accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1
value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
P04183 | KITH_HUMAN | Thymidine kinase, cytosolic | Homo | <M><S><C><I><N><L><P><T><V><L><P><G><S><P><S><K><T><R><G><Q><I><Q><V><I><L><G><P><M><F><S><G><K><S><T><E><L><M><R><R><V><R><R><F><Q><I><A><Q><Y><K><C><L><V><I><K><Y><A><K><D><T><R><Y><S><S><S><F><C><T><H><D><R><N><T><M><E><A><L><P><A><C><L><L><R><D><V><A><Q><E><A><L><G><V><A><V><I><G><I><D><E><G><Q><F><F><P><D><I><V><E... | Cell-cycle-regulated enzyme of importance in nucleotide metabolism . Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate . Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the ... | P04183 |
Q3LI83 | KR241_HUMAN | Keratin-associated protein 24-1 | Homo | <M><P><A><G><S><M><S><T><T><G><Y><P><G><V><C><S><T><T><S><Y><R><T><H><C><Y><I><P><V><T><S><S><V><T><L><S><S><S><D><L><S><P><T><F><G><H><C><L><P><S><S><Y><Q><G><N><L><W><L><L><D><Y><C><Q><E><S><Y><G><E><A><P><T><C><K><S><P><S><C><E><P><K><T><C><S><T><T><G><C><D><P><S><N><S><S><V><P><C><N><S><P><S><A><G><Q><V><F><S><V><C... | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of ha... | Q3LI83 |
O43395 | PRPF3_HUMAN | U4/U6 snRNP 90 kDa protein | Homo | <M><A><L><S><K><R><E><L><D><E><L><K><P><W><I><E><K><T><V><K><R><V><L><G><F><S><E><P><T><V><V><T><A><A><L><N><C><V><G><K><G><M><D><K><K><K><A><A><D><H><L><K><P><F><L><D><D><S><T><L><R><F><V><D><K><L><F><E><A><V><E><E><G><R><S><S><R><H><S><K><S><S><S><D><R><S><R><K><R><E><L><K><E><V><F><G><D><D><S><E><I><S><K><E><S><S><G... | Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).<BOP> | O43395 |
Q6UXS9 | CASPC_HUMAN | Inactive caspase-12 | Homo | <M><A><D><E><K><P><S><N><G><V><L><V><H><M><V><K><L><L><I><K><T><F><L><D><G><I><F><D><D><L><M><E><N><N><V><L><N><T><D><E><I><H><L><I><G><K><C><L><K><F><V><V><S><N><A><E><N><L><V><D><D><I><T><E><T><A><Q><I><A><G><K><I><F><R><E><H><L><W><N><S><K><K><Q><L><S><S><D><I><S><S><D><G><E><R><E><A><N><M><P><G><L><N><I><R><N><K><E... | Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.<BOP> | Q6UXS9 |
Q9BXS1 | IDI2_HUMAN | Isopentenyl pyrophosphate isomerase 2 | Homo | <M><S><D><I><N><L><D><W><V><D><R><R><Q><L><Q><R><L><E><E><M><L><I><V><V><D><E><N><D><K><V><I><G><A><D><T><K><R><N><C><H><L><N><E><N><I><E><K><G><L><L><H><R><A><F><S><V><V><L><F><N><T><K><N><R><I><L><I><Q><Q><R><S><D><T><K><V><T><F><P><G><Y><F><T><D><S><C><S><S><H><P><L><Y><N><P><A><E><L><E><E><K><D><A><I><G><V><R><R><A... | Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).<BOP> | Q9BXS1 |
O14521 | DHSD_HUMAN | Succinate-ubiquinone reductase membrane anchor subunit | Homo | <M><A><V><L><W><R><L><S><A><V><C><G><A><L><G><G><R><A><L><L><L><R><T><P><V><V><R><P><A><H><I><S><A><F><L><Q><D><R><P><I><P><E><W><C><G><V><Q><H><I><H><L><S><P><S><H><H><S><G><S><K><A><A><S><L><H><W><T><S><E><R><V><V><S><V><L><L><L><G><L><L><P><A><A><Y><L><N><P><C><S><A><M><D><Y><S><L><A><A><A><L><T><L><H><G><H><W><G><L... | Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).<BOP> | O14521 |
Q9BZD6 | TMG4_HUMAN | Proline-rich gamma-carboxyglutamic acid protein 4 | Homo | <M><F><T><L><L><V><L><L><S><Q><L><P><T><V><T><L><G><F><P><H><C><A><R><G><P><K><A><S><K><H><A><G><E><E><V><F><T><S><K><E><E><A><N><F><F><I><H><R><R><L><L><Y><N><R><F><D><L><E><L><F><T><P><G><N><L><E><R><E><C><N><E><E><L><C><N><Y><E><E><A><R><E><I><F><V><D><E><D><K><T><I><A><F><W><Q><E><Y><S><A><K><G><P><T><T><K><S><D><G... | May control axon guidance across the CNS . Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression .<BOP> | Q9BZD6 |
Q6B0I6 | KDM4D_HUMAN | [histone H3]-trimethyl-L-lysine(9) demethylase 4D | Homo | <M><E><T><M><K><S><K><A><N><C><A><Q><N><P><N><C><N><I><M><I><F><H><P><T><K><E><E><F><N><D><F><D><K><Y><I><A><Y><M><E><S><Q><G><A><H><R><A><G><L><A><K><I><I><P><P><K><E><W><K><A><R><E><T><Y><D><N><I><S><E><I><L><I><A><T><P><L><Q><Q><V><A><S><G><R><A><G><V><F><T><Q><Y><H><K><K><K><K><A><M><T><V><G><E><Y><R><H><L><A><N><S... | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. De... | Q6B0I6 |
P0C629 | O10J4_HUMAN | Olfactory receptor 10J4 | Homo | <M><P><R><P><N><F><M><A><V><T><E><F><T><F><E><G><F><S><I><F><E><W><H><H><R><L><I><L><F><V><I><F><L><V><L><Y><V><L><T><L><A><S><N><A><I><I><L><I><V><I><R><L><N><H><Q><L><H><T><P><M><Y><F><F><L><S><V><L><S><I><S><E><T><Y><Y><T><V><A><I><N><P><Q><M><L><S><G><L><L><S><P><Q><Q><T><I><S><I><P><G><C><A><A><Q><L><F><F><Y><L><T... | Odorant receptor.<BOP> | P0C629 |
P08861 | CEL3B_HUMAN | Protease E | Homo | <M><M><L><R><L><L><S><S><L><L><L><V><A><V><A><S><G><Y><G><P><P><S><S><R><P><S><S><R><V><V><N><G><E><D><A><V><P><Y><S><W><P><W><Q><V><S><L><Q><Y><E><K><S><G><S><F><Y><H><T><C><G><G><S><L><I><A><P><D><W><V><V><T><A><G><H><C><I><S><S><S><R><T><Y><Q><V><V><L><G><E><Y><D><R><A><V><K><E><G><P><E><Q><V><I><P><I><N><S><G><D><L... | Efficient protease with alanine specificity but only little elastolytic activity.<BOP> | P08861 |
A1L190 | SYCE3_HUMAN | Testis highly expressed gene 2 protein | Homo | <M><D><D><A><D><P><E><E><R><N><Y><D><N><M><L><K><M><L><S><D><L><N><K><D><L><E><K><L><L><E><E><M><E><K><I><S><V><Q><A><T><W><M><A><Y><D><M><V><V><M><R><T><N><P><T><L><A><E><S><M><R><R><L><E><D><A><F><V><N><C><K><E><E><M><E><K><N><W><Q><E><L><L><H><E><T><K><Q><R><L> | Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to requir... | A1L190 |
Q96BV0 | ZN775_HUMAN | Zinc finger protein 775 | Homo | <M><E><S><G><L><A><G><N><G><T><G><A><G><L><V><M><K><V><K><Q><E><K><P><E><R><L><L><Q><T><L><A><P><Q><A><M><L><V><E><K><D><K><E><N><I><F><Q><Q><H><R><G><L><P><P><R><Q><T><M><G><R><P><R><A><L><G><G><Q><E><E><S><G><S><P><R><W><A><P><P><T><E><Q><D><A><G><L><A><G><R><A><P><G><S><A><S><G><P><L><S><P><S><L><S><S><G><E><G><H><F... | May be involved in transcriptional regulation.<BOP> | Q96BV0 |
