accession
stringlengths 6
10
| name
stringlengths 8
11
| Full Name
stringlengths 2
102
⌀ | taxon
stringclasses 1
value | sequence
stringlengths 48
2.3k
| function
stringlengths 15
1.34k
| AlphaFoldDB
stringlengths 6
10
|
|---|---|---|---|---|---|---|
Q9UBD6
|
RHCG_HUMAN
|
Tumor-related protein DRC2
|
Homo
|
<M><A><W><N><T><N><L><R><W><R><L><P><L><T><C><L><L><L><Q><V><I><M><V><I><L><F><G><V><F><V><R><Y><D><F><E><A><D><A><H><W><W><S><E><R><T><H><K><N><L><S><D><M><E><N><E><F><Y><Y><R><Y><P><S><F><Q><D><V><H><V><M><V><F><V><G><F><G><F><L><M><T><F><L><Q><R><Y><G><F><S><A><V><G><F><N><F><L><L><A><A><F><G><I><Q><W><A><L><L><M><Q><G><W><F><H><F><L><Q><D><R><Y><I><V><V><G><V><E><N><L><I><N><A><D><F><C><V><A><S><V><C><V><A><F><G><A><V><L><G><K><V><S><P><I><Q><L><L><I><M><T><F><F><Q><V><T><L><F><A><V><N><E><F><I><L><L><N><L><L><K><V><K><D><A><G><G><S><M><T><I><H><T><F><G><A><Y><F><G><L><T><V><T><R><I><L><Y><R><R><N><L><E><Q><S><K><E><R><Q><N><S><V><Y><Q><S><D><L><F><A><M><I><G><T><L><F><L><W><M><Y><W><P><S><F><N><S><A><I><S><Y><H><G><D><S><Q><H><R><A><A><I><N><T><Y><C><S><L><A><A><C><V><L><T><S><V><A><I><S><S><A><L><H><K><K><G><K><L><D><M><V><H><I><Q><N><A><T><L><A><G><G><V><A><V><G><T><A><A><E><M><M><L><M><P><Y><G><A><L><I><I><G><F><V><C><G><I><I><S><T><L><G><F><V><Y><L><T><P><F><L><E><S><R><L><H><I><Q><D><T><C><G><I><N><N><L><H><G><I><P><G><I><I><G><G><I><V><G><A><V><T><A><A><S><A><S><L><E><V><Y><G><K><E><G><L><V><H><S><F><D><F><Q><G><F><N><G><D><W><T><A><R><T><Q><G><K><F><Q><I><Y><G><L><L><V><T><L><A><M><A><L><M><G><G><I><I><V><G><L><I><L><R><L><P><F><W><G><Q><P><S><D><E><N><C><F><E><D><A><V><Y><W><E><M><P><E><G><N><S><T><V><Y><I><P><E><D><P><T><F><K><P><S><G><P><S><V><P><S><V><P><M><V><S><P><L><P><M><A><S><S><V><P><L><V><P>
|
Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.<BOP>
|
Q9UBD6
|
A0A075B6H7
|
KV37_HUMAN
|
Probable non-functional immunoglobulin kappa variable 3-7
|
Homo
|
<M><E><A><P><A><Q><L><L><F><L><L><L><L><W><L><P><D><T><T><R><E><I><V><M><T><Q><S><P><P><T><L><S><L><S><P><G><E><R><V><T><L><S><C><R><A><S><Q><S><V><S><S><S><Y><L><T><W><Y><Q><Q><K><P><G><Q><A><P><R><L><L><I><Y><G><A><S><T><R><A><T><S><I><P><A><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><P><E><D><F><A><V><Y><Y><C><Q><Q><D><Y><N><L><P>
|
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection
|
A0A075B6H7
|
O75943
|
RAD17_HUMAN
|
RF-C/activator 1 homolog
|
Homo
|
<M><S><K><T><F><L><R><P><K><V><S><S><T><K><V><T><D><W><V><D><P><S><F><D><D><F><L><E><C><S><G><V><S><T><I><T><A><T><S><L><G><V><N><N><S><S><H><R><R><K><N><G><P><S><T><L><E><S><S><R><F><P><A><R><K><R><G><N><L><S><S><L><E><Q><I><Y><G><L><E><N><S><K><E><Y><L><S><E><N><E><P><W><V><D><K><Y><K><P><E><T><Q><H><E><L><A><V><H><K><K><K><I><E><E><V><E><T><W><L><K><A><Q><V><L><E><R><Q><P><K><Q><G><G><S><I><L><L><I><T><G><P><P><G><C><G><K><T><T><T><L><K><I><L><S><K><E><H><G><I><Q><V><Q><E><W><I><N><P><V><L><P><D><F><Q><K><D><D><F><K><G><M><F><N><T><E><S><S><F><H><M><F><P><Y><Q><S><Q><I><A><V><F><K><E><F><L><L><R><A><T><K><Y><N><K><L><Q><M><L><G><D><D><L><R><T><D><K><K><I><I><L><V><E><D><L><P><N><Q><F><Y><R><D><S><H><T><L><H><E><V><L><R><K><Y><V><R><I><G><R><C><P><L><I><F><I><I><S><D><S><L><S><G><D><N><N><Q><R><L><L><F><P><K><E><I><Q><E><E><C><S><I><S><N><I><S><F><N><P><V><A><P><T><I><M><M><K><F><L><N><R><I><V><T><I><E><A><N><K><N><G><G><K><I><T><V><P><D><K><T><S><L><E><L><L><C><Q><G><C><S><G><D><I><R><S><A><I><N><S><L><Q><F><S><S><S><K><G><E><N><N><L><R><P><R><K><K><G><M><S><L><K><S><D><A><V><L><S><K><S><K><R><R><K><K><P><D><R><V><F><E><N><Q><E><V><Q><A><I><G><G><K><D><V><S><L><F><L><F><R><A><L><G><K><I><L><Y><C><K><R><A><S><L><T><E><L><D><S><P><R><L><P><S><H><L><S><E><Y><E><R><D><T><L><L><V><E><P><E><E><V><V><E><M><S><H><M><P><G><D><L><F><N><L><Y><L><H><Q><N><Y><I><D><F><F><M><E><I><D><D><I><V><R><A><S><E><F><L><S><F><A><D><I><L><S><G><D><W><N><T><R><S><L><L><R><E><Y><S><T><S><I><A><T><R><G><V><M><H><S><N><K><A><R><G><Y><A><H><C><Q><G><G><G><S><S><F><R><P><L><H><K><P><Q><W><F><L><I><N><K><K><Y><R><E><N><C><L><A><A><K><A><L><F><P><D><F><C><L><P><A><L><C><L><Q><T><Q><L><L><P><Y><L><A><L><L><T><I><P><M><R><N><Q><A><Q><I><S><F><I><Q><D><I><G><R><L><P><L><K><R><H><F><G><R><L><K><M><E><A><L><T><D><R><E><H><G><M><I><D><P><D><S><G><D><E><A><Q><L><N><G><G><H><S><A><E><E><S><L><G><E><P><T><Q><A><T><V><P><E><T><W><S><L><P><L><S><Q><N><S><A><S><E><L><P><A><S><Q><P><Q><P><F><S><A><Q><G><D><M><E><E><N><I><I><I><E><D><Y><E><S><D><G><T>
|
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.<BOP>
|
O75943
|
P15090
|
FABP4_HUMAN
|
Fatty acid-binding protein 4
|
Homo
|
<M><C><D><A><F><V><G><T><W><K><L><V><S><S><E><N><F><D><D><Y><M><K><E><V><G><V><G><F><A><T><R><K><V><A><G><M><A><K><P><N><M><I><I><S><V><N><G><D><V><I><T><I><K><S><E><S><T><F><K><N><T><E><I><S><F><I><L><G><Q><E><F><D><E><V><T><A><D><D><R><K><V><K><S><T><I><T><L><D><G><G><V><L><V><H><V><Q><K><W><D><G><K><S><T><T><I><K><R><K><R><E><D><D><K><L><V><V><E><C><V><M><K><G><V><T><S><T><R><V><Y><E><R><A>
|
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.<BOP>
|
P15090
|
Q9BVM4
|
GGACT_HUMAN
|
Gamma-glutamylamine cyclotransferase
|
Homo
|
<M><A><L><V><F><V><Y><G><T><L><K><R><G><Q><P><N><H><R><V><L><R><D><G><A><H><G><S><A><A><F><R><A><R><G><R><T><L><E><P><Y><P><L><V><I><A><G><E><H><N><I><P><W><L><L><H><L><P><G><S><G><R><L><V><E><G><E><V><Y><A><V><D><E><R><M><L><R><F><L><D><D><F><E><S><C><P><A><L><Y><Q><R><T><V><L><R><V><Q><L><L><E><D><R><A><P><G><A><E><E><P><P><A><P><T><A><V><Q><C><F><V><Y><S><R><A><T><F><P><P><E><W><A><Q><L><P><H><H><D><S><Y><D><S><E><G><P><H><G><L><R><Y><N><P><R><E><N><R>
|
Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.<BOP>
|
Q9BVM4
|
Q03721
|
KCNC4_HUMAN
|
Voltage-gated potassium channel subunit Kv3.4
|
Homo
|
<M><I><S><S><V><C><V><S><S><Y><R><G><R><K><S><G><N><K><P><P><S><K><T><C><L><K><E><E><M><A><K><G><E><A><S><E><K><I><I><I><N><V><G><G><T><R><H><E><T><Y><R><S><T><L><R><T><L><P><G><T><R><L><A><W><L><A><D><P><D><G><G><G><R><P><E><T><D><G><G><G><V><G><S><S><G><S><S><G><G><G><G><C><E><F><F><F><D><R><H><P><G><V><F><A><Y><V><L><N><Y><Y><R><T><G><K><L><H><C><P><A><D><V><C><G><P><L><F><E><E><E><L><T><F><W><G><I><D><E><T><D><V><E><P><C><C><W><M><T><Y><R><Q><H><R><D><A><E><E><A><L><D><I><F><E><S><P><D><G><G><G><S><G><A><G><P><S><D><E><A><G><D><D><E><R><E><L><A><L><Q><R><L><G><P><H><E><G><G><A><G><H><G><A><G><S><G><G><C><R><G><W><Q><P><R><M><W><A><L><F><E><D><P><Y><S><S><R><A><A><R><V><V><A><F><A><S><L><F><F><I><L><V><S><I><T><T><F><C><L><E><T><H><E><A><F><N><I><D><R><N><V><T><E><I><L><R><V><G><N><I><T><S><V><H><F><R><R><E><V><E><T><E><P><I><L><T><Y><I><E><G><V><C><V><L><W><F><T><L><E><F><L><V><R><I><V><C><C><P><D><T><L><D><F><V><K><N><L><L><N><I><I><D><F><V><A><I><L><P><F><Y><L><E><V><G><L><S><G><L><S><S><K><A><A><R><D><V><L><G><F><L><R><V><V><R><F><V><R><I><L><R><I><F><K><L><T><R><H><F><V><G><L><R><V><L><G><H><T><L><R><A><S><T><N><E><F><L><L><L><I><I><F><L><A><L><G><V><L><I><F><A><T><M><I><Y><Y><A><E><R><I><G><A><R><P><S><D><P><R><G><N><D><H><T><D><F><K><N><I><P><I><G><F><W><W><A><V><V><T><M><T><T><L><G><Y><G><D><M><Y><P><K><T><W><S><G><M><L><V><G><A><L><C><A><L><A><G><V><L><T><I><A><M><P><V><P><V><I><V><N><N><F><G><M><Y><Y><S><L><A><M><A><K><Q><K><L><P><K><K><R><K><K><H><V><P><R><P><A><Q><L><E><S><P><M><Y><C><K><S><E><E><T><S><P><R><D><S><T><C><S><D><T><S><P><P><A><R><E><E><G><M><I><E><R><K><R><A><D><S><K><Q><N><G><D><A><N><A><V><L><S><D><E><E><G><A><G><L><T><Q><P><L><A><S><S><P><T><P><E><E><R><R><A><L><R><R><S><T><T><R><D><R><N><K><K><A><A><A><C><F><L><L><S><T><G><D><Y><A><C><A><D><G><S><V><R><K><G><T><F><V><L><R><D><L><P><L><Q><H><S><P><E><A><A><C><P><P><T><A><G><T><L><F><L><P><H>
|
This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.<BOP>
|
Q03721
|
Q8N1K5
|
THMS1_HUMAN
|
Thymocyte-expressed molecule involved in selection
|
Homo
|
<M><A><L><S><L><E><E><F><V><H><S><L><D><L><R><T><L><P><R><V><L><E><I><Q><A><G><I><Y><L><E><G><S><I><Y><E><M><F><G><N><E><C><C><F><S><T><G><E><V><I><K><I><T><G><L><K><V><K><K><I><I><A><E><I><C><E><Q><I><E><G><C><E><S><L><Q><P><F><E><L><P><M><N><F><P><G><L><F><K><I><V><A><D><K><T><P><Y><L><T><M><E><E><I><T><R><T><I><H><I><G><P><S><R><L><G><H><P><C><F><Y><H><Q><K><D><I><K><L><E><N><L><I><I><K><Q><G><E><Q><I><M><L><N><S><V><E><E><I><D><G><E><I><M><V><S><C><A><V><A><R><N><H><Q><T><H><S><F><N><L><P><L><S><Q><E><G><E><F><Y><E><C><E><D><E><R><I><Y><T><L><K><E><I><V><E><W><K><I><P><K><N><R><T><R><T><V><N><L><T><D><F><S><N><K><W><D><S><T><N><P><F><P><K><D><F><Y><G><T><L><I><L><K><P><V><Y><E><I><Q><G><V><M><K><F><R><K><D><I><I><R><I><L><P><S><L><D><V><E><V><K><D><I><T><D><S><Y><D><A><N><W><F><L><Q><L><L><S><T><E><D><L><F><E><M><T><S><K><E><F><P><I><V><T><E><V><I><E><A><P><E><G><N><H><L><P><Q><S><I><L><Q><P><G><K><T><I><V><I><H><K><K><Y><Q><A><S><R><I><L><A><S><E><I><R><S><N><F><P><K><R><H><F><L><I><P><T><S><Y><K><G><K><F><K><R><R><P><R><E><F><P><T><A><Y><D><L><E><I><A><K><S><E><K><E><P><L><H><V><V><A><T><K><A><F><H><S><P><H><D><K><L><S><S><V><S><V><G><D><Q><F><L><V><H><Q><S><E><T><T><E><V><L><C><E><G><I><K><K><V><V><N><V><L><A><C><E><K><I><L><K><K><S><Y><E><A><A><L><L><P><L><Y><M><E><G><G><F><V><E><V><I><H><D><K><K><Q><Y><P><I><S><E><L><C><K><Q><F><R><L><P><F><N><V><K><V><S><V><R><D><L><S><I><E><E><D><V><L><A><A><T><P><G><L><Q><L><E><E><D><I><T><D><S><Y><L><L><I><S><D><F><A><N><P><T><E><C><W><E><I><P><V><G><R><L><N><M><T><V><Q><L><V><S><N><F><S><R><D><A><E><P><F><L><V><R><T><L><V><E><E><I><T><E><E><Q><Y><Y><M><M><R><R><Y><E><S><S><A><S><H><P><P><P><R><P><P><K><H><P><S><V><E><E><T><K><L><T><L><L><T><L><A><E><E><R><T><V><D><L><P><K><S><P><K><R><H><H><V><D><I><T><K><K><L><H><P><N><Q><A><G><L><D><S><K><V><L><I><G><S><Q><N><D><L><V><D><E><E><K><E><R><S><N><R><G><A><T><A><I><A><E><T><F><K><N><E><K><H><Q><K>
|
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.<BOP>
|
Q8N1K5
|
Q14145
|
KEAP1_HUMAN
|
Kelch-like protein 19
|
Homo
|
<M><Q><P><D><P><R><P><S><G><A><G><A><C><C><R><F><L><P><L><Q><S><Q><C><P><E><G><A><G><D><A><V><M><Y><A><S><T><E><C><K><A><E><V><T><P><S><Q><H><G><N><R><T><F><S><Y><T><L><E><D><H><T><K><Q><A><F><G><I><M><N><E><L><R><L><S><Q><Q><L><C><D><V><T><L><Q><V><K><Y><Q><D><A><P><A><A><Q><F><M><A><H><K><V><V><L><A><S><S><S><P><V><F><K><A><M><F><T><N><G><L><R><E><Q><G><M><E><V><V><S><I><E><G><I><H><P><K><V><M><E><R><L><I><E><F><A><Y><T><A><S><I><S><M><G><E><K><C><V><L><H><V><M><N><G><A><V><M><Y><Q><I><D><S><V><V><R><A><C><S><D><F><L><V><Q><Q><L><D><P><S><N><A><I><G><I><A><N><F><A><E><Q><I><G><C><V><E><L><H><Q><R><A><R><E><Y><I><Y><M><H><F><G><E><V><A><K><Q><E><E><F><F><N><L><S><H><C><Q><L><V><T><L><I><S><R><D><D><L><N><V><R><C><E><S><E><V><F><H><A><C><I><N><W><V><K><Y><D><C><E><Q><R><R><F><Y><V><Q><A><L><L><R><A><V><R><C><H><S><L><T><P><N><F><L><Q><M><Q><L><Q><K><C><E><I><L><Q><S><D><S><R><C><K><D><Y><L><V><K><I><F><E><E><L><T><L><H><K><P><T><Q><V><M><P><C><R><A><P><K><V><G><R><L><I><Y><T><A><G><G><Y><F><R><Q><S><L><S><Y><L><E><A><Y><N><P><S><D><G><T><W><L><R><L><A><D><L><Q><V><P><R><S><G><L><A><G><C><V><V><G><G><L><L><Y><A><V><G><G><R><N><N><S><P><D><G><N><T><D><S><S><A><L><D><C><Y><N><P><M><T><N><Q><W><S><P><C><A><P><M><S><V><P><R><N><R><I><G><V><G><V><I><D><G><H><I><Y><A><V><G><G><S><H><G><C><I><H><H><N><S><V><E><R><Y><E><P><E><R><D><E><W><H><L><V><A><P><M><L><T><R><R><I><G><V><G><V><A><V><L><N><R><L><L><Y><A><V><G><G><F><D><G><T><N><R><L><N><S><A><E><C><Y><Y><P><E><R><N><E><W><R><M><I><T><A><M><N><T><I><R><S><G><A><G><V><C><V><L><H><N><C><I><Y><A><A><G><G><Y><D><G><Q><D><Q><L><N><S><V><E><R><Y><D><V><E><T><E><T><W><T><F><V><A><P><M><K><H><R><R><S><A><L><G><I><T><V><H><Q><G><R><I><Y><V><L><G><G><Y><D><G><H><T><F><L><D><S><V><E><C><Y><D><P><D><T><D><T><W><S><E><V><T><R><M><T><S><G><R><S><G><V><G><V><A><V><T><M><E><P><C><R><K><Q><I><D><Q><Q><N><C><T><C>
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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination . KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes . In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes . In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 . The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1
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Q14145
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P32121
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ARRB2_HUMAN
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Non-visual arrestin-3
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Homo
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<M><G><E><K><P><G><T><R><V><F><K><K><S><S><P><N><C><K><L><T><V><Y><L><G><K><R><D><F><V><D><H><L><D><K><V><D><P><V><D><G><V><V><L><V><D><P><D><Y><L><K><D><R><K><V><F><V><T><L><T><C><A><F><R><Y><G><R><E><D><L><D><V><L><G><L><S><F><R><K><D><L><F><I><A><T><Y><Q><A><F><P><P><V><P><N><P><P><R><P><P><T><R><L><Q><D><R><L><L><R><K><L><G><Q><H><A><H><P><F><F><F><T><I><P><Q><N><L><P><C><S><V><T><L><Q><P><G><P><E><D><T><G><K><A><C><G><V><D><F><E><I><R><A><F><C><A><K><S><L><E><E><K><S><H><K><R><N><S><V><R><L><V><I><R><K><V><Q><F><A><P><E><K><P><G><P><Q><P><S><A><E><T><T><R><H><F><L><M><S><D><R><S><L><H><L><E><A><S><L><D><K><E><L><Y><Y><H><G><E><P><L><N><V><N><V><H><V><T><N><N><S><T><K><T><V><K><K><I><K><V><S><V><R><Q><Y><A><D><I><C><L><F><S><T><A><Q><Y><K><C><P><V><A><Q><L><E><Q><D><D><Q><V><S><P><S><S><T><F><C><K><V><Y><T><I><T><P><L><L><S><D><N><R><E><K><R><G><L><A><L><D><G><K><L><K><H><E><D><T><N><L><A><S><S><T><I><V><K><E><G><A><N><K><E><V><L><G><I><L><V><S><Y><R><V><K><V><K><L><V><V><S><R><G><G><D><V><S><V><E><L><P><F><V><L><M><H><P><K><P><H><D><H><I><P><L><P><R><P><Q><S><A><A><P><E><T><D><V><P><V><D><T><N><L><I><E><F><D><T><N><Y><A><T><D><D><D><I><V><F><E><D><F><A><R><L><R><L><K><G><M><K><D><D><D><Y><D><D><Q><L><C>
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Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling.
