accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q6IF99
O10K2_HUMAN
Olfactory receptor OR1-4
Homo
<M><E><R><V><N><E><T><V><V><R><E><V><I><F><L><G><F><S><S><L><A><R><L><Q><Q><L><L><F><V><I><F><L><L><L><Y><L><F><T><L><G><T><N><A><I><I><I><S><T><I><V><L><D><R><A><L><H><I><P><M><Y><F><F><L><A><I><L><S><C><S><E><I><C><Y><T><F><I><I><V><P><K><M><L><V><D><L><L><S><Q><K><K><T><I><S><F><L><G><C><A><I><Q><M><F><S><F><L><F><L><G><C><S><H><S><F><L><L><A><V><M><G><Y><D><R><Y><I><A><I><C><N><P><L><R><Y><S><V><L><M><G><H><G><V><C><M><G><L><V><A><A><A><C><A><C><G><F><T><V><A><Q><I><I><T><S><L><V><F><H><L><P><F><Y><S><S><N><Q><L><H><H><F><F><C><D><I><A><P><V><L><K><L><A><S><H><H><N><H><F><S><Q><I><V><I><F><M><L><C><T><L><V><L><A><I><P><L><L><L><I><L><V><S><Y><V><H><I><L><S><A><I><L><Q><F><P><S><T><L><G><R><C><K><A><F><S><T><C><V><S><H><L><I><I><V><T><V><H><Y><G><C><A><S><F><I><Y><L><R><P><Q><S><N><Y><S><S><S><Q><D><A><L><I><S><V><S><Y><T><I><I><T><P><L><F><N><P><M><I><Y><S><L><R><N><K><E><F><K><S><A><L><C><K><I><V><R><R><T><I><S><L><L>
Odorant receptor.<BOP>
Q6IF99
Q96TC7
RMD3_HUMAN
TCPTP-interacting protein 51
Homo
<M><S><R><L><G><A><L><G><G><A><R><A><G><L><G><L><L><L><G><T><A><A><G><L><G><F><L><C><L><L><Y><S><Q><R><W><K><R><T><Q><R><H><G><R><S><Q><S><L><P><N><S><L><D><Y><T><Q><T><S><D><P><G><R><H><V><M><L><L><R><A><V><P><G><G><A><G><D><A><S><V><L><P><S><L><P><R><E><G><Q><E><K><V><L><D><R><L><D><F><V><L><T><S><L><V><A><L><R><R><E><V><E><E><L><R><S><S><L><R><G><L><A><G><E><I><V><G><E><V><R><C><H><M><E><E><N><Q><R><V><A><R><R><R><R><F><P><F><V><R><E><R><S><D><S><T><G><S><S><S><V><Y><F><T><A><S><S><G><A><T><F><T><D><A><E><S><E><G><G><Y><T><T><A><N><A><E><S><D><N><E><R><D><S><D><K><E><S><E><D><G><E><D><E><V><S><C><E><T><V><K><M><G><R><K><D><S><L><D><L><E><E><E><A><A><S><G><A><S><S><A><L><E><A><G><G><S><S><G><L><E><D><V><L><P><L><L><Q><Q><A><D><E><L><H><R><G><D><E><Q><G><K><R><E><G><F><Q><L><L><L><N><N><K><L><V><Y><G><S><R><Q><D><F><L><W><R><L><A><R><A><Y><S><D><M><C><E><L><T><E><E><V><S><E><K><K><S><Y><A><L><D><G><K><E><E><A><E><A><A><L><E><K><G><D><E><S><A><D><C><H><L><W><Y><A><V><L><C><G><Q><L><A><E><H><E><S><I><Q><R><R><I><Q><S><G><F><S><F><K><E><H><V><D><K><A><I><A><L><Q><P><E><N><P><M><A><H><F><L><L><G><R><W><C><Y><Q><V><S><H><L><S><W><L><E><K><K><T><A><T><A><L><L><E><S><P><L><S><A><T><V><E><D><A><L><Q><S><F><L><K><A><E><E><L><Q><P><G><F><S><K><A><G><R><V><Y><I><S><K><C><Y><R><E><L><G><K><N><S><E><A><R><W><W><M><K><L><A><L><E><L><P><D><V><T><K><E><D><L><A><I><Q><K><D><L><E><E><L><E><V><I><L><R><D>
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.<BOP>
Q96TC7
Q13595
TRA2A_HUMAN
Transformer-2 protein homolog A
Homo
<M><S><D><V><E><E><N><N><F><E><G><R><E><S><R><S><Q><S><K><S><P><T><G><T><P><A><R><V><K><S><E><S><R><S><G><S><R><S><P><S><R><V><S><K><H><S><E><S><H><S><R><S><R><S><K><S><R><S><R><S><R><R><H><S><H><R><R><Y><T><R><S><R><S><H><S><H><S><H><R><R><R><S><R><S><R><S><Y><T><P><E><Y><R><R><R><R><S><R><S><H><S><P><M><S><N><R><R><R><H><T><G><S><R><A><N><P><D><P><N><T><C><L><G><V><F><G><L><S><L><Y><T><T><E><R><D><L><R><E><V><F><S><R><Y><G><P><L><S><G><V><N><V><V><Y><D><Q><R><T><G><R><S><R><G><F><A><F><V><Y><F><E><R><I><D><D><S><K><E><A><M><E><R><A><N><G><M><E><L><D><G><R><R><I><R><V><D><Y><S><I><T><K><R><A><H><T><P><T><P><G><I><Y><M><G><R><P><T><H><S><G><G><G><G><G><G><G><G><G><G><G><G><G><G><G><G><R><R><R><D><S><Y><Y><D><R><G><Y><D><R><G><Y><D><R><Y><E><D><Y><D><Y><R><Y><R><R><R><S><P><S><P><Y><Y><S><R><Y><R><S><R><S><R><S><R><S><Y><S><P><R><R><Y>
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.<BOP>
Q13595
Q53H76
PLA1A_HUMAN
Phosphatidylserine-specific phospholipase A1
Homo
<M><P><P><G><P><W><E><S><C><F><W><V><G><G><L><I><L><W><L><S><V><G><S><S><G><D><A><P><P><T><P><Q><P><K><C><A><D><F><Q><S><A><N><L><F><E><G><T><D><L><K><V><Q><F><L><L><F><V><P><S><N><P><S><C><G><Q><L><V><E><G><S><S><D><L><Q><N><S><G><F><N><A><T><L><G><T><K><L><I><I><H><G><F><R><V><L><G><T><K><P><S><W><I><D><T><F><I><R><T><L><L><R><A><T><N><A><N><V><I><A><V><D><W><I><Y><G><S><T><G><V><Y><F><S><A><V><K><N><V><I><K><L><S><L><E><I><S><L><F><L><N><K><L><L><V><L><G><V><S><E><S><S><I><H><I><I><G><V><S><L><G><A><H><V><G><G><M><V><G><Q><L><F><G><G><Q><L><G><Q><I><T><G><L><D><P><A><G><P><E><Y><T><R><A><S><V><E><E><R><L><D><A><G><D><A><L><F><V><E><A><I><H><T><D><T><D><N><L><G><I><R><I><P><V><G><H><V><D><Y><F><V><N><G><G><Q><D><Q><P><G><C><P><T><F><F><Y><A><G><Y><S><Y><L><I><C><D><H><M><R><A><V><H><L><Y><I><S><A><L><E><N><S><C><P><L><M><A><F><P><C><A><S><Y><K><A><F><L><A><G><R><C><L><D><C><F><N><P><F><L><L><S><C><P><R><I><G><L><V><E><Q><G><G><V><K><I><E><P><L><P><K><E><V><K><V><Y><L><L><T><T><S><S><A><P><Y><C><M><H><H><S><L><V><E><F><H><L><K><E><L><R><N><K><D><T><N><I><E><V><T><F><L><S><S><N><I><T><S><S><S><K><I><T><I><P><K><Q><Q><R><Y><G><K><G><I><I><A><H><A><T><P><Q><C><Q><I><N><Q><V><K><F><K><F><Q><S><S><N><R><V><W><K><K><D><R><T><T><I><I><G><K><F><C><T><A><L><L><P><V><N><D><R><E><K><M><V><C><L><P><E><P><V><N><L><Q><A><S><V><T><V><S><C><D><L><K><I><A><C><V>
Hydrolyzes lyso-PS but not PS.<BOP>
Q53H76
P50616
TOB1_HUMAN
Transducer of erbB-2 1
Homo
<M><Q><L><E><I><Q><V><A><L><N><F><I><I><S><Y><L><Y><N><K><L><P><R><R><R><V><N><I><F><G><E><E><L><E><R><L><L><K><K><K><Y><E><G><H><W><Y><P><E><K><P><Y><K><G><S><G><F><R><C><I><H><I><G><E><K><V><D><P><V><I><E><Q><A><S><K><E><S><G><L><D><I><D><D><V><R><G><N><L><P><Q><D><L><S><V><W><I><D><P><F><E><V><S><Y><Q><I><G><E><K><G><P><V><K><V><L><Y><V><D><D><N><N><E><N><G><C><E><L><D><K><E><I><K><N><S><F><N><P><E><A><Q><V><F><M><P><I><S><D><P><A><S><S><V><S><S><S><P><S><P><P><F><G><H><S><A><A><V><S><P><T><F><M><P><R><S><T><Q><P><L><T><F><T><T><A><T><F><A><A><T><K><F><G><S><T><K><M><K><N><S><G><R><S><N><K><V><A><R><T><S><P><I><N><L><G><L><N><V><N><D><L><L><K><Q><K><A><I><S><S><S><M><H><S><L><Y><G><L><G><L><G><S><Q><Q><Q><P><Q><Q><Q><Q><Q><P><A><Q><P><P><P><P><P><P><P><P><Q><Q><Q><Q><Q><Q><K><T><S><A><L><S><P><N><A><K><E><F><I><F><P><N><M><Q><G><Q><G><S><S><T><N><G><M><F><P><G><D><S><P><L><N><L><S><P><L><Q><Y><S><N><A><F><D><V><F><A><A><Y><G><G><L><N><E><K><S><F><V><D><G><L><N><F><S><L><N><N><M><Q><Y><S><N><Q><Q><F><Q><P><V><M><A><N>
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex . Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay .<BOP>
P50616
Q9BZC1
CELF4_HUMAN
RNA-binding protein BRUNOL-4
Homo
<M><Y><I><K><M><A><T><L><A><N><G><Q><A><D><N><A><S><L><S><T><N><G><L><G><S><S><P><G><S><A><G><H><M><N><G><L><S><H><S><P><G><N><P><S><T><I><P><M><K><D><H><D><A><I><K><L><F><I><G><Q><I><P><R><N><L><D><E><K><D><L><K><P><L><F><E><E><F><G><K><I><Y><E><L><T><V><L><K><D><R><F><T><G><M><H><K><G><C><A><F><L><T><Y><C><E><R><E><S><A><L><K><A><Q><S><A><L><H><E><Q><K><T><L><P><G><M><N><R><P><I><Q><V><K><P><A><D><S><E><S><R><G><G><S><S><C><L><R><Q><P><P><S><Q><D><R><K><L><F><V><G><M><L><N><K><Q><Q><S><E><D><D><V><R><R><L><F><E><A><F><G><N><I><E><E><C><T><I><L><R><G><P><D><G><N><S><K><G><C><A><F><V><K><Y><S><S><H><A><E><A><Q><A><A><I><N><A><L><H><G><S><Q><T><M><P><G><A><S><S><S><L><V><V><K><F><A><D><T><D><K><E><R><T><M><R><R><M><Q><Q><M><A><G><Q><M><G><M><F><N><P><M><A><I><P><F><G><A><Y><G><A><Y><A><Q><A><L><M><Q><Q><Q><A><A><L><M><A><S><V><A><Q><G><G><Y><L><N><P><M><A><A><F><A><A><A><Q><M><Q><Q><M><A><A><L><N><M><N><G><L><A><A><A><P><M><T><P><T><S><G><G><S><T><P><P><G><I><T><A><P><A><V><P><S><I><P><S><P><I><G><V><N><G><F><T><G><L><P><P><Q><A><N><G><Q><P><A><A><E><A><V><F><A><N><G><I><H><P><Y><P><A><Q><S><P><T><A><A><D><P><L><Q><Q><A><Y><A><G><V><Q><Q><Y><A><G><P><A><A><Y><P><A><A><Y><G><Q><I><S><Q><A><F><P><Q><P><P><P><M><I><P><Q><Q><Q><R><E><G><P><E><G><C><N><L><F><I><Y><H><L><P><Q><E><F><G><D><A><E><L><M><Q><M><F><L><P><F><G><F><V><S><F><D><N><P><A><S><A><Q><T><A><I><Q><A><M><N><G><F><Q><I><G><M><K><R><L><K><V><Q><L><K><R><P><K><D><A><N><R><P><Y>
RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.<BOP>
Q9BZC1
P48230
T4S4_HUMAN
Intestine and liver tetraspan membrane protein
Homo
<M><C><T><G><G><C><A><R><C><L><G><G><T><L><I><P><L><A><F><F><G><F><L><A><N><I><L><L><F><F><P><G><G><K><V><I><D><D><N><D><H><L><S><Q><E><I><W><F><F><G><G><I><L><G><S><G><V><L><M><I><F><P><A><L><V><F><L><G><L><K><N><N><D><C><C><G><C><C><G><N><E><G><C><G><K><R><F><A><M><F><T><S><T><I><F><A><V><V><G><F><L><G><A><G><Y><S><F><I><I><S><A><I><S><I><N><K><G><P><K><C><L><M><A><N><S><T><W><G><Y><P><F><H><D><G><D><Y><L><N><D><E><A><L><W><N><K><C><R><E><P><L><N><V><V><P><W><N><L><T><L><F><S><I><L><L><V><V><G><G><I><Q><M><V><L><C><A><I><Q><V><V><N><G><L><L><G><T><L><C><G><D><C><Q><C><C><G><C><C><G><G><D><G><P><V>
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.<BOP>
P48230
P0C0E4
RB40L_HUMAN
Ras-like GTPase
Homo
<M><S><A><P><G><S><P><D><Q><A><Y><D><F><L><L><K><F><L><L><V><G><D><R><D><V><G><K><S><E><I><L><E><S><L><Q><D><G><T><A><E><S><P><Y><S><H><L><G><G><I><D><Y><K><T><T><T><I><L><L><D><G><Q><R><V><K><L><K><L><W><D><T><S><G><Q><G><R><F><C><T><I><F><R><S><Y><S><R><G><A><Q><G><V><I><L><V><Y><D><I><A><N><R><W><S><F><E><G><M><D><R><W><I><K><K><I><E><E><H><A><P><G><V><P><K><I><L><V><G><N><R><L><H><L><A><F><K><R><Q><V><P><R><E><Q><A><Q><A><Y><A><E><R><L><G><V><T><F><F><E><V><S><P><L><C><N><F><N><I><I><E><S><F><T><E><L><A><R><I><V><L><L><R><H><R><L><N><W><L><G><R><P><S><K><V><L><S><L><Q><D><L><C><C><R><T><I><V><S><C><T><P><V><H><L><V><D><K><L><P><L><P><I><A><L><R><S><H><L><K><S><F><S><M><A><K><G><L><N><A><R><M><M><R><G><L><S><Y><S><L><T><T><S><S><T><H><K><R><S><S><L><C><K><V><K><I><V><C><P><P><Q><S><P><P><K><N><C><T><R><N><S><C><K><I><S>
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<BOP>
P0C0E4
Q9HBM1
SPC25_HUMAN
Kinetochore protein Spc25
Homo
<M><V><E><D><E><L><A><L><F><D><K><S><I><N><E><F><W><N><K><F><K><S><T><D><T><S><C><Q><M><A><G><L><R><D><T><Y><K><D><S><I><K><A><F><A><E><K><L><S><V><K><L><K><E><E><E><R><M><V><E><M><F><L><E><Y><Q><N><Q><I><S><R><Q><N><K><L><I><Q><E><K><K><D><N><L><L><K><L><I><A><E><V><K><G><K><K><Q><E><L><E><V><L><T><A><N><I><Q><D><L><K><E><E><Y><S><R><K><K><E><T><I><S><T><A><N><K><A><N><A><E><R><L><K><R><L><Q><K><S><A><D><L><Y><K><D><R><L><G><L><E><I><R><K><I><Y><G><E><K><L><Q><F><I><F><T><N><I><D><P><K><N><P><E><S><P><F><M><F><S><L><H><L><N><E><A><R><D><Y><E><V><S><D><S><A><P><H><L><E><G><L><A><E><F><Q><E><N><V><R><K><T><N><N><F><S><A><F><L><A><N><V><R><K><A><F><T><A><T><V><Y><N>
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules .<BOP>
Q9HBM1
Q1W6H9
F110C_HUMAN
Protein FAM110C
Homo
<M><R><A><L><A><A><L><S><A><P><P><N><E><R><L><L><P><R><D><P><A><A><T><R><D><P><D><A><A><R><P><A><R><R><S><A><V><E><R><L><A><A><D><R><A><K><Y><V><R><G><R><P><G><T><G><R><G><V><A><S><E><G><S><G><P><G><A><I><K><C><P><G><N><D><P><G><P><P><A><R><A><P><A><P><V><A><R><R><A><I><A><R><K><P><L><R><P><D><S><L><I><I><Y><R><Q><K><C><E><F><V><R><G><S><G><A><D><G><P><R><A><S><L><V><K><K><L><F><Q><G><P><G><K><D><K><A><P><V><P><R><T><G><D><E><G><K><A><G><N><P><E><T><V><P><T><T><P><G><P><A><A><D><P><A><I><P><E><T><P><A><P><A><A><R><S><A><A><P><S><S><V><P><A><A><P><P><G><P><E><P><R><V><V><R><R><R><G><L><Q><R><S><Q><S><D><L><S><S><R><Y><S><A><A><L><A><E><S><D><T><F><F><Q><Y><C><G><L><D><P><E><V><V><E><A><L><G><R><E><N><F><T><A><G><S><D><C><V><T><L><K><V><R><S><V><S><V><A><T><S><G><S><G><F><S><R><H><S><G><G><D><D><E><G><L><Q><E><E><E><L><I><E><Q><V><P><S><T><T><S><V><I><E><R><N><A><R><I><I><K><W><L><Y><T><C><K><K><A><K><E><T><P><S><Q><E><Q><S><R><T><R><G><S><K><P><S><R>
May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.<BOP>
Q1W6H9
P60409
KR107_HUMAN
Keratin-associated protein 18.7
Homo
<M><A><A><S><T><M><S><V><C><S><S><D><L><S><Y><G><S><R><V><C><L><P><G><S><C><D><S><C><S><D><S><W><Q><V><D><D><C><P><E><S><C><C><E><P><P><C><C><A><P><A><P><C><L><S><L><V><C><T><P><V><S><Y><V><S><S><P><C><C><R><V><T><C><E><P><S><P><C><Q><S><G><C><T><S><S><C><T><P><S><C><C><Q><Q><S><S><C><Q><L><A><C><C><A><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><T><V><C><C><K><P><V><Y><C><V><P><V><C><S><G><D><S><S><C><C><Q><Q><S><S><C><Q><S><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><I><C><C><K><P><V><C><S><G><I><S><S><S><C><C><Q><Q><S><S><C><V><S><C><V><S><S><P><C><C><Q><A><V><C><E><P><S><P><C><Q><S><G><C><I><S><S><C><T><P><S><C><C><Q><Q><S><S><C><K><P><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><P><V><C><C><V><P><T><C><S><D><D><S><G><S><C><C><Q><P><A><C><C><T><S><S><Q><S><Q><Q><G><C><C><V><P><V><C><C><K><P><V><C><C><V><P><V><C><S><G><A><S><T><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><T><S><C><C><R><P><S><S><S><V><S><L><L><C><R><P><V><C><R><P><A><C><C><V><P><V><P><S><C><C><A><P><T><S><S><C><Q><A><S><C><C><R><P><A><S><C><V><S><L><L><C><R><P><A><C><S><R><P><A><C><C><G><P><T><S><T><Q><K><S><S><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
P60409
P63252
KCNJ2_HUMAN
Potassium channel, inwardly rectifying subfamily J member 2
Homo
<M><G><S><V><R><T><N><R><Y><S><I><V><S><S><E><E><D><G><M><K><L><A><T><M><A><V><A><N><G><F><G><N><G><K><S><K><V><H><T><R><Q><Q><C><R><S><R><F><V><K><K><D><G><H><C><N><V><Q><F><I><N><V><G><E><K><G><Q><R><Y><L><A><D><I><F><T><T><C><V><D><I><R><W><R><W><M><L><V><I><F><C><L><A><F><V><L><S><W><L><F><F><G><C><V><F><W><L><I><A><L><L><H><G><D><L><D><A><S><K><E><G><K><A><C><V><S><E><V><N><S><F><T><A><A><F><L><F><S><I><E><T><Q><T><T><I><G><Y><G><F><R><C><V><T><D><E><C><P><I><A><V><F><M><V><V><F><Q><S><I><V><G><C><I><I><D><A><F><I><I><G><A><V><M><A><K><M><A><K><P><K><K><R><N><E><T><L><V><F><S><H><N><A><V><I><A><M><R><D><G><K><L><C><L><M><W><R><V><G><N><L><R><K><S><H><L><V><E><A><H><V><R><A><Q><L><L><K><S><R><I><T><S><E><G><E><Y><I><P><L><D><Q><I><D><I><N><V><G><F><D><S><G><I><D><R><I><F><L><V><S><P><I><T><I><V><H><E><I><D><E><D><S><P><L><Y><D><L><S><K><Q><D><I><D><N><A><D><F><E><I><V><V><I><L><E><G><M><V><E><A><T><A><M><T><T><Q><C><R><S><S><Y><L><A><N><E><I><L><W><G><H><R><Y><E><P><V><L><F><E><E><K><H><Y><Y><K><V><D><Y><S><R><F><H><K><T><Y><E><V><P><N><T><P><L><C><S><A><R><D><L><A><E><K><K><Y><I><L><S><N><A><N><S><F><C><Y><E><N><E><V><A><L><T><S><K><E><E><D><D><S><E><N><G><V><P><E><S><T><S><T><D><T><P><P><D><I><D><L><H><N><Q><A><S><V><P><L><E><P><R><P><L><R><R><E><S><E><I>
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.<BOP>
P63252
P55010
IF5_HUMAN
Eukaryotic translation initiation factor 5
Homo
<M><S><V><N><V><N><R><S><V><S><D><Q><F><Y><R><Y><K><M><P><R><L><I><A><K><V><E><G><K><G><N><G><I><K><T><V><I><V><N><M><V><D><V><A><K><A><L><N><R><P><P><T><Y><P><T><K><Y><F><G><C><E><L><G><A><Q><T><Q><F><D><V><K><N><D><R><Y><I><V><N><G><S><H><E><A><N><K><L><Q><D><M><L><D><G><F><I><K><K><F><V><L><C><P><E><C><E><N><P><E><T><D><L><H><V><N><P><K><K><Q><T><I><G><N><S><C><K><A><C><G><Y><R><G><M><L><D><T><H><H><K><L><C><T><F><I><L><K><N><P><P><E><N><S><D><S><G><T><G><K><K><E><K><E><K><K><N><R><K><G><K><D><K><E><N><G><S><V><S><S><S><E><T><P><P><P><P><P><P><P><N><E><I><N><P><P><P><H><T><M><E><E><E><E><D><D><D><W><G><E><D><T><T><E><E><A><Q><R><R><R><M><D><E><I><S><D><H><A><K><V><L><T><L><S><D><D><L><E><R><T><I><E><E><R><V><N><I><L><F><D><F><V><K><K><K><K><E><E><G><V><I><D><S><S><D><K><E><I><V><A><E><A><E><R><L><D><V><K><A><M><G><P><L><V><L><T><E><V><L><F><N><E><K><I><R><E><Q><I><K><K><Y><R><R><H><F><L><R><F><C><H><N><N><K><K><A><Q><R><Y><L><L><H><G><L><E><C><V><V><A><M><H><Q><A><Q><L><I><S><K><I><P><H><I><L><K><E><M><Y><D><A><D><L><L><E><E><E><V><I><I><S><W><S><E><K><A><S><K><K><Y><V><S><K><E><L><A><K><E><I><R><V><K><A><E><P><F><I><K><W><L><K><E><A><E><E><E><S><S><G><G><E><E><E><D><E><D><E><N><I><E><V><V><Y><S><K><A><A><S><V><P><K><V><E><T><V><K><S><D><N><K><D><D><D><I><D><I><D><A><I>
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).<BOP>
P55010
P01601
KVD16_HUMAN
Ig kappa chain V-I region HK189
Homo
<M><D><M><R><V><L><A><Q><L><L><G><L><L><L><L><C><F><P><G><A><R><C><D><I><Q><M><T><Q><S><P><S><S><L><S><A><S><V><G><D><R><V><T><I><T><C><R><A><S><Q><G><I><S><S><W><L><A><W><Y><Q><Q><K><P><E><K><A><P><K><S><L><I><Y><A><A><S><S><L><Q><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><P><E><D><F><A><T><Y><Y><C><Q><Q><Y><N><S><Y><P>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P01601
