><I><D><V><D><S><L><T><D><K><E><C><D><W><L><N><N><Y><H><L><T><C><R><D><V><I><G><K><E><L><Q><K><Q><G><R><Q><E><A><L><E><W><L><I><R><E><T><Q><P><I><S><K><Q><H> | Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.<BOP> | Q9NQW7 |
A0A5B0 | TVB14_HUMAN | T cell receptor beta variable 14 | Homo | <M><V><S><R><L><L><S><L><V><S><L><C><L><L><G><A><K><H><I><E><A><G><V><T><Q><F><P><S><H><S><V><I><E><K><G><Q><T><V><T><L><R><C><D><P><I><S><G><H><D><N><L><Y><W><Y><R><R><V><M><G><K><E><I><K><F><L><L><H><F><V><K><E><S><K><Q><D><E><S><G><M><P><N><N><R><F><L><A><E><R><T><G><G><T><Y><S><T><L><K><V><Q><P><A><E><L><E><D><S><G><V><Y><F><C><A><S><S><Q> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A5B0 |
Q63HM1 | KFA_HUMAN | N-formylkynurenine formamidase | Homo | <M><M><D><V><S><G><V><G><F><P><S><K><V><P><W><K><K><M><S><A><E><E><L><E><N><Q><Y><C><P><S><R><W><V><V><R><L><G><A><E><E><A><L><R><T><Y><S><Q><I><G><I><E><A><T><T><R><A><R><A><T><R><K><S><L><L><H><V><P><Y><G><D><G><E><G><E><K><V><D><I><Y><F><P><D><E><S><S><E><A><L><P><F><F><L><F><F><H><G><G><Y><W><Q><S><G><S><K><D><E><S><A><F><M><V><H><P><L><T><A><Q><G><V><A><V><V><I><V><A><Y><G><I><A><P><K><G><T><L><D><H><M><V><D><Q><V><T><R><S><V><A><F><V><Q><K><R><Y><P><S><N><K><G><I><Y><L><C><G><H><S><A><G><A><H><L><A><A><M><M><L><L><A><D><W><T><K><H><G><V><T><P><N><L><R><G><F><F><L><V><S><G><V><F><D><L><E><P><I><V><Y><T><S><Q><N><V><A><L><Q><L><T><L><E><D><A><Q><R><N><S><P><Q><L><K><V><A><Q><A><Q><P><V><D><P><T><C><R><V><L><V><V><V><G><Q><F><D><S><P><E><F><H><R><Q><S><W><E><F><Y><Q><T><L><C><Q><G><E><W><K><A><S><F><E><E><L><H><D><V><D><H><F><E><I><V><E><N><L><T><Q><K><D><N><V><L><T><Q><I><I><L><K><T><I><F><Q> | Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.<BOP> | Q63HM1 |
Q969V4 | TEKT1_HUMAN | Tektin-1 | Homo | <M><A><K><L><L><Q><P><P><P><K><F><L><P><S><E><W><H><I><A><N><K><N><Q><Y><H><R><A><D><A><Q><R><S><R><S><E><R><L><V><A><E><S><Q><R><L><V><D><E><I><E><K><T><T><R><K><S><Q><S><D><V><N><K><K><L><E><Q><R><L><E><E><V><Q><F><W><K><K><E><L><D><D><K><L><E><Q><L><V><N><V><T><D><D><L><L><I><Y><K><I><R><L><E><K><A><L><E><T><L><K><E><P><L><H><I><T><E><T><C><L><A><Y><R><E><K><R><I><G><I><D><L><V><H><D><T><V><E><H><E><L><I><K><E><A><E><I><I><Q><G><I><M><A><L><L><T><R><T><L><E><E><A><S><E><Q><I><R><M><N><R><S><A><K><Y><N><L><E><K><D><L><K><D><K><F><V><A><L><T><I><D><D><I><C><F><S><L><N><N><N><S><P><N><I><R><Y><S><E><N><A><V><R><I><E><P><N><S><V><S><L><E><D><W><L><D><F><S><S><T><N><V><E><K><A><D><K><Q><R><N><N><S><L><M><L><K><A><L><V><D><R><I><L><S><Q><T><A><N><D><L><R><K><Q><C><D><V><V><D><T><A><F><K><N><G><L><K><D><T><K><D><A><R><D><K><L><A><D><H><L><A><K><V><M><E><E><I><A><S><Q><E><K><N><I><T><A><L><E><K><A><I><L><D><Q><E><G><P><A><K><V><A><H><T><R><L><E><T><R><T><H><R><P><N><V><E><L><C><R><D><V><A><Q><Y><R><L><M><K><E><V><Q><E><I><T><H><N><V><A><R><L><K><E><T><L><A><Q><A><Q><A><E><L><K><G><L><H><R><R><Q><L><A><L><Q><E><E><I><Q><V><K><E><N><T><I><Y><I><D><E><V><L><C><M><Q><M><R><K><S><I><P><L><R><D><G><E><D><H><G><V><W><A><G><G><L><R><P><D><A><V><C> | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.<BOP> | Q969V4 |
Q9NZC4 | EHF_HUMAN | Epithelium-specific Ets transcription factor 3 | Homo | <M><I><L><E><G><G><G><V><M><N><L><N><P><G><N><N><L><L><H><Q><P><P><A><W><T><D><S><Y><S><T><C><N><V><S><S><G><F><F><G><G><Q><W><H><E><I><H><P><Q><Y><W><T><K><Y><Q><V><W><E><W><L><Q><H><L><L><D><T><N><Q><L><D><A><N><C><I><P><F><Q><E><F><D><I><N><G><E><H><L><C><S><M><S><L><Q><E><F><T><R><A><A><G><T><A><G><Q><L><L><Y><S><N><L><Q><H><L><K><W><N><G><Q><C><S><S><D><L><F><Q><S><T><H><N><V><I><V><K><T><E><Q><T><E><P><S><I><M><N><T><W><K><D><E><N><Y><L><Y><D><T><N><Y><G><S><T><V><D><L><L><D><S><K><T><F><C><R><A><Q><I><S><M><T><T><T><S><H><L><P><V><A><E><S><P><D><M><K><K><E><Q><D><P><P><A><K><C><H><T><K><K><H><N><P><R><G><T><H><L><W><E><F><I><R><D><I><L><L><N><P><D><K><N><P><G><L><I><K><W><E><D><R><S><E><G><V><F><R><F><L><K><S><E><A><V><A><Q><L><W><G><K><K><K><N><N><S><S><M><T><Y><E><K><L><S><R><A><M><R><Y><Y><Y><K><R><E><I><L><E><R><V><D><G><R><R><L><V><Y><K><F><G><K><N><A><R><G><W><R><E><N><E><N> | Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.<BOP> | Q9NZC4 |
Q9Y284 | ASTER_HUMAN | WDR83 opposite strand | Homo | <M><S><T><N><N><M><S><D><P><R><R><P><N><K><V><L><R><Y><K><P><P><P><S><E><C><N><P><A><L><D><D><P><T><P><D><Y><M><N><L><L><G><M><I><F><S><M><C><G><L><M><L><K><L><K><W><C><A><W><V><A><V><Y><C><S><F><I><S><F><A><N><S><R><S><S><E><D><T><K><Q><M><M><S><S><F><M><L><S><I><S><A><V><V><M><S><Y><L><Q><N><P><Q><P><M><T><P><P><W> | Component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes . The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins . WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix . WDR83OS/Asterix associates with the first transmembrane domain (TMD1) of the nascent chain, independently of the N-glycosylation of the chain and irrespective of the amino acid sequence and transmembrane topology of TMD1 . The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which TMD1 binds .<BOP> | Q9Y284 |
Q969E4 | TCAL3_HUMAN | Transcription elongation factor S-II protein-like 3 | Homo | <M><E><K><P><Y><N><K><N><E><G><N><L><E><N><E><G><K><P><E><D><E><V><E><P><D><D><E><G><K><S><D><E><E><E><K><P><D><V><E><G><K><T><E><C><E><G><K><R><E><D><E><G><E><P><G><D><E><G><Q><L><E><D><E><G><S><Q><E><K><Q><G><R><S><E><G><E><G><K><P><Q><G><E><G><K><P><A><S><Q><A><K><P><E><S><Q><P><R><A><A><E><K><R><P><A><E><D><Y><V><P><R><K><A><K><R><K><T><D><R><G><T><D><D><S><P><K><D><S><Q><E><D><L><Q><E><R><H><L><S><S><E><E><M><M><R><E><C><G><D><V><S><R><A><Q><E><E><L><R><K><K><Q><K><M><G><G><F><H><W><M><Q><R><D><V><Q><D><P><F><A><P><R><G><Q><R><G><V><R><G><V><R><G><G><G><R><G><Q><R><G><L><H><D><I><P><Y><L> | May be involved in transcriptional regulation.<BOP> | Q969E4 |
Q6DD88 | ATLA3_HUMAN | Atlastin-3 | Homo | <M><L><S><P><Q><R><V><A><A><A><A><S><R><G><A><D><D><A><M><E><S><S><K><P><G><P><V><Q><V><V><L><V><Q><K><D><Q><H><S><F><E><L><D><E><K><A><L><A><S><I><L><L><Q><D><H><I><R><D><L><D><V><V><V><V><S><V><A><G><A><F><R><K><G><K><S><F><I><L><D><F><M><L><R><Y><L><Y><S><Q><K><E><S><G><H><S><N><W><L><G><D><P><E><E><P><L><T><G><F><S><W><R><G><G><S><D><P><E><T><T><G><I><Q><I><W><S><E><V><F><T><V><E><K><P><G><G><K><K><V><A><V><V><L><M><D><T><Q><G><A><F><D><S><Q><S><T><V><K><D><C><A><T><I><F><A><L><S><T><M><T><S><S><V><Q><I><Y><N><L><S><Q><N><I><Q><E><D><D><L><Q><Q><L><Q><L><F><T><E><Y><G><R><L><A><M><D><E><I><F><Q><K><P><F><Q><T><L><M><F><L><V><R><D><W><S><F><P><Y><E><Y><S><Y><G><L><Q><G><G><M><A><F><L><D><K><R><L><Q><V><K><E><H><Q><H><E><E><I><Q><N><V><R><N><H><I><H><S><C><F><S><D><V><T><C><F><L><L><P><H><P><G><L><Q><V><A><T><S><P><D><F><D><G><K><L><K><D><I><A><G><E><F><K><E><Q><L><Q><A><L><I><P><Y><V><L><N><P><S><K><L><M><E><K><E><I><N><G><S><K><V><T><C><R><G><L><L><E><Y><F><K><A><Y><I><K><I><Y><Q><G><E><D><L><P><H><P><K><S><M><L><Q><A><T><A><E><A><N><N><L><A><A><A><A><S><A><K><D><I><Y><Y><N><N><M><E><E><V><C><G><G><E><K><P><Y><L><S><P><D><I><L><E><E><K><H><C><E><F><K><Q><L><A><L><D><H><F><K><K><T><K><K><M><G><G><K><D><F><S><F><R><Y><Q><Q><E><L><E><E><E><I><K><E><L><Y><E><N><F><C><K><H><N><G><S><K><N><V><F><S><T><F><R><T><P><A><V><L><F><T><G><I><V><A><L><Y><I><A><S><G><L><T><G><F><I><G><L><E><V><V><A><Q><L><F><N><C><M><V><G><L><L><L><I><A><L><L><T><W><G><Y><I><R><Y><S><G><Q><Y><R><E><L><G><G><A><I><D><F><G><A><A><Y><V><L><E><Q><A><S><S><H><I><G><N><S><T><Q><A><T><V><R><D><A><V><V><G><R><P><S><M><D><K><K><A><Q> | GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis .<BOP> | Q6DD88 |
P06126 | CD1A_HUMAN | T-cell surface antigen T6/Leu-6 | Homo | <M><L><F><L><L><L><P><L><L><A><V><L><P><G><D><G><N><A><D><G><L><K><E><P><L><S><F><H><V><T><W><I><A><S><F><Y><N><H><S><W><K><Q><N><L><V><S><G><W><L><S><D><L><Q><T><H><T><W><D><S><N><S><S><T><I><V><F><L><C><P><W><S><R><G><N><F><S><N><E><E><W><K><E><L><E><T><L><F><R><I><R><T><I><R><S><F><E><G><I><R><R><Y><A><H><E><L><Q><F><E><Y><P><F><E><I><Q><V><T><G><G><C><E><L><H><S><G><K><V><S><G><S><F><L><Q><L><A><Y><Q><G><S><D><F><V><S><F><Q><N><N><S><W><L><P><Y><P><V><A><G><N><M><A><K><H><F><C><K><V><L><N><Q><N><Q><H><E><N><D><I><T><H><N><L><L><S><D><T><C><P><R><F><I><L><G><L><L><D><A><G><K><A><H><L><Q><R><Q><V><K><P><E><A><W><L><S><H><G><P><S><P><G><P><G><H><L><Q><L><V><C><H><V><S><G><F><Y><P><K><P><V><W><V><M><W><M><R><G><E><Q><E><Q><Q><G><T><Q><R><G><D><I><L><P><S><A><D><G><T><W><Y><L><R><A><T><L><E><V><A><A><G><E><A><A><D><L><S><C><R><V><K><H><S><S><L><E><G><Q><D><I><V><L><Y><W><E><H><H><S><S><V><G><F><I><I><L><A><V><I><V><P><L><L><L><L><I><G><L><A><L><W><F><R><K><R><C><F><C> | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.<BOP> | P06126 |
O15391 | TYY2_HUMAN | Zinc finger protein 631 | Homo | <M><A><S><N><E><D><F><S><I><T><Q><D><L><E><I><P><A><D><I><V><E><L><H><D><I><N><V><E><P><L><P><M><E><D><I><P><T><E><S><V><Q><Y><E><D><V><D><G><N><W><I><Y><G><G><H><N><H><P><P><L><M><V><L><Q><P><L><F><T><N><T><G><Y><G><D><H><D><Q><E><M><L><M><L><Q><T><Q><E><E><V><V><G><Y><C><D><S><D><N><Q><L><G><N><D><L><E><D><Q><L><A><L><P><D><S><I><E><D><E><H><F><Q><M><T><L><A><S><L><S><A><S><A><A><S><T><S><T><S><T><Q><S><R><S><K><K><P><S><K><K><P><S><G><K><S><A><T><S><T><E><A><N><P><A><G><S><S><S><S><L><G><T><R><K><W><E><Q><K><Q><M><Q><V><K><T><L><E><G><E><F><S><V><T><M><W><S><P><N><D><N><N><D><Q><G><A><V><G><E><G><Q><A><E><N><P><P><D><Y><S><E><Y><L><K><G><K><K><L><P><P><G><G><L><P><G><I><D><L><S><D><P><K><Q><L><A><E><F><T><K><V><K><P><K><R><S><K><G><E><P><P><K><T><V><P><C><S><Y><S><G><C><E><K><M><F><R><D><Y><A><A><M><R><K><H><L><H><I><H><G><P><R><V><H><V><C><A><E><C><G><K><A><F><L><E><S><S><K><L><R><R><H><Q><L><V><H><T><G><E><K><P><F><Q><C><T><F><E><G><C><G><K><R><F><S><L><D><F><N><L><R><T><H><L><R><I><H><T><G><D><K><P><F><V><C><P><F><D><V><C><N><R><K><F><A><Q><S><T><N><L><K><T><H><I><L><T><H><V><K><T><K><N><N><P> | Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.<BOP> | O15391 |
Q9NQT4 | EXOS5_HUMAN | p12B | Homo | <M><E><E><E><T><H><T><D><A><K><I><R><A><E><N><G><T><G><S><S><P><R><G><P><G><C><S><L><R><H><F><A><C><E><Q><N><L><L><S><R><P><D><G><S><A><S><F><L><Q><G><D><T><S><V><L><A><G><V><Y><G><P><A><E><V><K><V><S><K><E><I><F><N><K><A><T><L><E><V><I><L><R><P><K><I><G><L><P><G><V><A><E><K><S><R><E><R><L><I><R><N><T><C><E><A><V><V><L><G><T><L><H><P><R><T><S><I><T><V><V><L><Q><V><V><S><D><A><G><S><L><L><A><C><C><L><N><A><A><C><M><A><L><V><D><A><G><V><P><M><R><A><L><F><C><G><V><A><C><A><L><D><S><D><G><T><L><V><L><D><P><T><S><K><Q><E><K><E><A><R><A><V><L><T><F><A><L><D><S><V><E><R><K><L><L><M><S><S><T><K><G><L><Y><S><D><T><E><L><Q><Q><C><L><A><A><A><Q><A><A><S><Q><H><V><F><R><F><Y><R><E><S><L><Q><R><R><Y><S><K><S> | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Ex | Q9NQT4 |
Q9UK23 | NAGPA_HUMAN | Phosphodiester alpha-GlcNAcase | Homo | <M><A><T><S><T><G><R><W><L><L><L><R><L><A><L><F><G><F><L><W><E><A><S><G><G><L><D><S><G><A><S><R><D><D><D><L><L><L><P><Y><P><R><A><R><A><R><L><P><R><D><C><T><R><V><R><A><G><N><R><E><H><E><S><W><P><P><P><P><A><T><P><G><A><G><G><L><A><V><R><T><F><V><S><H><F><R><D><R><A><V><A><G><H><L><T><R><A><V><E><P><L><R><T><F><S><V><L><E><P><G><G><P><G><G><C><A><A><R><R><R><A><T><V><E><E><T><A><R><A><A><D><C><R><V><A><Q><N><G><G><F><F><R><M><N><S><G><E><C><L><G><N><V><V><S><D><E><R><R><V><S><S><S><G><G><L><Q><N><A><Q><F><G><I><R><R><D><G><T><L><V><T><G><Y><L><S><E><E><E><V><L><D><T><E><N><P><F><V><Q><L><L><S><G><V><V><W><L><I><R><N><G><S><I><Y><I><N><E><S><Q><A><T><E><C><D><E><T><Q><E><T><G><S><F><S><K><F><V><N><V><I><S><A><R><T><A><I><G><H><D><R><K><G><Q><L><V><L><F><H><A><D><G><Q><T><E><Q><R><G><I><N><L><W><E><M><A><E><F><L><L><K><Q><D><V><V><N><A><I><N><L><D><G><G><G><S><A><T><F><V><L><N><G><T><L><A><S><Y><P><S><D><H><C><Q><D><N><M><W><R><C><P><R><Q><V><S><T><V><V><C><V><H><E><P><R><C><Q><P><P><D><C><H><G><H><G><T><C><V><D><G><H><C><Q><C><T><G><H><F><W><R><G><P><G><C><D><E><L><D><C><G><P><S><N><C><S><Q><H><G><L><C><T><E><T><G><C><R><C><D><A><G><W><T><G><S><N><C><S><E><E><C><P><L><G><W><H><G><P><G><C><Q><R><P><C><K><C><E><H><H><C><P><C><D><P><K><T><G><N><C><S><V><S><R><V><K><Q><C><L><Q><P><P><E><A><T><L><R><A><G><E><L><S><F><F><T><R><T><A><W><L><A><L><T><L><A><L><A><F><L><L><L><I><S><T><A><A><N><L><S><L><L><L><S><R><A><E><R><N><R><R><L><H><G><D><Y><A><Y><H><P><L><Q><E><M><N><G><E><P><L><A><A><E><K><E><Q><P><G><G><A><H><N><P><F><K><D> | Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.<BOP> | Q9UK23 |
O43639 | NCK2_HUMAN | SH2/SH3 adaptor protein NCK-beta | Homo | <M><T><E><E><V><I><V><I><A><K><W><D><Y><T><A><Q><Q><D><Q><E><L><D><I><K><K><N><E><R><L><W><L><L><D><D><S><K><T><W><W><R><V><R><N><A><A><N><R><T><G><Y><V><P><S><N><Y><V><E><R><K><N><S><L><K><K><G><S><L><V><K><N><L><K><D><T><L><G><L><G><K><T><R><R><K><T><S><A><R><D><A><S><P><T><P><S><T><D><A><E><Y><P><A><N><G><S><G><A><D><R><I><Y><D><L><N><I><P><A><F><V><K><F><A><Y><V><A><E><R><E><D><E><L><S><L><V><K><G><S><R><V><T><V><M><E><K><C><S><D><G><W><W><R><G><S><Y><N><G><Q><I><G><W><F><P><S><N><Y><V><L><E><E><V><D><E><A><A><A><E><S><P><S><F><L><S><L><R><K><G><A><S><L><S><N><G><Q><G><S><R><V><L><H><V><V><Q><T><L><Y><P><F><S><S><V><T><E><E><E><L><N><F><E><K><G><E><T><M><E><V><I><E><K><P><E><N><D><P><E><W><W><K><C><K><N><A><R><G><Q><V><G><L><V><P><K><N><Y><V><V><V><L><S><D><G><P><A><L><H><P><A><H><A><P><Q><I><S><Y><T><G><P><S><S><S><G><R><F><A><G><R><E><W><Y><Y><G><N><V><T><R><H><Q><A><E><C><A><L><N><E><R><G><V><E><G><D><F><L><I><R><D><S><E><S><S><P><S><D><F><S><V><S><L><K><A><S><G><K><N><K><H><F><K><V><Q><L><V><D><N><V><Y><C><I><G><Q><R><R><F><H><T><M><D><E><L><V><E><H><Y><K><K><A><P><I><F><T><S><E><H><G><E><K><L><Y><L><V><R><A><L><Q> | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<BOP> | O43639 |
