Datasets:
yangzhang33
/
Prot2Text-Diff-HUMAN-func256-seq768

Dataset card Data Studio Files
xet
Community
1
accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
⌀
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q969Q5
RAB24_HUMAN
Ras-related protein Rab-24
Homo
<M><S><G><Q><R><V><D><V><K><V><V><M><L><G><K><E><Y><V><G><K><T><S><L><V><E><R><Y><V><H><D><R><F><L><V><G><P><Y><Q><N><T><I><G><A><A><F><V><A><K><V><M><S><V><G><D><R><T><V><T><L><G><I><W><D><T><A><G><S><E><R><Y><E><A><M><S><R><I><Y><Y><R><G><A><K><A><A><I><V><C><Y><D><L><T><D><S><S><S><F><E><R><A><K><F><W><V><K><E><L><R><S><L><E><E><G><C><Q><I><Y><L><C><G><T><K><S><D><L><L><E><E><D><R><R><R><R><R><V><D><F><H><D><V><Q><D><Y><A><D><N><I><K><A><Q><L><F><E><T><S><S><K><T><G><Q><S><V><D><E><L><F><Q><K><V><A><E><D><Y><V><S><V><A><A><F><Q><V><M><T><E><D><K><G><V><D><L><G><Q><K><P><N><P><Y><F><Y><S><C><C><H><H>
May be involved in autophagy-related processes.<BOP>
Q969Q5
Q7RTZ2
U17L1_HUMAN
Ubiquitin-specific-processing protease 17-like protein 1
Homo
<M><G><D><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><S><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><E><N><A><S><L><Q><C><L><T><Y><T><L><P><L><A><N><Y><M><L><S><R><E><H><S><Q><T><C><Q><R><P><K><C><C><M><L><C><T><M><Q><A><H><I><T><W><A><L><H><S><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><V><H><E><F><L><M><F><T><V><D><A><M><K><K><A><C><L><P><G><H><K><Q><V><D><H><H><C><K><D><T><T><L><I><H><Q><I><F><G><G><C><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><K><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><L><C><L><Q><R><A><P><A><S><N><T><L><T><L><H><T><S><A><K><V><L><I><L><V><L><K><R><F><S><D><V><A><G><N><K><L><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><Q><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><D><G><H><Y><F><S><Y><V><K><A><Q><E><V><Q><W><Y><K><M><D><D><A><E><V><T><V><C><S><I><I><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><A><E><D><T><D><R><R><A><K><Q><G><E><L><K><R><D><H><P><C><L><Q><A><P><E><L><D><E><H><L><V><E><R><A><T><Q><E><S><T><L><D><H><W><K><F><L><Q><E><Q><N><K><T><K><P><E><F><N><V><G><K><V><E><G><T><L><P><P><N><A><L><V><I><H><Q><S><K><Y><K><C><G><M><K><N><H><H><P><E><Q><Q><S><S><L><L><N><L><S><S><T><T><R><T><D><Q><E><S><M><N><T><G><T><L><A><S><L><Q><G><R><T><R><R><A><K><G><K><N><K><H><S><K><R><A><L><L><V><C><Q>
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP>
Q7RTZ2
Q3KNS6
ZN829_HUMAN
Zinc finger protein 829
Homo
<M><P><H><S><P><L><I><S><I><P><H><V><W><C><H><P><E><E><E><E><R><M><H><D><E><L><L><Q><A><V><S><K><G><P><V><M><F><R><D><V><S><I><D><F><S><Q><E><E><W><E><C><L><D><A><D><Q><M><N><L><Y><K><E><V><M><L><E><N><F><S><N><L><V><S><V><G><L><S><N><S><K><P><A><V><I><S><L><L><E><Q><G><K><E><P><W><M><V><D><R><E><L><T><R><G><L><C><S><D><L><E><S><M><C><E><T><K><I><L><S><L><K><K><R><H><F><S><Q><V><I><I><T><R><E><D><M><S><T><F><I><Q><P><T><F><L><I><P><P><Q><K><T><M><S><E><E><K><P><W><E><C><K><I><C><G><K><T><F><N><Q><N><S><Q><F><I><Q><H><Q><R><I><H><F><G><E><K><H><Y><E><S><K><E><Y><G><K><S><F><S><R><G><S><L><V><T><R><H><Q><R><I><H><T><G><K><K><P><Y><E><C><K><E><C><G><K><A><F><S><C><S><S><Y><F><S><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><K><Y><C><S><N><L><N><D><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><V><C><G><K><A><F><T><K><S><S><Q><L><F><L><H><L><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><T><Q><H><S><R><L><I><Q><H><Q><R><M><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><N><S><A><S><T><L><T><N><H><H><R><I><H><A><G><E><K><L><Y><E><C><E><E><C><R><K><A><F><I><Q><S><S><E><L><I><Q><H><Q><R><I><H><T><D><E><K><P><Y><E><C><N><E><C><G><K><A><F><N><K><G><S><N><L><T><R><H><Q><R><I><H><T><G><E><K><P><Y><D><C><K><E><C><G><K><A><F><G><S><R><S><D><L><I><R><H><E><G><I><H><T><G>
May be involved in transcriptional regulation.<BOP>
Q3KNS6
Q13586
STIM1_HUMAN
Stromal interaction molecule 1
Homo
<M><D><V><C><V><R><L><A><L><W><L><L><W><G><L><L><L><H><Q><G><Q><S><L><S><H><S><H><S><E><K><A><T><G><T><S><S><G><A><N><S><E><E><S><T><A><A><E><F><C><R><I><D><K><P><L><C><H><S><E><D><E><K><L><S><F><E><A><V><R><N><I><H><K><L><M><D><D><D><A><N><G><D><V><D><V><E><E><S><D><E><F><L><R><E><D><L><N><Y><H><D><P><T><V><K><H><S><T><F><H><G><E><D><K><L><I><S><V><E><D><L><W><K><A><W><K><S><S><E><V><Y><N><W><T><V><D><E><V><V><Q><W><L><I><T><Y><V><E><L><P><Q><Y><E><E><T><F><R><K><L><Q><L><S><G><H><A><M><P><R><L><A><V><T><N><T><T><M><T><G><T><V><L><K><M><T><D><R><S><H><R><Q><K><L><Q><L><K><A><L><D><T><V><L><F><G><P><P><L><L><T><R><H><N><H><L><K><D><F><M><L><V><V><S><I><V><I><G><V><G><G><C><W><F><A><Y><I><Q><N><R><Y><S><K><E><H><M><K><K><M><M><K><D><L><E><G><L><H><R><A><E><Q><S><L><H><D><L><Q><E><R><L><H><K><A><Q><E><E><H><R><T><V><E><V><E><K><V><H><L><E><K><K><L><R><D><E><I><N><L><A><K><Q><E><A><Q><R><L><K><E><L><R><E><G><T><E><N><E><R><S><R><Q><K><Y><A><E><E><E><L><E><Q><V><R><E><A><L><R><K><A><E><K><E><L><E><S><H><S><S><W><Y><A><P><E><A><L><Q><K><W><L><Q><L><T><H><E><V><E><V><Q><Y><Y><N><I><K><K><Q><N><A><E><K><Q><L><L><V><A><K><E><G><A><E><K><I><K><K><K><R><N><T><L><F><G><T><F><H><V><A><H><S><S><S><L><D><D><V><D><H><K><I><L><T><A><K><Q><A><L><S><E><V><T><A><A><L><R><E><R><L><H><R><W><Q><Q><I><E><I><L><C><G><F><Q><I><V><N><N><P><G><I><H><S><L><V><A><A><L><N><I><D><P><S><W><M><G><S><T><R><P><N><P><A><H><F><I><M><T><D><D><V><D><D><M><D><E><E><I><V><S><P><L><S><M><Q><S><P><S><L><Q><S><S><V><R><Q><R><L><T><E><P><Q><H><G><L><G><S><Q><R><D><L><T><H><S><D><S><E><S><S><L><H><M><S><D><R><Q><R><V><A><P><K><P><P><Q><M><S><R><A><A><D><E><A><L><N><A><M><T><S><N><G><S><H><R><L><I><E><G><V><H><P><G><S><L><V><E><K><L><P><D><S><P><A><L><A><K><K><A><L><L><A><L><N><H><G><L><D><K><A><H><S><L><M><E><L><S><P><S><A><P><P><G><G><S><P><H><L><D><S><S><R><S><H><S><P><S><S><P><D><P><D><T><P><S><P><V><G><D><S><R><A><L><Q><A><S><R><N><T><R><I><P><H><L><A><G><K><K><A><V><A><E><E><D><N><G><S><I><G><E><E><T><D><S><S><P><G><R><K><K><F><P><L><K><I><F><K><K><P><L><K><K>
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores . Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 . Involved in enamel formation . Activated following interaction with STIMATE, leading to promote STIM1 conformational switch .<BOP>
Q13586
P51648
AL3A2_HUMAN
Microsomal aldehyde dehydrogenase
Homo
<M><E><L><E><V><R><R><V><R><Q><A><F><L><S><G><R><S><R><P><L><R><F><R><L><Q><Q><L><E><A><L><R><R><M><V><Q><E><R><E><K><D><I><L><T><A><I><A><A><D><L><C><K><S><E><F><N><V><Y><S><Q><E><V><I><T><V><L><G><E><I><D><F><M><L><E><N><L><P><E><W><V><T><A><K><P><V><K><K><N><V><L><T><M><L><D><E><A><Y><I><Q><P><Q><P><L><G><V><V><L><I><I><G><A><W><N><Y><P><F><V><L><T><I><Q><P><L><I><G><A><I><A><A><G><N><A><V><I><I><K><P><S><E><L><S><E><N><T><A><K><I><L><A><K><L><L><P><Q><Y><L><D><Q><D><L><Y><I><V><I><N><G><G><V><E><E><T><T><E><L><L><K><Q><R><F><D><H><I><F><Y><T><G><N><T><A><V><G><K><I><V><M><E><A><A><A><K><H><L><T><P><V><T><L><E><L><G><G><K><S><P><C><Y><I><D><K><D><C><D><L><D><I><V><C><R><R><I><T><W><G><K><Y><M><N><C><G><Q><T><C><I><A><P><D><Y><I><L><C><E><A><S><L><Q><N><Q><I><V><W><K><I><K><E><T><V><K><E><F><Y><G><E><N><I><K><E><S><P><D><Y><E><R><I><I><N><L><R><H><F><K><R><I><L><S><L><L><E><G><Q><K><I><A><F><G><G><E><T><D><E><A><T><R><Y><I><A><P><T><V><L><T><D><V><D><P><K><T><K><V><M><Q><E><E><I><F><G><P><I><L><P><I><V><P><V><K><N><V><D><E><A><I><N><F><I><N><E><R><E><K><P><L><A><L><Y><V><F><S><H><N><H><K><L><I><K><R><M><I><D><E><T><S><S><G><G><V><T><G><N><D><V><I><M><H><F><T><L><N><S><F><P><F><G><G><V><G><S><S><G><M><G><A><Y><H><G><K><H><S><F><D><T><F><S><H><Q><R><P><C><L><L><K><S><L><K><R><E><G><A><N><K><L><R><Y><P><P><N><S><Q><S><K><V><D><W><G><K><F><F><L><L><K><R><F><N><K><E><K><L><G><L><L><L><L><T><F><L><G><I><V><A><A><V><L><V><K><A><E><Y><Y>
Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length . Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid .<BOP>
P51648
Q8TBE1
CNIH3_HUMAN
Cornichon family AMPA receptor auxiliary protein 3
Homo
<M><A><F><T><F><A><A><F><C><Y><M><L><S><L><V><L><C><A><A><L><I><F><F><A><I><W><H><I><I><A><F><D><E><L><R><T><D><F><K><S><P><I><D><Q><C><N><P><V><H><A><R><E><R><L><R><N><I><E><R><I><C><F><L><L><R><K><L><V><L><P><E><Y><S><I><H><S><L><F><C><I><M><F><L><C><A><Q><E><W><L><T><L><G><L><N><V><P><L><L><F><Y><H><F><W><R><Y><F><H><C><P><A><D><S><S><E><L><A><Y><D><P><P><V><V><M><N><A><D><T><L><S><Y><C><Q><K><E><A><W><C><K><L><A><F><Y><L><L><S><F><F><Y><Y><L><Y><C><M><I><Y><T><L><V><S><S>
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.<BOP>
Q8TBE1
P26842
CD27_HUMAN
Tumor necrosis factor receptor superfamily member 7
Homo
<M><A><R><P><H><P><W><W><L><C><V><L><G><T><L><V><G><L><S><A><T><P><A><P><K><S><C><P><E><R><H><Y><W><A><Q><G><K><L><C><C><Q><M><C><E><P><G><T><F><L><V><K><D><C><D><Q><H><R><K><A><A><Q><C><D><P><C><I><P><G><V><S><F><S><P><D><H><H><T><R><P><H><C><E><S><C><R><H><C><N><S><G><L><L><V><R><N><C><T><I><T><A><N><A><E><C><A><C><R><N><G><W><Q><C><R><D><K><E><C><T><E><C><D><P><L><P><N><P><S><L><T><A><R><S><S><Q><A><L><S><P><H><P><Q><P><T><H><L><P><Y><V><S><E><M><L><E><A><R><T><A><G><H><M><Q><T><L><A><D><F><R><Q><L><P><A><R><T><L><S><T><H><W><P><P><Q><R><S><L><C><S><S><D><F><I><R><I><L><V><I><F><S><G><M><F><L><V><F><T><L><A><G><A><L><F><L><H><Q><R><R><K><Y><R><S><N><K><G><E><S><P><V><E><P><A><E><P><C><H><Y><S><C><P><R><E><E><E><G><S><T><I><P><I><Q><E><D><Y><R><K><P><E><P><A><C><S><P>
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.<BOP>
P26842
Q92542
NICA_HUMAN
Nicastrin
Homo
<M><A><T><A><G><G><G><S><G><A><D><P><G><S><R><G><L><L><R><L><L><S><F><C><V><L><L><A><G><L><C><R><G><N><S><V><E><R><K><I><Y><I><P><L><N><K><T><A><P><C><V><R><L><L><N><A><T><H><Q><I><G><C><Q><S><S><I><S><G><D><T><G><V><I><H><V><V><E><K><E><E><D><L><Q><W><V><L><T><D><G><P><N><P><P><Y><M><V><L><L><E><S><K><H><F><T><R><D><L><M><E><K><L><K><G><R><T><S><R><I><A><G><L><A><V><S><L><T><K><P><S><P><A><S><G><F><S><P><S><V><Q><C><P><N><D><G><F><G><V><Y><S><N><S><Y><G><P><E><F><A><H><C><R><E><I><Q><W><N><S><L><G><N><G><L><A><Y><E><D><F><S><F><P><I><F><L><L><E><D><E><N><E><T><K><V><I><K><Q><C><Y><Q><D><H><N><L><S><Q><N><G><S><A><P><T><F><P><L><C><A><M><Q><L><F><S><H><M><H><A><V><I><S><T><A><T><C><M><R><R><S><S><I><Q><S><T><F><S><I><N><P><E><I><V><C><D><P><L><S><D><Y><N><V><W><S><M><L><K><P><I><N><T><T><G><T><L><K><P><D><D><R><V><V><V><A><A><T><R><L><D><S><R><S><F><F><W><N><V><A><P><G><A><E><S><A><V><A><S><F><V><T><Q><L><A><A><A><E><A><L><Q><K><A><P><D><V><T><T><L><P><R><N><V><M><F><V><F><F><Q><G><E><T><F><D><Y><I><G><S><S><R><M><V><Y><D><M><E><K><G><K><F><P><V><Q><L><E><N><V><D><S><F><V><E><L><G><Q><V><A><L><R><T><S><L><E><L><W><M><H><T><D><P><V><S><Q><K><N><E><S><V><R><N><Q><V><E><D><L><L><A><T><L><E><K><S><G><A><G><V><P><A><V><I><L><R><R><P><N><Q><S><Q><P><L><P><P><S><S><L><Q><R><F><L><R><A><R><N><I><S><G><V><V><L><A><D><H><S><G><A><F><H><N><K><Y><Y><Q><S><I><Y><D><T><A><E><N><I><N><V><S><Y><P><E><W><L><S><P><E><E><D><L><N><F><V><T><D><T><A><K><A><L><A><D><V><A><T><V><L><G><R><A><L><Y><E><L><A><G><G><T><N><F><S><D><T><V><Q><A><D><P><Q><T><V><T><R><L><L><Y><G><F><L><I><K><A><N><N><S><W><F><Q><S><I><L><R><Q><D><L><R><S><Y><L><G><D><G><P><L><Q><H><Y><I><A><V><S><S><P><T><N><T><T><Y><V><V><Q><Y><A><L><A><N><L><T><G><T><V><V><N><L><T><R><E><Q><C><Q><D><P><S><K><V><P><S><E><N><K><D><L><Y><E><Y><S><W><V><Q><G><P><L><H><S><N><E><T><D><R><L><P><R><C><V><R><S><T><A><R><L><A><R><A><L><S><P><A><F><E><L><S><Q><W><S><S><T><E><Y><S><T><W><T><E><S><R><W><K><D><I><R><A><R><I><F><L><I><A><S><K><E><L><E><L><I><T><L><T><V><G><F><G><I><L><I><F><S><L><I><V><T><Y><C><I><N><A><K><A><D><V><L><F><I><A><P><R><E><P><G><A><V><S><Y>
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.<BOP>
Q92542
Q86YP4
P66A_HUMAN
GATA zinc finger domain-containing protein 2A
Homo
<M><T><E><E><A><C><R><T><R><S><Q><K><R><A><L><E><R><D><P><T><E><D><D><V><E><S><K><K><I><K><M><E><R><G><L><L><A><S><D><L><N><T><D><G><D><M><R><V><T><P><E><P><G><A><G><P><T><Q><G><L><L><R><A><T><E><A><T><A><M><A><M><G><R><G><E><G><L><V><G><D><G><P><V><D><M><R><T><S><H><S><D><M><K><S><E><R><R><P><P><S><P><D><V><I><V><L><S><D><N><E><Q><P><S><S><P><R><V><N><G><L><T><T><V><A><L><K><E><T><S><T><E><A><L><M><K><S><S><P><E><E><R><E><R><M><I><K><Q><L><K><E><E><L><R><L><E><E><A><K><L><V><L><L><K><K><L><R><Q><S><Q><I><Q><K><E><A><T><A><Q><K><P><T><G><S><V><G><S><T><V><T><T><P><P><P><L><V><R><G><T><Q><N><I><P><A><G><K><P><S><L><Q><T><S><S><A><R><M><P><G><S><V><I><P><P><P><L><V><R><G><G><Q><Q><A><S><S><K><L><G><P><Q><A><S><S><Q><V><V><M><P><P><L><V><R><G><A><Q><Q><I><H><S><I><R><Q><H><S><S><T><G><P><P><P><L><L><L><A><P><R><A><S><V><P><S><V><Q><I><Q><G><Q><R><I><I><Q><Q><G><L><I><R><V><A><N><V><P><N><T><S><L><L><V><N><I><P><Q><P><T><P><A><S><L><K><G><T><T><A><T><S><A><Q><A><N><S><T><P><T><S><V><A><S><V><V><T><S><A><E><S><P><A><S><R><Q><A><A><A><K><L><A><L><R><K><Q><L><E><K><T><L><L><E><I><P><P><P><K><P><P><A><P><E><M><N><F><L><P><S><A><A><N><N><E><F><I><Y><L><V><G><L><E><E><V><V><Q><N><L><L><E><T><Q><G><R><M><S><A><A><T><V><L><S><R><E><P><Y><M><C><A><Q><C><K><T><D><F><T><C><R><W><R><E><E><K><S><G><A><I><M><C><E><N><C><M><T><T><N><Q><K><K><A><L><K><V><E><H><T><S><R><L><K><A><A><F><V><K><A><L><Q><Q><E><Q><E><I><E><Q><R><L><L><Q><Q><G><T><A><P><A><Q><A><K><A><E><P><T><A><A><P><H><P><V><L><K><Q><V><I><K><P><R><R><K><L><A><F><R><S><G><E><A><R><D><W><S><N><G><A><V><L><Q><A><S><S><Q><L><S><R><G><S><A><T><T><P><R><G><V><L><H><T><F><S><P><S><P><K><L><Q><N><S><A><S><A><T><A><L><V><S><R><T><G><R><H><S><E><R><T><V><S><A><G><K><G><S><A><T><S><N><W><K><K><T><P><L><S><T><G><G><T><L><A><F><V><S><P><S><L><A><V><H><K><S><S><S><A><V><D><R><Q><R><E><Y><L><L><D><M><I><P><P><R><S><I><P><Q><S><A><T><W><K>
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.<BOP>
Q86YP4
Q5SWX8
ODR4_HUMAN
Transactivated by transforming growth factor beta protein 1
Homo
<M><G><R><T><Y><I><V><E><E><T><V><G><Q><Y><L><S><N><I><N><L><Q><G><K><A><F><V><S><G><L><L><I><G><Q><C><S><S><Q><K><D><Y><V><I><L><A><T><R><T><P><P><K><E><E><Q><S><E><N><L><K><H><P><K><A><K><L><D><N><L><D><E><E><W><A><T><E><H><A><C><Q><V><S><R><M><L><P><G><G><L><L><V><L><G><V><F><I><I><T><T><L><E><L><A><N><D><F><Q><N><A><L><R><R><L><M><F><A><V><E><K><S><I><N><R><K><R><L><W><N><F><T><E><E><E><V><S><E><R><V><T><L><H><I><C><A><S><T><K><K><I><F><C><R><T><Y><D><I><H><D><P><K><S><S><A><R><P><A><D><W><K><Y><Q><S><G><L><S><S><S><W><L><S><L><E><C><T><V><H><I><N><I><H><I><P><L><S><A><T><S><V><S><Y><T><L><E><K><N><T><K><N><G><L><T><R><W><A><K><E><I><E><N><G><V><Y><L><I><N><G><Q><V><K><D><E><D><C><D><L><L><E><G><Q><K><K><S><S><R><G><N><T><Q><A><T><S><H><S><F><D><V><R><V><L><T><Q><L><L><L><N><S><D><H><R><S><T><A><T><V><Q><I><C><S><G><S><V><N><L><K><G><A><V><K><C><R><A><Y><I><H><S><S><K><P><K><V><K><D><A><V><Q><A><V><K><R><D><I><L><N><T><V><A><D><R><C><E><M><L><F><E><D><L><L><L><N><E><I><P><E><K><K><D><S><E><K><E><F><H><V><L><P><Y><R><V><F><V><P><L><P><G><S><T><V><M><L><C><D><Y><K><F><D><D><E><S><A><E><E><I><R><D><H><F><M><E><M><L><D><H><T><I><Q><I><E><D><L><E><I><A><E><E><T><N><T><A><C><M><S><S><S><M><N><S><Q><A><S><L><D><N><T><D><D><E><Q><P><K><Q><P><I><K><T><T><M><L><L><K><I><Q><Q><N><I><G><V><I><A><A><F><T><V><A><V><L><A><A><G><I><S><F><H><Y><F><S><D>
May play a role in the trafficking of a subset of G-protein coupled receptors.<BOP>
Q5SWX8
Q96PX1
RN157_HUMAN
RING-type E3 ubiquitin transferase RNF157
Homo
<M><G><A><L><T><S><R><Q><H><A><G><V><E><E><V><D><I><P><S><N><S><V><Y><R><Y><P><P><K><S><G><S><Y><F><A><S><H><F><I><M><G><G><E><K><F><D><S><T><H><P><E><G><Y><L><F><G><E><N><S><D><L><N><F><L><G><N><R><P><V><V><F><P><Y><A><A><P><P><P><Q><E><P><V><K><T><L><R><S><L><V><N><I><R><K><D><T><L><R><L><V><K><C><A><E><E><V><K><S><P><G><E><E><A><S><K><A><K><V><H><Y><N><V><E><F><T><F><D><T><D><A><R><V><A><I><T><I><Y><Y><Q><A><T><E><E><F><Q><N><G><I><A><S><Y><I><P><K><D><N><S><L><Q><S><E><T><V><Q><Y><K><R><G><V><C><Q><Q><F><C><L><P><S><H><T><V><D><P><S><E><W><A><E><E><E><L><G><F><D><L><D><R><E><V><Y><P><L><V><V><H><A><V><V><D><E><G><D><E><Y><F><G><H><C><H><V><L><L><G><T><F><E><K><H><T><D><G><T><F><C><V><K><P><L><K><Q><K><Q><V><V><D><G><V><S><Y><L><L><Q><E><I><Y><G><I><E><N><K><Y><N><T><Q><D><S><K><V><A><E><D><E><V><S><D><N><S><A><E><C><V><V><C><L><S><D><V><R><D><T><L><I><L><P><C><R><H><L><C><L><C><N><T><C><A><D><T><L><R><Y><Q><A><N><N><C><P><I><C><R><L><P><F><R><A><L><L><Q><I><R><A><M><R><K><K><L><G><P><L><S><P><T><S><F><N><P><I><I><S><S><Q><T><S><D><S><E><E><H><P><S><S><E><N><I><P><P><G><Y><E><V><V><S><L><L><E><A><L><N><G><P><L><T><P><S><P><A><V><P><P><L><H><V><L><G><D><G><H><L><S><G><M><L><P><S><Y><G><S><D><G><H><L><P><P><V><R><T><I><S><P><L><D><R><L><S><D><S><S><S><Q><G><L><K><L><K><K><S><L><S><K><S><T><S><Q><N><S><S><V><L><H><E><E><E><D><E><H><S><C><S><E><S><E><T><Q><L><S><Q><R><P><S><V><Q><H><L><G><E><E><C><G><V><T><P><E><S><E><N><L><T><L><S><S><S><G><A><I><D><Q><S><S><C><T><G><T><P><L><S><S><T><I><S><S><P><E><G><P><A><S><S><S><L><A><Q><S><V><M><S><M><A><S><S><Q><I><S><T><D><T><V><S><S><M><S><G><S><Y><I><A><P><G><T><E><E><E><G><E><A><L><S><S><P><Q><P><A><S><R><A><P><S><E><E><G><E><G><L><P><A><E><S><P><D><S><N><F><A><G><L><P><A><G><E><Q><D><A><E><G><N><D><V><I><E><E><E><D><G><S><P><T><Q><E><G><Q><R><T><C><A><F><L><G><M><E><C><D><N><N><N><D><F><D><I><A><S><V><K><A><L><D><N><K><L><C><S><E><V><C><L><P><G><A><W><Q><A><D><D><N><A><V><S><R><N><A><Q><R><R><R><L><S><S><S><S><L><E><D><S><E><T><R><P><C><V><W><G><P><L><A><V>