Q13144
EI2BE_HUMAN
eIF-2B GDP-GTP exchange factor subunit epsilon
Homo
<M><A><A><P><V><V><A><P><P><G><V><V><V><S><R><A><N><K><R><S><G><A><G><P><G><G><S><G><G><G><G><A><R><G><A><E><E><E><P><P><P><P><L><Q><A><V><L><V><A><D><S><F><D><R><R><F><F><P><I><S><K><D><Q><P><R><V><L><L><P><L><A><N><V><A><L><I><D><Y><T><L><E><F><L><T><A><T><G><V><Q><E><T><F><V><F><C><C><W><K><A><A><Q><I><K><E><H><L><L><K><S><K><W><C><R><P><T><S><L><N><V><V><R><I><I><T><S><E><L><Y><R><S><L><G><D><V><L><R><D><V><D><A><K><A><L><V><R><S><D><F><L><L><V><Y><G><D><V><I><S><N><I><N><I><T><R><A><L><E><E><H><R><L><R><R><K><L><E><K><N><V><S><V><M><T><M><I><F><K><E><S><S><P><S><H><P><T><R><C><H><E><D><N><V><V><V><A><V><D><S><T><T><N><R><V><L><H><F><Q><K><T><Q><G><L><R><R><F><A><F><P><L><S><L><F><Q><G><S><S><D><G><V><E><V><R><Y><D><L><L><D><C><H><I><S><I><C><S><P><Q><V><A><Q><L><F><T><D><N><F><D><Y><Q><T><R><D><D><F><V><R><G><L><L><V><N><E><E><I><L><G><N><Q><I><H><M><H><V><T><A><K><E><Y><G><A><R><V><S><N><L><H><M><Y><S><A><V><C><A><D><V><I><R><R><W><V><Y><P><L><T><P><E><A><N><F><T><D><S><T><T><Q><S><C><T><H><S><R><H><N><I><Y><R><G><P><E><V><S><L><G><H><G><S><I><L><E><E><N><V><L><L><G><S><G><T><V><I><G><S><N><C><F><I><T><N><S><V><I><G><P><G><C><H><I><G><D><N><V><V><L><D><Q><T><Y><L><W><Q><G><V><R><V><A><A><G><A><Q><I><H><Q><S><L><L><C><D><N><A><E><V><K><E><R><V><T><L><K><P><R><S><V><L><T><S><Q><V><V><V><G><P><N><I><T><L><P><E><G><S><V><I><S><L><H><P><P><D><A><E><E><D><E><D><D><G><E><F><S><D><D><S><G><A><D><Q><E><K><D><K><V><K><M><K><G><Y><N><P><A><E><V><G><A><A><G><K><G><Y><L><W><K><A><A><G><M><N><M><E><E><E><E><E><L><Q><Q><N><L><W><G><L><K><I><N><M><E><E><E><S><E><S><E><S><E><Q><S><M><D><S><E><E><P><D><S><R><G><G><S><P><Q><M><D><D><I><K><V><F><Q><N><E><V><L><G><T><L><Q><R><G><K><E><E><N><I><S><C><D><N><L><V><L><E><I><N><S><L><K><Y><A><Y><N><I><S><L><K><E><V><M><Q><V><L><S><H><V><V><L><E><F><P><L><Q><Q><M><D><S><P><L><D><S><S><R><Y><C><A><L><L><L><P><L><L><K><A><W><S><P><V><F><R><N><Y><I><K><R><A><A><D><H><L><E><A><L><A><A><I><E><D><F><F><L><E><H><E><A><L><G><I><S><M><A><K><V><L><M><A><F><Y><Q><L><E><I><L><A><E><E><T><I><L><S><W><F><S><Q><R><D><T><T><D><K><G><Q><Q><L><R><K><N><Q><Q><L><Q><R><F><I><Q><W><L><K><E><A><E><E><E><S><S><E><D><D>
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.<BOP>
Q13144
Q8NHS9
SPT22_HUMAN
Testis development protein NYD-SP20
Homo
<M><K><R><S><L><N><E><N><S><A><R><S><T><A><G><C><L><P><V><P><L><F><N><Q><K><K><R><N><R><Q><P><L><T><S><N><P><L><K><D><D><S><G><I><S><T><P><S><D><N><Y><D><F><P><P><L><P><T><D><W><A><W><E><A><V><N><P><E><L><A><P><V><M><K><T><V><D><T><G><Q><I><P><H><S><V><S><R><P><L><R><S><Q><D><S><V><F><N><S><I><Q><S><N><T><G><R><S><Q><G><G><W><S><Y><R><D><G><N><K><N><T><S><L><K><T><W><N><K><N><D><F><K><P><Q><C><K><R><T><N><L><V><A><N><D><G><K><N><S><C><P><V><S><S><G><A><Q><Q><Q><K><Q><L><R><I><P><E><P><P><N><L><S><R><N><K><E><T><E><L><L><R><Q><T><H><S><S><K><I><S><G><C><T><M><R><G><L><D><K><N><S><A><L><Q><T><L><K><P><N><F><Q><Q><N><Q><Y><K><K><Q><M><L><D><D><I><P><E><D><N><T><L><K><E><T><S><L><Y><Q><L><Q><F><K><E><K><A><S><S><L><R><I><I><S><A><V><I><E><S><M><K><Y><W><R><E><H><A><Q><K><T><V><L><L><F><E><V><L><A><V><L><D><S><A><V><T><P><G><P><Y><Y><S><K><T><F><L><M><R><D><G><K><N><T><L><P><C><V><F><Y><E><I><D><R><E><L><P><R><L><I><R><G><R><V><H><R><C><V><G><N><Y><D><Q><K><K><N><I><F><Q><C><V><S><V><R><P><A><S><V><S><E><Q><K><T><F><Q><A><F><V><K><I><A><D><V><E><M><Q><Y><Y><I><N><V><M><N><E><T>
Meiosis-specific protein required for homologous recombination in meiosis I.<BOP>
Q8NHS9
A6NGC4
TLCD2_HUMAN
TLC domain-containing protein 2
Homo
<M><A><P><T><G><L><L><V><A><G><A><S><F><L><A><F><R><G><L><H><W><G><L><R><R><L><P><T><P><E><S><A><A><R><D><R><W><Q><W><W><N><L><C><V><S><L><A><H><S><L><L><S><G><T><G><A><L><L><G><L><S><L><Y><P><Q><M><A><A><D><P><I><H><G><H><P><R><W><A><L><V><L><V><A><V><S><V><G><Y><F><L><A><D><G><A><D><L><L><W><N><Q><T><L><G><K><T><W><D><L><L><C><H><H><L><V><V><V><S><C><L><S><T><A><V><L><S><G><H><Y><V><G><F><S><M><V><S><L><L><L><E><L><N><S><A><C><L><H><L><R><K><L><L><L><L><S><R><Q><A><P><S><L><A><F><S><V><T><S><W><A><S><L><A><T><L><A><L><F><R><L><V><P><L><G><W><M><S><L><W><L><F><R><Q><H><H><Q><V><P><L><A><L><V><T><L><G><G><I><G><L><V><T><V><G><I><M><S><I><I><L><G><I><R><I><L><V><N><D><V><L><Q><S><R><P><H><P><P><S><P><G><H><E><K><T><R><G><T><R><T><R><R><D><N><G><P><V><T><S><N><S><S><T><L><S><L><K><D>
Regulates the composition and fluidity of the plasma membrane . Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity . Does not appear to have any effect on LCPUFA synthesis .<BOP>
A6NGC4
Q9UHF1
EGFL7_HUMAN
Zneu1
Homo
<M><R><G><S><Q><E><V><L><L><M><W><L><L><V><L><A><V><G><G><T><E><H><A><Y><R><P><G><R><R><V><C><A><V><R><A><H><G><D><P><V><S><E><S><F><V><Q><R><V><Y><Q><P><F><L><T><T><C><D><G><H><R><A><C><S><T><Y><R><T><I><Y><R><T><A><Y><R><R><S><P><G><L><A><P><A><R><P><R><Y><A><C><C><P><G><W><K><R><T><S><G><L><P><G><A><C><G><A><A><I><C><Q><P><P><C><R><N><G><G><S><C><V><Q><P><G><R><C><R><C><P><A><G><W><R><G><D><T><C><Q><S><D><V><D><E><C><S><A><R><R><G><G><C><P><Q><R><C><V><N><T><A><G><S><Y><W><C><Q><C><W><E><G><H><S><L><S><A><D><G><T><L><C><V><P><K><G><G><P><P><R><V><A><P><N><P><T><G><V><D><S><A><M><K><E><E><V><Q><R><L><Q><S><R><V><D><L><L><E><E><K><L><Q><L><V><L><A><P><L><H><S><L><A><S><Q><A><L><E><H><G><L><P><D><P><G><S><L><L><V><H><S><F><Q><Q><L><G><R><I><D><S><L><S><E><Q><I><S><F><L><E><E><Q><L><G><S><C><S><C><K><K><D><S>
Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.<BOP>
Q9UHF1
A0PJZ3
GXLT2_HUMAN
Glycosyltransferase 8 domain-containing protein 4
Homo
<M><K><L><R><S><K><A><A><A><L><L><L><L><A><L><A><A><L><L><L><A><L><L><S><L><R><A><G><R><A><E><P><P><A><L><P><A><R><P><A><S><A><P><Q><R><H><P><A><P><V><P><A><R><W><P><G><P><G><A><L><P><G><A><S><P><G><V><R><R><R><R><P><P><R><P><R><P><R><A><G><R><R><G><A><A><R><L><E><K><L><A><R><R><P><G><E><P><R><S><F><Q><A><V><L><P><P><E><L><W><I><H><L><A><V><V><A><C><G><N><R><L><E><E><T><L><V><M><L><K><S><A><V><L><F><S><H><R><K><I><Q><F><H><I><F><T><E><D><S><L><K><P><E><F><D><K><Q><L><R><Q><W><P><D><S><Y><T><K><K><F><E><H><R><I><Y><P><I><T><F><S><V><G><N><P><Q><E><W><K><K><L><F><K><P><C><A><A><Q><R><L><F><L><P><V><I><L><K><D><V><D><S><L><L><Y><V><D><T><D><V><L><F><L><R><P><V><D><D><I><W><K><L><L><R><L><F><N><S><T><Q><L><A><A><M><A><P><E><H><E><I><P><K><I><G><W><Y><S><R><F><A><R><H><P><F><Y><G><S><A><G><V><N><S><G><V><M><L><M><N><L><T><R><I><R><S><T><Q><F><K><N><S><M><I><P><T><G><L><A><W><E><D><M><L><Y><P><L><Y><Q><K><Y><K><N><A><I><T><W><G><D><Q><D><L><L><N><I><I><F><Y><F><N><P><E><C><L><Y><V><F><P><C><Q><W><N><Y><R><P><D><H><C><M><Y><G><S><N><C><R><E><A><E><H><E><G><V><S><V><L><H><G><N><R><G><V><Y><H><D><D><K><Q><P><T><F><R><A><L><Y><E><A><I><R><D><F><P><F><Q><D><N><L><F><Q><S><M><Y><Y><P><L><Q><L><K><F><L><E><T><V><H><T><L><C><G><R><I><P><Q><V><F><L><K><Q><I><E><K><T><M><K><R><A><Y><E><K><H><V><I><I><H><V><G><P><N><Q><M><H>
Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.<BOP>
A0PJZ3
Q9BRT3
MIEN1_HUMAN
Protein C35
Homo
<M><S><G><E><P><G><Q><T><S><V><A><P><P><P><E><E><V><E><P><G><S><G><V><R><I><V><V><E><Y><C><E><P><C><G><F><E><A><T><Y><L><E><L><A><S><A><V><K><E><Q><Y><P><G><I><E><I><E><S><R><L><G><G><T><G><A><F><E><I><E><I><N><G><Q><L><V><F><S><K><L><E><N><G><G><F><P><Y><E><K><D><L><I><E><A><I><R><R><A><S><N><G><E><T><L><E><K><I><T><N><S><R><P><P><C><V><I><L>
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.<BOP>
Q9BRT3
Q96A56
T53I1_HUMAN
p53-dependent damage-inducible nuclear protein 1
Homo
<M><F><Q><R><L><N><K><M><F><V><G><E><V><S><S><S><S><N><Q><E><P><E><F><N><E><K><E><D><D><E><W><I><L><V><D><F><I><D><T><C><T><G><F><S><A><E><E><E><E><E><E><E><D><I><S><E><E><S><P><T><E><H><P><S><V><F><S><C><L><P><A><S><L><E><C><L><A><D><T><S><D><S><C><F><L><Q><F><E><S><C><P><M><E><E><S><W><F><I><T><P><P><P><C><F><T><A><G><G><L><T><T><I><K><V><E><T><S><P><M><E><N><L><L><I><E><H><P><S><M><S><V><Y><A><V><H><N><S><C><P><G><L><S><E><A><T><R><G><T><D><E><L><H><S><P><S><S><P><R><V><E><A><Q><N><E><M><G><Q><H><I><H><C><Y><V><A><A><L><A><A><H><T><T><F><L><E><Q><P><K><S><F><R><P><S><Q><W><I><K><E><H><S><E><R><Q><P><L><N><R><N><S><L><R><R><Q><N><L><T><R><D><C><H><P><R><Q><V><K><H><N><G><W><V><V><H><Q><P><C><P><R><Q><Y><N><Y>
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.<BOP>
Q96A56
Q14435
GALT3_HUMAN
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3
Homo
<M><A><H><L><K><R><L><V><K><L><H><I><K><R><H><Y><H><K><K><F><W><K><L><G><A><V><I><F><F><F><I><I><V><L><V><L><M><Q><R><E><V><S><V><Q><Y><S><K><E><E><S><R><M><E><R><N><M><K><N><K><N><K><M><L><D><L><M><L><E><A><V><N><N><I><K><D><A><M><P><K><M><Q><I><G><A><P><V><R><Q><N><I><D><A><G><E><R><P><C><L><Q><G><Y><Y><T><A><A><E><L><K><P><V><L><D><R><P><P><Q><D><S><N><A><P><G><A><S><G><K><A><F><K><T><T><N><L><S><V><E><E><Q><K><E><K><E><R><G><E><A><K><H><C><F><N><A><F><A><S><D><R><I><S><L><H><R><D><L><G><P><D><T><R><P><P><E><C><I><E><Q><K><F><K><R><C><P><P><L><P><T><T><S><V><I><I><V><F><H><N><E><A><W><S><T><L><L><R><T><V><H><S><V><L><Y><S><S><P><A><I><L><L><K><E><I><I><L><V><D><D><A><S><V><D><E><Y><L><H><D><K><L><D><E><Y><V><K><Q><F><S><I><V><K><I><V><R><Q><R><E><R><K><G><L><I><T><A><R><L><L><G><A><T><V><A><T><A><E><T><L><T><F><L><D><A><H><C><E><C><F><Y><G><W><L><E><P><L><L><A><R><I><A><E><N><Y><T><A><V><V><S><P><D><I><A><S><I><D><L><N><T><F><E><F><N><K><P><S><P><Y><G><S><N><H><N><R><G><N><F><D><W><S><L><S><F><G><W><E><S><L><P><D><H><E><K><Q><R><R><K><D><E><T><Y><P><I><K><T><P><T><F><A><G><G><L><F><S><I><S><K><E><Y><F><E><Y><I><G><S><Y><D><E><E><M><E><I><W><G><G><E><N><I><E><M><S><F><R><V><W><Q><C><G><G><Q><L><E><I><M><P><C><S><V><V><G><H><V><F><R><S><K><S><P><H><S><F><P><K><G><T><Q><V><I><A><R><N><Q><V><R><L><A><E><V><W><M><D><E><Y><K><E><I><F><Y><R><R><N><T><D><A><A><K><I><V><K><Q><K><A><F><G><D><L><S><K><R><F><E><I><K><H><R><L><Q><C><K><N><F><T><W><Y><L><N><N><I><Y><P><E><V><Y><V><P><D><L><N><P><V><I><S><G><Y><I><K><S><V><G><Q><P><L><C><L><D><V><G><E><N><N><Q><G><G><K><P><L><I><M><Y><T><C><H><G><L><G><G><N><Q><Y><F><E><Y><S><A><Q><H><E><I><R><H><N><I><Q><K><E><L><C><L><H><A><A><Q><G><L><V><Q><L><K><A><C><T><Y><K><G><H><K><T><V><V><T><G><E><Q><I><W><E><I><Q><K><D><Q><L><L><Y><N><P><F><L><K><M><C><L><S><A><N><G><E><H><P><S><L><V><S><C><N><P><S><D><P><L><Q><K><W><I><L><S><Q><N><D>
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis.<BOP>
Q14435
Q13148
TADBP_HUMAN
TAR DNA-binding protein 43
Homo
<M><S><E><Y><I><R><V><T><E><D><E><N><D><E><P><I><E><I><P><S><E><D><D><G><T><V><L><L><S><T><V><T><A><Q><F><P><G><A><C><G><L><R><Y><R><N><P><V><S><Q><C><M><R><G><V><R><L><V><E><G><I><L><H><A><P><D><A><G><W><G><N><L><V><Y><V><V><N><Y><P><K><D><N><K><R><K><M><D><E><T><D><A><S><S><A><V><K><V><K><R><A><V><Q><K><T><S><D><L><I><V><L><G><L><P><W><K><T><T><E><Q><D><L><K><E><Y><F><S><T><F><G><E><V><L><M><V><Q><V><K><K><D><L><K><T><G><H><S><K><G><F><G><F><V><R><F><T><E><Y><E><T><Q><V><K><V><M><S><Q><R><H><M><I><D><G><R><W><C><D><C><K><L><P><N><S><K><Q><S><Q><D><E><P><L><R><S><R><K><V><F><V><G><R><C><T><E><D><M><T><E><D><E><L><R><E><F><F><S><Q><Y><G><D><V><M><D><V><F><I><P><K><P><F><R><A><F><A><F><V><T><F><A><D><D><Q><I><A><Q><S><L><C><G><E><D><L><I><I><K><G><I><S><V><H><I><S><N><A><E><P><K><H><N><S><N><R><Q><L><E><R><S><G><R><F><G><G><N><P><G><G><F><G><N><Q><G><G><F><G><N><S><R><G><G><G><A><G><L><G><N><N><Q><G><S><N><M><G><G><G><M><N><F><G><A><F><S><I><N><P><A><M><M><A><A><A><Q><A><A><L><Q><S><S><W><G><M><M><G><M><L><A><S><Q><Q><N><Q><S><G><P><S><G><N><N><Q><N><Q><G><N><M><Q><R><E><P><N><Q><A><F><G><S><G><N><N><S><Y><S><G><S><N><S><G><A><A><I><G><W><G><S><A><S><N><A><G><S><G><S><G><F><N><G><G><F><G><S><S><M><D><S><K><S><S><G><W><G><M>
RNA-binding protein that is involved in various steps of RNA biogenesis and processing . Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs . In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases . Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts . Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening . In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival . Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins . Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner . Negatively regulates the expression of
Q13148
Q14050
CO9A3_HUMAN
Collagen alpha-3(IX) chain
Homo
<M><A><G><P><R><A><C><A><P><L><L><L><L><L><L><L><G><E><L><L><A><A><A><G><A><Q><R><V><G><L><P><G><P><P><G><P><P><G><P><P><G><K><P><G><Q><D><G><I><D><G><E><A><G><P><P><G><L><P><G><P><P><G><P><K><G><A><P><G><K><P><G><K><P><G><E><A><G><L><P><G><L><P><G><V><D><G><L><T><G><R><D><G><P><P><G><P><K><G><A><P><G><E><R><G><S><L><G><P><P><G><P><P><G><L><G><G><K><G><L><P><G><P><P><G><E><A><G><V><S><G><P><P><G><G><I><G><L><R><G><P><P><G><P><S><G><L><P><G><L><P><G><P><P><G><P><P><G><P><P><G><H><P><G><V><L><P><E><G><A><T><D><L><Q><C><P><S><I><C><P><P><G><P><P><G><P><P><G><M><P><G><F><K><G><P><T><G><Y><K><G><E><Q><G><E><V><G><K><D><G><E><K><G><D><P><G><P><P><G><P><A><G><L><P><G><S><V><G><L><Q><G><P><R><G><L><R><G><L><P><G><P><L><G><P><P><G><D><R><G><P><I><G><F><R><G><P><P><G><I><P><G><A><P><G><K><A><G><D><R><G><E><R><G><P><E><G><F><R><G><P><K><G><D><L><G><R><P><G><P><K><G><T><P><G><V><A><G><P><S><G><E><P><G><M><P><G><K><D><G><Q><N><G><V><P><G><L><D><G><Q><K><G><E><A><G><R><N><G><A><P><G><E><K><G><P><N><G><L><P><G><L><P><G><R><A><G><S><K><G><E><K><G><E><R><G><R><A><G><E><L><G><E><A><G><P><S><G><E><P><G><V><P><G><D><A><G><M><P><G><E><R><G><E><A><G><H><R><G><S><A><G><A><L><G><P><Q><G><P><P><G><A><P><G><V><R><G><F><Q><G><Q><K><G><S><M><G><D><P><G><L><P><G><P><Q><G><L><R><G><D><V><G><D><R><G><P><G><G><A><A><G><P><K><G><D><Q><G><I><A><G><S><D><G><L><P><G><D><K><G><E><L><G><P><S><G><L><V><G><P><K><G><E><S><G><S><R><G><E><L><G><P><K><G><T><Q><G><P><N><G><T><S><G><V><Q><G><V><P><G><P><P><G><P><L><G><L><Q><G><V><P><G><V><P><G><I><T><G><K><P><G><V><P><G><K><E><A><S><E><Q><R><I><R><E><L><C><G><G><M><I><S><E><Q><I><A><Q><L><A><A><H><L><R><K><P><L><A><P><G><S><I><G><R><P><G><P><A><G><P><P><G><P><P><G><P><P><G><S><I><G><H><P><G><A><R><G><P><P><G><Y><R><G><P><T><G><E><L><G><D><P><G><P><R><G><N><Q><G><D><R><G><D><K><G><A><A><G><A><G><L><D><G><P><E><G><D><Q><G><P><Q><G><P><Q><G><V><P><G><T><S><K><D><G><Q><D><G><A><P><G><E><P><G><P><P><G><D><P><G><L><P><G><A><I><G><A><Q><G><T><P><G><I><C><D><T><S><A><C><Q><G><A><V><L><G><G><V><G><E><K><S><G><S><R><S><S>
Structural component of hyaline cartilage and vitreous of the eye.<BOP>
Q14050
Q8NFH5
NUP35_HUMAN
Nucleoporin NUP53
Homo
<M><A><A><F><A><V><E><P><Q><G><P><A><L><G><S><E><P><M><M><L><G><S><P><T><S><P><K><P><G><V><N><A><Q><F><L><P><G><F><L><M><G><D><L><P><A><P><V><T><P><Q><P><R><S><I><S><G><P><S><V><G><V><M><E><M><R><S><P><L><L><A><G><G><S><P><P><Q><P><V><V><P><A><H><K><D><K><S><G><A><P><P><V><R><S><I><Y><D><D><I><S><S><P><G><L><G><S><T><P><L><T><S><R><R><Q><P><N><I><S><V><M><Q><S><P><L><V><G><V><T><S><T><P><G><T><G><Q><S><M><F><S><P><A><S><I><G><Q><P><R><K><T><T><L><S><P><A><Q><L><D><P><F><Y><T><Q><G><D><S><L><T><S><E><D><H><L><D><D><S><W><V><T><V><F><G><F><P><Q><A><S><A><S><Y><I><L><L><Q><F><A><Q><Y><G><N><I><L><K><H><V><M><S><N><T><G><N><W><M><H><I><R><Y><Q><S><K><L><Q><A><R><K><A><L><S><K><D><G><R><I><F><G><E><S><I><M><I><G><V><K><P><C><I><D><K><S><V><M><E><S><S><D><R><C><A><L><S><S><P><S><L><A><F><T><P><P><I><K><T><L><G><T><P><T><Q><P><G><S><T><P><R><I><S><T><M><R><P><L><A><T><A><Y><K><A><S><T><S><D><Y><Q><V><I><S><D><R><Q><T><P><K><K><D><E><S><L><V><S><K><A><M><E><Y><M><F><G><W>
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.<BOP>
Q8NFH5
Q7Z4H9
F220A_HUMAN
STAT3-interacting protein as a repressor
Homo