Q12982 | BNIP2_HUMAN | BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 | Homo | <M><E><G><V><E><L><K><E><E><W><Q><D><E><D><F><P><I><P><L><P><E><D><D><S><I><E><A><D><I><L><A><I><T><G><P><E><D><Q><P><G><S><L><E><V><N><G><N><K><V><R><K><K><L><M><A><P><D><I><S><L><T><L><D><P><S><D><G><S><V><L><S><D><D><L><D><E><S><G><E><I><D><L><D><G><L><D><T><P><S><E><N><S><N><E><F><E><W><E><D><D><L><P><K><P><K><T><T><E><V><I><R><K><G><S><I><T><E><Y><T><A><A><E><E><K><E><D><G><R><R><W><R><M><F><R><I><G><E><Q><D><H><R><V><D><M><K><A><I><E><P><Y><K><K><V><I><S><H><G><G><Y><Y><G><D><G><L><N><A><I><V><V><F><A><V><C><F><M><P><E><S><S><Q><P><N><Y><R><Y><L><M><D><N><L><F><K><Y><V><I><G><T><L><E><L><L><V><A><E><N><Y><M><I><V><Y><L><N><G><A><T><T><R><R><K><M><P><S><L><G><W><L><R><K><C><Y><Q><Q><I><D><R><R><L><R><K><N><L><K><S><L><I><I><V><H><P><S><W><F><I><R><T><L><L><A><V><T><R><P><F><I><S><S><K><F><S><Q><K><I><R><Y><V><F><N><L><A><E><L><A><E><L><V><P><M><E><Y><V><G><I><P><E><C><I><K><Q><V><D><Q><E><L><N><G><K><Q><D><E><P><K><N><E><Q> | Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.<BOP> | Q12982 |
P01782 | HV309_HUMAN | Ig heavy chain V-III region DOB | Homo | <M><E><L><G><L><S><W><I><F><L><L><A><I><L><K><G><V><Q><C><E><V><Q><L><V><E><S><G><G><G><L><V><Q><P><G><R><S><L><R><L><S><C><A><A><S><G><F><T><F><D><D><Y><A><M><H><W><V><R><Q><A><P><G><K><G><L><E><W><V><S><G><I><S><W><N><S><G><S><I><G><Y><A><D><S><V><K><G><R><F><T><I><S><R><D><N><A><K><N><S><L><Y><L><Q><M><N><S><L><R><A><E><D><T><A><L><Y><Y><C><A><K><D> | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | P01782 |
Q9H9L4 | KANL2_HUMAN | Non-specific lethal 2 homolog | Homo | <M><N><R><I><R><I><H><V><L><P><T><N><R><G><R><I><T><P><V><P><R><S><Q><E><P><L><S><C><A><F><T><H><R><P><C><S><H><P><R><L><E><G><Q><E><F><C><I><K><H><I><L><E><D><K><N><A><P><F><K><Q><C><S><Y><I><S><T><K><N><G><K><R><C><P><N><A><A><P><K><P><E><K><K><D><G><V><S><F><C><A><E><H><V><R><R><N><A><L><A><L><H><A><Q><M><K><K><T><N><P><G><P><V><G><E><T><L><L><C><Q><L><S><S><Y><A><K><T><E><L><G><S><Q><T><P><E><S><S><R><S><E><A><S><R><I><L><D><E><D><S><W><S><D><G><E><Q><E><P><I><T><V><D><Q><T><W><R><G><D><P><D><S><E><A><D><S><I><D><S><D><Q><E><D><P><L><K><H><A><G><V><Y><T><A><E><E><V><A><L><I><M><R><E><K><L><I><R><L><Q><S><L><Y><I><D><Q><F><K><R><L><Q><H><L><L><K><E><K><K><R><R><Y><L><H><N><R><K><V><E><H><E><A><L><G><S><S><L><L><T><G><P><E><G><L><L><A><K><E><R><E><N><L><K><R><L><K><C><L><R><R><Y><R><Q><R><Y><G><V><E><A><L><L><H><R><Q><L><K><E><R><R><M><L><A><T><D><G><A><A><Q><Q><A><H><T><T><R><S><S><Q><R><C><L><A><F><V><D><D><V><R><C><S><N><Q><S><L><P><M><T><R><H><C><L><T><H><I><C><Q><D><T><N><Q><V><L><F><K><C><C><Q><G><S><E><E><V><P><C><N><K><P><V><P><V><S><L><S><E><D><P><C><C><P><L><H><F><Q><L><P><P><Q><M><Y><K><P><E><Q><V><L><S><V><P><D><D><L><E><A><G><P><M><D><L><Y><L><S><A><A><E><L><Q><P><T><E><S><L><P><L><E><F><S><D><D><L><D><V><V><G><D><G><M><Q><C><P><P><S><P><L><L><F><D><P><S><L><T><L><E><D><H><L><V><K><E><I><A><E><D><P><V><D><I><L><G><Q><M><Q><M><A><G><D><G><C><R><S><Q><G><S><R><N><S><E><K><A><S><A><P><L><S><Q><S><G><L><A><T><A><N><G><K><P><E><P><T><S><I><S> | As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.<BOP> | Q9H9L4 |
O00585 | CCL21_HUMAN | Small-inducible cytokine A21 | Homo | <M><A><Q><S><L><A><L><S><L><L><I><L><V><L><A><F><G><I><P><R><T><Q><G><S><D><G><G><A><Q><D><C><C><L><K><Y><S><Q><R><K><I><P><A><K><V><V><R><S><Y><R><K><Q><E><P><S><L><G><C><S><I><P><A><I><L><F><L><P><R><K><R><S><Q><A><E><L><C><A><D><P><K><E><L><W><V><Q><Q><L><M><Q><H><L><D><K><T><P><S><P><Q><K><P><A><Q><G><C><R><K><D><R><G><A><S><K><T><G><K><K><G><K><G><S><K><G><C><K><R><T><E><R><S><Q><T><P><K><G><P> | Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.<BOP> | O00585 |
Q9NWT6 | HIF1N_HUMAN | Hypoxia-inducible factor asparagine hydroxylase | Homo | <M><A><A><T><A><A><E><A><V><A><S><G><S><G><E><P><R><E><E><A><G><A><L><G><P><A><W><D><E><S><Q><L><R><S><Y><S><F><P><T><R><P><I><P><R><L><S><Q><S><D><P><R><A><E><E><L><I><E><N><E><E><P><V><V><L><T><D><T><N><L><V><Y><P><A><L><K><W><D><L><E><Y><L><Q><E><N><I><G><N><G><D><F><S><V><Y><S><A><S><T><H><K><F><L><Y><Y><D><E><K><K><M><A><N><F><Q><N><F><K><P><R><S><N><R><E><E><M><K><F><H><E><F><V><E><K><L><Q><D><I><Q><Q><R><G><G><E><E><R><L><Y><L><Q><Q><T><L><N><D><T><V><G><R><K><I><V><M><D><F><L><G><F><N><W><N><W><I><N><K><Q><Q><G><K><R><G><W><G><Q><L><T><S><N><L><L><L><I><G><M><E><G><N><V><T><P><A><H><Y><D><E><Q><Q><N><F><F><A><Q><I><K><G><Y><K><R><C><I><L><F><P><P><D><Q><F><E><C><L><Y><P><Y><P><V><H><H><P><C><D><R><Q><S><Q><V><D><F><D><N><P><D><Y><E><R><F><P><N><F><Q><N><V><V><G><Y><E><T><V><V><G><P><G><D><V><L><Y><I><P><M><Y><W><W><H><H><I><E><S><L><L><N><G><G><I><T><I><T><V><N><F><W><Y><K><G><A><P><T><P><K><R><I><E><Y><P><L><K><A><H><Q><K><V><A><I><M><R><N><I><E><K><M><L><G><E><A><L><G><N><P><Q><E><V><G><P><L><L><N><T><M><I><K><G><R><Y><N> | Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.<BOP> | Q9NWT6 |
Q8NEX9 | DR9C7_HUMAN | RDH-S | Homo | <M><A><A><L><T><D><L><S><F><M><Y><R><W><F><K><N><C><N><L><V><G><N><L><S><E><K><Y><V><F><I><T><G><C><D><S><G><F><G><N><L><L><A><K><Q><L><V><D><R><G><M><Q><V><L><A><A><C><F><T><E><E><G><S><Q><K><L><Q><R><D><T><S><Y><R><L><Q><T><T><L><L><D><V><T><K><S><E><S><I><K><A><A><A><Q><W><V><R><D><K><V><G><E><Q><G><L><W><A><L><V><N><N><A><G><V><G><L><P><S><G><P><N><E><W><L><T><K><D><D><F><V><K><V><I><N><V><N><L><V><G><L><I><E><V><T><L><H><M><L><P><M><V><K><R><A><R><G><R><V><V><N><M><S><S><S><G><G><R><V><A><V><I><G><G><G><Y><C><V><S><K><F><G><V><E><A><F><S><D><S><I><R><R><E><L><Y><Y><F><G><V><K><V><C><I><I><E><P><G><N><Y><R><T><A><I><L><G><K><E><N><L><E><S><R><M><R><K><L><W><E><R><L><P><Q><E><T><R><D><S><Y><G><E><D><Y><F><R><I><Y><T><D><K><L><K><N><I><M><Q><V><A><E><P><R><V><R><D><V><I><N><S><M><E><H><A><I><V><S><R><S><P><R><I><R><Y><N><P><G><L><D><A><K><L><L><Y><I><P><L><A><K><L><P><T><P><V><T><D><F><I><L><S><R><Y><L><P><R><P><A><D><S><V> | Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity.<BOP> | Q8NEX9 |
Q9UJ68 | MSRA_HUMAN | Protein-methionine-S-oxide reductase | Homo | <M><L><S><A><T><R><R><A><C><Q><L><L><L><L><H><S><L><F><P><V><P><R><M><G><N><S><A><S><N><I><V><S><P><Q><E><A><L><P><G><R><K><E><Q><T><P><V><A><A><K><H><H><V><N><G><N><R><T><V><E><P><F><P><E><G><T><Q><M><A><V><F><G><M><G><C><F><W><G><A><E><R><K><F><W><V><L><K><G><V><Y><S><T><Q><V><G><F><A><G><G><Y><T><S><N><P><T><Y><K><E><V><C><S><E><K><T><G><H><A><E><V><V><R><V><V><Y><Q><P><E><H><M><S><F><E><E><L><L><K><V><F><W><E><N><H><D><P><T><Q><G><M><R><Q><G><N><D><H><G><T><Q><Y><R><S><A><I><Y><P><T><S><A><K><Q><M><E><A><A><L><S><S><K><E><N><Y><Q><K><V><L><S><E><H><G><F><G><P><I><T><T><D><I><R><E><G><Q><T><F><Y><Y><A><E><D><Y><H><Q><Q><Y><L><S><K><N><P><N><G><Y><C><G><L><G><G><T><G><V><S><C><P><V><G><I><K><K> | Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.<BOP> | Q9UJ68 |
Q9BYT1 | S17A9_HUMAN | Solute carrier family 17 member 9 | Homo | <M><Q><P><P><P><D><E><A><R><R><D><M><A><G><D><T><Q><W><S><R><P><E><C><Q><A><W><T><G><T><L><L><L><G><T><C><L><L><Y><C><A><R><S><S><M><P><I><C><T><V><S><M><S><Q><D><F><G><W><N><K><K><E><A><G><I><V><L><S><S><F><F><W><G><Y><C><L><T><Q><V><V><G><G><H><L><G><D><R><I><G><G><E><K><V><I><L><L><S><A><S><A><W><G><S><I><T><A><V><T><P><L><L><A><H><L><S><S><A><H><L><A><F><M><T><F><S><R><I><L><M><G><L><L><Q><G><V><Y><F><P><A><L><T><S><L><L><S><Q><K><V><R><E><S><E><R><A><F><T><Y><S><I><V><G><A><G><S><Q><F><G><T><L><L><T><G><A><V><G><S><L><L><L><E><W><Y><G><W><Q><S><I><F><Y><F><S><G><G><L><T><L><L><W><V><W><Y><V><Y><R><Y><L><L><S><E><K><D><L><I><L><A><L><G><V><L><A><Q><S><R><P><V><S><R><H><N><R><V><P><W><R><R><L><F><R><K><P><A><V><W><A><A><V><V><S><Q><L><S><A><A><C><S><F><F><I><L><L><S><W><L><P><T><F><F><E><E><T><F><P><D><A><K><G><W><I><F><N><V><V><P><W><L><V><A><I><P><A><S><L><F><S><G><F><L><S><D><H><L><I><N><Q><G><Y><R><A><I><T><V><R><K><L><M><Q><G><M><G><L><G><L><S><S><V><F><A><L><C><L><G><H><T><S><S><F><C><E><S><V><V><F><A><S><A><S><I><G><L><Q><T><F><N><H><S><G><I><S><V><N><I><Q><D><L><A><P><S><C><A><G><F><L><F><G><V><A><N><T><A><G><A><L><A><G><V><V><G><V><C><L><G><G><Y><L><M><E><T><T><G><S><W><T><C><L><F><N><L><V><A><I><I><S><N><L><G><L><C><T><F><L><V><F><G><Q><A><Q><R><V><D><L><S><S><T><H><E><D><L> | Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles.<BOP> | Q9BYT1 |
Q7Z2G1 | H2BWT_HUMAN | H2B.W histone 1 | Homo | <M><L><R><T><E><V><P><R><L><P><R><S><T><T><A><I><V><W><S><C><H><L><M><A><T><A><S><A><M><A><G><P><S><S><E><T><T><S><E><E><Q><L><I><T><Q><E><P><K><E><A><N><S><T><T><S><Q><K><Q><S><K><Q><R><K><R><G><R><H><G><P><R><R><C><H><S><N><C><R><G><D><S><F><A><T><Y><F><R><R><V><L><K><Q><V><H><Q><G><L><S><L><S><R><E><A><V><S><V><M><D><S><L><V><H><D><I><L><D><R><I><A><T><E><A><G><R><L><A><R><S><T><K><R><Q><T><I><T><A><W><E><T><R><M><A><V><R><L><L><L><P><G><Q><M><G><K><L><A><E><S><E><G><T><K><A><V><L><R><T><S><L><Y><A><I><Q><Q><Q><R><K> | Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.<BOP> | Q7Z2G1 |
P19875 | CXCL2_HUMAN | SB-251353 | Homo | <M><A><R><A><T><L><S><A><A><P><S><N><P><R><L><L><R><V><A><L><L><L><L><L><L><V><A><A><S><R><R><A><A><G><A><P><L><A><T><E><L><R><C><Q><C><L><Q><T><L><Q><G><I><H><L><K><N><I><Q><S><V><K><V><K><S><P><G><P><H><C><A><Q><T><E><V><I><A><T><L><K><N><G><Q><K><A><C><L><N><P><A><S><P><M><V><K><K><I><I><E><K><M><L><K><N><G><K><S><N> | Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.<BOP> | P19875 |
Q9H4B4 | PLK3_HUMAN | Proliferation-related kinase | Homo | <M><E><P><A><A><G><F><L><S><P><R><P><F><Q><R><A><A><A><A><P><A><P><P><A><G><P><G><P><P><P><S><A><L><R><G><P><E><L><E><M><L><A><G><L><P><T><S><D><P><G><R><L><I><T><D><P><R><S><G><R><T><Y><L><K><G><R><L><L><G><K><G><G><F><A><R><C><Y><E><A><T><D><T><E><T><G><S><A><Y><A><V><K><V><I><P><Q><S><R><V><A><K><P><H><Q><R><E><K><I><L><N><E><I><E><L><H><R><D><L><Q><H><R><H><I><V><R><F><S><H><H><F><E><D><A><D><N><I><Y><I><F><L><E><L><C><S><R><K><S><L><A><H><I><W><K><A><R><H><T><L><L><E><P><E><V><R><Y><Y><L><R><Q><I><L><S><G><L><K><Y><L><H><Q><R><G><I><L><H><R><D><L><K><L><G><N><F><F><I><T><E><N><M><E><L><K><V><G><D><F><G><L><A><A><R><L><E><P><P><E><Q><R><K><K><T><I><C><G><T><P><N><Y><V><A><P><E><V><L><L><R><Q><G><H><G><P><E><A><D><V><W><S><L><G><C><V><M><Y><T><L><L><C><G><S><P><P><F><E><T><A><D><L><K><E><T><Y><R><C><I><K><Q><V><H><Y><T><L><P><A><S><L><S><L><P><A><R><Q><L><L><A><A><I><L><R><A><S><P><R><D><R><P><S><I><D><Q><I><L><R><H><D><F><F><T><K><G><Y><T><P><D><R><L><P><I><S><S><C><V><T><V><P><D><L><T><P><P><N><P><A><R><S><L><F><A><K><V><T><K><S><L><F><G><R><K><K><K><S><K><N><H><A><Q><E><R><D><E><V><S><G><L><V><S><G><L><M><R><T><S><V><G><H><Q><D><A><R><P><E><A><P><A><A><S><G><P><A><P><V><S><L><V><E><T><A><P><E><D><S><S><P><R><G><T><L><A><S><S><G><D><G><F><E><E><G><L><T><V><A><T><V><V><E><S><A><L><C><A><L><R><N><C><I><A><F><M><P><P><A><E><Q><N><P><A><P><L><A><Q><P><E><P><L><V><W><V><S><K><W><V><D><Y><S><N><K><F><G><F><G><Y><Q><L><S><S><R><R><V><A><V><L><F><N><D><G><T><H><M><A><L><S><A><N><R><K><T><V><H><Y><N><P><T><S><T><K><H><F><S><F><S><V><G><A><V><P><R><A><L><Q><P><Q><L><G><I><L><R><Y><F><A><S><Y><M><E><Q><H><L><M><K><G><G><D><L><P><S><V><E><E><V><E><V><P><A><P><P><L><L><L><Q><W><V><K><T><D><Q><A><L><L><M><L><F><S><D><G><T><V><Q><V><N><F><Y><G><D><H><T><K><L><I><L><S><G><W><E><P><L><L><V><T><F><V><A><R><N><R><S><A><C><T><Y><L><A><S><H><L><R><Q><L><G><C><S><P><D><L><R><Q><R><L><R><Y><A><L><R><L><L><R><D><R><S><P><A> | Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby | Q9H4B4 |
Q14397 | GCKR_HUMAN | Glucokinase regulatory protein | Homo | <M><P><G><T><K><R><F><Q><H><V><I><E><T><P><E><P><G><K><W><E><L><S><G><Y><E><A><A><V><P><I><T><E><K><S><N><P><L><T><Q><D><L><D><K><A><D><A><E><N><I><V><R><L><L><G><Q><C><D><A><E><I><F><Q><E><E><G><Q><A><L><S><T><Y><Q><R><L><Y><S><E><S><I><L><T><T><M><V><Q><V><A><G><K><V><Q><E><V><L><K><E><P><D><G><G><L><V><V><L><S><G><G><G><T><S><G><R><M><A><F><L><M><S><V><S><F><N><Q><L><M><K><G><L><G><Q><K><P><L><Y><T><Y><L><I><A><G><G><D><R><S><V><V><A><S><R><E><G><T><E><D><S><A><L><H><G><I><E><E><L><K><K><V><A><A><G><K><K><R><V><I><V><I><G><I><S><V><G><L><S><A><P><F><V><A><G><Q><M><D><C><C><M><N><N><T><A><V><F><L><P><V><L><V><G><F><N><P><V><S><M><A><R><N><D><P><I><E><D><W><S><S><T><F><R><Q><V><A><E><R><M><Q><K><M><Q><E><K><Q><K><A><F><V><L><N><P><A><I><G><P><E><G><L><S><G><S><S><R><M><K><G><G><S><A><T><K><I><L><L><E><T><L><L><L><A><A><H><K><T><V><D><Q><G><I><A><A><S><Q><R><C><L><L><E><I><L><R><T><F><E><R><A><H><Q><V><T><Y><S><Q><S><P><K><I><A><T><L><M><K><S><V><S><T><S><L><E><K><K><G><H><V><Y><L><V><G><W><Q><T><L><G><I><I><A><I><M><D><G><V><E><C><I><H><T><F><G><A><D><F><R><D><V><R><G><F><L><I><G><D><H><S><D><M><F><N><Q><K><A><E><L><T><N><Q><G><P><Q><F><T><F><S><Q><E><D><F><L><T><S><I><L><P><S><L><T><E><I><D><T><V><V><F><I><F><T><L><D><D><N><L><T><E><V><Q><T><I><V><E><Q><V><K><E><K><T><N><H><I><Q><A><L><A><H><S><T><V><G><Q><T><L><P><I><P><L><K><K><L><F><P><S><I><I><S><I><T><W><P><L><L><F><F><E><Y><E><G><N><F><I><Q><K><F><Q><R><E><L><S><T><K><W><V><L><N><T><V><S><T><G><A><H><V><L><L><G><K><I><L><Q><N><H><M><L><D><L><R><I><S><N><S><K><L><F><W><R><A><L><A><M><L><Q><R><F><S><G><Q><S><K><A><R><C><I><E><S><L><L><R><A><I><H><F><P><Q><P><L><S><D><D><I><R><A><A><P><I><S><C><H><V><Q><V><A><H><E><K><E><Q><V><I><P><I><A><L><L><S><L><L><F><R><C><S><I><T><E><A><Q><A><H><L><A><A><A><P><S><V><C><E><A><V><R><S><A><L><A><G><P><G><Q><K><R><T><A><D><P><L><E><I><L><E><P><D><V><Q> | Regulates glucokinase (GCK) by forming an inactive complex with this enzyme . Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal . The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity .<BOP> | Q14397 |