Q9GZT8 | NIF3L_HUMAN | Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein | Homo | <M><L><S><S><C><V><R><P><V><P><T><T><V><R><F><V><D><S><L><I><C><N><S><S><R><S><F><M><D><L><K><A><L><L><S><S><L><N><D><F><A><S><L><S><F><A><E><S><W><D><N><V><G><L><L><V><E><P><S><P><P><H><T><V><N><T><L><F><L><T><N><D><L><T><E><E><V><M><E><E><V><L><Q><K><K><A><D><L><I><L><S><Y><H><P><P><I><F><R><P><M><K><R><I><T><W><N><T... | May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.<BOP> | Q9GZT8 |
P10147 | CCL3_HUMAN | LD78-alpha(4-69) | Homo | <M><Q><V><S><T><A><A><L><A><V><L><L><C><T><M><A><L><C><N><Q><F><S><A><S><L><A><A><D><T><P><T><A><C><C><F><S><Y><T><S><R><Q><I><P><Q><N><F><I><A><D><Y><F><E><T><S><S><Q><C><S><K><P><G><V><I><F><L><T><K><R><S><R><Q><V><C><A><D><P><S><E><E><W><V><Q><K><Y><V><S><D><L><E><L><S><A> | Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).<BOP> | P10147 |
Q13304 | GPR17_HUMAN | R12 | Homo | <M><S><K><R><S><W><W><A><G><S><R><K><P><P><R><E><M><L><K><L><S><G><S><D><S><S><Q><S><M><N><G><L><E><V><A><P><P><G><L><I><T><N><F><S><L><A><T><A><E><Q><C><G><Q><E><T><P><L><E><N><M><L><F><A><S><F><Y><L><L><D><F><I><L><A><L><V><G><N><T><L><A><L><W><L><F><I><R><D><H><K><S><G><T><P><A><N><V><F><L><M><H><L><A><V><A><D><L><S... | Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.<BOP> | Q13304 |
Q9BYZ8 | REG4_HUMAN | Regenerating islet-derived protein IV | Homo | <M><A><S><R><S><M><R><L><L><L><L><L><S><C><L><A><K><T><G><V><L><G><D><I><I><M><R><P><S><C><A><P><G><W><F><Y><H><K><S><N><C><Y><G><Y><F><R><K><L><R><N><W><S><D><A><E><L><E><C><Q><S><Y><G><N><G><A><H><L><A><S><I><L><S><L><K><E><A><S><T><I><A><E><Y><I><S><G><Y><Q><R><S><Q><P><I><W><I><G><L><H><D><P><Q><K><R><Q><Q><W><Q><W... | Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.<BOP> | Q9BYZ8 |
Q53QV2 | LBH_HUMAN | Limb bud and heart development protein homolog | Homo | <M><S><I><Y><F><P><I><H><C><P><D><Y><L><R><S><A><K><M><T><E><V><M><M><N><T><Q><P><M><E><E><I><G><L><S><P><R><K><D><G><L><S><Y><Q><I><F><P><D><P><S><D><F><D><R><C><C><K><L><K><D><R><L><P><S><I><V><V><E><P><T><E><G><E><V><E><S><G><E><L><R><W><P><P><E><E><F><L><V><Q><E><D><E><Q><D><N><C><E><E><T><A><K><E><N><K><E><Q> | Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.<BOP> | Q53QV2 |
P34925 | RYK_HUMAN | Tyrosine-protein kinase RYK | Homo | <M><R><G><A><A><R><L><G><R><P><G><R><S><C><L><P><G><A><R><G><L><R><A><P><P><P><P><P><L><L><L><L><L><A><L><L><P><L><L><P><A><P><G><A><A><A><A><P><A><P><R><P><P><E><L><Q><S><A><S><A><G><P><S><V><S><L><Y><L><S><E><D><E><V><R><R><L><I><G><L><D><A><E><L><Y><Y><V><R><N><D><L><I><S><H><Y><A><L><S><F><S><L><L><V><P><S><E><T><N... | May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal int... | P34925 |
Q9UKY4 | POMT2_HUMAN | Dolichyl-phosphate-mannose--protein mannosyltransferase 2 | Homo | <M><P><P><A><T><G><G><G><L><A><E><S><E><L><R><P><R><R><G><R><C><G><P><Q><A><A><R><A><A><G><R><D><V><A><A><E><A><V><A><R><S><P><K><R><P><A><W><G><S><R><R><F><E><A><V><G><W><W><A><L><L><A><L><V><T><L><L><S><F><A><T><R><F><H><R><L><D><E><P><P><H><I><C><W><D><E><T><H><F><G><K><M><G><S><Y><Y><I><N><R><T><F><F><F><D><V><H><P... | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient . Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and pro... | Q9UKY4 |
Q9NR64 | KLHL1_HUMAN | Kelch-like protein 1 | Homo | <M><S><G><S><G><R><K><D><F><D><V><K><H><I><L><R><L><R><W><K><L><F><S><H><P><S><P><S><T><G><G><P><A><G><G><G><C><L><Q><Q><D><G><S><G><S><F><E><H><W><G><P><S><Q><S><R><L><L><K><S><Q><E><R><S><G><V><S><T><F><W><K><K><P><S><S><S><S><S><S><S><S><S><P><S><S><S><S><S><S><F><N><P><L><N><G><T><L><L><P><V><A><T><R><L><Q><Q><G><A... | May play a role in organizing the actin cytoskeleton of the brain cells.<BOP> | Q9NR64 |
Q8NGP6 | OR5M8_HUMAN | Olfactory receptor OR11-194 | Homo | <M><R><R><N><C><T><L><V><T><E><F><I><L><L><G><L><T><S><R><R><E><L><Q><I><L><L><F><T><L><F><L><A><I><Y><M><V><T><V><A><G><N><L><G><M><I><V><L><I><Q><A><N><A><W><L><H><M><P><M><Y><F><F><L><S><H><L><S><F><V><D><L><C><F><S><S><N><V><T><P><K><M><L><E><I><F><L><S><E><K><K><S><I><S><Y><P><A><C><L><V><Q><C><Y><L><F><I><A><L><V... | Odorant receptor.<BOP> | Q8NGP6 |
P30043 | BLVRB_HUMAN | NADPH-flavin reductase | Homo | <M><A><V><K><K><I><A><I><F><G><A><T><G><Q><T><G><L><T><T><L><A><Q><A><V><Q><A><G><Y><E><V><T><V><L><V><R><D><S><S><R><L><P><S><E><G><P><R><P><A><H><V><V><V><G><D><V><L><Q><A><A><D><V><D><K><T><V><A><G><Q><D><A><V><I><V><L><L><G><T><R><N><D><L><S><P><T><T><V><M><S><E><G><A><R><N><I><V><A><A><M><K><A><H><G><V><D><K><V><V... | Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) i... | P30043 |
Q96MN9 | ZN488_HUMAN | Zinc finger protein 488 | Homo | <M><P><E><W><P><P><C><L><S><V><A><P><A><L><V><I><T><M><A><A><G><K><G><A><P><L><S><P><S><A><E><N><R><W><R><L><S><E><P><E><L><G><R><G><C><K><P><V><L><L><E><K><T><N><R><L><G><P><E><A><A><V><G><R><A><G><R><D><V><G><S><A><E><L><A><L><L><V><A><P><G><K><P><R><P><G><K><P><L><P><P><K><T><R><G><E><Q><R><Q><S><A><F><T><E><L><P><R... | Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerv... | Q96MN9 |
Q5VZ03 | NXNL2_HUMAN | Rod-derived cone viability factor 2 | Homo | <M><V><D><I><L><G><E><R><H><L><V><T><C><K><G><A><T><V><E><A><E><A><A><L><Q><N><K><V><V><A><L><Y><F><A><A><A><R><C><A><P><S><R><D><F><T><P><L><L><C><D><F><Y><T><A><L><V><A><E><A><R><R><P><A><P><F><E><V><V><F><V><S><A><D><G><S><S><Q><E><M><L><D><F><M><R><E><L><H><G><A><W><L><A><L><P><F><H><D><P><Y><R><H><E><L><R><K><R><Y... | May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons.<BOP> | Q5VZ03 |
P18847 | ATF3_HUMAN | Activating transcription factor 3 | Homo | <M><M><L><Q><H><P><G><Q><V><S><A><S><E><V><S><A><S><A><I><V><P><C><L><S><P><P><G><S><L><V><F><E><D><F><A><N><L><T><P><F><V><K><E><E><L><R><F><A><I><Q><N><K><H><L><C><H><R><M><S><S><A><L><E><S><V><T><V><S><D><R><P><L><G><V><S><I><T><K><A><E><V><A><P><E><E><D><E><R><K><K><R><R><R><E><R><N><K><I><A><A><A><K><C><R><N><K><K... | Stress-induced isoform, counteracts the transcriptional repression of isoform 1.<BOP> | P18847 |