<M><R><D><R><R><G><P><L><G><T><C><L><A><Q><V><Q><Q><A><G><G><G><D><S><D><K><L><S><C><S><L><K><K><R><M><P><E><G><P><W><P><A><D><A><P><S><W><M><N><K><P><V><V><D><G><N><S><Q><S><E><A><L><S><L><E><M><R><K><D><P><S><G><A><G><L><W><L><H><S><G><G><P><V><L><P><Y><V><R><E><S><V><R><R><N><P><A><S><A><A><T><P><S><T><A><V><G><L><F><P><A><P><T><E><C><F><A><R><V><S><C><S><G><V><E><A><L><G><R><R><D><W><L><G><G><G><P><R><A><T><D><G><H><R><G><Q><C><P><K><G><E><P><R><V><S><R><L><P><R><H><Q><K><V><P><E><M><G><S><F><Q><D><D><P><P><S><A><F><P><K><G><L><G><S><E><L><E><P><A><C><L><H><S><I><L><S><A><T><L><H><V><Y><P><E><V><L><L><S><E><E><T><K><R><I><F><L><D><R><L><K><P><M><F><S><K><Q><T><I><E><F><K><K><M><L><K><S><T><S><D><G><L><Q><I><T><L><G><L><L><A><L><Q><P><F><E><L><A><N><T><L><C><H><S>
May negatively regulate STAT3.<BOP>
Q7Z4H9
P41440
S19A1_HUMAN
Solute carrier family 19 member 1
Homo
<M><V><P><S><S><P><A><V><E><K><Q><V><P><V><E><P><G><P><D><P><E><L><R><S><W><R><H><L><V><C><Y><L><C><F><Y><G><F><M><A><Q><I><R><P><G><E><S><F><I><T><P><Y><L><L><G><P><D><K><N><F><T><R><E><Q><V><T><N><E><I><T><P><V><L><S><Y><S><Y><L><A><V><L><V><P><V><F><L><L><T><D><Y><L><R><Y><T><P><V><L><L><L><Q><G><L><S><F><V><S><V><W><L><L><L><L><L><G><H><S><V><A><H><M><Q><L><M><E><L><F><Y><S><V><T><M><A><A><R><I><A><Y><S><S><Y><I><F><S><L><V><R><P><A><R><Y><Q><R><V><A><G><Y><S><R><A><A><V><L><L><G><V><F><T><S><S><V><L><G><Q><L><L><V><T><V><G><R><V><S><F><S><T><L><N><Y><I><S><L><A><F><L><T><F><S><V><V><L><A><L><F><L><K><R><P><K><R><S><L><F><F><N><R><D><D><R><G><R><C><E><T><S><A><S><E><L><E><R><M><N><P><G><P><G><G><K><L><G><H><A><L><R><V><A><C><G><D><S><V><L><A><R><M><L><R><E><L><G><D><S><L><R><R><P><Q><L><R><L><W><S><L><W><W><V><F><N><S><A><G><Y><Y><L><V><V><Y><Y><V><H><I><L><W><N><E><V><D><P><T><T><N><S><A><R><V><Y><N><G><A><A><D><A><A><S><T><L><L><G><A><I><T><S><F><A><A><G><F><V><K><I><R><W><A><R><W><S><K><L><L><I><A><G><V><T><A><T><Q><A><G><L><V><F><L><L><A><H><T><R><H><P><S><S><I><W><L><C><Y><A><A><F><V><L><F><R><G><S><Y><Q><F><L><V><P><I><A><T><F><Q><I><A><S><S><L><S><K><E><L><C><A><L><V><F><G><V><N><T><F><F><A><T><I><V><K><T><I><I><T><F><I><V><S><D><V><R><G><L><G><L><P><V><R><K><Q><F><Q><L><Y><S><V><Y><F><L><I><L><S><I><I><Y><F><L><G><A><M><L><D><G><L><R><H><C><Q><R><G><H><H><P><R><Q><P><P><A><Q><G><L><R><S><A><A><E><E><K><A><A><Q><A><L><S><V><Q><D><K><G><L><G><G><L><Q><P><A><Q><S><P><P><L><S><P><E><D><S><L><G><A><V><G><P><A><S><L><E><Q><R><Q><S><D><P><Y><L><A><Q><A><P><A><P><Q><A><A><E><F><L><S><P><V><T><T><P><S><P><C><T><L><C><S><A><Q><A><S><G><P><E><A><A><D><E><T><C><P><Q><L><A><V><H><P><P><G><V><S><K><L><G><L><Q><C><L><P><S><D><G><V><Q><N><V><N><Q>
Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions . Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates . Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate . Also able to mediate the import of antifolate drug methotrexate . Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses . 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity .<BOP>
P41440
O96011
PX11B_HUMAN
Protein PEX11 homolog beta
Homo
<M><D><A><W><V><R><F><S><A><Q><S><Q><A><R><E><R><L><C><R><A><A><Q><Y><A><C><S><L><L><G><H><A><L><Q><R><H><G><A><S><P><E><L><Q><K><Q><I><R><Q><L><E><S><H><L><S><L><G><R><K><L><L><R><L><G><N><S><A><D><A><L><E><S><A><K><R><A><V><H><L><S><D><V><V><L><R><F><C><I><T><V><S><H><L><N><R><A><L><Y><F><A><C><D><N><V><L><W><A><G><K><S><G><L><A><P><R><V><D><Q><E><K><W><A><Q><R><S><F><R><Y><Y><L><F><S><L><I><M><N><L><S><R><D><A><Y><E><I><R><L><L><M><E><Q><E><S><S><A><C><S><R><R><L><K><G><S><G><G><G><V><P><G><G><S><E><T><G><G><L><G><G><P><G><T><P><G><G><G><L><P><Q><L><A><L><K><L><R><L><Q><V><L><L><L><A><R><V><L><R><G><H><P><P><L><L><L><D><V><V><R><N><A><C><D><L><F><I><P><L><D><K><L><G><L><W><R><C><G><P><G><I><V><G><L><C><G><L><V><S><S><I><L><S><I><L><T><L><I><Y><P><W><L><R><L><K><P>
Involved in peroxisomal proliferation . May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane . Promotes membrane protrusion and elongation on the peroxisomal surface .<BOP>
O96011
P79483
DRB3_HUMAN
MHC class II antigen DRB3
Homo
<M><V><C><L><K><L><P><G><G><S><S><L><A><A><L><T><V><T><L><M><V><L><S><S><R><L><A><F><A><G><D><T><R><P><R><F><L><E><L><R><K><S><E><C><H><F><F><N><G><T><E><R><V><R><Y><L><D><R><Y><F><H><N><Q><E><E><F><L><R><F><D><S><D><V><G><E><Y><R><A><V><T><E><L><G><R><P><V><A><E><S><W><N><S><Q><K><D><L><L><E><Q><K><R><G><R><V><D><N><Y><C><R><H><N><Y><G><V><G><E><S><F><T><V><Q><R><R><V><H><P><Q><V><T><V><Y><P><A><K><T><Q><P><L><Q><H><H><N><L><L><V><C><S><V><S><G><F><Y><P><G><S><I><E><V><R><W><F><R><N><G><Q><E><E><K><A><G><V><V><S><T><G><L><I><Q><N><G><D><W><T><F><Q><T><L><V><M><L><E><T><V><P><R><S><G><E><V><Y><T><C><Q><V><E><H><P><S><V><T><S><A><L><T><V><E><W><R><A><R><S><E><S><A><Q><S><K><M><L><S><G><V><G><G><F><V><L><G><L><L><F><L><G><A><G><L><F><I><Y><F><R><N><Q><K><G><H><S><G><L><Q><P><T><G><F><L><S>
ALLELE DRB3*03:01: Presents a series of conserved peptides derived from the M. tuberculosis PPE family of proteins, in particular PPE29 and PPE33, known to be highly immunogenic . Presents immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a role in immune recognition and long-term protection . Displays immunodominant viral peptides from HCV non-structural protein NS2, as part of a broad range T-helper response to resolve infection .<BOP>
P79483
Q6IA17
SIGIR_HUMAN
Toll/interleukin-1 receptor 8
Homo
<M><P><G><V><C><D><R><A><P><D><F><L><S><P><S><E><D><Q><V><L><R><P><A><L><G><S><S><V><A><L><N><C><T><A><W><V><V><S><G><P><H><C><S><L><P><S><V><Q><W><L><K><D><G><L><P><L><G><I><G><G><H><Y><S><L><H><E><Y><S><W><V><K><A><N><L><S><E><V><L><V><S><S><V><L><G><V><N><V><T><S><T><E><V><Y><G><A><F><T><C><S><I><Q><N><I><S><F><S><S><F><T><L><Q><R><A><G><P><T><S><H><V><A><A><V><L><A><S><L><L><V><L><L><A><L><L><L><A><A><L><L><Y><V><K><C><R><L><N><V><L><L><W><Y><Q><D><A><Y><G><E><V><E><I><N><D><G><K><L><Y><D><A><Y><V><S><Y><S><D><C><P><E><D><R><K><F><V><N><F><I><L><K><P><Q><L><E><R><R><R><G><Y><K><L><F><L><D><D><R><D><L><L><P><R><A><E><P><S><A><D><L><L><V><N><L><S><R><C><R><R><L><I><V><V><L><S><D><A><F><L><S><R><A><W><C><S><H><S><F><R><E><G><L><C><R><L><L><E><L><T><R><R><P><I><F><I><T><F><E><G><Q><R><R><D><P><A><H><P><A><L><R><L><L><R><Q><H><R><H><L><V><T><L><L><L><W><R><P><G><S><V><T><P><S><S><D><F><W><K><E><V><Q><L><A><L><P><R><K><V><Q><Y><R><P><V><E><G><D><P><Q><T><Q><L><Q><D><D><K><D><P><M><L><I><L><R><G><R><V><P><E><G><R><A><L><D><S><E><V><D><P><D><P><E><G><D><L><G><V><R><G><P><V><F><G><E><P><S><A><P><P><H><T><S><G><V><S><L><G><E><S><R><S><S><E><V><D><V><S><D><L><G><S><R><N><Y><S><A><R><T><D><F><Y><C><L><V><S><K><D><D><M>
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.<BOP>
Q6IA17
Q8IVY1
CA210_HUMAN
Type III endosome membrane protein TEMP
Homo
<M><N><E><T><N><K><T><L><V><G><P><S><E><L><P><T><A><S><A><V><A><P><G><P><G><T><G><A><R><A><W><P><V><L><V><G><F><V><L><G><A><V><V><L><S><L><L><I><A><L><A><A><K><C><H><L><C><R><R><Y><H><A><S><Y><R><H><R><P><L><P><E><T><G><R><G><G><R><P><Q><V><A><E><D><E><D><D><D><G><F><I><E><D><N><Y><I><Q><P><G><T><G><E><L><G><T><E><G><S><R><D><H><F><S><L>
May be involved in membrane trafficking between endosomes and plasma membrane.<BOP>
Q8IVY1
Q9NZU1
FLRT1_HUMAN
Fibronectin-like domain-containing leucine-rich transmembrane protein 1
Homo
<M><D><L><R><D><W><L><F><L><C><Y><G><L><I><A><F><L><T><E><V><I><D><S><T><T><C><P><S><V><C><R><C><D><N><G><F><I><Y><C><N><D><R><G><L><T><S><I><P><A><D><I><P><D><D><A><T><T><L><Y><L><Q><N><N><Q><I><N><N><A><G><I><P><Q><D><L><K><T><K><V><N><V><Q><V><I><Y><L><Y><E><N><D><L><D><E><F><P><I><N><L><P><R><S><L><R><E><L><H><L><Q><D><N><N><V><R><T><I><A><R><D><S><L><A><R><I><P><L><L><E><K><L><H><L><D><D><N><S><V><S><T><V><S><I><E><E><D><A><F><A><D><S><K><Q><L><K><L><L><F><L><S><R><N><H><L><S><S><I><P><S><G><L><P><H><T><L><E><E><L><R><L><D><D><N><R><I><S><T><I><P><L><H><A><F><K><G><L><N><S><L><R><R><L><V><L><D><G><N><L><L><A><N><Q><R><I><A><D><D><T><F><S><R><L><Q><N><L><T><E><L><S><L><V><R><N><S><L><A><A><P><P><L><N><L><P><S><A><H><L><Q><K><L><Y><L><Q><D><N><A><I><S><H><I><P><Y><N><T><L><A><K><M><R><E><L><E><R><L><D><L><S><N><N><N><L><T><T><L><P><R><G><L><F><D><D><L><G><N><L><A><Q><L><L><L><R><N><N><P><W><F><C><G><C><N><L><M><W><L><R><D><W><V><K><A><R><A><A><V><V><N><V><R><G><L><M><C><Q><G><P><E><K><V><R><G><M><A><I><K><D><I><T><S><E><M><D><E><C><F><E><T><G><P><Q><G><G><V><A><N><A><A><A><K><T><T><A><S><N><H><A><S><A><T><T><P><Q><G><S><L><F><T><L><K><A><K><R><P><G><L><R><L><P><D><S><N><I><D><Y><P><M><A><T><G><D><G><A><K><T><L><A><I><H><V><K><A><L><T><A><D><S><I><R><I><T><W><K><A><T><L><P><A><S><S><F><R><L><S><W><L><R><L><G><H><S><P><A><V><G><S><I><T><E><T><L><V><Q><G><D><K><T><E><Y><L><L><T><A><L><E><P><K><S><T><Y><I><I><C><M><V><T><M><E><T><S><N><A><Y><V><A><D><E><T><P><V><C><A><K><A><E><T><A><D><S><Y><G><P><T><T><T><L><N><Q><E><Q><N><A><G><P><M><A><S><L><P><L><A><G><I><I><G><G><A><V><A><L><V><F><L><F><L><V><L><G><A><I><C><W><Y><V><H><Q><A><G><E><L><L><T><R><E><R><A><Y><N><R><G><S><R><K><K><D><D><Y><M><E><S><G><T><K><K><D><N><S><I><L><E><I><R><G><P><G><L><Q><M><L><P><I><N><P><Y><R><A><K><E><E><Y><V><V><H><T><I><F><P><S><N><G><S><S><L><C><K><A><T><H><T><I><G><Y><G><T><T><R><G><Y><R><D><G><G><I><P><D><I><D><Y><S><Y><T>
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.<BOP>
Q9NZU1
Q494V2
CP100_HUMAN
Coiled-coil domain-containing protein 37
Homo
<M><S><E><I><P><S><T><I><V><S><K><N><M><T><N><D><K><N><S><L><E><S><M><N><I><S><S><S><S><S><T><E><E><N><P><K><K><Q><A><R><K><N><E><E><H><G><P><D><P><S><A><N><P><F><H><L><S><G><D><V><D><F><F><L><L><R><D><Q><E><R><N><K><A><L><S><E><R><Q><Q><Q><K><T><M><R><V><H><Q><K><M><T><Y><S><S><K><V><S><A><K><H><T><S><L><R><R><Q><L><Q><L><E><D><K><Q><E><D><L><E><A><R><A><E><A><E><H><Q><R><A><F><R><D><Y><T><T><W><K><L><T><L><T><K><E><K><N><V><E><P><E><N><M><S><G><Y><I><K><Q><K><R><Q><M><F><L><L><Q><Y><A><L><D><V><K><R><R><E><I><Q><R><L><E><T><L><A><T><K><E><E><A><R><L><E><R><A><E><K><S><L><E><K><D><A><A><L><F><D><E><F><V><R><E><N><D><C><S><S><V><Q><A><M><R><A><A><E><K><E><T><K><A><K><I><E><K><I><L><E><I><R><D><L><T><T><Q><I><V><N><I><K><S><E><I><S><R><F><E><D><T><L><K><H><Y><K><V><Y><K><D><F><L><Y><K><L><S><P><K><E><W><L><E><E><Q><E><K><K><H><S><F><L><K><K><A><K><E><V><S><E><A><S><K><E><S><S><V><N><S><T><P><G><D><K><G><P><G><I><K><G><K><A><S><S><M><W><A><K><E><G><Q><G><T><K><K><P><W><R><F><L><Q><T><M><R><L><G><R><S><P><S><Y><L><S><S><P><Q><Q><G><S><Q><P><S><E><S><S><G><G><D><S><R><G><S><N><S><P><I><P><P><T><Q><E><D><T><D><S><D><G><E><E><P><Q><L><Y><F><T><E><P><Q><Q><L><L><D><V><F><R><E><L><E><E><Q><N><L><S><L><I><Q><N><S><Q><E><T><E><K><T><L><E><E><L><S><H><T><L><K><H><T><Q><I><R><M><D><R><E><V><N><Q><L><K><Q><W><V><T><T><M><M><M><S><I><T><K><E><E><D><T><A><A><E><L><E><L><K><A><R><V><F><H><F><G><E><Y><K><G><D><Q><Q><D><K><L><L><E><S><L><N><C><K><V><L><D><V><Y><R><H><C><T><G><T><Q><Q><E><A><N><L><G><T><V><Q><M><L><T><I><I><E><H><Q><L><D><E><L><L><E><N><L><E><H><V><P><Q><V><K><I><E><Q><A><E><R><A><K><E><K><E><R><R><I><R><L><R><E><E><K><L><Q><M><Q><K><I><L><Q><E><E><H><L><Q><R><A><R><A><R><A><Q><A><E><I><K><K><K><R><G><R><T><L><V><C><R><S><R><P><P><A><H><R><I><K><Q><Q><S><E><H><T><L><M><D><K><E><E><E><E><L><L><F><F><F><T>
May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.<BOP>
Q494V2
P00374
DYR_HUMAN
Dihydrofolate reductase
Homo
<M><V><G><S><L><N><C><I><V><A><V><S><Q><N><M><G><I><G><K><N><G><D><L><P><W><P><P><L><R><N><E><F><R><Y><F><Q><R><M><T><T><T><S><S><V><E><G><K><Q><N><L><V><I><M><G><K><K><T><W><F><S><I><P><E><K><N><R><P><L><K><G><R><I><N><L><V><L><S><R><E><L><K><E><P><P><Q><G><A><H><F><L><S><R><S><L><D><D><A><L><K><L><T><E><Q><P><E><L><A><N><K><V><D><M><V><W><I><V><G><G><S><S><V><Y><K><E><A><M><N><H><P><G><H><L><K><L><F><V><T><R><I><M><Q><D><F><E><S><D><T><F><F><P><E><I><D><L><E><K><Y><K><L><L><P><E><Y><P><G><V><L><S><D><V><Q><E><E><K><G><I><K><Y><K><F><E><V><Y><E><K><N><D>
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.<BOP>
P00374
Q9NY91
SC5A4_HUMAN
Solute carrier family 5 member 4
Homo
<M><A><S><T><V><S><P><S><T><I><A><E><T><P><E><P><P><P><L><S><D><H><I><R><N><A><A><D><I><S><V><I><V><I><Y><F><L><V><V><M><A><V><G><L><W><A><M><L><K><T><N><R><G><T><I><G><G><F><F><L><A><G><R><D><M><A><W><W><P><M><G><A><S><L><F><A><S><N><I><G><S><N><H><Y><V><G><L><A><G><T><G><A><A><S><G><V><A><T><V><T><F><E><W><T><S><S><V><M><L><L><I><L><G><W><I><F><V><P><I><Y><I><K><S><G><V><M><T><M><P><E><Y><L><K><K><R><F><G><G><E><R><L><Q><V><Y><L><S><I><L><S><L><F><I><C><V><V><L><L><I><S><A><D><I><F><A><G><A><I><F><I><K><L><A><L><G><L><D><L><Y><L><A><I><F><I><L><L><A><M><T><A><V><Y><T><T><T><G><G><L><A><S><V><I><Y><T><D><T><L><Q><T><I><I><M><L><I><G><S><F><I><L><M><G><F><A><F><N><E><V><G><G><Y><E><S><F><T><E><K><Y><V><N><A><T><P><S><V><V><E><G><D><N><L><T><I><S><A><S><C><Y><T><P><R><A><D><S><F><H><I><F><R><D><A><V><T><G><D><I><P><W><P><G><I><I><F><G><M><P><I><T><A><L><W><Y><W><C><T><N><Q><V><I><V><Q><R><C><L><C><G><K><D><M><S><H><V><K><A><A><C><I><M><C><A><Y><L><K><L><L><P><M><F><L><M><V><M><P><G><M><I><S><R><I><L><Y><T><D><M><V><A><C><V><V><P><S><E><C><V><K><H><C><G><V><D><V><G><C><T><N><Y><A><Y><P><T><M><V><L><E><L><M><P><Q><G><L><R><G><L><M><L><S><V><M><L><A><S><L><M><S><S><L><T><S><I><F><N><S><A><S><T><L><F><T><I><D><L><Y><T><K><M><R><K><Q><A><S><E><K><E><L><L><I><A><G><R><I><F><V><L><L><L><T><V><V><S><I><V><W><V><P><L><V><Q><V><S><Q><N><G><Q><L><I><H><Y><T><E><S><I><S><S><Y><L><G><P><P><I><A><A><V><F><V><L><A><I><F><C><K><R><V><N><E><Q><G><A><F><W><G><L><M><V><G><L><A><M><G><L><I><R><M><I><T><E><F><A><Y><G><T><G><S><C><L><A><P><S><N><C><P><K><I><I><C><G><V><H><Y><L><Y><F><S><I><V><L><F><F><G><S><M><L><V><T><L><G><I><S><L><L><T><K><P><I><P><D><V><H><L><Y><R><L><C><W><V><L><R><N><S><T><E><E><R><I><D><I><D><A><E><E><K><S><Q><E><E><T><D><D><G><V><E><E><D><Y><P><E><K><S><R><G><C><L><K><K><A><Y><D><L><F><C><G><L><Q><K><G><P><K><L><T><K><E><E><E><E><A><L><S><K><K><L><T><D><T><S><E><R><P><S><W><R><T><I><V><N><I><N><A><I><L><L><L><A><V><V><V><F><I><H><G><Y><Y><A>
Has electrogenic activity in response to glucose, and may function as a glucose sensor . Mediates influx of sodium ions into the cell but does not transport sugars . Also potently activated by imino sugars such as deoxynojirimycin (DNJ) .<BOP>
Q9NY91
Q9HB63
NET4_HUMAN
Hepar-derived netrin-like protein
Homo
<M><G><S><C><A><R><L><L><L><L><W><G><C><T><V><V><A><A><G><L><S><G><V><A><G><V><S><S><R><C><E><K><A><C><N><P><R><M><G><N><L><A><L><G><R><K><L><W><A><D><T><T><C><G><Q><N><A><T><E><L><Y><C><F><Y><S><E><N><T><D><L><T><C><R><Q><P><K><C><D><K><C><N><A><A><Y><P><H><L><A><H><L><P><S><A><M><A><D><S><S><F><R><F><P><R><T><W><W><Q><S><A><E><D><V><H><R><E><K><I><Q><L><D><L><E><A><E><F><Y><F><T><H><L><I><V><M><F><K><S><P><R><P><A><A><M><V><L><D><R><S><Q><D><F><G><K><T><W><K><P><Y><K><Y><F><A><T><N><C><S><A><T><F><G><L><E><D><D><V><V><K><K><G><A><I><C><T><S><K><Y><S><S><P><F><P><C><T><G><G><E><V><I><F><K><A><L><S><P><P><Y><D><T><E><N><P><Y><S><A><K><V><Q><E><Q><L><K><I><T><N><L><R><V><Q><L><L><K><R><Q><S><C><P><C><Q><R><N><D><L><N><E><E><P><Q><H><F><T><H><Y><A><I><Y><D><F><I><V><K><G><S><C><F><C><N><G><H><A><D><Q><C><I><P><V><H><G><F><R><P><V><K><A><P><G><T><F><H><M><V><H><G><K><C><M><C><K><H><N><T><A><G><S><H><C><Q><H><C><A><P><L><Y><N><D><R><P><W><E><A><A><D><G><K><T><G><A><P><N><E><C><R><T><C><K><C><N><G><H><A><D><T><C><H><F><D><V><N><V><W><E><A><S><G><N><R><S><G><G><V><C><D><D><C><Q><H><N><T><E><G><Q><Y><C><Q><R><C><K><P><G><F><Y><R><D><L><R><R><P><F><S><A><P><D><A><C><K><P><C><S><C><H><P><V><G><S><A><V><L><P><A><N><S><V><T><F><C><D><P><S><N><G><D><C><P><C><K><P><G><V><A><G><R><R><C><D><R><C><M><V><G><Y><W><G><F><G><D><Y><G><C><R><P><C><D><C><A><G><S><C><D><P><I><T><G><D><C><I><S><S><H><T><D><I><D><W><Y><H><E><V><P><D><F><R><P><V><H><N><K><S><E><P><A><W><E><W><E><D><A><Q><G><F><S><A><L><L><H><S><G><K><C><E><C><K><E><Q><T><L><G><N><A><K><A><F><C><G><M><K><Y><S><Y><V><L><K><I><K><I><L><S><A><H><D><K><G><T><H><V><E><V><N><V><K><I><K><K><V><L><K><S><T><K><L><K><I><F><R><G><K><R><T><L><Y><P><E><S><W><T><D><R><G><C><T><C><P><I><L><N><P><G><L><E><Y><L><V><A><G><H><E><D><I><R><T><G><K><L><I><V><N><M><K><S><F><V><Q><H><W><K><P><S><L><G><R><K><V><M><D><I><L><K><R><E><C><K>
May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.<BOP>
Q9HB63
P10599
