accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
P0DP02
HVC33_HUMAN
Immunoglobulin heavy variable 3-30-3
Homo
<M><E><F><G><L><S><W><V><F><L><V><A><L><L><R><G><V><Q><C><Q><V><Q><L><V><E><S><G><G><G><V><V><Q><P><G><R><S><L><R><L><S><C><A><A><S><G><F><T><F><S><S><Y><A><M><H><W><V><R><Q><A><P><G><K><G><L><E><W><V><A><V><I><S><Y><D><G><S><N><K><Y><Y><A><D><S><V><K><G><R><F><T><I><S><R><D><N><S><K><N><T><L><Y><L><Q><M><N><S><L><R><A><E><D><T><A><V><Y><Y><C><A><R>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P0DP02
Q9BTY2
FUCO2_HUMAN
Alpha-L-fucoside fucohydrolase 2
Homo
<M><R><P><Q><E><L><P><R><L><A><F><P><L><L><L><L><L><L><L><L><L><P><P><P><P><C><P><A><H><S><A><T><R><F><D><P><T><W><E><S><L><D><A><R><Q><L><P><A><W><F><D><Q><A><K><F><G><I><F><I><H><W><G><V><F><S><V><P><S><F><G><S><E><W><F><W><W><Y><W><Q><K><E><K><I><P><K><Y><V><E><F><M><K><D><N><Y><P><P><S><F><K><Y><E><D><F><G><P><L><F><T><A><K><F><F><N><A><N><Q><W><A><D><I><F><Q><A><S><G><A><K><Y><I><V><L><T><S><K><H><H><E><G><F><T><L><W><G><S><E><Y><S><W><N><W><N><A><I><D><E><G><P><K><R><D><I><V><K><E><L><E><V><A><I><R><N><R><T><D><L><R><F><G><L><Y><Y><S><L><F><E><W><F><H><P><L><F><L><E><D><E><S><S><S><F><H><K><R><Q><F><P><V><S><K><T><L><P><E><L><Y><E><L><V><N><N><Y><Q><P><E><V><L><W><S><D><G><D><G><G><A><P><D><Q><Y><W><N><S><T><G><F><L><A><W><L><Y><N><E><S><P><V><R><G><T><V><V><T><N><D><R><W><G><A><G><S><I><C><K><H><G><G><F><Y><T><C><S><D><R><Y><N><P><G><H><L><L><P><H><K><W><E><N><C><M><T><I><D><K><L><S><W><G><Y><R><R><E><A><G><I><S><D><Y><L><T><I><E><E><L><V><K><Q><L><V><E><T><V><S><C><G><G><N><L><L><M><N><I><G><P><T><L><D><G><T><I><S><V><V><F><E><E><R><L><R><Q><M><G><S><W><L><K><V><N><G><E><A><I><Y><E><T><H><T><W><R><S><Q><N><D><T><V><T><P><D><V><W><Y><T><S><K><P><K><E><K><L><V><Y><A><I><F><L><K><W><P><T><S><G><Q><L><F><L><G><H><P><K><A><I><L><G><A><T><E><V><K><L><L><G><H><G><Q><P><L><N><W><I><S><L><E><Q><N><G><I><M><V><E><L><P><Q><L><T><I><H><Q><M><P><C><K><W><G><W><A><L><A><L><T><N><V><I>
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.<BOP>
Q9BTY2
P23434
GCSH_HUMAN
Lipoic acid-containing protein
Homo
<M><A><L><R><V><V><R><S><V><R><A><L><L><C><T><L><R><A><V><P><S><P><A><A><P><C><P><P><R><P><W><Q><L><G><V><G><A><V><R><T><L><R><T><G><P><A><L><L><S><V><R><K><F><T><E><K><H><E><W><V><T><T><E><N><G><I><G><T><V><G><I><S><N><F><A><Q><E><A><L><G><D><V><V><Y><C><S><L><P><E><V><G><T><K><L><N><K><Q><D><E><F><G><A><L><E><S><V><K><A><A><S><E><L><Y><S><P><L><S><G><E><V><T><E><I><N><E><A><L><A><E><N><P><G><L><V><N><K><S><C><Y><E><D><G><W><L><I><K><M><T><L><S><N><P><S><E><L><D><E><L><M><S><E><E><A><Y><E><K><Y><I><K><S><I><E><E>
The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).<BOP>
P23434
Q99986
VRK1_HUMAN
Vaccinia-related kinase 1
null
