accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q12934 | BFSP1_HUMAN | Filensin N-terminal fragment | Homo | <M><Y><R><R><S><Y><V><F><Q><T><R><K><E><Q><Y><E><H><A><D><E><A><S><R><A><A><E><P><E><R><P><A><D><E><G><W><A><G><A><T><S><L><A><A><L><Q><G><L><G><E><R><V><A><A><H><V><Q><R><A><R><A><L><E><Q><R><H><A><G><L><R><R><Q><L><D><A><F><Q><R><L><G><E><L><A><G><P><E><D><A><L><A><R><Q><V><E><S><N><R><Q><R><V><R><D><L><E><A><E><R><A><R><L><E><R><Q><G><T><E><A><Q><R><A><L><D><E><F><R><S><K><Y><E><N><E><C><E><C><Q><L><L><L><K><E><M><L><E><R><L><N><K><E><A><D><E><A><L><L><H><N><L><R><L><Q><L><E><A><Q><F><L><Q><D><D><I><S><A><A><K><D><R><H><K><K><N><L><L><E><V><Q><T><Y><I><S><I><L><Q><Q><I><I><H><T><T><P><P><A><S><I><V><T><S><G><M><R><E><E><K><L><L><T><E><R><E><V><A><A><L><R><S><Q><L><E><E><G><R><E><V><L><S><H><L><Q><A><Q><R><V><E><L><Q><A><Q><T><T><T><L><E><Q><A><I><K><S><A><H><E><C><Y><D><D><E><I><Q><L><Y><N><E><Q><I><E><T><L><R><K><E><I><E><E><T><E><R><V><L><E><K><S><S><Y><D><C><R><Q><L><A><V><A><Q><Q><T><L><K><N><E><L><D><R><Y><H><R><I><I><E><I><E><G><N><R><L><T><S><A><F><I><E><T><P><I><P><L><F><T><Q><S><H><G><V><S><L><S><T><G><S><G><G><K><D><L><T><R><A><L><Q><D><I><T><A><A><K><P><R><Q><K><A><L><P><K><N><V><P><R><R><K><E><I><I><T><K><D><K><T><N><G><A><L><E><D><A><P><L><K><G><L><E><D><T><K><L><V><Q><V><V><L><K><E><E><S><E><S><K><F><E><S><E><S><K><E><V><S><P><L><T><Q><E><G><A><P><E><D><V><P><D><G><G><Q><I><S><K><G><F><G><K><L><Y><R><K><V><K><E><K><V><R><S><P><K><E><P><E><T><P><T><E><L><Y><T><K><E><R><H><V><L><V><T><G><D><A><N><Y><V><D><P><R><F><Y><V><S><S><I><T><A><K><G><G><V><A><V><S><V><A><E><D><S><V><L><Y><D><G><Q><V><E><P><S><P><E><S><P><K><P><P><L><E><N><G><Q><V><G><L><Q><E><K><E><D><G><Q><P><I><D><Q><Q><P><I><D><K><E><I><E><P><D><G><A><E><L><E><G><P><E><E><K><R><E><G><E><E><R><D><E><E><S><R><R><P><C><A><M><V><T><P><G><A><E><E><P><S><I><P><E><P><P><K><P><A><A><D><Q><D><G><A><E><V><L><G><T><R><S><R><S><L><P><E><K><G><P><P><K><A><L><A><Y><K><T><V><E><V><V><E><S><I><E><K><I><S><T><E><S><I><Q><T><Y><E><E><T><A><V><I><V><E><T><M><I><G><K><T><K><S><D><K><K><K><S><G><E><K><S><S> | Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA . Involved in altering the calcium regulation of MIP water permeability .<BOP> | Q12934 |
Q8WUX2 | CHAC2_HUMAN | Cation transport regulator-like protein 2 | Homo | <M><W><V><F><G><Y><G><S><L><I><W><K><V><D><F><P><Y><Q><D><K><L><V><G><Y><I><T><N><Y><S><R><R><F><W><Q><G><S><T><D><H><R><G><V><P><G><K><P><G><R><V><V><T><L><V><E><D><P><A><G><C><V><W><G><V><A><Y><R><L><P><V><G><K><E><E><E><V><K><A><Y><L><D><F><R><E><K><G><G><Y><R><T><T><T><V><I><F><Y><P><K><D><P><T><T><K><P><F><S><V><L><L><Y><I><G><T><C><D><N><P><D><Y><L><G><P><A><P><L><E><D><I><A><E><Q><I><F><N><A><A><G><P><S><G><R><N><T><E><Y><L><F><E><L><A><N><S><I><R><N><L><V><P><E><E><A><D><E><H><L><F><A><L><E><K><L><V><K><E><R><L><E><G><K><Q><N><L><N><C><I> | Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.<BOP> | Q8WUX2 |
Q6UWM7 | LCTL_HUMAN | Klotho/lactase-phlorizin hydrolase-related protein | Homo | <M><K><P><V><W><V><A><T><L><L><W><M><L><L><L><V><P><R><L><G><A><A><R><K><G><S><P><E><E><A><S><F><Y><Y><G><T><F><P><L><G><F><S><W><G><V><G><S><S><A><Y><Q><T><E><G><A><W><D><Q><D><G><K><G><P><S><I><W><D><V><F><T><H><S><G><K><G><K><V><L><G><N><E><T><A><D><V><A><C><D><G><Y><Y><K><V><Q><E><D><I><I><L><L><R><E><L><H><V><N><H><Y><R><F><S><L><S><W><P><R><L><L><P><T><G><I><R><A><E><Q><V><N><K><K><G><I><E><F><Y><S><D><L><I><D><A><L><L><S><S><N><I><T><P><I><V><T><L><H><H><W><D><L><P><Q><L><L><Q><V><K><Y><G><G><W><Q><N><V><S><M><A><N><Y><F><R><D><Y><A><N><L><C><F><E><A><F><G><D><R><V><K><H><W><I><T><F><S><D><P><R><A><M><A><E><K><G><Y><E><T><G><H><H><A><P><G><L><K><L><R><G><T><G><L><Y><K><A><A><H><H><I><I><K><A><H><A><K><A><W><H><S><Y><N><T><T><W><R><S><K><Q><Q><G><L><V><G><I><S><L><N><C><D><W><G><E><P><V><D><I><S><N><P><K><D><L><E><A><A><E><R><Y><L><Q><F><C><L><G><W><F><A><N><P><I><Y><A><G><D><Y><P><Q><V><M><K><D><Y><I><G><R><K><S><A><E><Q><G><L><E><M><S><R><L><P><V><F><S><L><Q><E><K><S><Y><I><K><G><T><S><D><F><L><G><L><G><H><F><T><T><R><Y><I><T><E><R><N><Y><P><S><R><Q><G><P><S><Y><Q><N><D><R><D><L><I><E><L><V><D><P><N><W><P><D><L><G><S><K><W><L><Y><S><V><P><W><G><F><R><R><L><L><N><F><A><Q><T><Q><Y><G><D><P><P><I><Y><V><M><E><N><G><A><S><Q><K><F><H><C><T><Q><L><C><D><E><W><R><I><Q><Y><L><K><G><Y><I><N><E><M><L><K><A><I><K><D><G><A><N><I><K><G><Y><T><S><W><S><L><L><D><K><F><E><W><E><K><G><Y><S><D><R><Y><G><F><Y><Y><V><E><F><N><D><R><N><K><P><R><Y><P><K><A><S><V><Q><Y><Y><K><K><I><I><I><A><N><G><F><P><N><P><R><E><V><E><S><W><Y><L><K><A><L><E><T><C><S><I><N><N><Q><M><L><A><A><E><P><L><L><S><H><M><Q><M><V><T><E><I><V><V><P><T><V><C><S><L><C><V><L><I><T><A><V><L><L><M><L><L><L><R><R><Q><S> | Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens.<BOP> | Q6UWM7 |
Q96J87 | CELF6_HUMAN | RNA-binding protein BRUNOL-6 | Homo | <M><A><A><A><P><G><G><S><A><Q><P><A><G><P><G><P><R><L><G><F><S><T><A><D><S><G><V><G><M><S><G><L><N><P><G><P><A><V><P><M><K><D><H><D><A><I><K><L><F><V><G><Q><I><P><R><G><L><D><E><Q><D><L><K><P><L><F><E><E><F><G><R><I><Y><E><L><T><V><L><K><D><R><L><T><G><L><H><K><G><C><A><F><L><T><Y><C><A><R><D><S><A><L><K><A><Q><S><A><L><H><E><Q><K><T><L><P><G><M><N><R><P><I><Q><V><K><P><A><A><S><E><G><R><G><E><D><R><K><L><F><V><G><M><L><G><K><Q><Q><G><E><E><D><V><R><R><L><F><Q><P><F><G><H><I><E><E><C><T><V><L><R><S><P><D><G><T><S><K><G><C><A><F><V><K><F><G><S><Q><G><E><A><Q><A><A><I><R><G><L><H><G><S><R><T><M><A><G><A><S><S><S><L><V><V><K><L><A><D><T><D><R><E><R><A><L><R><R><M><Q><Q><M><A><G><H><L><G><A><F><H><P><A><P><L><P><L><G><A><C><G><A><Y><T><T><A><I><L><Q><H><Q><A><A><L><L><A><A><A><Q><G><P><G><L><G><P><V><A><A><V><A><A><Q><M><Q><H><V><A><A><F><S><L><V><A><A><P><L><L><P><A><A><A><A><N><S><P><P><G><S><G><P><G><T><L><P><G><L><P><A><P><I><G><V><N><G><F><G><P><L><T><P><Q><T><N><G><Q><P><G><S><D><T><L><Y><N><N><G><L><S><P><Y><P><A><Q><S><P><G><V><A><D><P><L><Q><Q><A><Y><A><G><M><H><H><Y><A><A><A><Y><P><S><A><Y><A><P><V><S><T><A><F><P><Q><Q><P><S><A><L><P><Q><Q><Q><R><E><G><P><E><G><C><N><L><F><I><Y><H><L><P><Q><E><F><G><D><A><E><L><I><Q><T><F><L><P><F><G><A><V><V><S><A><K><V><F><V><D><R><A><T><N><Q><S><K><C><F><G><F><V><S><F><D><N><P><T><S><A><Q><T><A><I><Q><A><M><N><G><F><Q><I><G><M><K><R><L><K><V><Q><L><K><R><P><K><D><A><N><R><P><Y> | RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.<BOP> | Q96J87 |
Q15056 | IF4H_HUMAN | Williams-Beuren syndrome chromosomal region 1 protein | Homo | <M><A><D><F><D><T><Y><D><D><R><A><Y><S><S><F><G><G><G><R><G><S><R><G><S><A><G><G><H><G><S><R><S><Q><K><E><L><P><T><E><P><P><Y><T><A><Y><V><G><N><L><P><F><N><T><V><Q><G><D><I><D><A><I><F><K><D><L><S><I><R><S><V><R><L><V><R><D><K><D><T><D><K><F><K><G><F><C><Y><V><E><F><D><E><V><D><S><L><K><E><A><L><T><Y><D><G><A><L><L><G><D><R><S><L><R><V><D><I><A><E><G><R><K><Q><D><K><G><G><F><G><F><R><K><G><G><P><D><D><R><G><M><G><S><S><R><E><S><R><G><G><W><D><S><R><D><D><F><N><S><G><F><R><D><D><F><L><G><G><R><G><G><S><R><P><G><D><R><R><T><G><P><P><M><G><S><R><F><R><D><G><P><P><L><R><G><S><N><M><D><F><R><E><P><T><E><E><E><R><A><Q><R><P><R><L><Q><L><K><P><R><T><V><A><T><P><L><N><Q><V><A><N><P><N><S><A><I><F><G><G><A><R><P><R><E><E><V><V><Q><K><E><Q><E> | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.<BOP> | Q15056 |
A0A0K0K1G6 | TVBJ3_HUMAN | T cell receptor beta variable 10-3 | Homo | <M><G><T><R><L><F><F><Y><V><A><L><C><L><L><W><T><G><H><M><D><A><G><I><T><Q><S><P><R><H><K><V><T><E><T><G><T><P><V><T><L><R><C><H><Q><T><E><N><H><R><Y><M><Y><W><Y><R><Q><D><P><G><H><G><L><R><L><I><H><Y><S><Y><G><V><K><D><T><D><K><G><E><V><S><D><G><Y><S><V><S><R><S><K><T><E><D><F><L><L><T><L><E><S><A><T><S><S><Q><T><S><V><Y><F><C><A><I><S><E> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0K0K1G6 |
Q9NRG0 | CHRC1_HUMAN | DNA polymerase epsilon subunit p15 | Homo | <M><A><D><V><V><V><G><K><D><K><G><G><E><Q><R><L><I><S><L><P><L><S><R><I><R><V><I><M><K><S><S><P><E><V><S><S><I><N><Q><E><A><L><V><L><T><A><K><A><T><E><L><F><V><Q><C><L><A><T><Y><S><Y><R><H><G><S><G><K><E><K><K><V><L><T><Y><S><D><L><A><N><T><A><Q><Q><S><E><T><F><Q><F><L><A><D><I><L><P><K><K><I><L><A><S><K><Y><L><K><M><L><K><E><E><K><R><E><E><D><E><E><N><D><N><D><N><E><S><D><H><D><E><A><D><S> | Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex .<BOP> | Q9NRG0 |
P49589 | SYCC_HUMAN | Cysteinyl-tRNA synthetase | Homo | <M><A><D><S><S><G><Q><Q><G><K><G><R><R><V><Q><P><Q><W><S><P><P><A><G><T><Q><P><C><R><L><H><L><Y><N><S><L><T><R><N><K><E><V><F><I><P><Q><D><G><K><K><V><T><W><Y><C><C><G><P><T><V><Y><D><A><S><H><M><G><H><A><R><S><Y><I><S><F><D><I><L><R><R><V><L><K><D><Y><F><K><F><D><V><F><Y><C><M><N><I><T><D><I><D><D><K><I><I><K><R><A><R><Q><N><H><L><F><E><Q><Y><R><E><K><R><P><E><A><A><Q><L><L><E><D><V><Q><A><A><L><K><P><F><S><V><K><L><N><E><T><T><D><P><D><K><K><Q><M><L><E><R><I><Q><H><A><V><Q><L><A><T><E><P><L><E><K><A><V><Q><S><R><L><T><G><E><E><V><N><S><C><V><E><V><L><L><E><E><A><K><D><L><L><S><D><W><L><D><S><T><L><G><C><D><V><T><D><N><S><I><F><S><K><L><P><K><F><W><E><G><D><F><H><R><D><M><E><A><L><N><V><L><P><P><D><V><L><T><R><V><S><E><Y><V><P><E><I><V><N><F><V><Q><K><I><V><D><N><G><Y><G><Y><V><S><N><G><S><V><Y><F><D><T><A><K><F><A><S><S><E><K><H><S><Y><G><K><L><V><P><E><A><V><G><D><Q><K><A><L><Q><E><G><E><G><D><L><S><I><S><A><D><R><L><S><E><K><R><S><P><N><D><F><A><L><W><K><A><S><K><P><G><E><P><S><W><P><C><P><W><G><K><G><R><P><G><W><H><I><E><C><S><A><M><A><G><T><L><L><G><A><S><M><D><I><H><G><G><G><F><D><L><R><F><P><H><H><D><N><E><L><A><Q><S><E><A><Y><F><E><N><D><C><W><V><R><Y><F><L><H><T><G><H><L><T><I><A><G><C><K><M><S><K><S><L><K><N><F><I><T><I><K><D><A><L><K><K><H><S><A><R><Q><L><R><L><A><F><L><M><H><S><W><K><D><T><L><D><Y><S><S><N><T><M><E><S><A><L><Q><Y><E><K><F><L><N><E><F><F><L><N><V><K><D><I><L><R><A><P><V><D><I><T><G><Q><F><E><K><W><G><E><E><E><A><E><L><N><K><N><F><Y><D><K><K><T><A><I><H><K><A><L><C><D><N><V><D><T><R><T><V><M><E><E><M><R><A><L><V><S><Q><C><N><L><Y><M><A><A><R><K><A><V><R><K><R><P><N><Q><A><L><L><E><N><I><A><L><Y><L><T><H><M><L><K><I><F><G><A><V><E><E><D><S><S><L><G><F><P><V><G><G><P><G><T><S><L><S><L><E><A><T><V><M><P><Y><L><Q><V><L><S><E><F><R><E><G><V><R><K><I><A><R><E><Q><K><V><P><E><I><L><Q><L><S><D><A><L><R><D><N><I><L><P><E><L><G><V><R><F><E><D><H><E><G><L><P><T><V><V><K><L><V><D><R><N><T><L><L><K><E><R><E><E><K><R><R><V><E><E><E><K><R><K><K><K><E><E><A><A><R><R><K><Q><E><Q><E><A><A><K><L><A><K><M><K><I><P><P><S><E><M><F><L><S><E><T><D><K><Y><S><K><F><D><E><N><G><L><P><T><H><D><M><E><G><K><E><L><S><K><G><Q><A><K><K><L><K><K><L><F><E><A><Q><E><K><L><Y><K><E><Y><L><Q><M><A><Q><N><G><S><F><Q> | Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).<BOP> | P49589 |
Q14439 | GP176_HUMAN | HB-954 | Homo | <M><G><H><N><G><S><W><I><S><P><N><A><S><E><P><H><N><A><S><G><A><E><A><A><G><V><N><R><S><A><L><G><E><F><G><E><A><Q><L><Y><R><Q><F><T><T><T><V><Q><V><V><I><F><I><G><S><L><L><G><N><F><M><V><L><W><S><T><C><R><T><T><V><F><K><S><V><T><N><R><F><I><K><N><L><A><C><S><G><I><C><A><S><L><V><C><V><P><F><D><I><I><L><S><T><S><P><H><C><C><W><W><I><Y><T><M><L><F><C><K><V><V><K><F><L><H><K><V><F><C><S><V><T><I><L><S><F><P><A><I><A><L><D><R><Y><Y><S><V><L><Y><P><L><E><R><K><I><S><D><A><K><S><R><E><L><V><M><Y><I><W><A><H><A><V><V><A><S><V><P><V><F><A><V><T><N><V><A><D><I><Y><A><T><S><T><C><T><E><V><W><S><N><S><L><G><H><L><V><Y><V><L><V><Y><N><I><T><T><V><I><V><P><V><V><V><V><F><L><F><L><I><L><I><R><R><A><L><S><A><S><Q><K><K><K><V><I><I><A><A><L><R><T><P><Q><N><T><I><S><I><P><Y><A><S><Q><R><E><A><E><L><H><A><T><L><L><S><M><V><M><V><F><I><L><C><S><V><P><Y><A><T><L><V><V><Y><Q><T><V><L><N><V><P><D><T><S><V><F><L><L><L><T><A><V><W><L><P><K><V><S><L><L><A><N><P><V><L><F><L><T><V><N><K><S><V><R><K><C><L><I><G><T><L><V><Q><L><H><H><R><Y><S><R><R><N><V><V><S><T><G><S><G><M><A><E><A><S><L><E><P><S><I><R><S><G><S><Q><L><L><E><M><F><H><I><G><Q><Q><Q><I><F><K><P><T><E><D><E><E><E><S><E><A><K><Y><I><G><S><A><D><F><Q><A><K><E><I><F><S><T><C><L><E><G><E><Q><G><P><Q><F><A><P><S><A><P><P><L><S><T><V><D><S><V><S><Q><V><A><P><A><A><P><V><E><P><E><T><F><P><D><K><Y><S><L><Q><F><G><F><G><P><F><E><L><P><P><Q><W><L><S><E><T><R><N><S><K><K><R><L><L><P><P><L><G><N><T><P><E><E><L><I><Q><T><K><V><P><K><V><G><R><V><E><R><K><M><S><R><N><N><K><V><S><I><F><P><K><V><D><S> | Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production.<BOP> | Q14439 |
Q9UDV6 | ZN212_HUMAN | Zinc finger protein C2H2-150 | Homo | <M><A><E><S><A><P><A><R><H><R><R><K><R><R><S><T><P><L><T><S><S><T><L><P><S><Q><A><T><E><K><S><S><Y><F><Q><T><T><E><I><S><L><W><T><V><V><A><A><I><Q><A><V><E><K><K><M><E><S><Q><A><A><R><L><Q><S><L><E><G><R><T><G><T><A><E><K><K><L><A><D><C><E><K><M><A><V><E><F><G><N><Q><L><E><G><K><W><A><V><L><G><T><L><L><Q><E><Y><G><L><L><Q><R><R><L><E><N><V><E><N><L><L><R><N><R><N><F><W><I><L><R><L><P><P><G><S><K><G><E><A><P><K><V><S><R><S><L><E><N><D><G><V><C><F><T><E><Q><E><W><E><N><L><E><D><W><Q><K><E><L><Y><R><N><V><M><E><S><N><Y><E><T><L><V><S><L><K><V><L><G><Q><T><E><G><E><A><E><L><G><T><E><M><L><G><D><L><E><E><E><G><P><G><G><A><H><P><A><G><G><V><M><I><K><Q><E><L><Q><Y><T><Q><E><G><P><A><D><L><P><G><E><F><S><C><I><A><E><E><Q><A><F><L><S><P><E><Q><T><E><L><W><G><G><Q><G><S><S><V><L><L><E><T><G><P><G><D><S><T><L><E><E><P><V><G><S><R><V><P><S><S><S><R><T><V><G><C><P><K><Q><K><S><H><R><Q><V><Q><L><D><Q><E><C><G><Q><G><L><K><L><K><K><D><T><S><R><P><Y><E><C><S><E><C><E><I><T><F><R><Y><K><Q><Q><L><A><T><H><L><R><S><H><S><G><W><G><S><C><T><P><E><E><P><E><E><S><L><R><P><R><P><R><L><K><P><Q><T><K><K><A><K><L><H><Q><C><D><V><C><L><R><S><F><S><C><K><V><S><L><V><T><H><Q><R><C><H><L><Q><E><G><P><S><A><G><Q><H><V><Q><E><R><F><S><P><N><S><L><V><A><L><P><G><H><I><P><W><R><K><S><R><S><S><L><I><C><G><Y><C><G><K><S><F><S><H><P><S><D><L><V><R><H><Q><R><I><H><T><G><E><R><P><Y><S><C><T><E><C><E><K><S><F><V><Q><K><Q><H><L><L><Q><H><Q><K><I><H><Q><R><E><R><G><G><L><A><L><E><P><G><R><P><N><G><L><L> | May be involved in transcriptional regulation.<BOP> | Q9UDV6 |
Q9NXX6 | NSE4A_HUMAN | Non-structural maintenance of chromosomes element 4 homolog A | Homo | <M><S><G><D><S><S><G><R><G><P><E><G><R><G><R><G><R><D><P><H><R><D><R><T><R><S><R><S><R><S><R><S><P><L><S><P><R><S><R><R><G><S><A><R><E><R><R><E><A><P><E><R><P><S><L><E><D><T><E><P><S><D><S><G><D><E><M><M><D><P><A><S><L><E><A><E><A><D><Q><G><L><C><R><Q><I><R><H><Q><Y><R><A><L><I><N><S><V><Q><Q><N><R><E><D><I><L><N><A><G><D><K><L><T><E><V><L><E><E><A><N><T><L><F><N><E><V><S><R><A><R><E><A><V><L><D><A><H><F><L><V><L><A><S><D><L><G><K><E><K><A><K><Q><L><R><S><D><L><S><S><F><D><M><L><R><Y><V><E><T><L><L><T><H><M><G><V><N><P><L><E><A><E><E><L><I><R><D><E><D><S><P><D><F><E><F><I><V><Y><D><S><W><K><I><T><G><R><T><A><E><N><T><F><N><K><T><H><T><F><H><F><L><L><G><S><I><Y><G><E><C><P><V><P><K><P><R><V><D><R><P><R><K><V><P><V><I><Q><E><E><R><A><M><P><A><Q><L><R><R><M><E><E><S><H><Q><E><A><T><E><K><E><V><E><R><I><L><G><L><L><Q><T><Y><F><R><E><D><P><D><T><P><M><S><F><F><D><F><V><V><D><P><H><S><F><P><R><T><V><E><N><I><F><H><V><S><F><I><I><R><D><G><F><A><R><I><R><L><D><Q><D><R><L><P><V><I><E><P><V><S><I><N><E><E><N><E><G><F><E><H><N><T><Q><V><R><N><Q><G><I><I><A><L><S><Y><R><D><W><E><E><I><V><K><T><F><E><I><S><E><P><V><I><T><P><S><Q><R><Q><Q><K><P><S><A> | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus.<BOP> | Q9NXX6 |
