accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q92599
SEPT8_HUMAN
Septin-8
Homo
<M><A><A><T><D><L><E><R><F><S><N><A><E><P><E><P><R><S><L><S><L><G><G><H><V><G><F><D><S><L><P><D><Q><L><V><S><K><S><V><T><Q><G><F><S><F><N><I><L><C><V><G><E><T><G><I><G><K><S><T><L><M><N><T><L><F><N><T><T><F><E><T><E><E><A><S><H><H><E><A><C><V><R><L><R><P><Q><T><Y><D><L><Q><E><S><N><V><Q><L><K><L><T><I><V><D><A><V><G><F><G><D><Q><I><N><K><D><E><S><Y><R><P><I><V><D><Y><I><D><A><Q><F><E><N><Y><L><Q><E><E><L><K><I><R><R><S><L><F><D><Y><H><D><T><R><I><H><V><C><L><Y><F><I><T><P><T><G><H><S><L><K><S><L><D><L><V><T><M><K><K><L><D><S><K><V><N><I><I><P><I><I><A><K><A><D><T><I><S><K><S><E><L><H><K><F><K><I><K><I><M><G><E><L><V><S><N><G><V><Q><I><Y><Q><F><P><T><D><D><E><A><V><A><E><I><N><A><V><M><N><A><H><L><P><F><A><V><V><G><S><T><E><E><V><K><V><G><N><K><L><V><R><A><R><Q><Y><P><W><G><V><V><Q><V><E><N><E><N><H><C><D><F><V><K><L><R><E><M><L><I><R><V><N><M><E><D><L><R><E><Q><T><H><S><R><H><Y><E><L><Y><R><R><C><K><L><E><E><M><G><F><Q><D><S><D><G><D><S><Q><P><F><S><L><Q><E><T><Y><E><A><K><R><K><E><F><L><S><E><L><Q><R><K><E><E><E><M><R><Q><M><F><V><N><K><V><K><E><T><E><L><E><L><K><E><K><E><R><E><L><H><E><K><F><E><H><L><K><R><V><H><Q><E><E><K><R><K><V><E><E><K><R><R><E><L><E><E><E><T><N><A><F><N><R><R><K><A><A><V><E><A><L><Q><S><Q><A><L><H><A><T><S><Q><Q><P><L><R><K><D><K><D><K><K><N><R><S><D><I><G><A><H><Q><P><G><M><S><L><S><S><S><K><V><M><M><T><K><A><S><V><E><P><L><N><C><S><S><W><W><P><A><I><Q><C><C><S><C><L><V><R><D><A><T><W><R><E><G><F><L>
Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.<BOP>
Q92599
Q9ULJ1
ODF2L_HUMAN
Outer dense fiber protein 2-like
Homo
<M><E><K><A><V><N><D><G><S><H><S><E><E><L><F><C><H><L><K><T><I><S><E><K><E><D><L><P><R><C><T><S><E><S><H><L><S><C><L><K><Q><D><I><L><N><E><K><T><E><L><E><A><T><L><K><E><A><E><L><V><T><H><S><V><E><L><L><L><P><L><F><K><D><T><I><E><K><I><N><F><E><N><A><N><L><S><A><L><N><L><K><I><S><E><Q><K><E><I><L><I><K><E><L><D><T><F><K><S><V><K><L><A><L><E><H><L><L><R><K><R><D><Y><K><Q><T><G><D><N><L><S><S><M><L><L><E><N><L><T><D><N><E><S><E><N><T><N><L><K><K><K><V><F><E><K><E><A><H><I><Q><E><L><S><C><L><F><Q><S><E><K><A><N><T><L><K><A><N><R><F><S><Q><S><V><K><V><V><H><E><R><L><Q><I><Q><I><H><K><R><E><A><E><N><D><K><L><K><E><Y><V><K><S><L><E><T><K><I><A><K><W><N><L><Q><S><R><M><N><K><N><E><A><I><V><M><K><E><A><S><R><Q><K><T><V><A><L><K><K><A><S><K><V><Y><K><Q><R><L><D><H><F><T><G><A><I><E><K><L><T><S><Q><I><R><D><Q><E><A><K><L><S><E><T><I><S><A><S><N><A><W><K><S><H><Y><E><K><I><V><I><E><K><T><E><L><E><V><Q><I><E><T><M><K><K><Q><I><I><N><L><L><E><D><L><K><K><M><E><D><H><G><K><N><S><C><E><E><I><L><R><K><V><H><S><I><E><Y><E><N><E><T><L><N><L><E><N><T><K><L><K><L><R><F><P><C><R><I><T><E><S><K><N><M><N><I><L><I><V><L><D><M><L><C><Y><I><S><S><E><K><T><T><L><A><A><L><K><D><E><V><V><S><V><E><N><E><L><S><E><L><Q><E><V><E><K><K><Q><K><T><L><I><E><M><Y><K><T><Q><V><Q><K><L><Q><E><A><A><E><I><V><K><S><R><C><E><N><L><L><H><K><N><N><Q><I><T><K><T><K><N><K><N><V><E><K><M><R><G><Q><M><E><S><H><L><K><E><L><E><R><V><C><D><S><L><T><A><A><E><R><R><L><H><E><C><Q><E><S><L><Q><C><C><K><G><K><C><A><D><Q><E><H><T><I><R><E><L><Q><G><Q><V><D><G><N><H><N><L><L><T><K><L><S><L><E><E><E><N><C><L><I><Q><L><K><C><E><N><L><Q><Q><K><L><E><Q><M><D><A><E><N><K><E><L><E><K><K><L><A><N><Q><E><E><C><L><K><H><S><N><L><K><F><K><E><K><S><A><E><Y><T><A><L><A><R><Q><L><E><A><A><L><E><E><G><R><Q><K><V><A><E><E><I><E><K><M><S><S><R><E><S><A><L><Q><I><K><I><L><D><L><E><T><E><L><R><K><K><N><E><E><Q><N><Q><L><V><C><K><M><N><S><D><P><E><T><P>
Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.<BOP>
Q9ULJ1
Q86TN4
TRPT1_HUMAN
tRNA 2'-phosphotransferase 1
Homo
<M><N><F><S><G><G><G><R><Q><E><A><A><G><S><R><G><R><R><A><P><R><P><R><E><Q><D><R><D><V><Q><L><S><K><A><L><S><Y><A><L><R><H><G><A><L><K><L><G><L><P><M><G><A><D><G><F><V><P><L><G><T><L><L><Q><L><P><Q><F><R><G><F><S><A><E><D><V><Q><R><V><V><D><T><N><R><K><Q><R><F><A><L><Q><L><G><D><P><S><T><G><L><L><I><R><A><N><Q><G><H><S><L><Q><V><P><K><L><E><L><M><P><L><E><T><P><Q><A><L><P><P><M><L><V><H><G><T><F><W><K><H><W><P><S><I><L><L><K><G><L><S><C><Q><G><R><T><H><I><H><L><A><P><G><L><P><G><D><P><G><I><I><S><G><M><R><S><H><C><E><I><A><V><F><I><D><G><P><L><A><L><A><D><G><I><P><F><F><R><S><A><N><G><V><I><L><T><P><G><N><T><D><G><F><L><L><P><K><Y><F><K><E><A><L><Q><L><R><P><T><R><K><P><L><S><L><A><G><D><E><E><T><E><C><Q><S><S><P><K><H><S><S><R><E><R><R><R><I><Q><Q>
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.<BOP>
Q86TN4
P25788
PSA3_HUMAN
Proteasome component C8
Homo
<M><S><S><I><G><T><G><Y><D><L><S><A><S><T><F><S><P><D><G><R><V><F><Q><V><E><Y><A><M><K><A><V><E><N><S><S><T><A><I><G><I><R><C><K><D><G><V><V><F><G><V><E><K><L><V><L><S><K><L><Y><E><E><G><S><N><K><R><L><F><N><V><D><R><H><V><G><M><A><V><A><G><L><L><A><D><A><R><S><L><A><D><I><A><R><E><E><A><S><N><F><R><S><N><F><G><Y><N><I><P><L><K><H><L><A><D><R><V><A><M><Y><V><H><A><Y><T><L><Y><S><A><V><R><P><F><G><C><S><F><M><L><G><S><Y><S><V><N><D><G><A><Q><L><Y><M><I><D><P><S><G><V><S><Y><G><Y><W><G><C><A><I><G><K><A><R><Q><A><A><K><T><E><I><E><K><L><Q><M><K><E><M><T><C><R><D><I><V><K><E><V><A><K><I><I><Y><I><V><H><D><E><V><K><D><K><A><F><E><L><E><L><S><W><V><G><E><L><T><N><G><R><H><E><I><V><P><K><D><I><R><E><E><A><E><K><Y><A><K><E><S><L><K><E><E><D><E><S><D><D><D><N><M>
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.<BOP>
P25788
P35348
ADA1A_HUMAN
Alpha-adrenergic receptor 1c
Homo
<M><V><F><L><S><G><N><A><S><D><S><S><N><C><T><Q><P><P><A><P><V><N><I><S><K><A><I><L><L><G><V><I><L><G><G><L><I><L><F><G><V><L><G><N><I><L><V><I><L><S><V><A><C><H><R><H><L><H><S><V><T><H><Y><Y><I><V><N><L><A><V><A><D><L><L><L><T><S><T><V><L><P><F><S><A><I><F><E><V><L><G><Y><W><A><F><G><R><V><F><C><N><I><W><A><A><V><D><V><L><C><C><T><A><S><I><M><G><L><C><I><I><S><I><D><R><Y><I><G><V><S><Y><P><L><R><Y><P><T><I><V><T><Q><R><R><G><L><M><A><L><L><C><V><W><A><L><S><L><V><I><S><I><G><P><L><F><G><W><R><Q><P><A><P><E><D><E><T><I><C><Q><I><N><E><E><P><G><Y><V><L><F><S><A><L><G><S><F><Y><L><P><L><A><I><I><L><V><M><Y><C><R><V><Y><V><V><A><K><R><E><S><R><G><L><K><S><G><L><K><T><D><K><S><D><S><E><Q><V><T><L><R><I><H><R><K><N><A><P><A><G><G><S><G><M><A><S><A><K><T><K><T><H><F><S><V><R><L><L><K><F><S><R><E><K><K><A><A><K><T><L><G><I><V><V><G><C><F><V><L><C><W><L><P><F><F><L><V><M><P><I><G><S><F><F><P><D><F><K><P><S><E><T><V><F><K><I><V><F><W><L><G><Y><L><N><S><C><I><N><P><I><I><Y><P><C><S><S><Q><E><F><K><K><A><F><Q><N><V><L><R><I><Q><C><L><C><R><K><Q><S><S><K><H><A><L><G><Y><T><L><H><P><P><S><Q><A><V><E><G><Q><H><K><D><M><V><R><I><P><V><G><S><R><E><T><F><Y><R><I><S><K><T><D><G><V><C><E><W><K><F><F><S><S><M><P><R><G><S><A><R><I><T><V><S><K><D><Q><S><S><C><T><T><A><R><V><R><S><K><S><F><L><Q><V><C><C><C><V><G><P><S><T><P><S><L><D><K><N><H><Q><V><P><T><I><K><V><H><T><I><S><L><S><E><N><G><E><E><V>
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.<BOP>
P35348
Q6L8G4
KR511_HUMAN
Ultrahigh sulfur keratin-associated protein 5.11
Homo
<M><G><C><C><G><C><S><G><G><C><G><S><G><C><G><G><C><G><S><G><S><G><G><C><G><S><G><C><G><G><C><G><S><S><C><C><V><P><I><C><C><C><K><P><V><C><C><C><V><P><A><C><S><C><S><S><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><S><S><K><G><G><C><G><S><C><G><C><S><Q><S><N><C><C><K><P><C><C><S><S><S><G><C><G><S><F><C><C><Q><S><S><C><S><K><P><C><C><C><Q><S><S><C><C><Q><S><S><C><C><K><P><C><C><C><Q><S><S><C><C><Q><S><S><C><F><K><P><C><C><C><Q><S><S><C><C><V><P><V><C><C><Q><C><K><I>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q6L8G4
Q9HBF5
ST20_HUMAN
Human cervical cancer suppressor gene 1 protein
Homo
<M><A><R><S><R><L><T><A><T><S><V><S><Q><V><Q><E><N><G><F><V><K><K><L><E><P><K><S><G><W><M><T><F><L><E><V><T><G><K><I><C><E><M><L><F><C><P><E><A><I><L><L><T><R><K><D><T><P><Y><C><E><T><G><L><I><F><L><T><L><T><K><T><I><A><N><T><Y><F><Y><F>
May act as a tumor suppressor. Promotes apoptosis of cancer cells.<BOP>
Q9HBF5
P51159
RB27A_HUMAN
GTP-binding protein Ram
Homo
<M><S><D><G><D><Y><D><Y><L><I><K><F><L><A><L><G><D><S><G><V><G><K><T><S><V><L><Y><Q><Y><T><D><G><K><F><N><S><K><F><I><T><T><V><G><I><D><F><R><E><K><R><V><V><Y><R><A><S><G><P><D><G><A><T><G><R><G><Q><R><I><H><L><Q><L><W><D><T><A><G><Q><E><R><F><R><S><L><T><T><A><F><F><R><D><A><M><G><F><L><L><L><F><D><L><T><N><E><Q><S><F><L><N><V><R><N><W><I><S><Q><L><Q><M><H><A><Y><C><E><N><P><D><I><V><L><C><G><N><K><S><D><L><E><D><Q><R><V><V><K><E><E><E><A><I><A><L><A><E><K><Y><G><I><P><Y><F><E><T><S><A><A><N><G><T><N><I><S><Q><A><I><E><M><L><L><D><L><I><M><K><R><M><E><R><C><V><D><K><S><W><I><P><E><G><V><V><R><S><N><G><H><A><S><T><D><Q><L><S><E><E><K><E><K><G><A><C><G><C>
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion . Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.<BOP>
P51159
Q86V35
CABP7_HUMAN
Calneuron-2
Homo
<M><P><F><H><P><V><T><A><A><L><M><Y><R><G><I><Y><T><V><P><N><L><L><S><E><Q><R><P><V><D><I><P><E><D><E><L><E><E><I><R><E><A><F><K><V><F><D><R><D><G><N><G><F><I><S><K><Q><E><L><G><T><A><M><R><S><L><G><Y><M><P><N><E><V><E><L><E><V><I><I><Q><R><L><D><M><D><G><D><G><Q><V><D><F><E><E><F><V><T><L><L><G><P><K><L><S><T><S><G><I><P><E><K><F><H><G><T><D><F><D><T><V><F><W><K><C><D><M><Q><K><L><T><V><D><E><L><K><R><L><L><Y><D><T><F><C><E><H><L><S><M><K><D><I><E><N><I><I><M><T><E><E><E><S><H><L><G><T><A><E><E><C><P><V><D><V><E><T><C><S><N><Q><Q><I><R><Q><T><C><V><R><K><S><L><I><C><A><F><A><I><A><F><I><I><S><V><M><L><I><A><A><N><Q><V><L><R><S><G><M><K>
Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.<BOP>
Q86V35
P37059
DHB2_HUMAN
Testosterone 17-beta-dehydrogenase
Homo
<M><S><T><F><F><S><D><T><A><W><I><C><L><A><V><P><T><V><L><C><G><T><V><F><C><K><Y><K><K><S><S><G><Q><L><W><S><W><M><V><C><L><A><G><L><C><A><V><C><L><L><I><L><S><P><F><W><G><L><I><L><F><S><V><S><C><F><L><M><Y><T><Y><L><S><G><Q><E><L><L><P><V><D><Q><K><A><V><L><V><T><G><G><D><C><G><L><G><H><A><L><C><K><Y><L><D><E><L><G><F><T><V><F><A><G><V><L><N><E><N><G><P><G><A><E><E><L><R><R><T><C><S><P><R><L><S><V><L><Q><M><D><I><T><K><P><V><Q><I><K><D><A><Y><S><K><V><A><A><M><L><Q><D><R><G><L><W><A><V><I><N><N><A><G><V><L><G><F><P><T><D><G><E><L><L><L><M><T><D><Y><K><Q><C><M><A><V><N><F><F><G><T><V><E><V><T><K><T><F><L><P><L><L><R><K><S><K><G><R><L><V><N><V><S><S><M><G><G><G><A><P><M><E><R><L><A><S><Y><G><S><S><K><A><A><V><T><M><F><S><S><V><M><R><L><E><L><S><K><W><G><I><K><V><A><S><I><Q><P><G><G><F><L><T><N><I><A><G><T><S><D><K><W><E><K><L><E><K><D><I><L><D><H><L><P><A><E><V><Q><E><D><Y><G><Q><D><Y><I><L><A><Q><R><N><F><L><L><L><I><N><S><L><A><S><K><D><F><S><P><V><L><R><D><I><Q><H><A><I><L><A><K><S><P><F><A><Y><Y><T><P><G><K><G><A><Y><L><W><I><C><L><A><H><Y><L><P><I><G><I><Y><D><Y><F><A><K><R><H><F><G><Q><D><K><P><M><P><R><A><L><R><M><P><N><Y><K><K><K><A><T>
Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity.<BOP>
P37059
P43308
SSRB_HUMAN
Signal sequence receptor subunit beta
Homo
<M><R><L><L><S><F><V><V><L><A><L><F><A><V><T><Q><A><E><E><G><A><R><L><L><A><S><K><S><L><L><N><R><Y><A><V><E><G><R><D><L><T><L><Q><Y><N><I><Y><N><V><G><S><S><A><A><L><D><V><E><L><S><D><D><S><F><P><P><E><D><F><G><I><V><S><G><M><L><N><V><K><W><D><R><I><A><P><A><S><N><V><S><H><T><V><V><L><R><P><L><K><A><G><Y><F><N><F><T><S><A><T><I><T><Y><L><A><Q><E><D><G><P><V><V><I><G><S><T><S><A><P><G><Q><G><G><I><L><A><Q><R><E><F><D><R><R><F><S><P><H><F><L><D><W><A><A><F><G><V><M><T><L><P><S><I><G><I><P><L><L><L><W><Y><S><S><K><R><K><Y><D><T><P><K><T><K><K><N>
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.<BOP>
P43308
Q96R28
OR2M2_HUMAN
OST423
Homo
<M><A><W><E><N><Q><T><F><N><S><D><F><I><L><L><G><I><F><N><H><S><P><P><H><T><F><L><F><F><L><V><L><G><I><F><L><V><A><F><M><G><N><S><V><M><V><L><L><I><Y><L><D><T><Q><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><M><D><L><M><L><I><C><T><T><V><P><K><M><A><F><N><Y><L><S><G><S><K><S><I><S><M><A><G><C><V><T><Q><I><F><F><Y><I><S><L><S><G><S><E><C><F><L><L><A><V><M><A><Y><D><R><Y><I><A><I><C><H><P><L><R><Y><T><N><L><M><N><P><K><I><C><G><L><M><A><T><F><S><W><I><L><G><S><T><D><G><I><I><D><A><V><A><T><F><S><F><S><F><C><G><S><R><E><I><A><H><F><F><C><E><F><P><S><L><L><I><L><S><C><N><D><T><S><I><F><E><E><V><I><F><I><C><C><I><V><M><L><V><F><P><V><A><I><I><I><A><S><Y><A><R><V><I><L><A><V><I><H><M><G><S><G><E><G><R><C><K><A><F><T><T><C><S><S><H><L><M><V><V><G><M><Y><Y><G><A><A><L><F><M><Y><I><R><P><T><S><D><H><S><P><T><Q><D><K><M><V><S><V><F><Y><T><I><L><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><V><T><R><A><F><M><K><I><L><G><K><G><K><S><E><S><E><L><P><H><K><L><Y><V><L><L><F><A><K><F><F><F><L><I><S><I><F><F><Y><D><V><K><I><L><A><L><I><M><Y><I><A>
Odorant receptor.<BOP>
Q96R28
Q13541
4EBP1_HUMAN
Phosphorylated heat- and acid-stable protein regulated by insulin 1
Homo
<M><S><G><G><S><S><C><S><Q><T><P><S><R><A><I><P><A><T><R><R><V><V><L><G><D><G><V><Q><L><P><P><G><D><Y><S><T><T><P><G><G><T><L><F><S><T><T><P><G><G><T><R><I><I><Y><D><R><K><F><L><M><E><C><R><N><S><P><V><T><K><T><P><P><R><D><L><P><T><I><P><G><V><T><S><P><S><S><D><E><P><P><M><E><A><S><Q><S><H><L><R><N><S><P><E><D><K><R><A><G><G><E><E><S><Q><F><E><M><D><I>
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<BOP>
Q13541
Q9HD40
SPCS_HUMAN
tRNA(Ser/Sec)-associated antigenic protein
Homo