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons . Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical . May act as a scaffold molecule to regulate this process . Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle .<BOP>
Q96PX1
Q9Y2L9
LRCH1_HUMAN
Neuronal protein 81
Homo
<M><A><T><P><G><S><E><P><Q><P><F><V><P><A><L><S><V><A><T><L><H><P><L><H><H><P><H><H><H><H><H><H><H><Q><H><H><G><G><T><G><A><P><G><G><A><G><G><G><G><G><G><S><G><G><F><N><L><P><L><N><R><G><L><E><R><A><L><E><E><A><A><N><S><G><G><L><N><L><S><A><R><K><L><K><E><F><P><R><T><A><A><P><G><H><D><L><S><D><T><V><Q><A><D><L><S><K><N><R><L><V><E><V><P><M><E><L><C><H><F><V><S><L><E><I><L><N><L><Y><H><N><C><I><R><V><I><P><E><A><I><V><N><L><Q><M><L><T><Y><L><N><L><S><R><N><Q><L><S><A><L><P><A><C><L><C><G><L><P><L><K><V><L><I><A><S><N><N><K><L><G><S><L><P><E><E><I><G><Q><L><K><Q><L><M><E><L><D><V><S><C><N><E><I><T><A><L><P><Q><Q><I><G><Q><L><K><S><L><R><E><L><N><V><R><R><N><Y><L><K><V><L><P><Q><E><L><V><D><L><S><L><V><K><F><D><F><S><C><N><K><V><L><V><I><P><I><C><F><R><E><M><K><Q><L><Q><V><L><L><L><E><N><N><P><L><Q><S><P><P><A><Q><I><C><T><K><G><K><V><H><I><F><K><Y><L><S><I><Q><A><C><Q><I><K><T><A><D><S><L><Y><L><H><T><M><E><R><P><H><L><H><Q><H><V><E><D><G><K><K><D><S><D><S><G><V><G><S><D><N><G><D><K><R><L><S><A><T><E><P><S><D><E><D><T><V><S><L><N><V><P><M><S><N><I><M><E><E><E><Q><I><I><K><E><D><S><C><H><R><L><S><P><V><K><G><E><F><H><Q><E><F><Q><P><E><P><S><L><L><G><D><S><T><N><S><G><E><E><R><D><Q><F><T><D><R><A><D><G><L><H><S><E><F><M><N><Y><K><A><R><A><E><D><C><E><E><L><L><R><I><E><E><D><V><H><W><Q><T><E><G><I><I><S><S><S><K><D><Q><D><M><D><I><A><M><I><E><Q><L><R><E><A><V><D><L><L><Q><D><P><N><G><L><S><T><D><I><T><E><R><S><V><L><N><L><Y><P><M><G><S><A><E><A><L><E><L><Q><D><S><A><L><N><G><Q><I><Q><L><E><T><S><P><V><C><E><V><Q><S><D><L><T><L><Q><S><N><G><S><Q><Y><S><P><N><E><I><R><E><N><S><P><A><V><S><P><T><T><N><S><T><A><P><F><G><L><K><P><R><S><V><F><L><R><P><Q><R><N><L><E><S><I><D><P><Q><F><T><I><R><R><K><M><E><Q><M><R><E><E><K><E><L><V><E><Q><L><R><E><S><I><E><M><R><L><K><V><S><L><H><E><D><L><G><A><A><L><M><D><G><V><V><L><C><H><L><V><N><H><I><R><P><R><S><V><A><S><I><H><V><P><S><P><A><V><P><K><L><S><M><A><K><C><R><R><N><V><E><N><F><L><E><A><C><R><K><L><G><V><P><E><A><D><L><C><S><P><C><D><I><L><Q><L><D><F><R><H><I><R><K><T><V><D><T><L><L><A><L><G><E><K><A><P><P><P><T><S><A><L><R><S><R><D><L><I><G><F><C><L><V><H><I><L><F><I><V><L><V><Y><I><T><Y><H><W><N><A><L><S><A>
Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.<BOP>
Q9Y2L9
Q8NGV6
OR5H6_HUMAN
Olfactory receptor OR3-11
Homo
<M><F><L><Y><L><C><F><I><F><Q><R><T><C><S><E><E><M><E><E><E><N><A><T><L><L><T><E><F><V><L><T><G><F><L><H><Q><P><D><C><K><I><P><L><F><L><A><F><L><V><I><Y><L><I><T><I><M><G><N><L><G><L><I><V><L><I><W><K><D><P><H><L><H><I><P><M><Y><L><F><L><G><S><L><A><F><V><D><A><S><L><S><S><T><V><T><P><K><M><L><I><N><F><L><A><K><S><K><M><I><S><L><S><E><C><M><V><Q><F><F><S><L><V><T><T><V><T><T><E><C><F><L><L><A><T><M><A><Y><D><R><Y><V><A><I><C><K><A><L><L><Y><P><V><I><M><T><N><E><L><C><I><Q><L><L><V><L><S><F><I><G><G><L><L><H><A><L><I><H><E><A><F><S><F><R><L><T><F><C><N><S><N><I><I><Q><H><F><Y><C><D><I><I><P><L><L><K><I><S><C><T><D><S><S><I><N><F><L><M><V><F><I><F><A><G><S><V><Q><V><F><T><I><G><T><I><L><I><S><Y><T><I><I><L><F><T><I><L><E><K><K><S><I><K><G><I><R><K><A><V><S><T><C><G><A><H><L><L><S><V><S><L><Y><Y><G><P><L><T><F><K><Y><L><G><S><A><S><P><Q><A><D><D><Q><D><M><M><E><S><L><F><Y><T><V><I><V><P><L><L><N><P><M><I><Y><S><L><R><N><K><Q><V><I><A><S><F><T><K><M><F><K><S><N><V>
Odorant receptor.<BOP>
Q8NGV6
P47929
LEG7_HUMAN
p53-induced gene 1 protein
Homo
<M><S><N><V><P><H><K><S><S><L><P><E><G><I><R><P><G><T><V><L><R><I><R><G><L><V><P><P><N><A><S><R><F><H><V><N><L><L><C><G><E><E><Q><G><S><D><A><A><L><H><F><N><P><R><L><D><T><S><E><V><V><F><N><S><K><E><Q><G><S><W><G><R><E><E><R><G><P><G><V><P><F><Q><R><G><Q><P><F><E><V><L><I><I><A><S><D><D><G><F><K><A><V><V><G><D><A><Q><Y><H><H><F><R><H><R><L><P><L><A><R><V><R><L><V><E><V><G><G><D><V><Q><L><D><S><V><R><I><F>
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.<BOP>
P47929
Q13835
PKP1_HUMAN
Band 6 protein
Homo
<M><N><H><S><P><L><K><T><A><L><A><Y><E><C><F><Q><D><Q><D><N><S><T><L><A><L><P><S><D><Q><K><M><K><T><G><T><S><G><R><Q><R><V><Q><E><Q><V><M><M><T><V><K><R><Q><K><S><K><S><S><Q><S><S><T><L><S><H><S><N><R><G><S><M><Y><D><G><L><A><D><N><Y><N><Y><G><T><T><S><R><S><S><Y><Y><S><K><F><Q><A><G><N><G><S><W><G><Y><P><I><Y><N><G><T><L><K><R><E><P><D><N><R><R><F><S><S><Y><S><Q><M><E><N><W><S><R><H><Y><P><R><G><S><C><N><T><T><G><A><G><S><D><I><C><F><M><Q><K><I><K><A><S><R><S><E><P><D><L><Y><C><D><P><R><G><T><L><R><K><G><T><L><G><S><K><G><Q><K><T><T><Q><N><R><Y><S><F><Y><S><T><C><S><G><Q><K><A><I><K><K><C><P><V><R><P><P><S><C><A><S><K><Q><D><P><V><Y><I><P><P><I><S><C><N><K><D><L><S><F><G><H><S><R><A><S><S><K><I><C><S><E><D><I><E><C><S><G><L><T><I><P><K><A><V><Q><Y><L><S><S><Q><D><E><K><Y><Q><A><I><G><A><Y><Y><I><Q><H><T><C><F><Q><D><E><S><A><K><Q><Q><V><Y><Q><L><G><G><I><C><K><L><V><D><L><L><R><S><P><N><Q><N><V><Q><Q><A><A><A><G><A><L><R><N><L><V><F><R><S><T><T><N><K><L><E><T><R><R><Q><N><G><I><R><E><A><V><S><L><L><R><R><T><G><N><A><E><I><Q><K><Q><L><T><G><L><L><W><N><L><S><S><T><D><E><L><K><E><E><L><I><A><D><A><L><P><V><L><A><D><R><V><I><I><P><F><S><G><W><C><D><G><N><S><N><M><S><R><E><V><V><D><P><E><V><F><F><N><A><T><G><C><L><R><K><R><L><G><M><R><E><L><L><A><L><V><P><Q><R><A><T><S><S><R><V><N><L><S><S><A><D><A><G><R><Q><T><M><R><N><Y><S><G><L><I><D><S><L><M><A><Y><V><Q><N><C><V><A><A><S><R><C><D><D><K><S><V><E><N><C><M><C><V><L><H><N><L><S><Y><R><L><D><A><E><V><P><T><R><Y><R><Q><L><E><Y><N><A><R><N><A><Y><T><E><K><S><S><T><G><C><F><S><N><K><S><D><K><M><M><N><N><N><Y><D><C><P><L><P><E><E><E><T><N><P><K><G><S><G><W><L><Y><H><S><D><A><I><R><T><Y><L><N><L><M><G><K><S><K><K><D><A><T><L><E><A><C><A><G><A><L><Q><N><L><T><A><S><K><G><L><M><S><S><G><M><S><Q><L><I><G><L><K><E><K><G><L><P><Q><I><A><R><L><L><Q><S><G><N><S><D><V><V><R><S><G><A><S><L><L><S><N><M><S><R><H><P><L><L><H><R><V><M><G><N><Q><V><F><P><E><V><T><R><L><L><T><S><H><T><G><N><T><S><N><S><E><D><I><L><S><S><A><C><Y><T><V><R><N><L><M><A><S><Q><P><Q><L><A><K><Q><Y><F><S><S><S><M><L><N><N><I><I><N><L><C><R><S><S><A><S><P><K><A><A><E><A><A><R><L><L><L><S><D><M><W><S><S><K><E><L><Q><G><V><L><R><Q><Q><G><F><D><R><N><M><L><G><T><L><A><G><A><N><S><L><R><N><F><T><S><R><F>
Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis . May facilitate the formation of intermediate filaments .<BOP>
Q13835
P25311
ZA2G_HUMAN
Zinc-alpha-2-glycoprotein
Homo
<M><V><R><M><V><P><V><L><L><S><L><L><L><L><L><G><P><A><V><P><Q><E><N><Q><D><G><R><Y><S><L><T><Y><I><Y><T><G><L><S><K><H><V><E><D><V><P><A><F><Q><A><L><G><S><L><N><D><L><Q><F><F><R><Y><N><S><K><D><R><K><S><Q><P><M><G><L><W><R><Q><V><E><G><M><E><D><W><K><Q><D><S><Q><L><Q><K><A><R><E><D><I><F><M><E><T><L><K><D><I><V><E><Y><Y><N><D><S><N><G><S><H><V><L><Q><G><R><F><G><C><E><I><E><N><N><R><S><S><G><A><F><W><K><Y><Y><Y><D><G><K><D><Y><I><E><F><N><K><E><I><P><A><W><V><P><F><D><P><A><A><Q><I><T><K><Q><K><W><E><A><E><P><V><Y><V><Q><R><A><K><A><Y><L><E><E><E><C><P><A><T><L><R><K><Y><L><K><Y><S><K><N><I><L><D><R><Q><D><P><P><S><V><V><V><T><S><H><Q><A><P><G><E><K><K><K><L><K><C><L><A><Y><D><F><Y><P><G><K><I><D><V><H><W><T><R><A><G><E><V><Q><E><P><E><L><R><G><D><V><L><H><N><G><N><G><T><Y><Q><S><W><V><V><V><A><V><P><P><Q><D><T><A><P><Y><S><C><H><V><Q><H><S><S><L><A><Q><P><L><V><V><P><W><E><A><S>
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.<BOP>
P25311
Q99741
CDC6_HUMAN
p62(cdc6)
Homo
<M><P><Q><T><R><S><Q><A><Q><A><T><I><S><F><P><K><R><K><L><S><R><A><L><N><K><A><K><N><S><S><D><A><K><L><E><P><T><N><V><Q><T><V><T><C><S><P><R><V><K><A><L><P><L><S><P><R><K><R><L><G><D><D><N><L><C><N><T><P><H><L><P><P><C><S><P><P><K><Q><G><K><K><E><N><G><P><P><H><S><H><T><L><K><G><R><R><L><V><F><D><N><Q><L><T><I><K><S><P><S><K><R><E><L><A><K><V><H><Q><N><K><I><L><S><S><V><R><K><S><Q><E><I><T><T><N><S><E><Q><R><C><P><L><K><K><E><S><A><C><V><R><L><F><K><Q><E><G><T><C><Y><Q><Q><A><K><L><V><L><N><T><A><V><P><D><R><L><P><A><R><E><R><E><M><D><V><I><R><N><F><L><R><E><H><I><C><G><K><K><A><G><S><L><Y><L><S><G><A><P><G><T><G><K><T><A><C><L><S><R><I><L><Q><D><L><K><K><E><L><K><G><F><K><T><I><M><L><N><C><M><S><L><R><T><A><Q><A><V><F><P><A><I><A><Q><E><I><C><Q><E><E><V><S><R><P><A><G><K><D><M><M><R><K><L><E><K><H><M><T><A><E><K><G><P><M><I><V><L><V><L><D><E><M><D><Q><L><D><S><K><G><Q><D><V><L><Y><T><L><F><E><W><P><W><L><S><N><S><H><L><V><L><I><G><I><A><N><T><L><D><L><T><D><R><I><L><P><R><L><Q><A><R><E><K><C><K><P><Q><L><L><N><F><P><P><Y><T><R><N><Q><I><V><T><I><L><Q><D><R><L><N><Q><V><S><R><D><Q><V><L><D><N><A><A><V><Q><F><C><A><R><K><V><S><A><V><S><G><D><V><R><K><A><L><D><V><C><R><R><A><I><E><I><V><E><S><D><V><K><S><Q><T><I><L><K><P><L><S><E><C><K><S><P><S><E><P><L><I><P><K><R><V><G><L><I><H><I><S><Q><V><I><S><E><V><D><G><N><R><M><T><L><S><Q><E><G><A><Q><D><S><F><P><L><Q><Q><K><I><L><V><C><S><L><M><L><L><I><R><Q><L><K><I><K><E><V><T><L><G><K><L><Y><E><A><Y><S><K><V><C><R><K><Q><Q><V><A><A><V><D><Q><S><E><C><L><S><L><S><G><L><L><E><A><R><G><I><L><G><L><K><R><N><K><E><T><R><L><T><K><V><F><F><K><I><E><E><K><E><I><E><H><A><L><K><D><K><A><L><I><G><N><I><L><A><T><G><L><P>
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.<BOP>
Q99741
Q9UL26
RB22A_HUMAN
Ras-related protein Rab-22A
Homo
<M><A><L><R><E><L><K><V><C><L><L><G><D><T><G><V><G><K><S><S><I><V><W><R><F><V><E><D><S><F><D><P><N><I><N><P><T><I><G><A><S><F><M><T><K><T><V><Q><Y><Q><N><E><L><H><K><F><L><I><W><D><T><A><G><Q><E><R><F><R><A><L><A><P><M><Y><Y><R><G><S><A><A><A><I><I><V><Y><D><I><T><K><E><E><T><F><S><T><L><K><N><W><V><K><E><L><R><Q><H><G><P><P><N><I><V><V><A><I><A><G><N><K><C><D><L><I><D><V><R><E><V><M><E><R><D><A><K><D><Y><A><D><S><I><H><A><I><F><V><E><T><S><A><K><N><A><I><N><I><N><E><L><F><I><E><I><S><R><R><I><P><S><T><D><A><N><L><P><S><G><G><K><G><F><K><L><R><R><Q><P><S><E><P><K><R><S><C><C>
Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes . Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth . Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form .<BOP>
Q9UL26
O75884
RBBP9_HUMAN
Retinoblastoma-binding protein 9
Homo
<M><A><S><P><S><K><A><V><I><V><P><G><N><G><G><G><D><V><T><T><H><G><W><Y><G><W><V><K><K><E><L><E><K><I><P><G><F><Q><C><L><A><K><N><M><P><D><P><I><T><A><R><E><S><I><W><L><P><F><M><E><T><E><L><H><C><D><E><K><T><I><I><I><G><H><S><S><G><A><I><A><A><M><R><Y><A><E><T><H><R><V><Y><A><I><V><L><V><S><A><Y><T><S><D><L><G><D><E><N><E><R><A><S><G><Y><F><T><R><P><W><Q><W><E><K><I><K><A><N><C><P><Y><I><V><Q><F><G><S><T><D><D><P><F><L><P><W><K><E><Q><Q><E><V><A><D><R><L><E><T><K><L><H><K><F><T><D><C><G><H><F><Q><N><T><E><F><H><E><L><I><T><V><V><K><S><L><L><K><V><P><A>
Serine hydrolase whose substrates have not been identified yet . May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation . May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 .<BOP>
O75884
P0DJD9
PEPA5_HUMAN
Pepsinogen-5
Homo
<M><K><W><L><L><L><L><G><L><V><A><L><S><E><C><I><M><Y><K><V><P><L><I><R><K><K><S><L><R><R><T><L><S><E><R><G><L><L><K><D><F><L><K><K><H><N><L><N><P><A><R><K><Y><F><P><Q><W><E><A><P><T><L><V><D><E><Q><P><L><E><N><Y><L><D><M><E><Y><F><G><T><I><G><I><G><T><P><A><Q><D><F><T><V><V><F><D><T><G><S><S><N><L><W><V><P><S><V><Y><C><S><S><L><A><C><T><N><H><N><R><F><N><P><E><D><S><S><T><Y><Q><S><T><S><E><T><V><S><I><T><Y><G><T><G><S><M><T><G><I><L><G><Y><D><T><V><Q><V><G><G><I><S><D><T><N><Q><I><F><G><L><S><E><T><E><P><G><S><F><L><Y><Y><A><P><F><D><G><I><L><G><L><A><Y><P><S><I><S><S><S><G><A><T><P><V><F><D><N><I><W><N><Q><G><L><V><S><Q><D><L><F><S><V><Y><L><S><A><D><D><K><S><G><S><V><V><I><F><G><G><I><D><S><S><Y><Y><T><G><S><L><N><W><V><P><V><T><V><E><G><Y><W><Q><I><T><V><D><S><I><T><M><N><G><E><T><I><A><C><A><E><G><C><Q><A><I><V><D><T><G><T><S><L><L><T><G><P><T><S><P><I><A><N><I><Q><S><D><I><G><A><S><E><N><S><D><G><D><M><V><V><S><C><S><A><I><S><S><L><P><D><I><V><F><T><I><N><G><V><Q><Y><P><V><P><P><S><A><Y><I><L><Q><S><E><G><S><C><I><S><G><F><Q><G><M><N><V><P><T><E><S><G><E><L><W><I><L><G><D><V><F><I><R><Q><Y><F><T><V><F><D><R><A><N><N><Q><V><G><L><A><P><V><A>
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.<BOP>
P0DJD9
Q8TE99
PXYP1_HUMAN
epididymis luminal protein 124
Homo
<M><L><F><R><N><R><F><L><L><L><L><A><L><A><A><L><L><A><F><V><S><L><S><L><Q><F><F><H><L><I><P><V><S><T><P><K><N><G><M><S><S><K><S><R><K><R><I><M><P><D><P><V><T><E><P><P><V><T><D><P><V><Y><E><A><L><L><Y><C><N><I><P><S><V><A><E><R><S><M><E><G><H><A><P><H><H><F><K><L><V><S><V><H><V><F><I><R><H><G><D><R><Y><P><L><Y><V><I><P><K><T><K><R><P><E><I><D><C><T><L><V><A><N><R><K><P><Y><H><P><K><L><E><A><F><I><S><H><M><S><K><G><S><G><A><S><F><E><S><P><L><N><S><L><P><L><Y><P><N><H><P><L><C><E><M><G><E><L><T><Q><T><G><V><V><Q><H><L><Q><N><G><Q><L><L><R><D><I><Y><L><K><K><H><K><L><L><P><N><D><W><S><A><D><Q><L><Y><L><E><T><T><G><K><S><R><T><L><Q><S><G><L><A><L><L><Y><G><F><L><P><D><F><D><W><K><K><I><Y><F><R><H><Q><P><S><A><L><F><C><S><G><S><C><Y><C><P><V><R><N><Q><Y><L><E><K><E><Q><R><R><Q><Y><L><L><R><L><K><N><S><Q><L><E><K><T><Y><G><E><M><A><K><I><V><D><V><P><T><K><Q><L><R><A><A><N><P><I><D><S><M><L><C><H><F><C><H><N><V><S><F><P><C><T><R><N><G><C><V><D><M><E><H><F><K><V><I><K><T><H><Q><I><E><D><E><R><E><R><R><E><K><K><L><Y><F><G><Y><S><L><L><G><A><H><P><I><L><N><Q><T><I><G><R><M><Q><R><A><T><E><G><R><K><E><E><L><F><A><L><Y><S><A><H><D><V><T><L><S><P><V><L><S><A><L><G><L><S><E><A><R><F><P><R><F><A><A><R><L><I><F><E><L><W><Q><D><R><E><K><P><S><E><H><S><V><R><I><L><Y><N><G><V><D><V><T><F><H><T><S><F><C><Q><D><H><H><K><R><S><P><K><P><M><C><P><L><E><N><L><V><R><F><V><K><R><D><M><F><V><A><L><G><G><S><G><T><N><Y><Y><D><A><C><H><R><E><G><F>
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.<BOP>
Q8TE99
Q9H3P2
NELFA_HUMAN
Wolf-Hirschhorn syndrome candidate 2 protein
Homo
<M><A><S><M><R><E><S><D><T><G><L><W><L><H><N><K><L><G><A><T><D><E><L><W><A><P><P><S><I><A><S><L><L><T><A><A><V><I><D><N><I><R><L><C><F><H><G><L><S><S><A><V><K><L><K><L><L><L><G><T><L><H><L><P><R><R><T><V><D><E><M><K><G><A><L><M><E><I><I><Q><L><A><S><L><D><S><D><P><W><V><L><M><V><A><D><I><L><K><S><F><P><D><T><G><S><L><N><L><E><L><E><E><Q><N><P><N><V><Q><D><I><L><G><E><L><R><E><K><V><G><E><C><E><A><S><A><M><L><P><L><E><C><Q><Y><L><N><K><N><A><L><T><T><L><A><G><P><L><T><P><P><V><K><H><F><Q><L><K><R><K><P><K><S><A><T><L><R><A><E><L><L><Q><K><S><T><E><T><A><Q><Q><L><K><R><S><A><G><V><P><F><H><A><K><G><R><G><L><L><R><K><M><D><T><T><T><P><L><K><G><I><P><K><Q><A><P><F><R><S><P><T><A><P><S><V><F><S><P><T><G><N><R><T><P><I><P><P><S><R><T><L><L><R><K><E><R><G><V><K><L><L><D><I><S><E><L><D><M><V><G><A><G><R><E><A><K><R><R><R><K><T><L><D><A><E><V><V><E><K><P><A><K><E><E><T><V><V><E><N><A><T><P><D><Y><A><A><G><L><V><S><T><Q><K><L><G><S><L><N><N><E><P><A><L><P><S><T><S><Y><L><P><S><T><P><S><V><V><P><A><S><S><Y><I><P><S><S><E><T><P><P><A><P><S><S><R><E><A><S><R><P><P><E><E><P><S><A><P><S><P><T><L><P><A><Q><F><K><Q><R><A><P><M><Y><N><S><G><L><S><P><A><T><P><T><P><A><A><P><T><S><P><L><T><P><T><T><P><P><A><V><A><P><T><T><Q><T><P><P><V><A><M><V><A><P><Q><T><Q><A><P><A><Q><Q><Q><P><K><K><N><L><S><L><T><R><E><Q><M><F><A><A><Q><E><M><F><K><T><A><N><K><V><T><R><P><E><K><A><L><I><L><G><F><M><A><G><S><R><E><N><P><C><Q><E><Q><G><D><V><I><Q><I><K><L><S><E><H><T><E><D><L><P><K><A><D><G><Q><G><S><T><T><M><L><V><D><T><V><F><E><M><N><Y><A><T><G><Q><W><T><R><F><K><K><Y><K><P><M><T><N><V><S>
(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.<BOP>
Q9H3P2
Q8IYX0
ZN679_HUMAN
Zinc finger protein 679
Homo
<M><A><K><R><P><G><S><P><G><S><R><E><M><G><L><L><T><F><R><D><V><V><I><E><F><S><L><E><E><W><Q><C><L><D><H><A><Q><Q><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><G><I><A><V><S><K><P><D><L><I><T><C><L><E><Q><N><K><E><P><W><N><I><K><R><N><E><M><V><T><K><H><P><V><M><C><S><H><F><T><Q><D><L><P><P><E><L><G><I><K><D><S><L><Q><K><V><I><P><R><R><Y><G><K><S><G><H><D><N><L><Q><V><K><T><C><K><S><M><G><E><C><E><V><Q><K><G><G><C><N><E><V><N><Q><C><L><S><T><T><Q><N><K><I><F><Q><T><H><K><C><V><K><V><F><G><K><F><S><N><S><N><R><H><K><T><R><H><T><G><K><K><H><F><K><C><K><K><Y><G><K><S><F><C><M><V><S><Q><L><H><Q><H><Q><I><I><H><T><R><E><N><S><Y><Q><C><E><E><C><G><K><P><F><N><C><S><S><T><L><S><K><H><K><R><I><H><T><G><E><K><P><Y><R><C><E><E><C><G><K><A><F><T><W><S><S><T><L><T><K><H><R><R><I><H><T><G><E><K><P><Y><T><C><E><E><C><G><Q><A><F><S><R><S><S><T><L><A><N><H><K><R><I><H><T><G><E><K><P><Y><T><C><E><E><C><G><K><A><F><S><L><S><S><S><L><T><Y><H><K><R><I><H><T><G><E><K><P><Y><T><C><E><E><C><G><K><A><F><N><C><S><S><T><L><K><K><H><K><I><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><A><F><S><S><T><L><N><T><H><K><R><I><H><T><G><E><E><P><Y><K><C><E><E><C><D><K><A><F><K><W><S><S><S><L><A><N><H><K><S><M><H><T><G><E><K><P><Y><K><C><E>