Q96FX7 | TRM61_HUMAN | tRNA(m1A58)-methyltransferase subunit TRMT61A | Homo | <M><S><F><V><A><Y><E><E><L><I><K><E><G><D><T><A><I><L><S><L><G><H><G><A><M><V><A><V><R><V><Q><R><G><A><Q><T><Q><T><R><H><G><V><L><R><H><S><V><D><L><I><G><R><P><F><G><S><K><V><T><C><G><R><G><G><W><V><Y><V><L><H><P><T><P><E><L><W><T><L><N><L><P><H><R><T><Q><I><L><Y><S><T><D><I><A><L><I><T><M><M><L><E><L><R><P><G><S><V><V><C><E><S><G><T><G><S><G><S><V><S><H><A><I><I><R><T><I><A><P><T><G><H><L><H><T><V><E><F><H><Q><Q><R><A><E><K><A><R><E><E><F><Q><E><H><R><V><G><R><W><V><T><V><R><T><Q><D><V><C><R><S><G><F><G><V><S><H><V><A><D><A><V><F><L><D><I><P><S><P><W><E><A><V><G><H><A><W><D><A><L><K><V><E><G><G><R><F><C><S><F><S><P><C><I><E><Q><V><Q><R><T><C><Q><A><L><A><A><R><G><F><S><E><L><S><T><L><E><V><L><P><Q><V><Y><N><V><R><T><V><S><L><P><P><P><D><L><G><T><G><T><D><G><P><A><G><S><D><T><S><P><F><R><S><G><T><P><M><K><E><A><V><G><H><T><G><Y><L><T><F><A><T><K><T><P><G> | Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA . Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries .<BOP> | Q96FX7 |
P47813 | IF1AX_HUMAN | Eukaryotic translation initiation factor 4C | Homo | <M><P><K><N><K><G><K><G><G><K><N><R><R><R><G><K><N><E><N><E><S><E><K><R><E><L><V><F><K><E><D><G><Q><E><Y><A><Q><V><I><K><M><L><G><N><G><R><L><E><A><M><C><F><D><G><V><K><R><L><C><H><I><R><G><K><L><R><K><K><V><W><I><N><T><S><D><I><I><L><V><G><L><R><D><Y><Q><D><N><K><A><D><V><I><L><K><Y><N><A><D><E><A><R><S><L><K><A><Y><G><E><L><P><E><H><A><K><I><N><E><T><D><T><F><G><P><G><D><D><D><E><I><Q><F><D><D><I><G><D><D><D><E><D><I><D><D><I> | Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.<BOP> | P47813 |
Q8N118 | CP4X1_HUMAN | CYPIVX1 | Homo | <M><E><F><S><W><L><E><T><R><W><A><R><P><F><Y><L><A><F><V><F><C><L><A><L><G><L><L><Q><A><I><K><L><Y><L><R><R><Q><R><L><L><R><D><L><R><P><F><P><A><P><P><T><H><W><F><L><G><H><Q><K><F><I><Q><D><D><N><M><E><K><L><E><E><I><I><E><K><Y><P><R><A><F><P><F><W><I><G><P><F><Q><A><F><F><C><I><Y><D><P><D><Y><A><K><T><L><L><S><R><T><D><P><K><S><Q><Y><L><Q><K><F><S><P><P><L><L><G><K><G><L><A><A><L><D><G><P><K><W><F><Q><H><R><R><L><L><T><P><G><F><H><F><N><I><L><K><A><Y><I><E><V><M><A><H><S><V><K><M><M><L><D><K><W><E><K><I><C><S><T><Q><D><T><S><V><E><V><Y><E><H><I><N><S><M><S><L><D><I><I><M><K><C><A><F><S><K><E><T><N><C><Q><T><N><S><T><H><D><P><Y><A><K><A><I><F><E><L><S><K><I><I><F><H><R><L><Y><S><L><L><Y><H><S><D><I><I><F><K><L><S><P><Q><G><Y><R><F><Q><K><L><S><R><V><L><N><Q><Y><T><D><T><I><I><Q><E><R><K><K><S><L><Q><A><G><V><K><Q><D><N><T><P><K><R><K><Y><Q><D><F><L><D><I><V><L><S><A><K><D><E><S><G><S><S><F><S><D><I><D><V><H><S><E><V><S><T><F><L><L><A><G><H><D><T><L><A><A><S><I><S><W><I><L><Y><C><L><A><L><N><P><E><H><Q><E><R><C><R><E><E><V><R><G><I><L><G><D><G><S><S><I><T><W><D><Q><L><G><E><M><S><Y><T><T><M><C><I><K><E><T><C><R><L><I><P><A><V><P><S><I><S><R><D><L><S><K><P><L><T><F><P><D><G><C><T><L><P><A><G><I><T><V><V><L><S><I><W><G><L><H><H><N><P><A><V><W><K><N><P><K><V><F><D><P><L><R><F><S><Q><E><N><S><D><Q><R><H><P><Y><A><Y><L><P><F><S><A><G><S><R><N><C><I><G><Q><E><F><A><M><I><E><L><K><V><T><I><A><L><I><L><L><H><F><R><V><T><P><D><P><T><R><P><L><T><F><P><N><H><F><I><L><K><P><K><N><G><M><Y><L><H><L><K><K><L><S><E><C> | A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).<BOP> | Q8N118 |
Q9BZK7 | TBL1R_HUMAN | Transducin beta-like 1X-related protein 1 | Homo | <M><S><I><S><S><D><E><V><N><F><L><V><Y><R><Y><L><Q><E><S><G><F><S><H><S><A><F><T><F><G><I><E><S><H><I><S><Q><S><N><I><N><G><A><L><V><P><P><A><A><L><I><S><I><I><Q><K><G><L><Q><Y><V><E><A><E><V><S><I><N><E><D><G><T><L><F><D><G><R><P><I><E><S><L><S><L><I><D><A><V><M><P><D><V><V><Q><T><R><Q><Q><A><Y><R><D><K><L><A><Q><Q><Q><A><A><A><A><A><A><A><A><A><A><A><S><Q><Q><G><S><A><K><N><G><E><N><T><A><N><G><E><E><N><G><A><H><T><I><A><N><N><H><T><D><M><M><E><V><D><G><D><V><E><I><P><P><N><K><A><V><V><L><R><G><H><E><S><E><V><F><I><C><A><W><N><P><V><S><D><L><L><A><S><G><S><G><D><S><T><A><R><I><W><N><L><S><E><N><S><T><S><G><S><T><Q><L><V><L><R><H><C><I><R><E><G><G><Q><D><V><P><S><N><K><D><V><T><S><L><D><W><N><S><E><G><T><L><L><A><T><G><S><Y><D><G><F><A><R><I><W><T><K><D><G><N><L><A><S><T><L><G><Q><H><K><G><P><I><F><A><L><K><W><N><K><K><G><N><F><I><L><S><A><G><V><D><K><T><T><I><I><W><D><A><H><T><G><E><A><K><Q><Q><F><P><F><H><S><A><P><A><L><D><V><D><W><Q><S><N><N><T><F><A><S><C><S><T><D><M><C><I><H><V><C><K><L><G><Q><D><R><P><I><K><T><F><Q><G><H><T><N><E><V><N><A><I><K><W><D><P><T><G><N><L><L><A><S><C><S><D><D><M><T><L><K><I><W><S><M><K><Q><D><N><C><V><H><D><L><Q><A><H><N><K><E><I><Y><T><I><K><W><S><P><T><G><P><G><T><N><N><P><N><A><N><L><M><L><A><S><A><S><F><D><S><T><V><R><L><W><D><V><D><R><G><I><C><I><H><T><L><T><K><H><Q><E><P><V><Y><S><V><A><F><S><P><D><G><R><Y><L><A><S><G><S><F><D><K><C><V><H><I><W><N><T><Q><T><G><A><L><V><H><S><Y><R><G><T><G><G><I><F><E><V><C><W><N><A><A><G><D><K><V><G><A><S><A><S><D><G><S><V><C><V><L><D><L><R><K> | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.<BOP> | Q9BZK7 |
Q9Y388 | RBMX2_HUMAN | RNA-binding motif protein, X-linked 2 | Homo | <M><N><P><L><T><K><V><K><L><I><N><E><L><N><E><R><E><V><Q><L><G><V><A><D><K><V><S><W><H><S><E><Y><K><D><S><A><W><I><F><L><G><G><L><P><Y><E><L><T><E><G><D><I><I><C><V><F><S><Q><Y><G><E><I><V><N><I><N><L><V><R><D><K><K><T><G><K><S><K><G><F><C><F><L><C><Y><E><D><Q><R><S><T><I><L><A><V><D><N><F><N><G><I><K><I><K><G><R><T><I><R><V><D><H><V><S><N><Y><R><A><P><K><D><S><E><E><I><D><D><V><T><R><Q><L><Q><E><K><G><C><G><A><R><T><P><S><P><S><L><S><E><S><S><E><D><E><K><P><T><K><K><H><K><K><D><K><K><E><K><K><K><K><K><K><E><K><E><K><A><D><R><E><V><Q><A><E><Q><P><S><S><S><S><P><R><R><K><T><V><K><E><K><D><D><T><G><P><K><K><H><S><S><K><N><S><E><R><A><Q><K><S><E><P><R><E><G><Q><K><L><P><K><S><R><T><A><Y><S><G><G><A><E><D><L><E><R><E><L><K><K><E><K><P><K><H><E><H><K><S><S><S><R><R><E><A><R><E><E><K><T><R><I><R><D><R><G><R><S><S><D><A><H><S><S><W><Y><N><G><R><S><E><G><R><S><Y><R><S><R><S><R><S><R><D><K><S><H><R><H><K><R><A><R><R><S><R><E><R><E><S><S><N><P><S><D><R><W><R><H> | Involved in pre-mRNA splicing as component of the activated spliceosome.<BOP> | Q9Y388 |
Q8IYD9 | LAS2_HUMAN | Lung adenoma susceptibility protein 2 | Homo | <M><A><K><S><K><T><K><H><R><L><C><S><Q><E><S><S><V><S><A><L><L><A><S><C><T><L><S><G><S><N><S><S><N><S><D><G><S><F><H><Y><K><D><K><L><Y><R><S><A><S><Q><A><L><Q><A><Y><I><D><D><F><D><L><G><Q><I><Y><P><G><A><S><T><G><K><I><N><I><D><E><D><F><T><N><M><S><Q><F><C><N><Y><I><Y><K><P><N><N><A><F><E><N><L><D><H><K><K><H><S><N><F><I><S><C><R><R><H><T><V><N><D><I><D><S><M><S><L><T><T><D><D><L><L><R><L><P><A><D><G><S><F><S><Y><T><Y><V><G><P><S><H><R><T><S><K><K><N><K><K><C><R><G><R><L><G><S><L><D><I><E><K><N><P><H><F><Q><G><P><Y><T><S><M><G><K><D><N><F><V><T><P><V><I><R><S><N><I><N><G><K><Q><C><G><D><K><I><E><L><L><I><L><K><A><K><R><N><L><E><Q><C><T><E><E><L><P><K><S><M><K><K><D><D><S><P><C><S><L><D><K><L><E><A><D><R><S><W><E><N><I><P><V><T><F><K><S><P><V><P><V><N><S><D><D><S><P><Q><Q><T><S><R><A><K><S><A><K><G><V><L><E><D><F><L><N><N><D><N><Q><S><C><T><L><S><G><G><K><H><H><G><P><V><E><A><L><K><Q><M><L><F><N><L><Q><A><V><Q><E><R><F><N><Q><N><K><T><T><D><P><K><E><E><I><K><Q><V><S><E><D><D><F><S><K><L><Q><L><K><E><S><M><I><P><I><T><R><S><L><Q><K><A><L><H><H><L><S><R><L><R><D><L><V><D><D><T><N><G><E><R><S><P><K><M> | Might play a role in cell proliferation.<BOP> | Q8IYD9 |
Q5BKY1 | LRC10_HUMAN | Leucine-rich repeat-containing protein 10 | Homo | <M><G><N><T><I><R><A><L><V><A><F><I><P><A><D><R><C><Q><N><Y><V><V><R><D><L><R><E><M><P><L><D><K><M><V><D><L><S><G><S><Q><L><R><R><F><P><L><H><V><C><S><F><R><E><L><V><K><L><Y><L><S><D><N><H><L><N><S><L><P><P><E><L><G><Q><L><Q><N><L><Q><I><L><A><L><D><F><N><N><F><K><A><L><P><Q><V><V><C><T><L><K><Q><L><C><I><L><Y><L><G><N><N><K><L><C><D><L><P><S><E><L><S><L><L><Q><N><L><R><T><L><W><I><E><A><N><C><L><T><Q><L><P><D><V><V><C><E><L><S><L><L><K><T><L><H><A><G><S><N><A><L><R><L><L><P><G><Q><L><R><R><L><Q><E><L><R><T><I><W><L><S><G><N><R><L><T><D><F><P><T><V><L><L><H><M><P><F><L><E><V><I><D><V><D><W><N><S><I><R><Y><F><P><S><L><A><H><L><S><S><L><K><L><V><I><Y><D><H><N><P><C><R><N><A><P><K><V><A><K><G><V><R><R><V><G><R><W><A><E><E><T><P><E><P><D><P><R><K><A><R><R><Y><A><L><V><R><E><E><S><Q><E><L><Q><A><P><V><P><L><L><P><P><T><N><S> | May play important roles in cardiac development and/or cardiac function.<BOP> | Q5BKY1 |
Q9HC57 | WFDC1_HUMAN | ps20 growth inhibitor | Homo | <M><P><L><T><G><V><G><P><G><S><C><R><R><Q><I><I><R><A><L><C><L><L><L><L><L><L><H><A><G><S><A><K><N><I><W><K><R><A><L><P><A><R><L><A><E><K><S><R><A><E><E><A><G><A><P><G><G><P><R><Q><P><R><A><D><R><C><P><P><P><P><R><T><L><P><P><G><A><C><Q><A><A><R><C><Q><A><D><S><E><C><P><R><H><R><R><C><C><Y><N><G><C><A><Y><A><C><L><E><A><V><P><P><P><P><V><L><D><W><L><V><Q><P><K><P><R><W><L><G><G><N><G><W><L><L><D><G><P><E><E><V><L><Q><A><E><A><C><S><T><T><E><D><G><A><E><P><L><L><C><P><S><G><Y><E><C><H><I><L><S><P><G><D><V><A><E><G><I><P><N><R><G><Q><C><V><K><Q><R><R><Q><A><D><G><R><I><L><R><H><K><L><Y><K><E><Y><P><E><G><D><S><K><N><V><A><E><P><G><R><G><Q><Q><K><H><F><Q> | Has growth inhibitory activity.<BOP> | Q9HC57 |
Q86TL2 | STIMA_HUMAN | Transmembrane protein 110 | Homo | <M><Q><G><P><A><G><N><A><S><R><G><L><P><G><G><P><P><S><T><V><A><S><G><A><G><R><C><E><S><G><A><L><M><H><S><F><G><I><F><L><Q><G><L><L><G><V><V><A><F><S><T><L><M><L><K><R><F><R><E><P><K><H><E><R><R><P><W><R><I><W><F><L><D><T><S><K><Q><A><I><G><M><L><F><I><H><F><A><N><V><Y><L><A><D><L><T><E><E><D><P><C><S><L><Y><L><I><N><F><L><L><D><A><T><V><G><M><L><L><I><Y><V><G><V><R><A><V><S><V><L><V><E><W><Q><Q><W><E><S><L><R><F><G><E><Y><G><D><P><L><Q><C><G><A><W><V><G><Q><C><A><L><Y><I><V><I><M><I><F><E><K><S><V><V><F><I><V><L><L><I><L><Q><W><K><K><V><A><L><L><N><P><I><E><N><P><D><L><K><L><A><I><V><M><L><I><V><P><F><F><V><N><A><L><M><F><W><V><V><D><N><F><L><M><R><K><G><K><T><K><A><K><L><E><E><R><G><A><N><Q><D><S><R><N><G><S><K><V><R><Y><R><R><A><A><S><H><E><E><S><E><S><E><I><L><I><S><A><D><D><E><M><E><E><S><D><V><E><E><D><L><R><R><L><T><P><L><K><P><V><K><K><K><K><H><R><F><G><L><P><V> | Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER . SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores . Acts by interacting with STIM1, promoting STIM1 conformational switch . Involved in STIM1 relocalization to ER-PM junctions . Contributes to the maintenance and reorganization of store-dependent ER-PM junctions .<BOP> | Q86TL2 |
Q8NGC0 | O5AU1_HUMAN | Olfactory receptor OR14-38 | Homo | <M><T><E><F><H><L><Q><S><Q><M><P><S><I><R><L><I><F><R><R><L><S><L><G><R><I><K><P><S><Q><S><P><R><C><S><T><S><F><M><V><V><P><S><F><S><I><A><E><H><W><R><R><M><K><G><A><N><L><S><Q><G><M><E><F><E><L><L><G><L><T><T><D><P><Q><L><Q><R><L><L><F><V><V><F><L><G><M><Y><T><A><T><L><L><G><N><L><V><M><F><L><L><I><H><V><S><A><T><L><H><T><P><M><Y><S><L><L><K><S><L><S><F><L><D><F><C><Y><S><S><T><V><V><P><Q><T><L><V><N><F><L><A><K><R><K><V><I><S><Y><F><G><C><M><T><Q><M><F><F><Y><A><G><F><A><T><S><E><C><Y><L><I><A><A><M><A><Y><D><R><Y><A><A><I><C><N><P><L><L><Y><S><T><I><M><S><P><E><V><C><A><S><L><I><V><G><S><Y><S><A><G><F><L><N><S><L><I><H><T><G><C><I><F><S><L><K><F><C><G><A><H><V><V><T><H><F><F><C><D><G><P><P><I><L><S><L><S><C><V><D><T><S><L><C><E><I><L><L><F><I><F><A><G><F><N><L><L><S><C><T><L><T><I><L><I><S><Y><F><L><I><L><N><T><I><L><K><M><S><S><A><Q><G><R><F><K><A><F><S><T><C><A><S><H><L><T><A><I><C><L><F><F><G><T><T><L><F><M><Y><L><R><P><R><S><S><Y><S><L><T><Q><D><R><T><V><A><V><I><Y><T><V><V><I><P><V><L><N><P><L><M><Y><S><L><R><N><K><D><V><K><K><A><L><I><K><V><W><G><R><K><T><M><E> | Odorant receptor.<BOP> | Q8NGC0 |
Q92643 | GPI8_HUMAN | Phosphatidylinositol-glycan biosynthesis class K protein | Homo | <M><A><V><T><D><S><L><S><R><A><A><T><V><L><A><T><V><L><L><L><S><F><G><S><V><A><A><S><H><I><E><D><Q><A><E><Q><F><F><R><S><G><H><T><N><N><W><A><V><L><V><C><T><S><R><F><W><F><N><Y><R><H><V><A><N><T><L><S><V><Y><R><S><V><K><R><L><G><I><P><D><S><H><I><V><L><M><L><A><D><D><M><A><C><N><P><R><N><P><K><P><A><T><V><F><S><H><K><N><M><E><L><N><V><Y><G><D><D><V><E><V><D><Y><R><S><Y><E><V><T><V><E><N><F><L><R><V><L><T><G><R><I><P><P><S><T><P><R><S><K><R><L><L><S><D><D><R><S><N><I><L><I><Y><M><T><G><H><G><G><N><G><F><L><K><F><Q><D><S><E><E><I><T><N><I><E><L><A><D><A><F><E><Q><M><W><Q><K><R><R><Y><N><E><L><L><F><I><I><D><T><C><Q><G><A><S><M><Y><E><R><F><Y><S><P><N><I><M><A><L><A><S><S><Q><V><G><E><D><S><L><S><H><Q><P><D><P><A><I><G><V><H><L><M><D><R><Y><T><F><Y><V><L><E><F><L><E><E><I><N><P><A><S><Q><T><N><M><N><D><L><F><Q><V><C><P><K><S><L><C><V><S><T><P><G><H><R><T><D><L><F><Q><R><D><P><K><N><V><L><I><T><D><F><F><G><S><V><R><K><V><E><I><T><T><E><T><I><K><L><Q><Q><D><S><E><I><M><E><S><S><Y><K><E><D><Q><M><D><E><K><L><M><E><P><L><K><Y><A><E><Q><L><P><V><A><Q><I><I><H><Q><K><P><K><L><K><D><W><H><P><P><G><G><F><I><L><G><L><W><A><L><I><I><M><V><F><F><K><T><Y><G><I><K><H><M><K><F><I><F> | Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.<BOP> | Q92643 |
P58499 | FAM3B_HUMAN | Pancreatic-derived factor | Homo | <M><R><P><L><A><G><G><L><L><K><V><V><F><V><V><F><A><S><L><C><A><W><Y><S><G><Y><L><L><A><E><L><I><P><D><A><P><L><S><S><A><A><Y><S><I><R><S><I><G><E><R><P><V><L><K><A><P><V><P><K><R><Q><K><C><D><H><W><T><P><C><P><S><D><T><Y><A><Y><R><L><L><S><G><G><G><R><S><K><Y><A><K><I><C><F><E><D><N><L><L><M><G><E><Q><L><G><N><V><A><R><G><I><N><I><A><I><V><N><Y><V><T><G><N><V><T><A><T><R><C><F><D><M><Y><E><G><D><N><S><G><P><M><T><K><F><I><Q><S><A><A><P><K><S><L><L><F><M><V><T><Y><D><D><G><S><T><R><L><N><N><D><A><K><N><A><I><E><A><L><G><S><K><E><I><R><N><M><K><F><R><S><S><W><V><F><I><A><A><K><G><L><E><L><P><S><E><I><Q><R><E><K><I><N><H><S><D><A><K><N><N><R><Y><S><G><W><P><A><E><I><Q><I><E><G><C><I><P><K><E><R><S> | Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.<BOP> | P58499 |
P22674 | CCNO_HUMAN | Cyclin-O | Homo | <M><V><T><P><C><P><T><S><P><S><S><P><A><A><R><A><G><R><R><D><N><D><Q><N><L><R><A><P><V><K><K><S><R><R><P><R><L><R><R><K><Q><P><L><H><P><L><N><P><C><P><L><P><G><D><S><G><I><C><D><L><F><E><S><P><S><S><G><S><D><G><A><E><S><P><S><A><A><R><G><G><S><P><L><P><G><P><A><Q><P><V><A><Q><L><D><L><Q><T><F><R><D><Y><G><Q><S><C><Y><A><F><R><K><A><Q><E><S><H><F><H><P><R><E><A><L><A><R><Q><P><Q><V><T><A><E><S><R><C><K><L><L><S><W><L><I><P><V><H><R><Q><F><G><L><S><F><E><S><L><C><L><T><V><N><T><L><D><R><F><L><T><T><T><P><V><A><A><D><C><F><Q><L><L><G><V><T><S><L><L><I><A><C><K><Q><V><E><V><H><P><P><R><V><K><Q><L><L><A><L><C><C><G><A><F><S><R><Q><Q><L><C><N><L><E><C><I><V><L><H><K><L><H><F><T><L><G><A><P><T><I><S><F><F><L><E><H><F><T><H><A><R><V><E><A><G><Q><A><E><A><S><E><A><L><E><A><Q><A><L><A><R><G><V><A><E><L><S><L><A><D><Y><A><F><T><S><Y><S><P><S><L><L><A><I><C><C><L><A><L><A><D><R><M><L><R><V><S><R><P><V><D><L><R><L><G><D><H><P><E><A><A><L><E><D><C><M><G><K><L><Q><L><L><V><A><I><N><S><T><S><L><T><H><M><L><P><V><Q><I><C><E><K><C><S><L><P><P><S><S><K> | Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.<BOP> | P22674 |
O96001 | PPR17_HUMAN | G-substrate | Homo | <M><M><S><T><E><Q><M><Q><P><L><E><L><S><E><D><R><L><D><K><L><D><P><R><C><S><H><L><D><D><L><S><D><Q><F><I><K><D><C><D><L><K><K><K><P><R><K><G><K><N><V><Q><A><T><L><N><V><E><S><D><Q><K><K><P><R><R><K><D><T><P><A><L><H><I><P><P><F><I><P><G><V><F><S><E><H><L><I><K><R><Y><D><V><Q><E><R><H><P><K><G><K><M><I><P><V><L><H><N><T><D><L><E><Q><K><K><P><R><R><K><D><T><P><A><L><H><M><S><P><F><A><A><G><V><T><L><L><R><D><E><R><P><K><A><I><V><E><D><D><E><K><D><G><D><K><I><A><I> | Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.<BOP> | O96001 |
P78423 | X3CL1_HUMAN | Processed fractalkine | Homo | <M><A><P><I><S><L><S><W><L><L><R><L><A><T><F><C><H><L><T><V><L><L><A><G><Q><H><H><G><V><T><K><C><N><I><T><C><S><K><M><T><S><K><I><P><V><A><L><L><I><H><Y><Q><Q><N><Q><A><S><C><G><K><R><A><I><I><L><E><T><R><Q><H><R><L><F><C><A><D><P><K><E><Q><W><V><K><D><A><M><Q><H><L><D><R><Q><A><A><A><L><T><R><N><G><G><T><F><E><K><Q><I><G><E><V><K><P><R><T><T><P><A><A><G><G><M><D><E><S><V><V><L><E><P><E><A><T><G><E><S><S><S><L><E><P><T><P><S><S><Q><E><A><Q><R><A><L><G><T><S><P><E><L><P><T><G><V><T><G><S><S><G><T><R><L><P><P><T><P><K><A><Q><D><G><G><P><V><G><T><E><L><F><R><V><P><P><V><S><T><A><A><T><W><Q><S><S><A><P><H><Q><P><G><P><S><L><W><A><E><A><K><T><S><E><A><P><S><T><Q><D><P><S><T><Q><A><S><T><A><S><S><P><A><P><E><E><N><A><P><S><E><G><Q><R><V><W><G><Q><G><Q><S><P><R><P><E><N><S><L><E><R><E><E><M><G><P><V><P><A><H><T><D><A><F><Q><D><W><G><P><G><S><M><A><H><V><S><V><V><P><V><S><S><E><G><T><P><S><R><E><P><V><A><S><G><S><W><T><P><K><A><E><E><P><I><H><A><T><M><D><P><Q><R><L><G><V><L><I><T><P><V><P><D><A><Q><A><A><T><R><R><Q><A><V><G><L><L><A><F><L><G><L><L><F><C><L><G><V><A><M><F><T><Y><Q><S><L><Q><G><C><P><R><K><M><A><G><E><M><A><E><G><L><R><Y><I><P><R><S><C><G><S><N><S><Y><V><L><V><P><V> | The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.<BOP> | P78423 |