<M><N><R><E><S><F><A><A><G><E><R><L><V><S><P><A><Y><V><R><Q><G><C><E><A><R><R><S><H><E><H><L><I><R><L><L><L><E><K><G><K><C><P><E><N><G><W><D><E><S><T><L><E><L><F><L><H><E><L><A><I><M><D><S><N><N><F><L><G><N><C><G><V><G><E><R><E><G><R><V><A><S><A><L><V><A><R><R><H><Y><R><F><I><H><G><I><G><R><S><G><D><I><S><A><V><Q><P><K><A><A><G><S><S><L><L><N><K><I><T><N><S><L><V><L><D><I><I><K><L><A><G><V><H><T><V><A><N><C><F><V><V><P><M><A><T><G><M><S><L><T><L><C><F><L><T><L><R><H><K><R><P><K><A><K><Y><I><I><W><P><R><I><D><Q><K><S><C><F><K><S><M><I><T><A><G><F><E><P><V><V><I><E><N><V><L><E><G><D><E><L><R><T><D><L><K><A><V><E><A><K><V><Q><E><L><G><P><D><C><I><L><C><I><H><S><T><T><S><C><F><A><P><R><V><P><D><R><L><E><E><L><A><V><I><C><A><N><Y><D><I><P><H><I><V><N><N><A><Y><G><V><Q><S><S><K><C><M><H><L><I><Q><Q><G><A><R><V><G><R><I><D><A><F><V><Q><S><L><D><K><N><F><M><V><P><V><G><G><A><I><I><A><G><F><N><D><S><F><I><Q><E><I><S><K><M><Y><P><G><R><A><S><A><S><P><S><L><D><V><L><I><T><L><L><S><L><G><S><N><G><Y><K><K><L><L><K><E><R><K><E><M><F><S><Y><L><S><N><Q><I><K><K><L><S><E><A><Y><N><E><R><L><L><H><T><P><H><N><P><I><S><L><A><M><T><L><K><T><L><D><E><H><R><D><K><A><V><T><Q><L><G><S><M><L><F><T><R><Q><V><S><G><A><R><V><V><P><L><G><S><M><Q><T><V><S><G><Y><T><F><R><G><F><M><S><H><T><N><N><Y><P><C><A><Y><L><N><A><A><S><A><I><G><M><K><M><Q><D><V><D><L><F><I><K><R><L><D><R><C><L><K><A><V><R><K><E><R><S><K><E><S><D><D><N><Y><D><K><T><E><D><V><D><I><E><E><M><A><L><K><L><D><N><V><L><L><D><T><Y><Q><D><A><S><S>
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.<BOP>
Q9HD40
Q7L0Q8
RHOU_HUMAN
Wnt-1 responsive Cdc42 homolog 1
Homo
<M><P><P><Q><Q><G><D><P><A><F><P><D><R><C><E><A><P><P><V><P><P><R><R><E><R><G><G><R><G><G><R><G><P><G><E><P><G><G><R><G><R><A><G><G><A><E><G><R><G><V><K><C><V><L><V><G><D><G><A><V><G><K><T><S><L><V><V><S><Y><T><T><N><G><Y><P><T><E><Y><I><P><T><A><F><D><N><F><S><A><V><V><S><V><D><G><R><P><V><R><L><Q><L><C><D><T><A><G><Q><D><E><F><D><K><L><R><P><L><C><Y><T><N><T><D><I><F><L><L><C><F><S><V><V><S><P><S><S><F><Q><N><V><S><E><K><W><V><P><E><I><R><C><H><C><P><K><A><P><I><I><L><V><G><T><Q><S><D><L><R><E><D><V><K><V><L><I><E><L><D><K><C><K><E><K><P><V><P><E><E><A><A><K><L><C><A><E><E><I><K><A><A><S><Y><I><E><C><S><A><L><T><Q><K><N><L><K><E><V><F><D><A><A><I><V><A><G><I><Q><Y><S><D><T><Q><Q><Q><P><K><K><S><K><S><R><T><P><D><K><M><K><N><L><S><K><S><W><W><K><K><Y><C><C><F><V>
Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.<BOP>
Q7L0Q8
Q8IUG1
KRA13_HUMAN
Keratin-associated protein 1.9
Homo
<M><T><C><C><Q><T><S><F><C><G><Y><P><S><C><S><T><S><G><T><C><G><S><S><C><C><Q><P><S><C><C><E><T><S><C><C><Q><P><S><C><C><Q><T><S><F><C><G><F><P><S><F><S><T><S><G><T><C><S><S><S><C><C><Q><P><S><C><C><E><T><S><C><C><Q><P><S><C><C><Q><T><S><S><C><G><T><G><C><G><I><G><G><G><I><G><Y><G><Q><E><G><S><S><G><A><V><S><T><R><I><R><W><C><R><P><D><C><R><V><E><G><T><C><L><P><P><C><C><V><V><S><C><T><P><P><T><C><C><Q><L><H><H><A><E><A><S><C><C><R><P><S><Y><C><G><Q><S><C><C><R><P><V><C><C><C><Y><S><C><E><P><T><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q8IUG1
Q96G79
S35A4_HUMAN
Solute carrier family 35 member A4
Homo
<M><S><V><E><D><G><G><M><P><G><L><G><R><P><R><Q><A><R><W><T><L><M><L><L><L><S><T><A><M><Y><G><A><H><A><P><L><L><A><L><C><H><V><D><G><R><V><P><F><R><P><S><S><A><V><L><L><T><E><L><T><K><L><L><L><C><A><F><S><L><L><V><G><W><Q><A><W><P><Q><G><P><P><P><W><R><Q><A><A><P><F><A><L><S><A><L><L><Y><G><A><N><N><N><L><V><I><Y><L><Q><R><Y><M><D><P><S><T><Y><Q><V><L><S><N><L><K><I><G><S><T><A><V><L><Y><C><L><C><L><R><H><R><L><S><V><R><Q><G><L><A><L><L><L><L><M><A><A><G><A><C><Y><A><A><G><G><L><Q><V><P><G><N><T><L><P><S><P><P><P><A><A><A><A><S><P><M><P><L><H><I><T><P><L><G><L><L><L><L><I><L><Y><C><L><I><S><G><L><S><S><V><Y><T><E><L><L><M><K><R><Q><R><L><P><L><A><L><Q><N><L><F><L><Y><T><F><G><V><L><L><N><L><G><L><H><A><G><G><G><S><G><P><G><L><L><E><G><F><S><G><W><A><A><L><V><V><L><S><Q><A><L><N><G><L><L><M><S><A><V><M><K><H><G><S><S><I><T><R><L><F><V><V><S><C><S><L><V><V><N><A><V><L><S><A><V><L><L><R><L><Q><L><T><A><A><F><F><L><A><T><L><L><I><G><L><A><M><R><L><Y><Y><G><S><R>
Mediates the transport of CDP-ribitol . Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity .<BOP>
Q96G79
Q6ZWK4
RHEX_HUMAN
Regulator of human erythroid cell expansion protein
Homo
<M><L><T><E><V><M><E><V><W><H><G><L><V><I><A><V><V><S><L><F><L><Q><A><C><F><L><T><A><I><N><Y><L><L><S><R><H><M><A><H><K><S><E><Q><I><L><K><A><A><S><L><Q><V><P><R><P><S><P><G><H><H><H><P><P><A><V><K><E><M><K><E><T><Q><T><E><R><D><I><P><M><S><D><S><L><Y><R><H><D><S><D><T><P><S><D><S><L><D><S><S><C><S><S><P><P><A><C><Q><A><T><E><D><V><D><Y><T><Q><V><V><F><S><D><P><G><E><L><K><N><D><S><P><L><D><Y><E><N><I><K><E><I><T><D><Y><V><N><V><N><P><E><R><H><K><P><S><F><W><Y><F><V><N><P><A><L><S><E><P><A><E><Y><D><Q><V><A><M>
Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation .<BOP>
Q6ZWK4
Q9UH92
MLX_HUMAN
Transcription factor-like protein 4
Homo
<M><T><E><P><G><A><S><P><E><D><P><W><V><K><A><S><P><V><G><A><H><A><G><E><G><R><A><G><R><A><R><A><R><R><G><A><G><R><R><G><A><S><L><L><S><P><K><S><P><T><L><S><V><P><R><G><C><R><E><D><S><S><H><P><A><C><A><K><V><E><Y><A><Y><S><D><N><S><L><D><P><G><L><F><V><E><S><T><R><K><G><S><V><V><S><R><A><N><S><I><G><S><T><S><A><S><S><V><P><N><T><D><D><E><D><S><D><Y><H><Q><E><A><Y><K><E><S><Y><K><D><R><R><R><R><A><H><T><Q><A><E><Q><K><R><R><D><A><I><K><R><G><Y><D><D><L><Q><T><I><V><P><T><C><Q><Q><Q><D><F><S><I><G><S><Q><K><L><S><K><A><I><V><L><Q><K><T><I><D><Y><I><Q><F><L><H><K><E><K><K><K><Q><E><E><E><V><S><T><L><R><K><D><V><T><A><L><K><I><M><K><V><N><Y><E><Q><I><V><K><A><H><Q><D><N><P><H><E><G><E><D><Q><V><S><D><Q><V><K><F><N><V><F><Q><G><I><M><D><S><L><F><Q><S><F><N><A><S><I><S><V><A><S><F><Q><E><L><S><A><C><V><F><S><W><I><E><E><H><C><K><P><Q><T><L><R><E><I><V><I><G><V><L><H><Q><L><K><N><Q><L><Y>
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.<BOP>
Q9UH92
Q6NXN4
D19P1_HUMAN
Protein dpy-19 homolog 2-like 1
Homo
<M><K><K><Q><G><V><N><P><K><P><L><Q><S><S><R><P><S><P><S><K><R><P><Y><G><A><S><P><A><R><E><L><E><V><E><K><S><A><L><G><G><G><K><L><P><G><G><A><R><R><S><S><P><G><R><I><P><N><L><K><K><R><K><G><L><E><L><K><V><V><A><K><T><L><L><D><P><F><Q><F><V><R><N><S><L><A><Q><L><R><E><E><V><H><E><L><Q><A><R><W><F><P><S><R><T><T><L><S><I><A><I><F><V><A><I><L><H><W><L><H><L><V><T><L><F><E><N><D><R><H><F><S><H><L><S><S><L><E><W><E><M><T><F><R><T><K><M><G><L><Y><Y><S><Y><F><K><T><I><I><E><A><P><S><F><L><E><G><L><W><M><I><M><N><D><R><L><T><E><Y><P><L><V><I><N><T><V><K><R><F><H><L><Y><P><E><V><I><I><A><A><W><Y><R><T><F><I><G><I><M><N><L><F><G><L><E><T><K><T><C><W><N><V><T><R><I><E><P><L><N><E><F><K><A><V><K><D><W><E><I><L><L><A><F><M><L><V>
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.<BOP>
Q6NXN4
O75326
SEM7A_HUMAN
Semaphorin-L
Homo
<M><T><P><P><P><P><G><R><A><A><P><S><A><P><R><A><R><V><P><G><P><P><A><R><L><G><L><P><L><R><L><R><L><L><L><L><L><W><A><A><A><A><S><A><Q><G><H><L><R><S><G><P><R><I><F><A><V><W><K><G><H><V><G><Q><D><R><V><D><F><G><Q><T><E><P><H><T><V><L><F><H><E><P><G><S><S><S><V><W><V><G><G><R><G><K><V><Y><L><F><D><F><P><E><G><K><N><A><S><V><R><T><V><N><I><G><S><T><K><G><S><C><L><D><K><R><D><C><E><N><Y><I><T><L><L><E><R><R><S><E><G><L><L><A><C><G><T><N><A><R><H><P><S><C><W><N><L><V><N><G><T><V><V><P><L><G><E><M><R><G><Y><A><P><F><S><P><D><E><N><S><L><V><L><F><E><G><D><E><V><Y><S><T><I><R><K><Q><E><Y><N><G><K><I><P><R><F><R><R><I><R><G><E><S><E><L><Y><T><S><D><T><V><M><Q><N><P><Q><F><I><K><A><T><I><V><H><Q><D><Q><A><Y><D><D><K><I><Y><Y><F><F><R><E><D><N><P><D><K><N><P><E><A><P><L><N><V><S><R><V><A><Q><L><C><R><G><D><Q><G><G><E><S><S><L><S><V><S><K><W><N><T><F><L><K><A><M><L><V><C><S><D><A><A><T><N><K><N><F><N><R><L><Q><D><V><F><L><L><P><D><P><S><G><Q><W><R><D><T><R><V><Y><G><V><F><S><N><P><W><N><Y><S><A><V><C><V><Y><S><L><G><D><I><D><K><V><F><R><T><S><S><L><K><G><Y><H><S><S><L><P><N><P><R><P><G><K><C><L><P><D><Q><Q><P><I><P><T><E><T><F><Q><V><A><D><R><H><P><E><V><A><Q><R><V><E><P><M><G><P><L><K><T><P><L><F><H><S><K><Y><H><Y><Q><K><V><A><V><H><R><M><Q><A><S><H><G><E><T><F><H><V><L><Y><L><T><T><D><R><G><T><I><H><K><V><V><E><P><G><E><Q><E><H><S><F><A><F><N><I><M><E><I><Q><P><F><R><R><A><A><A><I><Q><T><M><S><L><D><A><E><R><R><K><L><Y><V><S><S><Q><W><E><V><S><Q><V><P><L><D><L><C><E><V><Y><G><G><G><C><H><G><C><L><M><S><R><D><P><Y><C><G><W><D><Q><G><R><C><I><S><I><Y><S><S><E><R><S><V><L><Q><S><I><N><P><A><E><P><H><K><E><C><P><N><P><K><P><D><K><A><P><L><Q><K><V><S><L><A><P><N><S><R><Y><Y><L><S><C><P><M><E><S><R><H><A><T><Y><S><W><R><H><K><E><N><V><E><Q><S><C><E><P><G><H><Q><S><P><N><C><I><L><F><I><E><N><L><T><A><Q><Q><Y><G><H><Y><F><C><E><A><Q><E><G><S><Y><F><R><E><A><Q><H><W><Q><L><L><P><E><D><G><I><M><A><E><H><L><L><G><H><A><C><A><L><A><A><S><L><W><L><G><V><L><P><T><L><T><L><G><L><L><V><H>
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.<BOP>
O75326
Q9H427
KCNKF_HUMAN
Two pore potassium channel KT3.3
Homo
<M><R><R><P><S><V><R><A><A><G><L><V><L><C><T><L><C><Y><L><L><V><G><A><A><V><F><D><A><L><E><S><E><A><E><S><G><R><Q><R><L><L><V><Q><K><R><G><A><L><R><R><K><F><G><F><S><A><E><D><Y><R><E><L><E><R><L><A><L><Q><A><E><P><H><R><A><G><R><Q><W><K><F><P><G><S><F><Y><F><A><I><T><V><I><T><T><I><E><Y><G><H><A><A><P><G><T><D><S><G><K><V><F><C><M><F><Y><A><L><L><G><I><P><L><T><L><V><T><F><Q><S><L><G><E><R><L><N><A><V><V><R><R><L><L><L><A><A><K><C><C><L><G><L><R><W><T><C><V><S><T><E><N><L><V><V><A><G><L><L><A><C><A><A><T><L><A><L><G><A><V><A><F><S><H><F><E><G><W><T><F><F><H><A><Y><Y><Y><C><F><I><T><L><T><T><I><G><F><G><D><F><V><A><L><Q><S><G><E><A><L><Q><R><K><L><P><Y><V><A><F><S><F><L><Y><I><L><L><G><L><T><V><I><G><A><F><L><N><L><V><V><L><R><F><L><V><A><S><A><D><W><P><E><R><A><A><R><T><P><S><P><R><P><P><G><A><P><E><S><R><G><L><W><L><P><R><R><P><A><R><S><V><G><S><A><S><V><F><C><H><V><H><K><L><E><R><C><A><R><D><N><L><G><F><S><P><P><S><S><P><G><V><V><R><G><G><Q><A><P><R><L><G><A><R><W><K><S><I>
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.<BOP>
Q9H427
Q8IXM2
BAP18_HUMAN
BPTF-associated protein of 18 kDa
Homo
<M><T><S><A><S><T><K><V><G><E><I><F><S><A><A><G><A><A><F><T><K><L><G><E><L><T><M><Q><L><H><P><V><A><D><S><S><P><A><G><A><K><W><T><E><T><E><I><E><M><L><R><A><A><V><K><R><F><G><D><D><L><N><H><I><S><C><V><I><K><E><R><T><V><A><Q><I><K><A><T><V><K><R><K><V><Y><E><D><S><G><I><P><L><P><A><E><S><P><K><K><G><P><K><K><V><A><S><G><V><L><S><P><P><P><A><A><P><P><P><S><S><S><S><V><P><E><A><G><G><P><P><I><K><K><Q><K><A><D><V><T><L><S><A><L><N><D><S><D><A><N><S><D><V><V><D><I><E><G><L><G><E><T><P><P><A><K><K><L><N><F><D><Q><A>
Component of chromatin complexes such as the MLL1/MLL and NURF complexes.<BOP>
Q8IXM2
P15121
ALDR_HUMAN
Aldose reductase
Homo
<M><A><S><R><L><L><L><N><N><G><A><K><M><P><I><L><G><L><G><T><W><K><S><P><P><G><Q><V><T><E><A><V><K><V><A><I><D><V><G><Y><R><H><I><D><C><A><H><V><Y><Q><N><E><N><E><V><G><V><A><I><Q><E><K><L><R><E><Q><V><V><K><R><E><E><L><F><I><V><S><K><L><W><C><T><Y><H><E><K><G><L><V><K><G><A><C><Q><K><T><L><S><D><L><K><L><D><Y><L><D><L><Y><L><I><H><W><P><T><G><F><K><P><G><K><E><F><F><P><L><D><E><S><G><N><V><V><P><S><D><T><N><I><L><D><T><W><A><A><M><E><E><L><V><D><E><G><L><V><K><A><I><G><I><S><N><F><N><H><L><Q><V><E><M><I><L><N><K><P><G><L><K><Y><K><P><A><V><N><Q><I><E><C><H><P><Y><L><T><Q><E><K><L><I><Q><Y><C><Q><S><K><G><I><V><V><T><A><Y><S><P><L><G><S><P><D><R><P><W><A><K><P><E><D><P><S><L><L><E><D><P><R><I><K><A><I><A><A><K><H><N><K><T><T><A><Q><V><L><I><R><F><P><M><Q><R><N><L><V><V><I><P><K><S><V><T><P><E><R><I><A><E><N><F><K><V><F><D><F><E><L><S><S><Q><D><M><T><T><L><L><S><Y><N><R><N><W><R><V><C><A><L><L><S><C><T><S><H><K><D><Y><P><F><H><E><E><F>
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia . Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal . Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides . Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2
P15121
Q9HCU0
CD248_HUMAN
Tumor endothelial marker 1
Homo
<M><L><L><R><L><L><L><A><W><A><A><A><G><P><T><L><G><Q><D><P><W><A><A><E><P><R><A><A><C><G><P><S><S><C><Y><A><L><F><P><R><R><R><T><F><L><E><A><W><R><A><C><R><E><L><G><G><D><L><A><T><P><R><T><P><E><E><A><Q><R><V><D><S><L><V><G><A><G><P><A><S><R><L><L><W><I><G><L><Q><R><Q><A><R><Q><C><Q><L><Q><R><P><L><R><G><F><T><W><T><T><G><D><Q><D><T><A><F><T><N><W><A><Q><P><A><S><G><G><P><C><P><A><Q><R><C><V><A><L><E><A><S><G><E><H><R><W><L><E><G><S><C><T><L><A><V><D><G><Y><L><C><Q><F><G><F><E><G><A><C><P><A><L><Q><D><E><A><G><Q><A><G><P><A><V><Y><T><T><P><F><H><L><V><S><T><E><F><E><W><L><P><F><G><S><V><A><A><V><Q><C><Q><A><G><R><G><A><S><L><L><C><V><K><Q><P><E><G><G><V><G><W><S><R><A><G><P><L><C><L><G><T><G><C><S><P><D><N><G><G><C><E><H><E><C><V><E><E><V><D><G><H><V><S><C><R><C><T><E><G><F><R><L><A><A><D><G><R><S><C><E><D><P><C><A><Q><A><P><C><E><Q><Q><C><E><P><G><G><P><Q><G><Y><S><C><H><C><R><L><G><F><R><P><A><E><D><D><P><H><R><C><V><D><T><D><E><C><Q><I><A><G><V><C><Q><Q><M><C><V><N><Y><V><G><G><F><E><C><Y><C><S><E><G><H><E><L><E><A><D><G><I><S><C><S><P><A><G><A><M><G><A><Q><A><S><Q><D><L><G><D><E><L><L><D><D><G><E><D><E><E><D><E><D><E><A><W><K><A><F><N><G><G><W><T><E><M><P><G><I><L><W><M><E><P><T><Q><P><P><D><F><A><L><A><Y><R><P><S><F><P><E><D><R><E><P><Q><I><P><Y><P><E><P><T><W><P><P><P><L><S><A><P><R><V><P><Y><H><S><S><V><L><S><V><T><R><P><V><V><V><S><A><T><H><P><T><L><P><S><A><H><Q><P><P><V><I><P><A><T><H><P><A><L><S><R><D><H><Q><I><P><V><I><A><A><N><Y><P><D><L><P><S><A><Y><Q><P><G><I><L><S><V><S><H><S><A><Q><P><P><A><H><Q><P><P><M><I><S><T><K><Y><P><E><L><F><P><A><H><Q><S><P><M><F><P><D><T><R><V><A><G><T><Q><T><T><T><H><L><P><G><I><P><P><N><H><A><P><L><V><T><T><L><G><A><Q><L><P><P><Q><A><P><D><A><L><V><L><R><T><Q><A><T><Q><L><P><I><I><P><T><A><Q><P><S><L><T><T><T><S><R><S><P><V><S><P><A><H><Q><I><S><V><P><A><A><T><Q><P><A><A><L><P><T><L><L><P><S><Q><S><P><T><N><Q><T><S><P><I><S><P><T><H><P><H><S><K><A><P><Q><I><P><R><E><D><G><P><S><P><K><L><A><L><W><L><P><S><P><A><P><T><A><A><P><T><A><L><G><E><A><G><L><A><E><H><S><Q><R><D><D><R><W><L><L><V><A><L><L><V><P><T><C><V><F><L><V><V><L><L><A><L><G><I><V><Y><C><T><R><C><G><P><H><A><P><N><K><R><I><T><D><C><Y><R><W><V><I><H><A><G><S><K><S><P><T><E><P><M><P><P><R><G><S><L><T><G><V><Q><T><C><R><T><S><V>
May play a role in tumor angiogenesis.<BOP>
Q9HCU0
A0A2R8Y619
H2BK1_HUMAN
Histone H2B type 2-E1
Homo
<M><S><A><E><Y><G><Q><R><Q><Q><P><G><G><R><G><G><R><S><S><G><N><K><K><S><K><K><R><C><R><R><K><E><S><Y><S><M><Y><I><Y><K><V><L><K><Q><V><H><P><D><I><G><I><S><A><K><A><M><S><I><M><N><S><F><V><N><D><V><F><E><Q><L><A><C><E><A><A><R><L><A><Q><Y><S><G><R><T><T><L><T><S><R><E><V><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><S><K>