May be involved in transcriptional regulation.<BOP>
Q8IYX0
P55211
CASP9_HUMAN
Caspase-9 subunit p10
Homo
<M><D><E><A><D><R><R><L><L><R><R><C><R><L><R><L><V><E><E><L><Q><V><D><Q><L><W><D><A><L><L><S><R><E><L><F><R><P><H><M><I><E><D><I><Q><R><A><G><S><G><S><R><R><D><Q><A><R><Q><L><I><I><D><L><E><T><R><G><S><Q><A><L><P><L><F><I><S><C><L><E><D><T><G><Q><D><M><L><A><S><F><L><R><T><N><R><Q><A><A><K><L><S><K><P><T><L><E><N><L><T><P><V><V><L><R><P><E><I><R><K><P><E><V><L><R><P><E><T><P><R><P><V><D><I><G><S><G><G><F><G><D><V><G><A><L><E><S><L><R><G><N><A><D><L><A><Y><I><L><S><M><E><P><C><G><H><C><L><I><I><N><N><V><N><F><C><R><E><S><G><L><R><T><R><T><G><S><N><I><D><C><E><K><L><R><R><R><F><S><S><L><H><F><M><V><E><V><K><G><D><L><T><A><K><K><M><V><L><A><L><L><E><L><A><Q><Q><D><H><G><A><L><D><C><C><V><V><V><I><L><S><H><G><C><Q><A><S><H><L><Q><F><P><G><A><V><Y><G><T><D><G><C><P><V><S><V><E><K><I><V><N><I><F><N><G><T><S><C><P><S><L><G><G><K><P><K><L><F><F><I><Q><A><C><G><G><E><Q><K><D><H><G><F><E><V><A><S><T><S><P><E><D><E><S><P><G><S><N><P><E><P><D><A><T><P><F><Q><E><G><L><R><T><F><D><Q><L><D><A><I><S><S><L><P><T><P><S><D><I><F><V><S><Y><S><T><F><P><G><F><V><S><W><R><D><P><K><S><G><S><W><Y><V><E><T><L><D><D><I><F><E><Q><W><A><H><S><E><D><L><Q><S><L><L><L><R><V><A><N><A><V><S><V><K><G><I><Y><K><Q><M><P><G><C><F><N><F><L><R><K><K><L><F><F><K><T><S>
Lacks activity is an dominant-negative inhibitor of caspase-9.<BOP>
P55211
P24347
MMP11_HUMAN
Matrix metalloproteinase-11
Homo
<M><A><P><A><A><W><L><R><S><A><A><A><R><A><L><L><P><P><M><L><L><L><L><L><Q><P><P><P><L><L><A><R><A><L><P><P><D><A><H><H><L><H><A><E><R><R><G><P><Q><P><W><H><A><A><L><P><S><S><P><A><P><A><P><A><T><Q><E><A><P><R><P><A><S><S><L><R><P><P><R><C><G><V><P><D><P><S><D><G><L><S><A><R><N><R><Q><K><R><F><V><L><S><G><G><R><W><E><K><T><D><L><T><Y><R><I><L><R><F><P><W><Q><L><V><Q><E><Q><V><R><Q><T><M><A><E><A><L><K><V><W><S><D><V><T><P><L><T><F><T><E><V><H><E><G><R><A><D><I><M><I><D><F><A><R><Y><W><H><G><D><D><L><P><F><D><G><P><G><G><I><L><A><H><A><F><F><P><K><T><H><R><E><G><D><V><H><F><D><Y><D><E><T><W><T><I><G><D><D><Q><G><T><D><L><L><Q><V><A><A><H><E><F><G><H><V><L><G><L><Q><H><T><T><A><A><K><A><L><M><S><A><F><Y><T><F><R><Y><P><L><S><L><S><P><D><D><C><R><G><V><Q><H><L><Y><G><Q><P><W><P><T><V><T><S><R><T><P><A><L><G><P><Q><A><G><I><D><T><N><E><I><A><P><L><E><P><D><A><P><P><D><A><C><E><A><S><F><D><A><V><S><T><I><R><G><E><L><F><F><F><K><A><G><F><V><W><R><L><R><G><G><Q><L><Q><P><G><Y><P><A><L><A><S><R><H><W><Q><G><L><P><S><P><V><D><A><A><F><E><D><A><Q><G><H><I><W><F><F><Q><G><A><Q><Y><W><V><Y><D><G><E><K><P><V><L><G><P><A><P><L><T><E><L><G><L><V><R><F><P><V><H><A><A><L><V><W><G><P><E><K><N><K><I><Y><F><F><R><G><R><D><Y><W><R><F><H><P><S><T><R><R><V><D><S><P><V><P><R><R><A><T><D><W><R><G><V><P><S><E><I><D><A><A><F><Q><D><A><D><G><Y><A><Y><F><L><R><G><R><L><Y><W><K><F><D><P><V><K><V><K><A><L><E><G><F><P><R><L><V><G><P><D><F><F><G><C><A><E><P><A><N><T><F><L>
May play an important role in the progression of epithelial malignancies.<BOP>
P24347
P51811
XK_HUMAN
XK-related protein 1
Homo
<M><K><F><P><A><S><V><L><A><S><V><F><L><F><V><A><E><T><T><A><A><L><S><L><S><S><T><Y><R><S><G><G><D><R><M><W><Q><A><L><T><L><L><F><S><L><L><P><C><A><L><V><Q><L><T><L><L><F><V><H><R><D><L><S><R><D><R><P><L><V><L><L><L><H><L><L><Q><L><G><P><L><F><R><C><F><E><V><F><C><I><Y><F><Q><S><G><N><N><E><E><P><Y><V><S><I><T><K><K><R><Q><M><P><K><N><G><L><S><E><E><I><E><K><E><V><G><Q><A><E><G><K><L><I><T><H><R><S><A><F><S><R><A><S><V><I><Q><A><F><L><G><S><A><P><Q><L><T><L><Q><L><Y><I><S><V><M><Q><Q><D><V><T><V><G><R><S><L><L><M><T><I><S><L><L><S><I><V><Y><G><A><L><R><C><N><I><L><A><I><K><I><K><Y><D><E><Y><E><V><K><V><K><P><L><A><Y><V><C><I><F><L><W><R><S><F><E><I><A><T><R><V><V><V><L><V><L><F><T><S><V><L><K><T><W><V><V><V><I><I><L><I><N><F><F><S><F><F><L><Y><P><W><I><L><F><W><C><S><G><S><P><F><P><E><N><I><E><K><A><L><S><R><V><G><T><T><I><V><L><C><F><L><T><L><L><Y><T><G><I><N><M><F><C><W><S><A><V><Q><L><K><I><D><S><P><D><L><I><S><K><S><H><N><W><Y><Q><L><L><V><Y><Y><M><I><R><F><I><E><N><A><I><L><L><L><L><W><Y><L><F><K><T><D><I><Y><M><Y><V><C><A><P><L><L><V><L><Q><L><L><I><G><Y><C><T><A><I><L><F><M><L><V><F><Y><Q><F><F><H><P><C><K><K><L><F><S><S><S><V><S><E><G><F><Q><R><W><L><R><C><F><C><W><A><C><R><Q><Q><K><P><C><E><P><I><G><K><E><D><L><Q><S><S><R><D><R><D><E><T><P><S><S><S><K><T><S><P><E><P><G><Q><F><L><N><A><E><D><L><C><S><A>
Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane.<BOP>
P51811
P54709
AT1B3_HUMAN
Sodium/potassium-dependent ATPase subunit beta-3
Homo
<M><T><K><N><E><K><K><S><L><N><Q><S><L><A><E><W><K><L><F><I><Y><N><P><T><T><G><E><F><L><G><R><T><A><K><S><W><G><L><I><L><L><F><Y><L><V><F><Y><G><F><L><A><A><L><F><S><F><T><M><W><V><M><L><Q><T><L><N><D><E><V><P><K><Y><R><D><Q><I><P><S><P><G><L><M><V><F><P><K><P><V><T><A><L><E><Y><T><F><S><R><S><D><P><T><S><Y><A><G><Y><I><E><D><L><K><K><F><L><K><P><Y><T><L><E><E><Q><K><N><L><T><V><C><P><D><G><A><L><F><E><Q><K><G><P><V><Y><V><A><C><Q><F><P><I><S><L><L><Q><A><C><S><G><M><N><D><P><D><F><G><Y><S><Q><G><N><P><C><I><L><V><K><M><N><R><I><I><G><L><K><P><E><G><V><P><R><I><D><C><V><S><K><N><E><D><I><P><N><V><A><V><Y><P><H><N><G><M><I><D><L><K><Y><F><P><Y><Y><G><K><K><L><H><V><G><Y><L><Q><P><L><V><A><V><Q><V><S><F><A><P><N><N><T><G><K><E><V><T><V><E><C><K><I><D><G><S><A><N><L><K><S><Q><D><D><R><D><K><F><L><G><R><V><M><F><K><I><T><A><R><A>
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.<BOP>
P54709
O75398
DEAF1_HUMAN
Zinc finger MYND domain-containing protein 5
Homo
<M><E><D><S><D><S><A><A><K><Q><L><G><L><A><E><A><A><A><V><A><A><A><A><A><V><A><A><A><A><A><A><A><A><G><G><E><A><E><E><P><V><L><S><R><D><E><D><S><E><E><D><A><D><S><E><A><E><R><E><T><P><R><V><T><A><V><A><V><M><A><A><E><P><G><H><M><D><M><G><A><E><A><L><P><G><P><D><E><A><A><A><A><A><A><F><A><E><V><T><T><V><T><V><A><N><V><G><A><A><A><D><N><V><F><T><T><S><V><A><N><A><A><S><I><S><G><H><V><L><S><G><R><T><A><L><Q><I><G><D><S><L><N><T><E><K><A><T><L><I><V><V><H><T><D><G><S><I><V><E><T><T><G><L><K><G><P><A><A><P><L><T><P><G><P><Q><S><P><P><T><P><L><A><P><G><Q><E><K><G><G><T><K><Y><N><W><D><P><S><V><Y><D><S><E><L><P><V><R><C><R><N><I><S><G><T><L><Y><K><N><R><L><G><S><G><G><R><G><R><C><I><K><Q><G><E><N><W><Y><S><P><T><E><F><E><A><M><A><G><R><A><S><S><K><D><W><K><R><S><I><R><Y><A><G><R><P><L><Q><C><L><I><Q><D><G><I><L><N><P><H><A><A><S><C><T><C><A><A><C><C><D><D><M><T><L><S><G><P><V><R><L><F><V><P><Y><K><R><R><K><K><E><N><E><L><P><T><T><P><V><K><K><D><S><P><K><N><I><T><L><L><P><A><T><A><A><T><T><F><T><V><T><P><S><G><Q><I><T><T><S><G><A><L><T><F><D><R><A><S><T><V><E><A><T><A><V><I><S><E><S><P><A><Q><G><D><V><F><A><G><A><T><V><Q><E><A><S><V><Q><P><P><C><R><A><S><H><P><E><P><H><Y><P><G><Y><Q><D><S><C><Q><I><A><P><F><P><E><A><A><L><P><T><S><H><P><K><I><V><L><T><S><L><P><A><L><A><V><P><P><P><T><P><T><K><A><A><P><P><A><L><V><N><G><L><E><L><S><E><P><R><S><W><L><Y><L><E><E><M><V><N><S><L><L><N><T><A><Q><Q><L><K><T><L><F><E><Q><A><K><H><A><S><T><Y><R><E><A><A><T><N><Q><A><K><I><H><A><D><A><E><R><K><E><Q><S><C><V><N><C><G><R><E><A><M><S><E><C><T><G><C><H><K><V><N><Y><C><S><T><F><C><Q><R><K><D><W><K><D><H><Q><H><I><C><G><Q><S><A><A><V><T><V><Q><A><D><E><V><H><V><A><E><S><V><M><E><K><V><T><V>
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3.<BOP>
O75398
P32248
CCR7_HUMAN
MIP-3 beta receptor
Homo
<M><D><L><G><K><P><M><K><S><V><L><V><V><A><L><L><V><I><F><Q><V><C><L><C><Q><D><E><V><T><D><D><Y><I><G><D><N><T><T><V><D><Y><T><L><F><E><S><L><C><S><K><K><D><V><R><N><F><K><A><W><F><L><P><I><M><Y><S><I><I><C><F><V><G><L><L><G><N><G><L><V><V><L><T><Y><I><Y><F><K><R><L><K><T><M><T><D><T><Y><L><L><N><L><A><V><A><D><I><L><F><L><L><T><L><P><F><W><A><Y><S><A><A><K><S><W><V><F><G><V><H><F><C><K><L><I><F><A><I><Y><K><M><S><F><F><S><G><M><L><L><L><L><C><I><S><I><D><R><Y><V><A><I><V><Q><A><V><S><A><H><R><H><R><A><R><V><L><L><I><S><K><L><S><C><V><G><I><W><I><L><A><T><V><L><S><I><P><E><L><L><Y><S><D><L><Q><R><S><S><S><E><Q><A><M><R><C><S><L><I><T><E><H><V><E><A><F><I><T><I><Q><V><A><Q><M><V><I><G><F><L><V><P><L><L><A><M><S><F><C><Y><L><V><I><I><R><T><L><L><Q><A><R><N><F><E><R><N><K><A><I><K><V><I><I><A><V><V><V><V><F><I><V><F><Q><L><P><Y><N><G><V><V><L><A><Q><T><V><A><N><F><N><I><T><S><S><T><C><E><L><S><K><Q><L><N><I><A><Y><D><V><T><Y><S><L><A><C><V><R><C><C><V><N><P><F><L><Y><A><F><I><G><V><K><F><R><N><D><L><F><K><L><F><K><D><L><G><C><L><S><Q><E><Q><L><R><Q><W><S><S><C><R><H><I><R><R><S><S><M><S><V><E><A><E><T><T><T><T><F><S><P>
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.<BOP>
P32248
Q8N1C3
GBRG1_HUMAN
GABA(A) receptor subunit gamma-1
Homo
<M><G><P><L><K><A><F><L><F><S><P><F><L><L><R><S><Q><S><R><G><V><R><L><V><F><L><L><L><T><L><H><L><G><N><C><V><D><K><A><D><D><E><D><D><E><D><L><T><V><N><K><T><W><V><L><A><P><K><I><H><E><G><D><I><T><Q><I><L><N><S><L><L><Q><G><Y><D><N><K><L><R><P><D><I><G><V><R><P><T><V><I><E><T><D><V><Y><V><N><S><I><G><P><V><D><P><I><N><M><E><Y><T><I><D><I><I><F><A><Q><T><W><F><D><S><R><L><K><F><N><S><T><M><K><V><L><M><L><N><S><N><M><V><G><K><I><W><I><P><D><T><F><F><R><N><S><R><K><S><D><A><H><W><I><T><T><P><N><R><L><L><R><I><W><N><D><G><R><V><L><Y><T><L><R><L><T><I><N><A><E><C><Y><L><Q><L><H><N><F><P><M><D><E><H><S><C><P><L><E><F><S><S><Y><G><Y><P><K><N><E><I><E><Y><K><W><K><K><P><S><V><E><V><A><D><P><K><Y><W><R><L><Y><Q><F><A><F><V><G><L><R><N><S><T><E><I><T><H><T><I><S><G><D><Y><V><I><M><T><I><F><F><D><L><S><R><R><M><G><Y><F><T><I><Q><T><Y><I><P><C><I><L><T><V><V><L><S><W><V><S><F><W><I><N><K><D><A><V><P><A><R><T><S><L><G><I><T><T><V><L><T><M><T><T><L><S><T><I><A><R><K><S><L><P><K><V><S><Y><V><T><A><M><D><L><F><V><S><V><C><F><I><F><V><F><A><A><L><M><E><Y><G><T><L><H><Y><F><T><S><N><Q><K><G><K><T><A><T><K><D><R><K><L><K><N><K><A><S><M><T><P><G><L><H><P><G><S><T><L><I><P><M><N><N><I><S><V><P><Q><E><D><D><Y><G><Y><Q><C><L><E><G><K><D><C><A><S><F><F><C><C><F><E><D><C><R><T><G><S><W><R><E><G><R><I><H><I><R><I><A><K><I><D><S><Y><S><R><I><F><F><P><T><A><F><A><L><F><N><L><V><Y><W><V><G><Y><L><Y><L>
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.<BOP>
Q8N1C3
Q99819
GDIR3_HUMAN
Rho-GDI gamma
Homo
<M><L><G><L><D><A><C><E><L><G><A><Q><L><L><E><L><L><R><L><A><L><C><A><R><V><L><L><A><D><K><E><G><G><P><P><A><V><D><E><V><L><D><E><A><V><P><E><Y><R><A><P><G><R><K><S><L><L><E><I><R><Q><L><D><P><D><D><R><S><L><A><K><Y><K><R><V><L><L><G><P><L><P><P><A><V><D><P><S><L><P><N><V><Q><V><T><R><L><T><L><L><S><E><Q><A><P><G><P><V><V><M><D><L><T><G><D><L><A><V><L><K><D><Q><V><F><V><L><K><E><G><V><D><Y><R><V><K><I><S><F><K><V><H><R><E><I><V><S><G><L><K><C><L><H><H><T><Y><R><R><G><L><R><V><D><K><T><V><Y><M><V><G><S><Y><G><P><S><A><Q><E><Y><E><F><V><T><P><V><E><E><A><P><R><G><A><L><V><R><G><P><Y><L><V><V><S><L><F><T><D><D><D><R><T><H><H><L><S><W><E><W><G><L><C><I><C><Q><D><W><K><D>
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.<BOP>
Q99819
P30968
GNRHR_HUMAN
Gonadotropin-releasing hormone receptor
Homo
<M><A><N><S><A><S><P><E><Q><N><Q><N><H><C><S><A><I><N><N><S><I><P><L><M><Q><G><N><L><P><T><L><T><L><S><G><K><I><R><V><T><V><T><F><F><L><F><L><L><S><A><T><F><N><A><S><F><L><L><K><L><Q><K><W><T><Q><K><K><E><K><G><K><K><L><S><R><M><K><L><L><L><K><H><L><T><L><A><N><L><L><E><T><L><I><V><M><P><L><D><G><M><W><N><I><T><V><Q><W><Y><A><G><E><L><L><C><K><V><L><S><Y><L><K><L><F><S><M><Y><A><P><A><F><M><M><V><V><I><S><L><D><R><S><L><A><I><T><R><P><L><A><L><K><S><N><S><K><V><G><Q><S><M><V><G><L><A><W><I><L><S><S><V><F><A><G><P><Q><L><Y><I><F><R><M><I><H><L><A><D><S><S><G><Q><T><K><V><F><S><Q><C><V><T><H><C><S><F><S><Q><W><W><H><Q><A><F><Y><N><F><F><T><F><S><C><L><F><I><I><P><L><F><I><M><L><I><C><N><A><K><I><I><F><T><L><T><R><V><L><H><Q><D><P><H><E><L><Q><L><N><Q><S><K><N><N><I><P><R><A><R><L><K><T><L><K><M><T><V><A><F><A><T><S><F><T><V><C><W><T><P><Y><Y><V><L><G><I><W><Y><W><F><D><P><E><M><L><N><R><L><S><D><P><V><N><H><F><F><F><L><F><A><F><L><N><P><C><F><D><P><L><I><Y><G><Y><F><S><L>
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.<BOP>
P30968
P43489
TNR4_HUMAN
TAX transcriptionally-activated glycoprotein 1 receptor
Homo
<M><C><V><G><A><R><R><L><G><R><G><P><C><A><A><L><L><L><L><G><L><G><L><S><T><V><T><G><L><H><C><V><G><D><T><Y><P><S><N><D><R><C><C><H><E><C><R><P><G><N><G><M><V><S><R><C><S><R><S><Q><N><T><V><C><R><P><C><G><P><G><F><Y><N><D><V><V><S><S><K><P><C><K><P><C><T><W><C><N><L><R><S><G><S><E><R><K><Q><L><C><T><A><T><Q><D><T><V><C><R><C><R><A><G><T><Q><P><L><D><S><Y><K><P><G><V><D><C><A><P><C><P><P><G><H><F><S><P><G><D><N><Q><A><C><K><P><W><T><N><C><T><L><A><G><K><H><T><L><Q><P><A><S><N><S><S><D><A><I><C><E><D><R><D><P><P><A><T><Q><P><Q><E><T><Q><G><P><P><A><R><P><I><T><V><Q><P><T><E><A><W><P><R><T><S><Q><G><P><S><T><R><P><V><E><V><P><G><G><R><A><V><A><A><I><L><G><L><G><L><V><L><G><L><L><G><P><L><A><I><L><L><A><L><Y><L><L><R><R><D><Q><R><L><P><P><D><A><H><K><P><P><G><G><G><S><F><R><T><P><I><Q><E><E><Q><A><D><A><H><S><T><L><A><K><I>
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.<BOP>
P43489
A0A075B6Y3
TJA3_HUMAN
T cell receptor alpha joining 3
Homo
<G><Y><S><S><A><S><K><I><I><F><G><S><G><T><R><L><S><I><R><P>
J region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A075B6Y3
A8MPS7
YDJC_HUMAN
Carbohydrate deacetylase
Homo
<M><S><R><P><R><M><R><L><V><V><T><A><D><D><F><G><Y><C><P><R><R><D><E><G><I><V><E><A><F><L><A><G><A><V><T><S><V><S><L><L><V><N><G><A><A><T><E><S><A><A><E><L><A><R><R><H><S><I><P><T><G><L><H><A><N><L><S><E><G><R><P><V><G><P><A><R><R><G><A><S><S><L><L><G><P><E><G><F><F><L><G><K><M><G><F><R><E><A><V><A><A><G><D><V><D><L><P><Q><V><R><E><E><L><E><A><Q><L><S><C><F><R><E><L><L><G><R><A><P><T><H><A><D><G><H><Q><H><V><H><V><L><P><G><V><C><Q><V><F><A><E><A><L><Q><A><Y><G><V><R><F><T><R><L><P><L><E><R><G><V><G><G><C><T><W><L><E><A><P><A><R><A><F><A><C><A><V><E><R><D><A><R><A><A><V><G><P><F><S><R><H><G><L><R><W><T><D><A><F><V><G><L><S><T><C><G><R><H><M><S><A><H><R><V><S><G><A><L><A><R><V><L><E><G><T><L><A><G><H><T><L><T><A><E><L><M><A><H><P><G><Y><P><S><V><P><P><T><G><G><C><G><E><G><P><D><A><F><S><C><S><W><E><R><L><H><E><L><R><V><L><T><A><P><T><L><R><A><Q><L><A><Q><D><G><V><Q><L><C><A><L><D><D><L><D><S><K><R><P><G><E><E><V><P><C><E><P><T><L><E><P><F><L><E><P><S><L><L>
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.<BOP>
A8MPS7
O95750
FGF19_HUMAN
Fibroblast growth factor 19
Homo
<M><R><S><G><C><V><V><V><H><V><W><I><L><A><G><L><W><L><A><V><A><G><R><P><L><A><F><S><D><A><G><P><H><V><H><Y><G><W><G><D><P><I><R><L><R><H><L><Y><T><S><G><P><H><G><L><S><S><C><F><L><R><I><R><A><D><G><V><V><D><C><A><R><G><Q><S><A><H><S><L><L><E><I><K><A><V><A><L><R><T><V><A><I><K><G><V><H><S><V><R><Y><L><C><M><G><A><D><G><K><M><Q><G><L><L><Q><Y><S><E><E><D><C><A><F><E><E><E><I><R><P><D><G><Y><N><V><Y><R><S><E><K><H><R><L><P><V><S><L><S><S><A><K><Q><R><Q><L><Y><K><N><R><G><F><L><P><L><S><H><F><L><P><M><L><P><M><V><P><E><E><P><E><D><L><R><G><H><L><E><S><D><M><F><S><S><P><L><E><T><D><S><M><D><P><F><G><L><V><T><G><L><E><A><V><R><S><P><S><F><E><K>
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.<BOP>
O95750
O75951
LYZL6_HUMAN
Lysozyme-like protein 6
Homo
<M><T><K><A><L><L><I><Y><L><V><S><S><F><L><A><L><N><Q><A><S><L><I><S><R><C><D><L><A><Q><V><L><Q><L><E><D><L><D><G><F><E><G><Y><S><L><S><D><W><L><C><L><A><F><V><E><S><K><F><N><I><S><K><I><N><E><N><A><D><G><S><F><D><Y><G><L><F><Q><I><N><S><H><Y><W><C><N><D><Y><K><S><Y><S><E><N><L><C><H><V><D><C><Q><D><L><L><N><P><N><L><L><A><G><I><H><C><A><K><R><I><V><S><G><A><R><G><M><N><N><W><V><E><W><R><L><H><C><S><G><R><P><L><F><Y><W><L><T><G><C><R><L><R>
May be involved sperm-egg plasma membrane adhesion and fusion during fertilization . Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus . Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH . Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 .<BOP>
O75951
Q9BQ08
RETNB_HUMAN
RELMbeta
Homo
<M><G><P><S><S><C><L><L><L><I><L><I><P><L><L><Q><L><I><N><P><G><S><T><Q><C><S><L><D><S><V><M><D><K><K><I><K><D><V><L><N><S><L><E><Y><S><P><S><P><I><S><K><K><L><S><C><A><S><V><K><S><Q><G><R><P><S><S><C><P><A><G><M><A><V><T><G><C><A><C><G><Y><G><C><G><S><W><D><V><Q><L><E><T><T><C><H><C><Q><C><S><V><V><D><W><T><T><A><R><C><C><H><L><T>
Probable hormone.<BOP>
Q9BQ08
P49366
DHYS_HUMAN
Deoxyhypusine synthase
Homo