Q12946 | FOXF1_HUMAN | Forkhead-related transcription factor 1 | Homo | <M><S><S><A><P><E><K><Q><Q><P><P><H><G><G><G><G><G><G><G><G><G><G><G><A><A><M><D><P><A><S><S><G><P><S><K><A><K><K><T><N><A><G><I><R><R><P><E><K><P><P><Y><S><Y><I><A><L><I><V><M><A><I><Q><S><S><P><T><K><R><L><T><L><S><E><I><Y><Q><F><L><Q><S><R><F><P><F><F><R><G><S><Y><Q><G><W><K><N><S><V><R><H><N><L><S><L><N><E><C><F><I><K><L><P><K><G><L><G><R><P><G><K><G><H><Y><W><T><I><D><P><A><S><E><F><M><F><E><E><G><S><F><R><R><R><P><R><G><F><R><R><K><C><Q><A><L><K><P><M><Y><S><M><M><N><G><L><G><F><N><H><L><P><D><T><Y><G><F><Q><G><S><A><G><G><L><S><C><P><P><N><S><L><A><L><E><G><G><L><G><M><M><N><G><H><L><P><G><N><V><D><G><M><A><L><P><S><H><S><V><P><H><L><P><S><N><G><G><H><S><Y><M><G><G><C><G><G><A><A><A><G><E><Y><P><H><H><D><S><S><V><P><A><S><P><L><L><P><T><G><A><G><G><V><M><E><P><H><A><V><Y><S><G><S><A><A><A><W><P><P><S><A><S><A><A><L><N><S><G><A><S><Y><I><K><Q><Q><P><L><S><P><C><N><P><A><A><N><P><L><S><G><S><L><S><T><H><S><L><E><Q><P><Y><L><H><Q><N><S><H><N><A><P><A><E><L><Q><G><I><P><R><Y><H><S><Q><S><P><S><M><C><D><R><K><E><F><V><F><S><F><N><A><M><A><S><S><S><M><H><S><A><G><G><G><S><Y><Y><H><Q><Q><V><T><Y><Q><D><I><K><P><C><V><M> | Probable transcription activator for a number of lung-specific genes.<BOP> | Q12946 |
Q5QJ74 | TBCEL_HUMAN | Leucine-rich repeat-containing protein 35 | Homo | <M><D><Q><P><S><G><R><S><F><M><Q><V><L><C><E><K><Y><S><P><E><N><F><P><Y><R><R><G><P><G><M><G><V><H><V><P><A><T><P><Q><G><S><P><M><K><D><R><L><N><L><P><S><V><L><V><L><N><S><C><G><I><T><C><A><G><D><E><K><E><I><A><A><F><C><A><H><V><S><E><L><D><L><S><D><N><K><L><E><D><W><H><E><V><S><K><I><V><S><N><V><P><Q><L><E><F><L><N><L><S><S><N><P><L><N><L><S><V><L><E><R><T><C><A><G><S><F><S><G><V><R><K><L><V><L><N><N><S><K><A><S><W><E><T><V><H><M><I><L><Q><E><L><P><D><L><E><E><L><F><L><C><L><N><D><Y><E><T><V><S><C><P><S><I><C><C><H><S><L><K><L><L><H><I><T><D><N><N><L><Q><D><W><T><E><I><R><K><L><G><V><M><F><P><S><L><D><T><L><V><L><A><N><N><H><L><N><A><I><E><E><P><D><D><S><L><A><R><L><F><P><N><L><R><S><I><S><L><H><K><S><G><L><Q><S><W><E><D><I><D><K><L><N><S><F><P><K><L><E><E><V><R><L><L><G><I><P><L><L><Q><P><Y><T><T><E><E><R><R><K><L><V><I><A><R><L><P><S><V><S><K><L><N><G><S><V><V><T><D><G><E><R><E><D><S><E><R><F><F><I><R><Y><Y><V><D><V><P><Q><E><E><V><P><F><R><Y><H><E><L><I><T><K><Y><G><K><L><E><P><L><A><E><V><D><L><R><P><Q><S><S><A><K><V><E><V><H><F><N><D><Q><V><E><E><M><S><I><R><L><D><Q><T><V><A><E><L><K><K><Q><L><K><T><L><V><Q><L><P><T><S><N><M><L><L><Y><Y><F><D><H><E><A><P><F><G><P><E><E><M><K><Y><S><S><R><A><L><H><S><F><G><I><R><D><G><D><K><I><Y><V><E><S><K><T><K> | Acts as a regulator of tubulin stability.<BOP> | Q5QJ74 |
Q6P2I3 | FAH2B_HUMAN | Fumarylacetoacetate hydrolase domain-containing protein 2B | Homo | <M><L><V><S><G><R><R><R><L><L><T><A><L><L><Q><A><Q><K><W><P><F><Q><P><S><R><D><M><R><L><V><Q><F><R><A><P><H><L><V><G><P><H><L><G><L><E><T><G><N><G><G><G><V><I><N><L><N><A><F><D><P><T><L><P><K><T><M><T><Q><F><L><E><Q><G><E><A><T><L><S><V><A><R><R><A><L><A><A><Q><L><P><V><L><P><W><S><E><V><T><F><L><A><P><V><T><W><P><D><K><V><V><C><V><G><M><N><Y><V><D><H><C><K><E><Q><N><V><P><V><P><K><E><P><I><I><F><S><K><F><A><S><S><I><V><G><P><Y><D><E><V><V><L><P><P><Q><S><Q><E><V><D><W><E><V><E><L><A><V><V><I><G><K><K><G><K><H><I><K><A><T><D><A><M><A><H><V><A><G><F><T><V><A><H><D><V><S><A><R><D><W><L><T><R><R><N><G><K><Q><W><L><L><G><K><T><F><D><T><F><C><P><L><G><P><A><L><V><T><K><D><S><V><A><D><P><H><N><L><K><I><C><C><R><V><N><G><E><V><V><Q><S><S><N><T><N><Q><M><V><F><K><T><E><D><L><I><A><W><V><S><Q><F><V><T><F><Y><P><G><D><V><I><L><T><G><T><P><P><G><V><G><V><F><R><K><P><P><V><F><L><K><K><G><D><E><V><Q><C><E><I><E><E><L><G><V><I><I><N><K><V><V> | May have hydrolase activity.<BOP> | Q6P2I3 |
P11511 | CP19A_HUMAN | Estrogen synthase | Homo | <M><V><L><E><M><L><N><P><I><H><Y><N><I><T><S><I><V><P><E><A><M><P><A><A><T><M><P><V><L><L><L><T><G><L><F><L><L><V><W><N><Y><E><G><T><S><S><I><P><G><P><G><Y><C><M><G><I><G><P><L><I><S><H><G><R><F><L><W><M><G><I><G><S><A><C><N><Y><Y><N><R><V><Y><G><E><F><M><R><V><W><I><S><G><E><E><T><L><I><I><S><K><S><S><S><M><F><H><I><M><K><H><N><H><Y><S><S><R><F><G><S><K><L><G><L><Q><C><I><G><M><H><E><K><G><I><I><F><N><N><N><P><E><L><W><K><T><T><R><P><F><F><M><K><A><L><S><G><P><G><L><V><R><M><V><T><V><C><A><E><S><L><K><T><H><L><D><R><L><E><E><V><T><N><E><S><G><Y><V><D><V><L><T><L><L><R><R><V><M><L><D><T><S><N><T><L><F><L><R><I><P><L><D><E><S><A><I><V><V><K><I><Q><G><Y><F><D><A><W><Q><A><L><L><I><K><P><D><I><F><F><K><I><S><W><L><Y><K><K><Y><E><K><S><V><K><D><L><K><D><A><I><E><V><L><I><A><E><K><R><R><R><I><S><T><E><E><K><L><E><E><C><M><D><F><A><T><E><L><I><L><A><E><K><R><G><D><L><T><R><E><N><V><N><Q><C><I><L><E><M><L><I><A><A><P><D><T><M><S><V><S><L><F><F><M><L><F><L><I><A><K><H><P><N><V><E><E><A><I><I><K><E><I><Q><T><V><I><G><E><R><D><I><K><I><D><D><I><Q><K><L><K><V><M><E><N><F><I><Y><E><S><M><R><Y><Q><P><V><V><D><L><V><M><R><K><A><L><E><D><D><V><I><D><G><Y><P><V><K><K><G><T><N><I><I><L><N><I><G><R><M><H><R><L><E><F><F><P><K><P><N><E><F><T><L><E><N><F><A><K><N><V><P><Y><R><Y><F><Q><P><F><G><F><G><P><R><G><C><A><G><K><Y><I><A><M><V><M><M><K><A><I><L><V><T><L><L><R><R><F><H><V><K><T><L><Q><G><Q><C><V><E><S><I><Q><K><I><H><D><L><S><L><H><P><D><E><T><K><N><M><L><E><M><I><F><T><P><R><N><S><D><R><C><L><E><H> | A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively . Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid . Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen . Also displays 2-hydroxylase activity toward estrone . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome | P11511 |
P07320 | CRGD_HUMAN | Gamma-crystallin 4 | Homo | <M><G><K><I><T><L><Y><E><D><R><G><F><Q><G><R><H><Y><E><C><S><S><D><H><P><N><L><Q><P><Y><L><S><R><C><N><S><A><R><V><D><S><G><C><W><M><L><Y><E><Q><P><N><Y><S><G><L><Q><Y><F><L><R><R><G><D><Y><A><D><H><Q><Q><W><M><G><L><S><D><S><V><R><S><C><R><L><I><P><H><S><G><S><H><R><I><R><L><Y><E><R><E><D><Y><R><G><Q><M><I><E><F><T><E><D><C><S><C><L><Q><D><R><F><R><F><N><E><I><H><S><L><N><V><L><E><G><S><W><V><L><Y><E><L><S><N><Y><R><G><R><Q><Y><L><L><M><P><G><D><Y><R><R><Y><Q><D><W><G><A><T><N><A><R><V><G><S><L><R><R><V><I><D><F><S> | Crystallins are the dominant structural components of the vertebrate eye lens.<BOP> | P07320 |
P28845 | DHI1_HUMAN | Short chain dehydrogenase/reductase family 26C member 1 | Homo | <M><A><F><M><K><K><Y><L><L><P><I><L><G><L><F><M><A><Y><Y><Y><Y><S><A><N><E><E><F><R><P><E><M><L><Q><G><K><K><V><I><V><T><G><A><S><K><G><I><G><R><E><M><A><Y><H><L><A><K><M><G><A><H><V><V><V><T><A><R><S><K><E><T><L><Q><K><V><V><S><H><C><L><E><L><G><A><A><S><A><H><Y><I><A><G><T><M><E><D><M><T><F><A><E><Q><F><V><A><Q><A><G><K><L><M><G><G><L><D><M><L><I><L><N><H><I><T><N><T><S><L><N><L><F><H><D><D><I><H><H><V><R><K><S><M><E><V><N><F><L><S><Y><V><V><L><T><V><A><A><L><P><M><L><K><Q><S><N><G><S><I><V><V><V><S><S><L><A><G><K><V><A><Y><P><M><V><A><A><Y><S><A><S><K><F><A><L><D><G><F><F><S><S><I><R><K><E><Y><S><V><S><R><V><N><V><S><I><T><L><C><V><L><G><L><I><D><T><E><T><A><M><K><A><V><S><G><I><V><H><M><Q><A><A><P><K><E><E><C><A><L><E><I><I><K><G><G><A><L><R><Q><E><E><V><Y><Y><D><S><S><L><W><T><T><L><L><I><R><N><P><C><R><K><I><L><E><F><L><Y><S><T><S><Y><N><M><D><R><F><I><N><K> | Controls the reversible conversion of biologically active glucocorticoids such as cortisone to cortisol, and 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) . Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes . Plays a role in the secretion of aqueous humor in the eye, maintaining a normotensive, intraocular environment . Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids . It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates . Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others . Catalyzes the stereo-specific conversion | P28845 |
Q02535 | ID3_HUMAN | Inhibitor of differentiation 3 | Homo | <M><K><A><L><S><P><V><R><G><C><Y><E><A><V><C><C><L><S><E><R><S><L><A><I><A><R><G><R><G><K><G><P><A><A><E><E><P><L><S><L><L><D><D><M><N><H><C><Y><S><R><L><R><E><L><V><P><G><V><P><R><G><T><Q><L><S><Q><V><E><I><L><Q><R><V><I><D><Y><I><L><D><L><Q><V><V><L><A><E><P><A><P><G><P><P><D><G><P><H><L><P><I><Q><T><A><E><L><T><P><E><L><V><I><S><N><D><K><R><S><F><C><H> | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.<BOP> | Q02535 |
Q9BWL3 | CA043_HUMAN | S863-3 | Homo | <M><A><S><G><S><N><W><L><S><G><V><N><V><V><L><V><M><A><Y><G><S><L><V><F><V><L><L><F><I><F><V><K><R><Q><I><M><R><F><A><M><K><S><R><R><G><P><H><V><P><V><G><H><N><A><P><K><D><L><K><E><E><I><D><I><R><L><S><R><V><Q><D><I><K><Y><E><P><Q><L><L><A><D><D><D><A><R><L><L><Q><L><E><T><Q><G><N><Q><S><C><Y><N><Y><L><Y><R><M><K><A><L><D><A><I><R><T><S><E><I><P><F><H><S><E><G><R><H><P><R><S><L><M><G><K><N><F><R><S><Y><L><L><D><L><R><N><T><S><T><P><F><K><G><V><R><K><A><L><I><D><T><L><L><D><G><Y><E><T><A><R><Y><G><T><G><V><F><G><Q><N><E><Y><L><R><Y><Q><E><A><L><S><E><L><A><T><A><V><K><A><R><I><G><S><S><Q><R><H><H><Q><S><A><A><K><D><L><T><Q><S><P><E><V><S><P><T><T><I><Q><V><T><Y><L><P><S><S><Q><K><S><K><R><A><K><H><F><L><E><L><K><S><F><K><D><N><Y><N><T><L><E><S><T><L> | General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.<BOP> | Q9BWL3 |
Q9Y3E7 | CHMP3_HUMAN | Vacuolar protein sorting-associated protein 24 | Homo | <M><G><L><F><G><K><T><Q><E><K><P><P><K><E><L><V><N><E><W><S><L><K><I><R><K><E><M><R><V><V><D><R><Q><I><R><D><I><Q><R><E><E><E><K><V><K><R><S><V><K><D><A><A><K><K><G><Q><K><D><V><C><I><V><L><A><K><E><M><I><R><S><R><K><A><V><S><K><L><Y><A><S><K><A><H><M><N><S><V><L><M><G><M><K><N><Q><L><A><V><L><R><V><A><G><S><L><Q><K><S><T><E><V><M><K><A><M><Q><S><L><V><K><I><P><E><I><Q><A><T><M><R><E><L><S><K><E><M><M><K><A><G><I><I><E><E><M><L><E><D><T><F><E><S><M><D><D><Q><E><E><M><E><E><E><A><E><M><E><I><D><R><I><L><F><E><I><T><A><G><A><L><G><K><A><P><S><K><V><T><D><A><L><P><E><P><E><P><P><G><A><M><A><A><S><E><D><E><E><E><E><E><E><A><L><E><A><M><Q><S><R><L><A><T><L><R><S> | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and P | Q9Y3E7 |
Q8TDR4 | TCP1L_HUMAN | TCP10-like | Homo | <M><L><A><G><Q><L><E><A><R><D><P><K><E><G><T><H><P><E><D><P><C><P><G><A><G><A><V><M><E><K><T><A><V><A><A><E><V><L><T><E><D><C><N><T><G><E><M><P><P><L><Q><Q><Q><I><I><R><L><H><Q><E><L><G><R><Q><K><S><L><W><A><D><V><H><G><K><L><R><S><H><I><D><A><L><R><E><Q><N><M><E><L><R><E><K><L><R><A><L><Q><L><Q><R><W><K><A><R><K><K><S><A><A><S><P><H><A><G><Q><E><S><H><T><L><A><L><E><P><A><F><G><K><I><S><P><L><S><A><D><E><E><T><I><P><K><Y><A><G><H><K><N><Q><S><A><T><L><L><G><Q><R><S><S><S><N><N><S><A><P><P><K><P><M><S><L><K><I><E><R><I><S><S><W><K><T><P><P><Q><E><N><R><D><K><N><L><S><R><R><R><Q><D><R><R><A><T><P><T><G><R><P><T><P><C><A><E><R><R><G><G><V> | May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.<BOP> | Q8TDR4 |
Q96RF0 | SNX18_HUMAN | SH3 and PX domain-containing protein 3B | Homo | <M><A><L><R><A><R><A><L><Y><D><F><R><S><E><N><P><G><E><I><S><L><R><E><H><E><V><L><S><L><C><S><E><Q><D><I><E><G><W><L><E><G><V><N><S><R><G><D><R><G><L><F><P><A><S><Y><V><Q><V><I><R><A><P><E><P><G><P><A><G><D><G><G><P><G><A><P><A><R><Y><A><N><V><P><P><G><G><F><E><P><L><P><V><A><P><P><A><S><F><K><P><P><P><D><A><F><Q><A><L><L><Q><P><Q><Q><A><P><P><P><S><T><F><Q><P><P><G><A><G><F><P><Y><G><G><G><A><L><Q><P><S><P><Q><Q><L><Y><G><G><Y><Q><A><S><Q><G><S><D><D><D><W><D><D><E><W><D><D><S><S><T><V><A><D><E><P><G><A><L><G><S><G><A><Y><P><D><L><D><G><S><S><S><A><G><V><G><A><A><G><R><Y><R><L><S><T><R><S><D><L><S><L><G><S><R><G><G><S><V><P><P><Q><H><H><P><S><G><P><K><S><S><A><T><V><S><R><N><L><N><R><F><S><T><F><V><K><S><G><G><E><A><F><V><L><G><E><A><S><G><F><V><K><D><G><D><K><L><C><V><V><L><G><P><Y><G><P><E><W><Q><E><N><P><Y><P><F><Q><C><T><I><D><D><P><T><K><Q><T><K><F><K><G><M><K><S><Y><I><S><Y><K><L><V><P><T><H><T><Q><V><P><V><H><R><R><Y><K><H><F><D><W><L><Y><A><R><L><A><E><K><F><P><V><I><S><V><P><H><L><P><E><K><Q><A><T><G><R><F><E><E><D><F><I><S><K><R><R><K><G><L><I><W><W><M><N><H><M><A><S><H><P><V><L><A><Q><C><D><V><F><Q><H><F><L><T><C><P><S><S><T><D><E><K><A><W><K><Q><G><K><R><K><A><E><K><D><E><M><V><G><A><N><F><F><L><T><L><S><T><P><P><A><A><A><L><D><L><Q><E><V><E><S><K><I><D><G><F><K><C><F><T><K><K><M><D><D><S><A><L><Q><L><N><H><T><A><N><E><F><A><R><K><Q><V><T><G><F><K><K><E><Y><Q><K><V><G><Q><S><F><R><G><L><S><Q><A><F><E><L><D><Q><Q><A><F><S><V><G><L><N><Q><A><I><A><F><T><G><D><A><Y><D><A><I><G><E><L><F><A><E><Q><P><R><Q><D><L><D><P><V><M><D><L><L><A><L><Y><Q><G><H><L><A><N><F><P><D><I><I><H><V><Q><K><G><K><A><W><P><L><E><Q><V><I><W><S><V><L><C><R><L><K><G><A><T><L><T><A><V><P><L><W><V><S><E><S><Y><S><T><G><E><E><A><S><R><D><V><D><A><W><V><F><S><L><E><C><K><L><D><C><S><T><G><S><F><L><L><E><Y><L><A><L><G><N><E><Y><S><F><S><K><V><Q><R><V><P><L><M><T><V><L><S><F> | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis . Required for efficient progress through mitosis and cytokinesis . Required for normal formation of the cleavage furrow at the end of mitosis . Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis . Plays a role in macropinocytosis . Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation . Stimulates the GTPase activity of DNM2 . Promotes DNM2 location at the plasma membrane . Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A .<BOP> | Q96RF0 |
Q8WTV1 | THAP3_HUMAN | THAP domain-containing protein 3 | Homo | <M><P><K><S><C><A><A><R><Q><C><C><N><R><Y><S><S><R><R><K><Q><L><T><F><H><R><F><P><F><S><R><P><E><L><L><K><E><W><V><L><N><I><G><R><G><N><F><K><P><K><Q><H><T><V><I><C><S><E><H><F><R><P><E><C><F><S><A><F><G><N><R><K><N><L><K><H><N><A><V><P><T><V><F><A><F><Q><D><P><T><Q><Q><V><R><E><N><T><D><P><A><S><E><R><G><N><A><S><S><S><Q><K><E><K><V><L><P><E><A><G><A><G><E><D><S><P><G><R><N><M><D><T><A><L><E><E><L><Q><L><P><P><N><A><E><G><H><V><K><Q><V><S><P><R><R><P><Q><A><T><E><A><V><G><R><P><T><G><P><A><G><L><R><R><T><P><N><K><Q><P><S><D><H><S><Y><A><L><L><D><L><D><S><L><K><K><K><L><F><L><T><L><K><E><N><E><K><L><R><K><R><L><Q><A><Q><R><L><V><M><R><R><M><S><S><R><L><R><A><C><K><G><H><Q><G><L><Q><A><R><L><G><P><E><Q><Q><S> | Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.<BOP> | Q8WTV1 |
Q9BUK6 | MSTO1_HUMAN | Protein misato homolog 1 | Homo | <M><A><G><G><A><R><E><V><L><T><L><Q><L><G><H><F><A><G><F><V><G><A><H><W><W><N><Q><Q><D><A><A><L><G><R><A><T><D><S><K><E><P><P><G><E><L><C><P><D><V><L><Y><R><T><G><R><T><L><H><G><Q><E><T><Y><T><P><R><L><I><L><M><D><L><K><G><S><L><S><S><L><K><E><E><G><G><L><Y><R><D><K><Q><L><D><A><A><I><A><W><Q><G><K><L><T><T><H><K><E><E><L><Y><P><K><N><P><Y><L><Q><D><F><L><S><A><E><G><V><L><S><S><D><G><V><W><R><V><K><S><I><P><N><G><K><G><S><S><P><L><P><T><A><T><T><P><K><P><L><I><P><T><E><A><S><I><R><V><W><S><D><F><L><R><V><H><L><H><P><R><S><I><C><M><I><Q><K><Y><N><H><D><G><E><A><G><R><L><E><A><F><G><Q><G><E><S><V><L><K><E><P><K><Y><Q><E><E><L><E><D><R><L><H><F><Y><V><E><E><C><D><Y><L><Q><G><F><Q><I><L><C><D><L><H><D><G><F><S><G><V><G><A><K><A><A><E><L><L><Q><D><E><Y><S><G><R><G><I><I><T><W><G><L><L><P><G><P><Y><H><R><G><E><A><Q><R><N><I><Y><R><L><L><N><T><A><F><G><L><V><H><L><T><A><H><S><S><L><V><C><P><L><S><L><G><G><S><L><G><L><R><P><E><P><P><V><S><F><P><Y><L><H><Y><D><A><T><L><P><F><H><C><S><A><I><L><A><T><A><L><D><T><V><T><V><P><Y><R><L><C><S><S><P><V><S><M><V><H><L><A><D><M><L><S><F><C><G><K><K><V><V><T><A><G><A><I><I><P><F><P><L><A><P><G><Q><S><L><P><D><S><L><M><Q><F><G><G><A><T><P><W><T><P><L><S><A><C><G><E><P><S><G><T><R><C><F><A><Q><S><V><V><L><R><G><I><D><R><A><C><H><T><S><Q><L><T><P><G><T><P><P><P><S><A><L><H><A><C><T><T><G><E><E><I><L><A><Q><Y><L><Q><Q><Q><Q><P><G><V><M><S><S><S><H><L><L><L><T><P><C><R><V><A><P><P><Y><P><H><L><F><S><S><C><S><P><P><G><M><V><L><D><G><S><P><K><G><A><A><V><E><S><I><P><V><F><G><A><L><C><S><S><S><S><L><H><Q><T><L><E><A><L><A><R><D><L><T><K><L><D><L><R><R><W><A><S><F><M><D><A><G><V><E><H><D><D><V><A><E><L><L><Q><E><L><Q><S><L><A><Q><C><Y><Q><G><G><D><S><L><V><D> | Involved in the regulation of mitochondrial distribution and morphology . Required for mitochondrial fusion and mitochondrial network formation .<BOP> | Q9BUK6 |