P43364 | MAGAB_HUMAN | MAGE-11 antigen | Homo | <M><E><T><Q><F><R><R><G><G><L><G><C><S><P><A><S><I><K><R><K><K><K><R><E><D><S><G><D><F><G><L><Q><V><S><T><M><F><S><E><D><D><F><Q><S><T><E><R><A><P><Y><G><P><Q><L><Q><W><S><Q><D><L><P><R><V><Q><V><F><R><E><Q><A><N><L><E><D><R><S><P><R><R><T><Q><R><I><T><G><G><E><Q><V><L><W><G><P><I><T><Q><I><F><P><T><V><R><P><A><D><L><T><R><V><I><M><P><L><E><Q><R><S><Q><H><C><K><P><E><E><G><L><Q><A><Q><E><E><D><L><G><L><V><G><A><Q><A><L><Q><A><E><E><Q><E><A><A><F><F><S><S><T><L><N><V><G><T><L><E><E><L><P><A><A><E><S><P><S><P><P><Q><S><P><Q><E><E><S><F><S><P><T><A><M><D><A><I><F><G><S><L><S><D><E><G><S><G><S><Q><E><K><E><G><P><S><T><S><P><D><L><I><D><P><E><S><F><S><Q><D><I><L><H><D><K><I><I><D><L><V><H><L><L><L><R><K><Y><R><V><K><G><L><I><T><K><A><E><M><L><G><S><V><I><K><N><Y><E><D><Y><F><P><E><I><F><R><E><A><S><V><C><M><Q><L><L><F><G><I><D><V><K><E><V><D><P><T><S><H><S><Y><V><L><V><T><S><L><N><L><S><Y><D><G><I><Q><C><N><E><Q><S><M><P><K><S><G><L><L><I><I><V><L><G><V><I><F><M><E><G><N><C><I><P><E><E><V><M><W><E><V><L><S><I><M><G><V><Y><A><G><R><E><H><F><L><F><G><E><P><K><R><L><L><T><Q><N><W><V><Q><E><K><Y><L><V><Y><R><Q><V><P><G><T><D><P><A><C><Y><E><F><L><W><G><P><R><A><H><A><E><T><S><K><M><K><V><L><E><Y><I><A><N><A><N><G><R><D><P><T><S><Y><P><S><L><Y><E><D><A><L><R><E><E><G><E><G><V> | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.<BOP> | P43364 |
P49914 | MTHFS_HUMAN | 5,10-methenyl-tetrahydrofolate synthetase | Homo | <M><A><A><A><A><V><S><S><A><K><R><S><L><R><G><E><L><K><Q><R><L><R><A><M><S><A><E><E><R><L><R><Q><S><R><V><L><S><Q><K><V><I><A><H><S><E><Y><Q><K><S><K><R><I><S><I><F><L><S><M><Q><D><E><I><E><T><E><E><I><I><K><D><I><F><Q><R><G><K><I><C><F><I><P><R><Y><R><F><Q><S><N><H><M><D><M><V><R><I><E><S><P><E><E><I><S><L><L><P><K><T><S><W><N><I><P><Q><P><G><E><G><D><V><R><E><E><A><L><S><T><G><G><L><D><L><I><F><M><P><G><L><G><F><D><K><H><G><N><R><L><G><R><G><K><G><Y><Y><D><A><Y><L><K><R><C><L><Q><H><Q><E><V><K><P><Y><T><L><A><L><A><F><K><E><Q><I><C><L><Q><V><P><V><N><E><N><D><M><K><V><D><E><V><L><Y><E><D><S><S><T><A> | Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.<BOP> | P49914 |
P78549 | NTH_HUMAN | Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase | Homo | <M><C><S><P><Q><E><S><G><M><T><A><L><S><A><R><M><L><T><R><S><R><S><L><G><P><G><A><G><P><R><G><C><R><E><E><P><G><P><L><R><R><R><E><A><A><A><E><A><R><K><S><H><S><P><V><K><R><P><R><K><A><Q><R><L><R><V><A><Y><E><G><S><D><S><E><K><G><E><G><A><E><P><L><K><V><P><V><W><E><P><Q><D><W><Q><Q><Q><L><V><N><I><R><A><M><R><N><K><K><D><A><P><V><D><H><L><G><T><E><H><C><Y><D><S><S><A><P><P><K><V><R><R><Y><Q><V><L><L><S><L><M><L><S><S><Q><T><K><D><Q><V><T><A><G><A><M><Q><R><L><R><A><R><G><L><T><V><D><S><I><L><Q><T><D><D><A><T><L><G><K><L><I><Y><P><V><G><F><W><R><S><K><V><K><Y><I><K><Q><T><S><A><I><L><Q><Q><H><Y><G><G><D><I><P><A><S><V><A><E><L><V><A><L><P><G><V><G><P><K><M><A><H><L><A><M><A><V><A><W><G><T><V><S><G><I><A><V><D><T><H><V><H><R><I><A><N><R><L><R><W><T><K><K><A><T><K><S><P><E><E><T><R><A><A><L><E><E><W><L><P><R><E><L><W><H><E><I><N><G><L><L><V><G><F><G><Q><Q><T><C><L><P><V><H><P><R><C><H><A><C><L><N><Q><A><L><C><P><A><A><Q><G><L> | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage . The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.<BOP> | P78549 |
P49591 | SYSC_HUMAN | Seryl-tRNA(Ser/Sec) synthetase | Homo | <M><V><L><D><L><D><L><F><R><V><D><K><G><G><D><P><A><L><I><R><E><T><Q><E><K><R><F><K><D><P><G><L><V><D><Q><L><V><K><A><D><S><E><W><R><R><C><R><F><R><A><D><N><L><N><K><L><K><N><L><C><S><K><T><I><G><E><K><M><K><K><K><E><P><V><G><D><D><E><S><V><P><E><N><V><L><S><F><D><D><L><T><A><D><A><L><A><N><L><K><V><S><Q><I><K><K><V><R><L><L><I><D><E><A><I><L><K><C><D><A><E><R><I><K><L><E><A><E><R><F><E><N><L><R><E><I><G><N><L><L><H><P><S><V><P><I><S><N><D><E><D><V><D><N><K><V><E><R><I><W><G><D><C><T><V><R><K><K><Y><S><H><V><D><L><V><V><M><V><D><G><F><E><G><E><K><G><A><V><V><A><G><S><R><G><Y><F><L><K><G><V><L><V><F><L><E><Q><A><L><I><Q><Y><A><L><R><T><L><G><S><R><G><Y><I><P><I><Y><T><P><F><F><M><R><K><E><V><M><Q><E><V><A><Q><L><S><Q><F><D><E><E><L><Y><K><V><I><G><K><G><S><E><K><S><D><D><N><S><Y><D><E><K><Y><L><I><A><T><S><E><Q><P><I><A><A><L><H><R><D><E><W><L><R><P><E><D><L><P><I><K><Y><A><G><L><S><T><C><F><R><Q><E><V><G><S><H><G><R><D><T><R><G><I><F><R><V><H><Q><F><E><K><I><E><Q><F><V><Y><S><S><P><H><D><N><K><S><W><E><M><F><E><E><M><I><T><T><A><E><E><F><Y><Q><S><L><G><I><P><Y><H><I><V><N><I><V><S><G><S><L><N><H><A><A><S><K><K><L><D><L><E><A><W><F><P><G><S><G><A><F><R><E><L><V><S><C><S><N><C><T><D><Y><Q><A><R><R><L><R><I><R><Y><G><Q><T><K><K><M><M><D><K><V><E><F><V><H><M><L><N><A><T><M><C><A><T><T><R><T><I><C><A><I><L><E><N><Y><Q><T><E><K><G><I><T><V><P><E><K><L><K><E><F><M><P><P><G><L><Q><E><L><I><P><F><V><K><P><A><P><I><E><Q><E><P><S><K><K><Q><K><K><Q><H><E><G><S><K><K><K><A><A><A><R><D><V><T><L><E><N><R><L><Q><N><M><E><V><T><D><A> | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) . Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) . In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC . Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA .<BOP> | P49591 |
P00395 | COX1_HUMAN | Cytochrome c oxidase polypeptide I | Homo | <M><F><A><D><R><W><L><F><S><T><N><H><K><D><I><G><T><L><Y><L><L><F><G><A><W><A><G><V><L><G><T><A><L><S><L><L><I><R><A><E><L><G><Q><P><G><N><L><L><G><N><D><H><I><Y><N><V><I><V><T><A><H><A><F><V><M><I><F><F><M><V><M><P><I><M><I><G><G><F><G><N><W><L><V><P><L><M><I><G><A><P><D><M><A><F><P><R><M><N><N><M><S><F><W><L><L><P><P><S><L><L><L><L><L><A><S><A><M><V><E><A><G><A><G><T><G><W><T><V><Y><P><P><L><A><G><N><Y><S><H><P><G><A><S><V><D><L><T><I><F><S><L><H><L><A><G><V><S><S><I><L><G><A><I><N><F><I><T><T><I><I><N><M><K><P><P><A><M><T><Q><Y><Q><T><P><L><F><V><W><S><V><L><I><T><A><V><L><L><L><L><S><L><P><V><L><A><A><G><I><T><M><L><L><T><D><R><N><L><N><T><T><F><F><D><P><A><G><G><G><D><P><I><L><Y><Q><H><L><F><W><F><F><G><H><P><E><V><Y><I><L><I><L><P><G><F><G><M><I><S><H><I><V><T><Y><Y><S><G><K><K><E><P><F><G><Y><M><G><M><V><W><A><M><M><S><I><G><F><L><G><F><I><V><W><A><H><H><M><F><T><V><G><M><D><V><D><T><R><A><Y><F><T><S><A><T><M><I><I><A><I><P><T><G><V><K><V><F><S><W><L><A><T><L><H><G><S><N><M><K><W><S><A><A><V><L><W><A><L><G><F><I><F><L><F><T><V><G><G><L><T><G><I><V><L><A><N><S><S><L><D><I><V><L><H><D><T><Y><Y><V><V><A><H><F><H><Y><V><L><S><M><G><A><V><F><A><I><M><G><G><F><I><H><W><F><P><L><F><S><G><Y><T><L><D><Q><T><Y><A><K><I><H><F><T><I><M><F><I><G><V><N><L><T><F><F><P><Q><H><F><L><G><L><S><G><M><P><R><R><Y><S><D><Y><P><D><A><Y><T><T><W><N><I><L><S><S><V><G><S><F><I><S><L><T><A><V><M><L><M><I><F><M><I><W><E><A><F><A><S><K><R><K><V><L><M><V><E><E><P><S><M><N><L><E><W><L><Y><G><C><P><P><P><Y><H><T><F><E><E><P><V><Y><M><K><S> | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from | P00395 |
Q96R72 | OR4K3_HUMAN | Olfactory receptor OR14-14 | Homo | <M><A><W><S><N><Q><S><A><V><T><E><F><I><L><R><G><L><S><S><S><L><E><L><Q><I><F><Y><F><L><F><F><S><I><V><Y><A><A><T><V><L><G><N><L><L><I><V><V><T><I><A><S><E><P><H><L><H><S><P><M><Y><F><L><L><G><N><L><S><F><I><D><M><S><L><A><S><F><A><T><P><K><M><I><A><D><F><L><R><E><H><K><A><I><S><F><E><G><C><M><T><Q><M><F><F><L><H><L><L><G><G><A><E><I><V><L><L><I><S><M><S><F><D><R><Y><V><A><I><C><K><P><L><H><Y><L><T><I><M><S><R><R><M><C><V><G><L><V><I><L><S><W><I><V><G><I><F><H><A><L><S><Q><L><A><F><T><V><N><L><P><F><C><G><P><N><E><V><D><S><F><F><C><D><L><P><L><V><I><K><L><A><C><V><D><T><Y><I><L><G><V><F><M><I><S><T><S><G><M><I><A><L><V><C><F><I><L><L><V><I><S><Y><T><I><I><L><V><T><V><R><Q><R><S><S><G><G><S><S><K><A><L><S><T><C><S><A><H><F><T><V><V><T><L><F><F><G><P><C><T><F><I><Y><V><W><P><F><T><N><F><P><I><D><K><V><L><S><V><F><Y><T><I><Y><T><P><L><L><N><P><V><I><Y><T><V><R><N><K><D><V><K><Y><S><M><R><K><L><S><S><H><I><F><K><S><R><K><T><D><H><T><P> | Odorant receptor.<BOP> | Q96R72 |
Q92844 | TANK_HUMAN | TRAF-interacting protein | Homo | <M><D><K><N><I><G><E><Q><L><N><K><A><Y><E><A><F><R><Q><A><C><M><D><R><D><S><A><V><K><E><L><Q><Q><K><T><E><N><Y><E><Q><R><I><R><E><Q><Q><E><Q><L><S><L><Q><Q><T><I><I><D><K><L><K><S><Q><L><L><L><V><N><S><T><Q><D><N><N><Y><G><C><V><P><L><L><E><D><S><E><T><R><K><N><N><L><T><L><D><Q><P><Q><D><K><V><I><S><G><I><A><R><E><K><L><P><K><V><R><R><Q><E><V><S><S><P><R><K><E><T><S><A><R><S><L><G><S><P><L><L><H><E><R><G><N><I><E><K><T><F><W><D><L><K><E><E><F><H><K><I><C><M><L><A><K><A><Q><K><D><H><L><S><K><L><N><I><P><D><T><A><T><E><T><Q><C><S><V><P><I><Q><C><T><D><K><T><D><K><Q><E><A><L><F><K><P><Q><A><K><D><D><I><N><R><G><A><P><S><I><T><S><V><T><P><R><G><L><C><R><D><E><E><D><T><S><F><E><S><L><S><K><F><N><V><K><F><P><P><M><D><N><D><S><T><F><L><H><S><T><P><E><R><P><G><I><L><S><P><A><T><S><E><A><V><C><Q><E><K><F><N><M><E><F><R><D><N><P><G><N><F><V><K><T><E><E><T><L><F><E><I><Q><G><I><D><P><I><A><S><A><I><Q><N><L><K><T><T><D><K><T><K><P><S><N><L><V><N><T><C><I><R><T><T><L><D><R><A><A><C><L><P><P><G><D><H><N><A><L><Y><V><N><S><F><P><L><L><D><P><S><D><A><P><F><P><S><L><D><S><P><G><K><A><I><R><G><P><Q><Q><P><I><W><K><P><F><P><N><Q><D><S><D><S><V><V><L><S><G><T><D><S><E><L><H><I><P><R><V><C><E><F><C><Q><A><V><F><P><P><S><I><T><S><R><G><D><F><L><R><H><L><N><S><H><F><N><G><E><T> | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage . Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage . Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage . May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.<BOP> | Q92844 |
P01893 | HLAH_HUMAN | MHC class I antigen H | Homo | <M><V><L><M><A><P><R><T><L><L><L><L><L><S><G><A><L><A><L><T><Q><T><W><A><R><S><H><S><M><R><Y><F><Y><T><T><M><S><R><P><G><A><G><E><P><R><F><I><S><V><G><Y><V><D><D><T><Q><F><V><R><F><D><S><D><D><A><S><P><R><E><E><P><R><A><P><W><M><E><R><E><G><P><K><Y><W><D><R><N><T><Q><I><C><K><A><Q><A><Q><T><E><R><E><N><L><R><I><A><L><R><Y><Y><N><Q><S><E><G><G><S><H><T><M><Q><V><M><Y><G><C><D><V><G><P><D><G><P><F><L><R><G><Y><E><Q><H><A><Y><D><G><K><D><Y><I><A><L><N><E><D><L><R><S><W><T><A><A><D><M><A><A><Q><I><T><K><R><K><W><E><A><A><R><R><A><E><Q><R><R><V><Y><L><E><G><E><F><V><E><W><L><R><R><Y><L><E><N><G><K><E><T><L><Q><R><A><D><P><P><K><T><H><M><T><H><H><P><I><S><D><H><E><A><T><L><R><C><W><A><L><G><F><Y><P><A><E><I><T><L><T><W><Q><R><D><G><E><D><Q><T><Q><D><T><E><L><V><E><T><R><P><A><G><D><G><T><F><Q><K><W><A><A><V><V><V><P><S><G><E><E><Q><R><Y><T><C><H><V><Q><H><E><G><L><P><E><P><L><T><L><R><W><E><P><S><S><Q><P><T><V><P><I><V><G><I><V><A><G><L><V><L><L><V><A><V><V><T><G><A><V><V><A><A><V><M><W><R><K><K><S><S><D><R><K><G><G><S><Y><S><Q><A><A><S><S><N><S><A><Q><G><S><D><V><S><L><T><A> | Involved in the presentation of foreign antigens to the immune system.<BOP> | P01893 |
P55789 | ALR_HUMAN | Hepatopoietin | Homo | <M><A><A><P><G><E><R><G><R><F><H><G><G><N><L><F><F><L><P><G><G><A><R><S><E><M><M><D><D><L><A><T><D><A><R><G><R><G><A><G><R><R><D><A><A><A><S><A><S><T><P><A><Q><A><P><T><S><D><S><P><V><A><E><D><A><S><R><R><R><P><C><R><A><C><V><D><F><K><T><W><M><R><T><Q><Q><K><R><D><T><K><F><R><E><D><C><P><P><D><R><E><E><L><G><R><H><S><W><A><V><L><H><T><L><A><A><Y><Y><P><D><L><P><T><P><E><Q><Q><Q><D><M><A><Q><F><I><H><L><F><S><K><F><Y><P><C><E><E><C><A><E><D><L><R><K><R><L><C><R><N><H><P><D><T><R><T><R><A><C><F><T><Q><W><L><C><H><L><H><N><E><V><N><R><K><L><G><K><P><D><F><D><C><S><K><V><D><E><R><W><R><D><G><W><K><D><G><S><C><D> | May act as an autocrine hepatotrophic growth factor promoting liver regeneration.<BOP> | P55789 |
Q9BTM9 | URM1_HUMAN | Ubiquitin-related modifier 1 | Homo | <M><A><A><P><L><S><V><E><V><E><F><G><G><G><A><E><L><L><F><D><G><I><K><K><H><R><V><T><L><P><G><Q><E><E><P><W><D><I><R><N><L><L><I><W><I><K><K><N><L><L><K><E><R><P><E><L><F><I><Q><G><D><S><V><R><P><G><I><L><V><L><I><N><D><A><D><W><E><L><L><G><E><L><D><Y><Q><L><Q><D><Q><D><S><V><L><F><I><S><T><L><H><G><G> | Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.<BOP> | Q9BTM9 |
P06703 | S10A6_HUMAN | S100 calcium-binding protein A6 | Homo | <M><A><C><P><L><D><Q><A><I><G><L><L><V><A><I><F><H><K><Y><S><G><R><E><G><D><K><H><T><L><S><K><K><E><L><K><E><L><I><Q><K><E><L><T><I><G><S><K><L><Q><D><A><E><I><A><R><L><M><E><D><L><D><R><N><K><D><Q><E><V><N><F><Q><E><Y><V><T><F><L><G><A><L><A><L><I><Y><N><E><A><L><K><G> | May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.<BOP> | P06703 |
Q86V40 | TIKI1_HUMAN | TRAB domain-containing protein 2A | Homo | <M><S><P><W><S><W><F><L><L><Q><T><L><C><L><L><P><T><G><A><A><S><R><R><G><A><P><G><T><A><N><C><E><L><K><P><Q><Q><S><E><L><N><S><F><L><W><T><I><K><R><D><P><P><S><Y><F><F><G><T><I><H><V><P><Y><T><R><V><W><D><F><I><P><D><N><S><K><E><A><F><L><Q><S><S><I><V><Y><F><E><L><D><L><T><D><P><Y><T><I><S><A><L><T><S><C><Q><M><L><P><Q><G><E><N><L><Q><D><V><L><P><R><D><I><Y><C><R><L><K><R><H><L><E><Y><V><K><L><M><M><P><L><W><M><T><P><D><Q><R><G><K><G><L><Y><A><D><Y><L><F><N><A><I><A><G><N><W><E><R><K><R><P><V><W><V><M><L><M><V><N><S><L><T><E><V><D><I><K><S><R><G><V><P><V><L><D><L><F><L><A><Q><E><A><E><R><L><R><K><Q><T><G><A><V><E><K><V><E><E><Q><C><H><P><L><N><G><L><N><F><S><Q><V><I><F><A><L><N><Q><T><L><L><Q><Q><E><S><L><R><A><G><S><L><Q><I><P><Y><T><T><E><D><L><I><K><H><Y><N><C><G><D><L><S><S><V><I><L><S><H><D><S><S><Q><V><P><N><F><I><N><A><T><L><P><P><Q><E><R><I><T><A><Q><E><I><D><S><Y><L><R><R><E><L><I><Y><K><R><N><E><R><I><G><K><R><V><K><A><L><L><E><E><F><P><D><K><G><F><F><F><A><F><G><A><G><H><F><M><G><N><N><T><V><L><D><V><L><R><R><E><G><Y><E><V><E><H><A><P><A><G><R><P><I><H><K><G><K><S><K><K><T><S><T><R><P><T><L><S><T><I><F><A><P><K><V><P><T><L><E><V><P><A><P><E><A><V><S><S><G><H><S><T><L><P><P><L><V><S><R><P><G><S><A><D><T><P><S><E><A><E><Q><R><F><R><K><K><R><R><R><S><Q><R><R><P><R><L><R><Q><F><S><D><L><W><V><R><L><E><E><S><D><I><V><P><Q><L><Q><V><P><V><L><D><R><H><I><S><T><E><L><R><L><P><R><R><G><H><S><H><H><S><Q><M><V><A><S><S><A><C><L><S><L><W><T><P><V><F><W><V><L><V><L><A><F><Q><T><E><T><P><L><L> | Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.<BOP> | Q86V40 |
