accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q6PGQ7
BORA_HUMAN
Protein aurora borealis
Homo
<M><G><D><V><K><E><S><K><M><Q><I><T><P><E><T><P><G><R><I><P><V><L><N><P><F><E><S><P><S><D><Y><S><N><L><H><E><Q><T><L><A><S><P><S><V><F><K><S><T><K><L><P><T><P><G><K><F><R><W><S><I><D><Q><L><A><V><I><N><P><V><E><I><D><P><E><D><I><H><R><Q><A><L><Y><L><S><H><S><R><I><D><K><D><V><E><D><K><R><Q><K><A><I><E><E><F><F><T><K><D><V><I><V><P><S><P><W><T><D><H><E><G><K><Q><L><S><Q><C><H><S><S><K><C><T><N><I><N><S><D><S><P><V><G><K><K><L><T><I><H><S><E><K><S><D><A><A><C><Q><T><L><L><S><L><P><V><D><F><N><L><E><N><I><L><G><D><Y><F><R><A><D><E><F><A><D><Q><S><P><G><N><L><S><S><S><S><L><R><R><K><L><F><L><D><G><N><G><S><I><S><D><S><L><P><S><A><S><P><G><S><P><H><S><G><V><Q><T><S><L><E><M><F><Y><S><I><D><L><S><P><V><K><C><R><S><P><L><Q><T><P><S><S><G><Q><F><S><S><S><P><I><Q><A><S><A><K><K><Y><S><L><G><S><I><T><S><P><S><P><I><S><S><P><T><F><S><P><I><E><F><Q><I><G><E><T><P><L><S><E><Q><R><K><F><T><V><H><S><P><D><A><S><S><G><T><N><S><N><G><I><T><N><P><C><I><R><S><P><Y><I><D><G><C><S><P><I><K><N><W><S><P><M><R><L><Q><M><Y><S><G><G><T><Q><Y><R><T><S><V><I><Q><I><P><F><T><L><E><T><Q><G><E><D><E><E><D><K><E><N><I><P><S><T><D><V><S><S><P><A><M><D><A><A><G><I><H><L><R><Q><F><S><N><E><A><S><T><H><G><T><H><L><V><V><T><A><M><S><V><T><Q><N><Q><S><S><A><S><E><K><E><L><A><L><L><Q><D><V><E><R><E><K><D><N><N><T><V><D><M><V><D><P><I><E><I><A><D><E><T><T><W><I><K><E><P><V><D><N><G><S><L><P><M><T><D><F><V><S><G><I><A><F><S><I><E><N><S><H><M><C><M><S><P><L><A><E><S><S><V><I><P><C><E><S><S><N><I><Q><M><D><S><G><Y><N><T><Q><N><C><G><S><N><I><M><D><T><V><G><A><E><S><Y><C><K><E><S><D><A><Q><T><C><E><V><E><S><K><S><Q><A><F><N><M><K><Q><D><H><T><T><Q><R><C><W><M><K><T><A><S><P><F><Q><C><S><S><P>
Required for the activation of AURKA at the onset of mitosis.<BOP>
Q6PGQ7
A0A0A0MS04
TVB67_HUMAN
Probable non-functional T cell receptor beta variable 6-7
Homo
<M><S><L><G><L><L><C><C><V><A><F><S><L><L><W><A><G><P><M><N><A><G><V><T><Q><T><P><K><F><H><V><L><K><T><G><Q><S><M><T><L><L><C><A><Q><D><M><N><H><E><Y><M><Y><R><Y><R><Q><D><P><G><K><G><L><R><L><I><Y><Y><S><V><A><A><A><L><T><D><K><G><E><V><P><N><G><Y><N><V><S><R><S><N><T><E><D><F><P><L><K><L><E><S><A><A><P><S><Q><T><S><V><Y><F><C><A><S><S><Y>
Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain . Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK
A0A0A0MS04
P23515
OMGP_HUMAN
Oligodendrocyte-myelin glycoprotein
Homo
<M><E><Y><Q><I><L><K><M><S><L><C><L><F><I><L><L><F><L><T><P><G><I><L><C><I><C><P><L><Q><C><I><C><T><E><R><H><R><H><V><D><C><S><G><R><N><L><S><T><L><P><S><G><L><Q><E><N><I><I><H><L><N><L><S><Y><N><H><F><T><D><L><H><N><Q><L><T><Q><Y><T><N><L><R><T><L><D><I><S><N><N><R><L><E><S><L><P><A><H><L><P><R><S><L><W><N><M><S><A><A><N><N><N><I><K><L><L><D><K><S><D><T><A><Y><Q><W><N><L><K><Y><L><D><V><S><K><N><M><L><E><K><V><V><L><I><K><N><T><L><R><S><L><E><V><L><N><L><S><S><N><K><L><W><T><V><P><T><N><M><P><S><K><L><H><I><V><D><L><S><N><N><S><L><T><Q><I><L><P><G><T><L><I><N><L><T><N><L><T><H><L><Y><L><H><N><N><K><F><T><F><I><P><D><Q><S><F><D><Q><L><F><Q><L><Q><E><I><T><L><Y><N><N><R><W><S><C><D><H><K><Q><N><I><T><Y><L><L><K><W><M><M><E><T><K><A><H><V><I><G><T><P><C><S><T><Q><I><S><S><L><K><E><H><N><M><Y><P><T><P><S><G><F><T><S><S><L><F><T><V><S><G><M><Q><T><V><D><T><I><N><S><L><S><V><V><T><Q><P><K><V><T><K><I><P><K><Q><Y><R><T><K><E><T><T><F><G><A><T><L><S><K><D><T><T><F><T><S><T><D><K><A><F><V><P><Y><P><E><D><T><S><T><E><T><I><N><S><H><E><A><A><A><A><T><L><T><I><H><L><Q><D><G><M><V><T><N><T><S><L><T><S><S><T><K><S><S><P><T><P><M><T><L><S><I><T><S><G><M><P><N><N><F><S><E><M><P><Q><Q><S><T><T><L><N><L><W><R><E><E><T><T><T><N><V><K><T><P><L><P><S><V><A><N><A><W><K><V><N><A><S><F><L><L><L><L><N><V><V><V><M><L><A><V>
Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.<BOP>
P23515
Q8NH01
O2T11_HUMAN
Olfactory receptor OR1-65
Homo
<M><T><N><T><S><S><S><D><F><T><L><L><G><L><L><V><N><S><E><A><A><G><I><V><F><T><V><I><L><A><V><F><L><G><A><V><T><A><N><L><V><M><I><F><L><I><Q><V><D><S><R><L><H><T><P><M><Y><F><L><L><S><Q><L><S><I><M><D><T><L><F><I><C><T><T><V><P><K><L><L><A><D><M><V><S><K><E><K><I><I><S><F><V><A><C><G><I><Q><I><F><L><Y><L><T><M><I><G><S><E><F><F><L><L><G><L><M><A><Y><D><C><Y><V><A><V><C><N><P><L><R><Y><P><V><L><M><N><R><K><K><C><L><L><L><A><A><G><A><W><F><G><G><S><L><D><G><F><L><L><T><P><I><T><M><N><V><P><Y><C><G><S><R><S><I><N><H><F><F><C><E><I><P><A><V><L><K><L><A><C><A><D><T><S><L><Y><E><T><L><M><Y><I><C><C><V><L><M><L><L><I><P><I><S><I><I><S><T><S><Y><S><L><I><L><L><T><I><H><R><M><P><S><A><E><G><R><K><K><A><F><T><T><C><S><S><H><L><T><V><V><S><I><F><Y><G><A><A><F><Y><T><Y><V><L><P><Q><S><F><H><T><P><E><Q><D><K><V><V><S><A><F><Y><T><I><V><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><I><G><A><F><K><K><V><F><A><C><C><S><S><A><Q><K><V><A><T><S><D><A>
Odorant receptor.<BOP>
Q8NH01
O15488
GLYG2_HUMAN
Glycogenin-2
Homo
<M><S><E><T><E><F><H><H><G><A><Q><A><G><L><E><L><L><R><S><S><N><S><P><T><S><A><S><Q><S><A><G><M><T><V><T><D><Q><A><F><V><T><L><A><T><N><D><I><Y><C><Q><G><A><L><V><L><G><Q><S><L><R><R><H><R><L><T><R><K><L><V><V><L><I><T><P><Q><V><S><S><L><L><R><V><I><L><S><K><V><F><D><E><V><I><E><V><N><L><I><D><S><A><D><Y><I><H><L><A><F><L><K><R><P><E><L><G><L><T><L><T><K><L><H><C><W><T><L><T><H><Y><S><K><C><V><F><L><D><A><D><T><L><V><L><S><N><V><D><E><L><F><D><R><G><E><F><S><A><A><P><D><P><G><W><P><D><C><F><N><S><G><V><F><V><F><Q><P><S><L><H><T><H><K><L><L><L><Q><H><A><M><E><H><G><S><F><D><G><A><D><Q><G><L><L><N><S><F><F><R><N><W><S><T><T><D><I><H><K><H><L><P><F><I><Y><N><L><S><S><N><T><M><Y><T><Y><S><P><A><F><K><Q><F><G><S><S><A><K><V><V><H><F><L><G><S><M><K><P><W><N><Y><K><Y><N><P><Q><S><G><S><V><L><E><Q><G><S><A><S><S><S><Q><H><Q><A><A><F><L><H><L><W><W><T><V><Y><Q><N><N><V><L><P><L><Y><K><S><V><Q><A><G><E><A><R><A><S><P><G><H><T><L><C><H><S><D><V><G><G><P><C><A><D><S><A><S><G><V><G><E><P><C><E><N><S><T><P><S><A><G><V><P><C><A><N><S><P><L><G><S><N><Q><P><A><Q><G><L><P><E><P><T><Q><I><V><D><E><T><L><S><L><P><E><G><R><R><S><E><D><M><I><A><C><P><E><T><E><T><P><A><V><I><T><C><D><P><L><S><Q><P><S><P><Q><P><A><D><F><T><E><T><E><T><I><L><Q><P><A><N><K><V><E><S><V><S><S><E><E><T><F><E><P><S><Q><E><L><P><A><E><A><L><R><D><P><S><L><Q><D><A><L><E><V><D><L><A><V><S><V><S><Q><I><S><I><E><E><K><V><K><E><L><S><P><E><E><E><R><R><K><W><E><E><G><R><I><D><Y><M><G><K><D><A><F><A><R><I><Q><E><K><L><D><R><F><L><Q>
Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.<BOP>
O15488
Q06546
GABPA_HUMAN
Transcription factor E4TF1-60
Homo
<M><T><K><R><E><A><E><E><L><I><E><I><E><I><D><G><T><E><K><A><E><C><T><E><E><S><I><V><E><Q><T><Y><A><P><A><E><C><V><S><Q><A><I><D><I><N><E><P><I><G><N><L><K><K><L><L><E><P><R><L><Q><C><S><L><D><A><H><E><I><C><L><Q><D><I><Q><L><D><P><E><R><S><L><F><D><Q><G><V><K><T><D><G><T><V><Q><L><S><V><Q><V><I><S><Y><Q><G><I><E><P><K><L><N><I><L><E><I><V><K><P><A><D><T><V><E><V><V><I><D><P><D><A><H><H><A><E><S><E><A><H><L><V><E><E><A><Q><V><I><T><L><D><G><T><K><H><I><T><T><I><S><D><E><T><S><E><Q><V><T><R><W><A><A><A><L><E><G><Y><R><K><E><Q><E><R><L><G><I><P><Y><D><P><I><Q><W><S><T><D><Q><V><L><H><W><V><V><W><V><M><K><E><F><S><M><T><D><I><D><L><T><T><L><N><I><S><G><R><E><L><C><S><L><N><Q><E><D><F><F><Q><R><V><P><R><G><E><I><L><W><S><H><L><E><L><L><R><K><Y><V><L><A><S><Q><E><Q><Q><M><N><E><I><V><T><I><D><Q><P><V><Q><I><I><P><A><S><V><Q><S><A><T><P><T><T><I><K><V><I><N><S><S><A><K><A><A><K><V><Q><R><A><P><R><I><S><G><E><D><R><S><S><P><G><N><R><T><G><N><N><G><Q><I><Q><L><W><Q><F><L><L><E><L><L><T><D><K><D><A><R><D><C><I><S><W><V><G><D><E><G><E><F><K><L><N><Q><P><E><L><V><A><Q><K><W><G><Q><R><K><N><K><P><T><M><N><Y><E><K><L><S><R><A><L><R><Y><Y><Y><D><G><D><M><I><C><K><V><Q><G><K><R><F><V><Y><K><F><V><C><D><L><K><T><L><I><G><Y><S><A><A><E><L><N><R><L><V><T><E><C><E><Q><K><K><L><A><K><M><Q><L><H><G><I><A><Q><P><V><T><A><V><A><L><A><T><A><S><L><Q><T><E><K><D><N>
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.<BOP>
Q06546
Q9NP91
S6A20_HUMAN
Transporter rB21A homolog
Homo
<M><E><K><A><R><P><L><W><A><N><S><L><Q><F><V><F><A><C><I><S><Y><A><V><G><L><G><N><V><W><R><F><P><Y><L><C><Q><M><Y><G><G><G><S><F><L><V><P><Y><I><I><M><L><I><V><E><G><M><P><L><L><Y><L><E><L><A><V><G><Q><R><M><R><Q><G><S><I><G><A><W><R><T><I><S><P><Y><L><S><G><V><G><V><A><S><V><V><V><S><F><F><L><S><M><Y><Y><N><V><I><N><A><W><A><F><W><Y><L><F><H><S><F><Q><D><P><L><P><W><S><V><C><P><L><N><G><N><H><T><G><Y><D><E><E><C><E><K><A><S><S><T><Q><Y><F><W><Y><R><K><T><L><N><I><S><P><S><L><Q><E><N><G><G><V><Q><W><E><P><A><L><C><L><L><L><A><W><L><V><V><Y><L><C><I><L><R><G><T><E><S><T><G><K><V><V><Y><F><T><A><S><L><P><Y><C><V><L><I><I><Y><L><I><R><G><L><T><L><H><G><A><T><N><G><L><M><Y><M><F><T><P><K><I><E><Q><L><A><N><P><K><A><W><I><N><A><A><T><Q><I><F><F><S><L><G><L><G><F><G><S><L><I><A><F><A><S><Y><N><E><P><S><N><N><C><Q><K><H><A><I><I><V><S><L><I><N><S><F><T><S><I><F><A><S><I><V><T><F><S><I><Y><G><F><K><A><T><F><N><Y><E><N><C><L><K><K><V><S><L><L><L><T><N><T><F><D><L><E><D><G><F><L><T><A><S><N><L><E><Q><V><K><G><Y><L><A><S><A><Y><P><S><K><Y><S><E><M><F><P><Q><I><K><N><C><S><L><E><S><E><L><D><T><A><V><Q><G><T><G><L><A><F><I><V><Y><T><E><A><I><K><N><M><E><V><S><Q><L><W><S><V><L><Y><F><F><M><L><L><M><L><G><I><G><S><M><L><G><N><T><A><A><I><L><T><P><L><T><D><S><K><I><I><S><S><H><L><P><K><E><A><I><S><G><L><V><C><L><V><N><C><A><I><G><M><V><F><T><M><E><A><G><N><Y><W><F><D><I><F><N><D><Y><A><A><T><L><S><L><L><L><I><V><L><V><E><T><I><A><V><C><Y><V><Y><G><L><R><R><F><E><S><D><L><K><A><M><T><G><R><A><V><S><W><Y><W><K><V><M><W><A><G><V><S><P><L><L><I><V><S><L><F><V><F><Y><L><S><D><Y><I><L><T><G><T><L><K><Y><Q><A><W><D><A><S><Q><G><Q><L><V><T><K><D><Y><P><A><Y><A><L><A><V><I><G><L><L><V><A><S><S><T><M><C><I><P><L><A><A><L><G><T><F><V><Q><R><R><L><K><R><G><D><A><D><P><V><A>
Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids . Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents .<BOP>
Q9NP91
Q14123
PDE1C_HUMAN
Hcam3
Homo
<M><E><S><P><T><K><E><I><E><E><F><E><S><N><S><L><K><Y><L><Q><P><E><Q><I><E><K><I><W><L><R><L><R><G><L><R><K><Y><K><K><T><S><Q><R><L><R><S><L><V><K><Q><L><E><R><G><E><A><S><V><V><D><L><K><K><N><L><E><Y><A><A><T><V><L><E><S><V><Y><I><D><E><T><R><R><L><L><D><T><E><D><E><L><S><D><I><Q><S><D><A><V><P><S><E><V><R><D><W><L><A><S><T><F><T><R><Q><M><G><M><M><L><R><R><S><D><E><K><P><R><F><K><S><I><V><H><A><V><Q><A><G><I><F><V><E><R><M><Y><R><R><T><S><N><M><V><G><L><S><Y><P><P><A><V><I><E><A><L><K><D><V><D><K><W><S><F><D><V><F><S><L><N><E><A><S><G><D><H><A><L><K><F><I><F><Y><E><L><L><T><R><Y><D><L><I><S><R><F><K><I><P><I><S><A><L><V><S><F><V><E><A><L><E><V><G><Y><S><K><H><K><N><P><Y><H><N><L><M><H><A><A><D><V><T><Q><T><V><H><Y><L><L><Y><K><T><G><V><A><N><W><L><T><E><L><E><I><F><A><I><I><F><S><A><A><I><H><D><Y><E><H><T><G><T><T><N><N><F><H><I><Q><T><R><S><D><P><A><I><L><Y><N><D><R><S><V><L><E><N><H><H><L><S><A><A><Y><R><L><L><Q><D><D><E><E><M><N><I><L><I><N><L><S><K><D><D><W><R><E><F><R><T><L><V><I><E><M><V><M><A><T><D><M><S><C><H><F><Q><Q><I><K><A><M><K><T><A><L><Q><Q><P><E><A><I><E><K><P><K><A><L><S><L><M><L><H><T><A><D><I><S><H><P><A><K><A><W><D><L><H><H><R><W><T><M><S><L><L><E><E><F><F><R><Q><G><D><R><E><A><E><L><G><L><P><F><S><P><L><C><D><R><K><S><T><M><V><A><Q><S><Q><V><G><F><I><D><F><I><V><E><P><T><F><T><V><L><T><D><M><T><E><K><I><V><S><P><L><I><D><E><T><S><Q><T><G><G><T><G><Q><R><R><S><S><L><N><S><I><S><S><S><D><A><K><R><S><G><V><K><T><S><G><S><E><G><S><A><P><I><N><N><S><V><I><S><V><D><Y><K><S><F><K><A><T><W><T><E><V><V><H><I><N><R><E><R><W><R><A><K><V><P><K><E><E><K><A><K><K><E><A><E><E><K><A><R><L><A><A><E><E><Q><Q><K><E><M><E><A><K><S><Q><A><E><E><G><A><S><G><K><A><E><K><K><T><S><G><E><T><K><N><Q><V><N><G><T><R><A><N><K><S><D><N><P><R><G><K><N><S><K><A><E><K><S><S><G><E><Q><Q><Q><N><G><D><F><K><D><G><K><N><K><T><D><K><K><D><H><S><N><I><G><N><D><S><K><K><T><D><G><T><K><Q><R><S><H><G><S><P><A><P><S><T><S><S><T><C><R><L><T><L><P><V><I><K><P><P><L><R><H><F><K><R><P><A><Y><A><S><S><S><Y><A><P><S><V><S><K><K><T><D><E><H><P><A><R><Y><K><M><L><D><Q><R><I><K><M><K><K><I><Q><N><I><S><H><N><W><N><R><K>
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes . Has a high affinity for both cAMP and cGMP . Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).<BOP>
Q14123
Q8N436
CPXM2_HUMAN
Inactive carboxypeptidase-like protein X2
Homo
<M><S><R><P><G><T><A><T><P><A><L><A><L><V><L><L><A><V><T><L><A><G><V><G><A><Q><G><A><A><L><E><D><P><D><Y><Y><G><Q><E><I><W><S><R><E><P><Y><Y><A><R><P><E><P><E><L><E><T><F><S><P><P><L><P><A><G><P><G><E><E><W><E><R><R><P><Q><E><P><R><P><P><K><R><A><T><K><P><K><K><A><P><K><R><E><K><S><A><P><E><P><P><P><P><G><K><H><S><N><K><K><V><M><R><T><K><S><S><E><K><A><A><N><D><D><H><S><V><R><V><A><R><E><D><V><R><E><S><C><P><P><L><G><L><E><T><L><K><I><T><D><F><Q><L><H><A><S><T><V><K><R><Y><G><L><G><A><H><R><G><R><L><N><I><Q><A><G><I><N><E><N><D><F><Y><D><G><A><W><C><A><G><R><N><D><L><Q><Q><W><I><E><V><D><A><R><R><L><T><R><F><T><G><V><I><T><Q><G><R><N><S><L><W><L><S><D><W><V><T><S><Y><K><V><M><V><S><N><D><S><H><T><W><V><T><V><K><N><G><S><G><D><M><I><F><E><G><N><S><E><K><E><I><P><V><L><N><E><L><P><V><P><M><V><A><R><Y><I><R><I><N><P><Q><S><W><F><D><N><G><S><I><C><M><R><M><E><I><L><G><C><P><L><P><D><P><N><N><Y><Y><H><R><R><N><E><M><T><T><T><D><D><L><D><F><K><H><H><N><Y><K><E><M><R><Q><L><M><K><V><V><N><E><M><C><P><N><I><T><R><I><Y><N><I><G><K><S><H><Q><G><L><K><L><Y><A><V><E><I><S><D><H><P><G><E><H><E><V><G><E><P><E><F><H><Y><I><A><G><A><H><G><N><E><V><L><G><R><E><L><L><L><L><L><V><Q><F><V><C><Q><E><Y><L><A><R><N><A><R><I><V><H><L><V><E><E><T><R><I><H><V><L><P><S><L><N><P><D><G><Y><E><K><A><Y><E><G><G><S><E><L><G><G><W><S><L><G><R><W><T><H><D><G><I><D><I><N><N><N><F><P><D><L><N><T><L><L><W><E><A><E><D><R><Q><N><V><P><R><K><V><P><N><H><Y><I><A><I><P><E><W><F><L><S><E><N><A><T><V><A><A><E><T><R><A><V><I><A><W><M><E><K><I><P><F><V><L><G><G><N><L><Q><G><G><E><L><V><V><A><Y><P><Y><D><L><V><R><S><P><W><K><T><Q><E><H><T><P><T><P><D><D><H><V><F><R><W><L><A><Y><S><Y><A><S><T><H><R><L><M><T><D><A><R><R><R><V><C><H><T><E><D><F><Q><K><E><E><G><T><V><N><G><A><S><W><H><T><V><A><G><S><L><N><D><F><S><Y><L><H><T><N><C><F><E><L><S><I><Y><V><G><C><D><K><Y><P><H><E><S><Q><L><P><E><E><W><E><N><N><R><E><S><L><I><V><F><M><E><Q><V><H><R><G><I><K><G><L><V><R><D><S><H><G><K><G><I><P><N><A><I><I><S><V><E><G><I><N><H><D><I><R><T><A><N><D><G><D><Y><W><R><L><L><N><P><G><E><Y><V><V><T><A><K><A><E><G><F><T><A><S><T><K><N><C><M><V><G><Y><D><M><G><A><T><R><C><D><F><T><L><S><K><T><N><M><A><R><I><R><E><I><M><E><K><F><G><K><Q><P><V><S><L><P><A><R><R><L><K><L><R><G><Q><K><R><R><Q><R><G>
May be involved in cell-cell interactions.<BOP>
Q8N436
Q96EY1
DNJA3_HUMAN
Tumorous imaginal discs protein Tid56 homolog
Homo
<M><A><A><R><C><S><T><R><W><L><L><V><V><V><G><T><P><R><L><P><A><I><S><G><R><G><A><R><P><P><R><E><G><V><V><G><A><W><L><S><R><K><L><S><V><P><A><F><A><S><S><L><T><S><C><G><P><R><A><L><L><T><L><R><P><G><V><S><L><T><G><T><K><H><N><P><F><I><C><T><A><S><F><H><T><S><A><P><L><A><K><E><D><Y><Y><Q><I><L><G><V><P><R><N><A><S><Q><K><E><I><K><K><A><Y><Y><Q><L><A><K><K><Y><H><P><D><T><N><K><D><D><P><K><A><K><E><K><F><S><Q><L><A><E><A><Y><E><V><L><S><D><E><V><K><R><K><Q><Y><D><A><Y><G><S><A><G><F><D><P><G><A><S><G><S><Q><H><S><Y><W><K><G><G><P><T><V><D><P><E><E><L><F><R><K><I><F><G><E><F><S><S><S><S><F><G><D><F><Q><T><V><F><D><Q><P><Q><E><Y><F><M><E><L><T><F><N><Q><A><A><K><G><V><N><K><E><F><T><V><N><I><M><D><T><C><E><R><C><N><G><K><G><N><E><P><G><T><K><V><Q><H><C><H><Y><C><G><G><S><G><M><E><T><I><N><T><G><P><F><V><M><R><S><T><C><R><R><C><G><G><R><G><S><I><I><I><S><P><C><V><V><C><R><G><A><G><Q><A><K><Q><K><K><R><V><M><I><P><V><P><A><G><V><E><D><G><Q><T><V><R><M><P><V><G><K><R><E><I><F><I><T><F><R><V><Q><K><S><P><V><F><R><R><D><G><A><D><I><H><S><D><L><F><I><S><I><A><Q><A><L><L><G><G><T><A><R><A><Q><G><L><Y><E><T><I><N><V><T><I><P><P><G><T><Q><T><D><Q><K><I><R><M><G><G><K><G><I><P><R><I><N><S><Y><G><Y><G><D><H><Y><I><H><I><K><I><R><V><P><K><R><L><T><S><R><Q><Q><S><L><I><L><S><Y><A><E><D><E><T><D><V><E><G><T><V><N><G><V><T><L><T><S><S><G><G><S><T><M><D><S><S><A><G><S><K><A><R><R><E><A><G><E><D><E><E><G><F><L><S><K><L><K><K><M><F><T><S>
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.<BOP>
Q96EY1
Q96MH2
HEXI2_HUMAN
Hexamethylene bis-acetamide-inducible protein 2
Homo