Q8IYM9 | TRI22_HUMAN | Tripartite motif-containing protein 22 | Homo | <M><D><F><S><V><K><V><D><I><E><K><E><V><T><C><P><I><C><L><E><L><L><T><E><P><L><S><L><D><C><G><H><S><F><C><Q><A><C><I><T><A><K><I><K><E><S><V><I><I><S><R><G><E><S><S><C><P><V><C><Q><T><R><F><Q><P><G><N><L><R><P><N><R><H><L><A><N><I><V><E><R><V><K><E><V><K><M><S><P><Q><E><G><Q><K><R><D><V><C><E><H><H><G><K><K><L><Q><I><F><C><K><E><D><G><K><V><I><C><W><V><C><E><L><S><Q><E><H><Q><G><H><Q><T><F><R><I><N><E><V><V><K><E><C><Q><E><K><L><Q><V><A><L><Q><R><L><I><K><E><D><Q><E><A><E><K><L><E><D><D><I><R><Q><E><R><T><A><W><K><N><Y><I><Q><I><E><R><Q><K><I><L><K><G><F><N><E><M><R><V><I><L><D><N><E><E><Q><R><E><L><Q><K><L><E><E><G><E><V><N><V><L><D><N><L><A><A><A><T><D><Q><L><V><Q><Q><R><Q><D><A><S><T><L><I><S><D><L><Q><R><R><L><R><G><S><S><V><E><M><L><Q><D><V><I><D><V><M><K><R><S><E><S><W><T><L><K><K><P><K><S><V><S><K><K><L><K><S><V><F><R><V><P><D><L><S><G><M><L><Q><V><L><K><E><L><T><D><V><Q><Y><Y><W><V><D><V><M><L><N><P><G><S><A><T><S><N><V><A><I><S><V><D><Q><R><Q><V><K><T><V><R><T><C><T><F><K><N><S><N><P><C><D><F><S><A><F><G><V><F><G><C><Q><Y><F><S><S><G><K><Y><Y><W><E><V><D><V><S><G><K><I><A><W><I><L><G><V><H><S><K><I><S><S><L><N><K><R><K><S><S><G><F><A><F><D><P><S><V><N><Y><S><K><V><Y><S><R><Y><R><P><Q><Y><G><Y><W><V><I><G><L><Q><N><T><C><E><Y><N><A><F><E><D><S><S><S><S><D><P><K><V><L><T><L><F><M><A><V><P><P><C><R><I><G><V><F><L><D><Y><E><A><G><I><V><S><F><F><N><V><T><N><H><G><A><L><I><Y><K><F><S><G><C><R><F><S><R><P><A><Y><P><Y><F><N><P><W><N><C><L><V><P><M><T><V><C><P><P><S><S> | Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.<BOP> | Q8IYM9 |
Q3MIR4 | CC50B_HUMAN | Transmembrane protein 30B | Homo | <M><T><W><S><A><T><A><R><G><A><H><Q><P><D><N><T><A><F><T><Q><Q><R><L><P><A><W><Q><P><L><L><S><A><S><I><A><L><P><L><F><F><C><A><G><L><A><F><I><G><L><G><L><G><L><Y><Y><S><S><N><G><I><K><E><L><E><Y><D><Y><T><G><D><P><G><T><G><N><C><S><V><C><A><A><A><G><Q><G><R><A><L><P><P><P><C><S><C><A><W><Y><F><S><L><P><E><L><F><Q><G><P><V><Y><L><Y><Y><E><L><T><N><F><Y><Q><N><N><R><R><Y><G><V><S><R><D><D><A><Q><L><S><G><L><P><S><A><L><R><H><P><V><N><E><C><A><P><Y><Q><R><S><A><A><G><L><P><I><A><P><C><G><A><I><A><N><S><L><F><N><D><S><F><S><L><W><H><Q><R><Q><P><G><G><P><Y><V><E><V><P><L><D><R><S><G><I><A><W><W><T><D><Y><H><V><K><F><R><N><P><P><L><V><N><G><S><L><A><L><A><F><Q><G><T><A><P><P><P><N><W><R><R><P><V><Y><E><L><S><P><D><P><N><N><T><G><F><I><N><Q><D><F><V><V><W><M><R><T><A><A><L><P><T><F><R><K><L><Y><A><R><I><R><Q><G><N><Y><S><A><G><L><P><R><G><A><Y><R><V><N><I><T><Y><N><Y><P><V><R><A><F><G><G><H><K><L><L><I><F><S><S><I><S><W><M><G><G><K><N><P><F><L><G><I><A><Y><L><V><V><G><S><L><C><I><L><T><G><F><V><M><L><V><V><Y><I><R><Y><Q><D><Q><D><D><D><D><E><E> | Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.<BOP> | Q3MIR4 |
Q9H1K4 | GHC2_HUMAN | Solute carrier family 25 member 18 | Homo | <M><T><H><Q><D><L><S><I><T><A><K><L><I><N><G><G><V><A><G><L><V><G><V><T><C><V><F><P><I><D><L><A><K><T><R><L><Q><N><Q><H><G><K><A><M><Y><K><G><M><I><D><C><L><M><K><T><A><R><A><E><G><F><F><G><M><Y><R><G><A><A><V><N><L><T><L><V><T><P><E><K><A><I><K><L><A><A><N><D><F><F><R><R><L><L><M><E><D><G><M><Q><R><N><L><K><M><E><M><L><A><G><C><G><A><G><M><C><Q><V><V><V><T><C><P><M><E><M><L><K><I><Q><L><Q><D><A><G><R><L><A><V><H><H><Q><G><S><A><S><A><P><S><T><S><R><S><Y><T><T><G><S><A><S><T><H><R><R><P><S><A><T><L><I><A><W><E><L><L><R><T><Q><G><L><A><G><L><Y><R><G><L><G><A><T><L><L><R><D><I><P><F><S><I><I><Y><F><P><L><F><A><N><L><N><N><L><G><F><N><E><L><A><G><K><A><S><F><A><H><S><F><V><S><G><C><V><A><G><S><I><A><A><V><A><V><T><P><L><D><V><L><K><T><R><I><Q><T><L><K><K><G><L><G><E><D><M><Y><S><G><I><T><D><C><A><R><K><L><W><I><Q><E><G><P><S><A><F><M><K><G><A><G><C><R><A><L><V><I><A><P><L><F><G><I><A><Q><G><V><Y><F><I><G><I><G><E><R><I><L><K><C><F><D> | Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system).<BOP> | Q9H1K4 |
Q9UGF5 | O14J1_HUMAN | Olfactory receptor OR6-25 | Homo | <M><V><N><L><T><S><M><S><G><F><L><L><M><G><F><S><D><E><R><K><L><Q><I><L><H><A><L><V><F><L><V><T><Y><L><L><A><L><T><G><N><L><L><I><I><T><I><I><T><V><D><R><R><L><H><S><P><M><Y><Y><F><L><K><H><L><S><L><L><D><L><C><F><I><S><V><T><V><P><Q><S><I><A><N><S><L><M><G><N><G><Y><I><S><L><V><Q><C><I><L><Q><V><F><F><F><I><A><L><A><S><S><E><V><A><I><L><T><V><M><S><Y><D><R><Y><A><A><I><C><Q><P><L><H><Y><E><T><I><M><D><P><R><A><C><R><H><A><V><I><A><V><W><I><A><G><G><L><S><G><L><M><H><A><A><I><N><F><S><I><P><L><C><G><K><R><V><I><H><Q><F><F><C><D><V><P><Q><M><L><K><L><A><C><S><Y><E><F><I><N><E><I><A><L><A><A><F><T><T><S><A><A><F><I><C><L><I><S><I><V><L><S><Y><I><R><I><F><S><T><V><L><R><I><P><S><A><E><G><R><T><K><V><F><S><T><C><L><P><H><L><F><V><A><T><F><F><L><S><A><A><G><F><E><F><L><R><L><P><S><D><S><S><S><T><V><D><L><V><F><S><V><F><Y><T><V><I><P><P><T><L><N><P><V><I><Y><S><L><R><N><D><S><M><K><A><A><L><R><K><M><L><S><K><E><E><L><P><Q><R><K><M><C><L><K><A><M><F><K><L> | Odorant receptor.<BOP> | Q9UGF5 |
Q16589 | CCNG2_HUMAN | Cyclin-G2 | Homo | <M><K><D><L><G><A><E><H><L><A><G><H><E><G><V><Q><L><L><G><L><L><N><V><Y><L><E><Q><E><E><R><F><Q><P><R><E><K><G><L><S><L><I><E><A><T><P><E><N><D><N><T><L><C><P><G><L><R><N><A><K><V><E><D><L><R><S><L><A><N><F><F><G><S><C><T><E><T><F><V><L><A><V><N><I><L><D><R><F><L><A><L><M><K><V><K><P><K><H><L><S><C><I><G><V><C><S><F><L><L><A><A><R><I><V><E><E><D><C><N><I><P><S><T><H><D><V><I><R><I><S><Q><C><K><C><T><A><S><D><I><K><R><M><E><K><I><I><S><E><K><L><H><Y><E><L><E><A><T><T><A><L><N><F><L><H><L><Y><H><T><I><I><L><C><H><T><S><E><R><K><E><I><L><S><L><D><K><L><E><A><Q><L><K><A><C><N><C><R><L><I><F><S><K><A><K><P><S><V><L><A><L><C><L><L><N><L><E><V><E><T><L><K><S><V><E><L><L><E><I><L><L><L><V><K><K><H><S><K><I><N><D><T><E><F><F><Y><W><R><E><L><V><S><K><C><L><A><E><Y><S><S><P><E><C><C><K><P><D><L><K><K><L><V><W><I><V><S><R><R><T><A><Q><N><L><H><N><S><Y><Y><S><V><P><E><L><P><T><I><P><E><G><G><C><F><D><E><S><E><S><E><D><S><C><E><D><M><S><C><G><E><E><S><L><S><S><S><P><P><S><D><Q><E><C><T><F><F><F><N><F><K><V><A><Q><T><L><C><F><P><S> | May play a role in growth regulation and in negative regulation of cell cycle progression.<BOP> | Q16589 |
O43603 | GALR2_HUMAN | Galanin receptor type 2 | Homo | <M><N><V><S><G><C><P><G><A><G><N><A><S><Q><A><G><G><G><G><G><W><H><P><E><A><V><I><V><P><L><L><F><A><L><I><F><L><V><G><T><V><G><N><T><L><V><L><A><V><L><L><R><G><G><Q><A><V><S><T><T><N><L><F><I><L><N><L><G><V><A><D><L><C><F><I><L><C><C><V><P><F><Q><A><T><I><Y><T><L><D><G><W><V><F><G><S><L><L><C><K><A><V><H><F><L><I><F><L><T><M><H><A><S><S><F><T><L><A><A><V><S><L><D><R><Y><L><A><I><R><Y><P><L><H><S><R><E><L><R><T><P><R><N><A><L><A><A><I><G><L><I><W><G><L><S><L><L><F><S><G><P><Y><L><S><Y><Y><R><Q><S><Q><L><A><N><L><T><V><C><H><P><A><W><S><A><P><R><R><R><A><M><D><I><C><T><F><V><F><S><Y><L><L><P><V><L><V><L><G><L><T><Y><A><R><T><L><R><Y><L><W><R><A><V><D><P><V><A><A><G><S><G><A><R><R><A><K><R><K><V><T><R><M><I><L><I><V><A><A><L><F><C><L><C><W><M><P><H><H><A><L><I><L><C><V><W><F><G><Q><F><P><L><T><R><A><T><Y><A><L><R><I><L><S><H><L><V><S><Y><A><N><S><C><V><N><P><I><V><Y><A><L><V><S><K><H><F><R><K><G><F><R><T><I><C><A><G><L><L><G><R><A><P><G><R><A><S><G><R><V><C><A><A><A><R><G><T><H><S><G><S><V><L><E><R><E><S><S><D><L><L><H><M><S><E><A><A><G><A><L><R><P><C><P><G><A><S><Q><P><C><I><L><E><P><C><P><G><P><S><W><Q><G><P><K><A><G><D><S><I><L><T><V><D><V><A> | Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 . The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).<BOP> | O43603 |
Q6IF82 | O4A47_HUMAN | Olfactory receptor OR11-113 | Homo | <M><E><P><R><K><N><V><T><D><F><V><L><L><G><F><T><Q><N><P><K><E><Q><K><V><L><F><V><M><F><L><L><F><Y><I><L><T><M><V><G><N><L><L><I><V><V><T><V><T><V><S><E><T><L><G><S><P><M><Y><F><F><L><A><G><L><S><F><I><D><I><I><Y><S><S><S><I><S><P><R><L><I><S><G><L><F><F><G><N><N><S><I><S><F><Q><S><C><M><A><Q><L><F><I><E><H><I><F><G><G><S><E><V><F><L><L><L><V><M><A><Y><D><C><Y><V><A><I><C><K><P><L><H><Y><L><V><I><M><R><Q><W><V><C><V><V><L><L><V><V><S><W><V><G><G><F><L><H><S><V><F><Q><L><S><I><I><Y><G><L><P><F><C><G><P><N><V><I><D><H><F><F><C><D><M><Y><P><L><L><K><L><V><C><T><D><T><H><A><I><G><L><L><V><V><A><N><G><G><L><A><C><T><I><V><F><L><L><L><L><I><S><Y><G><V><I><L><H><S><L><K><N><L><S><Q><K><G><R><Q><K><A><L><S><T><C><S><S><H><M><T><V><V><V><F><F><F><V><P><C><I><F><M><Y><A><R><P><A><R><T><F><P><I><D><K><S><V><S><V><F><Y><T><V><I><T><P><M><L><N><P><L><I><Y><T><L><R><N><S><E><M><T><S><A><M><K><K><L><W><R><R><D><L><I><S><S><S><T> | Odorant receptor.<BOP> | Q6IF82 |
Q6IF63 | O52W1_HUMAN | Olfactory receptor OR11-71 | Homo | <M><A><E><T><L><Q><L><N><S><T><F><L><H><P><N><F><F><I><L><T><G><F><P><G><L><G><S><A><Q><T><W><L><T><L><V><F><G><P><I><Y><L><L><A><L><L><G><N><G><A><L><P><A><V><V><W><I><D><S><T><L><H><Q><P><M><F><L><L><L><A><I><L><A><A><T><D><L><G><L><A><T><S><I><A><P><G><L><L><A><V><L><W><L><G><P><R><S><V><P><Y><A><V><C><L><V><Q><M><F><F><V><H><A><L><T><A><M><E><S><G><V><L><L><A><M><A><C><D><R><A><A><A><I><G><R><P><L><H><Y><P><V><L><V><T><K><A><C><V><G><Y><A><A><L><A><L><A><L><K><A><V><A><I><V><V><P><F><P><L><L><V><A><K><F><E><H><F><Q><A><K><T><I><G><H><T><Y><C><A><H><M><A><V><V><E><L><V><V><G><N><T><Q><A><T><N><L><Y><G><L><A><L><S><L><A><I><S><G><M><D><I><L><G><I><T><G><S><Y><G><L><I><A><H><A><V><L><Q><L><P><T><R><E><A><H><A><K><A><F><G><T><C><S><S><H><I><C><V><I><L><A><F><Y><I><P><G><L><F><S><Y><L><T><H><R><F><G><H><H><T><V><P><K><P><V><H><I><L><L><S><N><I><Y><L><L><L><P><P><A><L><N><P><L><I><Y><G><A><R><T><K><Q><I><R><D><R><L><L><E><T><F><T><F><R><K><S><P><L> | Odorant receptor.<BOP> | Q6IF63 |
Q8N0U8 | VKORL_HUMAN | Vitamin K epoxide reductase complex subunit 1-like protein 1 | Homo | <M><A><A><P><V><L><L><R><V><S><V><P><R><W><E><R><V><A><R><Y><A><V><C><A><A><G><I><L><L><S><I><Y><A><Y><H><V><E><R><E><K><E><R><D><P><E><H><R><A><L><C><D><L><G><P><W><V><K><C><S><A><A><L><A><S><R><W><G><R><G><F><G><L><L><G><S><I><F><G><K><D><G><V><L><N><Q><P><N><S><V><F><G><L><I><F><Y><I><L><Q><L><L><L><G><M><T><A><S><A><V><A><A><L><I><L><M><T><S><S><I><M><S><V><V><G><S><L><Y><L><A><Y><I><L><Y><F><V><L><K><E><F><C><I><I><C><I><V><T><Y><V><L><N><F><L><L><L><I><I><N><Y><K><R><L><V><Y><L><N><E><A><W><K><R><Q><L><Q><P><K><Q><D> | Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.<BOP> | Q8N0U8 |
Q6IQ16 | SPOPL_HUMAN | Roadkill homolog 2 | Homo | <M><S><R><E><P><T><P><P><L><P><G><D><M><S><T><G><P><I><A><E><S><W><C><Y><T><Q><V><K><V><V><K><F><S><Y><M><W><T><I><N><N><F><S><F><C><R><E><E><M><G><E><V><L><K><S><S><T><F><S><S><G><P><S><D><K><M><K><W><C><L><R><V><N><P><K><G><L><D><D><E><S><K><D><Y><L><S><L><Y><L><L><L><V><S><C><P><K><S><E><V><R><A><K><F><K><F><S><L><L><N><A><K><R><E><E><T><K><A><M><E><S><Q><R><A><Y><R><F><V><Q><G><K><D><W><G><F><K><K><F><I><R><R><D><F><L><L><D><E><A><N><G><L><L><P><D><D><K><L><T><L><F><C><E><V><S><V><V><Q><D><S><V><N><I><S><G><H><T><N><T><N><T><L><K><V><P><E><C><R><L><A><E><D><L><G><N><L><W><E><N><T><R><F><T><D><C><S><F><F><V><R><G><Q><E><F><K><A><H><K><S><V><L><A><A><R><S><P><V><F><N><A><M><F><E><H><E><M><E><E><S><K><K><N><R><V><E><I><N><D><L><D><P><E><V><F><K><E><M><M><R><F><I><Y><T><G><R><A><P><N><L><D><K><M><A><D><N><L><L><A><A><A><D><K><Y><A><L><E><R><L><K><V><M><C><E><E><A><L><C><S><N><L><S><V><E><N><V><A><D><T><L><V><L><A><D><L><H><S><A><E><Q><L><K><A><Q><A><I><D><F><I><N><R><C><S><V><L><R><Q><L><G><C><K><D><G><K><N><W><N><S><N><Q><A><T><D><I><M><E><T><S><G><W><K><S><M><I><Q><S><H><P><H><L><V><A><E><A><F><R><A><L><A><S><A><Q><C><P><Q><F><G><I><P><R><K><R><L><K><Q><S> | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.<BOP> | Q6IQ16 |
Q9H6A0 | DEN2D_HUMAN | DENN domain-containing protein 2D | Homo | <M><E><G><Q><V><V><G><R><V><F><R><L><F><Q><R><R><L><L><Q><L><R><A><G><P><P><Q><D><N><S><G><E><A><L><K><E><P><E><R><A><Q><E><H><S><L><P><N><F><A><G><G><Q><H><F><F><E><Y><L><L><V><V><S><L><K><K><K><R><S><E><D><D><Y><E><P><I><I><T><Y><Q><F><P><K><R><E><N><L><L><R><G><Q><Q><E><E><E><E><R><L><L><K><A><I><P><L><F><C><F><P><D><G><N><E><W><A><S><L><T><E><Y><P><R><E><T><F><S><F><V><L><T><N><V><D><G><S><R><K><I><G><Y><C><R><R><L><L><P><A><G><P><G><P><R><L><P><K><V><Y><C><I><I><S><C><I><G><C><F><G><L><F><S><K><I><L><D><E><V><E><K><R><H><Q><I><S><M><A><V><I><Y><P><F><M><Q><G><L><R><E><A><A><F><P><A><P><G><K><T><V><T><L><K><S><F><I><P><D><S><G><T><E><F><I><S><L><T><R><P><L><D><S><H><L><E><H><V><D><F><S><S><L><L><H><C><L><S><F><E><Q><I><L><Q><I><F><A><S><A><V><L><E><R><K><I><I><F><L><A><E><G><L><S><T><L><S><Q><C><I><H><A><A><A><A><L><L><Y><P><F><S><W><A><H><T><Y><I><P><V><V><P><E><S><L><L><A><T><V><C><C><P><T><P><F><M><V><G><V><Q><M><R><F><Q><Q><E><V><M><D><S><P><M><E><E><V><L><L><V><N><L><C><E><G><T><F><L><M><S><V><G><D><E><K><D><I><L><P><P><K><L><Q><D><D><I><L><D><S><L><G><Q><G><I><N><E><L><K><T><A><E><Q><I><N><E><H><V><S><G><P><F><V><Q><F><F><V><K><I><V><G><H><Y><A><S><Y><I><K><R><E><A><N><G><Q><G><H><F><Q><E><R><S><F><C><K><A><L><T><S><K><T><N><R><R><F><V><K><K><F><V><K><T><Q><L><F><S><L><F><I><Q><E><A><E><K><S><K><N><P><P><A><G><Y><F><Q><Q><K><I><L><E><Y><E><E><Q><K><K><Q><K><K><P><R><E><K><T><V><K> | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.<BOP> | Q9H6A0 |
Q96BI3 | APH1A_HUMAN | Presenilin-stabilization factor | Homo | <M><G><A><A><V><F><F><G><C><T><F><V><A><F><G><P><A><F><A><L><F><L><I><T><V><A><G><D><P><L><R><V><I><I><L><V><A><G><A><F><F><W><L><V><S><L><L><L><A><S><V><V><W><F><I><L><V><H><V><T><D><R><S><D><A><R><L><Q><Y><G><L><L><I><F><G><A><A><V><S><V><L><L><Q><E><V><F><R><F><A><Y><Y><K><L><L><K><K><A><D><E><G><L><A><S><L><S><E><D><G><R><S><P><I><S><I><R><Q><M><A><Y><V><S><G><L><S><F><G><I><I><S><G><V><F><S><V><I><N><I><L><A><D><A><L><G><P><G><V><V><G><I><H><G><D><S><P><Y><Y><F><L><T><S><A><F><L><T><A><A><I><I><L><L><H><T><F><W><G><V><V><F><F><D><A><C><E><R><R><R><Y><W><A><L><G><L><V><V><G><S><H><L><L><T><S><G><L><T><F><L><N><P><W><Y><E><A><S><L><L><P><I><Y><A><V><T><V><S><M><G><L><W><A><F><I><T><A><G><G><S><L><R><S><I><Q><R><S><L><L><C><R><R><Q><E><D><S><R><V><M><V><Y><S><A><L><R><I><P><P><E><D> | Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) . Required for normal gamma-secretase assembly . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).<BOP> | Q96BI3 |