P25116 | PAR1_HUMAN | Thrombin receptor | Homo | <M><G><P><R><R><L><L><L><V><A><A><C><F><S><L><C><G><P><L><L><S><A><R><T><R><A><R><R><P><E><S><K><A><T><N><A><T><L><D><P><R><S><F><L><L><R><N><P><N><D><K><Y><E><P><F><W><E><D><E><E><K><N><E><S><G><L><T><E><Y><R><L><V><S><I><N><K><S><S><P><L><Q><K><Q><L><P><A><F><I><S><E><D><A><S><G><Y><L><T><S><S><W><L><T><L><F><V><P><S... | High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.<BOP> | P25116 |
Q5T751 | LCE1C_HUMAN | Late envelope protein 3 | Homo | <M><S><C><Q><Q><S><Q><Q><Q><C><Q><P><P><P><K><C><T><P><K><C><P><P><K><C><P><T><P><K><C><P><P><K><C><P><P><K><C><P><P><V><S><S><C><C><S><V><S><S><G><G><C><C><G><S><S><S><G><G><S><C><G><S><S><S><G><G><C><C><S><S><G><G><G><G><C><C><L><S><H><H><R><R><R><R><S><H><C><H><R><P><Q><S><S><G><C><C><S><Q><P><S><G><G><S><S><C><C><G... | Precursors of the cornified envelope of the stratum corneum.<BOP> | Q5T751 |
P0CG48 | UBC_HUMAN | Ubiquitin | Homo | <M><Q><I><F><V><K><T><L><T><G><K><T><I><T><L><E><V><E><P><S><D><T><I><E><N><V><K><A><K><I><Q><D><K><E><G><I><P><P><D><Q><Q><R><L><I><F><A><G><K><Q><L><E><D><G><R><T><L><S><D><Y><N><I><Q><K><E><S><T><L><H><L><V><L><R><L><R><G><G><M><Q><I><F><V><K><T><L><T><G><K><T><I><T><L><E><V><E><P><S><D><T><I><E><N><V><K><A><K><I><Q... | Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initia... | P0CG48 |
P13645 | K1C10_HUMAN | Keratin-10 | Homo | <M><S><V><R><Y><S><S><S><K><H><Y><S><S><S><R><S><G><G><G><G><G><G><G><G><C><G><G><G><G><G><V><S><S><L><R><I><S><S><S><K><G><S><L><G><G><G><F><S><S><G><G><F><S><G><G><S><F><S><R><G><S><S><G><G><G><C><F><G><G><S><S><G><G><Y><G><G><L><G><G><F><G><G><G><S><F><R><G><S><Y><G><S><S><S><F><G><G><S><Y><G><G><I><F><G><G><G><S><F... | (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.<BOP> | P13645 |
Q9UKW6 | ELF5_HUMAN | Epithelium-specific Ets transcription factor 2 | Homo | <M><P><S><L><P><H><S><H><R><V><M><L><D><S><V><T><H><S><T><F><L><P><N><A><S><F><C><D><P><L><M><S><W><T><D><L><F><S><N><E><E><Y><Y><P><A><F><E><H><Q><T><A><C><D><S><Y><W><T><S><V><H><P><E><Y><W><T><K><R><H><V><W><E><W><L><Q><F><C><C><D><Q><Y><K><L><D><T><N><C><I><S><F><C><N><F><N><I><S><G><L><Q><L><C><S><M><T><Q><E><E><F... | Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.<BOP> | Q9UKW6 |
Q15699 | ALX1_HUMAN | Cartilage homeoprotein 1 | Homo | <M><E><F><L><S><E><K><F><A><L><K><S><P><P><S><K><N><S><D><F><Y><M><G><A><G><G><P><L><E><H><V><M><E><T><L><D><N><E><S><F><Y><S><K><A><S><A><G><K><C><V><Q><A><F><G><P><L><P><R><A><E><H><H><V><R><L><E><R><T><S><P><C><Q><D><S><S><V><N><Y><G><I><T><K><V><E><G><Q><P><L><H><T><E><L><N><R><A><M><D><N><C><N><S><L><R><M><S><P><V... | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes . Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it... | Q15699 |
Q9BYQ7 | KRA41_HUMAN | Ultrahigh sulfur keratin-associated protein 4.10 | Homo | <M><V><N><S><C><C><G><S><V><C><S><D><Q><G><C><D><Q><G><L><C><Q><E><T><C><C><R><P><S><C><C><Q><T><T><C><C><C><P><S><C><V><V><S><S><C><C><R><P><S><C><S><Q><T><T><C><C><Q><T><T><C><C><R><P><S><C><C><H><P><V><C><C><Q><T><T><C><R><P><S><C><G><V><S><S><C><C><R><P><L><C><C><Q><T><T><C><H><P><S><C><G><M><S><S><C><C><R><P><L><C... | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of ha... | Q9BYQ7 |
P28221 | 5HT1D_HUMAN | Serotonin receptor 1D | Homo | <M><S><P><L><N><Q><S><A><E><G><L><P><Q><E><A><S><N><R><S><L><N><A><T><E><T><S><E><A><W><D><P><R><T><L><Q><A><L><K><I><S><L><A><V><V><L><S><V><I><T><L><A><T><V><L><S><N><A><F><V><L><T><T><I><L><L><T><R><K><L><H><T><P><A><N><Y><L><I><G><S><L><A><T><T><D><L><L><V><S><I><L><V><M><P><I><S><I><A><Y><T><I><T><H><T><W><N><F><G... | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G prote... | P28221 |
Q969E2 | SCAM4_HUMAN | Secretory carrier-associated membrane protein 4 | Homo | <M><S><E><K><E><N><N><F><P><P><L><P><K><F><I><P><V><K><P><C><F><Y><Q><N><F><S><D><E><I><P><V><E><H><Q><V><L><V><K><R><I><Y><R><L><W><M><F><Y><C><A><T><L><G><V><N><L><I><A><C><L><A><W><W><I><G><G><G><S><G><T><N><F><G><L><A><F><V><W><L><L><L><F><T><P><C><G><Y><V><C><W><F><R><P><V><Y><K><A><F><R><A><D><S><S><F><N><F><M><A... | Probably involved in membrane protein trafficking.<BOP> | Q969E2 |
Q8TDU5 | VNRL4_HUMAN | G-protein coupled receptor GPCR23 | Homo | <M><E><M><T><K><L><F><S><Y><I><V><I><K><N><V><Y><Y><P><Q><V><S><F><G><I><S><A><N><T><F><L><L><L><F><H><I><F><T><F><A><Y><T><H><R><L><K><P><I><D><M><T><I><S><H><L><P><L><I><H><I><L><L><L><F><T><Q><A><I><L><V><S><S><D><L><F><E><S><W><N><I><Q><N><N><D><L><K><C><K><I><I><T><F><L><N><R><V><M><R><G><V><S><I><C><T><T><C><L><L... | Putative pheromone receptor.<BOP> | Q8TDU5 |
O15260 | SURF4_HUMAN | Surfeit locus protein 4 | Homo | <M><G><Q><N><D><L><M><G><T><A><E><D><F><A><D><Q><F><L><R><V><T><K><Q><Y><L><P><H><V><A><R><L><C><L><I><S><T><F><L><E><D><G><I><R><M><W><F><Q><W><S><E><Q><R><D><Y><I><D><T><T><W><N><C><G><Y><L><L><A><S><S><F><V><F><L><N><L><L><G><Q><L><T><G><C><V><L><V><L><S><R><N><F><V><Q><Y><A><C><F><G><L><F><G><I><I><A><L><Q><T><I><A... | Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion . Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis . Synergizes with... | O15260 |
Q9Y600 | CSAD_HUMAN | Sulfinoalanine decarboxylase | Homo | <M><A><D><S><E><A><L><P><S><L><A><G><D><P><V><A><V><E><A><L><L><R><A><V><F><G><V><V><V><D><E><A><I><Q><K><G><T><S><V><S><Q><K><V><C><E><W><K><E><P><E><E><L><K><Q><L><L><D><L><E><L><R><S><Q><G><E><S><Q><K><Q><I><L><E><R><C><R><A><V><I><R><Y><S><V><K><T><G><H><P><R><F><F><N><Q><L><F><S><G><L><D><P><H><A><L><A><G><R><I><I... | Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate.<BOP> | Q9Y600 |
Q86XT9 | TM219_HUMAN | Transmembrane protein 219 | Homo | <M><G><N><C><Q><A><G><H><N><L><H><L><C><L><A><H><H><P><P><L><V><C><A><T><L><I><L><L><L><L><G><L><S><G><L><G><L><G><S><F><L><L><T><H><R><T><G><L><R><S><P><D><I><P><Q><D><W><V><S><F><L><R><S><F><G><Q><L><T><L><C><P><R><N><G><T><V><T><G><K><W><R><G><S><H><V><V><G><L><L><T><T><L><N><F><G><D><G><P><D><R><N><K><T><R><T><F><Q... | Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.<BOP> | Q86XT9 |
