accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q9NVH6 | TMLH_HUMAN | TML-alpha-ketoglutarate dioxygenase | Homo | <M><W><Y><H><R><L><S><H><L><H><S><R><L><Q><D><L><L><K><G><G><V><I><Y><P><A><L><P><Q><P><N><F><K><S><L><L><P><L><A><V><H><W><H><H><T><A><S><K><S><L><T><C><A><W><Q><Q><H><E><D><H><F><E><L><K><Y><A><N><T><V><M><R><F><D><Y><V><W><L><R><D><H><C><R><S><A><S><C><Y><N><S><K><T><H><Q><R><S><L><D><T><A><S><V><D><L><C><I><K><P><K><T><I><R><L><D><E><T><T><L><F><F><T><W><P><D><G><H><V><T><K><Y><D><L><N><W><L><V><K><N><S><Y><E><G><Q><K><Q><K><V><I><Q><P><R><I><L><W><N><A><E><I><Y><Q><Q><A><Q><V><P><S><V><D><C><Q><S><F><L><E><T><N><E><G><L><K><K><F><L><Q><N><F><L><L><Y><G><I><A><F><V><E><N><V><P><P><T><Q><E><H><T><E><K><L><A><E><R><I><S><L><I><R><E><T><I><Y><G><R><M><W><Y><F><T><S><D><F><S><R><G><D><T><A><Y><T><K><L><A><L><D><R><H><T><D><T><T><Y><F><Q><E><P><C><G><I><Q><V><F><H><C><L><K><H><E><G><T><G><G><R><T><L><L><V><D><G><F><Y><A><A><E><Q><V><L><Q><K><A><P><E><E><F><E><L><L><S><K><V><P><L><K><H><E><Y><I><E><D><V><G><E><C><H><N><H><M><I><G><I><G><P><V><L><N><I><Y><P><W><N><K><E><L><Y><L><I><R><Y><N><N><Y><D><R><A><V><I><N><T><V><P><Y><D><V><V><H><R><W><Y><T><A><H><R><T><L><T><I><E><L><R><R><P><E><N><E><F><W><V><K><L><K><P><G><R><V><L><F><I><D><N><W><R><V><L><H><G><R><E><C><F><T><G><Y><R><Q><L><C><G><C><Y><L><T><R><D><D><V><L><N><T><A><R><L><L><G><L><Q><A> | Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) .<BOP> | Q9NVH6 |
Q92597 | NDRG1_HUMAN | Rit42 | Homo | <M><S><R><E><M><Q><D><V><D><L><A><E><V><K><P><L><V><E><K><G><E><T><I><T><G><L><L><Q><E><F><D><V><Q><E><Q><D><I><E><T><L><H><G><S><V><H><V><T><L><C><G><T><P><K><G><N><R><P><V><I><L><T><Y><H><D><I><G><M><N><H><K><T><C><Y><N><P><L><F><N><Y><E><D><M><Q><E><I><T><Q><H><F><A><V><C><H><V><D><A><P><G><Q><Q><D><G><A><A><S><F><P><A><G><Y><M><Y><P><S><M><D><Q><L><A><E><M><L><P><G><V><L><Q><Q><F><G><L><K><S><I><I><G><M><G><T><G><A><G><A><Y><I><L><T><R><F><A><L><N><N><P><E><M><V><E><G><L><V><L><I><N><V><N><P><C><A><E><G><W><M><D><W><A><A><S><K><I><S><G><W><T><Q><A><L><P><D><M><V><V><S><H><L><F><G><K><E><E><M><Q><S><N><V><E><V><V><H><T><Y><R><Q><H><I><V><N><D><M><N><P><G><N><L><H><L><F><I><N><A><Y><N><S><R><R><D><L><E><I><E><R><P><M><P><G><T><H><T><V><T><L><Q><C><P><A><L><L><V><V><G><D><S><S><P><A><V><D><A><V><V><E><C><N><S><K><L><D><P><T><K><T><T><L><L><K><M><A><D><C><G><G><L><P><Q><I><S><Q><P><A><K><L><A><E><A><F><K><Y><F><V><Q><G><M><G><Y><M><P><S><A><S><M><T><R><L><M><R><S><R><T><A><S><G><S><S><V><T><S><L><D><G><T><R><S><R><S><H><T><S><E><G><T><R><S><R><S><H><T><S><E><G><T><R><S><R><S><H><T><S><E><G><A><H><L><D><I><T><P><N><S><G><A><A><G><N><S><A><G><P><K><S><M><E><V><S><C> | Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.<BOP> | Q92597 |
Q9NX65 | ZSC32_HUMAN | Zinc finger protein 434 | Homo | <M><M><A><A><V><K><S><T><E><A><H><P><S><S><N><K><D><P><T><Q><G><Q><K><S><A><L><Q><G><N><S><P><D><S><E><A><S><R><Q><R><F><R><Q><F><C><Y><Q><E><V><T><G><P><H><E><A><F><S><K><L><W><E><L><C><C><Q><W><L><R><P><K><T><H><S><K><E><E><I><L><E><L><L><V><L><E><Q><F><L><T><I><L><P><E><E><I><Q><T><W><V><R><E><Q><H><P><E><N><G><E><E><A><V><A><L><V><E><D><V><Q><R><A><P><G><Q><Q><V><L><D><S><E><K><D><L><K><V><L><M><K><E><M><A><P><L><G><A><T><R><E><S><L><R><S><Q><W><K><Q><E><V><Q><P><E><E><P><T><F><K><G><S><Q><S><S><H><Q><R><P><G><E><Q><S><E><A><W><L><A><P><Q><A><P><R><N><L><P><Q><N><T><G><L><H><D><Q><E><T><G><A><V><V><W><T><A><G><S><Q><G><P><A><M><R><D><N><R><A><V><S><L><C><Q><Q><E><W><M><C><P><G><P><A><Q><R><A><L><Y><R><G><A><T><Q><R><K><D><S><H><V><S><L><A><T><G><V><P><W><G><Y><E><E><T><K><T><L><L><A><I><L><S><S><S><Q><F><Y><G><K><L><Q><T><C><Q><Q><N><S><Q><I><Y><R><A><M><A><E><G><L><W><E><Q><G><F><L><R><T><P><E><Q><C><R><T><K><F><K><S><L><Q><L><S><Y><R><K><V><R><R><G><R><V><P><E><P><C><I><F><Y><E><E><M><N><A><L><S><G><S><W><A><S><A><P><P><M><A><S><D><A><V><P><G><Q><E><G><S><D><I><E><A><G><E><L><N><H><Q><N><G><E><P><T><E><V><E><D><G><T><V><D><G><A><D><R><D><E><K><D><F><R><N><P><G><Q><E><V><R><K><L><D><L><P><V><L><F><P><N><R><L><G><F><E><F><K><N><E><I><K><K><E><N><L><K><W><D><D><S><E><E><V><E><I><N><K><A><L><Q><R><K><S><R><G><V><Y><W><H><S><E><L><Q><K><G><L><E><S><E><P><T><S><R><R><Q><C><R><N><S><P><G><E><S><E><E><K><T><P><S><Q><E><K><M><S><H><Q><S><F><C><A><R><D><K><A><C><T><H><I><L><C><G><K><N><C><S><Q><S><V><H><S><P><H><K><P><A><L><K><L><E><K><V><S><Q><C><P><E><C><G><K><T><F><S><R><S><S><Y><L><V><R><H><Q><R><I><H><T><G><E><K><P><H><K><C><S><E><C><G><K><G><F><S><E><R><S><N><L><T><A><H><L><R><T><H><T><G><E><R><P><Y><Q><C><G><Q><C><G><K><S><F><N><Q><S><S><S><L><I><V><H><Q><R><T><H><T><G><E><K><P><Y><Q><C><I><V><C><G><K><R><F><N><N><S><S><Q><F><S><A><H><R><R><I><H><T><G><E><S><P><Y><K><C><A><V><C><G><K><I><F><N><N><S><S><H><F><S><A><H><R><K><T><H><T><G><E><K><P><Y><R><C><S><H><C><E><R><G><F><T><K><N><S><A><L><T><R><H><Q><T><V><H><M><K><A><V><L><S><S><Q><E><G><R><D><A><L> | May be involved in transcriptional regulation.<BOP> | Q9NX65 |
A0A0B4J280 | TVA40_HUMAN | T cell receptor alpha variable 40 | Homo | <M><N><S><S><L><D><F><L><I><L><I><L><M><F><G><G><T><S><S><N><S><V><K><Q><T><G><Q><I><T><V><S><E><G><A><S><V><T><M><N><C><T><Y><T><S><T><G><Y><P><T><L><F><W><Y><V><E><Y><P><S><K><P><L><Q><L><L><Q><R><E><T><M><E><N><S><K><N><F><G><G><G><N><I><K><D><K><N><S><P><I><V><K><Y><S><V><Q><V><S><D><S><A><V><Y><Y><C><L><L><G> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0B4J280 |
A0A0C4DH73 | KV112_HUMAN | Immunoglobulin kappa variable 1-12 | Homo | <M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><F><P><G><S><R><C><D><I><Q><M><T><Q><S><P><S><S><V><S><A><S><V><G><D><R><V><T><I><T><C><R><A><S><Q><G><I><S><S><W><L><A><W><Y><Q><Q><K><P><G><K><A><P><K><L><L><I><Y><A><A><S><S><L><Q><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><P><E><D><F><A><T><Y><Y><C><Q><Q><A><N><S><F><P> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A0C4DH73 |
P35663 | CYLC1_HUMAN | Multiple-band polypeptide I | Homo | <M><S><L><P><R><L><L><K><V><N><I><R><T><Y><D><N><S><I><P><I><S><E><S><S><R><K><S><W><N><Q><K><H><F><A><L><T><F><P><K><P><L><Q><R><G><T><N><D><K><S><R><P><L><K><S><Q><I><T><V><T><R><H><D><K><R><K><L><E><E><G><Q><K><P><A><H><K><W><I><R><H><S><F><R><K><I><L><Q><W><P><P><I><Y><T><A><A><R><E><Q><T><P><F><R><H><L><Y><T><S><K><T><H><L><K><K><A><E><Y><K><K><S><K><D><E><K><G><G><T><P><L><K><K><D><S><K><K><K><G><G><S><Y><A><T><N><P><E><S><K><Q><I><V><E><E><K><T><K><R><Q><N><E><A><D><K><T><P><L><K><S><S><H><E><N><E><Q><S><K><K><S><K><S><S><S><E><T><N><P><E><S><Q><N><S><K><T><V><S><K><N><C><S><Q><K><D><K><K><D><S><K><N><S><K><K><T><N><T><E><F><L><H><T><K><N><N><P><K><K><D><L><K><R><S><K><T><S><N><D><P><I><S><E><I><C><S><E><N><S><L><N><V><D><F><L><M><L><V><G><Q><S><D><D><E><S><I><N><F><D><A><W><L><R><N><Y><S><Q><N><N><S><K><N><Y><S><L><K><Y><T><K><Y><T><K><K><D><T><K><K><N><A><K><K><S><S><D><A><E><S><E><D><S><K><D><A><K><K><D><S><K><K><V><K><K><N><V><K><K><D><D><K><K><K><D><V><K><K><D><T><E><S><T><D><A><E><S><G><D><S><K><D><E><R><K><D><T><K><K><D><K><K><K><L><K><K><D><D><K><K><K><D><T><K><K><Y><P><E><S><T><D><T><E><S><G><D><A><K><D><A><R><N><D><S><R><N><L><K><K><A><S><K><N><D><D><K><K><K><D><A><K><K><I><T><F><S><T><D><S><E><S><E><L><E><S><K><E><S><Q><K><D><E><K><K><D><K><K><D><S><K><T><D><N><K><K><S><V><K><N><D><E><E><S><T><D><A><D><S><E><P><K><G><D><S><K><K><G><K><K><D><E><K><K><G><K><K><D><S><K><K><D><D><K><K><K><D><A><K><K><N><A><E><S><T><E><M><E><S><D><L><E><L><K><K><D><K><K><H><S><K><E><K><K><G><S><K><K><D><I><K><K><D><A><R><K><D><T><E><S><T><D><A><E><F><D><E><S><S><K><T><G><F><K><T><S><T><K><I><K><G><S><D><T><E><S><E><E><S><L><Y><K><P><G><A><K><K><K><I><D><E><S><D><G><T><S><A><N><S><K><M><E><G><L><E><S><K><R><G><F><R><M><S><S><K><K><T><T><F><N><E><K><G><E><K><A><S><T><G><R><V><P><P><S><R><E><K><P><P><L><P><A><C><E><P><S><L><P><S><P><K><V><R><R><L><C><W><C><K><M><P><P><P><P><P><K><P><R><Y><A><P><L><P><E><A><P><W><I><H><K><L><L> | Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.<BOP> | P35663 |
Q9NUM3 | S39A9_HUMAN | Zrt- and Irt-like protein 9 | Homo | <M><D><D><F><I><S><I><S><L><L><S><L><A><M><L><V><G><C><Y><V><A><G><I><I><P><L><A><V><N><F><S><E><E><R><L><K><L><V><T><V><L><G><A><G><L><L><C><G><T><A><L><A><V><I><V><P><E><G><V><H><A><L><Y><E><D><I><L><E><G><K><H><H><Q><A><S><E><T><H><N><V><I><A><S><D><K><A><A><E><K><S><V><V><H><E><H><E><H><S><H><D><H><T><Q><L><H><A><Y><I><G><V><S><L><V><L><G><F><V><F><M><L><L><V><D><Q><I><G><N><S><H><V><H><S><T><D><D><P><E><A><A><R><S><S><N><S><K><I><T><T><T><L><G><L><V><V><H><A><A><A><D><G><V><A><L><G><A><A><A><S><T><S><Q><T><S><V><Q><L><I><V><F><V><A><I><M><L><H><K><A><P><A><A><F><G><L><V><S><F><L><M><H><A><G><L><E><R><N><R><I><R><K><H><L><L><V><F><A><L><A><A><P><V><M><S><M><V><T><Y><L><G><L><S><K><S><S><K><E><A><L><S><E><V><N><A><T><G><V><A><M><L><F><S><A><G><T><F><L><Y><V><A><T><V><H><V><L><P><E><V><G><G><I><G><H><S><H><K><P><D><A><T><G><G><R><G><L><S><R><L><E><V><A><A><L><V><L><G><C><L><I><P><L><I><L><S><V><G><H><Q><H> | May act as a zinc-influx transporter.<BOP> | Q9NUM3 |
P78383 | S35B1_HUMAN | UDP-galactose transporter-related protein 1 | Homo | <M><A><S><S><S><S><L><V><P><D><R><L><R><L><P><L><C><F><L><G><V><F><V><C><Y><F><Y><Y><G><I><L><Q><E><K><I><T><R><G><K><Y><G><E><G><A><K><Q><E><T><F><T><F><A><L><T><L><V><F><I><Q><C><V><I><N><A><V><F><A><K><I><L><I><Q><F><F><D><T><A><R><V><D><R><T><R><S><W><L><Y><A><A><C><S><I><S><Y><L><G><A><M><V><S><S><N><S><A><L><Q><F><V><N><Y><P><T><Q><V><L><G><K><S><C><K><P><I><P><V><M><L><L><G><V><T><L><L><K><K><K><Y><P><L><A><K><Y><L><C><V><L><L><I><V><A><G><V><A><L><F><M><Y><K><P><K><K><V><V><G><I><E><E><H><T><V><G><Y><G><E><L><L><L><L><L><S><L><T><L><D><G><L><T><G><V><S><Q><D><H><M><R><A><H><Y><Q><T><G><S><N><H><M><M><L><N><I><N><L><W><S><T><L><L><L><G><M><G><I><L><F><T><G><E><L><W><E><F><L><S><F><A><E><R><Y><P><A><I><I><Y><N><I><L><L><F><G><L><T><S><A><L><G><Q><S><F><I><F><M><T><V><V><Y><F><G><P><L><T><C><S><I><I><T><T><T><R><K><F><F><T><I><L><A><S><V><I><L><F><A><N><P><I><S><P><M><Q><W><V><G><T><V><L><V><F><L><G><L><G><L><D><A><K><F><G><K><G><A><K><K><T><S><H> | ATP:ADP antiporter.<BOP> | P78383 |
Q13636 | RAB31_HUMAN | Ras-related protein Rab-22B | Homo | <M><A><I><R><E><L><K><V><C><L><L><G><D><T><G><V><G><K><S><S><I><V><C><R><F><V><Q><D><H><F><D><H><N><I><S><P><T><I><G><A><S><F><M><T><K><T><V><P><C><G><N><E><L><H><K><F><L><I><W><D><T><A><G><Q><E><R><F><H><S><L><A><P><M><Y><Y><R><G><S><A><A><A><V><I><V><Y><D><I><T><K><Q><D><S><F><Y><T><L><K><K><W><V><K><E><L><K><E><H><G><P><E><N><I><V><M><A><I><A><G><N><K><C><D><L><S><D><I><R><E><V><P><L><K><D><A><K><E><Y><A><E><S><I><G><A><I><V><V><E><T><S><A><K><N><A><I><N><I><E><E><L><F><Q><G><I><S><R><Q><I><P><P><L><D><P><H><E><N><G><N><N><G><T><I><K><V><E><K><P><T><M><Q><A><S><R><R><C><C> | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<BOP> | Q13636 |
P78329 | CP4F2_HUMAN | Phylloquinone omega-hydroxylase CYP4F2 | Homo | <M><S><Q><L><S><L><S><W><L><G><L><W><P><V><A><A><S><P><W><L><L><L><L><L><V><G><A><S><W><L><L><A><H><V><L><A><W><T><Y><A><F><Y><D><N><C><R><R><L><R><C><F><P><Q><P><P><R><R><N><W><F><W><G><H><Q><G><M><V><N><P><T><E><E><G><M><R><V><L><T><Q><L><V><A><T><Y><P><Q><G><F><K><V><W><M><G><P><I><S><P><L><L><S><L><C><H><P><D><I><I><R><S><V><I><N><A><S><A><A><I><A><P><K><D><K><F><F><Y><S><F><L><E><P><W><L><G><D><G><L><L><L><S><A><G><D><K><W><S><R><H><R><R><M><L><T><P><A><F><H><F><N><I><L><K><P><Y><M><K><I><F><N><E><S><V><N><I><M><H><A><K><W><Q><L><L><A><S><E><G><S><A><C><L><D><M><F><E><H><I><S><L><M><T><L><D><S><L><Q><K><C><V><F><S><F><D><S><H><C><Q><E><K><P><S><E><Y><I><A><A><I><L><E><L><S><A><L><V><S><K><R><H><H><E><I><L><L><H><I><D><F><L><Y><Y><L><T><P><D><G><Q><R><F><R><R><A><C><R><L><V><H><D><F><T><D><A><V><I><Q><E><R><R><R><T><L><P><S><Q><G><V><D><D><F><L><Q><A><K><A><K><S><K><T><L><D><F><I><D><V><L><L><L><S><K><D><E><D><G><K><K><L><S><D><E><D><I><R><A><E><A><D><T><F><M><F><E><G><H><D><T><T><A><S><G><L><S><W><V><L><Y><H><L><A><K><H><P><E><Y><Q><E><R><C><R><Q><E><V><Q><E><L><L><K><D><R><E><P><K><E><I><E><W><D><D><L><A><H><L><P><F><L><T><M><C><M><K><E><S><L><R><L><H><P><P><V><P><V><I><S><R><H><V><T><Q><D><I><V><L><P><D><G><R><V><I><P><K><G><I><I><C><L><I><S><V><F><G><T><H><H><N><P><A><V><W><P><D><P><E><V><Y><D><P><F><R><F><D><P><E><N><I><K><E><R><S><P><L><A><F><I><P><F><S><A><G><P><R><N><C><I><G><Q><T><F><A><M><A><E><M><K><V><V><L><A><L><T><L><L><R><F><R><V><L><P><D><H><T><E><P><R><R><K><P><E><L><V><L><R><A><E><G><G><L><W><L><R><V><E><P><L><S> | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) . Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure . Plays a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs . Catalyzes omega-hydroxylation of | P78329 |
P20719 | HXA5_HUMAN | Homeobox protein Hox-1C | Homo | <M><S><S><Y><F><V><N><S><F><C><G><R><Y><P><N><G><P><D><Y><Q><L><H><N><Y><G><D><H><S><S><V><S><E><Q><F><R><D><S><A><S><M><H><S><G><R><Y><G><Y><G><Y><N><G><M><D><L><S><V><G><R><S><G><S><G><H><F><G><S><G><E><R><A><R><S><Y><A><A><S><A><S><A><A><P><A><E><P><R><Y><S><Q><P><A><T><S><T><H><S><P><Q><P><D><P><L><P><C><S><A><V><A><P><S><P><G><S><D><S><H><H><G><G><K><N><S><L><S><N><S><S><G><A><S><A><D><A><G><S><T><H><I><S><S><R><E><G><V><G><T><A><S><G><A><E><E><D><A><P><A><S><S><E><Q><A><S><A><Q><S><E><P><S><P><A><P><P><A><Q><P><Q><I><Y><P><W><M><R><K><L><H><I><S><H><D><N><I><G><G><P><E><G><K><R><A><R><T><A><Y><T><R><Y><Q><T><L><E><L><E><K><E><F><H><F><N><R><Y><L><T><R><R><R><R><I><E><I><A><H><A><L><C><L><S><E><R><Q><I><K><I><W><F><Q><N><R><R><M><K><W><K><K><D><N><K><L><K><S><M><S><M><A><A><A><G><G><A><F><R><P> | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.<BOP> | P20719 |
Q8NGN0 | OR4D5_HUMAN | Olfactory receptor OR11-276 | Homo | <M><N><P><A><N><H><S><Q><V><A><G><F><V><L><L><G><L><S><Q><V><W><E><L><R><F><V><F><F><T><V><F><S><A><V><Y><F><M><T><V><V><G><N><L><L><I><V><V><I><V><T><S><D><P><H><L><H><T><T><M><Y><F><L><L><G><N><L><S><F><L><D><F><C><Y><S><S><I><T><A><P><R><M><L><V><D><L><L><S><G><N><P><T><I><S><F><G><G><C><L><T><Q><L><F><F><F><H><F><I><G><G><I><K><I><F><L><L><T><V><M><A><Y><D><R><Y><I><A><I><S><Q><P><L><H><Y><T><L><I><M><N><Q><T><V><C><A><L><L><M><A><A><S><W><V><G><G><F><I><H><S><I><V><Q><I><A><L><T><I><Q><L><P><F><C><G><P><D><K><L><D><N><F><Y><C><D><V><P><Q><L><I><K><L><A><C><T><D><T><F><V><L><E><L><L><M><V><S><N><N><G><L><V><T><L><M><C><F><L><V><L><L><G><S><Y><T><A><L><L><V><M><L><R><S><H><S><R><E><G><R><S><K><A><L><S><T><C><A><S><H><I><A><V><V><T><L><I><F><V><P><C><I><Y><V><Y><T><R><P><F><R><T><F><P><M><D><K><A><V><S><V><L><Y><T><I><V><T><P><M><L><N><P><A><I><Y><T><L><R><N><K><E><V><I><M><A><M><K><K><L><W><R><R><K><K><D><P><I><G><P><L><E><H><R><P><L><H> | Odorant receptor.<BOP> | Q8NGN0 |
O14843 | FFAR3_HUMAN | G-protein coupled receptor 41 | Homo | <M><D><T><G><P><D><Q><S><Y><F><S><G><N><H><W><F><V><F><S><V><Y><L><L><T><F><L><V><G><L><P><L><N><L><L><A><L><V><V><F><V><G><K><L><Q><R><R><P><V><A><V><D><V><L><L><L><N><L><T><A><S><D><L><L><L><L><L><F><L><P><F><R><M><V><E><A><A><N><G><M><H><W><P><L><P><F><I><L><C><P><L><S><G><F><I><F><F><T><T><I><Y><L><T><A><L><F><L><A><A><V><S><I><E><R><F><L><S><V><A><H><P><L><W><Y><K><T><R><P><R><L><G><Q><A><G><L><V><S><V><A><C><W><L><L><A><S><A><H><C><S><V><V><Y><V><I><E><F><S><G><D><I><S><H><S><Q><G><T><N><G><T><C><Y><L><E><F><R><K><D><Q><L><A><I><L><L><P><V><R><L><E><M><A><V><V><L><F><V><V><P><L><I><I><T><S><Y><C><Y><S><R><L><V><W><I><L><G><R><G><G><S><H><R><R><Q><R><R><V><A><G><L><L><A><A><T><L><L><N><F><L><V><C><F><G><P><Y><N><V><S><H><V><V><G><Y><I><C><G><E><S><P><A><W><R><I><Y><V><T><L><L><S><T><L><N><S><C><V><D><P><F><V><Y><Y><F><S><S><S><G><F><Q><A><D><F><H><E><L><L><R><R><L><C><G><L><W><G><Q><W><Q><Q><E><S><S><M><E><L><K><E><Q><K><G><G><E><E><Q><R><A><D><R><P><A><E><R><K><T><S><E><H><S><Q><G><C><G><T><G><G><Q><V><A><C><A><E><S> | G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation . Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. | O14843 |