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P32121
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P35575
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G6PC1_HUMAN
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Glucose-6-phosphatase alpha
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Homo
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<M><E><E><G><M><N><V><L><H><D><F><G><I><Q><S><T><H><Y><L><Q><V><N><Y><Q><D><S><Q><D><W><F><I><L><V><S><V><I><A><D><L><R><N><A><F><Y><V><L><F><P><I><W><F><H><L><Q><E><A><V><G><I><K><L><L><W><V><A><V><I><G><D><W><L><N><L><V><F><K><W><I><L><F><G><Q><R><P><Y><W><W><V><L><D><T><D><Y><Y><S><N><T><S><V><P><L><I><K><Q><F><P><V><T><C><E><T><G><P><G><S><P><S><G><H><A><M><G><T><A><G><V><Y><Y><V><M><V><T><S><T><L><S><I><F><Q><G><K><I><K><P><T><Y><R><F><R><C><L><N><V><I><L><W><L><G><F><W><A><V><Q><L><N><V><C><L><S><R><I><Y><L><A><A><H><F><P><H><Q><V><V><A><G><V><L><S><G><I><A><V><A><E><T><F><S><H><I><H><S><I><Y><N><A><S><L><K><K><Y><F><L><I><T><F><F><L><F><S><F><A><I><G><F><Y><L><L><L><K><G><L><G><V><D><L><L><W><T><L><E><K><A><Q><R><W><C><E><Q><P><E><W><V><H><I><D><T><T><P><F><A><S><L><L><K><N><L><G><T><L><F><G><L><G><L><A><L><N><S><S><M><Y><R><E><S><C><K><G><K><L><S><K><W><L><P><F><R><L><S><S><I><V><A><S><L><V><L><L><H><V><F><D><S><L><K><P><P><S><Q><V><E><L><V><F><Y><V><L><S><F><C><K><S><A><V><V><P><L><A><S><V><S><V><I><P><Y><C><L><A><Q><V><L><G><Q><P><H><K><K><S><L>
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Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.<BOP>
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P35575
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Q02643
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GHRHR_HUMAN
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Growth hormone-releasing factor receptor
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Homo
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<M><D><R><R><M><W><G><A><H><V><F><C><V><L><S><P><L><P><T><V><L><G><H><M><H><P><E><C><D><F><I><T><Q><L><R><E><D><E><S><A><C><L><Q><A><A><E><E><M><P><N><T><T><L><G><C><P><A><T><W><D><G><L><L><C><W><P><T><A><G><S><G><E><W><V><T><L><P><C><P><D><F><F><S><H><F><S><S><E><S><G><A><V><K><R><D><C><T><I><T><G><W><S><E><P><F><P><P><Y><P><V><A><C><P><V><P><L><E><L><L><A><E><E><E><S><Y><F><S><T><V><K><I><I><Y><T><V><G><H><S><I><S><I><V><A><L><F><V><A><I><T><I><L><V><A><L><R><R><L><H><C><P><R><N><Y><V><H><T><Q><L><F><T><T><F><I><L><K><A><G><A><V><F><L><K><D><A><A><L><F><H><S><D><D><T><D><H><C><S><F><S><T><V><L><C><K><V><S><V><A><A><S><H><F><A><T><M><T><N><F><S><W><L><L><A><E><A><V><Y><L><N><C><L><L><A><S><T><S><P><S><S><R><R><A><F><W><W><L><V><L><A><G><W><G><L><P><V><L><F><T><G><T><W><V><S><C><K><L><A><F><E><D><I><A><C><W><D><L><D><D><T><S><P><Y><W><W><I><I><K><G><P><I><V><L><S><V><G><V><N><F><G><L><F><L><N><I><I><R><I><L><V><R><K><L><E><P><A><Q><G><S><L><H><T><Q><S><Q><Y><W><R><L><S><K><S><T><L><F><L><I><P><L><F><G><I><H><Y><I><I><F><N><F><L><P><D><N><A><G><L><G><I><R><L><P><L><E><L><G><L><G><S><F><Q><G><F><I><V><A><I><L><Y><C><F><L><N><Q><E><V><R><T><E><I><S><R><K><W><H><G><H><D><P><E><L><L><P><A><W><R><T><R><A><K><W><T><T><P><S><R><S><A><A><K><V><L><T><S><M><C>
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Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.<BOP>
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Q02643
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Q96HE7
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ERO1A_HUMAN
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Oxidoreductin-1-L-alpha
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Homo
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<M><G><R><G><W><G><F><L><F><G><L><L><G><A><V><W><L><L><S><S><G><H><G><E><E><Q><P><P><E><T><A><A><Q><R><C><F><C><Q><V><S><G><Y><L><D><D><C><T><C><D><V><E><T><I><D><R><F><N><N><Y><R><L><F><P><R><L><Q><K><L><L><E><S><D><Y><F><R><Y><Y><K><V><N><L><K><R><P><C><P><F><W><N><D><I><S><Q><C><G><R><R><D><C><A><V><K><P><C><Q><S><D><E><V><P><D><G><I><K><S><A><S><Y><K><Y><S><E><E><A><N><N><L><I><E><E><C><E><Q><A><E><R><L><G><A><V><D><E><S><L><S><E><E><T><Q><K><A><V><L><Q><W><T><K><H><D><D><S><S><D><N><F><C><E><A><D><D><I><Q><S><P><E><A><E><Y><V><D><L><L><L><N><P><E><R><Y><T><G><Y><K><G><P><D><A><W><K><I><W><N><V><I><Y><E><E><N><C><F><K><P><Q><T><I><K><R><P><L><N><P><L><A><S><G><Q><G><T><S><E><E><N><T><F><Y><S><W><L><E><G><L><C><V><E><K><R><A><F><Y><R><L><I><S><G><L><H><A><S><I><N><V><H><L><S><A><R><Y><L><L><Q><E><T><W><L><E><K><K><W><G><H><N><I><T><E><F><Q><Q><R><F><D><G><I><L><T><E><G><E><G><P><R><R><L><K><N><L><Y><F><L><Y><L><I><E><L><R><A><L><S><K><V><L><P><F><F><E><R><P><D><F><Q><L><F><T><G><N><K><I><Q><D><E><E><N><K><M><L><L><L><E><I><L><H><E><I><K><S><F><P><L><H><F><D><E><N><S><F><F><A><G><D><K><K><E><A><H><K><L><K><E><D><F><R><L><H><F><R><N><I><S><R><I><M><D><C><V><G><C><F><K><C><R><L><W><G><K><L><Q><T><Q><G><L><G><T><A><L><K><I><L><F><S><E><K><L><I><A><N><M><P><E><S><G><P><S><Y><E><F><H><L><T><R><Q><E><I><V><S><L><F><N><A><F><G><R><I><S><T><S><V><K><E><L><E><N><F><R><N><L><L><Q><N><I><H>
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Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins . Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin.<BOP>
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Q96HE7
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Q8N300
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SVBP_HUMAN
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Coiled coil domain-containing protein 23
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Homo
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<M><D><P><P><A><R><K><E><K><T><K><V><K><E><S><V><S><R><V><E><K><A><K><Q><K><S><A><Q><Q><E><L><K><Q><R><Q><R><A><E><I><Y><A><L><N><R><V><M><T><E><L><E><Q><Q><Q><F><D><E><F><C><K><Q><M><Q><P><P><G><E>
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Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin . This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning . Also required to enhance the solubility and secretion of VASH1 and VASH2 . Plays a role in axon and excitatory synapse formation .<BOP>
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Q8N300
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P51793
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CLCN4_HUMAN
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Chloride transporter ClC-4
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Homo
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<M><V><N><A><G><A><M><S><G><S><G><N><L><M><D><F><L><D><E><P><F><P><D><V><G><T><Y><E><D><F><H><T><I><D><W><L><R><E><K><S><R><D><T><D><R><H><R><K><I><T><S><K><S><K><E><S><I><W><E><F><I><K><S><L><L><D><A><W><S><G><W><V><V><M><L><L><I><G><L><L><A><G><T><L><A><G><V><I><D><L><A><V><D><W><M><T><D><L><K><E><G><V><C><L><S><A><F><W><Y><S><H><E><Q><C><C><W><T><S><N><E><T><T><F><E><D><R><D><K><C><P><L><W><Q><K><W><S><E><L><L><V><N><Q><S><E><G><A><S><A><Y><I><L><N><Y><L><M><Y><I><L><W><A><L><L><F><A><F><L><A><V><S><L><V><R><V><F><A><P><Y><A><C><G><S><G><I><P><E><I><K><T><I><L><S><G><F><I><I><R><G><Y><L><G><K><W><T><L><L><I><K><T><V><T><L><V><L><V><V><S><S><G><L><S><L><G><K><E><G><P><L><V><H><V><A><C><C><C><G><N><F><F><S><S><L><F><S><K><Y><S><K><N><E><G><K><R><R><E><V><L><S><A><A><A><A><A><G><V><S><V><A><F><G><A><P><I><G><G><V><L><F><S><L><E><E><V><S><Y><Y><F><P><L><K><T><L><W><R><S><F><F><A><A><L><V><A><A><F><T><L><R><S><I><N><P><F><G><N><S><R><L><V><L><F><Y><V><E><Y><H><T><P><W><Y><M><A><E><L><F><P><F><I><L><L><G><V><F><G><G><L><W><G><T><L><F><I><R><C><N><I><A><W><C><R><R><R><K><T><T><R><L><G><K><Y><P><V><L><E><V><I><V><V><T><A><I><T><A><I><I><A><Y><P><N><P><Y><T><R><Q><S><T><S><E><L><I><S><E><L><F><N><D><C><G><A><L><E><S><S><Q><L><C><D><Y><I><N><D><P><N><M><T><R><P><V><D><D><I><P><D><R><P><A><G><V><G><V><Y><T><A><M><W><Q><L><A><L><A><L><I><F><K><I><V><V><T><I><F><T><F><G><M><K><I><P><S><G><L><F><I><P><S><M><A><V><G><A><I><A><G><R><M><V><G><I><G><V><E><Q><L><A><Y><H><H><H><D><W><I><I><F><R><N><W><C><R><P><G><A><D><C><V><T><P><G><L><Y><A><M><V><G><A><A><A><C><L><G><G><V><T><R><M><T><V><S><L><V><V><I><M><F><E><L><T><G><G><L><E><Y><I><V><P><L><M><A><A><A><V><T><S><K><W><V><A><D><A><F><G><K><E><G><I><Y><E><A><H><I><H><L><N><G><Y><P><F><L><D><V><K><D><E><F><T><H><R><T><L><A><T><D><V><M><R><P><R><R><G><E><P><P><L><S><V><L><T><Q><D><S><M><T><V><E><D><V><E><T><L><I><K><E><T><D><Y><N><G><F><P><V><V><V><S><R><D><S><E><R><L><I><G><F><A><Q><R><R><E><L><I><L><A><I><K><N><A><R><Q><R><Q><E><G><I><V><S><N><S><I><M><Y><F><T><E><E><P><P><E><L><P><A><N><S><P><H><P><L><K><L><R><R><I><L><N><L><S><P><F><T><V><T><D><H><T><P><M><E><T><V><V><D><I><F><R><K><L><G><L><R><Q><C><L><V><T><R><S><G><R><L><L><G><I><I><T><K><K><D><V><L><R><H><M><A><Q><M><A><N><Q><D><P><E><S><I><M><F><N>
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Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons . The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons . The presence of conserved gating glutamate residues is typical for family members that function as antiporters .<BOP>
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P51793
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Q9NYW3
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TA2R7_HUMAN
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Taste receptor family B member 4
|
Homo
|
<M><A><D><K><V><Q><T><T><L><L><F><L><A><V><G><E><F><S><V><G><I><L><G><N><A><F><I><G><L><V><N><C><M><D><W><V><K><K><R><K><I><A><S><I><D><L><I><L><T><S><L><A><I><S><R><I><C><L><L><C><V><I><L><L><D><C><F><I><L><V><L><Y><P><D><V><Y><A><T><G><K><E><M><R><I><I><D><F><F><W><T><L><T><N><H><L><S><I><W><F><A><T><C><L><S><I><Y><Y><F><F><K><I><G><N><F><F><H><P><L><F><L><W><M><K><W><R><I><D><R><V><I><S><W><I><L><L><G><C><V><V><L><S><V><F><I><S><L><P><A><T><E><N><L><N><A><D><F><R><F><C><V><K><A><K><R><K><T><N><L><T><W><S><C><R><V><N><K><T><Q><H><A><S><T><K><L><F><L><N><L><A><T><L><L><P><F><C><V><C><L><M><S><F><F><L><L><I><L><S><L><R><R><H><I><R><R><M><Q><L><S><A><T><G><C><R><D><P><S><T><E><A><H><V><R><A><L><K><A><V><I><S><F><L><L><L><F><I><A><Y><Y><L><S><F><L><I><A><T><S><S><Y><F><M><P><E><T><E><L><A><V><I><F><G><E><S><I><A><L><I><Y><P><S><S><H><S><F><I><L><I><L><G><N><N><K><L><R><H><A><S><L><K><V><I><W><K><V><M><S><I><L><K><G><R><K><F><Q><Q><H><K><Q><I>
|
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.<BOP>
|
Q9NYW3
|
Q99547
|
MPH6_HUMAN
|
M-phase phosphoprotein 6
|
Homo
|
<M><A><A><E><R><K><T><R><L><S><K><N><L><L><R><M><K><F><M><Q><R><G><L><D><S><E><T><K><K><Q><L><E><E><E><E><K><K><I><I><S><E><E><H><W><Y><L><D><L><P><E><L><K><E><K><E><S><F><I><I><E><E><Q><S><F><L><L><C><E><D><L><L><Y><G><R><M><S><F><R><G><F><N><P><E><V><E><K><L><M><L><Q><M><N><A><K><H><K><A><E><E><V><E><D><E><T><V><E><L><D><V><S><D><E><E><M><A><R><R><Y><E><T><L><V><G><T><I><G><K><K><F><A><R><K><R><D><H><A><N><Y><E><E><D><E><N><G><D><I><T><P><I><K><A><K><K><M><F><L><K><P><Q><D>
|
RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.<BOP>
|
Q99547
|
Q96BM0
|
I27L1_HUMAN
|
Interferon-stimulated gene 12c protein
|
Homo
|
<M><G><K><E><S><G><W><D><S><G><R><A><A><V><A><A><V><V><G><G><V><V><A><V><G><T><V><L><V><A><L><S><A><M><G><F><T><S><V><G><I><A><A><S><S><I><A><A><K><M><M><S><T><A><A><I><A><N><G><G><G><V><A><A><G><S><L><V><A><I><L><Q><S><V><G><A><A><G><L><S><V><T><S><K><V><I><G><G><F><A><G><T><A><L><G><A><W><L><G><S><P><P><S><S>
|
Plays a role in the apoptotic process and has a pro-apoptotic activity.<BOP>
|
Q96BM0
|
P01709
|
LV208_HUMAN
|
Ig lambda chain V-II region MGC
|
Homo
|
<M><A><W><A><L><L><L><L><T><L><L><T><Q><G><T><G><S><W><A><Q><S><A><L><T><Q><P><P><S><A><S><G><S><P><G><Q><S><V><T><I><S><C><T><G><T><S><S><D><V><G><G><Y><N><Y><V><S><W><Y><Q><Q><H><P><G><K><A><P><K><L><M><I><Y><E><V><S><K><R><P><S><G><V><P><D><R><F><S><G><S><K><S><G><N><T><A><S><L><T><V><S><G><L><Q><A><E><D><E><A><D><Y><Y><C><S><S><Y><A><G><S><N><N><F>
|
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
|
P01709
|
Q8IU89
|
CERS3_HUMAN
|
Very-long-chain ceramide synthase CERS3
|
Homo
|
<M><F><W><T><F><K><E><W><F><W><L><E><R><F><W><L><P><P><T><I><K><W><S><D><L><E><D><H><D><G><L><V><F><V><K><P><S><H><L><Y><V><T><I><P><Y><A><F><L><L><L><I><I><R><R><V><F><E><K><F><V><A><S><P><L><A><K><S><F><G><I><K><E><T><V><R><K><V><T><P><N><T><V><L><E><N><F><F><K><H><S><T><R><Q><P><L><Q><T><D><I><Y><G><L><A><K><K><C><N><L><T><E><R><Q><V><E><R><W><F><R><S><R><R><N><Q><E><R><P><S><R><L><K><K><F><Q><E><A><C><W><R><F><A><F><Y><L><M><I><T><V><A><G><I><A><F><L><Y><D><K><P><W><L><Y><D><L><W><E><V><W><N><G><Y><P><K><Q><P><L><L><P><S><Q><Y><W><Y><Y><I><L><E><M><S><F><Y><W><S><L><L><F><R><L><G><F><D><V><K><R><K><D><F><L><A><H><I><I><H><H><L><A><A><I><S><L><M><S><F><S><W><C><A><N><Y><I><R><S><G><T><L><V><M><I><V><H><D><V><A><D><I><W><L><E><S><A><K><M><F><S><Y><A><G><W><T><Q><T><C><N><T><L><F><F><I><F><S><T><I><F><F><I><S><R><L><I><V><F><P><F><W><I><L><Y><C><T><L><I><L><P><M><Y><H><L><E><P><F><F><S><Y><I><F><L><N><L><Q><L><M><I><L><Q><V><L><H><L><Y><W><G><Y><Y><I><L><K><M><L><N><R><C><I><F><M><K><S><I><Q><D><V><R><S><D><D><E><D><Y><E><E><E><E><E><E><E><E><E><E><A><T><K><G><K><E><M><D><C><L><K><N><G><L><R><A><E><R><H><L><I><P><N><G><Q><H><G><H>
|
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) . N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively . It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation .<BOP>
|
Q8IU89
|
Q9Y366
|
IFT52_HUMAN
|
Protein NGD5 homolog
|
Homo
|
<M><E><K><E><L><R><S><T><I><L><F><N><A><Y><K><K><E><I><F><T><T><N><N><G><Y><K><S><M><Q><K><K><L><R><S><N><W><K><I><Q><S><L><K><D><E><I><T><S><E><K><L><N><G><V><K><L><W><I><T><A><G><P><R><E><K><F><T><A><A><E><F><E><I><L><K><K><Y><L><D><T><G><G><D><V><F><V><M><L><G><E><G><G><E><S><R><F><D><T><N><I><N><F><L><L><E><E><Y><G><I><M><V><N><N><D><A><V><V><R><N><V><Y><H><K><Y><F><H><P><K><E><A><L><V><S><S><G><V><L><N><R><E><I><S><R><A><A><G><K><A><V><P><G><I><I><D><E><E><S><S><G><N><N><A><Q><A><L><T><F><V><Y><P><F><G><A><T><L><S><V><M><K><P><A><V><A><V><L><S><T><G><S><V><C><F><P><L><N><R><P><I><L><A><F><Y><H><S><K><N><Q><G><G><K><L><A><V><L><G><S><C><H><M><F><S><D><Q><Y><L><D><K><E><E><N><S><K><I><M><D><V><V><F><Q><W><L><T><T><G><D><I><H><L><N><Q><I><D><A><E><D><P><E><I><S><D><Y><M><M><L><P><Y><T><A><T><L><S><K><R><N><R><E><C><L><Q><E><S><D><E><I><P><R><D><F><T><T><L><F><D><L><S><I><F><Q><L><D><T><T><S><F><H><S><V><I><E><A><H><E><Q><L><N><V><K><H><E><P><L><Q><L><I><Q><P><Q><F><E><T><P><L><P><T><L><Q><P><A><V><F><P><P><S><F><R><E><L><P><P><P><P><L><E><L><F><D><L><D><E><T><F><S><S><E><K><A><R><L><A><Q><I><T><N><K><C><T><E><E><D><L><E><F><Y><V><R><K><C><G><D><I><L><G><V><T><S><K><L><P><K><D><Q><Q><D><A><K><H><I><L><E><H><V><F><F><Q><V><V><E><F><K><K><L><N><Q><E><H><D><I><D><T><S><E><T><A><F><Q><N><N><F>
|
Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia . Required for the anterograde transport of IFT88 .<BOP>
|
Q9Y366
|
P51665
|
PSMD7_HUMAN
|
Proteasome subunit p40
|
Homo
|
<M><P><E><L><A><V><Q><K><V><V><V><H><P><L><V><L><L><S><V><V><D><H><F><N><R><I><G><K><V><G><N><Q><K><R><V><V><G><V><L><L><G><S><W><Q><K><K><V><L><D><V><S><N><S><F><A><V><P><F><D><E><D><D><K><D><D><S><V><W><F><L><D><H><D><Y><L><E><N><M><Y><G><M><F><K><K><V><N><A><R><E><R><I><V><G><W><Y><H><T><G><P><K><L><H><K><N><D><I><A><I><N><E><L><M><K><R><Y><C><P><N><S><V><L><V><I><I><D><V><K><P><K><D><L><G><L><P><T><E><A><Y><I><S><V><E><E><V><H><D><D><G><T><P><T><S><K><T><F><E><H><V><T><S><E><I><G><A><E><E><A><E><E><V><G><V><E><H><L><L><R><D><I><K><D><T><T><V><G><T><L><S><Q><R><I><T><N><Q><V><H><G><L><K><G><L><N><S><K><L><L><D><I><R><S><Y><L><E><K><V><A><T><G><K><L><P><I><N><H><Q><I><I><Y><Q><L><Q><D><V><F><N><L><L><P><D><V><S><L><Q><E><F><V><K><A><F><Y><L><K><T><N><D><Q><M><V><V><V><Y><L><A><S><L><I><R><S><V><V><A><L><H><N><L><I><N><N><K><I><A><N><R><D><A><E><K><K><E><G><Q><E><K><E><E><S><K><K><D><R><K><E><D><K><E><K><D><K><D><K><E><K><S><D><V><K><K><E><E><K><K><E><K><K>
|
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.<BOP>
|
P51665
|
P57105
|
SYJ2B_HUMAN
|
Mitochondrial outer membrane protein 25
|
Homo
|
<M><N><G><R><V><D><Y><L><V><T><E><E><E><I><N><L><T><R><G><P><S><G><L><G><F><N><I><V><G><G><T><D><Q><Q><Y><V><S><N><D><S><G><I><Y><V><S><R><I><K><E><N><G><A><A><A><L><D><G><R><L><Q><E><G><D><K><I><L><S><V><N><G><Q><D><L><K><N><L><L><H><Q><D><A><V><D><L><F><R><N><A><G><Y><A><V><S><L><R><V><Q><H><R><L><Q><V><Q><N><G><P><I><G><H><R><G><E><G><D><P><S><G><I><P><I><F><M><V><L><V><P><V><F><A><L><T><M><V><A><A><W><A><F><M><R><Y><R><Q><Q><L>
|
Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.<BOP>
|
P57105
|
Q5UAW9
|
GP157_HUMAN
|
G-protein coupled receptor 157
|
Homo
|
<M><Q><P><S><P><P><P><T><E><L><V><P><S><E><R><A><V><V><L><L><S><C><A><L><S><A><L><G><S><G><L><L><V><A><T><H><A><L><W><P><D><L><R><S><R><A><R><R><L><L><L><F><L><S><L><A><D><L><L><S><A><A><S><Y><F><Y><G><V><L><Q><N><F><A><G><P><S><W><D><C><V><L><Q><G><A><L><S><T><F><A><N><T><S><S><F><F><W><T><V><A><I><A><L><Y><L><Y><L><S><I><V><R><A><A><R><G><P><R><T><D><R><L><L><W><A><F><H><V><V><S><W><G><V><P><L><V><I><T><V><A><A><V><A><L><K><K><I><G><Y><D><A><S><D><V><S><V><G><W><C><W><I><D><L><E><A><K><D><H><V><L><W><M><L><L><T><G><K><L><W><E><M><L><A><Y><V><L><L><P><L><L><Y><L><L><V><R><K><H><I><N><R><A><H><T><A><L><S><E><Y><R><P><I><L><S><Q><E><H><R><L><L><R><H><S><S><M><A><D><K><K><L><V><L><I><P><L><I><F><I><G><L><R><V><W><S><T><V><R><F><V><L><T><L><C><G><S><P><A><V><Q><T><P><V><L><V><V><L><H><G><I><G><N><T><F><Q><G><G><A><N><C><I><M><F><V><L><C><T><R><A><V><R><T><R><L><F><S><L><C><C><C><C><C><S><S><Q><P><P><T><K><S><P><A><G><T><P><K><A><P><A><P><S><K><P><G><E><S><Q><E><S><Q><G><T><P><G><E><L><P><S><T>