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP>
A0A2R8Y619
Q92734
TFG_HUMAN
TRK-fused gene protein
Homo
<M><N><G><Q><L><D><L><S><G><K><L><I><I><K><A><Q><L><G><E><D><I><R><R><I><P><I><H><N><E><D><I><T><Y><D><E><L><V><L><M><M><Q><R><V><F><R><G><K><L><L><S><N><D><E><V><T><I><K><Y><K><D><E><D><G><D><L><I><T><I><F><D><S><S><D><L><S><F><A><I><Q><C><S><R><I><L><K><L><T><L><F><V><N><G><Q><P><R><P><L><E><S><S><Q><V><K><Y><L><R><R><E><L><I><E><L><R><N><K><V><N><R><L><L><D><S><L><E><P><P><G><E><P><G><P><S><T><N><I><P><E><N><D><T><V><D><G><R><E><E><K><S><A><S><D><S><S><G><K><Q><S><T><Q><V><M><A><A><S><M><S><A><F><D><P><L><K><N><Q><D><E><I><N><K><N><V><M><S><A><F><G><L><T><D><D><Q><V><S><G><P><P><S><A><P><A><E><D><R><S><G><T><P><D><S><I><A><S><S><S><S><A><A><H><P><P><G><V><Q><P><Q><Q><P><P><Y><T><G><A><Q><T><Q><A><G><Q><I><E><G><Q><M><Y><Q><Q><Y><Q><Q><Q><A><G><Y><G><A><Q><Q><P><Q><A><P><P><Q><Q><P><Q><Q><Y><G><I><Q><Y><S><A><S><Y><S><Q><Q><T><G><P><Q><Q><P><Q><Q><F><Q><G><Y><G><Q><Q><P><T><S><Q><A><P><A><P><A><F><S><G><Q><P><Q><Q><L><P><A><Q><P><P><Q><Q><Y><Q><A><S><N><Y><P><A><Q><T><Y><T><A><Q><T><S><Q><P><T><N><Y><T><V><A><P><A><S><Q><P><G><M><A><P><S><Q><P><G><A><Y><Q><P><R><P><G><F><T><S><L><P><G><S><T><M><T><P><P><P><S><G><P><N><P><Y><A><R><N><R><P><P><F><G><Q><G><Y><T><Q><P><G><P><G><Y><R>
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules . Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus .<BOP>
Q92734
Q07011
TNR9_HUMAN
T-cell antigen ILA
Homo
<M><G><N><S><C><Y><N><I><V><A><T><L><L><L><V><L><N><F><E><R><T><R><S><L><Q><D><P><C><S><N><C><P><A><G><T><F><C><D><N><N><R><N><Q><I><C><S><P><C><P><P><N><S><F><S><S><A><G><G><Q><R><T><C><D><I><C><R><Q><C><K><G><V><F><R><T><R><K><E><C><S><S><T><S><N><A><E><C><D><C><T><P><G><F><H><C><L><G><A><G><C><S><M><C><E><Q><D><C><K><Q><G><Q><E><L><T><K><K><G><C><K><D><C><C><F><G><T><F><N><D><Q><K><R><G><I><C><R><P><W><T><N><C><S><L><D><G><K><S><V><L><V><N><G><T><K><E><R><D><V><V><C><G><P><S><P><A><D><L><S><P><G><A><S><S><V><T><P><P><A><P><A><R><E><P><G><H><S><P><Q><I><I><S><F><F><L><A><L><T><S><T><A><L><L><F><L><L><F><F><L><T><L><R><F><S><V><V><K><R><G><R><K><K><L><L><Y><I><F><K><Q><P><F><M><R><P><V><Q><T><T><Q><E><E><D><G><C><S><C><R><F><P><E><E><E><E><G><G><C><E><L>
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.<BOP>
Q07011
P13686
PPA5_HUMAN
Type 5 acid phosphatase
Homo
<M><D><M><W><T><A><L><L><I><L><Q><A><L><L><L><P><S><L><A><D><G><A><T><P><A><L><R><F><V><A><V><G><D><W><G><G><V><P><N><A><P><F><H><T><A><R><E><M><A><N><A><K><E><I><A><R><T><V><Q><I><L><G><A><D><F><I><L><S><L><G><D><N><F><Y><F><T><G><V><Q><D><I><N><D><K><R><F><Q><E><T><F><E><D><V><F><S><D><R><S><L><R><K><V><P><W><Y><V><L><A><G><N><H><D><H><L><G><N><V><S><A><Q><I><A><Y><S><K><I><S><K><R><W><N><F><P><S><P><F><Y><R><L><H><F><K><I><P><Q><T><N><V><S><V><A><I><F><M><L><D><T><V><T><L><C><G><N><S><D><D><F><L><S><Q><Q><P><E><R><P><R><D><V><K><L><A><R><T><Q><L><S><W><L><K><K><Q><L><A><A><A><R><E><D><Y><V><L><V><A><G><H><Y><P><V><W><S><I><A><E><H><G><P><T><H><C><L><V><K><Q><L><R><P><L><L><A><T><Y><G><V><T><A><Y><L><C><G><H><D><H><N><L><Q><Y><L><Q><D><E><N><G><V><G><Y><V><L><S><G><A><G><N><F><M><D><P><S><K><R><H><Q><R><K><V><P><N><G><Y><L><R><F><H><Y><G><T><E><D><S><L><G><G><F><A><Y><V><E><I><S><S><K><E><M><T><V><T><Y><I><E><A><S><G><K><S><L><F><K><T><R><L><P><R><R><A><R><P>
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.<BOP>
P13686
Q9H6L5
RETR1_HUMAN
Reticulophagy receptor 1
Homo
<M><A><S><P><A><P><P><E><H><A><E><E><G><C><P><A><P><A><A><E><E><Q><A><P><P><S><P><P><P><P><Q><A><S><P><A><E><R><Q><Q><Q><E><E><E><A><Q><E><A><G><A><A><E><G><A><G><L><Q><V><E><E><A><A><G><R><A><A><A><A><V><T><W><L><L><G><E><P><V><L><W><L><G><C><R><A><D><E><L><L><S><W><K><R><P><L><R><S><L><L><G><F><V><A><A><N><L><L><F><W><F><L><A><L><T><P><W><R><V><Y><H><L><I><S><V><M><I><L><G><R><V><I><M><Q><I><I><K><D><M><V><L><S><R><T><R><G><A><Q><L><W><R><S><L><S><E><S><W><E><V><I><N><S><K><P><D><E><R><P><R><L><S><H><C><I><A><E><S><W><M><N><F><S><I><F><L><Q><E><M><S><L><F><K><Q><Q><S><P><G><K><F><C><L><L><V><C><S><V><C><T><F><F><T><I><L><G><S><Y><I><P><G><V><I><L><S><Y><L><L><L><L><C><A><F><L><C><P><L><F><K><C><N><D><I><G><Q><K><I><Y><S><K><I><K><S><V><L><L><K><L><D><F><G><I><G><E><Y><I><N><Q><K><K><R><E><R><S><E><A><D><K><E><K><S><H><K><D><D><S><E><L><D><F><S><A><L><C><P><K><I><S><L><T><V><A><A><K><E><L><S><V><S><D><T><D><V><S><E><V><S><W><T><D><N><G><T><F><N><L><S><E><G><Y><T><P><Q><T><D><T><S><D><D><L><D><R><P><S><E><E><V><F><S><R><D><L><S><D><F><P><S><L><E><N><G><M><G><T><N><D><E><D><E><L><S><L><G><L><P><T><E><L><K><R><K><K><E><Q><L><D><S><G><H><R><P><S><K><E><T><Q><S><A><A><G><L><T><L><P><L><N><S><D><Q><T><F><H><L><M><S><N><L><A><G><D><V><I><T><A><A><V><T><A><A><I><K><D><Q><L><E><G><V><Q><Q><A><L><S><Q><A><A><P><I><P><E><E><D><T><D><T><E><E><G><D><D><F><E><L><L><D><Q><S><E><L><D><Q><I><E><S><E><L><G><L><T><Q><D><Q><E><A><E><A><Q><Q><N><K><K><S><S><G><F><L><S><N><L><L><G><G><H>
Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes . Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins . Required for long-term survival of nociceptive and autonomic ganglion neurons .<BOP>
Q9H6L5
P05230
FGF1_HUMAN
Heparin-binding growth factor 1
Homo
<M><A><E><G><E><I><T><T><F><T><A><L><T><E><K><F><N><L><P><P><G><N><Y><K><K><P><K><L><L><Y><C><S><N><G><G><H><F><L><R><I><L><P><D><G><T><V><D><G><T><R><D><R><S><D><Q><H><I><Q><L><Q><L><S><A><E><S><V><G><E><V><Y><I><K><S><T><E><T><G><Q><Y><L><A><M><D><T><D><G><L><L><Y><G><S><Q><T><P><N><E><E><C><L><F><L><E><R><L><E><E><N><H><Y><N><T><Y><I><S><K><K><H><A><E><K><N><W><F><V><G><L><K><K><N><G><S><C><K><R><G><P><R><T><H><Y><G><Q><K><A><I><L><F><L><P><L><P><V><S><S><D>
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 . Can induce angiogenesis .<BOP>
P05230
A0A0A0MT36
KVD21_HUMAN
Immunoglobulin kappa variable 6D-21
Homo
<M><S><P><S><Q><L><I><G><F><L><L><L><W><V><P><A><S><R><G><E><I><V><L><T><Q><S><P><D><F><Q><S><V><T><P><K><E><K><V><T><I><T><C><R><A><S><Q><S><I><G><S><S><L><H><W><Y><Q><Q><K><P><D><Q><S><P><K><L><L><I><K><Y><A><S><Q><S><I><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><N><S><L><E><A><E><D><A><A><A><Y><Y><C><H><Q><S><S><S><L><P>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0A0MT36
P18669
PGAM1_HUMAN
Phosphoglycerate mutase isozyme B
Homo
<M><A><A><Y><K><L><V><L><I><R><H><G><E><S><A><W><N><L><E><N><R><F><S><G><W><Y><D><A><D><L><S><P><A><G><H><E><E><A><K><R><G><G><Q><A><L><R><D><A><G><Y><E><F><D><I><C><F><T><S><V><Q><K><R><A><I><R><T><L><W><T><V><L><D><A><I><D><Q><M><W><L><P><V><V><R><T><W><R><L><N><E><R><H><Y><G><G><L><T><G><L><N><K><A><E><T><A><A><K><H><G><E><A><Q><V><K><I><W><R><R><S><Y><D><V><P><P><P><P><M><E><P><D><H><P><F><Y><S><N><I><S><K><D><R><R><Y><A><D><L><T><E><D><Q><L><P><S><C><E><S><L><K><D><T><I><A><R><A><L><P><F><W><N><E><E><I><V><P><Q><I><K><E><G><K><R><V><L><I><A><A><H><G><N><S><L><R><G><I><V><K><H><L><E><G><L><S><E><E><A><I><M><E><L><N><L><P><T><G><I><P><I><V><Y><E><L><D><K><N><L><K><P><I><K><P><M><Q><F><L><G><D><E><E><T><V><R><K><A><M><E><A><V><A><A><Q><G><K><A><K><K>
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate . Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate .<BOP>
P18669
P01911
DRB1_HUMAN
Human leukocyte antigen DRB1
Homo
<M><V><C><L><K><L><P><G><G><S><C><M><T><A><L><T><V><T><L><M><V><L><S><S><P><L><A><L><S><G><D><T><R><P><R><F><L><W><Q><P><K><R><E><C><H><F><F><N><G><T><E><R><V><R><F><L><D><R><Y><F><Y><N><Q><E><E><S><V><R><F><D><S><D><V><G><E><F><R><A><V><T><E><L><G><R><P><D><A><E><Y><W><N><S><Q><K><D><I><L><E><Q><A><R><A><A><V><D><T><Y><C><R><H><N><Y><G><V><V><E><S><F><T><V><Q><R><R><V><Q><P><K><V><T><V><Y><P><S><K><T><Q><P><L><Q><H><H><N><L><L><V><C><S><V><S><G><F><Y><P><G><S><I><E><V><R><W><F><L><N><G><Q><E><E><K><A><G><M><V><S><T><G><L><I><Q><N><G><D><W><T><F><Q><T><L><V><M><L><E><T><V><P><R><S><G><E><V><Y><T><C><Q><V><E><H><P><S><V><T><S><P><L><T><V><E><W><R><A><R><S><E><S><A><Q><S><K><M><L><S><G><V><G><G><F><V><L><G><L><L><F><L><G><A><G><L><F><I><Y><F><R><N><Q><K><G><H><S><G><L><Q><P><T><G><F><L><S>
(Microbial infection) Acts as a receptor for Epstein-Barr virus on lymphocytes.<BOP>
P01911
O60239
3BP5_HUMAN
SH3 domain-binding protein that preferentially associates with BTK
Homo
<M><D><A><A><L><K><R><S><R><S><E><E><P><A><E><I><L><P><P><A><R><D><E><E><E><E><E><E><E><G><M><E><Q><G><L><E><E><E><E><E><V><D><P><R><I><Q><G><E><L><E><K><L><N><Q><S><T><D><D><I><N><R><R><E><T><E><L><E><D><A><R><Q><K><F><R><S><V><L><V><E><A><T><V><K><L><D><E><L><V><K><K><I><G><K><A><V><E><D><S><K><P><Y><W><E><A><R><R><V><A><R><Q><A><Q><L><E><A><Q><K><A><T><Q><D><F><Q><R><A><T><E><V><L><R><A><A><K><E><T><I><S><L><A><E><Q><R><L><L><E><D><D><K><R><Q><F><D><S><A><W><Q><E><M><L><N><H><A><T><Q><R><V><M><E><A><E><Q><T><K><T><R><S><E><L><V><H><K><E><T><A><A><R><Y><N><A><A><M><G><R><M><R><Q><L><E><K><K><L><K><R><A><I><N><K><S><K><P><Y><F><E><L><K><A><K><Y><Y><V><Q><L><E><Q><L><K><K><T><V><D><D><L><Q><A><K><L><T><L><A><K><G><E><Y><K><M><A><L><K><N><L><E><M><I><S><D><E><I><H><E><R><R><R><S><S><A><M><G><P><R><G><C><G><V><G><A><E><G><S><S><T><S><V><E><D><L><P><G><S><K><P><E><P><D><A><I><S><V><A><S><E><A><F><E><D><D><S><C><S><N><F><V><S><E><D><D><S><E><T><Q><S><V><S><S><F><S><S><G><P><T><S><P><S><E><M><P><D><Q><F><P><A><V><V><R><P><G><S><L><D><L><P><S><P><V><S><L><S><E><F><G><M><M><F><P><V><L><G><P><R><S><E><C><S><G><A><S><S><P><E><C><E><V><E><R><G><D><R><A><E><G><A><E><N><K><T><S><D><K><A><N><N><N><R><G><L><S><S><S><S><G><S><G><G><S><S><K><S><Q><S><S><T><S><P><E><G><Q><A><L><E><N><R><M><K><Q><L><S><L><Q><C><S><K><G><R><D><G><I><I><A><D><I><K><M><V><Q><I><G>
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 . Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.<BOP>
O60239
P0C5Y4
KRA14_HUMAN
Keratin-associated protein 1.4
Homo
<M><A><S><C><S><T><S><G><T><C><G><S><S><C><C><Q><P><S><C><C><E><T><S><C><C><Q><P><S><C><C><Q><T><S><S><C><G><T><G><C><G><I><G><G><G><I><G><Y><G><Q><E><G><S><G><G><S><V><S><T><R><I><R><W><C><H><P><D><C><H><V><E><G><T><C><L><P><P><C><Y><L><V><S><C><T><P><P><S><C><C><Q><L><H><H><A><E><A><S><C><C><R><P><S><Y><C><G><Q><S><C><C><R><P><A><C><C><C><H><C><C><E><P><T><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
P0C5Y4
P59665
DEF1_HUMAN
HNP-2
Homo
<M><R><T><L><A><I><L><A><A><I><L><L><V><A><L><Q><A><Q><A><E><P><L><Q><A><R><A><D><E><V><A><A><A><P><E><Q><I><A><A><D><I><P><E><V><V><V><S><L><A><W><D><E><S><L><A><P><K><H><P><G><S><R><K><N><M><A><C><Y><C><R><I><P><A><C><I><A><G><E><R><R><Y><G><T><C><I><Y><Q><G><R><L><W><A><F><C><C>
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.<BOP>
P59665
Q969T7
5NT3B_HUMAN
N(7)-methylguanylate 5'-phosphatase
Homo
<M><A><E><E><V><S><T><L><M><K><A><T><V><L><M><R><Q><P><G><R><V><Q><E><I><V><G><A><L><R><K><G><G><G><D><R><L><Q><V><I><S><D><F><D><M><T><L><S><R><F><A><Y><N><G><K><R><C><P><S><S><Y><N><I><L><D><N><S><K><I><I><S><E><E><C><R><K><E><L><T><A><L><L><H><H><Y><Y><P><I><E><I><D><P><H><R><T><V><K><E><K><L><P><H><M><V><E><W><W><T><K><A><H><N><L><L><C><Q><Q><K><I><Q><K><F><Q><I><A><Q><V><V><R><E><S><N><A><M><L><R><E><G><Y><K><T><F><F><N><T><L><Y><H><N><N><I><P><L><F><I><F><S><A><G><I><G><D><I><L><E><E><I><I><R><Q><M><K><V><F><H><P><N><I><H><I><V><S><N><Y><M><D><F><N><E><D><G><F><L><Q><G><F><K><G><Q><L><I><H><T><Y><N><K><N><S><S><A><C><E><N><S><G><Y><F><Q><Q><L><E><G><K><T><N><V><I><L><L><G><D><S><I><G><D><L><T><M><A><D><G><V><P><G><V><Q><N><I><L><K><I><G><F><L><N><D><K><V><E><E><R><R><E><R><Y><M><D><S><Y><D><I><V><L><E><K><D><E><T><L><D><V><V><N><G><L><L><Q><H><I><L><C><Q><G><V><Q><L><E><M><Q><G><P>
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate . The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids . Also has weak activity for CMP . UMP and purine nucleotides are poor substrates .<BOP>
Q969T7
Q8NAU1
FNDC5_HUMAN
Irisin
Homo
<M><H><P><G><S><P><S><A><W><P><P><R><A><R><A><A><L><R><L><W><L><G><C><V><C><F><A><L><V><Q><A><D><S><P><S><A><P><V><N><V><T><V><R><H><L><K><A><N><S><A><V><V><S><W><D><V><L><E><D><E><V><V><I><G><F><A><I><S><Q><Q><K><K><D><V><R><M><L><R><F><I><Q><E><V><N><T><T><T><R><S><C><A><L><W><D><L><E><E><D><T><E><Y><I><V><H><V><Q><A><I><S><I><Q><G><Q><S><P><A><S><E><P><V><L><F><K><T><P><R><E><A><E><K><M><A><S><K><N><K><D><E><V><T><M><K><E><M><G><R><N><Q><Q><L><R><T><G><E><V><L><I><I><V><V><V><L><F><M><W><A><G><V><I><A><L><F><C><R><Q><Y><D><I><I><K><D><N><E><P><N><N><N><K><E><K><T><K><S><A><S><E><T><S><T><P><E><H><Q><G><G><G><L><L><R><S><K><I>
Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.<BOP>
Q8NAU1
Q7Z5H4
VN1R5_HUMAN
V1r-like receptor 5
Homo
<M><L><K><L><V><I><I><E><N><M><A><E><I><M><L><F><S><L><D><L><L><L><F><S><T><D><I><L><C><F><N><F><P><S><K><M><I><K><L><P><G><F><I><T><I><Q><I><F><F><Y><P><Q><A><S><F><G><I><S><A><N><T><I><L><L><L><F><H><I><F><T><F><V><F><S><H><R><S><K><S><I><D><M><I><I><S><H><L><S><L><I><H><I><L><L><L><F><T><Q><A><I><L><V><S><L><D><F><F><G><S><Q><N><T><Q><D><D><L><R><Y><K><V><I><V><F><L><N><K><V><M><R><G><L><S><I><C><T><P><C><L><L><S><V><L><Q><A><I><I><S><P><S><I><F><S><L><A><K><L><K><H><P><S><A><S><H><I><L><G><F><F><L><F><S><W><V><L><N><M><F><I><G><V><I><F><C><C><T><L><R><L><P><P><V><K><R><G><Q><S><S><V><C><H><T><A><L><F><L><F><A><H><E><L><H><P><Q><E><T><V><F><H><T><N><D><F><E><G><C><H><L><Y><R><V><H><G><P><L><K><R><L><H><G><D><Y><F><I><Q><T><I><R><G><Y><L><S><A><F><T><Q><P><A><C><P><R><V><S><P><V><K><R><A><S><Q><A><I><L><L><L><V><S><F><V><F><T><Y><W><V><D><F><T><F><S><F><S><G><G><V><T><W><I><N><D><S><L><L><V><W><L><Q><V><I><V><A><N><S><Y><A><A><I><S><P><L><M><L><I><Y><A><D><N><Q><I><F><K><T><L><Q><M><L><W><F><K><Y><L><S><P><P><K><L><M><L><K><F><N><R><Q><C><G><S><T><K><K>
Putative pheromone receptor.<BOP>
Q7Z5H4
Q9H190
SDCB2_HUMAN
Syndecan-binding protein 2
Homo