Q6P2C8 | MED27_HUMAN | Transcriptional coactivator CRSP34 | Homo | <M><A><D><V><I><N><V><S><V><N><L><E><A><F><S><Q><A><I><S><A><I><Q><A><L><R><S><S><V><S><R><V><F><D><C><L><K><D><G><M><R><N><K><E><T><L><E><G><R><E><K><A><F><I><A><H><F><Q><D><N><L><H><S><V><N><R><D><L><N><E><L><E><R><L><S><N><L><V><G><K><P><S><E><N><H><P><L><H><N><S><G><L><L><S><L><D><P><V><Q><D><K><T><P><L><Y><S><Q><L><L><Q><A><Y><K><W><S><N><K><L><Q><Y><H><A><G><L><A><S><G><L><L><N><Q><Q><S><L><K><R><S><A><N><Q><M><G><V><S><A><K><R><R><P><K><A><Q><P><T><T><L><V><L><P><P><Q><Y><V><D><D><V><I><S><R><I><D><R><M><F><P><E><M><S><I><H><L><S><R><P><N><G><T><S><A><M><L><L><V><T><L><G><K><V><L><K><V><I><V><V><M><R><S><L><F><I><D><R><T><I><V><K><G><Y><N><E><N><V><Y><T><E><D><G><K><L><D><I><W><S><K><S><N><Y><Q><V><F><Q><K><V><T><D><H><A><T><T><A><L><L><H><Y><Q><L><P><Q><M><P><D><V><V><V><R><S><F><M><T><W><L><R><S><Y><I><K><L><F><Q><A><P><C><Q><R><C><G><K><F><L><Q><D><G><L><P><P><T><W><R><D><F><R><T><L><E><A><F><H><D><T><C><R><Q> | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<BOP> | Q6P2C8 |
A0A0C4DH62 | HJ01_HUMAN | Immunoglobulin heavy joining 1 | Homo | <A><E><Y><F><Q><H><W><G><Q><G><T><L><V><T><V><S><S> | J region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A0C4DH62 |
Q9UBD3 | XCL2_HUMAN | XC chemokine ligand 2 | Homo | <M><R><L><L><I><L><A><L><L><G><I><C><S><L><T><A><Y><I><V><E><G><V><G><S><E><V><S><H><R><R><T><C><V><S><L><T><T><Q><R><L><P><V><S><R><I><K><T><Y><T><I><T><E><G><S><L><R><A><V><I><F><I><T><K><R><G><L><K><V><C><A><D><P><Q><A><T><W><V><R><D><V><V><R><S><M><D><R><K><S><N><T><R><N><N><M><I><Q><T><K><P><T><G><T><Q><Q><S><T><N><T><A><V><T><L><T><G> | Chemotactic activity for lymphocytes but not for monocytes or neutrophils.<BOP> | Q9UBD3 |
P48643 | TCPE_HUMAN | CCT-epsilon | Homo | <M><A><S><M><G><T><L><A><F><D><E><Y><G><R><P><F><L><I><I><K><D><Q><D><R><K><S><R><L><M><G><L><E><A><L><K><S><H><I><M><A><A><K><A><V><A><N><T><M><R><T><S><L><G><P><N><G><L><D><K><M><M><V><D><K><D><G><D><V><T><V><T><N><D><G><A><T><I><L><S><M><M><D><V><D><H><Q><I><A><K><L><M><V><E><L><S><K><S><Q><D><D><E><I><G><D><G><T><T><G><V><V><V><L><A><G><A><L><L><E><E><A><E><Q><L><L><D><R><G><I><H><P><I><R><I><A><D><G><Y><E><Q><A><A><R><V><A><I><E><H><L><D><K><I><S><D><S><V><L><V><D><I><K><D><T><E><P><L><I><Q><T><A><K><T><T><L><G><S><K><V><V><N><S><C><H><R><Q><M><A><E><I><A><V><N><A><V><L><T><V><A><D><M><E><R><R><D><V><D><F><E><L><I><K><V><E><G><K><V><G><G><R><L><E><D><T><K><L><I><K><G><V><I><V><D><K><D><F><S><H><P><Q><M><P><K><K><V><E><D><A><K><I><A><I><L><T><C><P><F><E><P><P><K><P><K><T><K><H><K><L><D><V><T><S><V><E><D><Y><K><A><L><Q><K><Y><E><K><E><K><F><E><E><M><I><Q><Q><I><K><E><T><G><A><N><L><A><I><C><Q><W><G><F><D><D><E><A><N><H><L><L><L><Q><N><N><L><P><A><V><R><W><V><G><G><P><E><I><E><L><I><A><I><A><T><G><G><R><I><V><P><R><F><S><E><L><T><A><E><K><L><G><F><A><G><L><V><Q><E><I><S><F><G><T><T><K><D><K><M><L><V><I><E><Q><C><K><N><S><R><A><V><T><I><F><I><R><G><G><N><K><M><I><I><E><E><A><K><R><S><L><H><D><A><L><C><V><I><R><N><L><I><R><D><N><R><V><V><Y><G><G><G><A><A><E><I><S><C><A><L><A><V><S><Q><E><A><D><K><C><P><T><L><E><Q><Y><A><M><R><A><F><A><D><A><L><E><V><I><P><M><A><L><S><E><N><S><G><M><N><P><I><Q><T><M><T><E><V><R><A><R><Q><V><K><E><M><N><P><A><L><G><I><D><C><L><H><K><G><T><N><D><M><K><Q><Q><H><V><I><E><T><L><I><G><K><K><Q><Q><I><S><L><A><T><Q><M><V><R><M><I><L><K><I><D><D><I><R><K><P><G><E><S><E><E> | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis . The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance . As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . The TRiC complex plays a role in the folding of actin and tubulin (Probable).<BOP> | P48643 |
P46952 | 3HAO_HUMAN | 3-hydroxyanthranilic acid dioxygenase | Homo | <M><E><R><R><L><G><V><R><A><W><V><K><E><N><R><G><S><F><Q><P><P><V><C><N><K><L><M><H><Q><E><Q><L><K><V><M><F><I><G><G><P><N><T><R><K><D><Y><H><I><E><E><G><E><E><V><F><Y><Q><L><E><G><D><M><V><L><R><V><L><E><Q><G><K><H><R><D><V><V><I><R><Q><G><E><I><F><L><L><P><A><R><V><P><H><S><P><Q><R><F><A><N><T><V><G><L><V><V><E><R><R><R><L><E><T><E><L><D><G><L><R><Y><Y><V><G><D><T><M><D><V><L><F><E><K><W><F><Y><C><K><D><L><G><T><Q><L><A><P><I><I><Q><E><F><F><S><S><E><Q><Y><R><T><G><K><P><I><P><D><Q><L><L><K><E><P><P><F><P><L><S><T><R><S><I><M><E><P><M><S><L><D><A><W><L><D><S><H><H><R><E><L><Q><A><G><T><P><L><S><L><F><G><D><T><Y><E><T><Q><V><I><A><Y><G><Q><G><S><S><E><G><L><R><Q><N><V><D><V><W><L><W><Q><L><E><G><S><S><V><V><T><M><G><G><R><R><L><S><L><A><P><D><D><S><L><L><V><L><A><G><T><S><Y><A><W><E><R><T><Q><G><S><V><A><L><S><V><T><Q><D><P><A><C><K><K><P><L><G> | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.<BOP> | P46952 |
Q14129 | DGCR6_HUMAN | DiGeorge syndrome critical region 6 | Homo | <M><E><R><Y><A><G><A><L><E><E><V><A><D><G><A><R><Q><Q><E><R><H><Y><Q><L><L><S><A><L><Q><S><L><V><K><E><L><P><S><S><F><Q><Q><R><L><S><Y><T><T><L><S><D><L><A><L><A><L><L><D><G><T><V><F><E><I><V><Q><G><L><L><E><I><Q><H><L><T><E><K><S><L><Y><N><Q><R><L><R><L><Q><N><E><H><R><V><L><R><Q><A><L><R><Q><K><H><Q><E><A><Q><Q><A><C><R><P><H><N><L><P><V><L><Q><A><A><Q><Q><R><E><L><E><A><V><E><H><R><I><R><E><E><Q><R><A><M><D><Q><K><I><V><L><E><L><D><R><K><V><A><D><Q><Q><S><T><L><E><K><A><G><V><A><G><F><Y><V><T><T><N><P><Q><E><L><M><L><Q><M><N><L><L><E><L><I><R><K><L><Q><Q><R><G><C><W><A><G><K><A><A><L><G><L><G><G><P><W><Q><L><P><A><A><Q><C><D><Q><K><G><S><P><V><P><P> | May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.<BOP> | Q14129 |
Q9H2G4 | TSYL2_HUMAN | Nuclear protein of 79 kDa | Homo | <M><D><R><P><D><E><G><P><P><A><K><T><R><R><L><S><S><S><E><S><P><Q><R><D><P><P><P><P><P><P><P><P><P><L><L><R><L><P><L><P><P><P><Q><Q><R><P><R><L><Q><E><E><T><E><A><A><Q><V><L><A><D><M><R><G><V><G><L><G><P><A><L><P><P><P><P><P><Y><V><I><L><E><E><G><G><I><R><A><Y><F><T><L><G><A><E><C><P><G><W><D><S><T><I><E><S><G><Y><G><E><A><P><P><P><T><E><S><L><E><A><L><P><T><P><E><A><S><G><G><S><L><E><I><D><F><Q><V><V><Q><S><S><S><F><G><G><E><G><A><L><E><T><C><S><A><V><G><W><A><P><Q><R><L><V><D><P><K><S><K><E><E><A><I><I><I><V><E><D><E><D><E><D><E><R><E><S><M><R><S><S><R><R><R><R><R><R><R><R><R><K><Q><R><K><V><K><R><E><S><R><E><R><N><A><E><R><M><E><S><I><L><Q><A><L><E><D><I><Q><L><D><L><E><A><V><N><I><K><A><G><K><A><F><L><R><L><K><R><K><F><I><Q><M><R><R><P><F><L><E><R><R><D><L><I><I><Q><H><I><P><G><F><W><V><K><A><F><L><N><H><P><R><I><S><I><L><I><N><R><R><D><E><D><I><F><R><Y><L><T><N><L><Q><V><Q><D><L><R><H><I><S><M><G><Y><K><M><K><L><Y><F><Q><T><N><P><Y><F><T><N><M><V><I><V><K><E><F><Q><R><N><R><S><G><R><L><V><S><H><S><T><P><I><R><W><H><R><G><Q><E><P><Q><A><R><R><H><G><N><Q><D><A><S><H><S><F><F><S><W><F><S><N><H><S><L><P><E><A><D><R><I><A><E><I><I><K><N><D><L><W><V><N><P><L><R><Y><Y><L><R><E><R><G><S><R><I><K><R><K><K><Q><E><M><K><K><R><K><T><R><G><R><C><E><V><V><I><M><E><D><A><P><D><Y><Y><A><V><E><D><I><F><S><E><I><S><D><I><D><E><T><I><H><D><I><K><I><S><D><F><M><E><T><T><D><Y><F><E><T><T><D><N><E><I><T><D><I><N><E><N><I><C><D><S><E><N><P><D><H><N><E><V><P><N><N><E><T><T><D><N><N><E><S><A><D><D><H><E><T><T><D><N><N><E><S><A><D><D><N><N><E><N><P><E><D><N><N><K><N><T><D><D><N><E><E><N><P><N><N><N><E><N><T><Y><G><N><N><F><F><K><G><G><F><W><G><S><H><G><N><N><Q><D><S><S><D><S><D><N><E><A><D><E><A><S><D><D><E><D><N><D><G><N><E><G><D><N><E><G><S><D><D><D><G><N><E><G><D><N><E><G><S><D><D><D><D><R><D><I><E><Y><Y><E><K><V><I><E><D><F><D><K><D><Q><A><D><Y><E><D><V><I><E><I><I><S><D><E><S><V><E><E><E><G><I><E><E><G><I><Q><Q><D><E><D><I><Y><E><E><G><N><Y><E><E><E><G><S><E><D><V><W><E><E><G><E><D><S><D><D><S><D><L><E><D><V><L><Q><V><P><N><G><W><A><N><P><G><K><R><G><K><T><G> | Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.<BOP> | Q9H2G4 |
Q9Y5Y4 | PD2R2_HUMAN | G-protein coupled receptor 44 | Homo | <M><S><A><N><A><T><L><K><P><L><C><P><I><L><E><Q><M><S><R><L><Q><S><H><S><N><T><S><I><R><Y><I><D><H><A><A><V><L><L><H><G><L><A><S><L><L><G><L><V><E><N><G><V><I><L><F><V><V><G><C><R><M><R><Q><T><V><V><T><T><W><V><L><H><L><A><L><S><D><L><L><A><S><A><S><L><P><F><F><T><Y><F><L><A><V><G><H><S><W><E><L><G><T><T><F><C><K><L><H><S><S><I><F><F><L><N><M><F><A><S><G><F><L><L><S><A><I><S><L><D><R><C><L><Q><V><V><R><P><V><W><A><Q><N><H><R><T><V><A><A><A><H><K><V><C><L><V><L><W><A><L><A><V><L><N><T><V><P><Y><F><V><F><R><D><T><I><S><R><L><D><G><R><I><M><C><Y><Y><N><V><L><L><L><N><P><G><P><D><R><D><A><T><C><N><S><R><Q><V><A><L><A><V><S><K><F><L><L><A><F><L><V><P><L><A><I><I><A><S><S><H><A><A><V><S><L><R><L><Q><H><R><G><R><R><R><P><G><R><F><V><R><L><V><A><A><V><V><A><A><F><A><L><C><W><G><P><Y><H><V><F><S><L><L><E><A><R><A><H><A><N><P><G><L><R><P><L><V><W><R><G><L><P><F><V><T><S><L><A><F><F><N><S><V><A><N><P><V><L><Y><V><L><T><C><P><D><M><L><R><K><L><R><R><S><L><R><T><V><L><E><S><V><L><V><D><D><S><E><L><G><G><A><G><S><S><R><R><R><R><T><S><S><T><A><R><S><A><S><P><L><A><L><C><S><R><P><E><E><P><R><G><P><A><R><L><L><G><W><L><L><G><S><C><A><A><S><P><Q><T><G><P><L><N><R><A><L><S><S><T><S><S> | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.<BOP> | Q9Y5Y4 |
Q15583 | TGIF1_HUMAN | 5'-TG-3'-interacting factor 1 | Homo | <M><V><L><A><Q><S><R><V><S><A><G><V><G><S><P><H><C><S><G><S><G><G><G><G><S><D><S><F><P><W><P><A><S><H><P><G><N><P><Q><C><S><F><S><T><A><F><L><A><S><P><R><L><S><R><G><T><L><A><Y><L><P><P><A><P><W><S><S><L><A><T><P><S><A><L><L><G><S><S><C><A><P><P><P><P><P><A><R><C><P><Q><P><R><A><L><S><P><E><L><G><T><K><A><G><P><R><R><P><H><R><W><E><L><P><R><S><P><S><Q><G><A><Q><G><P><A><P><R><R><R><L><L><E><T><M><K><G><I><V><A><A><S><G><S><E><T><E><D><E><D><S><M><D><I><P><L><D><L><S><S><S><A><G><S><G><K><R><R><R><R><G><N><L><P><K><E><S><V><Q><I><L><R><D><W><L><Y><E><H><R><Y><N><A><Y><P><S><E><Q><E><K><A><L><L><S><Q><Q><T><H><L><S><T><L><Q><V><C><N><W><F><I><N><A><R><R><R><L><L><P><D><M><L><R><K><D><G><K><D><P><N><Q><F><T><I><S><R><R><G><A><K><I><S><E><T><S><S><V><E><S><V><M><G><I><K><N><F><M><P><A><L><E><E><T><P><F><H><S><C><T><A><G><P><N><P><T><L><G><R><P><L><S><P><K><P><S><S><P><G><S><V><L><A><R><P><S><V><I><C><H><T><T><V><T><A><L><K><D><V><P><F><S><L><C><Q><S><V><G><V><G><Q><N><T><D><I><Q><Q><I><A><A><K><N><F><T><D><T><S><L><M><Y><P><E><D><T><C><K><S><G><P><S><T><N><T><Q><S><G><L><F><N><T><P><P><P><T><P><P><D><L><N><Q><D><F><S><G><F><Q><L><L><V><D><V><A><L><K><R><A><A><E><M><E><L><Q><A><K><L><T><A> | Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.<BOP> | Q15583 |
Q8NI32 | LPD6B_HUMAN | Ly6/PLAUR domain-containing protein 6B | Homo | <M><L><Y><K><S><S><D><R><P><A><H><K><V><S><M><L><L><L><C><H><A><L><A><I><A><V><V><Q><I><V><I><F><S><E><S><W><A><F><A><K><N><I><N><F><Y><N><V><R><P><P><L><D><P><T><P><F><P><N><S><F><K><C><F><T><C><E><N><A><G><D><N><Y><N><C><N><R><W><A><E><D><K><W><C><P><Q><N><T><Q><Y><C><L><T><V><H><H><F><T><S><H><G><R><S><T><S><I><T><K><K><C><A><S><R><S><E><C><H><F><V><G><C><H><H><S><R><D><S><E><H><T><E><C><R><S><C><C><E><G><M><I><C><N><V><E><L><P><T><N><H><T><N><A><V><F><A><V><M><H><A><Q><R><T><S><G><S><S><A><P><T><L><Y><L><P><V><L><A><W><V><F><V><L><P><L><L> | Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.<BOP> | Q8NI32 |
Q9Y462 | ZN711_HUMAN | Zinc finger protein 6 | Homo | <M><D><S><G><G><G><S><L><G><L><H><T><P><D><S><R><M><A><H><T><M><I><M><Q><D><F><V><A><G><M><A><G><T><A><H><I><D><G><D><H><I><V><V><S><V><P><E><A><V><L><V><S><D><V><V><T><D><D><G><I><T><L><D><H><G><L><A><A><E><V><V><H><G><P><D><I><I><T><E><T><D><V><V><T><E><G><V><I><V><P><E><A><V><L><E><A><D><V><A><I><E><E><D><L><E><E><D><D><G><D><H><I><L><T><S><E><L><I><T><E><T><V><R><V><P><E><Q><V><F><V><A><D><L><V><T><G><P><N><G><H><L><E><H><V><V><Q><D><C><V><S><G><V><D><S><P><T><M><V><S><E><E><V><L><V><T><N><S><D><T><E><T><V><I><Q><A><A><G><G><V><P><G><S><T><V><T><I><K><T><E><D><D><D><D><D><D><V><K><S><T><S><E><D><Y><L><M><I><S><L><D><D><V><G><E><K><L><E><H><M><G><N><T><P><L><K><I><G><S><D><G><S><Q><E><D><A><K><E><D><G><F><G><S><E><V><I><K><V><Y><I><F><K><A><E><A><E><D><D><V><E><I><G><G><T><E><I><V><T><E><S><E><Y><T><S><G><H><S><V><A><G><V><L><D><Q><S><R><M><Q><R><E><K><M><V><Y><M><A><V><K><D><S><S><Q><E><E><D><D><I><R><D><E><R><R><V><S><R><R><Y><E><D><C><Q><A><S><G><N><T><L><D><S><A><L><E><S><R><S><S><T><A><A><Q><Y><L><Q><I><C><D><G><I><N><T><N><K><V><L><K><Q><K><A><K><K><R><R><R><G><E><T><R><Q><W><Q><T><A><V><I><I><G><P><D><G><Q><P><L><T><V><Y><P><C><H><I><C><T><K><K><F><K><S><R><G><F><L><K><R><H><M><K><N><H><P><D><H><L><M><R><K><K><Y><Q><C><T><D><C><D><F><T><T><N><K><K><V><S><F><H><N><H><L><E><S><H><K><L><I><N><K><V><D><K><T><H><E><F><T><E><Y><T><R><R><Y><R><E><A><S><P><L><S><S><N><K><L><I><L><R><D><K><E><P><K><M><H><K><C><K><Y><C><D><Y><E><T><A><E><Q><G><L><L><N><R><H><L><L><A><V><H><S><K><N><F><P><H><V><C><V><E><C><G><K><G><F><R><H><P><S><E><L><K><K><H><M><R><T><H><T><G><E><K><P><Y><Q><C><Q><Y><C><I><F><R><C><A><D><Q><S><N><L><K><T><H><I><K><S><K><H><G><N><N><L><P><Y><K><C><E><H><C><P><Q><A><F><G><D><E><R><E><L><Q><R><H><L><D><L><F><Q><G><H><K><T><H><Q><C><P><H><C><D><H><K><S><T><N><S><S><D><L><K><R><H><I><I><S><V><H><T><K><D><F><P><H><K><C><E><V><C><D><K><G><F><H><R><P><S><E><L><K><K><H><S><D><I><H><K><G><R><K><I><H><Q><C><R><H><C><D><F><K><T><S><D><P><F><I><L><S><G><H><I><L><S><V><H><T><K><D><Q><P><L><K><C><K><R><C><K><R><G><F><R><Q><Q><N><E><L><K><K><H><M><K><T><H><T><G><R><K><I><Y><Q><C><E><Y><C><E><Y><S><T><T><D><A><S><G><F><K><R><H><V><I><S><I><H><T><K><D><Y><P><H><R><C><E><F><C><K><K><G><F><R><R><P><S><E><K><N><Q><H><I><M><R><H><H><K><E><A><L><M> | Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.<BOP> | Q9Y462 |
Q8IVH2 | FOXP4_HUMAN | Fork head-related protein-like A | Homo | <M><M><V><E><S><A><S><E><T><I><R><S><A><P><S><G><Q><N><G><V><G><S><L><S><G><Q><A><D><G><S><S><G><G><A><T><G><T><T><A><S><G><T><G><R><E><V><T><T><G><A><D><S><N><G><E><M><S><P><A><E><L><L><H><F><Q><Q><Q><Q><A><L><Q><V><A><R><Q><F><L><L><Q><Q><A><S><G><L><S><S><P><G><N><N><D><S><K><Q><S><A><S><A><V><Q><V><P><V><S><V><A><M><M><S><P><Q><M><L><T><P><Q><Q><M><Q><Q><I><L><S><P><P><Q><L><Q><A><L><L><Q><Q><Q><Q><A><L><M><L><Q><Q><L><Q><E><Y><Y><K><K><Q><Q><E><Q><L><H><L><Q><L><L><T><Q><Q><Q><A><G><K><P><Q><P><K><E><A><L><G><N><K><Q><L><A><F><Q><Q><Q><L><L><Q><M><Q><Q><L><Q><Q><Q><H><L><L><N><L><Q><R><Q><G><L><V><S><L><Q><P><N><Q><A><S><G><P><L><Q><T><L><P><Q><A><A><V><C><P><T><D><L><P><Q><L><W><K><G><E><G><A><P><G><Q><P><A><E><D><S><V><K><Q><E><G><L><D><L><T><G><T><A><A><T><A><T><S><F><A><A><P><P><K><V><S><P><P><L><S><H><H><T><L><P><N><G><Q><P><T><V><L><T><S><R><R><D><S><S><S><H><E><E><T><P><G><S><H><P><L><Y><G><H><G><E><C><K><W><P><G><C><E><T><L><C><E><D><L><G><Q><F><I><K><H><L><N><T><E><H><A><L><D><D><R><S><T><A><Q><C><R><V><Q><M><Q><V><V><Q><Q><L><E><I><Q><L><A><K><E><S><E><R><L><Q><A><M><M><A><H><L><H><M><R><P><S><E><P><K><P><F><S><Q><P><L><N><P><V><P><G><S><S><S><F><S><K><V><T><V><S><A><A><D><S><F><P><D><G><L><V><H><P><P><T><S><A><A><A><P><V><T><P><L><R><P><P><G><L><G><S><A><S><L><H><G><G><G><P><A><R><R><R><S><S><D><K><F><C><S><P><I><S><S><E><L><A><Q><N><H><E><F><Y><K><N><A><D><V><R><P><P><F><T><Y><A><S><L><I><R><Q><A><I><L><E><T><P><D><R><Q><L><T><L><N><E><I><Y><N><W><F><T><R><M><F><A><Y><F><R><R><N><T><A><T><W><K><N><A><V><R><H><N><L><S><L><H><K><C><F><V><R><V><E><N><V><K><G><A><V><W><T><V><D><E><R><E><Y><Q><K><R><R><P><P><K><M><T><G><S><P><T><L><V><K><N><M><I><S><G><L><S><Y><G><A><L><N><A><S><Y><Q><A><A><L><A><E><S><S><F><P><L><L><N><S><P><G><M><L><N><P><G><S><A><S><S><L><L><P><L><S><H><D><D><V><G><A><P><V><E><P><L><P><S><N><G><S><S><S><P><P><R><L><S><P><P><Q><Y><S><H><Q><V><Q><V><K><E><E><P><A><E><A><E><E><D><R><Q><P><G><P><P><L><G><A><P><N><P><S><A><S><G><P><P><E><D><R><D><L><E><E><E><L><P><G><E><E><L><S> | Transcriptional repressor that represses lung-specific expression.<BOP> | Q8IVH2 |