|
Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.<BOP>
|
Q5UAW9
|
P25713
|
MT3_HUMAN
|
Metallothionein-III
|
Homo
|
<M><D><P><E><T><C><P><C><P><S><G><G><S><C><T><C><A><D><S><C><K><C><E><G><C><K><C><T><S><C><K><K><S><C><C><S><C><C><P><A><E><C><E><K><C><A><K><D><C><V><C><K><G><G><E><A><A><E><A><E><A><E><K><C><S><C><C><Q>
|
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.<BOP>
|
P25713
|
P31641
|
SC6A6_HUMAN
|
Solute carrier family 6 member 6
|
Homo
|
<M><A><T><K><E><K><L><Q><C><L><K><D><F><H><K><D><I><L><K><P><S><P><G><K><S><P><G><T><R><P><E><D><E><A><E><G><K><P><P><Q><R><E><K><W><S><S><K><I><D><F><V><L><S><V><A><G><G><F><V><G><L><G><N><V><W><R><F><P><Y><L><C><Y><K><N><G><G><G><A><F><L><I><P><Y><F><I><F><L><F><G><S><G><L><P><V><F><F><L><E><I><I><I><G><Q><Y><T><S><E><G><G><I><T><C><W><E><K><I><C><P><L><F><S><G><I><G><Y><A><S><V><V><I><V><S><L><L><N><V><Y><Y><I><V><I><L><A><W><A><T><Y><Y><L><F><Q><S><F><Q><K><E><L><P><W><A><H><C><N><H><S><W><N><T><P><H><C><M><E><D><T><M><R><K><N><K><S><V><W><I><T><I><S><S><T><N><F><T><S><P><V><I><E><F><W><E><R><N><V><L><S><L><S><P><G><I><D><H><P><G><S><L><K><W><D><L><A><L><C><L><L><L><V><W><L><V><C><F><F><C><I><W><K><G><V><R><S><T><G><K><V><V><Y><F><T><A><T><F><P><F><A><M><L><L><V><L><L><V><R><G><L><T><L><P><G><A><G><A><G><I><K><F><Y><L><Y><P><D><I><T><R><L><E><D><P><Q><V><W><I><D><A><G><T><Q><I><F><F><S><Y><A><I><C><L><G><A><M><T><S><L><G><S><Y><N><K><Y><K><Y><N><S><Y><R><D><C><M><L><L><G><C><L><N><S><G><T><S><F><V><S><G><F><A><I><F><S><I><L><G><F><M><A><Q><E><Q><G><V><D><I><A><D><V><A><E><S><G><P><G><L><A><F><I><A><Y><P><K><A><V><T><M><M><P><L><P><T><F><W><S><I><L><F><F><I><M><L><L><L><L><G><L><D><S><Q><F><V><E><V><E><G><Q><I><T><S><L><V><D><L><Y><P><S><F><L><R><K><G><Y><R><R><E><I><F><I><A><F><V><C><S><I><S><Y><L><L><G><L><T><M><V><T><E><G><G><M><Y><V><F><Q><L><F><D><Y><Y><A><A><S><G><V><C><L><L><W><V><A><F><F><E><C><F><V><I><A><W><I><Y><G><G><D><N><L><Y><D><G><I><E><D><M><I><G><Y><R><P><G><P><W><M><K><Y><S><W><A><V><I><T><P><V><L><C><V><G><C><F><I><F><S><L><V><K><Y><V><P><L><T><Y><N><K><T><Y><V><Y><P><N><W><A><I><G><L><G><W><S><L><A><L><S><S><M><L><C><V><P><L><V><I><V><I><R><L><C><Q><T><E><G><P><F><L><V><R><V><K><Y><L><L><T><P><R><E><P><N><R><W><A><V><E><R><E><G><A><T><P><Y><N><S><R><T><V><M><N><G><A><L><V><K><P><T><H><I><I><V><E><T><M><M>
|
Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.<BOP>
|
P31641
|
Q9P2X0
|
DPM3_HUMAN
|
Prostin-1
|
Homo
|
<M><T><K><L><A><Q><W><L><W><G><L><A><I><L><G><S><T><W><V><A><L><T><T><G><A><L><G><L><E><L><P><L><S><C><Q><E><V><L><W><P><L><P><A><Y><L><L><V><S><A><G><C><Y><A><L><G><T><V><G><Y><R><V><A><T><F><H><D><C><E><D><A><A><R><E><L><Q><S><Q><I><Q><E><A><R><A><D><L><A><R><R><G><L><R><F>
|
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the endoplasmic reticulum.<BOP>
|
Q9P2X0
|
Q9BYP8
|
KR171_HUMAN
|
Keratin-associated protein 16.1
|
Homo
|
<M><G><C><C><P><G><D><C><F><T><C><C><T><Q><E><Q><N><C><C><E><E><C><C><C><Q><P><G><C><C><G><C><C><G><S><C><C><G><C><G><G><S><G><C><G><G><S><G><C><G><G><S><C><C><G><S><S><C><C><G><S><G><C><G><G><C><G><G><C><G><G><C><G><G><G><C><C><G><S><S><C><C><G><S><S><C><C><G><S><G><C><C><G><P><V><C><C><Q><P><T><P><I><C><D><T><K>
|
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
|
Q9BYP8
|
Q3KRA9
|
ALKB6_HUMAN
|
Alkylated DNA repair protein alkB homolog 6
|
Homo
|
<M><E><E><Q><D><A><R><V><P><A><L><E><P><F><R><V><E><Q><A><P><P><V><I><Y><Y><V><P><D><F><I><S><K><E><E><E><E><Y><L><L><R><Q><V><F><N><A><P><K><P><K><W><T><Q><L><S><G><R><K><L><Q><N><W><G><G><L><P><H><P><R><G><M><V><P><E><R><L><P><P><W><L><Q><R><Y><V><D><K><V><S><N><L><S><L><F><G><G><L><P><A><N><H><V><L><V><N><Q><Y><L><P><G><E><G><I><M><P><H><E><D><G><P><L><Y><Y><P><T><V><S><T><I><S><L><G><S><H><T><V><L><D><F><Y><E><P><R><R><P><E><D><D><D><P><T><E><Q><P><R><P><P><P><R><P><T><T><S><L><L><L><E><P><R><S><L><L><V><L><R><G><P><A><Y><T><R><L><L><H><G><I><A><A><A><R><V><D><A><L><D><A><A><S><S><P><P><N><A><A><A><C><P><S><A><R><P><G><A><C><L><V><R><G><T><R><V><S><L><T><I><R><R><V><P><R><V><L><R><A><G><L><L><L><G><K>
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Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.<BOP>
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Q3KRA9
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Q9Y6E2
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5MP1_HUMAN
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Basic leucine zipper and W2 domain-containing protein 2
|
Homo
|
<M><N><K><H><Q><K><P><V><L><T><G><Q><R><F><K><T><R><K><R><D><E><K><E><K><F><E><P><T><V><F><R><D><T><L><V><Q><G><L><N><E><A><G><D><D><L><E><A><V><A><K><F><L><D><S><T><G><S><R><L><D><Y><R><R><Y><A><D><T><L><F><D><I><L><V><A><G><S><M><L><A><P><G><G><T><R><I><D><D><G><D><K><T><K><M><T><N><H><C><V><F><S><A><N><E><D><H><E><T><I><R><N><Y><A><Q><V><F><N><K><L><I><R><R><Y><K><Y><L><E><K><A><F><E><D><E><M><K><K><L><L><L><F><L><K><A><F><S><E><T><E><Q><T><K><L><A><M><L><S><G><I><L><L><G><N><G><T><L><P><A><T><I><L><T><S><L><F><T><D><S><L><V><K><E><G><I><A><A><S><F><A><V><K><L><F><K><A><W><M><A><E><K><D><A><N><S><V><T><S><S><L><R><K><A><N><L><D><K><R><L><L><E><L><F><P><V><N><R><Q><S><V><D><H><F><A><K><Y><F><T><D><A><G><L><K><E><L><S><D><F><L><R><V><Q><Q><S><L><G><T><R><K><E><L><Q><K><E><L><Q><E><R><L><S><Q><E><C><P><I><K><E><V><V><L><Y><V><K><E><E><M><K><R><N><D><L><P><E><T><A><V><I><G><L><L><W><T><C><I><M><N><A><V><E><W><N><K><K><E><E><L><V><A><E><Q><A><L><K><H><L><K><Q><Y><A><P><L><L><A><V><F><S><S><Q><G><Q><S><E><L><I><L><L><Q><K><V><Q><E><Y><C><Y><D><N><I><H><F><M><K><A><F><Q><K><I><V><V><L><F><Y><K><A><D><V><L><S><E><E><A><I><L><K><W><Y><K><E><A><H><V><A><K><G><K><S><V><F><L><D><Q><M><K><K><F><V><E><W><L><Q><N><A><E><E><E><S><E><S><E><G><E><E><N>
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Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function . Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner .<BOP>
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Q9Y6E2
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Q9NVS9
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PNPO_HUMAN
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Pyridoxamine-phosphate oxidase
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Homo
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<M><T><C><W><L><R><G><V><T><A><T><F><G><R><P><A><E><W><P><G><Y><L><S><H><L><C><G><R><S><A><A><M><D><L><G><P><M><R><K><S><Y><R><G><D><R><E><A><F><E><E><T><H><L><T><S><L><D><P><V><K><Q><F><A><A><W><F><E><E><A><V><Q><C><P><D><I><G><E><A><N><A><M><C><L><A><T><C><T><R><D><G><K><P><S><A><R><M><L><L><L><K><G><F><G><K><D><G><F><R><F><F><T><N><F><E><S><R><K><G><K><E><L><D><S><N><P><F><A><S><L><V><F><Y><W><E><P><L><N><R><Q><V><R><V><E><G><P><V><K><K><L><P><E><E><E><A><E><C><Y><F><H><S><R><P><K><S><S><Q><I><G><A><V><V><S><H><Q><S><S><V><I><P><D><R><E><Y><L><R><K><K><N><E><E><L><E><Q><L><Y><Q><D><Q><E><V><P><K><P><K><S><W><G><G><Y><V><L><Y><P><Q><V><M><E><F><W><Q><G><Q><T><N><R><L><H><D><R><I><V><F><R><R><G><L><P><T><G><D><S><P><L><G><P><M><T><H><R><G><E><E><D><W><L><Y><E><R><L><A><P>
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Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).<BOP>
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Q9NVS9
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O15552
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FFAR2_HUMAN
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G-protein coupled receptor 43
|
Homo
|
<M><L><P><D><W><K><S><S><L><I><L><M><A><Y><I><I><I><F><L><T><G><L><P><A><N><L><L><A><L><R><A><F><V><G><R><I><R><Q><P><Q><P><A><P><V><H><I><L><L><L><S><L><T><L><A><D><L><L><L><L><L><L><L><P><F><K><I><I><E><A><A><S><N><F><R><W><Y><L><P><K><V><V><C><A><L><T><S><F><G><F><Y><S><S><I><Y><C><S><T><W><L><L><A><G><I><S><I><E><R><Y><L><G><V><A><F><P><V><Q><Y><K><L><S><R><R><P><L><Y><G><V><I><A><A><L><V><A><W><V><M><S><F><G><H><C><T><I><V><I><I><V><Q><Y><L><N><T><T><E><Q><V><R><S><G><N><E><I><T><C><Y><E><N><F><T><D><N><Q><L><D><V><V><L><P><V><R><L><E><L><C><L><V><L><F><F><I><P><M><A><V><T><I><F><C><Y><W><R><F><V><W><I><M><L><S><Q><P><L><V><G><A><Q><R><R><R><R><A><V><G><L><A><V><V><T><L><L><N><F><L><V><C><F><G><P><Y><N><V><S><H><L><V><G><Y><H><Q><R><K><S><P><W><W><R><S><I><A><V><V><F><S><S><L><N><A><S><L><D><P><L><L><F><Y><F><S><S><S><V><V><R><R><A><F><G><R><G><L><Q><V><L><R><N><Q><G><S><S><L><L><G><R><R><G><K><D><T><A><E><G><T><N><E><D><R><G><V><G><Q><G><E><G><M><P><S><S><D><F><T><T><E>
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G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family . Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate
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O15552
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Q99969
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RARR2_HUMAN
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Tazarotene-induced gene 2 protein
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Homo
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<M><R><R><L><L><I><P><L><A><L><W><L><G><A><V><G><V><G><V><A><E><L><T><E><A><Q><R><R><G><L><Q><V><A><L><E><E><F><H><K><H><P><P><V><Q><W><A><F><Q><E><T><S><V><E><S><A><V><D><T><P><F><P><A><G><I><F><V><R><L><E><F><K><L><Q><Q><T><S><C><R><K><R><D><W><K><K><P><E><C><K><V><R><P><N><G><R><K><R><K><C><L><A><C><I><K><L><G><S><E><D><K><V><L><G><R><L><V><H><C><P><I><E><T><Q><V><L><R><E><A><E><E><H><Q><E><T><Q><C><L><R><V><Q><R><A><G><E><D><P><H><S><F><Y><F><P><G><Q><F><A><F><S><K><A><L><P><R><S>
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Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Acts also as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2 . Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and
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Q99969
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A6NI72
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NCF1B_HUMAN
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Putative SH3 and PX domain-containing protein 1B
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Homo
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<M><G><D><T><F><I><R><H><I><A><L><L><G><F><E><K><R><F><V><P><S><Q><H><Y><V><R><Y><M><F><L><V><K><W><Q><D><L><S><E><K><V><V><Y><R><R><F><T><E><I><Y><E><F><H><K><T><L><K><E><M><F><P><I><E><A><G><A><I><N><P><E><N><R><I><I><P><H><L><P><A><P><K><W><F><D><G><Q><R><A><A><E><N><H><Q><G><T><L><T><E><Y><C><G><T><L><M><S><L><P><T><K><I><S><R><C><P><H><L><L><D><F><F><K><V><R><P><D><D><L><K><L><P><T><D><N><Q><T><K><K><P><E><T><Y><L><M><P><K><D><G><K><S><T><A><T><D><I><T><G><P><I><I><L><Q><T><Y><R><A><I><A><N><Y><E><K><T><S><G><S><E><M><A><L><S><T><G><D><V><V><E><V><V><E><K><S><E><S><G><W><W><F><C><Q><M><K><A><K><R><G><W><I><P><A><S><F><L><E><P><L><D><S><P><D><E><T><E><D><P><E><P><N><Y><A><G><E><P><Y><V><A><I><K><A><Y><T><A><V><E><G><D><E><V><S><L><L><E><G><E><A><V><E><V><I><H><K><L><L><D><G><W><W><V><I><R><K><D><D><V><T><G><Y><F><P><S><M><Y><L><Q><K><S><G><Q><D><V><S><Q><A><Q><R><Q><I><K><R><G><A><P><P><R><R><S><S><I><R><N><V><H><S><I><H><Q><R><S><R><K><R><L><S><Q><D><A><Y><R><R><N><S><V><R><F><L><Q><Q><R><R><R><Q><A><R><P><G><P><Q><S><P><G><S><P><L><E><E><E><R><Q><T><Q><R><S><K><P><Q><P><A><V><P><P><R><P><S><A><D><L><I><L><N><R><C><S><E><S><T><K><R><K><L><A><S><A><V>
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May be required for activation of the latent NADPH oxidase (necessary for superoxide production).<BOP>
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A6NI72
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P45378
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TNNT3_HUMAN
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Fast skeletal muscle troponin T
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Homo
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<M><S><D><E><E><V><E><Q><V><E><E><Q><Y><E><E><E><E><E><A><Q><E><E><A><A><E><V><H><E><E><V><H><E><P><E><E><V><Q><E><D><T><A><E><E><D><A><E><E><E><K><P><R><P><K><L><T><A><P><K><I><P><E><G><E><K><V><D><F><D><D><I><Q><K><K><R><Q><N><K><D><L><M><E><L><Q><A><L><I><D><S><H><F><E><A><R><K><K><E><E><E><E><L><V><A><L><K><E><R><I><E><K><R><R><A><E><R><A><E><Q><Q><R><I><R><A><E><K><E><R><E><R><Q><N><R><L><A><E><E><K><A><R><R><E><E><E><D><A><K><R><R><A><E><D><D><L><K><K><K><K><A><L><S><S><M><G><A><N><Y><S><S><Y><L><A><K><A><D><Q><K><R><G><K><K><Q><T><A><R><E><M><K><K><K><I><L><A><E><R><R><K><P><L><N><I><D><H><L><G><E><D><K><L><R><D><K><A><K><E><L><W><E><T><L><H><Q><L><E><I><D><K><F><E><F><G><E><K><L><K><R><Q><K><Y><D><I><T><T><L><R><S><R><I><D><Q><A><Q><K><H><S><K><K><A><G><T><P><A><K><G><K><V><G><G><R><W><K>
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Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.<BOP>
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P45378
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Q15661
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TRYB1_HUMAN
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Tryptase alpha-1
|
Homo
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<M><L><N><L><L><L><L><A><L><P><V><L><A><S><R><A><Y><A><A><P><A><P><G><Q><A><L><Q><R><V><G><I><V><G><G><Q><E><A><P><R><S><K><W><P><W><Q><V><S><L><R><V><H><G><P><Y><W><M><H><F><C><G><G><S><L><I><H><P><Q><W><V><L><T><A><A><H><C><V><G><P><D><V><K><D><L><A><A><L><R><V><Q><L><R><E><Q><H><L><Y><Y><Q><D><Q><L><L><P><V><S><R><I><I><V><H><P><Q><F><Y><T><A><Q><I><G><A><D><I><A><L><L><E><L><E><E><P><V><N><V><S><S><H><V><H><T><V><T><L><P><P><A><S><E><T><F><P><P><G><M><P><C><W><V><T><G><W><G><D><V><D><N><D><E><R><L><P><P><P><F><P><L><K><Q><V><K><V><P><I><M><E><N><H><I><C><D><A><K><Y><H><L><G><A><Y><T><G><D><D><V><R><I><V><R><D><D><M><L><C><A><G><N><T><R><R><D><S><C><Q><G><D><S><G><G><P><L><V><C><K><V><N><G><T><W><L><Q><A><G><V><V><S><W><G><E><G><C><A><Q><P><N><R><P><G><I><Y><T><R><V><T><Y><Y><L><D><W><I><H><H><Y><V><P><K><K><P>
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Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates .<BOP>
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Q15661
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Q9NZP0
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OR6C3_HUMAN
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HSA8
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Homo
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<M><N><H><T><M><V><T><E><F><V><L><L><G><L><S><D><D><P><D><L><Q><I><V><I><F><L><F><L><F><I><T><Y><I><L><S><V><T><G><N><L><T><I><I><T><L><T><F><V><D><S><H><L><Q><T><P><M><Y><F><F><L><R><N><F><S><F><L><E><I><S><F><T><T><V><C><I><P><R><F><L><G><A><I><I><T><R><N><K><T><I><S><Y><N><N><C><A><A><Q><L><F><F><F><I><F><M><G><V><T><E><F><Y><I><L><T><A><M><S><Y><D><R><Y><V><A><I><C><K><P><L><H><Y><T><S><I><M><N><R><K><L><C><T><L><L><V><L><C><A><W><L><S><G><F><L><T><I><F><P><P><L><M><L><L><L><Q><L><D><Y><C><A><S><N><V><I><D><H><F><A><C><D><Y><F><P><L><L><Q><L><S><C><S><D><T><W><L><L><E><V><I><G><F><Y><F><A><L><V><T><L><L><F><T><L><A><L><V><I><L><S><Y><M><Y><I><I><R><T><I><L><R><I><P><S><A><S><Q><R><K><K><A><F><S><T><C><S><S><H><M><I><V><I><S><I><S><Y><G><S><C><I><F><M><Y><A><N><P><S><A><K><E><K><A><S><L><T><K><G><I><A><I><L><N><T><S><V><A><P><M><L><N><P><F><I><Y><T><L><R><N><Q><Q><V><K><Q><A><F><K><N><V><V><H><K><V><V><F><Y><A><N><Q>
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Odorant receptor.<BOP>
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Q9NZP0
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P07306
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ASGR1_HUMAN
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Hepatic lectin H1
|
Homo
|
<M><T><K><E><Y><Q><D><L><Q><H><L><D><N><E><E><S><D><H><H><Q><L><R><K><G><P><P><P><P><Q><P><L><L><Q><R><L><C><S><G><P><R><L><L><L><L><S><L><G><L><S><L><L><L><L><V><V><V><C><V><I><G><S><Q><N><S><Q><L><Q><E><E><L><R><G><L><R><E><T><F><S><N><F><T><A><S><T><E><A><Q><V><K><G><L><S><T><Q><G><G><N><V><G><R><K><M><K><S><L><E><S><Q><L><E><K><Q><Q><K><D><L><S><E><D><H><S><S><L><L><L><H><V><K><Q><F><V><S><D><L><R><S><L><S><C><Q><M><A><A><L><Q><G><N><G><S><E><R><T><C><C><P><V><N><W><V><E><H><E><R><S><C><Y><W><F><S><R><S><G><K><A><W><A><D><A><D><N><Y><C><R><L><E><D><A><H><L><V><V><V><T><S><W><E><E><Q><K><F><V><Q><H><H><I><G><P><V><N><T><W><M><G><L><H><D><Q><N><G><P><W><K><W><V><D><G><T><D><Y><E><T><G><F><K><N><W><R><P><E><Q><P><D><D><W><Y><G><H><G><L><G><G><G><E><D><C><A><H><F><T><D><D><G><R><W><N><D><D><V><C><Q><R><P><Y><R><W><V><C><E><T><E><L><D><K><A><S><Q><E><P><P><L><L>
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Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.<BOP>
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P07306
|
O60512
|
B4GT3_HUMAN
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UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
|
Homo
|
<M><L><R><R><L><L><E><R><P><C><T><L><A><L><L><V><G><S><Q><L><A><V><M><M><Y><L><S><L><G><G><F><R><S><L><S><A><L><F><G><R><D><Q><G><P><T><F><D><Y><S><H><P><R><D><V><Y><S><N><L><S><H><L><P><G><A><P><G><G><P><P><A><P><Q><G><L><P><Y><C><P><E><R><S><P><L><L><V><G><P><V><S><V><S><F><S><P><V><P><S><L><A><E><I><V><E><R><N><P><R><V><E><P><G><G><R><Y><R><P><A><G><C><E><P><R><S><R><T><A><I><I><V><P><H><R><A><R><E><H><H><L><R><L><L><L><Y><H><L><H><P><F><L><Q><R><Q><Q><L><A><Y><G><I><Y><V><I><H><Q><A><G><N><G><T><F><N><R><A><K><L><L><N><V><G><V><R><E><A><L><R><D><E><E><W><D><C><L><F><L><H><D><V><D><L><L><P><E><N><D><H><N><L><Y><V><C><D><P><R><G><P><R><H><V><A><V><A><M><N><K><F><G><Y><S><L><P><Y><P><Q><Y><F><G><G><V><S><A><L><T><P><D><Q><Y><L><K><M><N><G><F><P><N><E><Y><W><G><W><G><G><E><D><D><D><I><A><T><R><V><R><L><A><G><M><K><I><S><R><P><P><T><S><V><G><H><Y><K><M><V><K><H><R><G><D><K><G><N><E><E><N><P><H><R><F><D><L><L><V><R><T><Q><N><S><W><T><Q><D><G><M><N><S><L><T><Y><Q><L><L><A><R><E><L><G><P><L><Y><T><N><I><T><A><D><I><G><T><D><P><R><G><P><R><A><P><S><G><P><R><Y><P><P><G><S><S><Q><A><F><R><Q><E><M><L><Q><R><R><P><P><A><R><P><G><P><L><S><T><A><N><H><T><A><L><R><G><S><H>