Q9H6X2 | ANTR1_HUMAN | Tumor endothelial marker 8 | Homo | <M><A><T><A><E><R><R><A><L><G><I><G><F><Q><W><L><S><L><A><T><L><V><L><I><C><A><G><Q><G><G><R><R><E><D><G><G><P><A><C><Y><G><G><F><D><L><Y><F><I><L><D><K><S><G><S><V><L><H><H><W><N><E><I><Y><Y><F><V><E><Q><L><A><H><K><F><I><S><P><Q><L><R><M><S><F><I><V><F><S><T><R><G><T><T><L><M><K><L><T><E><D><R><E><Q><I><R><Q><G><L><E><E><L><Q><K><V><L><P><G><G><D><T><Y><M><H><E><G><F><E><R><A><S><E><Q><I><Y><Y><E><N><R><Q><G><Y><R><T><A><S><V><I><I><A><L><T><D><G><E><L><H><E><D><L><F><F><Y><S><E><R><E><A><N><R><S><R><D><L><G><A><I><V><Y><C><V><G><V><K><D><F><N><E><T><Q><L><A><R><I><A><D><S><K><D><H><V><F><P><V><N><D><G><F><Q><A><L><Q><G><I><I><H><S><I><L><K><K><S><C><I><E><I><L><A><A><E><P><S><T><I><C><A><G><E><S><F><Q><V><V><V><R><G><N><G><F><R><H><A><R><N><V><D><R><V><L><C><S><F><K><I><N><D><S><V><T><L><N><E><K><P><F><S><V><E><D><T><Y><L><L><C><P><A><P><I><L><K><E><V><G><M><K><A><A><L><Q><V><S><M><N><D><G><L><S><F><I><S><S><S><V><I><I><T><T><T><H><C><S><D><G><S><I><L><A><I><A><L><L><I><L><F><L><L><L><A><L><A><L><L><W><W><F><W><P><L><C><C><T><V><I><I><K><E><V><P><P><P><P><A><E><E><S><E><E><E><D><D><D><G><L><P><K><K><K><W><P><T><V><D><A><S><Y><Y><G><G><R><G><V><G><G><I><K><R><M><E><V><R><W><G><E><K><G><S><T><E><E><G><A><K><L><E><K><A><K><N><A><R><V><K><M><P><E><Q><E><Y><E><F><P><E><P><R><N><L><N><N><N><M><R><R><P><S><S><P><R><K><W><Y><S><P><I><K><G><K><L><D><A><L><W><V><L><L><R><K><G><Y><D><R><V><S><V><M><R><P><Q><P><G><D><T><G><R><C><I><N><F><T><R><V><K><N><N><Q><P><A><K><Y><P><L><N><N><A><Y><H><T><S><S><P><P><P><A><P><I><Y><T><P><P><P><P><A><P><H><C><P><P><P><P><P><S><A><P><T><P><P><I><P><S><P><P><S><T><L><P><P><P><P><Q><A><P><P><P><N><R><A><P><P><P><S><R><P><P><P><R><P><S><V> | (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis.<BOP> | Q9H6X2 |
Q9H6V9 | LDAH_HUMAN | Lipid droplet-associated serine hydrolase | Homo | <M><D><S><E><L><K><E><E><I><P><V><H><E><E><F><I><L><C><G><G><A><E><T><Q><V><L><K><C><G><P><W><T><D><L><F><H><D><Q><S><V><K><R><P><K><L><L><I><F><I><I><P><G><N><P><G><F><S><A><F><Y><V><P><F><A><K><A><L><Y><S><L><T><N><R><R><F><P><V><W><T><I><S><H><A><G><H><A><L><A><P><K><D><K><K><I><L><T><T><S><E><D><S><N><A><Q><E><I><K><D><I><Y><G><L><N><G><Q><I><E><H><K><L><A><F><L><R><T><H><V><P><K><D><M><K><L><V><L><I><G><H><S><I><G><S><Y><F><T><L><Q><M><L><K><R><V><P><E><L><P><V><I><R><A><F><L><L><F><P><T><I><E><R><M><S><E><S><P><N><G><R><I><A><T><P><L><L><C><W><F><R><Y><V><L><Y><V><T><G><Y><L><L><L><K><P><C><P><E><T><I><K><S><L><L><I><R><R><G><L><Q><V><M><N><L><E><N><E><F><S><P><L><N><I><L><E><P><F><C><L><A><N><A><A><Y><L><G><G><Q><E><M><M><E><V><V><K><R><D><D><E><T><I><K><E><H><L><C><K><L><T><F><Y><Y><G><T><I><D><P><W><C><P><K><E><Y><Y><E><D><I><K><K><D><F><P><E><G><D><I><R><L><C><E><K><N><I><P><H><A><F><I><T><H><F><N><Q><E><M><A><D><M><I><A><D><S><L><K><D><D><L><S><K><M> | Probable serine lipid hydrolase associated with lipid droplets. Appears to lack cholesterol esterase activity. Appears to lack triglyceride lipase activity. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.<BOP> | Q9H6V9 |
Q96R84 | OR1F2_HUMAN | OLFmf2 | Homo | <M><E><R><D><K><P><V><S><V><S><E><F><L><L><L><G><L><S><R><Q><P><Q><Q><Q><H><L><L><F><V><F><F><L><S><M><Y><L><A><T><V><L><G><N><L><L><I><I><L><A><I><S><I><D><S><R><L><H><T><P><M><Y><F><F><L><S><N><M><S><F><V><D><N><C><F><S><T><T><V><P><K><M><L><A><N><H><I><L><R><T><Q><T><I><S><F><S><G><C><L><M><Q><M><Y><F><I><S><E><L><A><D><M><D><N><F><L><L><A><V><M><A><Y><D><R><F><V><A><V><C><R><P><L><H><Y><T><A><K><M><I><H><Q><L><C><A><L><L><V><T><G><S><W><V><V><A><N><S><N><A><L><L><H><T><L><L><M><A><R><L><S><F><C><A><D><N><T><I><P><H><I><F><C><D><V><T><P><L><L><K><L><S><C><S><D><T><H><L><S><E><V><M><I><L><T><E><A><A><L><V><T><I><T><P><F><L><C><L><L><A><S><Y><M><H><I><T><C><V><V><L><R><V><P><S><T><K><G><R><W><K><A><F><S><T><C><G><S><H><L><A><V><V><L><L><F><Y><G><T><I><M><S><P><Y><F><R><T><S><S><S><H><S><A><Q><R><D><I><A><A><A><V><R><F><T><V><V><T><P><V><M><N><P><L><I><Y><S><L><R><N><K><D><I><K><G><A><L><V><K><V><V><A><V><K><F><F><S><V><Q> | Odorant receptor.<BOP> | Q96R84 |
Q8WU67 | ABHD3_HUMAN | Abhydrolase domain-containing protein 3 | Homo | <M><Q><R><L><A><M><D><L><R><M><L><S><R><E><L><S><L><Y><L><E><H><Q><V><R><V><G><F><F><G><S><G><V><G><L><S><L><I><L><G><F><S><V><A><Y><A><F><Y><Y><L><S><S><I><A><K><K><P><Q><L><V><T><G><G><E><S><F><S><R><F><L><Q><D><H><C><P><V><V><T><E><T><Y><Y><P><T><V><W><C><W><E><G><R><G><Q><T><L><L><R><P><F><I><T><S><K><P><P><V><Q><Y><R><N><E><L><I><K><T><A><D><G><G><Q><I><S><L><D><W><F><D><N><D><N><S><T><C><Y><M><D><A><S><T><R><P><T><I><L><L><L><P><G><L><T><G><T><S><K><E><S><Y><I><L><H><M><I><H><L><S><E><E><L><G><Y><R><C><V><V><F><N><N><R><G><V><A><G><E><N><L><L><T><P><R><T><Y><C><C><A><N><T><E><D><L><E><T><V><I><H><H><V><H><S><L><Y><P><S><A><P><F><L><A><A><G><V><S><M><G><G><M><L><L><L><N><Y><L><G><K><I><G><S><K><T><P><L><M><A><A><A><T><F><S><V><G><W><N><T><F><A><C><S><E><S><L><E><K><P><L><N><W><L><L><F><N><Y><Y><L><T><T><C><L><Q><S><S><V><N><K><H><R><H><M><F><V><K><Q><V><D><M><D><H><V><M><K><A><K><S><I><R><E><F><D><K><R><F><T><S><V><M><F><G><Y><Q><T><I><D><D><Y><Y><T><D><A><S><P><S><P><R><L><K><S><V><G><I><P><V><L><C><L><N><S><V><D><D><V><F><S><P><S><H><A><I><P><I><E><T><A><K><Q><N><P><N><V><A><L><V><L><T><S><Y><G><G><H><I><G><F><L><E><G><I><W><P><R><Q><S><T><Y><M><D><R><V><F><K><Q><F><V><Q><A><M><V><E><H><G><H><E><L><S> | Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.<BOP> | Q8WU67 |
Q13103 | SPP24_HUMAN | Secreted phosphoprotein 2 | Homo | <M><I><S><R><M><E><K><M><T><M><M><M><K><I><L><I><M><F><A><L><G><M><N><Y><W><S><C><S><G><F><P><V><Y><D><Y><D><P><S><S><L><R><D><A><L><S><A><S><V><V><K><V><N><S><Q><S><L><S><P><Y><L><F><R><A><F><R><S><S><L><K><R><V><E><V><L><D><E><N><N><L><V><M><N><L><E><F><S><I><R><E><T><T><C><R><K><D><S><G><E><D><P><A><T><C><A><F><Q><R><D><Y><Y><V><S><T><A><V><C><R><S><T><V><K><V><S><A><Q><Q><V><Q><G><V><H><A><R><C><S><W><S><S><S><T><S><E><S><Y><S><S><E><E><M><I><F><G><D><M><L><G><S><H><K><W><R><N><N><Y><L><F><G><L><I><S><D><E><S><I><S><E><Q><F><Y><D><R><S><L><G><I><M><R><R><V><L><P><P><G><N><R><R><Y><P><N><H><R><H><R><A><R><I><N><T><D><F><E> | Could coordinate an aspect of bone turnover.<BOP> | Q13103 |
P41247 | PLPL4_HUMAN | Protein GS2 | Homo | <M><K><H><I><N><L><S><F><A><A><C><G><F><L><G><I><Y><H><L><G><A><A><S><A><L><C><R><H><G><K><K><L><V><K><D><V><K><A><F><A><G><A><S><A><G><S><L><V><A><S><V><L><L><T><A><P><E><K><I><E><E><C><N><Q><F><T><Y><K><F><A><E><E><I><R><R><Q><S><F><G><A><V><T><P><G><Y><D><F><M><A><R><L><R><S><G><M><E><S><I><L><P><P><S><A><H><E><L><A><Q><N><R><L><H><V><S><I><T><N><A><K><T><R><E><N><H><L><V><S><T><F><S><S><R><E><D><L><I><K><V><L><L><A><S><S><F><V><P><I><Y><A><G><L><K><L><V><E><Y><K><G><Q><K><W><V><D><G><G><L><T><N><A><L><P><I><L><P><V><G><R><T><V><T><I><S><P><F><S><G><R><L><D><I><S><P><Q><D><K><G><Q><L><D><L><Y><V><N><I><A><K><Q><D><I><M><L><S><L><A><N><L><V><R><L><N><Q><A><L><F><P><P><S><K><R><K><M><E><S><L><Y><Q><C><G><F><D><D><T><V><K><F><L><L><K><E><N><W><F><E> | Has abundant triacylglycerol lipase activity . Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides . Additionally possesses acylglycerol transacylase and phospholipase A2 activities .<BOP> | P41247 |
A0A075B6I9 | LV746_HUMAN | Immunoglobulin lambda variable 7-46 | Homo | <M><A><W><T><P><L><F><L><F><L><L><T><C><C><P><G><S><N><S><Q><A><V><V><T><Q><E><P><S><L><T><V><S><P><G><G><T><V><T><L><T><C><G><S><S><T><G><A><V><T><S><G><H><Y><P><Y><W><F><Q><Q><K><P><G><Q><A><P><R><T><L><I><Y><D><T><S><N><K><H><S><W><T><P><A><R><F><S><G><S><L><L><G><G><K><A><A><L><T><L><L><G><A><Q><P><E><D><E><A><E><Y><Y><C><L><L><S><Y><S><G><A><R> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A075B6I9 |
Q96DF8 | ESS2_HUMAN | Protein ES2 | Homo | <M><E><T><P><G><A><S><A><S><S><L><L><L><P><A><A><S><R><P><P><R><K><R><E><A><G><E><A><G><A><A><T><S><K><Q><R><V><L><D><E><E><E><Y><I><E><G><L><Q><T><V><I><Q><R><D><F><F><P><D><V><E><K><L><Q><A><Q><K><E><Y><L><E><A><E><E><N><G><D><L><E><R><M><R><Q><I><A><I><K><F><G><S><A><L><G><K><M><S><R><E><P><P><P><P><Y><V><T><P><A><T><F><E><T><P><E><V><H><A><G><T><G><V><V><G><N><K><P><R><P><R><G><R><G><L><E><D><G><E><A><G><E><E><E><E><K><E><P><L><P><S><L><D><V><F><L><S><R><Y><T><S><E><D><N><A><S><F><Q><E><I><M><E><V><A><K><E><R><S><R><A><R><H><A><W><L><Y><Q><A><E><E><E><F><E><K><R><Q><K><D><N><L><E><L><P><S><A><E><H><Q><A><I><E><S><S><Q><A><S><V><E><T><W><K><Y><K><A><K><N><S><L><M><Y><Y><P><E><G><V><P><D><E><E><Q><L><F><K><K><P><R><Q><V><V><H><K><N><T><R><F><L><R><D><P><F><S><Q><A><L><S><R><C><Q><L><Q><Q><A><A><A><L><N><A><Q><H><K><Q><G><K><V><G><P><D><G><K><E><L><I><P><Q><E><S><P><R><V><G><G><F><G><F><V><A><T><P><S><P><A><P><G><V><N><E><S><P><M><M><T><W><G><E><V><E><N><T><P><L><R><V><E><G><S><E><T><P><Y><V><D><R><T><P><G><P><A><F><K><I><L><E><P><G><R><R><E><R><L><G><L><K><M><A><N><E><A><A><A><K><N><R><A><K><K><Q><E><A><L><R><R><V><T><E><N><L><A><S><L><T><P><K><G><L><S><P><A><M><S><P><A><L><Q><R><L><V><S><R><T><A><S><K><Y><T><D><R><A><L><R><A><S><Y><T><P><S><P><A><R><S><T><H><L><K><T><P><A><S><G><L><Q><T><P><T><S><T><P><A><P><G><S><A><T><R><T><P><L><T><Q><D><P><A><S><I><T><D><N><L><L><Q><L><P><A><R><R><K><A><S><D><F><F> | May be involved in pre-mRNA splicing.<BOP> | Q96DF8 |
Q9Y570 | PPME1_HUMAN | Protein phosphatase methylesterase 1 | Homo | <M><S><A><L><E><K><S><M><H><L><G><R><L><P><S><R><P><P><L><P><G><S><G><G><S><Q><S><G><A><K><M><R><M><G><P><G><R><K><R><D><F><S><P><V><P><W><S><Q><Y><F><E><S><M><E><D><V><E><V><E><N><E><T><G><K><D><T><F><R><V><Y><K><S><G><S><E><G><P><V><L><L><L><L><H><G><G><G><H><S><A><L><S><W><A><V><F><T><A><A><I><I><S><R><V><Q><C><R><I><V><A><L><D><L><R><S><H><G><E><T><K><V><K><N><P><E><D><L><S><A><E><T><M><A><K><D><V><G><N><V><V><E><A><M><Y><G><D><L><P><P><P><I><M><L><I><G><H><S><M><G><G><A><I><A><V><H><T><A><S><S><N><L><V><P><S><L><L><G><L><C><M><I><D><V><V><E><G><T><A><M><D><A><L><N><S><M><Q><N><F><L><R><G><R><P><K><T><F><K><S><L><E><N><A><I><E><W><S><V><K><S><G><Q><I><R><N><L><E><S><A><R><V><S><M><V><G><Q><V><K><Q><C><E><G><I><T><S><P><E><G><S><K><S><I><V><E><G><I><I><E><E><E><E><E><D><E><E><G><S><E><S><I><S><K><R><K><K><E><D><D><M><E><T><K><K><D><H><P><Y><T><W><R><I><E><L><A><K><T><E><K><Y><W><D><G><W><F><R><G><L><S><N><L><F><L><S><C><P><I><P><K><L><L><L><L><A><G><V><D><R><L><D><K><D><L><T><I><G><Q><M><Q><G><K><F><Q><M><Q><V><L><P><Q><C><G><H><A><V><H><E><D><A><P><D><K><V><A><E><A><V><A><T><F><L><I><R><H><R><F><A><E><P><I><G><G><F><Q><C><V><F><P><G><C> | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.<BOP> | Q9Y570 |
Q13356 | PPIL2_HUMAN | Rotamase PPIL2 | Homo | <M><G><K><R><Q><H><Q><K><D><K><M><Y><I><T><C><A><E><Y><T><H><F><Y><G><G><K><K><P><D><L><P><Q><T><N><F><R><R><L><P><F><D><H><C><S><L><S><L><Q><P><F><V><Y><P><V><C><T><P><D><G><I><V><F><D><L><L><N><I><V><P><W><L><K><K><Y><G><T><N><P><S><N><G><E><K><L><D><G><R><S><L><I><K><L><N><F><S><K><N><S><E><G><K><Y><H><C><P><V><L><F><T><V><F><T><N><N><T><H><I><V><A><V><R><T><T><G><N><V><Y><A><Y><E><A><V><E><Q><L><N><I><K><A><K><N><F><R><D><L><L><T><D><E><P><F><S><R><Q><D><I><I><T><L><Q><D><P><T><N><L><D><K><F><N><V><S><N><F><Y><H><V><K><N><N><M><K><I><I><D><P><D><E><E><K><A><K><Q><D><P><S><Y><Y><L><K><N><T><N><A><E><T><R><E><T><L><Q><E><L><Y><K><E><F><K><G><D><E><I><L><A><A><T><M><K><A><P><E><K><K><K><V><D><K><L><N><A><A><H><Y><S><T><G><K><V><S><A><S><F><T><S><T><A><M><V><P><E><T><T><H><E><A><A><A><I><D><E><D><V><L><R><Y><Q><F><V><K><K><K><G><Y><V><R><L><H><T><N><K><G><D><L><N><L><E><L><H><C><D><L><T><P><K><T><C><E><N><F><I><R><L><C><K><K><H><Y><Y><D><G><T><I><F><H><R><S><I><R><N><F><V><I><Q><G><G><D><P><T><G><T><G><T><G><G><E><S><Y><W><G><K><P><F><K><D><E><F><R><P><N><L><S><H><T><G><R><G><I><L><S><M><A><N><S><G><P><N><S><N><R><S><Q><F><F><I><T><F><R><S><C><A><Y><L><D><K><K><H><T><I><F><G><R><V><V><G><G><F><D><V><L><T><A><M><E><N><V><E><S><D><P><K><T><D><R><P><K><E><E><I><R><I><D><A><T><T><V><F><V><D><P><Y><E><E><A><D><A><Q><I><A><Q><E><R><K><T><Q><L><K><V><A><P><E><T><K><V><K><S><S><Q><P><Q><A><G><S><Q><G><P><Q><T><F><R><Q><G><V><G><K><Y><I><N><P><A><A><T><K><R><A><A><E><E><E><P><S><T><S><A><T><V><P><M><S><K><K><K><P><S><R><G><F><G><D><F><S><S><W> | Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation . May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance . Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity .<BOP> | Q13356 |
Q9H3G5 | CPVL_HUMAN | Vitellogenic carboxypeptidase-like protein | Homo | <M><V><G><A><M><W><K><V><I><V><S><L><V><L><L><M><P><G><P><C><D><G><L><F><R><S><L><Y><R><S><V><S><M><P><P><K><G><D><S><G><Q><P><L><F><L><T><P><Y><I><E><A><G><K><I><Q><K><G><R><E><L><S><L><V><G><P><F><P><G><L><N><M><K><S><Y><A><G><F><L><T><V><N><K><T><Y><N><S><N><L><F><F><W><F><F><P><A><Q><I><Q><P><E><D><A><P><V><V><L><W><L><Q><G><G><P><G><G><S><S><M><F><G><L><F><V><E><H><G><P><Y><V><V><T><S><N><M><T><L><R><D><R><D><F><P><W><T><T><T><L><S><M><L><Y><I><D><N><P><V><G><T><G><F><S><F><T><D><D><T><H><G><Y><A><V><N><E><D><D><V><A><R><D><L><Y><S><A><L><I><Q><F><F><Q><I><F><P><E><Y><K><N><N><D><F><Y><V><T><G><E><S><Y><A><G><K><Y><V><P><A><I><A><H><L><I><H><S><L><N><P><V><R><E><V><K><I><N><L><N><G><I><A><I><G><D><G><Y><S><D><P><E><S><I><I><G><G><Y><A><E><F><L><Y><Q><I><G><L><L><D><E><K><Q><K><K><Y><F><Q><K><Q><C><H><E><C><I><E><H><I><R><K><Q><N><W><F><E><A><F><E><I><L><D><K><L><L><D><G><D><L><T><S><D><P><S><Y><F><Q><N><V><T><G><C><S><N><Y><Y><N><F><L><R><C><T><E><P><E><D><Q><L><Y><Y><V><K><F><L><S><L><P><E><V><R><Q><A><I><H><V><G><N><Q><T><F><N><D><G><T><I><V><E><K><Y><L><R><E><D><T><V><Q><S><V><K><P><W><L><T><E><I><M><N><N><Y><K><V><L><I><Y><N><G><Q><L><D><I><I><V><A><A><A><L><T><E><R><S><L><M><G><M><D><W><K><G><S><Q><E><Y><K><K><A><E><K><K><V><W><K><I><F><K><S><D><S><E><V><A><G><Y><I><R><Q><A><G><D><F><H><Q><V><I><I><R><G><G><G><H><I><L><P><Y><D><Q><P><L><R><A><F><D><M><I><N><R><F><I><Y><G><K><G><W><D><P><Y><V><G> | May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.<BOP> | Q9H3G5 |