O00628 | PEX7_HUMAN | Peroxin-7 | Homo | <M><S><A><V><C><G><G><A><A><R><M><L><R><T><P><G><R><H><G><Y><A><A><E><F><S><P><Y><L><P><G><R><L><A><C><A><T><A><Q><H><Y><G><I><A><G><C><G><T><L><L><I><L><D><P><D><E><A><G><L><R><L><F><R><S><F><D><W><N><D><G><L><F><D><V><T><W><S><E><N><N><E><H><V><L><I><T><C><S><G><D><G><S><L><Q><L><W><D><T><A><K><A><A><G><P><L><Q><V><Y... | Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.<BOP> | O00628 |
O15393 | TMPS2_HUMAN | Transmembrane protease serine 2 catalytic chain | Homo | <M><A><L><N><S><G><S><P><P><A><I><G><P><Y><Y><E><N><H><G><Y><Q><P><E><N><P><Y><P><A><Q><P><T><V><V><P><T><V><Y><E><V><H><P><A><Q><Y><Y><P><S><P><V><P><Q><Y><A><P><R><V><L><T><Q><A><S><N><P><V><V><C><T><Q><P><K><S><P><S><G><T><V><C><T><S><K><T><K><K><A><L><C><I><T><L><T><L><G><T><F><L><V><G><A><A><L><A><A><G><L><L><W><K... | (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry . Upon SARS-CoV-2 infection, in... | O15393 |
Q8IXB3 | TARG1_HUMAN | Tumor suppressor candidate 5 | Homo | <M><A><H><P><V><Q><S><E><F><P><S><A><Q><E><P><G><S><A><A><F><L><D><L><P><E><M><E><I><L><L><T><K><A><E><N><K><D><D><K><T><L><N><L><S><K><T><L><S><G><P><L><D><L><E><Q><N><S><Q><G><L><P><F><K><A><I><S><E><G><H><L><E><A><P><L><P><R><S><P><S><R><A><S><S><R><R><A><S><S><I><A><T><T><S><Y><A><Q><D><Q><E><A><P><R><D><Y><L><I><L... | Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.<BOP> | Q8IXB3 |
P32119 | PRDX2_HUMAN | Thioredoxin-dependent peroxiredoxin 2 | Homo | <M><A><S><G><N><A><R><I><G><K><P><A><P><D><F><K><A><T><A><V><V><D><G><A><F><K><E><V><K><L><S><D><Y><K><G><K><Y><V><V><L><F><F><Y><P><L><D><F><T><F><V><C><P><T><E><I><I><A><F><S><N><R><A><E><D><F><R><K><L><G><C><E><V><L><G><V><S><V><D><S><Q><F><T><H><L><A><W><I><N><T><P><R><K><E><G><G><L><G><P><L><N><I><P><L><L><A><D><V... | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling c... | P32119 |
Q8N5A5 | ZGPAT_HUMAN | Zinc finger and G patch domain-containing protein | Homo | <M><D><E><E><S><L><E><S><A><L><Q><T><Y><R><A><Q><L><Q><Q><V><E><L><A><L><G><A><G><L><D><S><S><E><Q><A><D><L><R><Q><L><Q><G><D><L><K><E><L><I><E><L><T><E><A><S><L><V><S><V><R><K><S><S><L><L><A><A><L><D><E><E><R><P><G><R><Q><E><D><A><E><Y><Q><A><F><R><E><A><I><T><E><A><V><E><A><P><A><A><A><R><G><S><G><S><E><T><V><P><K><A... | Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.<BOP> | Q8N5A5 |
O95631 | NET1_HUMAN | Epididymis tissue protein Li 131P | Homo | <M><M><R><A><V><W><E><A><L><A><A><L><A><A><V><A><C><L><V><G><A><V><R><G><G><P><G><L><S><M><F><A><G><Q><A><A><Q><P><D><P><C><S><D><E><N><G><H><P><R><R><C><I><P><D><F><V><N><A><A><F><G><K><D><V><R><V><S><S><T><C><G><R><P><P><A><R><Y><C><V><V><S><E><R><G><E><E><R><L><R><S><C><H><L><C><N><A><S><D><P><K><K><A><H><P><P><A><F... | Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubul... | O95631 |
P17024 | ZNF20_HUMAN | Zinc finger protein KOX13 | Homo | <M><M><F><Q><D><S><V><A><F><E><D><V><A><V><S><F><T><Q><E><E><W><A><L><L><D><P><S><Q><K><N><L><Y><R><D><V><M><Q><E><T><F><K><N><L><T><S><V><G><K><T><W><K><V><Q><N><I><E><D><E><Y><K><N><P><R><R><N><L><S><L><M><R><E><K><L><C><E><S><K><E><S><H><H><C><G><E><S><F><N><Q><I><A><D><D><M><L><N><R><K><T><L><P><G><I><T><P><C><E><S... | May be involved in transcriptional regulation.<BOP> | P17024 |
O00217 | NDUS8_HUMAN | TYKY subunit | Homo | <M><R><C><L><T><T><P><M><L><L><R><A><L><A><Q><A><A><R><A><G><P><P><G><G><R><S><L><H><S><S><A><V><A><A><T><Y><K><Y><V><N><M><Q><D><P><E><M><D><M><K><S><V><T><D><R><A><A><R><T><L><L><W><T><E><L><F><R><G><L><G><M><T><L><S><Y><L><F><R><E><P><A><T><I><N><Y><P><F><E><K><G><P><L><S><P><R><F><R><G><E><H><A><L><R><R><Y><P><S><G... | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity and assembly of complex I .<BOP> | O00217 |
A6NGE7 | URAD_HUMAN | Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase | Homo | <M><D><I><E><K><V><N><S><M><D><L><G><E><F><V><D><V><F><G><N><A><T><E><R><C><P><L><I><A><A><A><V><W><S><Q><R><P><F><S><D><L><E><D><L><E><K><H><F><F><A><F><I><D><A><L><A><Q><S><G><Q><E><G><I><L><R><C><H><P><D><L><A><G><S><E><L><Q><R><G><T><L><T><A><E><S><Q><R><E><Q><S><G><A><G><L><R><S><L><G><A><D><E><R><L><R><L><A><E><L... | Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.<BOP> | A6NGE7 |
Q9NQQ7 | S35C2_HUMAN | Ovarian cancer-overexpressed gene 1 protein | Homo | <M><G><R><W><A><L><D><V><A><F><L><W><K><A><V><L><T><L><G><L><V><L><L><Y><Y><C><F><S><I><G><I><T><F><Y><N><K><W><L><T><K><S><F><H><F><P><L><F><M><T><M><L><H><L><A><V><I><F><L><F><S><A><L><S><R><A><L><V><Q><C><S><S><H><R><A><R><V><V><L><S><W><A><D><Y><L><R><R><V><A><P><T><A><L><A><T><A><L><D><V><G><L><S><N><W><S><F><L><Y... | May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.<BOP> | Q9NQQ7 |
Q9Y5J3 | HEY1_HUMAN | Hairy-related transcription factor 1 | Homo | <M><K><R><A><H><P><E><Y><S><S><S><D><S><E><L><D><E><T><I><E><V><E><K><E><S><A><D><E><N><G><N><L><S><S><A><L><G><S><M><S><P><T><T><S><S><Q><I><L><A><R><K><R><R><R><G><I><I><E><K><R><R><R><D><R><I><N><N><S><L><S><E><L><R><R><L><V><P><S><A><F><E><K><Q><G><S><A><K><L><E><K><A><E><I><L><Q><M><T><V><D><H><L><K><M><L><H><T><A... | Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' . Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve an... | Q9Y5J3 |
Q16134 | ETFD_HUMAN | Electron-transferring-flavoprotein dehydrogenase | Homo | <M><L><V><P><L><A><K><L><S><C><L><A><Y><Q><C><F><H><A><L><K><I><K><K><N><Y><L><P><L><C><A><T><R><W><S><S><T><S><T><V><P><R><I><T><T><H><Y><T><I><Y><P><R><D><K><D><K><R><W><E><G><V><N><M><E><R><F><A><E><E><A><D><V><V><I><V><G><A><G><P><A><G><L><S><A><A><V><R><L><K><Q><L><A><V><A><H><E><K><D><I><R><V><C><L><V><E><K><A><A... | Accepts electrons from ETF and reduces ubiquinone.<BOP> | Q16134 |
Q8IYY4 | DZI1L_HUMAN | DAZ-interacting zinc finger protein 1-like | Homo | <M><Q><S><P><A><A><T><A><E><G><L><S><G><P><L><F><G><A><Y><T><F><P><T><F><K><F><Q><P><R><H><D><S><M><D><W><R><R><I><S><T><L><D><V><D><R><V><A><R><E><L><D><V><A><T><L><Q><E><N><I><A><G><I><T><F><C><N><L><D><R><E><V><C><S><R><C><G><Q><P><V><D><P><A><L><L><K><V><L><R><L><A><Q><L><I><I><E><Y><L><L><H><C><Q><D><C><L><S><A><S... | Involved in primary cilium formation . Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane .<BOP> | Q8IYY4 |