<M><S><S><L><Y><P><S><L><E><D><L><K><V><D><Q><A><I><Q><A><Q><V><R><A><S><P><K><M><P><A><L><P><V><Q><A><T><A><I><S><P><P><P><V><L><Y><P><N><L><A><E><L><E><N><Y><M><G><L><S><L><S><S><Q><E><V><Q><E><S><L><L><Q><I><P><E><G><D><S><T><A><V><S><G><P><G><P><G><Q><M><V><A><P><V><T><G><Y><S><L><G><V><R><R><A><E><I><K><P><G><V><R><E><I><H><L><C><K><D><E><R><G><K><T><G><L><R><L><R><K><V><D><Q><G><L><F><V><Q><L><V><Q><A><N><T><P><A><S><L><V><G><L><R><F><G><D><Q><L><L><Q><I><D><G><R><D><C><A><G><W><S><S><H><K><A><H><Q><V><V><K><K><A><S><G><D><K><I><V><V><V><V><R><D><R><P><F><Q><R><T><V><T><M><H><K><D><S><M><G><H><V><G><F><V><I><K><K><G><K><I><V><S><L><V><K><G><S><S><A><A><R><N><G><L><L><T><N><H><Y><V><C><E><V><D><G><Q><N><V><I><G><L><K><D><K><K><I><M><E><I><L><A><T><A><G><N><V><V><T><L><T><I><I><P><S><V><I><Y><E><H><M><V><K><K><L><P><P><V><L><L><H><H><T><M><D><H><S><I><P><D><A>
Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival .<BOP>
Q9H190
Q9HAV0
GBB4_HUMAN
Transducin beta chain 4
Homo
<M><S><E><L><E><Q><L><R><Q><E><A><E><Q><L><R><N><Q><I><Q><D><A><R><K><A><C><N><D><A><T><L><V><Q><I><T><S><N><M><D><S><V><G><R><I><Q><M><R><T><R><R><T><L><R><G><H><L><A><K><I><Y><A><M><H><W><G><Y><D><S><R><L><L><V><S><A><S><Q><D><G><K><L><I><I><W><D><S><Y><T><T><N><K><M><H><A><I><P><L><R><S><S><W><V><M><T><C><A><Y><A><P><S><G><N><Y><V><A><C><G><G><L><D><N><I><C><S><I><Y><N><L><K><T><R><E><G><N><V><R><V><S><R><E><L><P><G><H><T><G><Y><L><S><C><C><R><F><L><D><D><S><Q><I><V><T><S><S><G><D><T><T><C><A><L><W><D><I><E><T><A><Q><Q><T><T><T><F><T><G><H><S><G><D><V><M><S><L><S><L><S><P><D><M><R><T><F><V><S><G><A><C><D><A><S><S><K><L><W><D><I><R><D><G><M><C><R><Q><S><F><T><G><H><V><S><D><I><N><A><V><S><F><F><P><N><G><Y><A><F><A><T><G><S><D><D><A><T><C><R><L><F><D><L><R><A><D><Q><E><L><L><L><Y><S><H><D><N><I><I><C><G><I><T><S><V><A><F><S><K><S><G><R><L><L><L><A><G><Y><D><D><F><N><C><N><V><W><D><T><L><K><G><D><R><A><G><V><L><A><G><H><D><N><R><V><S><C><L><G><V><T><D><D><G><M><A><V><A><T><G><S><W><D><S><F><L><R><I><W><N>
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<BOP>
Q9HAV0
Q9NYT0
PLEK2_HUMAN
Pleckstrin-2
Homo
<M><E><D><G><V><L><K><E><G><F><L><V><K><R><G><H><I><V><H><N><W><K><A><R><W><F><I><L><R><Q><N><T><L><V><Y><Y><K><L><E><G><G><R><R><V><T><P><P><K><G><R><I><L><L><D><G><C><T><I><T><C><P><C><L><E><Y><E><N><R><P><L><L><I><K><L><K><T><Q><T><S><T><E><Y><F><L><E><A><C><S><R><E><E><R><D><A><W><A><F><E><I><T><G><A><I><H><A><G><Q><P><G><K><V><Q><Q><L><H><S><L><R><N><S><F><K><L><P><P><H><I><S><L><H><R><I><V><D><K><M><H><D><S><N><T><G><I><R><S><S><P><N><M><E><Q><G><S><T><Y><K><K><T><F><L><G><S><S><L><V><D><W><L><I><S><N><S><F><T><A><S><R><L><E><A><V><T><L><A><S><M><L><M><E><E><N><F><L><R><P><V><G><V><R><S><M><G><A><I><R><S><G><D><L><A><E><Q><F><L><D><D><S><T><A><L><Y><T><F><A><E><S><Y><K><K><K><I><S><P><K><E><E><I><S><L><S><T><V><E><L><S><G><T><V><V><K><Q><G><Y><L><A><K><Q><G><H><K><R><K><N><W><K><V><R><R><F><V><L><R><K><D><P><A><F><L><H><Y><Y><D><P><S><K><E><E><N><R><P><V><G><G><F><S><L><R><G><S><L><V><S><A><L><E><D><N><G><V><P><T><G><V><K><G><N><V><Q><G><N><L><F><K><V><I><T><K><D><D><T><H><Y><Y><I><Q><A><S><S><K><A><E><R><A><E><W><I><E><A><I><K><K><L><T>
May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.<BOP>
Q9NYT0
Q8TAQ5
ZN420_HUMAN
Zinc finger protein 420
Homo
<M><A><R><K><L><V><M><F><R><D><V><A><I><D><F><S><Q><E><E><W><E><C><L><D><S><A><Q><R><D><L><Y><R><D><V><M><L><E><N><Y><S><N><L><V><S><L><D><L><P><S><R><C><A><S><K><D><L><S><P><E><K><N><T><Y><E><T><E><L><S><Q><W><E><M><S><D><R><L><E><N><C><D><L><E><E><S><N><S><R><D><Y><L><E><A><K><G><K><M><E><K><Q><Q><E><N><Q><K><E><Y><F><R><Q><G><M><I><I><Y><D><K><M><S><I><F><N><Q><H><T><Y><L><S><Q><H><S><R><C><H><S><T><E><K><P><Y><K><C><K><E><C><G><K><A><F><R><R><A><S><H><L><T><Q><H><Q><S><I><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><R><D><S><Q><L><S><L><H><Q><R><L><H><T><G><E><K><P><Y><A><C><K><E><C><G><K><A><F><T><Q><S><S><Q><L><I><L><H><H><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><I><R><S><S><Q><L><T><R><H><Q><K><V><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><T><Q><N><S><Q><L><T><L><H><Q><R><L><H><T><G><E><K><L><Y><E><C><K><E><C><R><K><V><F><T><Q><L><S><Q><L><I><L><H><K><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><I><C><G><S><Q><L><S><Q><H><Q><K><I><H><N><G><E><K><P><Y><E><C><K><E><C><G><R><A><F><I><R><G><S><L><L><M><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><I><R><G><S><Q><L><T><Q><H><Q><R><I><H><T><N><E><K><P><Y><E><C><K><E><C><G><K><M><F><S><H><G><S><Q><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><N><R><G><S><L><L><T><R><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><T><F><S><R><G><S><E><L><T><Q><H><E><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><S><F><I><R><G><S><Q><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><R><M><A><F><T><Q><S><S><H><L><S><Q><H><Q><R><L><H><T><G><E><K><P><Y><V><C><N><E><C><G><K><A><F><A><R><G><L><L><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><I><R><G><S><Q><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><H><G><S><Q><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><E><C><R><E><C><R><K><A><F><T><Q><S><S><H><L><S><R><H><Q><R><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><T><R><G><S><Q><L><T><Q><H><Q><R><I><H><I><S><E><K><S><F><E><Y><K><E><C><G><I><D><F><S><H><G><S><Q><V><Y><M>
May be involved in transcriptional regulation.<BOP>
Q8TAQ5
Q9P0R6
GSKIP_HUMAN
GSK3beta interaction protein
Homo
<M><E><T><D><C><N><P><M><E><L><S><S><M><S><G><F><E><E><G><S><E><L><N><G><F><E><G><T><D><M><K><D><M><R><L><E><A><E><A><V><V><N><D><V><L><F><A><V><N><N><M><F><V><S><K><S><L><R><C><A><D><D><V><A><Y><I><N><V><E><T><K><E><R><N><R><Y><C><L><E><L><T><E><A><G><L><K><V><V><G><Y><A><F><D><Q><V><D><D><H><L><Q><T><P><Y><H><E><T><V><Y><S><L><L><D><T><L><S><P><A><Y><R><E><A><F><G><N><A><L><L><Q><R><L><E><A><L><K><R><D><G><Q><S>
A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets . The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively . Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B . During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression .<BOP>
Q9P0R6
P18848
ATF4_HUMAN
Tax-responsive enhancer element-binding protein 67
Homo
<M><T><E><M><S><F><L><S><S><E><V><L><V><G><D><L><M><S><P><F><D><Q><S><G><L><G><A><E><E><S><L><G><L><L><D><D><Y><L><E><V><A><K><H><F><K><P><H><G><F><S><S><D><K><A><K><A><G><S><S><E><W><L><A><V><D><G><L><V><S><P><S><N><N><S><K><E><D><A><F><S><G><T><D><W><M><L><E><K><M><D><L><K><E><F><D><L><D><A><L><L><G><I><D><D><L><E><T><M><P><D><D><L><L><T><T><L><D><D><T><C><D><L><F><A><P><L><V><Q><E><T><N><K><Q><P><P><Q><T><V><N><P><I><G><H><L><P><E><S><L><T><K><P><D><Q><V><A><P><F><T><F><L><Q><P><L><P><L><S><P><G><V><L><S><S><T><P><D><H><S><F><S><L><E><L><G><S><E><V><D><I><T><E><G><D><R><K><P><D><Y><T><A><Y><V><A><M><I><P><Q><C><I><K><E><E><D><T><P><S><D><N><D><S><G><I><C><M><S><P><E><S><Y><L><G><S><P><Q><H><S><P><S><T><R><G><S><P><N><R><S><L><P><S><P><G><V><L><C><G><S><A><R><P><K><P><Y><D><P><P><G><E><K><M><V><A><A><K><V><K><G><E><K><L><D><K><K><L><K><K><M><E><Q><N><K><T><A><A><T><R><Y><R><Q><K><K><R><A><E><Q><E><A><L><T><G><E><C><K><E><L><E><K><K><N><E><A><L><K><E><R><A><D><S><L><A><K><E><I><Q><Y><L><K><D><L><I><E><E><V><R><K><A><R><G><K><K><R><V><P>
(Microbial infection) Binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.<BOP>
P18848
P22362
CCL1_HUMAN
T lymphocyte-secreted protein I-309
Homo
<M><Q><I><I><T><T><A><L><V><C><L><L><L><A><G><M><W><P><E><D><V><D><S><K><S><M><Q><V><P><F><S><R><C><C><F><S><F><A><E><Q><E><I><P><L><R><A><I><L><C><Y><R><N><T><S><S><I><C><S><N><E><G><L><I><F><K><L><K><R><G><K><E><A><C><A><L><D><T><V><G><W><V><Q><R><H><R><K><M><L><R><H><C><P><S><K><R><K>
Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.<BOP>
P22362
Q8NG94
O11H1_HUMAN
Olfactory receptor OR22-1
Homo
<M><C><P><L><T><L><Q><V><T><G><L><M><N><V><S><E><P><N><S><S><F><A><F><V><N><E><F><I><L><Q><G><F><S><C><E><W><T><I><Q><I><F><L><F><S><L><F><T><T><T><Y><A><L><T><I><T><G><N><G><A><I><A><F><V><L><W><C><D><R><R><L><H><T><P><M><Y><M><F><L><G><N><F><S><F><L><E><I><W><Y><V><S><S><T><V><P><K><M><L><V><N><F><L><S><E><K><K><N><I><S><F><A><G><C><F><L><Q><F><Y><F><F><F><S><L><G><T><S><E><C><L><L><L><T><V><M><A><F><D><Q><Y><L><A><I><C><R><P><L><L><Y><P><N><I><M><T><G><H><L><Y><A><K><L><V><I><L><C><W><V><C><G><F><L><W><F><L><I><P><I><V><L><I><S><Q><M><P><F><C><G><P><N><I><I><D><H><V><V><C><D><P><G><P><R><F><A><L><D><C><V><S><A><P><R><I><Q><L><F><C><Y><T><L><S><S><L><V><I><F><G><N><F><L><F><I><I><G><S><Y><T><L><V><L><K><A><M><L><G><M><P><S><S><T><G><R><H><K><A><F><S><T><C><G><S><H><L><A><V><V><S><L><C><Y><S><S><L><M><V><M><Y><V><S><P><G><L><G><H><S><T><G><M><Q><K><I><E><T><L><F><Y><A><M><V><T><P><L><F><N><P><L><I><Y><S><L><Q><N><K><E><I><K><A><A><L><R><K><V><L><G><S><S><N><I><I>
Odorant receptor.<BOP>
Q8NG94
Q9BTP7
FAP24_HUMAN
Fanconi anemia-associated protein of 24 kDa
Homo
<M><E><K><N><P><P><D><D><T><G><P><V><H><V><P><L><G><H><I><V><A><N><E><K><W><R><G><S><Q><L><A><Q><E><M><Q><G><K><I><K><L><I><F><E><D><G><L><T><P><D><F><Y><L><S><N><R><C><C><I><L><Y><V><T><E><A><D><L><V><A><G><N><G><Y><R><K><R><L><V><R><V><R><N><S><N><N><L><K><G><I><V><V><V><E><K><T><R><M><S><E><Q><Y><F><P><A><L><Q><K><F><T><V><L><D><L><G><M><V><L><L><P><V><A><S><Q><M><E><A><S><C><L><V><I><Q><L><V><Q><E><Q><T><K><E><P><S><K><N><P><L><L><G><K><K><R><A><L><L><L><S><E><P><S><L><L><R><T><V><Q><Q><I><P><G><V><G><K><V><K><A><P><L><L><L><Q><K><F><P><S><I><Q><Q><L><S><N><A><S><I><G><E><L><E><Q><V><V><G><Q><A><V><A><Q><Q><I><H><A><F><F><T><Q><P><R>
Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.<BOP>
Q9BTP7
Q8TBC5
ZSC18_HUMAN
Zinc finger protein 447
Homo
<M><L><P><L><E><K><A><F><A><S><P><R><S><S><P><A><P><P><D><L><P><T><P><G><S><A><A><G><V><Q><Q><E><E><P><E><T><I><P><E><R><T><P><A><D><L><E><F><S><R><L><R><F><R><E><F><V><Y><Q><E><A><A><G><P><H><Q><T><L><A><R><L><H><E><L><C><R><Q><W><L><M><P><E><A><R><S><K><E><Q><M><L><E><L><L><V><L><E><Q><F><L><G><I><L><P><D><K><V><R><P><W><V><V><A><Q><Y><P><E><S><C><K><K><A><A><S><L><V><E><G><L><A><D><V><L><E><E><P><G><M><L><L><G><S><P><A><G><S><S><S><I><L><S><D><G><V><Y><E><R><H><M><D><P><L><L><L><P><G><E><L><A><S><P><S><Q><A><L><G><A><G><E><I><P><A><P><S><E><T><P><W><L><S><P><D><P><L><F><L><E><Q><R><R><V><R><E><A><K><T><E><E><D><G><P><A><N><T><E><Q><K><L><K><S><F><P><E><D><P><Q><H><L><G><E><W><G><H><L><D><P><A><E><E><N><L><K><S><Y><R><K><L><L><L><W><G><Y><Q><L><S><Q><P><D><A><A><S><R><L><D><T><E><E><L><R><L><V><E><R><D><P><Q><G><S><S><L><P><E><G><G><R><R><Q><E><S><A><G><C><A><C><E><E><A><A><P><A><G><V><L><P><E><L><P><T><E><A><P><P><G><D><A><L><A><D><P><P><S><G><T><T><E><E><E><E><E><Q><P><G><K><A><P><D><P><Q><D><P><Q><D><A><E><S><D><S><A><T><G><S><Q><R><Q><S><V><I><Q><Q><P><A><P><D><R><G><T><A><K><L><G><T><K><R><P><H><P><E><D><G><D><G><Q><S><L><E><G><V><S><S><S><G><D><S><A><G><L><E><A><G><Q><G><P><G><A><D><E><P><G><L><S><R><G><K><P><Y><A><C><G><E><C><G><E><A><F><A><W><L><S><H><L><M><E><H><H><S><S><H><G><G><R><K><R><Y><A><C><Q><G><C><W><K><T><F><H><F><S><L><A><L><A><E><H><Q><K><T><H><E><K><E><K><S><Y><A><L><G><G><A><R><G><P><Q><P><S><T><R><E><A><Q><A><G><A><R><A><G><G><P><P><E><S><V><E><G><E><A><P><P><A><P><P><E><A><Q><R>
May be involved in transcriptional regulation.<BOP>
Q8TBC5
Q9UBS0
KS6B2_HUMAN
p70 ribosomal S6 kinase beta
Homo
<M><A><A><V><F><D><L><D><L><E><T><E><E><G><S><E><G><E><G><E><P><E><L><S><P><A><D><A><C><P><L><A><E><L><R><A><A><G><L><E><P><V><G><H><Y><E><E><V><E><L><T><E><T><S><V><N><V><G><P><E><R><I><G><P><H><C><F><E><L><L><R><V><L><G><K><G><G><Y><G><K><V><F><Q><V><R><K><V><Q><G><T><N><L><G><K><I><Y><A><M><K><V><L><R><K><A><K><I><V><R><N><A><K><D><T><A><H><T><R><A><E><R><N><I><L><E><S><V><K><H><P><F><I><V><E><L><A><Y><A><F><Q><T><G><G><K><L><Y><L><I><L><E><C><L><S><G><G><E><L><F><T><H><L><E><R><E><G><I><F><L><E><D><T><A><C><F><Y><L><A><E><I><T><L><A><L><G><H><L><H><S><Q><G><I><I><Y><R><D><L><K><P><E><N><I><M><L><S><S><Q><G><H><I><K><L><T><D><F><G><L><C><K><E><S><I><H><E><G><A><V><T><H><T><F><C><G><T><I><E><Y><M><A><P><E><I><L><V><R><S><G><H><N><R><A><V><D><W><W><S><L><G><A><L><M><Y><D><M><L><T><G><S><P><P><F><T><A><E><N><R><K><K><T><M><D><K><I><I><R><G><K><L><A><L><P><P><Y><L><T><P><D><A><R><D><L><V><K><K><F><L><K><R><N><P><S><Q><R><I><G><G><G><P><G><D><A><A><D><V><Q><R><H><P><F><F><R><H><M><N><W><D><D><L><L><A><W><R><V><D><P><P><F><R><P><C><L><Q><S><E><E><D><V><S><Q><F><D><T><R><F><T><R><Q><T><P><V><D><S><P><D><D><T><A><L><S><E><S><A><N><Q><A><F><L><G><F><T><Y><V><A><P><S><V><L><D><S><I><K><E><G><F><S><F><Q><P><K><L><R><S><P><R><R><L><N><S><S><P><R><A><P><V><S><P><L><K><F><S><P><F><E><G><F><R><P><S><P><S><L><P><E><P><T><E><L><P><L><P><P><L><L><P><P><P><P><P><S><T><T><A><P><L><P><I><R><P><P><S><G><T><K><K><S><K><R><G><R><G><R><P><G><R>
Phosphorylates specifically ribosomal protein S6 . Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 .<BOP>
Q9UBS0
Q92681
RSCA1_HUMAN
Transporter regulator RS1
Homo
<M><S><S><L><P><T><S><D><G><F><N><H><P><A><R><S><S><G><Q><S><P><D><V><G><N><P><M><S><L><A><R><S><V><S><A><S><V><C><P><I><K><P><S><D><S><D><R><I><E><P><K><A><V><K><A><L><K><A><S><A><E><F><Q><L><N><S><E><K><K><E><H><L><S><L><Q><D><L><S><D><H><A><S><S><A><D><H><A><P><T><D><Q><S><P><A><M><P><M><Q><N><S><S><E><E><I><T><V><A><G><N><L><E><K><S><A><E><R><S><T><Q><G><L><K><F><H><L><H><T><R><Q><E><A><S><L><S><V><T><S><T><R><M><H><E><P><Q><M><F><L><G><E><K><D><W><H><P><E><N><Q><N><L><S><Q><V><S><D><P><Q><Q><H><E><E><P><G><N><E><Q><Y><E><V><A><Q><Q><K><A><S><H><D><Q><E><Y><L><C><N><I><G><D><L><E><L><P><E><E><R><Q><Q><N><Q><H><K><I><V><D><L><E><A><T><M><K><G><N><G><L><P><Q><N><V><D><P><P><S><A><K><K><S><I><P><S><S><E><C><S><G><C><S><N><S><E><T><F><M><E><I><D><T><A><Q><Q><S><L><V><T><L><L><N><S><T><G><R><Q><N><A><N><V><K><N><I><G><A><L><D><L><T><L><D><N><P><L><M><E><V><E><T><S><K><C><N><P><S><S><E><I><L><N><D><S><I><S><T><Q><D><L><Q><P><P><E><T><N><V><E><I><P><G><T><N><K><E><Y><G><H><Y><S><S><P><S><L><C><G><S><C><Q><P><S><V><E><S><A><E><E><S><C><P><S><I><T><A><A><L><K><E><L><H><E><L><L><V><V><S><S><K><P><A><S><E><N><T><S><E><E><V><I><C><Q><S><E><T><I><A><E><G><Q><T><S><I><K><D><L><S><E><R><W><T><Q><N><E><H><L><T><Q><N><E><Q><C><P><Q><V><S><F><H><Q><A><I><S><V><S><V><E><T><E><K><L><T><G><T><S><S><D><T><G><R><E><A><V><E><N><V><N><F><R><S><L><G><D><G><L><S><T><D><K><E><G><V><P><K><S><R><E><S><I><N><K><N><R><S><V><T><V><T><S><A><K><T><S><N><Q><L><H><C><T><L><G><V><E><I><S><P><K><L><L><A><G><E><E><D><A><L><N><Q><T><S><E><Q><T><K><S><L><S><S><N><F><I><L><V><K><D><L><G><Q><G><I><Q><N><S><V><T><D><R><P><E><T><R><E><N><V><C><P><D><A><S><R><P><L><L><E><Y><E><P><P><T><S><H><P><S><S><S><P><A><I><L><P><P><L><I><F><P><A><T><D><I><D><R><I><L><R><A><G><F><T><L><Q><E><A><L><G><A><L><H><R><V><G><G><N><A><D><L><A><L><L><V><L><L><A><K><N><I><V><V><P><T>
Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.<BOP>
Q92681
P01714
LV319_HUMAN
Ig lambda chain V-III region SH
Homo
<M><A><W><T><P><L><W><L><T><L><L><T><L><C><I><G><S><V><V><S><S><E><L><T><Q><D><P><A><V><S><V><A><L><G><Q><T><V><R><I><T><C><Q><G><D><S><L><R><S><Y><Y><A><S><W><Y><Q><Q><K><P><G><Q><A><P><V><L><V><I><Y><G><K><N><N><R><P><S><G><I><P><D><R><F><S><G><S><S><S><G><N><T><A><S><L><T><I><T><G><A><Q><A><E><D><E><A><D><Y><Y><C><N><S><R><D><S><S>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P01714
Q8N387
MUC15_HUMAN
Mucin-15
Homo
<M><L><A><L><A><K><I><L><L><I><S><T><L><F><Y><S><L><L><S><G><S><H><G><K><E><N><Q><D><I><N><T><T><Q><N><I><A><E><V><F><K><T><M><E><N><K><P><I><S><L><E><S><E><A><N><L><N><S><D><K><E><N><I><T><T><S><N><L><K><A><S><H><S><P><P><L><N><L><P><N><N><S><H><G><I><T><D><F><S><S><N><S><S><A><E><H><S><L><G><S><L><K><P><T><S><T><I><S><T><S><P><P><L><I><H><S><F><V><S><K><V><P><W><N><A><P><I><A><D><E><D><L><L><P><I><S><A><H><P><N><A><T><P><A><L><S><S><E><N><F><T><W><S><L><V><N><D><T><V><K><T><P><D><N><S><S><I><T><V><S><I><L><S><S><E><P><T><S><P><S><V><T><P><L><I><V><E><P><S><G><W><L><T><T><N><S><D><S><F><T><G><F><T><P><Y><Q><E><K><T><T><L><Q><P><T><L><K><F><T><N><N><S><K><L><F><P><N><T><S><D><P><Q><K><E><N><R><N><T><G><I><V><F><G><A><I><L><G><A><I><L><G><V><S><L><L><T><L><V><G><Y><L><L><C><G><K><R><K><T><D><S><F><S><H><R><R><L><Y><D><D><R><N><E><P><V><L><R><L><D><N><A><P><E><P><Y><D><V><S><F><G><N><S><S><Y><Y><N><P><T><L><N><D><S><A><M><P><E><S><E><E><N><A><R><D><G><I><P><M><D><D><I><P><P><L><R><T><S><V>
May play a role in the cell adhesion to the extracellular matrix.<BOP>
Q8N387
P01571
IFN17_HUMAN
Interferon alpha-T
Homo
<M><A><L><S><F><S><L><L><M><A><V><L><V><L><S><Y><K><S><I><C><S><L><G><C><D><L><P><Q><T><H><S><L><G><N><R><R><A><L><I><L><L><A><Q><M><G><R><I><S><P><F><S><C><L><K><D><R><H><D><F><G><L><P><Q><E><E><F><D><G><N><Q><F><Q><K><T><Q><A><I><S><V><L><H><E><M><I><Q><Q><T><F><N><L><F><S><T><E><D><S><S><A><A><W><E><Q><S><L><L><E><K><F><S><T><E><L><Y><Q><Q><L><N><N><L><E><A><C><V><I><Q><E><V><G><M><E><E><T><P><L><M><N><E><D><S><I><L><A><V><R><K><Y><F><Q><R><I><T><L><Y><L><T><E><K><K><Y><S><P><C><A><W><E><V><V><R><A><E><I><M><R><S><L><S><F><S><T><N><L><Q><K><I><L><R><R><K><D>
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<BOP>
P01571
Q9BT22
ALG1_HUMAN
Mannosyltransferase-1
Homo
<M><A><A><S><C><L><V><L><L><A><L><C><L><L><L><P><L><L><L><L><G><G><W><K><R><W><R><R><G><R><A><A><R><H><V><V><A><V><V><L><G><D><V><G><R><S><P><R><M><Q><Y><H><A><L><S><L><A><M><H><G><F><S><V><T><L><L><G><F><C><N><S><K><P><H><D><E><L><L><Q><N><N><R><I><Q><I><V><G><L><T><E><L><Q><S><L><A><V><G><P><R><V><F><Q><Y><G><V><K><V><V><L><Q><A><M><Y><L><L><W><K><L><M><W><R><E><P><G><A><Y><I><F><L><Q><N><P><P><G><L><P><S><I><A><V><C><W><F><V><G><C><L><C><G><S><K><L><V><I><D><W><H><N><Y><G><Y><S><I><M><G><L><V><H><G><P><N><H><P><L><V><L><L><A><K><W><Y><E><K><F><F><G><R><L><S><H><L><N><L><C><V><T><N><A><M><R><E><D><L><A><D><N><W><H><I><R><A><V><T><V><Y><D><K><P><A><S><F><F><K><E><T><P><L><D><L><Q><H><R><L><F><M><K><L><G><S><M><H><S><P><F><R><A><R><S><E><P><E><D><P><V><T><E><R><S><A><F><T><E><R><D><A><G><S><G><L><V><T><R><L><R><E><R><P><A><L><L><V><S><S><T><S><W><T><E><D><E><D><F><S><I><L><L><A><A><L><E><K><F><E><Q><L><T><L><D><G><H><N><L><P><S><L><V><C><V><I><T><G><K><G><P><L><R><E><Y><Y><S><R><L><I><H><Q><K><H><F><Q><H><I><Q><V><C><T><P><W><L><E><A><E><D><Y><P><L><L><L><G><S><A><D><L><G><V><C><L><H><T><S><S><S><G><L><D><L><P><M><K><V><V><D><M><F><G><C><C><L><P><V><C><A><V><N><F><K><C><L><H><E><L><V><K><H><E><E><N><G><L><V><F><E><D><S><E><E><L><A><A><Q><L><Q><M><L><F><S><N><F><P><D><P><A><G><K><L><N><Q><F><R><K><N><L><R><E><S><Q><Q><L><R><W><D><E><S><W><V><Q><T><V><L><P><L><V><M><D><T>
Catalyzes the addition of the first of nine mannose moieties to form a dolichol-lipid linked oligosaccharide intermediate required for proper N-linked glycosylation.<BOP>
Q9BT22
Q9Y2D2
S35A3_HUMAN
Solute carrier family 35 member A3
Homo
<M><F><A><N><L><K><Y><V><S><L><G><I><L><V><F><Q><T><T><S><L><V><L><T><M><R><Y><S><R><T><L><K><E><E><G><P><R><Y><L><S><S><T><A><V><V><V><A><E><L><L><K><I><M><A><C><I><L><L><V><Y><K><D><S><K><C><S><L><R><A><L><N><R><V><L><H><D><E><I><L><N><K><P><M><E><T><L><K><L><A><I><P><S><G><I><Y><T><L><Q><N><N><L><L><Y><V><A><L><S><N><L><D><A><A><T><Y><Q><V><T><Y><Q><L><K><I><L><T><T><A><L><F><S><V><S><M><L><S><K><K><L><G><V><Y><Q><W><L><S><L><V><I><L><M><T><G><V><A><F><V><Q><W><P><S><D><S><Q><L><D><S><K><E><L><S><A><G><S><Q><F><V><G><L><M><A><V><L><T><A><C><F><S><S><G><F><A><G><V><Y><F><E><K><I><L><K><E><T><K><Q><S><V><W><I><R><N><I><Q><L><G><F><F><G><S><I><F><G><L><M><G><V><Y><I><Y><D><G><E><L><V><S><K><N><G><F><F><Q><G><Y><N><R><L><T><W><I><V><V><V><L><Q><A><L><G><G><L><V><I><A><A><V><I><K><Y><A><D><N><I><L><K><G><F><A><T><S><L><S><I><I><L><S><T><L><I><S><Y><F><W><L><Q><D><F><V><P><T><S><V><F><F><L><G><A><I><L><V><I><T><A><T><F><L><Y><G><Y><D><P><K><P><A><G><N><P><T><K><A>
Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides.<BOP>
Q9Y2D2
Q8NAA4
A16L2_HUMAN
WD repeat-containing protein 80
Homo
<M><A><G><P><G><V><P><G><A><P><A><A><R><W><K><R><H><I><V><R><Q><L><R><L><R><D><R><T><Q><K><A><L><F><L><E><L><V><P><A><Y><N><H><L><L><E><K><A><E><L><L><D><K><F><S><K><K><L><Q><P><E><P><N><S><V><T><P><T><T><H><Q><G><P><W><E><E><S><E><L><D><S><D><Q><V><P><S><L><V><A><L><R><V><K><W><Q><E><E><E><E><G><L><R><L><V><C><G><E><M><A><Y><Q><V><V><E><K><G><A><A><L><G><T><L><E><S><E><L><Q><Q><R><Q><S><R><L><A><A><L><E><A><R><V><A><Q><L><R><E><A><R><A><Q><Q><A><Q><Q><V><E><E><W><R><A><Q><N><A><V><Q><R><A><A><Y><E><A><L><R><A><H><V><G><L><R><E><A><A><L><R><R><L><Q><E><E><A><R><D><L><L><E><R><L><V><Q><R><K><A><R><A><A><A><E><R><N><L><R><N><E><R><R><E><R><A><K><Q><A><R><V><S><Q><E><L><K><K><A><A><K><R><T><V><S><I><S><E><G><P><D><T><L><G><D><G><M><R><E><R><R><E><T><L><A><L><A><P><E><P><E><P><L><E><K><E><A><C><E><K><W><K><R><P><F><R><S><A><S><A><T><S><L><T><L><S><H><C><V><D><V><V><K><G><L><L><D><F><K><K><R><R><G><H><S><I><G><G><A><P><E><Q><R><Y><Q><I><I><P><V><C><V><A><A><R><L><P><T><R><A><Q><D><V><L><D><A><H><L><S><E><V><N><A><V><R><F><G><P><N><S><S><L><L><A><T><G><G><A><D><R><L><I><H><L><W><N><V><V><G><S><R><L><E><A><N><Q><T><L><E><G><A><G><G><S><I><T><S><V><D><F><D><P><S><G><Y><Q><V><L><A><A><T><Y><N><Q><A><A><Q><L><W><K><V><G><E><A><Q><S><K><E><T><L><S><G><H><K><D><K><V><T><A><A><K><F><K><L><T><R><H><Q><A><V><T><G><S><R><D><R><T><V><K><E><W><D><L><G><R><A><Y><C><S><R><T><I><N><V><L><S><Y><C><N><D><V><V><C><G><D><H><I><I><I><S><G><H><N><D><Q><K><I><R><F><W><D><S><R><G><P><H><C><T><Q><V><I><P><V><Q><G><R><V><T><S><L><S><L><S><H><D><Q><L><H><L><L><S><C><S><R><D><N><T><L><K><V><I><D><L><R><V><S><N><I><R><Q><V><F><R><A><D><G><F><K><C><G><S><D><W><T><K><A><V><F><S><P><D><R><S><Y><A><L><A><G><S><C><D><G><A><L><Y><I><W><D><V><D><T><G><K><L><E><S><R><L><Q><G><P><H><C><A><A><V><N><A><V><A><W><C><Y><S><G><S><H><M><V><S><V><D><Q><G><R><K><V><V><L><W><Q>
May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.<BOP>
Q8NAA4
Q8WUA8
TSK_HUMAN
Leucine-rich repeat-containing protein 54
Homo
<M><P><W><P><L><L><L><L><L><A><V><S><G><A><Q><T><T><R><P><C><F><P><G><C><Q><C><E><V><E><T><F><G><L><F><D><S><F><S><L><T><R><V><D><C><S><G><L><G><P><H><I><M><P><V><P><I><P><L><D><T><A><H><L><D><L><S><S><N><R><L><E><M><V><N><E><S><V><L><A><G><P><G><Y><T><T><L><A><G><L><D><L><S><H><N><L><L><T><S><I><S><P><T><A><F><S><R><L><R><Y><L><E><S><L><D><L><S><H><N><G><L><T><A><L><P><A><E><S><F><T><S><S><P><L><S><D><V><N><L><S><H><N><Q><L><R><E><V><S><V><S><A><F><T><T><H><S><Q><G><R><A><L><H><V><D><L><S><H><N><L><I><H><R><L><V><P><H><P><T><R><A><G><L><P><A><P><T><I><Q><S><L><N><L><A><W><N><R><L><H><A><V><P><N><L><R><D><L><P><L><R><Y><L><S><L><D><G><N><P><L><A><V><I><G><P><G><A><F><A><G><L><G><G><L><T><H><L><S><L><A><S><L><Q><R><L><P><E><L><A><P><S><G><F><R><E><L><P><G><L><Q><V><L><D><L><S><G><N><P><K><L><N><W><A><G><A><E><V><F><S><G><L><S><S><L><Q><E><L><D><L><S><G><T><N><L><V><P><L><P><E><A><L><L><L><H><L><P><A><L><Q><S><V><S><V><G><Q><D><V><R><C><R><R><L><V><R><E><G><T><Y><P><R><R><P><G><S><S><P><K><V><A><L><H><C><V><D><T><R><D><S><A><A><R><G><P><T><I><L>
Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown
Q8WUA8
Q9NRP0
OSTC_HUMAN
Hydrophobic protein HSF-28
Homo
<M><E><T><L><Y><R><V><P><F><L><V><L><E><C><P><N><L><K><L><K><K><P><P><W><L><H><M><P><S><A><M><T><V><Y><A><L><V><V><V><S><Y><F><L><I><T><G><G><I><I><Y><D><V><I><V><E><P><P><S><V><G><S><M><T><D><E><H><G><H><Q><R><P><V><A><F><L><A><Y><R><V><N><G><Q><Y><I><M><E><G><L><A><S><S><F><L><F><T><M><G><G><L><G><F><I><I><L><D><R><S><N><A><P><N><I><P><K><L><N><R><F><L><L><L><F><I><G><F><V><C><V><L><L><S><F><F><M><A><R><V><F><M><R><M><K><L><P><G><Y><L><M><G>
Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.<BOP>
Q9NRP0
Q9H147
TDIF1_HUMAN
Terminal deoxynucleotidyltransferase-interacting factor 1
Homo
<M><G><A><T><G><D><A><E><Q><P><R><G><P><S><G><A><E><R><G><G><L><E><L><G><D><A><G><A><A><G><Q><L><V><L><T><N><P><W><N><I><M><I><K><H><R><Q><V><Q><R><R><G><R><R><S><Q><M><T><T><S><F><T><D><P><A><I><S><M><D><L><L><R><A><V><L><Q><P><S><I><N><E><E><I><Q><T><V><F><N><K><Y><M><K><F><F><Q><K><A><A><L><N><V><R><D><N><V><G><E><E><V><D><A><E><Q><L><I><Q><E><A><C><R><S><C><L><E><Q><A><K><L><L><F><S><D><G><E><K><V><I><P><R><L><T><H><E><L><P><G><I><K><R><G><R><Q><A><E><E><E><C><A><H><R><G><S><P><L><P><K><K><R><K><G><R><P><P><G><H><I><L><S><S><D><R><A><A><A><G><M><V><W><K><P><K><S><C><E><P><I><R><R><E><G><P><K><W><D><P><A><R><L><N><E><S><T><T><F><V><L><G><S><R><A><N><K><A><L><G><M><G><G><T><R><G><R><I><Y><I><K><H><P><H><L><F><K><Y><A><A><D><P><Q><D><K><H><W><L><A><E><Q><H><H><M><R><A><T><G><G><K><M><A><Y><L><L><I><E><E><D><I><R><D><L><A><A><S><D><D><Y><R><G><C><L><D><L><K><L><E><E><L><K><S><F><V><L><P><S><W><M><V><E><K><M><R><K><Y><M><E><T><L><R><T><E><N><E><H><R><A><V><E><A><P><P><Q><T>
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) . Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.<BOP>
Q9H147
P31321
KAP1_HUMAN
cAMP-dependent protein kinase type I-beta regulatory subunit
Homo
<M><A><S><P><P><A><C><P><S><E><E><D><E><S><L><K><G><C><E><L><Y><V><Q><L><H><G><I><Q><Q><V><L><K><D><C><I><V><H><L><C><I><S><K><P><E><R><P><M><K><F><L><R><E><H><F><E><K><L><E><K><E><E><N><R><Q><I><L><A><R><Q><K><S><N><S><Q><S><D><S><H><D><E><E><V><S><P><T><P><P><N><P><V><V><K><A><R><R><R><R><G><G><V><S><A><E><V><Y><T><E><E><D><A><V><S><Y><V><R><K><V><I><P><K><D><Y><K><T><M><T><A><L><A><K><A><I><S><K><N><V><L><F><A><H><L><D><D><N><E><R><S><D><I><F><D><A><M><F><P><V><T><H><I><A><G><E><T><V><I><Q><Q><G><N><E><G><D><N><F><Y><V><V><D><Q><G><E><V><D><V><Y><V><N><G><E><W><V><T><N><I><S><E><G><G><S><F><G><E><L><A><L><I><Y><G><T><P><R><A><A><T><V><K><A><K><T><D><L><K><L><W><G><I><D><R><D><S><Y><R><R><I><L><M><G><S><T><L><R><K><R><K><M><Y><E><E><F><L><S><K><V><S><I><L><E><S><L><E><K><W><E><R><L><T><V><A><D><A><L><E><P><V><Q><F><E><D><G><E><K><I><V><V><Q><G><E><P><G><D><D><F><Y><I><I><T><E><G><T><A><S><V><L><Q><R><R><S><P><N><E><E><Y><V><E><V><G><R><L><G><P><S><D><Y><F><G><E><I><A><L><L><L><N><R><P><R><A><A><T><V><V><A><R><G><P><L><K><C><V><K><L><D><R><P><R><F><E><R><V><L><G><P><C><S><E><I><L><K><R><N><I><Q><R><Y><N><S><F><I><S><L><T><V>
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.<BOP>
P31321
Q86XJ1
GA2L3_HUMAN
Growth arrest-specific protein 2-like 3
Homo
<M><Q><P><A><I><Q><V><W><F><G><E><D><L><P><L><S><P><R><S><P><L><T><P><R><H><G><P><G><L><A><N><V><C><Q><Y><D><E><W><I><A><V><R><H><E><A><T><L><L><P><M><Q><E><D><L><S><I><W><L><S><G><L><L><G><I><K><V><K><A><E><K><L><L><E><E><L><D><N><G><V><L><L><C><Q><L><I><D><V><L><Q><N><M><V><K><T><C><N><S><E><E><S><G><N><F><P><M><R><K><V><P><C><K><K><D><A><A><S><G><S><F><F><A><R><D><N><T><A><N><F><L><H><W><C><R><D><I><G><V><D><E><T><Y><L><F><E><S><E><G><L><V><L><H><K><D><P><R><Q><V><Y><L><C><L><L><E><I><G><R><I><V><S><R><Y><G><V><E><P><P><V><L><V><K><L><E><K><E><I><E><L><E><E><T><L><L><N><T><S><G><P><E><D><S><I><S><I><P><K><S><C><C><R><H><E><E><L><H><E><A><V><K><H><I><A><E><D><P><P><C><S><C><S><H><R><F><S><I><E><Y><L><S><E><G><R><Y><R><L><G><D><K><I><L><F><I><R><M><L><H><G><K><H><V><M><V><R><V><G><G><G><W><D><T><L><Q><G><F><L><L><K><Y><D><P><C><R><I><L><Q><F><A><T><L><E><Q><K><I><L><A><F><Q><K><G><V><S><N><E><S><V><P><D><S><P><A><R><T><P><Q><P><P><E><M><N><P><L><S><A><V><N><M><F><Q><K><Q><N><S><K><P><S><V><P><V><S><I><P><K><S><K><E><K><Q><G><R><P><P><G><A><L><V><P><A><S><S><L><K><G><G><N><L><G><S><M><S><V><R><S><K><L><P><N><S><P><A><A><S><S><H><P><K><L><K><S><S><K><G><I><T><K><K><P><Q><A><P><S><N><N><A><S><S><S><L><A><S><L><N><P><V><G><K><N><T><S><S><P><A><L><P><R><T><A><P><C><I><S><E><S><P><R><K><C><I><S><S><P><N><T><P><K><A><K><V><I><P><A><Q><N><S><A><D><L><P><E><S><T><L><L><P><N><K><C><S><G><K><T><Q><P><K><Y><L><K><H><N><H><I><S><S><R><D><N><A><V><S><H><L><A><A><H><S><N><S><S><S><K><C><P><K><L><P><K><A><N><I><P><V><R><P><K><P><S><F><Q><S><S><A><K><M><T><K><T><S><S><K><T><I><A><T><G><L><G><T><Q><S><Q><P><S><D><G><A><P><Q><A><K><P><V><P><A><Q><K><L><K><S><A><L><N><L><N><Q><P><V><S><V><S><S><V><S><P><V><K><A><T><Q><K><S><K><D><K><N><I><V><S><A><T><K><K><Q><P><Q><N><K><S><A><F><Q><K><T><G><P><S><S><L><K><S><P><G><R><T><P><L><S><I><V><S><L><P><Q><S><S><T><K><T><Q><T><A><P><K><S><A><Q><T><V><A><K><S><Q><H><S><T><K><G><P><P><R><S><G><K><T><P><A><S><I><R><K><P><P><S><S><V><K><D><A><D><S><G><D><K><K><P><T><A><K><K><K><E><D><D><D><H><Y><F><V><M><T><G><S><K><K><P><R><K>
Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network.<BOP>
Q86XJ1
Q9H3L0
MMAD_HUMAN
Methylmalonic aciduria and homocystinuria type D protein, mitochondrial
Homo
<M><A><N><V><L><C><N><R><A><R><L><V><S><Y><L><P><G><F><C><S><L><V><K><R><V><V><N><P><K><A><F><S><T><A><G><S><S><G><S><D><E><S><H><V><A><A><A><P><P><D><I><C><S><R><T><V><W><P><D><E><T><M><G><P><F><G><P><Q><D><Q><R><F><Q><L><P><G><N><I><G><F><D><C><H><L><N><G><T><A><S><Q><K><K><S><L><V><H><K><T><L><P><D><V><L><A><E><P><L><S><S><E><R><H><E><F><V><M><A><Q><Y><V><N><E><F><Q><G><N><D><A><P><V><E><Q><E><I><N><S><A><E><T><Y><F><E><S><A><R><V><E><C><A><I><Q><T><C><P><E><L><L><R><K><D><F><E><S><L><F><P><E><V><A><N><G><K><L><M><I><L><T><V><T><Q><K><T><K><N><D><M><T><V><W><S><E><E><V><E><I><E><R><E><V><L><L><E><K><F><I><N><G><A><K><E><I><C><Y><A><L><R><A><E><G><Y><W><A><D><F><I><D><P><S><S><G><L><A><F><F><G><P><Y><T><N><N><T><L><F><E><T><D><E><R><Y><R><H><L><G><F><S><V><D><D><L><G><C><C><K><V><I><R><H><S><L><W><G><T><H><V><V><V><G><S><I><F><T><N><A><T><P><D><S><H><I><M><K><K><L><S><G><N>
Involved in cobalamin metabolism and trafficking . Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) . Promotes oxidation of cob(II)alamin bound to MMACHC . The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine .<BOP>
Q9H3L0
P0C870
JMJD7_HUMAN
L-lysine (3S)-hydroxylase JMJD7
Homo
<M><A><E><A><A><L><E><A><V><R><S><E><L><R><E><F><P><A><A><A><R><E><L><C><V><P><L><A><V><P><Y><L><D><K><P><P><T><P><L><H><F><Y><R><D><W><V><C><P><N><R><P><C><I><I><R><N><A><L><Q><H><W><P><A><L><Q><K><W><S><L><P><Y><F><R><A><T><V><G><S><T><E><V><S><V><A><V><T><P><D><G><Y><A><D><A><V><R><G><D><R><F><M><M><P><A><E><R><R><L><P><L><S><F><V><L><D><V><L><E><G><R><A><Q><H><P><G><V><L><Y><V><Q><K><Q><C><S><N><L><P><S><E><L><P><Q><L><L><P><D><L><E><S><H><V><P><W><A><S><E><A><L><G><K><M><P><D><A><V><N><F><W><L><G><E><A><A><A><V><T><S><L><H><K><D><H><Y><E><N><L><Y><C><V><V><S><G><E><K><H><F><L><F><H><P><P><S><D><R><P><F><I><P><Y><E><L><Y><T><P><A><T><Y><Q><L><T><E><E><G><T><F><K><V><V><D><E><E><A><M><E><K><V><P><W><I><P><L><D><P><L><A><P><D><L><A><R><Y><P><S><Y><S><Q><A><Q><A><L><R><C><T><V><R><A><G><E><M><L><Y><L><P><A><L><W><F><H><H><V><Q><Q><S><Q><G><C><I><A><V><N><F><W><Y><D><M><E><Y><D><L><K><Y><S><Y><F><Q><L><L><D><S><L><T><K><A><S><G><L><D>
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase . Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation . Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 . After initial cleavage, continues to digest histones tails via its aminopeptidase activity . Additionally, may play a role in protein biosynthesis by modifying the translation machinery . Acts as Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) .<BOP>
P0C870
Q8NHC6
O14L1_HUMAN
Putative olfactory receptor 5AV1
Homo
<M><S><P><D><T><F><L><K><G><F><A><E><F><F><L><M><G><F><S><N><S><W><D><I><Q><I><V><H><A><A><L><F><F><L><V><Y><L><A><A><V><I><G><N><L><L><I><I><I><L><T><T><L><D><V><H><L><Q><T><P><M><Y><F><F><L><R><N><L><S><F><L><D><F><C><Y><I><S><V><T><I><P><K><S><I><V><S><S><L><T><H><D><T><S><I><S><F><F><G><C><A><L><Q><A><F><F><F><M><D><L><A><T><T><E><V><A><I><L><T><V><M><S><Y><D><R><Y><M><A><I><C><R><P><L><H><Y><E><V><I><I><N><Q><G><V><C><L><R><M><M><A><M><S><W><L><S><G><V><I><C><G><F><M><H><V><I><A><T><F><S><L><P><F><C><G><R><N><R><I><R><Q><F><F><C><N><I><P><Q><L><L><S><L><L><D><P><K><V><I><T><I><E><I><G><V><M><V><F><G><T><S><L><V><I><I><S><F><V><V><I><T><L><S><Y><M><Y><I><F><S><V><I><M><R><I><P><S><K><E><G><R><S><K><T><F><S><T><C><I><P><H><L><V><V><V><T><L><F><M><I><S><G><S><I><A><Y><V><K><P><I><S><N><S><P><P><V><L><D><V><F><L><S><A><F><Y><T><V><V><P><P><T><L><N><P><V><I><Y><S><L><R><N><R><D><M><K><A><A><L><R><R><Q><C><G><P>
Odorant receptor.<BOP>
Q8NHC6
Q9UIM3
FKBPL_HUMAN
WAF-1/CIP1 stabilizing protein 39
Homo
<M><E><T><P><P><V><N><T><I><G><E><K><D><T><S><Q><P><Q><Q><E><W><E><K><N><L><R><E><N><L><D><S><V><I><Q><I><R><Q><Q><P><R><D><P><P><T><E><T><L><E><L><E><V><S><P><D><P><A><S><Q><I><L><E><H><T><Q><G><A><E><K><L><V><A><E><L><E><G><D><S><H><K><S><H><G><S><T><S><Q><M><P><E><A><L><Q><A><S><D><L><W><Y><C><P><D><G><S><F><V><K><K><I><V><I><R><G><H><G><L><D><K><P><K><L><G><S><C><C><R><V><L><A><L><G><F><P><F><G><S><G><P><P><E><G><W><T><E><L><T><M><G><V><G><P><W><R><E><E><T><W><G><E><L><I><E><K><C><L><E><S><M><C><Q><G><E><E><A><E><L><Q><L><P><G><H><S><G><P><P><V><R><L><T><L><A><S><F><T><Q><G><R><D><S><W><E><L><E><T><S><E><K><E><A><L><A><R><E><E><R><A><R><G><T><E><L><F><R><A><G><N><P><E><G><A><A><R><C><Y><G><R><A><L><R><L><L><L><T><L><P><P><P><G><P><P><E><R><T><V><L><H><A><N><L><A><A><C><Q><L><L><L><G><Q><P><Q><L><A><A><Q><S><C><D><R><V><L><E><R><E><P><G><H><L><K><A><L><Y><R><R><G><V><A><Q><A><A><L><G><N><L><E><K><A><T><A><D><L><K><K><V><L><A><I><D><P><K><N><R><A><A><Q><E><E><L><G><K><V><V><I><Q><G><K><N><Q><D><A><G><L><A><Q><G><L><R><K><M><F><G>
May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.<BOP>
Q9UIM3
Q6IFN5
O7E24_HUMAN
Olfactory receptor OR19-14
Homo
<M><S><Y><F><P><I><L><F><F><F><F><L><K><R><C><P><S><Y><T><E><P><Q><N><L><T><G><V><S><E><F><L><L><L><G><L><S><E><D><P><E><L><Q><P><V><L><A><G><L><F><L><S><M><Y><L><V><T><V><L><G><N><L><L><I><I><L><A><V><S><S><D><S><H><L><H><T><P><M><Y><F><F><L><S><N><L><S><L><A><D><I><G><F><T><S><T><T><V><P><K><M><I><V><D><M><Q><T><H><S><R><V><I><S><Y><E><G><C><L><T><Q><M><S><F><F><V><L><F><A><C><M><D><D><M><L><L><S><V><M><A><Y><D><R><F><V><A><I><C><H><P><L><H><Y><R><I><I><M><N><P><R><L><C><G><F><L><I><L><L><S><F><F><I><S><L><L><D><S><Q><L><H><N><L><I><M><L><Q><L><T><C><F><K><D><V><D><I><S><N><F><F><C><D><P><S><Q><L><L><H><L><R><C><S><D><T><F><I><N><E><M><V><I><Y><F><M><G><A><I><F><G><C><L><P><I><S><G><I><L><F><S><Y><Y><K><I><V><S><P><I><L><R><V><P><T><S><D><G><K><Y><K><A><F><S><T><C><G><S><H><L><A><V><V><C><L><F><Y><G><T><G><L><V><G><Y><L><S><S><A><V><L><P><S><P><R><K><S><M><V><A><S><V><M><Y><T><V><V><T><P><M><L><N><P><F><I><Y><S><L><R><N><K><D><I><Q><S><A><L><C><R><L><H><G><R><I><I><K><S><H><H><L><H><P><F><C><Y><M><G>
Odorant receptor.<BOP>
Q6IFN5
P04731
MT1A_HUMAN
Metallothionein-IA
Homo
<M><D><P><N><C><S><C><A><T><G><G><S><C><T><C><T><G><S><C><K><C><K><E><C><K><C><T><S><C><K><K><S><C><C><S><C><C><P><M><S><C><A><K><C><A><Q><G><C><I><C><K><G><A><S><E><K><C><S><C><C><A>
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.<BOP>
P04731
O95214
LERL1_HUMAN
Endospanin-2
Homo
<M><A><G><I><K><A><L><I><S><L><S><F><G><G><A><I><G><L><M><F><L><M><L><G><C><A><L><P><I><Y><N><K><Y><W><P><L><F><V><L><F><F><Y><I><L><S><P><I><P><Y><C><I><A><R><R><L><V><D><D><T><D><A><M><S><N><A><C><K><E><L><A><I><F><L><T><T><G><I><V><V><S><A><F><G><L><P><I><V><F><A><R><A><H><L><I><E><W><G><A><C><A><L><V><L><T><G><N><T><V><I><F><A><T><I><L><G><F><F><L><V><F><G><S><N><D><D><F><S><W><Q><Q><W>
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.<BOP>
O95214
Q5VWC8
HACD4_HUMAN
Protein-tyrosine phosphatase-like A domain-containing protein 2
Homo
<M><G><P><L><A><L><P><A><W><L><Q><P><R><Y><R><K><N><A><Y><L><F><I><Y><Y><L><I><Q><F><C><G><H><S><W><I><F><T><N><M><T><V><R><F><F><S><F><G><K><D><S><M><V><D><T><F><Y><A><I><G><L><V><M><R><L><C><Q><S><V><S><L><L><E><L><L><H><I><Y><V><G><I><E><S><N><H><L><L><P><R><F><L><Q><L><T><E><R><I><I><I><L><F><V><V><I><T><S><Q><E><E><V><Q><E><K><Y><V><V><C><V><L><F><V><F><W><N><L><L><D><M><V><R><Y><T><Y><S><M><L><S><V><I><G><I><S><Y><A><V><L><T><W><L><S><Q><T><L><W><M><P><I><Y><P><L><C><V><L><A><E><A><F><A><I><Y><Q><S><L><P><Y><F><E><S><F><G><T><Y><S><T><K><L><P><F><D><L><S><I><Y><F><P><Y><V><L><K><I><Y><L><M><M><L><F><I><G><M><Y><F><T><Y><S><H><L><Y><S><E><R><R><D><I><L><G><I><F><P><I><K><K><K><K><M>
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.<BOP>
Q5VWC8
Q9NUK0
MBNL3_HUMAN
Protein HCHCR
Homo
<M><T><A><V><N><V><A><L><I><R><D><T><K><W><L><T><L><E><V><C><R><E><F><Q><R><G><T><C><S><R><A><D><A><D><C><K><F><A><H><P><P><R><V><C><H><V><E><N><G><R><V><V><A><C><F><D><S><L><K><G><R><C><T><R><E><N><C><K><Y><L><H><P><P><P><H><L><K><T><Q><L><E><I><N><G><R><N><N><L><I><Q><Q><K><T><A><A><A><M><F><A><Q><Q><M><Q><L><M><L><Q><N><A><Q><M><S><S><L><G><S><F><P><M><T><P><S><I><P><A><N><P><P><M><A><F><N><P><Y><I><P><H><P><G><M><G><L><V><P><A><E><L><V><P><N><T><P><V><L><I><P><G><N><P><P><L><A><M><P><G><A><V><G><P><K><L><M><R><S><D><K><L><E><V><C><R><E><F><Q><R><G><N><C><T><R><G><E><N><D><C><R><Y><A><H><P><T><D><A><S><M><I><E><A><S><D><N><T><V><T><I><C><M><D><Y><I><K><G><R><C><S><R><E><K><C><K><Y><F><H><P><P><A><H><L><Q><A><R><L><K><A><A><H><H><Q><M><N><H><S><A><A><S><A><M><A><L><Q><P><G><T><L><Q><L><I><P><K><R><S><A><L><E><K><P><N><G><A><T><P><V><F><N><P><T><V><F><H><C><Q><Q><A><L><T><N><L><Q><L><P><Q><P><A><F><I><P><A><G><P><I><L><C><M><A><P><A><S><N><I><V><P><M><M><H><G><A><T><P><T><T><V><S><A><A><T><T><P><A><T><S><V><P><F><A><A><P><T><T><G><N><Q><L><K><F>
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.<BOP>
Q9NUK0
O95393
BMP10_HUMAN
Bone morphogenetic protein 10
Homo
<M><G><S><L><V><L><T><L><C><A><L><F><C><L><A><A><Y><L><V><S><G><S><P><I><M><N><L><E><Q><S><P><L><E><E><D><M><S><L><F><G><D><V><F><S><E><Q><D><G><V><D><F><N><T><L><L><Q><S><M><K><D><E><F><L><K><T><L><N><L><S><D><I><P><T><Q><D><S><A><K><V><D><P><P><E><Y><M><L><E><L><Y><N><K><F><A><T><D><R><T><S><M><P><S><A><N><I><I><R><S><F><K><N><E><D><L><F><S><Q><P><V><S><F><N><G><L><R><K><Y><P><L><L><F><N><V><S><I><P><H><H><E><E><V><I><M><A><E><L><R><L><Y><T><L><V><Q><R><D><R><M><I><Y><D><G><V><D><R><K><I><T><I><F><E><V><L><E><S><K><G><D><N><E><G><E><R><N><M><L><V><L><V><S><G><E><I><Y><G><T><N><S><E><W><E><T><F><D><V><T><D><A><I><R><R><W><Q><K><S><G><S><S><T><H><Q><L><E><V><H><I><E><S><K><H><D><E><A><E><D><A><S><S><G><R><L><E><I><D><T><S><A><Q><N><K><H><N><P><L><L><I><V><F><S><D><D><Q><S><S><D><K><E><R><K><E><E><L><N><E><M><I><S><H><E><Q><L><P><E><L><D><N><L><G><L><D><S><F><S><S><G><P><G><E><E><A><L><L><Q><M><R><S><N><I><I><Y><D><S><T><A><R><I><R><R><N><A><K><G><N><Y><C><K><R><T><P><L><Y><I><D><F><K><E><I><G><W><D><S><W><I><I><A><P><P><G><Y><E><A><Y><E><C><R><G><V><C><N><Y><P><L><A><E><H><L><T><P><T><K><H><A><I><I><Q><A><L><V><H><L><K><N><S><Q><K><A><S><K><A><C><C><V><P><T><K><L><E><P><I><S><I><L><Y><L><D><K><G><V><V><T><Y><K><F><K><Y><E><G><M><A><V><S><E><C><G><C><R>
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.<BOP>
O95393
Q06710
PAX8_HUMAN
Paired box protein Pax-8
Homo
<M><P><H><N><S><I><R><S><G><H><G><G><L><N><Q><L><G><G><A><F><V><N><G><R><P><L><P><E><V><V><R><Q><R><I><V><D><L><A><H><Q><G><V><R><P><C><D><I><S><R><Q><L><R><V><S><H><G><C><V><S><K><I><L><G><R><Y><Y><E><T><G><S><I><R><P><G><V><I><G><G><S><K><P><K><V><A><T><P><K><V><V><E><K><I><G><D><Y><K><R><Q><N><P><T><M><F><A><W><E><I><R><D><R><L><L><A><E><G><V><C><D><N><D><T><V><P><S><V><S><S><I><N><R><I><I><R><T><K><V><Q><Q><P><F><N><L><P><M><D><S><C><V><A><T><K><S><L><S><P><G><H><T><L><I><P><S><S><A><V><T><P><P><E><S><P><Q><S><D><S><L><G><S><T><Y><S><I><N><G><L><L><G><I><A><Q><P><G><S><D><K><R><K><M><D><D><S><D><Q><D><S><C><R><L><S><I><D><S><Q><S><S><S><S><G><P><R><K><H><L><R><T><D><A><F><S><Q><H><H><L><E><P><L><E><C><P><F><E><R><Q><H><Y><P><E><A><Y><A><S><P><S><H><T><K><G><E><Q><G><L><Y><P><L><P><L><L><N><S><T><L><D><D><G><K><A><T><L><T><P><S><N><T><P><L><G><R><N><L><S><T><H><Q><T><Y><P><V><V><A><D><P><H><S><P><F><A><I><K><Q><E><T><P><E><V><S><S><S><S><S><T><P><S><S><L><S><S><S><A><F><L><D><L><Q><Q><V><G><S><G><V><P><P><F><N><A><F><P><H><A><A><S><V><Y><G><Q><F><T><G><Q><A><L><L><S><G><R><E><M><V><G><P><T><L><P><G><Y><P><P><H><I><P><T><S><G><Q><G><S><Y><A><S><S><A><I><A><G><M><V><A><G><S><E><Y><S><G><N><A><Y><G><H><T><P><Y><S><S><Y><S><E><A><W><R><F><P><N><S><S><L><L><S><S><P><Y><Y><Y><S><S><T><S><R><P><S><A><P><P><T><T><A><T><A><F><D><H><L>
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.<BOP>
Q06710
Q9UHA7
IL36A_HUMAN
Interleukin-1 family member 6
Homo
<M><E><K><A><L><K><I><D><T><P><Q><Q><G><S><I><Q><D><I><N><H><R><V><W><V><L><Q><D><Q><T><L><I><A><V><P><R><K><D><R><M><S><P><V><T><I><A><L><I><S><C><R><H><V><E><T><L><E><K><D><R><G><N><P><I><Y><L><G><L><N><G><L><N><L><C><L><M><C><A><K><V><G><D><Q><P><T><L><Q><L><K><E><K><D><I><M><D><L><Y><N><Q><P><E><P><V><K><S><F><L><F><Y><H><S><Q><S><G><R><N><S><T><F><E><S><V><A><F><P><G><W><F><I><A><V><S><S><E><G><G><C><P><L><I><L><T><Q><E><L><G><K><A><N><T><T><D><F><G><L><T><M><L><F>
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL
Q9UHA7
Q10586
DBP_HUMAN
Tax-responsive enhancer element-binding protein 302
Homo
<M><A><R><P><V><S><D><R><T><P><A><P><L><L><L><G><G><P><A><G><T><P><P><G><G><G><A><L><L><G><L><R><S><L><L><Q><G><T><S><K><P><K><E><P><A><S><C><L><L><K><E><K><E><R><K><A><A><L><P><A><A><T><T><P><G><P><G><L><E><T><A><G><P><A><D><A><P><A><G><A><V><V><G><G><G><S><P><R><G><R><P><G><P><V><P><A><P><G><L><L><A><P><L><L><W><E><R><T><L><P><F><G><D><V><E><Y><V><D><L><D><A><F><L><L><E><H><G><L><P><P><S><P><P><P><P><G><G><P><S><P><E><P><S><P><A><R><T><P><A><P><S><P><G><P><G><S><C><G><S><A><S><P><R><S><S><P><G><H><A><P><A><R><A><A><L><G><T><A><S><G><H><R><A><G><L><T><S><R><D><T><P><S><P><V><D><P><D><T><V><E><V><L><M><T><F><E><P><D><P><A><D><L><A><L><S><S><I><P><G><H><E><T><F><D><P><R><R><H><R><F><S><E><E><E><L><K><P><Q><P><I><M><K><K><A><R><K><I><Q><V><P><E><E><Q><K><D><E><K><Y><W><S><R><R><Y><K><N><N><E><A><A><K><R><S><R><D><A><R><R><L><K><E><N><Q><I><S><V><R><A><A><F><L><E><K><E><N><A><L><L><R><Q><E><V><V><A><V><R><Q><E><L><S><H><Y><R><A><V><L><S><R><Y><Q><A><Q><H><G><A><L>