P19235 | EPOR_HUMAN | Erythropoietin receptor | Homo | <M><D><H><L><G><A><S><L><W><P><Q><V><G><S><L><C><L><L><L><A><G><A><A><W><A><P><P><P><N><L><P><D><P><K><F><E><S><K><A><A><L><L><A><A><R><G><P><E><E><L><L><C><F><T><E><R><L><E><D><L><V><C><F><W><E><E><A><A><S><A><G><V><G><P><G><N><Y><S><F><S><Y><Q><L><E><D><E><P><W><K><L><C><R><L><H><Q><A><P><T><A><R><G><A><V><R><F><W><C><S><L><P><T><A><D><T><S><S><F><V><P><L><E><L><R><V><T><A><A><S><G><A><P><R><Y><H><R><V><I><H><I><N><E><V><V><L><L><D><A><P><V><G><L><V><A><R><L><A><D><E><S><G><H><V><V><L><R><W><L><P><P><P><E><T><P><M><T><S><H><I><R><Y><E><V><D><V><S><A><G><N><G><A><G><S><V><Q><R><V><E><I><L><E><G><R><T><E><C><V><L><S><N><L><R><G><R><T><R><Y><T><F><A><V><R><A><R><M><A><E><P><S><F><G><G><F><W><S><A><W><S><E><P><V><S><L><L><T><P><S><D><L><D><P><L><I><L><T><L><S><L><I><L><V><V><I><L><V><L><L><T><V><L><A><L><L><S><H><R><R><A><L><K><Q><K><I><W><P><G><I><P><S><P><E><S><E><F><E><G><L><F><T><T><H><K><G><N><F><Q><L><W><L><Y><Q><N><D><G><C><L><W><W><S><P><C><T><P><F><T><E><D><P><P><A><S><L><E><V><L><S><E><R><C><W><G><T><M><Q><A><V><E><P><G><T><D><D><E><G><P><L><L><E><P><V><G><S><E><H><A><Q><D><T><Y><L><V><L><D><K><W><L><L><P><R><N><P><P><S><E><D><L><P><G><P><G><G><S><V><D><I><V><A><M><D><E><G><S><E><A><S><S><C><S><S><A><L><A><S><K><P><S><P><E><G><A><S><A><A><S><F><E><Y><T><I><L><D><P><S><S><Q><L><L><R><P><W><T><L><C><P><E><L><P><P><T><P><P><H><L><K><Y><L><Y><L><V><V><S><D><S><G><I><S><T><D><Y><S><S><G><D><S><Q><G><A><Q><G><G><L><S><D><G><P><Y><S><N><P><Y><E><N><S><L><I><P><A><A><E><P><L><P><P><S><Y><V><A><C><S> | Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.<BOP> | P19235 |
Q12988 | HSPB3_HUMAN | Protein 3 | Homo | <M><A><K><I><I><L><R><H><L><I><E><I><P><V><R><Y><Q><E><E><F><E><A><R><G><L><E><D><C><R><L><D><H><A><L><Y><A><L><P><G><P><T><I><V><D><L><R><K><T><R><A><A><Q><S><P><P><V><D><S><A><A><E><T><P><P><R><E><G><K><S><H><F><Q><I><L><L><D><V><V><Q><F><L><P><E><D><I><I><I><Q><T><F><E><G><W><L><L><I><K><A><Q><H><G><T><R><M><D><E><H><G><F><I><S><R><S><F><T><R><Q><Y><K><L><P><D><G><V><E><I><K><D><L><S><A><V><L><C><H><D><G><I><L><V><V><E><V><K><D><P><V><G><T><K> | Inhibitor of actin polymerization.<BOP> | Q12988 |
Q9BZJ3 | TRYD_HUMAN | Tryptase-3 | Homo | <M><L><L><L><A><P><Q><M><L><S><L><L><L><L><A><L><P><V><L><A><S><P><A><Y><V><A><P><A><P><G><Q><A><L><Q><Q><T><G><I><V><G><G><Q><E><A><P><R><S><K><W><P><W><Q><V><S><L><R><V><R><G><P><Y><W><M><H><F><C><G><G><S><L><I><H><P><Q><W><V><L><T><A><A><H><C><V><E><P><D><I><K><D><L><A><A><L><R><V><Q><L><R><E><Q><H><L><Y><Y><Q><D><Q><L><L><P><V><S><R><I><I><V><H><P><Q><F><Y><I><I><Q><T><G><A><D><I><A><L><L><E><L><E><E><P><V><N><I><S><S><H><I><H><T><V><T><L><P><P><A><S><E><T><F><P><P><G><M><P><C><W><V><T><G><W><G><D><V><D><N><N><V><H><L><P><P><P><Y><P><L><K><E><V><E><V><P><V><V><E><N><H><L><C><N><A><E><Y><H><T><G><L><H><T><G><H><S><F><Q><I><V><R><D><D><M><L><C><A><G><S><E><N><H><D><S><C><Q><G><D><S><G><G><P><L><V><C><K><V><N><G><T> | Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.<BOP> | Q9BZJ3 |
Q9UI46 | DNAI1_HUMAN | Axonemal dynein intermediate chain 1 | Homo | <M><I><P><A><S><A><K><A><P><H><K><Q><P><H><K><Q><S><I><S><I><G><R><G><T><R><K><R><D><E><D><S><G><T><E><V><G><E><G><T><D><E><W><A><Q><S><K><A><T><V><R><P><P><D><Q><L><E><L><T><D><A><E><L><K><E><E><F><T><R><I><L><T><A><N><N><P><H><A><P><Q><N><I><V><R><Y><S><F><K><E><G><T><Y><K><P><I><G><F><V><N><Q><L><A><V><H><Y><T><Q><V><G><N><L><I><P><K><D><S><D><E><G><R><R><Q><H><Y><R><D><E><L><V><A><G><S><Q><E><S><V><K><V><I><S><E><T><G><N><L><E><E><D><E><E><P><K><E><L><E><T><E><P><G><S><Q><T><D><V><P><A><A><G><A><A><E><K><V><T><E><E><E><L><M><T><P><K><Q><P><K><E><R><K><L><T><N><Q><F><N><F><S><E><R><A><S><Q><T><Y><N><N><P><V><R><D><R><E><C><Q><T><E><P><P><P><R><T><N><F><S><A><T><A><N><Q><W><E><I><Y><D><A><Y><V><E><E><L><E><K><Q><E><K><T><K><E><K><E><K><A><K><T><P><V><A><K><K><S><G><K><M><A><M><R><K><L><T><S><M><E><S><Q><T><D><D><L><I><K><L><S><Q><A><A><K><I><M><E><R><M><V><N><Q><N><T><Y><D><D><I><A><Q><D><F><K><Y><Y><D><D><A><A><D><E><Y><R><D><Q><V><G><T><L><L><P><L><W><K><F><Q><N><D><K><A><K><R><L><S><V><T><A><L><C><W><N><P><K><Y><R><D><L><F><A><V><G><Y><G><S><Y><D><F><M><K><Q><S><R><G><M><L><L><L><Y><S><L><K><N><P><S><F><P><E><Y><M><F><S><S><N><S><G><V><M><C><L><D><I><H><V><D><H><P><Y><L><V><A><V><G><H><Y><D><G><N><V><A><I><Y><N><L><K><K><P><H><S><Q><P><S><F><C><S><S><A><K><S><G><K><H><S><D><P><V><W><Q><V><K><W><Q><K><D><D><M><D><Q><N><L><N><F><F><S><V><S><S><D><G><R><I><V><S><W><T><L><V><K><R><K><L><V><H><I><D><V><I><K><L><K><V><E><G><S><T><T><E><V><P><E><G><L><Q><L><H><P><V><G><C><G><T><A><F><D><F><H><K><E><I><D><Y><M><F><L><V><G><T><E><E><G><K><I><Y><K><C><S><K><S><Y><S><S><Q><F><L><D><T><Y><D><A><H><N><M><S><V><D><T><V><S><W><N><P><Y><H><T><K><V><F><M><S><C><S><S><D><W><T><V><K><I><W><D><H><T><I><K><T><P><M><F><I><Y><D><L><N><S><A><V><G><D><V><A><W><A><P><Y><S><S><T><V><F><A><A><V><T><T><D><G><K><A><H><I><F><D><L><A><I><N><K><Y><E><A><I><C><N><Q><P><V><A><A><K><K><N><R><L><T><H><V><Q><F><N><L><I><H><P><I><I><I><V><G><D><D><R><G><H><I><I><S><L><K><L><S><P><N><L><R><K><M><P><K><E><K><K><G><Q><E><V><Q><K><G><P><A><V><E><I><A><K><L><D><K><L><L><N><L><V><R><E><V><K><I><K><T> | Part of the dynein complex of respiratory cilia.<BOP> | Q9UI46 |
Q99081 | HTF4_HUMAN | Transcription factor HTF-4 | Homo | <M><N><P><Q><Q><Q><R><M><A><A><I><G><T><D><K><E><L><S><D><L><L><D><F><S><A><M><F><S><P><P><V><N><S><G><K><T><R><P><T><T><L><G><S><S><Q><F><S><G><S><G><I><D><E><R><G><G><T><T><S><W><G><T><S><G><Q><P><S><P><S><Y><D><S><S><R><G><F><T><D><S><P><H><Y><S><D><H><L><N><D><S><R><L><G><A><H><E><G><L><S><P><T><P><F><M><N><S><N><L><M><G><K><T><S><E><R><G><S><F><S><L><Y><S><R><D><T><G><L><P><G><C><Q><S><S><L><L><R><Q><D><L><G><L><G><S><P><A><Q><L><S><S><S><G><K><P><G><T><A><Y><Y><S><F><S><A><T><S><S><R><R><R><P><L><H><D><S><A><A><L><D><P><L><Q><A><K><K><V><R><K><V><P><P><G><L><P><S><S><V><Y><A><P><S><P><N><S><D><D><F><N><R><E><S><P><S><Y><P><S><P><K><P><P><T><S><M><F><A><S><T><F><F><M><Q><D><G><T><H><N><S><S><D><L><W><S><S><S><N><G><M><S><Q><P><G><F><G><G><I><L><G><T><S><T><S><H><M><S><Q><S><S><S><Y><G><N><L><H><S><H><D><R><L><S><Y><P><P><H><S><V><S><P><T><D><I><N><T><S><L><P><P><M><S><S><F><H><R><G><S><T><S><S><S><P><Y><V><A><A><S><H><T><P><P><I><N><G><S><D><S><I><L><G><T><R><G><N><A><A><G><S><S><Q><T><G><D><A><L><G><K><A><L><A><S><I><Y><S><P><D><H><T><S><S><S><F><P><S><N><P><S><T><P><V><G><S><P><S><P><L><T><G><T><S><Q><W><P><R><P><G><G><Q><A><P><S><S><P><S><Y><E><N><S><L><H><S><L><Q><S><R><M><E><D><R><L><D><R><L><D><D><A><I><H><V><L><R><N><H><A><V><G><P><S><T><S><L><P><A><G><H><S><D><I><H><S><L><L><G><P><S><H><N><A><P><I><G><S><L><N><S><N><Y><G><G><S><S><L><V><A><S><S><R><S><A><S><M><V><G><T><H><R><E><D><S><V><S><L><N><G><N><H><S><V><L><S><S><T><V><T><T><S><S><T><D><L><N><H><K><T><Q><E><N><Y><R><G><G><L><Q><S><Q><S><G><T><V><V><T><T><E><I><K><T><E><N><K><E><K><D><E><N><L><H><E><P><P><S><S><D><D><M><K><S><D><D><E><S><S><Q><K><D><I><K><V><S><S><R><G><R><T><S><S><T><N><E><D><E><D><L><N><P><E><Q><K><I><E><R><E><K><E><R><R><M><A><N><N><A><R><E><R><L><R><V><R><D><I><N><E><A><F><K><E><L><G><R><M><C><Q><L><H><L><K><S><E><K><P><Q><T><K><L><L><I><L><H><Q><A><V><A><V><I><L><S><L><E><Q><Q><V><R><E><R><N><L><N><P><K><A><A><C><L><K><R><R><E><E><E><K><V><S><A><V><S><A><E><P><P><T><T><L><P><G><T><H><P><G><L><S><E><T><T><N><P><M><G><H><M> | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').<BOP> | Q99081 |
Q7L5Y6 | DET1_HUMAN | De-etiolated-1 homolog | Homo | <M><D><H><H><V><S><T><I><K><P><R><R><I><Q><N><Q><N><V><I><H><R><L><E><R><R><R><I><S><S><G><K><A><G><T><H><W><H><Q><V><R><V><F><H><Q><N><V><F><P><N><F><T><V><V><N><V><E><K><P><P><C><F><L><R><K><F><S><P><D><G><R><Y><F><I><A><F><S><S><D><Q><T><S><L><E><I><Y><E><Y><Q><G><C><Q><A><A><E><D><L><L><Q><G><Y><E><G><E><I><L><S><N><G><N><D><Q><R><S><V><N><I><R><G><R><L><F><E><R><F><F><V><L><L><H><I><T><N><V><A><A><N><G><E><H><L><N><R><E><C><S><L><F><T><D><D><C><R><C><V><I><V><G><S><A><A><Y><L><P><D><E><P><H><P><P><F><F><E><V><Y><R><N><S><E><S><V><T><P><N><P><R><S><P><L><E><D><Y><S><L><H><I><I><D><L><H><T><G><R><L><C><D><T><R><T><F><K><C><D><K><V><V><L><S><H><N><Q><G><L><Y><L><Y><K><N><I><L><A><I><L><S><V><Q><Q><Q><T><I><H><V><F><Q><V><T><P><E><G><T><F><I><D><V><R><T><I><G><R><F><C><Y><E><D><D><L><L><T><V><S><A><V><F><P><E><V><Q><R><D><S><Q><T><G><M><A><N><P><F><R><D><P><F><I><N><S><L><K><H><R><L><L><V><Y><L><W><R><R><A><E><Q><D><G><S><A><M><A><K><R><R><F><F><Q><Y><F><D><Q><L><R><Q><L><R><M><W><K><M><Q><L><L><D><E><N><H><L><F><I><K><Y><T><S><E><D><V><V><T><L><R><V><T><D><P><S><Q><A><S><F><F><V><V><Y><N><M><V><T><T><E><V><I><A><V><F><E><N><T><S><D><E><L><L><E><L><F><E><N><F><C><D><L><F><R><N><A><T><L><H><S><E><V><Q><F><P><C><S><A><S><S><N><N><F><A><R><Q><I><Q><R><R><F><K><D><T><I><I><N><A><K><Y><G><G><H><T><E><A><V><R><R><L><L><G><Q><L><P><I><S><A><Q><S><Y><S><G><S><P><Y><L><D><L><S><L><F><S><Y><D><D><K><W><V><S><V><M><E><R><P><K><T><C><G><D><H><P><I><R><F><Y><A><R><D><S><G><L><L><K><F><E><I><Q><A><G><L><L><G><R><P><I><N><H><T><V><R><R><L><V><A><F><T><F><H><P><F><E><P><F><A><I><S><V><Q><R><T><N><A><E><Y><V><V><N><F><H><M><R><H><C><C><T> | Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.<BOP> | Q7L5Y6 |
Q9H461 | FZD8_HUMAN | Frizzled-8 | Homo | <M><E><W><G><Y><L><L><E><V><T><S><L><L><A><A><L><A><L><L><Q><R><S><S><G><A><A><A><A><S><A><K><E><L><A><C><Q><E><I><T><V><P><L><C><K><G><I><G><Y><N><Y><T><Y><M><P><N><Q><F><N><H><D><T><Q><D><E><A><G><L><E><V><H><Q><F><W><P><L><V><E><I><Q><C><S><P><D><L><K><F><F><L><C><S><M><Y><T><P><I><C><L><E><D><Y><K><K><P><L><P><P><C><R><S><V><C><E><R><A><K><A><G><C><A><P><L><M><R><Q><Y><G><F><A><W><P><D><R><M><R><C><D><R><L><P><E><Q><G><N><P><D><T><L><C><M><D><Y><N><R><T><D><L><T><T><A><A><P><S><P><P><R><R><L><P><P><P><P><P><G><E><Q><P><P><S><G><S><G><H><G><R><P><P><G><A><R><P><P><H><R><G><G><G><R><G><G><G><G><G><D><A><A><A><P><P><A><R><G><G><G><G><G><G><K><A><R><P><P><G><G><G><A><A><P><C><E><P><G><C><Q><C><R><A><P><M><V><S><V><S><S><E><R><H><P><L><Y><N><R><V><K><T><G><Q><I><A><N><C><A><L><P><C><H><N><P><F><F><S><Q><D><E><R><A><F><T><V><F><W><I><G><L><W><S><V><L><C><F><V><S><T><F><A><T><V><S><T><F><L><I><D><M><E><R><F><K><Y><P><E><R><P><I><I><F><L><S><A><C><Y><L><F><V><S><V><G><Y><L><V><R><L><V><A><G><H><E><K><V><A><C><S><G><G><A><P><G><A><G><G><A><G><G><A><G><G><A><A><A><G><A><G><A><A><G><A><G><A><G><G><P><G><G><R><G><E><Y><E><E><L><G><A><V><E><Q><H><V><R><Y><E><T><T><G><P><A><L><C><T><V><V><F><L><L><V><Y><F><F><G><M><A><S><S><I><W><W><V><I><L><S><L><T><W><F><L><A><A><G><M><K><W><G><N><E><A><I><A><G><Y><S><Q><Y><F><H><L><A><A><W><L><V><P><S><V><K><S><I><A><V><L><A><L><S><S><V><D><G><D><P><V><A><G><I><C><Y><V><G><N><Q><S><L><D><N><L><R><G><F><V><L><A><P><L><V><I><Y><L><F><I><G><T><M><F><L><L><A><G><F><V><S><L><F><R><I><R><S><V><I><K><Q><Q><D><G><P><T><K><T><H><K><L><E><K><L><M><I><R><L><G><L><F><T><V><L><Y><T><V><P><A><A><V><V><V><A><C><L><F><Y><E><Q><H><N><R><P><R><W><E><A><T><H><N><C><P><C><L><R><D><L><Q><P><D><Q><A><R><R><P><D><Y><A><V><F><M><L><K><Y><F><M><C><L><V><V><G><I><T><S><G><V><W><V><W><S><G><K><T><L><E><S><W><R><S><L><C><T><R><C><C><W><A><S><K><G><A><A><V><G><G><G><A><G><A><T><A><A><G><G><G><G><G><P><G><G><G><G><G><G><G><P><G><G><G><G><G><P><G><G><G><G><G><S><L><Y><S><D><V><S><T><G><L><T><W><R><S><G><T><A><S><S><V><S><Y><P><K><Q><M><P><L><S><Q><V> | Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.<BOP> | Q9H461 |
O14960 | LECT2_HUMAN | Leukocyte cell-derived chemotaxin-2 | Homo | <M><F><S><T><K><A><L><L><L><A><G><L><I><S><T><A><L><A><G><P><W><A><N><I><C><A><G><K><S><S><N><E><I><R><T><C><D><R><H><G><C><G><Q><Y><S><A><Q><R><S><Q><R><P><H><Q><G><V><D><I><L><C><S><A><G><S><T><V><Y><A><P><F><T><G><M><I><V><G><Q><E><K><P><Y><Q><N><K><N><A><I><N><N><G><V><R><I><S><G><R><G><F><C><V><K><M><F><Y><I><K><P><I><K><Y><K><G><P><I><K><K><G><E><K><L><G><T><L><L><P><L><Q><K><V><Y><P><G><I><Q><S><H><V><H><I><E><N><C><D><S><S><D><P><T><A><Y><L> | Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation . Does not show metalloendopeptidase activity .<BOP> | O14960 |
Q15116 | PDCD1_HUMAN | Programmed cell death protein 1 | Homo | <M><Q><I><P><Q><A><P><W><P><V><V><W><A><V><L><Q><L><G><W><R><P><G><W><F><L><D><S><P><D><R><P><W><N><P><P><T><F><S><P><A><L><L><V><V><T><E><G><D><N><A><T><F><T><C><S><F><S><N><T><S><E><S><F><V><L><N><W><Y><R><M><S><P><S><N><Q><T><D><K><L><A><A><F><P><E><D><R><S><Q><P><G><Q><D><C><R><F><R><V><T><Q><L><P><N><G><R><D><F><H><M><S><V><V><R><A><R><R><N><D><S><G><T><Y><L><C><G><A><I><S><L><A><P><K><A><Q><I><K><E><S><L><R><A><E><L><R><V><T><E><R><R><A><E><V><P><T><A><H><P><S><P><S><P><R><P><A><G><Q><F><Q><T><L><V><V><G><V><V><G><G><L><L><G><S><L><V><L><L><V><W><V><L><A><V><I><C><S><R><A><A><R><G><T><I><G><A><R><R><T><G><Q><P><L><K><E><D><P><S><A><V><P><V><F><S><V><D><Y><G><E><L><D><F><Q><W><R><E><K><T><P><E><P><P><V><P><C><V><P><E><Q><T><E><Y><A><T><I><V><F><P><S><G><M><G><T><S><S><P><A><R><R><G><S><A><D><G><P><R><S><A><Q><P><L><R><P><E><D><G><H><C><S><W><P><L> | The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival . The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function . The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy .<BOP> | Q15116 |
Q8WVE0 | EFMT1_HUMAN | eEF1A-KMT | Homo | <M><S><D><L><E><D><D><E><T><P><Q><L><S><A><H><A><L><A><A><L><Q><E><F><Y><A><E><Q><K><Q><Q><I><E><P><G><E><D><D><K><Y><N><I><G><I><I><E><E><N><W><Q><L><S><Q><F><W><Y><S><Q><E><T><A><L><Q><L><A><Q><E><A><I><A><A><V><G><E><G><G><R><I><A><C><V><S><A><P><S><V><Y><Q><K><L><R><E><L><C><R><E><N><F><S><I><Y><I><F><E><Y><D><K><R><F><A><M><Y><G><E><E><F><I><F><Y><D><Y><N><N><P><L><D><L><P><E><R><I><A><A><H><S><F><D><I><V><I><A><D><P><P><Y><L><S><E><E><C><L><R><K><T><S><E><T><V><K><Y><L><T><R><G><K><I><L><L><C><T><G><A><I><M><E><E><Q><A><A><E><L><L><G><V><K><M><C><T><F><V><P><R><H><T><R><N><L><A><N><E><F><R><C><Y><V><N><Y><D><S><G><L><D><C><G><I> | Protein N-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.<BOP> | Q8WVE0 |
Q3LI60 | KR203_HUMAN | Keratin-associated protein 20-3 | Homo | <M><S><Y><Y><G><N><Y><Y><G><G><L><G><Y><G><Y><D><C><K><Y><S><Y><T><S><G><F><G><A><F><R><I><L><D><C><G><Y><R><C><G><C><G><G><V><W><I> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q3LI60 |