Q3LI81 | KR271_HUMAN | Keratin-associated protein 27-1 | Homo | <M><P><H><S><H><C><H><S><L><R><S><F><H><N><A><P><P><L><S><A><I><T><H><G><T><N><P><I><T><F><E><D><R><L><C><L><P><S><S><F><H><S><R><T><C><F><L><D><N><F><Q><E><T><C><N><E><T><T><S><C><Q><M><T><N><C><E><Q><D><L><F><T><D><D><S><C><V><Q><S><N><C><F><P><G><V><V><Q><T><T><Y><S><N><S><R><P><C><E><R><T><A><C><Q><S><E><S><S><S><A><G><L><A><C><V><S><Q><P><C><Q><S><E><S><T><Q><Q><M><G><F><V><A><Q><S><C><Q><P><A><S><L><K><G><N><S><C><P><P><K><T><S><K><S><K><N><F><E><T><L><E><R><A><S><S><Q><C><Q><C><Q><S><Q><N><P><E><S><S><S><C><R><P><L><V><N><V><A><P><E><P><Q><L><L><E><S><S><P><G><V><E><P><T><C><C><V><T><G><G><S><Q><L><P><S><K> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q3LI81 |
Q8TC76 | F110B_HUMAN | Protein FAM110B | Homo | <M><P><T><E><T><L><Q><T><G><S><M><V><K><P><V><S><P><A><G><T><F><T><S><A><V><P><L><R><I><L><N><K><G><P><D><Y><F><R><R><Q><A><E><P><N><P><K><R><L><S><A><V><E><R><L><E><A><D><K><A><K><Y><V><K><S><Q><E><V><I><N><A><K><Q><E><P><V><K><P><A><V><L><A><K><P><P><V><C><P><A><A><K><R><A><L><G><S><P><T><L><K><V><F><G><N><H><A><K><T><E><S><G><V><Q><R><E><N><L><K><L><E><I><L><K><N><I><I><N><S><S><E><G><S><S><S><G><S><G><H><K><H><S><S><R><N><W><P><P><H><R><S><E><A><T><D><L><H><R><H><S><F><A><E><S><L><K><V><Y><P><T><Q><G><R><R><S><P><Q><E><G><G><S><H><V><G><R><R><L><L><E><Q><S><A><E><S><F><L><H><V><S><H><S><S><S><D><I><R><K><V><T><S><V><K><P><L><K><A><I><P><C><S><S><S><A><P><P><L><P><P><K><P><K><I><A><A><I><A><S><M><K><S><P><E><A><D><P><V><E><P><A><C><G><V><S><R><R><P><S><L><Q><R><S><K><S><D><L><S><D><R><Y><F><R><V><D><A><D><V><E><R><F><F><N><Y><C><G><L><D><P><E><E><L><E><N><L><G><M><E><N><F><A><R><A><N><S><D><I><I><S><L><N><F><R><S><A><S><M><I><S><S><D><C><E><Q><S><Q><D><S><N><S><D><L><R><N><D><D><S><A><N><D><R><V><P><Y><G><I><S><A><I><E><R><N><A><R><I><I><K><W><L><Y><S><I><K><Q><A><R><E><S><Q><K><V><S><H><V> | May be involved in tumor progression.<BOP> | Q8TC76 |
P34947 | GRK5_HUMAN | G protein-coupled receptor kinase GRK5 | Homo | <M><E><L><E><N><I><V><A><N><T><V><L><L><K><A><R><E><G><G><G><G><K><R><K><G><K><S><K><K><W><K><E><I><L><K><F><P><H><I><S><Q><C><E><D><L><R><R><T><I><D><R><D><Y><C><S><L><C><D><K><Q><P><I><G><R><L><L><F><R><Q><F><C><E><T><R><P><G><L><E><C><Y><I><Q><F><L><D><S><V><A><E><Y><E><V><T><P><D><E><K><L><G><E><K><G><K><E><I><M><T><K><Y><L><T><P><K><S><P><V><F><I><A><Q><V><G><Q><D><L><V><S><Q><T><E><E><K><L><L><Q><K><P><C><K><E><L><F><S><A><C><A><Q><S><V><H><E><Y><L><R><G><E><P><F><H><E><Y><L><D><S><M><F><F><D><R><F><L><Q><W><K><W><L><E><R><Q><P><V><T><K><N><T><F><R><Q><Y><R><V><L><G><K><G><G><F><G><E><V><C><A><C><Q><V><R><A><T><G><K><M><Y><A><C><K><R><L><E><K><K><R><I><K><K><R><K><G><E><S><M><A><L><N><E><K><Q><I><L><E><K><V><N><S><Q><F><V><V><N><L><A><Y><A><Y><E><T><K><D><A><L><C><L><V><L><T><I><M><N><G><G><D><L><K><F><H><I><Y><N><M><G><N><P><G><F><E><E><E><R><A><L><F><Y><A><A><E><I><L><C><G><L><E><D><L><H><R><E><N><T><V><Y><R><D><L><K><P><E><N><I><L><L><D><D><Y><G><H><I><R><I><S><D><L><G><L><A><V><K><I><P><E><G><D><L><I><R><G><R><V><G><T><V><G><Y><M><A><P><E><V><L><N><N><Q><R><Y><G><L><S><P><D><Y><W><G><L><G><C><L><I><Y><E><M><I><E><G><Q><S><P><F><R><G><R><K><E><K><V><K><R><E><E><V><D><R><R><V><L><E><T><E><E><V><Y><S><H><K><F><S><E><E><A><K><S><I><C><K><M><L><L><T><K><D><A><K><Q><R><L><G><C><Q><E><E><G><A><A><E><V><K><R><H><P><F><F><R><N><M><N><F><K><R><L><E><A><G><M><L><D><P><P><F><V><P><D><P><R><A><V><Y><C><K><D><V><L><D><I><E><Q><F><S><T><V><K><G><V><N><L><D><H><T><D><D><D><F><Y><S><K><F><S><T><G><S><V><S><I><P><W><Q><N><E><M><I><E><T><E><C><F><K><E><L><N><V><F><G><P><N><G><T><L><P><P><D><L><N><R><N><H><P><P><E><P><P><K><K><G><L><L><Q><R><L><F><K><R><Q><H><Q><N><N><S><K><S><S><P><S><S><K><T><S><F><N><H><H><I><N><S><N><H><V><S><S><N><S><T><G><S><S> | Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis | P34947 |
Q8IVN3 | MSTN1_HUMAN | Musculoskeletal embryonic nuclear protein 1 | Homo | <M><S><Q><A><G><A><Q><E><A><P><I><K><K><K><R><P><P><V><K><D><E><D><L><K><G><A><R><G><N><L><T><K><N><Q><E><I><K><S><K><T><Y><Q><V><M><R><E><C><E><Q><A><G><S><A><A><P><S><V><F><S><R><T><R><T><G><T><E><T><V><F><E><K><P><K><A><G><P><T><K><S><V><F><G> | May be involved in the development and regeneration of the musculoskeletal system.<BOP> | Q8IVN3 |
P30305 | MPIP2_HUMAN | Dual specificity phosphatase Cdc25B | Homo | <M><E><V><P><Q><P><E><P><A><P><G><S><A><L><S><P><A><G><V><C><G><G><A><Q><R><P><G><H><L><P><G><L><L><L><G><S><H><G><L><L><G><S><P><V><R><A><A><A><S><S><P><V><T><T><L><T><Q><T><M><H><D><L><A><G><L><G><S><E><T><P><K><S><Q><V><G><T><L><L><F><R><S><R><S><R><L><T><H><L><S><L><S><R><R><A><S><E><S><S><L><S><S><E><S><S><E><S><S><D><A><G><L><C><M><D><S><P><S><P><M><D><P><H><M><A><E><Q><T><F><E><Q><A><I><Q><A><A><S><R><I><I><R><N><E><Q><F><A><I><R><R><F><Q><S><M><P><V><R><L><L><G><H><S><P><V><L><R><N><I><T><N><S><Q><A><P><D><G><R><R><K><S><E><A><G><S><G><A><A><S><S><S><G><E><D><K><E><N><D><G><F><V><F><K><M><P><W><K><P><T><H><P><S><S><T><H><A><L><A><E><W><A><S><R><R><E><A><F><A><Q><R><P><S><S><A><P><D><L><M><C><L><S><P><D><R><K><M><E><V><E><E><L><S><P><L><A><L><G><R><F><S><L><T><P><A><E><G><D><T><E><E><D><D><G><F><V><D><I><L><E><S><D><L><K><D><D><D><A><V><P><P><G><M><E><S><L><I><S><A><P><L><V><K><T><L><E><K><E><E><E><K><D><L><V><M><Y><S><K><C><Q><R><L><F><R><S><P><S><M><P><C><S><V><I><R><P><I><L><K><R><L><E><R><P><Q><D><R><D><T><P><V><Q><N><K><R><R><R><S><V><T><P><P><E><E><Q><Q><E><A><E><E><P><K><A><R><V><L><R><S><K><S><L><C><H><D><E><I><E><N><L><L><D><S><D><H><R><E><L><I><G><D><Y><S><K><A><F><L><L><Q><T><V><D><G><K><H><Q><D><L><K><Y><I><S><P><E><T><M><V><A><L><L><T><G><K><F><S><N><I><V><D><K><F><V><I><V><D><C><R><Y><P><Y><E><Y><E><G><G><H><I><K><T><A><V><N><L><P><L><E><R><D><A><E><S><F><L><L><K><S><P><I><A><P><C><S><L><D><K><R><V><I><L><I><F><H><C><E><F><S><S><E><R><G><P><R><M><C><R><F><I><R><E><R><D><R><A><V><N><D><Y><P><S><L><Y><Y><P><E><M><Y><I><L><K><G><G><Y><K><E><F><F><P><Q><H><P><N><F><C><E><P><Q><D><Y><R><P><M><N><H><E><A><F><K><D><E><L><K><T><F><R><L><K><T><R><S><W><A><G><E><R><S><R><R><E><L><C><S><R><L><Q><D><Q> | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<BOP> | P30305 |
O95684 | CEP43_HUMAN | FGFR1 oncogene partner | Homo | <M><A><A><T><A><A><A><V><V><A><E><E><D><T><E><L><R><D><L><L><V><Q><T><L><E><N><S><G><V><L><N><R><I><K><A><E><L><R><A><A><V><F><L><A><L><E><E><Q><E><K><V><E><N><K><T><P><L><V><N><E><S><L><K><K><F><L><N><T><K><D><G><R><L><V><A><S><L><V><A><E><F><L><Q><F><F><N><L><D><F><T><L><A><V><F><Q><P><E><T><S><T><L><Q><G><L><E><G><R><E><N><L><A><R><D><L><G><I><I><E><A><E><G><T><V><G><G><P><L><L><L><E><V><I><R><R><C><Q><Q><K><E><K><G><P><T><T><G><E><G><A><L><D><L><S><D><V><H><S><P><P><K><S><P><E><G><K><T><S><A><Q><T><T><P><S><K><I><P><R><Y><K><G><Q><G><K><K><K><T><S><G><Q><K><A><G><D><K><K><A><N><D><E><A><N><Q><S><D><T><S><V><S><L><S><E><P><K><S><K><S><S><L><H><L><L><S><H><E><T><K><I><G><S><F><L><S><N><R><T><L><D><G><K><D><K><A><G><L><C><P><D><E><D><D><M><E><G><D><S><F><F><D><D><P><I><P><K><P><E><K><T><Y><G><L><R><K><E><P><R><K><Q><A><G><S><L><A><S><L><S><D><A><P><P><L><K><S><G><L><S><S><L><A><G><A><P><S><L><K><D><S><E><S><K><R><G><N><T><V><L><K><D><L><K><L><I><S><D><K><I><G><S><L><G><L><G><T><G><E><D><D><D><Y><V><D><D><F><N><S><T><S><H><R><S><E><K><S><E><I><S><I><G><E><E><I><E><E><D><L><S><V><E><I><D><D><I><N><T><S><D><K><L><D><D><L><T><Q><D><L><T><V><S><Q><L><S><D><V><A><D><Y><L><E><D><V><A> | Required for anchoring microtubules to the centrosomes . Required for ciliation .<BOP> | O95684 |
P48146 | NPBW2_HUMAN | G-protein coupled receptor 8 | Homo | <M><Q><A><A><G><H><P><E><P><L><D><S><R><G><S><F><S><L><P><T><M><G><A><N><V><S><Q><D><N><G><T><G><H><N><A><T><F><S><E><P><L><P><F><L><Y><V><L><L><P><A><V><Y><S><G><I><C><A><V><G><L><T><G><N><T><A><V><I><L><V><I><L><R><A><P><K><M><K><T><V><T><N><V><F><I><L><N><L><A><V><A><D><G><L><F><T><L><V><L><P><V><N><I><A><E><H><L><L><Q><Y><W><P><F><G><E><L><L><C><K><L><V><L><A><V><D><H><Y><N><I><F><S><S><I><Y><F><L><A><V><M><S><V><D><R><Y><L><V><V><L><A><T><V><R><S><R><H><M><P><W><R><T><Y><R><G><A><K><V><A><S><L><C><V><W><L><G><V><T><V><L><V><L><P><F><F><S><F><A><G><V><Y><S><N><E><L><Q><V><P><S><C><G><L><S><F><P><W><P><E><Q><V><W><F><K><A><S><R><V><Y><T><L><V><L><G><F><V><L><P><V><C><T><I><C><V><L><Y><T><D><L><L><R><R><L><R><A><V><R><L><R><S><G><A><K><A><L><G><K><A><R><R><K><V><T><V><L><V><L><V><V><L><A><V><C><L><L><C><W><T><P><F><H><L><A><S><V><V><A><L><T><T><D><L><P><Q><T><P><L><V><I><S><M><S><Y><V><I><T><S><L><S><Y><A><N><S><C><L><N><P><F><L><Y><A><F><L><D><D><N><F><R><K><N><F><R><S><I><L><R><C> | Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.<BOP> | P48146 |
Q9H069 | DRC3_HUMAN | Leucine-rich repeat-containing protein 48 | Homo | <M><N><Q><P><C><N><S><M><E><P><R><V><M><D><D><D><M><L><K><L><A><V><G><D><Q><G><P><Q><E><E><A><G><Q><L><A><K><Q><E><G><I><L><F><K><D><V><L><S><L><Q><L><D><F><R><N><I><L><R><I><D><N><L><W><Q><F><E><N><L><R><K><L><Q><L><D><N><N><I><I><E><K><I><E><G><L><E><N><L><A><H><L><V><W><L><D><L><S><F><N><N><I><E><T><I><E><G><L><D><T><L><V><N><L><E><D><L><S><L><F><N><N><R><I><S><K><I><D><S><L><D><A><L><V><K><L><Q><V><L><S><L><G><N><N><R><I><D><N><M><M><N><I><I><Y><L><R><R><F><K><C><L><R><T><L><S><L><S><R><N><P><I><S><E><A><E><D><Y><K><M><F><I><C><A><Y><L><P><D><L><M><Y><L><D><Y><R><R><I><D><D><H><T><K><K><L><A><E><A><K><H><Q><Y><S><I><D><E><L><K><H><Q><E><N><L><M><Q><A><Q><L><E><D><E><Q><A><Q><R><E><E><L><E><K><H><K><T><A><F><V><E><H><L><N><G><S><F><L><F><D><S><M><Y><A><E><D><S><E><G><N><N><L><S><Y><L><P><G><V><G><E><L><L><E><T><Y><K><D><K><F><V><I><I><C><V><N><I><F><E><Y><G><L><K><Q><Q><E><K><R><K><T><E><L><D><T><F><S><E><C><V><R><E><A><I><Q><E><N><Q><E><Q><G><K><R><K><I><A><K><F><E><E><K><H><L><S><S><L><S><A><I><R><E><E><L><E><L><P><N><I><E><K><M><I><L><E><C><S><A><D><I><S><E><L><F><D><A><L><M><T><L><E><M><Q><L><V><E><Q><L><E><E><T><I><N><M><F><E><R><N><I><V><D><M><V><G><L><F><I><E><N><V><Q><S><L><M><A><Q><C><R><D><L><E><N><H><H><H><E><K><L><L><E><I><S><I><S><T><L><E><K><I><V><E><G><D><L><D><E><D><L><P><N><D><L><R><A><L><F><V><D><K><D><T><I><V><N><A><V><G><A><S><H><D><I><H><L><L><K><I><D><N><R><E><D><E><L><V><T><R><I><N><S><W><C><T><R><L><I><D><R><I><H><K><D><E><I><M><R><N><R><K><R><V><K><E><I><N><Q><Y><I><D><H><M><Q><S><E><L><D><N><L><E><C><G><D><I><L><D> | Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.<BOP> | Q9H069 |
P47898 | 5HT5A_HUMAN | Serotonin receptor 5A | Homo | <M><D><L><P><V><N><L><T><S><F><S><L><S><T><P><S><P><L><E><T><N><H><S><L><G><K><D><D><L><R><P><S><S><P><L><L><S><V><F><G><V><L><I><L><T><L><L><G><F><L><V><A><A><T><F><A><W><N><L><L><V><L><A><T><I><L><R><V><R><T><F><H><R><V><P><H><N><L><V><A><S><M><A><V><S><D><V><L><V><A><A><L><V><M><P><L><S><L><V><H><E><L><S><G><R><R><W><Q><L><G><R><R><L><C><Q><L><W><I><A><C><D><V><L><C><C><T><A><S><I><W><N><V><T><A><I><A><L><D><R><Y><W><S><I><T><R><H><M><E><Y><T><L><R><T><R><K><C><V><S><N><V><M><I><A><L><T><W><A><L><S><A><V><I><S><L><A><P><L><L><F><G><W><G><E><T><Y><S><E><G><S><E><E><C><Q><V><S><R><E><P><S><Y><A><V><F><S><T><V><G><A><F><Y><L><P><L><C><V><V><L><F><V><Y><W><K><I><Y><K><A><A><K><F><R><V><G><S><R><K><T><N><S><V><S><P><I><S><E><A><V><E><V><K><D><S><A><K><Q><P><Q><M><V><F><T><V><R><H><A><T><V><T><F><Q><P><E><G><D><T><W><R><E><Q><K><E><Q><R><A><A><L><M><V><G><I><L><I><G><V><F><V><L><C><W><I><P><F><F><L><T><E><L><I><S><P><L><C><S><C><D><I><P><A><I><W><K><S><I><F><L><W><L><G><Y><S><N><S><F><F><N><P><L><I><Y><T><A><F><N><K><N><Y><N><S><A><F><K><N><F><F><S><R><Q><H> | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.<BOP> | P47898 |
Q9H4I9 | EMRE_HUMAN | Single-pass membrane protein with aspartate-rich tail 1, mitochondrial | Homo | <M><A><S><G><A><A><R><W><L><V><L><A><P><V><R><S><G><A><L><R><S><G><P><S><L><R><K><D><G><D><V><S><A><A><W><S><G><S><G><R><S><L><V><P><S><R><S><V><I><V><T><R><S><G><A><I><L><P><K><P><V><K><M><S><F><G><L><L><R><V><F><S><I><V><I><P><F><L><Y><V><G><T><L><I><S><K><N><F><A><A><L><L><E><E><H><D><I><F><V><P><E><D><D><D><D><D><D> | Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria . Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU . Plays a central role in regulating the uniplex complex response to intracellular calcium signaling . Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling .<BOP> | Q9H4I9 |
Q07021 | C1QBP_HUMAN | p33 | Homo | <M><L><P><L><L><R><C><V><P><R><V><L><G><S><S><V><A><G><L><R><A><A><A><P><A><S><P><F><R><Q><L><L><Q><P><A><P><R><L><C><T><R><P><F><G><L><L><S><V><R><A><G><S><E><R><R><P><G><L><L><R><P><R><G><P><C><A><C><G><C><G><C><G><S><L><H><T><D><G><D><K><A><F><V><D><F><L><S><D><E><I><K><E><E><R><K><I><Q><K><H><K><T><L><P><K><M><S><G><G><W><E><L><E><L><N><G><T><E><A><K><L><V><R><K><V><A><G><E><K><I><T><V><T><F><N><I><N><N><S><I><P><P><T><F><D><G><E><E><E><P><S><Q><G><Q><K><V><E><E><Q><E><P><E><L><T><S><T><P><N><F><V><V><E><V><I><K><N><D><D><G><K><K><A><L><V><L><D><C><H><Y><P><E><D><E><V><G><Q><E><D><E><A><E><S><D><I><F><S><I><R><E><V><S><F><Q><S><T><G><E><S><E><W><K><D><T><N><Y><T><L><N><T><D><S><L><D><W><A><L><Y><D><H><L><M><D><F><L><A><D><R><G><V><D><N><T><F><A><D><E><L><V><E><L><S><T><A><L><E><H><Q><E><Y><I><T><F><L><E><D><L><K><S><F><V><K><S><Q> | (Microbial infection) Involved in replication of Rubella virus.<BOP> | Q07021 |
Q9Y2T2 | AP3M1_HUMAN | Mu3A-adaptin | Homo | <M><I><H><S><L><F><L><I><N><C><S><G><D><I><F><L><E><K><H><W><K><S><V><V><S><Q><S><V><C><D><Y><F><F><E><A><Q><E><K><A><A><D><V><E><N><V><P><P><V><I><S><T><P><H><H><Y><L><I><S><I><Y><R><D><K><L><F><F><V><S><V><I><Q><T><E><V><P><P><L><F><V><I><E><F><L><H><R><V><A><D><T><F><Q><D><Y><F><G><E><C><S><E><A><A><I><K><D><N><V><V><I><V><Y><E><L><L><E><E><M><L><D><N><G><F><P><L><A><T><E><S><N><I><L><K><E><L><I><K><P><P><T><I><L><R><S><V><V><N><S><I><T><G><S><S><N><V><G><D><T><L><P><T><G><Q><L><S><N><I><P><W><R><R><A><G><V><K><Y><T><N><N><E><A><Y><F><D><V><V><E><E><I><D><A><I><I><D><K><S><G><S><T><V><F><A><E><I><Q><G><V><I><D><A><C><I><K><L><S><G><M><P><D><L><S><L><S><F><M><N><P><R><L><L><D><D><V><S><F><H><P><C><I><R><F><K><R><W><E><S><E><R><V><L><S><F><I><P><P><D><G><N><F><R><L><I><S><Y><R><V><S><S><Q><N><L><V><A><I><P><V><Y><V><K><H><S><I><S><F><K><E><N><S><S><C><G><R><F><D><I><T><I><G><P><K><Q><N><M><G><K><T><I><E><G><I><T><V><T><V><H><M><P><K><V><V><L><N><M><N><L><T><P><T><Q><G><S><Y><T><F><D><P><V><T><K><V><L><T><W><D><V><G><K><I><T><P><Q><K><L><P><S><L><K><G><L><V><N><L><Q><S><G><A><P><K><P><E><E><N><P><S><L><N><I><Q><F><K><I><Q><Q><L><A><I><S><G><L><K><V><N><R><L><D><M><Y><G><E><K><Y><K><P><F><K><G><V><K><Y><V><T><K><A><G><K><F><Q><V><R><T> | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.<BOP> | Q9Y2T2 |
P31277 | HXD11_HUMAN | Homeobox protein Hox-4F | Homo | <M><N><D><F><D><E><C><G><Q><S><A><A><S><M><Y><L><P><G><C><A><Y><Y><V><A><P><S><D><F><A><S><K><P><S><F><L><S><Q><P><S><S><C><Q><M><T><F><P><Y><S><S><N><L><A><P><H><V><Q><P><V><R><E><V><A><F><R><D><Y><G><L><E><R><A><K><W><P><Y><R><G><G><G><G><G><G><S><A><G><G><G><S><S><G><G><G><P><G><G><G><G><G><G><A><G><G><Y><A><P><Y><Y><A><A><A><A><A><A><A><A><A><A><A><A><A><E><E><A><A><M><Q><R><E><L><L><P><P><A><G><R><R><P><D><V><L><F><K><A><P><E><P><V><C><A><A><P><G><P><P><H><G><P><A><G><A><A><S><N><F><Y><S><A><V><G><R><N><G><I><L><P><Q><G><F><D><Q><F><Y><E><A><A><P><G><P><P><F><A><G><P><Q><P><P><P><P><P><A><P><P><Q><P><E><G><A><A><D><K><G><D><P><R><T><G><A><G><G><G><G><G><S><P><C><T><K><A><T><P><G><S><E><P><K><G><A><A><E><G><S><G><G><D><G><E><G><P><P><G><E><A><G><A><E><K><S><S><S><A><V><A><P><Q><R><S><R><K><K><R><C><P><Y><T><K><Y><Q><I><R><E><L><E><R><E><F><F><F><N><V><Y><I><N><K><E><K><R><L><Q><L><S><R><M><L><N><L><T><D><R><Q><V><K><I><W><F><Q><N><R><R><M><K><E><K><K><L><N><R><D><R><L><Q><Y><F><T><G><N><P><L><F> | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP> | P31277 |