This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.<BOP>
Q10586
P29966
MARCS_HUMAN
Protein kinase C substrate, 80 kDa protein, light chain
Homo
<M><G><A><Q><F><S><K><T><A><A><K><G><E><A><A><A><E><R><P><G><E><A><A><V><A><S><S><P><S><K><A><N><G><Q><E><N><G><H><V><K><V><N><G><D><A><S><P><A><A><A><E><S><G><A><K><E><E><L><Q><A><N><G><S><A><P><A><A><D><K><E><E><P><A><A><A><G><S><G><A><A><S><P><S><A><A><E><K><G><E><P><A><A><A><A><A><P><E><A><G><A><S><P><V><E><K><E><A><P><A><E><G><E><A><A><E><P><G><S><P><T><A><A><E><G><E><A><A><S><A><A><S><S><T><S><S><P><K><A><E><D><G><A><T><P><S><P><S><N><E><T><P><K><K><K><K><K><R><F><S><F><K><K><S><F><K><L><S><G><F><S><F><K><K><N><K><K><E><A><G><E><G><G><E><A><E><A><P><A><A><E><G><G><K><D><E><A><A><G><G><A><A><A><A><A><A><E><A><G><A><A><S><G><E><Q><A><A><A><P><G><E><E><A><A><A><G><E><E><G><A><A><G><G><D><P><Q><E><A><K><P><Q><E><A><A><V><A><P><E><K><P><P><A><S><D><E><T><K><A><A><E><E><P><S><K><V><E><E><K><K><A><E><E><A><G><A><S><A><A><A><C><E><A><P><S><A><A><G><P><G><A><P><P><E><Q><E><A><A><P><A><E><E><P><A><A><A><A><A><S><S><A><C><A><A><P><S><Q><E><A><Q><P><E><C><S><P><E><A><P><P><A><E><A><A><E>
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.<BOP>
P29966
P15621
ZNF44_HUMAN
Zinc finger protein KOX7
Homo
<M><A><L><C><Y><G><T><F><W><G><Y><P><K><M><L><E><A><A><N><L><M><E><G><L><V><D><I><G><P><W><V><T><L><P><R><G><Q><P><E><V><L><E><W><G><L><P><K><D><Q><D><S><V><A><F><E><D><V><A><V><N><F><T><H><E><E><W><A><L><L><G><P><S><Q><K><N><L><Y><R><D><V><M><R><E><T><I><R><N><L><N><C><I><G><M><K><W><E><N><Q><N><I><D><D><Q><H><Q><N><L><R><R><N><P><R><C><D><V><V><E><R><F><G><K><S><K><D><G><S><Q><C><G><E><T><L><S><Q><I><R><N><S><I><V><N><K><N><T><P><A><R><V><D><A><C><G><S><S><V><N><G><E><V><I><M><G><H><S><S><L><N><C><Y><I><R><V><D><T><G><H><K><H><R><E><C><H><E><Y><A><E><K><S><Y><T><H><K><Q><C><G><K><G><L><S><Y><R><H><S><F><Q><T><C><E><R><P><H><T><G><K><K><P><Y><D><C><K><E><C><G><K><T><F><S><S><P><G><N><L><R><R><H><M><V><V><K><G><G><D><G><P><Y><K><C><E><L><C><G><K><A><F><F><W><P><S><L><L><R><M><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><S><K><A><F><P><V><Y><S><S><Y><L><R><H><E><K><I><H><T><G><E><K><P><Y><E><C><K><Q><C><S><K><A><F><P><D><Y><S><S><Y><L><R><H><E><R><T><H><T><G><E><K><P><Y><K><C><K><Q><C><G><K><A><F><S><V><S><G><S><L><R><V><H><E><R><I><H><T><G><E><K><P><Y><T><C><K><Q><C><G><K><A><F><C><H><L><G><S><F><Q><R><H><M><I><M><H><S><G><D><G><P><H><K><C><K><I><C><G><K><G><F><D><F><P><G><S><A><R><I><H><E><G><T><H><T><L><E><K><P><Y><E><C><K><Q><C><G><K><L><L><S><H><R><S><S><F><R><R><H><M><M><A><H><T><G><D><G><P><H><K><C><T><V><C><G><K><A><F><D><S><P><S><V><F><Q><R><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><T><S><S><S><L><R><K><H><E><T><T><H><T><G><E><Q><P><Y><K><C><K><C><G><K><A><F><S><D><L><F><S><F><Q><S><H><E><T><T><H><S><E><E><E><P><Y><E><C><K><E><C><G><K><A><F><S><S><F><K><Y><F><C><R><H><E><R><T><H><S><E><E><K><S><Y><E><C><Q><I><C><G><K><A><F><S><R><F><S><Y><L><K><T><H><E><R><T><H><T><A><E><K><P><Y><E><C><K><Q><C><R><K><A><F><F><W><P><S><F><L><L><R><H><E><R><T><H><T><G><E><R><P><Y><E><C><K><H><C><G><K><A><F><S><R><S><S><F><C><R><E><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><S><L><S><S><F><N><R><H><K><R><T><H><W><K><D><I><L>
May be involved in transcriptional regulation.<BOP>
P15621
P09629
HXB7_HUMAN
Homeobox protein Hox-2C
Homo
<M><S><S><L><Y><Y><A><N><T><L><F><S><K><Y><P><A><S><S><S><V><F><A><T><G><A><F><P><E><Q><T><S><C><A><F><A><S><N><P><Q><R><P><G><Y><G><A><G><S><G><A><S><F><A><A><S><M><Q><G><L><Y><P><G><G><G><G><M><A><G><Q><S><A><A><G><V><Y><A><A><G><Y><G><L><E><P><S><S><F><N><M><H><C><A><P><F><E><Q><N><L><S><G><V><C><P><G><D><S><A><K><A><A><G><A><K><E><Q><R><D><S><D><L><A><A><E><S><N><F><R><I><Y><P><W><M><R><S><S><G><T><D><R><K><R><G><R><Q><T><Y><T><R><Y><Q><T><L><E><L><E><K><E><F><H><Y><N><R><Y><L><T><R><R><R><R><I><E><I><A><H><T><L><C><L><T><E><R><Q><I><K><I><W><F><Q><N><R><R><M><K><W><K><K><E><N><K><T><A><G><P><G><T><T><G><Q><D><R><A><E><A><E><E><E><E><E><E>
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP>
P09629
P32745
SSR3_HUMAN
SSR-28
Homo
<M><D><M><L><H><P><S><S><V><S><T><T><S><E><P><E><N><A><S><S><A><W><P><P><D><A><T><L><G><N><V><S><A><G><P><S><P><A><G><L><A><V><S><G><V><L><I><P><L><V><Y><L><V><V><C><V><V><G><L><L><G><N><S><L><V><I><Y><V><V><L><R><H><T><A><S><P><S><V><T><N><V><Y><I><L><N><L><A><L><A><D><E><L><F><M><L><G><L><P><F><L><A><A><Q><N><A><L><S><Y><W><P><F><G><S><L><M><C><R><L><V><M><A><V><D><G><I><N><Q><F><T><S><I><F><C><L><T><V><M><S><V><D><R><Y><L><A><V><V><H><P><T><R><S><A><R><W><R><T><A><P><V><A><R><T><V><S><A><A><V><W><V><A><S><A><V><V><V><L><P><V><V><V><F><S><G><V><P><R><G><M><S><T><C><H><M><Q><W><P><E><P><A><A><A><W><R><A><G><F><I><I><Y><T><A><A><L><G><F><F><G><P><L><L><V><I><C><L><C><Y><L><L><I><V><V><K><V><R><S><A><G><R><R><V><W><A><P><S><C><Q><R><R><R><R><S><E><R><R><V><T><R><M><V><V><A><V><V><A><L><F><V><L><C><W><M><P><F><Y><V><L><N><I><V><N><V><V><C><P><L><P><E><E><P><A><F><F><G><L><Y><F><L><V><V><A><L><P><Y><A><N><S><C><A><N><P><I><L><Y><G><F><L><S><Y><R><F><K><Q><G><F><R><R><V><L><L><R><P><S><R><R><V><R><S><Q><E><P><T><V><G><P><P><E><K><T><E><E><E><D><E><E><E><E><D><G><E><E><S><R><E><G><G><K><G><K><E><M><N><G><R><V><S><Q><I><T><Q><P><G><T><S><G><Q><E><R><P><P><S><R><V><A><S><K><E><Q><Q><L><L><P><Q><E><A><S><T><G><E><K><S><S><T><M><R><I><S><Y><L>
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.<BOP>
P32745
P50991
TCPD_HUMAN
Stimulator of TAR RNA-binding
Homo
<M><P><E><N><V><A><P><R><S><G><A><T><A><G><A><A><G><G><R><G><K><G><A><Y><Q><D><R><D><K><P><A><Q><I><R><F><S><N><I><S><A><A><K><A><V><A><D><A><I><R><T><S><L><G><P><K><G><M><D><K><M><I><Q><D><G><K><G><D><V><T><I><T><N><D><G><A><T><I><L><K><Q><M><Q><V><L><H><P><A><A><R><M><L><V><E><L><S><K><A><Q><D><I><E><A><G><D><G><T><T><S><V><V><I><I><A><G><S><L><L><D><S><C><T><K><L><L><Q><K><G><I><H><P><T><I><I><S><E><S><F><Q><K><A><L><E><K><G><I><E><I><L><T><D><M><S><R><P><V><E><L><S><D><R><E><T><L><L><N><S><A><T><T><S><L><N><S><K><V><V><S><Q><Y><S><S><L><L><S><P><M><S><V><N><A><V><M><K><V><I><D><P><A><T><A><T><S><V><D><L><R><D><I><K><I><V><K><K><L><G><G><T><I><D><D><C><E><L><V><E><G><L><V><L><T><Q><K><V><S><N><S><G><I><T><R><V><E><K><A><K><I><G><L><I><Q><F><C><L><S><A><P><K><T><D><M><D><N><Q><I><V><V><S><D><Y><A><Q><M><D><R><V><L><R><E><E><R><A><Y><I><L><N><L><V><K><Q><I><K><K><T><G><C><N><V><L><L><I><Q><K><S><I><L><R><D><A><L><S><D><L><A><L><H><F><L><N><K><M><K><I><M><V><I><K><D><I><E><R><E><D><I><E><F><I><C><K><T><I><G><T><K><P><V><A><H><I><D><Q><F><T><A><D><M><L><G><S><A><E><L><A><E><E><V><N><L><N><G><S><G><K><L><L><K><I><T><G><C><A><S><P><G><K><T><V><T><I><V><V><R><G><S><N><K><L><V><I><E><E><A><E><R><S><I><H><D><A><L><C><V><I><R><C><L><V><K><K><R><A><L><I><A><G><G><G><A><P><E><I><E><L><A><L><R><L><T><E><Y><S><R><T><L><S><G><M><E><S><Y><C><V><R><A><F><A><D><A><M><E><V><I><P><S><T><L><A><E><N><A><G><L><N><P><I><S><T><V><T><E><L><R><N><R><H><A><Q><G><E><K><T><A><G><I><N><V><R><K><G><G><I><S><N><I><L><E><E><L><V><V><Q><P><L><L><V><S><V><S><A><L><T><L><A><T><E><T><V><R><S><I><L><K><I><D><D><V><V><N><T><R>
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis . The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance . As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . The TRiC complex plays a role in the folding of actin and tubulin (Probable).<BOP>
P50991
Q14188
TFDP2_HUMAN
E2F dimerization partner 2
Homo
<M><T><A><K><N><V><G><L><T><S><T><N><A><E><V><R><G><F><I><D><Q><N><L><S><P><T><K><G><N><I><S><F><V><A><F><P><V><S><N><T><N><S><P><T><K><I><L><P><K><T><L><G><P><I><N><V><N><V><G><P><Q><M><I><I><S><T><P><Q><R><L><T><S><S><G><S><V><L><I><G><S><P><Y><T><P><A><P><A><M><V><T><Q><T><H><I><A><E><A><T><G><W><V><P><G><D><R><K><R><A><R><K><F><I><D><S><D><F><S><E><S><K><R><S><K><K><G><D><K><N><G><K><G><L><R><H><F><S><M><K><V><C><E><K><V><Q><R><K><G><T><T><S><Y><N><E><V><A><D><E><L><V><S><E><F><T><N><S><N><N><H><L><A><A><D><S><A><Y><D><Q><K><N><I><R><R><R><V><Y><D><A><L><N><V><L><M><A><M><N><I><I><S><K><E><K><K><E><I><K><W><I><G><L><P><T><N><S><A><Q><E><C><Q><N><L><E><I><E><K><Q><R><R><I><E><R><I><K><Q><K><R><A><Q><L><Q><E><L><L><L><Q><Q><I><A><F><K><N><L><V><Q><R><N><R><Q><N><E><Q><Q><N><Q><G><P><P><A><L><N><S><T><I><Q><L><P><F><I><I><I><N><T><S><R><K><T><V><I><D><C><S><I><S><S><D><K><F><E><Y><L><F><N><F><D><N><T><F><E><I><H><D><D><I><E><V><L><K><R><M><G><M><S><F><G><L><E><S><G><K><C><S><L><E><D><L><K><L><A><K><S><L><V><P><K><A><L><E><G><Y><I><T><D><I><S><T><G><P><S><W><L><N><Q><G><L><L><L><N><S><T><Q><S><V><S><N><L><D><L><T><T><G><A><T><L><P><Q><S><S><V><N><Q><G><L><C><L><D><A><E><V><A><L><A><T><G><Q><F><L><A><P><N><S><H><Q><S><S><S><A><A><S><H><C><S><E><S><R><G><E><T><P><C><S><F><N><D><E><D><E><E><D><D><E><E><D><S><S><S><P><E>
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters .<BOP>
Q14188
Q3MIW9
MUCL3_HUMAN
Diffuse panbronchiolitis critical region protein 1
Homo
<M><A><Q><P><V><H><S><L><C><S><A><F><G><L><Q><C><C><L><L><F><L><L><A><S><W><G><A><G><A><T><T><F><Q><E><Y><Q><K><T><G><E><L><S><T><S><D><H><I><F><P><L><T><P><G><L><V><Y><S><I><P><F><D><H><I><V><L><H><S><G><Q><R><P><P><E><L><P><K><S><T><E><I><H><E><Q><K><R><H><C><N><T><T><R><H><S><K><P><T><D><K><P><T><G><N><S><K><T><I><D><H><K><S><S><T><D><N><H><E><A><P><P><T><S><E><E><N><S><S><N><Q><G><K><D><P><M><I><R><N><Q><R><S><V><D><P><A><D><S><T><T><T><H><K><E><S><A><G><K><K><H><I><T><P><A><P><K><S><K><I><N><C><R><K><S><T><T><G><K><S><T><V><T><R><K><S><D><K><T><G><R><P><L><E><K><S><M><S><T><L><D><K><T><S><T><S><S><H><K><T><T><T><S><F><H><N><S><G><N><S><Q><T><K><Q><K><S><T><S><F><P><E><K><I><T><A><A><S><K><T><T><Y><K><T><T><G><T><P><E><E><S><E><K><T><E><D><S><R><T><T><V><A><S><D><K><L><L><T><K><T><T><K><N><I><Q><E><T><I><S><A><N><E><L><T><Q><S><L><A><E><P><T><E><H><G><G><R><T><A><N><E><N><N><T><P><S><P><A><E><P><T><E><N><R><E><R><T><A><N><E><N><K><K><T><I><C><T><K><G><K><N><T><P><V><P><E><K><P><T><E><N><L><G><N><T><T><L><T><T><E><T><I><K><A><P><V><K><S><T><E><N><P><E><K><T><A><A><V><T><K><T><I><K><P><S><V><K><V><T><G><D><K><S><L><T><T><T><S><S><H><L><N><K><T><E><V><T><H><Q><V><P><T><G><S><F><T><L><I><T><S><R><T><K><L><S><S><I><T><S><E><A><T><G><N><E><S><H><P><Y><L><N><K><D><G><S><Q><K><G><I><H><A><G><Q><M><G><E><N><D><S><F><P><A><W><A><I><V><I><V><V><L><V><A><V><I><L><L><L><V><F><L><G><L><I><F><L><V><S><Y><M><M><R><T><R><R><T><L><T><Q><N><T><Q><Y><N><D><A><E><D><E><G><G><P><N><S><Y><P><V><Y><L><M><E><Q><Q><N><L><G><M><G><Q><I><P><S><P><R>
May modulate NF-kappaB signaling and play a role in cell growth.<BOP>
Q3MIW9
Q86Y28
BAGE4_HUMAN
Cancer/testis antigen 2.4
Homo
<M><A><A><G><A><V><F><L><A><L><S><A><Q><L><L><Q><A><R><L><M><K><E><E><S><P><V><V><S><W><W><L><E><P><E><D><G><T><A><L>
Unknown. Candidate gene encoding tumor antigens.<BOP>
Q86Y28
Q99856
ARI3A_HUMAN
E2F-binding protein 1
Homo
<M><K><L><Q><A><V><M><E><T><L><L><Q><R><Q><Q><R><A><R><Q><E><L><E><A><R><Q><Q><L><P><P><D><P><P><A><A><P><P><G><R><A><R><A><A><P><D><E><D><R><E><P><E><S><A><R><M><Q><R><A><Q><M><A><A><L><A><A><M><R><A><A><A><A><G><L><G><H><P><A><S><P><G><G><S><E><D><G><P><P><G><S><E><E><E><D><A><A><R><E><G><T><P><G><S><P><G><R><G><R><E><G><P><G><E><E><H><F><E><D><M><A><S><D><E><D><M><K><P><K><W><E><E><E><E><M><E><E><D><L><G><E><D><E><E><E><E><E><E><D><Y><E><D><E><E><E><E><E><D><E><E><G><L><G><P><P><G><P><A><S><L><G><T><T><A><L><F><P><R><K><A><Q><P><P><Q><A><F><R><G><D><G><V><P><R><V><L><G><G><Q><E><R><P><G><P><G><P><A><H><P><G><G><A><A><H><V><A><P><Q><L><Q><P><P><D><H><G><D><W><T><Y><E><E><Q><F><K><Q><L><Y><E><L><D><G><D><P><K><R><K><E><F><L><D><D><L><F><S><F><M><Q><K><R><G><T><P><V><N><R><I><P><I><M><A><K><Q><V><L><D><L><F><M><L><Y><V><L><V><T><E><K><G><G><L><V><E><V><I><N><K><K><L><W><R><E><I><T><K><G><L><N><L><P><T><S><I><T><S><A><A><F><T><L><R><T><Q><Y><M><K><Y><L><Y><P><Y><E><C><E><K><R><G><L><S><N><P><N><E><L><Q><A><A><I><D><S><N><R><R><E><G><R><R><Q><S><F><G><G><S><L><F><A><Y><S><P><G><G><A><H><G><M><L><S><S><P><K><L><P><V><S><S><L><G><L><A><A><S><T><N><G><S><S><I><T><P><A><P><K><I><K><K><E><E><D><S><A><I><P><I><T><V><P><G><R><L><P><V><S><L><A><G><H><P><V><V><A><A><Q><A><A><A><V><Q><A><A><A><A><Q><A><A><V><A><A><Q><A><A><A><L><E><Q><L><R><E><K><L><E><S><A><E><P><P><E><K><K><M><A><L><V><A><D><E><Q><Q><R><L><M><Q><R><A><L><Q><Q><N><F><L><A><M><A><A><Q><L><P><M><S><I><R><I><N><S><Q><A><S><E><S><R><Q><D><S><A><V><N><L><T><G><T><N><G><S><N><S><I><S><M><S><V><E><I><N><G><I><M><Y><T><G><V><L><F><A><Q><P><P><A><P><T><P><T><S><A><P><N><K><G><G><G><G><G><G><G><S><S><S><N><A><G><G><R><G><G><N><T><G><T><S><G><G><Q><A><G><P><A><G><L><S><T><P><S><T><S><T><S><N><N><S><L><P>
Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.<BOP>
Q99856
Q3LI70
KR196_HUMAN
Keratin-associated protein 19-6
Homo
<M><R><Y><Y><G><S><Y><Y><R><G><L><G><Y><G><C><G><G><F><G><G><L><G><Y><G><C><G><C><G><G><Y><R><Y><G><S><G><Y><G><G><Y><R><Y><G><C><C><R><P><S><C><R><E><G><Y><G><F><S><G><F><Y>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q3LI70
Q92915
FGF14_HUMAN
Fibroblast growth factor homologous factor 4
Homo
<M><A><A><A><I><A><S><G><L><I><R><Q><K><R><Q><A><R><E><Q><H><W><D><R><P><S><A><S><R><R><R><S><S><P><S><K><N><R><G><L><C><N><G><N><L><V><D><I><F><S><K><V><R><I><F><G><L><K><K><R><R><L><R><R><Q><D><P><Q><L><K><G><I><V><T><R><L><Y><C><R><Q><G><Y><Y><L><Q><M><H><P><D><G><A><L><D><G><T><K><D><D><S><T><N><S><T><L><F><N><L><I><P><V><G><L><R><V><V><A><I><Q><G><V><K><T><G><L><Y><I><A><M><N><G><E><G><Y><L><Y><P><S><E><L><F><T><P><E><C><K><F><K><E><S><V><F><E><N><Y><Y><V><I><Y><S><S><M><L><Y><R><Q><Q><E><S><G><R><A><W><F><L><G><L><N><K><E><G><Q><A><M><K><G><N><R><V><K><K><T><K><P><A><A><H><F><L><P><K><P><L><E><V><A><M><Y><R><E><P><S><L><H><D><V><G><E><T><V><P><K><P><G><V><T><P><S><K><S><T><S><A><S><A><I><M><N><G><G><K><P><V><N><K><S><K><T><T>
Probably involved in nervous system development and function.<BOP>
Q92915
P51677
CCR3_HUMAN