O43566 | RGS14_HUMAN | Regulator of G-protein signaling 14 | Homo | <M><P><G><K><P><K><H><L><G><V><P><N><G><R><M><V><L><A><V><S><D><G><E><L><S><S><T><T><G><P><Q><G><Q><G><E><G><R><G><S><S><L><S><I><H><S><L><P><S><G><P><S><S><P><F><P><T><E><E><Q><P><V><A><S><W><A><L><S><F><E><R><L><L><Q><D><P><L><G><L><A><Y><F><T><E><F><L><K><K><E><F><S><A><E><N><V><T><F><W><K><A><C><E><R><F><Q><Q><I><P><A><S><D><T><Q><Q><L><A><Q><E><A><R><N><I><Y><Q><E><F><L><S><S><Q><A><L><S><P><V><N><I><D><R><Q><A><W><L><G><E><E><V><L><A><E><P><R><P><D><M><F><R><A><Q><Q><L><Q><I><F><N><L><M><K><F><D><S><Y><A><R><F><V><K><S><P><L><Y><R><E><C><L><L><A><E><A><E><G><R><P><L><R><E><P><G><S><S><R><L><G><S><P><D><A><T><R><K><K><P><K><L><K><P><G><K><S><L><P><L><G><V><E><E><L><G><Q><L><P><P><V><E><G><P><G><G><R><P><L><R><K><S><F><R><R><E><L><G><G><T><A><N><A><A><L><R><R><E><S><Q><G><S><L><N><S><S><A><S><L><D><L><G><F><L><A><F><V><S><S><K><S><E><S><H><R><K><S><L><G><S><T><E><G><E><S><E><S><R><P><G><K><Y><C><C><V><Y><L><P><D><G><T><A><S><L><A><L><A><R><P><G><L><T><I><R><D><M><L><A><G><I><C><E><K><R><G><L><S><L><P><D><I><K><V><Y><L><V><G><N><E><Q><A><L><V><L><D><Q><D><C><T><V><L><A><D><Q><E><V><R><L><E><N><R><I><T><F><E><L><E><L><T><A><L><E><R><V><V><R><I><S><A><K><P><T><K><R><L><Q><E><A><L><Q><P><I><L><E><K><H><G><L><S><P><L><E><V><V><L><H><R><P><G><E><K><Q><P><L><D><L><G><K><L><V><S><S><V><A><A><Q><R><L><V><L><D><T><L><P><G><V><K><I><S><K><A><R><D><K><S><P><C><R><S><Q><G><C><P><P><R><T><Q><D><K><A><T><H><P><P><P><A><S><P><S><S><L><V><K><V><P><S><S><A><T><G><K><R><Q><T><C><D><I><E><G><L><V><E><L><L><N><R><V><Q><S><S><G><A><H><D><Q><R><G><L><L><R><K><E><D><L><V><L><P><E><F><L><Q><L><P><A><Q><G><P><S><S><E><E><T><P><P><Q><T><K><S><A><A><Q><P><I><G><G><S><L><N><S><T><T><D><S><A><L> | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory | O43566 |
Q5T440 | CAF17_HUMAN | Iron-sulfur cluster assembly factor homolog | Homo | <M><A><T><A><A><L><L><R><G><A><T><P><G><R><G><G><P><V><W><R><W><R><L><R><A><A><P><R><C><R><L><A><H><S><S><C><S><P><G><G><D><P><T><A><G><A><A><W><A><C><F><R><L><D><G><R><T><L><L><R><V><R><G><P><D><A><A><P><F><L><L><G><L><L><T><N><E><L><P><L><P><S><P><A><A><A><G><A><P><P><A><A><R><A><G><Y><A><H><F><L><N><V><Q><G><R><T><L><Y><D><V><I><L><Y><G><L><Q><E><H><S><E><V><S><G><F><L><L><E><C><D><S><S><V><Q><G><A><L><Q><K><H><L><A><L><Y><R><I><R><R><K><V><T><V><E><P><H><P><E><L><R><V><W><A><V><L><P><S><S><P><E><A><C><G><A><A><S><L><Q><E><R><A><G><A><A><A><I><L><I><R><D><P><R><T><A><R><M><G><W><R><L><L><T><Q><D><E><G><P><A><L><V><P><G><G><R><L><G><D><L><W><D><Y><H><Q><H><R><Y><L><Q><G><V><P><E><G><V><R><D><L><P><P><G><V><A><L><P><L><E><S><N><L><A><F><M><N><G><V><S><F><T><K><G><C><Y><I><G><Q><E><L><T><A><R><T><H><H><M><G><V><I><R><K><R><L><F><P><V><R><F><L><D><P><L><P><T><S><G><I><T><P><G><A><T><V><L><T><A><S><G><Q><T><V><G><K><F><R><A><G><Q><G><N><V><G><L><A><L><L><W><S><E><K><I><K><G><P><L><H><I><R><A><S><E><G><A><Q><V><A><L><A><A><S><V><P><D><W><W><P><T><V><S><K> | Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway.<BOP> | Q5T440 |
Q96HA8 | NTAQ1_HUMAN | WDYHV motif-containing protein 1 | Homo | <M><E><G><N><G><P><A><A><V><H><Y><Q><P><A><S><P><P><R><D><A><C><V><Y><S><S><C><Y><C><E><E><N><I><W><K><L><C><E><Y><I><K><N><H><D><Q><Y><P><L><E><E><C><Y><A><V><F><I><S><N><E><R><K><M><I><P><I><W><K><Q><Q><A><R><P><G><D><G><P><V><I><W><D><Y><H><V><V><L><L><H><V><S><S><G><G><Q><N><F><I><Y><D><L><D><T><V><L><P><F><P><C><L><F><D><T><Y><V><E><D><A><F><K><S><D><D><D><I><H><P><Q><F><R><R><K><F><R><V><I><R><A><D><S><Y><L><K><N><F><A><S><D><R><S><H><M><K><D><S><S><G><N><W><R><E><P><P><P><P><Y><P><C><I><E><T><G><D><S><K><M><N><L><N><D><F><I><S><M><D><P><K><V><G><W><G><A><V><Y><T><L><S><E><F><T><H><R><F><G><S><K><N><C> | Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.<BOP> | Q96HA8 |
Q9H115 | SNAB_HUMAN | N-ethylmaleimide-sensitive factor attachment protein beta | Homo | <M><D><N><A><G><K><E><R><E><A><V><Q><L><M><A><E><A><E><K><R><V><K><A><S><H><S><F><L><R><G><L><F><G><G><N><T><R><I><E><E><A><C><E><M><Y><T><R><A><A><N><M><F><K><M><A><K><N><W><S><A><A><G><N><A><F><C><Q><A><A><K><L><H><M><Q><L><Q><S><K><H><D><S><A><T><S><F><V><D><A><G><N><A><Y><K><K><A><D><P><Q><E><A><I><N><C><L><N><A><A><I><D><I><Y><T><D><M><G><R><F><T><I><A><A><K><H><H><I><T><I><A><E><I><Y><E><T><E><L><V><D><I><E><K><A><I><A><H><Y><E><Q><S><A><D><Y><Y><K><G><E><E><S><N><S><S><A><N><K><C><L><L><K><V><A><A><Y><A><A><Q><L><E><Q><Y><Q><K><A><I><E><I><Y><E><Q><V><G><A><N><T><M><D><N><P><L><L><K><Y><S><A><K><D><Y><F><F><K><A><A><L><C><H><F><I><V><D><E><L><N><A><K><L><A><L><E><K><Y><E><E><M><F><P><A><F><T><D><S><R><E><C><K><L><L><K><K><L><L><E><A><H><E><E><Q><N><S><E><A><Y><T><E><A><V><K><E><F><D><S><I><S><R><L><D><Q><W><L><T><T><M><L><L><R><I><K><K><S><I><Q><G><D><G><E><G><D><G><D><L><K> | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.<BOP> | Q9H115 |
Q02833 | RASF7_HUMAN | HRAS1-related cluster protein 1 | Homo | <M><L><L><G><L><A><A><M><E><L><K><V><W><V><D><G><I><Q><R><V><V><C><G><V><S><E><Q><T><T><C><Q><E><V><V><I><A><L><A><Q><A><I><G><Q><T><G><R><F><V><L><V><Q><R><L><R><E><K><E><R><Q><L><L><P><Q><E><C><P><V><G><A><Q><A><T><C><G><Q><F><A><S><D><V><Q><F><V><L><R><R><T><G><P><S><L><A><G><R><P><S><S><D><S><C><P><P><P><E><R><C><L><I><R><A><S><L><P><V><K><P><R><A><A><L><G><C><E><P><R><K><T><L><T><P><E><P><A><P><S><L><S><R><P><G><P><A><A><P><V><T><P><T><P><G><C><C><T><D><L><R><G><L><E><L><R><V><Q><R><N><A><E><E><L><G><H><E><A><F><W><E><Q><E><L><R><R><E><Q><A><R><E><R><E><G><Q><A><R><L><Q><A><L><S><A><A><T><A><E><H><A><A><R><L><Q><A><L><D><A><Q><A><R><A><L><E><A><E><L><Q><L><A><A><E><A><P><G><P><P><S><P><M><A><S><A><T><E><R><L><H><Q><D><L><A><V><Q><E><R><Q><S><A><E><V><Q><G><S><L><A><L><V><S><R><A><L><E><A><A><E><R><A><L><Q><A><Q><A><Q><E><L><E><E><L><N><R><E><L><R><Q><C><N><L><Q><Q><F><I><Q><Q><T><G><A><A><L><P><P><P><P><R><P><D><R><G><P><P><G><T><Q><G><P><L><P><P><A><R><E><E><S><L><L><G><A><P><S><E><S><H><A><G><A><Q><P><R><P><R><G><G><P><H><D><A><E><L><L><E><V><A><A><A><P><A><P><E><W><C><P><L><A><A><Q><P><Q><A><L> | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.<BOP> | Q02833 |
P36508 | ZNF76_HUMAN | Zinc finger protein 523 | Homo | <M><E><S><L><G><L><H><T><V><T><L><S><D><G><T><T><A><Y><V><Q><Q><A><V><K><G><E><K><L><L><E><G><Q><V><I><Q><L><E><D><G><T><T><A><Y><I><H><Q><V><T><V><Q><K><E><A><L><S><F><E><D><G><Q><P><V><Q><L><E><D><G><S><M><A><Y><I><H><R><T><P><R><E><G><Y><D><P><S><T><L><E><A><V><Q><L><E><D><G><S><T><A><Y><I><H><H><P><V><A><V><P><S><E><S><T><I><L><A><V><Q><T><E><V><G><L><E><D><L><A><A><E><D><D><E><G><F><S><A><D><A><V><V><A><L><E><Q><Y><A><S><K><V><L><H><D><S><Q><I><P><R><N><G><K><G><Q><Q><V><G><D><R><A><F><R><C><G><Y><K><G><C><G><R><L><Y><T><T><A><H><H><L><K><V><H><E><R><A><H><T><G><D><R><P><Y><R><C><D><F><P><S><C><G><K><A><F><A><T><G><Y><G><L><K><S><H><V><R><T><H><T><G><E><K><P><Y><K><C><P><E><E><L><C><S><K><A><F><K><T><S><G><D><L><Q><K><H><V><R><T><H><T><G><E><R><P><F><Q><C><P><F><E><G><C><G><R><S><F><T><T><S><N><I><R><K><V><H><V><R><T><H><T><G><E><R><P><Y><T><C><P><E><P><H><C><G><R><G><F><T><S><A><T><N><Y><K><N><H><V><R><I><H><T><G><E><K><P><Y><V><C><T><V><P><G><C><G><K><R><F><T><E><Y><S><S><L><Y><K><H><H><V><V><H><T><H><C><K><P><Y><T><C><S><T><C><G><K><T><Y><R><Q><T><S><T><L><A><M><H><K><R><S><A><H><G><E><L><E><A><T><E><E><S><E><Q><A><L><Y><E><Q><Q><Q><L><E><A><A><S><A><A><E><E><S><P><P><P><K><R><P><R><I><A><Y><L><S><E><V><K><E><E><R><D><D><I><P><A><Q><V><A><M><V><T><E><E><D><G><A><P><Q><V><A><L><I><T><Q><D><G><A><Q><Q><V><S><L><S><P><E><D><L><Q><A><L><G><S><A><I><S><M><V><T><Q><H><G><S><T><T><L><T><I><P><S><P><D><A><D><L><A><T><S><G><T><H><T><V><T><M><V><S><A><D><G><T><Q><T><Q><P><V><T><I><I><T><S><G><A><V><V><A><E><D><S><S><V><A><S><L><R><H><Q><Q><V><A><L><L><A><T><A><N><G><T><H><I><A><V><Q><L><E><E><Q><Q><T><L><E><E><A><I><N><V><A><T><A><A><M><Q><Q><G><A><V><T><L><E><T><T><V><S><E><S><G><C> | May be involved in transcriptional regulation.<BOP> | P36508 |
Q86V81 | THOC4_HUMAN | bZIP-enhancing factor BEF | Homo | <M><A><D><K><M><D><M><S><L><D><D><I><I><K><L><N><R><S><Q><R><G><G><R><G><G><G><R><G><R><G><R><A><G><S><Q><G><G><R><G><G><G><A><Q><A><A><A><R><V><N><R><G><G><G><P><I><R><N><R><P><A><I><A><R><G><A><A><G><G><G><G><R><N><R><P><A><P><Y><S><R><P><K><Q><L><P><D><K><W><Q><H><D><L><F><D><S><G><F><G><G><G><A><G><V><E><T><G><G><K><L><L><V><S><N><L><D><F><G><V><S><D><A><D><I><Q><E><L><F><A><E><F><G><T><L><K><K><A><A><V><H><Y><D><R><S><G><R><S><L><G><T><A><D><V><H><F><E><R><K><A><D><A><L><K><A><M><K><Q><Y><N><G><V><P><L><D><G><R><P><M><N><I><Q><L><V><T><S><Q><I><D><A><Q><R><R><P><A><Q><S><V><N><R><G><G><M><T><R><N><R><G><A><G><G><F><G><G><G><G><G><T><R><R><G><T><R><G><G><A><R><G><R><G><R><G><A><G><R><N><S><K><Q><Q><L><S><A><E><E><L><D><A><Q><L><D><A><Y><N><A><R><M><D><T><S> | Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.<BOP> | Q86V81 |
O60506 | HNRPQ_HUMAN | Synaptotagmin-binding, cytoplasmic RNA-interacting protein | Homo | <M><A><T><E><H><V><N><G><N><G><T><E><E><P><M><D><T><T><S><A><V><I><H><S><E><N><F><Q><T><L><L><D><A><G><L><P><Q><K><V><A><E><K><L><D><E><I><Y><V><A><G><L><V><A><H><S><D><L><D><E><R><A><I><E><A><L><K><E><F><N><E><D><G><A><L><A><V><L><Q><Q><F><K><D><S><D><L><S><H><V><Q><N><K><S><A><F><L><C><G><V><M><K><T><Y><R><Q><R><E><K><Q><G><T><K><V><A><D><S><S><K><G><P><D><E><A><K><I><K><A><L><L><E><R><T><G><Y><T><L><D><V><T><T><G><Q><R><K><Y><G><G><P><P><P><D><S><V><Y><S><G><Q><Q><P><S><V><G><T><E><I><F><V><G><K><I><P><R><D><L><F><E><D><E><L><V><P><L><F><E><K><A><G><P><I><W><D><L><R><L><M><M><D><P><L><T><G><L><N><R><G><Y><A><F><V><T><F><C><T><K><E><A><A><Q><E><A><V><K><L><Y><N><N><H><E><I><R><S><G><K><H><I><G><V><C><I><S><V><A><N><N><R><L><F><V><G><S><I><P><K><S><K><T><K><E><Q><I><L><E><E><F><S><K><V><T><E><G><L><T><D><V><I><L><Y><H><Q><P><D><D><K><K><K><N><R><G><F><C><F><L><E><Y><E><D><H><K><T><A><A><Q><A><R><R><R><L><M><S><G><K><V><K><V><W><G><N><V><G><T><V><E><W><A><D><P><I><E><D><P><D><P><E><V><M><A><K><V><K><V><L><F><V><R><N><L><A><N><T><V><T><E><E><I><L><E><K><A><F><S><Q><F><G><K><L><E><R><V><K><K><L><K><D><Y><A><F><I><H><F><D><E><R><D><G><A><V><K><A><M><E><E><M><N><G><K><D><L><E><G><E><N><I><E><I><V><F><A><K><P><P><D><Q><K><R><K><E><R><K><A><Q><R><Q><A><A><K><N><Q><M><Y><D><D><Y><Y><Y><Y><G><P><P><H><M><P><P><P><T><R><G><R><G><R><G><G><R><G><G><Y><G><Y><P><P><D><Y><Y><G><Y><E><D><Y><Y><D><Y><Y><G><Y><D><Y><H><N><Y><R><G><G><Y><E><D><P><Y><Y><G><Y><E><D><F><Q><V><G><A><R><G><R><G><G><R><G><A><R><G><A><A><P><S><R><G><R><G><A><A><P><P><R><G><R><A><G><Y><S><Q><R><G><G><P><G><S><A><R><G><V><R><G><A><R><G><G><A><Q><Q><Q><R><G><R><G><V><R><G><A><R><G><G><R><G><G><N><V><G><G><K><R><K><A><D><G><Y><N><Q><P><D><S><K><R><R><Q><T><N><N><Q><N><W><G><S><Q><P><I><A><Q><Q><P><L><Q><G><G><D><H><S><G><N><Y><G><Y><K><S><E><N><Q><E><F><Y><Q><D><T><F><G><Q><Q><W><K> | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation | O60506 |
P00797 | RENI_HUMAN | Angiotensinogenase | Homo | <M><D><G><W><R><R><M><P><R><W><G><L><L><L><L><L><W><G><S><C><T><F><G><L><P><T><D><T><T><T><F><K><R><I><F><L><K><R><M><P><S><I><R><E><S><L><K><E><R><G><V><D><M><A><R><L><G><P><E><W><S><Q><P><M><K><R><L><T><L><G><N><T><T><S><S><V><I><L><T><N><Y><M><D><T><Q><Y><Y><G><E><I><G><I><G><T><P><P><Q><T><F><K><V><V><F><D><T><G><S><S><N><V><W><V><P><S><S><K><C><S><R><L><Y><T><A><C><V><Y><H><K><L><F><D><A><S><D><S><S><S><Y><K><H><N><G><T><E><L><T><L><R><Y><S><T><G><T><V><S><G><F><L><S><Q><D><I><I><T><V><G><G><I><T><V><T><Q><M><F><G><E><V><T><E><M><P><A><L><P><F><M><L><A><E><F><D><G><V><V><G><M><G><F><I><E><Q><A><I><G><R><V><T><P><I><F><D><N><I><I><S><Q><G><V><L><K><E><D><V><F><S><F><Y><Y><N><R><D><S><E><N><S><Q><S><L><G><G><Q><I><V><L><G><G><S><D><P><Q><H><Y><E><G><N><F><H><Y><I><N><L><I><K><T><G><V><W><Q><I><Q><M><K><G><V><S><V><G><S><S><T><L><L><C><E><D><G><C><L><A><L><V><D><T><G><A><S><Y><I><S><G><S><T><S><S><I><E><K><L><M><E><A><L><G><A><K><K><R><L><F><D><Y><V><V><K><C><N><E><G><P><T><L><P><D><I><S><F><H><L><G><G><K><E><Y><T><L><T><S><A><D><Y><V><F><Q><E><S><Y><S><S><K><K><L><C><T><L><A><I><H><A><M><D><I><P><P><P><T><G><P><T><W><A><L><G><A><T><F><I><R><K><F><Y><T><E><F><D><R><R><N><N><R><I><G><F><A><L><A><R> | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.<BOP> | P00797 |
P08034 | CXB1_HUMAN | GAP junction 28 kDa liver protein | Homo | <M><N><W><T><G><L><Y><T><L><L><S><G><V><N><R><H><S><T><A><I><G><R><V><W><L><S><V><I><F><I><F><R><I><M><V><L><V><V><A><A><E><S><V><W><G><D><E><K><S><S><F><I><C><N><T><L><Q><P><G><C><N><S><V><C><Y><D><Q><F><F><P><I><S><H><V><R><L><W><S><L><Q><L><I><L><V><S><T><P><A><L><L><V><A><M><H><V><A><H><Q><Q><H><I><E><K><K><M><L><R><L><E><G><H><G><D><P><L><H><L><E><E><V><K><R><H><K><V><H><I><S><G><T><L><W><W><T><Y><V><I><S><V><V><F><R><L><L><F><E><A><V><F><M><Y><V><F><Y><L><L><Y><P><G><Y><A><M><V><R><L><V><K><C><D><V><Y><P><C><P><N><T><V><D><C><F><V><S><R><P><T><E><K><T><V><F><T><V><F><M><L><A><A><S><G><I><C><I><I><L><N><V><A><E><V><V><Y><L><I><I><R><A><C><A><R><R><A><Q><R><R><S><N><P><P><S><R><K><G><S><G><F><G><H><R><L><S><P><E><Y><K><Q><N><E><I><N><K><L><L><S><E><Q><D><G><S><L><K><D><I><L><R><R><S><P><G><T><G><A><G><L><A><E><K><S><D><R><C><S><A><C> | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.<BOP> | P08034 |