P04234 | CD3D_HUMAN | T-cell receptor T3 delta chain | Homo | <M><E><H><S><T><F><L><S><G><L><V><L><A><T><L><L><S><Q><V><S><P><F><K><I><P><I><E><E><L><E><D><R><V><F><V><N><C><N><T><S><I><T><W><V><E><G><T><V><G><T><L><L><S><D><I><T><R><L><D><L><G><K><R><I><L><D><P><R><G><I><Y><R><C><N><G><T><D><I><Y><K><D><K><E><S><T><V><Q><V><H><Y><R><M><C><Q><S><C><V><E><L><D><P><A><T><V><A><G><I><I><V><T><D><V><I><A><T><L><L><L><A><L><G><V><F><C><F><A><G><H><E><T><G><R><L><S><G><A><A><D><T><Q><A><L><L><R><N><D><Q><V><Y><Q><P><L><R><D><R><D><D><A><Q><Y><S><H><L><G><G><N><W><A><R><N><K> | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways . In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.<BOP> | P04234 |
A0A0K0K1D8 | TVB61_HUMAN | T cell receptor beta variable 6-1 | Homo | <M><S><I><G><L><L><C><C><V><A><F><S><L><L><W><A><S><P><V><N><A><G><V><T><Q><T><P><K><F><Q><V><L><K><T><G><Q><S><M><T><L><Q><C><A><Q><D><M><N><H><N><S><M><Y><W><Y><R><Q><D><P><G><M><G><L><R><L><I><Y><Y><S><A><S><E><G><T><T><D><K><G><E><V><P><N><G><Y><N><V><S><R><L><N><K><R><E><F><S><L><R><L><E><S><A><A><P><S><Q><T><S><V><Y><F><C><A><S><S><E> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0K0K1D8 |
O00421 | CCRL2_HUMAN | Putative MCP-1 chemokine receptor | Homo | <M><A><N><Y><T><L><A><P><E><D><E><Y><D><V><L><I><E><G><E><L><E><S><D><E><A><E><Q><C><D><K><Y><D><A><Q><A><L><S><A><Q><L><V><P><S><L><C><S><A><V><F><V><I><G><V><L><D><N><L><L><V><V><L><I><L><V><K><Y><K><G><L><K><R><V><E><N><I><Y><L><L><N><L><A><V><S><N><L><C><F><L><L><T><L><P><F><W><A><H><A><G><G><D><P><M><C><K><I><L><I><G><L><Y><F><V><G><L><Y><S><E><T><F><F><N><C><L><L><T><V><Q><R><Y><L><V><F><L><H><K><G><N><F><F><S><A><R><R><R><V><P><C><G><I><I><T><S><V><L><A><W><V><T><A><I><L><A><T><L><P><E><F><V><V><Y><K><P><Q><M><E><D><Q><K><Y><K><C><A><F><S><R><T><P><F><L><P><A><D><E><T><F><W><K><H><F><L><T><L><K><M><N><I><S><V><L><V><L><P><L><F><I><F><T><F><L><Y><V><Q><M><R><K><T><L><R><F><R><E><Q><R><Y><S><L><F><K><L><V><F><A><I><M><V><V><F><L><L><M><W><A><P><Y><N><I><A><F><F><L><S><T><F><K><E><H><F><S><L><S><D><C><K><S><S><Y><N><L><D><K><S><V><H><I><T><K><L><I><A><T><T><H><C><C><I><N><P><L><L><Y><A><F><L><D><G><T><F><S><K><Y><L><C><R><C><F><H><L><R><S><N><T><P><L><Q><P><R><G><Q><S><A><Q><G><T><S><R><E><E><P><D><H><S><T><E><V> | Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.<BOP> | O00421 |
Q8TBC4 | UBA3_HUMAN | Ubiquitin-like modifier-activating enzyme 3 | Homo | <M><A><D><G><E><E><P><E><K><K><R><R><R><I><E><E><L><L><A><E><K><M><A><V><D><G><G><C><G><D><T><G><D><W><E><G><R><W><N><H><V><K><K><F><L><E><R><S><G><P><F><T><H><P><D><F><E><P><S><T><E><S><L><Q><F><L><L><D><T><C><K><V><L><V><I><G><A><G><G><L><G><C><E><L><L><K><N><L><A><L><S><G><F><R><Q><I><H><V><I><D><M><D><T><I><D><V><S><N><L><N><R><Q><F><L><F><R><P><K><D><I><G><R><P><K><A><E><V><A><A><E><F><L><N><D><R><V><P><N><C><N><V><V><P><H><F><N><K><I><Q><D><F><N><D><T><F><Y><R><Q><F><H><I><I><V><C><G><L><D><S><I><I><A><R><R><W><I><N><G><M><L><I><S><L><L><N><Y><E><D><G><V><L><D><P><S><S><I><V><P><L><I><D><G><G><T><E><G><F><K><G><N><A><R><V><I><L><P><G><M><T><A><C><I><E><C><T><L><E><L><Y><P><P><Q><V><N><F><P><M><C><T><I><A><S><M><P><R><L><P><E><H><C><I><E><Y><V><R><M><L><Q><W><P><K><E><Q><P><F><G><E><G><V><P><L><D><G><D><D><P><E><H><I><Q><W><I><F><Q><K><S><L><E><R><A><S><Q><Y><N><I><R><G><V><T><Y><R><L><T><Q><G><V><V><K><R><I><I><P><A><V><A><S><T><N><A><V><I><A><A><V><C><A><T><E><V><F><K><I><A><T><S><A><Y><I><P><L><N><N><Y><L><V><F><N><D><V><D><G><L><Y><T><Y><T><F><E><A><E><R><K><E><N><C><P><A><C><S><Q><L><P><Q><N><I><Q><F><S><P><S><A><K><L><Q><E><V><L><D><Y><L><T><N><S><A><S><L><Q><M><K><S><P><A><I><T><A><T><L><E><G><K><N><R><T><L><Y><L><Q><S><V><T><S><I><E><E><R><T><R><P><N><L><S><K><T><L><K><E><L><G><L><V><D><G><Q><E><L><A><V><A><D><V><T><T><P><Q><T><V><L><F><K><L><H><F><T><S> | Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.<BOP> | Q8TBC4 |
Q9Y3D6 | FIS1_HUMAN | Tetratricopeptide repeat protein 11 | Homo | <M><E><A><V><L><N><E><L><V><S><V><E><D><L><L><K><F><E><K><K><F><Q><S><E><K><A><A><G><S><V><S><K><S><T><Q><F><E><Y><A><W><C><L><V><R><S><K><Y><N><D><D><I><R><K><G><I><V><L><L><E><E><L><L><P><K><G><S><K><E><E><Q><R><D><Y><V><F><Y><L><A><V><G><N><Y><R><L><K><E><Y><E><K><A><L><K><Y><V><R><G><L><L><Q><T><E><P><Q><N><N><Q><A><K><E><L><E><R><L><I><D><K><A><M><K><K><D><G><L><V><G><M><A><I><V><G><G><M><A><L><G><V><A><G><L><A><G><L><I><G><L><A><V><S><K><S><K><S> | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.<BOP> | Q9Y3D6 |
P61580 | NP10_HUMAN | HERV-K_5q33.3 provirus Np9 protein | Homo | <M><N><P><S><E><M><Q><R><K><G><P><P><R><R><W><C><L><Q><V><Y><P><T><A><P><K><R><Q><R><P><S><R><T><G><H><D><D><D><G><G><F><V><E><K><K><R><G><K><C><G><E><K><Q><E><R><S><N><C><Y><C><V><C><V><E><R><S><R><H><R><R><L><H><F><V><M><C> | May possess a function in tumorigenesis.<BOP> | P61580 |
Q7Z6A9 | BTLA_HUMAN | B- and T-lymphocyte-associated protein | Homo | <M><K><T><L><P><A><M><L><G><T><G><K><L><F><W><V><F><F><L><I><P><Y><L><D><I><W><N><I><H><G><K><E><S><C><D><V><Q><L><Y><I><K><R><Q><S><E><H><S><I><L><A><G><D><P><F><E><L><E><C><P><V><K><Y><C><A><N><R><P><H><V><T><W><C><K><L><N><G><T><T><C><V><K><L><E><D><R><Q><T><S><W><K><E><E><K><N><I><S><F><F><I><L><H><F><E><P><V><L><P><N><D><N><G><S><Y><R><C><S><A><N><F><Q><S><N><L><I><E><S><H><S><T><T><L><Y><V><T><D><V><K><S><A><S><E><R><P><S><K><D><E><M><A><S><R><P><W><L><L><Y><R><L><L><P><L><G><G><L><P><L><L><I><T><T><C><F><C><L><F><C><C><L><R><R><H><Q><G><K><Q><N><E><L><S><D><T><A><G><R><E><I><N><L><V><D><A><H><L><K><S><E><Q><T><E><A><S><T><R><Q><N><S><Q><V><L><L><S><E><T><G><I><Y><D><N><D><P><D><L><C><F><R><M><Q><E><G><S><E><V><Y><S><N><P><C><L><E><E><N><K><P><G><I><V><Y><A><S><L><N><H><S><V><I><G><P><N><S><R><L><A><R><N><V><K><E><A><P><T><E><Y><A><S><I><C><V><R><S> | Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 . May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 . In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells .<BOP> | Q7Z6A9 |
Q86UT8 | CATAC_HUMAN | Coiled-coil domain-containing protein 84 | Homo | <M><A><P><A><Q><R><C><P><L><C><R><Q><T><F><F><C><G><R><G><H><V><Y><S><R><K><H><Q><R><Q><L><K><E><A><L><E><R><L><L><P><Q><V><E><A><A><R><K><A><I><R><A><A><Q><V><E><R><Y><V><P><E><H><E><R><C><C><W><C><L><C><C><G><C><E><V><R><E><H><L><S><H><G><N><L><T><V><L><Y><G><G><L><L><E><H><L><A><S><P><E><H><K><K><A><T><N><K><F><W><W><E><N><K><A><E><V><Q><M><K><E><K><F><L><V><T><P><Q><D><Y><A><R><F><K><K><S><M><V><K><G><L><D><S><Y><E><E><K><E><D><K><V><I><K><E><M><A><A><Q><I><R><E><V><E><Q><S><R><Q><E><V><V><R><S><V><L><E><P><Q><A><V><P><D><P><E><E><G><S><S><A><P><R><S><W><K><G><M><N><S><Q><V><A><S><S><L><Q><Q><P><S><N><L><D><L><P><P><A><P><E><L><D><W><M><E><T><G><P><S><L><T><F><I><G><H><Q><D><I><P><G><V><G><N><I><H><S><G><A><T><P><P><W><M><I><Q><D><E><E><Y><I><A><G><N><Q><E><I><G><P><S><Y><E><E><F><L><K><E><K><E><K><Q><K><L><K><K><L><P><P><D><R><V><G><A><N><F><D><H><S><S><R><T><S><A><G><W><L><P><S><F><G><R><V><W><N><N><G><R><R><W><Q><S><R><H><Q><F><K><T><E><A><A><A><M><K><K><Q><S><H><T><E><K><S> | Negative regulator of centrosome duplication . Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 .<BOP> | Q86UT8 |
A5PLL7 | PDES1_HUMAN | Transmembrane protein 189 | Homo | <M><A><G><A><E><N><W><P><G><Q><Q><L><E><L><D><E><D><E><A><S><C><C><R><W><G><A><Q><H><A><G><A><R><E><L><A><A><L><Y><S><P><G><K><R><L><Q><E><W><C><S><V><I><L><C><F><S><L><I><A><H><N><L><V><H><L><L><L><L><A><R><W><E><D><T><P><L><V><I><L><G><V><V><A><G><A><L><I><A><D><F><L><S><G><L><V><H><W><G><A><D><T><W><G><S><V><E><L><P><I><V><G><K><A><F><I><R><P><F><R><E><H><H><I><D><P><T><A><I><T><R><H><D><F><I><E><T><N><G><D><N><C><L><V><T><L><L><P><L><L><N><M><A><Y><K><F><R><T><H><S><P><E><A><L><E><Q><L><Y><P><W><E><C><F><V><F><C><L><I><I><F><G><T><F><T><N><Q><I><H><K><W><S><H><T><Y><F><G><L><P><R><W><V><T><L><L><Q><D><W><H><V><I><L><P><R><K><H><H><R><I><H><H><V><S><P><H><E><T><Y><F><C><I><T><T><G><W><L><N><Y><P><L><E><K><I><G><F><W><R><R><L><E><D><L><I><Q><G><L><T><G><E><K><P><R><A><D><D><M><K><W><A><Q><K><I><K> | Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane . Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms .<BOP> | A5PLL7 |
P0DJD3 | RBY1A_HUMAN | Y chromosome RNA recognition motif 1 | Homo | <M><V><E><A><D><H><P><G><K><L><F><I><G><G><L><N><R><E><T><N><E><K><M><L><K><A><V><F><G><K><H><G><P><I><S><E><V><L><L><I><K><D><R><T><S><K><S><R><G><F><A><F><I><T><F><E><N><P><A><D><A><K><N><A><A><K><D><M><N><G><K><S><L><H><G><K><A><I><K><V><E><Q><A><K><K><P><S><F><Q><S><G><G><R><R><R><P><P><A><S><S><R><N><R><S><P><S><G><S><L><R><S><A><R><G><S><R><G><G><T><R><G><W><L><P><S><H><E><G><H><L><D><D><G><G><Y><T><P><D><L><K><M><S><Y><S><R><G><L><I><P><V><K><R><G><P><S><S><R><S><G><G><P><P><P><K><K><S><A><P><S><A><V><A><R><S><N><S><W><M><G><S><Q><G><P><M><S><Q><R><R><E><N><Y><G><V><P><P><R><R><A><T><I><S><S><W><R><N><D><R><M><S><T><R><H><D><G><Y><A><T><N><D><G><N><H><P><S><C><Q><E><T><R><D><Y><A><P><P><S><R><G><Y><A><Y><R><D><N><G><H><S><N><R><D><E><H><S><S><R><G><Y><R><N><H><R><S><S><R><E><T><R><D><Y><A><P><P><S><R><G><H><A><Y><R><D><Y><G><H><S><R><R><D><E><S><Y><S><R><G><Y><R><N><R><R><S><S><R><E><T><R><E><Y><A><P><P><S><R><G><H><G><Y><R><D><Y><G><H><S><R><R><H><E><S><Y><S><R><G><Y><R><N><H><P><S><S><R><E><T><R><D><Y><A><P><P><H><R><D><Y><A><Y><R><D><Y><G><H><S><S><W><D><E><H><S><S><R><G><Y><S><Y><H><D><G><Y><G><E><A><L><G><R><D><H><S><E><H><L><S><G><S><S><Y><R><D><A><L><Q><R><Y><G><T><S><H><G><A><P><P><A><R><G><P><R><M><S><Y><G><G><S><T><C><H><A><Y><S><N><T><R><D><R><Y><G><R><S><W><E><S><Y><S><S><C><G><D><F><H><Y><C><D><R><E><H><V><C><R><K><D><Q><R><N><P><P><S><L><G><R><V><L><P><D><P><R><E><A><C><G><S><S><S><Y><V><A><S><I><V><D><G><G><E><S><R><S><E><K><G><D><S><S><R><Y> | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.<BOP> | P0DJD3 |
P24723 | KPCL_HUMAN | nPKC-eta | Homo | <M><S><S><G><T><M><K><F><N><G><Y><L><R><V><R><I><G><E><A><V><G><L><Q><P><T><R><W><S><L><R><H><S><L><F><K><K><G><H><Q><L><L><D><P><Y><L><T><V><S><V><D><Q><V><R><V><G><Q><T><S><T><K><Q><K><T><N><K><P><T><Y><N><E><E><F><C><A><N><V><T><D><G><G><H><L><E><L><A><V><F><H><E><T><P><L><G><Y><D><H><F><V><A><N><C><T><L><Q><F><Q><E><L><L><R><T><T><G><A><S><D><T><F><E><G><W><V><D><L><E><P><E><G><K><V><F><V><V><I><T><L><T><G><S><F><T><E><A><T><L><Q><R><D><R><I><F><K><H><F><T><R><K><R><Q><R><A><M><R><R><R><V><H><Q><I><N><G><H><K><F><M><A><T><Y><L><R><Q><P><T><Y><C><S><H><C><R><E><F><I><W><G><V><F><G><K><Q><G><Y><Q><C><Q><V><C><T><C><V><V><H><K><R><C><H><H><L><I><V><T><A><C><T><C><Q><N><N><I><N><K><V><D><S><K><I><A><E><Q><R><F><G><I><N><I><P><H><K><F><S><I><H><N><Y><K><V><P><T><F><C><D><H><C><G><S><L><L><W><G><I><M><R><Q><G><L><Q><C><K><I><C><K><M><N><V><H><I><R><C><Q><A><N><V><A><P><N><C><G><V><N><A><V><E><L><A><K><T><L><A><G><M><G><L><Q><P><G><N><I><S><P><T><S><K><L><V><S><R><S><T><L><R><R><Q><G><K><E><S><S><K><E><G><N><G><I><G><V><N><S><S><N><R><L><G><I><D><N><F><E><F><I><R><V><L><G><K><G><S><F><G><K><V><M><L><A><R><V><K><E><T><G><D><L><Y><A><V><K><V><L><K><K><D><V><I><L><Q><D><D><D><V><E><C><T><M><T><E><K><R><I><L><S><L><A><R><N><H><P><F><L><T><Q><L><F><C><C><F><Q><T><P><D><R><L><F><F><V><M><E><F><V><N><G><G><D><L><M><F><H><I><Q><K><S><R><R><F><D><E><A><R><A><R><F><Y><A><A><E><I><I><S><A><L><M><F><L><H><D><K><G><I><I><Y><R><D><L><K><L><D><N><V><L><L><D><H><E><G><H><C><K><L><A><D><F><G><M><C><K><E><G><I><C><N><G><V><T><T><A><T><F><C><G><T><P><D><Y><I><A><P><E><I><L><Q><E><M><L><Y><G><P><A><V><D><W><W><A><M><G><V><L><L><Y><E><M><L><C><G><H><A><P><F><E><A><E><N><E><D><D><L><F><E><A><I><L><N><D><E><V><V><Y><P><T><W><L><H><E><D><A><T><G><I><L><K><S><F><M><T><K><N><P><T><M><R><L><G><S><L><T><Q><G><G><E><H><A><I><L><R><H><P><F><F><K><E><I><D><W><A><Q><L><N><H><R><Q><I><E><P><P><F><R><P><R><I><K><S><R><E><D><V><S><N><F><D><P><D><F><I><K><E><E><P><V><L><T><P><I><D><E><G><H><L><P><M><I><N><Q><D><E><F><R><N><F><S><Y><V><S><P><E><L><Q><P> | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly | P24723 |
Q96DD0 | LRC39_HUMAN | Myosin-interacting M-band-associated stress-responsive protein | Homo | <M><T><E><N><V><V><C><T><G><A><V><N><A><V><K><E><V><W><E><K><R><I><K><K><L><N><E><D><L><K><R><E><K><E><F><Q><H><K><L><V><R><I><W><E><E><R><V><S><L><T><K><L><R><E><K><V><T><R><E><D><G><R><V><I><L><K><I><E><K><E><E><W><K><T><L><P><S><S><L><L><K><L><N><Q><L><Q><E><W><Q><L><H><R><T><G><L><L><K><I><P><E><F><I><G><R><F><Q><N><L><I><V><L><D><L><S><R><N><T><I><S><E><I><P><P><G><I><G><L><L><T><R><L><Q><E><L><I><L><S><Y><N><K><I><K><T><V><P><K><E><L><S><N><C><A><S><L><E><K><L><E><L><A><V><N><R><D><I><C><D><L><P><Q><E><L><S><N><L><L><K><L><T><H><L><D><L><S><M><N><D><F><T><T><I><P><L><A><V><L><N><M><P><A><L><E><W><L><D><M><G><S><N><K><L><E><Q><L><P><D><T><I><E><R><M><Q><N><L><H><T><L><W><L><Q><R><N><E><I><T><C><L><P><Q><T><I><S><N><M><K><N><L><G><T><L><V><L><S><N><N><K><L><Q><D><I><P><V><C><M><E><E><M><A><N><L><R><F><V><N><F><R><D><N><P><L><K><L><K><V><S><L><P><P><S><E><G><T><D><E><E><E><E><R><E><L><F><G><L><Q><F><M><H><T><Y><I><Q><E><S><R><R><R><A><D><H><Q><V><N><G><S><T><T><L><P><I><S><I><N><T><D><G> | Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.<BOP> | Q96DD0 |
O95139 | NDUB6_HUMAN | NADH-ubiquinone oxidoreductase B17 subunit | Homo | <M><T><G><Y><T><P><D><E><K><L><R><L><Q><Q><L><R><E><L><R><R><R><W><L><K><D><Q><E><L><S><P><R><E><P><V><L><P><P><Q><K><M><G><P><M><E><K><F><W><N><K><F><L><E><N><K><S><P><W><R><K><M><V><H><G><V><Y><K><K><S><I><F><V><F><T><H><V><L><V><P><V><W><I><I><H><Y><Y><M><K><Y><H><V><S><E><K><P><Y><G><I><V><E><K><K><S><R><I><F><P><G><D><T><I><L><E><T><G><E><V><I><P><P><M><K><E><F><P><D><Q><H><H> | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.<BOP> | O95139 |
Q9Y508 | RN114_HUMAN | Zinc finger protein 313 | Homo | <M><A><A><Q><Q><R><D><C><G><G><A><A><Q><L><A><G><P><A><A><E><A><D><P><L><G><R><F><T><C><P><V><C><L><E><V><Y><E><K><P><V><Q><V><P><C><G><H><V><F><C><S><A><C><L><Q><E><C><L><K><P><K><K><P><V><C><G><V><C><R><S><A><L><A><P><G><V><R><A><V><E><L><E><R><Q><I><E><S><T><E><T><S><C><H><G><C><R><K><N><F><F><L><S><K><I><R><S><H><V><A><T><C><S><K><Y><Q><N><Y><I><M><E><G><V><K><A><T><I><K><D><A><S><L><Q><P><R><N><V><P><N><R><Y><T><F><P><C><P><Y><C><P><E><K><N><F><D><Q><E><G><L><V><E><H><C><K><L><F><H><S><T><D><T><K><S><V><V><C><P><I><C><A><S><M><P><W><G><D><P><N><Y><R><S><A><N><F><R><E><H><I><Q><R><R><H><R><F><S><Y><D><T><F><V><D><Y><D><V><D><E><E><D><M><M><N><Q><V><L><Q><R><S><I><I><D><Q> | E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates . In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity . Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 . May promote the ubiquitination of TRAF6 as well . Acts also as a negative regulator of T-cell activation . Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation . Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C . This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis.<BOP> | Q9Y508 |
A0A0A6YYG3 | TVB68_HUMAN | T cell receptor beta variable 6-8 | Homo | <M><S><L><G><L><L><C><C><A><A><F><S><L><L><W><A><G><P><V><N><A><G><V><T><Q><T><P><K><F><H><I><L><K><T><G><Q><S><M><T><L><Q><C><A><Q><D><M><N><H><G><Y><M><S><W><Y><R><Q><D><P><G><M><G><L><R><L><I><Y><Y><S><A><A><A><G><T><T><D><K><E><V><P><N><G><Y><N><V><S><R><L><N><T><E><D><F><P><L><R><L><V><S><A><A><P><S><Q><T><S><V><Y><L><C><A><S><S><Y> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0A6YYG3 |