THIO_HUMAN
Surface-associated sulphydryl protein
Homo
<M><V><K><Q><I><E><S><K><T><A><F><Q><E><A><L><D><A><A><G><D><K><L><V><V><V><D><F><S><A><T><W><C><G><P><C><K><M><I><K><P><F><F><H><S><L><S><E><K><Y><S><N><V><I><F><L><E><V><D><V><D><D><C><Q><D><V><A><S><E><C><E><V><K><C><M><P><T><F><Q><F><F><K><K><G><Q><K><V><G><E><F><S><G><A><N><K><E><K><L><E><A><T><I><N><E><L><V>
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<BOP>
P10599
Q6EMK4
VASN_HUMAN
Protein slit-like 2
Homo
<M><C><S><R><V><P><L><L><L><P><L><L><L><L><L><A><L><G><P><G><V><Q><G><C><P><S><G><C><Q><C><S><Q><P><Q><T><V><F><C><T><A><R><Q><G><T><T><V><P><R><D><V><P><P><D><T><V><G><L><Y><V><F><E><N><G><I><T><M><L><D><A><G><S><F><A><G><L><P><G><L><Q><L><L><D><L><S><Q><N><Q><I><A><S><L><P><S><G><V><F><Q><P><L><A><N><L><S><N><L><D><L><T><A><N><R><L><H><E><I><T><N><E><T><F><R><G><L><R><R><L><E><R><L><Y><L><G><K><N><R><I><R><H><I><Q><P><G><A><F><D><T><L><D><R><L><L><E><L><K><L><Q><D><N><E><L><R><A><L><P><P><L><R><L><P><R><L><L><L><L><D><L><S><H><N><S><L><L><A><L><E><P><G><I><L><D><T><A><N><V><E><A><L><R><L><A><G><L><G><L><Q><Q><L><D><E><G><L><F><S><R><L><R><N><L><H><D><L><D><V><S><D><N><Q><L><E><R><V><P><P><V><I><R><G><L><R><G><L><T><R><L><R><L><A><G><N><T><R><I><A><Q><L><R><P><E><D><L><A><G><L><A><A><L><Q><E><L><D><V><S><N><L><S><L><Q><A><L><P><G><D><L><S><G><L><F><P><R><L><R><L><L><A><A><A><R><N><P><F><N><C><V><C><P><L><S><W><F><G><P><W><V><R><E><S><H><V><T><L><A><S><P><E><E><T><R><C><H><F><P><P><K><N><A><G><R><L><L><L><E><L><D><Y><A><D><F><G><C><P><A><T><T><T><T><A><T><V><P><T><T><R><P><V><V><R><E><P><T><A><L><S><S><S><L><A><P><T><W><L><S><P><T><E><P><A><T><E><A><P><S><P><P><S><T><A><P><P><T><V><G><P><V><P><Q><P><Q><D><C><P><P><S><T><C><L><N><G><G><T><C><H><L><G><T><R><H><H><L><A><C><L><C><P><E><G><F><T><G><L><Y><C><E><S><Q><M><G><Q><G><T><R><P><S><P><T><P><V><T><P><R><P><P><R><S><L><T><L><G><I><E><P><V><S><P><T><S><L><R><V><G><L><Q><R><Y><L><Q><G><S><S><V><Q><L><R><S><L><R><L><T><Y><R><N><L><S><G><P><D><K><R><L><V><T><L><R><L><P><A><S><L><A><E><Y><T><V><T><Q><L><R><P><N><A><T><Y><S><V><C><V><M><P><L><G><P><G><R><V><P><E><G><E><E><A><C><G><E><A><H><T><P><P><A><V><H><S><N><H><A><P><V><T><Q><A><R><E><G><N><L><P><L><L><I><A><P><A><L><A><A><V><L><L><A><A><L><A><A><V><G><A><A><Y><C><V><R><R><G><R><A><M><A><A><A><A><Q><D><K><G><Q><V><G><P><G><A><G><P><L><E><L><E><G><V><K><V><P><L><E><P><G><P><K><A><T><E><G><G><G><E><A><L><P><S><G><S><E><C><E><V><P><L><M><G><F><P><G><P><G><L><Q><S><P><L><H><A><K><P><Y><I>
May act as an inhibitor of TGF-beta signaling.<BOP>
Q6EMK4
Q92966
SNPC3_HUMAN
snRNA-activating protein complex 50 kDa subunit
Homo
<M><A><E><G><S><R><G><G><P><T><C><S><G><V><G><G><R><Q><D><P><V><S><G><S><G><G><C><N><F><P><E><Y><E><L><P><E><L><N><T><R><A><F><H><V><G><A><F><G><E><L><W><R><G><R><L><R><G><A><G><D><L><S><L><R><E><P><P><A><S><A><L><P><G><S><Q><A><A><D><S><D><R><E><D><A><A><V><A><R><D><L><D><C><S><L><E><A><A><A><E><L><R><A><V><C><G><L><D><K><L><K><C><L><E><D><G><E><D><P><E><V><I><P><E><N><T><D><L><V><T><L><G><V><R><K><R><F><L><E><H><R><E><E><T><I><T><I><D><R><A><C><R><Q><E><T><F><V><Y><E><M><E><S><H><A><I><G><K><K><P><E><N><S><A><D><M><I><E><E><G><E><L><I><L><S><V><N><I><L><Y><P><V><I><F><H><K><H><K><E><H><K><P><Y><Q><T><M><L><V><L><G><S><Q><K><L><T><Q><L><R><D><S><I><R><C><V><S><D><L><Q><I><G><G><E><F><S><N><T><P><D><Q><A><P><E><H><I><S><K><D><L><Y><K><S><A><F><F><Y><F><E><G><T><F><Y><N><D><K><R><Y><P><E><C><R><D><L><S><R><T><I><I><E><W><S><E><S><H><D><R><G><Y><G><K><F><Q><T><A><R><M><E><D><F><T><F><N><D><L><C><I><K><L><G><F><P><Y><L><Y><C><H><Q><G><D><C><E><H><V><I><V><I><T><D><I><R><L><V><H><H><D><D><C><L><D><R><T><L><Y><P><L><L><I><K><K><H><W><L><W><T><R><K><C><F><V><C><K><M><Y><T><A><R><W><V><T><N><N><D><S><F><A><P><E><D><P><C><F><F><C><D><V><C><F><R><M><L><H><Y><D><S><E><G><N><K><L><G><E><F><L><A><Y><P><Y><V><D><P><G><T><F><N>
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.<BOP>
Q92966
P52740
ZN132_HUMAN
Zinc finger protein 132
Homo
<M><A><L><P><S><P><Q><V><L><M><G><L><P><A><L><L><M><G><P><A><Q><H><T><S><W><P><C><G><S><A><V><P><T><L><K><S><M><V><T><F><E><D><V><A><V><Y><F><S><Q><E><E><W><E><L><L><D><A><A><Q><R><H><L><Y><H><S><V><M><L><E><N><L><E><L><V><T><S><L><G><S><W><H><G><V><E><G><E><G><A><H><P><K><Q><N><V><S><V><E><V><L><Q><V><R><I><P><N><A><D><P><S><T><K><K><A><N><S><C><D><M><C><G><P><F><L><K><D><I><L><H><L><A><E><H><Q><G><T><Q><S><E><E><K><P><Y><T><C><G><A><C><G><R><D><F><W><L><N><A><N><L><H><Q><H><Q><K><E><H><S><G><G><K><P><F><R><W><Y><K><D><R><D><A><L><M><K><S><S><K><V><H><L><S><E><N><P><F><T><C><R><E><G><G><K><V><I><L><G><S><C><D><L><L><Q><L><Q><A><V><D><S><G><Q><K><P><Y><S><N><L><G><Q><L><P><E><V><C><T><T><Q><K><L><F><E><C><S><N><C><G><K><A><F><L><K><S><S><T><L><P><N><H><L><R><T><H><S><E><E><I><P><F><T><C><P><T><G><G><N><F><L><E><E><K><S><I><L><G><N><K><K><F><H><T><G><E><I><P><H><V><C><K><E><C><G><K><A><F><S><H><S><S><K><L><R><K><H><Q><K><F><H><T><E><V><K><Y><Y><E><C><I><A><C><G><K><T><F><N><H><K><L><T><F><V><H><H><Q><R><I><H><S><G><E><R><P><Y><E><C><D><E><C><G><K><A><F><S><N><R><S><H><L><I><R><H><E><K><V><H><T><G><E><R><P><F><E><C><L><K><C><G><R><A><F><S><Q><S><S><N><F><L><R><H><Q><K><V><H><T><Q><V><R><P><Y><E><C><S><Q><C><G><K><S><F><S><R><S><S><A><L><I><Q><H><W><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><R><A><F><N><N><N><S><N><L><A><Q><H><Q><K><V><H><T><G><E><R><P><F><E><C><S><E><C><G><R><D><F><S><Q><S><S><H><L><L><R><H><Q><K><V><H><T><G><E><R><P><F><E><C><C><D><C><G><K><A><F><S><N><S><S><T><L><I><Q><H><Q><K><V><H><T><G><Q><R><P><Y><E><C><S><E><C><R><K><S><F><S><R><S><S><S><L><I><Q><H><W><R><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><A><H><S><S><T><L><I><E><H><W><R><V><H><T><K><E><R><P><Y><E><C><N><E><C><G><K><F><F><S><Q><N><S><I><L><I><K><H><Q><K><V><H><T><G><E><K><P><Y><K><C><S><E><C><G><K><F><F><S><R><K><S><S><L><I><C><H><W><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><R><A><F><S><S><N><S><H><L><V><R><H><Q><R><V><H><T><Q><E><R><P><Y><E><C><I><Q><C><G><K><A><F><S><E><R><S><T><L><V><R><H><Q><K><V><H><T><R><E><R><T><Y><E><C><S><Q><C><G><K><L><F><S><H><L><C><N><L><A><Q><H><K><K><I><H><T>
May be involved in transcriptional regulation.<BOP>
P52740
Q9HC07
TM165_HUMAN
Transmembrane protein TPARL
Homo
<M><A><A><A><A><P><G><N><G><R><A><S><A><P><R><L><L><L><L><F><L><V><P><L><L><W><A><P><A><A><V><R><A><G><P><D><E><D><L><S><H><R><N><K><E><P><P><A><P><A><Q><Q><L><Q><P><Q><P><V><A><V><Q><G><P><E><P><A><R><V><E><K><I><F><T><P><A><A><P><V><H><T><N><K><E><D><P><A><T><Q><T><N><L><G><F><I><H><A><F><V><A><A><I><S><V><I><I><V><S><E><L><G><D><K><T><F><F><I><A><A><I><M><A><M><R><Y><N><R><L><T><V><L><A><G><A><M><L><A><L><G><L><M><T><C><L><S><V><L><F><G><Y><A><T><T><V><I><P><R><V><Y><T><Y><Y><V><S><T><V><L><F><A><I><F><G><I><R><M><L><R><E><G><L><K><M><S><P><D><E><G><Q><E><E><L><E><E><V><Q><A><E><L><K><K><K><D><E><E><F><Q><R><T><K><L><L><N><G><P><G><D><V><E><T><G><T><S><I><T><V><P><Q><K><K><W><L><H><F><I><S><P><I><F><V><Q><A><L><T><L><T><F><L><A><E><W><G><D><R><S><Q><L><T><T><I><V><L><A><A><R><E><D><P><Y><G><V><A><V><G><G><T><V><G><H><C><L><C><T><G><L><A><V><I><G><G><R><M><I><A><Q><K><I><S><V><R><T><V><T><I><I><G><G><I><V><F><L><A><F><A><F><S><A><L><F><I><S><P><D><S><G><F>
May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation.<BOP>
Q9HC07
Q5GAN4
RNS12_HUMAN
Probable inactive ribonuclease-like protein 12
Homo
<M><I><I><M><V><I><I><F><L><V><L><L><F><W><E><N><E><V><N><D><E><A><V><M><S><T><L><E><H><L><H><V><D><Y><P><Q><N><D><V><P><V><P><A><R><Y><C><N><H><M><I><I><Q><R><V><I><R><E><P><D><H><T><C><K><K><E><H><V><F><I><H><E><R><P><R><K><I><N><G><I><C><I><S><P><K><K><V><A><C><Q><N><L><S><A><I><F><C><F><Q><S><E><T><K><F><K><M><T><V><C><Q><L><I><E><G><T><R><Y><P><A><C><R><Y><H><Y><S><P><T><E><G><F><V><L><V><T><C><D><D><L><R><P><D><S><F><L><G><Y><V><K>
Does not exhibit any ribonuclease activity.<BOP>
Q5GAN4
Q8WV19
SFT2A_HUMAN
pRGR1
Homo
<M><E><K><L><R><R><V><L><S><G><Q><D><D><E><E><Q><G><L><T><A><Q><V><L><D><A><S><S><L><S><F><N><T><R><L><K><W><F><A><I><C><F><V><C><G><V><F><F><S><I><L><G><T><G><L><L><W><L><P><G><G><I><K><L><F><A><V><F><Y><T><L><G><N><L><A><A><L><A><S><T><C><F><L><M><G><P><V><K><Q><L><K><K><M><F><E><A><T><R><L><L><A><T><I><V><M><L><L><C><F><I><F><T><L><C><A><A><L><W><W><H><K><K><G><L><A><V><L><F><C><I><L><Q><F><L><S><M><T><W><Y><S><L><S><Y><I><P><Y><A><R><D><A><V><I><K><C><C><S><S><L><L><S>
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.<BOP>
Q8WV19
Q9P104
DOK5_HUMAN
Insulin receptor substrate 6
Homo
<M><A><S><N><F><N><D><I><V><K><Q><G><Y><V><R><I><R><S><R><R><L><G><I><Y><Q><R><C><W><L><V><F><K><K><A><S><S><K><G><P><K><R><L><E><K><F><S><D><E><R><A><A><Y><F><R><C><Y><H><K><V><T><E><L><N><N><V><K><N><V><A><R><L><P><K><S><T><K><K><H><A><I><G><I><Y><F><N><D><D><T><S><K><T><F><A><C><E><S><D><L><E><A><D><E><W><C><K><V><L><Q><M><E><C><V><G><T><R><I><N><D><I><S><L><G><E><P><D><L><L><A><T><G><V><E><R><E><Q><S><E><R><F><N><V><Y><L><M><P><S><P><N><L><D><V><H><G><E><C><A><L><Q><I><T><Y><E><Y><I><C><L><W><D><V><Q><N><P><R><V><K><L><I><S><W><P><L><S><A><L><R><R><Y><G><R><D><T><T><W><F><T><F><E><A><G><R><M><C><E><T><G><E><G><L><F><I><F><Q><T><R><D><G><E><A><I><Y><Q><K><V><H><S><A><A><L><A><I><A><E><Q><H><E><R><L><L><Q><S><V><K><N><S><M><L><Q><M><K><M><S><E><R><A><A><S><L><S><T><M><V><P><L><P><R><S><A><Y><W><Q><H><I><T><R><Q><H><S><T><G><Q><L><Y><R><L><Q><D><V><S><S><P><L><K><L><H><R><T><E><T><F><P><A><Y><R><S><E><H>
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.<BOP>
Q9P104
P17612
KAPCA_HUMAN
cAMP-dependent protein kinase catalytic subunit alpha
Homo
<M><G><N><A><A><A><A><K><K><G><S><E><Q><E><S><V><K><E><F><L><A><K><A><K><E><D><F><L><K><K><W><E><S><P><A><Q><N><T><A><H><L><D><Q><F><E><R><I><K><T><L><G><T><G><S><F><G><R><V><M><L><V><K><H><K><E><T><G><N><H><Y><A><M><K><I><L><D><K><Q><K><V><V><K><L><K><Q><I><E><H><T><L><N><E><K><R><I><L><Q><A><V><N><F><P><F><L><V><K><L><E><F><S><F><K><D><N><S><N><L><Y><M><V><M><E><Y><V><P><G><G><E><M><F><S><H><L><R><R><I><G><R><F><S><E><P><H><A><R><F><Y><A><A><Q><I><V><L><T><F><E><Y><L><H><S><L><D><L><I><Y><R><D><L><K><P><E><N><L><L><I><D><Q><Q><G><Y><I><Q><V><T><D><F><G><F><A><K><R><V><K><G><R><T><W><T><L><C><G><T><P><E><Y><L><A><P><E><I><I><L><S><K><G><Y><N><K><A><V><D><W><W><A><L><G><V><L><I><Y><E><M><A><A><G><Y><P><P><F><F><A><D><Q><P><I><Q><I><Y><E><K><I><V><S><G><K><V><R><F><P><S><H><F><S><S><D><L><K><D><L><L><R><N><L><L><Q><V><D><L><T><K><R><F><G><N><L><K><N><G><V><N><D><I><K><N><H><K><W><F><A><T><T><D><W><I><A><I><Y><Q><R><K><V><E><A><P><F><I><P><K><F><K><G><P><G><D><T><S><N><F><D><D><Y><E><E><E><E><I><R><V><S><I><N><E><K><C><G><K><E><F><S><E><F>
Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation.<BOP>
P17612
P50479
PDLI4_HUMAN
Reversion-induced LIM protein
Homo
<M><P><H><S><V><T><L><R><G><P><S><P><W><G><F><R><L><V><G><G><R><D><F><S><A><P><L><T><I><S><R><V><H><A><G><S><K><A><A><L><A><A><L><C><P><G><D><L><I><Q><A><I><N><G><E><S><T><E><L><M><T><H><L><E><A><Q><N><R><I><K><G><C><H><D><H><L><T><L><S><V><S><R><P><E><G><R><S><W><P><S><A><P><D><D><S><K><A><Q><A><H><R><I><H><I><D><P><E><I><Q><D><G><S><P><T><T><S><R><R><P><S><G><T><G><T><G><P><E><D><G><R><P><S><L><G><S><P><Y><G><Q><P><P><R><F><P><V><P><H><N><G><S><S><E><A><T><L><P><A><Q><M><S><T><L><H><V><S><P><P><P><S><A><D><P><A><R><G><L><P><R><S><R><D><C><R><V><D><L><G><S><E><V><Y><R><M><L><R><E><P><A><E><P><V><A><A><E><P><K><Q><S><G><S><F><R><Y><L><Q><G><M><L><E><A><G><E><G><G><D><W><P><G><P><G><G><P><R><N><L><K><P><T><A><S><K><L><G><A><P><L><S><G><L><Q><G><L><P><E><C><T><R><C><G><H><G><I><V><G><T><I><V><K><A><R><D><K><L><Y><H><P><E><C><F><M><C><S><D><C><G><L><N><L><K><Q><R><G><Y><F><F><L><D><E><R><L><Y><C><E><S><H><A><K><A><R><V><K><P><P><E><G><Y><D><V><V><A><V><Y><P><N><A><K><V><E><L><V>
Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration.<BOP>
P50479
Q6UXU4
GSG1L_HUMAN
Germ cell-specific gene 1-like protein
Homo
<M><K><T><S><R><R><G><R><A><L><L><A><V><A><L><N><L><L><A><L><L><F><A><T><T><A><F><L><T><T><H><W><C><Q><G><T><Q><R><V><P><K><P><G><C><G><Q><G><G><R><A><N><C><P><N><S><G><A><N><A><T><A><N><G><T><A><A><P><A><A><A><A><A><A><A><T><A><S><G><N><G><P><P><G><G><A><L><Y><S><W><E><T><G><D><D><R><F><L><F><R><N><F><H><T><G><I><W><Y><S><C><E><E><E><L><S><G><L><G><E><K><C><R><S><F><I><D><L><A><P><A><S><E><K><G><V><L><W><L><S><V><V><S><E><V><L><Y><I><L><L><L><V><V><G><F><S><L><M><C><L><E><L><F><H><S><S><N><V><I><D><G><L><K><L><N><A><F><A><A><V><F><T><V><L><S><G><L><L><G><M><V><A><H><M><M><Y><T><Q><V><F><Q><V><T><V><S><L><G><P><E><D><W><R><P><H><S><W><D><Y><G><W><S><F><C><L><A><W><G><S><F><T><C><C><M><A><A><S><V><T><T><L><N><S><Y><T><K><T><V><I><E><F><R><H><K><R><K><V><F><E><Q><G><Y><R><E><E><P><T><F><I><D><P><E><A><I><K><Y><F><R><E><R><M><E><K><R><D><G><S><E><E><D><F><H><L><D><C><R><H><E><R><Y><P><A><R><H><Q><P><H><M><A><D><S><W><P><R><S><S><A><Q><E><A><P><E><L><N><R><Q><C><W><V><L><G><H><W><V>
As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.<BOP>
Q6UXU4
Q5SXM1
ZN678_HUMAN
Zinc finger protein 678
Homo
<M><G><T><I><S><L><C><I><G><V><C><A><F><E><G><A><N><T><S><T><S><F><Y><K><L><V><Y><T><A><I><L><S><Y><S><I><Q><D><L><L><P><E><Q><D><M><K><D><L><C><Q><K><V><T><L><T><R><H><R><S><W><G><L><D><N><L><H><L><V><K><D><W><R><T><V><N><E><G><K><G><Q><K><E><Y><C><N><R><L><T><Q><C><S><S><T><K><S><K><I><F><Q><C><I><E><C><G><R><N><F><S><W><R><S><I><L><T><E><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><V><F><N><R><C><S><N><L><T><K><H><K><R><I><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><V><F><N><W><W><S><Q><L><T><N><H><K><K><I><H><T><G><E><K><P><Y><K><C><D><E><C><D><K><V><F><N><W><W><S><Q><L><T><S><H><K><K><I><H><S><G><E><K><P><Y><P><C><E><E><C><G><K><A><F><T><Q><F><S><N><L><T><Q><H><K><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><C><K><A><F><N><K><F><S><N><L><T><Q><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><N><V><F><N><E><C><S><H><L><T><R><H><R><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><T><Q><F><A><S><L><T><R><H><K><R><I><H><T><G><E><K><P><Y><Q><C><E><E><C><G><K><T><F><N><R><C><S><H><L><S><S><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><R><T><F><T><Q><F><S><N><L><T><Q><H><K><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><N><K><F><S><S><L><T><Q><H><R><R><I><H><T><G><V><K><P><Y><K><C><E><E><C><G><K><V><F><K><Q><C><S><H><L><T><S><H><K><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><Y><Q><S><S><I><L><S><K><H><K><R><I><H><T><E><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><F><S><S><L><T><R><H><K><R><I><H><T><G><E><K><R><Y><K><C><K><E><C><G><K><G><F><Y><Q><S><S><I><H><S><K><Y><K><R><I><Y><T><G><E><E><P><D><K><C><K><K><C><G><S><L>
May be involved in transcriptional regulation.<BOP>
Q5SXM1
Q86U28
ISCA2_HUMAN
HESB-like domain-containing protein 1
Homo
<M><A><A><A><W><G><S><S><L><T><A><A><T><Q><R><A><V><T><P><W><P><R><G><R><L><L><T><A><S><L><G><P><Q><A><R><R><E><A><S><S><S><S><P><E><A><G><E><G><Q><I><R><L><T><D><S><C><V><Q><R><L><L><E><I><T><E><G><S><E><F><L><R><L><Q><V><E><G><G><G><C><S><G><F><Q><Y><K><F><S><L><D><T><V><I><N><P><D><D><R><V><F><E><Q><G><G><A><R><V><V><V><D><S><D><S><L><A><F><V><K><G><A><Q><V><D><F><S><Q><E><L><I><R><S><S><F><Q><V><L><N><N><P><Q><A><Q><Q><G><C><S><C><G><S><S><F><S><I><K><L>
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.<BOP>
Q86U28
P16435
NCPR_HUMAN
NADPH--cytochrome P450 reductase
Homo