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Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.<BOP>
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O60512
|
P48039
|
MTR1A_HUMAN
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Melatonin receptor type 1A
|
Homo
|
<M><Q><G><N><G><S><A><L><P><N><A><S><Q><P><V><L><R><G><D><G><A><R><P><S><W><L><A><S><A><L><A><C><V><L><I><F><T><I><V><V><D><I><L><G><N><L><L><V><I><L><S><V><Y><R><N><K><K><L><R><N><A><G><N><I><F><V><V><S><L><A><V><A><D><L><V><V><A><I><Y><P><Y><P><L><V><L><M><S><I><F><N><N><G><W><N><L><G><Y><L><H><C><Q><V><S><G><F><L><M><G><L><S><V><I><G><S><I><F><N><I><T><G><I><A><I><N><R><Y><C><Y><I><C><H><S><L><K><Y><D><K><L><Y><S><S><K><N><S><L><C><Y><V><L><L><I><W><L><L><T><L><A><A><V><L><P><N><L><R><A><G><T><L><Q><Y><D><P><R><I><Y><S><C><T><F><A><Q><S><V><S><S><A><Y><T><I><A><V><V><V><F><H><F><L><V><P><M><I><I><V><I><F><C><Y><L><R><I><W><I><L><V><L><Q><V><R><Q><R><V><K><P><D><R><K><P><K><L><K><P><Q><D><F><R><N><F><V><T><M><F><V><V><F><V><L><F><A><I><C><W><A><P><L><N><F><I><G><L><A><V><A><S><D><P><A><S><M><V><P><R><I><P><E><W><L><F><V><A><S><Y><Y><M><A><Y><F><N><S><C><L><N><A><I><I><Y><G><L><L><N><Q><N><F><R><K><E><Y><R><R><I><I><V><S><L><C><T><A><R><V><F><F><V><D><S><S><N><D><V><A><D><R><V><K><W><K><P><S><P><L><M><T><N><N><N><V><V><K><V><D><S><V>
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High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.<BOP>
|
P48039
|
Q8N264
|
RHG24_HUMAN
|
p73RhoGAP
|
Homo
|
<M><E><E><N><N><D><S><T><E><N><P><Q><Q><G><Q><G><R><Q><N><A><I><K><C><G><W><L><R><K><Q><G><G><F><V><K><T><W><H><T><R><W><F><V><L><K><G><D><Q><L><Y><Y><F><K><D><E><D><E><T><K><P><L><G><T><I><F><L><P><G><N><K><V><S><E><H><P><C><N><E><E><N><P><G><K><F><L><F><E><V><V><P><G><G><D><R><D><R><M><T><A><N><H><E><S><Y><L><L><M><A><S><T><Q><N><D><M><E><D><W><V><K><S><I><R><R><V><I><W><G><P><F><G><G><G><I><F><G><Q><K><L><E><D><T><V><R><Y><E><K><R><Y><G><N><R><L><A><P><M><L><V><E><Q><C><V><D><F><I><R><Q><R><G><L><K><E><E><G><L><F><R><L><P><G><Q><A><N><L><V><K><E><L><Q><D><A><F><D><C><G><E><K><P><S><F><D><S><N><T><D><V><H><T><V><A><S><L><L><K><L><Y><L><R><E><L><P><E><P><V><I><P><Y><A><K><Y><E><D><F><L><S><C><A><K><L><L><S><K><E><E><E><A><G><V><K><E><L><A><K><Q><V><K><S><L><P><V><V><N><Y><N><L><L><K><Y><I><C><R><F><L><D><E><V><Q><S><Y><S><G><V><N><K><M><S><V><Q><N><L><A><T><V><F><G><P><N><I><L><R><P><K><V><E><D><P><L><T><I><M><E><G><T><V><V><V><Q><Q><L><M><S><V><M><I><S><K><H><D><C><L><F><P><K><D><A><E><L><Q><S><K><P><Q><D><G><V><S><N><N><N><E><I><Q><K><K><A><T><M><G><Q><L><Q><N><K><E><N><N><N><T><K><D><S><P><S><R><Q><C><S><W><D><K><S><E><S><P><Q><R><S><S><M><N><N><G><S><P><T><A><L><S><G><S><K><T><N><S><P><K><N><S><V><H><K><L><D><V><S><R><S><P><P><L><M><V><K><K><N><P><A><F><N><K><G><S><G><I><V><T><N><G><S><F><S><S><S><N><A><E><G><L><E><K><T><Q><T><T><P><N><G><S><L><Q><A><R><R><S><S><S><L><K><V><S><G><T><K><M><G><T><H><S><V><Q><N><G><T><V><R><M><G><I><L><N><S><D><T><L><G><N><P><T><N><V><R><N><M><S><W><L><P><N><G><Y><V><T><L><R><D><N><K><Q><K><E><Q><A><G><E><L><G><Q><H><N><R><L><S><T><Y><D><N><V><H><Q><Q><F><S><M><M><N><L><D><D><K><Q><S><I><D><S><A><T><W><S><T><S><S><C><E><I><S><L><P><E><N><S><N><S><C><R><S><S><T><T><T><C><P><E><Q><D><F><F><G><G><N><F><E><D><P><V><L><D><G><P><P><Q><D><D><L><S><H><P><R><D><Y><E><S><K><S><D><H><R><S><V><G><G><R><S><S><R><A><T><S><S><S><D><N><S><E><T><F><V><G><N><S><S><S><N><H><S><A><L><H><S><L><V><S><S><L><K><Q><E><M><T><K><Q><K><I><E><Y><E><S><R><I><K><S><L><E><Q><R><N><L><T><L><E><T><E><M><M><S><L><H><D><E><L><D><Q><E><R><K><K><F><T><M><I><E><I><K><M><R><N><A><E><R><A><K><E><D><A><E><K><R><N><D><M><L><Q><K><E><M><E><Q><F><F><S><T><F><G><E><L><T><V><E><P><R><R><T><E><R><G><N><T><I><W><I><Q>
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Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.<BOP>
|
Q8N264
|
P10620
|
MGST1_HUMAN
|
Microsomal GST-I
|
Homo
|
<M><V><D><L><T><Q><V><M><D><D><E><V><F><M><A><F><A><S><Y><A><T><I><I><L><S><K><M><M><L><M><S><T><A><T><A><F><Y><R><L><T><R><K><V><F><A><N><P><E><D><C><V><A><F><G><K><G><E><N><A><K><K><Y><L><R><T><D><D><R><V><E><R><V><R><R><A><H><L><N><D><L><E><N><I><I><P><F><L><G><I><G><L><L><Y><S><L><S><G><P><D><P><S><T><A><I><L><H><F><R><L><F><V><G><A><R><I><Y><H><T><I><A><Y><L><T><P><L><P><Q><P><N><R><A><L><S><F><F><V><G><Y><G><V><T><L><S><M><A><Y><R><L><L><K><S><K><L><Y><L>
|
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.<BOP>
|
P10620
|
A0A087WT02
|
TVA92_HUMAN
|
T cell receptor alpha variable 9-2
|
Homo
|
<M><N><Y><S><P><G><L><V><S><L><I><L><L><L><L><G><R><T><R><G><D><S><V><T><Q><M><E><G><P><V><T><L><S><E><E><A><F><L><T><I><N><C><T><Y><T><A><T><G><Y><P><S><L><F><W><Y><V><Q><Y><P><G><E><G><L><Q><L><L><L><K><A><T><K><A><D><D><K><G><S><N><K><G><F><E><A><T><Y><R><K><E><T><T><S><F><H><L><E><K><G><S><V><Q><V><S><D><S><A><V><Y><F><C><A><L><S>
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V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
|
A0A087WT02
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Q86SQ6
|
AGRA1_HUMAN
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G-protein coupled receptor 123
|
Homo
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<M><D><L><K><T><V><L><S><L><P><R><Y><P><G><E><F><L><H><P><V><V><Y><A><C><T><A><V><M><L><L><C><L><L><A><S><F><V><T><Y><I><V><H><Q><S><A><I><R><I><S><R><K><G><R><H><T><L><L><N><F><C><F><H><A><A><L><T><F><T><V><F><A><G><G><I><N><R><T><K><Y><P><I><L><C><Q><A><V><G><I><V><L><H><Y><S><T><L><S><T><M><L><W><I><G><V><T><A><R><N><I><Y><K><Q><V><T><K><K><A><P><L><C><L><D><T><D><Q><P><P><Y><P><R><Q><P><L><L><R><F><Y><L><V><S><G><G><V><P><F><I><I><C><G><V><T><A><A><T><N><I><R><N><Y><G><T><E><D><E><D><T><A><Y><C><W><M><A><W><E><P><S><L><G><A><F><Y><G><P><A><A><I><I><T><L><V><T><C><V><Y><F><L><G><T><Y><V><Q><L><R><R><H><P><G><R><R><Y><E><L><R><T><Q><P><E><E><Q><R><R><L><A><T><P><E><G><G><R><G><I><R><P><G><T><P><P><A><H><D><A><P><G><A><S><V><L><Q><N><E><H><S><F><Q><A><Q><L><R><A><A><A><F><T><L><F><L><F><T><A><T><W><A><F><G><A><L><A><V><S><Q><G><H><F><L><D><M><V><F><S><C><L><Y><G><A><F><C><V><T><L><G><L><F><V><L><I><H><H><C><A><K><R><E><D><V><W><Q><C><W><W><A><C><C><P><P><R><K><D><A><H><P><A><L><D><A><N><G><A><A><L><G><R><A><A><C><L><H><S><P><G><L><G><Q><P><R><G><F><A><H><P><P><G><P><C><K><M><T><N><L><Q><A><A><Q><G><H><A><S><C><L><S><P><A><T><P><C><C><A><K><M><H><C><E><P><L><T><A><D><E><A><H><V><H><L><Q><E><E><G><A><F><G><H><D><P><H><L><H><G><C><L><Q><G><R><T><K><P><P><Y><F><S><R><H><P><A><E><E><P><E><Y><A><Y><H><I><P><S><S><L><D><G><S><P><R><S><S><R><T><D><S><P><P><S><S><L><D><G><P><A><G><T><H><T><L><A><C><C><T><Q><G><D><P><F><P><M><V><T><Q><P><E><G><S><D><G><S><P><A><L><Y><S><C><P><T><Q><P><G><R><E><A><A><L><G><P><G><H><L><E><M><L><R><R><T><Q><S><L><P><F><G><G><P><S><Q><N><G><L><P><K><G><K><L><L><E><G><L><P><F><G><T><D><G><T><G><N><I><R><T><G><P><W><K><N><E><T><T><V>
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Orphan receptor.<BOP>
|
Q86SQ6
|
Q9HA65
|
TBC17_HUMAN
|
TBC1 domain family member 17
|
Homo
|
<M><E><G><A><G><Y><R><V><V><F><E><K><G><G><V><Y><L><H><T><S><A><K><K><Y><Q><D><R><D><S><L><I><A><G><V><I><R><V><V><E><K><D><N><D><V><L><L><H><W><A><P><V><E><E><A><G><D><S><T><Q><I><L><F><S><K><K><D><S><S><G><G><D><S><C><A><S><E><E><E><P><T><F><D><P><G><Y><E><P><D><W><A><V><I><S><T><V><R><P><Q><L><C><H><S><E><P><T><R><G><A><E><P><S><C><P><Q><G><S><W><A><F><S><V><S><L><G><E><L><K><S><I><R><R><S><K><P><G><L><S><W><A><Y><L><V><L><V><T><Q><A><G><G><S><L><P><A><L><H><F><H><R><G><G><T><R><A><L><L><R><V><L><S><R><Y><L><L><L><A><S><S><P><Q><D><S><R><L><Y><L><V><F><P><H><D><S><S><A><L><S><N><S><F><H><H><L><Q><L><F><D><Q><D><S><S><N><V><V><S><R><F><L><Q><D><P><Y><S><T><T><F><S><S><F><S><R><V><T><N><F><F><R><G><A><L><Q><P><Q><P><E><G><A><A><S><D><L><P><P><P><P><D><D><E><P><E><P><G><F><E><V><I><S><C><V><E><L><G><P><R><P><T><V><E><R><G><P><P><V><T><E><E><E><W><A><R><H><V><G><P><E><G><R><L><Q><Q><V><P><E><L><K><N><R><I><F><S><G><G><L><S><P><S><L><R><R><E><A><W><K><F><L><L><G><Y><L><S><W><E><G><T><A><E><E><H><K><A><H><I><R><K><K><T><D><E><Y><F><R><M><K><L><Q><W><K><S><V><S><P><E><Q><E><R><R><N><S><L><L><H><G><Y><R><S><L><I><E><R><D><V><S><R><T><D><R><T><N><K><F><Y><E><G><P><E><N><P><G><L><G><L><L><N><D><I><L><L><T><Y><C><M><Y><H><F><D><L><G><Y><V><Q><G><M><S><D><L><L><S><P><I><L><Y><V><I><Q><N><E><V><D><A><F><W><C><F><C><G><F><M><E><L><V><Q><G><N><F><E><E><S><Q><E><T><M><K><R><Q><L><G><R><L><L><L><L><L><R><V><L><D><P><L><L><C><D><F><L><D><S><Q><D><S><G><S><L><C><F><C><F><R><W><L><L><I><W><F><K><R><E><F><P><F><P><D><V><L><R><L><W><E><V><L><W><T><G><L><P><G><P><N><L><H><L><L><V><A><C><A><I><L><D><M><E><R><D><T><L><M><L><S><G><F><G><S><N><E><I><L><K><H><I><N><E><L><T><M><K><L><S><V><E><D><V><L><T><R><A><E><A><L><H><R><Q><L><T><A><C><P><E><L><P><H><N><V><Q><E><I><L><G><L><A><P><P><A><E><P><H><S><P><S><P><T><A><S><P><L><P><L><S><P><T><R><A><P><P><T><P><P><P><S><T><D><T><A><P><Q><P><D><S><S><L><E><I><L><P><E><E><E><D><E><G><A><D><S>
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Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.<BOP>
|
Q9HA65
|
Q53T59
|
H1BP3_HUMAN
|
HS1-binding protein 3
|
Homo
|
<M><Q><S><P><A><V><L><V><T><S><R><R><L><Q><N><A><H><T><G><L><D><L><T><V><P><Q><H><Q><E><V><R><G><K><M><M><S><G><H><V><E><Y><Q><I><L><V><V><T><R><L><A><A><F><K><S><A><K><H><R><P><E><D><V><V><Q><F><L><V><S><K><K><Y><S><E><I><E><E><F><Y><Q><K><L><S><S><R><Y><A><A><A><S><L><P><P><L><P><R><K><V><L><F><V><G><E><S><D><I><R><E><R><R><A><V><F><N><E><I><L><R><C><V><S><K><D><A><E><L><A><G><S><P><E><L><L><E><F><L><G><T><R><S><P><G><A><A><G><L><T><S><R><D><S><S><V><L><D><G><T><D><S><Q><T><G><N><D><E><E><A><F><D><F><F><E><E><Q><D><Q><V><A><E><E><G><P><P><V><Q><S><L><K><G><E><D><A><E><E><S><L><E><E><E><E><A><L><D><P><L><G><I><M><R><S><K><K><P><K><K><H><P><K><V><A><V><K><A><K><P><S><P><R><L><T><I><F><D><E><E><V><D><P><D><E><G><L><F><G><P><G><R><K><L><S><P><Q><D><P><S><E><D><V><S><S><V><D><P><L><K><L><F><D><D><P><D><L><G><G><A><I><P><L><G><D><S><L><L><L><P><A><A><C><E><S><G><G><P><T><P><S><L><S><H><R><D><A><S><K><E><L><F><R><V><E><E><D><L><D><Q><I><L><N><L><G><A><E><P><K><P><K><P><Q><L><K><P><K><P><P><V><A><A><K><P><V><I><P><R><K><P><A><V><P><P><K><A><G><P><A><E><A><V><A><G><Q><Q><K><P><Q><E><Q><I><Q><A><M><D><E><M><D><I><L><Q><Y><I><Q><D><H><D><T><P><A><Q><A><A><P><S><L><F>
|
May be a modulator of IL-2 signaling.<BOP>
|
Q53T59
|
Q5VWK5
|
IL23R_HUMAN
|
Interleukin-23 receptor
|
Homo
|
<M><N><Q><V><T><I><Q><W><D><A><V><I><A><L><Y><I><L><F><S><W><C><H><G><G><I><T><N><I><N><C><S><G><H><I><W><V><E><P><A><T><I><F><K><M><G><M><N><I><S><I><Y><C><Q><A><A><I><K><N><C><Q><P><R><K><L><H><F><Y><K><N><G><I><K><E><R><F><Q><I><T><R><I><N><K><T><T><A><R><L><W><Y><K><N><F><L><E><P><H><A><S><M><Y><C><T><A><E><C><P><K><H><F><Q><E><T><L><I><C><G><K><D><I><S><S><G><Y><P><P><D><I><P><D><E><V><T><C><V><I><Y><E><Y><S><G><N><M><T><C><T><W><N><A><G><K><L><T><Y><I><D><T><K><Y><V><V><H><V><K><S><L><E><T><E><E><E><Q><Q><Y><L><T><S><S><Y><I><N><I><S><T><D><S><L><Q><G><G><K><K><Y><L><V><W><V><Q><A><A><N><A><L><G><M><E><E><S><K><Q><L><Q><I><H><L><D><D><I><V><I><P><S><A><A><V><I><S><R><A><E><T><I><N><A><T><V><P><K><T><I><I><Y><W><D><S><Q><T><T><I><E><K><V><S><C><E><M><R><Y><K><A><T><T><N><Q><T><W><N><V><K><E><F><D><T><N><F><T><Y><V><Q><Q><S><E><F><Y><L><E><P><N><I><K><Y><V><F><Q><V><R><C><Q><E><T><G><K><R><Y><W><Q><P><W><S><S><L><F><F><H><K><T><P><E><T><V><P><Q><V><T><S><K><A><F><Q><H><D><T><W><N><S><G><L><T><V><A><S><I><S><T><G><H><L><T><S><D><N><R><G><D><I><G><L><L><L><G><M><I><V><F><A><V><M><L><S><I><L><S><L><I><G><I><F><N><R><S><F><R><T><G><I><K><R><R><I><L><L><L><I><P><K><W><L><Y><E><D><I><P><N><M><K><N><S><N><V><V><K><M><L><Q><E><N><S><E><L><M><N><N><N><S><S><E><Q><V><L><Y><V><D><P><M><I><T><E><I><K><E><I><F><I><P><E><H><K><P><T><D><Y><K><K><E><N><T><G><P><L><E><T><R><D><Y><P><Q><N><S><L><F><D><N><T><T><V><V><Y><I><P><D><L><N><T><G><Y><K><P><Q><I><S><N><F><L><P><E><G><S><H><L><S><N><N><N><E><I><T><S><L><T><L><K><P><P><V><D><S><L><D><S><G><N><N><P><R><L><Q><K><H><P><N><F><A><F><S><V><S><S><V><N><S><L><S><N><T><I><F><L><G><E><L><S><L><I><L><N><Q><G><E><C><S><S><P><D><I><Q><N><S><V><E><E><E><T><T><M><L><L><E><N><D><S><P><S><E><T><I><P><E><Q><T><L><L><P><D><E><F><V><S><C><L><G><I><V><N><E><E><L><P><S><I><N><T><Y><F><P><Q><N><I><L><E><S><H><F><N><R><I><S><L><L><E><K>
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Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.<BOP>
|
Q5VWK5
|
Q96JJ7
|
TMX3_HUMAN
|
Thioredoxin-related transmembrane protein 3
|
Homo
|
<M><A><A><W><K><S><W><T><A><L><R><L><C><A><T><V><V><V><L><D><M><V><V><C><K><G><F><V><E><D><L><D><E><S><F><K><E><N><R><N><D><D><I><W><L><V><D><F><Y><A><P><W><C><G><H><C><K><K><L><E><P><I><W><N><E><V><G><L><E><M><K><S><I><G><S><P><V><K><V><G><K><M><D><A><T><S><Y><S><S><I><A><S><E><F><G><V><R><G><Y><P><T><I><K><L><L><K><G><D><L><A><Y><N><Y><R><G><P><R><T><K><D><D><I><I><E><F><A><H><R><V><S><G><A><L><I><R><P><L><P><S><Q><Q><M><F><E><H><M><Q><K><R><H><R><V><F><F><V><Y><V><G><G><E><S><P><L><K><E><K><Y><I><D><A><A><S><E><L><I><V><Y><T><Y><F><F><S><A><S><E><E><V><V><P><E><Y><V><T><L><K><E><M><P><A><V><L><V><F><K><D><E><T><Y><F><V><Y><D><E><Y><E><D><G><D><L><S><S><W><I><N><R><E><R><F><Q><N><Y><L><A><M><D><G><F><L><L><Y><E><L><G><D><T><G><K><L><V><A><L><A><V><I><D><E><K><N><T><S><V><E><H><T><R><L><K><S><I><I><Q><E><V><A><R><D><Y><R><D><L><F><H><R><D><F><Q><F><G><H><M><D><G><N><D><Y><I><N><T><L><L><M><D><E><L><T><V><P><T><V><V><V><L><N><T><S><N><Q><Q><Y><F><L><L><D><R><Q><I><K><N><V><E><D><M><V><Q><F><I><N><N><I><L><D><G><T><V><E><A><Q><G><G><D><S><I><L><Q><R><L><K><R><I><V><F><D><A><K><S><T><I><V><S><I><F><K><S><S><P><L><M><G><C><F><L><F><G><L><P><L><G><V><I><S><I><M><C><Y><G><I><Y><T><A><D><T><D><G><G><Y><I><E><E><R><Y><E><V><S><K><S><E><N><E><N><Q><E><Q><I><E><E><S><K><E><Q><Q><E><P><S><S><G><G><S><V><V><P><T><V><Q><E><P><K><D><V><L><E><K><K><K><D>
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Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase.<BOP>
|
Q96JJ7
|
P22626
|
ROA2_HUMAN
|
Heterogeneous nuclear ribonucleoproteins A2/B1
|
Homo
|
<M><E><K><T><L><E><T><V><P><L><E><R><K><K><R><E><K><E><Q><F><R><K><L><F><I><G><G><L><S><F><E><T><T><E><E><S><L><R><N><Y><Y><E><Q><W><G><K><L><T><D><C><V><V><M><R><D><P><A><S><K><R><S><R><G><F><G><F><V><T><F><S><S><M><A><E><V><D><A><A><M><A><A><R><P><H><S><I><D><G><R><V><V><E><P><K><R><A><V><A><R><E><E><S><G><K><P><G><A><H><V><T><V><K><K><L><F><V><G><G><I><K><E><D><T><E><E><H><H><L><R><D><Y><F><E><E><Y><G><K><I><D><T><I><E><I><I><T><D><R><Q><S><G><K><K><R><G><F><G><F><V><T><F><D><D><H><D><P><V><D><K><I><V><L><Q><K><Y><H><T><I><N><G><H><N><A><E><V><R><K><A><L><S><R><Q><E><M><Q><E><V><Q><S><S><R><S><G><R><G><G><N><F><G><F><G><D><S><R><G><G><G><G><N><F><G><P><G><P><G><S><N><F><R><G><G><S><D><G><Y><G><S><G><R><G><F><G><D><G><Y><N><G><Y><G><G><G><P><G><G><G><N><F><G><G><S><P><G><Y><G><G><G><R><G><G><Y><G><G><G><G><P><G><Y><G><N><Q><G><G><G><Y><G><G><G><Y><D><N><Y><G><G><G><N><Y><G><S><G><N><Y><N><D><F><G><N><Y><N><Q><Q><P><S><N><Y><G><P><M><K><S><G><N><F><G><G><S><R><N><M><G><G><P><Y><G><G><G><N><Y><G><P><G><G><S><G><G><S><G><G><Y><G><G><R><S><R><Y>
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(Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport.<BOP>
|
P22626
|
Q969P5
|
FBX32_HUMAN
|
Muscle atrophy F-box protein
|
Homo
|
<M><P><F><L><G><Q><D><W><R><S><P><G><Q><N><W><V><K><T><A><D><G><W><K><R><F><L><D><E><K><S><G><S><F><V><S><D><L><S><S><Y><C><N><K><E><V><Y><N><K><E><N><L><F><N><S><L><N><Y><D><V><A><A><K><K><R><K><K><D><M><L><N><S><K><T><K><T><Q><Y><F><H><Q><E><K><W><I><Y><V><H><K><G><S><T><K><E><R><H><G><Y><C><T><L><G><E><A><F><N><R><L><D><F><S><T><A><I><L><D><S><R><R><F><N><Y><V><V><R><L><L><E><L><I><A><K><S><Q><L><T><S><L><S><G><I><A><Q><K><N><F><M><N><I><L><E><K><V><V><L><K><V><L><E><D><Q><Q><N><I><R><L><I><R><E><L><L><Q><T><L><Y><T><S><L><C><T><L><V><Q><R><V><G><K><S><V><L><V><G><N><I><N><M><W><V><Y><R><M><E><T><I><L><H><W><Q><Q><Q><L><N><N><I><Q><I><T><R><P><A><F><K><G><L><T><F><T><D><L><P><L><C><L><Q><L><N><I><M><Q><R><L><S><D><G><R><D><L><V><S><L><G><Q><A><A><P><D><L><H><V><L><S><E><D><R><L><L><W><K><K><L><C><Q><Y><H><F><S><E><R><Q><I><R><K><R><L><I><L><S><D><K><G><Q><L><D><W><K><K><M><Y><F><K><L><V><R><C><Y><P><R><K><E><Q><Y><G><D><T><L><Q><L><C><K><H><C><H><I><L><S><W><K><G><T><D><H><P><C><T><A><N><N><P><E><S><C><S><V><S><L><S><P><Q><D><F><I><N><L><F><K><F>
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Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.<BOP>
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Q969P5
|
Q86TU7
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SETD3_HUMAN
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SET domain-containing protein 3
|
Homo
|