<M><P><R><V><K><A><A><Q><A><G><R><Q><S><S><A><K><R><H><L><A><E><Q><F><A><V><G><E><I><I><T><D><M><A><K><K><E><W><K><V><G><L><P><I><G><Q><G><G><F><G><C><I><Y><L><A><D><M><N><S><S><E><S><V><G><S><D><A><P><C><V><V><K><V><E><P><S><D><N><G><P><L><F><T><E><L><K><F><Y><Q><R><A><A><K><P><E><Q><I><Q><K><W><I><R><T><R><K><L><K><Y><L><G><V><P><K><Y><W><G><S><G><L><H><D><K><N><G><K><S><Y><R><F><M><I><M><D><R><F><G><S><D><L><Q><K><I><Y><E><A><N><A><K><R><F><S><R><K><T><V><L><Q><L><S><L><R><I><L><D><I><L><E><Y><I><H><E><H><E><Y><V><H><G><D><I><K><A><S><N><L><L><L><N><Y><K><N><P><D><Q><V><Y><L><V><D><Y><G><L><A><Y><R><Y><C><P><E><G><V><H><K><E><Y><K><E><D><P><K><R><C><H><D><G><T><I><E><F><T><S><I><D><A><H><N><G><V><A><P><S><R><R><G><D><L><E><I><L><G><Y><C><M><I><Q><W><L><T><G><H><L><P><W><E><D><N><L><K><D><P><K><Y><V><R><D><S><K><I><R><Y><R><E><N><I><A><S><L><M><D><K><C><F><P><E><K><N><K><P><G><E><I><A><K><Y><M><E><T><V><K><L><L><D><Y><T><E><K><P><L><Y><E><N><L><R><D><I><L><L><Q><G><L><K><A><I><G><S><K><D><D><G><K><L><D><L><S><V><V><E><N><G><G><L><K><A><K><T><I><T><K><K><R><K><K><E><I><E><E><S><K><E><P><G><V><E><D><T><E><W><S><N><T><Q><T><E><E><A><I><Q><T><R><S><R><T><R><K><R><V><Q><K>
Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation . Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation . Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2 . Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity . Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm . Phosphorylates ATF2 which activates its transcriptional activity .<BOP>
Q99986
Q15025
TNIP1_HUMAN
Virion-associated nuclear shuttling protein
Homo
<M><E><G><R><G><P><Y><R><I><Y><D><P><G><G><S><V><P><S><G><E><A><S><A><A><F><E><R><L><V><K><E><N><S><R><L><K><E><K><M><Q><G><I><K><M><L><G><E><L><L><E><E><S><Q><M><E><A><T><R><L><R><Q><K><A><E><E><L><V><K><D><N><E><L><L><P><P><P><S><P><S><L><G><S><F><D><P><L><A><E><L><T><G><K><D><S><N><V><T><A><S><P><T><A><P><A><C><P><S><D><K><P><A><P><V><Q><K><P><P><S><S><G><T><S><S><E><F><E><V><V><T><P><E><E><Q><N><S><P><E><S><S><S><H><A><N><A><M><A><L><G><P><L><P><R><E><D><G><N><L><M><L><H><L><Q><R><L><E><T><T><L><S><V><C><A><E><E><P><D><H><G><Q><L><F><T><H><L><G><R><M><A><L><E><F><N><R><L><A><S><K><V><H><K><N><E><Q><R><T><S><I><L><Q><T><L><C><E><Q><L><R><K><E><N><E><A><L><K><A><K><L><D><K><G><L><E><Q><R><D><Q><A><A><E><R><L><R><E><E><N><L><E><L><K><K><L><L><M><S><N><G><N><K><E><G><A><S><G><R><P><G><S><P><K><M><E><G><T><G><K><K><A><V><A><G><Q><Q><Q><A><S><V><T><A><G><K><V><P><E><V><V><A><L><G><A><A><E><K><K><V><K><M><L><E><Q><Q><R><S><E><L><L><E><V><N><K><Q><W><D><Q><H><F><R><S><M><K><Q><Q><Y><E><Q><K><I><T><E><L><R><Q><K><L><A><D><L><Q><K><Q><V><T><D><L><E><A><E><R><E><Q><K><Q><R><D><F><D><R><K><L><L><L><A><K><S><K><I><E><M><E><E><T><D><K><E><Q><L><T><A><E><A><K><E><L><R><Q><K><V><K><Y><L><Q><D><Q><L><S><P><L><T><R><Q><R><E><Y><Q><E><K><E><I><Q><R><L><N><K><A><L><E><E><A><L><S><I><Q><T><P><P><S><S><P><P