Q9NY28 | GALT8_HUMAN | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 8 | Homo | <M><M><F><W><R><K><L><P><K><A><L><F><I><G><L><T><L><A><I><A><V><N><L><L><L><V><F><S><S><K><G><T><L><Q><N><L><F><T><G><G><L><H><R><E><L><P><L><H><L><N><K><R><Y><G><A><V><I><K><R><L><S><H><L><E><V><E><L><Q><D><L><K><E><S><M><K><L><A><L><R><Q><Q><E><N><V><N><S><T><L><K><R><A><K><D><E><V><R><P><L><L><K><A><M><E><T><K><V><N><E><T><K><K><H><K><T><Q><M><K><L><F><P><H><S><Q><L><F><R><Q><W><G><E><D><L><S><E><A><Q><Q><K><A><A><Q><D><L><F><R><K><F><G><Y><N><A><Y><L><S><N><Q><L><P><L><N><R><T><I><P><D><T><R><D><Y><R><C><L><R><K><T><Y><P><S><Q><L><P><S><L><S><V><I><L><I><F><V><N><E><A><L><S><I><I><Q><R><A><I><T><S><I><I><N><R><T><P><S><R><L><L><K><E><I><I><L><V><D><D><F><S><S><N><G><E><L><K><V><H><L><D><E><K><I><K><L><Y><N><Q><K><Y><P><G><L><L><K><I><I><R><H><P><E><R><K><G><L><A><Q><A><R><N><T><G><W><E><A><A><T><A><D><V><V><A><I><L><D><A><H><I><E><V><N><V><G><W><A><E><P><I><L><A><R><I><Q><E><D><R><T><V><I><V><S><P><V><F><D><N><I><R><F><D><T><F><K><L><D><K><Y><E><L><A><V><D><G><F><N><W><E><L><W><C><R><Y><D><A><L><P><Q><A><W><I><D><L><H><D><V><T><A><P><V><K><S><P><S><I><M><G><I><L><A><A><N><R><H><F><L><G><E><I><G><S><L><D><G><G><M><L><I><Y><G><G><E><N><V><E><L><S><L><R><V><W><Q><C><G><G><K><V><E><I><L><P><C><S><R><I><A><H><L><E><R><H><H><K><P><Y><A><L><D><L><T><A><A><L><K><R><N><A><L><R><V><A><E><I><W><M><D><E><H><K><H><M><V><Y><L><A><W><N><I><P><L><Q><N><S><G><I><D><F><G><D><V><S><S><R><M><A><L><R><E><K><L><K><C><K><T><F><D><W><Y><L><K><N><V><Y><P><L><L><K><P><L><H><T><I><V><G><Y><G><R><M><K><N><L><L><D><E><N><V><C><L><D><Q><G><P><V><P><G><N><T><P><I><M><Y><Y><C><H><E><F><S><S><Q><N><V><Y><Y><H><L><T><G><E><L><Y><V><G><Q><L><I><A><E><A><S><A><S><D><R><C><L><T><D><P><G><K><A><E><K><P><T><L><E><P><C><S><K><A><A><K><N><R><L><H><I><Y><W><D><F><K><P><G><G><A><V><I><N><R><D><T><K><R><C><L><E><M><K><K><D><L><L><G><S><H><V><L><V><L><Q><T><C><S><T><Q><V><W><E><I><Q><H><T><V><R><D><W><G><Q><T><N><S><Q> | Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.<BOP> | Q9NY28 |
P50151 | GBG10_HUMAN | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | Homo | <M><S><S><G><A><S><A><S><A><L><Q><R><L><V><E><Q><L><K><L><E><A><G><V><E><R><I><K><V><S><Q><A><A><A><E><L><Q><Q><Y><C><M><Q><N><A><C><K><D><A><L><L><V><G><V><P><A><G><S><N><P><F><R><E><P><R><S><C><A><L><L> | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.<BOP> | P50151 |
Q9GZQ8 | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta | Homo | <M><P><S><E><K><T><F><K><Q><R><R><T><F><E><Q><R><V><E><D><V><R><L><I><R><E><Q><H><P><T><K><I><P><V><I><I><E><R><Y><K><G><E><K><Q><L><P><V><L><D><K><T><K><F><L><V><P><D><H><V><N><M><S><E><L><I><K><I><I><R><R><R><L><Q><L><N><A><N><Q><A><F><F><L><L><V><N><G><H><S><M><V><S><V><S><T><P><I><S><E><V><Y><E><S><E><K><D><E><D><G><F><L><Y><M><V><Y><A><S><Q><E><T><F><G><M><K><L><S><V> | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) . Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production . In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria . While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation . Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway . Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover . Upon nutrient stress, directly recruits cofactor JMY to the phagophore membrane surfaces and promotes JMY's actin nucleation activity and autophagosome biogenesis during aut | Q9GZQ8 |
O60487 | MPZL2_HUMAN | Epithelial V-like antigen 1 | Homo | <M><Y><G><K><S><S><T><R><A><V><L><L><L><L><G><I><Q><L><T><A><L><W><P><I><A><A><V><E><I><Y><T><S><R><V><L><E><A><V><N><G><T><D><A><R><L><K><C><T><F><S><S><F><A><P><V><G><D><A><L><T><V><T><W><N><F><R><P><L><D><G><G><P><E><Q><F><V><F><Y><Y><H><I><D><P><F><Q><P><M><S><G><R><F><K><D><R><V><S><W><D><G><N><P><E><R><Y><D><A><S><I><L><L><W><K><L><Q><F><D><D><N><G><T><Y><T><C><Q><V><K><N><P><P><D><V><D><G><V><I><G><E><I><R><L><S><V><V><H><T><V><R><F><S><E><I><H><F><L><A><L><A><I><G><S><A><C><A><L><M><I><I><I><V><I><V><V><V><L><F><Q><H><Y><R><K><K><R><W><A><E><R><A><H><K><V><V><E><I><K><S><K><E><E><E><R><L><N><Q><E><K><K><V><S><V><Y><L><E><D><T><D> | Mediates homophilic cell-cell adhesion.<BOP> | O60487 |
Q9H4B6 | SAV1_HUMAN | 45 kDa WW domain protein | Homo | <M><L><S><R><K><K><T><K><N><E><V><S><K><P><A><E><V><Q><G><K><Y><V><K><K><E><T><S><P><L><L><R><N><L><M><P><S><F><I><R><H><G><P><T><I><P><R><R><T><D><I><C><L><P><D><S><S><P><N><A><F><S><T><S><G><D><V><V><S><R><N><Q><S><F><L><R><T><P><I><Q><R><T><P><H><E><I><M><R><R><E><S><N><R><L><S><A><P><S><Y><L><A><R><S><L><A><D><V><P><R><E><Y><G><S><S><Q><S><F><V><T><E><V><S><F><A><V><E><N><G><D><S><G><S><R><Y><Y><Y><S><D><N><F><F><D><G><Q><R><K><R><P><L><G><D><R><A><H><E><D><Y><R><Y><Y><E><Y><N><H><D><L><F><Q><R><M><P><Q><N><Q><G><R><H><A><S><G><I><G><R><V><A><A><T><S><L><G><N><L><T><N><H><G><S><E><D><L><P><L><P><P><G><W><S><V><D><W><T><M><R><G><R><K><Y><Y><I><D><H><N><T><N><T><T><H><W><S><H><P><L><E><R><E><G><L><P><P><G><W><E><R><V><E><S><S><E><F><G><T><Y><Y><V><D><H><T><N><K><K><A><Q><Y><R><H><P><C><A><P><S><V><P><R><Y><D><Q><P><P><P><V><T><Y><Q><P><Q><Q><T><E><R><N><Q><S><L><L><V><P><A><N><P><Y><H><T><A><E><I><P><D><W><L><Q><V><Y><A><R><A><P><V><K><Y><D><H><I><L><K><W><E><L><F><Q><L><A><D><L><D><T><Y><Q><G><M><L><K><L><L><F><M><K><E><L><E><Q><I><V><K><M><Y><E><A><Y><R><Q><A><L><L><T><E><L><E><N><R><K><Q><R><Q><Q><W><Y><A><Q><Q><H><G><K><N><F> | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. | Q9H4B6 |
O60664 | PLIN3_HUMAN | Placental protein 17 | Homo | <M><S><A><D><G><A><E><A><D><G><S><T><Q><V><T><V><E><E><P><V><Q><Q><P><S><V><V><D><R><V><A><S><M><P><L><I><S><S><T><C><D><M><V><S><A><A><Y><A><S><T><K><E><S><Y><P><H><I><K><T><V><C><D><A><A><E><K><G><V><R><T><L><T><A><A><A><V><S><G><A><Q><P><I><L><S><K><L><E><P><Q><I><A><S><A><S><E><Y><A><H><R><G><L><D><K><L><E><E><N><L><P><I><L><Q><Q><P><T><E><K><V><L><A><D><T><K><E><L><V><S><S><K><V><S><G><A><Q><E><M><V><S><S><A><K><D><T><V><A><T><Q><L><S><E><A><V><D><A><T><R><G><A><V><Q><S><G><V><D><K><T><K><S><V><V><T><G><G><V><Q><S><V><M><G><S><R><L><G><Q><M><V><L><S><G><V><D><T><V><L><G><K><S><E><E><W><A><D><N><H><L><P><L><T><D><A><E><L><A><R><I><A><T><S><L><D><G><F><D><V><A><S><V><Q><Q><Q><R><Q><E><Q><S><Y><F><V><R><L><G><S><L><S><E><R><L><R><Q><H><A><Y><E><H><S><L><G><K><L><R><A><T><K><Q><R><A><Q><E><A><L><L><Q><L><S><Q><V><L><S><L><M><E><T><V><K><Q><G><V><D><Q><K><L><V><E><G><Q><E><K><L><H><Q><M><W><L><S><W><N><Q><K><Q><L><Q><G><P><E><K><E><P><P><K><P><E><Q><V><E><S><R><A><L><T><M><F><R><D><I><A><Q><Q><L><Q><A><T><C><T><S><L><G><S><S><I><Q><G><L><P><T><N><V><K><D><Q><V><Q><Q><A><R><R><Q><V><E><D><L><Q><A><T><F><S><S><I><H><S><F><Q><D><L><S><S><S><I><L><A><Q><S><R><E><R><V><A><S><A><R><E><A><L><D><H><M><V><E><Y><V><A><Q><N><T><P><V><T><W><L><V><G><P><F><A><P><G><I><T><E><K><A><P><E><E><K><K> | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets . Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network .<BOP> | O60664 |
P09912 | IFI6_HUMAN | Interferon-induced protein 6-16 | Homo | <M><R><Q><K><A><V><S><L><F><L><C><Y><L><L><L><F><T><C><S><G><V><E><A><G><K><K><K><C><S><E><S><S><D><S><G><S><G><F><W><K><A><L><T><F><M><A><V><G><G><G><L><A><V><A><G><L><P><A><L><G><F><T><G><A><G><I><A><A><N><S><V><A><A><S><L><M><S><W><S><A><I><L><N><G><G><G><V><P><A><G><G><L><V><A><T><L><Q><S><L><G><A><G><G><S><S><V><V><I><G><N><I><G><A><L><M><G><Y><A><T><H><K><Y><L><D><S><E><E><D><E><E> | Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis . However, it has also been shown to have a pro-apoptotic activity . Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells .<BOP> | P09912 |
Q9HC58 | NCKX3_HUMAN | Solute carrier family 24 member 3 | Homo | <M><R><P><S><G><D><E><D><R><A><R><R><R><R><R><R><R><R><R><R><D><L><L><L><S><Q><L><C><F><L><A><S><V><A><L><L><L><W><S><L><S><S><L><R><E><Q><K><E><L><D><L><M><D><L><V><G><E><D><R><K><W><M><M><A><R><K><L><M><Q><V><N><D><T><L><T><S><E><D><A><G><L><R><N><S><K><N><C><T><E><P><A><L><H><E><F><P><N><D><I><F><T><N><E><D><R><R><Q><G><A><V><V><L><H><V><L><C><A><I><Y><M><F><Y><A><L><A><I><V><C><D><D><F><F><V><P><S><L><E><K><I><C><E><R><L><H><L><S><E><D><V><A><G><A><T><F><M><A><A><G><S><S><A><P><E><L><F><T><S><V><I><G><V><F><I><T><K><G><D><V><G><V><G><T><I><V><G><S><A><V><F><N><I><L><C><I><I><G><V><C><G><L><F><A><G><Q><V><V><A><L><S><S><W><C><L><L><R><D><S><I><Y><Y><T><L><S><V><I><A><L><I><V><F><I><Y><D><E><K><V><S><W><W><E><S><L><V><L><V><L><M><Y><L><I><Y><I><V><I><M><K><Y><N><A><C><I><H><Q><C><F><E><R><R><T><K><G><A><G><N><M><V><N><G><L><A><N><N><A><E><I><D><D><S><S><N><C><D><A><T><V><V><L><L><K><K><A><N><F><H><R><K><A><S><V><I><M><V><D><E><L><L><S><A><Y><P><H><Q><L><S><F><S><E><A><G><L><R><I><M><I><T><S><H><F><P><P><K><T><R><L><S><M><A><S><R><M><L><I><N><E><R><Q><R><L><I><N><S><R><A><Y><T><N><G><E><S><E><V><A><I><K><I><P><I><K><H><T><V><E><N><G><T><G><P><S><S><A><P><D><R><G><V><N><G><T><R><R><D><D><V><V><A><E><A><G><N><E><T><E><N><E><N><E><D><N><E><N><D><E><E><E><E><E><D><E><D><D><D><E><G><P><Y><T><P><F><D><T><P><S><G><K><L><E><T><V><K><W><A><F><T><W><P><L><S><F><V><L><Y><F><T><V><P><N><C><N><K><P><R><W><E><K><W><F><M><V><T><F><A><S><S><T><L><W><I><A><A><F><S><Y><M><M><V><W><M><V><T><I><I><G><Y><T><L><G><I><P><D><V><I><M><G><I><T><F><L><A><A><G><T><S><V><P><D><C><M><A><S><L><I><V><A><R><Q><G><M><G><D><M><A><V><S><N><S><I><G><S><N><V><F><D><I><L><I><G><L><G><L><P><W><A><L><Q><T><L><A><V><D><Y><G><S><Y><I><R><L><N><S><R><G><L><I><Y><S><V><G><L><L><L><A><S><V><F><V><T><V><F><G><V><H><L><N><K><W><Q><L><D><K><K><L><G><C><G><C><L><L><L><Y><G><V><F><L><C><F><S><I><M><T><E><F><N><V><F><T><F><V><N><L><P><M><C><G><D><H> | Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).<BOP> | Q9HC58 |
Q16850 | CP51A_HUMAN | Sterol 14-alpha demethylase | Homo | <M><A><A><A><A><G><M><L><L><L><G><L><L><Q><A><G><G><S><V><L><G><Q><A><M><E><K><V><T><G><G><N><L><L><S><M><L><L><I><A><C><A><F><T><L><S><L><V><Y><L><I><R><L><A><A><G><H><L><V><Q><L><P><A><G><V><K><S><P><P><Y><I><F><S><P><I><P><F><L><G><H><A><I><A><F><G><K><S><P><I><E><F><L><E><N><A><Y><E><K><Y><G><P><V><F><S><F><T><M><V><G><K><T><F><T><Y><L><L><G><S><D><A><A><A><L><L><F><N><S><K><N><E><D><L><N><A><E><D><V><Y><S><R><L><T><T><P><V><F><G><K><G><V><A><Y><D><V><P><N><P><V><F><L><E><Q><K><K><M><L><K><S><G><L><N><I><A><H><F><K><Q><H><V><S><I><I><E><K><E><T><K><E><Y><F><E><S><W><G><E><S><G><E><K><N><V><F><E><A><L><S><E><L><I><I><L><T><A><S><H><C><L><H><G><K><E><I><R><S><Q><L><N><E><K><V><A><Q><L><Y><A><D><L><D><G><G><F><S><H><A><A><W><L><L><P><G><W><L><P><L><P><S><F><R><R><R><D><R><A><H><R><E><I><K><D><I><F><Y><K><A><I><Q><K><R><R><Q><S><Q><E><K><I><D><D><I><L><Q><T><L><L><D><A><T><Y><K><D><G><R><P><L><T><D><D><E><V><A><G><M><L><I><G><L><L><L><A><G><Q><H><T><S><S><T><T><S><A><W><M><G><F><F><L><A><R><D><K><T><L><Q><K><K><C><Y><L><E><Q><K><T><V><C><G><E><N><L><P><P><L><T><Y><D><Q><L><K><D><L><N><L><L><D><R><C><I><K><E><T><L><R><L><R><P><P><I><M><I><M><M><R><M><A><R><T><P><Q><T><V><A><G><Y><T><I><P><P><G><H><Q><V><C><V><S><P><T><V><N><Q><R><L><K><D><S><W><V><E><R><L><D><F><N><P><D><R><Y><L><Q><D><N><P><A><S><G><E><K><F><A><Y><V><P><F><G><A><G><R><H><R><C><I><G><E><N><F><A><Y><V><Q><I><K><T><I><W><S><T><M><L><R><L><Y><E><F><D><L><I><D><G><Y><F><P><T><V><N><Y><T><T><M><I><H><T><P><E><N><P><V><I><R><Y><K><R><R><S><K> | A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) .<BOP> | Q16850 |
A0A0A6YYC5 | TVA14_HUMAN | T cell receptor alpha variable 14/delta variable 4 | Homo | <M><S><L><S><S><L><L><K><V><V><T><A><S><L><W><L><G><P><G><I><A><Q><K><I><T><Q><T><Q><P><G><M><F><V><Q><E><K><E><A><V><T><L><D><C><T><Y><D><T><S><D><P><S><Y><G><L><F><W><Y><K><Q><P><S><S><G><E><M><I><F><L><I><Y><Q><G><S><Y><D><Q><Q><N><A><T><E><G><R><Y><S><L><N><F><Q><K><A><R><K><S><A><N><L><V><I><S><A><S><Q><L><G><D><S><A><M><Y><F><C><A><M><R><E> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0A6YYC5 |
P26678 | PPLA_HUMAN | Cardiac phospholamban | Homo | <M><E><K><V><Q><Y><L><T><R><S><A><I><R><R><A><S><T><I><E><M><P><Q><Q><A><R><Q><K><L><Q><N><L><F><I><N><F><C><L><I><L><I><C><L><L><L><I><C><I><I><V><M><L><L> | Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) . Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.<BOP> | P26678 |
P28223 | 5HT2A_HUMAN | Serotonin receptor 2A | Homo | <M><D><I><L><C><E><E><N><T><S><L><S><S><T><T><N><S><L><M><Q><L><N><D><D><T><R><L><Y><S><N><D><F><N><S><G><E><A><N><T><S><D><A><F><N><W><T><V><D><S><E><N><R><T><N><L><S><C><E><G><C><L><S><P><S><C><L><S><L><L><H><L><Q><E><K><N><W><S><A><L><L><T><A><V><V><I><I><L><T><I><A><G><N><I><L><V><I><M><A><V><S><L><E><K><K><L><Q><N><A><T><N><Y><F><L><M><S><L><A><I><A><D><M><L><L><G><F><L><V><M><P><V><S><M><L><T><I><L><Y><G><Y><R><W><P><L><P><S><K><L><C><A><V><W><I><Y><L><D><V><L><F><S><T><A><S><I><M><H><L><C><A><I><S><L><D><R><Y><V><A><I><Q><N><P><I><H><H><S><R><F><N><S><R><T><K><A><F><L><K><I><I><A><V><W><T><I><S><V><G><I><S><M><P><I><P><V><F><G><L><Q><D><D><S><K><V><F><K><E><G><S><C><L><L><A><D><D><N><F><V><L><I><G><S><F><V><S><F><F><I><P><L><T><I><M><V><I><T><Y><F><L><T><I><K><S><L><Q><K><E><A><T><L><C><V><S><D><L><G><T><R><A><K><L><A><S><F><S><F><L><P><Q><S><S><L><S><S><E><K><L><F><Q><R><S><I><H><R><E><P><G><S><Y><T><G><R><R><T><M><Q><S><I><S><N><E><Q><K><A><C><K><V><L><G><I><V><F><F><L><F><V><V><M><W><C><P><F><F><I><T><N><I><M><A><V><I><C><K><E><S><C><N><E><D><V><I><G><A><L><L><N><V><F><V><W><I><G><Y><L><S><S><A><V><N><P><L><V><Y><T><L><F><N><K><T><Y><R><S><A><F><S><R><Y><I><Q><C><Q><Y><K><E><N><K><K><P><L><Q><L><I><L><V><N><T><I><P><A><L><A><Y><K><S><S><Q><L><Q><M><G><Q><K><K><N><S><K><Q><D><A><K><T><T><D><N><D><C><S><M><V><A><L><G><K><Q><H><S><E><E><A><S><K><D><N><S><D><G><V><N><E><K><V><S><C><V> | (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.<BOP> | P28223 |
Q9NRA1 | PDGFC_HUMAN | Platelet-derived growth factor C, receptor-binding form | Homo | <M><S><L><F><G><L><L><L><L><T><S><A><L><A><G><Q><R><Q><G><T><Q><A><E><S><N><L><S><S><K><F><Q><F><S><S><N><K><E><Q><N><G><V><Q><D><P><Q><H><E><R><I><I><T><V><S><T><N><G><S><I><H><S><P><R><F><P><H><T><Y><P><R><N><T><V><L><V><W><R><L><V><A><V><E><E><N><V><W><I><Q><L><T><F><D><E><R><F><G><L><E><D><P><E><D><D><I><C><K><Y><D><F><V><E><V><E><E><P><S><D><G><T><I><L><G><R><W><C><G><S><G><T><V><P><G><K><Q><I><S><K><G><N><Q><I><R><I><R><F><V><S><D><E><Y><F><P><S><E><P><G><F><C><I><H><Y><N><I><V><M><P><Q><F><T><E><A><V><S><P><S><V><L><P><P><S><A><L><P><L><D><L><L><N><N><A><I><T><A><F><S><T><L><E><D><L><I><R><Y><L><E><P><E><R><W><Q><L><D><L><E><D><L><Y><R><P><T><W><Q><L><L><G><K><A><F><V><F><G><R><K><S><R><V><V><D><L><N><L><L><T><E><E><V><R><L><Y><S><C><T><P><R><N><F><S><V><S><I><R><E><E><L><K><R><T><D><T><I><F><W><P><G><C><L><L><V><K><R><C><G><G><N><C><A><C><C><L><H><N><C><N><E><C><Q><C><V><P><S><K><V><T><K><K><Y><H><E><V><L><Q><L><R><P><K><T><G><V><R><G><L><H><K><S><L><T><D><V><A><L><E><H><H><E><E><C><D><C><V><C><R><G><S><T><G><G> | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.<BOP> | Q9NRA1 |
O95881 | TXD12_HUMAN | hTLP19 | Homo | <M><E><T><R><P><R><L><G><A><T><C><L><L><G><F><S><F><L><L><L><V><I><S><S><D><G><H><N><G><L><G><K><G><F><G><D><H><I><H><W><R><T><L><E><D><G><K><K><E><A><A><A><S><G><L><P><L><M><V><I><I><H><K><S><W><C><G><A><C><K><A><L><K><P><K><F><A><E><S><T><E><I><S><E><L><S><H><N><F><V><M><V><N><L><E><D><E><E><E><P><K><D><E><D><F><S><P><D><G><G><Y><I><P><R><I><L><F><L><D><P><S><G><K><V><H><P><E><I><I><N><E><N><G><N><P><S><Y><K><Y><F><Y><V><S><A><E><Q><V><V><Q><G><M><K><E><A><Q><E><R><L><T><G><D><A><F><R><K><K><H><L><E><D><E><L> | Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.<BOP> | O95881 |
Q07325 | CXCL9_HUMAN | Small-inducible cytokine B9 | Homo | <M><K><K><S><G><V><L><F><L><L><G><I><I><L><L><V><L><I><G><V><Q><G><T><P><V><V><R><K><G><R><C><S><C><I><S><T><N><Q><G><T><I><H><L><Q><S><L><K><D><L><K><Q><F><A><P><S><P><S><C><E><K><I><E><I><I><A><T><L><K><N><G><V><Q><T><C><L><N><P><D><S><A><D><V><K><E><L><I><K><K><W><E><K><Q><V><S><Q><K><K><K><Q><K><N><G><K><K><H><Q><K><K><K><V><L><K><V><R><K><S><Q><R><S><R><Q><K><K><T><T> | Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.<BOP> | Q07325 |