<M><M><A><T><P><N><Q><T><A><C><N><A><E><S><P><V><A><L><E><E><A><K><T><S><G><A><P><G><S><P><Q><T><P><P><E><R><H><D><S><G><G><S><L><P><L><T><P><R><M><E><S><H><S><E><D><E><D><L><A><G><A><V><G><G><L><G><W><N><S><R><S><P><R><T><Q><S><P><G><G><C><S><A><E><A><V><L><A><R><K><K><H><R><R><R><P><S><K><R><K><R><H><W><R><P><Y><L><E><L><S><W><A><E><K><Q><Q><R><D><E><R><Q><S><Q><R><A><S><R><V><R><E><E><M><F><A><K><G><Q><P><V><A><P><Y><N><T><T><Q><F><L><M><N><D><R><D><P><E><E><P><N><L><D><V><P><H><G><I><S><H><P><G><S><S><G><E><S><E><A><G><D><S><D><G><R><G><R><A><H><G><E><F><Q><R><K><D><F><S><E><T><Y><E><R><F><H><T><E><S><L><Q><G><R><S><K><Q><E><L><V><R><D><Y><L><E><L><E><K><R><L><S><Q><A><E><E><E><T><R><R><L><Q><Q><L><Q><A><C><T><G><Q><Q><S><C><R><Q><V><E><E><L><A><A><E><V><Q><R><L><R><T><E><N><Q><R><L><R><Q><E><N><Q><M><W><N><R><E><G><C><R><C><D><E><E><P><G><T>
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor . Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation .<BOP>
Q96MH2
P29083
T2EA_HUMAN
Transcription initiation factor IIE subunit alpha
Homo
<M><A><D><P><D><V><L><T><E><V><P><A><A><L><K><R><L><A><K><Y><V><I><R><G><F><Y><G><I><E><H><A><L><A><L><D><I><L><I><R><N><S><C><V><K><E><E><D><M><L><E><L><L><K><F><D><R><K><Q><L><R><S><V><L><N><N><L><K><G><D><K><F><I><K><C><R><M><R><V><E><T><A><A><D><G><K><T><T><R><H><N><Y><Y><F><I><N><Y><R><T><L><V><N><V><V><K><Y><K><L><D><H><M><R><R><R><I><E><T><D><E><R><D><S><T><N><R><A><S><F><K><C><P><V><C><S><S><T><F><T><D><L><E><A><N><Q><L><F><D><P><M><T><G><T><F><R><C><T><F><C><H><T><E><V><E><E><D><E><S><A><M><P><K><K><D><A><R><T><L><L><A><R><F><N><E><Q><I><E><P><I><Y><A><L><L><R><E><T><E><D><V><N><L><A><Y><E><I><L><E><P><E><P><T><E><I><P><A><L><K><Q><S><K><D><H><A><A><T><T><A><G><A><A><S><L><A><G><G><H><H><R><E><A><W><A><T><K><G><P><S><Y><E><D><L><Y><T><Q><N><V><V><I><N><M><D><D><Q><E><D><L><H><R><A><S><L><E><G><K><S><A><K><E><R><P><I><W><L><R><E><S><T><V><Q><G><A><Y><G><S><E><D><M><K><E><G><G><I><D><M><D><A><F><Q><E><R><E><E><G><H><A><G><P><D><D><N><E><E><V><M><R><A><L><L><I><H><E><K><K><T><S><S><A><M><A><G><S><V><G><A><A><A><P><V><T><A><A><N><G><S><D><S><E><S><E><T><S><E><S><D><D><D><S><P><P><R><P><A><A><V><A><V><H><K><R><E><E><D><E><E><E><D><D><E><F><E><E><V><A><D><D><P><I><V><M><V><A><G><R><P><F><S><Y><S><E><V><S><Q><R><P><E><L><V><A><Q><M><T><P><E><E><K><E><A><Y><I><A><M><G><Q><R><M><F><E><D><L><F><E>
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.<BOP>
P29083
Q8IYF1
ELOA2_HUMAN
Transcription elongation factor B polypeptide 3B
Homo
<M><A><A><G><S><T><T><L><H><A><V><E><K><L><Q><V><R><L><A><T><K><T><E><P><K><K><L><E><K><Y><L><Q><K><L><S><A><L><P><M><T><A><D><I><L><A><E><T><G><I><R><K><T><V><K><R><L><R><K><H><Q><H><V><G><D><F><A><R><D><L><A><A><R><W><K><K><L><V><L><V><D><R><N><T><R><P><G><P><Q><D><P><E><E><S><A><S><R><Q><R><F><G><E><A><L><Q><D><Q><E><K><A><W><G><F><P><E><N><A><T><A><P><R><S><P><S><H><S><P><E><H><R><R><T><A><R><R><T><P><P><G><Q><Q><R><P><H><P><R><S><H><S><R><E><P><R><A><E><R><K><C><P><R><I><A><P><A><D><S><G><R><Y><R><A><S><P><T><R><T><A><P><L><R><M><P><E><G><P><E><P><A><A><P><G><K><Q><P><G><R><G><H><T><H><A><A><Q><G><G><P><L><L><C><P><G><C><Q><G><Q><P><Q><G><K><A><V><V><S><H><S><K><G><H><K><S><S><R><Q><E><K><R><P><L><C><A><Q><G><D><W><H><S><P><T><L><I><R><E><K><S><C><G><A><C><L><R><E><E><T><P><R><M><P><S><W><A><S><A><R><D><R><Q><P><S><D><F><K><T><D><K><E><G><G><Q><A><G><S><G><Q><R><V><P><A><L><E><E><A><P><D><S><H><Q><K><R><P><Q><H><S><H><S><N><K><K><R><P><S><L><D><G><R><D><P><G><N><G><T><H><G><L><S><P><E><E><K><E><Q><L><S><N><D><R><E><T><Q><E><G><K><P><P><T><A><H><L><D><R><T><S><V><S><S><L><S><E><V><E><E><V><D><M><A><E><E><F><E><Q><P><T><L><S><C><E><K><Y><L><T><Y><D><Q><L><R><K><Q><K><K><K><T><G><K><S><A><T><T><A><L><G><D><K><Q><R><K><A><N><E><S><K><G><T><R><E><S><W><D><S><A><K><K><L><P><P><V><Q><E><S><Q><S><E><R><L><Q><A><A><G><A><D><S><A><G><P><K><T><V><P><S><H><V><F><S><E><L><W><D><L><S><E><A><W><M><Q><A><N><Y><D><P><L><S><D><S><D><S><M><T><S><Q><A><K><P><E><A><L><S><S><P><K><F><R><E><E><A><A><F><P><G><R><R><V><N><A><K><M><P><V><Y><S><G><S><R><P><A><C><Q><L><Q><V><P><T><L><R><Q><Q><C><A><Q><V><L><R><N><N><P><D><A><L><S><D><V><G><E><V><P><Y><W><V><L><E><P><V><L><E><G><W><R><P><D><Q><L><Y><R><R><K><K><D><N><H><A><L><V><R><E><T><D><E><L><R><R><N><H><C><F><Q><D><F><K><E><E><K><P><Q><E><N><K><T><W><R><E><Q><Y><L><R><L><P><D><A><P><E><Q><R><L><R><V><M><T><T><N><I><R><S><A><R><G><N><N><P><N><G><R><E><A><K><M><I><C><F><K><S><V><A><K><T><P><Y><D><T><S><R><R><Q><E><K><S><A><G><D><A><D><P><E><N><G><E><I><K><P><A><S><K><P><A><G><S><S><H><T><P><S><S><Q><S><S><S><G><G><G><R><D><S><S><S><S><I><L><R><W><L><P><E><K><R><A><N><P><C><L><S><S><S><N><E><H><A><A><P><A><A><K><T><R><K><Q><A><A><K><K><V><A><P><L><M><A><K><A><I><R><D><Y><K><R><R><F><S><R><R>
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<BOP>
Q8IYF1
Q8IYX7
SAXO1_HUMAN
Stabilizer of axonemal microtubules 1
Homo
<M><K><T><K><C><I><C><E><L><C><S><C><G><R><H><H><C><P><H><L><P><T><K><I><Y><D><K><T><E><K><P><C><L><L><S><E><Y><T><E><N><Y><P><F><Y><H><S><Y><L><P><R><E><S><F><K><P><R><R><E><Y><Q><K><G><P><I><P><M><E><G><L><T><T><S><R><R><D><F><G><P><H><K><V><A><P><V><K><V><H><Q><Y><D><Q><F><V><P><S><E><E><N><M><D><L><L><T><T><Y><K><K><D><Y><N><P><Y><P><V><C><R><V><D><P><I><K><P><R><D><S><K><Y><P><C><S><D><K><M><E><C><L><P><T><Y><K><A><D><Y><L><P><W><N><Q><P><R><R><E><P><L><R><L><E><H><K><Y><Q><P><A><S><V><R><F><D><N><R><T><T><H><Q><D><D><Y><P><I><K><G><L><V><K><T><I><S><C><K><P><L><A><M><P><K><L><C><N><I><P><L><E><D><V><T><N><Y><K><M><S><Y><V><A><H><P><V><E><K><R><F><V><H><E><A><E><K><F><R><P><C><E><I><P><F><E><S><L><T><T><Q><K><Q><S><Y><R><G><L><M><G><E><P><A><K><S><L><K><P><L><A><R><P><P><G><L><D><M><P><F><C><N><T><T><E><F><R><D><K><Y><Q><A><W><P><M><P><R><M><F><S><K><A><P><I><T><Y><V><P><P><E><D><R><M><D><L><L><T><T><V><Q><A><H><Y><T><C><P><K><G><A><P><A><Q><S><C><R><P><A><L><Q><I><K><K><C><G><R><F><E><G><S><S><T><T><K><D><D><Y><K><Q><W><S><S><M><R><T><E><P><V><K><P><V><P><Q><L><D><L><P><T><E><P><L><D><C><L><T><T><T><R><A><H><Y><V><P><H><L><P><I><N><T><K><S><C><K><P><H><W><S><G><P><R><G><N><V><P><V><E><S><Q><T><T><Y><T><I><S><F><T><P><K><E><M><G><R><C><L><A><S><Y><P><E><P><P><G><Y><T><F><E><E><V><D><A><L><G><H><R><I><Y><K><P><V><S><Q><A><G><S><Q><Q><S><S><H><L><S><V><D><D><S><E><N><P><N><Q><R><E><L><E><V><L><A>
May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature.<BOP>
Q8IYX7
Q6UXB4
CLC4G_HUMAN
Liver and lymph node sinusoidal endothelial cell C-type lectin
Homo
<M><D><T><T><R><Y><S><K><W><G><G><S><S><E><E><V><P><G><G><P><W><G><R><W><V><H><W><S><R><R><P><L><F><L><A><L><A><V><L><V><T><T><V><L><W><A><V><I><L><S><I><L><L><S><K><A><S><T><E><R><A><A><L><L><D><G><H><D><L><L><R><T><N><A><S><K><Q><T><A><A><L><G><A><L><K><E><E><V><G><D><C><H><S><C><C><S><G><T><Q><A><Q><L><Q><T><T><R><A><E><L><G><E><A><Q><A><K><L><M><E><Q><E><S><A><L><R><E><L><R><E><R><V><T><Q><G><L><A><E><A><G><R><G><R><E><D><V><R><T><E><L><F><R><A><L><E><A><V><R><L><Q><N><N><S><C><E><P><C><P><T><S><W><L><S><F><E><G><S><C><Y><F><F><S><V><P><K><T><T><W><A><A><A><Q><D><H><C><A><D><A><S><A><H><L><V><I><V><G><G><L><D><E><Q><G><F><L><T><R><N><T><R><G><R><G><Y><W><L><G><L><R><A><V><R><H><L><G><K><V><Q><G><Y><Q><W><V><D><G><V><S><L><S><F><S><H><W><N><Q><G><E><P><N><D><A><W><G><R><E><N><C><V><M><M><L><H><T><G><L><W><N><D><A><P><C><D><S><E><K><D><G><W><I><C><E><K><R><H><N><C>
(Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein .<BOP>
Q6UXB4
O95968
SG1D1_HUMAN
Lipophilin-A
Homo
<M><R><L><S><V><C><L><L><L><L><T><L><A><L><C><C><Y><R><A><N><A><V><V><C><Q><A><L><G><S><E><I><T><G><F><L><L><A><G><K><P><V><F><K><F><Q><L><A><K><F><K><A><P><L><E><A><V><A><A><K><M><E><V><K><K><C><V><D><T><M><A><Y><E><K><R><V><L><I><T><K><T><L><G><K><I><A><E><K><C><D><R>
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.<BOP>
O95968
P17014
ZNF12_HUMAN
Zinc finger protein KOX3
Homo
<M><N><K><S><L><G><P><V><S><F><K><D><V><A><V><D><F><T><Q><E><E><W><Q><Q><L><D><P><E><Q><K><I><T><Y><R><D><V><M><L><E><N><Y><S><N><L><V><S><V><G><Y><H><I><I><K><P><D><V><I><S><K><L><E><Q><G><E><E><P><W><I><V><E><G><E><F><L><L><Q><S><Y><P><D><E><V><W><Q><T><D><D><L><I><E><R><I><Q><E><E><E><N><K><P><S><R><Q><T><V><F><I><E><T><L><I><E><E><R><G><N><V><P><G><K><T><F><D><V><E><T><N><P><V><P><S><R><K><I><A><Y><K><N><S><L><C><D><S><C><E><K><C><L><T><S><V><S><E><Y><I><S><S><D><G><S><Y><A><R><M><K><A><D><E><C><S><G><C><G><K><S><L><L><H><I><K><L><E><K><T><H><P><G><D><Q><A><Y><E><F><N><Q><N><G><E><P><Y><T><L><N><E><E><S><L><Y><Q><K><I><R><I><L><E><K><P><F><E><Y><I><E><C><Q><K><A><F><Q><K><D><T><V><F><V><N><H><M><E><E><K><P><Y><K><W><N><G><S><E><I><A><F><L><Q><M><S><D><L><T><V><H><Q><T><S><H><M><E><M><K><P><Y><E><C><S><E><C><G><K><S><F><C><K><K><S><K><F><I><I><H><Q><R><T><H><T><G><E><K><P><Y><E><C><N><Q><C><G><K><S><F><C><Q><K><G><T><L><T><V><H><Q><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><N><F><Y><Q><K><L><H><L><I><Q><H><Q><R><T><H><S><G><E><K><P><Y><E><C><S><Y><C><G><K><S><F><C><Q><K><T><H><L><T><Q><H><Q><R><T><H><S><G><E><R><P><Y><V><C><H><D><C><G><K><T><F><S><Q><K><S><A><L><N><D><H><Q><K><I><H><T><G><V><K><L><Y><K><C><S><E><C><G><K><C><F><C><R><K><S><T><L><T><T><H><L><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><F><F><S><R><L><S><Y><L><T><V><H><Y><R><T><H><S><G><E><K><P><Y><E><C><N><E><C><G><K><T><F><Y><L><N><S><A><L><M><R><H><Q><R><V><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><L><F><S><Q><L><S><Y><L><T><I><H><H><R><T><H><S><G><V><K><P><Y><E><C><S><E><C><G><K><T><F><Y><Q><N><S><A><L><C><R><H><R><R><I><H><K><G><E><K><P><Y><E><C><Y><I><C><G><K><F><F><S><Q><M><S><Y><L><T><I><H><H><R><I><H><S><G><E><K><P><Y><E><C><S><E><C><G><K><T><F><C><Q><N><S><A><L><N><R><H><Q><R><T><H><T><G><E><K><A><Y><E><C><Y><E><C><G><K><C><F><S><Q><M><S><Y><L><T><I><H><H><R><I><H><S><G><E><K><P><F><E><C><N><E><C><G><K><A><F><S><R><M><S><Y><L><T><V><H><Y><R><T><H><S><G><E><K><P><Y><E><C><T><E><C><G><K><K><F><Y><H><K><S><A><F><N><S><H><Q><R><I><H><R><R><G><N><M><N><V><I><D><V><G><R><L><L>
Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.<BOP>
P17014
Q6JEL2
KLH10_HUMAN
Kelch-like protein 10
Homo
<M><E><M><E><S><A><A><A><S><T><R><F><H><Q><P><H><M><E><R><K><M><S><A><M><A><C><E><I><F><N><E><L><R><L><E><G><K><L><C><D><V><V><I><K><V><N><G><F><E><F><S><A><H><K><N><I><L><C><S><C><S><S><Y><F><R><A><L><F><T><S><G><W><N><N><T><E><K><K><V><Y><N><I><P><G><I><S><P><D><M><M><K><L><I><I><E><Y><A><Y><T><R><T><V><P><I><T><P><D><N><V><E><K><L><L><A><A><A><D><Q><F><N><I><M><G><I><V><R><G><C><C><E><F><L><K><S><E><L><C><L><D><N><C><I><G><I><C><K><F><T><D><Y><Y><Y><C><P><E><L><R><Q><K><A><Y><M><F><I><L><H><N><F><E><E><M><V><K><V><S><A><E><F><L><E><L><S><V><T><E><L><K><D><I><I><E><K><D><E><L><N><V><K><Q><E><D><A><V><F><E><A><I><L><K><W><I><S><H><D><P><Q><N><R><K><Q><H><I><S><I><L><L><P><K><V><R><L><A><L><M><H><A><E><Y><F><M><N><N><V><K><M><N><D><Y><V><K><D><S><E><E><C><K><P><V><I><I><N><A><L><K><A><M><Y><D><L><N><M><N><G><P><S><N><S><D><F><T><N><P><L><T><R><P><R><L><P><Y><A><I><L><F><A><I><G><G><W><S><G><G><S><P><T><N><A><I><E><A><Y><D><A><R><A><D><R><W><V><N><V><T><C><E><E><E><S><P><R><A><Y><H><G><A><A><Y><L><K><G><Y><V><Y><I><I><G><G><F><D><S><V><D><Y><F><N><S><V><K><R><F><D><P><V><K><K><T><W><H><Q><V><A><P><M><H><S><R><R><C><Y><V><S><V><T><V><L><G><N><F><I><Y><A><M><G><G><F><D><G><Y><V><R><L><N><T><A><E><R><Y><E><P><E><T><N><Q><W><T><L><I><A><P><M><H><E><Q><R><S><D><A><S><A><T><T><L><Y><G><K><V><Y><I><C><G><G><F><N><G><N><E><C><L><F><T><A><E><V><Y><N><T><E><S><N><Q><W><T><V><I><A><P><M><R><S><R><R><S><G><I><G><V><I><A><Y><G><E><H><V><Y><A><V><G><G><F><D><G><A><N><R><L><R><S><A><E><A><Y><S><P><V><A><N><T><W><R><T><I><P><T><M><F><N><P><R><S><N><F><G><I><E><V><V><D><D><L><L><F><V><V><G><G><F><N><G><F><T><T><T><F><N><V><E><C><Y><D><E><K><T><D><E><W><Y><D><A><H><D><M><S><I><Y><R><S><A><L><S><C><C><V><V><P><G><L><A><N><V><E><E><Y><A><A><R><R><D><N><F><P><G><L><A><L><R><D><E><V><K><Y><S><A><S><T><S><T><L><P><V>
May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.<BOP>
Q6JEL2
Q96KC2
ARL5B_HUMAN
ADP-ribosylation factor-like protein 8
Homo
<M><G><L><I><F><A><K><L><W><S><L><F><C><N><Q><E><H><K><V><I><I><V><G><L><D><N><A><G><K><T><T><I><L><Y><Q><F><L><M><N><E><V><V><H><T><S><P><T><I><G><S><N><V><E><E><I><V><V><K><N><T><H><F><L><M><W><D><I><G><G><Q><E><S><L><R><S><S><W><N><T><Y><Y><S><N><T><E><F><I><I><L><V><V><D><S><I><D><R><E><R><L><A><I><T><K><E><E><L><Y><R><M><L><A><H><E><D><L><R><K><A><A><V><L><I><F><A><N><K><Q><D><M><K><G><C><M><T><A><A><E><I><S><K><Y><L><T><L><S><S><I><K><D><H><P><W><H><I><Q><S><C><C><A><L><T><G><E><G><L><C><Q><G><L><E><W><M><T><S><R><I><G><V><R>
Binds and exchanges GTP and GDP.<BOP>
Q96KC2
Q8NGJ4
O52E2_HUMAN
Olfactory receptor 52E2
Homo
<M><F><L><P><N><D><T><Q><F><H><P><S><S><F><L><L><L><G><I><P><G><L><E><T><L><H><I><W><I><G><F><P><F><C><A><V><Y><M><I><A><L><I><G><N><F><T><I><L><L><V><I><K><T><D><S><S><L><H><Q><P><M><F><Y><F><L><A><M><L><A><T><T><D><V><G><L><S><T><A><T><I><P><K><M><L><G><I><F><W><I><N><L><R><G><I><I><F><E><A><C><L><T><Q><M><F><F><I><H><N><F><T><L><M><E><S><A><V><L><V><A><M><A><Y><D><S><Y><V><A><I><C><N><P><L><Q><Y><S><A><I><L><T><N><K><V><V><S><V><I><G><L><G><V><F><V><R><A><L><I><F><V><I><P><S><I><L><L><I><L><R><L><P><F><C><G><N><H><V><I><P><H><T><Y><C><E><H><M><G><L><A><H><L><S><C><A><S><I><K><I><N><I><I><Y><G><L><C><A><I><C><N><L><V><F><D><I><T><V><I><A><L><S><Y><V><H><I><L><C><A><V><F><R><L><P><T><H><E><A><R><L><K><S><L><S><T><C><G><S><H><V><C><V><I><L><A><F><Y><T><P><A><L><F><S><F><M><T><H><R><F><G><R><N><V><P><R><Y><I><H><I><L><L><A><N><L><Y><V><V><V><P><P><M><L><N><P><V><I><Y><G><V><R><T><K><Q><I><Y><K><C><V><K><K><I><L><L><Q><E><Q><G><M><E><K><E><E><Y><L><I><H><T><R><F>
Odorant receptor.<BOP>
Q8NGJ4
O94760
DDAH1_HUMAN
Dimethylargininase-1
Homo
<M><A><G><L><G><H><P><A><A><F><G><R><A><T><H><A><V><V><R><A><L><P><E><S><L><G><Q><H><A><L><R><S><A><K><G><E><E><V><D><V><A><R><A><E><R><Q><H><Q><L><Y><V><G><V><L><G><S><K><L><G><L><Q><V><V><E><L><P><A><D><E><S><L><P><D><C><V><F><V><E><D><V><A><V><V><C><E><E><T><A><L><I><T><R><P><G><A><P><S><R><R><K><E><V><D><M><M><K><E><A><L><E><K><L><Q><L><N><I><V><E><M><K><D><E><N><A><T><L><D><G><G><D><V><L><F><T><G><R><E><F><F><V><G><L><S><K><R><T><N><Q><R><G><A><E><I><L><A><D><T><F><K><D><Y><A><V><S><T><V><P><V><A><D><G><L><H><L><K><S><F><C><S><M><A><G><P><N><L><I><A><I><G><S><S><E><S><A><Q><K><A><L><K><I><M><Q><Q><M><S><D><H><R><Y><D><K><L><T><V><P><D><D><I><A><A><N><C><I><Y><L><N><I><P><N><K><G><H><V><L><L><H><R><T><P><E><E><Y><P><E><S><A><K><V><Y><E><K><L><K><D><H><M><L><I><P><V><S><M><S><E><L><E><K><V><D><G><L><L><T><C><C><S><V><L><I><N><K><K><V><D><S>
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.<BOP>
O94760
Q8N5C1
CAHM5_HUMAN
Protein FAM26E
Homo
<M><D><A><F><Q><G><I><L><K><F><F><L><N><Q><K><T><V><I><G><Y><S><F><M><A><L><L><T><V><G><S><E><R><L><F><S><V><V><A><F><K><C><P><C><S><T><E><N><M><T><Y><G><L><V><F><L><F><A><P><A><W><V><L><L><I><L><G><F><F><L><N><N><R><S><W><R><L><F><T><G><C><C><V><N><P><R><K><I><F><P><R><G><H><S><C><R><F><F><Y><V><L><G><Q><I><T><L><S><S><L><V><A><P><V><M><W><L><S><V><A><L><L><N><G><T><F><Y><E><C><A><M><S><G><T><R><S><S><G><L><L><E><L><I><C><K><G><K><P><K><E><C><W><E><E><L><H><K><V><S><C><G><K><T><S><M><L><P><T><V><N><E><E><L><K><L><S><L><Q><A><Q><S><Q><I><L><G><W><C><L><I><C><S><A><S><F><F><S><L><L><T><T><C><Y><A><R><C><R><S><K><V><S><Y><L><Q><L><S><F><W><K><T><Y><A><Q><K><E><K><E><Q><L><E><N><T><F><L><D><Y><A><N><K><L><S><E><R><N><L><K><C><F><F><E><N><K><R><P><D><P><F><P><M><P><T><F><A><A><W><E><A><A><S><E><L><H><S><F><H><Q><S><Q><Q><H><Y><S><T><L><H><R><V><V><D><N><G><L><Q><L><S><P><E><D><D><E><T><T><M><V><L><V><G><T><A><H><N><M>
Pore-forming subunit of a voltage-gated ion channel.<BOP>
Q8N5C1
Q8N0V4
LGI2_HUMAN
Leucine-rich glioma-inactivated protein 2
Homo
<M><A><L><R><R><G><G><C><G><A><L><G><L><L><L><L><L><L><G><A><A><C><L><I><P><R><S><A><Q><V><R><R><L><A><R><C><P><A><T><C><S><C><T><K><E><S><I><I><C><V><G><S><S><W><V><P><R><I><V><P><G><D><I><S><S><L><S><L><V><N><G><T><F><S><E><I><K><D><R><M><F><S><H><L><P><S><L><Q><L><L><L><L><N><S><N><S><F><T><I><I><R><D><D><A><F><A><G><L><F><H><L><E><Y><L><F><I><E><G><N><K><I><E><T><I><S><R><N><A><F><R><G><L><R><D><L><T><H><L><S><L><A><N><N><H><I><K><A><L><P><R><D><V><F><S><D><L><D><S><L><I><E><L><D><L><R><G><N><K><F><E><C><D><C><K><A><K><W><L><Y><L><W><L><K><M><T><N><S><T><V><S><D><V><L><C><I><G><P><P><E><Y><Q><E><K><K><L><N><D><V><T><S><F><D><Y><E><C><T><T><T><D><F><V><V><H><Q><T><L><P><Y><Q><S><V><S><V><D><T><F><N><S><K><N><D><V><Y><V><A><I><A><Q><P><S><M><E><N><C><M><V><L><E><W><D><H><I><E><M><N><F><R><S><Y><D><N><I><T><G><Q><S><I><V><G><C><K><A><I><L><I><D><D><Q><V><F><V><V><V><A><Q><L><F><G><G><S><H><I><Y><K><Y><D><E><S><W><T><K><F><V><K><F><Q><D><I><E><V><S><R><I><S><K><P><N><D><I><E><L><F><Q><I><D><D><E><T><F><F><V><I><A><D><S><S><K><A><G><L><S><T><V><Y><K><W><N><S><K><G><F><Y><S><Y><Q><S><L><H><E><W><F><R><D><T><D><A><E><F><V><D><I><D><G><K><S><H><L><I><L><S><S><R><S><Q><V><P><I><I><L><Q><W><N><K><S><S><K><K><F><V><P><H><G><D><I><P><N><M><E><D><V><L><A><V><K><S><F><R><M><Q><N><T><L><Y><L><S><L><T><R><F><I><G><D><S><R><V><M><R><W><N><S><K><Q><F><V><E><I><Q><A><L><P><S><R><G><A><M><T><L><Q><P><F><S><F><K><D><N><H><Y><L><A><L><G><S><D><Y><T><F><S><Q><I><Y><Q><W><D><K><E><K><Q><L><F><K><K><F><K><E><I><Y><V><Q><A><P><R><S><F><T><A><V><S><T><D><R><R><D><F><F><F><A><S><S><F><K><G><K><T><K><I><F><E><H><I><I><V><D><L><S><L>
Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells.<BOP>
Q8N0V4
Q9UC06
ZNF70_HUMAN
Zinc finger protein N27C7-1
Homo
<M><E><V><P><P><A><T><K><F><G><E><T><F><A><F><E><N><R><L><E><S><Q><Q><G><L><F><P><G><E><D><L><G><D><P><F><L><Q><E><R><G><L><E><Q><M><A><V><I><Y><K><E><I><P><L><G><E><Q><D><E><E><N><D><D><Y><E><G><N><F><S><L><C><S><S><P><V><Q><H><Q><S><I><P><P><G><T><R><P><Q><D><D><E><L><F><G><Q><T><F><L><Q><K><S><D><L><S><M><C><Q><I><I><H><S><E><E><P><S><P><C><D><C><A><E><T><D><R><G><D><S><G><P><N><A><P><H><R><T><P><Q><P><A><K><P><Y><A><C><R><E><C><G><K><A><F><S><Q><S><S><H><L><L><R><H><L><V><I><H><T><G><E><K><P><Y><E><C><C><E><C><G><K><A><F><S><Q><S><S><H><L><L><R><H><Q><I><I><H><T><G><E><K><P><Y><E><C><R><E><C><G><K><A><F><R><Q><S><S><A><L><T><Q><H><Q><K><I><H><T><G><K><R><P><Y><E><C><R><E><C><G><K><D><F><S><R><S><S><S><L><R><K><H><E><R><I><H><T><G><E><R><P><Y><Q><C><K><E><C><G><K><S><F><N><Q><S><S><G><L><S><Q><H><R><K><I><H><T><L><K><K><P><H><E><C><D><L><C><G><K><A><F><C><H><R><S><H><L><I><R><H><Q><R><I><H><T><G><K><K><P><Y><K><C><D><E><C><G><K><A><F><S><Q><S><S><N><L><I><E><H><R><K><T><H><T><G><E><K><P><Y><K><C><Q><K><C><G><K><A><F><S><Q><S><S><S><L><I><E><H><Q><R><I><H><T><G><E><K><P><Y><E><C><C><Q><C><G><K><A><F><C><H><S><S><A><L><I><Q><H><Q><R><I><H><T><G><K><K><P><Y><T><C><E><C><G><K><A><F><R><H><R><S><A><L><I><E><H><Y><K><T><H><T><R><E><K><P><Y><V><C><N><L><C><G><K><S><F><R><G><S><S><H><L><I><R><H><Q><K><I><H><S><G><E><K><L>
May be involved in transcriptional regulation.<BOP>
Q9UC06
Q15797
SMAD1_HUMAN
Transforming growth factor-beta-signaling protein 1
Homo
<M><N><V><T><S><L><F><S><F><T><S><P><A><V><K><R><L><L><G><W><K><Q><G><D><E><E><E><K><W><A><E><K><A><V><D><A><L><V><K><K><L><K><K><K><K><G><A><M><E><E><L><E><K><A><L><S><C><P><G><Q><P><S><N><C><V><T><I><P><R><S><L><D><G><R><L><Q><V><S><H><R><K><G><L><P><H><V><I><Y><C><R><V><W><R><W><P><D><L><Q><S><H><H><E><L><K><P><L><E><C><C><E><F><P><F><G><S><K><Q><K><E><V><C><I><N><P><Y><H><Y><K><R><V><E><S><P><V><L><P><P><V><L><V><P><R><H><S><E><Y><N><P><Q><H><S><L><L><A><Q><F><R><N><L><G><Q><N><E><P><H><M><P><L><N><A><T><F><P><D><S><F><Q><Q><P><N><S><H><P><F><P><H><S><P><N><S><S><Y><P><N><S><P><G><S><S><S><S><T><Y><P><H><S><P><T><S><S><D><P><G><S><P><F><Q><M><P><A><D><T><P><P><P><A><Y><L><P><P><E><D><P><M><T><Q><D><G><S><Q><P><M><D><T><N><M><M><A><P><P><L><P><S><E><I><N><R><G><D><V><Q><A><V><A><Y><E><E><P><K><H><W><C><S><I><V><Y><Y><E><L><N><N><R><V><G><E><A><F><H><A><S><S><T><S><V><L><V><D><G><F><T><D><P><S><N><N><K><N><R><F><C><L><G><L><L><S><N><V><N><R><N><S><T><I><E><N><T><R><R><H><I><G><K><G><V><H><L><Y><Y><V><G><G><E><V><Y><A><E><C><L><S><D><S><S><I><F><V><Q><S><R><N><C><N><Y><H><H><G><F><H><P><T><T><V><C><K><I><P><S><G><C><S><L><K><I><F><N><N><Q><E><F><A><Q><L><L><A><Q><S><V><N><H><G><F><E><T><V><Y><E><L><T><K><M><C><T><I><R><M><S><F><V><K><G><W><G><A><E><Y><H><R><Q><D><V><T><S><T><P><C><W><I><E><I><H><L><H><G><P><L><Q><W><L><D><K><V><L><T><Q><M><G><S><P><H><N><P><I><S><S><V><S>
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.<BOP>
Q15797
Q9UGH3
S23A2_HUMAN
Yolk sac permease-like molecule 2
Homo
<M><M><G><I><G><K><N><T><T><S><K><S><M><E><A><G><S><S><T><E><G><K><Y><E><D><E><A><K><H><P><A><F><F><T><L><P><V><V><I><N><G><G><A><T><S><S><G><E><Q><D><N><E><D><T><E><L><M><A><I><Y><T><T><E><N><G><I><A><E><K><S><S><L><A><E><T><L><D><S><T><G><S><L><D><P><Q><R><S><D><M><I><Y><T><I><E><D><V><P><P><W><Y><L><C><I><F><L><G><L><Q><H><Y><L><T><C><F><S><G><T><I><A><V><P><F><L><L><A><D><A><M><C><V><G><Y><D><Q><W><A><T><S><Q><L><I><G><T><I><F><F><C><V><G><I><T><T><L><L><Q><T><T><F><G><C><R><L><P><L><F><Q><A><S><A><F><A><F><L><A><P><A><R><A><I><L><S><L><D><K><W><K><C><N><T><T><D><V><S><V><A><N><G><T><A><E><L><L><H><T><E><H><I><W><Y><P><R><I><R><E><I><Q><G><A><I><I><M><S><S><L><I><E><V><V><I><G><L><L><G><L><P><G><A><L><L><K><Y><I><G><P><L><T><I><T><P><T><V><A><L><I><G><L><S><G><F><Q><A><A><G><E><R><A><G><K><H><W><G><I><A><M><L><T><I><F><L><V><L><L><F><S><Q><Y><A><R><N><V><K><F><P><L><P><I><Y><K><S><K><K><G><W><T><A><Y><K><L><Q><L><F><K><M><F><P><I><I><L><A><I><L><V><S><W><L><L><C><F><I><F><T><V><T><D><V><F><P><P><D><S><T><K><Y><G><F><Y><A><R><T><D><A><R><Q><G><V><L><L><V><A><P><W><F><K><V><P><Y><P><F><Q><W><G><L><P><T><V><S><A><A><G><V><I><G><M><L><S><A><V><V><A><S><I><I><E><S><I><G><D><Y><Y><A><C><A><R><L><S><C><A><P><P><P><P><I><H><A><I><N><R><G><I><F><V><E><G><L><S><C><V><L><D><G><I><F><G><T><G><N><G><S><T><S><S><S><P><N><I><G><V><L><G><I><T><K><V><G><S><R><R><V><I><Q><C><G><A><A><L><M><L><A><L><G><M><I><G><K><F><S><A><L><F><A><S><L><P><D><P><V><L><G><A><L><F><C><T><L><F><G><M><I><T><A><V><G><L><S><N><L><Q><F><I><D><L><N><S><S><R><N><L><F><V><L><G><F><S><I><F><F><G><L><V><L><P><S><Y><L><R><Q><N><P><L><V><T><G><I><T><G><I><D><Q><V><L><N><V><L><L><T><T><A><M><F><V><G><G><C><V><A><F><I><L><D><N><T><I><P><G><T><P><E><E><R><G><I><R><K><W><K><K><G><V><G><K><G><N><K><S><L><D><G><M><E><S><Y><N><L><P><F><G><M><N><I><I><K><K><Y><R><C><F><S><Y><L><P><I><S><P><T><F><V><G><Y><T><W><K><G><L><R><K><S><D><N><S><R><S><S><D><E><D><S><Q><A><T><G>
Sodium/ascorbate cotransporter . Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate .<BOP>
Q9UGH3
P27469
G0S2_HUMAN
Putative lymphocyte G0/G1 switch gene
Homo
<M><E><T><V><Q><E><L><I><P><L><A><K><E><M><M><A><Q><K><R><K><G><K><M><V><K><L><Y><V><L><G><S><V><L><A><L><F><G><V><V><L><G><L><M><E><T><V><C><S><P><F><T><A><A><R><R><L><R><D><Q><E><A><A><V><A><E><L><Q><A><A><L><E><R><Q><A><L><Q><K><Q><A><L><Q><E><K><G><K><Q><Q><D><T><V><L><G><G><R><A><L><S><N><R><Q><H><A><S>
Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.<BOP>
P27469
Q9H2C8
O51V1_HUMAN
Olfactory receptor OR11-36
Homo
<M><F><L><S><S><R><M><I><T><S><V><S><P><S><T><S><T><N><S><S><F><L><L><T><G><F><S><G><M><E><Q><Q><Y><P><W><L><S><I><P><F><S><S><I><Y><A><M><V><L><L><G><N><C><M><V><L><H><V><I><W><T><E><P><S><L><H><Q><P><M><F><Y><F><L><S><M><L><A><L><T><D><L><C><M><G><L><S><T><V><Y><T><V><L><G><I><L><W><G><I><I><R><E><I><S><L><D><S><C><I><A><Q><S><Y><F><I><H><G><L><S><F><M><E><S><S><V><L><L><T><M><A><F><D><R><Y><I><A><I><C><N><P><L><R><Y><S><S><I><L><T><N><S><R><I><I><K><I><G><L><T><I><I><G><R><S><F><F><F><I><T><P><P><I><I><C><L><K><F><F><N><Y><C><H><F><H><I><L><S><H><S><F><C><L><H><Q><D><L><L><R><L><A><C><S><D><I><R><F><N><S><Y><Y><A><L><M><L><V><I><C><I><L><L><L><D><A><I><L><I><L><F><S><Y><I><L><I><L><K><S><V><L><A><V><A><S><Q><E><E><R><H><K><L><F><Q><T><C><I><S><H><I><C><A><V><L><V><F><Y><I><P><I><I><S><L><T><M><V><H><R><F><G><K><H><L><S><P><V><A><H><V><L><I><G><N><I><Y><I><L><F><P><P><L><M><N><P><I><I><Y><S><V><K><T><Q><Q><I><H><T><R><M><L><R><L><F><S><L><K><R><Y>
Odorant receptor.<BOP>
Q9H2C8
P41970
ELK3_HUMAN
null
Homo
<M><E><S><A><I><T><L><W><Q><F><L><L><Q><L><L><L><D><Q><K><H><E><H><L><I><C><W><T><S><N><D><G><E><F><K><L><L><K><A><E><E><V><A><K><L><W><G><L><R><K><N><K><T><N><M><N><Y><D><K><L><S><R><A><L><R><Y><Y><Y><D><K><N><I><I><K><K><V><I><G><Q><K><F><V><Y><K><F><V><S><F><P><E><I><L><K><M><D><P><H><A><V><E><I><S><R><E><S><L><L><L><Q><D><S><D><C><K><A><S><P><E><G><R><E><A><H><K><H><G><L><A><A><L><R><S><T><S><R><N><E><Y><I><H><S><G><L><Y><S><S><F><T><I><N><S><L><Q><N><P><P><D><A><F><K><A><I><K><T><E><K><L><E><E><P><P><E><D><S><P><P><V><E><E><V><R><T><V><I><R><F><V><T><N><K><T><D><K><H><V><T><R><P><V><V><S><L><P><S><T><S><E><A><A><A><A><S><A><F><L><A><S><S><V><S><A><K><I><S><S><L><M><L><P><N><A><A><S><I><S><S><A><S><P><F><S><S><R><S><P><S><L><S><P><N><S><P><L><P><S><E><H><R><S><L><F><L><E><A><A><C><H><D><S><D><S><L><E><P><L><N><L><S><S><G><S><K><T><K><S><P><S><L><P><P><K><A><K><K><P><K><G><L><E><I><S><A><P><P><L><V><L><S><G><T><D><I><G><S><I><A><L><N><S><P><A><L><P><S><G><S><L><T><P><A><F><F><T><A><Q><T><P><N><G><L><L><L><T><P><S><P><L><L><S><S><I><H><F><W><S><S><L><S><P><V><A><P><L><S><P><A><R><L><Q><G><P><S><T><L><F><Q><F><P><T><L><L><N><G><H><M><P><V><P><I><P><S><L><D><R><A><A><S><P><V><L><L><S><S><N><S><Q><K><S>
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.<BOP>
P41970
O00418
EF2K_HUMAN
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
Homo
<M><A><D><E><D><L><I><F><R><L><E><G><V><D><G><G><Q><S><P><R><A><G><H><D><G><D><S><D><G><D><S><D><D><E><E><G><Y><F><I><C><P><I><T><D><D><P><S><S><N><Q><N><V><N><S><K><V><N><K><Y><Y><S><N><L><T><K><S><E><R><Y><S><S><S><G><S><P><A><N><S><F><H><F><K><E><A><W><K><H><A><I><Q><K><A><K><H><M><P><D><P><W><A><E><F><H><L><E><D><I><A><T><E><R><A><T><R><H><R><Y><N><A><V><T><G><E><W><L><D><D><E><V><L><I><K><M><A><S><Q><P><F><G><R><G><A><M><R><E><C><F><R><T><K><K><L><S><N><F><L><H><A><Q><Q><W><K><G><A><S><N><Y><V><A><K><R><Y><I><E><P><V><D><R><D><V><Y><F><E><D><V><R><L><Q><M><E><A><K><L><W><G><E><E><Y><N><R><H><K><P><P><K><Q><V><D><I><M><Q><M><C><I><I><E><L><K><D><R><P><G><K><P><L><F><H><L><E><H><Y><I><E><G><K><Y><I><K><Y><N><S><N><S><G><F><V><R><D><D><N><I><R><L><T><P><Q><A><F><S><H><F><T><F><E><R><S><G><H><Q><L><I><V><V><D><I><Q><G><V><G><D><L><Y><T><D><P><Q><I><H><T><E><T><G><T><D><F><G><D><G><N><L><G><V><R><G><M><A><L><F><F><Y><S><H><A><C><N><R><I><C><E><S><M><G><L><A><P><F><D><L><S><P><R><E><R><D><A><V><N><Q><N><T><K><L><L><Q><S><A><K><T><I><L><R><G><T><E><E><K><C><G><S><P><Q><V><R><T><L><S><G><S><R><P><P><L><L><R><P><L><S><E><N><S><G><D><E><N><M><S><D><V><T><F><D><S><L><P><S><S><P><S><S><A><T><P><H><S><Q><K><L><D><H><L><H><W><P><V><F><S><D><L><D><N><M><A><S><R><D><H><D><H><L><D><N><H><R><E><S><E><N><S><G><D><S><G><Y><P><S><E><K><R><G><E><L><D><D><P><E><P><R><E><H><G><H><S><Y><S><N><R><K><Y><E><S><D><E><D><S><L><G><S><S><G><R><V><C><V><E><K><W><N><L><L><N><S><S><R><L><H><L><P><R><A><S><A><V><A><L><E><V><Q><R><L><N><A><L><D><L><E><K><K><I><G><K><S><I><L><G><K><V><H><L><A><M><V><R><Y><H><E><G><G><R><F><C><E><K><G><E><E><W><D><Q><E><S><A><V><F><H><L><E><H><A><A><N><L><G><E><L><E><A><I><V><G><L><G><L><M><Y><S><Q><L><P><H><H><I><L><A><D><V><S><L><K><E><T><E><E><N><K><T><K><G><F><D><Y><L><L><K><A><A><E><A><G><D><R><Q><S><M><I><L><V><A><R><A><F><D><S><G><Q><N><L><S><P><D><R><C><Q><D><W><L><E><A><L><H><W><Y><N><T><A><L><E><M><T><D><C><D><E><G><G><E><Y><D><G><M><Q><D><E><P><R><Y><M><M><L><A><R><E><A><E><M><L><F><T><G><G><Y><G><L><E><K><D><P><Q><R><S><G><D><L><Y><T><Q><A><A><E><A><A><M><E><A><M><K><G><R><L><A><N><Q><Y><Y><Q><K><A><E><E><A><W><A><Q><M><E><E>
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.<BOP>
O00418
O14949
QCR8_HUMAN
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Homo
<M><G><R><E><F><G><N><L><T><R><M><R><H><V><I><S><Y><S><L><S><P><F><E><Q><R><A><Y><P><H><V><F><T><K><G><I><P><N><V><L><R><R><I><R><E><S><F><F><R><V><V><P><Q><F><V><V><F><Y><L><I><Y><T><W><G><T><E><E><F><E><R><S><K><R><K><N><P><A><A><Y><E><N><D><K>
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.<BOP>
O14949
Q9BST9
RTKN_HUMAN
Rhotekin
Homo
<M><F><S><R><N><H><R><S><R><V><T><V><A><R><G><S><A><L><E><M><E><F><K><R><G><R><F><R><L><S><L><F><S><D><L><P><E><D><T><E><L><Q><R><K><L><D><H><E><I><R><M><R><E><G><A><C><K><L><L><A><A><C><S><Q><R><E><Q><A><L><E><A><T><K><S><L><L><V><C><N><S><R><I><L><S><Y><M><G><E><L><Q><R><R><K><E><A><Q><V><L><G><K><T><S><R><R><P><S><D><S><G><P><P><A><E><R><S><P><C><R><G><R><V><C><I><S><D><L><R><I><P><L><M><W><K><D><T><E><Y><F><K><N><K><G><D><L><H><R><W><A><V><F><L><L><L><Q><L><G><E><H><I><Q><D><T><E><M><I><L><V><D><R><T><L><T><D><I><S><F><Q><S><N><V><L><F><A><E><A><G><P><D><F><E><L><R><L><E><L><Y><G><A><C><V><E><E><E><G><A><L><T><G><G><P><K><R><L><A><T><K><L><S><S><S><L><G><R><S><S><G><R><R><V><R><A><S><L><D><S><A><G><G><S><G><S><S><P><I><L><L><P><T><P><V><V><G><G><P><R><Y><H><L><L><A><H><T><T><L><T><L><A><A><V><Q><D><G><F><R><T><H><D><L><T><L><A><S><H><E><E><N><P><A><W><L><P><L><Y><G><S><V><C><C><R><L><A><A><Q><P><L><C><M><T><Q><P><T><A><S><G><T><L><R><V><Q><Q><A><G><E><M><Q><N><W><A><Q><V><H><G><V><L><K><G><T><N><L><F><C><Y><R><Q><P><E><D><A><D><T><G><E><E><P><L><L><T><I><A><V><N><K><E><T><R><V><R><A><G><E><L><D><Q><A><L><G><R><P><F><T><L><S><I><S><N><Q><Y><G><D><D><E><V><T><H><T><L><Q><T><E><S><R><E><A><L><Q><S><W><M><E><A><L><W><Q><L><F><F><D><M><S><Q><W><K><Q><C><C><D><E><I><M><K><I><E><T><P><A><P><R><K><P><P><Q><A><L><A><K><Q><G><S><L><Y><H><E><M><A><I><E><P><L><D><D><I><A><A><V><T><D><I><L><T><Q><R><E><G><A><R><L><E><T><P><P><P><W><L><A><M><F><T><D><Q><P><A><L><P><N><P><C><S><P><A><S><V><A><P><A><P><D><W><T><H><P><L><P><W><G><R><P><R><T><F><S><L><D><A><V><P><P><D><H><S><P><R><A><R><S><V><A><P><L><P><P><Q><R><S><P><R><T><R><G><L><C><S><K><G><Q><P><R><T><W><L><Q><S><P><V>
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.<BOP>
Q9BST9
Q92876
KLK6_HUMAN
Zyme
Homo
<M><K><K><L><M><V><V><L><S><L><I><A><A><A><W><A><E><E><Q><N><K><L><V><H><G><G><P><C><D><K><T><S><H><P><Y><Q><A><A><L><Y><T><S><G><H><L><L><C><G><G><V><L><I><H><P><L><W><V><L><T><A><A><H><C><K><K><P><N><L><Q><V><F><L><G><K><H><N><L><R><Q><R><E><S><S><Q><E><Q><S><S><V><V><R><A><V><I><H><P><D><Y><D><A><A><S><H><D><Q><D><I><M><L><L><R><L><A><R><P><A><K><L><S><E><L><I><Q><P><L><P><L><E><R><D><C><S><A><N><T><T><S><C><H><I><L><G><W><G><K><T><A><D><G><D><F><P><D><T><I><Q><C><A><Y><I><H><L><V><S><R><E><E><C><E><H><A><Y><P><G><Q><I><T><Q><N><M><L><C><A><G><D><E><K><Y><G><K><D><S><C><Q><G><D><S><G><G><P><L><V><C><G><D><H><L><R><G><L><V><S><W><G><N><I><P><C><G><S><K><E><K><P><G><V><Y><T><N><V><C><R><Y><T><N><W><I><Q><K><T><I><Q><A><K>
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<BOP>
Q92876
Q9H8G1
ZN430_HUMAN
Zinc finger protein 430
Homo
<M><E><N><L><K><S><G><V><Y><P><L><K><E><A><S><G><C><P><G><A><D><R><N><L><L><V><Y><S><F><Y><E><K><G><P><L><T><F><R><D><V><A><I><E><F><S><L><E><E><W><Q><C><L><D><T><A><Q><Q><D><L><Y><R><K><V><M><L><E><N><Y><R><N><L><V><F><L><A><G><I><A><V><S><K><P><D><L><I><T><C><L><E><Q><G><K><E><P><W><N><M><K><R><H><A><M><V><D><Q><P><P><V><T><Y><S><H><F><A><Q><D><L><W><P><E><Q><G><I><K><D><S><F><Q><E><V><I><L><R><R><Y><G><K><C><G><H><E><D><L><Q><L><R><T><G><C><K><S><V><D><E><C><N><L><H><K><E><C><Y><D><E><L><N><Q><C><L><T><T><T><Q><S><E><I><F><Q><Y><D><K><Y><V><N><V><F><Y><K><F><S><N><P><N><I><Q><K><I><R><H><T><G><K><K><P><F><K><C><K><K><C><D><K><S><F><C><M><L><L><H><L><T><Q><H><K><R><I><H><I><R><E><N><S><Y><Q><C><E><E><C><G><K><V><F><N><W><F><S><T><L><T><R><H><R><R><I><H><T><G><E><K><P><Y><K><C><E><Q><C><G><K><A><F><K><Q><S><S><T><L><T><T><H><K><I><I><H><T><G><E><K><P><Y><R><C><E><E><C><G><K><T><F><N><R><S><S><H><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><R><C><E><E><C><G><R><A><F><N><R><S><S><H><L><T><T><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><T><L><T><T><H><K><I><I><H><A><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><Y><R><F><S><Y><L><T><K><H><K><I><I><H><T><G><E><K><F><Y><K><C><E><E><C><G><K><G><F><N><W><S><S><T><L><T><K><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><Q><C><G><K><A><F><N><E><S><S><N><L><T><A><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><P><K><L><T><A><H><K><V><I><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><F><S><N><L><T><K><H><K><I><T><H><I><G><D><T><S><Y><K><Y><L><E><C><D><K><A><F><S><Q><S><S><T><L><T><K><H><K><V><I><H><T><G><E><K><P><Y><N><C><E><E><Y><G><K><A><F><N><Q><S><S><N><L><I><E><Q><S><N><S><Y><W><R><E><T><L><Q><M>
May be involved in transcriptional regulation.<BOP>
Q9H8G1
Q9H772
GREM2_HUMAN
Protein related to DAN and cerberus
Homo
<M><F><W><K><L><S><L><S><L><F><L><V><A><V><L><V><K><V><A><E><A><R><K><N><R><P><A><G><A><I><P><S><P><Y><K><D><G><S><S><N><N><S><E><R><W><Q><H><Q><I><K><E><V><L><A><S><S><Q><E><A><L><V><V><T><E><R><K><Y><L><K><S><D><W><C><K><T><Q><P><L><R><Q><T><V><S><E><E><G><C><R><S><R><T><I><L><N><R><F><C><Y><G><Q><C><N><S><F><Y><I><P><R><H><V><K><K><E><E><E><S><F><Q><S><C><A><F><C><K><P><Q><R><V><T><S><V><L><V><E><L><E><C><P><G><L><D><P><P><F><R><L><K><K><I><Q><K><V><K><Q><C><R><C><M><S><V><N><L><S><D><S><D><K><Q>
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.<BOP>
Q9H772
P37235
HPCL1_HUMAN
Visinin-like protein 3
Homo
<M><G><K><Q><N><S><K><L><R><P><E><V><L><Q><D><L><R><E><N><T><E><F><T><D><H><E><L><Q><E><W><Y><K><G><F><L><K><D><C><P><T><G><H><L><T><V><D><E><F><K><K><I><Y><A><N><F><F><P><Y><G><D><A><S><K><F><A><E><H><V><F><R><T><F><D><T><N><G><D><G><T><I><D><F><R><E><F><I><I><A><L><S><V><T><S><R><G><K><L><E><Q><K><L><K><W><A><F><S><M><Y><D><L><D><G><N><G><Y><I><S><R><S><E><M><L><E><I><V><Q><A><I><Y><K><M><V><S><S><V><M><K><M><P><E><D><E><S><T><P><E><K><R><T><D><K><I><F><R><Q><M><D><T><N><N><D><G><K><L><S><L><E><E><F><I><R><G><A><K><S><D><P><S><I><V><R><L><L><Q><C><D><P><S><S><A><S><Q><F>