<M><E><G><S><L><E><R><E><A><P><A><G><A><L><A><A><V><L><K><H><S><S><T><L><P><P><E><S><T><Q><V><R><G><Y><D><F><N><R><G><V><N><Y><R><A><L><L><E><A><F><G><T><T><G><F><Q><A><T><N><F><G><R><A><V><Q><Q><V><N><A><M><I><E><K><K><L><E><P><L><S><Q><D><E><D><Q><H><A><D><L><T><Q><S><R><R><P><L><T><S><C><T><I><F><L><G><Y><T><S><N><L><I><S><S><G><I><R><E><T><I><R><Y><L><V><Q><H><N><M><V><D><V><L><V><T><T><A><G><G><V><E><E><D><L><I><K><C><L><A><P><T><Y><L><G><E><F><S><L><R><G><K><E><L><R><E><N><G><I><N><R><I><G><N><L><L><V><P><N><E><N><Y><C><K><F><E><D><W><L><M><P><I><L><D><Q><M><V><M><E><Q><N><T><E><G><V><K><W><T><P><S><K><M><I><A><R><L><G><K><E><I><N><N><P><E><S><V><Y><Y><W><A><Q><K><N><H><I><P><V><F><S><P><A><L><T><D><G><S><L><G><D><M><I><F><F><H><S><Y><K><N><P><G><L><V><L><D><I><V><E><D><L><R><L><I><N><T><Q><A><I><F><A><K><C><T><G><M><I><I><L><G><G><G><V><V><K><H><H><I><A><N><A><N><L><M><R><N><G><A><D><Y><A><V><Y><I><N><T><A><Q><E><F><D><G><S><D><S><G><A><R><P><D><E><A><V><S><W><G><K><I><R><V><D><A><Q><P><V><K><V><Y><A><D><A><S><L><V><F><P><L><L><V><A><E><T><F><A><Q><K><M><D><A><F><M><H><E><K><N><E><D>
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue . This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.<BOP>
P49366
Q8NH53
O52N1_HUMAN
Olfactory receptor OR11-61
Homo
<M><S><F><L><N><G><T><S><L><T><P><A><S><F><I><L><N><G><I><P><G><L><E><D><V><H><L><W><I><S><F><P><L><C><T><M><Y><S><I><A><I><T><G><N><F><G><L><M><Y><L><I><Y><C><D><E><A><L><H><R><P><M><Y><V><F><L><A><L><L><S><F><T><D><V><L><M><C><T><S><T><L><P><N><T><L><F><I><L><W><F><N><L><K><E><I><D><F><K><A><C><L><A><Q><M><F><F><V><H><T><F><T><G><M><E><S><G><V><L><M><L><M><A><L><D><H><C><V><A><I><C><F><P><L><R><Y><A><T><I><L><T><N><S><V><I><A><K><A><G><F><L><T><F><L><R><G><V><M><L><V><I><P><S><T><F><L><T><K><R><L><P><Y><C><K><G><N><V><I><P><H><T><Y><C><D><H><M><S><V><A><K><I><S><C><G><N><V><R><V><N><A><I><Y><G><L><I><V><A><L><L><I><G><G><F><D><I><L><C><I><T><I><S><Y><T><M><I><L><Q><A><V><V><S><L><S><S><A><D><A><R><Q><K><A><F><S><T><C><T><A><H><F><C><A><I><V><L><T><Y><V><P><A><F><F><T><F><F><T><H><H><F><G><G><H><T><I><P><L><H><I><H><I><I><M><A><N><L><Y><L><L><M><P><P><T><M><N><P><I><V><Y><G><V><K><T><R><Q><V><R><E><S><V><I><R><F><F><L><K><G><K><D><N><S><H><N><F>
Odorant receptor.<BOP>
Q8NH53
P17019
ZN708_HUMAN
Zinc finger protein KOX8
Homo
<M><G><P><L><T><F><M><D><V><A><I><E><F><S><L><E><E><W><Q><C><L><D><T><A><Q><Q><N><L><Y><R><N><V><M><L><E><N><Y><R><N><L><V><F><L><G><I><A><V><S><N><L><D><L><I><T><C><L><E><Q><G><K><E><P><W><N><M><K><R><H><E><M><A><A><K><P><P><A><M><C><S><H><F><A><K><D><L><R><P><E><Q><Y><I><K><N><S><F><Q><Q><V><I><L><R><R><Y><G><K><C><G><Y><Q><K><G><C><K><S><V><D><E><H><K><L><H><K><G><G><H><K><G><L><N><R><C><V><T><T><T><Q><S><K><I><V><Q><C><D><K><Y><V><K><V><F><H><K><Y><S><N><A><K><R><H><K><I><R><H><T><G><K><N><P><F><K><C><K><E><C><G><K><S><F><C><M><L><S><Q><L><T><Q><H><E><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><K><S><S><N><L><T><N><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><T><L><T><R><H><K><I><I><H><T><G><E><K><L><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><N><L><T><K><H><K><I><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><Q><S><S><N><L><T><N><H><K><K><I><H><T><G><E><K><P><Y><K><C><G><E><C><G><K><A><F><T><L><S><S><H><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><S><V><F><S><T><L><T><K><H><K><I><I><H><T><E><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><H><L><T><N><H><K><V><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><T><K><S><S><T><L><T><Y><H><K><V><I><H><T><G><K><K><P><Y><K><C><E><E><C><G><K><A><F><S><I><F><S><I><L><T><K><H><K><V><I><H><T><E><D><K><P><Y><K><C><E><E><C><G><K><T><F><N><Y><S><S><N><F><T><N><H><K><K><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><S><F><I><L><S><S><H><L><T><T><H><K><I><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><N><Q><S><S><T><L><M><K><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><P><N><L><T><K><H><K><R><I><H><T><K><E><K><P><Y><K><C><K>
May be involved in transcriptional regulation.<BOP>
P17019
A6NGD5
ZSA5C_HUMAN
Zinc finger and SCAN domain-containing protein 5C pseudogene
Homo
<M><A><A><N><C><T><S><S><W><S><L><G><E><S><C><N><S><P><G><S><E><P><P><Q><S><M><P><S><P><A><T><Q><L><G><N><H><D><S><D><P><E><T><C><H><V><N><F><R><M><F><S><C><P><K><E><S><D><P><I><Q><A><L><R><K><L><T><E><L><C><H><L><W><L><R><P><D><L><H><T><K><E><Q><I><L><D><M><L><V><M><E><Q><F><M><I><S><M><P><Q><E><L><Q><V><L><V><M><M><N><G><V><Q><S><C><K><D><L><E><D><L><L><R><N><N><R><R><P><K><K><W><S><V><V><S><F><L><G><K><E><Y><L><M><Q><E><S><D><V><E><M><A><E><A><P><A><S><V><R><D><D><P><R><H><V><S><S><Q><R><T><S><S><V><N><Q><M><C><P><E><E><G><Q><A><S><Q><E><L><Q><T><L><P><R><V><P><A><L><F><R><R><Q><E><E><D><F><L><L><P><E><T><T><V><M><K><G><D><P><K><A><L><R><P><K><P><T><L><E><K><D><L><E><E><D><R><E><E><N><P><G><L><T><S><P><E><P><Q><L><P><N><S><P><T><G><V><V><G><A><K><E><G><K><E><P><Q><K><R><A><S><V><E><N><V><D><A><D><T><P><S><A><C><V><V><E><R><E><A><S><T><H><S><G><S><R><G><D><A><L><N><L><R><G><L><K><R><S><K><P><D><A><T><S><I><S><Q><E><E><P><Q><G><E><A><T><P><V><G><N><R><E><S><P><G><Q><A><E><I><N><P><V><H><S><P><G><P><A><G><P><V><S><H><P><S><G><Q><E><V><K><E><L><L><P><F><A><C><E><V><C><G><K><R><F><K><Y><R><G><K><L><A><V><H><T><R><S><H><T><G><E><R><L><F><Q><C><N><L><C><G><K><R><F><M><Q><R><I><G><L><Q><F><H><Q><R><T><H><T><G><E><R><P><Y><T><C><D><I><C><Q><K><Q><F><T><Q><K><S><Y><L><K><C><H><K><R><S><H><T><G><E><K><P><F><E><C><K><D><C><K><K><V><F><T><Y><K><A><N><L><K><E><H><Q><R><I><H><S><G><E><K><P><H><K><C><S><K><C><P><R><A><F><G><R><P><A><T><L><R><R><H><Q><K><T><H><R><E><A><T><S><Q>
May be involved in transcriptional regulation.<BOP>
A6NGD5
P10909
CLUS_HUMAN
Complement cytolysis inhibitor b chain
Homo
<M><M><K><T><L><L><L><F><V><G><L><L><L><T><W><E><S><G><Q><V><L><G><D><Q><T><V><S><D><N><E><L><Q><E><M><S><N><Q><G><S><K><Y><V><N><K><E><I><Q><N><A><V><N><G><V><K><Q><I><K><T><L><I><E><K><T><N><E><E><R><K><T><L><L><S><N><L><E><E><A><K><K><K><K><E><D><A><L><N><E><T><R><E><S><E><T><K><L><K><E><L><P><G><V><C><N><E><T><M><M><A><L><W><E><E><C><K><P><C><L><K><Q><T><C><M><K><F><Y><A><R><V><C><R><S><G><S><G><L><V><G><R><Q><L><E><E><F><L><N><Q><S><S><P><F><Y><F><W><M><N><G><D><R><I><D><S><L><L><E><N><D><R><Q><Q><T><H><M><L><D><V><M><Q><D><H><F><S><R><A><S><S><I><I><D><E><L><F><Q><D><R><F><F><T><R><E><P><Q><D><T><Y><H><Y><L><P><F><S><L><P><H><R><R><P><H><F><F><F><P><K><S><R><I><V><R><S><L><M><P><F><S><P><Y><E><P><L><N><F><H><A><M><F><Q><P><F><L><E><M><I><H><E><A><Q><Q><A><M><D><I><H><F><H><S><P><A><F><Q><H><P><P><T><E><F><I><R><E><G><D><D><D><R><T><V><C><R><E><I><R><H><N><S><T><G><C><L><R><M><K><D><Q><C><D><K><C><R><E><I><L><S><V><D><C><S><T><N><N><P><S><Q><A><K><L><R><R><E><L><D><E><S><L><Q><V><A><E><R><L><T><R><K><Y><N><E><L><L><K><S><Y><Q><W><K><M><L><N><T><S><S><L><L><E><Q><L><N><E><Q><F><N><W><V><S><R><L><A><N><L><T><Q><G><E><D><Q><Y><Y><L><R><V><T><T><V><A><S><H><T><S><D><S><D><V><P><S><G><V><T><E><V><V><V><K><L><F><D><S><D><P><I><T><V><T><V><P><V><E><V><S><R><K><N><P><K><F><M><E><T><V><A><E><K><A><L><Q><E><Y><R><K><K><H><R><E><E>
Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity . Promotes cell death through interaction with BCL2L1 that releases and activates BAX .<BOP>
P10909
P60331
KR101_HUMAN
Keratin-associated protein 18.1
Homo
<M><A><A><S><T><M><S><V><C><S><S><A><C><S><D><S><W><Q><V><D><A><C><P><E><S><C><C><E><P><H><C><C><A><L><S><C><C><A><P><A><P><C><L><T><L><V><C><T><P><V><S><R><V><S><S><P><C><C><Q><A><A><C><E><P><S><P><C><Q><S><G><C><T><S><S><C><T><P><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><P><V><C><C><L><P><T><C><S><K><D><S><S><S><C><C><Q><Q><S><S><C><Q><P><T><C><C><A><S><S><S><S><Q><Q><S><C><C><V><P><V><C><C><K><P><V><C><Y><V><P><T><C><S><E><D><S><S><S><C><C><Q><Q><S><S><C><H><P><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><V><R><C><K><P><V><C><C><K><P><I><C><C><V><P><V><C><S><G><A><S><T><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><T><S><C><C><R><P><S><S><S><V><S><L><L><C><R><P><V><C><R><P><A><C><C><M><P><V><S><S><C><C><A><P><A><S><S><C><Q><A><S><C><C><R><P><A><S><C><V><S><L><L><C><R><P><A><C><S><R><P><A><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
P60331
P25963
IKBA_HUMAN
Major histocompatibility complex enhancer-binding protein MAD3
Homo
<M><F><Q><A><A><E><R><P><Q><E><W><A><M><E><G><P><R><D><G><L><K><K><E><R><L><L><D><D><R><H><D><S><G><L><D><S><M><K><D><E><E><Y><E><Q><M><V><K><E><L><Q><E><I><R><L><E><P><Q><E><V><P><R><G><S><E><P><W><K><Q><Q><L><T><E><D><G><D><S><F><L><H><L><A><I><I><H><E><E><K><A><L><T><M><E><V><I><R><Q><V><K><G><D><L><A><F><L><N><F><Q><N><N><L><Q><Q><T><P><L><H><L><A><V><I><T><N><Q><P><E><I><A><E><A><L><L><G><A><G><C><D><P><E><L><R><D><F><R><G><N><T><P><L><H><L><A><C><E><Q><G><C><L><A><S><V><G><V><L><T><Q><S><C><T><T><P><H><L><H><S><I><L><K><A><T><N><Y><N><G><H><T><C><L><H><L><A><S><I><H><G><Y><L><G><I><V><E><L><L><V><S><L><G><A><D><V><N><A><Q><E><P><C><N><G><R><T><A><L><H><L><A><V><D><L><Q><N><P><D><L><V><S><L><L><L><K><C><G><A><D><V><N><R><V><T><Y><Q><G><Y><S><P><Y><Q><L><T><W><G><R><P><S><T><R><I><Q><Q><Q><L><G><Q><L><T><L><E><N><L><Q><M><L><P><E><S><E><D><E><E><S><Y><D><T><E><S><E><F><T><E><F><T><E><D><E><L><P><Y><D><D><C><V><F><G><G><Q><R><L><T><L>
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.<BOP>
P25963
Q9NXW2
DJB12_HUMAN
DnaJ homolog subfamily B member 12
Homo
<M><E><S><N><K><D><E><A><E><R><C><I><S><I><A><L><K><A><I><Q><S><N><Q><P><D><R><A><L><R><F><L><E><K><A><Q><R><L><Y><P><T><P><R><V><R><A><L><I><E><S><L><N><Q><K><P><Q><T><A><G><D><Q><P><P><P><T><D><T><T><H><A><T><H><R><K><A><G><G><T><D><A><P><S><A><N><G><E><A><G><G><E><S><T><K><G><Y><T><A><E><Q><V><A><A><V><K><R><V><K><Q><C><K><D><Y><Y><E><I><L><G><V><S><R><G><A><S><D><E><D><L><K><K><A><Y><R><R><L><A><L><K><F><H><P><D><K><N><H><A><P><G><A><T><E><A><F><K><A><I><G><T><A><Y><A><V><L><S><N><P><E><K><R><K><Q><Y><D><Q><F><G><D><D><K><S><Q><A><A><R><H><G><H><G><H><G><D><F><H><R><G><F><E><A><D><I><S><P><E><D><L><F><N><M><F><F><G><G><G><F><P><S><S><N><V><H><V><Y><S><N><G><R><M><R><Y><T><Y><Q><Q><R><Q><D><R><R><D><N><Q><G><D><G><G><L><G><V><F><V><Q><L><M><P><I><L><I><L><I><L><V><S><A><L><S><Q><L><M><V><S><S><P><P><Y><S><L><S><P><R><P><S><V><G><H><I><H><R><R><V><T><D><H><L><G><V><V><Y><Y><V><G><D><T><F><S><E><E><Y><T><G><S><S><L><K><T><V><E><R><N><V><E><D><D><Y><I><A><N><L><R><N><N><C><W><K><E><K><Q><Q><K><E><G><L><L><Y><R><A><R><Y><F><G><D><T><D><M><Y><H><R><A><Q><K><M><G><T><P><S><C><S><R><L><S><E><V><Q><A><S><L><H><G>
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection .<BOP>
Q9NXW2
P23743
DGKA_HUMAN
Diglyceride kinase alpha
Homo
<M><A><K><E><R><G><L><I><S><P><S><D><F><A><Q><L><Q><K><Y><M><E><Y><S><T><K><K><V><S><D><V><L><K><L><F><E><D><G><E><M><A><K><Y><V><Q><G><D><A><I><G><Y><E><G><F><Q><Q><F><L><K><I><Y><L><E><V><D><N><V><P><R><H><L><S><L><A><L><F><Q><S><F><E><T><G><H><C><L><N><E><T><N><V><T><K><D><V><V><C><L><N><D><V><S><C><Y><F><S><L><L><E><G><G><R><P><E><D><K><L><E><F><T><F><K><L><Y><D><T><D><R><N><G><I><L><D><S><S><E><V><D><K><I><I><L><Q><M><M><R><V><A><E><Y><L><D><W><D><V><S><E><L><R><P><I><L><Q><E><M><M><K><E><I><D><Y><D><G><S><G><S><V><S><Q><A><E><W><V><R><A><G><A><T><T><V><P><L><L><V><L><L><G><L><E><M><T><L><K><D><D><G><Q><H><M><W><R><P><K><R><F><P><R><P><V><Y><C><N><L><C><E><S><S><I><G><L><G><K><Q><G><L><S><C><N><L><C><K><Y><T><V><H><D><Q><C><A><M><K><A><L><P><C><E><V><S><T><Y><A><K><S><R><K><D><I><G><V><Q><S><H><V><W><V><R><G><G><C><E><S><G><R><C><D><R><C><Q><K><K><I><R><I><Y><H><S><L><T><G><L><H><C><V><W><C><H><L><E><I><H><D><D><C><L><Q><A><V><G><H><E><C><D><C><G><L><L><R><D><H><I><L><P><P><S><S><I><Y><P><S><V><L><A><S><G><P><D><R><K><N><S><K><T><S><Q><K><T><M><D><D><L><N><L><S><T><S><E><A><L><R><I><D><P><V><P><N><T><H><P><L><L><V><F><V><N><P><K><S><G><G><K><Q><G><Q><R><V><L><W><K><F><Q><Y><I><L><N><P><R><Q><V><F><N><L><L><K><D><G><P><E><I><G><L><R><L><F><K><D><V><P><D><S><R><I><L><V><C><G><G><D><G><T><V><G><W><I><L><E><T><I><D><K><A><N><L><P><V><L><P><P><V><A><V><L><P><L><G><T><G><N><D><L><A><R><C><L><R><W><G><G><G><Y><E><G><Q><N><L><A><K><I><L><K><D><L><E><M><S><K><V><V><H><M><D><R><W><S><V><E><V><I><P><Q><Q><T><E><E><K><S><D><P><V><P><F><Q><I><I><N><N><Y><F><S><I><G><V><D><A><S><I><A><H><R><F><H><I><M><R><E><K><Y><P><E><K><F><N><S><R><M><K><N><K><L><W><Y><F><E><F><A><T><S><E><S><I><F><S><T><C><K><K><L><E><E><S><L><T><V><E><I><C><G><K><P><L><D><L><S><N><L><S><L><E><G><I><A><V><L><N><I><P><S><M><H><G><G><S><N><L><W><G><D><T><R><R><P><H><G><D><I><Y><G><I><N><Q><A><L><G><A><T><A><K><V><I><T><D><P><D><I><L><K><T><C><V><P><D><L><S><D><K><R><L><E><V><V><G><L><E><G><A><I><E><M><G><Q><I><Y><T><K><L><K><N><A><G><R><R><L><A><K><C><S><E><I><T><F><H><T><T><K><T><L><P><M><Q><I><D><G><E><P><W><M><Q><T><P><C><T><I><K><I><T><H><K><N><Q><M><P><M><L><M><G><P><P><P><R><S><T><N><F><F><G><F><L><S>
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes . Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group . Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol .<BOP>
P23743
D6RJB6
U17LK_HUMAN
Ubiquitin carboxyl-terminal hydrolase 17-like protein 20
Homo
<M><E><D><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y><M><L><S><R><E><H><S><Q><T><C><H><R><H><K><G><C><M><L><C><T><M><Q><A><H><I><T><R><A><L><H><N><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><A><H><E><F><L><M><F><T><V><D><A><M><K><K><A><C><L><P><G><H><K><Q><V><D><H><H><S><K><D><T><T><L><I><H><Q><I><F><G><G><Y><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><Q><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><V><C><L><Q><R><A><P><A><S><K><T><L><T><L><H><T><S><A><K><V><L><I><L><V><L><K><R><F><S><D><V><T><G><N><K><I><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><P><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><N><G><H><Y><F><S><Y><V><K><A><Q><E><G><Q><W><Y><K><M><D><D><A><E><V><T><A><S><S><I><T><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><A><E><D><T><D><R><R><A><T><Q><G><E><L><K><R><D><H><P><C><L><Q><A><P><E><L><D><E><H><L><V><E><R><A><T><Q><E><S><T><L><D><H><W><K><F><L><Q><E><Q><N><K><T><K><P><E><F><N><V><R><K><V><E><G><T><L><P><P><D><V><L><V><I><H><Q><S><K><Y><K><C><G><M><K><N><H><H><P><E><Q><Q><S><S><L><L><N><L><S><S><T><T><P><T><H><Q><E><S><M><N><T><G><T><L><A><S><L><R><G><R><A><R><R><S><K><G><K><N><K><H><S><K><R><A><L><L><V><C><Q>
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP>
D6RJB6
Q06203
PUR1_HUMAN
Glutamine phosphoribosylpyrophosphate amidotransferase
Homo
<M><E><L><E><E><L><G><I><R><E><E><C><G><V><F><G><C><I><A><S><G><E><W><P><T><Q><L><D><V><P><H><V><I><T><L><G><L><V><G><L><Q><H><R><G><Q><E><S><A><G><I><V><T><S><D><G><S><S><V><P><T><F><K><S><H><K><G><M><G><L><V><N><H><V><F><T><E><D><N><L><K><K><L><Y><V><S><N><L><G><I><G><H><T><R><Y><A><T><T><G><K><C><E><L><E><N><C><Q><P><F><V><V><E><T><L><H><G><K><I><A><V><A><H><N><G><E><L><V><N><A><A><R><L><R><K><K><L><L><R><H><G><I><G><L><S><T><S><S><D><S><E><M><I><T><Q><L><L><A><Y><T><P><P><Q><E><Q><D><D><T><P><D><W><V><A><R><I><K><N><L><M><K><E><A><P><T><A><Y><S><L><L><I><M><H><R><D><V><I><Y><A><V><R><D><P><Y><G><N><R><P><L><C><I><G><R><L><I><P><V><S><D><I><N><D><K><E><K><K><T><S><E><T><E><G><W><V><V><S><S><E><S><C><S><F><L><S><I><G><A><R><Y><Y><R><E><V><L><P><G><E><I><V><E><I><S><R><H><N><V><Q><T><L><D><I><I><S><R><S><E><G><N><P><V><A><F><C><I><F><E><Y><V><Y><F><A><R><P><D><S><M><F><E><D><Q><M><V><Y><T><V><R><Y><R><C><G><Q><Q><L><A><I><E><A><P><V><D><A><D><L><V><S><T><V><P><E><S><A><T><P><A><A><L><A><Y><A><G><K><C><G><L><P><Y><V><E><V><L><C><K><N><R><Y><V><G><R><T><F><I><Q><P><N><M><R><L><R><Q><L><G><V><A><K><K><F><G><V><L><S><D><N><F><K><G><K><R><I><V><L><V><D><D><S><I><V><R><G><N><T><I><S><P><I><I><K><L><L><K><E><S><G><A><K><E><V><H><I><R><V><A><S><P><P><I><K><Y><P><C><F><M><G><I><N><I><P><T><K><E><E><L><I><A><N><K><P><E><F><D><H><L><A><E><Y><L><G><A><N><S><V><V><Y><L><S><V><E><G><L><V><S><S><V><Q><E><G><I><K><F><K><K><Q><K><E><K><K><H><D><I><M><I><Q><E><N><G><N><G><L><E><C><F><E><K><S><G><H><C><T><A><C><L><T><G><K><Y><P><V><E><L><E><W>
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.<BOP>
Q06203
Q86YT9
JAML_HUMAN
Dendritic cell-specific protein CREA7-1
Homo
<M><F><C><P><L><K><L><I><L><L><P><V><L><L><D><Y><S><L><G><L><N><D><L><N><V><S><P><P><E><L><T><V><H><V><G><D><S><A><L><M><G><C><V><F><Q><S><T><E><D><K><C><I><F><K><I><D><W><T><L><S><P><G><E><H><A><K><D><E><Y><V><L><Y><Y><Y><S><N><L><S><V><P><I><G><R><F><Q><N><R><V><H><L><M><G><D><I><L><C><N><D><G><S><L><L><L><Q><D><V><Q><E><A><D><Q><G><T><Y><I><C><E><I><R><L><K><G><E><S><Q><V><F><K><K><A><V><V><L><H><V><L><P><E><E><P><K><E><L><M><V><H><V><G><G><L><I><Q><M><G><C><V><F><Q><S><T><E><V><K><H><V><T><K><V><E><W><I><F><S><G><R><R><A><K><E><E><I><V><F><R><Y><Y><H><K><L><R><M><S><V><E><Y><S><Q><S><W><G><H><F><Q><N><R><V><N><L><V><G><D><I><F><R><N><D><G><S><I><M><L><Q><G><V><R><E><S><D><G><G><N><Y><T><C><S><I><H><L><G><N><L><V><F><K><K><T><I><V><L><H><V><S><P><E><E><P><R><T><L><V><T><P><A><A><L><R><P><L><V><L><G><G><N><Q><L><V><I><I><V><G><I><V><C><A><T><I><L><L><L><P><V><L><I><L><I><V><K><K><T><C><G><N><K><S><S><V><N><S><T><V><L><V><K><N><T><K><K><T><N><P><E><I><K><E><K><P><C><H><F><E><R><C><E><G><E><K><H><I><Y><S><P><I><I><V><R><E><V><I><E><E><E><E><P><S><E><K><S><E><A><T><Y><M><T><M><H><P><V><W><P><S><L><R><S><D><R><N><N><S><L><E><K><K><S><G><G><G><M><P><K><T><Q><Q><A><F>