Q15415 | RBY1F_HUMAN | Y chromosome RNA recognition motif 2 | Homo | <M><V><E><A><D><H><P><G><K><L><F><I><G><G><L><N><R><E><T><N><E><K><M><L><K><A><V><F><G><K><H><G><P><I><S><E><V><L><L><I><K><D><R><T><S><K><S><R><G><F><A><F><I><T><F><E><N><P><A><D><A><K><N><A><A><K><D><M><N><G><T><S><L><H><G><K><A><I><K><V><E><Q><A><K><K><P><S><F><Q><S><G><G><R><R><R><P><P><A><S><S><R><N><R><S><P><S><G><S><L><R><S><A><R><G><S><S><G><G><T><R><G><W><L><P><S><H><E><G><H><L><D><D><G><G><Y><T><P><D><L><K><M><S><Y><S><R><G><L><I><P><V><K><R><G><P><S><S><R><S><G><G><P><P><P><K><K><S><A><P><S><A><V><A><R><S><N><S><W><M><G><S><Q><G><P><M><S><Q><R><R><E><N><Y><G><V><P><P><R><R><A><T><I><S><S><W><R><N><D><R><M><S><T><R><H><D><G><Y><A><T><N><D><G><N><H><P><S><C><Q><E><T><R><D><Y><A><P><P><S><R><G><Y><A><Y><R><D><N><G><H><S><N><R><D><E><H><S><S><R><G><Y><R><N><H><R><S><S><R><E><T><R><D><Y><A><P><P><S><R><G><H><A><Y><R><D><Y><G><H><S><R><R><D><E><S><Y><S><R><G><Y><R><N><H><R><S><S><R><E><T><R><E><Y><A><P><P><S><R><G><H><G><Y><R><D><Y><G><H><S><R><R><H><E><S><Y><S><R><G><Y><R><N><H><P><S><S><R><E><T><R><D><Y><A><P><P><H><R><D><Y><A><Y><R><D><Y><G><H><S><S><W><D><E><H><S><S><R><G><Y><S><Y><H><D><G><Y><G><E><A><L><G><R><D><H><S><E><H><L><S><G><S><S><Y><R><D><A><L><Q><R><Y><G><T><S><H><G><A><P><P><A><R><G><P><R><M><S><Y><G><G><S><T><C><H><A><Y><S><N><T><R><D><R><Y><G><R><S><W><E><S><Y><S><S><C><G><D><F><H><Y><C><D><R><E><H><V><C><R><K><D><Q><R><N><P><P><S><L><G><R><V><L><P><D><P><R><E><A><Y><G><S><S><S><Y><V><A><S><I><V><D><G><G><E><S><R><S><E><K><G><D><S><S><R><Y> | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.<BOP> | Q15415 |
Q9Y6N1 | COX11_HUMAN | Cytochrome c oxidase assembly protein COX11, mitochondrial | Homo | <M><G><G><L><W><R><P><G><W><R><C><V><P><F><C><G><W><R><W><I><H><P><G><S><P><T><R><A><A><E><R><V><E><P><F><L><R><P><E><W><S><G><T><G><G><A><E><R><G><L><R><W><L><G><T><W><K><R><C><S><L><R><A><R><H><P><A><L><Q><P><P><R><R><P><K><S><S><N><P><F><T><R><A><Q><E><E><E><R><R><R><Q><N><K><T><T><L><T><Y><V><A><A><V><A><V><G><M><L><G><A><S><Y><A><A><V><P><L><Y><R><L><Y><C><Q><T><T><G><L><G><G><S><A><V><A><G><H><A><S><D><K><I><E><N><M><V><P><V><K><D><R><I><I><K><I><S><F><N><A><D><V><H><A><S><L><Q><W><N><F><R><P><Q><Q><T><E><I><Y><V><V><P><G><E><T><A><L><A><F><Y><R><A><K><N><P><T><D><K><P><V><I><G><I><S><T><Y><N><I><V><P><F><E><A><G><Q><Y><F><N><K><I><Q><C><F><C><F><E><E><Q><R><L><N><P><Q><E><E><V><D><M><P><V><F><F><Y><I><D><P><E><F><A><E><D><P><R><M><I><K><V><D><L><I><T><L><S><Y><T><F><F><E><A><K><E><G><H><K><L><P><V><P><G><Y><N> | Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.<BOP> | Q9Y6N1 |
O00391 | QSOX1_HUMAN | Quiescin Q6 | Homo | <M><R><R><C><N><S><G><S><G><P><P><P><S><L><L><L><L><L><L><W><L><L><A><V><P><G><A><N><A><A><P><R><S><A><L><Y><S><P><S><D><P><L><T><L><L><Q><A><D><T><V><R><G><A><V><L><G><S><R><S><A><W><A><V><E><F><F><A><S><W><C><G><H><C><I><A><F><A><P><T><W><K><A><L><A><E><D><V><K><A><W><R><P><A><L><Y><L><A><A><L><D><C><A><E><E><T><N><S><A><V><C><R><D><F><N><I><P><G><F><P><T><V><R><F><F><K><A><F><T><K><N><G><S><G><A><V><F><P><V><A><G><A><D><V><Q><T><L><R><E><R><L><I><D><A><L><E><S><H><H><D><T><W><P><P><A><C><P><P><L><E><P><A><K><L><E><E><I><D><G><F><F><A><R><N><N><E><E><Y><L><A><L><I><F><E><K><G><G><S><Y><L><G><R><E><V><A><L><D><L><S><Q><H><K><G><V><A><V><R><R><V><L><N><T><E><A><N><V><V><R><K><F><G><V><T><D><F><P><S><C><Y><L><L><F><R><N><G><S><V><S><R><V><P><V><L><M><E><S><R><S><F><Y><T><A><Y><L><Q><R><L><S><G><L><T><R><E><A><A><Q><T><T><V><A><P><T><T><A><N><K><I><A><P><T><V><W><K><L><A><D><R><S><K><I><Y><M><A><D><L><E><S><A><L><H><Y><I><L><R><I><E><V><G><R><F><P><V><L><E><G><Q><R><L><V><A><L><K><K><F><V><A><V><L><A><K><Y><F><P><G><R><P><L><V><Q><N><F><L><H><S><V><N><E><W><L><K><R><Q><K><R><N><K><I><P><Y><S><F><F><K><T><A><L><D><D><R><K><E><G><A><V><L><A><K><K><V><N><W><I><G><C><Q><G><S><E><P><H><F><R><G><F><P><C><S><L><W><V><L><F><H><F><L><T><V><Q><A><A><R><Q><N><V><D><H><S><Q><E><A><A><K><A><K><E><V><L><P><A><I><R><G><Y><V><H><Y><F><F><G><C><R><D><C><A><S><H><F><E><Q><M><A><A><A><S><M><H><R><V><G><S><P><N><A><A><V><L><W><L><W><S><S><H><N><R><V><N><A><R><L><A><G><A><P><S><E><D><P><Q><F><P><K><V><Q><W><P><P><R><E><L><C><S><A><C><H><N><E><R><L><D><V><P><V><W><D><V><E><A><T><L><N><F><L><K><A><H><F><S><P><S><N><I><I><L><D><F><P><A><A><G><S><A><A><R><R><D><V><Q><N><V><A><A><A><P><E><L><A><M><G><A><L><E><L><E><S><R><N><S><T><L><D><P><G><K><P><E><M><M><K><S><P><T><N><T><T><P><H><V><P><A><E><G><P><E><A><S><R><P><P><K><L><H><P><G><L><R><A><A><P><G><Q><E><P><P><E><H><M><A><E><L><Q><R><N><E><Q><E><Q><P><L><G><Q><W><H><L><S><K><R><D><T><G><A><A><L><L><A><E><S><R><A><E><K><N><R><L><W><G><P><L><E><V><R><R><V><G><R><S><S><K><Q><L><V><D><I><P><E><G><Q><L><E><A><R><A><G><R><G><R><G><Q><W><L><Q><V><L><G><G><G><F><S><Y><L><D><I><S><L><C><V><G><L><Y><S><L><S><F><M><G><L><L><A><M><Y><T><Y><F><Q><A><K><I><R><A><L><K><G><H><A><G><H><P><A><A> | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide . Plays a role in disulfide bond formation in a variety of extracellular proteins . In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration .<BOP> | O00391 |
Q9BVC4 | LST8_HUMAN | Mammalian lethal with SEC13 protein 8 | Homo | <M><N><T><S><P><G><T><V><G><S><D><P><V><I><L><A><T><A><G><Y><D><H><T><V><R><F><W><Q><A><H><S><G><I><C><T><R><T><V><Q><H><Q><D><S><Q><V><N><A><L><E><V><T><P><D><R><S><M><I><A><A><A><G><Y><Q><H><I><R><M><Y><D><L><N><S><N><N><P><N><P><I><I><S><Y><D><G><V><N><K><N><I><A><S><V><G><F><H><E><D><G><R><W><M><Y><T><G><G><E><D><C><T><A><R><I><W><D><L><R><S><R><N><L><Q><C><Q><R><I><F><Q><V><N><A><P><I><N><C><V><C><L><H><P><N><Q><A><E><L><I><V><G><D><Q><S><G><A><I><H><I><W><D><L><K><T><D><H><N><E><Q><L><I><P><E><P><E><V><S><I><T><S><A><H><I><D><P><D><A><S><Y><M><A><A><V><N><S><T><G><N><C><Y><V><W><N><L><T><G><G><I><G><D><E><V><T><Q><L><I><P><K><T><K><I><P><A><H><T><R><Y><A><L><Q><C><R><F><S><P><D><S><T><L><L><A><T><C><S><A><D><Q><T><C><K><I><W><R><T><S><N><F><S><L><M><T><E><L><S><I><K><S><G><N><P><G><E><S><S><R><G><W><M><W><G><C><A><F><S><G><D><S><Q><Y><I><V><T><A><S><S><D><N><L><A><R><L><W><C><V><E><T><G><E><I><K><R><E><Y><G><G><H><Q><K><A><V><V><C><L><A><F><N><D><S><V><L><G> | Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPT | Q9BVC4 |
O14944 | EREG_HUMAN | Epiregulin | Homo | <M><T><A><G><R><R><M><E><M><L><C><A><G><R><V><P><A><L><L><L><C><L><G><F><H><L><L><Q><A><V><L><S><T><T><V><I><P><S><C><I><P><G><E><S><S><D><N><C><T><A><L><V><Q><T><E><D><N><P><R><V><A><Q><V><S><I><T><K><C><S><S><D><M><N><G><Y><C><L><H><G><Q><C><I><Y><L><V><D><M><S><Q><N><Y><C><R><C><E><V><G><Y><T><G><V><R><C><E><H><F><F><L><T><V><H><Q><P><L><S><K><E><Y><V><A><L><T><V><I><L><I><I><L><F><L><I><T><V><V><G><S><T><Y><Y><F><C><R><W><Y><R><N><R><K><S><K><E><P><K><K><E><Y><E><R><V><T><S><G><D><P><E><L><P><Q><V> | Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation . Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation .<BOP> | O14944 |
A5X5Y0 | 5HT3E_HUMAN | Serotonin receptor 3E | Homo | <M><E><G><S><W><F><H><R><K><R><F><S><F><Y><L><L><L><G><F><L><L><Q><G><R><G><V><T><F><T><I><N><C><S><G><F><G><Q><H><G><A><D><P><T><A><L><N><S><V><F><N><R><K><P><F><R><P><V><T><N><I><S><V><P><T><Q><V><N><I><S><F><A><M><S><A><I><L><D><V><N><E><Q><L><H><L><L><S><S><F><L><W><L><E><M><V><W><D><N><P><F><I><S><W><N><P><E><E><C><E><G><I><T><K><M><S><M><A><A><K><N><L><W><L><P><D><I><F><I><I><E><L><M><D><V><D><K><T><P><K><G><L><T><A><Y><V><S><N><E><G><R><I><R><Y><K><K><P><M><K><V><D><S><I><C><N><L><D><I><F><Y><F><P><F><D><Q><Q><N><C><T><L><T><F><S><S><F><L><Y><T><V><D><S><M><L><L><D><M><E><K><E><V><W><E><I><T><D><A><S><R><N><I><L><Q><T><H><G><E><W><E><L><L><G><L><S><K><A><T><A><K><L><S><R><G><G><N><L><Y><D><Q><I><V><F><Y><V><A><I><R><R><R><P><S><L><Y><V><I><N><L><L><V><P><S><G><F><L><V><A><I><D><A><L><S><F><Y><L><P><V><K><S><G><N><R><V><P><F><K><I><T><L><L><L><G><Y><N><V><F><L><L><M><M><S><D><L><L><P><T><S><G><T><P><L><I><G><V><Y><F><A><L><C><L><S><L><M><V><G><S><L><L><E><T><I><F><I><T><H><L><L><H><V><A><T><T><Q><P><P><P><L><P><R><W><L><H><S><L><L><L><H><C><N><S><P><G><R><C><C><P><T><A><P><Q><K><E><N><K><G><P><G><L><T><P><T><H><L><P><G><V><K><E><P><E><V><S><A><G><Q><M><P><G><P><A><E><A><E><L><T><G><G><S><E><W><T><R><A><Q><R><E><H><E><A><Q><K><Q><H><S><V><E><L><W><L><Q><F><S><H><A><M><D><A><M><L><F><R><L><Y><L><L><F><M><A><S><S><I><I><T><V><I><C><L><W><N><T> | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.<BOP> | A5X5Y0 |
O15212 | PFD6_HUMAN | Protein Ke2 | Homo | <M><A><E><L><I><Q><K><K><L><Q><G><E><V><E><K><Y><Q><Q><L><Q><K><D><L><S><K><S><M><S><G><R><Q><K><L><E><A><Q><L><T><E><N><N><I><V><K><E><E><L><A><L><L><D><G><S><N><V><V><F><K><L><L><G><P><V><L><V><K><Q><E><L><G><E><A><R><A><T><V><G><K><R><L><D><Y><I><T><A><E><I><K><R><Y><E><S><Q><L><R><D><L><E><R><Q><S><E><Q><Q><R><E><T><L><A><Q><L><Q><Q><E><F><Q><R><A><Q><A><A><K><A><G><A><P><G><K><A> | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.<BOP> | O15212 |
Q92529 | SHC3_HUMAN | Src homology 2 domain-containing-transforming protein C3 | Homo | <M><L><P><R><T><K><Y><N><R><F><R><N><D><S><V><T><S><V><D><D><L><L><H><S><L><S><V><S><G><G><G><G><K><V><S><A><A><R><A><T><P><A><A><A><P><Y><L><V><S><G><E><A><L><R><K><A><P><D><D><G><P><G><S><L><G><H><L><L><H><K><V><S><H><L><K><L><S><S><S><G><L><R><G><L><S><S><A><A><R><E><R><A><G><A><R><L><S><G><S><C><S><A><P><S><L><A><A><P><D><G><S><A><P><S><A><P><R><A><P><A><M><S><A><A><R><K><G><R><P><G><D><E><P><L><P><R><P><P><R><G><A><P><H><A><S><D><Q><V><L><G><P><G><V><T><Y><V><V><K><Y><L><G><C><I><E><V><L><R><S><M><R><S><L><D><F><S><T><R><T><Q><I><T><R><E><A><I><S><R><V><C><E><A><V><P><G><A><K><G><A><F><K><K><R><K><P><P><S><K><M><L><S><S><I><L><G><K><S><N><L><Q><F><A><G><M><S><I><S><L><T><I><S><T><A><S><L><N><L><R><T><P><D><S><K><Q><I><I><A><N><H><H><M><R><S><I><S><F><A><S><G><G><D><P><D><T><T><D><Y><V><A><Y><V><A><K><D><P><V><N><R><R><A><C><H><I><L><E><C><C><D><G><L><A><Q><D><V><I><G><S><I><G><Q><A><F><E><L><R><F><K><Q><Y><L><Q><C><P><T><K><I><P><A><L><H><D><R><M><Q><S><L><D><E><P><W><T><E><E><E><G><D><G><S><D><H><P><Y><Y><N><S><I><P><S><K><M><P><P><P><G><G><F><L><D><T><R><L><K><P><R><P><H><A><P><D><T><A><Q><F><A><G><K><E><Q><T><Y><Y><Q><G><R><H><L><G><D><T><F><G><E><D><W><Q><Q><T><P><L><R><Q><G><S><S><D><I><Y><S><T><P><E><G><K><L><H><V><A><P><T><G><E><A><P><T><Y><V><N><T><Q><Q><I><P><P><Q><A><W><P><A><A><V><S><S><A><E><S><S><P><R><K><D><L><F><D><M><K><P><F><E><D><A><L><K><N><Q><P><L><G><P><V><L><S><K><A><A><S><V><E><C><I><S><P><V><S><P><R><A><P><D><A><K><M><L><E><E><L><Q><A><E><T><W><Y><Q><G><E><M><S><R><K><E><A><E><G><L><L><E><K><D><G><D><F><L><V><R><K><S><T><T><N><P><G><S><F><V><L><T><G><M><H><N><G><Q><A><K><H><L><L><L><V><D><P><E><G><T><I><R><T><K><D><R><V><F><D><S><I><S><H><L><I><N><H><H><L><E><S><S><L><P><I><V><S><A><G><S><E><L><C><L><Q><Q><P><V><E><R><K><Q> | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.<BOP> | Q92529 |
Q8N807 | PDILT_HUMAN | Protein disulfide-isomerase-like protein of the testis | Homo | <M><D><L><L><W><M><P><L><L><L><V><A><A><C><V><S><A><V><H><S><S><P><E><V><N><A><G><V><S><S><I><H><I><T><K><P><V><H><I><L><E><E><R><S><L><L><V><L><T><P><A><G><L><T><Q><M><L><N><Q><T><R><F><L><M><V><L><F><H><N><P><S><S><K><Q><S><R><N><L><A><E><E><L><G><K><A><V><E><I><M><G><K><G><K><N><G><I><G><F><G><K><V><D><I><T><I><E><K><E><L><Q><Q><E><F><G><I><T><K><A><P><E><L><K><L><F><F><E><G><N><R><S><E><P><I><S><C><K><G><V><V><E><S><A><A><L><V><V><W><L><R><R><Q><I><S><Q><K><A><F><L><F><N><S><S><E><Q><V><A><E><F><V><I><S><R><P><L><V><I><V><G><F><F><Q><D><L><E><E><E><V><A><E><L><F><Y><D><V><I><K><D><F><P><E><L><T><F><G><V><I><T><I><G><N><V><I><G><R><F><H><V><T><L><D><S><V><L><V><F><K><K><G><K><I><V><N><R><Q><K><L><I><N><D><S><T><N><K><Q><E><L><N><R><V><I><K><Q><H><L><T><D><F><V><I><E><Y><N><T><E><N><K><D><L><I><S><E><L><H><I><M><S><H><M><L><L><F><V><S><K><S><S><E><S><Y><G><I><I><I><Q><H><Y><K><L><A><S><K><E><F><Q><N><K><I><L><F><I><L><V><D><A><D><E><P><R><N><G><R><V><F><K><Y><F><R><V><T><E><V><D><I><P><S><V><Q><I><L><N><L><S><S><D><A><R><Y><K><M><P><S><D><D><I><T><Y><E><S><L><K><K><F><G><R><S><F><L><S><K><N><A><T><K><H><Q><S><S><E><E><I><P><K><Y><W><D><Q><G><L><V><K><Q><L><V><G><K><N><F><N><V><V><V><F><D><K><E><K><D><V><F><V><M><F><Y><A><P><W><S><K><K><C><K><M><L><F><P><L><L><E><E><L><G><R><K><Y><Q><N><H><S><T><I><I><I><A><K><I><D><V><T><A><N><D><I><Q><L><M><Y><L><D><R><Y><P><F><F><R><L><F><P><S><G><S><Q><Q><A><V><L><Y><K><G><E><H><T><L><K><G><F><S><D><F><L><E><S><H><I><K><T><K><I><E><D><E><D><E><L><L><S><V><E><Q><N><E><V><I><E><E><E><V><L><A><E><E><K><E><V><P><M><M><R><K><G><L><P><E><Q><Q><S><P><E><L><E><N><M><T><K><Y><V><S><K><L><E><E><P><A><G><K><K><K><T><S><E><E><V><V><V><V><V><A><K><P><K><G><P><P><V><Q><K><K><K><P><K><V><K><E><E><L> | Probable redox-inactive chaperone involved in spermatogenesis.<BOP> | Q8N807 |
Q86YW0 | PLCZ1_HUMAN | Testis-development protein NYD-SP27 | Homo | <M><E><M><R><W><F><L><S><K><I><Q><D><D><F><R><G><G><K><I><N><L><E><K><T><Q><R><L><L><E><K><L><D><I><R><C><S><Y><I><H><V><K><Q><I><F><K><D><N><D><R><L><K><Q><G><R><I><T><I><E><E><F><R><A><I><Y><R><I><I><T><H><R><E><E><I><I><E><I><F><N><T><Y><S><E><N><R><K><I><L><L><A><S><N><L><A><Q><F><L><T><Q><E><Q><Y><A><A><E><M><S><K><A><I><A><F><E><I><I><Q><K><Y><E><P><I><E><E><V><R><K><A><H><Q><M><S><L><E><G><F><T><R><Y><M><D><S><R><E><C><L><L><F><K><N><E><C><R><K><V><Y><Q><D><M><T><H><P><L><N><D><Y><F><I><S><S><S><H><N><T><Y><L><V><S><D><Q><L><L><G><P><S><D><L><W><G><Y><V><S><A><L><V><K><G><C><R><C><L><E><I><D><C><W><D><G><A><Q><N><E><P><V><V><Y><H><G><Y><T><L><T><S><K><L><L><F><K><T><V><I><Q><A><I><H><K><Y><A><F><M><T><S><D><Y><P><V><V><L><S><L><E><N><H><C><S><T><A><Q><Q><E><V><M><A><D><N><L><Q><A><T><F><G><E><S><L><L><S><D><M><L><D><D><F><P><D><T><L><P><S><P><E><A><L><K><F><K><I><L><V><K><N><K><K><I><G><T><L><K><E><T><H><E><R><K><G><S><D><K><R><G><D><N><Q><D><K><E><T><G><V><K><K><L><P><G><V><M><L><F><K><K><K><K><T><R><K><L><K><I><A><L><A><L><S><D><L><V><I><Y><T><K><A><E><K><F><K><S><F><Q><H><S><R><L><Y><Q><Q><F><N><E><N><N><S><I><G><E><T><Q><A><R><K><L><S><K><L><R><V><H><E><F><I><F><H><T><R><K><F><I><T><R><I><Y><P><K><A><T><R><A><D><S><S><N><F><N><P><Q><E><F><W><N><I><G><C><Q><M><V><A><L><N><F><Q><T><P><G><L><P><M><D><L><Q><N><G><K><F><L><D><N><G><G><S><G><Y><I><L><K><P><H><F><L><R><E><S><K><S><Y><F><N><P><S><N><I><K><E><G><M><P><I><T><L><T><I><R><L><I><S><G><I><Q><L><P><L><T><H><S><S><S><N><K><G><D><S><L><V><I><I><E><V><F><G><V><P><N><D><Q><M><K><Q><Q><T><R><V><I><K><K><N><A><F><S><P><R><W><N><E><T><F><T><F><I><I><H><V><P><E><L><A><L><I><R><F><V><V><E><G><Q><G><L><I><A><G><N><E><F><L><G><Q><Y><T><L><P><L><L><C><M><N><K><G><Y><R><R><I><P><L><F><S><R><M><G><E><S><L><E><P><A><S><L><F><V><Y><V><W><Y><V><R> | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.<BOP> | Q86YW0 |
Q8TCB6 | O51E1_HUMAN | Prostate-specific G protein-coupled receptor 2 | Homo | <M><V><D><P><N><G><N><E><S><S><A><T><Y><F><I><L><I><G><L><P><G><L><E><E><A><Q><F><W><L><A><F><P><L><C><S><L><Y><L><I><A><V><L><G><N><L><T><I><I><Y><I><V><R><T><E><H><S><L><H><E><P><M><Y><I><F><L><C><M><L><S><G><I><D><I><L><I><S><T><S><S><M><P><K><M><L><A><I><F><W><F><N><S><T><T><I><Q><F><D><A><C><L><L><Q><M><F><A><I><H><S><L><S><G><M><E><S><T><V><L><L><A><M><A><F><D><R><Y><V><A><I><C><H><P><L><R><H><A><T><V><L><T><L><P><R><V><T><K><I><G><V><A><A><V><V><R><G><A><A><L><M><A><P><L><P><V><F><I><K><Q><L><P><F><C><R><S><N><I><L><S><H><S><Y><C><L><H><Q><D><V><M><K><L><A><C><D><D><I><R><V><N><V><V><Y><G><L><I><V><I><I><S><A><I><G><L><D><S><L><L><I><S><F><S><Y><L><L><I><L><K><T><V><L><G><L><T><R><E><A><Q><A><K><A><F><G><T><C><V><S><H><V><C><A><V><F><I><F><Y><V><P><F><I><G><L><S><M><V><H><R><F><S><K><R><R><D><S><P><L><P><V><I><L><A><N><I><Y><L><L><V><P><P><V><L><N><P><I><V><Y><G><V><K><T><K><E><I><R><Q><R><I><L><R><L><F><H><V><A><T><H><A><S><E><P> | Odorant receptor.<BOP> | Q8TCB6 |