P17035 | ZNF28_HUMAN | Zinc finger protein KOX24 | Homo | <M><A><L><P><Q><G><L><L><T><F><R><D><V><A><I><E><F><S><Q><E><E><W><K><C><L><D><P><A><Q><R><T><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><D><I><S><S><K><C><M><M><K><T><F><F><S><T><G><Q><G><N><T><E><A><F><H><T><G><T><L><Q><R><Q><A><S><H><H><I><G><D><F><C><F><Q><K><I><E><K><D><I><H><G><F><Q><F><Q><W><K><E><D><E><T><N... | May be involved in transcriptional regulation.<BOP> | P17035 |
Q4G0Z9 | MCMD2_HUMAN | Minichromosome maintenance domain-containing protein 2 | Homo | <M><S><N><L><K><M><K><E><A><A><L><I><Y><L><D><R><S><G><G><L><Q><K><F><I><D><D><C><K><Y><Y><N><D><S><K><Q><S><Y><A><V><Y><R><F><K><I><L><I><N><P><S><D><V><V><E><L><D><A><E><L><G><N><H><I><L><H><Q><P><L><K><A><A><E><V><F><Q><S><V><C><F><I><A><V><K><T><L><S><L><I><G><Q><L><Q><T><E><T><Q><I><N><I><V><L><K><L><T><H><L><P><P... | Plays an important role in meiotic recombination and associated DNA double-strand break repair.<BOP> | Q4G0Z9 |
Q9BWM7 | SFXN3_HUMAN | Sideroflexin-3 | Homo | <M><G><E><L><P><L><D><I><N><I><Q><E><P><R><W><D><Q><S><T><F><L><G><R><A><R><H><F><F><T><V><T><D><P><R><N><L><L><L><S><G><A><Q><L><E><A><S><R><N><I><V><Q><N><Y><R><A><G><V><V><T><P><G><I><T><E><D><Q><L><W><R><A><K><Y><V><Y><D><S><A><F><H><P><D><T><G><E><K><V><V><L><I><G><R><M><S><A><Q><V><P><M><N><M><T><I><T><G><C><M><L... | Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway . Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors .<BOP> | Q9BWM7 |
Q7Z2Q7 | LRR70_HUMAN | Synleurin | Homo | <M><C><G><L><Q><F><S><L><P><C><L><R><L><F><L><V><V><T><C><Y><L><L><L><L><L><H><K><E><I><L><G><C><S><S><V><C><Q><L><C><T><G><R><Q><I><N><C><R><N><L><G><L><S><S><I><P><K><N><F><P><E><S><T><V><F><L><Y><L><T><G><N><N><I><S><Y><I><N><E><S><E><L><T><G><L><H><S><L><V><A><L><Y><L><D><N><S><N><I><L><Y><V><Y><P><K><A><F><V><Q><L... | Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS).<BOP> | Q7Z2Q7 |
Q9UHE8 | STEA1_HUMAN | Six-transmembrane epithelial antigen of prostate 1 | Homo | <M><E><S><R><K><D><I><T><N><Q><E><E><L><W><K><M><K><P><R><R><N><L><E><E><D><D><Y><L><H><K><D><T><G><E><T><S><M><L><K><R><P><V><L><L><H><L><H><Q><T><A><H><A><D><E><F><D><C><P><S><E><L><Q><H><T><Q><E><L><F><P><Q><W><H><L><P><I><K><I><A><A><I><I><A><S><L><T><F><L><Y><T><L><L><R><E><V><I><H><P><L><A><T><S><H><Q><Q><Y><F><Y... | Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.<BOP> | Q9UHE8 |
P49590 | SYHM_HUMAN | Histidyl-tRNA synthetase | Homo | <M><P><L><L><G><L><L><P><R><R><A><W><A><S><L><L><S><Q><L><L><R><P><P><C><A><S><C><T><G><A><V><R><C><Q><S><Q><V><A><E><A><V><L><T><S><Q><L><K><A><H><Q><E><K><P><N><F><I><I><K><T><P><K><G><T><R><D><L><S><P><Q><H><M><V><V><R><E><K><I><L><D><L><V><I><S><C><F><K><R><H><G><A><K><G><M><D><T><P><A><F><E><L><K><E><T><L><T><E><K... | Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP).<BOP> | P49590 |
P49703 | ARL4D_HUMAN | ADP-ribosylation factor-like protein 4L | Homo | <M><G><N><H><L><T><E><M><A><P><T><A><S><S><F><L><P><H><F><Q><A><L><H><V><V><V><I><G><L><D><S><A><G><K><T><S><L><L><Y><R><L><K><F><K><E><F><V><Q><S><V><P><T><K><G><F><N><T><E><K><I><R><V><P><L><G><G><S><R><G><I><T><F><Q><V><W><D><V><G><G><Q><E><K><L><R><P><L><W><R><S><Y><T><R><R><T><D><G><L><V><F><V><V><D><A><A><E><A><E... | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subun... | P49703 |
Q8IUZ0 | LRC49_HUMAN | Tubulin polyglutamylase complex subunit 4 | Homo | <M><I><P><G><K><Y><R><S><V><S><G><R><A><A><N><N><V><N><C><G><L><H><L><V><I><Q><T><S><S><L><P><E><K><N><K><V><E><F><K><L><N><K><D><T><S><S><F><P><G><R><L><L><Q><H><D><L><E><R><N><Y><S><S><R><Q><G><D><H><I><N><L><V><S><S><S><L><S><S><F><P><I><L><Q><R><S><S><E><E><K><I><L><Y><S><D><R><L><S><L><E><R><Q><K><L><T><V><C><P><I... | Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility.<BOP> | Q8IUZ0 |
Q7Z412 | PEX26_HUMAN | Peroxin-26 | Homo | <M><K><S><D><S><S><T><S><A><A><P><L><R><G><L><G><G><P><L><R><S><S><E><P><V><R><A><V><P><A><R><A><P><A><V><D><L><L><E><E><A><A><D><L><L><V><V><H><L><D><F><R><A><A><L><E><T><C><E><R><A><W><Q><S><L><A><N><H><A><V><A><E><E><P><A><G><T><S><L><E><V><K><C><S><L><C><V><V><G><I><Q><A><L><A><E><M><D><R><W><Q><E><V><L><S><W><V><L... | Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins w... | Q7Z412 |
Q01650 | LAT1_HUMAN | y+ system cationic amino acid transporter | Homo | <M><A><G><A><G><P><K><R><R><A><L><A><A><P><A><A><E><E><K><E><E><A><R><E><K><M><L><A><A><K><S><A><D><G><S><A><P><A><G><E><G><E><G><V><T><L><Q><R><N><I><T><L><L><N><G><V><A><I><I><V><G><T><I><I><G><S><G><I><F><V><T><P><T><G><V><L><K><E><A><G><S><P><G><L><A><L><V><V><W><A><A><C><G><V><F><S><I><V><G><A><L><C><Y><A><E><L><G... | (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.<BOP> | Q01650 |
Q13489 | BIRC3_HUMAN | TNFR2-TRAF-signaling complex protein 1 | Homo | <M><N><I><V><E><N><S><I><F><L><S><N><L><M><K><S><A><N><T><F><E><L><K><Y><D><L><S><C><E><L><Y><R><M><S><T><Y><S><T><F><P><A><G><V><P><V><S><E><R><S><L><A><R><A><G><F><Y><Y><T><G><V><N><D><K><V><K><C><F><C><C><G><L><M><L><D><N><W><K><R><G><D><S><P><T><E><K><H><K><K><L><Y><P><S><C><R><F><V><Q><S><L><N><S><V><N><N><L><E><A... | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonica... | Q13489 |
A0JD37 | TRDV3_HUMAN | T cell receptor delta variable 3 | Homo | <M><I><L><T><V><G><F><S><F><L><F><F><Y><R><G><T><L><C><D><K><V><T><Q><S><S><P><D><Q><T><V><A><S><G><S><E><V><V><L><L><C><T><Y><D><T><V><Y><S><N><P><D><L><F><W><Y><R><I><R><P><D><Y><S><F><Q><F><V><F><Y><G><D><N><S><R><S><E><G><A><D><F><T><Q><G><R><F><S><V><K><H><I><L><T><Q><K><A><F><H><L><V><I><S><P><V><R><T><E><D><S><A... | V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids present... | A0JD37 |