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.<BOP>
P37235
Q9Y3A0
COQ4_HUMAN
Coenzyme Q biosynthesis protein 4 homolog
Homo
<M><A><T><L><L><R><P><V><L><R><R><L><C><G><L><P><G><L><Q><R><P><A><A><E><M><P><L><R><A><R><S><D><G><A><G><P><L><Y><S><H><H><L><P><T><S><P><L><Q><K><G><L><L><A><A><G><S><A><A><M><A><L><Y><N><P><Y><R><H><D><M><V><A><V><L><G><E><T><T><G><H><R><T><L><K><V><L><R><D><Q><M><R><R><D><P><E><G><A><Q><I><L><Q><E><R><P><R><I><S><T><S><T><L><D><L><G><K><L><Q><S><L><P><E><G><S><L><G><R><E><Y><L><R><F><L><D><V><N><R><V><S><P><D><T><R><A><P><T><R><F><V><D><D><E><E><L><A><Y><V><I><Q><R><Y><R><E><V><H><D><M><L><H><T><L><L><G><M><P><T><N><I><L><G><E><I><V><V><K><W><F><E><A><V><Q><T><G><L><P><M><C><I><L><G><A><F><F><G><P><I><R><L><G><A><Q><S><L><Q><V><L><V><S><E><L><I><P><W><A><V><Q><N><G><R><R><A><P><C><V><L><N><L><Y><Y><E><R><R><W><E><Q><S><L><R><A><L><R><E><E><L><G><I><T><A><P><P><M><H><V><Q><G><L><A>
Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.<BOP>
Q9Y3A0
O76031
CLPX_HUMAN
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Homo
<M><P><S><C><G><A><C><T><C><G><A><A><A><V><R><L><I><T><S><S><L><A><S><A><Q><R><G><I><S><G><G><R><I><H><M><S><V><L><G><R><L><G><T><F><E><T><Q><I><L><Q><R><A><P><L><R><S><F><T><E><T><P><A><Y><F><A><S><K><D><G><I><S><K><D><G><S><G><D><G><N><K><K><S><A><S><E><G><S><S><K><K><S><G><S><G><N><S><G><K><G><G><N><Q><L><R><C><P><K><C><G><D><L><C><T><H><V><E><T><F><V><S><S><T><R><F><V><K><C><E><K><C><H><H><F><F><V><V><L><S><E><A><D><S><K><K><S><I><I><K><E><P><E><S><A><A><E><A><V><K><L><A><F><Q><Q><K><P><P><P><P><P><K><K><I><Y><N><Y><L><D><K><Y><V><V><G><Q><S><F><A><K><K><V><L><S><V><A><V><Y><N><H><Y><K><R><I><Y><N><N><I><P><A><N><L><R><Q><Q><A><E><V><E><K><Q><T><S><L><T><P><R><E><L><E><I><R><R><R><E><D><E><Y><R><F><T><K><L><L><Q><I><A><G><I><S><P><H><G><N><A><L><G><A><S><M><Q><Q><Q><V><N><Q><Q><I><P><Q><E><K><R><G><G><E><V><L><D><S><S><H><D><D><I><K><L><E><K><S><N><I><L><L><L><G><P><T><G><S><G><K><T><L><L><A><Q><T><L><A><K><C><L><D><V><P><F><A><I><C><D><C><T><T><L><T><Q><A><G><Y><V><G><E><D><I><E><S><V><I><A><K><L><L><Q><D><A><N><Y><N><V><E><K><A><Q><Q><G><I><V><F><L><D><E><V><D><K><I><G><S><V><P><G><I><H><Q><L><R><D><V><G><G><E><G><V><Q><Q><G><L><L><K><L><L><E><G><T><I><V><N><V><P><E><K><N><S><R><K><L><R><G><E><T><V><Q><V><D><T><T><N><I><L><F><V><A><S><G><A><F><N><G><L><D><R><I><I><S><R><R><K><N><E><K><Y><L><G><F><G><T><P><S><N><L><G><K><G><R><R><A><A><A><A><A><D><L><A><N><R><S><G><E><S><N><T><H><Q><D><I><E><E><K><D><R><L><L><R><H><V><E><A><R><D><L><I><E><F><G><M><I><P><E><F><V><G><R><L><P><V><V><V><P><L><H><S><L><D><E><K><T><L><V><Q><I><L><T><E><P><R><N><A><V><I><P><Q><Y><Q><A><L><F><S><M><D><K><C><E><L><N><V><T><E><D><A><L><K><A><I><A><R><L><A><L><E><R><K><T><G><A><R><G><L><R><S><I><M><E><K><L><L><L><E><P><M><F><E><V><P><N><S><D><I><V><C><V><E><V><D><K><E><V><V><E><G><K><K><E><P><G><Y><I><R><A><P><T><K><E><S><S><E><E><E><Y><D><S><G><V><E><E><E><G><W><P><R><Q><A><D><A><A><N><S>
ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP . Targets specific substrates for degradation by the Clp complex . Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure . ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis . Important for efficient erythropoiesis through up-regulation of heme biosynthesis .<BOP>
O76031
O43405
COCH_HUMAN
COCH-5B2
Homo
<M><S><A><A><W><I><P><A><L><G><L><G><V><C><L><L><L><L><P><G><P><A><G><S><E><G><A><A><P><I><A><I><T><C><F><T><R><G><L><D><I><R><K><E><K><A><D><V><L><C><P><G><G><C><P><L><E><E><F><S><V><Y><G><N><I><V><Y><A><S><V><S><S><I><C><G><A><A><V><H><R><G><V><I><S><N><S><G><G><P><V><R><V><Y><S><L><P><G><R><E><N><Y><S><S><V><D><A><N><G><I><Q><S><Q><M><L><S><R><W><S><A><S><F><T><V><T><K><G><K><S><S><T><Q><E><A><T><G><Q><A><V><S><T><A><H><P><P><T><G><K><R><L><K><K><T><P><E><K><K><T><G><N><K><D><C><K><A><D><I><A><F><L><I><D><G><S><F><N><I><G><Q><R><R><F><N><L><Q><K><N><F><V><G><K><V><A><L><M><L><G><I><G><T><E><G><P><H><V><G><L><V><Q><A><S><E><H><P><K><I><E><F><Y><L><K><N><F><T><S><A><K><D><V><L><F><A><I><K><E><V><G><F><R><G><G><N><S><N><T><G><K><A><L><K><H><T><A><Q><K><F><F><T><V><D><A><G><V><R><K><G><I><P><K><V><V><V><V><F><I><D><G><W><P><S><D><D><I><E><E><A><G><I><V><A><R><E><F><G><V><N><V><F><I><V><S><V><A><K><P><I><P><E><E><L><G><M><V><Q><D><V><T><F><V><D><K><A><V><C><R><N><N><G><F><F><S><Y><H><M><P><N><W><F><G><T><T><K><Y><V><K><P><L><V><Q><K><L><C><T><H><E><Q><M><M><C><S><K><T><C><Y><N><S><V><N><I><A><F><L><I><D><G><S><S><S><V><G><D><S><N><F><R><L><M><L><E><F><V><S><N><I><A><K><T><F><E><I><S><D><I><G><A><K><I><A><A><V><Q><F><T><Y><D><Q><R><T><E><F><S><F><T><D><Y><S><T><K><E><N><V><L><A><V><I><R><N><I><R><Y><M><S><G><G><T><A><T><G><D><A><I><S><F><T><V><R><N><V><F><G><P><I><R><E><S><P><N><K><N><F><L><V><I><V><T><D><G><Q><S><Y><D><D><V><Q><G><P><A><A><A><A><H><D><A><G><I><T><I><F><S><V><G><V><A><W><A><P><L><D><D><L><K><D><M><A><S><K><P><K><E><S><H><A><F><F><T><R><E><F><T><G><L><E><P><I><V><S><D><V><I><R><G><I><C><R><D><F><L><E><S><Q><Q>
Plays a role in the control of cell shape and motility in the trabecular meshwork.<BOP>
O43405
P32241
VIPR1_HUMAN
VPAC1
Homo
<M><R><P><P><S><P><L><P><A><R><W><L><C><V><L><A><G><A><L><A><W><A><L><G><P><A><G><G><Q><A><A><R><L><Q><E><E><C><D><Y><V><Q><M><I><E><V><Q><H><K><Q><C><L><E><E><A><Q><L><E><N><E><T><I><G><C><S><K><M><W><D><N><L><T><C><W><P><A><T><P><R><G><Q><V><V><V><L><A><C><P><L><I><F><K><L><F><S><S><I><Q><G><R><N><V><S><R><S><C><T><D><E><G><W><T><H><L><E><P><G><P><Y><P><I><A><C><G><L><D><D><K><A><A><S><L><D><E><Q><Q><T><M><F><Y><G><S><V><K><T><G><Y><T><I><G><Y><G><L><S><L><A><T><L><L><V><A><T><A><I><L><S><L><F><R><K><L><H><C><T><R><N><Y><I><H><M><H><L><F><I><S><F><I><L><R><A><A><A><V><F><I><K><D><L><A><L><F><D><S><G><E><S><D><Q><C><S><E><G><S><V><G><C><K><A><A><M><V><F><F><Q><Y><C><V><M><A><N><F><F><W><L><L><V><E><G><L><Y><L><Y><T><L><L><A><V><S><F><F><S><E><R><K><Y><F><W><G><Y><I><L><I><G><W><G><V><P><S><T><F><T><M><V><W><T><I><A><R><I><H><F><E><D><Y><G><C><W><D><T><I><N><S><S><L><W><W><I><I><K><G><P><I><L><T><S><I><L><V><N><F><I><L><F><I><C><I><I><R><I><L><L><Q><K><L><R><P><P><D><I><R><K><S><D><S><S><P><Y><S><R><L><A><R><S><T><L><L><L><I><P><L><F><G><V><H><Y><I><M><F><A><F><F><P><D><N><F><K><P><E><V><K><M><V><F><E><L><V><V><G><S><F><Q><G><F><V><V><A><I><L><Y><C><F><L><N><G><E><V><Q><A><E><L><R><R><K><W><R><R><W><H><L><Q><G><V><L><G><W><N><P><K><Y><R><H><P><S><G><G><S><N><G><A><T><C><S><T><Q><V><S><M><L><T><R><V><S><P><G><A><R><R><S><S><S><F><Q><A><E><V><S><L><V>
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.<BOP>
P32241
Q9HCJ2
LRC4C_HUMAN
Netrin-G1 ligand
Homo
<M><L><N><K><M><T><L><H><P><Q><Q><I><M><I><G><P><R><F><N><R><A><L><F><D><P><L><L><V><V><L><L><A><L><Q><L><L><V><V><A><G><L><V><R><A><Q><T><C><P><S><V><C><S><C><S><N><Q><F><S><K><V><I><C><V><R><K><N><L><R><E><V><P><D><G><I><S><T><N><T><R><L><L><N><L><H><E><N><Q><I><Q><I><I><K><V><N><S><F><K><H><L><R><H><L><E><I><L><Q><L><S><R><N><H><I><R><T><I><E><I><G><A><F><N><G><L><A><N><L><N><T><L><E><L><F><D><N><R><L><T><T><I><P><N><G><A><F><V><Y><L><S><K><L><K><E><L><W><L><R><N><N><P><I><E><S><I><P><S><Y><A><F><N><R><I><P><S><L><R><R><L><D><L><G><E><L><K><R><L><S><Y><I><S><E><G><A><F><E><G><L><S><N><L><R><Y><L><N><L><A><M><C><N><L><R><E><I><P><N><L><T><P><L><I><K><L><D><E><L><D><L><S><G><N><H><L><S><A><I><R><P><G><S><F><Q><G><L><M><H><L><Q><K><L><W><M><I><Q><S><Q><I><Q><V><I><E><R><N><A><F><D><N><L><Q><S><L><V><E><I><N><L><A><H><N><N><L><T><L><L><P><H><D><L><F><T><P><L><H><H><L><E><R><I><H><L><H><H><N><P><W><N><C><N><C><D><I><L><W><L><S><W><W><I><K><D><M><A><P><S><N><T><A><C><C><A><R><C><N><T><P><P><N><L><K><G><R><Y><I><G><E><L><D><Q><N><Y><F><T><C><Y><A><P><V><I><V><E><P><P><A><D><L><N><V><T><E><G><M><A><A><E><L><K><C><R><A><S><T><S><L><T><S><V><S><W><I><T><P><N><G><T><V><M><T><H><G><A><Y><K><V><R><I><A><V><L><S><D><G><T><L><N><F><T><N><V><T><V><Q><D><T><G><M><Y><T><C><M><V><S><N><S><V><G><N><T><T><A><S><A><T><L><N><V><T><A><A><T><T><T><P><F><S><Y><F><S><T><V><T><V><E><T><M><E><P><S><Q><D><E><A><R><T><T><D><N><N><V><G><P><T><P><V><V><D><W><E><T><T><N><V><T><T><S><L><T><P><Q><S><T><R><S><T><E><K><T><F><T><I><P><V><T><D><I><N><S><G><I><P><G><I><D><E><V><M><K><T><T><K><I><I><I><G><C><F><V><A><I><T><L><M><A><A><V><M><L><V><I><F><Y><K><M><R><K><Q><H><H><R><Q><N><H><H><A><P><T><R><T><V><E><I><I><N><V><D><D><E><I><T><G><D><T><P><M><E><S><H><L><P><M><P><A><I><E><H><E><H><L><N><H><Y><N><S><Y><K><S><P><F><N><H><T><T><T><V><N><T><I><N><S><I><H><S><S><V><H><E><P><L><L><I><R><M><N><S><K><D><N><V><Q><E><T><Q><I>
May promote neurite outgrowth of developing thalamic neurons.<BOP>
Q9HCJ2
Q9UJY1
HSPB8_HUMAN
Small stress protein-like protein HSP22
Homo
<M><A><D><G><Q><M><P><F><S><C><H><Y><P><S><R><L><R><R><D><P><F><R><D><S><P><L><S><S><R><L><L><D><D><G><F><G><M><D><P><F><P><D><D><L><T><A><S><W><P><D><W><A><L><P><R><L><S><S><A><W><P><G><T><L><R><S><G><M><V><P><R><G><P><T><A><T><A><R><F><G><V><P><A><E><G><R><T><P><P><P><F><P><G><E><P><W><K><V><C><V><N><V><H><S><F><K><P><E><E><L><M><V><K><T><K><D><G><Y><V><E><V><S><G><K><H><E><E><K><Q><Q><E><G><G><I><V><S><K><N><F><T><K><K><I><Q><L><P><A><E><V><D><P><V><T><V><F><A><S><L><S><P><E><G><L><L><I><I><E><A><P><Q><V><P><P><Y><S><T><F><G><E><S><S><F><N><N><E><L><P><Q><D><S><Q><E><V><T><C><T>
Displays temperature-dependent chaperone activity.<BOP>
Q9UJY1
Q9BTD3
TM121_HUMAN
Transmembrane protein 121
Homo
<M><V><L><P><P><P><D><R><R><H><V><C><L><T><T><L><V><I><M><G><S><M><A><V><M><D><A><Y><L><V><E><Q><N><Q><G><P><R><K><I><G><V><C><I><I><V><L><V><G><D><V><C><F><L><L><V><L><R><Y><V><A><V><W><V><G><A><E><V><R><T><A><K><R><G><Y><A><M><I><L><W><F><L><Y><I><F><V><L><E><I><K><L><Y><F><I><F><Q><N><Y><K><A><A><R><R><G><A><A><D><P><V><A><R><K><A><L><T><L><L><L><S><V><C><V><P><G><L><F><L><L><L><V><A><L><D><R><M><E><Y><V><R><T><F><R><K><R><E><D><L><R><G><R><L><F><W><V><A><L><D><L><L><D><L><L><D><M><Q><A><S><L><W><E><P><P><R><S><G><L><P><L><W><A><E><G><L><T><F><F><Y><C><Y><M><L><L><L><V><L><P><C><V><A><L><S><E><V><S><M><Q><G><E><H><I><A><P><Q><K><M><M><L><Y><P><V><L><S><L><A><T><V><N><V><V><A><V><L><A><R><A><A><N><M><A><L><F><R><D><S><R><V><S><A><I><F><V><G><K><N><V><V><A><L><A><T><K><A><C><T><F><L><E><Y><R><R><Q><V><R><D><F><P><P><P><A><L><S><L><E><L><Q><P><P><P><P><Q><R><N><S><V><P><P><P><P><P><P><L><H><G><P><P><G><R><P><H><M><S><S><P><T><R><D><P><L><D><T>
May play a role in MAPK signaling.<BOP>
Q9BTD3
Q9UN88
GBRT_HUMAN
GABA(A) receptor subunit theta
Homo
<M><G><I><R><G><M><L><R><A><A><V><I><L><L><L><I><R><T><W><L><A><E><G><N><Y><P><S><P><I><P><K><F><H><F><E><F><S><S><A><V><P><E><V><V><L><N><L><F><N><C><K><N><C><A><N><E><A><V><V><Q><K><I><L><D><R><V><L><S><R><Y><D><V><R><L><R><P><N><F><G><G><A><P><V><P><V><R><I><S><I><Y><V><T><S><I><E><Q><I><S><E><M><N><M><D><Y><T><I><T><M><F><F><H><Q><T><W><K><D><S><R><L><A><Y><Y><E><T><T><L><N><L><T><L><D><Y><R><M><H><E><K><L><W><V><P><D><C><Y><F><L><N><S><K><D><A><F><V><H><D><V><T><V><E><N><R><V><F><Q><L><H><P><D><G><T><V><R><Y><G><I><R><L><T><T><T><A><A><C><S><L><D><L><H><K><F><P><M><D><K><Q><A><C><N><L><V><V><E><S><Y><G><Y><T><V><E><D><I><I><L><F><W><D><D><N><G><N><A><I><H><M><T><E><E><L><H><I><P><Q><F><T><F><L><G><R><T><I><T><S><K><E><V><Y><F><Y><T><G><S><Y><I><R><L><I><L><K><F><Q><V><Q><R><E><V><N><S><Y><L><V><Q><V><Y><W><P><T><V><L><T><T><I><T><S><W><I><S><F><W><M><N><Y><D><S><S><A><A><R><V><T><I><G><L><T><S><M><L><I><L><T><T><I><D><S><H><L><R><D><K><L><P><N><I><S><C><I><K><A><I><D><I><Y><I><L><V><C><L><F><F><V><F><L><S><L><L><E><Y><V><Y><I><N><Y><L><F><Y><S><R><G><P><R><R><Q><P><R><R><H><R><R><P><R><R><V><I><A><R><Y><R><Y><Q><Q><V><V><V><G><N><V><Q><D><G><L><I><N><V><E><D><G><V><S><S><L><P><I><T><P><A><Q><A><P><L><A><S><P><E><S><L><G><S><L><T><S><T><S><E><Q><A><Q><L><A><T><S><E><S><L><S><P><L><T><S><L><S><G><Q><A><P><L><A><T><G><E><S><L><S><D><L><P><S><T><S><E><Q><A><R><H><S><Y><G><V><R><F><N><G><F><Q><A><D><D><S><I><I><P><T><E><I><R><N><R><V><E><A><H><G><H><G><V><T><H><D><H><E><D><S><N><E><S><L><S><S><D><E><R><H><G><H><G><P><S><G><K><P><M><L><H><H><G><E><K><G><V><Q><E><A><G><W><D><L><D><D><N><N><D><K><S><D><C><L><A><I><K><E><Q><F><K><C><D><T><N><S><T><W><G><L><N><D><D><E><L><M><A><H><G><Q><E><K><D><S><S><S><E><S><E><D><S><C><P><P><S><P><G><C><S><F><T><E><G><F><S><F><D><L><F><N><P><D><Y><V><P><K><V><D><K><W><S><R><F><L><F><P><L><A><F><G><L><F><N><I><V><Y><W><V><Y><H><M><Y>
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.<BOP>
Q9UN88
Q52LJ0
FA98B_HUMAN
Protein FAM98B
Homo
<M><R><G><P><E><P><G><P><Q><P><T><M><E><G><D><V><L><D><T><L><E><A><L><G><Y><K><G><P><L><L><E><E><Q><A><L><T><K><A><A><E><G><G><L><S><S><P><E><F><S><E><L><C><I><W><L><G><S><Q><I><K><S><L><C><N><L><E><E><S><I><T><S><A><G><R><D><D><L><E><S><F><Q><L><E><I><S><G><F><L><K><E><M><A><C><P><Y><S><V><L><I><S><G><D><I><K><D><R><L><K><K><K><E><D><C><L><K><L><L><L><F><L><S><T><E><L><Q><A><S><Q><I><L><Q><N><K><K><H><K><N><S><Q><L><D><K><N><S><E><V><Y><Q><E><V><Q><A><M><F><D><T><L><G><I><P><K><S><T><T><S><D><I><P><H><M><L><N><Q><V><E><S><K><V><K><D><I><L><S><K><V><Q><K><N><H><V><G><K><P><L><L><K><M><D><L><N><S><E><Q><A><E><Q><L><E><R><I><N><D><A><L><S><C><E><Y><E><C><R><R><R><M><L><M><K><R><L><D><V><T><V><Q><S><F><G><W><S><D><R><A><K><V><K><T><D><D><I><A><R><I><Y><Q><P><K><R><Y><A><L><S><P><K><T><T><I><T><M><A><H><L><L><A><A><R><E><D><L><S><K><I><I><R><T><S><S><G><T><S><R><E><K><T><A><C><A><I><N><K><V><L><M><G><R><V><P><D><R><G><G><R><P><N><E><I><E><P><P><P><P><E><M><P><P><W><Q><K><R><Q><E><G><G><G><G><R><G><G><W><G><G><G><G><G><G><G><G><R><G><G><G><G><G><G><G><G><R><G><G><W><G><G><G><G><G><G><W><G><G><G><G><G><G><G><G><G><W><G><G><G><G><G><G><G><R><G><G><F><Q><G><R><G><D><Y><G><G><R><G><G><Y><G><G><R><G><G><Y><G><G><R><G><Y><G><D><P><Y><G><G><G><G><G><G><G><G><G><G><G><G><G><G><G><Y><R><R><Y>
Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation . Promotes colorectal cancer cell malignancy .<BOP>
Q52LJ0
Q6IQ49
SDE2_HUMAN
Replication stress response regulator SDE2
Homo
<M><A><E><A><A><A><L><V><W><I><R><G><P><G><F><G><C><K><A><V><R><C><A><S><G><R><C><T><V><R><D><F><I><H><R><H><C><Q><D><Q><N><V><P><V><E><N><F><F><V><K><C><N><G><A><L><I><N><T><S><D><T><V><Q><H><G><A><V><Y><S><L><E><P><R><L><C><G><G><K><G><G><F><G><S><M><L><R><A><L><G><A><Q><I><E><K><T><T><N><R><E><A><C><R><D><L><S><G><R><R><L><R><D><V><N><H><E><K><A><M><A><E><W><V><K><Q><Q><A><E><R><E><A><E><K><E><Q><K><R><L><E><R><L><Q><R><K><L><V><E><P><K><H><C><F><T><S><P><D><Y><Q><Q><Q><C><H><E><M><A><E><R><L><E><D><S><V><L><K><G><M><Q><A><A><S><S><K><M><V><S><A><E><I><S><E><N><R><K><R><Q><W><P><T><K><S><Q><T><D><R><G><A><S><A><G><K><R><R><C><F><W><L><G><M><E><G><L><E><T><A><E><G><S><N><S><E><S><S><D><D><D><S><E><E><A><P><S><T><S><G><M><G><F><H><A><P><K><I><G><S><N><G><V><E><M><A><A><K><F><P><S><G><S><Q><R><A><R><V><V><N><T><D><H><G><S><P><E><Q><L><Q><I><P><V><T><D><S><G><R><H><I><L><E><D><S><C><A><E><L><G><E><S><K><E><H><M><E><S><R><M><V><T><E><T><E><E><T><Q><E><K><K><A><E><S><K><E><P><I><E><E><E><P><T><G><A><G><L><N><K><D><K><E><T><E><E><R><T><D><G><E><R><V><A><E><V><A><P><E><E><R><E><N><V><A><V><A><K><L><Q><E><S><Q><P><G><N><A><V><I><D><K><E><T><I><D><L><L><A><F><T><S><V><A><E><L><E><L><L><G><L><E><K><L><K><C><E><L><M><A><L><G><L><K><C><G><G><T><L><Q><E><R><A><A><R><L><F><S><V><R><G><L><A><K><E><Q><I><D><P><A><L><F><A><K><P><L><K><G><K><K><K>
Involved in both DNA replication and cell cycle control . Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner . Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression .<BOP>
Q6IQ49
P05787
K2C8_HUMAN
Type-II keratin Kb8
Homo
<M><S><I><R><V><T><Q><K><S><Y><K><V><S><T><S><G><P><R><A><F><S><S><R><S><Y><T><S><G><P><G><S><R><I><S><S><S><S><F><S><R><V><G><S><S><N><F><R><G><G><L><G><G><G><Y><G><G><A><S><G><M><G><G><I><T><A><V><T><V><N><Q><S><L><L><S><P><L><V><L><E><V><D><P><N><I><Q><A><V><R><T><Q><E><K><E><Q><I><K><T><L><N><N><K><F><A><S><F><I><D><K><V><R><F><L><E><Q><Q><N><K><M><L><E><T><K><W><S><L><L><Q><Q><Q><K><T><A><R><S><N><M><D><N><M><F><E><S><Y><I><N><N><L><R><R><Q><L><E><T><L><G><Q><E><K><L><K><L><E><A><E><L><G><N><M><Q><G><L><V><E><D><F><K><N><K><Y><E><D><E><I><N><K><R><T><E><M><E><N><E><F><V><L><I><K><K><D><V><D><E><A><Y><M><N><K><V><E><L><E><S><R><L><E><G><L><T><D><E><I><N><F><L><R><Q><L><Y><E><E><E><I><R><E><L><Q><S><Q><I><S><D><T><S><V><V><L><S><M><D><N><S><R><S><L><D><M><D><S><I><I><A><E><V><K><A><Q><Y><E><D><I><A><N><R><S><R><A><E><A><E><S><M><Y><Q><I><K><Y><E><E><L><Q><S><L><A><G><K><H><G><D><D><L><R><R><T><K><T><E><I><S><E><M><N><R><N><I><S><R><L><Q><A><E><I><E><G><L><K><G><Q><R><A><S><L><E><A><A><I><A><D><A><E><Q><R><G><E><L><A><I><K><D><A><N><A><K><L><S><E><L><E><A><A><L><Q><R><A><K><Q><D><M><A><R><Q><L><R><E><Y><Q><E><L><M><N><V><K><L><A><L><D><I><E><I><A><T><Y><R><K><L><L><E><G><E><E><S><R><L><E><S><G><M><Q><N><M><S><I><H><T><K><T><T><S><G><Y><A><G><G><L><S><S><A><Y><G><G><L><T><S><P><G><L><S><Y><S><L><G><S><S><F><G><S><G><A><G><S><S><S><F><S><R><T><S><S><S><R><A><V><V><V><K><K><I><E><T><R><D><G><K><L><V><S><E><S><S><D><V><L><P><K>