Eosinophil eotaxin receptor
Homo
<M><T><T><S><L><D><T><V><E><T><F><G><T><T><S><Y><Y><D><D><V><G><L><L><C><E><K><A><D><T><R><A><L><M><A><Q><F><V><P><P><L><Y><S><L><V><F><T><V><G><L><L><G><N><V><V><V><V><M><I><L><I><K><Y><R><R><L><R><I><M><T><N><I><Y><L><L><N><L><A><I><S><D><L><L><F><L><V><T><L><P><F><W><I><H><Y><V><R><G><H><N><W><V><F><G><H><G><M><C><K><L><L><S><G><F><Y><H><T><G><L><Y><S><E><I><F><F><I><I><L><L><T><I><D><R><Y><L><A><I><V><H><A><V><F><A><L><R><A><R><T><V><T><F><G><V><I><T><S><I><V><T><W><G><L><A><V><L><A><A><L><P><E><F><I><F><Y><E><T><E><E><L><F><E><E><T><L><C><S><A><L><Y><P><E><D><T><V><Y><S><W><R><H><F><H><T><L><R><M><T><I><F><C><L><V><L><P><L><L><V><M><A><I><C><Y><T><G><I><I><K><T><L><L><R><C><P><S><K><K><K><Y><K><A><I><R><L><I><F><V><I><M><A><V><F><F><I><F><W><T><P><Y><N><V><A><I><L><L><S><S><Y><Q><S><I><L><F><G><N><D><C><E><R><S><K><H><L><D><L><V><M><L><V><T><E><V><I><A><Y><S><H><C><C><M><N><P><V><I><Y><A><F><V><G><E><R><F><R><K><Y><L><R><H><F><F><H><R><H><L><L><M><H><L><G><R><Y><I><P><F><L><P><S><E><K><L><E><R><T><S><S><V><S><P><S><T><A><E><P><E><L><S><I><V><F>
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.<BOP>
P51677
O96000
NDUBA_HUMAN
NADH-ubiquinone oxidoreductase PDSW subunit
Homo
<M><P><D><S><W><D><K><D><V><Y><P><E><P><P><R><R><T><P><V><Q><P><N><P><I><V><Y><M><M><K><A><F><D><L><I><V><D><R><P><V><T><L><V><R><E><F><I><E><R><Q><H><A><K><N><R><Y><Y><Y><Y><H><R><Q><Y><R><R><V><P><D><I><T><E><C><K><E><E><D><I><M><C><M><Y><E><A><E><M><Q><W><K><R><D><Y><K><V><D><Q><E><I><I><N><I><M><Q><D><R><L><K><A><C><Q><Q><R><E><G><Q><N><Y><Q><Q><N><C><I><K><E><V><E><Q><F><T><Q><V><A><K><A><Y><Q><D><R><Y><Q><D><L><G><A><Y><S><S><A><R><K><C><L><A><K><Q><R><Q><R><M><L><Q><E><R><K><A><A><K><E><A><A><A><A><T><S>
Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.<BOP>
O96000
P54829
PTN5_HUMAN
Striatum-enriched protein-tyrosine phosphatase
Homo
<M><N><Y><E><G><A><R><S><E><R><E><N><H><A><A><D><D><S><E><G><G><A><L><D><M><C><C><S><E><R><L><P><G><L><P><Q><P><I><V><M><E><A><L><D><E><A><E><G><L><Q><D><S><Q><R><E><M><P><P><P><P><P><P><S><P><P><S><D><P><A><Q><K><P><P><P><R><G><A><G><S><H><S><L><T><V><R><S><S><L><C><L><F><A><A><S><Q><F><L><L><A><C><G><V><L><W><F><S><G><Y><G><H><I><W><S><Q><N><A><T><N><L><V><S><S><L><L><T><L><L><K><Q><L><E><P><T><A><W><L><D><S><G><T><W><G><V><P><S><L><L><L><V><F><L><S><V><G><L><V><L><V><T><T><L><V><W><H><L><L><R><T><P><P><E><P><P><T><P><L><P><P><E><D><R><R><Q><S><V><S><R><Q><P><S><F><T><Y><S><E><W><M><E><E><K><I><E><D><D><F><L><D><L><D><P><V><P><E><T><P><V><F><D><C><V><M><D><I><K><P><E><A><D><P><T><S><L><T><V><K><S><M><G><L><Q><E><R><R><G><S><N><V><S><L><T><L><D><M><C><T><P><G><C><N><E><E><G><F><G><Y><L><M><S><P><R><E><E><S><A><R><E><Y><L><L><S><A><S><R><V><L><Q><A><E><E><L><H><E><K><A><L><D><P><F><L><L><Q><A><E><F><F><E><I><P><M><N><F><V><D><P><K><E><Y><D><I><P><G><L><V><R><K><N><R><Y><K><T><I><L><P><N><P><H><S><R><V><C><L><T><S><P><D><P><D><D><P><L><S><S><Y><I><N><A><N><Y><I><R><G><Y><G><G><E><E><K><V><Y><I><A><T><Q><G><P><I><V><S><T><V><A><D><F><W><R><M><V><W><Q><E><H><T><P><I><I><V><M><I><T><N><I><E><E><M><N><E><K><C><T><E><Y><W><P><E><E><Q><V><A><Y><D><G><V><E><I><T><V><Q><K><V><I><H><T><E><D><Y><R><L><R><L><I><S><L><K><S><G><T><E><E><R><G><L><K><H><Y><W><F><T><S><W><P><D><Q><K><T><P><D><R><A><P><P><L><L><H><L><V><R><E><V><E><E><A><A><Q><Q><E><G><P><H><C><A><P><I><I><V><H><C><S><A><G><I><G><R><T><G><C><F><I><A><T><S><I><C><C><Q><Q><L><R><Q><E><G><V><V><D><I><L><K><T><T><C><Q><L><R><Q><D><R><G><G><M><I><Q><T><C><E><Q><Y><Q><F><V><H><H><V><M><S><L><Y><E><K><Q><L><S><H><Q><S><P><E>
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.<BOP>
P54829
Q13232
NDK3_HUMAN
nm23-H3
Homo
<M><I><C><L><V><L><T><I><F><A><N><L><F><P><A><A><C><T><G><A><H><E><R><T><F><L><A><V><K><P><D><G><V><Q><R><R><L><V><G><E><I><V><R><R><F><E><R><K><G><F><K><L><V><A><L><K><L><V><Q><A><S><E><E><L><L><R><E><H><Y><A><E><L><R><E><R><P><F><Y><G><R><L><V><K><Y><M><A><S><G><P><V><V><A><M><V><W><Q><G><L><D><V><V><R><T><S><R><A><L><I><G><A><T><N><P><A><D><A><P><P><G><T><I><R><G><D><F><C><I><E><V><G><K><N><L><I><H><G><S><D><S><V><E><S><A><R><R><E><I><A><L><W><F><R><A><D><E><L><L><C><W><E><D><S><A><G><H><W><L><Y><E>
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.<BOP>
Q13232
P41279
M3K8_HUMAN
Tumor progression locus 2
Homo
<M><E><Y><M><S><T><G><S><D><N><K><E><E><I><D><L><L><I><K><H><L><N><V><S><D><V><I><D><I><M><E><N><L><Y><A><S><E><E><P><A><V><Y><E><P><S><L><M><T><M><C><Q><D><S><N><Q><N><D><E><R><S><K><S><L><L><L><S><G><Q><E><V><P><W><L><S><S><V><R><Y><G><T><V><E><D><L><L><A><F><A><N><H><I><S><N><T><A><K><H><F><Y><G><Q><R><P><Q><E><S><G><I><L><L><N><M><V><I><T><P><Q><N><G><R><Y><Q><I><D><S><D><V><L><L><I><P><W><K><L><T><Y><R><N><I><G><S><D><F><I><P><R><G><A><F><G><K><V><Y><L><A><Q><D><I><K><T><K><K><R><M><A><C><K><L><I><P><V><D><Q><F><K><P><S><D><V><E><I><Q><A><C><F><R><H><E><N><I><A><E><L><Y><G><A><V><L><W><G><E><T><V><H><L><F><M><E><A><G><E><G><G><S><V><L><E><K><L><E><S><C><G><P><M><R><E><F><E><I><I><W><V><T><K><H><V><L><K><G><L><D><F><L><H><S><K><K><V><I><H><H><D><I><K><P><S><N><I><V><F><M><S><T><K><A><V><L><V><D><F><G><L><S><V><Q><M><T><E><D><V><Y><F><P><K><D><L><R><G><T><E><I><Y><M><S><P><E><V><I><L><C><R><G><H><S><T><K><A><D><I><Y><S><L><G><A><T><L><I><H><M><Q><T><G><T><P><P><W><V><K><R><Y><P><R><S><A><Y><P><S><Y><L><Y><I><I><H><K><Q><A><P><P><L><E><D><I><A><D><D><C><S><P><G><M><R><E><L><I><E><A><S><L><E><R><N><P><N><H><R><P><R><A><A><D><L><L><K><H><E><A><L><N><P><P><R><E><D><Q><P><R><C><Q><S><L><D><S><A><L><L><E><R><K><R><L><L><S><R><K><E><L><E><L><P><E><N><I><A><D><S><S><C><T><G><S><T><E><E><S><E><M><L><K><R><Q><R><S><L><Y><I><D><L><G><A><L><A><G><Y><F><N><L><V><R><G><P><P><T><L><E><Y><G>
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some
P41279
Q9BY41
HDAC8_HUMAN
Protein decrotonylase HDAC8
Homo
<M><E><E><P><E><E><P><A><D><S><G><Q><S><L><V><P><V><Y><I><Y><S><P><E><Y><V><S><M><C><D><S><L><A><K><I><P><K><R><A><S><M><V><H><S><L><I><E><A><Y><A><L><H><K><Q><M><R><I><V><K><P><K><V><A><S><M><E><E><M><A><T><F><H><T><D><A><Y><L><Q><H><L><Q><K><V><S><Q><E><G><D><D><D><H><P><D><S><I><E><Y><G><L><G><Y><D><C><P><A><T><E><G><I><F><D><Y><A><A><A><I><G><G><A><T><I><T><A><A><Q><C><L><I><D><G><M><C><K><V><A><I><N><W><S><G><G><W><H><H><A><K><K><D><E><A><S><G><F><C><Y><L><N><D><A><V><L><G><I><L><R><L><R><R><K><F><E><R><I><L><Y><V><D><L><D><L><H><H><G><D><G><V><E><D><A><F><S><F><T><S><K><V><M><T><V><S><L><H><K><F><S><P><G><F><F><P><G><T><G><D><V><S><D><V><G><L><G><K><G><R><Y><Y><S><V><N><V><P><I><Q><D><G><I><Q><D><E><K><Y><Y><Q><I><C><E><S><V><L><K><E><V><Y><Q><A><F><N><P><K><A><V><V><L><Q><L><G><A><D><T><I><A><G><D><P><M><C><S><F><N><M><T><P><V><G><I><G><K><C><L><K><Y><I><L><Q><W><Q><L><A><T><L><I><L><G><G><G><G><Y><N><L><A><N><T><A><R><C><W><T><Y><L><T><G><V><I><L><G><K><T><L><S><S><E><I><P><D><H><E><F><F><T><A><Y><G><P><D><Y><V><L><E><I><T><P><S><C><R><P><D><R><N><E><P><H><R><I><Q><Q><I><L><N><Y><I><K><G><N><L><K><H><V><V>
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events . Histone deacetylases act via the formation of large multiprotein complexes . Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin . May play a role in smooth muscle cell contractility . In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones .<BOP>
Q9BY41
Q9HD42
CHM1A_HUMAN
Vacuolar protein sorting-associated protein 46-1
Homo
<M><D><D><T><L><F><Q><L><K><F><T><A><K><Q><L><E><K><L><A><K><K><A><E><K><D><S><K><A><E><Q><A><K><V><K><K><A><L><L><Q><K><N><V><E><C><A><R><V><Y><A><E><N><A><I><R><K><K><N><E><G><V><N><W><L><R><M><A><S><R><V><D><A><V><A><S><K><V><Q><T><A><V><T><M><K><G><V><T><K><N><M><A><Q><V><T><K><A><L><D><K><A><L><S><T><M><D><L><Q><K><V><S><S><V><M><D><R><F><E><Q><Q><V><Q><N><L><D><V><H><T><S><V><M><E><D><S><M><S><S><A><T><T><L><T><T><P><Q><E><Q><V><D><S><L><I><M><Q><I><A><E><E><N><G><L><E><V><L><D><Q><L><S><Q><L><P><E><G><A><S><A><V><G><E><S><S><V><R><S><Q><E><D><Q><L><S><R><R><L><A><A><L><R><N>
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells
Q9HD42
Q9UGY1
NOL12_HUMAN
Nucleolar protein 12
Homo
<M><G><R><N><K><K><K><K><R><D><G><D><D><R><R><P><R><L><V><L><S><F><D><E><E><K><R><R><E><Y><L><T><G><F><H><K><R><K><V><E><R><K><K><A><A><I><E><E><I><K><Q><R><L><K><E><E><Q><R><K><L><R><E><E><R><H><Q><E><Y><L><K><M><L><A><E><R><E><E><A><L><E><E><A><D><E><L><D><R><L><V><T><A><K><T><E><S><V><Q><Y><D><H><P><N><H><T><V><T><V><T><T><I><S><D><L><D><L><S><G><A><R><L><L><G><L><T><P><P><E><G><G><A><G><D><R><S><E><E><E><A><S><S><T><E><K><P><T><K><A><L><P><R><K><S><R><D><P><L><L><S><Q><R><I><S><S><L><T><A><S><L><H><A><H><S><R><K><K><V><K><R><K><H><P><R><R><A><Q><D><S><K><K><P><P><R><A><P><R><T><S><K><A><Q><R><R><R><L><T><G><K><A><R><H><S><G><E>
May bind to 28S rRNA.<BOP>
Q9UGY1
Q9NZ43
USE1_HUMAN
p31
Homo
<M><A><A><S><R><L><E><L><N><L><V><R><L><L><S><R><C><E><A><M><A><A><E><K><R><D><P><D><E><W><R><L><E><K><Y><V><G><A><L><E><D><M><L><Q><A><L><K><V><H><A><S><K><P><A><S><E><V><I><N><E><Y><S><W><K><V><D><F><L><K><G><M><L><Q><A><E><K><L><T><S><S><S><E><K><A><L><A><N><Q><F><L><A><P><G><R><V><P><T><T><A><R><E><R><V><P><A><T><K><T><V><H><L><Q><S><R><A><R><Y><T><S><E><M><R><S><E><L><L><G><T><D><S><A><E><P><E><M><D><V><R><K><R><T><G><V><A><G><S><Q><P><V><S><E><K><Q><L><A><A><E><L><D><L><V><L><Q><R><H><Q><N><L><Q><E><K><L><A><E><E><M><L><G><L><A><R><S><L><K><T><N><T><L><A><A><Q><S><V><I><K><K><D><N><Q><T><L><S><H><S><L><K><M><A><D><Q><N><L><E><K><L><K><T><E><S><E><R><L><E><Q><H><T><Q><K><S><V><N><W><L><L><W><A><M><L><I><I><V><C><F><I><F><I><S><M><I><L><F><I><R><I><M><P><K><L><K>
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.<BOP>
Q9NZ43
Q6ZSJ9
SHSA6_HUMAN
Protein shisa-6
Homo
<M><A><L><R><R><L><L><L><L><L><L><L><S><L><E><S><L><D><L><L><P><S><V><H><G><A><R><G><R><A><A><N><R><T><L><S><A><G><G><A><A><V><G><G><R><R><A><G><G><A><L><A><R><G><G><R><E><L><N><G><T><A><R><A><P><G><I><P><E><A><G><S><R><R><G><Q><P><A><A><A><V><A><A><A><A><S><A><A><V><T><Y><E><T><C><W><G><Y><Y><D><V><S><G><Q><Y><D><K><E><F><E><C><N><N><S><E><S><G><Y><L><Y><C><C><G><T><C><Y><Y><R><F><C><C><K><K><R><H><E><K><L><D><Q><R><Q><C><T><N><Y><Q><S><P><V><W><V><Q><T><P><S><T><K><V><V><S><P><G><P><E><N><K><Y><D><P><E><K><D><K><T><N><F><T><V><Y><I><T><C><G><V><I><A><F><V><I><V><A><G><V><F><A><K><V><S><Y><D><K><A><H><R><P><P><R><E><M><N><I><H><R><A><L><A><D><I><L><R><Q><Q><G><P><I><P><I><A><H><C><E><R><E><T><I><S><A><I><D><T><S><P><K><E><N><T><P><V><R><S><S><S><K><N><H><Y><T><P><V><R><T><A><K><Q><T><P><E><K><P><R><M><N><N><I><L><T><S><A><T><E><P><Y><D><L><S><F><S><R><S><F><Q><N><L><A><H><L><P><P><S><Y><E><S><A><V><K><T><N><P><S><K><Y><S><S><L><K><R><L><T><D><K><E><A><D><E><Y><Y><M><R><R><R><H><L><P><D><L><A><A><R><G><T><L><P><L><N><V><I><Q><M><S><Q><Q><K><P><L><P><R><E><R><P><R><R><P><I><R><A><M><S><Q><D><R><V><L><S><P><D><R><G><L><P><D><E><F><S><M><P><Y><D><R><I><L><S><D><E><Q><L><L><S><T><E><R><L><H><S><Q><D><P><L><L><S><P><E><R><T><A><F><P><E><Q><S><L><S><R><A><I><S><H><T><D><V><F><V><S><T><P><V><L><D><R><Y><R><M><S><K><M><H><S><H><P><S><A><S><N><N><S><Y><A><T><L><G><Q><S><Q><T><A><A><K><R><H><A><F><A><S><R><R><H><N><T><V><E><Q><L><H><Y><I><P><G><H><H><T><C><Y><T><A><S><K><T><E><V><T><V>
Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway.<BOP>
Q6ZSJ9
Q8WXC3
PYDC1_HUMAN
cellular POP1
Homo
<M><G><T><K><R><E><A><I><L><K><V><L><E><N><L><T><P><E><E><L><K><K><F><K><M><K><L><G><T><V><P><L><R><E><G><F><E><R><I><P><R><G><A><L><G><Q><L><D><I><V><D><L><T><D><K><L><V><A><S><Y><Y><E><D><Y><A><A><E><L><V><V><A><V><L><R><D><M><R><M><L><E><E><A><A><R><L><Q><R><A><A>
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.<BOP>
Q8WXC3
Q9BY42
RTF2_HUMAN
Replication termination factor 2 domain-containing protein 1
Homo
<M><G><C><D><G><G><T><I><P><K><R><H><E><L><V><K><G><P><K><K><V><E><K><V><D><K><D><A><E><L><V><A><Q><W><N><Y><C><T><L><S><Q><E><I><L><R><R><P><I><V><A><C><E><L><G><R><L><Y><N><K><D><A><V><I><E><F><L><L><D><K><S><A><E><K><A><L><G><K><A><A><S><H><I><K><S><I><K><N><V><T><E><L><K><L><S><D><N><P><A><W><E><G><D><K><G><N><T><K><G><D><K><H><D><D><L><Q><R><A><R><F><I><C><P><V><V><G><L><E><M><N><G><R><H><R><F><C><F><L><R><C><C><G><C><V><F><S><E><R><A><L><K><E><I><K><A><E><V><C><H><T><C><G><A><A><F><Q><E><D><D><V><I><M><L><N><G><T><K><E><D><V><D><V><L><K><T><R><M><E><E><R><R><L><R><A><K><L><E><K><K><T><K><K><P><K><A><A><E><S><V><S><K><P><D><V><S><E><E><A><P><G><P><S><K><V><K><T><G><K><P><E><E><A><S><L><D><S><R><E><K><K><T><N><L><A><P><K><S><T><A><M><N><E><S><S><S><G><K><A><G><K><P><P><C><G><A><T><K><R><S><I><A><D><S><E><E><S><E><A><Y><K><S><L><F><T><T><H><S><S><A><K><R><S><K><E><E><S><A><H><W><V><T><H><T><S><Y><C><F>
Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA .<BOP>
Q9BY42
Q9UJN7
ZN391_HUMAN
Zinc finger protein 391
Homo
<M><E><S><L><R><G><N><T><A><Q><G><P><T><N><E><E><D><Y><K><N><E><G><Q><L><S><R><Q><T><K><C><P><A><Q><K><K><S><S><F><E><N><T><V><V><R><K><V><S><V><T><L><K><E><I><F><T><G><E><E><G><P><E><S><S><E><F><S><L><S><P><N><L><D><A><Q><Q><K><I><P><K><G><H><G><S><P><I><S><R><K><N><S><K><D><N><S><D><L><I><K><H><Q><R><L><F><S><Q><R><K><P><C><K><C><N><E><C><E><K><A><F><S><Y><Q><S><D><L><L><V><H><S><R><I><H><G><G><E><K><P><F><E><C><N><K><C><G><K><S><F><S><R><S><T><H><L><I><E><H><Q><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><R><S><T><H><L><S><L><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><S><R><S><T><N><L><S><Q><H><Q><R><T><H><T><Q><E><R><P><Y><K><C><N><E><C><G><K><A><F><G><D><R><S><T><I><I><Q><H><Q><R><I><H><T><G><E><N><P><Y><E><C><S><K><C><G><K><A><F><S><W><I><S><S><L><T><E><H><Q><R><T><H><T><G><E><N><P><Y><E><C><S><E><C><G><K><V><F><S><R><S><S><S><L><T><E><H><Q><R><I><H><S><G><E><K><P><H><E><C><R><V><C><G><K><G><F><S><R><S><S><S><L><I><I><H><Q><R><T><H><T><G><E><K><P><Y><K><C><N><D><C><G><K><A><F><C><Q><S><S><T><L><I><R><H><Q><H><L><H><T><K><E>
May be involved in transcriptional regulation.<BOP>
Q9UJN7