Q9BY19 | M4A8_HUMAN | Membrane-spanning 4-domains subfamily A member 8B | Homo | <M><N><S><M><T><S><A><V><P><V><A><N><S><V><L><V><V><A><P><H><N><G><Y><P><V><T><P><G><I><M><S><H><V><P><L><Y><P><N><S><Q><P><Q><V><H><L><V><P><G><N><P><P><S><L><V><S><N><V><N><G><Q><P><V><Q><K><A><L><K><E><G><K><T><L><G><A><I><Q><I><I><I><G><L><A><H><I><G><L><G><S><I><M><A><T><V><L><V><G><E><Y><L><S><I><S><F><Y><G><G><F><P><F><W><G><G><L><W><F><I><I><S><G><S><L><S><V><A><A><E><N><Q><P><Y><S><Y><C><L><L><S><G><S><L><G><L><N><I><V><S><A><I><C><S><A><V><G><V><I><L><F><I><T><D><L><S><I><P><H><P><Y><A><Y><P><D><Y><Y><P><Y><A><W><G><V><N><P><G><M><A><I><S><G><V><L><L><V><F><C><L><L><E><F><G><I><A><C><A><S><S><H><F><G><C><Q><L><V><C><C><Q><S><S><N><V><S><V><I><Y><P><N><I><Y><A><A><N><P><V><I><T><P><E><P><V><T><S><P><P><S><Y><S><S><E><I><Q><A><N><K> | May be involved in signal transduction as a component of a multimeric receptor complex.<BOP> | Q9BY19 |
Q14894 | CRYM_HUMAN | NADP-regulated thyroid-hormone-binding protein | Homo | <M><S><R><V><P><A><F><L><S><A><A><E><V><E><E><H><L><R><S><S><S><L><L><I><P><P><L><E><T><A><L><A><N><F><S><S><G><P><E><G><G><V><M><Q><P><V><R><T><V><V><P><V><T><K><H><R><G><Y><L><G><V><M><P><A><Y><S><A><A><E><D><A><L><T><T><K><L><V><T><F><Y><E><D><R><G><I><T><S><V><V><P><S><H><Q><A><T><V><L><L><F><E><P><S><N><G><T><L><L><A><V><M><D><G><N><V><I><T><A><K><R><T><A><A><V><S><A><I><A><T><K><F><L><K><P><P><S><S><E><V><L><C><I><L><G><A><G><V><Q><A><Y><S><H><Y><E><I><F><T><E><Q><F><S><F><K><E><V><R><I><W><N><R><T><K><E><N><A><E><K><F><A><D><T><V><Q><G><E><V><R><V><C><S><S><V><Q><E><A><V><A><G><A><D><V><I><I><T><V><T><L><A><T><E><P><I><L><F><G><E><W><V><K><P><G><A><H><I><N><A><V><G><A><S><R><P><D><W><R><E><L><D><D><E><L><M><K><E><A><V><L><Y><V><D><S><Q><E><A><A><L><K><E><S><G><D><V><L><L><S><G><A><E><I><F><A><E><L><G><E><V><I><K><G><V><K><P><A><H><C><E><K><T><T><V><F><K><S><L><G><M><A><V><E><D><T><V><A><A><K><L><I><Y><D><S><W><S><S><G><K> | Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.<BOP> | Q14894 |
Q9Y3C8 | UFC1_HUMAN | Ubiquitin-fold modifier-conjugating enzyme 1 | Homo | <M><A><D><E><A><T><R><R><V><V><S><E><I><P><V><L><K><T><N><A><G><P><R><D><R><E><L><W><V><Q><R><L><K><E><E><Y><Q><S><L><I><R><Y><V><E><N><N><K><N><A><D><N><D><W><F><R><L><E><S><N><K><E><G><T><R><W><F><G><K><C><W><Y><I><H><D><L><L><K><Y><E><F><D><I><E><F><D><I><P><I><T><Y><P><T><T><A><P><E><I><A><V><P><E><L><D><G><K><T><A><K><M><Y><R><G><G><K><I><C><L><T><D><H><F><K><P><L><W><A><R><N><V><P><K><F><G><L><A><H><L><M><A><L><G><L><G><P><W><L><A><V><E><I><P><D><L><I><Q><K><G><V><I><Q><H><K><E><K><C><N><Q> | E1-like enzyme which specifically catalyzes the second step in ufmylation . Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage . Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress .<BOP> | Q9Y3C8 |
O94868 | FCSD2_HUMAN | SH3 multiple domains protein 3 | Homo | <M><Q><P><P><P><R><K><V><K><V><T><Q><E><L><K><N><I><Q><V><E><Q><M><T><K><L><Q><A><K><H><Q><A><E><C><D><L><L><E><D><M><R><T><F><S><Q><K><K><A><A><I><E><R><E><Y><A><Q><G><M><Q><K><L><A><S><Q><Y><L><K><R><D><W><P><G><V><K><A><D><D><R><N><D><Y><R><S><M><Y><P><V><W><K><S><F><L><E><G><T><M><Q><V><A><Q><S><R><M><N><I><C><E><N><Y><K><N><F><I><S><E><P><A><R><T><V><R><S><L><K><E><Q><Q><L><K><R><C><V><D><Q><L><T><K><I><Q><T><E><L><Q><E><T><V><K><D><L><A><K><G><K><K><K><Y><F><E><T><E><Q><M><A><H><A><V><R><E><K><A><D><I><E><A><K><S><K><L><S><L><F><Q><S><R><I><S><L><Q><K><A><S><V><K><L><K><A><R><R><S><E><C><N><S><K><A><T><H><A><R><N><D><Y><L><L><T><L><A><A><A><N><A><H><Q><D><R><Y><Y><Q><T><D><L><V><N><I><M><K><A><L><D><G><N><V><Y><D><H><L><K><D><Y><L><I><A><F><S><R><T><E><L><E><T><C><Q><A><V><Q><N><T><F><Q><F><L><L><E><N><S><S><K><V><V><R><D><Y><N><L><Q><L><F><L><Q><E><N><A><V><F><H><K><P><Q><P><F><Q><F><Q><P><C><D><S><D><T><S><R><Q><L><E><S><E><T><G><T><T><E><E><H><S><L><N><K><E><A><R><K><W><A><T><R><V><A><R><E><H><K><N><I><V><H><Q><Q><R><V><L><N><D><L><E><C><H><G><A><A><V><S><E><Q><S><R><A><E><L><E><Q><K><I><D><E><A><R><E><N><I><R><K><A><E><I><I><K><L><K><A><E><A><R><L><D><L><L><K><Q><I><G><V><S><V><D><T><W><L><K><S><A><M><N><Q><V><M><E><E><L><E><N><E><R><W><A><R><P><P><A><V><T><S><N><G><T><L><H><S><L><N><A><D><T><E><R><E><E><G><E><E><F><E><D><N><M><D><V><F><D><D><S><S><S><S><P><S><G><T><L><R><N><Y><P><L><T><C><K><V><V><Y><S><Y><K><A><S><Q><P><D><E><L><T><I><E><E><H><E><V><L><E><V><I><E><D><G><D><M><E><D><W><V><K><A><R><N><K><V><G><Q><V><G><Y><V><P><E><K><Y><L><Q><F><P><T><S><N><S><L><L><S><M><L><Q><S><L><A><A><L><D><S><R><S><H><T><S><S><N><S><T><E><A><E><L><V><S><G><S><L><N><G><D><A><S><V><C><F><V><K><A><L><Y><D><Y><E><G><Q><T><D><D><E><L><S><F><P><E><G><A><I><I><R><I><L><N><K><E><N><Q><D><D><D><G><F><W><E><G><E><F><N><G><R><I><G><V><F><P><S><V><L><V><E><E><L><S><A><S><E><N><G><D><T><P><W><M><R><E><I><Q><I><S><P><S><P><K><P><H><A><S><L><P><P><L><P><L><Y><D><Q><P><P><S><S><P><Y><P><S><P><D><K><R><S><S><L><Y><F><P><R><S><P><S><A><N><E><K><S><L><H><A><E><S><P><G><F><S><Q><A><S><R><H><T><P><E><T><S><Y><G><K><L><R><P><V><R><A><A><P><P><P><P><T><Q><N><H><R><R><P><A><E><K><I><E><D><V><E><I><T><L><V> | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor . Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling . Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits . Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate . When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes .<BOP> | O94868 |
Q13162 | PRDX4_HUMAN | Thioredoxin-dependent peroxiredoxin 4 | Homo | <M><E><A><L><P><L><L><A><A><T><T><P><D><H><G><R><H><R><R><L><L><L><L><P><L><L><L><F><L><L><P><A><G><A><V><Q><G><W><E><T><E><E><R><P><R><T><R><E><E><E><C><H><F><Y><A><G><G><Q><V><Y><P><G><E><A><S><R><V><S><V><A><D><H><S><L><H><L><S><K><A><K><I><S><K><P><A><P><Y><W><E><G><T><A><V><I><D><G><E><F><K><E><L><K><L><T><D><Y><R><G><K><Y><L><V><F><F><F><Y><P><L><D><F><T><F><V><C><P><T><E><I><I><A><F><G><D><R><L><E><E><F><R><S><I><N><T><E><V><V><A><C><S><V><D><S><Q><F><T><H><L><A><W><I><N><T><P><R><R><Q><G><G><L><G><P><I><R><I><P><L><L><S><D><L><T><H><Q><I><S><K><D><Y><G><V><Y><L><E><D><S><G><H><T><L><R><G><L><F><I><I><D><D><K><G><I><L><R><Q><I><T><L><N><D><L><P><V><G><R><S><V><D><E><T><L><R><L><V><Q><A><F><Q><Y><T><D><K><H><G><E><V><C><P><A><G><W><K><P><G><S><E><T><I><I><P><D><P><A><G><K><L><K><Y><F><D><K><L><N> | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.<BOP> | Q13162 |
Q8WZA1 | PMGT1_HUMAN | UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2 | Homo | <M><D><D><W><K><P><S><P><L><I><K><P><F><G><A><R><K><K><R><S><W><Y><L><T><W><K><Y><K><L><T><N><Q><R><A><L><R><R><F><C><Q><T><G><A><V><L><F><L><L><V><T><V><I><V><N><I><K><L><I><L><D><T><R><R><A><I><S><E><A><N><E><D><P><E><P><E><Q><D><Y><D><E><A><L><G><R><L><E><P><P><R><R><R><G><S><G><P><R><R><V><L><D><V><E><V><Y><S><S><R><S><K><V><Y><V><A><V><D><G><T><T><V><L><E><D><E><A><R><E><Q><G><R><G><I><H><V><I><V><L><N><Q><A><T><G><H><V><M><A><K><R><V><F><D><T><Y><S><P><H><E><D><E><A><M><V><L><F><L><N><M><V><A><P><G><R><V><L><I><C><T><V><K><D><E><G><S><F><H><L><K><D><T><A><K><A><L><L><R><S><L><G><S><Q><A><G><P><A><L><G><W><R><D><T><W><A><F><V><G><R><K><G><G><P><V><F><G><E><K><H><S><K><S><P><A><L><S><S><W><G><D><P><V><L><L><K><T><D><V><P><L><S><S><A><E><E><A><E><C><H><W><A><D><T><E><L><N><R><R><R><R><R><F><C><S><K><V><E><G><Y><G><S><V><C><S><C><K><D><P><T><P><I><E><F><S><P><D><P><L><P><D><N><K><V><L><N><V><P><V><A><V><I><A><G><N><R><P><N><Y><L><Y><R><M><L><R><S><L><L><S><A><Q><G><V><S><P><Q><M><I><T><V><F><I><D><G><Y><Y><E><E><P><M><D><V><V><A><L><F><G><L><R><G><I><Q><H><T><P><I><S><I><K><N><A><R><V><S><Q><H><Y><K><A><S><L><T><A><T><F><N><L><F><P><E><A><K><F><A><V><V><L><E><E><D><L><D><I><A><V><D><F><F><S><F><L><S><Q><S><I><H><L><L><E><E><D><D><S><L><Y><C><I><S><A><W><N><D><Q><G><Y><E><H><T><A><E><D><P><A><L><L><Y><R><V><E><T><M><P><G><L><G><W><V><L><R><R><S><L><Y><K><E><E><L><E><P><K><W><P><T><P><E><K><L><W><D><W><D><M><W><M><R><M><P><E><Q><R><R><G><R><E><C><I><I><P><D><V><S><R><S><Y><H><F><G><I><V><G><L><N><M><N><G><Y><F><H><E><A><Y><F><K><K><H><K><F><N><T><V><P><G><V><Q><L><R><N><V><D><S><L><K><K><E><A><Y><E><V><E><V><H><R><L><L><S><E><A><E><V><L><D><H><S><K><N><P><C><E><D><S><F><L><P><D><T><E><G><H><T><Y><V><A><F><I><R><M><E><K><D><D><D><F><T><T><W><T><Q><L><A><K><C><L><H><I><W><D><L><D><V><R><G><N><H><R><G><L><W><R><L><F><R><K><K><N><H><F><L><M><V><G><V><P><A><S><P><Y><S><V><K><K><P><P><S><V><T><P><I><F><L><E><P><P><P><K><E><E><G><A><P><G><A><P><E><Q><T> | Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins . Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties . Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity.<BOP> | Q8WZA1 |
P28067 | DMA_HUMAN | Really interesting new gene 6 protein | Homo | <M><G><H><E><Q><N><Q><G><A><A><L><L><Q><M><L><P><L><L><W><L><L><P><H><S><W><A><V><P><E><A><P><T><P><M><W><P><D><D><L><Q><N><H><T><F><L><H><T><V><Y><C><Q><D><G><S><P><S><V><G><L><S><E><A><Y><D><E><D><Q><L><F><F><F><D><F><S><Q><N><T><R><V><P><R><L><P><E><F><A><D><W><A><Q><E><Q><G><D><A><P><A><I><L><F><D><K><E><F><C><E><W><M><I><Q><Q><I><G><P><K><L><D><G><K><I><P><V><S><R><G><F><P><I><A><E><V><F><T><L><K><P><L><E><F><G><K><P><N><T><L><V><C><F><V><S><N><L><F><P><P><M><L><T><V><N><W><H><D><H><S><V><P><V><E><G><F><G><P><T><F><V><S><A><V><D><G><L><S><F><Q><A><F><S><Y><L><N><F><T><P><E><P><S><D><I><F><S><C><I><V><T><H><E><I><D><R><Y><T><A><I><A><Y><W><V><P><R><N><A><L><P><S><D><L><L><E><N><V><L><C><G><V><A><F><G><L><G><V><L><G><I><I><V><G><I><V><L><I><I><Y><F><R><K><P><C><S><G><D> | Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.<BOP> | P28067 |
Q9P2C4 | TM181_HUMAN | Transmembrane protein 181 | Homo | <M><G><A><A><P><S><P><T><Q><A><S><S><R><G><G><G><P><G><P><P><A><P><T><R><A><V><S><S><S><S><R><A><R><G><G><A><L><S><A><L><G><P><S><P><A><R><P><L><T><T><S><P><A><P><A><P><P><P><R><S><R><P><A><R><Q><Q><P><D><P><Q><C><W><E><K><R><G><G><A><G><G><D><T><K><G><G><A><A><G><P><G><P><G><R><L><R><G><M><D><A><E><Y><P><A><F><E><P><P><L><C><S><E><L><K><H><L><C><R><R><L><R><E><A><Y><R><E><L><K><E><D><L><T><P><F><K><D><D><R><Y><Y><R><L><A><P><M><R><L><Y><T><L><S><K><R><H><F><V><L><V><F><V><V><F><F><I><C><F><G><L><T><I><F><V><G><I><R><G><P><K><V><I><Q><T><S><A><A><N><F><S><L><N><N><S><K><K><L><K><P><I><Q><I><L><S><N><P><L><S><T><Y><N><Q><Q><L><W><L><T><C><V><V><E><L><D><Q><S><K><E><T><S><I><K><T><S><F><P><M><T><V><K><V><D><G><V><A><Q><D><G><T><T><M><Y><I><H><N><K><V><H><N><R><T><R><T><L><T><C><A><G><K><C><A><E><I><I><V><A><H><L><G><Y><L><N><Y><T><Q><Y><T><V><I><V><G><F><E><H><L><K><L><P><I><K><G><M><N><F><T><W><K><T><Y><N><P><A><F><S><R><L><E><I><W><F><R><F><F><F><V><V><L><T><F><I><V><T><C><L><F><A><H><S><L><R><K><F><S><M><R><D><W><G><I><E><Q><K><W><M><S><V><L><L><P><L><L><L><L><Y><N><D><P><F><F><P><L><S><F><L><V><N><S><W><L><P><G><M><L><D><D><L><F><Q><S><M><F><L><C><A><L><L><L><F><W><L><C><V><Y><H><G><I><R><V><Q><G><E><R><K><C><L><T><F><Y><L><P><K><F><F><I><V><G><L><L><W><L><A><S><V><T><L><G><I><W><Q><T><V><N><E><L><H><D><P><M><Y><Q><Y><R><V><D><T><G><N><F><Q><G><M><K><V><F><F><M><V><V><A><A><V><Y><I><L><Y><L><L><F><L><I><V><R><A><C><S><E><L><R><H><M><P><Y><V><D><L><R><L><K><F><L><T><A><L><T><F><V><V><L><V><I><S><I><A><I><L><Y><L><R><F><G><A><Q><V><L><Q><D><N><F><V><A><E><L><S><T><H><Y><Q><N><S><A><E><F><L><S><F><Y><G><L><L><N><F><Y><L><Y><T><L><A><F><V><Y><S><P><S><K><N><A><L><Y><E><S><Q><L><K><D><N><P><A><F><S><M><L><N><D><S><D><D><D><V><I><Y><G><S><D><Y><E><E><M><P><L><Q><N><G><Q><A><I><R><A><K><Y><K><E><E><S><D><S><D> | Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.<BOP> | Q9P2C4 |
P35754 | GLRX1_HUMAN | Thioltransferase-1 | Homo | <M><A><Q><E><F><V><N><C><K><I><Q><P><G><K><V><V><V><F><I><K><P><T><C><P><Y><C><R><R><A><Q><E><I><L><S><Q><L><P><I><K><Q><G><L><L><E><F><V><D><I><T><A><T><N><H><T><N><E><I><Q><D><Y><L><Q><Q><L><T><G><A><R><T><V><P><R><V><F><I><G><K><D><C><I><G><G><C><S><D><L><V><S><L><Q><Q><S><G><E><L><L><T><R><L><K><Q><I><G><A><L><Q> | Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.<BOP> | P35754 |
Q92851 | CASPA_HUMAN | Caspase-10 subunit p12 | Homo | <M><K><S><Q><G><Q><H><W><Y><S><S><S><D><K><N><C><K><V><S><F><R><E><K><L><L><I><I><D><S><N><L><G><V><Q><D><V><E><N><L><K><F><L><C><I><G><L><V><P><N><K><K><L><E><K><S><S><S><A><S><D><V><F><E><H><L><L><A><E><D><L><L><S><E><E><D><P><F><F><L><A><E><L><L><Y><I><I><R><Q><K><K><L><L><Q><H><L><N><C><T><K><E><E><V><E><R><L><L><P><T><R><Q><R><V><S><L><F><R><N><L><L><Y><E><L><S><E><G><I><D><S><E><N><L><K><D><M><I><F><L><L><K><D><S><L><P><K><T><E><M><T><S><L><S><F><L><A><F><L><E><K><Q><G><K><I><D><E><D><N><L><T><C><L><E><D><L><C><K><T><V><V><P><K><L><L><R><N><I><E><K><Y><K><R><E><K><A><I><Q><I><V><T><P><P><V><D><K><E><A><E><S><Y><Q><G><E><E><E><L><V><S><Q><T><D><V><K><T><F><L><E><A><L><P><Q><E><S><W><Q><N><K><H><A><G><S><N><G><N><R><A><T><N><G><A><P><S><L><V><S><R><G><M><Q><G><A><S><A><N><T><L><N><S><E><T><S><T><K><R><A><A><V><Y><R><M><N><R><N><H><R><G><L><C><V><I><V><N><N><H><S><F><T><S><L><K><D><R><Q><G><T><H><K><D><A><E><I><L><S><H><V><F><Q><W><L><G><F><T><V><H><I><H><N><N><V><T><K><V><E><M><E><M><V><L><Q><K><Q><K><C><N><P><A><H><A><D><G><D><C><F><V><F><C><I><L><T><H><G><R><F><G><A><V><Y><S><S><D><E><A><L><I><P><I><R><E><I><M><S><H><F><T><A><L><Q><C><P><R><L><A><E><K><P><K><L><F><F><I><Q><A><C><Q><G><E><E><I><Q><P><S><V><S><I><E><A><D><A><L><N><P><E><Q><A><P><T><S><L><Q><D><S><I><P><A><E><A><D><F><L><L><G><L><A><T><V><P><G><Y><V><S><F><R><H><V><E><E><G><S><W><Y><I><Q><S><L><C><N><H><L><K><K><L><V><P><R><M><L><K><F><L><E><K><T><M><E><I><R><G><R><K><R><T><V><W><G><A><K><Q><I><S><A><T><S><L><P><T><A><I><S><A><Q><T><P><R><P><P><M><R><R><W><S><S><V><S> | Isoform C is proteolytically inactive.<BOP> | Q92851 |
P47884 | OR1D4_HUMAN | Olfactory receptor 17-30 | Homo | <M><D><G><D><N><Q><S><E><N><S><Q><F><L><L><L><G><I><S><E><S><P><E><Q><Q><Q><I><L><F><W><M><F><L><S><M><Y><L><V><T><V><L><G><N><V><L><I><I><L><A><I><S><S><D><S><H><L><H><T><P><M><Y><F><F><L><A><N><L><S><F><T><D><L><F><F><V><T><N><T><I><P><K><M><L><V><N><F><Q><S><Q><N><K><A><I><S><Y><A><G><C><L><T><Q><L><Y><F><L><V><S><L><V><T><L><D><N><L><I><L><A><V><M><A><Y><D><R><Y><V><A><I><C><C><P><L><H><Y><V><T><A><M><S><P><G><L><C><V><L><L><L><S><L><C><W><G><L><S><V><L><Y><G><L><L><L><T><F><L><L><T><R><V><T><F><C><G><P><R><E><I><H><Y><L><F><C><D><M><Y><I><L><L><W><L><A><C><S><N><T><H><I><I><H><T><A><L><I><A><T><G><C><F><I><F><L><T><L><L><G><F><M><T><T><S><Y><V><R><I><V><R><T><I><L><Q><M><P><S><A><S><K><K><Y><K><T><F><S><T><C><A><S><H><L><G><V><V><S><L><F><Y><G><T><L><A><M><V><Y><L><Q><P><L><H><T><Y><S><M><K><D><S><V><A><T><V><M><Y><A><V><L><T><P><M><M><N><P><F><I><Y><S><L><R><N><K><D><M><H><G><A><P><G><R><V><L><W><R><P><F><Q><R><P> | Odorant receptor.<BOP> | P47884 |
P45452 | MMP13_HUMAN | Matrix metalloproteinase-13 | Homo | <M><H><P><G><V><L><A><A><F><L><F><L><S><W><T><H><C><R><A><L><P><L><P><S><G><G><D><E><D><D><L><S><E><E><D><L><Q><F><A><E><R><Y><L><R><S><Y><Y><H><P><T><N><L><A><G><I><L><K><E><N><A><A><S><S><M><T><E><R><L><R><E><M><Q><S><F><F><G><L><E><V><T><G><K><L><D><D><N><T><L><D><V><M><K><K><P><R><C><G><V><P><D><V><G><E><Y><N><V><F><P><R><T><L><K><W><S><K><M><N><L><T><Y><R><I><V><N><Y><T><P><D><M><T><H><S><E><V><E><K><A><F><K><K><A><F><K><V><W><S><D><V><T><P><L><N><F><T><R><L><H><D><G><I><A><D><I><M><I><S><F><G><I><K><E><H><G><D><F><Y><P><F><D><G><P><S><G><L><L><A><H><A><F><P><P><G><P><N><Y><G><G><D><A><H><F><D><D><D><E><T><W><T><S><S><S><K><G><Y><N><L><F><L><V><A><A><H><E><F><G><H><S><L><G><L><D><H><S><K><D><P><G><A><L><M><F><P><I><Y><T><Y><T><G><K><S><H><F><M><L><P><D><D><D><V><Q><G><I><Q><S><L><Y><G><P><G><D><E><D><P><N><P><K><H><P><K><T><P><D><K><C><D><P><S><L><S><L><D><A><I><T><S><L><R><G><E><T><M><I><F><K><D><R><F><F><W><R><L><H><P><Q><Q><V><D><A><E><L><F><L><T><K><S><F><W><P><E><L><P><N><R><I><D><A><A><Y><E><H><P><S><H><D><L><I><F><I><F><R><G><R><K><F><W><A><L><N><G><Y><D><I><L><E><G><Y><P><K><K><I><S><E><L><G><L><P><K><E><V><K><K><I><S><A><A><V><H><F><E><D><T><G><K><T><L><L><F><S><G><N><Q><V><W><R><Y><D><D><T><N><H><I><M><D><K><D><Y><P><R><L><I><E><E><D><F><P><G><I><G><D><K><V><D><A><V><Y><E><K><N><G><Y><I><Y><F><F><N><G><P><I><Q><F><E><Y><S><I><W><S><N><R><I><V><R><V><M><P><A><N><S><I><L><W><C> | Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.<BOP> | P45452 |