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.<BOP>
P05787
Q86XJ0
CAHM3_HUMAN
Protein A
Homo
<M><D><K><F><R><M><L><F><Q><H><F><Q><S><S><S><E><S><V><M><N><G><I><C><L><L><L><A><A><V><T><V><K><L><Y><S><S><F><D><F><N><C><P><C><L><V><H><Y><N><A><L><Y><G><L><G><L><L><L><T><P><P><L><A><L><F><L><C><G><L><L><A><N><R><Q><S><V><V><M><V><E><E><W><R><R><P><A><G><H><R><R><K><D><P><G><I><I><R><Y><M><C><S><S><V><L><Q><R><A><L><A><A><P><L><V><W><I><L><L><A><L><L><D><G><K><C><F><V><C><A><F><S><S><S><V><D><P><E><K><F><L><D><F><A><N><M><T><P><S><Q><V><Q><L><F><L><A><K><V><P><C><K><E><D><E><L><V><R><D><S><P><A><R><K><A><V><S><R><Y><L><R><C><L><S><Q><A><I><G><W><S><V><T><L><L><L><I><I><A><A><F><L><A><R><C><L><R><P><C><F><D><Q><T><V><F><L><Q><R><R><Y><W><S><N><Y><V><D><L><E><Q><K><L><F><D><E><T><C><C><E><H><A><R><D><F><A><H><R><C><V><L><H><F><F><A><S><M><R><S><E><L><Q><A><R><G><L><R><R><G><N><A><G><R><R><L><E><L><P><A><V><P><E><P><P><E><G><L><D><S><G><S><G><K><A><H><L><R><A><I><S><S><R><E><Q><V><D><R><L><L><S><T><W><Y><S><S><K><P><P><L><D><L><A><A><S><P><G><L><C><G><G><G><L><S><H><R><A><P><T><L><A><L><G><T><R><L><S><Q><H><T><D><V>
Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances.<BOP>
Q86XJ0
Q9HAW8
UD110_HUMAN
UDP-glucuronosyltransferase 1-J
Homo
<M><A><R><A><G><W><T><S><P><V><P><L><C><V><C><L><L><L><T><C><G><F><A><E><A><G><K><L><L><V><V><P><M><D><G><S><H><W><F><T><M><Q><S><V><V><E><K><L><I><L><R><G><H><E><V><V><V><V><M><P><E><V><S><W><Q><L><E><R><S><L><N><C><T><V><K><T><Y><S><T><S><Y><T><L><E><D><Q><N><R><E><F><M><V><F><A><H><A><Q><W><K><A><Q><A><Q><S><I><F><S><L><L><M><S><S><S><S><G><F><L><D><L><F><F><S><H><C><R><S><L><F><N><D><R><K><L><V><E><Y><L><K><E><S><S><F><D><A><V><F><L><D><P><F><D><T><C><G><L><I><V><A><K><Y><F><S><L><P><S><V><V><F><T><R><G><I><F><C><H><H><L><E><E><G><A><Q><C><P><A><P><L><S><Y><V><P><N><D><L><L><G><F><S><D><A><M><T><F><K><E><R><V><W><N><H><I><V><H><L><E><D><H><L><F><C><Q><Y><L><F><R><N><A><L><E><I><A><S><E><I><L><Q><T><P><V><T><A><Y><D><L><Y><S><H><T><S><I><W><L><L><R><T><D><F><V><L><D><Y><P><K><P><V><M><P><N><M><I><F><I><G><G><I><N><C><H><Q><G><K><P><L><P><M><E><F><E><A><Y><I><N><A><S><G><E><H><G><I><V><V><F><S><L><G><S><M><V><S><E><I><P><E><K><K><A><M><A><I><A><D><A><L><G><K><I><P><Q><T><V><L><W><R><Y><T><G><T><R><P><S><N><L><A><N><N><T><I><L><V><K><W><L><P><Q><N><D><L><L><G><H><P><M><T><R><A><F><I><T><H><A><G><S><H><G><V><Y><E><S><I><C><N><G><V><P><M><V><M><M><P><L><F><G><D><Q><M><D><N><A><K><R><M><E><T><K><G><A><G><V><T><L><N><V><L><E><M><T><S><E><D><L><E><N><A><L><K><A><V><I><N><D><K><S><Y><K><E><N><I><M><R><L><S><S><L><H><K><D><R><P><V><E><P><L><D><L><A><V><F><W><V><E><F><V><M><R><H><K><G><A><P><H><L><R><P><A><A><H><D><L><T><W><Y><Q><Y><H><S><L><D><V><I><G><F><L><L><A><V><V><L><T><V><A><F><I><T><F><K><C><C><A><Y><G><Y><R><K><C><L><G><K><K><G><R><V><K><K><A><H><K><S><K><T><H>
Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.<BOP>
Q9HAW8
P51649
SSDH_HUMAN
NAD(+)-dependent succinic semialdehyde dehydrogenase
Homo
<M><A><T><C><I><W><L><R><S><C><G><A><R><R><L><G><S><T><F><P><G><C><R><L><R><P><R><A><G><G><L><V><P><A><S><G><P><A><P><G><P><A><Q><L><R><C><Y><A><G><R><L><A><G><L><S><A><A><L><L><R><T><D><S><F><V><G><G><R><W><L><P><A><A><A><T><F><P><V><Q><D><P><A><S><G><A><A><L><G><M><V><A><D><C><G><V><R><E><A><R><A><A><V><R><A><A><Y><E><A><F><C><R><W><R><E><V><S><A><K><E><R><S><S><L><L><R><K><W><Y><N><L><M><I><Q><N><K><D><D><L><A><R><I><I><T><A><E><S><G><K><P><L><K><E><A><H><G><E><I><L><Y><S><A><F><F><L><E><W><F><S><E><E><A><R><R><V><Y><G><D><I><I><H><T><P><A><K><D><R><R><A><L><V><L><K><Q><P><I><G><V><A><A><V><I><T><P><W><N><F><P><S><A><M><I><T><R><K><V><G><A><A><L><A><A><G><C><T><V><V><V><K><P><A><E><D><T><P><F><S><A><L><A><L><A><E><L><A><S><Q><A><G><I><P><S><G><V><Y><N><V><I><P><C><S><R><K><N><A><K><E><V><G><E><A><I><C><T><D><P><L><V><S><K><I><S><F><T><G><S><T><T><T><G><K><I><L><L><H><H><A><A><N><S><V><K><R><V><S><M><E><L><G><G><L><A><P><F><I><V><F><D><S><A><N><V><D><Q><A><V><A><G><A><M><A><S><K><F><R><N><T><G><Q><T><C><V><C><S><N><Q><F><L><V><Q><R><G><I><H><D><A><F><V><K><A><F><A><E><A><M><K><K><N><L><R><V><G><N><G><F><E><E><G><T><T><Q><G><P><L><I><N><E><K><A><V><E><K><V><E><K><Q><V><N><D><A><V><S><K><G><A><T><V><V><T><G><G><K><R><H><Q><L><G><K><N><F><F><E><P><T><L><L><C><N><V><T><Q><D><M><L><C><T><H><E><E><T><F><G><P><L><A><P><V><I><K><F><D><T><E><E><E><A><I><A><I><A><N><A><A><D><V><G><L><A><G><Y><F><Y><S><Q><D><P><A><Q><I><W><R><V><A><E><Q><L><E><V><G><M><V><G><V><N><E><G><L><I><S><S><V><E><C><P><F><G><G><V><K><Q><S><G><L><G><R><E><G><S><K><Y><G><I><D><E><Y><L><E><L><K><Y><V><C><Y><G><G><L>
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).<BOP>
P51649
P14672
GLUT4_HUMAN
Glucose transporter type 4, insulin-responsive
Homo
<M><P><S><G><F><Q><Q><I><G><S><E><D><G><E><P><P><Q><Q><R><V><T><G><T><L><V><L><A><V><F><S><A><V><L><G><S><L><Q><F><G><Y><N><I><G><V><I><N><A><P><Q><K><V><I><E><Q><S><Y><N><E><T><W><L><G><R><Q><G><P><E><G><P><S><S><I><P><P><G><T><L><T><T><L><W><A><L><S><V><A><I><F><S><V><G><G><M><I><S><S><F><L><I><G><I><I><S><Q><W><L><G><R><K><R><A><M><L><V><N><N><V><L><A><V><L><G><G><S><L><M><G><L><A><N><A><A><A><S><Y><E><M><L><I><L><G><R><F><L><I><G><A><Y><S><G><L><T><S><G><L><V><P><M><Y><V><G><E><I><A><P><T><H><L><R><G><A><L><G><T><L><N><Q><L><A><I><V><I><G><I><L><I><A><Q><V><L><G><L><E><S><L><L><G><T><A><S><L><W><P><L><L><L><G><L><T><V><L><P><A><L><L><Q><L><V><L><L><P><F><C><P><E><S><P><R><Y><L><Y><I><I><Q><N><L><E><G><P><A><R><K><S><L><K><R><L><T><G><W><A><D><V><S><G><V><L><A><E><L><K><D><E><K><R><K><L><E><R><E><R><P><L><S><L><L><Q><L><L><G><S><R><T><H><R><Q><P><L><I><I><A><V><V><L><Q><L><S><Q><Q><L><S><G><I><N><A><V><F><Y><Y><S><T><S><I><F><E><T><A><G><V><G><Q><P><A><Y><A><T><I><G><A><G><V><V><N><T><V><F><T><L><V><S><V><L><L><V><E><R><A><G><R><R><T><L><H><L><L><G><L><A><G><M><C><G><C><A><I><L><M><T><V><A><L><L><L><L><E><R><V><P><A><M><S><Y><V><S><I><V><A><I><F><G><F><V><A><F><F><E><I><G><P><G><P><I><P><W><F><I><V><A><E><L><F><S><Q><G><P><R><P><A><A><M><A><V><A><G><F><S><N><W><T><S><N><F><I><I><G><M><G><F><Q><Y><V><A><E><A><M><G><P><Y><V><F><L><L><F><A><V><L><L><L><G><F><F><I><F><T><F><L><R><V><P><E><T><R><G><R><T><F><D><Q><I><S><A><A><F><H><R><T><P><S><L><L><E><Q><E><V><K><P><S><T><E><L><E><Y><L><G><P><D><E><N><D>
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.<BOP>
P14672
Q8N8Q1
C56D1_HUMAN
Cytochrome b561 domain-containing protein 1
Homo
<M><Q><P><L><E><V><G><L><V><P><A><P><A><G><E><P><R><L><T><R><W><L><R><R><G><S><G><I><L><A><H><L><V><A><L><G><F><T><I><F><L><T><A><L><S><R><P><G><T><S><L><F><S><W><H><P><V><F><M><A><L><A><F><C><L><C><M><A><E><A><I><L><L><F><S><P><E><H><S><L><F><F><F><C><S><R><K><A><R><I><R><L><H><W><A><G><Q><T><L><A><I><L><C><A><A><L><G><L><G><F><I><I><S><S><R><T><R><S><E><L><P><H><L><V><S><W><H><S><W><V><G><A><L><T><L><L><A><T><A><V><Q><A><L><C><G><L><C><L><L><C><P><R><A><A><R><V><S><R><V><A><R><L><K><L><Y><H><L><T><C><G><L><V><V><Y><L><M><A><T><V><T><V><L><L><G><M><Y><S><V><W><F><Q><A><Q><I><K><G><A><A><W><Y><L><C><L><A><L><P><V><Y><P><A><L><V><I><M><H><Q><I><S><R><S><Y><L><P><R><K><K><M><E><M>
Probable transmembrane reductase that may use ascorbate as an electron donor and transfer electrons across membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in another cellular compartment.<BOP>
Q8N8Q1
Q9BT23
LIMD2_HUMAN
LIM domain-containing protein 2
Homo
<M><F><Q><A><A><G><A><A><Q><A><T><P><S><H><D><A><K><G><G><G><S><S><T><V><Q><R><S><K><S><F><S><L><R><A><Q><V><K><E><T><C><A><A><C><Q><K><T><V><Y><P><M><E><R><L><V><A><D><K><L><I><F><H><N><S><C><F><C><C><K><H><C><H><T><K><L><S><L><G><S><Y><A><A><L><H><G><E><F><Y><C><K><P><H><F><Q><Q><L><F><K><S><K><G><N><Y><D><E><G><F><G><R><K><Q><H><K><E><L><W><A><H><K><E><V><D><P><G><T><K><T><A>
Acts as an activator of the protein-kinase ILK, thereby regulating cell motility .<BOP>
Q9BT23
Q5TID7
CC181_HUMAN
Coiled-coil domain-containing protein 181
Homo
<M><N><E><N><K><D><T><D><S><K><K><S><E><E><Y><E><D><D><F><E><K><D><L><E><W><L><I><N><E><N><E><K><S><D><A><S><I><I><E><M><A><C><E><K><E><E><N><I><N><Q><D><L><K><E><N><E><T><V><M><E><H><T><K><R><H><S><D><P><D><K><S><L><Q><D><E><V><S><P><R><R><N><D><I><I><S><V><P><G><I><Q><P><L><D><P><I><S><D><S><D><S><E><N><S><F><Q><E><S><K><L><E><S><Q><K><D><L><E><E><E><E><D><E><E><V><R><R><Y><I><M><E><K><I><V><Q><A><N><K><L><L><Q><N><Q><E><P><V><N><D><K><R><E><R><K><L><K><F><K><D><Q><L><V><D><L><E><V><P><P><L><E><D><T><T><T><F><K><N><Y><F><E><N><E><R><N><M><F><G><K><L><S><Q><L><C><I><S><N><D><F><G><Q><E><D><V><L><L><S><L><T><N><G><S><C><E><E><N><K><D><R><T><I><L><V><E><R><D><G><K><F><E><L><L><N><L><Q><D><I><A><S><Q><G><F><L><P><P><I><N><N><A><N><S><T><E><N><D><P><Q><Q><L><L><P><R><S><S><N><S><S><V><S><G><T><K><K><E><D><S><T><A><K><I><H><A><V><T><H><S><S><T><G><E><P><L><A><Y><I><A><Q><P><P><L><N><R><K><T><C><P><S><S><A><V><N><S><D><R><S><K><G><N><G><K><S><N><H><R><T><Q><S><A><H><I><S><P><V><T><S><T><Y><C><L><S><P><R><Q><K><E><L><Q><K><Q><L><E><E><K><R><E><K><L><K><R><E><E><E><R><R><K><I><E><E><E><K><E><K><K><R><E><N><D><I><V><F><K><A><W><L><Q><K><K><R><E><Q><V><L><E><M><R><R><I><Q><R><A><K><E><I><E><D><M><N><S><R><Q><E><N><R><D><P><Q><Q><A><F><R><L><W><L><K><K><K><H><E><E><Q><M><K><E><R><Q><T><E><E><L><R><K><Q><E><E><C><L><F><F><L><K><G><T><E><G><R><E><R><A><F><K><Q><W><L><R><R><K><R><M><E><K><M><A><E><Q><Q><A><V><R><E><R><T><R><Q><L><R><L><E><A><K><R><S><K><Q><L><Q><H><H><L><Y><M><S><E><A><K><P><F><R><F><T><D><H><Y><N>
Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.<BOP>
Q5TID7
Q5T0N5
FBP1L_HUMAN
Transducer of Cdc42-dependent actin assembly protein 1
Homo
<M><S><W><G><T><E><L><W><D><Q><F><D><S><L><D><K><H><T><Q><W><G><I><D><F><L><E><R><Y><A><K><F><V><K><E><R><I><E><I><E><Q><N><Y><A><K><Q><L><R><N><L><V><K><K><Y><C><P><K><R><S><S><K><D><E><E><P><R><F><T><S><C><V><A><F><F><N><I><L><N><E><L><N><D><Y><A><G><Q><R><E><V><V><A><E><E><M><A><H><R><V><Y><G><E><L><M><R><Y><A><H><D><L><K><T><E><R><K><M><H><L><Q><E><G><R><K><A><Q><Q><Y><L><D><M><C><W><K><Q><M><D><N><S><K><K><K><F><E><R><E><C><R><E><A><E><K><A><Q><Q><S><Y><E><R><L><D><N><D><T><N><A><T><K><A><D><V><E><K><A><K><Q><Q><L><N><L><R><T><H><M><A><D><E><N><K><N><E><Y><A><A><Q><L><Q><N><F><N><G><E><Q><H><K><H><F><Y><V><V><I><P><Q><I><Y><K><Q><L><Q><E><M><D><E><R><R><T><I><K><L><S><E><C><Y><R><G><F><A><D><S><E><R><K><V><I><P><I><I><S><K><C><L><E><G><M><I><L><A><A><K><S><V><D><E><R><R><D><S><Q><M><V><V><D><S><F><K><S><G><F><E><P><P><G><D><F><P><F><E><D><Y><S><Q><H><I><Y><R><T><I><S><D><G><T><I><S><A><S><K><Q><E><S><G><K><M><D><A><K><T><T><V><G><K><A><K><G><K><L><W><L><F><G><K><K><P><K><P><Q><S><P><P><L><T><P><T><S><L><F><T><S><S><T><P><N><G><S><Q><F><L><T><F><S><I><E><P><V><H><Y><C><M><N><E><I><K><T><G><K><P><R><I><P><S><F><R><S><L><K><R><G><W><S><V><K><M><G><P><A><L><E><D><F><S><H><L><P><P><E><Q><R><R><K><K><L><Q><Q><R><I><D><E><L><N><R><E><L><Q><K><E><S><D><Q><K><D><A><L><N><K><M><K><D><V><Y><E><K><N><P><Q><M><G><D><P><G><S><L><Q><P><K><L><A><E><T><M><N><N><I><D><R><L><R><M><E><I><H><K><N><E><A><W><L><S><E><V><E><G><K><T><G><G><R><G><D><R><R><H><S><S><D><I><N><H><L><V><T><Q><G><R><E><S><P><E><G><S><Y><T><D><D><A><N><Q><E><V><R><G><P><P><Q><Q><H><G><H><H><N><E><F><D><D><E><F><E><D><D><D><P><L><P><A><I><G><H><C><K><A><I><Y><P><F><D><G><H><N><E><G><T><L><A><M><K><E><G><E><V><L><Y><I><I><E><E><D><K><G><D><G><W><T><R><A><R><R><Q><N><G><E><E><G><Y><V><P><T><S><Y><I><D><V><T><L><E><K><N><S><K><G><S>
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.<BOP>
Q5T0N5
P07108
ACBP_HUMAN
Endozepine
Homo
<M><S><Q><A><E><F><E><K><A><A><E><E><V><R><H><L><K><T><K><P><S><D><E><E><M><L><F><I><Y><G><H><Y><K><Q><A><T><V><G><D><I><N><T><E><R><P><G><M><L><D><F><T><G><K><A><K><W><D><A><W><N><E><L><K><G><T><S><K><E><D><A><M><K><A><Y><I><N><K><V><E><E><L><K><K><K><Y><G><I>
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.<BOP>
P07108
Q6ZRP7
QSOX2_HUMAN
Quiescin Q6-like protein 1
Homo
<M><A><A><A><G><A><A><V><A><R><S><P><G><I><G><A><G><P><A><L><R><A><R><R><S><P><P><P><R><A><A><R><L><P><R><L><L><V><L><L><A><A><A><A><V><G><P><G><A><G><G><A><A><R><L><Y><R><A><G><E><D><A><V><W><V><L><D><S><G><S><V><R><G><A><T><A><N><S><S><A><A><W><L><V><Q><F><Y><S><S><W><C><G><H><C><I><G><Y><A><P><T><W><R><A><L><A><G><D><V><R><D><W><A><S><A><I><R><V><A><A><L><D><C><M><E><E><K><N><Q><A><V><C><H><D><Y><D><I><H><F><Y><P><T><F><R><Y><F><K><A><F><T><K><E><F><T><T><G><E><N><F><K><G><P><D><R><E><L><R><T><V><R><Q><T><M><I><D><F><L><Q><N><H><T><E><G><S><R><P><P><A><C><P><R><L><D><P><I><Q><P><S><D><V><L><S><L><L><D><N><R><G><S><H><Y><V><A><I><V><F><E><S><N><S><S><Y><L><G><R><E><V><I><L><D><L><I><P><Y><E><S><I><V><V><T><R><A><L><D><G><D><K><A><F><L><E><K><L><G><V><S><S><V><P><S><C><Y><L><I><Y><P><N><G><S><H><G><L><I><N><V><V><K><P><L><R><A><F><F><S><S><Y><L><K><S><L><P><D><V><R><K><K><S><L><P><L><P><E><K><P><H><K><E><E><N><S><E><I><V><V><W><R><E><F><D><K><S><K><L><Y><T><V><D><L><E><S><G><L><H><Y><L><L><R><V><E><L><A><A><H><K><S><L><A><G><A><E><L><K><T><L><K><D><F><V><T><V><L><A><K><L><F><P><G><R><P><P><V><K><K><L><L><E><M><L><Q><E><W><L><A><S><L><P><L><D><R><I><P><Y><N><A><V><L><D><L><V><N><N><K><M><R><I><S><G><I><F><L><T><N><H><I><K><W><V><G><C><Q><G><S><R><S><E><L><R><G><Y><P><C><S><L><W><K><L><F><H><T><L><T><V><E><A><S><T><H><P><D><A><L><V><G><T><G><F><E><D><D><P><Q><A><V><L><Q><T><M><R><R><Y><V><H><T><F><F><G><C><K><E><C><G><E><H><F><E><E><M><A><K><E><S><M><D><S><V><K><T><P><D><Q><A><I><L><W><L><W><K><K><H><N><M><V><N><G><R><L><A><G><H><L><S><E><D><P><R><F><P><K><L><Q><W><P><T><P><D><L><C><P><A><C><H><E><E><I><K><G><L><A><S><W><D><E><G><H><V><L><T><F><L><K><Q><H><Y><G><R><D><N><L><L><D><T><Y><S><A><D><Q><G><D><S><S><E><G><G><T><L><A><R><G><E><E><E><E><K><R><L><T><P><P><E><V><S><H><G><D><R><D><T><Q><S><V><R><P><P><G><A><L><G><P><R><P><A><L><P><E><S><L><H><H><S><L><D><G><K><L><Q><S><L><D><G><P><G><A><H><K><E><V><G><G><A><A><P><F><L><G><V><D><F><S><S><L><D><M><S><L><C><V><V><L><Y><V><A><S><S><L><F><L><M><V><M><Y><F><F><F><R><V><R><S><R><R><W><K><V><K><H><H><H><P><A><V>
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.<BOP>
Q6ZRP7
Q9BYQ9
KRA48_HUMAN
Ultrahigh sulfur keratin-associated protein 4.8
Homo
<M><V><N><S><C><C><G><S><V><C><S><D><Q><G><C><G><Q><D><L><C><Q><E><T><C><C><C><P><S><C><C><Q><T><T><C><C><R><T><T><C><Y><R><P><S><Y><S><V><S><C><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><C><V><S><S><C><C><K><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><H><P><S><C><C><I><S><S><C><C><R><P><S><C><C><V><S><S><C><C><K><P><Q><C><C><Q><S><V><C><C><Q><P><N><C><C><R><P><S><C><S><I><S><S><C><C><R><P><S><C><C><E><S><S><C><C><R><P><C><C><C><L><R><P><V><C><G><R><V><S><C><H><T><T><C><Y><R><P><A><C><V><I><S><T><C><P><R><P><V><C><C><A><S><S><C><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q9BYQ9
P50402
EMD_HUMAN
Emerin
Homo
<M><D><N><Y><A><D><L><S><D><T><E><L><T><T><L><L><R><R><Y><N><I><P><H><G><P><V><V><G><S><T><R><R><L><Y><E><K><K><I><F><E><Y><E><T><Q><R><R><R><L><S><P><P><S><S><S><A><A><S><S><Y><S><F><S><D><L><N><S><T><R><G><D><A><D><M><Y><D><L><P><K><K><E><D><A><L><L><Y><Q><S><K><G><Y><N><D><D><Y><Y><E><E><S><Y><F><T><T><R><T><Y><G><E><P><E><S><A><G><P><S><R><A><V><R><Q><S><V><T><S><F><P><D><A><D><A><F><H><H><Q><V><H><D><D><D><L><L><S><S><S><E><E><E><C><K><D><R><E><R><P><M><Y><G><R><D><S><A><Y><Q><S><I><T><H><Y><R><P><V><S><A><S><R><S><S><L><D><L><S><Y><Y><P><T><S><S><S><T><S><F><M><S><S><S><S><S><S><S><S><W><L><T><R><R><A><I><R><P><E><N><R><A><P><G><A><G><L><G><Q><D><R><Q><V><P><L><W><G><Q><L><L><L><F><L><V><F><V><I><V><L><F><F><I><Y><H><F><M><Q><A><E><E><G><N><P><F>
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells . EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.<BOP>
P50402
P52294
IMA5_HUMAN
Importin subunit alpha-5, N-terminally processed
Homo