><T><A><F><G><S><P><E><G><A><G><A><L><L><R><K><Q><E><L><V><T><Q><N><E><L><L><K><Q><Q><V><K><I><F><E><E><D><F><Q><R><E><R><S><D><R><E><R><M><N><E><E><K><E><E><L><K><K><Q><V><E><K><L><Q><A><Q><V><T><L><S><N><A><Q><L><K><A><F><K><D><E><E><K><A><R><E><A><L><R><Q><Q><K><R><K><A><K><A><S><G><E><R><Y><H><V><E><P><H><P><E><H><L><C><G><A><Y><P><Y><A><Y><P><P><M><P><A><M><V><P><H><H><G><F><E><D><W><S><Q><I><R><Y><P><P><P><P><M><A><M><E><H><P><P><P><L><P><N><S><R><L><F><H><L><P><E><Y><T><W><R><L><P><C><G><G><V><R><N><P><N><Q><S><S><Q><V><M><D><P><P><T><A><R><P><T><E><P><E><S><P><K><N><D><R><E><G><P><Q>
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3
Q15025
P28907
CD38_HUMAN
T10
Homo
<M><A><N><C><E><F><S><P><V><S><G><D><K><P><C><C><R><L><S><R><R><A><Q><L><C><L><G><V><S><I><L><V><L><I><L><V><V><V><L><A><V><V><V><P><R><W><R><Q><Q><W><S><G><P><G><T><T><K><R><F><P><E><T><V><L><A><R><C><V><K><Y><T><E><I><H><P><E><M><R><H><V><D><C><Q><S><V><W><D><A><F><K><G><A><F><I><S><K><H><P><C><N><I><T><E><E><D><Y><Q><P><L><M><K><L><G><T><Q><T><V><P><C><N><K><I><L><L><W><S><R><I><K><D><L><A><H><Q><F><T><Q><V><Q><R><D><M><F><T><L><E><D><T><L><L><G><Y><L><A><D><D><L><T><W><C><G><E><F><N><T><S><K><I><N><Y><Q><S><C><P><D><W><R><K><D><C><S><N><N><P><V><S><V><F><W><K><T><V><S><R><R><F><A><E><A><A><C><D><V><V><H><V><M><L><N><G><S><R><S><K><I><F><D><K><N><S><T><F><G><S><V><E><V><H><N><L><Q><P><E><K><V><Q><T><L><E><A><W><V><I><H><G><G><R><E><D><S><R><D><L><C><Q><D><P><T><I><K><E><L><E><S><I><I><S><K><R><N><I><Q><F><S><C><K><N><I><Y><R><P><D><K><F><L><Q><C><V><K><N><P><E><D><S><S><C><T><S><E><I>
Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.<BOP>
P28907
Q8TC36
SUN5_HUMAN
Testis and spermatogenesis-related gene 4 protein
Homo
<M><P><R><S><S><R><S><P><G><D><P><G><A><L><L><E><D><V><A><H><N><P><R><P><R><R><I><A><Q><R><G><R><N><T><S><R><M><A><E><D><T><S><P><N><M><N><D><N><I><L><L><P><V><R><N><N><D><Q><A><L><G><L><T><Q><C><M><L><G><C><V><S><W><F><T><C><F><A><C><S><L><R><T><Q><A><Q><Q><V><L><F><N><T><C><R><C><K><L><L><C><Q><K><L><M><E><K><T><G><I><L><L><L><C><A><F><G><F><W><M><F><S><I><H><L><P><S><K><M><K><V><W><Q><D><D><S><I><N><G><P><L><Q><S><L><R><L><Y><Q><E><K><V><R><H><H><S><G><E><I><Q><D><L><R><G><S><M><N><Q><L><I><A><K><L><Q><E><M><E><A><M><S><D><E><Q><K><M><A><Q><K><I><M><K><M><I><H><G><D><Y><I><E><K><P><D><F><A><L><K><S><I><G><A><S><I><D><F><E><H><T><S><V><T><Y><N><H><E><K><A><H><S><Y><W><N><W><I><Q><L><W><N><Y><A><Q><P><P><D><V><I><L><E><P><N><V><T><P><G><N><C><W><A><F><E><G><D><R><G><Q><V><T><I><Q><L><A><Q><K><V><Y><L><S><N><L><T><L><Q><H><I><P><K><T><I><S><L><S><G><S><L><D><T><A><P><K><D><F><V><I><Y><G><M><E><G><S><P><K><E><E><V><F><L><G><A><F><Q><F><Q><P><E><N><I><I><Q><M><F><P><L><Q><N><Q><P><A><R><A><F><S><A><V><K><V><K><I><S><S><N><W><G><N><P><G><F><T><C><L><Y><R><V><R><V><H><G><S><V><A><P><P><R><E><Q><P><H><Q><N><P><Y><P><K><R><D>
Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope.<BOP>
Q8TC36
Q8N7K0
ZN433_HUMAN
Zinc finger protein 433
Homo
<M><M><F><Q><D><S><V><A><F><E><D><V><A><V><T><F><T><Q><E><E><W><A><L><L><D><P><S><Q><K><N><L><C><R><D><V><M><Q><E><T><F><R><N><L><A><S><I><G><K><K><W><K><P><Q><N><I><Y><V><E><Y><E><N><L><R><R><N><L><R><I><V><G><E><R><L><F><E><S><K><E><G><H><Q><H><G><E><I><L><T><Q><V><P><D><D><M><L><K><K><T><T><T><G><V><K><S><C><E><S><S><V><Y><G><E><V><G><S><A><H><S><S><L><N><R><H><I><R><D><D><T><G><H><K><A><Y><E><Y><Q><E><Y><G><Q><K><P><Y><K><C><K><Y><C><K><K><P><F><N><C><L><S><S><V><Q><T><H><E><R><A><H><S><G><R><K><L><Y><V><C><E><E><C><G><K><T><F><I><S><H><S><N><L><Q><R><H><R><I><M><H><R><G><D><G><P><Y><K><C><K><F><C><G><K><A><L><M><F><L><S><L><Y><L><I><H><K><R><T><H><T><G><E><K><P><Y><Q><C><K><Q><C><G><K><A><F><S><H><S><S><S><L><R><I><H><E><R><T><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><H><S><S><T><C><L><H><A><H><K><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><S><S><H><S><F><Q><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><K><C><P><S><S><V><R><R><H><E><R><T><H><S><R><K><K><P><Y><E><C><K><H><C><G><K><V><L><S><Y><L><T><S><F><Q><N><H><L><G><M><H><T><G><E><I><S><H><K><C><K><I><C><G><K><A><F><Y><S><P><S><S><L><Q><T><H><E><K><T><H><T><G><E><K><P><Y><K><C><N><Q><C><G><K><A><F><N><S><S><S><S><F><R><Y><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><A><S><L><L><Q><T><H><G><R><T><H><T><G><E><K><P><Y><A><C><K><E><C><G><K><P><F><S><N><F><S><F><F><Q><I><H><E><R><M><H><R><E><E><K><P><Y><E><C><K><G><Y><G><K><T><F><S><L><P><S><L><F><H><R><H><E><R><T><H><T><G><G><K><T><Y><E><C><K><Q><C><G><R><S><F><N><C><S><S><S><F><R><Y><H><G><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><A><S><Q><L><Q><I><H><G><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><G><S><A><S><H><L><Q><M><H><G><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><S><F><G><C><A><S><R><L><Q><M><H><G><R><T><H><T><G><E><K><P><Y><K><C><K><Q><C><G><K><A><F><G><C><P><S><N><L><R><R><H><G><R><T><H><T><G><E><K><P><Y><K><C><N><Q><C><G><K><V><F><R><C><S><S><Q><L><Q><V><H><G><R><A><H><C><I><D><T><P>
May be involved in transcriptional regulation.<BOP>
Q8N7K0
Q9UHV8
PP13_HUMAN
Placental tissue protein 13
Homo
<M><S><S><L><P><V><P><Y><K><L><P><V><S><L><S><V><G><S><C><V><I><I><K><G><T><P><I><H><S><F><I><N><D><P><Q><L><Q><V><D><F><Y><T><D><M><D><E><D><S><D><I><A><F><R><F><R><V><H><F><G><N><H><V><V><M><N><R><R><E><F><G><I><W><M><L><E><E><T><T><D><Y><V><P><F><E><D><G><K><Q><F><E><L><C><I><Y><V><H><Y><N><E><Y><E><I><K><V><N><G><I><R><I><Y><G><F><V><H><R><I><P><P><S><F><V><K><M><V><Q><V><S><R><D><I><S><L><T><S><V><C><V><C><N>
Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis . Has hemagglutinating activity towards chicken erythrocytes .<BOP>
Q9UHV8
Q8WVV4
POF1B_HUMAN