<M><G><K><K><S><R><V><K><T><Q><K><S><G><T><G><A><T><A><T><V><S><P><K><E><I><L><N><L><T><S><E><L><L><Q><K><C><S><S><P><A><P><G><P><G><K><E><W><E><E><Y><V><Q><I><R><T><L><V><E><K><I><R><K><K><Q><K><G><L><S><V><T><F><D><G><K><R><E><D><Y><F><P><D><L><M><K><W><A><S><E><N><G><A><S><V><E><G><F><E><M><V><N><F><K><E><E><G><F><G><L><R><A><T><R><D><I><K><A><E><E><L><F><L><W><V><P><R><K><L><L><M><T><V><E><S><A><K><N><S><V><L><G><P><L><Y><S><Q><D><R><I><L><Q><A><M><G><N><I><A><L><A><F><H><L><L><C><E><R><A><S><P><N><S><F><W><Q><P><Y><I><Q><T><L><P><S><E><Y><D><T><P><L><Y><F><E><E><D><E><V><R><Y><L><Q><S><T><Q><A><I><H><D><V><F><S><Q><Y><K><N><T><A><R><Q><Y><A><Y><F><Y><K><V><I><Q><T><H><P><H><A><N><K><L><P><L><K><D><S><F><T><Y><E><D><Y><R><W><A><V><S><S><V><M><T><R><Q><N><Q><I><P><T><E><D><G><S><R><V><T><L><A><L><I><P><L><W><D><M><C><N><H><T><N><G><L><I><T><T><G><Y><N><L><E><D><D><R><C><E><C><V><A><L><Q><D><F><R><A><G><E><Q><I><Y><I><F><Y><G><T><R><S><N><A><E><F><V><I><H><S><G><F><F><F><D><N><N><S><H><D><R><V><K><I><K><L><G><V><S><K><S><D><R><L><Y><A><M><K><A><E><V><L><A><R><A><G><I><P><T><S><S><V><F><A><L><H><F><T><E><P><P><I><S><A><Q><L><L><A><F><L><R><V><F><C><M><T><E><E><E><L><K><E><H><L><L><G><D><S><A><I><D><R><I><F><T><L><G><N><S><E><F><P><V><S><W><D><N><E><V><K><L><W><T><F><L><E><D><R><A><S><L><L><L><K><T><Y><K><T><T><I><E><E><D><K><S><V><L><K><N><H><D><L><S><V><R><A><K><M><A><I><K><L><R><L><G><E><K><E><I><L><E><K><A><V><K><S><A><A><V><N><R><E><Y><Y><R><Q><Q><M><E><E><K><A><P><L><P><K><Y><E><E><S><N><L><G><L><L><E><S><S><V><G><D><S><R><L><P><L><V><L><R><N><L><E><E><E><A><G><V><Q><D><A><L><N><I><R><E><A><I><S><K><A><K><A><T><E><N><G><L><V><N><G><E><N><S><I><P><N><G><T><R><S><E><N><E><S><L><N><Q><E><S><K><R><A><V><E><D><A><K><G><S><S><S><D><S><T><A><G><V><K><E>
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Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' . Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery . Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin .<BOP>
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Q86TU7
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P0C8F1
|
PATE4_HUMAN
|
PATE-like protein B
|
Homo
|
<M><R><K><M><N><T><L><L><L><V><S><L><S><F><L><Y><L><K><E><V><M><G><L><K><C><N><T><C><I><Y><T><E><G><W><K><C><M><A><G><R><G><T><C><I><A><K><E><N><E><L><C><S><T><T><A><Y><F><R><G><D><K><H><M><Y><S><T><H><M><C><K><Y><K><C><R><E><E><E><S><S><K><R><G><L><L><R><V><T><L><C><C><D><R><N><F><C><N><V><F>
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May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility.<BOP>
|
P0C8F1
|
Q8NA31
|
TERB1_HUMAN
|
Coiled-coil domain-containing protein 79
|
Homo
|
<M><E><S><E><D><T><K><K><T><Q><E><M><K><T><D><L><N><L><L><L><E><C><L><K><Y><Q><M><D><N><A><F><S><Q><K><E><A><L><V><T><I><H><S><I><C><Q><Q><N><S><N><A><S><V><Y><F><R><E><I><G><G><L><M><F><V><K><N><L><A><K><S><S><E><H><S><M><V><K><E><A><A><L><Y><T><L><G><A><I><A><E><K><N><V><Y><C><Q><Q><T><L><C><T><S><E><L><F><E><D><L><T><W><F><L><S><N><D><S><N><I><N><L><K><R><M><S><V><Y><V><I><L><V><L><V><S><N><N><R><T><G><Q><T><L><V><R><E><T><G><C><I><T><V><L><S><R><L><F><R><T><V><I><S><K><H><E><L><D><L><S><D><K><N><V><F><Q><S><Y><Q><L><W><S><S><V><C><S><T><L><C><V><C><V><N><N><P><Q><N><D><E><N><Q><M><F><C><C><S><L><F><P><H><A><N><E><W><L><K><N><C><T><T><P><E><I><I><R><P><I><C><S><F><I><G><L><T><L><A><N><N><T><Y><V><Q><K><Y><F><V><S><V><G><G><L><D><V><L><S><Q><V><L><M><Q><L><E><S><D><S><H><E><T><L><S><S><A><K><L><A><V><V><V><T><K><T><V><D><A><C><I><A><D><N><P><T><F><G><I><V><L><S><K><Y><H><I><V><S><K><L><L><A><L><L><L><H><E><S><L><D><S><G><E><K><F><S><I><M><L><T><L><G><H><C><T><E><D><C><E><E><N><Q><Y><D><L><F><K><N><N><G><L><P><L><M><I><Q><A><L><T><E><S><Q><N><E><E><L><N><K><A><A><T><F><V><L><H><N><C><K><K><I><T><E><K><L><S><L><S><L><G><E><Y><P><F><D><E><N><E><T><Q><Q><L><K><D><I><S><V><K><E><N><N><L><E><E><H><W><R><K><A><K><E><I><L><H><R><I><E><Q><L><E><R><E><G><N><E><E><E><I><Q><R><E><N><Y><Q><D><N><I><S><S><M><N><I><S><I><Q><N><T><W><K><H><L><H><A><D><R><I><G><R><G><S><K><A><E><D><E><D><K><S><H><S><R><Q><L><Q><S><Y><K><S><H><G><V><M><S><K><A><C><T><N><D><D><Q><M><K><T><P><L><K><S><A><N><P><V><H><A><C><Y><R><E><S><E><Q><N><K><T><L><Y><K><A><K><S><S><C><N><Q><N><L><H><E><E><T><T><F><E><K><N><F><V><S><Q><S><S><D><H><V><F><K><H><P><V><H><I><A><K><N><I><K><Q><Q><L><P><V><T><D><P><F><T><L><C><S><D><I><I><N><K><E><V><V><S><F><L><A><T><P><S><C><S><E><M><L><T><Y><R><C><S><G><C><I><A><V><E><K><S><L><N><S><R><N><F><S><K><L><L><H><S><C><P><Y><Q><C><D><R><H><K><V><I><V><E><A><E><D><R><Y><K><S><E><L><R><K><S><L><I><C><N><K><K><I><L><L><T><P><R><R><R><Q><R><L><S><N><E><S><T><T><P><G><G><I><K><K><R><R><I><R><K><N><F><T><E><E><E><V><N><Y><L><F><N><G><V><K><K><M><G><N><H><W><N><S><I><L><W><S><F><P><F><Q><Q><G><R><K><A><V><D><L><A><H><K><Y><H><K><L><T><K><H><P><T><C><A><A><S>
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Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.<BOP>
|
Q8NA31
|
Q9BSB4
|
ATGA1_HUMAN
|
Autophagy-related protein 101
|
Homo
|
<M><N><C><R><S><E><V><L><E><V><S><V><E><G><R><Q><V><E><E><A><M><L><A><V><L><H><T><V><L><L><H><R><S><T><G><K><F><H><Y><K><K><E><G><T><Y><S><I><G><T><V><G><T><Q><D><V><D><C><D><F><I><D><F><T><Y><V><R><V><S><S><E><E><L><D><R><A><L><R><K><V><V><G><E><F><K><D><A><L><R><N><S><G><G><D><G><L><G><Q><M><S><L><E><F><Y><Q><K><K><K><S><R><W><P><F><S><D><E><C><I><P><W><E><V><W><T><V><K><V><H><V><V><A><L><A><T><E><Q><E><R><Q><I><C><R><E><K><V><G><E><K><L><C><E><K><I><I><N><I><V><E><V><M><N><R><H><E><Y><L><P><K><M><P><T><Q><S><E><V><D><N><V><F><D><T><G><L><R><D><V><Q><P><Y><L><Y><K><I><S><F><Q><I><T><D><A><L><G><T><S><V><T><T><T><M><R><R><L><I><K><D><T><L><A><L>
|
Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.<BOP>
|
Q9BSB4
|
P53801
|
PTTG_HUMAN
|
Pituitary tumor-transforming gene protein-binding factor
|
Homo
|
<M><A><P><G><V><A><R><G><P><T><P><Y><W><R><L><R><L><G><G><A><A><L><L><L><L><L><I><P><V><A><A><A><Q><E><P><P><G><A><A><C><S><Q><N><T><N><K><T><C><E><E><C><L><K><N><V><S><C><L><W><C><N><T><N><K><A><C><L><D><Y><P><V><T><S><V><L><P><P><A><S><L><C><K><L><S><S><A><R><W><G><V><C><W><V><N><F><E><A><L><I><I><T><M><S><V><V><G><G><T><L><L><L><G><I><A><I><C><C><C><C><C><C><R><R><K><R><S><R><K><P><D><R><S><E><E><K><A><M><R><E><R><E><E><R><R><I><R><Q><E><E><R><R><A><E><M><K><T><R><H><D><E><I><R><K><K><Y><G><L><F><K><E><E><N><P><Y><A><R><F><E><N><N>
|
May facilitate PTTG1 nuclear translocation.<BOP>
|
P53801
|
Q8NGA6
|
O10H5_HUMAN
|
Olfactory receptor OR19-26
|
Homo
|
<M><Q><G><L><N><H><T><S><V><S><E><F><I><L><V><G><F><S><A><F><P><H><L><Q><L><M><L><F><L><L><F><L><L><M><Y><L><F><T><L><L><G><N><L><L><I><M><A><T><V><W><S><E><R><S><L><H><M><P><M><Y><L><F><L><C><A><L><S><I><T><E><I><L><Y><T><V><A><I><I><P><R><M><L><A><D><L><L><S><T><Q><R><S><I><A><F><L><A><C><A><S><Q><M><F><F><S><F><S><F><G><F><T><H><S><F><L><L><T><V><M><G><Y><D><R><Y><V><A><I><C><H><P><L><R><Y><N><V><L><M><S><L><R><G><C><T><C><R><V><G><C><S><W><A><G><G><L><V><M><G><M><V><V><T><S><A><I><F><H><L><A><F><C><G><H><K><E><I><H><H><F><F><C><H><V><P><P><L><L><K><L><A><C><G><D><D><V><L><V><V><A><K><G><V><G><L><V><C><I><T><A><L><L><G><C><F><L><L><I><L><L><S><Y><A><F><I><V><A><A><I><L><K><I><P><S><A><E><G><R><N><K><A><F><S><T><C><A><S><H><L><T><V><V><V><V><H><Y><G><F><A><S><V><I><Y><L><K><P><K><G><P><Q><S><P><E><G><D><T><L><M><G><I><T><Y><T><V><L><T><P><F><L><S><P><I><I><F><S><L><R><N><K><E><L><K><V><A><M><K><K><T><C><F><T><K><L><F><P><Q><N><C>
|
Odorant receptor.<BOP>
|
Q8NGA6
|
P24071
|
FCAR_HUMAN
|
Immunoglobulin alpha Fc receptor
|
Homo
|
<M><D><P><K><Q><T><T><L><L><C><L><V><L><C><L><G><Q><R><I><Q><A><Q><E><G><D><F><P><M><P><F><I><S><A><K><S><S><P><V><I><P><L><D><G><S><V><K><I><Q><C><Q><A><I><R><E><A><Y><L><T><Q><L><M><I><I><K><N><S><T><Y><R><E><I><G><R><R><L><K><F><W><N><E><T><D><P><E><F><V><I><D><H><M><D><A><N><K><A><G><R><Y><Q><C><Q><Y><R><I><G><H><Y><R><F><R><Y><S><D><T><L><E><L><V><V><T><G><L><Y><G><K><P><F><L><S><A><D><R><G><L><V><L><M><P><G><E><N><I><S><L><T><C><S><S><A><H><I><P><F><D><R><F><S><L><A><K><E><G><E><L><S><L><P><Q><H><Q><S><G><E><H><P><A><N><F><S><L><G><P><V><D><L><N><V><S><G><I><Y><R><C><Y><G><W><Y><N><R><S><P><Y><L><W><S><F><P><S><N><A><L><E><L><V><V><T><D><S><I><H><Q><D><Y><T><T><Q><N><L><I><R><M><A><V><A><G><L><V><L><V><A><L><L><A><I><L><V><E><N><W><H><S><H><T><A><L><N><K><E><A><S><A><D><V><A><E><P><S><W><S><Q><Q><M><C><Q><P><G><L><T><F><A><R><T><P><S><V><C><K>
|
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.<BOP>
|
P24071
|
Q8N531
|
FBXL6_HUMAN
|
FBL6A
|
Homo
|
<M><A><A><P><A><S><R><Q><V><R><R><R><A><R><A><A><P><R><P><R><S><A><E><D><W><W><W><D><R><L><A><P><R><G><S><G><Y><H><L><L><Q><S><D><S><M><L><L><V><L><S><E><P><G><P><A><R><P><R><A><Q><R><R><A><S><R><R><T><P><R><Q><P><P><R><G><P><S><A><A><A><K><P><K><A><G><L><R><S><E><A><A><A><A><P><A><P><A><P><A><P><T><P><T><P><E><E><G><P><D><A><G><W><G><D><R><I><P><L><E><I><L><V><Q><I><F><G><L><L><V><A><A><D><G><P><M><P><F><L><G><R><A><A><R><V><C><R><R><W><Q><E><A><A><S><Q><P><A><L><W><H><T><V><T><L><S><S><P><L><V><G><R><P><A><K><G><G><V><K><A><E><K><K><L><L><A><S><L><E><W><L><M><P><N><R><F><S><Q><L><Q><R><L><T><L><I><H><W><K><S><Q><V><H><P><V><L><K><L><V><G><E><C><C><P><R><L><T><F><L><K><L><S><G><C><H><G><V><T><A><D><A><L><V><M><L><A><K><A><C><C><Q><L><H><S><L><D><L><Q><H><S><M><V><E><S><T><A><V><V><S><F><L><E><E><A><G><S><R><M><R><K><L><W><L><T><Y><S><S><Q><T><T><A><I><L><G><A><L><L><G><S><C><C><P><Q><L><Q><V><L><E><V><S><T><G><I><N><R><N><S><I><P><L><Q><L><P><V><E><A><L><Q><K><G><C><P><Q><L><Q><V><L><R><L><L><N><L><M><W><L><P><K><P><P><G><R><G><V><A><P><G><P><G><F><P><S><L><E><E><L><C><L><A><S><S><T><C><N><F><V><S><N><E><V><L><G><R><L><L><H><G><S><P><N><L><R><L><L><D><L><R><G><C><A><R><I><T><P><A><G><L><Q><D><L><P><C><R><E><L><E><Q><L><H><L><G><L><Y><G><T><S><D><R><L><T><L><A><K><E><G><S><P><F><L><T><Q><K><W><C><H><T><L><R><E><L><D><L><S><G><Q><G><F><S><E><K><D><L><E><Q><A><L><A><A><F><L><S><T><P><G><G><S><H><P><A><L><C><S><L><N><L><R><G><T><R><V><T><P><S><T><V><S><S><V><I><S><G><C><P><G><L><L><Y><L><N><L><E><S><C><R><C><L><P><R><G><L><K><R><A><Y><R><G><L><E><E><V><Q><W><C><L><E><Q><L><L><T><S><P><S><P><S>
|
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP>
|
Q8N531
|
O75379
|
VAMP4_HUMAN
|
Vesicle-associated membrane protein 4
|
Homo
|
<M><P><P><K><F><K><R><H><L><N><D><D><D><V><T><G><S><V><K><S><E><R><R><N><L><L><E><D><D><S><D><E><E><E><D><F><F><L><R><G><P><S><G><P><R><F><G><P><R><N><D><K><I><K><H><V><Q><N><Q><V><D><E><V><I><D><V><M><Q><E><N><I><T><K><V><I><E><R><G><E><R><L><D><E><L><Q><D><K><S><E><S><L><S><D><N><A><T><A><F><S><N><R><S><K><Q><L><R><R><Q><M><W><W><R><G><C><K><I><K><A><I><M><A><L><V><A><A><I><L><L><L><V><I><I><I><L><I><V><M><K><Y><R><T>
|
Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.<BOP>
|
O75379
|
Q8NH57
|
O52P1_HUMAN
|
Olfactory receptor 52P1
|
Homo
|
<M><E><S><P><N><H><T><D><V><D><P><S><V><F><F><L><L><G><I><P><G><L><E><Q><F><H><L><W><L><S><L><P><V><C><G><L><G><T><A><T><I><V><G><N><I><T><I><L><V><V><V><A><T><E><P><V><L><H><K><P><V><Y><L><F><L><C><M><L><S><T><I><D><L><A><A><S><V><S><T><V><P><K><L><L><A><I><F><W><C><G><A><G><H><I><S><A><S><A><C><L><A><Q><M><F><F><I><H><A><F><C><M><M><E><S><T><V><L><L><A><M><A><F><D><R><Y><V><A><I><C><H><P><L><R><Y><A><T><I><L><T><D><T><I><I><A><H><I><G><V><A><A><V><V><R><G><S><L><L><M><L><P><C><P><F><L><I><G><R><L><N><F><C><Q><S><H><V><I><L><H><T><Y><C><E><H><M><A><V><V><K><L><A><C><G><D><T><R><P><N><R><V><Y><G><L><T><A><A><L><L><V><I><G><V><D><L><F><C><I><G><L><S><Y><A><L><S><A><Q><A><V><L><R><L><S><S><H><E><A><R><S><K><A><L><G><T><C><G><S><H><V><C><V><I><L><I><S><Y><T><P><A><L><F><S><F><F><T><H><R><F><G><H><H><V><P><V><H><I><H><I><L><L><A><N><V><Y><L><L><L><P><P><A><L><N><P><V><V><Y><G><V><K><T><K><Q><I><R><K><R><V><V><R><V><F><Q><S><G><Q><G><M><G><I><K><A><S><E>
|
Odorant receptor.<BOP>
|
Q8NH57
|
A9YTQ3
|
AHRR_HUMAN
|
Class E basic helix-loop-helix protein 77
|
Homo
|
<M><P><R><T><M><I><P><P><G><E><C><T><Y><A><G><R><K><R><R><R><P><L><Q><K><Q><R><P><A><V><G><A><E><K><S><N><P><S><K><R><H><R><D><R><L><N><A><E><L><D><H><L><A><S><L><L><P><F><P><P><D><I><I><S><K><L><D><K><L><S><V><L><R><L><S><V><S><Y><L><R><V><K><S><F><F><Q><V><V><Q><E><Q><S><S><R><Q><P><A><A><G><A><P><S><P><G><D><S><C><P><L><A><G><S><A><V><L><E><G><R><L><L><L><E><S><L><N><G><F><A><L><V><V><S><A><E><G><T><I><F><Y><A><S><A><T><I><V><D><Y><L><G><F><H><Q><T><D><V><M><H><Q><N><I><Y><D><Y><I><H><V><D><D><R><Q><D><F><C><R><Q><L><H><W><A><M><D><P><P><Q><V><V><F><G><Q><P><P><P><L><E><T><G><D><D><A><I><L><G><R><L><L><R><A><Q><E><W><G><T><G><T><P><T><E><Y><S><A><F><L><T><R><C><F><I><C><R><V><R><C><L><L><D><S><T><S><G><F><L><T><M><Q><F><Q><G><K><L><K><F><L><F><G><Q><K><K><K><A><P><S><G><A><M><L><P><P><R><L><S><L><F><C><I><A><A><P><V><L><L><P><S><A><A><E><M><K><M><R><S><A><L><L><R><A><K><P><R><A><D><T><A><A><T><A><D><A><K><V><K><A><T><T><S><L><C><E><S><E><L><H><G><K><P><N><Y><S><A><G><R><S><S><R><E><S><G><V><L><V><L><R><E><Q><T><D><A><G><R><W><A><Q><V><P><A><R><A><P><C><L><C><L><R><G><G><P><D><L><V><L><D><P><K><G><G><S><G><D><R><E><E><E><Q><H><R><M><L><S><R><A><S><G><V><T><G><R><R><E><T><P><G><P><T><K><P><L><P><W><T><A><G><K><H><S><E><D><G><A><R><P><R><L><Q><P><S><K><N><D><P><P><S><L><R><P><M><P><R><G><S><C><L><P><C><P><C><V><Q><G><T><F><R><N><S><P><I><S><H><P><P><S><P><S><P><S><A><Y><S><S><R><T><S><R><P><M><R><D><V><G><E><D><Q><V><H><P><P><L><C><H><F><P><Q><R><S><L><Q><H><Q><L><P><Q><P><G><A><Q><R><F><A><T><R><G><Y><P><M><E><D><M><K><L><Q><G><V><P><M><P><P><G><D><L><C><G><P><T><L><L><L><D><V><S><I><K><M><E><K><D><S><G><C><E><G><A><A><D><G><C><V><P><S><Q><V><W><L><G><A><S><D><R><S><H><P><A><T><F><P><T><R><M><H><L><K><T><E><P><D><S><R><Q><Q><V><Y><I><S><H><L><G><H><G><V><R><G><A><Q><P><H><G><R><A><T><A><G><R><S><R><E><L><T><P><F><H><P><A><H><C><A><C><L><E><P><T><D><G><L><P><Q><S><E><P><P><H><Q><L><C><A><R><G><R><G><E><Q><S><C><T><C><R><A><A><E><A><A><P><V><V><K><R><E><P><L><D><S><P><Q><W><A><T><H><S><Q><G><M><V><P><G><M><L><P><K><S><A><L><A><T><L><V><P><P><Q><A><S><G><C><T><F><L><P>
|
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.<BOP>
|
A9YTQ3
|
Q7Z3Y8
|
K1C27_HUMAN
|
Type I inner root sheath-specific keratin-K25irs3
|
Homo
|
<M><S><V><R><F><S><S><T><S><R><R><L><G><S><C><G><G><T><G><S><V><R><L><S><S><G><G><A><G><F><G><A><G><N><T><C><G><V><P><G><I><G><S><G><F><S><C><A><F><G><G><S><S><S><A><G><G><Y><G><G><G><L><G><G><G><S><A><S><C><A><A><F><T><G><N><E><H><G><L><L><S><G><N><E><K><V><T><M><Q><N><L><N><D><R><L><A><S><Y><L><E><N><V><R><A><L><E><E><A><N><A><D><L><E><Q><K><I><K><G><W><Y><E><K><F><G><P><G><S><C><R><G><L><D><H><D><Y><S><R><Y><F><P><I><I><D><E><L><K><N><Q><I><I><S><A><T><T><S><N><A><H><V><V><L><Q><N><D><N><A><R><L><T><A><D><D><F><R><L><K><F><E><N><E><L><A><L><H><Q><S><V><E><A><D><I><N><G><L><R><R><V><L><D><E><L><T><L><C><R><T><D><L><E><I><Q><L><E><T><L><S><E><E><L><A><Y><L><K><K><N><H><E><E><E><M><K><A><L><Q><C><A><A><G><G><N><V><N><V><E><M><N><A><A><P><G><V><D><L><T><V><L><L><N><N><M><R><A><E><Y><E><A><L><A><E><Q><N><R><R><D><A><E><A><W><F><N><E><K><S><A><S><L><Q><Q><Q><I><S><D><D><A><G><A><T><T><S><A><R><N><E><L><I><E><M><K><R><T><L><Q><T><L><E><I><E><L><Q><S><L><L><A><T><K><H><S><L><E><C><S><L><T><E><T><E><S><N><Y><C><A><Q><L><A><Q><I><Q><A><Q><I><G><A><L><E><E><Q><L><H><Q><V><R><T><E><T><E><G><Q><K><L><E><Y><E><Q><L><L><D><I><K><V><H><L><E><K><E><I><E><T><Y><C><L><L><I><D><G><E><D><G><S><C><S><K><S><K><G><Y><G><G><P><G><N><Q><T><K><D><S><S><K><T><T><I><V><K><T><V><V><E><E><I><D><P><R><G><K><V><L><S><S><R><V><H><T><V><E><E><K><S><T><K><V><N><N><K><N><E><Q><R><V><S><S>
|
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).<BOP>
|
Q7Z3Y8
|
P56377
|
AP1S2_HUMAN
|
Sigma1B-adaptin
|
Homo
|
<M><Q><F><M><L><L><F><S><R><Q><G><K><L><R><L><Q><K><W><Y><V><P><L><S><D><K><E><K><K><K><I><T><R><E><L><V><Q><T><V><L><A><R><K><P><K><M><C><S><F><L><E><W><R><D><L><K><I><V><Y><K><R><Y><A><S><L><Y><F><C><C><A><I><E><D><Q><D><N><E><L><I><T><L><E><I><I><H><R><Y><V><E><L><L><D><K><Y><F><G><S><V><C><E><L><D><I><I><F><N><F><E><K><A><Y><F><I><L><D><E><F><L><L><G><G><E><V><Q><E><T><S><K><K><N><V><L><K><A><I><E><Q><A><D><L><L><Q><E><E><A><E><T><P><R><S><V><L><E><E><I><G><L><T>
|
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.<BOP>
|
P56377
|
O60683
|
PEX10_HUMAN
|
RING finger protein 69
|
Homo
|
<M><A><P><A><A><A><S><P><P><E><V><I><R><A><A><Q><K><D><E><Y><Y><R><G><G><L><R><S><A><A><G><G><A><L><H><S><L><A><G><A><R><K><W><L><E><W><R><K><E><V><E><L><L><S><D><V><A><Y><F><G><L><T><T><L><A><G><Y><Q><T><L><G><E><E><Y><V><S><I><I><Q><V><D><P><S><R><I><H><V><P><S><S><L><R><R><G><V><L><V><T><L><H><A><V><L><P><Y><L><L><D><K><A><L><L><P><L><E><Q><E><L><Q><A><D><P><D><S><G><R><P><L><Q><G><S><L><G><P><G><G><R><G><C><S><G><A><R><R><W><M><R><H><H><T><A><T><L><T><E><Q><Q><R><R><A><L><L><R><A><V><F><V><L><R><Q><G><L><A><C><L><Q><R><L><H><V><A><W><F><Y><I><H><G><V><F><Y><H><L><A><K><R><L><T><G><I><T><Y><L><R><V><R><S><L><P><G><E><D><L><R><A><R><V><S><Y><R><L><L><G><V><I><S><L><L><H><L><V><L><S><M><G><L><Q><L><Y><G><F><R><Q><R><Q><R><A><R><K><E><W><R><L><H><R><G><L><S><H><R><R><A><S><L><E><E><R><A><V><S><R><N><P><L><C><T><L><C><L><E><E><R><R><H><P><T><A><T><P><C><G><H><L><F><C><W><E><C><I><T><A><W><C><S><S><K><A><E><C><P><L><C><R><E><K><F><P><P><Q><K><L><I><Y><L><R><H><Y><R>
|
Somewhat implicated in the biogenesis of peroxisomes.<BOP>
|
O60683
|
A0A0B4J245
|
TVAL1_HUMAN
|
T cell receptor alpha variable 12-1
|
Homo
|
<M><I><S><L><R><V><L><L><V><I><L><W><L><Q><L><S><W><V><W><S><Q><R><K><E><V><E><Q><D><P><G><P><F><N><V><P><E><G><A><T><V><A><F><N><C><T><Y><S><N><S><A><S><Q><S><F><F><W><Y><R><Q><D><C><R><K><E><P><K><L><L><M><S><V><Y><S><S><G><N><E><D><G><R><F><T><A><Q><L><N><R><A><S><Q><Y><I><S><L><L><I><R><D><S><K><L><S><D><S><A><T><Y><L><C><V><V><N>
|
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
|
A0A0B4J245
|
P08319
|
ADH4_HUMAN
|
Alcohol dehydrogenase class II pi chain
|
Homo
|