<M><T><T><P><G><K><E><N><F><R><L><K><S><Y><K><N><K><S><L><N><P><D><E><M><R><R><R><R><E><E><E><G><L><Q><L><R><K><Q><K><R><E><E><Q><L><F><K><R><R><N><V><A><T><A><E><E><E><T><E><E><E><V><M><S><D><G><G><F><H><E><A><Q><I><S><N><M><E><M><A><P><G><G><V><I><T><S><D><M><I><E><M><I><F><S><K><S><P><E><Q><Q><L><S><A><T><Q><K><F><R><K><L><L><S><K><E><P><N><P><P><I><D><E><V><I><S><T><P><G><V><V><A><R><F><V><E><F><L><K><R><K><E><N><C><T><L><Q><F><E><S><A><W><V><L><T><N><I><A><S><G><N><S><L><Q><T><R><I><V><I><Q><A><G><A><V><P><I><F><I><E><L><L><S><S><E><F><E><D><V><Q><E><Q><A><V><W><A><L><G><N><I><A><G><D><S><T><M><C><R><D><Y><V><L><D><C><N><I><L><P><P><L><L><Q><L><F><S><K><Q><N><R><L><T><M><T><R><N><A><V><W><A><L><S><N><L><C><R><G><K><S><P><P><P><E><F><A><K><V><S><P><C><L><N><V><L><S><W><L><L><F><V><S><D><T><D><V><L><A><D><A><C><W><A><L><S><Y><L><S><D><G><P><N><D><K><I><Q><A><V><I><D><A><G><V><C><R><R><L><V><E><L><L><M><H><N><D><Y><K><V><V><S><P><A><L><R><A><V><G><N><I><V><T><G><D><D><I><Q><T><Q><V><I><L><N><C><S><A><L><Q><S><L><L><H><L><L><S><S><P><K><E><S><I><K><K><E><A><C><W><T><I><S><N><I><T><A><G><N><R><A><Q><I><Q><T><V><I><D><A><N><I><F><P><A><L><I><S><I><L><Q><T><A><E><F><R><T><R><K><E><A><A><W><A><I><T><N><A><T><S><G><G><S><A><E><Q><I><K><Y><L><V><E><L><G><C><I><K><P><L><C><D><L><L><T><V><M><D><S><K><I><V><Q><V><A><L><N><G><L><E><N><I><L><R><L><G><E><Q><E><A><K><R><N><G><T><G><I><N><P><Y><C><A><L><I><E><E><A><Y><G><L><D><K><I><E><F><L><Q><S><H><E><N><Q><E><I><Y><Q><K><A><F><D><L><I><E><H><Y><F><G><T><E><D><E><D><S><S><I><A><P><Q><V><D><L><N><Q><Q><Q><Y><I><F><Q><Q><C><E><A><P><M><E><G><F><Q><L>
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.<BOP>
P52294
P18510
IL1RA_HUMAN
IL1 inhibitor
Homo
<M><E><I><C><R><G><L><R><S><H><L><I><T><L><L><L><F><L><F><H><S><E><T><I><C><R><P><S><G><R><K><S><S><K><M><Q><A><F><R><I><W><D><V><N><Q><K><T><F><Y><L><R><N><N><Q><L><V><A><G><Y><L><Q><G><P><N><V><N><L><E><E><K><I><D><V><V><P><I><E><P><H><A><L><F><L><G><I><H><G><G><K><M><C><L><S><C><V><K><S><G><D><E><T><R><L><Q><L><E><A><V><N><I><T><D><L><S><E><N><R><K><Q><D><K><R><F><A><F><I><R><S><D><S><G><P><T><T><S><F><E><S><A><A><C><P><G><W><F><L><C><T><A><M><E><A><D><Q><P><V><S><L><T><N><M><P><D><E><G><V><M><V><T><K><F><Y><F><Q><E><D><E>
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.<BOP>
P18510
Q15036
SNX17_HUMAN
Sorting nexin-17
Homo
<M><H><F><S><I><P><E><T><E><S><R><S><G><D><S><G><G><S><A><Y><V><A><Y><N><I><H><V><N><G><V><L><H><C><R><V><R><Y><S><Q><L><L><G><L><H><E><Q><L><R><K><E><Y><G><A><N><V><L><P><A><F><P><P><K><K><L><F><S><L><T><P><A><E><V><E><Q><R><R><E><Q><L><E><K><Y><M><Q><A><V><R><Q><D><P><L><L><G><S><S><E><T><F><N><S><F><L><R><R><A><Q><Q><E><T><Q><Q><V><P><T><E><E><V><S><L><E><V><L><L><S><N><G><Q><K><V><L><V><N><V><L><T><S><D><Q><T><E><D><V><L><E><A><V><A><A><K><L><D><L><P><D><D><L><I><G><Y><F><S><L><F><L><V><R><E><K><E><D><G><A><F><S><F><V><R><K><L><Q><E><F><E><L><P><Y><V><S><V><T><S><L><R><S><Q><E><Y><K><I><V><L><R><K><S><Y><W><D><S><A><Y><D><D><D><V><M><E><N><R><V><G><L><N><L><L><Y><A><Q><T><V><S><D><I><E><R><G><W><I><L><V><T><K><E><Q><H><R><Q><L><K><S><L><Q><E><K><V><S><K><K><E><F><L><R><L><A><Q><T><L><R><H><Y><G><Y><L><R><F><D><A><C><V><A><D><F><P><E><K><D><C><P><V><V><V><S><A><G><N><S><E><L><S><L><Q><L><R><L><P><G><Q><Q><L><R><E><G><S><F><R><V><T><R><M><R><C><W><R><V><T><S><S><V><P><L><P><S><G><S><T><S><S><P><G><R><G><R><G><E><V><R><L><E><L><A><F><E><Y><L><M><S><K><D><R><L><Q><W><V><T><I><T><S><P><Q><A><I><M><M><S><I><C><L><Q><S><M><V><D><E><L><M><V><K><K><S><G><G><S><I><R><K><M><L><R><R><R><V><G><G><T><L><R><R><S><D><S><Q><Q><A><V><K><S><P><P><L><L><E><S><P><D><A><T><R><E><S><M><V><K><L><S><S><K><L><S><A><V><S><L><R><G><I><G><S><P><S><T><D><A><S><A><S><D><V><H><G><N><F><A><F><E><G><I><G><D><E><D><L>
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels . Binds to NPxY sequences in the cytoplasmic tails of target cargos . Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits . Also required for maintenance of normal cell surface levels of APP and LRP1 . Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) .<BOP>
Q15036
P62807
H2B1C_HUMAN
Histone H2B.l
Homo
<M><P><E><P><A><K><S><A><P><A><P><K><K><G><S><K><K><A><V><T><K><A><Q><K><K><D><G><K><K><R><K><R><S><R><K><E><S><Y><S><V><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><G><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><E><I><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><S><K>
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<BOP>
P62807
P22234
PUR6_HUMAN
SAICAR synthetase
Homo
<M><A><T><A><E><V><L><N><I><G><K><K><L><Y><E><G><K><T><K><E><V><Y><E><L><L><D><S><P><G><K><V><L><L><Q><S><K><D><Q><I><T><A><G><N><A><A><R><K><N><H><L><E><G><K><A><A><I><S><N><K><I><T><S><C><I><F><Q><L><L><Q><E><A><G><I><K><T><A><F><T><R><K><C><G><E><T><A><F><I><A><P><Q><C><E><M><I><P><I><E><W><V><C><R><R><I><A><T><G><S><F><L><K><R><N><P><G><V><K><E><G><Y><K><F><Y><P><P><K><V><E><L><F><F><K><D><D><A><N><N><D><P><Q><W><S><E><E><Q><L><I><A><A><K><F><C><F><A><G><L><L><I><G><Q><T><E><V><D><I><M><S><H><A><T><Q><A><I><F><E><I><L><E><K><S><W><L><P><Q><N><C><T><L><V><D><M><K><I><E><F><G><V><D><V><T><T><K><E><I><V><L><A><D><V><I><D><N><D><S><W><R><L><W><P><S><G><D><R><S><Q><Q><K><D><K><Q><S><Y><R><D><L><K><E><V><T><P><E><G><L><Q><M><V><K><K><N><F><E><W><V><A><E><R><V><E><L><L><L><K><S><E><S><Q><C><R><V><V><V><L><M><G><S><T><S><D><L><G><H><C><E><K><I><K><K><A><C><G><N><F><G><I><P><C><E><L><R><V><T><S><A><H><K><G><P><D><E><T><L><R><I><K><A><E><Y><E><G><D><G><I><P><T><V><F><V><A><V><A><G><R><S><N><G><L><G><P><V><M><S><G><N><T><A><Y><P><V><I><S><C><P><P><L><T><P><D><W><G><V><Q><D><V><W><S><S><L><R><L><P><S><G><L><G><C><S><T><V><L><S><P><E><G><S><A><Q><F><A><A><Q><I><F><G><L><S><N><H><L><V><W><S><K><L><R><A><S><I><L><N><T><W><I><S><L><K><Q><A><D><K><K><I><R><E><C><N><L>
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.<BOP>
P22234
A0A0B4J274
TVA20_HUMAN
T cell receptor alpha variable 20
Homo
<M><E><K><M><L><E><C><A><F><I><V><L><W><L><Q><L><G><W><L><S><G><E><D><Q><V><T><Q><S><P><E><A><L><R><L><Q><E><G><E><S><S><S><L><N><C><S><Y><T><V><S><G><L><R><G><L><F><W><Y><R><Q><D><P><G><K><G><P><E><F><L><F><T><L><Y><S><A><G><E><E><K><E><K><E><R><L><K><A><T><L><T><K><K><E><S><F><L><H><I><T><A><P><K><P><E><D><S><A><T><Y><L><C><A><V><Q>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0B4J274
A0M8Q6
IGLC7_HUMAN
Ig lambda-7 chain C region
Homo
<G><Q><P><K><A><A><P><S><V><T><L><F><P><P><S><S><E><E><L><Q><A><N><K><A><T><L><V><C><L><V><S><D><F><N><P><G><A><V><T><V><A><W><K><A><D><G><S><P><V><K><V><G><V><E><T><T><K><P><S><K><Q><S><N><N><K><Y><A><A><S><S><Y><L><S><L><T><P><E><Q><W><K><S><H><R><S><Y><S><C><R><V><T><H><E><G><S><T><V><E><K><T><V><A><P><A><E><C><S>
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0M8Q6
Q8NDC4
MORN4_HUMAN
Retinophilin
Homo
<M><T><L><T><K><G><S><F><T><Y><S><S><G><E><E><Y><R><G><E><W><K><E><G><R><R><H><G><F><G><Q><L><M><F><A><D><G><G><T><Y><L><G><H><F><E><N><G><L><F><N><G><F><G><V><L><T><F><S><D><G><S><R><Y><E><G><E><F><A><Q><G><K><F><N><G><V><G><V><F><I><R><Y><D><N><M><T><F><E><G><E><F><K><N><G><R><V><D><G><F><G><L><L><T><F><P><D><G><S><H><G><I><P><R><N><E><G><L><F><E><N><N><K><L><L><R><R><E><K><C><S><A><I><V><Q><R><A><Q><S><A><S><K><S><A><R><N><L><T><A>
Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.<BOP>
Q8NDC4
Q96IZ2
ADTRP_HUMAN
Fatty acid esters of hydroxy fatty acids hydrolase ADTRP
Homo
<M><T><K><T><S><T><C><I><Y><H><F><L><V><L><S><W><Y><T><F><L><N><Y><Y><I><S><Q><E><G><K><D><E><V><K><P><K><I><L><A><N><G><A><R><W><K><Y><M><T><L><L><N><L><L><L><Q><T><I><F><Y><G><V><T><C><L><D><D><V><L><K><R><T><K><G><G><K><D><I><K><F><L><T><A><F><R><D><L><L><F><T><T><L><A><F><P><V><S><T><F><V><F><L><A><F><W><I><L><F><L><Y><N><R><D><L><I><Y><P><K><V><L><D><T><V><I><P><V><W><L><N><H><A><M><H><T><F><I><F><P><I><T><L><A><E><V><V><L><R><P><H><S><Y><P><S><K><K><T><G><L><T><L><L><A><A><A><S><I><A><Y><I><S><R><I><L><W><L><Y><F><E><T><G><T><W><V><Y><P><V><F><A><K><L><S><L><L><G><L><A><A><F><F><S><L><S><Y><V><F><I><A><S><I><Y><L><L><G><E><K><L><N><H><W><K><W><G><D><M><R><Q><P><R><K><K><R><K>
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids . Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids . Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) .<BOP>
Q96IZ2
Q9BV36
MELPH_HUMAN
Synaptotagmin-like protein 2a
Homo
<M><G><K><K><L><D><L><S><K><L><T><D><E><E><A><Q><H><V><L><E><V><V><Q><R><D><F><D><L><R><R><K><E><E><E><R><L><E><A><L><K><G><K><I><K><K><E><S><S><K><R><E><L><L><S><D><T><A><H><L><N><E><T><H><C><A><R><C><L><Q><P><Y><Q><L><L><V><N><S><K><R><Q><C><L><E><C><G><L><F><T><C><K><S><C><G><R><V><H><P><E><E><Q><G><W><I><C><D><P><C><H><L><A><R><V><V><K><I><G><S><L><E><W><Y><Y><E><H><V><K><A><R><F><K><R><F><G><S><A><K><V><I><R><S><L><H><G><R><L><Q><G><G><A><G><P><E><L><I><S><E><E><R><S><G><D><S><D><Q><T><D><E><D><G><E><P><G><S><E><A><Q><A><Q><A><Q><P><F><G><S><K><K><K><R><L><L><S><V><H><D><F><D><F><E><G><D><S><D><D><S><T><Q><P><Q><G><H><S><L><H><L><S><S><V><P><E><A><R><D><S><P><Q><S><L><T><D><E><S><C><S><E><K><A><A><P><H><K><A><E><G><L><E><E><A><D><T><G><A><S><G><C><H><S><H><P><E><E><Q><P><T><S><I><S><P><S><R><H><G><A><L><A><E><L><C><P><P><G><G><S><H><R><M><A><L><G><T><A><A><A><L><G><S><N><V><I><R><N><E><Q><L><P><L><Q><Y><L><A><D><V><D><T><S><D><E><E><S><I><R><A><H><V><M><A><S><H><H><S><K><R><R><G><R><A><S><S><E><S><Q><I><F><E><L><N><K><H><I><S><A><V><E><C><L><L><T><Y><L><E><N><T><V><V><P><P><L><A><K><G><L><G><A><G><V><R><T><E><A><D><V><E><E><E><A><L><R><R><K><L><E><E><L><T><S><N><V><S><D><Q><E><T><S><S><E><E><E><E><A><K><D><E><K><A><E><P><N><R><D><K><S><V><G><P><L><P><Q><A><D><P><E><V><G><T><A><A><H><Q><T><N><R><Q><E><K><S><P><Q><D><P><G><D><P><V><Q><Y><N><R><T><T><D><E><E><L><S><E><L><E><D><R><V><A><V><T><A><S><E><V><Q><Q><A><E><S><E><V><S><D><I><E><S><R><I><A><A><L><R><A><A><G><L><T><V><K><P><S><G><K><P><R><R><K><S><N><L><P><I><F><L><P><R><V><A><G><K><L><G><K><R><P><E><D><P><N><A><D><P><S><S><E><A><K><A><M><A><V><P><Y><L><L><R><R><K><F><S><N><S><L><K><S><Q><G><K><D><D><D><S><F><D><R><K><S><V><Y><R><G><S><L><T><Q><R><N><P><N><A><R><K><G><M><A><S><H><T><F><A><K><P><V><V><A><H><Q><S>
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.<BOP>
Q9BV36
Q96IR7
HPDL_HUMAN
Glyoxalase domain-containing protein 1
Homo
<M><A><A><P><A><L><R><L><C><H><I><A><F><H><V><P><A><G><Q><P><L><A><R><N><L><Q><R><L><F><G><F><Q><P><L><A><S><R><E><V><D><G><W><R><Q><L><A><L><R><S><G><D><A><V><F><L><V><N><E><G><A><G><S><G><E><P><L><Y><G><L><D><P><R><H><A><V><P><S><A><T><N><L><C><F><D><V><A><D><A><G><A><A><T><R><E><L><A><A><L><G><C><S><V><P><V><P><P><V><R><V><R><D><A><Q><G><A><A><T><Y><A><V><V><S><S><P><A><G><I><L><S><L><T><L><L><E><R><A><G><Y><R><G><P><F><L><P><G><F><R><P><V><S><S><A><P><G><P><G><W><V><S><R><V><D><H><L><T><L><A><C><T><P><G><S><S><P><T><L><L><R><W><F><H><D><C><L><G><F><C><H><L><P><L><S><P><G><E><D><P><E><L><G><L><E><M><T><A><G><F><G><L><G><G><L><R><L><T><A><L><Q><A><Q><P><G><S><I><V><P><T><L><V><L><A><E><S><L><P><G><A><T><T><R><Q><D><Q><V><E><Q><F><L><A><R><H><K><G><P><G><L><Q><H><V><G><L><Y><T><P><N><I><V><E><A><T><E><G><V><A><T><A><G><G><Q><F><L><A><P><P><G><A><Y><Y><Q><Q><P><G><K><E><R><Q><I><R><A><A><G><H><E><P><H><L><L><A><R><Q><G><I><L><L><D><G><D><K><G><K><F><L><L><Q><V><F><T><K><S><L><F><T><E><D><T><F><F><L><E><L><I><Q><R><Q><G><A><T><G><F><G><Q><G><N><I><R><A><L><W><Q><S><V><Q><E><Q><S><A><R><S><Q><E><A>
May have dioxygenase activity.<BOP>
Q96IR7
Q01151
CD83_HUMAN
Cell surface protein HB15
Homo
<M><S><R><G><L><Q><L><L><L><L><S><C><A><Y><S><L><A><P><A><T><P><E><V><K><V><A><C><S><E><D><V><D><L><P><C><T><A><P><W><D><P><Q><V><P><Y><T><V><S><W><V><K><L><L><E><G><G><E><E><R><M><E><T><P><Q><E><D><H><L><R><G><Q><H><Y><H><Q><K><G><Q><N><G><S><F><D><A><P><N><E><R><P><Y><S><L><K><I><R><N><T><T><S><C><N><S><G><T><Y><R><C><T><L><Q><D><P><D><G><Q><R><N><L><S><G><K><V><I><L><R><V><T><G><C><P><A><Q><R><K><E><E><T><F><K><K><Y><R><A><E><I><V><L><L><L><A><L><V><I><F><Y><L><T><L><I><I><F><T><C><K><F><A><R><L><Q><S><I><F><P><D><F><S><K><A><G><M><E><R><A><F><L><P><V><T><S><P><N><K><H><L><G><L><V><T><P><H><K><T><E><L><V>
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.<BOP>
Q01151
Q96JB5
CK5P3_HUMAN
Protein HSF-27
Homo
<M><E><D><H><Q><H><V><P><I><D><I><Q><T><S><K><L><L><D><W><L><V><D><R><R><H><C><S><L><K><W><Q><S><L><V><L><T><I><R><E><K><I><N><A><A><I><Q><D><M><P><E><S><E><E><I><A><Q><L><L><S><G><S><Y><I><H><Y><F><H><C><L><R><I><L><D><L><L><K><G><T><E><A><S><T><K><N><I><F><G><R><Y><S><S><Q><R><M><K><D><W><Q><E><I><I><A><L><Y><E><K><D><N><T><Y><L><V><E><L><S><S><L><L><V><R><N><V><N><Y><E><I><P><S><L><K><K><Q><I><A><K><C><Q><Q><L><Q><Q><E><Y><S><R><K><E><E><E><C><Q><A><G><A><A><E><M><R><E><Q><F><Y><H><S><C><K><Q><Y><G><I><T><G><E><N><V><R><G><E><L><L><A><L><V><K><D><L><P><S><Q><L><A><E><I><G><A><A><A><Q><Q><S><L><G><E><A><I><D><V><Y><Q><A><S><V><G><F><V><C><E><S><P><T><E><Q><V><L><P><M><L><R><F><V><Q><K><R><G><N><S><T><V><Y><E><W><R><T><G><T><E><P><S><V><V><E><R><P><H><L><E><E><L><P><E><Q><V><A><E><D><A><I><D><W><G><D><F><G><V><E><A><V><S><E><G><T><D><S><G><I><S><A><E><A><A><G><I><D><W><G><I><F><P><E><S><D><S><K><D><P><G><G><D><G><I><D><W><G><D><D><A><V><A><L><Q><I><T><V><L><E><A><G><T><Q><A><P><E><G><V><A><R><G><P><D><A><L><T><L><L><E><Y><T><E><T><R><N><Q><F><L><D><E><L><M><E><L><E><I><F><L><A><Q><R><A><V><E><L><S><E><E><A><D><V><L><S><V><S><Q><F><Q><L><A><P><A><I><L><Q><G><Q><T><K><E><K><M><V><T><M><V><S><V><L><E><D><L><I><G><K><L><T><S><L><Q><L><Q><H><L><F><M><I><L><A><S><P><R><Y><V><D><R><V><T><E><F><L><Q><Q><K><L><K><Q><S><Q><L><L><A><L><K><K><E><L><M><V><Q><K><Q><Q><E><A><L><E><E><Q><A><A><L><E><P><K><L><D><L><L><L><E><K><T><K><E><L><Q><K><L><I><E><A><D><I><S><K><R><Y><S><G><R><P><V><N><L><M><G><T><S><L>
(Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.<BOP>
Q96JB5
Q15833
STXB2_HUMAN
Protein unc-18 homolog B
Homo
<M><A><P><S><G><L><K><A><V><V><G><E><K><I><L><S><G><V><I><R><S><V><K><K><D><G><E><W><K><V><L><I><M><D><H><P><S><M><R><I><L><S><S><C><C><K><M><S><D><I><L><A><E><G><I><T><I><V><E><D><I><N><K><R><R><E><P><I><P><S><L><E><A><I><Y><L><L><S><P><T><E><K><S><V><Q><A><L><I><K><D><F><Q><G><T><P><T><F><T><Y><K><A><A><H><I><F><F><T><D><T><C><P><E><P><L><F><S><E><L><G><R><S><R><L><A><K><V><V><K><T><L><K><E><I><H><L><A><F><L><P><Y><E><A><Q><V><F><S><L><D><A><P><H><S><T><Y><N><L><Y><C><P><F><R><A><E><E><R><T><R><Q><L><E><V><L><A><Q><Q><I><A><T><L><C><A><T><L><Q><E><Y><P><A><I><R><Y><R><K><G><P><E><D><T><A><Q><L><A><H><A><V><L><A><K><L><N><A><F><K><A><D><T><P><S><L><G><E><G><P><E><K><T><R><S><Q><L><L><I><M><D><R><A><A><D><P><V><S><P><L><L><H><E><L><T><F><Q><A><M><A><Y><D><L><L><D><I><E><Q><D><T><Y><R><Y><E><T><T><G><L><S><E><A><R><E><K><A><V><L><L><D><E><D><D><D><L><W><V><E><L><R><H><M><H><I><A><D><V><S><K><K><V><T><E><L><L><R><T><F><C><E><S><K><R><L><T><T><D><K><A><N><I><K><D><L><S><Q><I><L><K><K><M><P><Q><Y><Q><K><E><L><N><K><Y><S><T><H><L><H><L><A><D><D><C><M><K><H><F><K><G><S><V><E><K><L><C><S><V><E><Q><D><L><A><M><G><S><D><A><E><G><E><K><I><K><D><S><M><K><L><I><V><P><V><L><L><D><A><A><V><P><A><Y><D><K><I><R><V><L><L><L><Y><I><L><L><R><N><G><V><S><E><E><N><L><A><K><L><I><Q><H><A><N><V><Q><A><H><S><S><L><I><R><N><L><E><Q><L><G><G><T><V><T><N><P><G><G><S><G><T><S><S><R><L><E><P><R><E><R><M><E><P><T><Y><Q><L><S><R><W><T><P><V><I><K><D><V><M><E><D><A><V><E><D><R><L><D><R><N><L><W><P><F><V><S><D><P><A><P><T><A><S><S><Q><A><A><V><S><A><R><F><G><H><W><H><K><N><K><A><G><I><E><A><R><A><G><P><R><L><I><V><Y><V><M><G><G><V><A><M><S><E><M><R><A><A><Y><E><V><T><R><A><T><E><G><K><W><E><V><L><I><G><S><S><H><I><L><T><P><T><R><F><L><D><D><L><K><A><L><D><K><K><L><E><D><I><A><L><P>
Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.<BOP>
Q15833
Q9Y644
RFNG_HUMAN
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Homo
<M><S><R><A><R><G><A><L><C><R><A><C><L><A><L><A><A><A><L><A><A><L><L><L><L><P><L><P><L><P><R><A><P><A><P><A><R><T><P><A><P><A><P><R><A><P><P><S><R><P><A><A><P><S><L><R><P><D><D><V><F><I><A><V><K><T><T><R><K><N><H><G><P><R><L><R><L><L><L><R><T><W><I><S><R><A><R><Q><Q><T><F><I><F><T><D><G><D><D><P><E><L><E><L><Q><G><G><D><R><V><I><N><T><N><C><S><A><V><R><T><R><Q><A><L><C><C><K><M><S><V><E><Y><D><K><F><I><E><S><G><R><K><W><F><C><H><V><D><D><D><N><Y><V><N><A><R><S><L><L><H><L><L><S><S><F><S><P><S><Q><D><V><Y><L><G><R><P><S><L><D><H><P><I><E><A><T><E><R><V><Q><G><G><R><T><V><T><T><V><K><F><W><F><A><T><G><G><A><G><F><C><L><S><R><G><L><A><L><K><M><S><P><W><A><S><L><G><S><F><M><S><T><A><E><Q><V><R><L><P><D><D><C><T><V><G><Y><I><V><E><G><L><L><G><A><R><L><L><H><S><P><L><F><H><S><H><L><E><N><L><Q><R><L><P><P><D><T><L><L><Q><Q><V><T><L><S><H><G><G><P><E><N><P><H><N><V><V><N><V><A><G><G><F><S><L><H><Q><D><P><T><R><F><K><S><I><H><C><L><L><Y><P><D><T><D><W><C><P><R><Q><K><Q><G><A><P><T><S><R>
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.<BOP>
Q9Y644
Q13185
CBX3_HUMAN
Modifier 2 protein
Homo