Q8N539 | FBCD1_HUMAN | Fibrinogen C domain-containing protein 1 | Homo | <M><V><N><D><R><W><K><T><M><G><G><A><A><Q><L><E><D><R><P><R><D><K><P><Q><R><P><S><C><G><Y><V><L><C><T><V><L><L><A><L><A><V><L><L><A><V><A><V><T><G><A><V><L><F><L><N><H><A><H><A><P><G><T><A><P><P><P><V><V><S><T><G><A><A><S><A><N><S><A><L><V><T><V><E><R><A><D><S><S><H><L><S><I><L><I><D><P><R><C><P><D><L><T><D><S><F><A><R><L><E><S><A><Q><A><S><V><L><Q><A><L><T><E><H><Q><A><Q><P><R><L><V><G><D><Q><E><Q><E><L><L><D><T><L><A><D><Q><L><P><R><L><L><A><R><A><S><E><L><Q><T><E><C><M><G><L><R><K><G><H><G><T><L><G><Q><G><L><S><A><L><Q><S><E><Q><G><R><L><I><Q><L><L><S><E><S><Q><G><H><M><A><H><L><V><N><S><V><S><D><I><L><D><A><L><Q><R><D><R><G><L><G><R><P><R><N><K><A><D><L><Q><R><A><P><A><R><G><T><R><P><R><G><C><A><T><G><S><R><P><R><D><C><L><D><V><L><L><S><G><Q><Q><D><D><G><V><Y><S><V><F><P><T><H><Y><P><A><G><F><Q><V><Y><C><D><M><R><T><D><G><G><G><W><T><V><F><Q><R><R><E><D><G><S><V><N><F><F><R><G><W><D><A><Y><R><D><G><F><G><R><L><T><G><E><H><W><L><G><L><K><R><I><H><A><L><T><T><Q><A><A><Y><E><L><H><V><D><L><E><D><F><E><N><G><T><A><Y><A><R><Y><G><S><F><G><V><G><L><F><S><V><D><P><E><E><D><G><Y><P><L><T><V><A><D><Y><S><G><T><A><G><D><S><L><L><K><H><S><G><M><R><F><T><T><K><D><R><D><S><D><H><S><E><N><N><C><A><A><F><Y><R><G><A><W><W><Y><R><N><C><H><T><S><N><L><N><G><Q><Y><L><R><G><A><H><A><S><Y><A><D><G><V><E><W><S><S><W><T><G><W><Q><Y><S><L><K><F><S><E><M><K><I><R><P><V><R><E><D><R> | Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.<BOP> | Q8N539 |
Q5VVQ6 | OTU1_HUMAN | OTU domain-containing protein 2 | Homo | <M><F><G><P><A><K><G><R><H><F><G><V><H><P><A><P><G><F><P><G><G><V><S><Q><Q><A><A><G><T><K><A><G><P><A><G><A><W><P><V><G><S><R><T><D><T><M><W><R><L><R><C><K><A><K><D><G><T><H><V><L><Q><G><L><S><S><R><T><R><V><R><E><L><Q><G><Q><I><A><A><I><T><G><I><A><P><G><G><Q><R><I><L><V><G><Y><P><P><E><C><L><D><L><S><N><G><D><T><I><L><E><D><L><P><I><Q><S><G><D><M><L><I><I><E><E><D><Q><T><R><P><R><S><S><P><A><F><T><K><R><G><A><S><S><Y><V><R><E><T><L><P><V><L><T><R><T><V><V><P><A><D><N><S><C><L><F><T><S><V><Y><Y><V><V><E><G><G><V><L><N><P><A><C><A><P><E><M><R><R><L><I><A><Q><I><V><A><S><D><P><D><F><Y><S><E><A><I><L><G><K><T><N><Q><E><Y><C><D><W><I><K><R><D><D><T><W><G><G><A><I><E><I><S><I><L><S><K><F><Y><Q><C><E><I><C><V><V><D><T><Q><T><V><R><I><D><R><F><G><E><D><A><G><Y><T><K><R><V><L><L><I><Y><D><G><I><H><Y><D><P><L><Q><R><N><F><P><D><P><D><T><P><P><L><T><I><F><S><S><N><D><D><I><V><L><V><Q><A><L><E><L><A><D><E><A><R><R><R><R><Q><F><T><D><V><N><R><F><T><L><R><C><M><V><C><Q><K><G><L><T><G><Q><A><E><A><R><E><H><A><K><E><T><G><H><T><N><F><G><E><V> | Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation .<BOP> | Q5VVQ6 |
Q9UM22 | EPDR1_HUMAN | Upregulated in colorectal cancer gene 1 protein | Homo | <M><P><G><R><A><P><L><R><T><V><P><G><A><L><G><A><W><L><L><G><G><L><W><A><W><T><L><C><G><L><C><S><L><G><A><V><G><A><P><R><P><C><Q><A><P><Q><Q><W><E><G><R><Q><V><M><Y><Q><Q><S><S><G><R><N><S><R><A><L><L><S><Y><D><G><L><N><Q><R><V><R><V><L><D><E><R><K><A><L><I><P><C><K><R><L><F><E><Y><I><L><L><Y><K><D><G><V><M><F><Q><I><D><Q><A><T><K><Q><C><S><K><M><T><L><T><Q><P><W><D><P><L><D><I><P><Q><N><S><T><F><E><D><Q><Y><S><I><G><G><P><Q><E><Q><I><T><V><Q><E><W><S><D><R><K><S><A><R><S><Y><E><T><W><I><G><I><Y><T><V><K><D><C><Y><P><V><Q><E><T><F><T><I><N><Y><S><V><I><L><S><T><R><F><F><D><I><Q><L><G><I><K><D><P><S><V><F><T><P><P><S><T><C><Q><M><A><Q><L><E><K><M><S><E><D><C><S><W> | Binds anionic lipids and gangliosides at acidic pH.<BOP> | Q9UM22 |
Q9H0G5 | NSRP1_HUMAN | Nuclear speckle-related protein 70 | Homo | <M><A><I><P><G><R><Q><Y><G><L><I><L><P><K><K><T><Q><Q><L><H><P><V><L><Q><K><P><S><V><F><G><N><D><S><D><D><D><D><E><T><S><V><S><E><S><L><Q><R><E><A><A><K><K><Q><A><M><K><Q><T><K><L><E><I><Q><K><A><L><A><E><D><A><T><V><Y><E><Y><D><S><I><Y><D><E><M><Q><K><K><K><E><E><N><N><P><K><L><L><L><G><K><D><R><K><P><K><Y><I><H><N><L><L><K><A><V><E><I><R><K><K><E><Q><E><K><R><M><E><K><K><I><Q><R><E><R><E><M><E><K><G><E><F><D><D><K><E><A><F><V><T><S><A><Y><K><K><K><L><Q><E><R><A><E><E><E><E><R><E><K><R><A><A><A><L><E><A><C><L><D><V><T><K><Q><K><D><L><S><G><F><Y><R><H><L><L><N><Q><A><V><G><E><E><E><V><P><K><C><S><F><R><E><A><R><S><G><I><K><E><E><K><S><R><G><F><S><N><E><V><S><S><K><N><R><I><P><Q><E><K><C><I><L><Q><T><D><V><K><V><E><E><N><P><D><A><D><S><D><F><D><A><K><S><S><A><D><D><E><I><E><E><T><R><V><N><C><R><R><E><K><V><I><E><T><P><E><N><D><F><K><H><H><R><S><Q><N><H><S><R><S><P><S><E><E><R><G><H><S><T><R><H><H><T><K><G><S><R><T><S><R><G><H><E><K><R><E><D><Q><H><Q><Q><K><Q><S><R><D><Q><E><N><H><Y><T><D><R><D><Y><R><K><E><R><D><S><H><R><H><R><E><A><S><H><R><D><S><H><W><K><R><H><E><Q><E><D><K><P><R><A><R><D><Q><R><E><R><S><D><R><V><W><K><R><E><K><D><R><E><K><Y><S><Q><R><E><Q><E><R><D><R><Q><Q><N><D><Q><N><R><P><S><E><K><G><E><K><E><E><K><S><K><A><K><E><E><H><M><K><V><R><K><E><R><Y><E><N><N><D><K><Y><R><D><R><E><K><R><E><V><G><V><Q><S><S><E><R><N><Q><D><R><K><E><S><S><P><N><S><R><A><K><D><K><F><L><D><Q><E><R><S><N><K><M><R><N><M><A><K><D><K><E><R><N><Q><E><K><P><S><N><S><E><S><S><L><G><A><K><H><R><L><T><E><E><G><Q><E><K><G><K><E><Q><E><R><P><P><E><A><V><S><K><F><A><K><R><N><N><E><E><T><V><M><S><A><R><D><R><Y><L><A><R><Q><M><A><R><V><N><A><K><T><Y><I><E><K><E><D><D> | RNA-binding protein that mediates pre-mRNA alternative splicing regulation.<BOP> | Q9H0G5 |
Q86WQ0 | NR2CA_HUMAN | TR4 orphan receptor-associated 16 kDa protein | Homo | <M><T><H><S><L><V><C><P><E><T><V><S><R><V><S><S><V><L><N><R><N><T><R><Q><F><G><K><K><H><L><F><D><Q><D><E><E><T><C><W><N><S><D><Q><G><P><S><Q><W><V><T><L><E><F><P><Q><L><I><R><V><S><Q><L><Q><I><Q><F><Q><G><G><F><S><S><R><R><G><C><L><E><G><S><Q><G><T><Q><A><L><H><K><I><V><D><F><Y><P><E><D><N><N><S><L><Q><T><F><P><I><P><A><A><E><V><D><R><L><K><V><T><F><E><D><A><T><D><F><F><G><R><V><V><I><Y><H><L><R><V><L><G><E><K><V> | May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.<BOP> | Q86WQ0 |
Q8NGE7 | OR9K2_HUMAN | Olfactory receptor OR12-2 | Homo | <M><L><G><S><K><P><R><V><H><L><Y><I><L><P><C><A><S><Q><Q><V><S><T><M><G><D><R><G><T><S><N><H><S><E><M><T><D><F><I><L><A><G><F><R><V><R><P><E><L><H><I><L><L><F><L><L><F><L><F><V><Y><A><M><I><L><L><G><N><V><G><M><M><T><I><I><M><T><D><P><R><L><N><T><P><M><Y><F><F><L><G><N><L><S><F><I><D><L><F><Y><S><S><V><I><E><P><K><A><M><I><N><F><W><S><E><N><K><S><I><S><F><A><G><C><V><A><Q><L><F><L><F><A><L><L><I><V><T><E><G><F><L><L><A><A><M><A><Y><D><R><F><I><A><I><C><N><P><L><L><Y><S><V><Q><M><S><T><R><L><C><T><Q><L><V><A><G><S><Y><F><C><G><C><I><S><S><V><I><Q><T><S><M><T><F><T><L><S><F><C><A><S><R><A><V><D><H><F><Y><C><D><S><R><P><L><Q><R><L><S><C><S><D><L><F><I><H><R><M><I><S><F><S><L><S><C><I><I><I><L><P><T><I><I><V><I><I><V><S><Y><M><Y><I><V><S><T><V><L><K><I><H><S><T><E><G><H><K><K><A><F><S><T><C><S><S><H><L><G><V><V><S><V><L><Y><G><A><V><F><F><M><Y><L><T><P><D><R><F><P><E><L><S><K><V><A><S><L><C><Y><S><L><V><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><Q><E><A><L><K><K><F><L><E><K><K><N><I><I><L> | Odorant receptor.<BOP> | Q8NGE7 |
Q8IUY3 | GRM2A_HUMAN | GRAM domain-containing protein 2A | Homo | <M><T><A><L><S><R><S><E><A><T><E><E><G><G><N><Q><Q><M><H><R><K><T><A><S><L><N><S><P><V><S><C><K><E><K><P><D><R><V><E><E><P><P><D><Y><S><L><H><W><P><E><G><L><K><G><E><E><I><K><K><C><G><R><E><G><I><T><L><N><K><Y><N><Q><Q><Y><H><K><L><F><K><D><V><P><L><E><E><V><V><L><K><V><C><S><C><A><L><Q><R><D><F><L><L><Q><G><R><L><Y><I><S><P><N><W><L><C><F><H><A><S><L><F><G><K><D><I><K><V><V><I><P><V><V><S><V><Q><M><I><K><K><H><K><M><A><R><L><L><P><N><G><L><A><I><T><T><N><T><S><Q><K><Y><I><F><V><S><L><L><S><R><D><S><V><Y><D><L><L><R><R><V><C><T><H><L><Q><P><S><S><K><K><S><L><S><V><R><E><F><S><G><E><P><E><S><L><E><V><L><I><P><E><M><K><W><R><K><V><C><P><S><S><R><S><L><S><L><P><D><N><I><P><C><I><P><P><S><S><V><D><S><T><D><S><F><F><P><S><R><K><P><P><M><S><E><K><S><R><A><Q><V><A><S><E><N><G><G><R><W><A><W><P><M><P><G><W><G><P><A><C><P><K><K><M><P><N><C><S><P><T><A><K><N><A><V><Y><E><E><D><E><L><E><E><E><P><R><S><T><G><E><L><R><L><W><D><Y><R><L><L><K><V><F><F><V><L><I><C><F><L><V><M><S><S><S><Y><L><A><F><R><I><S><R><L><E><Q><Q><L><C><S><L><S><W><D><D><P><V><P><G><H><R> | Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).<BOP> | Q8IUY3 |
Q9BUB5 | MKNK1_HUMAN | MAP kinase signal-integrating kinase 1 | Homo | <M><V><S><S><Q><K><L><E><K><P><I><E><M><G><S><S><E><P><L><P><I><A><D><G><D><R><R><R><K><K><K><R><R><G><R><A><T><D><S><L><P><G><K><F><E><D><M><Y><K><L><T><S><E><L><L><G><E><G><A><Y><A><K><V><Q><G><A><V><S><L><Q><N><G><K><E><Y><A><V><K><I><I><E><K><Q><A><G><H><S><R><S><R><V><F><R><E><V><E><T><L><Y><Q><C><Q><G><N><K><N><I><L><E><L><I><E><F><F><E><D><D><T><R><F><Y><L><V><F><E><K><L><Q><G><G><S><I><L><A><H><I><Q><K><Q><K><H><F><N><E><R><E><A><S><R><V><V><R><D><V><A><A><A><L><D><F><L><H><T><K><D><K><V><S><L><C><H><L><G><W><S><A><M><A><P><S><G><L><T><A><A><P><T><S><L><G><S><S><D><P><P><T><S><A><S><Q><V><A><G><T><T><G><I><A><H><R><D><L><K><P><E><N><I><L><C><E><S><P><E><K><V><S><P><V><K><I><C><D><F><D><L><G><S><G><M><K><L><N><N><S><C><T><P><I><T><T><P><E><L><T><T><P><C><G><S><A><E><Y><M><A><P><E><V><V><E><V><F><T><D><Q><A><T><F><Y><D><K><R><C><D><L><W><S><L><G><V><V><L><Y><I><M><L><S><G><Y><P><P><F><V><G><H><C><G><A><D><C><G><W><D><R><G><E><V><C><R><V><C><Q><N><K><L><F><E><S><I><Q><E><G><K><Y><E><F><P><D><K><D><W><A><H><I><S><S><E><A><K><D><L><I><S><K><L><L><V><R><D><A><K><Q><R><L><S><A><A><Q><V><L><Q><H><P><W><V><Q><G><Q><A><P><E><K><G><L><P><T><P><Q><V><L><Q><R><N><S><S><T><M><D><L><T><L><F><A><A><E><A><I><A><L><N><R><Q><L><S><Q><H><E><E><N><E><L><A><E><E><P><E><A><L><A><D><G><L><C><S><M><K><L><S><P><P><C><K><S><R><L><A><R><R><R><A><L><A><Q><A><G><R><G><E><D><R><S><P><P><T><A><L> | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.<BOP> | Q9BUB5 |
Q1HG44 | DOXA2_HUMAN | Dual oxidase activator 2 | Homo | <M><T><L><W><N><G><V><L><P><F><Y><P><Q><P><R><H><A><A><G><F><S><V><P><L><L><I><V><I><L><V><F><L><A><L><A><A><S><F><L><L><I><L><P><G><I><R><G><H><S><R><W><F><W><L><V><R><V><L><L><S><L><F><I><G><A><E><I><V><A><V><H><F><S><A><E><W><F><V><G><T><V><N><T><N><T><S><Y><K><A><F><S><A><A><R><V><T><A><R><V><R><L><L><V><G><L><E><G><I><N><I><T><L><T><G><T><P><V><H><Q><L><N><E><T><I><D><Y><N><E><Q><F><T><W><R><L><K><E><N><Y><A><A><E><Y><A><N><A><L><E><K><G><L><P><D><P><V><L><Y><L><A><E><K><F><T><P><S><S><P><C><G><L><Y><H><Q><Y><H><L><A><G><H><Y><A><S><A><T><L><W><V><A><F><C><F><W><L><L><S><N><V><L><L><S><T><P><A><P><L><Y><G><G><L><A><L><L><T><T><G><A><F><A><L><F><G><V><F><A><L><A><S><I><S><S><V><P><L><C><P><L><R><L><G><S><S><A><L><T><T><Q><Y><G><A><A><F><W><V><T><L><A><T><G><V><L><C><L><F><L><G><G><A><V><V><S><L><Q><Y><V><R><P><S><A><L><R><T><L><L><D><Q><S><A><K><D><C><S><Q><E><R><G><G><S><P><L><I><L><G><D><P><L><H><K><Q><A><A><L><P><D><L><K><C><I><T><T><N><L> | Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis.<BOP> | Q1HG44 |
Q9H4E5 | RHOJ_HUMAN | Tc10-like GTP-binding protein | Homo | <M><N><C><K><E><G><T><D><S><S><C><G><C><R><G><N><D><E><K><K><M><L><K><C><V><V><V><G><D><G><A><V><G><K><T><C><L><L><M><S><Y><A><N><D><A><F><P><E><E><Y><V><P><T><V><F><D><H><Y><A><V><T><V><T><V><G><G><K><Q><H><L><L><G><L><Y><D><T><A><G><Q><E><D><Y><N><Q><L><R><P><L><S><Y><P><N><T><D><V><F><L><I><C><F><S><V><V><N><P><A><S><Y><H><N><V><Q><E><E><W><V><P><E><L><K><D><C><M><P><H><V><P><Y><V><L><I><G><T><Q><I><D><L><R><D><D><P><K><T><L><A><R><L><L><Y><M><K><E><K><P><L><T><Y><E><H><G><V><K><L><A><K><A><I><G><A><Q><C><Y><L><E><C><S><A><L><T><Q><K><G><L><K><A><V><F><D><E><A><I><L><T><I><F><H><P><K><K><K><K><K><R><C><S><E><G><H><S><C><C><S><I><I> | Plasma membrane-associated small GTPase specifically involved in angiogenesis . Required for endothelial cell migration during vascular development via its interaction with GLUL . Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration .<BOP> | Q9H4E5 |
Q86VK4 | ZN410_HUMAN | Another partner for ARF 1 | Homo | <M><L><S><D><E><L><E><S><K><P><E><L><L><V><Q><F><V><Q><N><T><S><I><P><L><G><Q><G><L><V><E><S><E><A><K><D><I><T><C><L><S><L><L><P><V><T><E><A><S><E><C><S><R><L><M><L><P><D><D><T><T><N><H><S><N><S><S><K><E><V><P><S><S><A><V><L><R><S><L><R><V><N><V><G><P><D><G><E><E><T><R><A><Q><T><V><Q><K><S><P><E><F><L><S><T><S><E><S><S><S><L><L><Q><D><L><Q><P><S><D><S><T><S><F><I><L><L><N><L><T><R><A><G><L><G><S><S><A><E><H><L><V><F><V><Q><D><E><A><E><D><S><G><N><D><F><L><S><S><E><S><T><D><S><S><I><P><W><F><L><R><V><Q><E><L><A><H><D><S><L><I><A><A><T><R><A><Q><L><A><K><N><A><K><T><S><S><N><G><E><N><V><H><L><G><S><G><D><G><Q><S><K><D><S><G><P><L><P><Q><V><E><K><K><L><K><C><T><V><E><G><C><D><R><T><F><V><W><P><A><H><F><K><Y><H><L><K><T><H><R><N><D><R><S><F><I><C><P><A><E><G><C><G><K><S><F><Y><V><L><Q><R><L><K><V><H><M><R><T><H><N><G><E><K><P><F><M><C><H><E><S><G><C><G><K><Q><F><T><T><A><G><N><L><K><N><H><R><R><I><H><T><G><E><K><P><F><L><C><E><A><Q><G><C><G><R><S><F><A><E><Y><S><S><L><R><K><H><L><V><V><H><S><G><E><K><P><H><Q><C><Q><V><C><G><K><T><F><S><Q><S><G><S><R><N><V><H><M><R><K><H><H><L><Q><L><G><A><A><G><S><Q><E><Q><E><Q><T><A><E><P><L><M><G><S><S><L><L><E><E><A><S><V><P><S><K><N><L><V><S><M><N><S><Q><P><S><L><G><G><E><S><L><N><L><P><N><T><N><S><I><L><G><V><D><D><E><V><L><A><E><G><S><P><R><S><L><S><S><V><P><D><V><T><H><H><L><V><T><M><Q><S><G><R><Q><S><Y><E><V><S><V><L><T><A><V><N><P><Q><E><L><L><N><Q><G><D><L><T><E><R><R><T> | Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells . Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells . May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence . May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose . However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 .<BOP> | Q86VK4 |
Q495M9 | USH1G_HUMAN | Usher syndrome type-1G protein | Homo | <M><N><D><Q><Y><H><R><A><A><R><D><G><Y><L><E><L><L><K><E><A><T><R><K><E><L><N><A><P><D><E><D><G><M><T><P><T><L><W><A><A><Y><H><G><N><L><E><S><L><R><L><I><V><S><R><G><G><D><P><D><K><C><D><I><W><G><N><T><P><L><H><L><A><A><S><N><G><H><L><H><C><L><S><F><L><V><S><F><G><A><N><I><W><C><L><D><N><D><Y><H><T><P><L><D><M><A><A><M><K><G><H><M><E><C><V><R><Y><L><D><S><I><A><A><K><Q><S><S><L><N><P><K><L><V><G><K><L><K><D><K><A><F><R><E><A><E><R><R><I><R><E><C><A><K><L><Q><R><R><H><H><E><R><M><E><R><R><Y><R><R><E><L><A><E><R><S><D><T><L><S><F><S><S><L><T><S><S><T><L><S><R><R><L><Q><H><L><A><L><G><S><H><L><P><Y><S><Q><A><T><L><H><G><T><A><R><G><K><T><K><M><Q><K><K><L><E><R><R><K><Q><G><G><E><G><T><F><K><V><S><E><D><G><R><K><S><A><R><S><L><S><G><L><Q><L><G><S><D><V><M><F><V><R><Q><G><T><Y><A><N><P><K><E><W><G><R><A><P><L><R><D><M><F><L><S><D><E><D><S><V><S><R><A><T><L><A><A><E><P><A><H><S><E><V><S><T><D><S><G><H><D><S><L><F><T><R><P><G><L><G><T><M><V><F><R><R><N><Y><L><S><S><G><L><H><G><L><G><R><E><D><G><G><L><D><G><V><G><A><P><R><G><R><L><Q><S><S><P><S><L><D><D><D><S><L><G><S><A><N><S><L><Q><D><R><S><C><G><E><E><L><P><W><D><E><L><D><L><G><L><D><E><D><L><E><P><E><T><S><P><L><E><T><F><L><A><S><L><H><M><E><D><F><A><A><L><L><R><Q><E><K><I><D><L><E><A><L><M><L><C><S><D><L><D><L><R><S><I><S><V><P><L><G><P><R><K><K><I><L><G><A><V><R><R><R><R><Q><A><M><E><R><P><P><A><L><E><D><T><E><L> | Plays a role in pre-mRNA splicing by regulating the release and transfer of U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complexes from their assembly site in Cajal bodies to nuclear speckles, thereby contributing to the assembly of the pre-catalytic spliceosome on target pre-mRNAs . May also participate in recycling of snRNPs back to Cajal bodies during splicing . Plays a role in regulating MAGI2-mediated endocytosis . Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. Required for normal hearing.<BOP> | Q495M9 |