<M><G><T><K><G><K><V><I><K><C><K><A><A><I><A><W><E><A><G><K><P><L><C><I><E><E><V><E><V><A><P><P><K><A><H><E><V><R><I><Q><I><I><A><T><S><L><C><H><T><D><A><T><V><I><D><S><K><F><E><G><L><A><F><P><V><I><V><G><H><E><A><A><G><I><V><E><S><I><G><P><G><V><T><N><V><K><P><G><D><K><V><I><P><L><Y><A><P><L><C><R><K><C><K><F><C><L><S><P><L><T><N><L><C><G><K><I><S><N><L><K><S><P><A><S><D><Q><Q><L><M><E><D><K><T><S><R><F><T><C><K><G><K><P><V><Y><H><F><F><G><T><S><T><F><S><Q><Y><T><V><V><S><D><I><N><L><A><K><I><D><D><D><A><N><L><E><R><V><C><L><L><G><C><G><F><S><T><G><Y><G><A><A><I><N><N><A><K><V><T><P><G><S><T><C><A><V><F><G><L><G><G><V><G><L><S><A><V><M><G><C><K><A><A><G><A><S><R><I><I><G><I><D><I><N><S><E><K><F><V><K><A><K><A><L><G><A><T><D><C><L><N><P><R><D><L><H><K><P><I><Q><E><V><I><I><E><L><T><K><G><G><V><D><F><A><L><D><C><A><G><G><S><E><T><M><K><A><A><L><D><C><T><T><A><G><W><G><S><C><T><F><I><G><V><A><A><G><S><K><G><L><T><I><F><P><E><E><L><I><I><G><R><T><I><N><G><T><F><F><G><G><W><K><S><V><D><S><I><P><K><L><V><T><D><Y><K><N><K><K><F><N><L><D><A><L><V><T><H><T><L><P><F><D><K><I><S><E><A><F><D><L><M><N><Q><G><K><S><V><R><T><I><L><I><F>
|
Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol . Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate . Also catalyzes the reduction of benzoquinones .<BOP>
|
P08319
|
O15287
|
FANCG_HUMAN
|
DNA repair protein XRCC9
|
Homo
|
<M><S><R><Q><T><T><S><V><G><S><S><C><L><D><L><W><R><E><K><N><D><R><L><V><R><Q><A><K><V><A><Q><N><S><G><L><T><L><R><R><Q><Q><L><A><Q><D><A><L><E><G><L><R><G><L><L><H><S><L><Q><G><L><P><A><A><V><P><V><L><P><L><E><L><T><V><T><C><N><F><I><I><L><R><A><S><L><A><Q><G><F><T><E><D><Q><A><Q><D><I><Q><R><S><L><E><R><V><L><E><T><Q><E><Q><Q><G><P><R><L><E><Q><G><L><R><E><L><W><D><S><V><L><R><A><S><C><L><L><P><E><L><L><S><A><L><H><R><L><V><G><L><Q><A><A><L><W><L><S><A><D><R><L><G><D><L><A><L><L><L><E><T><L><N><G><S><Q><S><G><A><S><K><D><L><L><L><L><L><K><T><W><S><P><P><A><E><E><L><D><A><P><L><T><L><Q><D><A><Q><G><L><K><D><V><L><L><T><A><F><A><Y><R><Q><G><L><Q><E><L><I><T><G><N><P><D><K><A><L><S><S><L><H><E><A><A><S><G><L><C><P><R><P><V><L><V><Q><V><Y><T><A><L><G><S><C><H><R><K><M><G><N><P><Q><R><A><L><L><Y><L><V><A><A><L><K><E><G><S><A><W><G><P><P><L><L><E><A><S><R><L><Y><Q><Q><L><G><D><T><T><A><E><L><E><S><L><E><L><L><V><E><A><L><N><V><P><C><S><S><K><A><P><Q><F><L><I><E><V><E><L><L><L><P><P><P><D><L><A><S><P><L><H><C><G><T><Q><S><Q><T><K><H><I><L><A><S><R><C><L><Q><T><G><R><A><G><D><A><A><E><H><Y><L><D><L><L><A><L><L><L><D><S><S><E><P><R><F><S><P><P><P><S><P><P><G><P><C><M><P><E><V><F><L><E><A><A><V><A><L><I><Q><A><G><R><A><Q><D><A><L><T><L><C><E><E><L><L><S><R><T><S><S><L><L><P><K><M><S><R><L><W><E><D><A><R><K><G><T><K><E><L><P><Y><C><P><L><W><V><S><A><T><H><L><L><Q><G><Q><A><W><V><Q><L><G><A><Q><K><V><A><I><S><E><F><S><R><C><L><E><L><L><F><R><A><T><P><E><E><K><E><Q><G><A><A><F><N><C><E><Q><G><C><K><S><D><A><A><L><Q><Q><L><R><A><A><A><L><I><S><R><G><L><E><W><V><A><S><G><Q><D><T><K><A><L><Q><D><F><L><L><S><V><Q><M><C><P><G><N><R><D><T><Y><F><H><L><L><Q><T><L><K><R><L><D><R><R><D><E><A><T><A><L><W><W><R><L><E><A><Q><T><K><G><S><H><E><D><A><L><W><S><L><P><L><Y><L><E><S><Y><L><S><W><I><R><P><S><D><R><D><A><F><L><E><E><F><R><T><S><L><P><K><S><C><D><L>
|
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.<BOP>
|
O15287
|
O43598
|
DNPH1_HUMAN
|
c-Myc-responsive protein RCL
|
Homo
|
<M><A><A><A><M><V><P><G><R><S><E><S><W><E><R><G><E><P><G><R><P><A><L><Y><F><C><G><S><I><R><G><G><R><E><D><R><T><L><Y><E><R><I><V><S><R><L><R><R><F><G><T><V><L><T><E><H><V><A><A><A><E><L><G><A><R><G><E><E><A><A><G><G><D><R><L><I><H><E><Q><D><L><E><W><L><Q><Q><A><D><V><V><V><A><E><V><T><Q><P><S><L><G><V><G><Y><E><L><G><R><A><V><A><F><N><K><R><I><L><C><L><F><R><P><Q><S><G><R><V><L><S><A><M><I><R><G><A><A><D><G><S><R><F><Q><V><W><D><Y><E><E><G><E><V><E><A><L><L><D><R><Y><F><E><A><D><P><P><G><Q><V><A><A><S><P><D><P><T><T>
|
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.<BOP>
|
O43598
|
Q7L2Z9
|
CENPQ_HUMAN
|
Centromere protein Q
|
Homo
|
<M><S><G><K><A><N><A><S><K><K><N><A><Q><Q><L><K><R><N><P><K><R><K><K><D><N><E><E><V><V><L><S><E><N><K><V><R><N><T><V><K><K><N><K><N><H><L><K><D><L><S><S><E><G><Q><T><K><H><T><N><L><K><H><G><K><T><A><A><S><K><R><K><T><W><Q><P><L><S><K><S><T><R><D><H><L><Q><T><M><M><E><S><V><I><M><T><I><L><S><N><S><I><K><E><K><E><E><I><Q><Y><H><L><N><F><L><K><K><R><L><L><Q><Q><C><E><T><L><K><V><P><P><K><K><M><E><D><L><T><N><V><S><S><L><L><N><M><E><R><A><R><D><K><A><N><E><E><G><L><A><L><L><Q><E><E><I><D><K><M><V><E><T><T><E><L><M><T><G><N><I><Q><S><L><K><N><K><I><Q><I><L><A><S><E><V><E><E><E><E><E><R><V><K><Q><M><H><Q><I><N><S><S><G><V><L><S><L><P><E><L><S><Q><K><T><L><K><A><P><T><L><Q><K><E><I><L><A><L><I><P><N><Q><N><A><L><L><K><D><L><D><I><L><H><N><S><S><Q><M><K><S><M><S><T><F><I><E><E><A><Y><K><K><L><D><A><S>
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Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex . Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores .<BOP>
|
Q7L2Z9
|
Q9NV29
|
TM100_HUMAN
|
Transmembrane protein 100
|
Homo
|
<M><T><E><E><P><I><K><E><I><L><G><A><P><K><A><H><M><A><A><T><M><E><K><S><P><K><S><E><V><V><I><T><T><V><P><L><V><S><E><I><Q><L><M><A><A><T><G><G><T><E><L><S><C><Y><R><C><I><I><P><F><A><V><V><V><F><I><A><G><I><V><V><T><A><V><A><Y><S><F><N><S><H><G><S><I><I><S><I><F><G><L><V><V><L><S><S><G><L><F><L><L><A><S><S><A><L><C><W><K><V><R><Q><R><S><K><K><A><K><R><R><E><S><Q><T><A><L><V><A><N><Q><R><S><L><F><A>
|
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.<BOP>
|
Q9NV29
|
Q8WV07
|
LTO1_HUMAN
|
Tumor-amplified and overexpressed sequence 1
|
Homo
|
<M><A><G><S><Q><D><I><F><D><A><I><V><M><A><D><E><R><F><H><G><E><G><Y><R><E><G><Y><E><E><G><S><S><L><G><V><M><E><G><R><Q><H><G><T><L><H><G><A><K><I><G><S><E><I><G><C><Y><Q><G><F><A><F><A><W><K><C><L><L><H><S><C><T><T><E><K><D><S><R><K><M><K><V><L><E><S><L><I><G><M><I><Q><K><F><P><Y><D><D><P><T><Y><D><K><L><H><E><D><L><D><K><I><R><G><K><F><K><Q><F><C><S><L><L><N><V><Q><P><D><F><K><I><S><A><E><G><S><G><L><S><F>
|
The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery . May be required for biogenesis of the large ribosomal subunit and initiation of translation . May play a role in the regulation of proline metabolism and ROS production .<BOP>
|
Q8WV07
|
Q9H2A9
|
CHST8_HUMAN
|
N-acetylgalactosamine-4-O-sulfotransferase 1
|
Homo
|
<M><T><L><R><P><G><T><M><R><L><A><C><M><F><S><S><I><L><L><F><G><A><A><G><L><L><L><F><I><S><L><Q><D><P><T><E><L><A><P><Q><Q><V><P><G><I><K><F><N><I><R><P><R><Q><P><H><H><D><L><P><P><G><G><S><Q><D><G><D><L><K><E><P><T><E><R><V><T><R><D><L><S><S><G><A><P><R><G><R><N><L><P><A><P><D><Q><P><Q><P><P><L><Q><R><G><T><R><L><R><L><R><Q><R><R><R><R><L><L><I><K><K><M><P><A><A><A><T><I><P><A><N><S><S><D><A><P><F><I><R><P><G><P><G><T><L><D><G><R><W><V><S><L><H><R><S><Q><Q><E><R><K><R><V><M><Q><E><A><C><A><K><Y><R><A><S><S><S><R><R><A><V><T><P><R><H><V><S><R><I><F><V><E><D><R><H><R><V><L><Y><C><E><V><P><K><A><G><C><S><N><W><K><R><V><L><M><V><L><A><G><L><A><S><S><T><A><D><I><Q><H><N><T><V><H><Y><G><S><A><L><K><R><L><D><T><F><D><R><Q><G><I><L><H><R><L><S><T><Y><T><K><M><L><F><V><R><E><P><F><E><R><L><V><S><A><F><R><D><K><F><E><H><P><N><S><Y><Y><H><P><V><F><G><K><A><I><L><A><R><Y><R><A><N><A><S><R><E><A><L><R><T><G><S><G><V><R><F><P><E><F><V><Q><Y><L><L><D><V><H><R><P><V><G><M><D><I><H><W><D><H><V><S><R><L><C><S><P><C><L><I><D><Y><D><F><V><G><K><F><E><S><M><E><D><D><A><N><F><F><L><S><L><I><R><A><P><R><N><L><T><F><P><R><F><K><D><R><H><S><Q><E><A><R><T><T><A><R><I><A><H><Q><Y><F><A><Q><L><S><A><L><Q><R><Q><R><T><Y><D><F><Y><Y><M><D><Y><L><M><F><N><Y><S><K><P><F><A><D><L><Y>
|
Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.<BOP>
|
Q9H2A9
|
Q9BSK2
|
S2533_HUMAN
|
Protein PNC1
|
Homo
|
<M><A><T><G><G><Q><Q><K><E><N><T><L><L><H><L><F><A><G><G><C><G><G><T><V><G><A><I><F><T><C><P><L><E><V><I><K><T><R><L><Q><S><S><R><L><A><L><R><T><V><Y><Y><P><Q><V><H><L><G><T><I><S><G><A><G><M><V><R><P><T><S><V><T><P><G><L><F><Q><V><L><K><S><I><L><E><K><E><G><P><K><S><L><F><R><G><L><G><P><N><L><V><G><V><A><P><S><R><A><V><Y><F><A><C><Y><S><K><A><K><E><Q><F><N><G><I><F><V><P><N><S><N><I><V><H><I><F><S><A><G><S><A><A><F><I><T><N><S><L><M><N><P><I><W><M><V><K><T><R><M><Q><L><E><Q><K><V><R><G><S><K><Q><M><N><T><L><Q><C><A><R><Y><V><Y><Q><T><E><G><I><R><G><F><Y><R><G><L><T><A><S><Y><A><G><I><S><E><T><I><I><C><F><A><I><Y><E><S><L><K><K><Y><L><K><E><A><P><L><A><S><S><A><N><G><T><E><K><N><S><T><S><F><F><G><L><M><A><A><A><A><L><S><K><G><C><A><S><C><I><A><Y><P><H><E><V><I><R><T><R><L><R><E><E><G><T><K><Y><K><S><F><V><Q><T><A><R><L><V><F><R><E><E><G><Y><L><A><F><Y><R><G><L><F><A><Q><L><I><R><Q><I><P><N><T><A><I><V><L><S><T><Y><E><L><I><V><Y><L><L><E><D><R><T><Q>
|
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria . Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism . Also transports guanine but not adenine (deoxy)nucleotides . Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) . Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration . Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production . Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation .<BOP>
|
Q9BSK2
|
Q8TC84
|
FANK1_HUMAN
|
Fibronectin type 3 and ankyrin repeat domains protein 1
|
Homo
|
<M><E><P><Q><K><I><M><P><P><S><K><P><H><P><P><V><V><G><K><V><T><H><H><S><I><E><L><Y><W><D><L><E><K><K><A><K><R><Q><G><P><Q><E><Q><W><F><R><F><S><I><E><E><E><D><P><K><M><H><T><Y><G><I><I><Y><T><G><Y><A><T><K><H><V><V><E><G><L><E><P><R><T><L><Y><R><F><R><L><K><V><T><S><P><S><G><E><C><E><Y><S><P><L><V><S><V><S><T><T><R><E><P><I><S><S><E><H><L><H><R><A><V><S><V><N><D><E><D><L><L><V><R><I><L><Q><G><G><R><V><K><V><D><V><P><N><K><F><G><F><T><A><L><M><V><A><A><Q><K><G><Y><T><R><L><V><K><I><L><V><S><N><G><T><D><V><N><L><K><N><G><S><G><K><D><S><L><M><L><A><C><Y><A><G><H><L><D><V><V><K><Y><L><R><R><H><G><A><S><W><Q><A><R><D><L><G><G><C><T><A><L><H><W><A><A><D><G><G><H><C><S><V><I><E><W><M><I><K><D><G><C><E><V><D><V><V><D><T><G><S><G><W><T><P><L><M><R><V><S><A><V><S><G><N><Q><R><V><A><S><L><L><I><D><A><G><A><N><V><N><V><K><D><R><N><G><K><T><P><L><M><V><A><V><L><N><N><H><E><E><L><V><Q><L><L><L><D><K><G><A><D><A><S><V><K><N><E><F><G><K><G><V><L><E><M><A><R><V><F><D><R><Q><S><V><V><S><L><L><E><E><R><K><K><K><Q><R><P><K><K><S><C><V><C>
|
Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.<BOP>
|
Q8TC84
|
P40394
|
ADH7_HUMAN
|
Retinol dehydrogenase
|
Homo
|
<M><F><A><E><I><Q><I><Q><D><K><D><R><M><G><T><A><G><K><V><I><K><C><K><A><A><V><L><W><E><Q><K><Q><P><F><S><I><E><E><I><E><V><A><P><P><K><T><K><E><V><R><I><K><I><L><A><T><G><I><C><R><T><D><D><H><V><I><K><G><T><M><V><S><K><F><P><V><I><V><G><H><E><A><T><G><I><V><E><S><I><G><E><G><V><T><T><V><K><P><G><D><K><V><I><P><L><F><L><P><Q><C><R><E><C><N><A><C><R><N><P><D><G><N><L><C><I><R><S><D><I><T><G><R><G><V><L><A><D><G><T><T><R><F><T><C><K><G><K><P><V><H><H><F><M><N><T><S><T><F><T><E><Y><T><V><V><D><E><S><S><V><A><K><I><D><D><A><A><P><P><E><K><V><C><L><I><G><C><G><F><S><T><G><Y><G><A><A><V><K><T><G><K><V><K><P><G><S><T><C><V><V><F><G><L><G><G><V><G><L><S><V><I><M><G><C><K><S><A><G><A><S><R><I><I><G><I><D><L><N><K><D><K><F><E><K><A><M><A><V><G><A><T><E><C><I><S><P><K><D><S><T><K><P><I><S><E><V><L><S><E><M><T><G><N><N><V><G><Y><T><F><E><V><I><G><H><L><E><T><M><I><D><A><L><A><S><C><H><M><N><Y><G><T><S><V><V><V><G><V><P><P><S><A><K><M><L><T><Y><D><P><M><L><L><F><T><G><R><T><W><K><G><C><V><F><G><G><L><K><S><R><D><D><V><P><K><L><V><T><E><F><L><A><K><K><F><D><L><D><Q><L><I><T><H><V><L><P><F><K><K><I><S><E><G><F><E><L><L><N><S><G><Q><S><I><R><T><V><L><T><F>
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Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives . Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid . In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives . Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal . Catalyzes in the oxidative direction with higher efficiency . Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation .<BOP>
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P40394
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Q96FI4
|
NEIL1_HUMAN
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Nei-like protein 1
|
Homo
|
<M><P><E><G><P><E><L><H><L><A><S><Q><F><V><N><E><A><C><R><A><L><V><F><G><G><C><V><E><K><S><S><V><S><R><N><P><E><V><P><F><E><S><S><A><Y><R><I><S><A><S><A><R><G><K><E><L><R><L><I><L><S><P><L><P><G><A><Q><P><Q><Q><E><P><L><A><L><V><F><R><F><G><M><S><G><S><F><Q><L><V><P><R><E><E><L><P><R><H><A><H><L><R><F><Y><T><A><P><P><G><P><R><L><A><L><C><F><V><D><I><R><R><F><G><R><W><D><L><G><G><K><W><Q><P><G><R><G><P><C><V><L><Q><E><Y><Q><Q><F><R><E><N><V><L><R><N><L><A><D><K><A><F><D><R><P><I><C><E><A><L><L><D><Q><R><F><F><N><G><I><G><N><Y><L><R><A><E><I><L><Y><R><L><K><I><P><P><F><E><K><A><R><S><V><L><E><A><L><Q><Q><H><R><P><S><P><E><L><T><L><S><Q><K><I><R><T><K><L><Q><N><P><D><L><L><E><L><C><H><S><V><P><K><E><V><V><Q><L><G><G><K><G><Y><G><S><E><S><G><E><E><D><F><A><A><F><R><A><W><L><R><C><Y><G><M><P><G><M><S><S><L><Q><D><R><H><G><R><T><I><W><F><Q><G><D><P><G><P><L><A><P><K><G><R><K><S><R><K><K><K><S><K><A><T><Q><L><S><P><E><D><R><V><E><D><A><L><P><P><S><K><A><P><S><R><T><R><R><A><K><R><D><L><P><K><R><T><A><T><Q><R><P><E><G><T><S><L><Q><Q><D><P><E><A><P><T><V><P><K><K><G><R><R><K><G><R><Q><A><A><S><G><H><C><R><P><R><K><V><K><A><D><I><P><S><L><E><P><E><G><T><S><A><S>
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Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.<BOP>
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Q96FI4
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Q6NXT4
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ZNT6_HUMAN
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Solute carrier family 30 member 6
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Homo
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<M><G><T><I><H><L><F><R><K><P><Q><R><S><F><F><G><K><L><L><R><E><F><R><L><V><A><A><D><R><R><S><W><K><I><L><L><F><G><V><I><N><L><I><C><T><G><F><L><L><M><W><C><S><S><T><N><S><I><A><L><T><A><Y><T><Y><L><T><I><F><D><L><F><S><L><M><T><C><L><I><S><Y><W><V><T><L><R><K><P><S><P><V><Y><S><F><G><F><E><R><L><E><V><L><A><V><F><A><S><T><V><L><A><Q><L><G><A><L><F><I><L><K><E><S><A><E><R><F><L><E><Q><P><E><I><H><T><G><R><L><L><V><G><T><F><V><A><L><C><F><N><L><F><T><M><L><S><I><R><N><K><P><F><A><Y><V><S><E><A><A><S><T><S><W><L><Q><E><H><V><A><D><L><S><R><S><L><C><G><I><I><P><G><L><S><S><I><F><L><P><R><M><N><P><F><V><L><I><D><L><A><G><A><F><A><L><C><I><T><Y><M><L><I><E><I><N><N><Y><F><A><V><D><T><A><S><A><I><A><I><A><L><M><T><F><G><T><M><Y><P><M><S><V><Y><S><G><K><V><L><L><Q><T><T><P><P><H><V><I><G><Q><L><D><K><L><I><R><E><V><S><T><L><D><G><V><L><E><V><R><N><E><H><F><W><T><L><G><F><G><S><L><A><G><S><V><H><V><R><I><R><R><D><A><N><E><Q><M><V><L><A><H><V><T><N><R><L><Y><T><L><V><S><T><L><T><V><Q><I><F><K><D><D><W><I><R><P><A><L><L><S><G><P><V><A><A><N><V><L><N><F><S><D><H><H><V><I><P><M><P><L><L><K><G><T><D><D><L><N><P><V><T><S><T><P><A><K><P><S><S><P><P><P><E><F><S><F><N><T><P><G><K><N><V><N><P><V><I><L><L><N><T><Q><T><R><P><Y><G><F><G><L><N><H><G><H><T><P><Y><S><S><M><L><N><Q><G><L><G><V><P><G><I><G><A><T><Q><G><L><R><T><G><F><T><N><I><P><S><R><Y><G><T><N><N><R><I><G><Q><P><R><P>
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Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.<BOP>
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Q6NXT4
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Q76KX8
|
ZN534_HUMAN
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KRAB domain only protein 3
|
Homo
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<M><A><L><T><Q><G><Q><L><S><F><S><D><V><A><I><E><F><S><Q><E><E><W><K><C><L><D><P><G><Q><K><A><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><G><E><D><N><V><R><P><E><A><C><I><C><S><G><I><C><L><P><D><L><S><V><T><S><M><L><E><Q><K><R><D><P><W><T><L><Q><S><E><V><K><I><I><N><N><P><D><G><R><E><C><I><K><G><V><N><T><E><K><S><S><K><L><G><S><S><A><G><N><K><S><L><K><N><Q><H><G><L><T><L><Q><L><H><L><T><E><W><Q><P><F><Q><A><V><R><N><I><Y><G><C><K><H><V><E><K><S><I><S><D><N><S><S><V><S><P><V><Q><I><S><F><F><S><V><K><T><H><I><F><N><N><Y><R><N><D><F><L><F><S><T><L><L><P><Q><E><Q><K><V><H><I><R><E><K><P><Y><G><C><N><E><H><G><K><V><F><R><V><S><S><S><L><T><N><R><Q><V><I><H><I><A><D><K><T><Y><K><C><S><D><C><G><E><I><F><S><S><N><S><N><F><A><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><Y><N><E><C><G><K><V><F><N><Q><N><S><H><L><A><Q><H><Q><K><I><H><T><G><Q><K><P><Y><N><N><K><E><C><G><K><V><F><S><H><H><A><Y><L><A><Q><H><R><K><I><H><T><G><E><K><P><Y><K><C><S><E><C><G><K><A><F><S><V><C><S><S><L><T><A><H><L><V><I><H><T><G><E><K><P><Y><D><C><K><E><C><G><K><V><F><R><H><K><S><S><L><T><T><H><Q><T><V><H><T><G><E><R><P><Y><K><C><N><E><C><G><K><G><F><S><R><I><A><F><L><A><R><H><R><K><V><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><I><G><N><S><R><L><A><R><H><R><K><I><H><T><G><G><R><R><Y><K><C><N><E><C><G><K><A><F><R><T><C><S><D><L><T><A><H><L><L><I><H><T><G><E><K><P><Y><E><C><I><D><C><G><K><V><F><R><H><K><S><S><L><T><Y><H><C><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><S><Q><N><S><N><L><Q><R><H><R><K><I><H><T><G><E><K><L><Y><K><C><N><E><C><G><K><V><F><R><Q><N><S><H><L><A><Q><H><R><D><I><H><T><G><E><K><P><Y><S><C><N><E><C><G><K><V><F><R><R><N><S><H><L><V><R><H><R><N><V><H><T><G><E><K><P><Y><S><C><N><E><C><G><K><V><F><S><R><N><S><H><L><A><R><H><R><N><I><H><T><G><E><K><P><H><S><C><N><E><C><G><K><V><F><S><R><N><S><H><L><A><R><H><R><K><I><H><T><G><E><K><L><Y><K><C><N><E><C><S><K><V><F><S><R><N><S><R><L><A><Q><H><R><N><I><H><T><G><V><K><P><Y><S><C><N><E><C><G><K><V><F><S><K><N><S><I><L><V><Q><H><C><S><I><H><T><R><E><K><P>
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May be involved in transcriptional regulation.<BOP>
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Q76KX8