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.<BOP>
Q86YT9
O14492
SH2B2_HUMAN
SH2 and PH domain-containing adapter protein APS
Homo
<M><N><G><A><G><P><G><P><A><A><A><A><P><V><P><V><P><V><P><V><P><D><W><R><Q><F><C><E><L><H><A><Q><A><A><A><V><D><F><A><H><K><F><C><R><F><L><R><D><N><P><A><Y><D><T><P><D><A><G><A><S><F><S><R><H><F><A><A><N><F><L><D><V><F><G><E><E><V><R><R><V><L><V><A><G><P><T><T><R><G><A><A><V><S><A><E><A><M><E><P><E><L><A><D><T><S><A><L><K><A><A><P><Y><G><H><S><R><S><S><E><D><V><S><T><H><A><A><T><K><A><R><V><R><K><G><F><S><L><R><N><M><S><L><C><V><V><D><G><V><R><D><M><W><H><R><R><A><S><P><E><P><D><A><A><A><A><P><R><T><A><E><P><R><D><K><W><T><R><R><L><R><L><S><R><T><L><A><A><K><V><E><L><V><D><I><Q><R><E><G><A><L><R><F><M><V><A><D><D><A><A><A><G><S><G><G><S><A><Q><W><Q><K><C><R><L><L><L><R><R><A><V><A><E><E><R><F><R><L><E><F><F><V><P><P><K><A><S><R><P><K><V><S><I><P><L><S><A><I><I><E><V><R><T><T><M><P><L><E><M><P><E><K><D><N><T><F><V><L><K><V><E><N><G><A><E><Y><I><L><E><T><I><D><S><L><Q><K><H><S><W><V><A><D><I><Q><G><C><V><D><P><G><D><S><E><E><D><T><E><L><S><C><T><R><G><G><C><L><A><S><R><V><A><S><C><S><C><E><L><L><T><D><A><V><D><L><P><R><P><P><E><T><T><A><V><G><A><V><V><T><A><P><H><S><R><G><R><D><A><V><R><E><S><L><I><H><V><P><L><E><T><F><L><Q><T><L><E><S><P><G><G><S><G><S><D><S><N><N><T><G><E><Q><G><A><E><T><D><P><E><A><E><P><E><L><E><L><S><D><Y><P><W><F><H><G><T><L><S><R><V><K><A><A><Q><L><V><L><A><G><G><P><R><N><H><G><L><F><V><I><R><Q><S><E><T><R><P><G><E><Y><V><L><T><F><N><F><Q><G><K><A><K><H><L><R><L><S><L><N><G><H><G><Q><C><H><V><Q><H><L><W><F><Q><S><V><L><D><M><L><R><H><F><H><T><H><P><I><P><L><E><S><G><G><S><A><D><I><T><L><R><S><Y><V><R><A><Q><D><P><P><P><E><P><G><P><T><P><P><A><A><P><A><S><P><A><C><W><S><D><S><P><G><Q><H><Y><F><S><S><L><A><A><A><A><C><P><P><A><S><P><S><D><A><A><G><A><S><S><S><S><A><S><S><S><S><A><A><S><G><P><A><P><P><R><P><V><E><G><Q><L><S><A><R><S><R><S><N><S><A><E><R><L><L><E><A><V><A><A><T><A><A><E><E><P><P><E><A><A><P><G><R><A><R><A><V><E><N><Q><Y><S><F><Y>
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.<BOP>
O14492
Q8NG80
OR2L5_HUMAN
Olfactory receptor OR1-53
Homo
<M><E><N><Y><N><Q><T><S><T><D><F><I><L><L><G><L><F><P><P><S><K><I><G><L><F><L><F><I><L><F><V><L><I><F><L><M><A><L><I><G><N><L><S><M><I><L><L><I><F><L><D><T><H><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><I><D><L><N><Y><I><S><T><I><V><P><K><M><A><S><D><F><L><Y><G><N><K><S><I><S><F><I><G><C><G><I><Q><S><F><F><F><M><T><F><A><G><A><E><A><L><L><L><T><S><M><A><Y><D><R><Y><V><A><I><C><F><P><L><H><Y><P><I><R><M><S><K><R><M><Y><V><L><M><I><T><G><S><W><M><I><G><S><I><N><S><C><A><H><T><V><Y><A><F><R><I><P><Y><C><K><S><R><A><I><N><H><F><F><C><D><V><P><A><M><L><T><L><A><C><T><D><T><W><V><Y><E><Y><T><V><F><L><S><S><T><I><F><L><V><F><P><F><T><G><I><A><C><S><Y><G><W><V><L><L><A><V><Y><R><M><H><S><A><E><G><R><K><K><A><Y><S><T><C><S><T><H><L><T><V><V><T><F><Y><Y><A><P><F><A><Y><T><Y><L><C><P><R><S><L><R><S><L><T><E><D><K><V><L><A><V><F><Y><T><I><L><T><P><M><L><N><P><I><I><Y><S><L><R><N><K><E><V><M><G><A><L><T><R><V><I><Q><N><I><F><S><V><K><M>
Odorant receptor.<BOP>
Q8NG80
Q9NQ03
SCRT2_HUMAN
Scratch homolog 2 zinc finger protein
Homo
<M><P><R><S><F><L><V><K><K><I><K><G><D><G><F><Q><C><S><G><V><P><A><P><T><Y><H><P><L><E><T><A><Y><V><L><P><G><A><R><G><P><P><G><D><N><G><Y><A><P><H><R><L><P><P><S><S><Y><D><A><D><Q><K><P><G><L><E><L><A><P><A><E><P><A><Y><P><P><A><A><P><E><E><Y><S><D><P><E><S><P><Q><S><S><L><S><A><R><Y><F><R><G><E><A><A><V><T><D><S><Y><S><M><D><A><F><F><I><S><D><G><R><S><R><R><R><R><G><G><G><G><G><D><A><G><G><S><G><D><A><G><G><A><G><G><R><A><G><R><A><G><A><Q><A><G><G><G><H><R><H><A><C><A><E><C><G><K><T><Y><A><T><S><S><N><L><S><R><H><K><Q><T><H><R><S><L><D><S><Q><L><A><R><K><C><P><T><C><G><K><A><Y><V><S><M><P><A><L><A><M><H><L><L><T><H><N><L><R><H><K><C><G><V><C><G><K><A><F><S><R><P><W><L><L><Q><G><H><M><R><S><H><T><G><E><K><P><F><G><C><A><H><C><G><K><A><F><A><D><R><S><N><L><R><A><H><M><Q><T><H><S><A><F><K><H><Y><R><C><R><Q><C><D><K><S><F><A><L><K><S><Y><L><H><K><H><C><E><A><A><C><A><K><A><A><E><P><P><P><P><T><P><A><G><P><A><S>
May be involved in transcriptional regulation.<BOP>
Q9NQ03
Q7L7L0
H2A3_HUMAN
H2A-clustered histone 25
Homo
<M><S><G><R><G><K><Q><G><G><K><A><R><A><K><A><K><S><R><S><S><R><A><G><L><Q><F><P><V><G><R><V><H><R><L><L><R><K><G><N><Y><S><E><R><V><G><A><G><A><P><V><Y><L><A><A><V><L><E><Y><L><T><A><E><I><L><E><L><A><G><N><A><A><R><D><N><K><K><T><R><I><I><P><R><H><L><Q><L><A><I><R><N><D><E><E><L><N><K><L><L><G><R><V><T><I><A><Q><G><G><V><L><P><N><I><Q><A><V><L><L><P><K><K><T><E><S><H><H><K><A><K><G><K>
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP>
Q7L7L0
Q99797
MIPEP_HUMAN
Mitochondrial intermediate peptidase
Homo
<M><L><C><V><G><R><L><G><G><L><G><A><R><A><A><A><L><P><P><R><R><A><G><R><G><S><L><E><A><G><I><R><A><R><R><V><S><T><S><W><S><P><V><G><A><A><F><N><V><K><P><Q><G><S><R><L><D><L><F><G><E><R><R><G><L><F><G><V><P><E><L><S><A><P><E><G><F><H><I><A><Q><E><K><A><L><R><K><T><E><L><L><V><D><R><A><C><S><T><P><P><G><P><Q><T><V><L><I><F><D><E><L><S><D><S><L><C><R><V><A><D><L><A><D><F><V><K><I><A><H><P><E><P><A><F><R><E><A><A><E><E><A><C><R><S><I><G><T><M><V><E><K><L><N><T><N><V><D><L><Y><Q><S><L><Q><K><L><L><A><D><K><K><L><V><D><S><L><D><P><E><T><R><R><V><A><E><L><F><M><F><D><F><E><I><S><G><I><H><L><D><K><E><K><R><K><R><A><V><D><L><N><V><K><I><L><D><L><S><S><T><F><L><M><G><T><N><F><P><N><K><I><E><K><H><L><L><P><E><H><I><R><R><N><F><T><S><A><G><D><H><I><I><I><D><G><L><H><A><E><S><P><D><D><L><V><R><E><A><A><Y><K><I><F><L><Y><P><N><A><G><Q><L><K><C><L><E><E><L><L><S><S><R><D><L><L><A><K><L><V><G><Y><S><T><F><S><H><R><A><L><Q><G><T><I><A><K><N><P><E><T><V><M><Q><F><L><E><K><L><S><D><K><L><S><E><R><T><L><K><D><F><E><M><I><R><G><M><K><M><K><L><N><P><Q><N><S><E><V><M><P><W><D><P><P><Y><Y><S><G><V><I><R><A><E><R><Y><N><I><E><P><S><L><Y><C><P><F><F><S><L><G><A><C><M><E><G><L><N><I><L><L><N><R><L><L><G><I><S><L><Y><A><E><Q><P><A><K><G><E><V><W><S><E><D><V><R><K><L><A><V><V><H><E><S><E><G><L><L><G><Y><I><Y><C><D><F><F><Q><R><A><D><K><P><H><Q><D><C><H><F><T><I><R><G><G><R><L><K><E><D><G><D><Y><Q><L><P><V><V><V><L><M><L><N><L><P><R><S><S><R><S><S><P><T><L><L><T><P><S><M><M><E><N><L><F><H><E><M><G><H><A><M><H><S><M><L><G><R><T><R><Y><Q><H><V><T><G><T><R><C><P><T><D><F><A><E><V><P><S><I><L><M><E><Y><F><A><N><D><Y><R><V><V><N><Q><F><A><R><H><Y><Q><T><G><Q><P><L><P><K><N><M><V><S><R><L><C><E><S><K><K><V><C><A><A><A><D><M><Q><L><Q><V><F><Y><A><T><L><D><Q><I><Y><H><G><K><H><P><L><R><N><S><T><T><D><I><L><K><E><T><Q><E><K><F><Y><G><L><P><Y><V><P><N><T><A><W><Q><L><R><F><S><H><L><V><G><Y><G><A><R><Y><Y><S><Y><L><M><S><R><A><V><A><S><M><V><W><K><E><C><F><L><Q><D><P><F><N><R><A><A><G><E><R><Y><R><R><E><M><L><A><H><G><G><G><R><E><P><M><L><M><V><E><G><M><L><Q><K><C><P><S><V><D><D><F><V><S><A><L><V><S><D><L><D><L><D><F><E><T><F><L><M><D><S><E>
Cleaves proteins, imported into the mitochondrion, to their mature size.<BOP>
Q99797
P17480
UBF1_HUMAN
Upstream-binding factor 1
Homo
<M><N><G><E><A><D><C><P><T><D><L><E><M><A><A><P><K><G><Q><D><R><W><S><Q><E><D><M><L><T><L><L><E><C><M><K><N><N><L><P><S><N><D><S><S><K><F><K><T><T><E><S><H><M><D><W><E><K><V><A><F><K><D><F><S><G><D><M><C><K><L><K><W><V><E><I><S><N><E><V><R><K><F><R><T><L><T><E><L><I><L><D><A><Q><E><H><V><K><N><P><Y><K><G><K><K><L><K><K><H><P><D><F><P><K><K><P><L><T><P><Y><F><R><F><F><M><E><K><R><A><K><Y><A><K><L><H><P><E><M><S><N><L><D><L><T><K><I><L><S><K><K><Y><K><E><L><P><E><K><K><K><M><K><Y><I><Q><D><F><Q><R><E><K><Q><E><F><E><R><N><L><A><R><F><R><E><D><H><P><D><L><I><Q><N><A><K><K><S><D><I><P><E><K><P><K><T><P><Q><Q><L><W><Y><T><H><E><K><K><V><Y><L><K><V><R><P><D><A><T><T><K><E><V><K><D><S><L><G><K><Q><W><S><Q><L><S><D><K><K><R><L><K><W><I><H><K><A><L><E><Q><R><K><E><Y><E><E><I><M><R><D><Y><I><Q><K><H><P><E><L><N><I><S><E><E><G><I><T><K><S><T><L><T><K><A><E><R><Q><L><K><D><K><F><D><G><R><P><T><K><P><P><P><N><S><Y><S><L><Y><C><A><E><L><M><A><N><M><K><D><V><P><S><T><E><R><M><V><L><C><S><Q><Q><W><K><L><L><S><Q><K><E><K><D><A><Y><H><K><K><C><D><Q><K><K><K><D><Y><E><V><E><L><L><R><F><L><E><S><L><P><E><E><E><Q><Q><R><V><L><G><E><E><K><M><L><N><I><N><K><K><Q><A><T><S><P><A><S><K><K><P><A><Q><E><G><G><K><G><G><S><E><K><P><K><R><P><V><S><A><M><F><I><F><S><E><E><K><R><R><Q><L><Q><E><E><R><P><E><L><S><E><S><E><L><T><R><L><L><A><R><M><W><N><D><L><S><E><K><K><K><A><K><Y><K><A><R><E><A><A><L><K><A><Q><S><E><R><K><P><G><G><E><R><E><E><R><G><K><L><P><E><S><P><K><R><A><E><E><I><W><Q><Q><S><V><I><G><D><Y><L><A><R><F><K><N><D><R><V><K><A><L><K><A><M><E><M><T><W><N><N><M><E><K><K><E><K><L><M><W><I><K><K><A><A><E><D><Q><K><R><Y><E><R><E><L><S><E><M><R><A><P><P><A><A><T><N><S><S><K><K><M><K><F><Q><G><E><P><K><K><P><P><M><N><G><Y><Q><K><F><S><Q><E><L><L><S><N><G><E><L><N><H><L><P><L><K><E><R><M><V><E><I><G><S><R><W><Q><R><I><S><Q><S><Q><K><E><H><Y><K><K><L><A><E><E><Q><Q><K><Q><Y><K><V><H><L><D><L><W><V><K><S><L><S><P><Q><D><R><A><A><Y><K><E><Y><I><S><N><K><R><K><S><M><T><K><L><R><G><P><N><P><K><S><S><R><T><T><L><Q><S><K><S><E><S><E><E><D><D><E><E><D><E><D><D><E><D><E><D><E><E><E><E><D><D><E><N><G><D><S><S><E><D><G><G><D><S><S><E><S><S><S><E><D><E><S><E><D><G><D><E><N><E><E><D><D><E><D><E><D><D><D><E><D><D><D><E><D><E><D><N><E><S><E><G><S><S><S><S><S><S><S><S><G><D><S><S><D><S><D><S><N>
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.<BOP>
P17480
Q9Y5X0
SNX10_HUMAN
Sorting nexin-10
Homo
<M><F><P><E><Q><Q><K><E><E><F><V><S><V><W><V><R><D><P><R><I><Q><K><E><D><F><W><H><S><Y><I><D><Y><E><I><C><I><H><T><N><S><M><C><F><T><M><K><T><S><C><V><R><R><R><Y><R><E><F><V><W><L><R><Q><R><L><Q><S><N><A><L><L><V><Q><L><P><E><L><P><S><K><N><L><F><F><N><M><N><N><R><Q><H><V><D><Q><R><R><Q><G><L><E><D><F><L><R><K><V><L><Q><N><A><L><L><L><S><D><S><S><L><H><L><F><L><Q><S><H><L><N><S><E><D><I><E><A><C><V><S><G><Q><T><K><Y><S><V><E><E><A><I><H><K><F><A><L><M><N><R><R><F><P><E><E><D><E><E><G><K><K><E><N><D><I><D><Y><D><S><E><S><S><S><S><G><L><G><H><S><S><D><D><S><S><S><H><G><C><K><V><N><T><A><P><Q><E><S>
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.<BOP>
Q9Y5X0
Q8ND82
Z280C_HUMAN
Zinc finger protein 633
Homo
<M><D><D><D><K><P><F><Q><P><K><N><I><S><K><M><A><E><L><F><M><E><C><E><E><E><E><L><E><P><W><Q><K><K><V><E><E><T><Q><D><E><D><D><D><E><L><I><F><V><G><E><I><S><S><S><K><P><A><I><S><N><I><L><N><R><G><H><S><S><S><S><S><K><G><I><K><S><E><P><H><S><P><G><I><P><E><I><F><R><T><A><S><Q><R><C><R><D><P><P><S><N><P><V><A><A><S><P><R><F><H><L><V><S><K><S><S><Q><S><S><V><T><V><E><N><A><S><K><P><D><F><T><K><N><S><Q><V><G><S><D><N><S><S><I><L><L><F><D><S><T><Q><E><S><L><P><P><S><Q><D><I><P><A><I><F><R><E><G><M><K><N><T><S><Y><V><L><K><H><P><S><T><S><K><V><N><S><V><T><P><K><K><P><K><T><S><E><D><V><P><Q><I><N><P><S><T><S><L><P><L><I><G><S><P><P><V><T><S><S><Q><V><M><L><S><K><G><T><N><T><S><S><P><Y><D><A><G><A><D><Y><L><R><A><C><P><K><C><N><V><Q><F><N><L><L><D><P><L><K><Y><H><M><K><H><C><C><P><D><M><I><T><K><F><L><G><V><I><V><K><S><E><R><P><C><D><E><D><K><T><D><S><E><T><G><K><L><I><M><L><V><N><E><F><Y><Y><G><R><H><E><G><V><T><E><K><E><P><K><T><Y><T><T><F><K><C><F><S><C><S><K><V><L><K><N><N><I><R><F><M><N><H><M><K><H><H><L><E><L><E><K><Q><N><N><E><S><W><E><N><H><T><T><C><Q><H><C><Y><R><Q><Y><P><T><P><F><Q><L><Q><C><H><I><E><S><T><H><T><P><H><E><F><S><T><I><C><K><I><C><E><L><S><F><E><T><E><H><I><L><L><Q><H><M><K><D><T><H><K><P><G><E><M><P><Y><V><C><Q><V><C><Q><F><R><S><S><T><F><S><D><V><E><A><H><F><R><A><A><H><E><N><T><K><N><L><L><C><P><F><C><L><K><V><S><K><M><A><T><P><Y><M><N><H><Y><M><K><H><Q><K><K><G><V><H><R><C><P><K><C><R><L><Q><F><L><T><S><K><E><K><A><E><H><K><A><Q><H><R><T><F><I><K><P><K><E><L><E><G><L><P><P><G><A><K><V><T><I><R><A><S><L><G><P><L><Q><S><K><L><P><T><A><P><F><G><C><A><P><G><T><S><F><L><Q><V><T><P><P><T><S><Q><N><T><T><A><R><N><P><R><K><S><N><A><S><R><S><K><T><S><K><L><H><A><T><T><S><T><A><S><K><V><N><T><S><K><P><R><G><R><I><A><K><S><K><A><K><P><S><Y><K><Q><K><R><Q><R><N><R><K><N><K><M><S><L><A><L><K><N><I><R><C><R><R><G><I><H><K><C><I><E><C><H><S><K><I><K><D><F><A><S><H><F><S><I><Y><I><H><C><S><F><C><K><Y><N><T><N><C><N><K><A><F><V><N><H><M><M><S><S><H><S><N><H><P><G><K><R><F><C><I><F><K><K><H><S><G><T><L><R><G><I><T><L><V><C><L><K><C><D><F><L><A><D><S><S><G><L><D><R><M><A><K><H><L><S><Q><R><K><T><H><T><C><Q><V><I><I><E><N><V><S><K><S><T><S><T><S><E><P><T><T><G><C><S><L><K>
May function as a transcription factor.<BOP>
Q8ND82
P0C025
NUD17_HUMAN
Nucleoside diphosphate-linked moiety X motif 17
Homo
<M><A><E><V><R><V><Q><L><L><L><S><R><R><P><E><S><V><S><F><A><R><S><V><C><G><L><L><G><A><G><P><G><L><G><T><W><P><I><H><C><S><L><K><R><G><R><L><V><L><S><S><R><P><F><P><G><A><S><A><R><L><P><L><Q><R><P><P><F><C><P><F><A><A><L><E><E><R><P><R><V><P><G><A><E><L><P><T><D><R><G><V><D><L><G><V><A><V><I><L><Q><S><S><D><K><T><V><L><L><T><R><R><A><R><T><L><S><V><S><P><N><L><W><V><P><P><G><G><H><V><E><L><E><E><E><L><L><D><G><G><L><R><E><L><W><E><E><S><G><L><H><L><P><Q><G><Q><F><S><W><V><P><L><G><L><W><E><S><A><Y><P><P><R><L><S><W><G><L><P><K><Y><H><H><I><V><L><Y><L><L><V><I><S><Q><E><S><Q><Q><Q><L><Q><A><R><I><Q><P><N><P><N><E><V><S><A><L><M><W><L><T><P><D><V><A><A><A><V><A><A><A><E><D><G><T><E><T><P><G><L><L><P><Q><D><L><P><P><S><V><L><A><V><E><L><E><E><D><G><R><A><R><P><L><V><L><H><M><S><T><L><L><R><M><I><P><T><M><A><E><D><K><E><R><V><S><T><G><T><K><F><A><L><K><L><W><L><Q><H><L><G><R><T><P><P><P><C><K><S><A><A><Y><L><D><P><G><P><A><K><E><E><W><N><M><D><P><L><P><P><N><Q><G><S><G><K>
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.<BOP>
P0C025
O75879
GATB_HUMAN
Cytochrome c oxidase assembly factor PET112 homolog
Homo
<M><A><A><P><M><L><R><W><G><C><R><G><R><R><W><A><F><A><R><V><D><G><G><S><C><H><R><R><G><A><P><T><G><S><T><S><N><Q><I><R><G><E><S><S><V><A><Q><Q><P><L><H><T><A><Q><K><T><R><K><G><E><H><K><W><A><A><V><V><G><L><E><I><H><A><Q><I><S><S><N><S><K><L><F><S><G><S><Q><V><R><F><S><A><P><P><N><S><L><V><S><F><F><D><A><S><L><P><G><T><L><P><V><L><N><R><R><C><V><E><A><A><V><M><T><G><L><A><L><N><C><H><I><N><K><K><S><L><F><D><R><K><H><Y><F><Y><A><D><L><P><A><G><Y><Q><I><T><Q><Q><R><L><P><I><A><V><N><G><S><L><I><Y><G><V><C><A><G><K><K><Q><S><Q><V><I><P><K><T><V><R><I><K><Q><I><Q><L><E><Q><D><S><G><K><S><L><H><D><N><L><R><S><Q><T><L><I><D><L><N><R><A><G><V><G><L><L><E><V><V><L><E><P><D><M><S><C><G><E><E><A><A><T><A><V><R><E><L><Q><L><I><L><Q><A><L><G><T><S><Q><A><N><M><A><E><G><Q><L><R><V><D><A><N><I><S><V><H><H><P><G><E><P><L><G><V><R><T><E><V><K><N><L><N><S><I><R><F><L><A><K><A><I><D><Y><E><I><Q><R><Q><I><N><E><L><E><N><G><G><E><I><L><N><E><T><R><S><F><H><H><K><L><G><C><T><M><S><M><R><D><K><E><G><K><Q><D><Y><R><F><M><P><E><P><N><L><P><P><L><V><L><Y><D><A><T><S><L><P><A><G><A><D><P><Q><Q><V><I><N><I><D><Q><I><R><E><T><L><P><E><L><P><S><V><T><R><E><K><L><V><Q><Q><Y><G><M><L><L><E><H><S><F><T><L><L><N><E><V><G><L><L><E><F><F><Q><N><V><I><K><E><T><R><A><E><P><K><K><V><T><S><W><V><L><N><T><F><L><G><Y><L><K><Q><Q><N><L><A><V><S><E><S><P><V><T><P><S><A><L><A><E><L><L><D><L><L><D><S><R><T><I><S><S><S><A><A><K><Q><V><F><E><E><L><W><K><R><E><G><K><T><P><G><Q><I><V><S><E><K><Q><L><E><L><M><Q><D><Q><G><A><L><E><Q><L><C><H><S><V><M><E><A><H><P><Q><V><V><M><D><V><K><N><R><N><P><R><A><I><N><K><L><I><G><L><V><R><K><A><T><Q><S><R><A><D><P><V><M><I><K><E><I><L><E><K><K><L><S><L>
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).<BOP>
O75879
Q8NHC8
OR2T6_HUMAN
Olfactory receptor 2T9
Homo
<M><N><E><N><N><E><T><L><T><R><G><F><T><L><M><G><L><F><T><H><N><K><C><S><G><F><F><F><G><V><I><C><A><V><F><F><M><A><M><I><A><N><G><V><M><I><F><L><I><N><I><D><P><H><L><H><T><P><M><Y><F><L><L><S><H><L><S><V><I><D><T><L><Y><I><S><T><I><V><P><K><M><L><V><D><Y><L><M><G><E><G><T><I><S><F><I><A><C><T><A><Q><C><F><L><Y><M><G><F><M><G><A><E><F><F><L><L><G><L><M><A><Y><D><R><Y><V><A><I><C><N><P><L><R><Y><P><V><L><I><S><W><R><V><C><W><M><I><L><A><S><S><W><F><G><G><A><L><D><S><F><L><L><T><P><I><T><M><S><L><P><F><C><A><S><H><Q><I><N><H><F><F><C><E><A><P><T><M><L><R><L><A><C><G><D><K><T><T><Y><E><T><V><M><Y><V><C><C><V><A><M><L><L><I><P><F><S><V><V><T><A><S><Y><T><R><I><L><I><T><V><H><Q><M><T><S><A><E><G><R><K><K><A><F><A><T><C><S><S><H><M><M><V><V><T><L><F><Y><G><A><A><L><Y><T><Y><T><L><P><Q><S><Y><H><T><P><I><K><D><K><V><F><S><A><F><Y><T><I><L><T><P><L><L><N><P><L><I><Y><S><L><R><N><R><D><V><M><G><A><L><K><R><V><V><A><R><C>