<M><A><S><N><K><T><T><L><Q><K><M><G><K><K><Q><N><G><K><S><K><K><V><E><E><A><E><P><E><E><F><V><V><E><K><V><L><D><R><R><V><V><N><G><K><V><E><Y><F><L><K><W><K><G><F><T><D><A><D><N><T><W><E><P><E><E><N><L><D><C><P><E><L><I><E><A><F><L><N><S><Q><K><A><G><K><E><K><D><G><T><K><R><K><S><L><S><D><S><E><S><D><D><S><K><S><K><K><K><R><D><A><A><D><K><P><R><G><F><A><R><G><L><D><P><E><R><I><I><G><A><T><D><S><S><G><E><L><M><F><L><M><K><W><K><D><S><D><E><A><D><L><V><L><A><K><E><A><N><M><K><C><P><Q><I><V><I><A><F><Y><E><E><R><L><T><W><H><S><C><P><E><D><E><A><Q>
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) .<BOP>
Q13185
Q9P299
COPZ2_HUMAN
Zeta-2-coat protein
Homo
<M><Q><R><P><E><A><W><P><R><P><H><P><G><E><G><A><A><A><A><Q><A><G><G><P><A><P><P><A><R><A><G><E><P><S><G><L><R><L><Q><E><P><S><L><Y><T><I><K><A><V><F><I><L><D><N><D><G><R><R><L><L><A><K><Y><Y><D><D><T><F><P><S><M><K><E><Q><M><V><F><E><K><N><V><F><N><K><T><S><R><T><E><S><E><I><A><F><F><G><G><M><T><I><V><Y><K><N><S><I><D><L><F><L><Y><V><V><G><S><S><Y><E><N><E><L><M><L><M><S><V><L><T><C><L><F><E><S><L><N><H><M><L><R><K><N><V><E><K><R><W><L><L><E><N><M><D><G><A><F><L><V><L><D><E><I><V><D><G><G><V><I><L><E><S><D><P><Q><Q><V><I><Q><K><V><N><F><R><A><D><D><G><G><L><T><E><Q><S><V><A><Q><V><L><Q><S><A><K><E><Q><I><K><W><S><L><L><K>
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.<BOP>
Q9P299
P51608
MECP2_HUMAN
Methyl-CpG-binding protein 2
Homo
<M><V><A><G><M><L><G><L><R><E><E><K><S><E><D><Q><D><L><Q><G><L><K><D><K><P><L><K><F><K><K><V><K><K><D><K><K><E><E><K><E><G><K><H><E><P><V><Q><P><S><A><H><H><S><A><E><P><A><E><A><G><K><A><E><T><S><E><G><S><G><S><A><P><A><V><P><E><A><S><A><S><P><K><Q><R><R><S><I><I><R><D><R><G><P><M><Y><D><D><P><T><L><P><E><G><W><T><R><K><L><K><Q><R><K><S><G><R><S><A><G><K><Y><D><V><Y><L><I><N><P><Q><G><K><A><F><R><S><K><V><E><L><I><A><Y><F><E><K><V><G><D><T><S><L><D><P><N><D><F><D><F><T><V><T><G><R><G><S><P><S><R><R><E><Q><K><P><P><K><K><P><K><S><P><K><A><P><G><T><G><R><G><R><G><R><P><K><G><S><G><T><T><R><P><K><A><A><T><S><E><G><V><Q><V><K><R><V><L><E><K><S><P><G><K><L><L><V><K><M><P><F><Q><T><S><P><G><G><K><A><E><G><G><G><A><T><T><S><T><Q><V><M><V><I><K><R><P><G><R><K><R><K><A><E><A><D><P><Q><A><I><P><K><K><R><G><R><K><P><G><S><V><V><A><A><A><A><A><E><A><K><K><K><A><V><K><E><S><S><I><R><S><V><Q><E><T><V><L><P><I><K><K><R><K><T><R><E><T><V><S><I><E><V><K><E><V><V><K><P><L><L><V><S><T><L><G><E><K><S><G><K><G><L><K><T><C><K><S><P><G><R><K><S><K><E><S><S><P><K><G><R><S><S><S><A><S><S><P><P><K><K><E><H><H><H><H><H><H><H><S><E><S><P><K><A><P><V><P><L><L><P><P><L><P><P><P><P><P><E><P><E><S><S><E><D><P><T><S><P><P><E><P><Q><D><L><S><S><S><V><C><K><E><E><K><M><P><R><G><G><S><L><E><S><D><G><C><P><K><E><P><A><K><T><Q><P><A><V><A><T><A><A><T><A><A><E><K><Y><K><H><R><G><E><G><E><R><K><D><I><V><S><S><S><M><P><R><P><N><R><E><E><P><V><D><S><R><T><P><V><T><E><R><V><S>
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).<BOP>
P51608
A0A0C4DH38
HV551_HUMAN
Immunoglobulin heavy variable 5-51
Homo
<M><G><S><T><A><I><L><A><L><L><L><A><V><L><Q><G><V><C><A><E><V><Q><L><V><Q><S><G><A><E><V><K><K><P><G><E><S><L><K><I><S><C><K><G><S><G><Y><S><F><T><S><Y><W><I><G><W><V><R><Q><M><P><G><K><G><L><E><W><M><G><I><I><Y><P><G><D><S><D><T><R><Y><S><P><S><F><Q><G><Q><V><T><I><S><A><D><K><S><I><S><T><A><Y><L><Q><W><S><S><L><K><A><S><D><T><A><M><Y><Y><C><A><R>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0C4DH38
P51955
NEK2_HUMAN
NimA-like protein kinase 1
Homo
<M><P><S><R><A><E><D><Y><E><V><L><Y><T><I><G><T><G><S><Y><G><R><C><Q><K><I><R><R><K><S><D><G><K><I><L><V><W><K><E><L><D><Y><G><S><M><T><E><A><E><K><Q><M><L><V><S><E><V><N><L><L><R><E><L><K><H><P><N><I><V><R><Y><Y><D><R><I><I><D><R><T><N><T><T><L><Y><I><V><M><E><Y><C><E><G><G><D><L><A><S><V><I><T><K><G><T><K><E><R><Q><Y><L><D><E><E><F><V><L><R><V><M><T><Q><L><T><L><A><L><K><E><C><H><R><R><S><D><G><G><H><T><V><L><H><R><D><L><K><P><A><N><V><F><L><D><G><K><Q><N><V><K><L><G><D><F><G><L><A><R><I><L><N><H><D><T><S><F><A><K><T><F><V><G><T><P><Y><Y><M><S><P><E><Q><M><N><R><M><S><Y><N><E><K><S><D><I><W><S><L><G><C><L><L><Y><E><L><C><A><L><M><P><P><F><T><A><F><S><Q><K><E><L><A><G><K><I><R><E><G><K><F><R><R><I><P><Y><R><Y><S><D><E><L><N><E><I><I><T><R><M><L><N><L><K><D><Y><H><R><P><S><V><E><E><I><L><E><N><P><L><I><A><D><L><V><A><D><E><Q><R><R><N><L><E><R><R><G><R><Q><L><G><E><P><E><K><S><Q><D><S><S><P><V><L><S><E><L><K><L><K><E><I><Q><L><Q><E><R><E><R><A><L><K><A><R><E><E><R><L><E><Q><K><E><Q><E><L><C><V><R><E><R><L><A><E><D><K><L><A><R><A><E><N><L><L><K><N><Y><S><L><L><K><E><R><K><F><L><S><L><A><S><N><P><E><L><L><N><L><P><S><S><V><I><K><K><K><V><H><F><S><G><E><S><K><E><N><I><M><R><S><E><N><S><E><S><Q><L><T><S><K><S><K><C><K><D><L><K><K><R><L><H><A><A><Q><L><R><A><Q><A><L><S><D><I><E><K><N><Y><Q><L><K><S><R><Q><I><L><G><M><R>
Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells.<BOP>
P51955
P32239
GASR_HUMAN
Cholecystokinin-2 receptor
Homo
<M><E><L><L><K><L><N><R><S><V><Q><G><T><G><P><G><P><G><A><S><L><C><R><P><G><A><P><L><L><N><S><S><S><V><G><N><L><S><C><E><P><P><R><I><R><G><A><G><T><R><E><L><E><L><A><I><R><I><T><L><Y><A><V><I><F><L><M><S><V><G><G><N><M><L><I><I><V><V><L><G><L><S><R><R><L><R><T><V><T><N><A><F><L><L><S><L><A><V><S><D><L><L><L><A><V><A><C><M><P><F><T><L><L><P><N><L><M><G><T><F><I><F><G><T><V><I><C><K><A><V><S><Y><L><M><G><V><S><V><S><V><S><T><L><S><L><V><A><I><A><L><E><R><Y><S><A><I><C><R><P><L><Q><A><R><V><W><Q><T><R><S><H><A><A><R><V><I><V><A><T><W><L><L><S><G><L><L><M><V><P><Y><P><V><Y><T><V><V><Q><P><V><G><P><R><V><L><Q><C><V><H><R><W><P><S><A><R><V><R><Q><T><W><S><V><L><L><L><L><L><L><F><F><I><P><G><V><V><M><A><V><A><Y><G><L><I><S><R><E><L><Y><L><G><L><R><F><D><G><D><S><D><S><D><S><Q><S><R><V><R><N><Q><G><G><L><P><G><A><V><H><Q><N><G><R><C><R><P><E><T><G><A><V><G><E><D><S><D><G><C><Y><V><Q><L><P><R><S><R><P><A><L><E><L><T><A><L><T><A><P><G><P><G><S><G><S><R><P><T><Q><A><K><L><L><A><K><K><R><V><V><R><M><L><L><V><I><V><V><L><F><F><L><C><W><L><P><V><Y><S><A><N><T><W><R><A><F><D><G><P><G><A><H><R><A><L><S><G><A><P><I><S><F><I><H><L><L><S><Y><A><S><A><C><V><N><P><L><V><Y><C><F><M><H><R><R><F><R><Q><A><C><L><E><T><C><A><R><C><C><P><R><P><P><R><A><R><P><R><A><L><P><D><E><D><P><P><T><P><S><I><A><S><L><S><R><L><S><Y><T><T><I><S><T><L><G><P><G>
Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.<BOP>
P32239
P09871
C1S_HUMAN
Complement C1s subcomponent light chain
Homo
<M><W><C><I><V><L><F><S><L><L><A><W><V><Y><A><E><P><T><M><Y><G><E><I><L><S><P><N><Y><P><Q><A><Y><P><S><E><V><E><K><S><W><D><I><E><V><P><E><G><Y><G><I><H><L><Y><F><T><H><L><D><I><E><L><S><E><N><C><A><Y><D><S><V><Q><I><I><S><G><D><T><E><E><G><R><L><C><G><Q><R><S><S><N><N><P><H><S><P><I><V><E><E><F><Q><V><P><Y><N><K><L><Q><V><I><F><K><S><D><F><S><N><E><E><R><F><T><G><F><A><A><Y><Y><V><A><T><D><I><N><E><C><T><D><F><V><D><V><P><C><S><H><F><C><N><N><F><I><G><G><Y><F><C><S><C><P><P><E><Y><F><L><H><D><D><M><K><N><C><G><V><N><C><S><G><D><V><F><T><A><L><I><G><E><I><A><S><P><N><Y><P><K><P><Y><P><E><N><S><R><C><E><Y><Q><I><R><L><E><K><G><F><Q><V><V><V><T><L><R><R><E><D><F><D><V><E><A><A><D><S><A><G><N><C><L><D><S><L><V><F><V><A><G><D><R><Q><F><G><P><Y><C><G><H><G><F><P><G><P><L><N><I><E><T><K><S><N><A><L><D><I><I><F><Q><T><D><L><T><G><Q><K><K><G><W><K><L><R><Y><H><G><D><P><M><P><C><P><K><E><D><T><P><N><S><V><W><E><P><A><K><A><K><Y><V><F><R><D><V><V><Q><I><T><C><L><D><G><F><E><V><V><E><G><R><V><G><A><T><S><F><Y><S><T><C><Q><S><N><G><K><W><S><N><S><K><L><K><C><Q><P><V><D><C><G><I><P><E><S><I><E><N><G><K><V><E><D><P><E><S><T><L><F><G><S><V><I><R><Y><T><C><E><E><P><Y><Y><Y><M><E><N><G><G><G><G><E><Y><H><C><A><G><N><G><S><W><V><N><E><V><L><G><P><E><L><P><K><C><V><P><V><C><G><V><P><R><E><P><F><E><E><K><Q><R><I><I><G><G><S><D><A><D><I><K><N><F><P><W><Q><V><F><F><D><N><P><W><A><G><G><A><L><I><N><E><Y><W><V><L><T><A><A><H><V><V><E><G><N><R><E><P><T><M><Y><V><G><S><T><S><V><Q><T><S><R><L><A><K><S><K><M><L><T><P><E><H><V><F><I><H><P><G><W><K><L><L><E><V><P><E><G><R><T><N><F><D><N><D><I><A><L><V><R><L><K><D><P><V><K><M><G><P><T><V><S><P><I><C><L><P><G><T><S><S><D><Y><N><L><M><D><G><D><L><G><L><I><S><G><W><G><R><T><E><K><R><D><R><A><V><R><L><K><A><A><R><L><P><V><A><P><L><R><K><C><K><E><V><K><V><E><K><P><T><A><D><A><E><A><Y><V><F><T><P><N><M><I><C><A><G><G><E><K><G><M><D><S><C><K><G><D><S><G><G><A><F><A><V><Q><D><P><N><D><K><T><K><F><Y><A><A><G><L><V><S><W><G><P><Q><C><G><T><Y><G><L><Y><T><R><V><K><N><Y><V><D><W><I><M><K><T><M><Q><E><N><S><T><P><R><E><D>
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.<BOP>
P09871
Q96Q83
ALKB3_HUMAN
Prostate cancer antigen 1
Homo
<M><E><E><K><R><R><R><A><R><V><Q><G><A><W><A><A><P><V><K><S><Q><A><I><A><Q><P><A><T><T><A><K><S><H><L><H><Q><K><P><G><Q><T><W><K><N><K><E><H><H><L><S><D><R><E><F><V><F><K><E><P><Q><Q><V><V><R><R><A><P><E><P><R><V><I><D><R><E><G><V><Y><E><I><S><L><S><P><T><G><V><S><R><V><C><L><Y><P><G><F><V><D><V><K><E><A><D><W><I><L><E><Q><L><C><Q><D><V><P><W><K><Q><R><T><G><I><R><E><D><I><T><Y><Q><Q><P><R><L><T><A><W><Y><G><E><L><P><Y><T><Y><S><R><I><T><M><E><P><N><P><H><W><H><P><V><L><R><T><L><K><N><R><I><E><E><N><T><G><H><T><F><N><S><L><L><C><N><L><Y><R><N><E><K><D><S><V><D><W><H><S><D><D><E><P><S><L><G><R><C><P><I><I><A><S><L><S><F><G><A><T><R><T><F><E><M><R><K><K><P><P><P><E><E><N><G><D><Y><T><Y><V><E><R><V><K><I><P><L><D><H><G><T><L><L><I><M><E><G><A><T><Q><A><D><W><Q><H><R><V><P><K><E><Y><H><S><R><E><P><R><V><N><L><T><F><R><T><V><Y><P><D><P><R><G><A><P><W>
Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) . Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation . Has a strong preference for single-stranded DNA . Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 . Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA . Also acts on RNA . Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons . Requires molecular oxygen, alpha-ketoglutarate and iron .<BOP>
Q96Q83
Q96M29
TEKT5_HUMAN
Tektin-5
Homo
<M><E><F><L><G><T><T><Q><T><A><S><Y><C><G><P><K><K><C><C><G><L><T><S><L><P><A><V><Q><A><P><V><I><Q><E><C><Y><Q><P><Y><Y><L><P><G><Y><R><Y><L><N><S><W><R><P><S><L><F><Y><K><I><A><N><V><Q><T><C><P><D><E><S><T><S><T><L><R><P><P><T><I><L><P><T><L><R><S><A><L><F><S><R><Y><S><P><H><D><W><D><Q><S><N><Q><L><Q><V><R><G><A><E><A><S><R><L><W><A><S><R><L><T><D><D><S><M><R><L><L><Q><D><K><D><Q><L><T><H><Q><M><Q><E><G><T><C><R><N><L><G><Q><R><L><S><D><I><G><F><W><K><S><E><L><S><Y><E><L><D><R><L><L><T><E><N><Q><N><L><E><T><V><K><R><R><L><E><C><A><A><N><E><V><N><C><P><L><Q><V><A><L><E><C><L><Y><H><R><E><K><R><I><G><I><D><L><V><H><D><N><V><E><K><N><L><I><R><E><V><D><L><L><K><C><C><Q><E><Q><M><R><K><L><A><Q><R><I><D><I><Q><M><R><D><N><R><D><A><Q><H><V><L><E><R><D><L><E><D><K><S><S><A><Q><C><I><D><E><K><C><F><N><L><R><N><T><S><D><C><I><S><F><F><H><G><M><E><K><I><D><G><T><I><S><V><P><E><T><W><A><K><F><S><N><D><N><I><K><H><S><Q><N><M><R><A><N><S><I><Q><L><R><E><E><A><E><H><L><F><E><T><L><S><D><Q><M><W><R><Q><F><T><D><T><N><L><A><F><N><A><R><I><S><E><V><T><D><V><K><N><K><L><Q><T><Q><L><A><K><T><L><Q><E><I><F><Q><A><E><N><T><I><M><L><L><E><R><S><I><M><A><K><E><G><P><L><K><V><A><Q><T><R><L><E><C><R><T><R><R><P><N><M><E><L><C><R><D><I><P><Q><L><K><L><V><N><E><V><F><T><I><D><D><T><L><Q><T><L><K><L><R><L><R><E><T><Q><D><T><L><Q><L><L><V><M><T><K><C><R><L><E><H><E><L><A><I><K><A><N><T><L><C><I><D><K><E><K><C><M><G><M><R><K><T><F><P><C><T><P><R><L><V><G><H><T>
May be a structural component of the sperm flagellum.<BOP>
Q96M29
Q86SQ9
DHDDS_HUMAN
Epididymis tissue protein Li 189m
Homo
<M><S><W><I><K><E><G><E><L><S><L><W><E><R><F><C><A><N><I><I><K><A><G><P><M><P><K><H><I><A><F><I><M><D><G><N><R><R><Y><A><K><K><C><Q><V><E><R><Q><E><G><H><S><Q><G><F><N><K><L><A><E><T><L><R><W><C><L><N><L><G><I><L><E><V><T><V><Y><A><F><S><I><E><N><F><K><R><S><K><S><E><V><D><G><L><M><D><L><A><R><Q><K><F><S><R><L><M><E><E><K><E><K><L><Q><K><H><G><V><C><I><R><V><L><G><D><L><H><L><L><P><L><D><L><Q><E><L><I><A><Q><A><V><Q><A><T><K><N><Y><N><K><C><F><L><N><V><C><F><A><Y><T><S><R><H><E><I><S><N><A><V><R><E><M><A><W><G><V><E><Q><G><L><L><D><P><S><D><I><S><E><S><L><L><D><K><C><L><Y><T><N><R><S><P><H><P><D><I><L><I><R><T><S><G><E><V><R><L><S><D><F><L><L><W><Q><T><S><H><S><C><L><V><F><Q><P><V><L><W><P><E><Y><T><F><W><N><L><F><E><A><I><L><Q><F><Q><M><N><H><S><V><L><Q><K><A><R><D><M><Y><A><E><E><R><K><R><Q><Q><L><E><R><D><Q><A><T><V><T><E><Q><L><L><R><E><G><L><Q><A><S><G><D><A><Q><L><R><R><T><R><L><H><K><L><S><A><R><R><E><E><R><V><Q><G><F><L><Q><A><L><E><L><K><R><A><D><W><L><A><R><L><G><T><A><S><A>
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) . Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length . Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol .<BOP>
Q86SQ9
Q9UBK7
RBL2A_HUMAN
Rab-like protein 2A
Homo
<M><A><E><D><K><T><K><P><S><E><L><D><Q><G><K><Y><D><A><D><D><N><V><K><I><I><C><L><G><D><S><A><V><G><K><S><K><L><M><E><R><F><L><M><D><G><F><Q><P><Q><Q><L><S><T><Y><A><L><T><L><Y><K><H><T><A><T><V><D><G><K><T><I><L><V><D><F><W><D><T><A><G><Q><E><R><F><Q><S><M><H><A><S><Y><Y><H><K><A><H><A><C><I><M><V><F><D><I><Q><R><K><V><T><Y><R><N><L><S><T><W><Y><T><E><L><R><E><F><R><P><E><I><P><C><I><V><V><A><N><K><I><D><D><I><N><V><T><Q><K><S><F><N><F><A><K><K><F><S><L><P><L><Y><F><V><S><A><A><D><G><T><N><V><V><K><L><F><N><D><A><I><R><L><A><V><S><Y><K><Q><N><S><Q><D><F><M><D><E><I><F><Q><E><L><E><N><F><S><L><E><Q><E><E><E><D><V><P><D><Q><E><Q><S><S><S><I><E><T><P><S><E><E><V><A><S><P><H><S>
Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.<BOP>
Q9UBK7
Q01581
HMCS1_HUMAN
3-hydroxy-3-methylglutaryl coenzyme A synthase
Homo
<M><P><G><S><L><P><L><N><A><E><A><C><W><P><K><D><V><G><I><V><A><L><E><I><Y><F><P><S><Q><Y><V><D><Q><A><E><L><E><K><Y><D><G><V><D><A><G><K><Y><T><I><G><L><G><Q><A><K><M><G><F><C><T><D><R><E><D><I><N><S><L><C><M><T><V><V><Q><N><L><M><E><R><N><N><L><S><Y><D><C><I><G><R><L><E><V><G><T><E><T><I><I><D><K><S><K><S><V><K><T><N><L><M><Q><L><F><E><E><S><G><N><T><D><I><E><G><I><D><T><T><N><A><C><Y><G><G><T><A><A><V><F><N><A><V><N><W><I><E><S><S><S><W><D><G><R><Y><A><L><V><V><A><G><D><I><A><V><Y><A><T><G><N><A><R><P><T><G><G><V><G><A><V><A><L><L><I><G><P><N><A><P><L><I><F><E><R><G><L><R><G><T><H><M><Q><H><A><Y><D><F><Y><K><P><D><M><L><S><E><Y><P><I><V><D><G><K><L><S><I><Q><C><Y><L><S><A><L><D><R><C><Y><S><V><Y><C><K><K><I><H><A><Q><W><Q><K><E><G><N><D><K><D><F><T><L><N><D><F><G><F><M><I><F><H><S><P><Y><C><K><L><V><Q><K><S><L><A><R><M><L><L><N><D><F><L><N><D><Q><N><R><D><K><N><S><I><Y><S><G><L><E><A><F><G><D><V><K><L><E><D><T><Y><F><D><R><D><V><E><K><A><F><M><K><A><S><S><E><L><F><S><Q><K><T><K><A><S><L><L><V><S><N><Q><N><G><N><M><Y><T><S><S><V><Y><G><S><L><A><S><V><L><A><Q><Y><S><P><Q><Q><L><A><G><K><R><I><G><V><F><S><Y><G><S><G><L><A><A><T><L><Y><S><L><K><V><T><Q><D><A><T><P><G><S><A><L><D><K><I><T><A><S><L><C><D><L><K><S><R><L><D><S><R><T><G><V><A><P><D><V><F><A><E><N><M><K><L><R><E><D><T><H><H><L><V><N><Y><I><P><Q><G><S><I><D><S><L><F><E><G><T><W><Y><L><V><R><V><D><E><K><H><R><R><T><Y><A><R><R><P><T><P><N><D><D><T><L><D><E><G><V><G><L><V><H><S><N><I><A><T><E><H><I><P><S><P><A><K><K><V><P><R><L><P><A><T><A><A><E><P><E><A><A><V><I><S><N><G><E><H>
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.<BOP>
Q01581
Q9Y5L5
LENEP_HUMAN
Lens epithelial cell protein LEP503
Homo
<M><Q><P><R><T><Q><P><L><A><Q><T><L><P><F><F><L><G><G><A><P><R><D><T><G><L><R><V><P><V><I><K><M><G><T><G><W><E><G><F><Q><R><T><L><K><E><V><A><Y><I><L><L><C><C><W><C><I><K><E><L><L><D>
May play a role in lens epithelial cell differentiation.<BOP>
Q9Y5L5
Q9NSC5
HOME3_HUMAN
Homer protein homolog 3
Homo
<M><S><T><A><R><E><Q><P><I><F><S><T><R><A><H><V><F><Q><I><D><P><A><T><K><R><N><W><I><P><A><G><K><H><A><L><T><V><S><Y><F><Y><D><A><T><R><N><V><Y><R><I><I><S><I><G><G><A><K><A><I><I><N><S><T><V><T><P><N><M><T><F><T><K><T><S><Q><K><F><G><Q><W><A><D><S><R><A><N><T><V><Y><G><L><G><F><A><S><E><Q><H><L><T><Q><F><A><E><K><F><Q><E><V><K><E><A><A><R><L><A><R><E><K><S><Q><D><G><G><E><L><T><S><P><A><L><G><L><A><S><H><Q><V><P><P><S><P><L><V><S><A><N><G><P><G><E><E><K><L><F><R><S><Q><S><A><D><A><P><G><P><T><E><R><E><R><L><K><K><M><L><S><E><G><S><V><G><E><V><Q><W><E><A><E><F><F><A><L><Q><D><S><N><N><K><L><A><G><A><L><R><E><A><N><A><A><A><A><Q><W><R><Q><Q><L><E><A><Q><R><A><E><A><E><R><L><R><Q><R><V><A><E><L><E><A><Q><A><A><S><E><V><T><P><T><G><E><K><E><G><L><G><Q><G><Q><S><L><E><Q><L><E><A><L><V><Q><T><K><D><Q><E><I><Q><T><L><K><S><Q><T><G><G><P><R><E><A><L><E><A><A><E><R><E><E><T><Q><Q><K><V><Q><D><L><E><T><R><N><A><E><L><E><H><Q><L><R><A><M><E><R><S><L><E><E><A><R><A><E><R><E><R><A><R><A><E><V><G><R><A><A><Q><L><L><D><V><S><L><F><E><L><S><E><L><R><E><G><L><A><R><L><A><E><A><A><P>
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA .<BOP>
Q9NSC5
P40205
NCYM_HUMAN
N-myc opposite strand
Homo