O95453 | PARN_HUMAN | Polyadenylate-specific ribonuclease | Homo | <M><E><I><I><R><S><N><F><K><S><N><L><H><K><V><Y><Q><A><I><E><E><A><D><F><F><A><I><D><G><E><F><S><G><I><S><D><G><P><S><V><S><A><L><T><N><G><F><D><T><P><E><E><R><Y><Q><K><L><K><K><H><S><M><D><F><L><L><F><Q><F><G><L><C><T><F><K><Y><D><Y><T><D><S><K><Y><I><T><K><S><F><N><F><Y><V><F><P><K><P><F><N><R><S><S><P><D><V><K><F><V><C><Q><S><S><S><I><D><F><L><A><S><Q><G><F><D><F><N><K><V><F><R><N><G><I><P><Y><L><N><Q><E><E><E><R><Q><L><R><E><Q><Y><D><E><K><R><S><Q><A><N><G><A><G><A><L><S><Y><V><S><P><N><T><S><K><C><P><V><T><I><P><E><D><Q><K><K><F><I><D><Q><V><V><E><K><I><E><D><L><L><Q><S><E><E><N><K><N><L><D><L><E><P><C><T><G><F><Q><R><K><L><I><Y><Q><T><L><S><W><K><Y><P><K><G><I><H><V><E><T><L><E><T><E><K><K><E><R><Y><I><V><I><S><K><V><D><E><E><E><R><K><R><R><E><Q><Q><K><H><A><K><E><Q><E><E><L><N><D><A><V><G><F><S><R><V><I><H><A><I><A><N><S><G><K><L><V><I><G><H><N><M><L><L><D><V><M><H><T><V><H><Q><F><Y><C><P><L><P><A><D><L><S><E><F><K><E><M><T><T><C><V><F><P><R><L><L><D><T><K><L><M><A><S><T><Q><P><F><K><D><I><I><N><N><T><S><L><A><E><L><E><K><R><L><K><E><T><P><F><N><P><P><K><V><E><S><A><E><G><F><P><S><Y><D><T><A><S><E><Q><L><H><E><A><G><Y><D><A><Y><I><T><G><L><C><F><I><S><M><A><N><Y><L><G><S><F><L><S><P><P><K><I><H><V><S><A><R><S><K><L><I><E><P><F><F><N><K><L><F><L><M><R><V><M><D><I><P><Y><L><N><L><E><G><P><D><L><Q><P><K><R><D><H><V><L><H><V><T><F><P><K><E><W><K><T><S><D><L><Y><Q><L><F><S><A><F><G><N><I><Q><I><S><W><I><D><D><T><S><A><F><V><S><L><S><Q><P><E><Q><V><K><I><A><V><N><T><S><K><Y><A><E><S><Y><R><I><Q><T><Y><A><E><Y><M><G><R><K><Q><E><E><K><Q><I><K><R><K><W><T><E><D><S><W><K><E><A><D><S><K><R><L><N><P><Q><C><I><P><Y><T><L><Q><N><H><Y><Y><R><N><N><S><F><T><A><P><S><T><V><G><K><R><N><L><S><P><S><Q><E><E><A><G><L><E><D><G><V><S><G><E><I><S><D><T><E><L><E><Q><T><D><S><C><A><E><P><L><S><E><G><R><K><K><A><K><K><L><K><R><M><K><K><E><L><S><P><A><G><S><I><S><K><N><S><P><A><T><L><F><E><V><P><D><T><W> | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization . Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA | O95453 |
P33993 | MCM7_HUMAN | P1.1-MCM3 | Homo | <M><A><L><K><D><Y><A><L><E><K><E><K><V><K><K><F><L><Q><E><F><Y><Q><D><D><E><L><G><K><K><Q><F><K><Y><G><N><Q><L><V><R><L><A><H><R><E><Q><V><A><L><Y><V><D><L><D><D><V><A><E><D><D><P><E><L><V><D><S><I><C><E><N><A><R><R><Y><A><K><L><F><A><D><A><V><Q><E><L><L><P><Q><Y><K><E><R><E><V><V><N><K><D><V><L><D><V><Y><I><E><H><R><L><M><M><E><Q><R><S><R><D><P><G><M><V><R><S><P><Q><N><Q><Y><P><A><E><L><M><R><R><F><E><L><Y><F><Q><G><P><S><S><N><K><P><R><V><I><R><E><V><R><A><D><S><V><G><K><L><V><T><V><R><G><I><V><T><R><V><S><E><V><K><P><K><M><V><V><A><T><Y><T><C><D><Q><C><G><A><E><T><Y><Q><P><I><Q><S><P><T><F><M><P><L><I><M><C><P><S><Q><E><C><Q><T><N><R><S><G><G><R><L><Y><L><Q><T><R><G><S><R><F><I><K><F><Q><E><M><K><M><Q><E><H><S><D><Q><V><P><V><G><N><I><P><R><S><I><T><V><L><V><E><G><E><N><T><R><I><A><Q><P><G><D><H><V><S><V><T><G><I><F><L><P><I><L><R><T><G><F><R><Q><V><V><Q><G><L><L><S><E><T><Y><L><E><A><H><R><I><V><K><M><N><K><S><E><D><D><E><S><G><A><G><E><L><T><R><E><E><L><R><Q><I><A><E><E><D><F><Y><E><K><L><A><A><S><I><A><P><E><I><Y><G><H><E><D><V><K><K><A><L><L><L><L><L><V><G><G><V><D><Q><S><P><R><G><M><K><I><R><G><N><I><N><I><C><L><M><G><D><P><G><V><A><K><S><Q><L><L><S><Y><I><D><R><L><A><P><R><S><Q><Y><T><T><G><R><G><S><S><G><V><G><L><T><A><A><V><L><R><D><S><V><S><G><E><L><T><L><E><G><G><A><L><V><L><A><D><Q><G><V><C><C><I><D><E><F><D><K><M><A><E><A><D><R><T><A><I><H><E><V><M><E><Q><Q><T><I><S><I><A><K><A><G><I><L><T><T><L><N><A><R><C><S><I><L><A><A><A><N><P><A><Y><G><R><Y><N><P><R><R><S><L><E><Q><N><I><Q><L><P><A><A><L><L><S><R><F><D><L><L><W><L><I><Q><D><R><P><D><R><D><N><D><L><R><L><A><Q><H><I><T><Y><V><H><Q><H><S><R><Q><P><P><S><Q><F><E><P><L><D><M><K><L><M><R><R><Y><I><A><M><C><R><E><K><Q><P><M><V><P><E><S><L><A><D><Y><I><T><A><A><Y><V><E><M><R><R><E><A><W><A><S><K><D><A><T><Y><T><S><A><R><T><L><L><A><I><L><R><L><S><T><A><L><A><R><L><R><M><V><D><V><V><E><K><E><D><V><N><E><A><I><R><L><M><E><M><S><K><D><S><L><L><G><D><K><G><Q><T><A><R><T><Q><R><P><A><D><V><I><F><A><T><V><R><E><L><V><S><G><G><R><S><V><R><F><S><E><A><E><Q><R><C><V><S><R><G><F><T><P><A><Q><F><Q><A><A><L><D><E><Y><E><E><L><N><V><W><Q><V><N><A><S><R><T><R><I><T><F><V> | Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built . The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity . Required for S-phase checkpoint activation upon UV-induced damage.<BOP> | P33993 |
O00442 | RTCA_HUMAN | RNA terminal phosphate cyclase domain-containing protein 1 | Homo | <M><A><G><P><R><V><E><V><D><G><S><I><M><E><G><G><G><Q><I><L><R><V><S><T><A><L><S><C><L><L><G><L><P><L><R><V><Q><K><I><R><A><G><R><S><T><P><G><L><R><P><Q><H><L><S><G><L><E><M><I><R><D><L><C><D><G><Q><L><E><G><A><E><I><G><S><T><E><I><T><F><T><P><E><K><I><K><G><G><I><H><T><A><D><T><K><T><A><G><S><V><C><L><L><M><Q><V><S><M><P><C><V><L><F><A><A><S><P><S><E><L><H><L><K><G><G><T><N><A><E><M><A><P><Q><I><D><Y><T><V><M><V><F><K><P><I><V><E><K><F><G><F><I><F><N><C><D><I><K><T><R><G><Y><Y><P><K><G><G><G><E><V><I><V><R><M><S><P><V><K><Q><L><N><P><I><N><L><T><E><R><G><C><V><T><K><I><Y><G><R><A><F><V><A><G><V><L><P><F><K><V><A><K><D><M><A><A><A><A><V><R><C><I><R><K><E><I><R><D><L><Y><V><N><I><Q><P><V><Q><E><P><K><D><Q><A><F><G><N><G><N><G><I><I><I><I><A><E><T><S><T><G><C><L><F><A><G><S><S><L><G><K><R><G><V><N><A><D><K><V><G><I><E><A><A><E><M><L><L><A><N><L><R><H><G><G><T><V><D><E><Y><L><Q><D><Q><L><I><V><F><M><A><L><A><N><G><V><S><R><I><K><T><G><P><V><T><L><H><T><Q><T><A><I><H><F><A><E><Q><I><A><K><A><K><F><I><V><K><K><S><E><D><E><E><D><A><A><K><D><T><Y><I><I><E><C><Q><G><I><G><M><T><N><P><N><L> | Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.<BOP> | O00442 |
O00590 | ACKR2_HUMAN | Chemokine-binding protein D6 | Homo | <M><A><A><T><A><S><P><Q><P><L><A><T><E><D><A><D><S><E><N><S><S><F><Y><Y><Y><D><Y><L><D><E><V><A><F><M><L><C><R><K><D><A><V><V><S><F><G><K><V><F><L><P><V><F><Y><S><L><I><F><V><L><G><L><S><G><N><L><L><L><L><M><V><L><L><R><Y><V><P><R><R><R><M><V><E><I><Y><L><L><N><L><A><I><S><N><L><L><F><L><V><T><L><P><F><W><G><I><S><V><A><W><H><W><V><F><G><S><F><L><C><K><M><V><S><T><L><Y><T><I><N><F><Y><S><G><I><F><F><I><S><C><M><S><L><D><K><Y><L><E><I><V><H><A><Q><P><Y><H><R><L><R><T><R><A><K><S><L><L><L><A><T><I><V><W><A><V><S><L><A><V><S><I><P><D><M><V><F><V><Q><T><H><E><N><P><K><G><V><W><N><C><H><A><D><F><G><G><H><G><T><I><W><K><L><F><L><R><F><Q><Q><N><L><L><G><F><L><L><P><L><L><A><M><I><F><F><Y><S><R><I><G><C><V><L><V><R><L><R><P><A><G><Q><G><R><A><L><K><I><A><A><A><L><V><V><A><F><F><V><L><W><F><P><Y><N><L><T><L><F><L><H><T><L><L><D><L><Q><V><F><G><N><C><E><V><S><Q><H><L><D><Y><A><L><Q><V><T><E><S><I><A><F><L><H><C><C><F><S><P><I><L><Y><A><F><S><S><H><R><F><R><Q><Y><L><K><A><F><L><A><A><V><L><G><W><H><L><A><P><G><T><A><Q><A><S><L><S><S><C><S><E><S><S><I><L><T><A><Q><E><E><M><T><G><M><N><D><L><G><E><R><Q><S><E><N><Y><P><N><K><E><D><V><G><N><K><S><A> | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACK | O00590 |
Q6P1K1 | HRG1_HUMAN | Solute carrier family 48 member 1 | Homo | <M><A><P><S><R><L><Q><L><G><L><R><A><A><Y><S><G><I><S><S><V><A><G><F><S><I><F><L><V><W><T><V><V><Y><R><Q><P><G><T><A><A><M><G><G><L><A><G><V><L><A><L><W><V><L><V><T><H><V><M><Y><M><Q><D><Y><W><R><T><W><L><K><G><L><R><G><F><F><F><V><G><V><L><F><S><A><V><S><I><A><A><F><C><T><F><L><V><L><A><I><T><R><H><Q><S><L><T><D><P><T><S><Y><Y><L><S><S><V><W><S><F><I><S><F><K><W><A><F><L><L><S><L><Y><A><H><R><Y><R><A><D><F><A><D><I><S><I><L><S><D><F> | Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.<BOP> | Q6P1K1 |
Q9UQV4 | LAMP3_HUMAN | Protein TSC403 | Homo | <M><P><R><Q><L><S><A><A><A><A><L><F><A><S><L><A><V><I><L><H><D><G><S><Q><M><R><A><K><A><F><P><E><T><R><D><Y><S><Q><P><T><A><A><A><T><V><Q><D><I><K><K><P><V><Q><Q><P><A><K><Q><A><P><H><Q><T><L><A><A><R><F><M><D><G><H><I><T><F><Q><T><A><A><T><V><K><I><P><T><T><T><P><A><T><T><K><N><T><A><T><T><S><P><I><T><Y><T><L><V><T><T><Q><A><T><P><N><N><S><H><T><A><P><P><V><T><E><V><T><V><G><P><S><L><A><P><Y><S><L><P><P><T><I><T><P><P><A><H><T><T><G><T><S><S><S><T><V><S><H><T><T><G><N><T><T><Q><P><S><N><Q><T><T><L><P><A><T><L><S><I><A><L><H><K><S><T><T><G><Q><K><P><V><Q><P><T><H><A><P><G><T><T><A><A><A><H><N><T><T><R><T><A><A><P><A><S><T><V><P><G><P><T><L><A><P><Q><P><S><S><V><K><T><G><I><Y><Q><V><L><N><G><S><R><L><C><I><K><A><E><M><G><I><Q><L><I><V><Q><D><K><E><S><V><F><S><P><R><R><Y><F><N><I><D><P><N><A><T><Q><A><S><G><N><C><G><T><R><K><S><N><L><L><L><N><F><Q><G><G><F><V><N><L><T><F><T><K><D><E><E><S><Y><Y><I><S><E><V><G><A><Y><L><T><V><S><D><P><E><T><I><Y><Q><G><I><K><H><A><V><V><M><F><Q><T><A><V><G><H><S><F><K><C><V><S><E><Q><S><L><Q><L><S><A><H><L><Q><V><K><T><T><D><V><Q><L><Q><A><F><D><F><E><D><D><H><F><G><N><V><D><E><C><S><S><D><Y><T><I><V><L><P><V><I><G><A><I><V><V><G><L><C><L><M><G><M><G><V><Y><K><I><R><L><R><C><Q><S><S><G><Y><Q><R><I> | (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium.<BOP> | Q9UQV4 |
Q8NG06 | TRI58_HUMAN | Tripartite motif-containing protein 58 | Homo | <M><A><W><A><P><P><G><E><R><L><R><E><D><A><R><C><P><V><C><L><D><F><L><Q><E><P><V><S><V><D><C><G><H><S><F><C><L><R><C><I><S><E><F><C><E><K><S><D><G><A><Q><G><G><V><Y><A><C><P><Q><C><R><G><P><F><R><P><S><G><F><R><P><N><R><Q><L><A><G><L><V><E><S><V><R><R><L><G><L><G><A><G><P><G><A><R><R><C><A><R><H><G><E><D><L><S><R><F><C><E><E><D><E><A><A><L><C><W><V><C><D><A><G><P><E><H><R><T><H><R><T><A><P><L><Q><E><A><A><G><S><Y><Q><V><K><L><Q><M><A><L><E><L><M><R><K><E><L><E><D><A><L><T><Q><E><A><N><V><G><K><K><T><V><I><W><K><E><K><V><E><M><Q><R><Q><R><F><R><L><E><F><E><K><H><R><G><F><L><A><Q><E><E><Q><R><Q><L><R><R><L><E><A><E><E><R><A><T><L><Q><R><L><R><E><S><K><S><R><L><V><Q><Q><S><K><A><L><K><E><L><A><D><E><L><Q><E><R><C><Q><R><P><A><L><G><L><L><E><G><V><R><G><V><L><S><R><S><K><A><V><T><R><L><E><A><E><N><I><P><M><E><L><K><T><A><C><C><I><P><G><R><R><E><L><L><R><K><F><Q><V><D><V><K><L><D><P><A><T><A><H><P><S><L><L><L><T><A><D><L><R><S><V><Q><D><G><E><P><W><R><D><V><P><N><N><P><E><R><F><D><T><W><P><C><I><L><G><L><Q><S><F><S><S><G><R><H><Y><W><E><V><L><V><G><E><G><A><E><W><G><L><G><V><C><Q><D><T><L><P><R><K><G><E><T><T><P><S><P><E><N><G><V><W><A><L><W><L><L><K><G><N><E><Y><M><V><L><A><S><P><S><V><P><L><L><Q><L><E><S><P><R><C><I><G><I><F><L><D><Y><E><A><G><E><I><S><F><Y><N><V><T><D><G><S><Y><I><Y><T><F><N><Q><L><F><S><G><L><L><R><P><Y><F><F><I><C><D><A><T><P><L><I><L><P><P><T><T><I><A><G><S><G><N><W><A><S><R><D><H><L><D><P><A><S><D><V><R><D><D><H><L> | E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.<BOP> | Q8NG06 |
Q8TB45 | DPTOR_HUMAN | DEP domain-containing protein 6 | Homo | <M><E><E><G><G><S><T><G><S><A><G><S><D><S><S><T><S><G><S><G><G><A><Q><Q><R><E><L><E><R><M><A><E><V><L><V><T><G><E><Q><L><R><L><R><L><H><E><E><K><V><I><K><D><R><R><H><H><L><K><T><Y><P><N><C><F><V><A><K><E><L><I><D><W><L><I><E><H><K><E><A><S><D><R><E><T><A><I><K><L><M><Q><K><L><A><D><R><G><I><I><H><H><V><C><D><E><H><K><E><F><K><D><V><K><L><F><Y><R><F><R><K><D><D><G><T><F><P><L><D><N><E><V><K><A><F><M><R><G><Q><R><L><Y><E><K><L><M><S><P><E><N><T><L><L><Q><P><R><E><E><E><G><V><K><Y><E><R><T><F><M><A><S><E><F><L><D><W><L><V><Q><E><G><E><A><T><T><R><K><E><A><E><Q><L><C><H><R><L><M><E><H><G><I><I><Q><H><V><S><N><K><H><P><F><V><D><S><N><L><L><Y><Q><F><R><M><N><F><R><R><R><R><R><L><M><E><L><L><N><E><K><S><P><S><S><Q><E><T><H><D><S><P><F><C><L><R><K><Q><S><H><D><N><R><K><S><T><S><F><M><S><V><S><P><S><K><E><I><K><I><V><S><A><V><R><R><S><S><M><S><S><C><G><S><S><G><Y><F><S><S><S><P><T><L><S><S><S><P><P><V><L><C><N><P><K><S><V><L><K><R><P><V><T><S><E><E><L><L><T><P><G><A><P><Y><A><R><K><T><F><T><I><V><G><D><A><V><G><W><G><F><V><V><R><G><S><K><P><C><H><I><Q><A><V><D><P><S><G><P><A><A><A><A><G><M><K><V><C><Q><F><V><V><S><V><N><G><L><N><V><L><H><V><D><Y><R><T><V><S><N><L><I><L><T><G><P><R><T><I><V><M><E><V><M><E><E><L><E><C> | Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.<BOP> | Q8TB45 |
Q7KZN9 | COX15_HUMAN | Cytochrome c oxidase assembly protein COX15 homolog | Homo | <M><Q><R><L><L><F><P><P><L><R><A><L><K><G><R><Q><Y><L><P><L><L><A><P><R><A><A><P><R><A><Q><C><D><C><I><R><R><P><L><R><P><G><Q><Y><S><T><I><S><E><V><A><L><Q><S><G><R><G><T><V><S><L><P><S><K><A><A><E><R><V><V><G><R><W><L><L><V><C><S><G><T><V><A><G><A><V><I><L><G><G><V><T><R><L><T><E><S><G><L><S><M><V><D><W><H><L><I><K><E><M><K><P><P><T><S><Q><E><E><W><E><A><E><F><Q><R><Y><Q><Q><F><P><E><F><K><I><L><N><H><D><M><T><L><T><E><F><K><F><I><W><Y><M><E><Y><S><H><R><M><W><G><R><L><V><G><L><V><Y><I><L><P><A><A><Y><F><W><R><K><G><W><L><S><R><G><M><K><G><R><V><L><A><L><C><G><L><V><C><F><Q><G><L><L><G><W><Y><M><V><K><S><G><L><E><E><K><S><D><S><H><D><I><P><R><V><S><Q><Y><R><L><A><A><H><L><G><S><A><L><V><L><Y><C><A><S><L><W><T><S><L><S><L><L><L><P><P><H><K><L><P><E><T><H><Q><L><L><Q><L><R><R><F><A><H><G><T><A><G><L><V><F><L><T><A><L><S><G><A><F><V><A><G><L><D><A><G><L><V><Y><N><S><F><P><K><M><G><E><S><W><I><P><E><D><L><F><T><F><S><P><I><L><R><N><V><F><E><N><P><T><M><V><Q><F><D><H><R><I><L><G><I><T><S><V><T><A><I><T><V><L><Y><F><L><S><R><R><I><P><L><P><R><R><T><K><M><A><A><V><T><L><L><A><L><A><Y><T><Q><V><G><L><G><I><S><T><L><L><M><Y><V><P><T><P><L><A><A><T><H><Q><S><G><S><L><A><L><L><T><G><A><L><W><L><M><N><E><L><R><R><V><P><K> | May be involved in the biosynthesis of heme A.<BOP> | Q7KZN9 |
A0A1B0GXF2 | TVB72_HUMAN | T cell receptor beta variable 7-2 | Homo | <M><G><T><R><L><L><F><W><V><A><F><C><L><L><G><A><D><H><T><G><A><G><V><S><Q><S><P><S><N><K><V><T><E><K><G><K><D><V><E><L><R><C><D><P><I><S><G><H><T><A><L><Y><W><Y><R><Q><S><L><G><Q><G><L><E><F><L><I><Y><F><Q><G><N><S><A><P><D><K><S><G><L><P><S><D><R><F><S><A><E><R><T><G><G><S><V><S><T><L><T><I><Q><R><T><Q><Q><E><D><S><A><V><Y><L><C><A><S><S><L> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A1B0GXF2 |
Q5T5D7 | ZN684_HUMAN | Zinc finger protein 684 | Homo | <M><I><S><F><Q><E><S><V><T><F><Q><D><V><A><V><D><F><T><A><E><E><W><Q><L><L><D><C><A><E><R><T><L><Y><W><D><V><M><L><E><N><Y><R><N><L><I><S><V><G><C><P><I><T><K><T><K><V><I><L><K><V><E><Q><G><Q><E><P><W><M><V><E><G><A><N><P><H><E><S><S><P><E><S><D><Y><P><L><V><D><E><P><G><K><H><R><E><S><K><D><N><F><L><K><S><V><L><L><T><F><N><K><I><L><T><M><E><R><I><H><H><Y><N><M><S><T><S><L><N><P><M><R><K><K><S><Y><K><S><F><E><K><C><L><P><P><N><L><D><L><L><K><Y><N><R><S><Y><T><V><E><N><A><Y><E><C><S><E><C><G><K><A><F><K><K><K><F><H><F><I><R><H><E><K><N><H><T><R><K><K><P><F><E><C><N><D><C><G><K><A><Y><S><R><K><A><H><L><A><T><H><Q><K><I><H><N><G><E><R><P><F><V><C><N><D><C><G><K><A><F><M><H><K><A><Q><L><V><V><H><Q><R><L><H><T><G><E><K><P><Y><E><C><S><Q><C><G><K><T><F><T><W><N><S><S><F><N><Q><H><V><K><S><H><T><L><E><K><S><F><E><C><K><E><C><G><K><T><F><R><Y><S><S><S><L><Y><K><H><S><R><F><H><T><G><E><K><P><Y><Q><C><I><I><C><G><K><A><F><G><N><T><S><V><L><V><T><H><Q><R><I><H><T><G><E><K><P><Y><S><C><I><E><C><G><K><A><F><I><K><K><S><H><L><L><R><H><Q><I><T><H><T><G><E><K><P><Y><E><C><N><R><C><G><K><A><F><S><Q><K><S><N><L><I><V><H><Q><K><I><H><T> | May be involved in transcriptional regulation.<BOP> | Q5T5D7 |
Q03426 | KIME_HUMAN | Mevalonate kinase | Homo | <M><L><S><E><V><L><L><V><S><A><P><G><K><V><I><L><H><G><E><H><A><V><V><H><G><K><V><A><L><A><V><S><L><N><L><R><T><F><L><R><L><Q><P><H><S><N><G><K><V><D><L><S><L><P><N><I><G><I><K><R><A><W><D><V><A><R><L><Q><S><L><D><T><S><F><L><E><Q><G><D><V><T><T><P><T><S><E><Q><V><E><K><L><K><E><V><A><G><L><P><D><D><C><A><V><T><E><R><L><A><V><L><A><F><L><Y><L><Y><L><S><I><C><R><K><Q><R><A><L><P><S><L><D><I><V><V><W><S><E><L><P><P><G><A><G><L><G><S><S><A><A><Y><S><V><C><L><A><A><A><L><L><T><V><C><E><E><I><P><N><P><L><K><D><G><D><C><V><N><R><W><T><K><E><D><L><E><L><I><N><K><W><A><F><Q><G><E><R><M><I><H><G><N><P><S><G><V><D><N><A><V><S><T><W><G><G><A><L><R><Y><H><Q><G><K><I><S><S><L><K><R><S><P><A><L><Q><I><L><L><T><N><T><K><V><P><R><N><T><R><A><L><V><A><G><V><R><N><R><L><L><K><F><P><E><I><V><A><P><L><L><T><S><I><D><A><I><S><L><E><C><E><R><V><L><G><E><M><G><E><A><P><A><P><E><Q><Y><L><V><L><E><E><L><I><D><M><N><Q><H><H><L><N><A><L><G><V><G><H><A><S><L><D><Q><L><C><Q><V><T><R><A><R><G><L><H><S><K><L><T><G><A><G><G><G><G><C><G><I><T><L><L><K><P><G><L><E><Q><P><E><V><E><A><T><K><Q><A><L><T><S><C><G><F><D><C><L><E><T><S><I><G><A><P><G><V><S><I><H><S><A><T><S><L><D><S><R><V><Q><Q><A><L><D><G><L> | Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis .<BOP> | Q03426 |