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Q96LK0
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CEP19_HUMAN
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Centrosomal protein of 19 kDa
|
Homo
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<M><M><C><T><A><K><K><C><G><I><R><F><Q><P><P><A><I><I><L><I><Y><E><S><E><I><K><G><K><I><R><Q><R><I><M><P><V><R><N><F><S><K><F><S><D><C><T><R><A><A><E><Q><L><K><N><N><P><R><H><K><S><Y><L><E><Q><V><S><L><R><Q><L><E><K><L><F><S><F><L><R><G><Y><L><S><G><Q><S><L><A><E><T><M><E><Q><I><Q><R><E><T><T><I><D><P><E><E><D><L><N><K><L><D><D><K><E><L><A><K><R><K><S><I><M><D><E><L><F><E><K><N><Q><K><K><K><D><D><P><N><F><V><Y><D><I><E><V><E><F><P><Q><D><D><Q><L><Q><S><C><G><W><D><T><E><S><A><D><E><F>
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Required for ciliation . Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia . Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes .<BOP>
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Q96LK0
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Q33E94
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RFX4_HUMAN
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Testis development protein NYD-SP10
|
Homo
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<M><H><C><G><L><L><E><E><P><D><M><D><S><T><E><S><W><I><E><R><C><L><N><E><S><E><N><K><R><Y><S><S><H><T><S><L><G><N><V><S><N><D><E><N><E><E><K><E><N><N><R><A><S><K><P><H><S><T><P><A><T><L><Q><W><L><E><E><N><Y><E><I><A><E><G><V><C><I><P><R><S><A><L><Y><M><H><Y><L><D><F><C><E><K><N><D><T><Q><P><V><N><A><A><S><F><G><K><I><I><R><Q><Q><F><P><Q><L><T><T><R><R><L><G><T><R><G><Q><S><K><Y><H><Y><Y><G><I><A><V><K><E><S><S><Q><Y><Y><D><V><M><Y><S><K><K><G><A><A><W><V><S><E><T><G><K><K><E><V><S><K><Q><T><V><A><Y><S><P><R><S><K><L><G><T><L><L><P><E><F><P><N><V><K><D><L><N><L><P><A><S><L><P><E><E><K><V><S><T><F><I><M><M><Y><R><T><H><C><Q><R><I><L><D><T><V><I><R><A><N><F><D><E><V><Q><S><F><L><L><H><F><W><Q><G><M><P><P><H><M><L><P><V><L><G><S><S><T><V><V><N><I><V><G><V><C><D><S><I><L><Y><K><A><I><S><G><V><L><M><P><T><V><L><Q><A><L><P><D><S><L><T><Q><V><I><R><K><F><A><K><Q><L><D><E><W><L><K><V><A><L><H><D><L><P><E><N><L><R><N><I><K><F><E><L><S><R><R><F><S><Q><I><L><R><R><Q><T><S><L><N><H><L><C><Q><A><S><R><T><V><I><H><S><A><D><I><T><F><Q><M><L><E><D><W><R><N><V><D><L><N><S><I><T><K><Q><T><L><Y><T><M><E><D><S><R><D><E><H><R><K><L><I><T><Q><L><Y><Q><E><F><D><H><L><L><E><E><Q><S><P><I><E><S><Y><I><E><W><L><D><T><M><V><D><R><C><V><V><K><V><A><A><K><R><Q><G><S><L><K><K><V><A><Q><Q><F><L><L><M><W><S><C><F><G><T><R><V><I><R><D><M><T><L><H><S><A><P><S><F><G><S><F><H><L><I><H><L><M><F><D><D><Y><V><L><Y><L><L><E><S><L><H><C><Q><E><R><A><N><E><L><M><R><A><M><K><G><E><G><S><T><A><E><V><R><E><E><I><I><L><T><E><A><A><A><P><T><P><S><P><V><P><S><F><S><P><A><K><S><A><T><S><V><E><V><P><P><P><S><S><P><V><S><N><P><S><P><E><Y><T><G><L><S><T><T><G><A><M><Q><S><Y><T><W><S><L><T><Y><T><V><T><T><A><A><G><S><P><A><E><N><S><Q><Q><L><P><C><M><R><N><T><H><V><P><S><S><S><V><T><H><R><I><P><V><Y><P><H><R><E><E><H><G><Y><T><G><S><Y><N><Y><G><S><Y><G><N><Q><H><P><H><P><M><Q><S><Q><Y><P><A><L><P><H><D><T><A><I><S><G><P><L><H><Y><A><P><Y><H><R><S><S><A><Q><Y><P><F><N><S><P><T><S><R><M><E><P><C><L><M><S><S><T><P><R><L><H><P><T><P><V><T><P><R><W><P><E><V><P><S><A><N><T><C><Y><T><S><P><S><V><H><S><A><R><Y><G><N><S><S><D><M><Y><T><P><L><T><T><R><R><N><S><E><Y><E><H><M><Q><H><F><P><G><F><A><Y><I><N><G><E><A><S><T><G><W><A><K>
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Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development.<BOP>
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Q33E94
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Q9NRM6
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I17RB_HUMAN
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Interleukin-17B receptor
|
Homo
|
<M><S><L><V><L><L><S><L><A><A><L><C><R><S><A><V><P><R><E><P><T><V><Q><C><G><S><E><T><G><P><S><P><E><W><M><L><Q><H><D><L><I><P><G><D><L><R><D><L><R><V><E><P><V><T><T><S><V><A><T><G><D><Y><S><I><L><M><N><V><S><W><V><L><R><A><D><A><S><I><R><L><L><K><A><T><K><I><C><V><T><G><K><S><N><F><Q><S><Y><S><C><V><R><C><N><Y><T><E><A><F><Q><T><Q><T><R><P><S><G><G><K><W><T><F><S><Y><I><G><F><P><V><E><L><N><T><V><Y><F><I><G><A><H><N><I><P><N><A><N><M><N><E><D><G><P><S><M><S><V><N><F><T><S><P><G><C><L><D><H><I><M><K><Y><K><K><K><C><V><K><A><G><S><L><W><D><P><N><I><T><A><C><K><K><N><E><E><T><V><E><V><N><F><T><T><T><P><L><G><N><R><Y><M><A><L><I><Q><H><S><T><I><I><G><F><S><Q><V><F><E><P><H><Q><K><K><Q><T><R><A><S><V><V><I><P><V><T><G><D><S><E><G><A><T><V><Q><L><T><P><Y><F><P><T><C><G><S><D><C><I><R><H><K><G><T><V><V><L><C><P><Q><T><G><V><P><F><P><L><D><N><N><K><S><K><P><G><G><W><L><P><L><L><L><L><S><L><L><V><A><T><W><V><L><V><A><G><I><Y><L><M><W><R><H><E><R><I><K><K><T><S><F><S><T><T><T><L><L><P><P><I><K><V><L><V><V><Y><P><S><E><I><C><F><H><H><T><I><C><Y><F><T><E><F><L><Q><N><H><C><R><S><E><V><I><L><E><K><W><Q><K><K><K><I><A><E><M><G><P><V><Q><W><L><A><T><Q><K><K><A><A><D><K><V><V><F><L><L><S><N><D><V><N><S><V><C><D><G><T><C><G><K><S><E><G><S><P><S><E><N><S><Q><D><L><F><P><L><A><F><N><L><F><C><S><D><L><R><S><Q><I><H><L><H><K><Y><V><V><V><Y><F><R><E><I><D><T><K><D><D><Y><N><A><L><S><V><C><P><K><Y><H><L><M><K><D><A><T><A><F><C><A><E><L><L><H><V><K><Q><Q><V><S><A><G><K><R><S><Q><A><C><H><D><G><C><C><S><L>
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Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.<BOP>
|
Q9NRM6
|
Q96BD8
|
SKA1_HUMAN
|
Spindle and kinetochore-associated protein 1
|
Homo
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<M><A><S><S><D><L><E><Q><L><C><S><H><V><N><E><K><I><G><N><I><K><K><T><L><S><L><R><N><C><G><Q><E><P><T><L><K><T><V><L><N><K><I><G><D><E><I><I><V><I><N><E><L><L><N><K><L><E><L><E><I><Q><Y><Q><E><Q><T><N><N><S><L><K><E><L><C><E><S><L><E><E><D><Y><K><D><I><E><H><L><K><E><N><V><P><S><H><L><P><Q><V><T><V><T><Q><S><C><V><K><G><S><D><L><D><P><E><E><P><I><K><V><E><E><P><E><P><V><K><K><P><P><K><E><Q><R><S><I><K><E><M><P><F><I><T><C><D><E><F><N><G><V><P><S><Y><M><K><S><R><L><T><Y><N><Q><I><N><D><V><I><K><E><I><N><K><A><V><I><S><K><Y><K><I><L><H><Q><P><K><K><S><M><N><S><V><T><R><N><L><Y><H><R><F><I><D><E><E><T><K><D><T><K><G><R><Y><F><I><V><E><A><D><I><K><E><F><T><T><L><K><A><D><K><K><F><H><V><L><L><N><I><L><R><H><C><R><R><L><S><E><V><R><G><G><G><L><T><R><Y><V><I><T>
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Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation . Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint . The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies . The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner . Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules . In the complex, it mediates the interaction with microtubules .<BOP>
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Q96BD8
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Q14749
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GNMT_HUMAN
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Glycine N-methyltransferase
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Homo
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<M><V><D><S><V><Y><R><T><R><S><L><G><V><A><A><E><G><L><P><D><Q><Y><A><D><G><E><A><A><R><V><W><Q><L><Y><I><G><D><T><R><S><R><T><A><E><Y><K><A><W><L><L><G><L><L><R><Q><H><G><C><Q><R><V><L><D><V><A><C><G><T><G><V><D><S><I><M><L><V><E><E><G><F><S><V><T><S><V><D><A><S><D><K><M><L><K><Y><A><L><K><E><R><W><N><R><R><H><E><P><A><F><D><K><W><V><I><E><E><A><N><W><M><T><L><D><K><D><V><P><Q><S><A><E><G><G><F><D><A><V><I><C><L><G><N><S><F><A><H><L><P><D><C><K><G><D><Q><S><E><H><R><L><A><L><K><N><I><A><S><M><V><R><A><G><G><L><L><V><I><D><H><R><N><Y><D><H><I><L><S><T><G><C><A><P><P><G><K><N><I><Y><Y><K><S><D><L><T><K><D><V><T><T><S><V><L><I><V><N><N><K><A><H><M><V><T><L><D><Y><T><V><Q><V><P><G><A><G><Q><D><G><S><P><G><L><S><K><F><R><L><S><Y><Y><P><H><C><L><A><S><F><T><E><L><L><Q><A><A><F><G><G><K><C><Q><H><S><V><L><G><D><F><K><P><Y><K><P><G><Q><T><Y><I><P><C><Y><F><I><H><V><L><K><R><T><D>
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Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine.<BOP>
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Q14749
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Q9BYQ5
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KRA46_HUMAN
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Ultrahigh sulfur keratin-associated protein 4.15
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Homo
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<M><V><S><S><C><C><G><S><V><C><S><D><Q><G><C><G><L><E><T><C><C><R><P><S><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><C><P><S><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><S><I><S><S><C><C><R><P><S><C><C><V><S><R><C><C><R><S><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><C><I><S><S><C><C><R><P><S><C><C><E><S><S><C><C><R><P><C><C><C><R><P><C><C><C><L><R><P><V><C><G><R><V><S><C><H><T><T><C><Y><R><P><T><C><V><I><S><T><C><P><R><P><L><C><C><A><S><S><C><C>
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In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
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Q9BYQ5
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Q96C23
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GALM_HUMAN
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Aldose 1-epimerase
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Homo
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<M><A><S><V><T><R><A><V><F><G><E><L><P><S><G><G><G><T><V><E><K><F><Q><L><Q><S><D><L><L><R><V><D><I><I><S><W><G><C><T><I><T><A><L><E><V><K><D><R><Q><G><R><A><S><D><V><V><L><G><F><A><E><L><E><G><Y><L><Q><K><Q><P><Y><F><G><A><V><I><G><R><V><A><N><R><I><A><K><G><T><F><K><V><D><G><K><E><Y><H><L><A><I><N><K><E><P><N><S><L><H><G><G><V><R><G><F><D><K><V><L><W><T><P><R><V><L><S><N><G><V><Q><F><S><R><I><S><P><D><G><E><E><G><Y><P><G><E><L><K><V><W><V><T><Y><T><L><D><G><G><E><L><I><V><N><Y><R><A><Q><A><S><Q><A><T><P><V><N><L><T><N><H><S><Y><F><N><L><A><G><Q><A><S><P><N><I><N><D><H><E><V><T><I><E><A><D><T><Y><L><P><V><D><E><T><L><I><P><T><G><E><V><A><P><V><Q><G><T><A><F><D><L><R><K><P><V><E><L><G><K><H><L><Q><D><F><H><L><N><G><F><D><H><N><F><C><L><K><G><S><K><E><K><H><F><C><A><R><V><H><H><A><A><S><G><R><V><L><E><V><Y><T><T><Q><P><G><V><Q><F><Y><T><G><N><F><L><D><G><T><L><K><G><K><N><G><A><V><Y><P><K><H><S><G><F><C><L><E><T><Q><N><W><P><D><A><V><N><Q><P><R><F><P><P><V><L><L><R><P><G><E><E><Y><D><H><T><T><W><F><K><F><S><V><A>
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Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism . Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase) . Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1 . Also active on D-glucose although shows a preference for galactose over glucose .<BOP>
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Q96C23
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Q8NGA4
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G32P1_HUMAN
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G-protein coupled receptor GPCR39
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Homo
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<M><N><G><V><S><E><G><T><R><G><C><S><D><R><Q><P><G><A><L><T><Q><G><H><S><C><S><R><K><M><N><A><S><R><C><L><S><E><E><V><G><S><L><R><P><L><T><M><A><V><L><S><A><S><F><V><V><G><V><L><G><N><G><L><V><P><W><V><T><V><F><R><M><A><R><T><V><S><T><V><C><F><F><H><L><A><L><A><D><F><M><L><S><L><S><L><P><I><L><V><Y><Y><I><V><S><R><Q><W><L><L><G><E><W><A><C><K><L><Y><T><G><F><V><F><L><T><F><S><T><S><N><C><L><L><V><L><I><S><V><D><R><C><I><S><V><L><Y><P><V><W><A><L><N><H><R><T><E><Q><R><A><S><W><L><A><F><G><V><W><L><L><A><A><A><L><C><S><A><H><L><K><F><R><T><T><R><K><W><N><G><C><M><Q><C><Y><L><Q><F><N><L><E><N><E><T><A><Q><M><W><T><Q><E><V><F><G><R><Q><M><A><V><I><M><A><H><F><L><L><G><F><L><G><P><L><A><I><I><G><T><C><A><H><L><I><R><A><K><L><L><R><E><G><W><V><H><A><N><R><P><K><R><L><L><L><V><L><V><S><A><L><S><A><G><S><H><L><T>
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Orphan receptor.<BOP>
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Q8NGA4
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P25106
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ACKR3_HUMAN
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G-protein coupled receptor RDC1 homolog
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Homo
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<M><D><L><H><L><F><D><Y><S><E><P><G><N><F><S><D><I><S><W><P><C><N><S><S><D><C><I><V><V><D><T><V><M><C><P><N><M><P><N><K><S><V><L><L><Y><T><L><S><F><I><Y><I><F><I><F><V><I><G><M><I><A><N><S><V><V><V><W><V><N><I><Q><A><K><T><T><G><Y><D><T><H><C><Y><I><L><N><L><A><I><A><D><L><W><V><V><L><T><I><P><V><W><V><V><S><L><V><Q><H><N><Q><W><P><M><G><E><L><T><C><K><V><T><H><L><I><F><S><I><N><L><F><G><S><I><F><F><L><T><C><M><S><V><D><R><Y><L><S><I><T><Y><F><T><N><T><P><S><S><R><K><K><M><V><R><R><V><V><C><I><L><V><W><L><L><A><F><C><V><S><L><P><D><T><Y><Y><L><K><T><V><T><S><A><S><N><N><E><T><Y><C><R><S><F><Y><P><E><H><S><I><K><E><W><L><I><G><M><E><L><V><S><V><V><L><G><F><A><V><P><F><S><I><I><A><V><F><Y><F><L><L><A><R><A><I><S><A><S><S><D><Q><E><K><H><S><S><R><K><I><I><F><S><Y><V><V><V><F><L><V><C><W><L><P><Y><H><V><A><V><L><L><D><I><F><S><I><L><H><Y><I><P><F><T><C><R><L><E><H><A><L><F><T><A><L><H><V><T><Q><C><L><S><L><V><H><C><C><V><N><P><V><L><Y><S><F><I><N><R><N><Y><R><Y><E><L><M><K><A><F><I><F><K><Y><S><A><K><T><G><L><T><K><L><I><D><A><S><R><V><S><E><T><E><Y><S><A><L><E><Q><S><T><K>
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(Microbial infection) Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.<BOP>
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P25106
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Q9BV20
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MTNA_HUMAN
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Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein
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Homo
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<M><T><L><E><A><I><R><Y><S><R><G><S><L><Q><I><L><D><Q><L><L><L><P><K><Q><S><R><Y><E><A><V><G><S><V><H><Q><A><W><E><A><I><R><A><M><K><V><R><G><A><P><A><I><A><L><V><G><C><L><S><L><A><V><E><L><Q><A><G><A><G><G><P><G><L><A><A><L><V><A><F><V><R><D><K><L><S><F><L><V><T><A><R><P><T><A><V><N><M><A><R><A><A><R><D><L><A><D><V><A><A><R><E><A><E><R><E><G><A><T><E><E><A><V><R><E><R><V><I><C><C><T><E><D><M><L><E><K><D><L><R><D><N><R><S><I><G><D><L><G><A><R><H><L><L><E><R><V><A><P><S><G><G><K><V><T><V><L><T><H><C><N><T><G><A><L><A><T><A><G><Y><G><T><A><L><G><V><I><R><S><L><H><S><L><G><R><L><E><H><A><F><C><T><E><T><R><P><Y><N><Q><G><A><R><L><T><A><F><E><L><V><Y><E><Q><I><P><A><T><L><I><T><D><S><M><V><A><A><A><M><A><H><R><G><V><S><A><V><V><V><G><A><D><R><V><V><A><N><G><D><T><A><N><K><V><G><T><Y><Q><L><A><I><V><A><K><H><H><G><I><P><F><Y><V><A><A><P><S><S><S><C><D><L><R><L><E><T><G><K><E><I><I><I><E><E><R><P><G><Q><E><L><T><D><V><N><G><V><R><I><A><A><P><G><I><G><V><W><N><P><A><F><D><V><T><P><H><D><L><I><T><G><G><I><I><T><E><L><G><V><F><A><P><E><E><L><R><T><A><L><T><T><T><I><S><S><R><D><G><T><L><D><G><P><Q><M>
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Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<BOP>
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Q9BV20
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Q16619
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CTF1_HUMAN
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Cardiotrophin-1
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Homo
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<M><S><R><R><E><G><S><L><E><D><P><Q><T><D><S><S><V><S><L><L><P><H><L><E><A><K><I><R><Q><T><H><S><L><A><H><L><L><T><K><Y><A><E><Q><L><L><Q><E><Y><V><Q><L><Q><G><D><P><F><G><L><P><S><F><S><P><P><R><L><P><V><A><G><L><S><A><P><A><P><S><H><A><G><L><P><V><H><E><R><L><R><L><D><A><A><A><L><A><A><L><P><P><L><L><D><A><V><C><R><R><Q><A><E><L><N><P><R><A><P><R><L><L><R><R><L><E><D><A><A><R><Q><A><R><A><L><G><A><A><V><E><A><L><L><A><A><L><G><A><A><N><R><G><P><R><A><E><P><P><A><A><T><A><S><A><A><S><A><T><G><V><F><P><A><K><V><L><G><L><R><V><C><G><L><Y><R><E><W><L><S><R><T><E><G><D><L><G><Q><L><L><P><G><G><S><A>
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Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.<BOP>
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Q16619
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Q53GS7
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GLE1_HUMAN
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Nucleoporin GLE1
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Homo