P52895 | AK1C2_HUMAN | Type III 3-alpha-hydroxysteroid dehydrogenase | Homo | <M><D><S><K><Y><Q><C><V><K><L><N><D><G><H><F><M><P><V><L><G><F><G><T><Y><A><P><A><E><V><P><K><S><K><A><L><E><A><V><K><L><A><I><E><A><G><F><H><H><I><D><S><A><H><V><Y><N><N><E><E><Q><V><G><L><A><I><R><S><K><I><A><D><G><S><V><K><R><E><D><I><F><Y><T><S><K><L><W><S><N><S><H><R><P><E><L><V><R><P><A><L><E><R><S><L><K><N><L><Q><L><D><Y><V><D><L><Y><L><I><H><F><P><V><S><V><K><P><G><E><E><V><I><P><K><D><E><N><G><K><I><L><F><D><T><V><D><L><C><A><T><W><E><A><M><E><K><C><K><D><A><G><L><A><K><S><I><G><V><S><N><F><N><H><R><L><L><E><M><I><L><N><K><P><G><L><K><Y><K><P><V><C><N><Q><V><E><C><H><P><Y><F><N><Q><R><K><L><L><D><F><C><K><S><K><D><I><V><L><V><A><Y><S><A><L><G><S><H><R><E><E><P><W><V><D><P><N><S><P><V><L><L><E><D><P><V><L><C><A><L><A><K><K><H><K><R><T><P><A><L><I><A><L><R><Y><Q><L><Q><R><G><V><V><V><L><A><K><S><Y><N><E><Q><R><I><R><Q><N><V><Q><V><F><E><F><Q><L><T><S><E><E><M><K><A><I><D><G><L><N><R><N><V><R><Y><L><T><L><D><I><F><A><G><P><P><N><Y><P><F><S><D><E><Y> | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids . Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH . Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens . Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) . Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT . May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate . Displays affinity for bile acids .<BOP> | P52895 |
P16520 | GBB3_HUMAN | Transducin beta chain 3 | Homo | <M><G><E><M><E><Q><L><R><Q><E><A><E><Q><L><K><K><Q><I><A><D><A><R><K><A><C><A><D><V><T><L><A><E><L><V><S><G><L><E><V><V><G><R><V><Q><M><R><T><R><R><T><L><R><G><H><L><A><K><I><Y><A><M><H><W><A><T><D><S><K><L><L><V><S><A><S><Q><D><G><K><L><I><V><W><D><S><Y><T><T><N><K><V><H><A><I><P><L><R><S><S><W><V><M><T><C><A><Y><A><P><S><G><N><F><V><A><C><G><G><L><D><N><M><C><S><I><Y><N><L><K><S><R><E><G><N><V><K><V><S><R><E><L><S><A><H><T><G><Y><L><S><C><C><R><F><L><D><D><N><N><I><V><T><S><S><G><D><T><T><C><A><L><W><D><I><E><T><G><Q><Q><K><T><V><F><V><G><H><T><G><D><C><M><S><L><A><V><S><P><D><F><N><L><F><I><S><G><A><C><D><A><S><A><K><L><W><D><V><R><E><G><T><C><R><Q><T><F><T><G><H><E><S><D><I><N><A><I><C><F><F><P><N><G><E><A><I><C><T><G><S><D><D><A><S><C><R><L><F><D><L><R><A><D><Q><E><L><I><C><F><S><H><E><S><I><I><C><G><I><T><S><V><A><F><S><L><S><G><R><L><L><F><A><G><Y><D><D><F><N><C><N><V><W><D><S><M><K><S><E><R><V><G><I><L><S><G><H><D><N><R><V><S><C><L><G><V><T><A><D><G><M><A><V><A><T><G><S><W><D><S><F><L><K><I><W><N> | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<BOP> | P16520 |
P32942 | ICAM3_HUMAN | ICAM-R | Homo | <M><A><T><M><V><P><S><V><L><W><P><R><A><C><W><T><L><L><V><C><C><L><L><T><P><G><V><Q><G><Q><E><F><L><L><R><V><E><P><Q><N><P><V><L><S><A><G><G><S><L><F><V><N><C><S><T><D><C><P><S><S><E><K><I><A><L><E><T><S><L><S><K><E><L><V><A><S><G><M><G><W><A><A><F><N><L><S><N><V><T><G><N><S><R><I><L><C><S><V><Y><C><N><G><S><Q><I><T><G><S><S><N><I><T><V><Y><R><L><P><E><R><V><E><L><A><P><L><P><P><W><Q><P><V><G><Q><N><F><T><L><R><C><Q><V><E><D><G><S><P><R><T><S><L><T><V><V><L><L><R><W><E><E><E><L><S><R><Q><P><A><V><E><E><P><A><E><V><T><A><T><V><L><A><S><R><D><D><H><G><A><P><F><S><C><R><T><E><L><D><M><Q><P><Q><G><L><G><L><F><V><N><T><S><A><P><R><Q><L><R><T><F><V><L><P><V><T><P><P><R><L><V><A><P><R><F><L><E><V><E><T><S><W><P><V><D><C><T><L><D><G><L><F><P><A><S><E><A><Q><V><Y><L><A><L><G><D><Q><M><L><N><A><T><V><M><N><H><G><D><T><L><T><A><T><A><T><A><T><A><R><A><D><Q><E><G><A><R><E><I><V><C><N><V><T><L><G><G><E><R><R><E><A><R><E><N><L><T><V><F><S><F><L><G><P><I><V><N><L><S><E><P><T><A><H><E><G><S><T><V><T><V><S><C><M><A><G><A><R><V><Q><V><T><L><D><G><V><P><A><A><A><P><G><Q><P><A><Q><L><Q><L><N><A><T><E><S><D><D><G><R><S><F><F><C><S><A><T><L><E><V><D><G><E><F><L><H><R><N><S><S><V><Q><L><R><V><L><Y><G><P><K><I><D><R><A><T><C><P><Q><H><L><K><W><K><D><K><T><R><H><V><L><Q><C><Q><A><R><G><N><P><Y><P><E><L><R><C><L><K><E><G><S><S><R><E><V><P><V><G><I><P><F><F><V><N><V><T><H><N><G><T><Y><Q><C><Q><A><S><S><S><R><G><K><Y><T><L><V><V><V><M><D><I><E><A><G><S><S><H><F><V><P><V><F><V><A><V><L><L><T><L><G><V><V><T><I><V><L><A><L><M><Y><V><F><R><E><H><Q><R><S><G><S><Y><H><V><R><E><E><S><T><Y><L><P><L><T><S><M><Q><P><T><E><A><M><G><E><E><P><S><R><A><E> | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages .<BOP> | P32942 |
Q9NV88 | INT9_HUMAN | Protein related to CPSF subunits of 74 kDa | Homo | <M><K><L><Y><C><L><S><G><H><P><T><L><P><C><N><V><L><K><F><K><S><T><T><I><M><L><D><C><G><L><D><M><T><S><T><L><N><F><L><P><L><P><L><V><Q><S><P><R><L><S><N><L><P><G><W><S><L><K><D><G><N><A><F><L><D><K><E><L><K><E><C><S><G><H><V><F><V><D><S><V><P><E><F><C><L><P><E><T><E><L><I><D><L><S><T><V><D><V><I><L><I><S><N><Y><H><C><M><M><A><L><P><Y><I><T><E><H><T><G><F><T><G><T><V><Y><A><T><E><P><T><V><Q><I><G><R><L><L><M><E><E><L><V><N><F><I><E><R><V><P><K><A><Q><S><A><S><L><W><K><N><K><D><I><Q><R><L><L><P><S><P><L><K><D><A><V><E><V><S><T><W><R><R><C><Y><T><M><Q><E><V><N><S><A><L><S><K><I><Q><L><V><G><Y><S><Q><K><I><E><L><F><G><A><V><Q><V><T><P><L><S><S><G><Y><A><L><G><S><S><N><W><I><I><Q><S><H><Y><E><K><V><S><Y><V><S><G><S><S><L><L><T><T><H><P><Q><P><M><D><Q><A><S><L><K><N><S><D><V><L><V><L><T><G><L><T><Q><I><P><T><A><N><P><D><G><M><V><G><E><F><C><S><N><L><A><L><T><V><R><N><G><G><N><V><L><V><P><C><Y><P><S><G><V><I><Y><D><L><L><E><C><L><Y><Q><Y><I><D><S><A><G><L><S><S><V><P><L><Y><F><I><S><P><V><A><N><S><S><L><E><F><S><Q><I><F><A><E><W><L><C><H><N><K><Q><S><K><V><Y><L><P><E><P><P><F><P><H><A><E><L><I><Q><T><N><K><L><K><H><Y><P><S><I><H><G><D><F><S><N><D><F><R><Q><P><C><V><V><F><T><G><H><P><S><L><R><F><G><D><V><V><H><F><M><E><L><W><G><K><S><S><L><N><T><V><I><F><T><E><P><D><F><S><Y><L><E><A><L><A><P><Y><Q><P><L><A><M><K><C><I><Y><C><P><I><D><T><R><L><N><F><I><Q><V><S><K><L><L><K><E><V><Q><P><L><H><V><V><C><P><E><Q><Y><T><Q><P><P><P><A><Q><S><H><R><M><D><L><M><I><D><C><Q><P><P><A><M><S><Y><R><R><A><E><V><L><A><L><P><F><K><R><R><Y><E><K><I><E><I><M><P><E><L><A><D><S><L><V><P><M><E><I><K><P><G><I><S><L><A><T><V><S><A><V><L><H><T><K><D><N><K><H><L><L><Q><P><P><P><R><P><A><Q><P><T><S><G><K><K><R><K><R><V><S><D><D><V><P><D><C><K><V><L><K><P><L><L><S><G><S><I><P><V><E><Q><F><V><Q><T><L><E><K><H><G><F><S><D><I><K><V><E><D><T><A><K><G><H><I><V><L><L><Q><E><A><E><T><L><I><Q><I><E><E><D><S><T><H><I><I><C><D><N><D><E><M><L><R><V><R><L><R><D><L><V><L><K><F><L><Q><K><F> | Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex .<BOP> | Q9NV88 |
Q2WEN9 | CEA16_HUMAN | Carcinoembryonic antigen-like 2 | Homo | <M><A><L><T><G><Y><S><W><L><L><L><S><A><T><F><L><N><V><G><A><E><I><S><I><T><L><E><P><A><Q><P><S><E><G><D><N><V><T><L><V><V><H><G><L><S><G><E><L><L><A><Y><S><W><Y><A><G><P><T><L><S><V><S><Y><L><V><A><S><Y><I><V><S><T><G><D><E><T><P><G><P><A><H><T><G><R><E><A><V><R><P><D><G><S><L><D><I><Q><G><I><L><P><R><H><S><G><T><Y><I><L><Q><T><F><N><R><Q><L><Q><T><E><V><G><Y><G><H><V><Q><V><H><E><I><L><A><Q><P><T><V><L><A><N><S><T><A><L><V><E><R><R><D><T><L><R><L><M><C><S><S><P><S><P><T><A><E><V><R><W><F><F><N><G><G><A><L><P><V><A><L><R><L><G><L><S><P><D><G><R><V><L><A><R><H><G><I><R><R><E><E><A><G><A><Y><Q><C><E><V><W><N><P><V><S><V><S><R><S><E><P><I><N><L><T><V><Y><F><G><P><E><R><V><A><I><L><Q><D><S><T><T><R><T><G><C><T><I><K><V><D><F><N><T><S><L><T><L><W><C><V><S><R><S><C><P><E><P><E><Y><V><W><T><F><N><G><Q><A><L><K><N><G><Q><D><H><L><N><I><S><S><M><T><A><A><Q><E><G><T><Y><T><C><I><A><K><N><T><K><T><L><L><S><G><S><A><S><V><V><V><K><L><S><A><A><A><V><A><T><M><I><V><P><V><P><T><K><P><T><E><G><Q><D><V><T><L><T><V><Q><G><Y><P><K><D><L><L><V><Y><A><W><Y><R><G><P><A><S><E><P><N><R><L><L><S><Q><L><P><S><G><T><W><I><A><G><P><A><H><T><G><R><E><V><G><F><P><N><C><S><L><L><V><Q><K><L><N><L><T><D><T><G><R><Y><T><L><K><T><V><T><V><Q><G><K><T><E><T><L><E><V><E><L><Q><V><A><P><L><G> | Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.<BOP> | Q2WEN9 |
Q9HB03 | ELOV3_HUMAN | Very long chain 3-oxoacyl-CoA synthase 3 | Homo | <M><V><T><A><M><N><V><S><H><E><V><N><Q><L><F><Q><P><Y><N><F><E><L><S><K><D><M><R><P><F><F><E><E><Y><W><A><T><S><F><P><I><A><L><I><Y><L><V><L><I><A><V><G><Q><N><Y><M><K><E><R><K><G><F><N><L><Q><G><P><L><I><L><W><S><F><C><L><A><I><F><S><I><L><G><A><V><R><M><W><G><I><M><G><T><V><L><L><T><G><G><L><K><Q><T><V><C><F><I><N><F><I><D><N><S><T><V><K><F><W><S><W><V><F><L><L><S><K><V><I><E><L><G><D><T><A><F><I><I><L><R><K><R><P><L><I><F><I><H><W><Y><H><H><S><T><V><L><V><Y><T><S><F><G><Y><K><N><K><V><P><A><G><G><W><F><V><T><M><N><F><G><V><H><A><I><M><Y><T><Y><Y><T><L><K><A><A><N><V><K><P><P><K><M><L><P><M><L><I><T><S><L><Q><I><L><Q><M><F><V><G><A><I><V><S><I><L><T><Y><I><W><R><Q><D><Q><G><C><H><T><T><M><E><H><L><F><W><S><F><I><L><Y><M><T><Y><F><I><L><F><A><H><F><F><C><Q><T><Y><I><R><P><K><V><K><A><K><T><K><S><Q> | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.<BOP> | Q9HB03 |
Q8NGS4 | O13F1_HUMAN | Olfactory receptor OR9-6 | Homo | <M><F><P><A><N><W><T><S><V><K><V><F><F><F><L><G><F><F><H><Y><P><K><V><Q><V><I><I><F><A><V><C><L><L><M><Y><L><I><T><L><L><G><N><I><F><L><I><S><I><T><I><L><D><S><H><L><H><T><P><M><Y><L><F><L><S><N><L><S><F><L><D><I><W><Y><S><S><S><A><L><S><P><M><L><A><N><F><V><S><G><R><N><T><I><S><F><S><G><C><A><T><Q><M><Y><L><S><L><A><M><G><S><T><E><C><V><L><L><P><M><M><A><Y><D><R><Y><V><A><I><C><N><P><L><R><Y><P><V><I><M><N><R><R><T><C><V><Q><I><A><A><G><S><W><M><T><G><C><L><T><A><M><V><E><M><M><S><V><L><P><L><S><L><C><G><N><S><I><I><N><H><F><T><C><E><I><L><A><I><L><K><L><V><C><V><D><T><S><L><V><Q><L><I><M><L><V><I><S><V><L><L><L><P><M><P><M><L><L><I><C><I><S><Y><A><F><I><L><A><S><I><L><R><I><S><S><V><E><G><R><S><K><A><F><S><T><C><T><A><H><L><M><V><V><V><L><F><Y><G><T><A><L><S><M><H><L><K><P><S><A><V><D><S><Q><E><I><D><K><F><M><A><L><V><Y><A><G><Q><T><P><M><L><N><P><I><I><Y><S><L><R><N><K><E><V><K><V><A><L><K><K><L><L><I><R><N><H><F><N><T><A><F><I><S><I><L><K> | Odorant receptor.<BOP> | Q8NGS4 |
O43772 | MCAT_HUMAN | Solute carrier family 25 member 20 | Homo | <M><A><D><Q><P><K><P><I><S><P><L><K><N><L><L><A><G><G><F><G><G><V><C><L><V><F><V><G><H><P><L><D><T><V><K><V><R><L><Q><T><Q><P><P><S><L><P><G><Q><P><P><M><Y><S><G><T><F><D><C><F><R><K><T><L><F><R><E><G><I><T><G><L><Y><R><G><M><A><A><P><I><I><G><V><T><P><M><F><A><V><C><F><F><G><F><G><L><G><K><K><L><Q><Q><K><H><P><E><D><V><L><S><Y><P><Q><L><F><A><A><G><M><L><S><G><V><F><T><T><G><I><M><T><P><G><E><R><I><K><C><L><L><Q><I><Q><A><S><S><G><E><S><K><Y><T><G><T><L><D><C><A><K><K><L><Y><Q><E><F><G><I><R><G><I><Y><K><G><T><V><L><T><L><M><R><D><V><P><A><S><G><M><Y><F><M><T><Y><E><W><L><K><N><I><F><T><P><E><G><K><R><V><S><E><L><S><A><P><R><I><L><V><A><G><G><I><A><G><I><F><N><W><A><V><A><I><P><P><D><V><L><K><S><R><F><Q><T><A><P><P><G><K><Y><P><N><G><F><R><D><V><L><R><E><L><I><R><D><E><G><V><T><S><L><Y><K><G><F><N><A><V><M><I><R><A><F><P><A><N><A><A><C><F><L><G><F><E><V><A><M><K><F><L><N><W><A><T><P><N><L> | Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (Probable). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) .<BOP> | O43772 |
O43617 | TPPC3_HUMAN | BET3 homolog | Homo | <M><S><R><Q><A><N><R><G><T><E><S><K><K><M><S><S><E><L><F><T><L><T><Y><G><A><L><V><T><Q><L><C><K><D><Y><E><N><D><E><D><V><N><K><Q><L><D><K><M><G><F><N><I><G><V><R><L><I><E><D><F><L><A><R><S><N><V><G><R><C><H><D><F><R><E><T><A><D><V><I><A><K><V><A><F><K><M><Y><L><G><I><T><P><S><I><T><N><W><S><P><A><G><D><E><F><S><L><I><L><E><N><N><P><L><V><D><F><V><E><L><P><D><N><H><S><S><L><I><Y><S><N><L><L><C><G><V><L><R><G><A><L><E><M><V><Q><M><A><V><E><A><K><F><V><Q><D><T><L><K><G><D><G><V><T><E><I><R><M><R><F><I><R><R><I><E><D><N><L><P><A><G><E><E> | May play a role in vesicular transport from endoplasmic reticulum to Golgi.<BOP> | O43617 |
Q8WYA1 | BMAL2_HUMAN | PAS domain-containing protein 9 | Homo | <M><A><A><E><E><E><A><A><A><G><G><K><V><L><R><E><E><N><Q><C><I><A><P><V><V><S><S><R><V><S><P><G><T><R><P><T><A><M><G><S><F><S><S><H><M><T><E><F><P><R><K><R><K><G><S><D><S><D><P><S><Q><S><G><I><M><T><E><K><V><V><E><K><L><S><Q><N><P><L><T><Y><L><L><S><T><R><I><E><I><S><A><S><S><G><S><R><V><E><D><G><E><H><Q><V><K><M><K><A><F><R><E><A><H><S><Q><T><E><K><R><R><R><D><K><M><N><N><L><I><E><E><L><S><A><M><I><P><Q><C><N><P><M><A><R><K><L><D><K><L><T><V><L><R><M><A><V><Q><H><L><R><S><L><K><G><L><T><N><S><Y><V><G><S><N><Y><R><P><S><F><L><Q><D><N><E><L><R><H><L><I><L><K><T><A><E><G><F><L><F><V><V><G><C><E><R><G><K><I><L><F><V><S><K><S><V><S><K><I><L><N><Y><D><Q><A><S><L><T><G><Q><S><L><F><D><F><L><H><P><K><D><V><A><K><V><K><E><Q><L><S><S><F><D><I><S><P><R><E><K><L><I><D><A><K><T><G><L><Q><V><H><S><N><L><H><A><G><R><T><R><V><Y><S><G><S><R><R><S><F><F><C><R><I><K><S><C><K><I><S><V><K><E><E><H><G><C><L><P><N><S><K><K><K><E><H><R><K><F><Y><T><I><H><C><T><G><Y><L><R><S><W><P><P><N><I><V><G><M><E><E><E><R><N><S><K><K><D><N><S><N><F><T><C><L><V><A><I><G><R><L><Q><P><Y><I><V><P><Q><N><S><G><E><I><N><V><K><P><T><E><F><I><T><R><F><A><V><N><G><K><F><V><Y><V><D><Q><R><A><T><A><I><L><G><Y><L><P><Q><E><L><L><G><T><S><C><Y><E><Y><F><H><Q><D><D><H><N><N><L><T><D><K><H><K><A><V><L><Q><S><K><E><K><I><L><T><D><S><Y><K><F><R><A><K><D><G><S><F><V><T><L><K><S><Q><W><F><S><F><T><N><P><W><T><K><E><L><E><Y><I><V><S><V><N><T><L><V><L><G><H><S><E><P><G><E><A><S><F><L><P><C><S><S><Q><S><S><E><E><S><S><R><Q><S><C><M><S><V><P><G><M><S><T><G><T><V><L><G><A><G><S><I><G><T><D><I><A><N><E><I><L><D><L><Q><R><L><Q><S><S><S><Y><L><D><D><S><S><P><T><G><L><M><K><D><T><H><T><V><N><C><R><S><M><S><N><K><E><L><F><P><P><S><P><S><E><M><G><E><L><E><A><T><R><Q><N><Q><S><T><V><A><V><H><S><H><E><P><L><L><S><D><G><A><Q><L><D><F><D><A><L><C><D><N><D><D><T><A><M><A><A><F><M><N><Y><L><E><A><E><G><G><L><G><D><P><G><D><F><S><D><I><Q><W><T><L> | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment | Q8WYA1 |
Q7L513 | FCRLA_HUMAN | Fc receptor-related protein X | Homo | <M><K><L><G><C><V><L><M><A><W><A><L><Y><L><S><L><G><V><L><W><V><A><Q><M><L><L><A><A><S><F><E><T><L><Q><C><E><G><P><V><C><T><E><E><S><S><C><H><T><E><D><D><L><T><D><A><R><E><A><G><F><Q><V><K><A><Y><T><F><S><E><P><F><H><L><I><V><S><Y><D><W><L><I><L><Q><G><P><A><K><P><V><F><E><G><D><L><L><V><L><R><C><Q><A><W><Q><D><W><P><L><T><Q><V><T><F><Y><R><D><G><S><A><L><G><P><P><G><P><N><R><E><F><S><I><T><V><V><Q><K><A><D><S><G><H><Y><H><C><S><G><I><F><Q><S><P><G><P><G><I><P><E><T><A><S><V><V><A><I><T><V><Q><E><L><F><P><A><P><I><L><R><A><V><P><S><A><E><P><Q><A><G><S><P><M><T><L><S><C><Q><T><K><L><P><L><Q><R><S><A><A><R><L><L><F><S><F><Y><K><D><G><R><I><V><Q><S><R><G><L><S><S><E><F><Q><I><P><T><A><S><E><D><H><S><G><S><Y><W><C><E><A><A><T><E><D><N><Q><V><W><K><Q><S><P><Q><L><E><I><R><V><Q><G><A><S><S><S><A><A><P><P><T><L><N><P><A><P><Q><K><S><A><A><P><G><T><A><P><E><E><A><P><G><P><L><P><P><P><P><T><P><S><S><E><D><P><G><F><S><S><P><L><G><M><P><D><P><H><L><Y><H><Q><M><G><L><L><L><K><H><M><Q><D><V><R><V><L><L><G><H><L><L><M><E><L><R><E><L><S><G><H><R><K><P><G><T><T><K><A><T><A><E> | May be implicated in B-cell differentiation and lymphomagenesis.<BOP> | Q7L513 |