Q9BQT8 | ODC_HUMAN | Solute carrier family 25 member 21 | Homo | <M><S><A><K><P><E><V><S><L><V><R><E><A><S><R><Q><I><V><A><G><G><S><A><G><L><V><E><I><C><L><M><H><P><L><D><V><V><K><T><R><F><Q><I><Q><R><C><A><T><D><P><N><S><Y><K><S><L><V><D><S><F><R><M><I><F><Q><M><E><G><L><F><G><F><Y><K><G><I><L><P><P><I><L><A><E><T><P><K><R><A><V><K><F><F><T><F><E><Q><Y><K><K><L><L><G><Y><V><S><L><S... | Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism . Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedio... | Q9BQT8 |
Q4G0W2 | DUS28_HUMAN | Dual specificity phosphatase 28 | Homo | <M><G><P><A><E><A><G><R><R><G><A><A><S><P><V><P><P><P><L><V><R><V><A><P><S><L><F><L><G><S><A><R><A><A><G><A><E><E><Q><L><A><R><A><G><V><T><L><C><V><N><V><S><R><Q><Q><P><G><P><R><A><P><G><V><A><E><L><R><V><P><V><F><D><D><P><A><E><D><L><L><A><H><L><E><P><T><C><A><A><M><E><A><A><V><R><A><G><G><A><C><L><V><Y><C><K><N><G><R... | Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) . Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine . The poor activity with phosphotyrosine may be due to... | Q4G0W2 |
Q9H321 | VCX3B_HUMAN | Variably charged protein X-C | Homo | <M><S><P><K><P><R><A><S><G><P><P><A><K><A><K><E><A><G><K><R><K><S><S><S><Q><P><S><P><S><D><P><K><K><K><T><T><K><V><A><K><K><G><K><A><V><R><R><G><R><R><G><K><K><G><A><A><T><K><M><A><A><V><T><A><P><E><A><E><S><G><P><A><A><P><G><P><S><D><Q><P><S><Q><E><L><P><Q><H><E><L><P><P><E><E><P><V><S><E><G><T><Q><H><D><P><L><S><Q><E... | May mediate a process in spermatogenesis or may play a role in sex ratio distortion.<BOP> | Q9H321 |
Q96G21 | IMP4_HUMAN | Brix domain-containing protein 4 | Homo | <M><L><R><R><E><A><R><L><R><R><E><Y><L><Y><R><K><A><R><E><E><A><Q><R><S><A><Q><E><R><K><E><R><L><R><R><A><L><E><E><N><R><L><I><P><T><E><L><R><R><E><A><L><A><L><Q><G><S><L><E><F><D><D><A><G><G><E><G><V><T><S><H><V><D><D><E><Y><R><W><A><G><V><E><D><P><K><V><M><I><T><T><S><R><D><P><S><S><R><L><K><M><F><A><K><E><L><K><L><V... | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.<BOP> | Q96G21 |
Q9NQZ6 | ZC4H2_HUMAN | Hepatocellular carcinoma-associated antigen 127 | Homo | <M><A><D><E><Q><E><I><M><C><K><L><E><S><I><K><E><I><R><N><K><T><L><Q><M><E><K><I><K><A><R><L><K><A><E><F><E><A><L><E><S><E><E><R><H><L><K><E><Y><K><Q><E><M><D><L><L><L><Q><E><K><M><A><H><V><E><E><L><R><L><I><H><A><D><I><N><V><M><E><N><T><I><K><Q><S><E><N><D><L><N><K><L><L><E><S><T><R><R><L><H><D><E><Y><K><P><L><K><E><H... | Plays a role in interneurons differentiation . Involved in neuronal development and in neuromuscular junction formation.<BOP> | Q9NQZ6 |
Q9NP94 | S39A2_HUMAN | Zrt- and Irt-like protein 2 | Homo | <M><E><Q><L><L><G><I><K><L><G><C><L><F><A><L><L><A><L><T><L><G><C><G><L><T><P><I><C><F><K><W><F><Q><I><D><A><A><R><G><H><H><R><L><V><L><R><L><L><G><C><I><S><A><G><V><F><L><G><A><G><F><M><H><M><T><A><E><A><L><E><E><I><E><S><Q><I><Q><K><F><M><V><Q><N><R><S><A><S><E><R><N><S><S><G><D><A><D><S><A><H><M><E><Y><P><Y><G><E><L... | Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.<BOP> | Q9NP94 |
Q8N806 | UBR7_HUMAN | RING-type E3 ubiquitin transferase UBR7 | Homo | <M><A><G><A><E><G><A><A><G><R><Q><S><E><L><E><P><V><V><S><L><V><D><V><L><E><E><D><E><E><L><E><N><E><A><C><A><V><L><G><G><S><D><S><E><K><C><S><Y><S><Q><G><S><V><K><R><Q><A><L><Y><A><C><S><T><C><T><P><E><G><E><E><P><A><G><I><C><L><A><C><S><Y><E><C><H><G><S><H><K><L><F><E><L><Y><T><K><R><N><F><R><C><D><C><G><N><S><K><F><K... | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.<BOP> | Q8N806 |
P31268 | HXA7_HUMAN | Homeobox protein Hox-1A | Homo | <M><S><S><S><Y><Y><V><N><A><L><F><S><K><Y><T><A><G><A><S><L><F><Q><N><A><E><P><T><S><C><S><F><A><P><N><S><Q><R><S><G><Y><G><A><G><A><G><A><F><A><S><T><V><P><G><L><Y><N><V><N><S><P><L><Y><Q><S><P><F><A><S><G><Y><G><L><G><A><D><A><Y><G><N><L><P><C><A><S><Y><D><Q><N><I><P><G><L><C><S><D><L><A><K><G><A><C><D><K><T><D><E><G... | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP> | P31268 |
P27448 | MARK3_HUMAN | Serine/threonine-protein kinase p78 | Homo | <M><S><T><R><T><P><L><P><T><V><N><E><R><D><T><E><N><H><T><S><H><G><D><G><R><Q><E><V><T><S><R><T><S><R><S><G><A><R><C><R><N><S><I><A><S><C><A><D><E><Q><P><H><I><G><N><Y><R><L><L><K><T><I><G><K><G><N><F><A><K><V><K><L><A><R><H><I><L><T><G><R><E><V><A><I><K><I><I><D><K><T><Q><L><N><P><T><S><L><Q><K><L><F><R><E><V><R><I><M... | Serine/threonine-protein kinase . Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU . Phosphorylates CDC25C on 'Ser-216' . Regulates localization and activity of some histone deacetylases by mediating phosphorylation... | P27448 |
Q9NPC1 | LT4R2_HUMAN | Seven transmembrane receptor BLTR2 | Homo | <M><S><V><C><Y><R><P><P><G><N><E><T><L><L><S><W><K><T><S><R><A><T><G><T><A><F><L><L><L><A><A><L><L><G><L><P><G><N><G><F><V><V><W><S><L><A><G><W><R><P><A><R><G><R><P><L><A><A><T><L><V><L><H><L><A><L><A><D><G><A><V><L><L><L><T><P><L><F><V><A><F><L><T><R><Q><A><W><P><L><G><Q><A><G><C><K><A><V><Y><Y><V><C><A><L><S><M><Y><A... | Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.<BOP> | Q9NPC1 |
P56180 | TPTE_HUMAN | Tumor antigen BJ-HCC-5 | Homo | <M><N><E><S><P><D><P><T><D><L><A><G><V><I><I><E><L><G><P><N><D><S><P><Q><T><S><E><F><K><G><A><T><E><E><A><P><A><K><E><S><P><H><T><S><E><F><K><G><A><A><R><V><S><P><I><S><E><S><V><L><A><R><L><S><K><F><E><V><E><D><A><E><N><V><A><S><Y><D><S><K><I><K><K><I><V><H><S><I><V><S><S><F><A><F><G><L><F><G><V><F><L><V><L><L><D><V><T... | Could be involved in signal transduction.<BOP> | P56180 |
Q92786 | PROX1_HUMAN | Homeobox prospero-like protein PROX1 | Homo | <M><P><D><H><D><S><T><A><L><L><S><R><Q><T><K><R><R><R><V><D><I><G><V><K><R><T><V><G><T><A><S><A><F><F><A><K><A><R><A><T><F><F><S><A><M><N><P><Q><G><S><E><Q><D><V><E><Y><S><V><V><Q><H><A><D><G><E><K><S><N><V><L><R><K><L><L><K><R><A><N><S><Y><E><D><A><M><M><P><F><P><G><A><T><I><I><S><Q><L><L><K><N><N><M><N><K><N><G><G><T... | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye l... | Q92786 |