Q9HC97 | GPR35_HUMAN | Kynurenic acid receptor | Homo | <M><N><G><T><Y><N><T><C><G><S><S><D><L><T><W><P><P><A><I><K><L><G><F><Y><A><Y><L><G><V><L><L><V><L><G><L><L><L><N><S><L><A><L><W><V><F><C><C><R><M><Q><Q><W><T><E><T><R><I><Y><M><T><N><L><A><V><A><D><L><C><L><L><C><T><L><P><F><V><L><H><S><L><R><D><T><S><D><T><P><L><C><Q><L><S><Q><G><I><Y><L><T><N><R><Y><M><S><I><S><L><V><T><A><I><A><V><D><R><Y><V><A><V><R><H><P><L><R><A><R><G><L><R><S><P><R><Q><A><A><A><V><C><A><V><L><W><V><L><V><I><G><S><L><V><A><R><W><L><L><G><I><Q><E><G><G><F><C><F><R><S><T><R><H><N><F><N><S><M><A><F><P><L><L><G><F><Y><L><P><L><A><V><V><V><F><C><S><L><K><V><V><T><A><L><A><Q><R><P><P><T><D><V><G><Q><A><E><A><T><R><K><A><A><R><M><V><W><A><N><L><L><V><F><V><V><C><F><L><P><L><H><V><G><L><T><V><R><L><A><V><G><W><N><A><C><A><L><L><E><T><I><R><R><A><L><Y><I><T><S><K><L><S><D><A><N><C><C><L><D><A><I><C><Y><Y><Y><M><A><K><E><F><Q><E><A><S><A><L><A><V><A><P><S><A><K><A><H><K><S><Q><D><S><L><C><V><T><L><A> | Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.<BOP> | Q9HC97 |
Q13418 | ILK_HUMAN | p59ILK | Homo | <M><D><D><I><F><T><Q><C><R><E><G><N><A><V><A><V><R><L><W><L><D><N><T><E><N><D><L><N><Q><G><D><D><H><G><F><S><P><L><H><W><A><C><R><E><G><R><S><A><V><V><E><M><L><I><M><R><G><A><R><I><N><V><M><N><R><G><D><D><T><P><L><H><L><A><A><S><H><G><H><R><D><I><V><Q><K><L><L><Q><Y><K><A><D><I><N><A><V><N><E><H><G><N><V><P><L><H><Y><A><C><F><W><G><Q><D><Q><V><A><E><D><L><V><A><N><G><A><L><V><S><I><C><N><K><Y><G><E><M><P><V><D><K><A><K><A><P><L><R><E><L><L><R><E><R><A><E><K><M><G><Q><N><L><N><R><I><P><Y><K><D><T><F><W><K><G><T><T><R><T><R><P><R><N><G><T><L><N><K><H><S><G><I><D><F><K><Q><L><N><F><L><T><K><L><N><E><N><H><S><G><E><L><W><K><G><R><W><Q><G><N><D><I><V><V><K><V><L><K><V><R><D><W><S><T><R><K><S><R><D><F><N><E><E><C><P><R><L><R><I><F><S><H><P><N><V><L><P><V><L><G><A><C><Q><S><P><P><A><P><H><P><T><L><I><T><H><W><M><P><Y><G><S><L><Y><N><V><L><H><E><G><T><N><F><V><V><D><Q><S><Q><A><V><K><F><A><L><D><M><A><R><G><M><A><F><L><H><T><L><E><P><L><I><P><R><H><A><L><N><S><R><S><V><M><I><D><E><D><M><T><A><R><I><S><M><A><D><V><K><F><S><F><Q><C><P><G><R><M><Y><A><P><A><W><V><A><P><E><A><L><Q><K><K><P><E><D><T><N><R><R><S><A><D><M><W><S><F><A><V><L><L><W><E><L><V><T><R><E><V><P><F><A><D><L><S><N><M><E><I><G><M><K><V><A><L><E><G><L><R><P><T><I><P><P><G><I><S><P><H><V><C><K><L><M><K><I><C><M><N><E><D><P><A><K><R><P><K><F><D><M><I><V><P><I><L><E><K><M><Q><D><K> | Receptor-proximal protein kinase regulating integrin-mediated signal transduction . May act as a mediator of inside-out integrin signaling . Focal adhesion protein part of the complex ILK-PINCH . This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway . Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells . Regulates cell motility by forming a complex with PARVB . Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B .<BOP> | Q13418 |
Q8NGI6 | OR4DA_HUMAN | Olfactory receptor OR11-251 | Homo | <M><E><M><E><N><C><T><R><V><K><E><F><I><F><L><G><L><T><Q><N><R><E><V><S><L><V><L><F><L><F><L><L><L><V><Y><V><T><T><L><L><G><N><L><L><I><M><V><T><V><T><C><E><S><R><L><H><T><P><M><Y><F><L><L><H><N><L><S><I><A><D><I><C><F><S><S><I><T><V><P><K><V><L><V><D><L><L><S><E><R><K><T><I><S><F><N><H><C><F><T><Q><M><F><L><F><H><L><I><G><G><V><D><V><F><S><L><S><V><M><A><L><D><R><Y><V><A><I><S><K><P><L><H><Y><A><T><I><M><S><R><D><H><C><I><G><L><T><V><A><A><W><L><G><G><F><V><H><S><I><V><Q><I><S><L><L><L><P><L><P><F><C><G><P><N><V><L><D><T><F><Y><C><D><V><H><R><V><L><K><L><A><H><T><D><I><F><I><L><E><L><L><M><I><S><N><N><G><L><L><T><T><L><W><F><F><L><L><L><V><S><Y><I><V><I><L><S><L><P><K><S><Q><A><G><E><G><R><R><K><A><I><S><T><C><T><S><H><I><T><V><V><T><L><H><F><V><P><C><I><Y><V><Y><A><R><P><F><T><A><L><P><M><D><K><A><I><S><V><T><F><T><V><I><S><P><L><L><N><P><L><I><Y><T><L><R><N><H><E><M><K><S><A><M><R><R><L><K><R><R><L><V><P><S><D><R><K> | Odorant receptor.<BOP> | Q8NGI6 |
Q6ZNH5 | ZN497_HUMAN | Zinc finger protein 497 | Homo | <M><E><S><P><R><G><W><T><L><Q><V><A><P><E><E><G><Q><V><L><C><N><V><K><T><A><T><R><G><L><S><E><G><A><V><S><G><G><W><G><A><W><E><N><S><T><E><V><P><R><E><A><G><D><G><Q><R><Q><Q><A><T><L><G><A><A><D><E><Q><G><G><P><G><R><E><L><G><P><A><D><G><G><R><D><G><A><G><P><R><S><E><P><A><D><R><A><L><R><P><S><P><L><P><E><E><P><G><C><R><C><G><E><C><G><K><A><F><S><Q><G><S><Y><L><L><Q><H><R><R><V><H><T><G><E><K><P><Y><T><C><P><E><C><G><K><A><F><A><W><S><S><N><L><S><Q><H><Q><R><I><H><S><G><E><K><P><Y><A><C><R><E><C><G><K><A><F><R><A><H><S><Q><L><I><H><H><Q><E><T><H><S><G><L><K><P><F><R><C><P><D><C><G><K><S><F><G><R><S><T><T><L><V><Q><H><R><R><T><H><T><G><E><K><P><Y><E><C><P><E><C><G><K><A><F><S><W><N><S><N><F><L><E><H><R><R><V><H><T><G><A><R><P><H><A><C><R><D><C><G><K><A><F><S><Q><S><S><N><L><A><E><H><L><K><I><H><A><G><A><R><P><H><A><C><P><D><C><G><K><A><F><V><R><V><A><G><L><R><Q><H><R><R><T><H><S><S><E><K><P><F><P><C><A><E><C><G><K><A><F><R><E><S><S><Q><L><L><Q><H><Q><R><T><H><T><G><E><R><P><F><E><C><A><E><C><G><Q><A><F><V><M><G><S><Y><L><A><E><H><R><R><V><H><T><G><E><K><P><H><A><C><A><Q><C><G><K><A><F><S><Q><R><S><N><L><L><S><H><R><R><T><H><S><G><A><K><P><F><A><C><A><D><C><G><K><A><F><R><G><S><S><G><L><A><H><H><R><L><S><H><T><G><E><R><P><F><A><C><A><E><C><G><K><A><F><R><G><S><S><E><L><R><Q><H><Q><R><L><H><S><G><E><R><P><F><V><C><A><H><C><S><K><A><F><V><R><K><S><E><L><L><S><H><R><R><T><H><T><G><E><R><P><Y><A><C><G><E><C><G><K><P><F><S><H><R><C><N><L><N><E><H><Q><K><R><H><G><G><R><A><A><P> | May be involved in transcriptional regulation.<BOP> | Q6ZNH5 |
Q13158 | FADD_HUMAN | Mediator of receptor induced toxicity | Homo | <M><D><P><F><L><V><L><L><H><S><V><S><S><S><L><S><S><S><E><L><T><E><L><K><F><L><C><L><G><R><V><G><K><R><K><L><E><R><V><Q><S><G><L><D><L><F><S><M><L><L><E><Q><N><D><L><E><P><G><H><T><E><L><L><R><E><L><L><A><S><L><R><R><H><D><L><L><R><R><V><D><D><F><E><A><G><A><A><A><G><A><A><P><G><E><E><D><L><C><A><A><F><N><V><I><C><D><N><V><G><K><D><W><R><R><L><A><R><Q><L><K><V><S><D><T><K><I><D><S><I><E><D><R><Y><P><R><N><L><T><E><R><V><R><E><S><L><R><I><W><K><N><T><E><K><E><N><A><T><V><A><H><L><V><G><A><L><R><S><C><Q><M><N><L><V><A><D><L><V><Q><E><V><Q><Q><A><R><D><L><Q><N><R><S><G><A><M><S><P><M><S><W><N><S><D><A><S><T><S><E><A><S> | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors . The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation . Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis . Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling .<BOP> | Q13158 |
Q9BWD1 | THIC_HUMAN | Cytosolic acetoacetyl-CoA thiolase | Homo | <M><N><A><G><S><D><P><V><V><I><V><S><A><A><R><T><I><I><G><S><F><N><G><A><L><A><A><V><P><V><Q><D><L><G><S><T><V><I><K><E><V><L><K><R><A><T><V><A><P><E><D><V><S><E><V><I><F><G><H><V><L><A><A><G><C><G><Q><N><P><V><R><Q><A><S><V><G><A><G><I><P><Y><S><V><P><A><W><S><C><Q><M><I><C><G><S><G><L><K><A><V><C><L><A><V><Q><S><I><G><I><G><D><S><S><I><V><V><A><G><G><M><E><N><M><S><K><A><P><H><L><A><Y><L><R><T><G><V><K><I><G><E><M><P><L><T><D><S><I><L><C><D><G><L><T><D><A><F><H><N><C><H><M><G><I><T><A><E><N><V><A><K><K><W><Q><V><S><R><E><D><Q><D><K><V><A><V><L><S><Q><N><R><T><E><N><A><Q><K><A><G><H><F><D><K><E><I><V><P><V><L><V><S><T><R><K><G><L><I><E><V><K><T><D><E><F><P><R><H><G><S><N><I><E><A><M><S><K><L><K><P><Y><F><L><T><D><G><T><G><T><V><T><P><A><N><A><S><G><I><N><D><G><A><A><A><V><V><L><M><K><K><S><E><A><D><K><R><G><L><T><P><L><A><R><I><V><S><W><S><Q><V><G><V><E><P><S><I><M><G><I><G><P><I><P><A><I><K><Q><A><V><T><K><A><G><W><S><L><E><D><V><D><I><F><E><I><N><E><A><F><A><A><V><S><A><A><I><V><K><E><L><G><L><N><P><E><K><V><N><I><E><G><G><A><I><A><L><G><H><P><L><G><A><S><G><C><R><I><L><V><T><L><L><H><T><L><E><R><M><G><R><S><R><G><V><A><A><L><C><I><G><G><G><M><G><I><A><M><C><V><Q><R><E> | Involved in the biosynthetic pathway of cholesterol.<BOP> | Q9BWD1 |
Q00978 | IRF9_HUMAN | Transcriptional regulator ISGF3 subunit gamma | Homo | <M><A><S><G><R><A><R><C><T><R><K><L><R><N><W><V><V><E><Q><V><E><S><G><Q><F><P><G><V><C><W><D><D><T><A><K><T><M><F><R><I><P><W><K><H><A><G><K><Q><D><F><R><E><D><Q><D><A><A><F><F><K><A><W><A><I><F><K><G><K><Y><K><E><G><D><T><G><G><P><A><V><W><K><T><R><L><R><C><A><L><N><K><S><S><E><F><K><E><V><P><E><R><G><R><M><D><V><A><E><P><Y><K><V><Y><Q><L><L><P><P><G><I><V><S><G><Q><P><G><T><Q><K><V><P><S><K><R><Q><H><S><S><V><S><S><E><R><K><E><E><E><D><A><M><Q><N><C><T><L><S><P><S><V><L><Q><D><S><L><N><N><E><E><E><G><A><S><G><G><A><V><H><S><D><I><G><S><S><S><S><S><S><S><P><E><P><Q><E><V><T><D><T><T><E><A><P><F><Q><G><D><Q><R><S><L><E><F><L><L><P><P><E><P><D><Y><S><L><L><L><T><F><I><Y><N><G><R><V><V><G><E><A><Q><V><Q><S><L><D><C><R><L><V><A><E><P><S><G><S><E><S><S><M><E><Q><V><L><F><P><K><P><G><P><L><E><P><T><Q><R><L><L><S><Q><L><E><R><G><I><L><V><A><S><N><P><R><G><L><F><V><Q><R><L><C><P><I><P><I><S><W><N><A><P><Q><A><P><P><G><P><G><P><H><L><L><P><S><N><E><C><V><E><L><F><R><T><A><Y><F><C><R><D><L><V><R><Y><F><Q><G><L><G><P><P><P><K><F><Q><V><T><L><N><F><W><E><E><S><H><G><S><S><H><T><P><Q><N><L><I><T><V><K><M><E><Q><A><F><A><R><Y><L><L><E><Q><T><P><E><Q><Q><A><A><I><L><S><L><V> | Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.<BOP> | Q00978 |
Q7L3S4 | ZN771_HUMAN | Mesenchymal stem cell protein DSC43 | Homo | <M><P><G><E><Q><Q><A><E><E><E><E><E><E><E><M><Q><E><E><M><V><L><L><V><K><G><E><E><D><E><G><E><E><K><Y><E><V><V><K><L><K><I><P><M><D><N><K><E><V><P><G><E><A><P><A><P><S><A><D><P><A><R><P><H><A><C><P><D><C><G><R><A><F><A><R><R><S><T><L><A><K><H><A><R><T><H><T><G><E><R><P><F><G><C><T><E><C><G><R><R><F><S><Q><K><S><A><L><T><K><H><G><R><T><H><T><G><E><R><P><Y><E><C><P><E><C><D><K><R><F><S><A><A><S><N><L><R><Q><H><R><R><R><H><T><G><E><K><P><Y><A><C><A><H><C><G><R><R><F><A><Q><S><S><N><Y><A><Q><H><L><R><V><H><T><G><E><K><P><Y><A><C><P><D><C><G><R><A><F><G><G><S><S><C><L><A><R><H><R><R><T><H><T><G><E><R><P><Y><A><C><A><D><C><G><T><R><F><A><Q><S><S><A><L><A><K><H><R><R><V><H><T><G><E><K><P><H><R><C><A><V><C><G><R><R><F><G><H><R><S><N><L><A><E><H><A><R><T><H><T><G><E><R><P><Y><P><C><A><E><C><G><R><R><F><R><L><S><S><H><F><I><R><H><R><R><A><H><M><R><R><R><L><Y><I><C><A><G><C><G><R><D><F><K><L><P><P><G><A><T><A><A><T><A><T><E><R><C><P><E><C><E><G><S> | May be involved in transcriptional regulation.<BOP> | Q7L3S4 |
P43632 | KI2S4_HUMAN | P58 natural killer cell receptor clones CL-39/CL-17 | Homo | <M><S><L><M><V><I><I><M><A><C><V><G><F><F><L><L><Q><G><A><W><P><Q><E><G><V><H><R><K><P><S><F><L><A><L><P><G><H><L><V><K><S><E><E><T><V><I><L><Q><C><W><S><D><V><M><F><E><H><F><L><L><H><R><E><G><K><F><N><N><T><L><H><L><I><G><E><H><H><D><G><V><S><K><A><N><F><S><I><G><P><M><M><P><V><L><A><G><T><Y><R><C><Y><G><S><V><P><H><S><P><Y><Q><L><S><A><P><S><D><P><L><D><M><V><I><I><G><L><Y><E><K><P><S><L><S><A><Q><P><G><P><T><V><Q><A><G><E><N><V><T><L><S><C><S><S><R><S><S><Y><D><M><Y><H><L><S><R><E><G><E><A><H><E><R><R><L><P><A><V><R><S><I><N><G><T><F><Q><A><D><F><P><L><G><P><A><T><H><G><G><T><Y><R><C><F><G><S><F><R><D><A><P><Y><E><W><S><N><S><S><D><P><L><L><V><S><V><T><G><N><P><S><N><S><W><P><S><P><T><E><P><S><S><K><T><G><N><P><R><H><L><H><V><L><I><G><T><S><V><V><K><I><P><F><T><I><L><L><F><F><L><L><H><R><W><C><S><D><K><K><N><A><A><V><M><D><Q><E><P><A><G><N><R><T><V><N><S><E><D><S><D><E><Q><D><H><Q><E><V><S><Y><A> | Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.<BOP> | P43632 |
Q9Y5P6 | GMPPB_HUMAN | GTP-mannose-1-phosphate guanylyltransferase beta | Homo | <M><K><A><L><I><L><V><G><G><Y><G><T><R><L><R><P><L><T><L><S><T><P><K><P><L><V><D><F><C><N><K><P><I><L><L><H><Q><V><E><A><L><A><A><A><G><V><D><H><V><I><L><A><V><S><Y><M><S><Q><V><L><E><K><E><M><K><A><Q><E><Q><R><L><G><I><R><I><S><M><S><H><E><E><E><P><L><G><T><A><G><P><L><A><L><A><R><D><L><L><S><E><T><A><D><P><F><F><V><L><N><S><D><V><I><C><D><F><P><F><Q><A><M><V><Q><F><H><R><H><H><G><Q><E><G><S><I><L><V><T><K><V><E><E><P><S><K><Y><G><V><V><V><C><E><A><D><T><G><R><I><H><R><F><V><E><K><P><Q><V><F><V><S><N><K><I><N><A><G><M><Y><I><L><S><P><A><V><L><Q><R><I><Q><L><Q><P><T><S><I><E><K><E><V><F><P><I><M><A><K><E><G><Q><L><Y><A><M><E><L><Q><G><F><W><M><D><I><G><Q><P><K><D><F><L><T><G><M><C><L><F><L><Q><S><L><R><Q><K><Q><P><E><R><L><C><S><G><P><G><I><V><G><N><V><L><V><D><P><S><A><R><I><G><Q><N><C><S><I><G><P><N><V><S><L><G><P><G><V><V><V><E><D><G><V><C><I><R><R><C><T><V><L><R><D><A><R><I><R><S><H><S><W><L><E><S><C><I><V><G><W><R><C><R><V><G><Q><W><V><R><M><E><N><V><T><V><L><G><E><D><V><I><V><N><D><E><L><Y><L><N><G><A><S><V><L><P><H><K><S><I><G><E><S><V><P><E><P><R><I><I><M> | Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.<BOP> | Q9Y5P6 |
Q9NPC3 | CIP1_HUMAN | RING-type E3 ubiquitin transferase CCNB1IP1 | Homo | <M><S><L><C><E><D><M><L><L><C><N><Y><R><K><C><R><I><K><L><S><G><Y><A><W><V><T><A><C><S><H><I><F><C><D><Q><H><G><S><G><E><F><S><R><S><P><A><I><C><P><A><C><N><S><T><L><S><G><K><L><D><I><V><R><T><E><L><S><P><S><E><E><Y><K><A><M><V><L><A><G><L><R><P><E><I><V><L><D><I><S><S><R><A><L><A><F><W><T><Y><Q><V><H><Q><E><R><L><Y><Q><E><Y><N><F><S><K><A><E><G><H><L><K><Q><M><E><K><I><Y><T><Q><Q><I><Q><S><K><D><V><E><L><T><S><M><K><G><E><V><T><S><M><K><K><V><L><E><E><Y><K><K><K><F><S><D><I><S><E><K><L><M><E><R><N><R><Q><Y><Q><K><L><Q><G><L><Y><D><S><L><R><L><R><N><I><T><I><A><N><H><E><G><T><L><E><P><S><M><I><A><Q><S><G><V><L><G><F><P><L><G><N><N><S><K><F><P><L><D><N><T><P><V><R><N><R><G><D><G><D><G><D><F><Q><F><R><P><F><F><A><G><S><P><T><A><P><E><P><S><N><S><F><F><S><F><V><S><P><S><R><E><L><E><Q><Q><Q><V><S><S><R><A><F><K><V><K><R><I> | E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.<BOP> | Q9NPC3 |
A6NKF1 | SAC31_HUMAN | SAC3 homology domain-containing protein 1 | Homo | <M><A><G><R><R><A><Q><T><G><S><A><P><P><R><P><A><A><P><H><P><R><P><A><S><R><A><F><P><Q><H><C><R><P><R><D><A><E><R><P><P><S><P><R><S><P><L><M><P><G><C><E><L><P><V><G><T><C><P><D><M><C><P><A><A><E><R><A><Q><R><E><R><E><H><R><L><H><R><L><E><V><V><P><G><C><R><Q><D><P><P><R><A><D><P><Q><R><A><V><K><E><Y><S><R><P><A><A><G><K><P><R><P><P><P><S><Q><L><R><P><P><S><V><L><L><A><T><V><R><Y><L><A><G><E><V><A><E><S><A><D><I><A><R><A><E><V><A><S><F><V><A><D><R><L><R><A><V><L><L><D><L><A><L><Q><G><A><G><D><A><E><A><A><V><V><L><E><A><A><L><A><T><L><L><T><V><V><A><R><L><G><P><D><A><A><R><G><P><A><D><P><V><L><L><Q><A><Q><V><Q><E><G><F><G><S><L><R><R><C><Y><A><R><G><A><G><P><H><P><R><Q><P><A><F><Q><G><L><F><L><L><Y><N><L><G><S><V><E><A><L><H><E><V><L><Q><L><P><A><A><L><R><A><C><P><P><L><R><K><A><L><A><V><D><A><A><F><R><E><G><N><A><A><R><L><F><R><L><L><Q><T><L><P><Y><L><P><S><C><A><V><Q><C><H><V><G><H><A><R><R><E><A><L><A><R><F><A><R><A><F><S><T><P><K><G><Q><T><L><P><L><G><F><M><V><N><L><L><A><L><D><G><L><R><E><A><R><D><L><C><Q><A><H><G><L><P><L><D><G><E><E><R><V><V><F><L><R><G><R><Y><V><E><E><G><L><P><P><A><S><T><C><K><V><L><V><E><S><K><L><R><G><R><T><L><E><E><V><V><M><A><E><E><E><D><E><G><T><D><R><P><G><S><P><A> | Involved in centrosome duplication and mitotic progression.<BOP> | A6NKF1 |