<M><G><D><S><H><V><D><T><S><S><T><V><S><E><A><V><A><E><E><V><S><L><F><S><M><T><D><M><I><L><F><S><L><I><V><G><L><L><T><Y><W><F><L><F><R><K><K><K><E><E><V><P><E><F><T><K><I><Q><T><L><T><S><S><V><R><E><S><S><F><V><E><K><M><K><K><T><G><R><N><I><I><V><F><Y><G><S><Q><T><G><T><A><E><E><F><A><N><R><L><S><K><D><A><H><R><Y><G><M><R><G><M><S><A><D><P><E><E><Y><D><L><A><D><L><S><S><L><P><E><I><D><N><A><L><V><V><F><C><M><A><T><Y><G><E><G><D><P><T><D><N><A><Q><D><F><Y><D><W><L><Q><E><T><D><V><D><L><S><G><V><K><F><A><V><F><G><L><G><N><K><T><Y><E><H><F><N><A><M><G><K><Y><V><D><K><R><L><E><Q><L><G><A><Q><R><I><F><E><L><G><L><G><D><D><D><G><N><L><E><E><D><F><I><T><W><R><E><Q><F><W><P><A><V><C><E><H><F><G><V><E><A><T><G><E><E><S><S><I><R><Q><Y><E><L><V><V><H><T><D><I><D><A><A><K><V><Y><M><G><E><M><G><R><L><K><S><Y><E><N><Q><K><P><P><F><D><A><K><N><P><F><L><A><A><V><T><T><N><R><K><L><N><Q><G><T><E><R><H><L><M><H><L><E><L><D><I><S><D><S><K><I><R><Y><E><S><G><D><H><V><A><V><Y><P><A><N><D><S><A><L><V><N><Q><L><G><K><I><L><G><A><D><L><D><V><V><M><S><L><N><N><L><D><E><E><S><N><K><K><H><P><F><P><C><P><T><S><Y><R><T><A><L><T><Y><Y><L><D><I><T><N><P><P><R><T><N><V><L><Y><E><L><A><Q><Y><A><S><E><P><S><E><Q><E><L><L><R><K><M><A><S><S><S><G><E><G><K><E><L><Y><L><S><W><V><V><E><A><R><R><H><I><L><A><I><L><Q><D><C><P><S><L><R><P><P><I><D><H><L><C><E><L><L><P><R><L><Q><A><R><Y><Y><S><I><A><S><S><S><K><V><H><P><N><S><V><H><I><C><A><V><V><V><E><Y><E><T><K><A><G><R><I><N><K><G><V><A><T><N><W><L><R><A><K><E><P><A><G><E><N><G><G><R><A><L><V><P><M><F><V><R><K><S><Q><F><R><L><P><F><K><A><T><T><P><V><I><M><V><G><P><G><T><G><V><A><P><F><I><G><F><I><Q><E><R><A><W><L><R><Q><Q><G><K><E><V><G><E><T><L><L><Y><Y><G><C><R><R><S><D><E><D><Y><L><Y><R><E><E><L><A><Q><F><H><R><D><G><A><L><T><Q><L><N><V><A><F><S><R><E><Q><S><H><K><V><Y><V><Q><H><L><L><K><Q><D><R><E><H><L><W><K><L><I><E><G><G><A><H><I><Y><V><C><G><D><A><R><N><M><A><R><D><V><Q><N><T><F><Y><D><I><V><A><E><L><G><A><M><E><H><A><Q><A><V><D><Y><I><K><K><L><M><T><K><G><R><Y><S><L><D><V><W><S>
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.<BOP>
P16435
P35711
SOX5_HUMAN
Transcription factor SOX-5
Homo
<M><L><T><D><P><D><L><P><Q><E><F><E><R><M><S><S><K><R><P><A><S><P><Y><G><E><A><D><G><E><V><A><M><V><T><S><R><Q><K><V><E><E><E><E><S><D><G><L><P><A><F><H><L><P><L><H><V><S><F><P><N><K><P><H><S><E><E><F><Q><P><V><S><L><L><T><Q><E><T><C><G><H><R><T><P><T><S><Q><H><N><T><M><E><V><D><G><N><K><V><M><S><S><F><A><P><H><N><S><S><T><S><P><Q><K><A><E><E><G><G><R><Q><S><G><E><S><L><S><S><T><A><L><G><T><P><E><R><R><K><G><S><L><A><D><V><V><D><T><L><K><Q><R><K><M><E><E><L><I><K><N><E><P><E><E><T><P><S><I><E><K><L><L><S><K><D><W><K><D><K><L><L><A><M><G><S><G><N><F><G><E><I><K><G><T><P><E><S><L><A><E><K><E><R><Q><L><M><G><M><I><N><Q><L><T><S><L><R><E><Q><L><L><A><A><H><D><E><Q><K><K><L><A><A><S><Q><I><E><K><Q><R><Q><Q><M><E><L><A><K><Q><Q><Q><E><Q><I><A><R><Q><Q><Q><Q><L><L><Q><Q><Q><H><K><I><N><L><L><Q><Q><Q><I><Q><V><Q><G><Q><L><P><P><L><M><I><P><V><F><P><P><D><Q><R><T><L><A><A><A><A><Q><Q><G><F><L><L><P><P><G><F><S><Y><K><A><G><C><S><D><P><Y><P><V><Q><L><I><P><T><T><M><A><A><A><A><A><A><T><P><G><L><G><P><L><Q><L><Q><Q><L><Y><A><A><Q><L><A><A><M><Q><V><S><P><G><G><K><L><P><G><I><P><Q><G><N><L><G><A><A><V><S><P><T><S><I><H><T><D><K><S><T><N><S><P><P><P><K><S><K><D><E><V><A><Q><P><L><N><L><S><A><K><P><K><T><S><D><G><K><S><P><T><S><P><T><S><P><H><M><P><A><L><R><I><N><S><G><A><G><P><L><K><A><S><V><P><A><A><L><A><S><P><S><A><R><V><S><T><I><G><Y><L><N><D><H><D><A><V><T><K><A><I><Q><E><A><R><Q><M><K><E><Q><L><R><R><E><Q><Q><V><L><D><G><K><V><A><V><V><N><S><L><G><L><N><N><C><R><T><E><K><E><K><T><T><L><E><S><L><T><Q><Q><L><A><V><K><Q><N><E><E><G><K><F><S><H><A><M><M><D><F><N><L><S><G><D><S><D><G><S><A><G><V><S><E><S><R><I><Y><R><E><S><R><G><R><G><S><N><E><P><H><I><K><R><P><M><N><A><F><M><V><W><A><K><D><E><R><R><K><I><L><Q><A><F><P><D><M><H><N><S><N><I><S><K><I><L><G><S><R><W><K><A><M><T><N><L><E><K><Q><P><Y><Y><E><E><Q><A><R><L><S><K><Q><H><L><E><K><Y><P><D><Y><K><Y><K><P><R><P><K><R><T><C><L><V><D><G><K><K><L><R><I><G><E><Y><K><A><I><M><R><N><R><R><Q><E><M><R><Q><Y><F><N><V><G><Q><Q><A><Q><I><P><I><A><T><A><G><V><V><Y><P><G><A><I><A><M><A><G><M><P><S><P><H><L><P><S><E><H><S><S><V><S><S><S><P><E><P><G><M><P><V><I><Q><S><T><Y><G><V><K><G><E><E><P><H><I><K><E><E><I><Q><A><E><D><I><N><G><E><I><Y><D><E><Y><D><E><E><E><D><D><P><D><V><D><Y><G><S><D><S><E><N><H><I><A><G><Q><A><N>
Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin
P35711
Q07869
PPARA_HUMAN
Nuclear receptor subfamily 1 group C member 1
Homo
<M><V><D><T><E><S><P><L><C><P><L><S><P><L><E><A><G><D><L><E><S><P><L><S><E><E><F><L><Q><E><M><G><N><I><Q><E><I><S><Q><S><I><G><E><D><S><S><G><S><F><G><F><T><E><Y><Q><Y><L><G><S><C><P><G><S><D><G><S><V><I><T><D><T><L><S><P><A><S><S><P><S><S><V><T><Y><P><V><V><P><G><S><V><D><E><S><P><S><G><A><L><N><I><E><C><R><I><C><G><D><K><A><S><G><Y><H><Y><G><V><H><A><C><E><G><C><K><G><F><F><R><R><T><I><R><L><K><L><V><Y><D><K><C><D><R><S><C><K><I><Q><K><K><N><R><N><K><C><Q><Y><C><R><F><H><K><C><L><S><V><G><M><S><H><N><A><I><R><F><G><R><M><P><R><S><E><K><A><K><L><K><A><E><I><L><T><C><E><H><D><I><E><D><S><E><T><A><D><L><K><S><L><A><K><R><I><Y><E><A><Y><L><K><N><F><N><M><N><K><V><K><A><R><V><I><L><S><G><K><A><S><N><N><P><P><F><V><I><H><D><M><E><T><L><C><M><A><E><K><T><L><V><A><K><L><V><A><N><G><I><Q><N><K><E><A><E><V><R><I><F><H><C><C><Q><C><T><S><V><E><T><V><T><E><L><T><E><F><A><K><A><I><P><G><F><A><N><L><D><L><N><D><Q><V><T><L><L><K><Y><G><V><Y><E><A><I><F><A><M><L><S><S><V><M><N><K><D><G><M><L><V><A><Y><G><N><G><F><I><T><R><E><F><L><K><S><L><R><K><P><F><C><D><I><M><E><P><K><F><D><F><A><M><K><F><N><A><L><E><L><D><D><S><D><I><S><L><F><V><A><A><I><I><C><C><G><D><R><P><G><L><L><N><V><G><H><I><E><K><M><Q><E><G><I><V><H><V><L><R><L><H><L><Q><S><N><H><P><D><D><I><F><L><F><P><K><L><L><Q><K><M><A><D><L><R><Q><L><V><T><E><H><A><Q><L><V><Q><I><I><K><K><T><E><S><D><A><A><L><H><P><L><L><Q><E><I><Y><R><D><M><Y>
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.<BOP>
Q07869
Q5DT21
ISK9_HUMAN
Lymphoepithelial Kazal-type-related inhibitor 2
Homo
<M><R><A><T><A><I><V><L><L><L><A><L><T><L><A><T><M><F><S><I><E><C><A><K><Q><T><K><Q><M><V><D><C><S><H><Y><K><K><L><P><P><G><Q><Q><R><F><C><H><H><M><Y><D><P><I><C><G><S><D><G><K><T><Y><K><N><D><C><F><F><C><S><K><V><K><K><T><D><G><T><L><K><F><V><H><F><G><K><C>
Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.<BOP>
Q5DT21
Q7Z6M4
MTEF4_HUMAN
mTERF domain-containing protein 2 processed
Homo
<M><A><A><F><G><R><Q><V><L><D><W><H><R><L><I><P><L><T><W><A><C><M><A><R><Q><T><P><H><L><G><E><Q><R><R><T><T><A><S><L><L><R><K><L><T><T><A><S><N><G><G><V><I><E><E><L><S><C><V><R><S><N><N><Y><V><Q><E><P><E><C><R><R><N><L><V><Q><C><L><L><E><K><Q><G><T><P><V><V><Q><G><S><L><E><L><E><R><V><M><S><S><L><L><D><M><G><F><S><N><A><H><I><N><E><L><L><S><V><R><R><G><A><S><L><Q><Q><L><L><D><I><I><S><E><F><I><L><L><G><L><N><P><E><P><V><C><V><V><L><K><K><S><P><Q><L><L><K><L><P><I><M><Q><M><R><K><R><S><S><Y><L><Q><K><L><G><L><G><E><G><K><L><K><R><V><L><Y><C><C><P><E><I><F><T><M><R><Q><Q><D><I><N><D><T><V><R><L><L><K><E><K><C><L><F><T><V><Q><Q><V><T><K><I><L><H><S><C><P><S><V><L><R><E><D><L><G><Q><L><E><Y><K><F><Q><Y><A><Y><F><R><M><G><I><K><H><P><D><I><V><K><S><E><Y><L><Q><Y><S><L><T><K><I><K><Q><R><H><I><Y><L><E><R><L><G><R><Y><Q><T><P><D><K><K><G><Q><T><Q><I><P><N><P><L><L><K><D><I><L><R><V><S><E><A><E><F><L><A><R><T><A><C><T><S><V><E><E><F><Q><V><F><K><K><L><L><A><R><E><E><E><E><S><E><S><S><T><S><D><D><K><R><A><S><L><D><E><D><E><D><D><D><D><E><E><D><N><D><E><D><D><N><D><E><D><D><D><D><E><D><D><D><E><A><E><D><N><D><E><D><E><D><D><D><E><E><E>
Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).<BOP>
Q7Z6M4
O43715
TRIA1_HUMAN
p53-inducible cell-survival factor
Homo
<M><N><S><V><G><E><A><C><T><D><M><K><R><E><Y><D><Q><C><F><N><R><W><F><A><E><K><F><L><K><G><D><S><S><G><D><P><C><T><D><L><F><K><R><Y><Q><Q><C><V><Q><K><A><I><K><E><K><E><I><P><I><E><G><L><E><F><M><G><H><G><K><E><K><P><E><N><S><S>
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane . Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) . Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis .<BOP>
O43715
O43155
FLRT2_HUMAN
Fibronectin-like domain-containing leucine-rich transmembrane protein 2
Homo
<M><G><L><Q><T><T><K><W><P><S><H><G><A><F><F><L><K><S><W><L><I><I><S><L><G><L><Y><S><Q><V><S><K><L><L><A><C><P><S><V><C><R><C><D><R><N><F><V><Y><C><N><E><R><S><L><T><S><V><P><L><G><I><P><E><G><V><T><V><L><Y><L><H><N><N><Q><I><N><N><A><G><F><P><A><E><L><H><N><V><Q><S><V><H><T><V><Y><L><Y><G><N><Q><L><D><E><F><P><M><N><L><P><K><N><V><R><V><L><H><L><Q><E><N><N><I><Q><T><I><S><R><A><A><L><A><Q><L><L><K><L><E><E><L><H><L><D><D><N><S><I><S><T><V><G><V><E><D><G><A><F><R><E><A><I><S><L><K><L><L><F><L><S><K><N><H><L><S><S><V><P><V><G><L><P><V><D><L><Q><E><L><R><V><D><E><N><R><I><A><V><I><S><D><M><A><F><Q><N><L><T><S><L><E><R><L><I><V><D><G><N><L><L><T><N><K><G><I><A><E><G><T><F><S><H><L><T><K><L><K><E><F><S><I><V><R><N><S><L><S><H><P><P><P><D><L><P><G><T><H><L><I><R><L><Y><L><Q><D><N><Q><I><N><H><I><P><L><T><A><F><S><N><L><R><K><L><E><R><L><D><I><S><N><N><Q><L><R><M><L><T><Q><G><V><F><D><N><L><S><N><L><K><Q><L><T><A><R><N><N><P><W><F><C><D><C><S><I><K><W><V><T><E><W><L><K><Y><I><P><S><S><L><N><V><R><G><F><M><C><Q><G><P><E><Q><V><R><G><M><A><V><R><E><L><N><M><N><L><L><S><C><P><T><T><T><P><G><L><P><L><F><T><P><A><P><S><T><A><S><P><T><T><Q><P><P><T><L><S><I><P><N><P><S><R><S><Y><T><P><P><T><P><T><T><S><K><L><P><T><I><P><D><W><D><G><R><E><R><V><T><P><P><I><S><E><R><I><Q><L><S><I><H><F><V><N><D><T><S><I><Q><V><S><W><L><S><L><F><T><V><M><A><Y><K><L><T><W><V><K><M><G><H><S><L><V><G><G><I><V><Q><E><R><I><V><S><G><E><K><Q><H><L><S><L><V><N><L><E><P><R><S><T><Y><R><I><C><L><V><P><L><D><A><F><N><Y><R><A><V><E><D><T><I><C><S><E><A><T><T><H><A><S><Y><L><N><N><G><S><N><T><A><S><S><H><E><Q><T><T><S><H><S><M><G><S><P><F><L><L><A><G><L><I><G><G><A><V><I><F><V><L><V><V><L><L><S><V><F><C><W><H><M><H><K><K><G><R><Y><T><S><Q><K><W><K><Y><N><R><G><R><R><K><D><D><Y><C><E><A><G><T><K><K><D><N><S><I><L><E><M><T><E><T><S><F><Q><I><V><S><L><N><N><D><Q><L><L><K><G><D><F><R><L><Q><P><I><Y><T><P><N><G><G><I><N><Y><T><D><C><H><I><P><N><N><M><R><Y><C><N><S><S><V><P><D><L><E><H><C><H><T>
Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.<BOP>
O43155
P0DJI8
SAA1_HUMAN
Serum amyloid protein A(4-101)
Homo
<M><K><L><L><T><G><L><V><F><C><S><L><V><L><G><V><S><S><R><S><F><F><S><F><L><G><E><A><F><D><G><A><R><D><M><W><R><A><Y><S><D><M><R><E><A><N><Y><I><G><S><D><K><Y><F><H><A><R><G><N><Y><D><A><A><K><R><G><P><G><G><V><W><A><A><E><A><I><S><D><A><R><E><N><I><Q><R><F><F><G><H><G><A><E><D><S><L><A><D><Q><A><A><N><E><W><G><R><S><G><K><D><P><N><H><F><R><P><A><G><L><P><E><K><Y>
Major acute phase protein.<BOP>
P0DJI8
Q9BSI4
TINF2_HUMAN
TRF1-interacting nuclear protein 2
Homo
<M><A><T><P><L><V><A><G><P><A><A><L><R><F><A><A><A><A><S><W><Q><V><V><R><G><R><C><V><E><H><F><P><R><V><L><E><F><L><R><S><L><R><A><V><A><P><G><L><V><R><Y><R><H><H><E><R><L><C><M><G><L><K><A><K><V><V><V><E><L><I><L><Q><G><R><P><W><A><Q><V><L><K><A><L><N><H><H><F><P><E><S><G><P><I><V><R><D><P><K><A><T><K><Q><D><L><R><K><I><L><E><A><Q><E><T><F><Y><Q><Q><V><K><Q><L><S><E><A><P><V><D><L><A><S><K><L><Q><E><L><E><Q><E><Y><G><E><P><F><L><A><A><M><E><K><L><L><F><E><Y><L><C><Q><L><E><K><A><L><P><T><P><Q><A><Q><Q><L><Q><D><V><L><S><W><M><Q><P><G><V><S><I><T><S><S><L><A><W><R><Q><Y><G><V><D><M><G><W><L><L><P><E><C><S><V><T><D><S><V><N><L><A><E><P><M><E><Q><N><P><P><Q><Q><Q><R><L><A><L><H><N><P><L><P><K><A><K><P><G><T><H><L><P><Q><G><P><S><S><R><T><H><P><E><P><L><A><G><R><H><F><N><L><A><P><L><G><R><R><R><V><Q><S><Q><W><A><S><T><R><G><G><H><K><E><R><P><T><V><M><L><F><P><F><R><N><L><G><S><P><T><Q><V><I><S><K><P><E><S><K><E><E><H><A><I><Y><T><A><D><L><A><M><G><T><R><A><A><S><T><G><K><S><K><S><P><C><Q><T><L><G><G><R><A><L><K><E><N><P><V><D><L><P><A><T><E><Q><K><E><N><C><L><D><C><Y><M><D><P><L><R><L><S><L><L><P><P><R><A><R><K><P><V><C><P><P><S><L><C><S><S><V><I><T><I><G><D><L><V><L><D><S><D><E><E><E><N><G><Q><G><E><G><K><E><S><L><E><N><Y><Q><K><T><K><F><D><T><L><I><P><T><L><C><E><Y><L><P><P><S><G><H><G><A><I><P><V><S><S><C><D><C><R><D><S><S><R><P><L>
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.<BOP>
Q9BSI4
Q96NU1
SAM11_HUMAN
Sterile alpha motif domain-containing protein 11
Homo
<M><S><K><G><I><L><Q><V><H><P><P><I><C><D><C><P><G><C><R><I><S><S><P><V><N><R><G><R><L><A><D><K><R><T><V><A><L><P><A><A><R><N><L><K><K><E><R><T><P><S><F><S><A><S><D><G><D><S><D><G><S><G><P><T><C><G><R><R><P><G><L><K><Q><E><D><G><P><H><I><R><I><M><K><R><R><V><H><T><H><W><D><V><N><I><S><F><R><E><A><S><C><S><Q><D><G><N><L><P><T><L><I><S><S><V><H><R><S><R><H><L><V><M><P><E><H><Q><S><R><C><E><F><Q><R><G><S><L><E><I><G><L><R><P><A><G><D><L><L><G><K><R><L><G><R><S><P><R><I><S><S><D><C><F><S><E><K><R><A><R><S><E><S><P><Q><E><A><L><L><L><P><R><E><L><G><P><S><M><A><P><E><D><H><Y><R><R><L><V><S><A><L><S><E><A><S><T><F><E><D><P><Q><R><L><Y><H><L><G><L><P><S><H><G><E><D><P><P><W><H><D><P><P><H><H><L><P><S><H><D><L><L><R><V><R><Q><E><V><A><A><A><A><L><R><G><P><S><G><L><E><A><H><L><P><S><S><T><A><G><Q><R><R><K><Q><G><L><A><Q><H><R><E><G><A><A><P><A><A><A><P><S><F><S><E><R><E><L><P><Q><P><P><P><L><L><S><P><Q><N><A><P><H><V><A><L><G><P><H><L><R><P><P><F><L><G><V><P><S><A><L><C><Q><T><P><G><Y><G><F><L><P><P><A><Q><A><E><M><F><A><W><Q><Q><E><L><L><R><K><Q><N><L><A><R><L><E><L><P><A><D><L><L><R><Q><K><E><L><E><S><A><R><P><Q><L><L><A><P><E><T><A><L><R><P><N><D><G><A><E><E><L><Q><R><R><G><A><L><L><V><L><N><H><G><A><A><P><L><L><A><L><P><P><Q><G><P><P><G><S><G><P><P><T><P><S><R><D><S><A><R><R><A><P><R><K><G><G><P><G><P><A><S><A><R><P><S><E><S><K><E><M><T><G><A><R><L><W><A><Q><D><G><S><E><D><E><P><P><K><D><S><D><G><E><D><P><E><T><A><A><V><G><C><R><G><P><T><P><G><Q><A><P><A><G><G><A><G><A><E><G><K><G><L><F><P><G><S><T><L><P><L><G><F><P><Y><A><V><S><P><Y><F><H><T><G><A><V><G><G><L><S><M><D><G><E><E><A><P><A><P><E><D><V><T><K><W><T><V><D><D><V><C><S><F><V><G><G><L><S><G><C><G><E><Y><T><R><V><F><R><E><Q><G><I><D><G><E><T><L><P><L><L><T><E><E><H><L><L><T><N><M><G><L><K><L><G><P><A><L><K><I><R><A><Q><V><A><R><R><L><G><R><V><F><Y><V><A><S><F><P><V><A><L><P><L><Q><P><P><T><L><R><A><P><E><R><E><L><G><T><G><E><Q><P><L><S><P><T><T><A><T><S><P><Y><G><G><G><H><A><L><A><G><Q><T><S><P><K><Q><E><N><G><T><L><A><L><L><P><G><A><P><D><P><S><Q><P><L><C>
May play a role in photoreceptor development.<BOP>
Q96NU1
P42575
CASP2_HUMAN
Caspase-2 subunit p12
Homo
<M><A><A><P><S><A><G><S><W><S><T><F><Q><H><K><E><L><M><A><A><D><R><G><R><R><I><L><G><V><C><G><M><H><P><H><H><Q><E><T><L><K><K><N><R><V><V><L><A><K><Q><L><L><L><S><E><L><L><E><H><L><L><E><K><D><I><I><T><L><E><M><R><E><L><I><Q><A><K><V><G><S><F><S><Q><N><V><E><L><L><N><L><L><P><K><R><G><P><Q><A><F><D><A><F><C><E><A><L><R><E><T><K><Q><G><H><L><E><D><M><L><L><T><T><L><S><G><L><Q><H><V><L><P><P><L><S><C><D><Y><D><L><S><L><P><F><P><V><C><E><S><C><P><L><Y><K><K><L><R><L><S><T><D><T><V><E><H><S><L><D><N><K><D><G><P><V><C><L><Q><V><K><P><C><T><P><E><F><Y><Q><T><H><F><Q><L><A><Y><R><L><Q><S><R><P><R><G><L><A><L><V><L><S><N><V><H><F><T><G><E><K><E><L><E><F><R><S><G><G><D><V><D><H><S><T><L><V><T><L><F><K><L><L><G><Y><D><V><H><V><L><C><D><Q><T><A><Q><E><M><Q><E><K><L><Q><N><F><A><Q><L><P><A><H><R><V><T><D><S><C><I><V><A><L><L><S><H><G><V><E><G><A><I><Y><G><V><D><G><K><L><L><Q><L><Q><E><V><F><Q><L><F><D><N><A><N><C><P><S><L><Q><N><K><P><K><M><F><F><I><Q><A><C><R><G><D><E><T><D><R><G><V><D><Q><Q><D><G><K><N><H><A><G><S><P><G><C><E><E><S><D><A><G><K><E><K><L><P><K><M><R><L><P><T><R><S><D><M><I><C><G><Y><A><C><L><K><G><T><A><A><M><R><N><T><K><R><G><S><W><Y><I><E><A><L><A><Q><V><F><S><E><R><A><C><D><M><H><V><A><D><M><L><V><K><V><N><A><L><I><K><D><R><E><G><Y><A><P><G><T><E><F><H><R><C><K><E><M><S><E><Y><C><S><T><L><C><R><H><L><Y><L><F><P><G><H><P><P><T>
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival . Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress .<BOP>
P42575
Q9P0S3
ORML1_HUMAN
Adoplin-1
Homo
<M><N><V><G><V><A><H><S><E><V><N><P><N><T><R><V><M><N><S><R><G><M><W><L><T><Y><A><L><G><V><G><L><L><H><I><V><L><L><S><I><P><F><F><S><V><P><V><A><W><T><L><T><N><I><I><H><N><L><G><M><Y><V><F><L><H><A><V><K><G><T><P><F><E><T><P><D><Q><G><K><A><R><L><L><T><H><W><E><Q><L><D><Y><G><V><Q><F><T><S><S><R><K><F><F><T><I><S><P><I><I><L><Y><F><L><A><S><F><Y><T><K><Y><D><P><T><H><F><I><L><N><T><A><S><L><L><S><V><L><I><P><K><M><P><Q><L><H><G><V><R><I><F><G><I><N><K><Y>
Negative regulator of sphingolipid synthesis.<BOP>