Q6UX39 | AMTN_HUMAN | Amelotin | Homo | <M><R><S><T><I><L><L><F><C><L><L><G><S><T><R><S><L><P><Q><L><K><P><A><L><G><L><P><P><T><K><L><A><P><D><Q><G><T><L><P><N><Q><Q><Q><S><N><Q><V><F><P><S><L><S><L><I><P><L><T><Q><M><L><T><L><G><P><D><L><H><L><L><N><P><A><A><G><M><T><P><G><T><Q><T><H><P><L><T><L><G><G><L><N><V><Q><Q><Q><L><H><P><H><V><L><P><I><F><V><T><Q><L... | Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.<BOP> | Q6UX39 |
Q14192 | FHL2_HUMAN | Skeletal muscle LIM-protein 3 | Homo | <M><T><E><R><F><D><C><H><H><C><N><E><S><L><F><G><K><K><Y><I><L><R><E><E><S><P><Y><C><V><V><C><F><E><T><L><F><A><N><T><C><E><E><C><G><K><P><I><G><C><D><C><K><D><L><S><Y><K><D><R><H><W><H><E><A><C><F><H><C><S><Q><C><R><N><S><L><V><D><K><P><F><A><A><K><E><D><Q><L><L><C><T><D><C><Y><S><N><E><Y><S><S><K><C><Q><E><C><K><K><T... | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 an... | Q14192 |
Q6PIL6 | KCIP4_HUMAN | Potassium channel-interacting protein 4 | Homo | <M><N><V><R><R><V><E><S><I><S><A><Q><L><E><E><A><S><S><T><G><G><F><L><Y><A><Q><N><S><T><K><R><S><I><K><E><R><L><M><K><L><L><P><C><S><A><A><K><T><S><S><P><A><I><Q><N><S><V><E><D><E><L><E><M><A><T><V><R><H><R><P><E><A><L><E><L><L><E><A><Q><S><K><F><T><K><K><E><L><Q><I><L><Y><R><G><F><K><N><E><C><P><S><G><V><V><N><E><E><T... | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner . Modulates KCND3/Kv4.3 currents . Isoform 4 does not increase KCND2 expr... | Q6PIL6 |
P34982 | OR1D2_HUMAN | Olfactory receptor-like protein HGMP07E | Homo | <M><D><G><G><N><Q><S><E><G><S><E><F><L><L><L><G><M><S><E><S><P><E><Q><Q><R><I><L><F><W><M><F><L><S><M><Y><L><V><T><V><V><G><N><V><L><I><I><L><A><I><S><S><D><S><R><L><H><T><P><V><Y><F><F><L><A><N><L><S><F><T><D><L><F><F><V><T><N><T><I><P><K><M><L><V><N><L><Q><S><H><N><K><A><I><S><Y><A><G><C><L><T><Q><L><Y><F><L><V><S><L... | Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.<BOP> | P34982 |
O00574 | CXCR6_HUMAN | G-protein coupled receptor bonzo | Homo | <M><A><E><H><D><Y><H><E><D><Y><G><F><S><S><F><N><D><S><S><Q><E><E><H><Q><D><F><L><Q><F><S><K><V><F><L><P><C><M><Y><L><V><V><F><V><C><G><L><V><G><N><S><L><V><L><V><I><S><I><F><Y><H><K><L><Q><S><L><T><D><V><F><L><V><N><L><P><L><A><D><L><V><F><V><C><T><L><P><F><W><A><Y><A><G><I><H><E><W><V><F><G><Q><V><M><C><K><S><L><L><G... | Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.<BOP> | O00574 |
Q9NYQ3 | HAOX2_HUMAN | Long-chain L-2-hydroxy acid oxidase | Homo | <M><S><L><V><C><L><T><D><F><Q><A><H><A><R><E><Q><L><S><K><S><T><R><D><F><I><E><G><G><A><D><D><S><I><T><R><D><D><N><I><A><A><F><K><R><I><R><L><R><P><R><Y><L><R><D><V><S><E><V><D><T><R><T><T><I><Q><G><E><E><I><S><A><P><I><C><I><A><P><T><G><F><H><C><L><V><W><P><D><G><E><M><S><T><A><R><A><A><Q><A><A><G><I><C><Y><I><T><S><T... | Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the correspondong 2-oxoacids . Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (Probable). Active in vitro with the ... | Q9NYQ3 |
O95407 | TNF6B_HUMAN | M68 | Homo | <M><R><A><L><E><G><P><G><L><S><L><L><C><L><V><L><A><L><P><A><L><L><P><V><P><A><V><R><G><V><A><E><T><P><T><Y><P><W><R><D><A><E><T><G><E><R><L><V><C><A><Q><C><P><P><G><T><F><V><Q><R><P><C><R><R><D><S><P><T><T><C><G><P><C><P><P><R><H><Y><T><Q><F><W><N><Y><L><E><R><C><R><Y><C><N><V><L><C><G><E><R><E><E><E><A><R><A><C><H><A... | Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<BOP> | O95407 |
A8MUV8 | ZN727_HUMAN | Zinc finger protein 727 pseudogene | Homo | <M><R><V><L><T><F><R><D><V><A><V><E><F><S><P><E><E><W><E><C><L><D><S><A><Q><Q><R><L><Y><R><D><V><M><L><E><N><Y><G><N><L><F><S><L><G><L><A><I><F><K><P><D><L><I><T><Y><L><E><Q><R><K><E><P><W><N><A><R><R><Q><K><T><V><A><K><H><P><A><G><S><L><H><F><T><A><E><I><L><L><E><H><D><I><N><D><S><F><Q><K><V><I><L><R><K><S><G><S><C><D... | May be involved in transcriptional regulation.<BOP> | A8MUV8 |
Q9Y6A9 | SPCS1_HUMAN | Microsomal signal peptidase 12 kDa subunit | Homo | <M><A><R><G><G><D><T><G><C><T><G><P><S><E><T><S><A><S><G><A><A><A><I><A><L><P><G><L><E><G><P><A><T><D><A><Q><C><Q><T><L><P><L><T><V><L><K><S><R><S><P><S><P><R><S><L><P><P><A><L><S><C><P><P><P><Q><P><A><M><L><E><H><L><S><S><L><P><T><Q><M><D><Y><K><G><Q><K><L><A><E><Q><M><F><Q><G><I><I><L><F><S><A><I><V><G><F><I><Y><G><Y... | (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV) . Plays a k... | Q9Y6A9 |
P08912 | ACM5_HUMAN | Muscarinic acetylcholine receptor M5 | Homo | <M><E><G><D><S><Y><H><N><A><T><T><V><N><G><T><P><V><N><H><Q><P><L><E><R><H><R><L><W><E><V><I><T><I><A><A><V><T><A><V><V><S><L><I><T><I><V><G><N><V><L><V><M><I><S><F><K><V><N><S><Q><L><K><T><V><N><N><Y><Y><L><L><S><L><A><C><A><D><L><I><I><G><I><F><S><M><N><L><Y><T><T><Y><I><L><M><G><R><W><A><L><G><S><L><A><C><D><L><W><L... | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<BOP> | P08912 |
Q9BVL2 | NUP58_HUMAN | Nucleoporin-like protein 1 | Homo | <M><S><T><G><F><S><F><G><S><G><T><L><G><S><T><T><V><A><A><G><G><T><S><T><G><G><V><F><S><F><G><T><G><A><S><S><N><P><S><V><G><L><N><F><G><N><L><G><S><T><S><T><P><A><T><T><S><A><P><S><S><G><F><G><T><G><L><F><G><S><K><P><A><T><G><F><T><L><G><G><T><N><T><G><I><A><T><T><I><T><T><G><L><T><L><G><T><P><A><T><T><S><A><A><T><T><G... | Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.<BOP> | Q9BVL2 |
P09603 | CSF1_HUMAN | Processed macrophage colony-stimulating factor 1 | Homo | <M><T><A><P><G><A><A><G><R><C><P><P><T><T><W><L><G><S><L><L><L><L><V><C><L><L><A><S><R><S><I><T><E><E><V><S><E><Y><C><S><H><M><I><G><S><G><H><L><Q><S><L><Q><R><L><I><D><S><Q><M><E><T><S><C><Q><I><T><F><E><F><V><D><Q><E><Q><L><K><D><P><V><C><Y><L><K><K><A><F><L><L><V><Q><D><I><M><E><D><T><M><R><F><R><D><N><T><P><N><A><I... | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and i... | P09603 |
A2A288 | ZC12D_HUMAN | p34 | Homo | <M><E><H><P><S><K><M><E><F><F><Q><K><L><G><Y><D><R><E><D><V><L><R><V><L><G><K><L><G><E><G><A><L><V><N><D><V><L><Q><E><L><I><R><T><G><S><R><P><G><A><L><E><H><P><A><A><P><R><L><V><P><R><G><S><C><G><V><P><D><S><A><Q><R><G><P><G><T><A><L><E><E><D><F><R><T><L><A><S><S><L><R><P><I><V><I><D><G><S><N><V><A><M><S><H><G><N><K><E... | May regulate cell growth likely by suppressing RB1 phosphorylation . May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages . Serve as a tumor suppressor in certain leukemia cells . Ove... | A2A288 |