<M><Q><H><P><P><C><E><P><G><N><C><L><S><L><K><E><K><K><I><T><E><G><S><G><G><V><C><W><G><G><E><T><D><A><S><N><P><A><P><A><L><T><A><C><C><A><A><E><R><E><A><N><V><E><Q><G><L><A><G><R><L><L><L><C><N><Y><E><R><R><V><V><R><R><C><K><I><A><G><R><G><R><A><P><L><G><T><R><P><L><D><V><S><S><F><K><L><K><E><E><G><R><P><P><C><L><K><I><N><K>
Regulates stability of MYCN in neuroblastoma cells by inhibiting GSK3B-mediated MYCN phosphorylation. Inhibits GSK3B activity by promoting its phosphorylation at 'Ser-9' .<BOP>
P40205
Q9NZQ9
TMOD4_HUMAN
Skeletal muscle tropomodulin
Homo
<M><S><S><Y><Q><K><E><L><E><K><Y><R><D><I><D><E><D><E><I><L><R><T><L><S><P><E><E><L><E><Q><L><D><C><E><L><Q><E><M><D><P><E><N><M><L><L><P><A><G><L><R><Q><R><D><Q><T><K><K><S><P><T><G><P><L><D><R><E><A><L><L><Q><Y><L><E><Q><Q><A><L><E><V><K><E><R><D><D><L><V><P><F><T><G><E><K><K><G><K><P><Y><I><Q><P><K><R><E><I><P><A><E><E><Q><I><T><L><E><P><E><L><E><E><A><L><A><H><A><T><D><A><E><M><C><D><I><A><A><I><L><D><M><Y><T><L><M><S><N><K><Q><Y><Y><D><A><L><C><S><G><E><I><C><N><T><E><G><I><S><S><V><V><Q><P><D><K><Y><K><P><V><P><D><E><P><P><N><P><T><N><I><E><E><I><L><K><R><V><R><S><N><D><K><E><L><E><E><V><N><L><N><N><I><Q><D><I><P><I><P><M><L><S><E><L><C><E><A><M><K><A><N><T><Y><V><R><S><F><S><L><V><A><T><R><S><G><D><P><I><A><N><A><V><A><D><M><L><R><E><N><R><S><L><Q><S><L><N><I><E><S><N><F><I><S><S><T><G><L><M><A><V><L><K><A><V><R><E><N><A><T><L><T><E><L><R><V><D><N><Q><R><Q><W><P><G><D><A><V><E><M><E><M><A><T><V><L><E><Q><C><P><S><I><V><R><F><G><Y><H><F><T><Q><Q><G><P><R><A><R><A><A><Q><A><M><T><R><N><N><E><L><R><R><Q><Q><K><K><R>
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.<BOP>
Q9NZQ9
P11161
EGR2_HUMAN
Zinc finger protein Krox-20
Homo
<M><M><T><A><K><A><V><D><K><I><P><V><T><L><S><G><F><V><H><Q><L><S><D><N><I><Y><P><V><E><D><L><A><A><T><S><V><T><I><F><P><N><A><E><L><G><G><P><F><D><Q><M><N><G><V><A><G><D><G><M><I><N><I><D><M><T><G><E><K><R><S><L><D><L><P><Y><P><S><S><F><A><P><V><S><A><P><R><N><Q><T><F><T><Y><M><G><K><F><S><I><D><P><Q><Y><P><G><A><S><C><Y><P><E><G><I><I><N><I><V><S><A><G><I><L><Q><G><V><T><S><P><A><S><T><T><A><S><S><S><V><T><S><A><S><P><N><P><L><A><T><G><P><L><G><V><C><T><M><S><Q><T><Q><P><D><L><D><H><L><Y><S><P><P><P><P><P><P><P><Y><S><G><C><A><G><D><L><Y><Q><D><P><S><A><F><L><S><A><A><T><T><S><T><S><S><S><L><A><Y><P><P><P><P><S><Y><P><S><P><K><P><A><T><D><P><G><L><F><P><M><I><P><D><Y><P><G><F><F><P><S><Q><C><Q><R><D><L><H><G><T><A><G><P><D><R><K><P><F><P><C><P><L><D><T><L><R><V><P><P><P><L><T><P><L><S><T><I><R><N><F><T><L><G><G><P><S><A><G><V><T><G><P><G><A><S><G><G><S><E><G><P><R><L><P><G><S><S><S><A><A><A><A><A><A><A><A><A><A><Y><N><P><H><H><L><P><L><R><P><I><L><R><P><R><K><Y><P><N><R><P><S><K><T><P><V><H><E><R><P><Y><P><C><P><A><E><G><C><D><R><R><F><S><R><S><D><E><L><T><R><H><I><R><I><H><T><G><H><K><P><F><Q><C><R><I><C><M><R><N><F><S><R><S><D><H><L><T><T><H><I><R><T><H><T><G><E><K><P><F><A><C><D><Y><C><G><R><K><F><A><R><S><D><E><R><K><R><H><T><K><I><H><L><R><Q><K><E><R><K><S><S><A><P><S><A><S><V><P><A><P><S><T><A><S><C><S><G><G><V><Q><P><G><G><T><L><C><S><S><N><S><S><S><L><G><G><G><P><L><A><P><C><S><S><R><T><R><T><P>
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.<BOP>
P11161
A6NHN0
OTOL1_HUMAN
Otolin-1
Homo
<M><W><M><F><S><W><L><C><A><I><L><I><I><L><A><I><A><G><M><N><T><I><A><K><T><T><P><H><T><K><F><T><K><K><S><E><E><R><E><M><P><K><G><L><K><P><S><S><G><P><P><P><E><E><E><E><T><L><F><T><E><M><A><E><M><A><E><P><I><T><K><P><S><A><L><D><S><V><F><G><T><A><T><L><S><P><F><E><N><F><T><L><D><P><A><D><F><F><L><N><C><C><D><C><C><S><P><V><P><G><Q><K><G><E><P><G><E><T><G><Q><P><G><P><K><G><E><A><G><N><L><G><I><P><G><P><P><G><V><V><G><P><Q><G><P><R><G><Y><K><G><E><K><G><L><K><G><E><R><G><D><Q><G><V><P><G><Y><P><G><K><P><G><A><Q><G><E><P><G><P><K><G><D><K><G><N><I><G><L><G><G><V><K><G><Q><K><G><S><K><G><D><T><C><G><N><C><T><K><G><E><K><G><D><Q><G><A><M><G><S><P><G><L><H><G><G><P><G><A><K><G><E><K><G><E><M><G><E><K><G><E><M><G><D><K><G><C><C><G><D><S><G><E><R><G><G><K><G><Q><K><G><E><G><G><M><K><G><E><K><G><S><K><G><D><S><G><M><E><G><K><S><G><R><N><G><L><P><G><A><K><G><D><P><G><I><K><G><E><K><G><E><L><G><P><P><G><L><L><G><P><T><G><P><K><G><D><I><G><N><K><G><V><R><G><P><T><G><K><K><G><S><R><G><F><K><G><S><K><G><E><L><A><R><V><P><R><S><A><F><S><A><G><L><S><K><P><F><P><P><P><N><I><P><I><K><F><E><K><I><L><Y><N><D><Q><G><N><Y><S><P><V><T><G><K><F><N><C><S><I><P><G><T><Y><V><F><S><Y><H><I><T><V><R><G><R><P><A><R><I><S><L><V><A><Q><N><K><K><Q><F><K><S><R><E><T><L><Y><G><Q><E><I><D><Q><A><S><L><L><V><I><L><K><L><S><A><G><D><Q><V><W><L><E><V><S><K><D><W><N><G><V><Y><V><S><A><E><D><D><S><I><F><T><G><F><L><L><Y><P><E><E><T><S><G><I><S><P>
Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics.<BOP>
A6NHN0
O15213
WDR46_HUMAN
WD repeat-containing protein BING4
Homo
<M><E><T><A><P><K><P><G><K><D><V><P><P><K><K><D><K><L><Q><T><K><R><K><K><P><R><R><Y><W><E><E><E><T><V><P><T><T><A><G><A><S><P><G><P><P><R><N><K><K><N><R><E><L><R><P><Q><R><P><K><N><A><Y><I><L><K><K><S><R><I><S><K><K><P><Q><V><P><K><K><P><R><E><W><K><N><P><E><S><Q><R><G><L><S><G><T><Q><D><P><F><P><G><P><A><P><V><P><V><E><V><V><Q><K><F><C><R><I><D><K><S><R><K><L><P><H><S><K><A><K><T><R><S><R><L><E><V><A><E><A><E><E><E><E><T><S><I><K><A><A><R><S><E><L><L><L><A><E><E><P><G><F><L><E><G><E><D><G><E><D><T><A><K><I><C><Q><A><D><I><V><E><A><V><D><I><A><S><A><A><K><H><F><D><L><N><L><R><Q><F><G><P><Y><R><L><N><Y><S><R><T><G><R><H><L><A><F><G><G><R><R><G><H><V><A><A><L><D><W><V><T><K><K><L><M><C><E><I><N><V><M><E><A><V><R><D><I><R><F><L><H><S><E><A><L><L><A><V><A><Q><N><R><W><L><H><I><Y><D><N><Q><G><I><E><L><H><C><I><R><R><C><D><R><V><T><R><L><E><F><L><P><F><H><F><L><L><A><T><A><S><E><T><G><F><L><T><Y><L><D><V><S><V><G><K><I><V><A><A><L><N><A><R><A><G><R><L><D><V><M><S><Q><N><P><Y><N><A><V><I><H><L><G><H><S><N><G><T><V><S><L><W><S><P><A><M><K><E><P><L><A><K><I><L><C><H><R><G><G><V><R><A><V><A><V><D><S><T><G><T><Y><M><A><T><S><G><L><D><H><Q><L><K><I><F><D><L><R><G><T><Y><Q><P><L><S><T><R><T><L><P><H><G><A><G><H><L><A><F><S><Q><R><G><L><L><V><A><G><M><G><D><V><V><N><I><W><A><G><Q><G><K><A><S><P><P><S><L><E><Q><P><Y><L><T><H><R><L><S><G><P><V><H><G><L><Q><F><C><P><F><E><D><V><L><G><V><G><H><T><G><G><I><T><S><M><L><V><P><G><A><G><E><P><N><F><D><G><L><E><S><N><P><Y><R><S><R><K><Q><R><Q><E><W><E><V><K><A><L><L><E><K><V><P><A><E><L><I><C><L><D><P><R><A><L><A><E><V><D><V><I><S><L><E><Q><G><K><K><E><Q><I><E><R><L><G><Y><D><P><Q><A><K><A><P><F><Q><P><K><P><K><Q><K><G><R><S><S><T><A><S><L><V><K><R><K><R><K><V><M><D><E><E><H><R><D><K><V><R><Q><S><L><Q><Q><Q><H><H><K><E><A><K><A><K><P><T><G><A><R><P><S><A><L><D><R><F><V><R>
Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.<BOP>
O15213
Q8N2K1
UB2J2_HUMAN
Non-canonical ubiquitin-conjugating enzyme 2
Homo
<M><S><S><T><S><S><K><R><A><P><T><T><A><T><Q><R><L><K><Q><D><Y><L><R><I><K><K><D><P><V><P><Y><I><C><A><E><P><L><P><S><N><I><L><E><W><H><Y><V><V><R><G><P><E><M><T><P><Y><E><G><G><Y><Y><H><G><K><L><I><F><P><R><E><F><P><F><K><P><P><S><I><Y><M><I><T><P><N><G><R><F><K><C><N><T><R><L><C><L><S><I><T><D><F><H><P><D><T><W><N><P><A><W><S><V><S><T><I><L><T><G><L><L><S><F><M><V><E><K><G><P><T><L><G><S><I><E><T><S><D><F><T><K><R><Q><L><A><V><Q><S><L><A><F><N><L><K><D><K><V><F><C><E><L><F><P><E><V><V><E><E><I><K><Q><K><Q><K><A><Q><D><E><L><S><S><R><P><Q><T><L><P><L><P><D><V><V><P><D><G><E><T><H><L><V><Q><N><G><I><Q><L><L><N><G><H><A><P><G><A><V><P><N><L><A><G><L><Q><Q><A><N><R><H><H><G><L><L><G><G><A><L><A><N><L><F><V><I><V><G><F><A><A><F><A><Y><T><V><K><Y><V><L><R><S><I><A><Q><E>
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).<BOP>
Q8N2K1
Q03519
TAP2_HUMAN
Really interesting new gene 11 protein
Homo
<M><R><L><P><D><L><R><P><W><T><S><L><L><L><V><D><A><A><L><L><W><L><L><Q><G><P><L><G><T><L><L><P><Q><G><L><P><G><L><W><L><E><G><T><L><R><L><G><G><L><W><G><L><L><K><L><R><G><L><L><G><F><V><G><T><L><L><L><P><L><C><L><A><T><P><L><T><V><S><L><R><A><L><V><A><G><A><S><R><A><P><P><A><R><V><A><S><A><P><W><S><W><L><L><V><G><Y><G><A><A><G><L><S><W><S><L><W><A><V><L><S><P><P><G><A><Q><E><K><E><Q><D><Q><V><N><N><K><V><L><M><W><R><L><L><K><L><S><R><P><D><L><P><L><L><V><A><A><F><F><F><L><V><L><A><V><L><G><E><T><L><I><P><H><Y><S><G><R><V><I><D><I><L><G><G><D><F><D><P><H><A><F><A><S><A><I><F><F><M><C><L><F><S><F><G><S><S><L><S><A><G><C><R><G><G><C><F><T><Y><T><M><S><R><I><N><L><R><I><R><E><Q><L><F><S><S><L><L><R><Q><D><L><G><F><F><Q><E><T><K><T><G><E><L><N><S><R><L><S><S><D><T><T><L><M><S><N><W><L><P><L><N><A><N><V><L><L><R><S><L><V><K><V><V><G><L><Y><G><F><M><L><S><I><S><P><R><L><T><L><L><S><L><L><H><M><P><F><T><I><A><A><E><K><V><Y><N><T><R><H><Q><E><V><L><R><E><I><Q><D><A><V><A><R><A><G><Q><V><V><R><E><A><V><G><G><L><Q><T><V><R><S><F><G><A><E><E><H><E><V><C><R><Y><K><E><A><L><E><Q><C><R><Q><L><Y><W><R><R><D><L><E><R><A><L><Y><L><L><V><R><R><V><L><H><L><G><V><Q><M><L><M><L><S><C><G><L><Q><Q><M><Q><D><G><E><L><T><Q><G><S><L><L><S><F><M><I><Y><Q><E><S><V><G><S><Y><V><Q><T><L><V><Y><I><Y><G><D><M><L><S><N><V><G><A><A><E><K><V><F><S><Y><M><D><R><Q><P><N><L><P><S><P><G><T><L><A><P><T><T><L><Q><G><V><V><K><F><Q><D><V><S><F><A><Y><P><N><R><P><D><R><P><V><L><K><G><L><T><F><T><L><R><P><G><E><V><T><A><L><V><G><P><N><G><S><G><K><S><T><V><A><A><L><L><Q><N><L><Y><Q><P><T><G><G><Q><V><L><L><D><E><K><P><I><S><Q><Y><E><H><C><Y><L><H><S><Q><V><V><S><V><G><Q><E><P><V><L><F><S><G><S><V><R><N><N><I><A><Y><G><L><Q><S><C><E><D><D><K><V><M><A><A><A><Q><A><A><H><A><D><D><F><I><Q><E><M><E><H><G><I><Y><T><D><V><G><E><K><G><S><Q><L><A><A><G><Q><K><Q><R><L><A><I><A><R><A><L><V><R><D><P><R><V><L><I><L><D><E><A><T><S><A><L><D><V><Q><C><E><Q><A><L><Q><D><W><N><S><R><G><D><R><T><V><L><V><I><A><H><R><L><Q><T><V><Q><R><A><H><Q><I><L><V><L><Q><E><G><K><L><Q><K><L><A><Q><L>
ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules . Uses the chemical energy of ATP to export peptides against the concentration gradient . During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle . Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Pro
Q03519
Q5JS54
PSMG4_HUMAN
Proteasome assembly chaperone 4
Homo
<M><E><G><L><V><V><A><A><G><G><D><V><S><L><H><N><F><S><A><R><L><W><E><Q><L><V><H><F><H><V><M><R><L><T><D><S><L><F><L><W><V><G><A><T><P><H><L><R><N><L><A><V><A><M><C><S><R><Y><D><S><I><P><V><S><T><S><L><L><G><D><T><S><D><T><T><S><T><G><L><A><Q><R><L><A><R><K><T><N><K><Q><V><F><V><S><Y><N><L><Q><N><T><D><S><N><F><A><L><L><V><E><N><R><I><K><E><E><M><E><A><F><P><E><K><F>
Chaperone protein which promotes assembly of the 20S proteasome.<BOP>
Q5JS54
Q6ZS72
PEAK3_HUMAN
Protein PEAK3
Homo
<M><S><S><P><E><P><P><T><E><P><P><E><P><D><N><P><T><W><S><T><Q><P><T><Y><S><N><L><G><Q><I><R><A><H><L><L><P><S><K><A><C><R><L><R><T><P><G><S><L><S><T><N><P><E><P><L><P><P><P><L><P><K><K><I><L><T><R><T><Q><S><L><P><T><R><R><T><L><H><P><S><S><I><Q><V><Q><P><P><R><R><P><F><L><G><S><H><S><V><D><K><S><Q><A><A><V><G><P><A><C><L><P><A><E><L><T><F><G><P><A><D><A><P><L><G><L><S><L><R><D><L><H><S><P><E><A><V><H><T><A><L><A><A><R><Q><L><Q><G><L><R><T><I><Y><A><R><L><R><A><R><L><M><G><G><H><P><G><P><C><H><P><G><H><S><F><R><L><L><D><S><S><P><C><A><E><S><G><D><A><L><Y><Y><R><V><V><R><A><H><E><D><A><W><H><I><L><V><A><K><V><P><K><P><G><A><D><V><P><H><P><W><G><L><E><L><Q><A><S><L><S><P><H><F><N><L><Q><G><L><C><G><L><V><P><E><G><T><L><P><G><A><P><W><R><G><A><V><A><L><A><A><E><V><P><E><R><T><V><A><Q><W><L><A><E><A><C><T><Q><P><P><E><E><F><V><W><A><V><A><L><L><L><L><Q><L><S><A><A><L><K><F><L><E><A><W><G><A><A><L><V><E><L><R><P><E><N><L><L><L><V><A><P><R><G><C><A><T><T><G><P><P><R><L><L><L><T><D><F><G><R><V><C><L><Q><P><P><G><P><P><G><S><P><G><P><H><A><P><Q><L><G><S><L><L><R><A><L><L><S><L><A><A><P><S><T><T><P><L><A><A><G><L><E><L><L><A><A><Q><L><T><R><L><R><P><S><A><S><R><T><R><G><A><L><Q><A><L><L><W><G><P><G><P><E><L><R><G><R><G><A><P><L><G><P><W><L><R><A><L><G><P><W><L><R><V><R><R><G><L><L><V><L><R><L><A><E><R><A><A><G><G><E><A><P><S><L><E><D><W><L><C><C><E><Y><L><A><E><A><T><E><S><S><M><G><Q><A><L><A><L><L><W><D>
Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellipodia-like extensions .<BOP>
Q6ZS72
P51993
FUT6_HUMAN
Galactoside 3-L-fucosyltransferase
Homo
<M><D><P><L><G><P><A><K><P><Q><W><S><W><R><C><C><L><T><T><L><L><F><Q><L><L><M><A><V><C><F><F><S><Y><L><R><V><S><Q><D><D><P><T><V><Y><P><N><G><S><R><F><P><D><S><T><G><T><P><A><H><S><I><P><L><I><L><L><W><T><W><P><F><N><K><P><I><A><L><P><R><C><S><E><M><V><P><G><T><A><D><C><N><I><T><A><D><R><K><V><Y><P><Q><A><D><A><V><I><V><H><H><R><E><V><M><Y><N><P><S><A><Q><L><P><R><S><P><R><R><Q><G><Q><R><W><I><W><F><S><M><E><S><P><S><H><C><W><Q><L><K><A><M><D><G><Y><F><N><L><T><M><S><Y><R><S><D><S><D><I><F><T><P><Y><G><W><L><E><P><W><S><G><Q><P><A><H><P><P><L><N><L><S><A><K><T><E><L><V><A><W><A><V><S><N><W><G><P><N><S><A><R><V><R><Y><Y><Q><S><L><Q><A><H><L><K><V><D><V><Y><G><R><S><H><K><P><L><P><Q><G><T><M><M><E><T><L><S><R><Y><K><F><Y><L><A><F><E><N><S><L><H><P><D><Y><I><T><E><K><L><W><R><N><A><L><E><A><W><A><V><P><V><V><L><G><P><S><R><S><N><Y><E><R><F><L><P><P><D><A><F><I><H><V><D><D><F><Q><S><P><K><D><L><A><R><Y><L><Q><E><L><D><K><D><H><A><R><Y><L><S><Y><F><R><W><R><E><T><L><R><P><R><S><F><S><W><A><L><A><F><C><K><A><C><W><K><L><Q><E><E><S><R><Y><Q><T><R><G><I><A><A><W><F><T>
Does not have alpha(1,3)-fucosyltransferase activity.<BOP>
P51993
Q6NZY4
ZCHC8_HUMAN
TRAMP-like complex RNA-binding factor ZCCHC8
Homo
<M><A><A><E><V><Y><F><G><D><L><E><L><F><E><P><F><D><H><P><E><E><S><I><P><K><P><V><H><T><R><F><K><D><D><D><G><D><E><E><D><E><N><G><V><G><D><A><E><L><R><E><R><L><R><Q><C><E><E><T><I><E><Q><L><R><A><E><N><Q><E><L><K><R><K><L><N><I><L><T><R><P><S><G><I><L><V><N><D><T><K><L><D><G><P><I><L><Q><I><L><F><M><N><N><A><I><S><K><Q><Y><H><Q><E><I><E><E><F><V><S><N><L><V><K><R><F><E><E><Q><Q><K><N><D><V><E><K><T><S><F><N><L><L><P><Q><P><S><S><I><V><L><E><E><D><H><K><V><E><E><S><C><A><I><K><N><N><K><E><A><F><S><V><V><G><S><V><L><Y><F><T><N><F><C><L><D><K><L><G><Q><P><L><L><N><E><N><P><Q><L><S><E><G><W><E><I><P><K><Y><H><Q><V><F><S><H><I><V><S><L><E><G><Q><E><I><Q><V><K><A><K><R><P><K><P><H><C><F><N><C><G><S><E><E><H><Q><M><K><D><C><P><M><P><R><N><A><A><R><I><S><E><K><R><K><E><Y><M><D><A><C><G><E><A><N><N><Q><N><F><Q><Q><R><Y><H><A><E><E><V><E><E><R><F><G><R><F><K><P><G><V><I><S><E><E><L><Q><D><A><L><G><V><T><D><K><S><L><P><P><F><I><Y><R><M><R><Q><L><G><Y><P><P><G><W><L><K><E><A><E><L><E><N><S><G><L><A><L><Y><D><G><K><D><G><T><D><G><E><T><E><V><G><E><I><Q><Q><N><K><S><V><T><Y><D><L><S><K><L><V><N><Y><P><G><F><N><I><S><T><P><R><G><I><P><D><E><W><R><I><F><G><S><I><P><M><Q><A><C><Q><Q><K><D><V><F><A><N><Y><L><T><S><N><F><Q><A><P><G><V><K><S><G><N><K><R><S><S><S><H><S><S><P><G><S><P><K><K><Q><K><N><E><S><N><S><A><G><S><P><A><D><M><E><L><D><S><D><M><E><V><P><H><G><S><Q><S><S><E><S><F><Q><F><Q><P><P><L><P><P><D><T><P><P><L><P><R><G><T><P><P><P><V><F><T><P><P><L><P><K><G><T><P><P><L><T><P><S><D><S><P><Q><T><R><T><A><S><G><A><V><D><E><D><A><L><T><L><E><E><L><E><E><Q><Q><R><R><I><W><A><A><L><E><Q><A><E><S><V><N><S><D><S><D><V><P><V><D><T><P><L><T><G><N><S><V><A><S><S><P><C><P><N><E><L><D><L><P><V><P><E><G><K><T><S><E><K><Q><T><L><D><E><P><E><V><P><E><I><F><T><K><K><S><E><A><G><H><A><S><S><P><D><S><E><V><T><S><L><C><Q><K><E><K><A><E><L><A><P><V><N><T><E><G><A><L><L><D><N><G><S><V><V><P><N><C><D><I><S><N><G><G><S><Q><K><L><F><P><A><D><T><S><P><S><T><A><T><K><I><H><S><P><I><P><D><M><S><K><F><A><T><G><I><T><P><F><E><F><E><N><M><A><E><S><T><G><M><Y><L><R><I><R><S><L><L><K><N><S><P><R><N><Q><Q><K><N><K><K><A><S><E>
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs . NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function .<BOP>
Q6NZY4
Q8NGL6
O4A15_HUMAN
Olfactory receptor OR11-118
Homo
<M><E><L><L><T><N><N><L><K><F><I><T><D><P><F><V><C><R><L><R><H><L><S><P><T><P><S><E><E><H><M><K><N><K><N><N><V><T><E><F><I><L><L><G><L><T><Q><N><P><E><G><Q><K><V><L><F><V><T><F><L><L><I><Y><M><V><T><I><M><G><N><L><L><I><I><V><T><I><M><A><S><Q><S><L><G><S><P><M><Y><F><F><L><A><S><L><S><F><I><D><T><V><Y><S><T><A><F><A><P><K><M><I><V><D><L><L><S><E><K><K><T><I><S><F><Q><G><C><M><A><Q><L><F><M><D><H><L><F><A><G><A><E><V><I><L><L><V><V><M><A><Y><D><R><Y><M><A><I><C><K><P><L><H><E><L><I><T><M><N><R><R><V><C><V><L><M><L><L><A><A><W><I><G><G><F><L><H><S><L><V><Q><F><L><F><I><Y><Q><L><P><F><C><G><P><N><V><I><D><N><F><L><C><D><L><Y><P><L><L><K><L><A><C><T><N><T><Y><V><T><G><L><S><M><I><A><N><G><G><A><I><C><A><V><T><F><F><T><I><L><L><S><Y><G><V><I><L><H><S><L><K><T><Q><S><L><E><G><K><R><K><A><F><Y><T><C><A><S><H><V><T><V><V><I><L><F><F><V><P><C><I><F><L><Y><A><R><P><N><S><T><F><P><I><D><K><S><M><T><V><V><L><T><F><I><T><P><M><L><N><P><L><I><Y><T><L><K><N><A><E><M><K><S><A><M><R><K><L><W><S><K><K><V><S><L><A><G><K><W><L><Y><H><S>
Odorant receptor.<BOP>
Q8NGL6