Q9P0S3
P60022
DEFB1_HUMAN
Defensin, beta 1
Homo
<M><R><T><S><Y><L><L><L><F><T><L><C><L><L><L><S><E><M><A><S><G><G><N><F><L><T><G><L><G><H><R><S><D><H><Y><N><C><V><S><S><G><G><Q><C><L><Y><S><A><C><P><I><F><T><K><I><Q><G><T><C><Y><R><G><K><A><K><C><C><K>
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility .<BOP>
P60022
Q99732
LITAF_HUMAN
p53-induced gene 7 protein
Homo
<M><S><V><P><G><P><Y><Q><A><A><T><G><P><S><S><A><P><S><A><P><P><S><Y><E><E><T><V><A><V><N><S><Y><Y><P><T><P><P><A><P><M><P><G><P><T><T><G><L><V><T><G><P><D><G><K><G><M><N><P><P><S><Y><Y><T><Q><P><A><P><I><P><N><N><N><P><I><T><V><Q><T><V><Y><V><Q><H><P><I><T><F><L><D><R><P><I><Q><M><C><C><P><S><C><N><K><M><I><V><S><Q><L><S><Y><N><A><G><A><L><T><W><L><S><C><G><S><L><C><L><L><G><C><I><A><G><C><C><F><I><P><F><C><V><D><A><L><Q><D><V><D><H><Y><C><P><N><C><R><A><L><L><G><T><Y><K><R><L>
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation . Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades . Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes . Probably plays a role in regulating protein degradation via its interaction with NEDD4 . May also contribute to the regulation of gene expression in the nucleus . Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines . May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 .<BOP>
Q99732
Q8IXE1
OR4N5_HUMAN
Olfactory receptor OR14-33
Homo
<M><E><T><Q><N><L><T><V><V><T><E><F><I><L><L><G><L><T><Q><S><Q><D><A><Q><L><L><V><F><V><L><V><L><I><F><Y><L><I><I><L><P><G><N><F><L><I><I><F><T><I><K><S><D><P><G><L><T><A><P><L><Y><F><F><L><G><N><L><A><L><L><D><A><S><Y><S><F><I><V><V><P><R><M><L><V><D><F><L><S><E><K><K><V><I><S><Y><R><S><C><I><T><Q><L><F><F><L><H><F><L><G><A><G><E><M><F><L><L><V><V><M><A><F><D><R><Y><I><A><I><C><R><P><L><H><Y><S><T><I><M><N><P><R><A><C><Y><A><L><S><L><V><L><W><L><G><G><F><I><H><S><I><V><Q><V><A><L><I><L><H><L><P><F><C><G><P><N><Q><L><D><N><F><F><C><D><V><P><Q><V><I><K><L><A><C><T><N><T><F><V><V><E><L><L><M><V><S><N><S><G><L><L><S><L><L><C><F><L><G><L><L><A><S><Y><A><V><I><L><C><R><I><R><E><H><S><S><E><G><K><S><K><A><I><S><T><C><T><T><H><I><I><I><I><F><L><M><F><G><P><A><I><F><I><Y><T><C><P><F><Q><A><F><P><A><D><K><V><V><S><L><F><H><T><V><I><F><P><L><M><N><P><V><I><Y><T><L><R><N><Q><E><V><K><A><S><M><R><K><L><L><S><Q><H><M><F><C>
Odorant receptor.<BOP>
Q8IXE1
Q86SE8
NPM2_HUMAN
Nucleoplasmin-2
Homo
<M><N><L><S><S><A><S><S><T><E><E><K><A><V><T><T><V><L><W><G><C><E><L><S><Q><E><R><R><T><W><T><F><R><P><Q><L><E><G><K><Q><S><C><R><L><L><L><H><T><I><C><L><G><E><K><A><K><E><E><M><H><R><V><E><I><L><P><P><A><N><Q><E><D><K><K><M><Q><P><V><T><I><A><S><L><Q><A><S><V><L><P><M><V><S><M><V><G><V><Q><L><S><P><P><V><T><F><Q><L><R><A><G><S><G><P><V><F><L><S><G><Q><E><R><Y><E><A><S><D><L><T><W><E><E><E><E><E><E><E><G><E><E><E><E><E><E><E><E><D><D><E><D><E><D><A><D><I><S><L><E><E><Q><S><P><V><K><Q><V><K><R><L><V><P><Q><K><Q><A><S><V><A><K><K><K><K><L><E><K><E><E><E><E><I><R><A><S><V><R><D><K><S><P><V><K><K><A><K><A><T><A><R><A><K><K><P><G><F><K><K>
Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.<BOP>
Q86SE8
A0A0C4DH34
HV428_HUMAN
Immunoglobulin heavy variable 4-28
Homo
<M><K><H><L><W><F><F><L><L><L><V><A><A><P><R><W><V><L><S><Q><V><Q><L><Q><E><S><G><P><G><L><V><K><P><S><D><T><L><S><L><T><C><A><V><S><G><Y><S><I><S><S><S><N><W><W><G><W><I><R><Q><P><P><G><K><G><L><E><W><I><G><Y><I><Y><Y><S><G><S><T><Y><Y><N><P><S><L><K><S><R><V><T><M><S><V><D><T><S><K><N><Q><F><S><L><K><L><S><S><V><T><A><V><D><T><A><V><Y><Y><C><A><R>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0C4DH34
H7C241
CLD34_HUMAN
Claudin-34
Homo
<M><V><W><F><C><N><S><A><D><C><Q><F><S><V><F><A><L><T><T><I><G><W><I><L><S><S><T><S><T><G><L><V><E><W><R><I><W><Y><M><K><D><T><S><L><Y><P><P><G><I><A><C><V><G><I><F><R><V><C><I><Y><R><R><R><T><N><S><T><T><T><K><F><C><Y><R><Y><S><Y><Q><D><T><F><L><P><F><E><I><S><M><A><Q><R><F><L><L><T><A><S><I><F><G><F><F><G><R><A><F><N><M><F><A><L><R><N><M><S><M><R><M><F><E><E><D><T><Y><N><S><F><V><V><S><G><I><L><N><I><A><A><G><V><F><N><L><I><A><V><L><Q><N><Y><D><A><V><I><N><S><Q><G><I><T><F><L><P><S><L><Q><M><P><F><K><P><D><V><Q><E><V><G><T><A><I><Q><V><A><G><I><G><V><L><P><M><L><L><T><G><M><F><S><L><F><Y><K><C><P><P><Y><G><Q><V><H><P><G><I><S><E><M>
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP>
H7C241
Q3MUY2
PIGY_HUMAN
Phosphatidylinositol-glycan biosynthesis class Y protein
Homo
<M><F><L><S><L><P><T><L><T><V><L><I><P><L><V><S><L><A><G><L><F><Y><S><A><S><V><E><E><N><F><P><Q><G><C><T><S><T><A><S><L><C><F><Y><S><L><L><L><P><I><T><I><P><V><Y><V><F><F><H><L><W><T><W><M><G><I><K><L><F><R><H><N>
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis . May act by regulating the catalytic subunit PIGA .<BOP>
Q3MUY2
P58557
YBEY_HUMAN
Endoribonuclease YbeY
Homo
<M><S><L><V><I><R><N><L><Q><R><V><I><P><I><R><R><A><P><L><R><S><K><I><E><I><V><R><R><I><L><G><V><Q><K><F><D><L><G><I><I><C><V><D><N><K><N><I><Q><H><I><N><R><I><Y><R><D><R><N><V><P><T><D><V><L><S><F><P><F><H><E><H><L><K><A><G><E><F><P><Q><P><D><F><P><D><D><Y><N><L><G><D><I><F><L><G><V><E><Y><I><F><H><Q><C><K><E><N><E><D><Y><N><D><V><L><T><V><T><A><T><H><G><L><C><H><L><L><G><F><T><H><G><T><E><A><E><W><Q><Q><M><F><Q><K><E><K><A><V><L><D><E><L><G><R><R><T><G><T><R><L><Q><P><L><T><R><G><L><F><G><G><S>
Single strand-specific metallo-endoribonuclease involved in rRNA maturation.<BOP>
P58557
Q8IYJ0
PIANP_HUMAN
Paired immunoglobin-like type 2 receptor-associating neural protein
Homo
<M><E><S><R><M><W><P><A><L><L><L><S><H><L><L><P><L><W><P><L><L><L><L><P><L><P><P><P><A><Q><G><S><S><S><S><P><R><T><P><P><A><P><A><R><P><P><C><A><R><G><G><P><S><A><P><R><H><V><C><V><W><E><R><A><P><P><P><S><R><S><P><R><V><P><R><S><R><R><Q><V><L><P><G><T><A><P><P><A><T><P><S><G><F><E><E><G><P><P><S><S><Q><Y><P><W><A><I><V><W><G><P><T><V><S><R><E><D><G><G><D><P><N><S><A><N><P><G><F><L><D><Y><G><F><A><A><P><H><G><L><A><T><P><H><P><N><S><D><S><M><R><G><D><G><D><G><L><I><L><G><E><A><P><A><T><L><R><P><F><L><F><G><G><R><G><E><G><V><D><P><Q><L><Y><V><T><I><T><I><S><I><I><I><V><L><V><A><T><G><I><I><F><K><F><C><W><D><R><S><Q><K><R><R><R><P><S><G><Q><Q><G><A><L><R><Q><E><E><S><Q><Q><P><L><T><D><L><S><P><A><G><V><T><V><L><G><A><F><G><D><S><P><T><P><T><P><D><H><E><E><P><R><G><G><P><R><P><G><M><P><H><P><K><G><A><P><A><F><Q><L><N><R><I><P><L><V><N><L>
Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.<BOP>
Q8IYJ0
P30046
DOPD_HUMAN
Phenylpyruvate tautomerase II
Homo
<M><P><F><L><E><L><D><T><N><L><P><A><N><R><V><P><A><G><L><E><K><R><L><C><A><A><A><A><S><I><L><G><K><P><A><D><R><V><N><V><T><V><R><P><G><L><A><M><A><L><S><G><S><T><E><P><C><A><Q><L><S><I><S><S><I><G><V><V><G><T><A><E><D><N><R><S><H><S><A><H><F><F><E><F><L><T><K><E><L><A><L><G><Q><D><R><I><L><I><R><F><F><P><L><E><S><W><Q><I><G><K><I><G><T><V><M><T><F><L>
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).<BOP>
P30046
P0DP08
HVD82_HUMAN
Immunoglobulin heavy variable 4-38-2
Homo
<M><K><H><L><W><F><F><L><L><L><V><A><A><P><R><W><V><L><S><Q><V><Q><L><Q><E><S><G><P><G><L><V><K><P><S><E><T><L><S><L><T><C><T><V><S><G><Y><S><I><S><S><G><Y><Y><W><G><W><I><R><Q><P><P><G><K><G><L><E><W><I><G><S><I><Y><H><S><G><S><T><Y><Y><N><P><S><L><K><S><R><V><T><I><S><V><D><T><S><K><N><Q><F><S><L><K><L><S><S><V><T><A><A><D><T><A><V><Y><Y><C><A><R>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P0DP08
Q8N4N8
KIF2B_HUMAN
Kinesin-like protein KIF2B
Homo
<M><A><S><Q><F><C><L><P><E><S><P><C><L><S><P><L><K><P><L><K><P><H><F><G><D><I><Q><E><G><I><Y><V><A><I><Q><R><S><D><K><R><I><H><L><A><V><V><T><E><I><N><R><E><N><Y><W><V><T><V><E><W><V><E><K><A><V><K><K><G><K><K><I><D><L><E><T><I><L><L><L><N><P><A><L><D><S><A><E><H><P><M><P><P><P><P><L><S><P><L><A><L><A><P><S><S><A><I><R><D><Q><R><T><A><T><K><W><V><A><M><I><P><Q><K><N><Q><T><A><S><G><D><S><L><D><V><R><V><P><S><K><P><C><L><M><K><Q><K><K><S><P><C><L><W><E><I><Q><K><L><Q><E><Q><R><E><K><R><R><R><L><Q><Q><E><I><R><A><R><R><A><L><D><V><N><T><R><N><P><N><Y><E><I><M><H><M><I><E><E><Y><R><R><H><L><D><S><S><K><I><S><V><L><E><P><P><Q><E><H><R><I><C><V><C><V><R><K><R><P><L><N><Q><R><E><T><T><L><K><D><L><D><I><I><T><V><P><S><D><N><V><V><M><V><H><E><S><K><Q><K><V><D><L><T><R><Y><L><Q><N><Q><T><F><C><F><D><H><A><F><D><D><K><A><S><N><E><L><V><Y><Q><F><T><A><Q><P><L><V><E><S><I><F><R><K><G><M><A><T><C><F><A><Y><G><Q><T><G><S><G><K><T><Y><T><M><G><G><D><F><S><G><T><A><Q><D><C><S><K><G><I><Y><A><L><V><A><Q><D><V><F><L><L><L><R><N><S><T><Y><E><K><L><D><L><K><V><Y><G><T><F><F><E><I><Y><G><G><K><V><Y><D><L><L><N><W><K><K><K><L><Q><V><L><E><D><G><N><Q><Q><I><Q><V><V><G><L><Q><E><K><E><V><C><C><V><E><E><V><L><N><L><V><E><I><G><N><S><C><R><T><S><R><Q><T><P><V><N><A><H><S><S><R><S><H><A><V><F><Q><I><I><L><K><S><G><R><I><M><H><G><K><F><S><L><V><D><L><A><G><N><E><R><G><A><D><T><T><K><A><S><R><K><R><Q><L><E><G><A><E><I><N><K><S><L><L><A><L><K><E><C><I><L><A><L><G><Q><N><K><P><H><T><P><F><R><A><S><K><L><T><L><V><L><R><D><S><F><I><G><Q><N><S><S><T><C><M><I><A><T><I><S><P><G><M><T><S><C><E><N><T><L><N><T><L><R><Y><A><N><R><V><K><K><L><N><V><D><V><R><P><Y><H><R><G><H><Y><P><I><G><H><E><A><P><R><M><L><K><S><H><I><G><N><S><E><M><S><L><Q><R><D><E><F><I><K><I><P><Y><V><Q><S><E><E><Q><K><E><I><E><E><V><E><T><L><P><T><L><L><G><K><D><T><T><I><S><G><K><G><S><S><Q><W><L><E><N><I><Q><E><R><A><G><G><V><H><H><D><I><D><F><C><I><A><R><S><L><S><I><L><E><Q><K><I><D><A><L><T><E><I><Q><K><K><L><K><L><L><L><A><D><L><H><V><K><S><K><V><E>
Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity . Plays a role in chromosome congression .<BOP>
Q8N4N8
Q9H892
TTC12_HUMAN
Tetratricopeptide repeat protein 12
Homo
<M><D><A><D><K><E><K><D><L><Q><K><F><L><K><N><V><D><E><I><S><N><L><I><Q><E><M><N><S><D><D><P><V><V><Q><Q><K><A><V><L><E><T><E><K><R><L><L><L><M><E><E><D><Q><E><E><D><E><C><R><T><T><L><N><K><T><M><I><S><P><P><Q><T><A><M><K><S><A><E><E><I><N><S><E><A><F><L><A><S><V><E><K><D><A><K><E><R><A><K><R><R><R><E><N><K><V><L><A><D><A><L><K><E><K><G><N><E><A><F><A><E><G><N><Y><E><T><A><I><L><R><Y><S><E><G><L><E><K><L><K><D><M><K><V><L><Y><T><N><R><A><Q><A><Y><M><K><L><E><D><Y><E><K><A><L><V><D><C><E><W><A><L><K><C><D><E><K><C><T><K><A><Y><F><H><M><G><K><A><N><L><A><L><K><N><Y><S><V><S><R><E><C><Y><K><K><I><L><E><I><N><P><K><L><Q><T><Q><V><K><G><Y><L><N><Q><V><D><L><Q><E><K><A><D><L><Q><E><K><E><A><H><E><L><L><D><S><G><K><N><T><A><V><T><T><K><N><L><L><E><T><L><S><K><P><D><Q><I><P><L><F><Y><A><G><G><I><E><I><L><T><E><M><I><N><E><C><T><E><Q><T><L><F><R><M><H><N><G><F><S><I><I><S><D><N><E><V><I><R><R><C><F><S><T><A><G><N><D><A><V><E><E><M><V><C><V><S><V><L><K><L><W><Q><A><V><C><S><R><N><E><E><N><Q><R><V><L><V><I><H><H><D><R><A><R><L><L><A><A><L><L><S><S><K><V><L><A><I><R><Q><Q><S><F><A><L><L><L><H><L><A><Q><T><E><S><G><R><S><L><I><I><N><H><L><D><L><T><R><L><L><E><A><L><V><S><F><L><D><F><S><D><K><E><A><N><T><A><M><G><L><F><T><D><L><A><L><E><E><R><F><Q><V><W><F><Q><A><N><L><P><G><V><L><P><A><L><T><G><V><L><K><T><D><P><K><V><S><S><S><S><A><L><C><Q><C><I><A><I><M><G><N><L><S><A><E><P><T><T><R><R><H><M><A><A><C><E><E><F><G><D><G><C><L><S><L><L><A><R><C><E><E><D><V><D><L><F><R><E><V><I><Y><T><L><L><G><L><M><M><N><L><C><L><Q><A><P><F><V><S><E><V><W><A><V><E><V><S><R><R><C><L><S><L><L><N><S><Q><D><G><G><I><L><T><R><A><A><G><V><L><S><R><T><L><S><S><S><L><K><I><V><E><E><A><L><R><A><G><V><V><K><K><M><M><K><F><L><K><T><G><G><E><T><A><S><R><Y><A><I><K><I><L><A><I><C><T><N><S><Y><H><E><A><R><E><E><V><I><R><L><D><K><K><L><S><V><M><M><K><L><L><S><S><E><D><E><V><L><V><G><N><A><A><L><C><L><G><N><C><M><E><V><P><N><V><A><S><S><L><L><K><T><D><L><L><Q><V><L><L><K><L><A><G><S><D><T><Q><K><T><A><V><Q><V><N><A><G><I><A><L><G><K><L><C><T><A><E><P><R><F><A><A><Q><L><R><K><L><H><G><L><E><I><L><N><S><T><M><K><Y><I><S><D><S>
Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella.<BOP>
Q9H892
Q9H244
P2Y12_HUMAN
SP1999
Homo
<M><Q><A><V><D><N><L><T><S><A><P><G><N><T><S><L><C><T><R><D><Y><K><I><T><Q><V><L><F><P><L><L><Y><T><V><L><F><F><V><G><L><I><T><N><G><L><A><M><R><I><F><F><Q><I><R><S><K><S><N><F><I><I><F><L><K><N><T><V><I><S><D><L><L><M><I><L><T><F><P><F><K><I><L><S><D><A><K><L><G><T><G><P><L><R><T><F><V><C><Q><V><T><S><V><I><F><Y><F><T><M><Y><I><S><I><S><F><L><G><L><I><T><I><D><R><Y><Q><K><T><T><R><P><F><K><T><S><N><P><K><N><L><L><G><A><K><I><L><S><V><V><I><W><A><F><M><F><L><L><S><L><P><N><M><I><L><T><N><R><Q><P><R><D><K><N><V><K><K><C><S><F><L><K><S><E><F><G><L><V><W><H><E><I><V><N><Y><I><C><Q><V><I><F><W><I><N><F><L><I><V><I><V><C><Y><T><L><I><T><K><E><L><Y><R><S><Y><V><R><T><R><G><V><G><K><V><P><R><K><K><V><N><V><K><V><F><I><I><I><A><V><F><F><I><C><F><V><P><F><H><F><A><R><I><P><Y><T><L><S><Q><T><R><D><V><F><D><C><T><A><E><N><T><L><F><Y><V><K><E><S><T><L><W><L><T><S><L><N><A><C><L><D><P><F><I><Y><F><F><L><C><K><S><F><R><N><S><L><I><S><M><L><K><C><P><N><S><A><T><S><L><S><Q><D><N><R><K><K><E><Q><D><G><G><D><P><N><E><E><T><P><M>
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.<BOP>
Q9H244
Q9Y698
CCG2_HUMAN
Transmembrane AMPAR regulatory protein gamma-2
Homo
<M><G><L><F><D><R><G><V><Q><M><L><L><T><T><V><G><A><F><A><A><F><S><L><M><T><I><A><V><G><T><D><Y><W><L><Y><S><R><G><V><C><K><T><K><S><V><S><E><N><E><T><S><K><K><N><E><E><V><M><T><H><S><G><L><W><R><T><C><C><L><E><G><N><F><K><G><L><C><K><Q><I><D><H><F><P><E><D><A><D><Y><E><A><D><T><A><E><Y><F><L><R><A><V><R><A><S><S><I><F><P><I><L><S><V><I><L><L><F><M><G><G><L><C><I><A><A><S><E><F><Y><K><T><R><H><N><I><I><L><S><A><G><I><F><F><V><S><A><G><L><S><N><I><I><G><I><I><V><Y><I><S><A><N><A><G><D><P><S><K><S><D><S><K><K><N><S><Y><S><Y><G><W><S><F><Y><F><G><A><L><S><F><I><I><A><E><M><V><G><V><L><A><V><H><M><F><I><D><R><H><K><Q><L><R><A><T><A><R><A><T><D><Y><L><Q><A><S><A><I><T><R><I><P><S><Y><R><Y><R><Y><Q><R><R><S><R><S><S><S><R><S><T><E><P><S><H><S><R><D><A><S><P><V><G><I><K><G><F><N><T><L><P><S><T><E><I><S><M><Y><T><L><S><R><D><P><L><K><A><A><T><T><P><T><A><T><Y><N><S><D><R><D><N><S><F><L><Q><V><H><N><C><I><Q><K><E><N><K><D><S><L><H><S><N><T><A><N><R><R><T><T><P><V>
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.<BOP>
Q9Y698
P04181
OAT_HUMAN
Ornithine aminotransferase, renal form
Homo
<M><F><S><K><L><A><H><L><Q><R><F><A><V><L><S><R><G><V><H><S><S><V><A><S><A><T><S><V><A><T><K><K><T><V><Q><G><P><P><T><S><D><D><I><F><E><R><E><Y><K><Y><G><A><H><N><Y><H><P><L><P><V><A><L><E><R><G><K><G><I><Y><L><W><D><V><E><G><R><K><Y><F><D><F><L><S><S><Y><S><A><V><N><Q><G><H><C><H><P><K><I><V><N><A><L><K><S><Q><V><D><K><L><T><L><T><S><R><A><F><Y><N><N><V><L><G><E><Y><E><E><Y><I><T><K><L><F><N><Y><H><K><V><L><P><M><N><T><G><V><E><A><G><E><T><A><C><K><L><A><R><K><W><G><Y><T><V><K><G><I><Q><K><Y><K><A><K><I><V><F><A><A><G><N><F><W><G><R><T><L><S><A><I><S><S><S><T><D><P><T><S><Y><D><G><F><G><P><F><M><P><G><F><D><I><I><P><Y><N><D><L><P><A><L><E><R><A><L><Q><D><P><N><V><A><A><F><M><V><E><P><I><Q><G><E><A><G><V><V><V><P><D><P><G><Y><L><M><G><V><R><E><L><C><T><R><H><Q><V><L><F><I><A><D><E><I><Q><T><G><L><A><R><T><G><R><W><L><A><V><D><Y><E><N><V><R><P><D><I><V><L><L><G><K><A><L><S><G><G><L><Y><P><V><S><A><V><L><C><D><D><D><I><M><L><T><I><K><P><G><E><H><G><S><T><Y><G><G><N><P><L><G><C><R><V><A><I><A><A><L><E><V><L><E><E><E><N><L><A><E><N><A><D><K><L><G><I><I><L><R><N><E><L><M><K><L><P><S><D><V><V><T><A><V><R><G><K><G><L><L><N><A><I><V><I><K><E><T><K><D><W><D><A><W><K><V><C><L><R><L><R><D><N><G><L><L><A><K><P><T><H><G><D><I><I><R><F><A><P><P><L><V><I><K><E><D><E><L><R><E><S><I><E><I><I><N><K><T><I><L><S><F>
Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.<BOP>
P04181
Q53H47
SETMR_HUMAN
Transposon Hsmar1 transposase
Homo