Q8TBZ6 | TM10A_HUMAN | tRNA (guanine(9)-N(1))-methyltransferase TRMT10A | Homo | <M><S><S><E><M><L><P><A><F><I><E><T><S><N><V><D><K><K><Q><G><I><N><E><D><Q><E><E><S><Q><K><P><R><L><G><E><G><C><E><P><I><S><K><R><Q><M><K><K><L><I><K><Q><K><Q><W><E><E><Q><R><E><L><R><K><Q><K><R><K><E><K><R><K><R><K><K><L><E><R><Q><C><Q><M><E><P><N><S><D><G><H><D><R><K><R><V><R><R><D><V><V><H><S><T><L><R><L><I><I><D><C... | S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs . Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs .<BOP> | Q8TBZ6 |
O14633 | LCE2B_HUMAN | Small proline-rich-like epidermal differentiation complex protein 1B | Homo | <M><S><C><Q><Q><N><Q><Q><Q><C><Q><P><P><P><K><C><P><P><K><C><T><P><K><C><P><P><K><C><P><P><K><C><L><P><Q><C><P><A><P><C><S><P><A><V><S><S><C><C><G><P><I><S><G><G><C><C><G><P><S><S><G><G><C><C><N><S><G><A><G><G><C><C><L><S><H><H><R><P><R><L><F><H><R><R><R><H><Q><S><P><D><C><C><E><S><E><P><S><G><G><S><G><C><C><H><S><S><G... | Precursors of the cornified envelope of the stratum corneum.<BOP> | O14633 |
Q7RTV3 | ZN367_HUMAN | C2H2 zinc finger protein ZFF29 | Homo | <M><I><R><G><F><E><A><P><M><A><E><N><P><P><P><P><P><P><P><V><I><F><C><H><D><S><P><K><R><V><L><V><S><V><I><R><T><T><P><I><K><P><T><C><G><G><G><G><E><P><E><P><P><P><P><L><I><P><T><S><P><G><F><S><D><F><M><V><Y><P><W><R><W><G><E><N><A><H><N><V><T><L><S><P><G><A><A><G><A><A><A><S><A><A><L><P><A><A><A><A><A><E><H><S><G><L><R... | Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes.<BOP> | Q7RTV3 |
P07237 | PDIA1_HUMAN | p55 | Homo | <M><L><R><R><A><L><L><C><L><A><V><A><A><L><V><R><A><D><A><P><E><E><E><D><H><V><L><V><L><R><K><S><N><F><A><E><A><L><A><A><H><K><Y><L><L><V><E><F><Y><A><P><W><C><G><H><C><K><A><L><A><P><E><Y><A><K><A><A><G><K><L><K><A><E><G><S><E><I><R><L><A><K><V><D><A><T><E><E><S><D><L><A><Q><Q><Y><G><V><R><G><Y><P><T><I><K><F><F><R><N... | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrang... | P07237 |
O43189 | PHF1_HUMAN | Polycomb-like protein 1 | Homo | <M><A><Q><P><P><R><L><S><R><S><G><A><S><S><L><W><D><P><A><S><P><A><P><T><S><G><P><R><P><R><L><W><E><G><Q><D><V><L><A><R><W><T><D><G><L><L><Y><L><G><T><I><K><K><V><D><S><A><R><E><V><C><L><V><Q><F><E><D><D><S><Q><F><L><V><L><W><K><D><I><S><P><A><A><L><P><G><E><E><L><L><C><C><V><C><R><S><E><T><V><V><P><G><N><R><L><V><S><C... | Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however ... | O43189 |
Q99828 | CIB1_HUMAN | SNK-interacting protein 2-28 | Homo | <M><G><G><S><G><S><R><L><S><K><E><L><L><A><E><Y><Q><D><L><T><F><L><T><K><Q><E><I><L><L><A><H><R><R><F><C><E><L><L><P><Q><E><Q><R><S><V><E><S><S><L><R><A><Q><V><P><F><E><Q><I><L><S><L><P><E><L><K><A><N><P><F><K><E><R><I><C><R><V><F><S><T><S><P><A><K><D><S><L><S><F><E><D><F><L><D><L><L><S><V><F><S><D><T><A><T><P><D><I><K... | (Microbial infection) Involved in keratinocyte-intrinsic immunity to human beta-papillomaviruses (HPVs).<BOP> | Q99828 |
Q9Y6W6 | DUS10_HUMAN | Mitogen-activated protein kinase phosphatase 5 | Homo | <M><P><P><S><P><L><D><D><R><V><V><V><A><L><S><R><P><V><R><P><Q><D><L><N><L><C><L><D><S><S><Y><L><G><S><A><N><P><G><S><N><S><H><P><P><V><I><A><T><T><V><V><S><L><K><A><A><N><L><T><Y><M><P><S><S><S><G><S><A><R><S><L><N><C><G><C><S><S><A><S><C><C><T><V><A><T><Y><D><K><D><N><Q><A><Q><T><Q><A><I><A><A><G><T><T><T><T><A><I><G... | Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.<BOP> | Q9Y6W6 |
P40424 | PBX1_HUMAN | Homeobox protein PRL | Homo | <M><D><E><Q><P><R><L><M><H><S><H><A><G><V><G><M><A><G><H><P><G><L><S><Q><H><L><Q><D><G><A><G><G><T><E><G><E><G><G><R><K><Q><D><I><G><D><I><L><Q><Q><I><M><T><I><T><D><Q><S><L><D><E><A><Q><A><R><K><H><A><L><N><C><H><R><M><K><P><A><L><F><N><V><L><C><E><I><K><E><K><T><V><L><S><I><R><G><A><Q><E><E><E><P><T><D><P><Q><L><M><R... | As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.<BOP> | P40424 |
P21145 | MAL_HUMAN | T-lymphocyte maturation-associated protein | Homo | <M><A><P><A><A><A><T><G><G><S><T><L><P><S><G><F><S><V><F><T><T><L><P><D><L><L><F><I><F><E><F><I><F><G><G><L><V><W><I><L><V><A><S><S><L><V><P><W><P><L><V><Q><G><W><V><M><F><V><S><V><F><C><F><V><A><T><T><T><L><I><I><L><Y><I><I><G><A><H><G><G><E><T><S><W><V><T><L><D><A><A><Y><H><C><T><A><A><L><F><Y><L><S><A><S><V><L><E><A... | Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.<BOP> | P21145 |
O15304 | SIVA_HUMAN | CD27-binding protein | Homo | <M><P><K><R><S><C><P><F><A><D><V><A><P><L><Q><L><K><V><R><V><S><Q><R><E><L><S><R><G><V><C><A><E><R><Y><S><Q><E><V><F><E><K><T><K><R><L><L><F><L><G><A><Q><A><Y><L><D><H><V><W><D><E><G><C><A><V><V><H><L><P><E><S><P><K><P><G><P><T><G><A><P><R><A><A><R><G><Q><M><L><I><G><P><D><G><R><L><I><R><S><L><G><Q><A><S><E><A><D><P><S... | Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.<BOP> | O15304 |
O15231 | ZN185_HUMAN | P1-A | Homo | <M><S><I><S><A><L><G><G><R><T><K><G><K><P><L><P><P><G><E><E><E><R><N><N><V><L><K><Q><M><K><V><R><T><T><L><K><G><D><K><S><W><I><T><K><Q><D><E><S><E><G><R><T><I><E><L><P><S><G><R><S><R><A><T><S><F><S><S><A><G><E><V><P><K><P><R><P><P><S><T><R><A><P><T><G><Y><I><I><R><G><V><F><T><K><P><I><D><S><S><S><Q><P><Q><Q><Q><F><P><K... | May be involved in the regulation of cellular proliferation and/or differentiation.<BOP> | O15231 |
A6NDL8 | O6C68_HUMAN | Olfactory receptor 6C68 | Homo | <M><R><K><H><T><A><I><T><T><F><I><L><L><G><L><T><E><D><P><Q><L><Q><V><L><L><F><M><F><L><F><I><T><Y><M><L><S><V><T><G><K><L><T><I><I><A><L><T><M><L><D><P><H><L><K><T><P><M><Y><F><F><L><Q><N><L><S><F><L><E><I><S><F><T><A><T><C><V><P><R><F><L><Y><S><I><S><T><G><N><K><I><I><T><Y><N><A><C><V><I><Q><L><F><F><A><D><L><F><G><V... | Odorant receptor.<BOP> | A6NDL8 |
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