P31512 | FMO4_HUMAN | Hepatic flavin-containing monooxygenase 4 | Homo | <M><A><K><K><V><A><V><I><G><A><G><V><S><G><L><S><S><I><K><C><C><V><D><E><D><L><E><P><T><C><F><E><R><S><D><D><I><G><G><L><W><K><F><T><E><S><S><K><D><G><M><T><R><V><Y><K><S><L><V><T><N><V><C><K><E><M><S><C><Y><S><D><F><P><F><H><E><D><Y><P><N><F><M><N><H><E><K><F><W><D><Y><L><Q><E><F><A><E><H><F><D><L><L><K><Y><I><Q><F><K><T><T><V><C><S><I><T><K><R><P><D><F><S><E><T><G><Q><W><D><V><V><T><E><T><E><G><K><Q><N><R><A><V><F><D><A><V><M><V><C><T><G><H><F><L><N><P><H><L><P><L><E><A><F><P><G><I><H><K><F><K><G><Q><I><L><H><S><Q><E><Y><K><I><P><E><G><F><Q><G><K><R><V><L><V><I><G><L><G><N><T><G><G><D><I><A><V><E><L><S><R><T><A><A><Q><V><L><L><S><T><R><T><G><T><W><V><L><G><R><S><S><D><W><G><Y><P><Y><N><M><M><V><T><R><R><C><C><S><F><I><A><Q><V><L><P><S><R><F><L><N><W><I><Q><E><R><K><L><N><K><R><F><N><H><E><D><Y><G><L><S><I><T><K><G><K><K><A><K><F><I><V><N><D><E><L><P><N><C><I><L><C><G><A><I><T><M><K><T><S><V><I><E><F><T><E><T><S><A><V><F><E><D><G><T><V><E><E><N><I><D><V><V><I><F><T><T><G><Y><T><F><S><F><P><F><F><E><E><P><L><K><S><L><C><T><K><K><I><F><L><Y><K><Q><V><F><P><L><N><L><E><R><A><T><L><A><I><I><G><L><I><G><L><K><G><S><I><L><S><G><T><E><L><Q><A><R><W><V><T><R><V><F><K><G><L><C><K><I><P><P><S><Q><K><L><M><M><E><A><T><E><K><E><Q><L><I><K><R><G><V><F><K><D><T><S><K><D><K><F><D><Y><I><A><Y><M><D><D><I><A><A><C><I><G><T><K><P><S><I><P><L><L><F><L><K><D><P><R><L><A><W><E><V><F><F><G><P><C><T><P><Y><Q><Y><R><L><M><G><P><G><K><W><D><G><A><R><N><A><I><L><T><Q><W><D><R><T><L><K><P><L><K><T><R><I><V><P><D><S><S><K><P><A><S><M><S><H><Y><L><K><A><W><G><A><P><V><L><L><A><S><L><L><L><I><C><K><S><S><L><F><L><K><L><V><R><D><K><L><Q><D><R><M><S><P><Y><L><V><S><L><W><R><G> | This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.<BOP> | P31512 |
Q9NUL5 | SHFL_HUMAN | Repressor of yield of DENV protein | Homo | <M><S><Q><E><G><V><E><L><E><K><S><V><R><R><L><R><E><K><F><H><G><K><V><S><S><K><K><A><G><A><L><M><R><K><F><G><S><D><H><T><G><V><G><R><S><I><V><Y><G><V><K><Q><K><D><G><Q><E><L><S><N><D><L><D><A><Q><D><P><P><E><D><M><K><Q><D><R><D><I><Q><A><V><A><T><S><L><L><P><L><T><E><A><N><L><R><M><F><Q><R><A><Q><D><D><L><I><P><A><V><D><R><Q><F><A><C><S><S><C><D><H><V><W><W><R><R><V><P><Q><R><K><E><V><S><R><C><R><K><C><R><K><R><Y><E><P><V><P><A><D><K><M><W><G><L><A><E><F><H><C><P><K><C><R><H><N><F><R><G><W><A><Q><M><G><S><P><S><P><C><Y><G><C><G><F><P><V><Y><P><T><R><I><L><P><P><R><W><D><R><D><P><D><R><R><S><T><H><T><H><S><C><S><A><A><D><C><Y><N><R><R><E><P><H><V><P><G><T><S><C><A><H><P><K><S><R><K><Q><N><H><L><P><K><V><L><H><P><S><N><P><H><I><S><S><G><S><T><V><A><T><C><L><S><Q><G><G><L><L><E><D><L><D><N><L><I><L><E><D><L><K><E><E><E><E><E><E><E><E><V><E><D><E><E><G><G><P><R><E> | Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes.<BOP> | Q9NUL5 |
Q96R48 | OR2A5_HUMAN | Olfactory receptor 7-138/7-141 | Homo | <M><T><K><N><Q><T><W><V><T><E><F><I><L><L><G><F><P><L><S><L><R><I><Q><M><L><L><S><G><L><F><S><L><L><Y><V><F><T><L><L><G><N><G><A><I><L><G><L><I><W><L><D><S><R><L><H><T><P><M><Y><F><F><L><S><H><L><A><I><I><D><I><S><Y><A><S><N><N><V><P><K><M><L><T><N><L><G><L><N><K><R><K><T><I><S><F><V><P><C><T><M><Q><T><F><L><Y><M><A><F><A><H><T><E><C><L><I><L><V><M><M><S><Y><D><R><Y><M><A><I><C><H><P><L><Q><Y><S><V><I><M><R><W><G><V><C><T><V><L><A><V><T><S><W><A><C><G><S><L><L><A><L><V><H><V><V><L><I><L><R><L><P><F><C><G><P><H><E><I><N><H><F><F><C><E><I><L><S><V><L><K><L><A><C><A><D><T><W><L><N><Q><V><V><I><F><A><A><S><V><F><I><L><V><G><P><L><C><L><V><L><V><S><Y><S><R><I><L><A><A><I><L><R><I><Q><S><G><E><G><R><R><K><A><F><S><T><C><S><S><H><L><C><M><V><G><L><F><F><G><S><A><I><V><M><Y><M><A><P><K><S><R><H><P><E><E><Q><Q><K><V><L><S><L><F><Y><S><L><F><N><P><M><L><N><P><L><I><Y><S><L><R><N><A><E><V><K><G><A><L><K><R><V><L><W><K><Q><R><S><K> | Odorant receptor.<BOP> | Q96R48 |
Q99748 | NRTN_HUMAN | Neurturin | Homo | <M><Q><R><W><K><A><A><A><L><A><S><V><L><C><S><S><V><L><S><I><W><M><C><R><E><G><L><L><L><S><H><R><L><G><P><A><L><V><P><L><H><R><L><P><R><T><L><D><A><R><I><A><R><L><A><Q><Y><R><A><L><L><Q><G><A><P><D><A><M><E><L><R><E><L><T><P><W><A><G><R><P><P><G><P><R><R><R><A><G><P><R><R><R><R><A><R><A><R><L><G><A><R><P><C><G><L><R><E><L><E><V><R><V><S><E><L><G><L><G><Y><A><S><D><E><T><V><L><F><R><Y><C><A><G><A><C><E><A><A><A><R><V><Y><D><L><G><L><R><R><L><R><Q><R><R><R><L><R><R><E><R><V><R><A><Q><P><C><C><R><P><T><A><Y><E><D><E><V><S><F><L><D><A><H><S><R><Y><H><T><V><H><E><L><S><A><R><E><C><A><C><V> | Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.<BOP> | Q99748 |
P20815 | CP3A5_HUMAN | Cytochrome P450-PCN3 | Homo | <M><D><L><I><P><N><L><A><V><E><T><W><L><L><L><A><V><S><L><V><L><L><Y><L><Y><G><T><R><T><H><G><L><F><K><R><L><G><I><P><G><P><T><P><L><P><L><L><G><N><V><L><S><Y><R><Q><G><L><W><K><F><D><T><E><C><Y><K><K><Y><G><K><M><W><G><T><Y><E><G><Q><L><P><V><L><A><I><T><D><P><D><V><I><R><T><V><L><V><K><E><C><Y><S><V><F><T><N><R><R><S><L><G><P><V><G><F><M><K><S><A><I><S><L><A><E><D><E><E><W><K><R><I><R><S><L><L><S><P><T><F><T><S><G><K><L><K><E><M><F><P><I><I><A><Q><Y><G><D><V><L><V><R><N><L><R><R><E><A><E><K><G><K><P><V><T><L><K><D><I><F><G><A><Y><S><M><D><V><I><T><G><T><S><F><G><V><N><I><D><S><L><N><N><P><Q><D><P><F><V><E><S><T><K><K><F><L><K><F><G><F><L><D><P><L><F><L><S><I><I><L><F><P><F><L><T><P><V><F><E><A><L><N><V><S><L><F><P><K><D><T><I><N><F><L><S><K><S><V><N><R><M><K><K><S><R><L><N><D><K><Q><K><H><R><L><D><F><L><Q><L><M><I><D><S><Q><N><S><K><E><T><E><S><H><K><A><L><S><D><L><E><L><A><A><Q><S><I><I><F><I><F><A><G><Y><E><T><T><S><S><V><L><S><F><T><L><Y><E><L><A><T><H><P><D><V><Q><Q><K><L><Q><K><E><I><D><A><V><L><P><N><K><A><P><P><T><Y><D><A><V><V><Q><M><E><Y><L><D><M><V><V><N><E><T><L><R><L><F><P><V><A><I><R><L><E><R><T><C><K><K><D><V><E><I><N><G><V><F><I><P><K><G><S><M><V><V><I><P><T><Y><A><L><H><H><D><P><K><Y><W><T><E><P><E><E><F><R><P><E><R><F><S><K><K><K><D><S><I><D><P><Y><I><Y><T><P><F><G><T><G><P><R><N><C><I><G><M><R><F><A><L><M><N><M><K><L><A><L><I><R><V><L><Q><N><F><S><F><K><P><C><K><E><T><Q><I><P><L><K><L><D><T><Q><G><L><L><Q><P><E><K><P><I><V><L><K><V><D><S><R><D><G><T><L><S><G><E> | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds . Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 . Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione . Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) . Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance . Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifed | P20815 |
P08218 | CEL2B_HUMAN | Elastase-2B | Homo | <M><I><R><T><L><L><L><S><T><L><V><A><G><A><L><S><C><G><V><S><T><Y><A><P><D><M><S><R><M><L><G><G><E><E><A><R><P><N><S><W><P><W><Q><V><S><L><Q><Y><S><S><N><G><Q><W><Y><H><T><C><G><G><S><L><I><A><N><S><W><V><L><T><A><A><H><C><I><S><S><S><G><I><Y><R><V><M><L><G><Q><H><N><L><Y><V><A><E><S><G><S><L><A><V><S><V><S><K><I><V><V><H><K><D><W><N><S><D><Q><V><S><K><G><N><D><I><A><L><L><K><L><A><N><P><V><S><L><T><D><K><I><Q><L><A><C><L><P><P><A><G><T><I><L><P><N><N><Y><P><C><Y><V><T><G><W><G><R><L><Q><T><N><G><A><L><P><D><D><L><K><Q><G><Q><L><L><V><V><D><Y><A><T><C><S><S><S><G><W><W><G><S><T><V><K><T><N><M><I><C><A><G><G><D><G><V><I><C><T><C><N><G><D><S><G><G><P><L><N><C><Q><A><S><D><G><R><W><E><V><H><G><I><G><S><L><T><S><V><L><G><C><N><Y><Y><Y><K><P><S><I><F><T><R><V><S><N><Y><N><D><W><I><N><S><V><I><A><N><N> | Acts upon elastin.<BOP> | P08218 |
Q14929 | ZN169_HUMAN | Zinc finger protein 169 | Homo | <M><S><P><G><L><L><T><T><R><K><E><A><L><M><A><F><R><D><V><A><V><A><F><T><Q><K><E><W><K><L><L><S><S><A><Q><R><T><L><Y><R><E><V><M><L><E><N><Y><S><H><L><V><S><L><G><I><A><F><S><K><P><K><L><I><E><Q><L><E><Q><G><D><E><P><W><R><E><E><N><E><H><L><L><D><L><C><P><E><P><R><T><E><F><Q><P><S><F><P><H><L><V><A><F><S><S><S><Q><L><L><R><Q><Y><A><L><S><G><H><P><T><Q><I><F><P><S><S><S><A><G><G><D><F><Q><L><E><A><P><R><C><S><S><E><K><G><E><S><G><E><T><E><G><P><D><S><S><L><R><K><R><P><S><R><I><S><R><T><F><F><S><P><H><Q><G><D><P><V><E><W><V><E><G><N><R><E><G><G><T><D><L><R><L><A><Q><R><M><S><L><G><G><S><D><T><M><L><K><G><A><D><T><S><E><S><G><A><V><I><R><G><N><Y><R><L><G><L><S><K><K><S><S><L><F><S><H><Q><K><H><H><V><C><P><E><C><G><R><G><F><C><Q><R><S><D><L><I><K><H><Q><R><T><H><T><G><E><K><P><Y><L><C><P><E><C><G><R><R><F><S><Q><K><A><S><L><S><I><H><Q><R><K><H><S><G><E><K><P><Y><V><C><R><E><C><G><R><H><F><R><Y><T><S><S><L><T><N><H><K><R><I><H><S><G><E><R><P><F><V><C><Q><E><C><G><R><G><F><R><Q><K><I><A><L><L><L><H><Q><R><T><H><L><E><E><K><P><F><V><C><P><E><C><G><R><G><F><C><Q><K><A><S><L><L><Q><H><Q><S><S><H><T><G><E><R><P><F><L><C><L><E><C><G><R><S><F><R><Q><Q><S><L><L><L><S><H><Q><V><T><H><S><G><E><K><P><Y><V><C><A><E><C><G><H><S><F><R><Q><K><V><T><L><I><R><H><Q><R><T><H><T><G><E><K><P><Y><L><C><P><Q><C><G><R><G><F><S><Q><K><V><T><L><I><G><H><Q><R><T><H><T><G><E><K><P><Y><L><C><P><D><C><G><R><G><F><G><Q><K><V><T><L><I><R><H><Q><R><T><H><T><G><E><K><P><Y><L><C><P><K><C><G><R><A><F><G><F><K><S><L><L><T><R><H><Q><R><T><H><S><E><E><E><L><Y><V><D><R><V><C><G><Q><G><L><G><Q><K><S><H><L><I><S><D><Q><R><T><H><S><G><E><K><P><C><I><C><D><E><C><G><R><G><F><G><F><K><S><A><L><I><R><H><Q><R><T><H><S><G><E><K><P><Y><V><C><R><E><C><G><R><G><F><S><Q><K><S><H><L><H><R><H><R><R><T><K><S><G><H><Q><L><L><P><Q><E><V><F> | May be involved in transcriptional regulation.<BOP> | Q14929 |
Q8NBT0 | POC1A_HUMAN | WD repeat-containing protein 51A | Homo | <M><A><A><P><C><A><E><D><P><S><L><E><R><H><F><K><G><H><R><D><A><V><T><C><V><D><F><S><I><N><T><K><Q><L><A><S><G><S><M><D><S><C><L><M><V><W><H><M><K><P><Q><S><R><A><Y><R><F><T><G><H><K><D><A><V><T><C><V><N><F><S><P><S><G><H><L><L><A><S><G><S><R><D><K><T><V><R><I><W><V><P><N><V><K><G><E><S><T><V><F><R><A><H><T><A><T><V><R><S><V><H><F><C><S><D><G><Q><S><F><V><T><A><S><D><D><K><T><V><K><V><W><A><T><H><R><Q><K><F><L><F><S><L><S><Q><H><I><N><W><V><R><C><A><K><F><S><P><D><G><R><L><I><V><S><A><S><D><D><K><T><V><K><L><W><D><K><S><S><R><E><C><V><H><S><Y><C><E><H><G><G><F><V><T><Y><V><D><F><H><P><S><G><T><C><I><A><A><A><G><M><D><N><T><V><K><V><W><D><V><R><T><H><R><L><L><Q><H><Y><Q><L><H><S><A><A><V><N><G><L><S><F><H><P><S><G><N><Y><L><I><T><A><S><S><D><S><T><L><K><I><L><D><L><M><E><G><R><L><L><Y><T><L><H><G><H><Q><G><P><A><T><T><V><A><F><S><R><T><G><E><Y><F><A><S><G><G><S><D><E><Q><V><M><V><W><K><S><N><F><D><I><V><D><H><G><E><V><T><K><V><P><R><P><P><A><T><L><A><S><S><M><G><N><L><P><E><V><D><F><P><V><P><P><G><R><G><R><S><V><E><S><V><Q><S><Q><P><Q><E><P><V><S><V><P><Q><T><L><T><S><T><L><E><H><I><V><G><Q><L><D><V><L><T><Q><T><V><S><I><L><E><Q><R><L><T><L><T><E><D><K><L><K><Q><C><L><E><N><Q><Q><L><I><M><Q><R><A><T><P> | Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.<BOP> | Q8NBT0 |
Q86XU0 | ZN677_HUMAN | Zinc finger protein 677 | Homo | <M><A><L><S><Q><G><L><F><T><F><K><D><V><A><I><E><F><S><Q><E><E><W><E><C><L><D><P><A><Q><R><A><L><Y><R><D><V><M><L><E><N><Y><R><N><L><L><S><L><D><E><D><N><I><P><P><E><D><D><I><S><V><G><F><T><S><K><G><L><S><P><K><E><N><N><K><E><E><L><Y><H><L><V><I><L><E><R><K><E><S><H><G><I><N><N><F><D><L><K><E><V><W><E><N><M><P><K><F><D><S><L><W><D><Y><D><V><K><N><Y><K><G><M><P><L><T><C><N><K><N><L><T><H><R><K><D><Q><Q><H><N><K><S><S><I><H><F><S><L><K><Q><S><V><S><I><R><D><S><A><H><Q><Y><F><I><H><D><K><P><F><I><R><N><L><L><K><L><K><N><N><I><R><Y><A><G><N><K><Y><V><K><C><F><E><N><K><I><G><L><S><L><Q><A><Q><L><A><E><L><Q><R><F><Q><T><G><E><K><M><Y><E><C><N><P><V><E><K><S><I><N><S><S><S><V><S><P><L><P><P><C><V><K><N><I><C><N><K><Y><R><K><I><L><K><Y><P><L><L><H><T><Q><Y><G><R><T><H><I><R><E><K><S><Y><K><C><N><D><C><G><K><A><F><S><K><S><S><N><L><T><N><H><Q><R><I><H><S><G><Q><R><P><Y><K><C><N><E><C><G><K><A><F><N><Q><C><S><N><L><T><R><H><Q><R><V><H><T><G><E><K><P><Y><Q><C><N><I><C><G><K><V><C><S><Q><N><S><N><L><A><S><H><Q><R><M><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><I><Q><R><S><H><L><W><G><H><E><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><D><K><A><F><A><E><R><S><S><L><T><Q><H><K><R><I><H><T><G><E><K><P><Y><I><C><N><E><C><G><K><A><F><K><Q><C><S><H><L><T><R><H><Q><N><I><H><P><G><E><K><P><H><K><C><N><V><C><G><R><A><F><I><Q><S><S><S><L><V><E><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><K><C><D><K><A><F><I><K><R><S><H><L><W><G><H><Q><R><T><H><T><G><E><K><P><Y><K><C><T><E><C><G><K><A><F><T><E><R><S><N><L><T><Q><H><K><K><I><H><T><G><E><K><P><Y><K><C><T><E><C><G><K><A><F><T><Q><F><A><N><L><T><R><H><Q><K><I><H><I><E><K><K><H><C><K><H><N><I><H><G><N><A><L><F><Q><S><S><N><L><G><D><H><Q><K><S><Y><N><R><E><K><H><I><K><Y><N><E><T><K><I><K><Y><S><S><C><T> | May be involved in transcriptional regulation.<BOP> | Q86XU0 |
Q01344 | IL5RA_HUMAN | CDw125 | Homo | <M><I><I><V><A><H><V><L><L><I><L><L><G><A><T><E><I><L><Q><A><D><L><L><P><D><E><K><I><S><L><L><P><P><V><N><F><T><I><K><V><T><G><L><A><Q><V><L><L><Q><W><K><P><N><P><D><Q><E><Q><R><N><V><N><L><E><Y><Q><V><K><I><N><A><P><K><E><D><D><Y><E><T><R><I><T><E><S><K><C><V><T><I><L><H><K><G><F><S><A><S><V><R><T><I><L><Q><N><D><H><S><L><L><A><S><S><W><A><S><A><E><L><H><A><P><P><G><S><P><G><T><S><I><V><N><L><T><C><T><T><N><T><T><E><D><N><Y><S><R><L><R><S><Y><Q><V><S><L><H><C><T><W><L><V><G><T><D><A><P><E><D><T><Q><Y><F><L><Y><Y><R><Y><G><S><W><T><E><E><C><Q><E><Y><S><K><D><T><L><G><R><N><I><A><C><W><F><P><R><T><F><I><L><S><K><G><R><D><W><L><A><V><L><V><N><G><S><S><K><H><S><A><I><R><P><F><D><Q><L><F><A><L><H><A><I><D><Q><I><N><P><P><L><N><V><T><A><E><I><E><G><T><R><L><S><I><Q><W><E><K><P><V><S><A><F><P><I><H><C><F><D><Y><E><V><K><I><H><N><T><R><N><G><Y><L><Q><I><E><K><L><M><T><N><A><F><I><S><I><I><D><D><L><S><K><Y><D><V><Q><V><R><A><A><V><S><S><M><C><R><E><A><G><L><W><S><E><W><S><Q><P><I><Y><V><G><N><D><E><H><K><P><L><R><E><W><F><V><I><V><I><M><A><T><I><C><F><I><L><L><I><L><S><L><I><C><K><I><C><H><L><W><I><K><L><F><P><P><I><P><A><P><K><S><N><I><K><D><L><F><V><T><T><N><Y><E><K><A><G><S><S><E><T><E><I><E><V><I><C><Y><I><E><K><P><G><V><E><T><L><E><D><S><V><F> | Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils . Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5 . In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway .<BOP> | Q01344 |
Q13561 | DCTN2_HUMAN | p50 dynamitin | Homo | <M><A><D><P><K><Y><A><D><L><P><G><I><A><R><N><E><P><D><V><Y><E><T><S><D><L><P><E><D><D><Q><A><E><F><D><A><E><E><L><T><S><T><S><V><E><H><I><I><V><N><P><N><A><A><Y><D><K><F><K><D><K><R><V><G><T><K><G><L><D><F><S><D><R><I><G><K><T><K><R><T><G><Y><E><S><G><E><Y><E><M><L><G><E><G><L><G><V><K><E><T><P><Q><Q><K><Y><Q><R><L><L><H><E><V><Q><E><L><T><T><E><V><E><K><I><K><T><T><V><K><E><S><A><T><E><E><K><L><T><P><V><L><L><A><K><Q><L><A><A><L><K><Q><Q><L><V><A><S><H><L><E><K><L><L><G><P><D><A><A><I><N><L><T><D><P><D><G><A><L><A><K><R><L><L><L><Q><L><E><A><T><K><N><S><K><G><G><S><G><G><K><T><T><G><T><P><P><D><S><S><L><V><T><Y><E><L><H><S><R><P><E><Q><D><K><F><S><Q><A><A><K><V><A><E><L><E><K><R><L><T><E><L><E><T><A><V><R><C><D><Q><D><A><Q><N><P><L><S><A><G><L><Q><G><A><C><L><M><E><T><V><E><L><L><Q><A><K><V><S><A><L><D><L><A><V><L><D><Q><V><E><A><R><L><Q><S><V><L><G><K><V><N><E><I><A><K><H><K><A><S><V><E><D><A><D><T><Q><S><K><V><H><Q><L><Y><E><T><I><Q><R><W><S><P><I><A><S><T><L><P><E><L><V><Q><R><L><V><T><I><K><Q><L><H><E><Q><A><M><Q><F><G><Q><L><L><T><H><L><D><T><T><Q><Q><M><I><A><N><S><L><K><D><N><T><T><L><L><T><Q><V><Q><T><T><M><R><E><N><L><A><T><V><E><G><N><F><A><S><I><D><E><R><M><K><K><L><G><K> | Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.<BOP> | Q13561 |
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