<M><F><A><E><A><A><K><T><T><R><P><C><G><M><A><E><F><K><E><K><P><E><A><P><T><E><Q><L><D><V><A><C><G><Q><E><N><L><P><V><G><A><W><P><P><G><A><A><P><A><P><F><Q><Y><T><P><D><H><V><V><G><P><G><A><D><I><D><P><T><Q><I><T><F><P><G><C><I><C><V><K><T><P><C><L><P><G><T><C><S><C><L><R><H><G><E><N><Y><D><D><N><S><C><L><R><D><I><G><S><G><G><K><Y><A><E><P><V><F><E><C><N><V><L><C><R><C><S><D><H><C><R><N><R><V><V><Q><K><G><L><Q><F><H><F><Q><V><F><K><T><H><K><K><G><W><G><L><R><T><L><E><F><I><P><K><G><R><F><V><C><E><Y><A><G><E><V><L><G><F><S><E><V><Q><R><R><I><H><L><Q><T><K><S><D><S><N><Y><I><I><A><I><R><E><H><V><Y><N><G><Q><V><M><E><T><F><V><D><P><T><Y><I><G><N><I><G><R><F><L><N><H><S><C><E><P><N><L><L><M><I><P><V><R><I><D><S><M><V><P><K><L><A><L><F><A><A><K><D><I><V><P><E><E><E><L><S><Y><D><Y><S><G><R><Y><L><N><L><T><V><S><E><D><K><E><R><L><D><H><G><K><L><R><K><P><C><Y><C><G><A><K><S><C><T><A><F><L><P><F><D><S><S><L><Y><C><P><V><E><K><S><N><I><S><C><G><N><E><K><E><P><S><M><C><G><S><A><P><S><V><F><P><S><C><K><R><L><T><L><E><T><M><K><M><M><L><D><K><K><Q><I><R><A><I><F><L><F><E><F><K><M><G><R><K><A><A><E><T><T><R><N><I><N><N><A><F><G><P><G><T><A><N><E><R><T><V><Q><W><W><F><K><K><F><C><K><G><D><E><S><L><E><D><E><E><R><S><G><R><P><S><E><V><D><N><D><Q><L><R><A><I><I><E><A><D><P><L><T><T><T><R><E><V><A><E><E><L><N><V><N><H><S><T><V><V><R><H><L><K><Q><I><G><K><V><K><K><L><D><K><W><V><P><H><E><L><T><E><N><Q><K><N><R><R><F><E><V><S><S><S><L><I><L><R><N><H><N><E><P><F><L><D><R><I><V><T><C><D><E><K><W><I><L><Y><D><N><R><R><R><S><A><Q><W><L><D><Q><E><E><A><P><K><H><F><P><K><P><I><L><H><P><K><K><V><M><V><T><I><W><W><S><A><A><G><L><I><H><Y><S><F><L><N><P><G><E><T><I><T><S><E><K><Y><A><Q><E><I><D><E><M><N><Q><K><L><Q><R><L><Q><L><A><L><V><N><R><K><G><P><I><L><L><H><D><N><A><R><P><H><V><A><Q><P><T><L><Q><K><L><N><E><L><G><Y><E><V><L><P><H><P><P><Y><S><P><D><L><L><P><T><N><Y><H><V><F><K><H><L><N><N><F><L><Q><G><K><R><F><H><N><Q><Q><D><A><E><N><A><F><Q><E><F><V><E><S><Q><S><T><D><F><Y><A><T><G><I><N><Q><L><I><S><R><W><Q><K><C><V><D><C><N><G><S><Y><F><D>
Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity . In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining . Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A .<BOP>
Q53H47
Q9NXS2
QPCTL_HUMAN
isoQC
Homo
<M><R><S><G><G><R><G><R><P><R><L><R><L><G><E><R><G><L><M><E><P><L><L><P><P><K><R><R><L><L><P><R><V><R><L><L><P><L><L><L><A><L><A><V><G><S><A><F><Y><T><I><W><S><G><W><H><R><R><T><E><E><L><P><L><G><R><E><L><R><V><P><L><I><G><S><L><P><E><A><R><L><R><R><V><V><G><Q><L><D><P><Q><R><L><W><S><T><Y><L><R><P><L><L><V><V><R><T><P><G><S><P><G><N><L><Q><V><R><K><F><L><E><A><T><L><R><S><L><T><A><G><W><H><V><E><L><D><P><F><T><A><S><T><P><L><G><P><V><D><F><G><N><V><V><A><T><L><D><P><R><A><A><R><H><L><T><L><A><C><H><Y><D><S><K><L><F><P><P><G><S><T><P><F><V><G><A><T><D><S><A><V><P><C><A><L><L><L><E><L><A><Q><A><L><D><L><E><L><S><R><A><K><K><Q><A><A><P><V><T><L><Q><L><L><F><L><D><G><E><E><A><L><K><E><W><G><P><K><D><S><L><Y><G><S><R><H><L><A><Q><L><M><E><S><I><P><H><S><P><G><P><T><R><I><Q><A><I><E><L><F><M><L><L><D><L><L><G><A><P><N><P><T><F><Y><S><H><F><P><R><T><V><R><W><F><H><R><L><R><S><I><E><K><R><L><H><R><L><N><L><L><Q><S><H><P><Q><E><V><M><Y><F><Q><P><G><E><P><F><G><S><V><E><D><D><H><I><P><F><L><R><R><G><V><P><V><L><H><L><I><S><T><P><F><P><A><V><W><H><T><P><A><D><T><E><V><N><L><H><P><P><T><V><H><N><L><C><R><I><L><A><V><F><L><A><E><Y><L><G><L>
Responsible for the biosynthesis of pyroglutamyl peptides.<BOP>
Q9NXS2
A0A087X0M5
TVB18_HUMAN
T cell receptor beta variable 18
Homo
<M><D><T><R><L><L><C><C><A><V><I><C><L><L><G><A><G><L><S><N><A><G><V><M><Q><N><P><R><H><L><V><R><R><R><G><Q><E><A><R><L><R><C><S><P><M><K><G><H><S><H><V><Y><W><Y><R><Q><L><P><E><E><G><L><K><F><M><V><Y><L><Q><K><E><N><I><I><D><E><S><G><M><P><K><E><R><F><S><A><E><F><P><K><E><G><P><S><I><L><R><I><Q><Q><V><V><R><G><D><S><A><A><Y><F><C><A><S><S><P>
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A087X0M5
P26022
PTX3_HUMAN
Tumor necrosis factor-inducible gene 14 protein
Homo
<M><H><L><L><A><I><L><F><C><A><L><W><S><A><V><L><A><E><N><S><D><D><Y><D><L><M><Y><V><N><L><D><N><E><I><D><N><G><L><H><P><T><E><D><P><T><P><C><A><C><G><Q><E><H><S><E><W><D><K><L><F><I><M><L><E><N><S><Q><M><R><E><R><M><L><L><Q><A><T><D><D><V><L><R><G><E><L><Q><R><L><R><E><E><L><G><R><L><A><E><S><L><A><R><P><C><A><P><G><A><P><A><E><A><R><L><T><S><A><L><D><E><L><L><Q><A><T><R><D><A><G><R><R><L><A><R><M><E><G><A><E><A><Q><R><P><E><E><A><G><R><A><L><A><A><V><L><E><E><L><R><Q><T><R><A><D><L><H><A><V><Q><G><W><A><A><R><S><W><L><P><A><G><C><E><T><A><I><L><F><P><M><R><S><K><K><I><F><G><S><V><H><P><V><R><P><M><R><L><E><S><F><S><A><C><I><W><V><K><A><T><D><V><L><N><K><T><I><L><F><S><Y><G><T><K><R><N><P><Y><E><I><Q><L><Y><L><S><Y><Q><S><I><V><F><V><V><G><G><E><E><N><K><L><V><A><E><A><M><V><S><L><G><R><W><T><H><L><C><G><T><W><N><S><E><E><G><L><T><S><L><W><V><N><G><E><L><A><A><T><T><V><E><M><A><T><G><H><I><V><P><E><G><G><I><L><Q><I><G><Q><E><K><N><G><C><C><V><G><G><G><F><D><E><T><L><A><F><S><G><R><L><T><G><F><N><I><W><D><S><V><L><S><N><E><E><I><R><E><T><G><G><A><E><S><C><H><I><R><G><N><I><V><G><W><G><V><T><E><I><Q><P><H><G><G><A><Q><Y><V><S>
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.<BOP>
P26022
P11712
CP2C9_HUMAN
S-mephenytoin 4-hydroxylase
Homo
<M><D><S><L><V><V><L><V><L><C><L><S><C><L><L><L><L><S><L><W><R><Q><S><S><G><R><G><K><L><P><P><G><P><T><P><L><P><V><I><G><N><I><L><Q><I><G><I><K><D><I><S><K><S><L><T><N><L><S><K><V><Y><G><P><V><F><T><L><Y><F><G><L><K><P><I><V><V><L><H><G><Y><E><A><V><K><E><A><L><I><D><L><G><E><E><F><S><G><R><G><I><F><P><L><A><E><R><A><N><R><G><F><G><I><V><F><S><N><G><K><K><W><K><E><I><R><R><F><S><L><M><T><L><R><N><F><G><M><G><K><R><S><I><E><D><R><V><Q><E><E><A><R><C><L><V><E><E><L><R><K><T><K><A><S><P><C><D><P><T><F><I><L><G><C><A><P><C><N><V><I><C><S><I><I><F><H><K><R><F><D><Y><K><D><Q><Q><F><L><N><L><M><E><K><L><N><E><N><I><K><I><L><S><S><P><W><I><Q><I><C><N><N><F><S><P><I><I><D><Y><F><P><G><T><H><N><K><L><L><K><N><V><A><F><M><K><S><Y><I><L><E><K><V><K><E><H><Q><E><S><M><D><M><N><N><P><Q><D><F><I><D><C><F><L><M><K><M><E><K><E><K><H><N><Q><P><S><E><F><T><I><E><S><L><E><N><T><A><V><D><L><F><G><A><G><T><E><T><T><S><T><T><L><R><Y><A><L><L><L><L><L><K><H><P><E><V><T><A><K><V><Q><E><E><I><E><R><V><I><G><R><N><R><S><P><C><M><Q><D><R><S><H><M><P><Y><T><D><A><V><V><H><E><V><Q><R><Y><I><D><L><L><P><T><S><L><P><H><A><V><T><C><D><I><K><F><R><N><Y><L><I><P><K><G><T><T><I><L><I><S><L><T><S><V><L><H><D><N><K><E><F><P><N><P><E><M><F><D><P><H><H><F><L><D><E><G><G><N><F><K><K><S><K><Y><F><M><P><F><S><A><G><K><R><I><C><V><G><E><A><L><A><G><M><E><L><F><L><F><L><T><S><I><L><Q><N><F><N><L><K><S><L><V><D><P><K><N><L><D><T><T><P><V><V><N><G><F><A><S><V><P><P><F><Y><Q><L><C><F><I><P><V>
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis . Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 . Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) . Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol
P11712
Q9BZE4
GTPB4_HUMAN
Nucleolar GTP-binding protein 1
Homo
<M><A><H><Y><N><F><K><K><I><T><V><V><P><S><A><K><D><F><I><D><L><T><L><S><K><T><Q><R><K><T><P><T><V><I><H><K><H><Y><Q><I><H><R><I><R><H><F><Y><M><R><K><V><K><F><T><Q><Q><N><Y><H><D><R><L><S><Q><I><L><T><D><F><P><K><L><D><D><I><H><P><F><Y><A><D><L><M><N><I><L><Y><D><K><D><H><Y><K><L><A><L><G><Q><I><N><I><A><K><N><L><V><D><N><V><A><K><D><Y><V><R><L><M><K><Y><G><D><S><L><Y><R><C><K><Q><L><K><R><A><A><L><G><R><M><C><T><V><I><K><R><Q><K><Q><S><L><E><Y><L><E><Q><V><R><Q><H><L><S><R><L><P><T><I><D><P><N><T><R><T><L><L><L><C><G><Y><P><N><V><G><K><S><S><F><I><N><K><V><T><R><A><D><V><D><V><Q><P><Y><A><F><T><T><K><S><L><F><V><G><H><M><D><Y><K><Y><L><R><W><Q><V><V><D><T><P><G><I><L><D><H><P><L><E><D><R><N><T><I><E><M><Q><A><I><T><A><L><A><H><L><R><A><A><V><L><Y><V><M><D><L><S><E><Q><C><G><H><G><L><R><E><Q><L><E><L><F><Q><N><I><R><P><L><F><I><N><K><P><L><I><V><V><A><N><K><C><D><V><K><R><I><A><E><L><S><E><D><D><Q><K><I><F><T><D><L><Q><S><E><G><F><P><V><I><E><T><S><T><L><T><E><E><G><V><I><K><V><K><T><E><A><C><D><R><L><L><A><H><R><V><E><T><K><M><K><G><N><K><V><N><E><V><L><N><R><L><H><L><A><I><P><T><R><R><D><D><K><E><R><P><P><F><I><P><E><G><V><V><A><R><R><K><R><M><E><T><E><E><S><R><K><K><R><E><R><D><L><E><L><E><M><G><D><D><Y><I><L><D><L><Q><K><Y><W><D><L><M><N><L><S><E><K><H><D><K><I><P><E><I><W><E><G><H><N><I><A><D><Y><I><D><P><A><I><M><K><K><L><E><E><L><E><K><E><E><E><L><R><T><A><A><G><E><Y><D><S><V><S><E><S><E><D><E><E><M><L><E><I><R><Q><L><A><K><Q><I><R><E><K><K><K><L><K><I><L><E><S><K><E><K><N><T><Q><G><P><R><M><P><R><T><A><K><K><V><Q><R><T><V><L><E><K><E><M><R><S><L><G><V><D><M><D><D><K><D><D><A><H><Y><A><V><Q><A><R><R><S><R><S><I><T><R><K><R><K><R><E><D><S><A><P><P><S><S><V><A><R><S><G><S><C><S><R><T><P><R><D><V><S><G><L><R><D><V><K><M><V><K><K><A><K><T><M><M><K><N><A><Q><K><K><M><N><R><L><G><K><K><G><E><A><D><R><H><V><F><D><M><K><P><K><H><L><L><S><G><K><R><K><A><G><K><K><D><R><R>
Involved in the biogenesis of the 60S ribosomal subunit.<BOP>
Q9BZE4
P20062
TCO2_HUMAN
Transcobalamin II
Homo
<M><R><H><L><G><A><F><L><F><L><L><G><V><L><G><A><L><T><E><M><C><E><I><P><E><M><D><S><H><L><V><E><K><L><G><Q><H><L><L><P><W><M><D><R><L><S><L><E><H><L><N><P><S><I><Y><V><G><L><R><L><S><S><L><Q><A><G><T><K><E><D><L><Y><L><H><S><L><K><L><G><Y><Q><Q><C><L><L><G><S><A><F><S><E><D><D><G><D><C><Q><G><K><P><S><M><G><Q><L><A><L><Y><L><L><A><L><R><A><N><C><E><F><V><R><G><H><K><G><D><R><L><V><S><Q><L><K><W><F><L><E><D><E><K><R><A><I><G><H><D><H><K><G><H><P><H><T><S><Y><Y><Q><Y><G><L><G><I><L><A><L><C><L><H><Q><K><R><V><H><D><S><V><V><D><K><L><L><Y><A><V><E><P><F><H><Q><G><H><H><S><V><D><T><A><A><M><A><G><L><A><F><T><C><L><K><R><S><N><F><N><P><G><R><R><Q><R><I><T><M><A><I><R><T><V><R><E><E><I><L><K><A><Q><T><P><E><G><H><F><G><N><V><Y><S><T><P><L><A><L><Q><F><L><M><T><S><P><M><R><G><A><E><L><G><T><A><C><L><K><A><R><V><A><L><L><A><S><L><Q><D><G><A><F><Q><N><A><L><M><I><S><Q><L><L><P><V><L><N><H><K><T><Y><I><D><L><I><F><P><D><C><L><A><P><R><V><M><L><E><P><A><A><E><T><I><P><Q><T><Q><E><I><I><S><V><T><L><Q><V><L><S><L><L><P><P><Y><R><Q><S><I><S><V><L><A><G><S><T><V><E><D><V><L><K><K><A><H><E><L><G><G><F><T><Y><E><T><Q><A><S><L><S><G><P><Y><L><T><S><V><M><G><K><A><A><G><E><R><E><F><W><Q><L><L><R><D><P><N><T><P><L><L><Q><G><I><A><D><Y><R><P><K><D><G><E><T><I><E><L><R><L><V><S><W>
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.<BOP>
P20062
Q96LD8
SENP8_HUMAN
Sentrin/SUMO-specific protease SENP8
Homo
<M><D><P><V><V><L><S><Y><M><D><S><L><L><R><Q><S><D><V><S><L><L><D><P><P><S><W><L><N><D><H><I><I><G><F><A><F><E><Y><F><A><N><S><Q><F><H><D><C><S><D><H><V><S><F><I><S><P><E><V><T><Q><F><I><K><C><T><S><N><P><A><E><I><A><M><F><L><E><P><L><D><L><P><N><K><R><V><V><F><L><A><I><N><D><N><S><N><Q><A><A><G><G><T><H><W><S><L><L><V><Y><L><Q><D><K><N><S><F><F><H><Y><D><S><H><S><R><S><N><S><V><H><A><K><Q><V><A><E><K><L><E><A><F><L><G><R><K><G><D><K><L><A><F><V><E><E><K><A><P><A><Q><Q><N><S><Y><D><C><G><M><Y><V><I><C><N><T><E><A><L><C><Q><N><F><F><R><Q><Q><T><E><S><L><L><Q><L><L><T><P><A><Y><I><T><K><K><R><G><E><W><K><D><L><I><T><T><L><A><K><K>
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.<BOP>
Q96LD8
P49810
PSN2_HUMAN
Presenilin-2 CTF subunit
Homo
<M><L><T><F><M><A><S><D><S><E><E><E><V><C><D><E><R><T><S><L><M><S><A><E><S><P><T><P><R><S><C><Q><E><G><R><Q><G><P><E><D><G><E><N><T><A><Q><W><R><S><Q><E><N><E><E><D><G><E><E><D><P><D><R><Y><V><C><S><G><V><P><G><R><P><P><G><L><E><E><E><L><T><L><K><Y><G><A><K><H><V><I><M><L><F><V><P><V><T><L><C><M><I><V><V><V><A><T><I><K><S><V><R><F><Y><T><E><K><N><G><Q><L><I><Y><T><P><F><T><E><D><T><P><S><V><G><Q><R><L><L><N><S><V><L><N><T><L><I><M><I><S><V><I><V><V><M><T><I><F><L><V><V><L><Y><K><Y><R><C><Y><K><F><I><H><G><W><L><I><M><S><S><L><M><L><L><F><L><F><T><Y><I><Y><L><G><E><V><L><K><T><Y><N><V><A><M><D><Y><P><T><L><L><L><T><V><W><N><F><G><A><V><G><M><V><C><I><H><W><K><G><P><L><V><L><Q><Q><A><Y><L><I><M><I><S><A><L><M><A><L><V><F><I><K><Y><L><P><E><W><S><A><W><V><I><L><G><A><I><S><V><Y><D><L><V><A><V><L><C><P><K><G><P><L><R><M><L><V><E><T><A><Q><E><R><N><E><P><I><F><P><A><L><I><Y><S><S><A><M><V><W><T><V><G><M><A><K><L><D><P><S><S><Q><G><A><L><Q><L><P><Y><D><P><E><M><E><E><D><S><Y><D><S><F><G><E><P><S><Y><P><E><V><F><E><P><P><L><T><G><Y><P><G><E><E><L><E><E><E><E><E><R><G><V><K><L><G><L><G><D><F><I><F><Y><S><V><L><V><G><K><A><A><A><T><G><S><G><D><W><N><T><T><L><A><C><F><V><A><I><L><I><G><L><C><L><T><L><L><L><L><A><V><F><K><K><A><L><P><A><L><P><I><S><I><T><F><G><L><I><F><Y><F><S><T><D><N><L><V><R><P><F><M><D><T><L><A><S><H><Q><L><Y><I>
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis . Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria .<BOP>
P49810
Q14953
KI2S5_HUMAN
Natural killer-associated transcript 9
Homo
<M><S><L><M><V><I><S><M><A><C><V><A><F><F><L><L><Q><G><A><W><P><H><E><G><F><R><R><K><P><S><L><L><A><H><P><G><P><L><V><K><S><E><E><T><V><I><L><Q><C><W><S><D><V><M><F><E><H><F><L><L><H><R><E><G><T><F><N><H><T><L><R><L><I><G><E><H><I><D><G><V><S><K><G><N><F><S><I><G><R><M><T><Q><D><L><A><G><T><Y><R><C><Y><G><S><V><T><H><S><P><Y><Q><L><S><A><P><S><D><P><L><D><I><V><I><T><G><L><Y><E><K><P><S><L><S><A><Q><P><G><P><T><V><L><A><G><E><S><V><T><L><S><C><S><S><R><S><S><Y><D><M><Y><H><L><S><R><E><G><E><A><H><E><R><R><L><P><A><G><P><K><V><N><R><T><F><Q><A><D><F><P><L><D><P><A><T><H><G><G><T><Y><R><C><F><G><S><F><R><D><S><P><Y><E><W><S><K><S><S><D><P><L><L><V><S><V><T><G><N><S><S><N><S><W><P><S><P><T><E><P><S><S><E><T><G><N><P><R><H><L><H><V><L><I><G><T><S><V><V><K><L><P><F><T><I><L><L><F><F><L><L><H><R><W><C><S><N><K><K><N><A><S><V><M><D><Q><G><P><A><G><N><R><T><V><N><R><E><D><S><D><E><Q><D><H><Q><E><V><S><Y><A>
Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity . Able to activate NK cells citotoxicity and cytokine production such as IFNG . Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry .<BOP>
Q14953
P01569
IFNA5_HUMAN
Interferon alpha-G
Homo
<M><A><L><P><F><V><L><L><M><A><L><V><V><L><N><C><K><S><I><C><S><L><G><C><D><L><P><Q><T><H><S><L><S><N><R><R><T><L><M><I><M><A><Q><M><G><R><I><S><P><F><S><C><L><K><D><R><H><D><F><G><F><P><Q><E><E><F><D><G><N><Q><F><Q><K><A><Q><A><I><S><V><L><H><E><M><I><Q><Q><T><F><N><L><F><S><T><K><D><S><S><A><T><W><D><E><T><L><L><D><K><F><Y><T><E><L><Y><Q><Q><L><N><D><L><E><A><C><M><M><Q><E><V><G><V><E><D><T><P><L><M><N><V><D><S><I><L><T><V><R><K><Y><F><Q><R><I><T><L><Y><L><T><E><K><K><Y><S><P><C><A><W><E><V><V><R><A><E><I><M><R><S><F><S><L><S><A><N><L><Q><E><R><L><R><R><K><E>
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<BOP>
P01569
Q15782
CH3L2_HUMAN
YKL-39
Homo
<M><G><A><T><T><M><D><Q><K><S><L><W><A><G><V><V><V><L><L><L><L><Q><G><G><S><A><Y><K><L><V><C><Y><F><T><N><W><S><Q><D><R><Q><E><P><G><K><F><T><P><E><N><I><D><P><F><L><C><S><H><L><I><Y><S><F><A><S><I><E><N><N><K><V><I><I><K><D><K><S><E><V><M><L><Y><Q><T><I><N><S><L><K><T><K><N><P><K><L><K><I><L><L><S><I><G><G><Y><L><F><G><S><K><G><F><H><P><M><V><D><S><S><T><S><R><L><E><F><I><N><S><I><I><L><F><L><R><N><H><N><F><D><G><L><D><V><S><W><I><Y><P><D><Q><K><E><N><T><H><F><T><V><L><I><H><E><L><A><E><A><F><Q><K><D><F><T><K><S><T><K><E><R><L><L><L><T><A><G><V><S><A><G><R><Q><M><I><D><N><S><Y><Q><V><E><K><L><A><K><D><L><D><F><I><N><L><L><S><F><D><F><H><G><S><W><E><K><P><L><I><T><G><H><N><S><P><L><S><K><G><W><Q><D><R><G><P><S><S><Y><Y><N><V><E><Y><A><V><G><Y><W><I><H><K><G><M><P><S><E><K><V><V><M><G><I><P><T><Y><G><H><S><F><T><L><A><S><A><E><T><T><V><G><A><P><A><S><G><P><G><A><A><G><P><I><T><E><S><S><G><F><L><A><Y><Y><E><I><C><Q><F><L><K><G><A><K><I><T><R><L><Q><D><Q><Q><V><P><Y><A><V><K><G><N><Q><W><V><G><Y><D><D><V><K><S><M><E><T><K><V><Q><F><L><K><N><L><N><L><G><G><A><M><I><W><S><I><D><M><D><D><F><T><G><K><S><C><N><Q><G><P><Y><P><L><V><Q><A><V><K><R><S><L><G><S><L>
Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.<BOP>
Q15782
Q13163
MP2K5_HUMAN
MAPK/ERK kinase 5
Homo