Odorant receptor.<BOP>
Q8NHC8
O00748
EST2_HUMAN
Methylumbelliferyl-acetate deacetylase 2
Homo
<M><R><L><H><R><L><R><A><R><L><S><A><V><A><C><G><L><L><L><L><L><V><R><G><Q><G><Q><D><S><A><S><P><I><R><T><T><H><T><G><Q><V><L><G><S><L><V><H><V><K><G><A><N><A><G><V><Q><T><F><L><G><I><P><F><A><K><P><P><L><G><P><L><R><F><A><P><P><E><P><P><E><S><W><S><G><V><R><D><G><T><T><H><P><A><M><C><L><Q><D><L><T><A><V><E><S><E><F><L><S><Q><F><N><M><T><F><P><S><D><S><M><S><E><D><C><L><Y><L><S><I><Y><T><P><A><H><S><H><E><G><S><N><L><P><V><M><V><W><I><H><G><G><A><L><V><F><G><M><A><S><L><Y><D><G><S><M><L><A><A><L><E><N><V><V><V><V><I><I><Q><Y><R><L><G><V><L><G><F><F><S><T><G><D><K><H><A><T><G><N><W><G><Y><L><D><Q><V><A><A><L><R><W><V><Q><Q><N><I><A><H><F><G><G><N><P><D><R><V><T><I><F><G><E><S><A><G><G><T><S><V><S><S><L><V><V><S><P><I><S><Q><G><L><F><H><G><A><I><M><E><S><G><V><A><L><L><P><G><L><I><A><S><S><A><D><V><I><S><T><V><V><A><N><L><S><A><C><D><Q><V><D><S><E><A><L><V><G><C><L><R><G><K><S><K><E><E><I><L><A><I><N><K><P><F><K><M><I><P><G><V><V><D><G><V><F><L><P><R><H><P><Q><E><L><L><A><S><A><D><F><Q><P><V><P><S><I><V><G><V><N><N><N><E><F><G><W><L><I><P><K><V><M><R><I><Y><D><T><Q><K><E><M><D><R><E><A><S><Q><A><A><L><Q><K><M><L><T><L><L><M><L><P><P><T><F><G><D><L><L><R><E><E><Y><I><G><D><N><G><D><P><Q><T><L><Q><A><Q><F><Q><E><M><M><A><D><S><M><F><V><I><P><A><L><Q><V><A><H><F><Q><C><S><R><A><P><V><Y><F><Y><E><F><Q><H><Q><P><S><W><L><K><N><I><R><P><P><H><M><K><A><D><H><G><D><E><L><P><F><V><F><R><S><F><F><G><G><N><Y><I><K><F><T><E><E><E><E><Q><L><S><R><K><M><M><K><Y><W><A><N><F><A><R><N><G><N><P><N><G><E><G><L><P><H><W><P><L><F><D><Q><E><E><Q><Y><L><Q><L><N><L><Q><P><A><V><G><R><A><L><K><A><H><R><L><Q><F><W><K><K><A><L><P><Q><K><I><Q><E><L><E><E><P><E><E><R><H><T><E><L>
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs . Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine . Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol . Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins .<BOP>
O00748
O14678
ABCD4_HUMAN
Peroxisomal membrane protein 69
Homo
<M><A><V><A><G><P><A><P><G><A><G><A><R><P><R><L><D><L><Q><F><L><Q><R><F><L><Q><I><L><K><V><L><F><P><S><W><S><S><Q><N><A><L><M><F><L><T><L><L><C><L><T><L><L><E><Q><F><V><I><Y><Q><V><G><L><I><P><S><Q><Y><Y><G><V><L><G><N><K><D><L><E><G><F><K><T><L><T><F><L><A><V><M><L><I><V><L><N><S><T><L><K><S><F><D><Q><F><T><C><N><L><L><Y><V><S><W><R><K><D><L><T><E><H><L><H><R><L><Y><F><R><G><R><A><Y><Y><T><L><N><V><L><R><D><D><I><D><N><P><D><Q><R><I><S><Q><D><V><E><R><F><C><R><Q><L><S><S><M><A><S><K><L><I><I><S><P><F><T><L><V><Y><Y><T><Y><Q><C><F><Q><S><T><G><W><L><G><P><V><S><I><F><G><Y><F><I><L><G><T><V><V><N><K><T><L><M><G><P><I><V><M><K><L><V><H><Q><E><K><L><E><G><D><F><R><F><K><H><M><Q><I><R><V><N><A><E><P><A><A><F><Y><R><A><G><H><V><E><H><M><R><T><D><R><R><L><Q><R><L><L><Q><T><Q><R><E><L><M><S><K><E><L><W><L><Y><I><G><I><N><T><F><D><Y><L><G><S><I><L><S><Y><V><V><I><A><I><P><I><F><S><G><V><Y><G><D><L><S><P><A><E><L><S><T><L><V><S><K><N><A><F><V><C><I><Y><L><I><S><C><F><T><Q><L><I><D><L><S><T><T><L><S><D><V><A><G><Y><T><H><R><I><G><Q><L><R><E><T><L><L><D><M><S><L><K><S><Q><D><C><E><I><L><G><E><S><E><W><G><L><D><T><P><P><G><W><P><A><A><E><P><A><D><T><A><F><L><L><E><R><V><S><I><S><A><P><S><S><D><K><P><L><I><K><D><L><S><L><K><I><S><E><G><Q><S><L><L><I><T><G><N><T><G><T><G><K><T><S><L><L><R><V><L><G><G><L><W><T><S><T><R><G><S><V><Q><M><L><T><D><F><G><P><H><G><V><L><F><L><P><Q><K><P><F><F><T><D><G><T><L><R><E><Q><V><I><Y><P><L><K><E><V><Y><P><D><S><G><S><A><D><D><E><R><I><L><R><F><L><E><L><A><G><L><S><N><L><V><A><R><T><E><G><L><D><Q><Q><V><D><W><N><W><Y><D><V><L><S><P><G><E><M><Q><R><L><S><F><A><R><L><F><Y><L><Q><P><K><Y><A><V><L><D><E><A><T><S><A><L><T><E><E><V><E><S><E><L><Y><R><I><G><Q><Q><L><G><M><T><F><I><S><V><G><H><R><Q><S><L><E><K><F><H><S><L><V><L><K><L><C><G><G><G><R><W><E><L><M><R><I><K><V><E>
Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner . Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane . Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane .<BOP>
O14678
Q9NQX3
GEPH_HUMAN
Domain E
Homo
<M><A><T><E><G><M><I><L><T><N><H><D><H><Q><I><R><V><G><V><L><T><V><S><D><S><C><F><R><N><L><A><E><D><R><S><G><I><N><L><K><D><L><V><Q><D><P><S><L><L><G><G><T><I><S><A><Y><K><I><V><P><D><E><I><E><E><I><K><E><T><L><I><D><W><C><D><E><K><E><L><N><L><I><L><T><T><G><G><T><G><F><A><P><R><D><V><T><P><E><A><T><K><E><V><I><E><R><E><A><P><G><M><A><L><A><M><L><M><G><S><L><N><V><T><P><L><G><M><L><S><R><P><V><C><G><I><R><G><K><T><L><I><I><N><L><P><G><S><K><K><G><S><Q><E><C><F><Q><F><I><L><P><A><L><P><H><A><I><D><L><L><R><D><A><I><V><K><V><K><E><V><H><D><E><L><E><D><L><P><S><P><P><P><P><L><S><P><P><P><T><T><S><P><H><K><Q><T><E><D><K><G><V><Q><C><E><E><E><E><E><E><K><K><D><S><G><V><A><S><T><E><D><S><S><S><S><H><I><T><A><A><A><I><A><A><K><I><P><D><S><I><I><S><R><G><V><Q><V><L><P><R><D><T><A><S><L><S><T><T><P><S><E><S><P><R><A><Q><A><T><S><R><L><S><T><A><S><C><P><T><P><K><V><Q><S><R><C><S><S><K><E><N><I><L><R><A><S><H><S><A><V><D><I><T><K><V><A><R><R><H><R><M><S><P><F><P><L><T><S><M><D><K><A><F><I><T><V><L><E><M><T><P><V><L><G><T><E><I><I><N><Y><R><D><G><M><G><R><V><L><A><Q><D><V><Y><A><K><D><N><L><P><P><F><P><A><S><V><K><D><G><Y><A><V><R><A><A><D><G><P><G><D><R><F><I><I><G><E><S><Q><A><G><E><Q><P><T><Q><T><V><M><P><G><Q><V><M><R><V><T><T><G><A><P><I><P><C><G><A><D><A><V><V><Q><V><E><D><T><E><L><I><R><E><S><D><D><G><T><E><E><L><E><V><R><I><L><V><Q><A><R><P><G><Q><D><I><R><P><I><G><H><D><I><K><R><G><E><C><V><L><A><K><G><T><H><M><G><P><S><E><I><G><L><L><A><T><V><G><V><T><E><V><E><V><N><K><F><P><V><V><A><V><M><S><T><G><N><E><L><L><N><P><E><D><D><L><L><P><G><K><I><R><D><S><N><R><S><T><L><L><A><T><I><Q><E><H><G><Y><P><T><I><N><L><G><I><V><G><D><N><P><D><D><L><L><N><A><L><N><E><G><I><S><R><A><D><V><I><I><T><S><G><G><V><S><M><G><E><K><D><Y><L><K><Q><V><L><D><I><D><L><H><A><Q><I><H><F><G><R><V><F><M><K><P><G><L><P><T><T><F><A><T><L><D><I><D><G><V><R><K><I><I><F><A><L><P><G><N><P><V><S><A><V><V><T><C><N><L><F><V><V><P><A><L><R><K><M><Q><G><I><L><D><P><R><P><T><I><I><K><A><R><L><S><C><D><V><K><L><D><P><R><P><E><Y><H><R><C><I><L><T><W><H><H><Q><E><P><L><P><W><A><Q><S><T><G><N><Q><M><S><S><R><L><M><S><M><R><S><A><N><G><L><L><M><L><P><P><K><T><E><Q><Y><V><E><L><H><K><G><E><V><V><D><V><M><V><I><G><R><L>
Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<BOP>
Q9NQX3
Q13619
CUL4A_HUMAN
Cullin-4A
Homo
<M><A><D><E><A><P><R><K><G><S><F><S><A><L><V><G><R><T><N><G><L><T><K><P><A><A><L><A><A><A><P><A><K><P><G><G><A><G><G><S><K><K><L><V><I><K><N><F><R><D><R><P><R><L><P><D><N><Y><T><Q><D><T><W><R><K><L><H><E><A><V><R><A><V><Q><S><S><T><S><I><R><Y><N><L><E><E><L><Y><Q><A><V><E><N><L><C><S><H><K><V><S><P><M><L><Y><K><Q><L><R><Q><A><C><E><D><H><V><Q><A><Q><I><L><P><F><R><E><D><S><L><D><S><V><L><F><L><K><K><I><N><T><C><W><Q><D><H><C><R><Q><M><I><M><I><R><S><I><F><L><F><L><D><R><T><Y><V><L><Q><N><S><T><L><P><S><I><W><D><M><G><L><E><L><F><R><T><H><I><I><S><D><K><M><V><Q><S><K><T><I><D><G><I><L><L><L><I><E><R><E><R><S><G><E><A><V><D><R><S><L><L><R><S><L><L><G><M><L><S><D><L><Q><V><Y><K><D><S><F><E><L><K><F><L><E><E><T><N><C><L><Y><A><A><E><G><Q><R><L><M><Q><E><R><E><V><P><E><Y><L><N><H><V><S><K><R><L><E><E><E><G><D><R><V><I><T><Y><L><D><H><S><T><Q><K><P><L><I><A><C><V><E><K><Q><L><L><G><E><H><L><T><A><I><L><Q><K><G><L><D><H><L><L><D><E><N><R><V><P><D><L><A><Q><M><Y><Q><L><F><S><R><V><R><G><G><Q><Q><A><L><L><Q><H><W><S><E><Y><I><K><T><F><G><T><A><I><V><I><N><P><E><K><D><K><D><M><V><Q><D><L><L><D><F><K><D><K><V><D><H><V><I><E><V><C><F><Q><K><N><E><R><F><V><N><L><M><K><E><S><F><E><T><F><I><N><K><R><P><N><K><P><A><E><L><I><A><K><H><V><D><S><K><L><R><A><G><N><K><E><A><T><D><E><E><L><E><R><T><L><D><K><I><M><I><L><F><R><F><I><H><G><K><D><V><F><E><A><F><Y><K><K><D><L><A><K><R><L><L><V><G><K><S><A><S><V><D><A><E><K><S><M><L><S><K><L><K><H><E><C><G><A><A><F><T><S><K><L><E><G><M><F><K><D><M><E><L><S><K><D><I><M><V><H><F><K><Q><H><M><Q><N><Q><S><D><S><G><P><I><D><L><T><V><N><I><L><T><M><G><Y><W><P><T><Y><T><P><M><E><V><H><L><T><P><E><M><I><K><L><Q><E><V><F><K><A><F><Y><L><G><K><H><S><G><R><K><L><Q><W><Q><T><T><L><G><H><A><V><L><K><A><E><F><K><E><G><K><K><E><F><Q><V><S><L><F><Q><T><L><V><L><L><M><F><N><E><G><D><G><F><S><F><E><E><I><K><M><A><T><G><I><E><D><S><E><L><R><R><T><L><Q><S><L><A><C><G><K><A><R><V><L><I><K><S><P><K><G><K><E><V><E><D><G><D><K><F><I><F><N><G><E><F><K><H><K><L><F><R><I><K><I><N><Q><I><Q><M><K><E><T><V><E><E><Q><V><S><T><T><E><R><V><F><Q><D><R><Q><Y><Q><I><D><A><A><I><V><R><I><M><K><M><R><K><T><L><G><H><N><L><L><V><S><E><L><Y><N><Q><L><K><F><P><V><K><P><G><D><L><K><K><R><I><E><S><L><I><D><R><D><Y><M><E><R><D><K><D><N><P><N><Q><Y><H><Y><V><A>
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins . As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme . The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 . The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component . DCX(DET1-COP1) directs ubiquitination of JUN . DCX(DDB2) directs ubiquitination of XPC . DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition . DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1
Q13619
P55290
CAD13_HUMAN
Truncated cadherin
Homo
<M><Q><P><R><T><P><L><V><L><C><V><L><L><S><Q><V><L><L><L><T><S><A><E><D><L><D><C><T><P><G><F><Q><Q><K><V><F><H><I><N><Q><P><A><E><F><I><E><D><Q><S><I><L><N><L><T><F><S><D><C><K><G><N><D><K><L><R><Y><E><V><S><S><P><Y><F><K><V><N><S><D><G><G><L><V><A><L><R><N><I><T><A><V><G><K><T><L><F><V><H><A><R><T><P><H><A><E><D><M><A><E><L><V><I><V><G><G><K><D><I><Q><G><S><L><Q><D><I><F><K><F><A><R><T><S><P><V><P><R><Q><K><R><S><I><V><V><S><P><I><L><I><P><E><N><Q><R><Q><P><F><P><R><D><V><G><K><V><V><D><S><D><R><P><E><R><S><K><F><R><L><T><G><K><G><V><D><Q><E><P><K><G><I><F><R><I><N><E><N><T><G><S><V><S><V><T><R><T><L><D><R><E><V><I><A><V><Y><Q><L><F><V><E><T><T><D><V><N><G><K><T><L><E><G><P><V><P><L><E><V><I><V><I><D><Q><N><D><N><R><P><I><F><R><E><G><P><Y><I><G><H><V><M><E><G><S><P><T><G><T><T><V><M><R><M><T><A><F><D><A><D><D><P><A><T><D><N><A><L><L><R><Y><N><I><R><Q><Q><T><P><D><K><P><S><P><N><M><F><Y><I><D><P><E><K><G><D><I><V><T><V><V><S><P><A><L><L><D><R><E><T><L><E><N><P><K><Y><E><L><I><I><E><A><Q><D><M><A><G><L><D><V><G><L><T><G><T><A><T><A><T><I><M><I><D><D><K><N><D><H><S><P><K><F><T><K><K><E><F><Q><A><T><V><E><E><G><A><V><G><V><I><V><N><L><T><V><E><D><K><D><D><P><T><T><G><A><W><R><A><A><Y><T><I><I><N><G><N><P><G><Q><S><F><E><I><H><T><N><P><Q><T><N><E><G><M><L><S><V><V><K><P><L><D><Y><E><I><S><A><F><H><T><L><L><I><K><V><E><N><E><D><P><L><V><P><D><V><S><Y><G><P><S><S><T><A><T><V><H><I><T><V><L><D><V><N><E><G><P><V><F><Y><P><D><P><M><M><V><T><R><Q><E><D><L><S><V><G><S><V><L><L><T><V><N><A><T><D><P><D><S><L><Q><H><Q><T><I><R><Y><S><V><Y><K><D><P><A><G><W><L><N><I><N><P><I><N><G><T><V><D><T><T><A><V><L><D><R><E><S><P><F><V><D><N><S><V><Y><T><A><L><F><L><A><I><D><S><G><N><P><P><A><T><G><T><G><T><L><L><I><T><L><E><D><V><N><D><N><A><P><F><I><Y><P><T><V><A><E><V><C><D><D><A><K><N><L><S><V><V><I><L><G><A><S><D><K><D><L><H><P><N><T><D><P><F><K><F><E><I><H><K><Q><A><V><P><D><K><V><W><K><I><S><K><I><N><N><T><H><A><L><V><S><L><L><Q><N><L><N><K><A><N><Y><N><L><P><I><M><V><T><D><S><G><K><P><P><M><T><N><I><T><D><L><R><V><Q><V><C><S><C><R><N><S><K><V><D><C><N><A><A><G><A><L><R><F><S><L><P><S><V><L><L><L><S><L><F><S><L><A><C><L>
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.<BOP>
P55290
Q9NYG5
APC11_HUMAN
Hepatocellular carcinoma-associated RING finger protein
Homo
<M><K><V><K><I><K><C><W><N><G><V><A><T><W><L><W><V><A><N><D><E><N><C><G><I><C><R><M><A><F><N><G><C><C><P><D><C><K><V><P><G><D><D><C><P><L><V><W><G><Q><C><S><H><C><F><H><M><H><C><I><L><K><W><L><H><A><Q><Q><V><Q><Q><H><C><P><M><C><R><Q><E><W><K><F><K><E>
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.<BOP>
Q9NYG5
Q96KD3
GAR1B_HUMAN
Testis development protein NYD-SP18
Homo
<M><L><S><S><F><P><H><R><K><T><W><R><K><S><K><K><T><V><K><V><T><R><S><Y><P><T><F><P><S><L><N><A><W><E><E><F><R><G><L><L><P><V><D><G><E><P><N><P><G><A><G><L><G><V><E><E><G><L><L><C><R><V><V><H><S><P><E><F><N><L><F><L><D><S><V><V><F><E><S><N><F><I><Q><V><K><R><G><R><N><W><R><D><V><Y><K><A><S><N><T><M><A><L><G><V><T><S><S><V><P><C><L><P><L><P><N><I><L><L><M><A><S><V><K><W><H><Q><G><Q><N><Q><T><W><N><R><P><S><I><A><P><N><I><F><L><K><R><I><L><P><L><R><F><V><E><L><Q><V><C><D><H><Y><Q><R><I><L><Q><L><R><T><V><T><E><K><I><Y><Y><L><K><L><H><P><D><H><P><E><T><V><F><H><F><W><I><R><L><V><Q><I><L><Q><K><G><L><S><I><T><T><K><D><P><R><I><L><V><T><H><C><L><V><P><K><N><C><S><S><P><S><G><D><S><K><L><V><Q><K><K><L><Q><A><S><Q><P><S><E><S><L><I><Q><L><M><T><K><G><E><S><E><A><L><S><Q><I><F><A><D><L><H><Q><Q><N><Q><L><S><F><R><S><S><R><K><V><E><T><N><K><N><S><S><G><K><D><S><S><R><E><D><S><I><P><C><T><C><D><L><R><W><R><A><S><F><T><Y><G><E><W><E><R><E><N><P><S><G><L><Q><P><L><S><L><L><S><T><L><A><A><S><T><G><P><Q><L><A><P><P><I><G><N><S><I>
RAB2B effector protein required for accurate acrosome formation and normal male fertility. In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation.<BOP>
Q96KD3
Q9P0N9
TBCD7_HUMAN
Cell migration-inducing protein 23
Homo
<M><T><E><D><S><Q><R><N><F><R><S><V><Y><Y><E><K><V><G><F><R><G><V><E><E><K><K><S><L><E><I><L><L><K><D><D><R><L><D><T><E><K><L><C><T><F><S><Q><R><F><P><L><P><S><M><Y><R><A><L><V><W><K><V><L><L><G><I><L><P><P><H><H><E><S><H><A><K><V><M><M><Y><R><K><E><Q><Y><L><D><V><L><H><A><L><K><V><V><R><F><V><S><D><A><T><P><Q><A><E><V><Y><L><R><M><Y><Q><L><E><S><G><K><L><P><R><S><P><S><F><P><L><E><P><D><D><E><V><F><L><A><I><A><K><A><M><E><E><M><V><E><D><S><V><D><C><Y><W><I><T><R><R><F><V><N><Q><L><N><T><K><Y><R><D><S><L><P><Q><L><P><K><A><F><E><Q><Y><L><N><L><E><D><G><R><L><L><T><H><L><R><M><C><S><A><A><P><K><L><P><Y><D><L><W><F><K><R><C><F><A><G><C><L><P><E><S><S><L><Q><R><V><W><D><K><V><V><S><G><S><C><K><I><L><V><F><V><A><V><E><I><L><L><T><F><K><I><K><V><M><A><L><N><S><A><E><K><I><T><K><F><L><E><N><I><P><Q><D><S><S><D><A><I><V><S><K><A><I><D><L><W><H><K><H><C><G><T><P><V><H><S><S>
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<BOP>
Q9P0N9
P40227
TCPZ_HUMAN
Tcp20
Homo
<M><A><A><V><K><T><L><N><P><K><A><E><V><A><R><A><Q><A><A><L><A><V><N><I><S><A><A><R><G><L><Q><D><V><L><R><T><N><L><G><P><K><G><T><M><K><M><L><V><S><G><A><G><D><I><K><L><T><K><D><G><N><V><L><L><H><E><M><Q><I><Q><H><P><T><A><S><L><I><A><K><V><A><T><A><Q><D><D><I><T><G><D><G><T><T><S><N><V><L><I><I><G><E><L><L><K><Q><A><D><L><Y><I><S><E><G><L><H><P><R><I><I><T><E><G><F><E><A><A><K><E><K><A><L><Q><F><L><E><E><V><K><V><S><R><E><M><D><R><E><T><L><I><D><V><A><R><T><S><L><R><T><K><V><H><A><E><L><A><D><V><L><T><E><A><V><V><D><S><I><L><A><I><K><K><Q><D><E><P><I><D><L><F><M><I><E><I><M><E><M><K><H><K><S><E><T><D><T><S><L><I><R><G><L><V><L><D><H><G><A><R><H><P><D><M><K><K><R><V><E><D><A><Y><I><L><T><C><N><V><S><L><E><Y><E><K><T><E><V><N><S><G><F><F><Y><K><S><A><E><E><R><E><K><L><V><K><A><E><R><K><F><I><E><D><R><V><K><K><I><I><E><L><K><R><K><V><C><G><D><S><D><K><G><F><V><V><I><N><Q><K><G><I><D><P><F><S><L><D><A><L><S><K><E><G><I><V><A><L><R><R><A><K><R><R><N><M><E><R><L><T><L><A><C><G><G><V><A><L><N><S><F><D><D><L><S><P><D><C><L><G><H><A><G><L><V><Y><E><Y><T><L><G><E><E><K><F><T><F><I><E><K><C><N><N><P><R><S><V><T><L><L><I><K><G><P><N><K><H><T><L><T><Q><I><K><D><A><V><R><D><G><L><R><A><V><K><N><A><I><D><D><G><C><V><V><P><G><A><G><A><V><E><V><A><M><A><E><A><L><I><K><H><K><P><S><V><K><G><R><A><Q><L><G><V><Q><A><F><A><D><A><L><L><I><I><P><K><V><L><A><Q><N><S><G><F><D><L><Q><E><T><L><V><K><I><Q><A><E><H><S><E><S><G><Q><L><V><G><V><D><L><N><T><G><E><P><M><V><A><A><E><V><G><V><W><D><N><Y><C><V><K><K><Q><L><L><H><S><C><T><V><I><A><T><N><I><L><L><V><D><E><I><M><R><A><G><M><S><S><L><K><G>
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis . The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance . The TRiC complex plays a role in the folding of actin and tubulin (Probable).<BOP>
P40227
O00244
ATOX1_HUMAN
Metal transport protein ATX1
Homo
<M><P><K><H><E><F><S><V><D><M><T><C><G><G><C><A><E><A><V><S><R><V><L><N><K><L><G><G><V><K><Y><D><I><D><L><P><N><K><K><V><C><I><E><S><E><H><S><M><D><T><L><L><A><T><L><K><K><T><G><K><T><V><S><Y><L><G><L><E>
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.<BOP>
O00244
P51965
UB2E1_HUMAN
Ubiquitin-protein ligase E1
Homo
<M><S><D><D><D><S><R><A><S><T><S><S><S><S><S><S><S><S><N><Q><Q><T><E><K><E><T><N><T><P><K><K><K><E><S><K><V><S><M><S><K><N><S><K><L><L><S><T><S><A><K><R><I><Q><K><E><L><A><D><I><T><L><D><P><P><P><N><C><S><A><G><P><K><G><D><N><I><Y><E><W><R><S><T><I><L><G><P><P><G><S><V><Y><E><G><G><V><F><F><L><D><I><T><F><T><P><E><Y><P><F><K><P><P><K><V><T><F><R><T><R><I><Y><H><C><N><I><N><S><Q><G><V><I><C><L><D><I><L><K><D><N><W><S><P><A><L><T><I><S><K><V><L><L><S><I><C><S><L><L><T><D><C><N><P><A><D><P><L><V><G><S><I><A><T><Q><Y><M><T><N><R><A><E><H><D><R><M><A><R><Q><W><T><K><R><Y><A><T>