Q96B96 | LDAF1_HUMAN | Transmembrane protein 159 | Homo | <M><A><K><E><E><P><Q><S><I><S><R><D><L><Q><E><L><Q><K><K><L><S><L><L><I><D><S><F><Q><N><N><S><K><V><V><A><F><M><K><S><P><V><G><Q><Y><L><D><S><H><P><F><L><A><F><T><L><L><V><F><I><V><M><S><A><V><P><V><G><F><F><L><L><I><V><V><L><T><T><L><A><A><L><L><G><V><I><I><L><E><G><L><V><I><S><V><G><G><F><S><L><L><C><I><L><C><G><L><G><F><V><S><L><A><M><S><G><M><M><I><A><S><Y><V><V><V><S><S><L><I><S><C><W><F><S><P><R><P><L><T><Q><Q><N><T><S><C><D><F><L><P><A><M><K><S><A><E><F><E><G><L><Y><Q><E> | Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis . In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum .<BOP> | Q96B96 |
Q04917 | 1433F_HUMAN | Protein AS1 | Homo | <M><G><D><R><E><Q><L><L><Q><R><A><R><L><A><E><Q><A><E><R><Y><D><D><M><A><S><A><M><K><A><V><T><E><L><N><E><P><L><S><N><E><D><R><N><L><L><S><V><A><Y><K><N><V><V><G><A><R><R><S><S><W><R><V><I><S><S><I><E><Q><K><T><M><A><D><G><N><E><K><K><L><E><K><V><K><A><Y><R><E><K><I><E><K><E><L><E><T><V><C><N><D><V><L><S><L><L><D><K><F><L><I><K><N><C><N><D><F><Q><Y><E><S><K><V><F><Y><L><K><M><K><G><D><Y><Y><R><Y><L><A><E><V><A><S><G><E><K><K><N><S><V><V><E><A><S><E><A><A><Y><K><E><A><F><E><I><S><K><E><Q><M><Q><P><T><H><P><I><R><L><G><L><A><L><N><F><S><V><F><Y><Y><E><I><Q><N><A><P><E><Q><A><C><L><L><A><K><Q><A><F><D><D><A><I><A><E><L><D><T><L><N><E><D><S><Y><K><D><S><T><L><I><M><Q><L><L><R><D><N><L><T><L><W><T><S><D><Q><Q><D><E><E><A><G><E><G><N> | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.<BOP> | Q04917 |
Q8NH64 | O51A7_HUMAN | Olfactory receptor OR11-27 | Homo | <M><S><V><L><N><N><S><E><V><K><L><F><L><L><I><G><I><P><G><L><E><H><A><H><I><W><F><S><I><P><I><C><L><M><Y><L><L><A><I><M><G><N><C><T><I><L><F><I><I><K><T><E><P><S><L><H><E><P><M><Y><Y><F><L><A><M><L><A><V><S><D><M><G><L><S><L><S><S><L><P><T><M><L><R><V><F><L><F><N><A><M><G><I><S><P><N><A><C><F><A><Q><E><F><F><I><H><G><F><T><V><M><E><S><S><V><L><L><I><M><S><L><D><R><F><L><A><I><H><N><P><L><R><Y><S><S><I><L><T><S><N><R><V><A><K><M><G><L><I><L><A><I><R><S><I><L><L><V><I><P><F><P><F><T><L><R><R><L><K><Y><C><Q><K><N><L><L><S><H><S><Y><C><L><H><Q><D><T><M><K><L><A><C><S><D><N><K><T><N><V><I><Y><G><F><F><I><A><L><C><T><M><L><D><L><A><L><I><V><L><S><Y><V><L><I><L><K><T><I><L><S><I><A><S><L><A><E><R><L><K><A><L><N><T><C><V><S><H><I><C><A><V><L><T><F><Y><V><P><I><I><T><L><A><A><M><H><H><F><A><K><H><K><S><P><L><V><V><I><L><I><A><D><M><F><L><L><V><P><P><L><M><N><P><I><V><Y><C><V><K><T><R><Q><I><W><E><K><I><L><G><K><L><L><N><V><C><G><R> | Odorant receptor.<BOP> | Q8NH64 |
Q16654 | PDK4_HUMAN | Pyruvate dehydrogenase kinase isoform 4 | Homo | <M><K><A><A><R><F><V><L><R><S><A><G><S><L><N><G><A><G><L><V><P><R><E><V><E><H><F><S><R><Y><S><P><S><P><L><S><M><K><Q><L><L><D><F><G><S><E><N><A><C><E><R><T><S><F><A><F><L><R><Q><E><L><P><V><R><L><A><N><I><L><K><E><I><D><I><L><P><T><Q><L><V><N><T><S><S><V><Q><L><V><K><S><W><Y><I><Q><S><L><M><D><L><V><E><F><H><E><K><S><P><D><D><Q><K><A><L><S><D><F><V><D><T><L><I><K><V><R><N><R><H><H><N><V><V><P><T><M><A><Q><G><I><I><E><Y><K><D><A><C><T><V><D><P><V><T><N><Q><N><L><Q><Y><F><L><D><R><F><Y><M><N><R><I><S><T><R><M><L><M><N><Q><H><I><L><I><F><S><D><S><Q><T><G><N><P><S><H><I><G><S><I><D><P><N><C><D><V><V><A><V><V><Q><D><A><F><E><C><S><R><M><L><C><D><Q><Y><Y><L><S><S><P><E><L><K><L><T><Q><V><N><G><K><F><P><D><Q><P><I><H><I><V><Y><V><P><S><H><L><H><H><M><L><F><E><L><F><K><N><A><M><R><A><T><V><E><H><Q><E><N><Q><P><S><L><T><P><I><E><V><I><V><V><L><G><K><E><D><L><T><I><K><I><S><D><R><G><G><G><V><P><L><R><I><I><D><R><L><F><S><Y><T><Y><S><T><A><P><T><P><V><M><D><N><S><R><N><A><P><L><A><G><F><G><Y><G><L><P><I><S><R><L><Y><A><K><Y><F><Q><G><D><L><N><L><Y><S><L><S><G><Y><G><T><D><A><I><I><Y><L><K><A><L><S><S><E><S><I><E><K><L><P><V><F><N><K><S><A><F><K><H><Y><Q><M><S><S><E><A><D><D><W><C><I><P><S><R><E><P><K><N><L><A><K><E><V><A><M> | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.<BOP> | Q16654 |
P52798 | EFNA4_HUMAN | EPH-related receptor tyrosine kinase ligand 4 | Homo | <M><R><L><L><P><L><L><R><T><V><L><W><A><A><F><L><G><S><P><L><R><G><G><S><S><L><R><H><V><V><Y><W><N><S><S><N><P><R><L><L><R><G><D><A><V><V><E><L><G><L><N><D><Y><L><D><I><V><C><P><H><Y><E><G><P><G><P><P><E><G><P><E><T><F><A><L><Y><M><V><D><W><P><G><Y><E><S><C><Q><A><E><G><P><R><A><Y><K><R><W><V><C><S><L><P><F><G><H><V><Q><F><S><E><K><I><Q><R><F><T><P><F><S><L><G><F><E><F><L><P><G><E><T><Y><Y><Y><I><S><V><P><T><P><E><S><S><G><Q><C><L><R><L><Q><V><S><V><C><C><K><E><R><K><S><E><S><A><H><P><V><G><S><P><G><E><S><G><T><S><G><W><R><G><G><D><T><P><S><P><L><C><L><L><L><L><L><L><L><L><I><L><R><L><L><R><I><L> | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.<BOP> | P52798 |
P49720 | PSB3_HUMAN | Proteasome theta chain | Homo | <M><S><I><M><S><Y><N><G><G><A><V><M><A><M><K><G><K><N><C><V><A><I><A><A><D><R><R><F><G><I><Q><A><Q><M><V><T><T><D><F><Q><K><I><F><P><M><G><D><R><L><Y><I><G><L><A><G><L><A><T><D><V><Q><T><V><A><Q><R><L><K><F><R><L><N><L><Y><E><L><K><E><G><R><Q><I><K><P><Y><T><L><M><S><M><V><A><N><L><L><Y><E><K><R><F><G><P><Y><Y><T><E><P><V><I><A><G><L><D><P><K><T><F><K><P><F><I><C><S><L><D><L><I><G><C><P><M><V><T><D><D><F><V><V><S><G><T><C><A><E><Q><M><Y><G><M><C><E><S><L><W><E><P><N><M><D><P><D><H><L><F><E><T><I><S><Q><A><M><L><N><A><V><D><R><D><A><V><S><G><M><G><V><I><V><H><I><I><E><K><D><K><I><T><T><R><T><L><K><A><R><M><D> | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).<BOP> | P49720 |
Q6ZT62 | BGIN_HUMAN | Chimeric SH3BP1-PDXP protein | Homo | <M><D><R><G><L><P><G><P><A><T><P><A><V><T><P><Q><P><P><A><R><P><Q><D><D><E><E><A><A><A><P><H><A><A><A><G><P><D><G><Q><L><G><T><V><E><Q><R><L><E><P><A><K><R><A><A><H><N><I><H><K><R><L><Q><A><C><L><Q><G><Q><S><G><A><D><M><D><K><R><V><K><K><L><P><L><M><A><L><S><T><T><M><A><E><S><F><K><E><L><D><P><D><S><S><M><G><K><A><L><E><M><S><C><A><I><Q><N><Q><L><A><R><I><L><A><E><F><E><M><T><L><E><R><D><V><L><Q><P><L><S><R><L><S><E><E><E><L><P><A><I><L><K><H><K><K><S><L><Q><K><L><V><S><D><W><N><T><L><K><S><R><L><S><Q><A><T><K><N><S><G><S><S><Q><G><L><G><G><S><P><G><S><H><S><H><T><T><M><A><N><K><V><E><T><L><K><E><E><E><E><E><L><K><R><K><V><E><Q><C><R><D><E><Y><L><A><D><L><Y><H><F><V><T><K><E><D><S><Y><A><N><Y><F><I><R><L><L><E><I><Q><A><D><Y><H><R><R><S><L><S><S><L><D><T><A><L><A><E><L><R><E><N><H><G><Q><A><D><H><S><P><S><M><T><A><T><H><F><P><R><V><Y><G><V><S><L><A><T><H><L><Q><E><L><G><R><E><I><A><L><P><I><E><A><C><V><M><M><L><L><S><E><G><M><K><E><E><G><L><F><R><L><A><A><G><A><S><V><L><K><R><L><K><Q><T><M><A><S><D><P><H><S><L><E><E><F><C><S><D><P><H><A><V><A><G><A><L><K><S><Y><L><R><E><L><P><E><P><L><M><T><F><D><L><Y><D><D><W><M><R><A><A><S><L><K><E><P><G><A><R><L><Q><A><L><Q><E><V><C><S><R><L><P><P><E><N><L><S><N><L><R><Y><L><M><K><F><L><A><R><L><A><E><E><Q><E><V><N><K><M><T><P><S><N><I><A><I><V><L><G><P><N><L><L><W><P><P><E><K><E><G><D><Q><A><Q><L><D><A><A><S><V><S><S><I><Q><V><V><G><V><V><E><A><L><I><Q><S><A><D><T><L><F><P><G><D><I><N><F><N><V><S><G><L><F><S><A><V><T><L><Q><D><T><V><S><D><R><L><A><S><E><E><L><P><S><T><A><V><P><T><P><A><T><T><P><A><P><A><P><A><P><A><P><A><P><A><P><A><L><A><S><A><A><T><K><E><R><T><E><S><E><V><P><P><R><P><A><S><P><K><V><T><R><S><P><P><E><T><A><A><P><V><E><D><M><A><R><R><S><T><G><S><L><A><A><A><V><E><T><A><S><G><R><Q><A><L><V><V><G><K><P><S><P><Y><M><F><E><C><I><T><E><N><F><S><I><D><P><A><R><T><L><M><V><G><D><R><L><E><T><D><I><L><F><G><H><R><C><G><M><T><T><V><L><T><L><T><G><V><S><R><L><E><E><A><Q><A><Y><L><A><A><G><Q><H><D><L><V><P><H><Y><Y><V><E><S><I><A><D><L><T><E><G><L><E><D> | GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains.<BOP> | Q6ZT62 |
P29972 | AQP1_HUMAN | Water channel protein for red blood cells and kidney proximal tubule | Homo | <M><A><S><E><F><K><K><K><L><F><W><R><A><V><V><A><E><F><L><A><T><T><L><F><V><F><I><S><I><G><S><A><L><G><F><K><Y><P><V><G><N><N><Q><T><A><V><Q><D><N><V><K><V><S><L><A><F><G><L><S><I><A><T><L><A><Q><S><V><G><H><I><S><G><A><H><L><N><P><A><V><T><L><G><L><L><L><S><C><Q><I><S><I><F><R><A><L><M><Y><I><I><A><Q><C><V><G><A><I><V><A><T><A><I><L><S><G><I><T><S><S><L><T><G><N><S><L><G><R><N><D><L><A><D><G><V><N><S><G><Q><G><L><G><I><E><I><I><G><T><L><Q><L><V><L><C><V><L><A><T><T><D><R><R><R><R><D><L><G><G><S><A><P><L><A><I><G><L><S><V><A><L><G><H><L><L><A><I><D><Y><T><G><C><G><I><N><P><A><R><S><F><G><S><A><V><I><T><H><N><F><S><N><H><W><I><F><W><V><G><P><F><I><G><G><A><L><A><V><L><I><Y><D><F><I><L><A><P><R><S><S><D><L><T><D><R><V><K><V><W><T><S><G><Q><V><E><E><Y><D><L><D><A><D><D><I><N><S><R><V><E><M><K><P><K> | Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.<BOP> | P29972 |
P10767 | FGF6_HUMAN | Heparin-binding growth factor 6 | Homo | <M><A><L><G><Q><K><L><F><I><T><M><S><R><G><A><G><R><L><Q><G><T><L><W><A><L><V><F><L><G><I><L><V><G><M><V><V><P><S><P><A><G><T><R><A><N><N><T><L><L><D><S><R><G><W><G><T><L><L><S><R><S><R><A><G><L><A><G><E><I><A><G><V><N><W><E><S><G><Y><L><V><G><I><K><R><Q><R><R><L><Y><C><N><V><G><I><G><F><H><L><Q><V><L><P><D><G><R><I><S><G><T><H><E><E><N><P><Y><S><L><L><E><I><S><T><V><E><R><G><V><V><S><L><F><G><V><R><S><A><L><F><V><A><M><N><S><K><G><R><L><Y><A><T><P><S><F><Q><E><E><C><K><F><R><E><T><L><L><P><N><N><Y><N><A><Y><E><S><D><L><Y><Q><G><T><Y><I><A><L><S><K><Y><G><R><V><K><R><G><S><K><V><S><P><I><M><T><V><T><H><F><L><P><R><I> | Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.<BOP> | P10767 |
Q5RIA9 | ZNG1E_HUMAN | Cobalamin synthase W domain-containing protein 5 | Homo | <M><L><P><A><V><G><S><V><D><E><E><E><D><P><A><E><E><D><C><P><E><L><V><P><I><E><T><T><Q><S><E><E><E><E><K><S><G><L><G><A><K><I><P><V><T><I><I><T><G><Y><L><G><A><G><K><T><T><L><L><N><Y><I><L><T><E><Q><H><S><K><R><V><A><V><I><L><N><E><S><G><E><G><S><A><L><E><K><S><L><A><V><S><Q><G><G><E><L><Y><E><E><W><L><E><L><R><N><G><C><L><C><C><S><V><K><D><N><G><L><R><A><I><E><N><L><M><Q><K><K><G><K><F><D><D><I><L><L><E><T><T><G><L><A><D><P><G><A><V><T><S><M><F><W><V><D><A><E><L><G><S><D><I><Y><L><D><G><I><I><T><I><V><D><S><K><Y><G><L><K><H><L><T><E><E><K><P><D><G><L><I><N><E><A><T><R><Q><V><A><L><A><D><I><I><L><I><N><K><T><D><L><V><P><E><E><D><V><K><K><L><R><T><T><I><R><S><I><N><G><L><G><Q><I><L><E><T><Q><R><S><R><V><D><L><S><N><V><L><D><L><H><A><F><D><S><L><S><G><I><S><L><Q><K><K><L><Q><H><V><P><G><T><Q><P><H><L><D><Q><S><I><V><T><I><T><F><E><V><P><G><N><A><K><E><E><H><L><N><M><F><I><Q><N><L><L><W><E><K><N><V><R><N><K><D><N><H><C><M><E><V><I><R><L><K><G><L><V><S><I><K><D><K><S><Q><Q><V><I><V><Q><G><V><H><E><L><Y><D><L><E><E><T><P><V><S><W><K><D><D><T><E><R><T><N><R><L><V><L><I><G><R><N><L><D><K><D><I><L><K><Q><L><F><I><A><T><V><T><E><T><E><K><Q><W><T><T><H><F><K><E><D><Q><V><C><T> | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1.<BOP> | Q5RIA9 |
Q9UH73 | COE1_HUMAN | Early B-cell factor | Homo | <M><F><G><I><Q><E><S><I><Q><R><S><G><S><S><M><K><E><E><P><L><G><S><G><M><N><A><V><R><T><W><M><Q><G><A><G><V><L><D><A><N><T><A><A><Q><S><G><V><G><L><A><R><A><H><F><E><K><Q><P><P><S><N><L><R><K><S><N><F><F><H><F><V><L><A><L><Y><D><R><Q><G><Q><P><V><E><I><E><R><T><A><F><V><G><F><V><E><K><E><K><E><A><N><S><E><K><T><N><N><G><I><H><Y><R><L><Q><L><L><Y><S><N><G><I><R><T><E><Q><D><F><Y><V><R><L><I><D><S><M><T><K><Q><A><I><V><Y><E><G><Q><D><K><N><P><E><M><C><R><V><L><L><T><H><E><I><M><C><S><R><C><C><D><K><K><S><C><G><N><R><N><E><T><P><S><D><P><V><I><I><D><R><F><F><L><K><F><F><L><K><C><N><Q><N><C><L><K><N><A><G><N><P><R><D><M><R><R><F><Q><V><V><V><S><T><T><V><N><V><D><G><H><V><L><A><V><S><D><N><M><F><V><H><N><N><S><K><H><G><R><R><A><R><R><L><D><P><S><E><G><T><P><S><Y><L><E><H><A><T><P><C><I><K><A><I><S><P><S><E><G><W><T><T><G><G><A><T><V><I><I><I><G><D><N><F><F><D><G><L><Q><V><I><F><G><T><M><L><V><W><S><E><L><I><T><P><H><A><I><R><V><Q><T><P><P><R><H><I><P><G><V><V><E><V><T><L><S><Y><K><S><K><Q><F><C><K><G><T><P><G><R><F><I><Y><T><A><L><N><E><P><T><I><D><Y><G><F><Q><R><L><Q><K><V><I><P><R><H><P><G><D><P><E><R><L><P><K><E><V><I><L><K><R><A><A><D><L><V><E><A><L><Y><G><M><P><H><N><N><Q><E><I><I><L><K><R><A><A><D><I><A><E><A><L><Y><S><V><P><R><N><H><N><Q><L><P><A><L><A><N><T><S><V><H><A><G><M><M><G><V><N><S><F><S><G><Q><L><A><V><N><V><S><E><A><S><Q><A><T><N><Q><G><F><T><R><N><S><S><S><V><S><P><H><G><Y><V><P><S><T><T><P><Q><Q><T><N><Y><N><S><V><T><T><S><M><N><G><Y><G><S><A><A><M><S><N><L><G><G><S><P><T><F><L><N><G><S><A><A><N><S><P><Y><A><I><V><P><S><S><P><T><M><A><S><S><T><S><L><P><S><N><C><S><S><S><S><G><I><F><S><F><S><P><A><N><M><V><S><A><V><K><Q><K><S><A><F><A><P><V><V><R><P><Q><T><S><P><P><P><T><C><T><S><T><N><G><N><S><L><Q><A><I><S><G><M><I><V><P><P><M> | (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells . In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency .<BOP> | Q9UH73 |
Q9NSI2 | SLX9_HUMAN | Ribosome biogenesis protein SLX9 homolog | Homo | <M><G><K><V><R><G><L><R><A><R><V><H><Q><A><A><V><R><P><K><G><E><A><A><P><G><P><A><P><P><A><P><E><A><T><P><P><P><A><S><A><A><G><K><D><W><A><F><I><N><T><N><I><F><A><R><T><K><I><D><P><S><A><L><V><Q><K><L><E><L><D><V><R><S><V><T><S><V><R><R><G><E><A><G><S><S><A><R><S><V><P><S><I><R><R><G><A><E><A><K><T><V><L><P><K><K><E><K><M><K><L><R><R><E><Q><W><L><Q><K><I><E><A><I><K><L><A><E><Q><K><H><R><E><E><R><R><R><R><A><T><V><V><V><G><D><L><H><P><L><R><D><A><L><P><E><L><L><G><L><E><A><G><S><R><R><Q><A><R><S><R><E><S><N><K><P><R><P><S><E><L><S><R><M><S><A><A><Q><R><Q><Q><L><L><E><E><E><R><T><R><F><Q><E><L><L><A><S><P><A><Y><R><A><S><P><L><V><A><I><G><Q><T><L><A><R><Q><M><Q><L><E><D><G><G><Q><L> | May be involved in ribosome biogenesis.<BOP> | Q9NSI2 |
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