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<M><P><S><E><G><R><C><W><E><T><L><K><A><L><R><S><S><D><K><G><R><L><C><Y><Y><R><D><W><L><L><R><R><E><D><V><L><E><E><C><M><S><L><P><K><L><S><S><Y><S><G><W><V><V><E><H><V><L><P><H><M><Q><E><N><Q><P><L><S><E><T><S><P><S><S><T><S><A><S><A><L><D><Q><P><S><F><V><P><K><S><P><D><A><S><S><A><F><S><P><A><S><P><A><T><P><N><G><T><K><G><K><D><E><S><Q><H><T><E><S><M><V><L><Q><S><S><R><G><I><K><V><E><G><C><V><R><M><Y><E><L><V><H><R><M><K><G><T><E><G><L><R><L><W><Q><E><E><Q><E><R><K><V><Q><A><L><S><E><M><A><S><E><Q><L><K><R><F><D><E><W><K><E><L><K><Q><H><K><E><F><Q><D><L><R><E><V><M><E><K><S><S><R><E><A><L><G><H><Q><E><K><L><K><A><E><H><R><H><R><A><K><I><L><N><L><K><L><R><E><A><E><Q><Q><R><V><K><Q><A><E><Q><E><R><L><R><K><E><E><G><Q><I><R><L><R><A><L><Y><A><L><Q><E><E><M><L><Q><L><S><Q><Q><L><D><A><S><E><Q><H><K><A><L><L><K><V><D><L><A><A><F><Q><T><R><G><N><Q><L><C><S><L><I><S><G><I><I><R><A><S><S><E><S><S><Y><P><T><A><E><S><Q><A><E><A><E><R><A><L><R><E><M><R><D><L><L><M><N><L><G><Q><E><I><T><R><A><C><E><D><K><R><R><Q><D><E><E><E><A><Q><V><K><L><Q><E><A><Q><M><Q><Q><G><P><E><A><H><K><E><P><P><A><P><S><Q><G><P><G><G><K><Q><N><E><D><L><Q><V><K><V><Q><D><I><T><M><Q><W><Y><Q><Q><L><Q><D><A><S><M><Q><C><V><L><T><F><E><G><L><T><N><S><K><D><S><Q><A><K><K><I><K><M><D><L><Q><K><A><A><T><I><P><V><S><Q><I><S><T><I><A><G><S><K><L><K><E><I><F><D><K><I><H><S><L><L><S><G><K><P><V><Q><S><G><G><R><S><V><S><V><T><L><N><P><Q><G><L><D><F><V><Q><Y><K><L><A><E><K><F><V><K><Q><G><E><E><E><V><A><S><H><H><E><A><A><F><P><I><A><V><V><A><S><G><I><W><E><L><H><P><R><V><G><D><L><I><L><A><H><L><H><K><K><C><P><Y><S><V><P><F><Y><P><T><F><K><E><G><M><A><L><E><D><Y><Q><R><M><L><G><Y><Q><V><K><D><S><K><V><E><Q><Q><D><N><F><L><K><R><M><S><G><M><I><R><L><Y><A><A><I><I><Q><L><R><W><P><Y><G><N><R><Q><E><I><H><P><H><G><L><N><H><G><W><R><W><L><A><Q><I><L><N><M><E><P><L><S><D><V><T><A><T><L><L><F><D><F><L><E><V><C><G><N><A><L><M><K><Q><Y><Q><V><Q><F><W><K><M><L><I><L><I><K><E><D><Y><F><P><R><I><E><A><I><T><S><S><G><Q><M><G><S><F><I><R><L><K><Q><F><L><E><K><C><L><Q><H><K><D><I><P><V><P><K><G><F><L><T><S><S><F><W><R><S>
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Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).<BOP>
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Q53GS7
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Q02386
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ZNF45_HUMAN
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Zinc finger protein KOX5
|
Homo
|
<M><T><K><S><K><E><A><V><T><F><K><D><V><A><V><V><F><S><E><E><E><L><Q><L><L><D><L><A><Q><R><K><L><Y><R><D><V><M><L><E><N><F><R><N><V><V><S><V><G><H><Q><S><T><P><D><G><L><P><Q><L><E><R><E><E><K><L><W><M><M><K><M><A><T><Q><R><D><N><S><S><G><A><K><N><L><K><E><M><E><T><L><Q><E><V><G><L><R><Y><L><P><H><E><E><L><F><C><S><Q><I><W><Q><Q><I><T><R><E><L><I><K><Y><Q><D><S><V><V><N><I><Q><R><T><G><C><Q><L><E><K><R><D><D><L><H><Y><K><D><E><G><F><S><N><Q><S><S><H><L><Q><V><H><R><V><H><T><G><E><K><P><Y><K><G><E><H><C><V><K><S><F><S><W><S><S><H><L><Q><I><N><Q><R><A><H><A><G><E><K><P><Y><K><C><E><K><C><D><N><A><F><R><R><F><S><S><L><Q><A><H><Q><R><V><H><S><R><A><K><S><Y><T><N><D><A><S><Y><R><S><F><S><Q><R><S><H><L><P><H><H><Q><R><V><P><T><G><E><N><P><Y><K><Y><E><E><C><G><R><N><V><G><K><S><S><H><C><Q><A><P><L><I><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><V><G><F><S><Q><R><S><Y><L><Q><V><H><L><K><V><H><T><G><K><K><P><Y><K><C><E><E><C><G><K><S><F><S><W><R><S><R><L><Q><A><H><E><R><I><H><T><G><E><K><P><Y><K><C><N><A><C><G><K><S><F><S><Y><S><S><H><L><N><I><H><C><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><G><F><S><V><G><S><H><L><Q><A><H><Q><I><S><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><G><F><C><R><A><S><N><L><L><D><H><Q><R><G><H><T><G><E><K><P><Y><Q><C><D><A><C><G><K><G><F><S><R><S><S><D><F><N><I><H><F><R><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><G><F><S><Q><A><S><N><L><L><A><H><Q><R><G><H><T><G><E><K><P><Y><K><C><G><T><C><G><K><G><F><S><R><S><S><D><L><N><V><H><C><R><I><H><T><G><E><K><P><Y><K><C><E><R><C><G><K><A><F><S><Q><F><S><S><L><Q><V><H><Q><R><V><H><T><G><E><K><P><Y><Q><C><A><E><C><G><K><G><F><S><V><G><S><Q><L><Q><A><H><Q><R><C><H><T><G><E><K><P><Y><Q><C><E><E><C><G><K><G><F><C><R><A><S><N><F><L><A><H><R><G><V><H><T><G><E><K><P><Y><R><C><D><V><C><G><K><R><F><R><Q><R><S><Y><L><Q><A><H><Q><R><V><H><T><G><E><R><P><Y><K><C><E><E><C><G><K><V><F><S><W><S><S><Y><L><Q><A><H><Q><R><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><G><F><S><W><S><S><S><L><I><I><H><Q><R><V><H><A><D><D><E><G><D><K><D><F><P><S><S><E><D><S><H><R><K><T><R>
|
May be involved in transcriptional regulation.<BOP>
|
Q02386
|
Q8ND76
|
CCNY_HUMAN
|
cyclin-X
|
Homo
|
<M><G><N><T><T><S><C><C><V><S><S><S><P><K><L><R><R><N><A><H><S><R><L><E><S><Y><R><P><D><T><D><L><S><R><E><D><T><G><C><N><L><Q><H><I><S><D><R><E><N><I><D><D><L><N><M><E><F><N><P><S><D><H><P><R><A><S><T><I><F><L><S><K><S><Q><T><D><V><R><E><K><R><K><S><L><F><I><N><H><H><P><P><G><Q><I><A><R><K><Y><S><S><C><S><T><I><F><L><D><D><S><T><V><S><Q><P><N><L><K><Y><T><I><K><C><V><A><L><A><I><Y><Y><H><I><K><N><R><D><P><D><G><R><M><L><L><D><I><F><D><E><N><L><H><P><L><S><K><S><E><V><P><P><D><Y><D><K><H><N><P><E><Q><K><Q><I><Y><R><F><V><R><T><L><F><S><A><A><Q><L><T><A><E><C><A><I><V><T><L><V><Y><L><E><R><L><L><T><Y><A><E><I><D><I><C><P><A><N><W><K><R><I><V><L><G><A><I><L><L><A><S><K><V><W><D><D><Q><A><V><W><N><V><D><Y><C><Q><I><L><K><D><I><T><V><E><D><M><N><E><L><E><R><Q><F><L><E><L><L><Q><F><N><I><N><V><P><S><S><V><Y><A><K><Y><Y><F><D><L><R><S><L><A><E><A><N><N><L><S><F><P><L><E><P><L><S><R><E><R><A><H><K><L><E><A><I><S><R><L><C><E><D><K><Y><K><D><L><R><R><S><A><R><K><R><S><A><S><A><D><N><L><T><L><P><R><W><S><P><A><I><I><S>
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Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.<BOP>
|
Q8ND76
|
Q9UL59
|
ZN214_HUMAN
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BWSCR2-associated zinc finger protein 1
|
Homo
|
<M><A><V><T><F><E><D><V><T><I><I><F><T><W><E><E><W><K><F><L><D><S><S><Q><K><R><L><Y><R><E><V><M><W><E><N><Y><T><N><V><M><S><V><E><N><W><N><E><S><Y><K><S><Q><E><E><K><F><R><Y><L><E><Y><E><N><F><S><Y><W><Q><G><W><W><N><A><G><A><Q><M><Y><E><N><Q><N><Y><G><E><T><V><Q><G><T><D><S><K><D><L><T><Q><Q><D><R><S><Q><C><Q><E><W><L><I><L><S><T><Q><V><P><G><Y><G><N><Y><E><L><T><F><E><S><K><S><L><R><N><L><K><Y><K><N><F><M><P><W><Q><S><L><E><T><K><T><T><Q><D><Y><G><R><E><I><Y><M><S><G><S><H><G><F><Q><G><G><R><Y><R><L><G><I><S><R><K><N><L><S><M><E><K><E><Q><K><L><I><V><Q><H><S><Y><I><P><V><E><E><A><L><P><Q><Y><V><G><V><I><C><Q><E><D><L><L><R><D><S><M><E><E><K><Y><C><G><C><N><K><C><K><G><I><Y><Y><W><N><S><R><C><V><F><H><K><R><N><Q><P><G><E><N><L><C><Q><C><S><I><C><K><A><C><F><S><Q><R><S><D><L><Y><R><H><P><R><N><H><I><G><K><K><L><Y><G><C><D><E><V><D><G><N><F><H><Q><S><S><G><V><H><F><H><Q><R><V><H><I><G><E><V><P><Y><S><C><N><A><C><G><K><S><F><S><Q><I><S><S><L><H><N><H><Q><R><V><H><T><E><E><K><F><Y><K><I><E><C><D><K><D><L><S><R><N><S><L><L><H><I><H><Q><R><L><H><I><G><E><K><P><F><K><C><N><Q><C><G><K><S><F><N><R><S><S><V><L><H><V><H><Q><R><V><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><G><F><S><Q><S><S><N><L><R><I><H><Q><L><V><H><T><G><E><K><S><Y><K><C><E><D><C><G><K><G><F><T><Q><R><S><N><L><Q><I><H><Q><R><V><H><T><G><E><K><P><Y><K><C><D><D><C><G><K><D><F><S><H><S><S><D><L><R><I><H><Q><R><V><H><T><G><E><K><P><Y><T><C><P><E><C><G><K><G><F><S><K><S><S><K><L><H><T><H><Q><R><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><G><F><S><Q><R><S><H><L><L><I><H><Q><R><V><H><T><G><E><K><P><Y><K><C><H><D><C><G><K><G><F><S><H><S><S><N><L><H><I><H><Q><R><V><H><T><G><E><K><P><Y><Q><C><A><K><C><G><K><G><F><S><H><S><S><A><L><R><I><H><Q><R><V><H><A><G><E><K><P><Y><K><C><R><E><Y><Y><K><G><F><D><H><N><S><H><L><H><N><N><H><R><R><G><N><L>
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May be involved in transcriptional regulation.<BOP>
|
Q9UL59
|
P11509
|
CP2A6_HUMAN
|
Cytochrome P450(I)
|
Homo
|
<M><L><A><S><G><M><L><L><V><A><L><L><V><C><L><T><V><M><V><L><M><S><V><W><Q><Q><R><K><S><K><G><K><L><P><P><G><P><T><P><L><P><F><I><G><N><Y><L><Q><L><N><T><E><Q><M><Y><N><S><L><M><K><I><S><E><R><Y><G><P><V><F><T><I><H><L><G><P><R><R><V><V><V><L><C><G><H><D><A><V><R><E><A><L><V><D><Q><A><E><E><F><S><G><R><G><E><Q><A><T><F><D><W><V><F><K><G><Y><G><V><V><F><S><N><G><E><R><A><K><Q><L><R><R><F><S><I><A><T><L><R><D><F><G><V><G><K><R><G><I><E><E><R><I><Q><E><E><A><G><F><L><I><D><A><L><R><G><T><G><G><A><N><I><D><P><T><F><F><L><S><R><T><V><S><N><V><I><S><S><I><V><F><G><D><R><F><D><Y><K><D><K><E><F><L><S><L><L><R><M><M><L><G><I><F><Q><F><T><S><T><S><T><G><Q><L><Y><E><M><F><S><S><V><M><K><H><L><P><G><P><Q><Q><Q><A><F><Q><L><L><Q><G><L><E><D><F><I><A><K><K><V><E><H><N><Q><R><T><L><D><P><N><S><P><R><D><F><I><D><S><F><L><I><R><M><Q><E><E><E><K><N><P><N><T><E><F><Y><L><K><N><L><V><M><T><T><L><N><L><F><I><G><G><T><E><T><V><S><T><T><L><R><Y><G><F><L><L><L><M><K><H><P><E><V><E><A><K><V><H><E><E><I><D><R><V><I><G><K><N><R><Q><P><K><F><E><D><R><A><K><M><P><Y><M><E><A><V><I><H><E><I><Q><R><F><G><D><V><I><P><M><S><L><A><R><R><V><K><K><D><T><K><F><R><D><F><F><L><P><K><G><T><E><V><Y><P><M><L><G><S><V><L><R><D><P><S><F><F><S><N><P><Q><D><F><N><P><Q><H><F><L><N><E><K><G><Q><F><K><K><S><D><A><F><V><P><F><S><I><G><K><R><N><C><F><G><E><G><L><A><R><M><E><L><F><L><F><F><T><T><V><M><Q><N><F><R><L><K><S><S><Q><S><P><K><D><I><D><V><S><P><K><H><V><G><F><A><T><I><P><R><N><Y><T><M><S><F><L><P><R>
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Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.<BOP>
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P11509
|
Q96HE9
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PRR11_HUMAN
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Proline-rich protein 11
|
Homo
|
<M><P><K><F><K><Q><R><R><R><K><L><K><A><K><A><E><R><L><F><K><K><K><E><A><S><H><F><Q><S><K><L><I><T><P><P><P><P><P><P><S><P><E><R><V><G><I><S><S><I><D><I><S><Q><S><R><S><W><L><T><S><S><W><N><F><N><F><P><N><I><R><D><A><I><K><L><W><T><N><R><V><W><S><I><Y><S><W><C><Q><N><C><I><T><Q><S><L><E><V><L><K><D><T><I><F><P><S><R><I><C><H><R><E><L><Y><S><V><K><Q><Q><F><C><I><L><E><S><K><L><C><K><L><Q><E><A><L><K><T><I><S><E><S><S><S><C><P><S><C><G><Q><T><C><H><M><S><G><K><L><T><N><V><P><A><C><V><L><I><T><P><G><D><S><K><A><V><L><P><P><T><L><P><Q><P><A><S><H><F><P><P><P><P><P><P><P><P><L><P><P><P><P><P><P><L><A><P><V><L><L><R><K><P><S><L><A><K><A><L><Q><A><G><P><L><K><K><D><G><P><M><Q><I><T><V><K><D><L><L><T><V><K><L><K><K><T><Q><S><L><D><E><K><R><K><L><I><P><S><P><K><A><R><N><P><L><V><T><V><S><D><L><Q><H><V><T><L><K><P><N><S><K><V><L><S><T><R><V><T><N><V><L><I><T><P><G><K><S><Q><M><D><L><R><K><L><L><R><K><V><D><V><E><R><S><P><G><G><T><P><L><T><N><K><E><N><M><E><T><G><T><G><L><T><P><V><M><T><Q><A><L><R><R><K><F><Q><L><A><H><P><R><S><P><T><P><T><L><P><L><S><T><S><S><F><D><E><Q><N>
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Plays a critical role in cell cycle progression.<BOP>
|
Q96HE9
|
Q00765
|
REEP5_HUMAN
|
Protein TB2
|
Homo
|
<M><S><A><A><M><R><E><R><F><D><R><F><L><H><E><K><N><C><M><T><D><L><L><A><K><L><E><A><K><T><G><V><N><R><S><F><I><A><L><G><V><I><G><L><V><A><L><Y><L><V><F><G><Y><G><A><S><L><L><C><N><L><I><G><F><G><Y><P><A><Y><I><S><I><K><A><I><E><S><P><N><K><E><D><D><T><Q><W><L><T><Y><W><V><V><Y><G><V><F><S><I><A><E><F><F><S><D><I><F><L><S><W><F><P><F><Y><Y><M><L><K><C><G><F><L><L><W><C><M><A><P><S><P><S><N><G><A><E><L><L><Y><K><R><I><I><R><P><F><F><L><K><H><E><S><Q><M><D><S><V><V><K><D><L><K><D><K><A><K><E><T><A><D><A><I><T><K><E><A><K><K><A><T><V><N><L><L><G><E><E><K><K><S><T>
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Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.<BOP>
|
Q00765
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P30939
|
5HT1F_HUMAN
|
Serotonin receptor 1F
|
Homo
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<M><D><F><L><N><S><S><D><Q><N><L><T><S><E><E><L><L><N><R><M><P><S><K><I><L><V><S><L><T><L><S><G><L><A><L><M><T><T><T><I><N><S><L><V><I><A><A><I><I><V><T><R><K><L><H><H><P><A><N><Y><L><I><C><S><L><A><V><T><D><F><L><V><A><V><L><V><M><P><F><S><I><V><Y><I><V><R><E><S><W><I><M><G><Q><V><V><C><D><I><W><L><S><V><D><I><T><C><C><T><C><S><I><L><H><L><S><A><I><A><L><D><R><Y><R><A><I><T><D><A><V><E><Y><A><R><K><R><T><P><K><H><A><G><I><M><I><T><I><V><W><I><I><S><V><F><I><S><M><P><P><L><F><W><R><H><Q><G><T><S><R><D><D><E><C><I><I><K><H><D><H><I><V><S><T><I><Y><S><T><F><G><A><F><Y><I><P><L><A><L><I><L><I><L><Y><Y><K><I><Y><R><A><A><K><T><L><Y><H><K><R><Q><A><S><R><I><A><K><E><E><V><N><G><Q><V><L><L><E><S><G><E><K><S><T><K><S><V><S><T><S><Y><V><L><E><K><S><L><S><D><P><S><T><D><F><D><K><I><H><S><T><V><R><S><L><R><S><E><F><K><H><E><K><S><W><R><R><Q><K><I><S><G><T><R><E><R><K><A><A><T><T><L><G><L><I><L><G><A><F><V><I><C><W><L><P><F><F><V><K><E><L><V><V><N><V><C><D><K><C><K><I><S><E><E><M><S><N><F><L><A><W><L><G><Y><L><N><S><L><I><N><P><L><I><Y><T><I><F><N><E><D><F><K><K><A><F><Q><K><L><V><R><C><R><C>
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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<BOP>
|
P30939
|
Q9P291
|
ARMX1_HUMAN
|
ARM protein lost in epithelial cancers on chromosome X 1
|
Homo
|
<M><G><R><T><R><E><A><G><C><V><A><A><G><V><V><I><G><A><G><A><C><Y><C><V><Y><R><L><A><W><G><R><D><E><N><E><K><I><W><D><E><D><E><E><S><T><D><T><S><E><I><G><V><E><T><V><K><G><A><K><T><N><A><G><A><G><S><G><A><K><L><Q><G><D><S><E><V><K><P><E><V><S><L><G><L><E><D><C><P><G><V><K><E><K><A><H><S><G><S><H><S><G><G><G><L><E><A><K><A><K><A><L><F><N><T><L><K><E><Q><A><S><A><K><A><G><K><G><A><R><V><G><T><I><S><G><N><R><T><L><A><P><S><L><P><C><P><G><G><R><G><G><G><C><H><P><T><R><S><G><S><R><A><G><G><R><A><S><G><K><S><K><G><K><A><R><S><K><S><T><R><A><P><A><T><T><W><P><V><R><R><G><K><F><N><F><P><Y><K><I><D><D><I><L><S><A><P><D><L><Q><K><V><L><N><I><L><E><R><T><N><D><P><F><I><Q><E><V><A><L><V><T><L><G><N><N><A><A><Y><S><F><N><Q><N><A><I><R><E><L><G><G><V><P><I><I><A><K><L><I><K><T><K><D><P><I><I><R><E><K><T><Y><N><A><L><N><N><L><S><V><N><A><E><N><Q><G><K><I><K><T><Y><I><S><Q><V><C><D><D><T><M><V><C><R><L><D><S><A><V><Q><M><A><G><L><R><L><L><T><N><M><T><V><T><N><H><Y><Q><H><L><L><S><Y><S><F><P><D><F><F><A><L><L><F><L><G><N><H><F><T><K><I><Q><I><M><K><L><I><I><N><F><T><E><N><P><A><M><T><R><E><L><V><S><C><K><V><P><S><E><L><I><S><L><F><N><K><E><W><D><R><E><I><L><L><N><I><L><T><L><F><E><N><I><N><D><N><I><K><N><E><G><L><A><S><S><R><K><E><F><S><R><S><S><L><F><F><L><F><K><E><S><G><V><C><V><K><K><I><K><A><L><A><N><H><N><D><L><V><V><K><V><K><V><L><K><V><L><T><K><L>
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Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.<BOP>
|
Q9P291
|
P62942
|
FKB1A_HUMAN
|
Rotamase
|
Homo
|
<M><G><V><Q><V><E><T><I><S><P><G><D><G><R><T><F><P><K><R><G><Q><T><C><V><V><H><Y><T><G><M><L><E><D><G><K><K><F><D><S><S><R><D><R><N><K><P><F><K><F><M><L><G><K><Q><E><V><I><R><G><W><E><E><G><V><A><Q><M><S><V><G><Q><R><A><K><L><T><I><S><P><D><Y><A><Y><G><A><T><G><H><P><G><I><I><P><P><H><A><T><L><V><F><D><V><E><L><L><K><L><E>
|
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<BOP>
|
P62942
|
P08238
|
HS90B_HUMAN
|
Heat shock 84 kDa
|
Homo
|
<M><P><E><E><V><H><H><G><E><E><E><V><E><T><F><A><F><Q><A><E><I><A><Q><L><M><S><L><I><I><N><T><F><Y><S><N><K><E><I><F><L><R><E><L><I><S><N><A><S><D><A><L><D><K><I><R><Y><E><S><L><T><D><P><S><K><L><D><S><G><K><E><L><K><I><D><I><I><P><N><P><Q><E><R><T><L><T><L><V><D><T><G><I><G><M><T><K><A><D><L><I><N><N><L><G><T><I><A><K><S><G><T><K><A><F><M><E><A><L><Q><A><G><A><D><I><S><M><I><G><Q><F><G><V><G><F><Y><S><A><Y><L><V><A><E><K><V><V><V><I><T><K><H><N><D><D><E><Q><Y><A><W><E><S><S><A><G><G><S><F><T><V><R><A><D><H><G><E><P><I><G><R><G><T><K><V><I><L><H><L><K><E><D><Q><T><E><Y><L><E><E><R><R><V><K><E><V><V><K><K><H><S><Q><F><I><G><Y><P><I><T><L><Y><L><E><K><E><R><E><K><E><I><S><D><D><E><A><E><E><E><K><G><E><K><E><E><E><D><K><D><D><E><E><K><P><K><I><E><D><V><G><S><D><E><E><D><D><S><G><K><D><K><K><K><K><T><K><K><I><K><E><K><Y><I><D><Q><E><E><L><N><K><T><K><P><I><W><T><R><N><P><D><D><I><T><Q><E><E><Y><G><E><F><Y><K><S><L><T><N><D><W><E><D><H><L><A><V><K><H><F><S><V><E><G><Q><L><E><F><R><A><L><L><F><I><P><R><R><A><P><F><D><L><F><E><N><K><K><K><K><N><N><I><K><L><Y><V><R><R><V><F><I><M><D><S><C><D><E><L><I><P><E><Y><L><N><F><I><R><G><V><V><D><S><E><D><L><P><L><N><I><S><R><E><M><L><Q><Q><S><K><I><L><K><V><I><R><K><N><I><V><K><K><C><L><E><L><F><S><E><L><A><E><D><K><E><N><Y><K><K><F><Y><E><A><F><S><K><N><L><K><L><G><I><H><E><D><S><T><N><R><R><R><L><S><E><L><L><R><Y><H><T><S><Q><S><G><D><E><M><T><S><L><S><E><Y><V><S><R><M><K><E><T><Q><K><S><I><Y><Y><I><T><G><E><S><K><E><Q><V><A><N><S><A><F><V><E><R><V><R><K><R><G><F><E><V><V><Y><M><T><E><P><I><D><E><Y><C><V><Q><Q><L><K><E><F><D><G><K><S><L><V><S><V><T><K><E><G><L><E><L><P><E><D><E><E><E><K><K><K><M><E><E><S><K><A><K><F><E><N><L><C><K><L><M><K><E><I><L><D><K><K><V><E><K><V><T><I><S><N><R><L><V><S><S><P><C><C><I><V><T><S><T><Y><G><W><T><A><N><M><E><R><I><M><K><A><Q><A><L><R><D><N><S><T><M><G><Y><M><M><A><K><K><H><L><E><I><N><P><D><H><P><I><V><E><T><L><R><Q><K><A><E><A><D><K><N><D><K><A><V><K><D><L><V><V><L><L><F><E><T><A><L><L><S><S><G><F><S><L><E><D><P><Q><T><H><S><N><R><I><Y><R><M><I><K><L><G><L><G><I><D><E><D><E><V><A><A><E><E><P><N><A><A><V><P><D><E><I><P><P><L><E><G><D><E><D><A><S><R><M><E><E><V><D>
|
(Microbial infection) Binding to N.meningitidis NadA stimulates monocytes . Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable).<BOP>
|
P08238
|
Q96EC8
|
YIPF6_HUMAN
|
YIP1 family member 6
|
Homo
|
<M><A><E><A><E><E><S><P><G><D><P><G><T><A><S><P><R><P><L><F><A><G><L><S><D><I><S><I><S><Q><D><I><P><V><E><G><E><I><T><I><P><M><R><S><R><I><R><E><F><D><S><S><T><L><N><E><S><V><R><N><T><I><M><R><D><L><K><A><V><G><K><K><F><M><H><V><L><Y><P><R><K><S><N><T><L><L><R><D><W><D><L><W><G><P><L><I><L><C><V><T><L><A><L><M><L><Q><R><D><S><A><D><S><E><K><D><G><G><P><Q><F><A><E><V><F><V><I><V><W><F><G><A><V><T><I><T><L><N><S><K><L><L><G><G><N><I><S><F><F><Q><S><L><C><V><L><G><Y><C><I><L><P><L><T><V><A><M><L><I><C><R><L><V><L><L><A><D><P><G><P><V><N><F><M><V><R><L><F><V><V><I><V><M><F><A><W><S><I><V><A><S><T><A><F><L><A><D><S><Q><P><P><N><R><R><A><L><A><V><Y><P><V><F><L><F><Y><F><V><I><S><W><M><I><L><T><F><T><P><Q>
|
May be required for stable YIPF1 and YIPF2 protein expression.<BOP>
|
Q96EC8
|
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