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.<BOP>
P51965
Q00169
PIPNA_HUMAN
Phosphatidylinositol transfer protein alpha isoform
Homo
<M><V><L><L><K><E><Y><R><V><I><L><P><V><S><V><D><E><Y><Q><V><G><Q><L><Y><S><V><A><E><A><S><K><N><E><T><G><G><G><E><G><V><E><V><L><V><N><E><P><Y><E><K><D><G><E><K><G><Q><Y><T><H><K><I><Y><H><L><Q><S><K><V><P><T><F><V><R><M><L><A><P><E><G><A><L><N><I><H><E><K><A><W><N><A><Y><P><Y><C><R><T><V><I><T><N><E><Y><M><K><E><D><F><L><I><K><I><E><T><W><H><K><P><D><L><G><T><Q><E><N><V><H><K><L><E><P><E><A><W><K><H><V><E><A><V><Y><I><D><I><A><D><R><S><Q><V><L><S><K><D><Y><K><A><E><E><D><P><A><K><F><K><S><I><K><T><G><R><G><P><L><G><P><N><W><K><Q><E><L><V><N><Q><K><D><C><P><Y><M><C><A><Y><K><L><V><T><V><K><F><K><W><W><G><L><Q><N><K><V><E><N><F><I><H><K><Q><E><R><R><L><F><T><N><F><H><R><Q><L><F><C><W><L><D><K><W><V><D><L><T><M><D><D><I><R><R><M><E><E><E><T><K><R><Q><L><D><E><M><R><Q><K><D><P><V><K><G><M><T><A><D><D>
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes . Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions . Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 .<BOP>
Q00169
O60921
HUS1_HUMAN
Checkpoint protein HUS1
Homo
<M><K><F><R><A><K><I><V><D><G><A><C><L><N><H><F><T><R><I><S><N><M><I><A><K><L><A><K><T><C><T><L><R><I><S><P><D><K><L><N><F><I><L><C><D><K><L><A><N><G><G><V><S><M><W><C><E><L><E><Q><E><N><F><F><N><E><F><Q><M><E><G><V><S><A><E><N><N><E><I><Y><L><E><L><T><S><E><N><L><S><R><A><L><K><T><A><Q><N><A><R><A><L><K><I><K><L><T><N><K><H><F><P><C><L><T><V><S><V><E><L><L><S><M><S><S><S><S><R><I><V><T><H><D><I><P><I><K><V><I><P><R><K><L><W><K><D><L><Q><E><P><V><V><P><D><P><D><V><S><I><Y><L><P><V><L><K><T><M><K><S><V><V><E><K><M><K><N><I><S><N><H><L><V><I><E><A><N><L><D><G><E><L><N><L><K><I><E><T><E><L><V><C><V><T><T><H><F><K><D><L><G><N><P><P><L><A><S><E><S><T><H><E><D><R><N><V><E><H><M><A><E><V><H><I><D><I><R><K><L><L><Q><F><L><A><G><Q><Q><V><N><P><T><K><A><L><C><N><I><V><N><N><K><M><V><H><F><D><L><L><H><E><D><V><S><L><Q><Y><F><I><P><A><L><S>
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.<BOP>
O60921
P56746
CLD15_HUMAN
Claudin-15
Homo
<M><S><M><A><V><E><T><F><G><F><F><M><A><T><V><G><L><L><M><L><G><V><T><L><P><N><S><Y><W><R><V><S><T><V><H><G><N><V><I><T><T><N><T><I><F><E><N><L><W><F><S><C><A><T><D><S><L><G><V><Y><N><C><W><E><F><P><S><M><L><A><L><S><G><Y><I><Q><A><C><R><A><L><M><I><T><A><I><L><L><G><F><L><G><L><L><L><G><I><A><G><L><R><C><T><N><I><G><G><L><E><L><S><R><K><A><K><L><A><A><T><A><G><A><L><H><I><L><A><G><I><C><G><M><V><A><I><S><W><Y><A><F><N><I><T><R><D><F><F><D><P><L><Y><P><G><T><K><Y><E><L><G><P><A><L><Y><L><G><W><S><A><S><L><I><S><I><L><G><G><L><C><L><C><S><A><C><C><C><G><S><D><E><D><P><A><A><S><A><R><R><P><Y><Q><A><P><V><S><V><M><P><V><A><T><S><D><Q><E><G><D><S><S><F><G><K><Y><G><R><N><A><Y><V>
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.<BOP>
P56746
Q9NR20
DYRK4_HUMAN
Dual specificity tyrosine-phosphorylation-regulated kinase 4
Homo
<M><P><A><S><E><L><K><A><S><E><I><P><F><H><P><S><I><K><T><Q><D><P><K><A><E><E><K><S><P><K><K><Q><K><V><T><L><T><A><A><E><A><L><K><L><F><K><N><Q><L><S><P><Y><E><Q><S><E><I><L><G><Y><A><E><L><W><F><L><G><L><E><A><K><K><L><D><T><A><P><E><K><F><S><K><T><S><F><D><D><E><H><G><F><Y><L><K><V><L><H><D><H><I><A><Y><R><Y><E><V><L><E><T><I><G><K><G><S><F><G><Q><V><A><K><C><L><D><H><K><N><N><E><L><V><A><L><K><I><I><R><N><K><K><R><F><H><Q><Q><A><L><M><E><L><K><I><L><E><A><L><R><K><K><D><K><D><N><T><Y><N><V><V><H><M><K><D><F><F><Y><F><R><N><H><F><C><I><T><F><E><L><L><G><I><N><L><Y><E><L><M><K><N><N><N><F><Q><G><F><S><L><S><I><V><R><R><F><T><L><S><V><L><K><C><L><Q><M><L><S><V><E><K><I><I><H><C><D><L><K><P><E><N><I><V><L><Y><Q><K><G><Q><A><S><V><K><V><I><D><F><G><S><S><C><Y><E><H><Q><K><V><Y><T><Y><I><Q><S><R><F><Y><R><S><P><E><V><I><L><G><H><P><Y><D><V><A><I><D><M><W><S><L><G><C><I><T><A><E><L><Y><T><G><Y><P><L><F><P><G><E><N><E><V><E><Q><L><A><C><I><M><E><V><L><G><L><P><P><A><G><F><I><Q><T><A><S><R><R><Q><T><F><F><D><S><K><G><F><P><K><N><I><T><N><N><R><G><K><K><R><Y><P><D><S><K><D><L><T><M><V><L><K><T><Y><D><T><S><F><L><D><F><L><R><R><C><L><V><W><E><P><S><L><R><M><T><P><D><Q><A><L><K><H><A><W><I><H><Q><S><R><N><L><K><P><Q><P><R><P><Q><T><L><R><K><S><N><S><F><F><P><S><E><T><R><K><D><K><V><Q><G><C><H><H><S><S><R><K><A><D><E><I><T><K><E><T><T><E><K><T><K><D><S><P><T><K><H><V><Q><H><S><G><D><Q><Q><D><C><L><Q><H><G><A><D><T><V><Q><L><P><Q><L><V><D><A><P><K><K><S><E><A><A><V><G><A><E><V><S><M><T><S><P><G><Q><S><K><N><F><S><L><K><N><T><N><V><L><P><P><I><V>
Possible non-essential role in spermiogenesis.<BOP>
Q9NR20
Q13416
ORC2_HUMAN
Origin recognition complex subunit 2
Homo
<M><S><K><P><E><L><K><E><D><K><M><L><E><V><H><F><V><G><D><D><D><V><L><N><H><I><L><D><R><E><G><G><A><K><L><K><K><E><R><A><Q><L><L><V><N><P><K><K><I><I><K><K><P><E><Y><D><L><E><E><D><D><Q><E><V><L><K><D><Q><N><Y><V><E><I><M><G><R><D><V><Q><E><S><L><K><N><G><S><A><T><G><G><G><N><K><V><Y><S><F><Q><N><R><K><H><S><E><K><M><A><K><L><A><S><E><L><A><K><T><P><Q><K><S><V><S><F><S><L><K><N><D><P><E><I><T><I><N><V><P><Q><S><S><K><G><H><S><A><S><D><K><V><Q><P><K><N><N><D><K><S><E><F><L><S><T><A><P><R><S><L><R><K><R><L><I><V><P><R><S><H><S><D><S><E><S><E><Y><S><A><S><N><S><E><D><D><E><G><V><A><Q><E><H><E><E><D><T><N><A><V><I><F><S><Q><K><I><Q><A><Q><N><R><V><V><S><A><P><V><G><K><E><T><P><S><K><R><M><K><R><D><K><T><S><D><L><V><E><E><Y><F><E><A><H><S><S><S><K><V><L><T><S><D><R><T><L><Q><K><L><K><R><A><K><L><D><Q><Q><T><L><R><N><L><L><S><K><V><S><P><S><F><S><A><E><L><K><Q><L><N><Q><Q><Y><E><K><L><F><H><K><W><M><L><Q><L><H><L><G><F><N><I><V><L><Y><G><L><G><S><K><R><D><L><L><E><R><F><R><T><T><M><L><Q><D><S><I><H><V><V><I><N><G><F><F><P><G><I><S><V><K><S><V><L><N><S><I><T><E><E><V><L><D><H><M><G><T><F><R><S><I><L><D><Q><L><D><W><I><V><N><K><F><K><E><D><S><S><L><E><L><F><L><L><I><H><N><L><D><S><Q><M><L><R><G><E><K><S><Q><Q><I><I><G><Q><L><S><S><L><H><N><I><Y><L><I><A><S><I><D><H><L><N><A><P><L><M><W><D><H><A><K><Q><S><L><F><N><W><L><W><Y><E><T><T><T><Y><S><P><Y><T><E><E><T><S><Y><E><N><S><L><L><V><K><Q><S><G><S><L><P><L><S><S><L><T><H><V><L><R><S><L><T><P><N><A><R><G><I><F><R><L><L><I><K><Y><Q><L><D><N><Q><D><N><P><S><Y><I><G><L><S><F><Q><D><F><Y><Q><Q><C><R><E><A><F><L><V><N><S><D><L><T><L><R><A><Q><L><T><E><F><R><D><H><K><L><I><R><T><K><K><G><T><D><G><V><E><Y><L><L><I><P><V><D><N><G><T><L><T><D><F><L><E><K><E><E><E><E><A>
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.<BOP>
Q13416
Q5F1R6
DJC21_HUMAN
Protein GS3
Homo
<M><K><C><H><Y><E><A><L><G><V><R><R><D><A><S><E><E><E><L><K><K><A><Y><R><K><L><A><L><K><W><H><P><D><K><N><L><D><N><A><A><E><A><A><E><Q><F><K><L><I><Q><A><A><Y><D><V><L><S><D><P><Q><E><R><A><W><Y><D><N><H><R><E><A><L><L><K><G><G><F><D><G><E><Y><Q><D><D><S><L><D><L><L><R><Y><F><T><V><T><C><Y><S><G><Y><G><D><D><E><K><G><F><Y><T><V><Y><R><N><V><F><E><M><I><A><K><E><E><L><E><S><V><L><E><E><E><V><D><D><F><P><T><F><G><D><S><Q><S><D><Y><D><T><V><V><H><P><F><Y><A><Y><W><Q><S><F><C><T><Q><K><N><F><A><W><K><E><E><Y><D><T><R><Q><A><S><N><R><W><E><K><R><A><M><E><K><E><N><K><K><I><R><D><K><A><R><K><E><K><N><E><L><V><R><Q><L><V><A><F><I><R><K><R><D><K><R><V><Q><A><H><R><K><L><V><E><E><Q><N><A><E><K><A><R><K><A><E><E><M><R><R><Q><Q><K><L><K><Q><A><K><L><V><E><Q><Y><R><E><Q><S><W><M><T><M><A><N><L><E><K><E><L><Q><E><M><E><A><R><Y><E><K><E><F><G><D><G><S><D><E><N><E><M><E><E><H><E><L><K><D><E><E><D><G><K><D><S><D><E><A><E><D><A><E><L><Y><D><D><L><Y><C><P><A><C><D><K><S><F><K><T><E><K><A><M><K><N><H><E><K><S><K><K><H><R><E><M><V><A><L><L><K><Q><Q><L><E><E><E><E><E><N><F><S><R><P><Q><I><D><E><N><P><L><D><D><N><S><E><E><E><M><E><D><A><P><K><Q><K><L><S><K><K><Q><K><K><K><K><Q><K><P><A><Q><N><Y><D><D><N><F><N><V><N><G><P><G><E><G><V><K><V><D><P><E><D><T><N><L><N><Q><D><S><A><K><E><L><E><D><S><P><Q><E><N><V><S><V><T><E><I><I><K><P><C><D><D><P><K><S><E><A><K><S><V><P><K><P><K><G><K><K><T><K><D><M><K><K><P><V><R><V><P><A><E><P><Q><T><M><S><V><L><I><S><C><T><T><C><H><S><E><F><P><S><R><N><K><L><F><D><H><L><K><A><T><G><H><A><R><A><P><S><S><S><S><L><N><S><A><T><S><S><Q><S><K><K><E><K><R><K><N><R>
May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA.<BOP>
Q5F1R6
Q96D31
CRCM1_HUMAN
Transmembrane protein 142A
Homo
<M><H><P><E><P><A><P><P><P><S><R><S><S><P><E><L><P><P><S><G><G><S><T><T><S><G><S><R><R><S><R><R><R><S><G><D><G><E><P><P><G><A><P><P><P><P><P><S><A><V><T><Y><P><D><W><I><G><Q><S><Y><S><E><V><M><S><L><N><E><H><S><M><Q><A><L><S><W><R><K><L><Y><L><S><R><A><K><L><K><A><S><S><R><T><S><A><L><L><S><G><F><A><M><V><A><M><V><E><V><Q><L><D><A><D><H><D><Y><P><P><G><L><L><I><A><F><S><A><C><T><T><V><L><V><A><V><H><L><F><A><L><M><I><S><T><C><I><L><P><N><I><E><A><V><S><N><V><H><N><L><N><S><V><K><E><S><P><H><E><R><M><H><R><H><I><E><L><A><W><A><F><S><T><V><I><G><T><L><L><F><L><A><E><V><V><L><L><C><W><V><K><F><L><P><L><K><K><Q><P><G><Q><P><R><P><T><S><K><P><P><A><S><G><A><A><A><N><V><S><T><S><G><I><T><P><G><Q><A><A><A><I><A><S><T><T><I><M><V><P><F><G><L><I><F><I><V><F><A><V><H><F><Y><R><S><L><V><S><H><K><T><D><R><Q><F><Q><E><L><N><E><L><A><E><F><A><R><L><Q><D><Q><L><D><H><R><G><D><H><P><L><T><P><G><S><H><Y><A>
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 . CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT . Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion.<BOP>
Q96D31
Q9Y3P8
SIT1_HUMAN
gp30/40
Homo
<M><N><Q><A><D><P><R><L><R><A><V><C><L><W><T><L><T><S><A><A><M><S><R><G><D><N><C><T><D><L><L><A><L><G><I><P><S><I><T><Q><A><W><G><L><W><V><L><L><G><A><V><T><L><L><F><L><I><S><L><A><A><H><L><S><Q><W><T><R><G><R><S><R><S><H><P><G><Q><G><R><S><G><E><S><V><E><E><V><P><L><Y><G><N><L><H><Y><L><Q><T><G><R><L><S><Q><D><P><E><P><D><Q><Q><D><P><T><L><G><G><P><A><R><A><A><E><E><V><M><C><Y><T><S><L><Q><L><R><P><P><Q><G><R><I><P><G><P><G><T><P><V><K><Y><S><E><V><V><L><D><S><E><P><K><S><Q><A><S><G><P><E><P><E><L><Y><A><S><V><C><A><Q><T><R><R><A><R><A><S><F><P><D><Q><A><Y><A><N><S><Q><P><A><A><S>
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.<BOP>
Q9Y3P8
P49862
KLK7_HUMAN
Stratum corneum chymotryptic enzyme
Homo
<M><A><R><S><L><L><L><P><L><Q><I><L><L><L><S><L><A><L><E><T><A><G><E><E><A><Q><G><D><K><I><I><D><G><A><P><C><A><R><G><S><H><P><W><Q><V><A><L><L><S><G><N><Q><L><H><C><G><G><V><L><V><N><E><R><W><V><L><T><A><A><H><C><K><M><N><E><Y><T><V><H><L><G><S><D><T><L><G><D><R><R><A><Q><R><I><K><A><S><K><S><F><R><H><P><G><Y><S><T><Q><T><H><V><N><D><L><M><L><V><K><L><N><S><Q><A><R><L><S><S><M><V><K><K><V><R><L><P><S><R><C><E><P><P><G><T><T><C><T><V><S><G><W><G><T><T><T><S><P><D><V><T><F><P><S><D><L><M><C><V><D><V><K><L><I><S><P><Q><D><C><T><K><V><Y><K><D><L><L><E><N><S><M><L><C><A><G><I><P><D><S><K><K><N><A><C><N><G><D><S><G><G><P><L><V><C><R><G><T><L><Q><G><L><V><S><W><G><T><F><P><C><G><Q><P><N><D><P><G><V><Y><T><Q><V><C><K><F><T><K><W><I><N><D><T><M><K><K><H><R>
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.<BOP>
P49862
Q9UNZ5
L10K_HUMAN
Leydig cell tumor 10 kDa protein homolog
Homo
<M><A><Q><G><Q><R><K><F><Q><A><H><K><P><A><K><S><K><T><A><A><A><A><S><E><K><N><R><G><P><R><K><G><G><R><V><I><A><P><K><K><A><R><V><V><Q><Q><Q><K><L><K><K><N><L><E><V><G><I><R><K><K><I><E><H><D><V><V><M><K><A><S><S><S><L><P><K><K><L><A><L><L><K><A><P><A><K><K><K><G><A><A><A><A><T><S><S><K><T><P><S>
May have a potential role in hypercalcemia of malignancy.<BOP>
Q9UNZ5
Q8NGG0
OR8J3_HUMAN
Olfactory receptor OR11-173
Homo
<M><A><P><E><N><F><T><R><V><T><E><F><I><L><T><G><V><S><S><C><P><E><L><Q><I><P><L><F><L><V><F><L><V><L><Y><V><L><T><M><A><G><N><L><G><I><I><T><L><T><S><V><D><S><R><L><Q><N><P><M><Y><F><F><L><R><H><L><A><I><I><N><L><G><N><S><T><V><I><A><P><K><M><L><M><N><F><L><V><K><K><K><T><T><S><F><Y><E><C><A><T><Q><L><G><G><F><L><F><F><I><V><S><E><V><M><M><L><A><V><M><A><Y><D><R><Y><V><A><I><C><N><P><L><L><Y><M><V><V><V><S><R><R><L><C><L><L><L><V><S><L><T><Y><L><Y><G><F><S><T><A><I><V><V><S><P><C><I><F><S><V><S><Y><C><S><S><N><I><I><N><H><F><Y><C><D><I><A><P><L><L><A><L><S><C><S><D><T><Y><I><P><E><T><I><V><F><I><S><A><A><T><N><L><V><F><S><M><I><T><V><L><V><S><Y><F><N><I><V><L><S><I><L><R><I><R><S><P><E><G><R><K><K><A><F><S><T><C><A><S><H><M><I><A><V><T><V><F><Y><G><T><M><L><F><M><Y><L><Q><P><Q><T><N><H><S><L><D><T><D><K><M><A><S><V><F><Y><T><L><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><N><D><V><N><V><A><L><K><K><F><M><E><N><P><C><Y><S><F><K><S><M>
Odorant receptor.<BOP>
Q8NGG0
Q9HB40
RISC_HUMAN
Serine carboxypeptidase 1
Homo
<M><E><L><A><L><R><R><S><P><V><P><R><W><L><L><L><L><P><L><L><L><G><L><N><A><G><A><V><I><D><W><P><T><E><E><G><K><E><V><W><D><Y><V><T><V><R><K><D><A><Y><M><F><W><W><L><Y><Y><A><T><N><S><C><K><N><F><S><E><L><P><L><V><M><W><L><Q><G><G><P><G><G><S><S><T><G><F><G><N><F><E><E><I><G><P><L><D><S><D><L><K><P><R><K><T><T><W><L><Q><A><A><S><L><L><F><V><D><N><P><V><G><T><G><F><S><Y><V><N><G><S><G><A><Y><A><K><D><L><A><M><V><A><S><D><M><M><V><L><L><K><T><F><F><S><C><H><K><E><F><Q><T><V><P><F><Y><I><F><S><E><S><Y><G><G><K><M><A><A><G><I><G><L><E><L><Y><K><A><I><Q><R><G><T><I><K><C><N><F><A><G><V><A><L><G><D><S><W><I><S><P><V><D><S><V><L><S><W><G><P><Y><L><Y><S><M><S><L><L><E><D><K><G><L><A><E><V><S><K><V><A><E><Q><V><L><N><A><V><N><K><G><L><Y><R><E><A><T><E><L><W><G><K><A><E><M><I><I><E><Q><N><T><D><G><V><N><F><Y><N><I><L><T><K><S><T><P><T><S><T><M><E><S><S><L><E><F><T><Q><S><H><L><V><C><L><C><Q><R><H><V><R><H><L><Q><R><D><A><L><S><Q><L><M><N><G><P><I><R><K><K><L><K><I><I><P><E><D><Q><S><W><G><G><Q><A><T><N><V><F><V><N><M><E><E><D><F><M><K><P><V><I><S><I><V><D><E><L><L><E><A><G><I><N><V><T><V><Y><N><G><Q><L><D><L><I><V><D><T><M><G><Q><E><A><W><V><R><K><L><K><W><P><E><L><P><K><F><S><Q><L><K><W><K><A><L><Y><S><D><P><K><S><L><E><T><S><A><F><V><K><S><Y><K><N><L><A><F><Y><W><I><L><K><A><G><H><M><V><P><S><D><Q><G><D><M><A><L><K><M><M><R><L><V><T><Q><Q><E>
May be involved in vascular wall and kidney homeostasis.<BOP>
Q9HB40
Q3MIS6
ZN528_HUMAN
Zinc finger protein 528
Homo
<M><A><L><T><Q><G><P><L><K><F><M><D><V><A><I><E><F><S><Q><E><E><W><K><C><L><D><P><A><Q><R><T><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><G><I><C><L><P><D><L><S><V><T><S><M><L><E><Q><K><R><D><P><W><T><L><Q><S><E><E><K><I><A><N><D><P><D><G><R><E><C><I><K><G><V><N><T><E><R><S><S><K><L><G><S><N><A><G><N><K><P><C><K><N><Q><L><G><F><T><F><Q><L><H><L><S><D><L><Q><L><F><Q><A><E><R><K><I><S><G><C><K><H><F><E><K><P><V><S><D><N><S><S><V><S><P><L><E><K><I><S><S><S><V><K><S><H><L><L><N><K><Y><R><N><N><F><D><H><A><P><L><L><P><Q><E><Q><K><A><H><I><R><E><K><A><Y><K><C><N><E><H><G><Q><V><F><R><A><S><A><S><L><T><N><Q><V><I><H><N><A><D><N><P><Y><K><C><S><E><C><G><K><V><F><S><C><S><S><K><L><V><I><H><R><R><M><H><T><G><E><K><P><Y><K><C><H><E><C><G><K><L><F><S><S><N><S><N><L><S><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><H><E><C><D><K><V><F><R><S><S><S><K><L><A><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><H><E><C><D><K><V><F><N><Q><I><A><H><L><V><R><H><Q><K><I><H><T><G><E><K><P><Y><S><C><N><K><C><G><K><V><F><S><R><H><S><Y><L><A><E><H><Q><T><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><S><V><R><S><S><L><I><T><H><Q><L><I><H><T><G><R><K><P><Y><K><C><K><E><C><D><K><V><F><G><R><K><C><F><L><T><S><H><Q><R><I><H><T><R><E><R><P><Y><G><C><S><Q><C><G><K><I><F><S><Q><K><S><D><L><I><R><H><R><K><T><H><T><D><E><K><P><Y><K><C><N><K><C><G><T><A><F><R><E><F><S><D><L><T><A><H><F><L><I><H><S><G><E><K><P><Y><E><C><K><E><C><G><K><V><F><R><Y><K><S><S><L><T><S><H><H><R><I><H><T><G><E><K><P><Y><K><C><N><R><C><G><K><V><F><S><R><S><S><N><L><V><C><H><Q><K><I><H><T><G><E><K><P><Y><K><C><N><Q><C><G><K><V><F><N><Q><A><S><Y><L><T><R><H><Q><I><I><H><T><G><E><R><P><Y><R><C><S><K><C><G><K><A><F><R><G><C><S><G><L><T><A><H><L><A><I><H><T><E><K><K><S><H><E><C><K><E><C><G><K><I><F><T><Q><K><S><S><L><T><N><H><H><R><I><H><I><G><E><K><P><Y><K><C><T><L><C><S><K><V><F><S><H><N><S><D><L><A><Q><H><Q><R><V><H><S>
May be involved in transcriptional regulation.<BOP>
Q3MIS6
A6NIH7
U119B_HUMAN
Protein unc-119 homolog B
Homo
<M><S><G><S><N><P><K><A><A><A><A><A><S><A><A><G><P><G><G><L><V><A><G><K><E><E><K><K><K><A><G><G><G><V><L><N><R><L><K><A><R><R><Q><A><P><H><H><A><A><D><D><G><V><G><A><A><V><T><E><Q><E><L><L><A><L><D><T><I><R><P><E><H><V><L><R><L><S><R><V><T><E><N><Y><L><C><K><P><E><D><N><I><Y><S><I><D><F><T><R><F><K><I><R><D><L><E><T><G><T><V><L><F><E><I><A><K><P><C><V><S><D><Q><E><E><D><E><E><E><G><G><G><D><V><D><I><S><A><G><R><F><V><R><Y><Q><F><T><P><A><F><L><R><L><R><T><V><G><A><T><V><E><F><T><V><G><D><K><P><V><S><N><F><R><M><I><E><R><H><Y><F><R><E><H><L><L><K><N><F><D><F><D><F><G><F><C><I><P><S><S><R><N><T><C><E><H><I><Y><E><F><P><Q><L><S><E><D><V><I><R><L><M><I><E><N><P><Y><E><T><R><S><D><S><F><Y><F><V><D><N><K><L><I><M><H><N><K><A><D><Y><A><Y><N><G><G><Q>
Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.<BOP>
A6NIH7
P11172
UMPS_HUMAN
OMPdecase
Homo
<M><A><V><A><R><A><A><L><G><P><L><V><T><G><L><Y><D><V><Q><A><F><K><F><G><D><F><V><L><K><S><G><L><S><S><P><I><Y><I><D><L><R><G><I><V><S><R><P><R><L><L><S><Q><V><A><D><I><L><F><Q><T><A><Q><N><A><G><I><S><F><D><T><V><C><G><V><P><Y><T><A><L><P><L><A><T><V><I><C><S><T><N><Q><I><P><M><L><I><R><R><K><E><T><K><D><Y><G><T><K><R><L><V><E><G><T><I><N><P><G><E><T><C><L><I><I><E><D><V><V><T><S><G><S><S><V><L><E><T><V><E><V><L><Q><K><E><G><L><K><V><T><D><A><I><V><L><L><D><R><E><Q><G><G><K><D><K><L><Q><A><H><G><I><R><L><H><S><V><C><T><L><S><K><M><L><E><I><L><E><Q><Q><K><K><V><D><A><E><T><V><G><R><V><K><R><F><I><Q><E><N><V><F><V><A><A><N><H><N><G><S><P><L><S><I><K><E><A><P><K><E><L><S><F><G><A><R><A><E><L><P><R><I><H><P><V><A><S><K><L><L><R><L><M><Q><K><K><E><T><N><L><C><L><S><A><D><V><S><L><A><R><E><L><L><Q><L><A><D><A><L><G><P><S><I><C><M><L><K><T><H><V><D><I><L><N><D><F><T><L><D><V><M><K><E><L><I><T><L><A><K><C><H><E><F><L><I><F><E><D><R><K><F><A><D><I><G><N><T><V><K><K><Q><Y><E><G><G><I><F><K><I><A><S><W><A><D><L><V><N><A><H><V><V><P><G><S><G><V><V><K><G><L><Q><E><V><G><L><P><L><H><R><G><C><L><L><I><A><E><M><S><S><T><G><S><L><A><T><G><D><Y><T><R><A><A><V><R><M><A><E><E><H><S><E><F><V><V><G><F><I><S><G><S><R><V><S><M><K><P><E><F><L><H><L><T><P><G><V><Q><L><E><A><G><G><D><N><L><G><Q><Q><Y><N><S><P><Q><E><V><I><G><K><R><G><S><D><I><I><I><V><G><R><G><I><I><S><A><A><D><R><L><E><A><A><E><M><Y><R><K><A><A><W><E><A><Y><L><S><R><L><G><V>
Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP).<BOP>
P11172
A6NIJ9
O6C70_HUMAN
Olfactory receptor 6C70
Homo
<M><K><N><H><T><R><Q><I><E><F><I><L><L><G><L><T><D><N><S><Q><L><Q><I><V><I><F><L><F><L><L><L><N><C><V><L><S><M><I><G><N><F><T><I><I><A><L><I><L><L><D><S><Q><L><K><T><P><M><Y><F><F><L><R><N><F><S><F><L><E><I><S><F><T><T><A><C><I><P><R><F><L><I><T><I><V><T><R><E><K><T><I><S><C><N><G><C><I><S><Q><L><F><F><Y><I><F><L><G><V><T><E><F><F><L><L><A><A><L><S><Y><D><R><Y><V><A><I><C><K><P><L><R><Y><M><S><I><M><S><N><K><V><C><Y><Q><L><V><F><S><S><W><V><T><G><F><L><I><I><F><T><P><L><I><L><G><L><N><L><D><F><C><A><S><N><I><I><D><H><F><I><C><D><I><S><L><I><L><Q><L><S><C><S><D><T><H><L><L><E><L><I><A><F><L><L><A><V><M><T><L><I><V><T><L><F><L><V><I><L><S><Y><S><Y><I><I><K><T><I><L><K><F><P><S><A><Q><Q><K><K><K><A><F><S><T><C><S><S><H><M><I><V><V><S><I><T><Y><G><S><C><M><F><I><Y><I><K><P><S><A><N><E><R><V><A><L><S><K><G><V><T><V><L><N><T><S><V><A><P><L><L><N><P><F><I><Y><T><L><R><N><Q><Q><V><K><Q><A><F><K><A><V><F><R><K><I><F><S><A><S><D><K>
Odorant receptor.<BOP>
A6NIJ9
Q14954
KI2S1_HUMAN
MHC class I NK cell receptor Eb6 ActI
Homo
<M><S><L><T><V><V><S><M><A><C><V><G><F><F><L><L><Q><G><A><W><P><H><E><G><V><H><R><K><P><S><L><L><A><H><P><G><R><L><V><K><S><E><E><T><V><I><L><Q><C><W><S><D><V><M><F><E><H><F><L><L><H><R><E><G><M><F><N><D><T><L><R><L><I><G><E><H><H><D><G><V><S><K><A><N><F><S><I><S><R><M><K><Q><D><L><A><G><T><Y><R><C><Y><G><S><V><T><H><S><P><Y><Q><L><S><A><P><S><D><P><L><D><I><V><I><I><G><L><Y><E><K><P><S><L><S><A><Q><P><G><P><T><V><L><A><G><E><N><V><T><L><S><C><S><S><R><S><S><Y><D><M><Y><H><L><S><R><E><G><E><A><H><E><R><R><L><P><A><G><T><K><V><N><G><T><F><Q><A><N><F><P><L><G><P><A><T><H><G><G><T><Y><R><C><F><G><S><F><R><D><S><P><Y><E><W><S><K><S><S><D><P><L><L><V><S><V><T><G><N><P><S><N><S><W><P><S><P><T><E><P><S><S><E><T><G><N><P><R><H><L><H><V><L><I><G><T><S><V><V><K><I><P><F><T><I><L><L><F><F><L><L><H><R><W><C><S><D><K><K><N><A><A><V><M><D><Q><E><P><A><G><N><R><T><V><N><S><E><D><S><D><E><Q><D><H><Q><E><V><S><Y><A>
Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells.<BOP>
Q14954
Q2M2E3
ODFP4_HUMAN
Testis-specific protein oppo 1
Homo
<M><D><A><E><Y><S><G><N><E><F><P><R><S><E><G><E><R><D><Q><H><Q><R><P><G><K><E><R><K><S><G><E><A><G><W><G><T><G><E><L><G><Q><D><G><R><L><L><S><S><T><L><S><L><S><S><N><R><S><L><G><Q><R><Q><N><S><P><L><P><F><Q><W><R><I><T><H><S><F><R><W><M><A><Q><V><L><A><S><E><L><S><L><V><A><F><I><L><L><L><V><V><A><F><S><K><K><W><L><D><L><S><R><S><L><F><Y><Q><R><W><P><V><D><V><S><N><R><I><H><T><S><A><H><V><M><S><M><G><L><L><H><F><Y><K><S><R><S><C><S><D><L><E><N><G><K><V><T><F><I><F><S><T><L><M><L><F><P><I><N><I><W><I><F><E><L><E><R><N><V><S><I><P><I><G><W><S><Y><F><I><G><W><L><V><L><I><L><Y><F><T><C><A><I><L><C><Y><F><N><H><K><S><F><W><S><L><I><L><S><H><P><S><G><A><V><S><C><S><S><S><F><G><S><V><E><E><S><P><R><A><Q><T><I><T><D><T><P><I><T><Q><E><G><V><L><D><P><E><Q><K><D><T><H><V>
Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.<BOP>
Q2M2E3
Q9BQY9
DBND2_HUMAN
HSMNP1
Homo
<M><G><A><G><N><F><L><T><A><L><E><V><P><V><A><A><L><A><G><A><A><S><D><R><R><A><S><C><E><R><V><S><P><P><P><P><L><P><H><F><R><L><P><P><L><P><R><S><R><L><P><G><P><V><S><R><P><E><P><G><A><P><L><L><G><C><W><L><Q><W><G><A><P><S><P><G><P><L><C><L><L><F><R><L><C><S><C><T><C><F><A><P><L><P><A><G><A><D><M><D><P><N><P><R><A><A><L><E><R><Q><Q><L><R><L><R><E><R><Q><K><F><F><E><D><I><L><Q><P><E><T><E><F><V><F><P><L><S><H><L><H><L><E><S><Q><R><P><P><I><G><S><I><S><S><M><E><V><N><V><D><T><L><E><Q><V><E><L><I><D><L><G><D><P><D><A><A><D><V><F><L><P><C><E><D><P><P><P><T><P><Q><S><S><G><M><D><N><H><L><E><E><L><S><L><P><V><P><T><S><D><R><T><T><S><R><T><S><S><S><S><S><S><D><S><S><T><N><L><H><S><P><N><P><S><D><D><G><A><D><T><P><L><A><Q><S><D><E><E><E><E><R><G><D><G><G><A><E><P><G><A><C><S>
May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).<BOP>
Q9BQY9
Q9ULW6
NP1L2_HUMAN
Brain-specific protein, X-linked
Homo
<M><A><E><S><E><N><R><K><E><L><S><E><S><S><Q><E><E><A><G><N><Q><I><M><V><E><G><L><G><E><H><L><E><R><G><E><D><A><A><A><G><L><G><D><D><G><K><C><G><E><E><A><A><A><G><L><G><E><E><G><E><N><G><E><D><T><A><A><G><S><G><E><D><G><K><K><G><G><D><T><D><E><D><S><E><A><D><R><P><K><G><L><I><G><Y><V><L><D><T><D><F><V><E><S><L><P><V><K><V><K><Y><R><V><L><A><L><K><K><L><Q><T><R><A><A><N><L><E><S><K><F><L><R><E><F><H><D><I><E><R><K><F><A><E><M><Y><Q><P><L><L><E><K><R><R><Q><I><I><N><A><I><Y><E><P><T><E><E><E><C><E><Y><K><S><D><S><E><D><C><D><D><E><E><M><C><H><E><E><M><Y><G><N><E><E><G><M><V><H><E><Y><V><D><E><D><D><G><Y><E><D><Y><Y><Y><D><Y><A><V><E><E><E><E><E><E><E><E><E><D><D><I><E><A><T><G><E><E><N><K><E><E><E><D><P><K><G><I><P><D><F><W><L><T><V><L><K><N><V><D><T><L><T><P><L><I><K><K><Y><D><E><P><I><L><K><L><L><T><D><I><K><V><K><L><S><D><P><G><E><P><L><S><F><T><L><E><F><H><F><K><P><N><E><Y><F><K><N><E><L><L><T><K><T><Y><V><L><K><S><K><L><A><Y><Y><D><P><H><P><Y><R><G><T><A><I><E><Y><S><T><G><C><E><I><D><W><N><E><G><K><N><V><T><L><K><T><I><K><K><K><Q><K><H><R><I><W><G><T><I><R><T><V><T><E><D><F><P><K><D><S><F><F><N><F><F><S><P><H><G><I><T><S><N><G><R><D><G><N><D><D><F><L><L><G><H><N><L><R><T><Y><I><I><P><R><S><V><L><F><F><S><G><D><A><L><E><S><Q><Q><E><G><V><V><R><E><V><N><D><A><I><Y><D><K><I><I><Y><D><N><W><M><A><A><I><E><E><V><K><A><C><C><K><N><L><E><A><L><V><E><D><I><D><R>
Acidic protein which may be involved in interactions with other proteins or DNA.<BOP>
Q9ULW6
Q8N9F8
ZN454_HUMAN
Zinc finger protein 454
Homo
<M><A><V><S><H><L><P><T><M><V><Q><E><S><V><T><F><K><D><V><A><I><L><F><T><Q><E><E><W><G><Q><L><S><P><A><Q><R><A><L><Y><R><D><V><M><L><E><N><Y><S><N><L><V><S><L><G><L><L><G><P><K><P><D><T><F><S><Q><L><E><K><R><E><V><W><M><P><E><D><T><P><G><G><F><C><L><D><W><M><T><M><P><A><S><K><K><S><T><V><K><A><E><I><P><E><E><E><L><D><Q><W><T><I><K><E><R><F><S><S><S><S><H><W><K><C><A><S><L><L><E><W><Q><C><G><G><Q><E><I><S><L><Q><R><V><V><L><T><H><P><N><T><P><S><Q><E><C><D><E><S><G><S><T><M><S><S><S><L><H><S><D><Q><S><Q><G><F><Q><P><S><K><N><A><F><E><C><S><E><C><G><K><V><F><S><K><S><S><T><L><N><K><H><Q><K><I><H><N><E><K><N><A><N><Q><K><I><H><I><K><E><K><R><Y><E><C><R><E><C><G><K><A><F><H><Q><S><T><H><L><I><H><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><V><S><S><S><L><T><Y><H><Q><K><I><H><T><G><E><K><P><F><E><C><N><L><C><G><K><A><F><I><R><N><I><H><L><A><H><H><H><R><I><H><T><G><E><K><P><F><K><C><N><I><C><E><K><A><F><V><C><R><A><H><L><T><K><H><Q><N><I><H><S><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><N><Q><S><T><S><F><L><Q><H><Q><R><I><H><T><G><E><K><P><F><E><C><N><E><C><G><K><A><F><R><V><N><S><S><L><T><E><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><R><D><N><S><S><F><A><R><H><R><K><I><H><T><G><E><K><P><Y><R><C><G><L><C><E><K><A><F><R><D><Q><S><A><L><A><Q><H><Q><R><I><H><T><G><E><K><P><Y><T><C><N><I><C><E><K><A><F><S><D><H><S><A><L><T><Q><H><K><R><I><H><T><R><E><K><P><Y><K><C><K><I><C><E><K><A><F><I><R><S><T><H><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><K><C><G><K><A><F><N><Q><T><A><N><L><I><Q><H><Q><R><H><H><I><G><E><K>
May be involved in transcriptional regulation.<BOP>
Q8N9F8
Q3ZCQ2
AX2R_HUMAN
Annexin II receptor
Homo
<M><E><Q><H><F><L><G><C><V><K><R><A><W><D><S><A><E><V><A><P><E><P><Q><P><P><P><I><V><S><S><E><D><R><G><P><W><P><L><P><L><Y><P><V><L><G><E><Y><S><L><D><S><C><D><L><G><L><L><S><S><P><C><W><R><L><P><G><V><Y><W><Q><N><G><L><S><P><G><V><Q><S><T><L><E><P><S><T><A><K><P><T><E><F><S><W><P><G><T><Q><K><Q><Q><E><A><P><V><E><E><V><G><Q><A><E><E><P><D><R><L><R><L><Q><Q><L><P><W><S><S><P><L><H><P><W><D><R><Q><Q><D><T><E><V><C><D><S><G><C><L><L><E><R><R><H><P><P><A><L><Q><P><W><R><H><L><P><G><F><S><D><C><L><E><W><I><L><R><V><G><F><A><A><F><S><V><L><W><A><C><C><S><R><I><C><G><A><K><Q><P>
May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.<BOP>
Q3ZCQ2
Q9H444
CHM4B_HUMAN
Vacuolar protein sorting-associated protein 32-2
Homo
<M><S><V><F><G><K><L><F><G><A><G><G><G><K><A><G><K><G><G><P><T><P><Q><E><A><I><Q><R><L><R><D><T><E><E><M><L><S><K><K><Q><E><F><L><E><K><K><I><E><Q><E><L><T><A><A><K><K><H><G><T><K><N><K><R><A><A><L><Q><A><L><K><R><K><K><R><Y><E><K><Q><L><A><Q><I><D><G><T><L><S><T><I><E><F><Q><R><E><A><L><E><N><A><N><T><N><T><E><V><L><K><N><M><G><Y><A><A><K><A><M><K><A><A><H><D><N><M><D><I><D><K><V><D><E><L><M><Q><D><I><A><D><Q><Q><E><L><A><E><E><I><S><T><A><I><S><K><P><V><G><F><G><E><E><F><D><E><D><E><L><M><A><E><L><E><E><L><E><Q><E><E><L><D><K><N><L><L><E><I><S><G><P><E><T><V><P><L><P><N><V><P><S><I><A><L><P><S><K><P><A><K><K><K><E><E><E><D><D><D><M><K><E><L><E><N><W><A><G><S><M>
(Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.<BOP>
Q9H444
Q8NCK3
ZN485_HUMAN
Zinc finger protein 485
Homo
<M><A><P><R><A><Q><I><Q><G><P><L><T><F><G><D><V><A><V><A><F><T><R><I><E><W><R><H><L><D><A><A><Q><R><A><L><Y><R><D><V><M><L><E><N><Y><G><N><L><V><S><V><G><L><L><S><S><K><P><K><L><I><T><Q><L><E><Q><G><A><E><P><W><T><E><V><R><E><A><P><S><G><T><H><A><V><E><D><Y><W><F><E><T><K><M><S><A><L><K><Q><S><T><S><E><A><S><V><L><G><E><R><T><K><S><V><M><M><E><K><G><L><D><W><E><G><R><S><S><T><E><K><N><Y><K><C><K><E><C><G><K><V><F><K><Y><N><S><S><F><I><S><H><Q><R><N><H><T><S><E><K><P><H><K><C><K><E><C><G><I><A><F><M><N><S><S><S><L><L><N><H><H><K><V><H><A><G><K><Q><P><Y><R><C><I><E><C><G><K><F><L><K><K><H><S><T><F><I><N><H><Q><R><I><H><S><R><E><K><P><H><K><C><I><E><C><G><K><T><F><R><K><N><S><I><L><L><S><H><Q><R><I><H><T><G><Q><K><P><Y><K><C><N><D><C><G><K><A><F><A><Q><N><A><A><L><T><R><H><E><R><I><H><S><G><E><K><P><F><K><C><N><K><C><G><R><A><F><R><D><N><S><T><V><L><E><H><Q><K><I><H><T><G><E><K><P><Y><Q><C><N><E><C><G><K><A><F><R><K><S><S><T><L><I><S><H><Q><R><M><H><T><G><E><K><P><Y><H><C><S><K><C><G><K><S><F><R><Y><S><S><S><F><A><G><H><Q><K><T><H><S><G><N><K><P><Y><Q><C><R><D><C><G><K><A><F><T><K><S><S><T><L><T><G><H><Q><R><I><H><T><G><E><K><P><Y><H><C><K><K><C><G><K><A><F><R><H><S><S><G><L><V><E><H><Q><R><L><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><P><R><S><S><A><L><K><Q><H><K><K><I><H><N><K><E><R><A><M><K><C><S>
May be involved in transcriptional regulation.<BOP>
Q8NCK3
P03905
NU4M_HUMAN
NADH dehydrogenase subunit 4
Homo
<M><L><K><L><I><V><P><T><I><M><L><L><P><L><T><W><L><S><K><K><H><M><I><W><I><N><T><T><T><H><S><L><I><I><S><I><I><P><L><L><F><F><N><Q><I><N><N><N><L><F><S><C><S><P><T><F><S><S><D><P><L><T><T><P><L><L><M><L><T><T><W><L><L><P><L><T><I><M><A><S><Q><R><H><L><S><S><E><P><L><S><R><K><K><L><Y><L><S><M><L><I><S><L><Q><I><S><L><I><M><T><F><T><A><T><E><L><I><M><F><Y><I><F><F><E><T><T><L><I><P><T><L><A><I><I><T><R><W><G><N><Q><P><E><R><L><N><A><G><T><Y><F><L><F><Y><T><L><V><G><S><L><P><L><L><I><A><L><I><Y><T><H><N><T><L><G><S><L><N><I><L><L><L><T><L><T><A><Q><E><L><S><N><S><W><A><N><N><L><M><W><L><A><Y><T><M><A><F><M><V><K><M><P><L><Y><G><L><H><L><W><L><P><K><A><H><V><E><A><P><I><A><G><S><M><V><L><A><A><V><L><L><K><L><G><G><Y><G><M><M><R><L><T><L><I><L><N><P><L><T><K><H><M><A><Y><P><F><L><V><L><S><L><W><G><M><I><M><T><S><S><I><C><L><R><Q><T><D><L><K><S><L><I><A><Y><S><S><I><S><H><M><A><L><V><V><T><A><I><L><I><Q><T><P><W><S><F><T><G><A><V><I><L><M><I><A><H><G><L><T><S><S><L><L><F><C><L><A><N><S><N><Y><E><R><T><H><S><R><I><M><I><L><S><Q><G><L><Q><T><L><L><P><L><M><A><F><W><W><L><L><A><S><L><A><N><L><A><L><P><P><T><I><N><L><L><G><E><L><S><V><L><V><T><T><F><S><W><S><N><I><T><L><L><L><T><G><L><N><M><L><V><T><A><L><Y><S><L><Y><M><F><T><T><T><Q><W><G><S><L><T><H><H><I><N><N><M><K><P><S><F><T><R><E><N><T><L><M><F><M><H><L><S><P><I><L><L><L><S><L><N><P><D><I><I><T><G><F><S><S>
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity and assembly of complex I .<BOP>
P03905
P23588
IF4B_HUMAN
Eukaryotic translation initiation factor 4B
Homo
<M><A><A><S><A><K><K><K><N><K><K><G><K><T><I><S><L><T><D><F><L><A><E><D><G><G><T><G><G><G><S><T><Y><V><S><K><P><V><S><W><A><D><E><T><D><D><L><E><G><D><V><S><T><T><W><H><S><N><D><D><D><V><Y><R><A><P><P><I><D><R><S><I><L><P><T><A><P><R><A><A><R><E><P><N><I><D><R><S><R><L><P><K><S><P><P><Y><T><A><F><L><G><N><L><P><Y><D><V><T><E><E><S><I><K><E><F><F><R><G><L><N><I><S><A><V><R><L><P><R><E><P><S><N><P><E><R><L><K><G><F><G><Y><A><E><F><E><D><L><D><S><L><L><S><A><L><S><L><N><E><E><S><L><G><N><R><R><I><R><V><D><V><A><D><Q><A><Q><D><K><D><R><D><D><R><S><F><G><R><D><R><N><R><D><S><D><K><T><D><T><D><W><R><A><R><P><A><T><D><S><F><D><D><Y><P><P><R><R><G><D><D><S><F><G><D><K><Y><R><D><R><Y><D><S><D><R><Y><R><D><G><Y><R><D><G><Y><R><D><G><P><R><R><D><M><D><R><Y><G><G><R><D><R><Y><D><D><R><G><S><R><D><Y><D><R><G><Y><D><S><R><I><G><S><G><R><R><A><F><G><S><G><Y><R><R><D><D><D><Y><R><G><G><G><D><R><Y><E><D><R><Y><D><R><R><D><D><R><S><W><S><S><R><D><D><Y><S><R><D><D><Y><R><R><D><D><R><G><P><P><Q><R><P><K><L><N><L><K><P><R><S><T><P><K><E><D><D><S><S><A><S><T><S><Q><S><T><R><A><A><S><I><F><G><G><A><K><P><V><D><T><A><A><R><E><R><E><V><E><E><R><L><Q><K><E><Q><E><K><L><Q><R><Q><L><D><E><P><K><L><E><R><R><P><R><E><R><H><P><S><W><R><S><E><E><T><Q><E><R><E><R><S><R><T><G><S><E><S><S><Q><T><G><T><S><T><T><S><S><R><N><A><R><R><R><E><S><E><K><S><L><E><N><E><T><L><N><K><E><E><D><C><H><S><P><T><S><K><P><P><K><P><D><Q><P><L><K><V><M><P><A><P><P><P><K><E><N><A><W><V><K><R><S><S><N><P><P><A><R><S><Q><S><S><D><T><E><Q><Q><S><P><T><S><G><G><G><K><V><A><P><A><Q><P><S><E><E><G><P><G><R><K><D><E><N><K><V><D><G><M><N><A><P><K><G><Q><T><G><N><S><S><R><G><P><G><D><G><G><N><R><D><H><W><K><E><S><D><R><K><D><G><K><K><D><Q><D><S><R><S><A><P><E><P><K><K><P><E><E><N><P><A><S><K><F><S><S><A><S><K><Y><A><A><L><S><V><D><G><E><D><E><N><E><G><E><D><Y><A><E>
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.<BOP>
P23588
P56851
EP3B_HUMAN
Human epididymis-specific protein 3-beta
Homo
<M><A><S><S><L><K><I><W><G><T><L><L><A><L><L><C><I><L><C><T><L><L><V><Q><S><K><E><V><S><W><R><E><F><M><K><Q><H><Y><L><S><P><S><R><E><F><R><E><Y><K><C><D><V><L><M><R><E><N><E><A><L><K><D><K><S><S><H><M><F><I><Y><I><S><W><Y><K><I><E><H><I><C><T><S><D><N><W><M><D><R><F><R><N><A><Y><V><W><V><Q><N><P><L><K><V><L><K><C><H><Q><E><N><S><K><N><S><Y><T><E><S><R><S><F><N><Y><I><E><F><H><C><S><M><D><G><Y><V><D><S><I><E><D><L><K><M><V><E><P><I><G><N>
Possible function in sperm maturation.<BOP>
P56851
Q8IXY8
PPIL6_HUMAN
Rotamase PPIL6
Homo
<M><A><R><P><Q><P><C><G><P><P><H><A><R><C><G><S><P><S><L><P><E><R><P><L><Q><V><K><V><V><G><L><F><S><C><P><N><F><Q><I><A><K><S><A><A><E><N><L><K><N><N><H><P><S><K><F><E><D><P><I><L><V><P><L><Q><E><F><A><W><H><Q><Y><L><Q><E><K><K><R><E><L><K><N><E><T><W><E><Y><S><S><S><V><I><S><F><V><N><G><Q><F><L><G><D><A><L><D><L><Q><K><W><A><H><E><V><W><D><I><V><D><I><K><P><S><A><L><Y><D><A><L><T><E><D><F><S><A><K><F><L><R><D><T><K><H><D><F><V><F><L><D><I><C><I><D><S><S><P><I><G><R><L><I><F><E><L><Y><C><D><V><C><P><K><T><C><K><N><F><Q><V><L><C><T><G><K><A><G><F><S><Q><R><G><I><R><L><H><Y><K><N><S><I><F><H><R><I><V><Q><N><G><W><I><Q><G><G><D><I><V><Y><G><K><G><D><N><G><E><S><I><Y><G><P><T><F><E><D><E><N><F><S><V><P><H><N><K><R><G><V><L><G><M><A><N><K><G><R><H><S><N><G><S><Q><F><Y><I><T><L><Q><A><T><P><Y><L><D><R><K><F><V><A><F><G><Q><L><I><E><G><T><E><V><L><K><Q><L><E><L><V><P><T><Q><N><E><R><P><I><H><M><C><R><I><T><D><S><G><D><P><Y><A>
Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.<BOP>
Q8IXY8