P02748 | CO9_HUMAN | null | Homo | <M><S><A><C><R><S><F><A><V><A><I><C><I><L><E><I><S><I><L><T><A><Q><Y><T><T><S><Y><D><P><E><L><T><E><S><S><G><S><A><S><H><I><D><C><R><M><S><P><W><S><E><W><S><Q><C><D><P><C><L><R><Q><M><F><R><S><R><S><I><E><V><F><G><Q><F><N><G><K><R><C><T><D><A><V><G><D><R><R><Q><C><V><P><T><E><P><C><E><D><A><E><D><D><C><G><N><D><F><Q><C><S><T><G><R><C><I><K><M><R><L><R><C><N><G><D><N><D><C><G><D><F><S><D><E><D><D><C><E><S><E><P><R><P><P><C><R><D><R><V><V><E><E><S><E><L><A><R><T><A><G><Y><G><I><N><I><L><G><M><D><P><L><S><T><P><F><D><N><E><F><Y><N><G><L><C><N><R><D><R><D><G><N><T><L><T><Y><Y><R><R><P><W><N><V><A><S><L><I><Y><E><T><K><G><E><K><N><F><R><T><E><H><Y><E><E><Q><I><E><A><F><K><S><I><I><Q><E><K><T><S><N><F><N><A><A><I><S><L><K><F><T><P><T><E><T><N><K><A><E><Q><C><C><E><E><T><A><S><S><I><S><L><H><G><K><G><S><F><R><F><S><Y><S><K><N><E><T><Y><Q><L><F><L><S><Y><S><S><K><K><E><K><M><F><L><H><V><K><G><E><I><H><L><G><R><F><V><M><R><N><R><D><V><V><L><T><T><T><F><V><D><D><I><K><A><L><P><T><T><Y><E><K><G><E><Y><F><A><F><L><E><T><Y><G><T><H><Y><S><S><S><G><S><L><G><G><L><Y><E><L><I><Y><V><L><D><K><A><S><M><K><R><K><G><V><E><L><K><D><I><K><R><C><L><G><Y><H><L><D><V><S><L><A><F><S><E><I><S><V><G><A><E><F><N><K><D><D><C><V><K><R><G><E><G><R><A><V><N><I><T><S><E><N><L><I><D><D><V><V><S><L><I><R><G><G><T><R><K><Y><A><F><E><L><K><E><K><L><L><R><G><T><V><I><D><V><T><D><F><V><N><W><A><S><S><I><N><D><A><P><V><L><I><S><Q><K><L><S><P><I><Y><N><L><V><P><V><K><M><K><N><A><H><L><K><K><Q><N><L><E><R><A><I><E><D><Y><I><N><E><F><S><V><R><K><C><H><T><C><Q><N><G><G><T><V><I><L><M><D><G><K><C><L><C><A><C><P><F><K><F><E><G><I><A><C><E><I><S><K><Q><K><I><S><E><G><L><P><A><L><E><F><P><N><E><K> | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells . C9 is the pore-forming subunit of the MAC .<BOP> | P02748 |
E7ETH6 | Z587B_HUMAN | Zinc finger protein 587B | Homo | <M><A><V><V><A><T><L><R><L><S><A><Q><G><T><V><T><F><E><D><V><A><V><K><F><T><Q><E><E><W><N><L><L><S><E><A><Q><R><C><L><Y><R><D><V><T><L><E><N><L><A><L><M><S><S><L><G><C><W><C><G><V><E><D><E><A><A><P><S><K><Q><S><I><Y><I><Q><R><E><T><Q><V><R><T><P><V><T><G><V><S><P><K><K><A><H><P><C><E><M><C><G><P><I><L><G><D><I><L><H><V><A><D><H><Q><G><T><H><H><K><Q><K><L><H><R><C><E><A><W><G><N><K><L><Y><D><S><G><N><F><H><Q><H><Q><N><E><H><I><G><E><K><P><Y><R><G><S><V><E><E><A><L><F><V><K><R><C><K><L><H><V><S><G><E><S><S><V><F><S><E><S><G><K><D><F><L><P><R><S><G><L><L><Q><Q><E><A><S><H><T><G><E><K><S><N><S><K><T><E><C><V><S><P><F><Q><C><G><G><A><H><Y><S><H><G><D><S><M><K><H><F><S><T><K><H><I><L><S><Q><H><Q><R><L><L><P><R><E><E><C><Y><V><C><C><E><C><G><K><S><F><S><K><Y><V><S><F><S><N><H><Q><R><V><H><S><G><K><R><P><Y><E><C><G><E><C><E><K><S><F><S><Q><K><S><S><L><I><Q><H><Q><Q><F><H><T><G><G><K><P><Y><G><C><E><E><C><G><K><Y><F><S><L><E><G><Y><L><R><R><H><Q><K><V><H><A><G><K><G><P><Y><E><C><G><E><C><G><K><S><F><S><S><N><V><N><L><K><S><H><Q><R><I><H><T><G><E><R><P><Y><K><C><G><E><C><E><K><S><F><S><R><K><P><S><L><S><Y><H><Q><R><F><G><R><P><R><W><V><D><H><K><D><R><K><E><F><K><T><S><L><G><N><I><V><K><S><C><L><F> | May be involved in transcriptional regulation.<BOP> | E7ETH6 |
Q12908 | NTCP2_HUMAN | Solute carrier family 10 member 2 | Homo | <M><N><D><P><N><S><C><V><D><N><A><T><V><C><S><G><A><S><C><V><V><P><E><S><N><F><N><N><I><L><S><V><V><L><S><T><V><L><T><I><L><L><A><L><V><M><F><S><M><G><C><N><V><E><I><K><K><F><L><G><H><I><K><R><P><W><G><I><C><V><G><F><L><C><Q><F><G><I><M><P><L><T><G><F><I><L><S><V><A><F><D><I><L><P><L><Q><A><V><V><V><L><I><I><G><C><C><P><G><G><T><A><S><N><I><L><A><Y><W><V><D><G><D><M><D><L><S><V><S><M><T><T><C><S><T><L><L><A><L><G><M><M><P><L><C><L><L><I><Y><T><K><M><W><V><D><S><G><S><I><V><I><P><Y><D><N><I><G><T><S><L><V><S><L><V><V><P><V><S><I><G><M><F><V><N><H><K><W><P><Q><K><A><K><I><I><L><K><I><G><S><I><A><G><A><I><L><I><V><L><I><A><V><V><G><G><I><L><Y><Q><S><A><W><I><I><A><P><K><L><W><I><I><G><T><I><F><P><V><A><G><Y><S><L><G><F><L><L><A><R><I><A><G><L><P><W><Y><R><C><R><T><V><A><F><E><T><G><M><Q><N><T><Q><L><C><S><T><I><V><Q><L><S><F><T><P><E><E><L><N><V><V><F><T><F><P><L><I><Y><S><I><F><Q><L><A><F><A><A><I><F><L><G><F><Y><V><A><Y><K><K><C><H><G><K><N><K><A><E><I><P><E><S><K><E><N><G><T><E><P><E><S><S><F><Y><K><A><N><G><G><F><Q><P><D><E><K> | Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine . Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate . Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation .<BOP> | Q12908 |
P09529 | INHBB_HUMAN | Activin beta-B chain | Homo | <M><D><G><L><P><G><R><A><L><G><A><A><C><L><L><L><L><A><A><G><W><L><G><P><E><A><W><G><S><P><T><P><P><P><T><P><A><A><P><P><P><P><P><P><P><G><S><P><G><G><S><Q><D><T><C><T><S><C><G><G><F><R><R><P><E><E><L><G><R><V><D><G><D><F><L><E><A><V><K><R><H><I><L><S><R><L><Q><M><R><G><R><P><N><I><T><H><A><V><P><K><A><A><M><V><T><A><L><R><K><L><H><A><G><K><V><R><E><D><G><R><V><E><I><P><H><L><D><G><H><A><S><P><G><A><D><G><Q><E><R><V><S><E><I><I><S><F><A><E><T><D><G><L><A><S><S><R><V><R><L><Y><F><F><I><S><N><E><G><N><Q><N><L><F><V><V><Q><A><S><L><W><L><Y><L><K><L><L><P><Y><V><L><E><K><G><S><R><R><K><V><R><V><K><V><Y><F><Q><E><Q><G><H><G><D><R><W><N><M><V><E><K><R><V><D><L><K><R><S><G><W><H><T><F><P><L><T><E><A><I><Q><A><L><F><E><R><G><E><R><R><L><N><L><D><V><Q><C><D><S><C><Q><E><L><A><V><V><P><V><F><V><D><P><G><E><E><S><H><R><P><F><V><V><V><Q><A><R><L><G><D><S><R><H><R><I><R><K><R><G><L><E><C><D><G><R><T><N><L><C><C><R><Q><Q><F><F><I><D><F><R><L><I><G><W><N><D><W><I><I><A><P><T><G><Y><Y><G><N><Y><C><E><G><S><C><P><A><Y><L><A><G><V><P><G><S><A><S><S><F><H><T><A><V><V><N><Q><Y><R><M><R><G><L><N><P><G><T><V><N><S><C><C><I><P><T><K><L><S><T><M><S><M><L><Y><F><D><D><E><Y><N><I><V><K><R><D><V><P><N><M><I><V><E><E><C><G><C><A> | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.<BOP> | P09529 |
Q9Y5X5 | NPFF2_HUMAN | Neuropeptide G-protein coupled receptor | Homo | <M><N><S><F><F><G><T><P><A><A><S><W><C><L><L><E><S><D><V><S><S><A><P><D><K><E><A><G><R><E><R><R><A><L><S><V><Q><Q><R><G><G><P><A><W><S><G><S><L><E><W><S><R><Q><S><A><G><D><R><R><R><L><G><L><S><R><Q><T><A><K><S><S><W><S><R><S><R><D><R><T><C><C><C><R><R><A><W><W><I><L><V><P><A><A><D><R><A><R><R><E><R><F><I><M><N><E><K><W><D><T><N><S><S><E><N><W><H><P><I><W><N><V><N><D><T><K><H><H><L><Y><S><D><I><N><I><T><Y><V><N><Y><Y><L><H><Q><P><Q><V><A><A><I><F><I><I><S><Y><F><L><I><F><F><L><C><M><M><G><N><T><V><V><C><F><I><V><M><R><N><K><H><M><H><T><V><T><N><L><F><I><L><N><L><A><I><S><D><L><L><V><G><I><F><C><M><P><I><T><L><L><D><N><I><I><A><G><W><P><F><G><N><T><M><C><K><I><S><G><L><V><Q><G><I><S><V><A><A><S><V><F><T><L><V><A><I><A><V><D><R><F><Q><C><V><V><Y><P><F><K><P><K><L><T><I><K><T><A><F><V><I><I><M><I><I><W><V><L><A><I><T><I><M><S><P><S><A><V><M><L><H><V><Q><E><E><K><Y><Y><R><V><R><L><N><S><Q><N><K><T><S><P><V><Y><W><C><R><E><D><W><P><N><Q><E><M><R><K><I><Y><T><T><V><L><F><A><N><I><Y><L><A><P><L><S><L><I><V><I><M><Y><G><R><I><G><I><S><L><F><R><A><A><V><P><H><T><G><R><K><N><Q><E><Q><W><H><V><V><S><R><K><K><Q><K><I><I><K><M><L><L><I><V><A><L><L><F><I><L><S><W><L><P><L><W><T><L><M><M><L><S><D><Y><A><D><L><S><P><N><E><L><Q><I><I><N><I><Y><I><Y><P><F><A><H><W><L><A><F><G><N><S><S><V><N><P><I><I><Y><G><F><F><N><E><N><F><R><R><G><F><Q><E><A><F><Q><L><Q><L><C><Q><K><R><A><K><P><M><E><A><Y><A><L><K><A><K><S><H><V><L><I><N><T><S><N><Q><L><V><Q><E><S><T><F><Q><N><P><H><G><E><T><L><L><Y><R><K><S><A><E><K><P><Q><Q><E><L><V><M><E><E><L><K><E><T><T><N><S><S><E><I> | Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<BOP> | Q9Y5X5 |
P36551 | HEM6_HUMAN | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial | Homo | <M><A><L><Q><L><G><R><L><S><S><G><P><C><W><L><V><A><R><G><G><C><G><G><P><R><A><W><S><Q><C><G><G><G><G><L><R><A><W><S><Q><R><S><A><A><G><R><V><C><R><P><P><G><P><A><G><T><E><Q><S><R><G><L><G><H><G><S><T><S><R><G><G><P><W><V><G><T><G><L><A><A><A><L><A><G><L><V><G><L><A><T><A><A><F><G><H><V><Q><R><A><E><M><L><P><K><T><S><G><T><R><A><T><S><L><G><R><P><E><E><E><E><D><E><L><A><H><R><C><S><S><F><M><A><P><P><V><T><D><L><G><E><L><R><R><R><P><G><D><M><K><T><K><M><E><L><L><I><L><E><T><Q><A><Q><V><C><Q><A><L><A><Q><V><D><G><G><A><N><F><S><V><D><R><W><E><R><K><E><G><G><G><G><I><S><C><V><L><Q><D><G><C><V><F><E><K><A><G><V><S><I><S><V><V><H><G><N><L><S><E><E><A><A><K><Q><M><R><S><R><G><K><V><L><K><T><K><D><G><K><L><P><F><C><A><M><G><V><S><S><V><I><H><P><K><N><P><H><A><P><T><I><H><F><N><Y><R><Y><F><E><V><E><E><A><D><G><N><K><Q><W><W><F><G><G><G><C><D><L><T><P><T><Y><L><N><Q><E><D><A><V><H><F><H><R><T><L><K><E><A><C><D><Q><H><G><P><D><L><Y><P><K><F><K><K><W><C><D><D><Y><F><F><I><A><H><R><G><E><R><R><G><I><G><G><I><F><F><D><D><L><D><S><P><S><K><E><E><V><F><R><F><V><Q><S><C><A><R><A><V><V><P><S><Y><I><P><L><V><K><K><H><C><D><D><S><F><T><P><Q><E><K><L><W><Q><Q><L><R><R><G><R><Y><V><E><F><N><L><L><Y><D><R><G><T><K><F><G><L><F><T><P><G><S><R><I><E><S><I><L><M><S><L><P><L><T><A><R><W><E><Y><M><H><S><P><S><E><N><S><K><E><A><E><I><L><E><V><L><R><H><P><R><D><W><V><R> | Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX and participates to the sixth step in the heme biosynthetic pathway.<BOP> | P36551 |
Q7L2J0 | MEPCE_HUMAN | Bicoid-interacting protein 3 homolog | Homo | <M><I><E><M><A><A><E><K><E><P><F><L><V><P><A><P><P><P><P><L><K><D><E><S><G><G><G><G><G><P><T><V><P><P><H><Q><E><A><A><S><G><E><L><R><G><G><T><E><R><G><P><G><R><C><A><P><S><A><G><S><P><A><A><A><V><G><R><E><S><P><G><A><A><A><T><S><S><S><G><P><Q><A><Q><Q><H><R><G><G><G><P><Q><A><Q><S><H><G><E><A><R><L><S><D><P><P><G><R><A><A><P><P><D><V><G><E><E><R><R><G><G><G><G><T><E><L><G><P><P><A><P><P><R><P><R><N><G><Y><Q><P><H><R><P><P><G><G><G><G><G><K><R><R><N><S><C><N><V><G><G><G><G><G><G><F><K><H><P><A><F><K><R><R><R><R><V><N><S><D><C><D><S><V><L><P><S><N><F><L><L><G><G><N><I><F><D><P><L><N><L><N><S><L><L><D><E><E><V><S><R><T><L><N><A><E><T><P><K><S><S><P><L><P><A><K><G><R><D><P><V><E><I><L><I><P><K><D><I><T><D><P><L><S><L><N><T><C><T><D><E><G><H><V><V><L><A><S><P><L><K><T><G><R><K><R><H><R><H><R><G><Q><H><H><Q><Q><Q><Q><A><A><G><G><S><E><S><H><P><V><P><P><T><A><P><L><T><P><L><L><H><G><E><G><A><S><Q><Q><P><R><H><R><G><Q><N><R><D><A><P><Q><P><Y><E><L><N><T><A><I><N><C><R><D><E><V><V><S><P><L><P><S><A><L><Q><G><P><S><G><S><L><S><A><P><P><A><A><S><V><I><S><A><P><P><S><S><S><S><R><H><R><K><R><R><R><T><S><S><K><S><E><A><G><A><R><G><G><G><Q><G><S><K><E><K><G><R><G><S><W><G><G><R><H><H><H><H><H><P><L><P><A><A><G><F><K><K><Q><Q><R><K><F><Q><Y><G><N><Y><C><K><Y><Y><G><Y><R><N><P><S><C><E><D><G><R><L><R><V><L><K><P><E><W><F><R><G><R><D><V><L><D><L><G><C><N><V><G><H><L><T><L><S><I><A><C><K><W><G><P><S><R><M><V><G><L><D><I><D><S><R><L><I><H><S><A><R><Q><N><I><R><H><Y><L><S><E><E><L><R><L><P><P><Q><T><L><E><G><D><P><G><A><E><G><E><E><G><T><T><T><V><R><K><R><S><C><F><P><A><S><L><T><A><S><R><G><P><I><A><A><P><Q><V><P><L><D><G><A><D><T><S><V><F><P><N><N><V><V><F><V><T><G><N><Y><V><L><D><R><D><D><L><V><E><A><Q><T><P><E><Y><D><V><V><L><C><L><S><L><T><K><W><V><H><L><N><W><G><D><E><G><L><K><R><M><F><R><R><I><Y><R><H><L><R><P><G><G><I><L><V><L><E><P><Q><P><W><S><S><Y><G><K><R><K><T><L><T><E><T><I><Y><K><N><Y><Y><R><I><Q><L><K><P><E><Q><F><S><S><Y><L><T><S><P><D><V><G><F><S><S><Y><E><L><V><A><T><P><H><N><T><S><K><G><F><Q><R><P><V><Y><L><F><H><K><A><R><S><P><S><H> | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it . Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation . The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) . In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex . MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center .<BOP> | Q7L2J0 |
Q8IWT0 | ARCH_HUMAN | Zinc finger and BTB domain-containing opposite strand protein 8 | Homo | <M><A><Q><E><E><E><D><V><R><D><Y><N><L><T><E><E><Q><K><A><I><K><A><K><Y><P><P><V><N><R><K><Y><E><Y><L><D><H><T><A><D><V><Q><L><H><A><W><G><D><T><L><E><E><A><F><E><Q><C><A><M><A><M><F><G><Y><M><T><D><T><G><T><V><E><P><L><Q><T><V><E><V><E><T><Q><G><D><D><L><Q><S><L><L><F><H><F><L><D><E><W><L><Y><K><F><S><A><D><E><F><F><I><P><R><E><V><K><V><L><S><I><D><Q><R><N><F><K><L><R><S><I><G><W><G><E><E><F><S><L><S><K><H><P><Q><G><T><E><V><K><A><I><T><Y><S><A><M><Q><V><Y><N><E><E><N><P><E><V><F><V><I><I><D><I> | Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.<BOP> | Q8IWT0 |
Q03060 | CREM_HUMAN | Inducible cAMP early repressor | Homo | <M><T><M><E><T><V><E><S><Q><H><D><G><S><I><T><A><S><L><T><E><S><K><S><A><H><V><Q><T><Q><T><G><Q><N><S><I><P><A><L><A><Q><V><S><V><A><G><S><G><T><R><R><G><S><P><A><V><T><L><V><Q><L><P><S><G><Q><T><I><H><V><Q><G><V><I><Q><T><P><Q><P><W><V><I><Q><S><S><E><I><H><T><V><Q><V><A><A><I><A><E><T><D><E><S><A><E><S><E><G><V><I><D><S><H><K><R><R><E><I><L><S><R><R><P><S><Y><R><K><I><L><N><E><L><S><S><D><V><P><G><V><P><K><I><E><E><E><R><S><E><E><E><G><T><P><P><S><I><A><T><M><A><V><P><T><S><I><Y><Q><T><S><T><G><Q><Y><I><A><I><A><Q><G><G><T><I><Q><I><S><N><P><G><S><D><G><V><Q><G><L><Q><A><L><T><M><T><N><S><G><A><P><P><P><G><A><T><I><V><Q><Y><A><A><Q><S><A><D><G><T><Q><Q><F><F><V><P><G><S><Q><V><V><V><Q><D><E><E><T><E><L><A><P><S><H><M><A><A><A><T><G><D><M><P><T><Y><Q><I><R><A><P><T><A><A><L><P><Q><G><V><V><M><A><A><S><P><G><S><L><H><S><P><Q><Q><L><A><E><E><A><T><R><K><R><E><L><R><L><M><K><N><R><E><A><A><K><E><C><R><R><R><K><K><E><Y><V><K><C><L><E><S><R><V><A><V><L><E><V><Q><N><K><K><L><I><E><E><L><E><T><L><K><D><I><C><S><P><K><T><D><Y> | May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.<BOP> | Q03060 |
Q86UZ6 | ZBT46_HUMAN | Zinc finger protein 340 | Homo | <M><N><N><R><K><E><D><M><E><I><T><S><H><Y><R><H><L><L><R><E><L><N><E><Q><R><Q><H><G><V><L><C><D><V><C><V><V><V><E><G><K><V><F><K><A><H><K><N><V><L><L><G><S><S><R><Y><F><K><T><L><Y><C><Q><V><Q><K><T><S><E><Q><A><T><V><T><H><L><D><I><V><T><A><Q><G><F><K><A><I><I><D><F><M><Y><S><A><H><L><A><L><T><S><R><N><V><I><E><V><M><S><A><A><S><F><L><Q><M><T><D><I><V><Q><A><C><H><D><F><I><K><A><A><L><D><I><S><I><K><S><D><A><S><D><E><L><A><E><F><E><I><G><A><S><S><S><S><S><T><E><A><L><I><S><A><V><M><A><G><R><S><I><S><P><W><L><A><R><R><T><S><P><A><N><S><S><G><D><S><A><I><A><S><C><H><D><G><G><S><S><Y><G><K><E><D><Q><E><P><K><A><D><G><P><D><D><V><S><S><Q><P><L><W><P><G><D><V><G><Y><G><P><L><R><I><K><E><E><Q><V><S><P><S><Q><Y><G><G><S><E><L><P><S><A><K><D><G><A><V><Q><N><S><F><S><E><Q><S><A><G><D><A><W><Q><P><T><G><R><R><K><N><R><K><N><K><E><T><V><R><H><I><T><Q><Q><V><E><D><D><S><R><A><S><S><P><V><P><S><F><L><P><T><S><G><W><P><F><S><S><R><D><S><N><A><D><L><S><V><T><E><A><S><S><S><D><S><R><G><E><R><A><E><L><Y><A><Q><V><E><E><G><L><L><G><G><E><A><S><Y><L><G><P><P><L><T><P><E><K><D><D><A><L><H><Q><A><T><A><V><A><N><L><R><A><A><L><M><S><K><N><S><L><L><S><L><K><A><D><V><L><G><D><D><G><S><L><L><F><E><Y><L><P><R><G><A><H><S><L><S><L><N><E><F><T><V><I><R><K><K><F><K><C><P><Y><C><S><F><S><A><M><H><Q><C><I><L><K><R><H><M><R><S><H><T><G><E><R><P><Y><P><C><E><I><C><G><K><K><F><T><R><R><E><H><M><K><R><H><T><L><V><H><S><K><D><K><K><Y><V><C><K><V><C><S><R><V><F><M><S><A><A><S><V><G><I><R><H><G><S><R><R><H><G><V><C><T><D><C><A><G><R><G><M><A><G><P><L><D><H><G><G><G><G><G><E><G><S><P><E><A><L><F><P><G><D><G><P><Y><L><E><D><P><E><D><P><R><G><E><A><E><E><L><G><E><D><D><E><G><L><A><P><E><D><A><L><L><A><D><D><K><D><E><E><D><S><P><R><P><R><S><P><P><G><G><P><D><K><D><F><A><W><L><S> | Functions as a transcriptional repressor for PRDM1.<BOP> | Q86UZ6 |
P50453 | SPB9_HUMAN | Peptidase inhibitor 9 | Homo | <M><E><T><L><S><N><A><S><G><T><F><A><I><R><L><L><K><I><L><C><Q><D><N><P><S><H><N><V><F><C><S><P><V><S><I><S><S><A><L><A><M><V><L><L><G><A><K><G><N><T><A><T><Q><M><A><Q><A><L><S><L><N><T><E><E><D><I><H><R><A><F><Q><S><L><L><T><E><V><N><K><A><G><T><Q><Y><L><L><R><T><A><N><R><L><F><G><E><K><T><C><Q><F><L><S><T><F><K><E><S><C><L><Q><F><Y><H><A><E><L><K><E><L><S><F><I><R><A><A><E><E><S><R><K><H><I><N><T><W><V><S><K><K><T><E><G><K><I><E><E><L><L><P><G><S><S><I><D><A><E><T><R><L><V><L><V><N><A><I><Y><F><K><G><K><W><N><E><P><F><D><E><T><Y><T><R><E><M><P><F><K><I><N><Q><E><E><Q><R><P><V><Q><M><M><Y><Q><E><A><T><F><K><L><A><H><V><G><E><V><R><A><Q><L><L><E><L><P><Y><A><R><K><E><L><S><L><L><V><L><L><P><D><D><G><V><E><L><S><T><V><E><K><S><L><T><F><E><K><L><T><A><W><T><K><P><D><C><M><K><S><T><E><V><E><V><L><L><P><K><F><K><L><Q><E><D><Y><D><M><E><S><V><L><R><H><L><G><I><V><D><A><F><Q><Q><G><K><A><D><L><S><A><M><S><A><E><R><D><L><C><L><S><K><F><V><H><K><S><F><V><E><V><N><E><E><G><T><E><A><A><A><A><S><S><C><F><V><V><A><E><C><C><M><E><S><G><P><R><F><C><A><D><H><P><F><L><F><F><I><R><H><N><R><A><N><S><I><L><F><C><G><R><F><S><S><P> | Granzyme B inhibitor.<BOP> | P50453 |
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