<M><L><W><L><A><L><G><P><F><P><A><M><E><N><Q><V><L><V><I><R><I><K><I><P><N><S><G><A><V><D><W><T><V><H><S><G><P><Q><L><L><F><R><D><V><L><D><V><I><G><Q><V><L><P><E><A><T><T><T><A><F><E><Y><E><D><E><D><G><D><R><I><T><V><R><S><D><E><E><M><K><A><M><L><S><Y><Y><Y><S><T><V><M><E><Q><Q><V><N><G><Q><L><I><E><P><L><Q><I><F><P><R><A><C><K><P><P><G><E><R><N><I><H><G><L><K><V><N><T><R><A><G><P><S><Q><H><S><S><P><A><V><S><D><S><L><P><S><N><S><L><K><K><S><S><A><E><L><K><K><I><L><A><N><G><Q><M><N><E><Q><D><I><R><Y><R><D><T><L><G><H><G><N><G><G><T><V><Y><K><A><Y><H><V><P><S><G><K><I><L><A><V><K><V><I><L><L><D><I><T><L><E><L><Q><K><Q><I><M><S><E><L><E><I><L><Y><K><C><D><S><S><Y><I><I><G><F><Y><G><A><F><F><V><E><N><R><I><S><I><C><T><E><F><M><D><G><G><S><L><D><V><Y><R><K><M><P><E><H><V><L><G><R><I><A><V><A><V><V><K><G><L><T><Y><L><W><S><L><K><I><L><H><R><D><V><K><P><S><N><M><L><V><N><T><R><G><Q><V><K><L><C><D><F><G><V><S><T><Q><L><V><N><S><I><A><K><T><Y><V><G><T><N><A><Y><M><A><P><E><R><I><S><G><E><Q><Y><G><I><H><S><D><V><W><S><L><G><I><S><F><M><E><L><A><L><G><R><F><P><Y><P><Q><I><Q><K><N><Q><G><S><L><M><P><L><Q><L><L><Q><C><I><V><D><E><D><S><P><V><L><P><V><G><E><F><S><E><P><F><V><H><F><I><T><Q><C><M><R><K><Q><P><K><E><R><P><A><P><E><E><L><M><G><H><P><F><I><V><Q><F><N><D><G><N><A><A><V><V><S><M><W><V><C><R><A><L><E><E><R><R><S><Q><Q><G><P><P>
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<BOP>
Q13163
Q6BDI9
REP15_HUMAN
Rab15 effector protein
Homo
<M><G><Q><K><A><S><Q><Q><L><A><L><K><D><S><K><E><V><P><V><V><C><E><V><V><S><E><A><I><V><H><A><A><Q><K><L><K><E><Y><L><G><F><E><Y><P><P><S><K><L><C><P><A><A><N><T><L><N><E><I><F><L><I><H><F><I><T><F><C><Q><E><K><G><V><D><E><W><L><T><T><T><K><M><T><K><H><Q><A><F><L><F><G><A><D><W><I><W><T><F><W><G><S><N><K><Q><I><K><L><Q><L><A><V><Q><T><L><Q><M><S><S><P><P><P><V><E><S><K><P><C><D><L><S><N><P><E><S><R><V><E><E><S><S><W><K><K><S><R><F><D><K><L><E><E><F><C><N><L><I><G><E><D><C><L><G><L><F><I><I><F><G><M><P><G><K><P><K><D><I><R><G><V><V><L><D><S><V><K><S><Q><M><V><R><S><H><L><P><G><G><K><A><V><A><Q><F><V><L><E><T><E><D><C><V><F><I><K><E><L><L><R><N><C><L><S><K><K><D><G><L><R><E><V><G><K><V><Y><I><S><I><L>
Regulates transferrin receptor recycling from the endocytic recycling compartment.<BOP>
Q6BDI9
Q9NQX0
PRDM6_HUMAN
PR domain-containing protein 6
Homo
<M><L><K><P><G><D><P><G><G><S><A><F><L><K><V><D><P><A><Y><L><Q><H><W><Q><Q><L><F><P><H><G><G><A><G><P><L><K><G><S><G><A><A><G><L><L><S><A><P><Q><P><L><Q><P><P><P><P><P><P><P><P><E><R><A><E><P><P><P><D><S><L><R><P><R><P><A><S><L><S><S><A><S><S><T><P><A><S><S><S><T><S><A><S><S><A><S><S><C><A><A><A><A><A><A><A><A><L><A><G><L><S><A><L><P><V><S><Q><L><P><V><F><A><P><L><A><A><A><A><V><A><A><E><P><L><P><P><K><E><L><C><L><G><A><T><S><G><P><G><P><V><K><C><G><G><G><G><G><G><G><G><E><G><R><G><A><P><R><F><R><C><S><A><E><E><L><D><Y><Y><L><Y><G><Q><Q><R><M><E><I><I><P><L><N><Q><H><T><S><D><P><N><N><R><C><D><M><C><A><D><N><R><N><G><E><C><P><M><H><G><P><L><H><S><L><R><R><L><V><G><T><S><S><A><A><A><A><A><P><P><P><E><L><P><E><W><L><R><D><L><P><R><E><V><C><L><C><T><S><T><V><P><G><L><A><Y><G><I><C><A><A><Q><R><I><Q><Q><G><T><W><I><G><P><F><Q><G><V><L><L><P><P><E><K><V><Q><A><G><A><V><R><N><T><Q><H><L><W><E><I><Y><D><Q><D><G><T><L><Q><H><F><I><D><G><G><E><P><S><K><S><S><W><M><R><Y><I><R><C><A><R><H><C><G><E><Q><N><L><T><V><V><Q><Y><R><S><N><I><F><Y><R><A><C><I><D><I><P><R><G><T><E><L><L><V><W><Y><N><D><S><Y><T><S><F><F><G><I><P><L><Q><C><I><A><Q><D><E><N><L><N><V><P><S><T><V><M><E><A><M><C><R><Q><D><A><L><Q><P><F><N><K><S><S><K><L><A><P><T><T><Q><Q><R><S><V><V><F><P><Q><T><P><C><S><R><N><F><S><L><L><D><K><S><G><P><I><E><S><G><F><N><Q><I><N><V><K><N><Q><R><V><L><A><S><P><T><S><T><S><Q><L><H><S><E><F><S><D><W><H><L><W><K><C><G><Q><C><F><K><T><F><T><Q><R><I><L><L><Q><M><H><V><C><T><Q><N><P><D><R><P><Y><Q><C><G><H><C><S><Q><S><F><S><Q><P><S><E><L><R><N><H><V><V><T><H><S><S><D><R><P><F><K><C><G><Y><C><G><R><A><F><A><G><A><T><T><L><N><N><H><I><R><T><H><T><G><E><K><P><F><K><C><E><R><C><E><R><S><F><T><Q><A><T><Q><L><S><R><H><Q><R><M><P><N><E><C><K><P><I><T><E><S><P><E><S><I><E><V><D>
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.<BOP>
Q9NQX0
Q9NQS3
NECT3_HUMAN
Poliovirus receptor-related protein 3
Homo
<M><A><R><T><L><R><P><S><P><L><C><P><G><G><G><K><A><Q><L><S><S><A><S><L><L><G><A><G><L><L><L><Q><P><P><T><P><P><P><L><L><L><L><L><F><P><L><L><L><F><S><R><L><C><G><A><L><A><G><P><I><I><V><E><P><H><V><T><A><V><W><G><K><N><V><S><L><K><C><L><I><E><V><N><E><T><I><T><Q><I><S><W><E><K><I><H><G><K><S><S><Q><T><V><A><V><H><H><P><Q><Y><G><F><S><V><Q><G><E><Y><Q><G><R><V><L><F><K><N><Y><S><L><N><D><A><T><I><T><L><H><N><I><G><F><S><D><S><G><K><Y><I><C><K><A><V><T><F><P><L><G><N><A><Q><S><S><T><T><V><T><V><L><V><E><P><T><V><S><L><I><K><G><P><D><S><L><I><D><G><G><N><E><T><V><A><A><I><C><I><A><A><T><G><K><P><V><A><H><I><D><W><E><G><D><L><G><E><M><E><S><T><T><T><S><F><P><N><E><T><A><T><I><I><S><Q><Y><K><L><F><P><T><R><F><A><R><G><R><R><I><T><C><V><V><K><H><P><A><L><E><K><D><I><R><Y><S><F><I><L><D><I><Q><Y><A><P><E><V><S><V><T><G><Y><D><G><N><W><F><V><G><R><K><G><V><N><L><K><C><N><A><D><A><N><P><P><P><F><K><S><V><W><S><R><L><D><G><Q><W><P><D><G><L><L><A><S><D><N><T><L><H><F><V><H><P><L><T><F><N><Y><S><G><V><Y><I><C><K><V><T><N><S><L><G><Q><R><S><D><Q><K><V><I><Y><I><S><D><P><P><T><T><T><T><L><Q><P><T><I><Q><W><H><P><S><T><A><D><I><E><D><L><A><T><E><P><K><K><L><P><F><P><L><S><T><L><A><T><I><K><D><D><T><I><A><T><I><I><A><S><V><V><G><G><A><L><F><I><V><L><V><S><V><L><A><G><I><F><C><Y><R><R><R><R><T><F><R><G><D><Y><F><A><K><N><Y><I><P><P><S><D><M><Q><K><E><S><Q><I><D><V><L><Q><Q><D><E><L><D><S><Y><P><D><S><V><K><K><E><N><K><N><P><V><N><N><L><I><R><K><D><Y><L><E><E><P><E><K><T><Q><W><N><N><V><E><N><L><N><R><F><E><R><P><M><D><Y><Y><E><D><L><K><M><G><M><K><F><V><S><D><E><H><Y><D><E><N><E><D><D><L><V><S><H><V><D><G><S><V><I><S><R><R><E><W><Y><V>
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.<BOP>
Q9NQS3
Q9NUQ3
TXLNG_HUMAN
Lipopolysaccharide-specific response protein 5
Homo
<M><A><T><R><V><E><E><A><A><R><G><R><G><G><G><A><E><E><A><T><E><A><G><R><G><G><R><R><R><S><P><R><Q><K><F><E><I><G><T><M><E><E><A><G><I><C><G><L><G><V><K><A><D><M><L><C><N><S><Q><S><N><D><I><L><Q><H><Q><G><S><N><C><G><G><T><S><N><K><H><S><L><E><E><D><E><G><S><D><F><I><T><E><N><R><N><L><V><S><P><A><Y><C><T><Q><E><S><R><E><E><I><P><G><G><E><A><R><T><D><P><P><D><G><Q><Q><D><S><E><C><N><R><N><K><E><K><T><L><G><K><E><V><L><L><L><M><Q><A><L><N><T><L><S><T><P><E><E><K><L><A><A><L><C><K><K><Y><A><D><L><L><E><E><S><R><S><V><Q><K><Q><M><K><I><L><Q><K><K><Q><A><Q><I><V><K><E><K><V><H><L><Q><S><E><H><S><K><A><I><L><A><R><S><K><L><E><S><L><C><R><E><L><Q><R><H><N><K><T><L><K><E><E><N><M><Q><Q><A><R><E><E><E><E><R><R><K><E><A><T><A><H><F><Q><I><T><L><N><E><I><Q><A><Q><L><E><Q><H><D><I><H><N><A><K><L><R><Q><E><N><I><E><L><G><E><K><L><K><K><L><I><E><Q><Y><A><L><R><E><E><H><I><D><K><V><F><K><H><K><E><L><Q><Q><Q><L><V><D><A><K><L><Q><Q><T><T><Q><L><I><K><E><A><D><E><K><H><Q><R><E><R><E><F><L><L><K><E><A><T><E><S><R><H><K><Y><E><Q><M><K><Q><Q><E><V><Q><L><K><Q><Q><L><S><L><Y><M><D><K><F><E><E><F><Q><T><T><M><A><K><S><N><E><L><F><T><T><F><R><Q><E><M><E><K><M><T><K><K><I><K><K><L><E><K><E><T><I><I><W><R><T><K><W><E><N><N><N><K><A><L><L><Q><M><A><E><E><K><T><V><R><D><K><E><Y><K><A><L><Q><I><K><L><E><R><L><E><K><L><C><R><A><L><Q><T><E><R><N><E><L><N><E><K><V><E><V><L><K><E><Q><V><S><I><K><A><A><I><K><A><A><N><R><D><L><A><T><P><V><M><Q><P><C><T><A><L><D><S><H><K><E><L><N><T><S><S><K><R><A><L><G><A><H><L><E><A><E><P><K><S><Q><R><S><A><V><Q><K><P><P><S><T><G><S><A><P><A><I><E><S><V><D>
May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.<BOP>
Q9NUQ3
O75679
RFPL3_HUMAN
Ret finger protein-like 3
Homo
<M><K><R><L><S><L><V><T><T><N><R><L><S><P><Q><G><N><F><L><P><L><C><T><F><P><L><A><V><D><M><A><A><L><F><Q><E><A><S><S><C><P><V><C><S><D><Y><L><E><K><P><M><S><L><E><C><G><C><T><V><C><L><K><C><I><N><S><L><Q><K><E><P><H><G><E><D><L><L><C><C><C><C><S><M><V><S><Q><R><N><K><I><R><P><N><R><Q><L><E><R><L><V><S><H><I><K><E><L><E><P><K><L><K><K><I><L><Q><M><N><P><R><M><R><K><F><Q><V><D><M><T><L><D><A><D><T><A><N><N><F><L><L><I><S><D><D><L><R><S><V><R><S><G><L><I><T><Q><N><R><Q><D><L><A><E><R><F><D><V><S><V><C><I><L><G><S><P><R><F><T><C><G><R><H><Y><W><E><V><D><V><G><T><S><T><E><W><D><L><G><V><C><R><E><S><V><H><C><K><G><K><I><Q><L><T><T><E><L><G><F><W><T><V><S><L><R><D><G><S><R><L><S><A><S><T><V><P><L><T><F><L><L><V><D><R><K><L><Q><R><V><G><I><F><L><D><M><G><M><Q><N><V><S><F><F><D><A><E><S><G><S><H><V><Y><T><F><R><S><V><S><A><E><E><P><L><R><P><F><L><A><P><S><I><P><P><N><G><D><Q><G><V><L><S><I><C><P><L><M><N><S><G><T><T><D><A><P><V><R><P><G><E><A><K>
(Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.<BOP>
O75679
Q9H4Q3
PRD13_HUMAN
PR domain-containing protein 13
Homo
<M><H><G><A><A><R><A><P><A><T><S><V><S><A><D><C><C><I><P><A><G><L><R><L><G><P><V><P><G><T><F><K><L><G><K><Y><L><S><D><R><R><E><P><G><P><K><K><K><V><R><M><V><R><G><E><L><V><D><E><S><G><G><S><P><L><E><W><I><G><L><I><R><A><A><R><N><S><Q><E><Q><T><L><E><A><I><A><D><L><P><G><G><Q><I><F><Y><R><A><L><R><D><V><Q><P><G><E><E><L><T><V><W><Y><S><N><S><L><A><Q><W><F><D><I><P><T><T><A><T><P><T><H><D><E><K><G><E><E><R><Y><I><C><W><Y><C><W><R><T><F><R><Y><P><N><S><L><K><A><H><L><R><F><H><C><V><F><S><G><G><G><G><G><A><F><L><H><H><E><H><A><A><R><Q><G><A><V><P><A><A><D><G><L><G><L><S><P><K><P><P><A><P><D><F><A><A><P><S><Q><A><G><T><L><R><P><H><P><L><G><P><P><P><V><Q><A><C><G><A><R><E><G><I><K><R><E><A><S><S><A><P><S><A><T><S><P><T><P><G><K><W><G><Q><P><K><K><G><K><E><Q><L><D><R><A><L><D><M><S><G><A><A><R><G><Q><G><H><F><L><G><I><V><G><G><S><S><A><G><V><G><S><L><A><F><Y><P><G><V><R><S><A><F><K><P><A><G><L><A><R><A><A><A><A><A><H><G><D><P><Y><R><E><E><S><S><S><K><Q><G><A><G><L><A><L><G><R><L><L><G><G><G><R><A><C><G><R><P><G><S><G><E><N><S><A><A><G><G><A><G><H><H><H><H><H><H><A><H><H><H><H><H><P><K><C><L><L><A><G><D><P><P><P><P><P><P><P><G><L><P><C><S><G><A><L><R><G><F><P><L><L><S><V><P><P><E><E><A><S><A><F><K><H><V><E><R><A><P><P><A><A><A><A><L><P><G><A><R><Y><A><Q><L><P><P><A><P><G><L><P><L><E><R><C><A><L><P><P><L><D><P><G><G><L><K><A><Y><P><G><G><E><C><S><H><L><P><A><V><M><P><A><F><T><V><Y><N><G><E><L><L><Y><G><S><P><A><T><T><A><Y><Y><P><L><K><L><H><F><G><G><L><L><K><Y><P><E><S><I><S><Y><F><S><G><P><A><A><A><A><L><S><P><A><E><L><G><S><L><A><S><I><D><R><E><I><A><M><H><N><Q><Q><L><S><E><M><A><A><G><K><G><R><G><R><L><D><S><G><T><L><P><P><A><V><A><A><A><G><G><T><G><G><G><G><S><G><G><S><G><A><G><K><P><K><T><G><H><L><C><L><Y><C><G><K><L><Y><S><R><K><Y><G><L><K><I><H><M><R><T><H><T><G><Y><K><P><L><K><C><K><V><C><L><R><P><F><G><D><P><S><N><L><N><K><H><I><R><L><H><A><E><G><N><T><P><Y><R><C><E><F><C><G><K><V><L><V><R><R><R><D><L><E><R><H><V><K><S><R><H><P><G><Q><S><L><L><A><K><A><G><D><G><P><G><A><E><P><G><Y><P><P><E><P><G><D><P><K><S><D><D><S><D><V><D><V><C><F><T><D><D><Q><S><D><P><E><V><G><G><G><G><E><R><D><L>
May be involved in transcriptional regulation.<BOP>
Q9H4Q3
Q96MW5
COG8_HUMAN
Component of oligomeric Golgi complex 8
Homo
<M><A><T><A><A><T><I><P><S><V><A><T><A><T><A><A><A><L><G><E><V><E><D><E><G><L><L><A><S><L><F><R><D><R><F><P><E><A><Q><W><R><E><R><P><D><V><G><R><Y><L><R><E><L><S><G><S><G><L><E><R><L><R><R><E><P><E><R><L><A><E><E><R><A><Q><L><L><Q><Q><T><R><D><L><A><F><A><N><Y><K><T><F><I><R><G><A><E><C><T><E><R><I><H><R><L><F><G><D><V><E><A><S><L><G><R><L><L><D><R><L><P><S><F><Q><Q><S><C><R><N><F><V><K><E><A><E><E><I><S><S><N><R><R><M><N><S><L><T><L><N><R><H><T><E><I><L><E><I><L><E><I><P><Q><L><M><D><T><C><V><R><N><S><Y><Y><E><E><A><L><E><L><A><A><Y><V><R><R><L><E><R><K><Y><S><S><I><P><V><I><Q><G><I><V><N><E><V><R><Q><S><M><Q><L><M><L><S><Q><L><I><Q><Q><L><R><T><N><I><Q><L><P><A><C><L><R><V><I><G><Y><L><R><R><M><D><V><F><T><E><A><E><L><R><V><K><F><L><Q><A><R><D><A><W><L><R><S><I><L><T><A><I><P><N><D><D><P><Y><F><H><I><T><K><T><I><E><A><S><R><V><H><L><F><D><I><I><T><Q><Y><R><A><I><F><S><D><E><D><P><L><L><P><P><A><M><G><E><H><T><V><N><E><S><A><I><F><H><G><W><V><L><Q><K><V><S><Q><F><L><Q><V><L><E><T><D><L><Y><R><G><I><G><G><H><L><D><S><L><L><G><Q><C><M><Y><F><G><L><S><F><S><R><V><G><A><D><F><R><G><Q><L><A><P><V><F><Q><R><V><A><I><S><T><F><Q><K><A><I><Q><E><T><V><E><K><F><Q><E><E><M><N><S><Y><M><L><I><S><A><P><A><I><L><G><T><S><N><M><P><A><A><V><P><A><T><Q><P><G><T><L><Q><P><P><M><V><L><L><D><F><P><P><L><A><C><F><L><N><N><I><L><V><A><F><N><D><L><R><L><C><C><P><V><A><L><A><Q><D><V><T><G><A><L><E><D><A><L><A><K><V><T><K><I><I><L><A><F><H><R><A><E><E><A><A><F><S><S><G><E><Q><E><L><F><V><Q><F><C><T><V><F><L><E><D><L><V><P><Y><L><N><R><C><L><Q><V><L><F><P><P><A><Q><I><A><Q><T><L><G><I><P><P><T><Q><L><S><K><Y><G><N><L><G><H><V><N><I><G><A><I><Q><E><P><L><A><F><I><L><P><K><R><E><T><L><F><T><L><D><D><Q><A><L><G><P><E><L><T><A><P><A><P><E><P><P><A><E><E><P><R><L><E><P><A><G><P><A><C><P><E><G><G><R><A><E><T><Q><A><E><P><P><S><V><G><P>
Required for normal Golgi function.<BOP>
Q96MW5
Q6IFH4
OR6B2_HUMAN
Olfactory receptor OR2-1
Homo
<M><S><G><E><N><V><T><K><V><S><T><F><I><L><V><G><L><P><T><A><P><G><L><Q><Y><L><L><F><L><L><F><L><L><T><Y><L><F><V><L><V><E><N><L><A><I><I><L><I><V><W><S><S><T><S><L><H><R><P><M><Y><Y><F><L><S><S><M><S><F><L><E><I><W><Y><V><S><D><I><T><P><K><M><L><E><G><F><L><L><Q><Q><K><R><I><S><F><V><G><C><M><T><Q><L><Y><F><F><S><S><L><V><C><T><E><C><V><L><L><A><S><M><A><Y><D><R><Y><V><A><I><C><H><P><L><R><Y><H><V><L><V><T><P><G><L><C><L><Q><L><V><G><F><S><F><V><S><G><F><T><I><S><M><I><K><V><C><F><I><S><S><V><T><F><C><G><S><N><V><L><N><H><F><F><C><D><I><S><P><I><L><K><L><A><C><T><D><F><S><T><A><E><L><V><D><F><I><L><A><F><I><I><L><V><F><P><L><L><A><T><I><L><S><Y><W><H><I><T><L><A><V><L><R><I><P><S><A><T><G><C><W><R><A><F><S><T><C><A><S><H><L><T><V><V><T><V><F><Y><T><A><L><L><F><M><Y><V><R><P><Q><A><I><D><S><Q><S><S><N><K><L><I><S><A><V><Y><T><V><V><T><P><I><I><N><P><L><I><Y><C><L><R><N><K><E><F><K><D><A><L><K><K><A><L><G><L><G><Q><T><S><H>
Odorant receptor.<BOP>
Q6IFH4
Q8NHV1
GIMA7_HUMAN
Immunity-associated nucleotide 7 protein
Homo
<M><A><E><S><E><D><R><S><L><R><I><V><L><V><G><K><T><G><S><G><K><S><A><T><A><N><T><I><L><G><E><E><I><F><D><S><R><I><A><A><Q><A><V><T><K><N><C><Q><K><A><S><R><E><W><Q><G><R><D><L><L><V><V><D><T><P><G><L><F><D><T><K><E><S><L><D><T><T><C><K><E><I><S><R><C><I><I><S><S><C><P><G><P><H><A><I><V><L><V><L><L><L><G><R><Y><T><E><E><E><Q><K><T><V><A><L><I><K><A><V><F><G><K><S><A><M><K><H><M><V><I><L><F><T><R><K><E><E><L><E><G><Q><S><F><H><D><F><I><A><D><A><D><V><G><L><K><S><I><V><K><E><C><G><N><R><C><C><A><F><S><N><S><K><K><T><S><K><A><E><K><E><S><Q><V><Q><E><L><V><E><L><I><E><K><M><V><Q><C><N><E><G><A><Y><F><S><D><D><I><Y><K><D><T><E><E><R><L><K><Q><R><E><E><V><L><R><K><I><Y><T><D><Q><L><N><E><E><I><K><L><V><E><E><D><K><H><K><S><E><E><E><K><E><K><E><I><K><L><L><K><L><K><Y><D><E><K><I><K><N><I><R><E><E><A><E><R><N><I><F><K><D><V><F><N><R><I><W><K><M><L><S><E><I><W><H><R><F><L><S><K><C><K><F><Y><S><S>
The dimer has GTPase activity; the active site contains residues from both subunits.<BOP>
Q8NHV1
Q96PC2
IP6K3_HUMAN
Inositol hexaphosphate kinase 3
Homo
<M><V><V><Q><N><S><A><D><A><G><D><M><R><A><G><V><Q><L><E><P><F><L><H><Q><V><G><G><H><M><S><V><M><K><Y><D><E><H><T><V><C><K><P><L><V><S><R><E><Q><R><F><Y><E><S><L><P><L><A><M><K><R><F><T><P><Q><Y><K><G><T><V><T><V><H><L><W><K><D><S><T><G><H><L><S><L><V><A><N><P><V><K><E><S><Q><E><P><F><K><V><S><T><E><S><A><A><V><A><I><W><Q><T><L><Q><Q><T><T><G><S><N><G><S><D><C><T><L><A><Q><W><P><H><A><Q><L><A><R><S><P><K><E><S><P><A><K><A><L><L><R><S><E><P><H><L><N><T><P><A><F><S><L><V><E><D><T><N><G><N><Q><V><E><R><K><S><F><N><P><W><G><L><Q><C><H><Q><A><H><L><T><R><L><C><S><E><Y><P><E><N><K><R><H><R><F><L><L><L><E><N><V><V><S><Q><Y><T><H><P><C><V><L><D><L><K><M><G><T><R><Q><H><G><D><D><A><S><E><E><K><K><A><R><H><M><R><K><C><A><Q><S><T><S><A><C><L><G><V><R><I><C><G><M><Q><V><Y><Q><T><D><K><K><Y><F><L><C><K><D><K><Y><Y><G><R><K><L><S><V><E><G><F><R><Q><A><L><Y><Q><F><L><H><N><G><S><H><L><R><R><E><L><L><E><P><I><L><H><Q><L><R><A><L><L><S><V><I><R><S><Q><S><S><Y><R><F><Y><S><S><S><L><L><V><I><Y><D><G><Q><E><P><P><E><R><A><P><G><S><P><H><P><H><E><A><P><Q><A><A><H><G><S><S><P><G><G><L><T><K><V><D><I><R><M><I><D><F><A><H><T><T><Y><K><G><Y><W><N><E><H><T><T><Y><D><G><P><D><P><G><Y><I><F><G><L><E><N><L><I><R><I><L><Q><D><I><Q><E><G><E>
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.<BOP>
Q96PC2