Premature ovarian failure protein 1B
Homo
<M><S><S><S><Y><W><S><E><T><S><S><S><S><C><G><T><Q><Q><L><P><E><V><L><Q><C><Q><P><Q><H><Y><H><C><Y><H><Q><S><S><Q><A><Q><Q><P><P><E><K><N><V><V><Y><E><R><V><R><T><Y><S><G><P><M><N><K><V><V><Q><A><L><D><P><F><N><S><R><E><V><L><S><P><L><K><T><T><S><S><Y><Q><N><L><V><W><S><D><H><S><Q><E><L><H><S><P><T><L><K><I><S><T><C><A><P><S><T><L><H><I><T><Q><N><T><E><Q><E><L><H><S><P><T><V><K><L><T><T><Y><P><Q><T><T><I><R><K><Y><V><V><Q><N><P><E><Q><E><P><L><S><Q><F><L><R><G><S><H><F><F><P><G><N><N><V><I><Y><E><K><T><I><R><K><V><E><K><L><N><T><D><Q><G><C><H><P><Q><A><Q><C><H><H><H><I><I><Q><Q><P><Q><V><I><H><S><A><H><W><Q><Q><P><D><S><S><Q><Q><I><Q><A><I><T><G><N><N><P><I><S><T><H><I><G><N><E><L><C><H><S><G><S><S><Q><I><C><E><Q><V><I><I><Q><D><D><G><P><E><K><L><D><P><R><Y><F><G><E><L><L><A><D><L><S><R><K><N><T><D><L><Y><H><C><L><L><E><H><L><Q><R><I><G><G><S><K><Q><D><F><E><S><T><D><E><S><E><D><I><E><S><L><I><P><K><G><L><S><E><F><T><K><Q><Q><I><R><Y><I><L><Q><M><R><G><M><S><D><K><S><L><R><L><V><L><S><T><F><S><N><I><R><E><E><L><G><H><L><Q><N><D><M><T><S><L><E><N><D><K><M><R><L><E><K><D><L><S><F><K><D><T><Q><L><K><E><Y><E><E><L><L><A><S><V><R><A><N><N><H><Q><Q><Q><Q><G><L><Q><D><S><S><S><K><C><Q><A><L><E><E><N><N><L><S><L><R><H><T><L><S><D><M><E><Y><R><L><K><E><L><E><Y><C><K><R><N><L><E><Q><E><N><Q><N><L><R><M><Q><V><S><E><T><C><T><G><P><M><L><Q><A><K><M><D><E><I><G><N><H><Y><T><E><M><V><K><N><L><R><M><E><K><D><R><E><I><C><R><L><R><S><Q><L><N><Q><Y><H><K><D><V><S><K><R><E><G><S><C><S><D><F><Q><F><K><L><H><E><L><T><S><L><L><E><E><K><D><S><L><I><K><R><Q><S><E><E><L><S><K><L><R><Q><E><I><Y><S><S><H><N><Q><P><S><T><G><G><R><T><T><I><T><T><K><K><Y><R><T><Q><Y><P><I><L><G><L><L><Y><D><D><Y><E><Y><I><P><P><G><S><E><T><Q><T><I><V><I><E><K><T><E><D><K><Y><T><C><P>
Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development.<BOP>
Q8WVV4
P15622
ZN250_HUMAN
Zinc finger protein 647
Homo
<M><A><A><A><R><L><L><P><V><P><A><G><P><Q><P><L><S><F><Q><A><K><L><T><F><E><D><V><A><V><L><L><S><Q><D><E><W><D><R><L><C><P><A><Q><R><G><L><Y><R><N><V><M><M><E><T><Y><G><N><V><V><S><L><G><L><P><G><S><K><P><D><I><I><S><Q><L><E><R><G><E><D><P><W><V><L><D><R><K><G><A><K><K><S><Q><G><L><W><S><D><Y><S><D><N><L><K><Y><D><H><T><T><A><C><T><Q><Q><D><S><L><S><C><P><W><E><C><E><T><K><G><E><S><Q><N><T><D><L><S><P><K><P><L><I><S><E><Q><T><V><I><L><G><K><T><P><L><G><R><I><D><Q><E><N><N><E><T><K><Q><S><F><C><L><S><P><N><S><V><D><H><R><E><V><Q><V><L><S><Q><S><M><P><L><T><P><H><Q><A><V><P><S><G><E><R><P><Y><M><C><V><E><C><G><K><C><F><G><R><S><S><H><L><L><Q><H><Q><R><I><H><T><G><E><K><P><Y><V><C><S><V><C><G><K><A><F><S><Q><S><S><V><L><S><K><H><R><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><R><V><S><S><D><L><A><Q><H><H><K><I><H><T><G><E><K><P><H><E><C><L><E><C><R><K><A><F><T><Q><L><S><H><L><I><Q><H><Q><R><I><H><T><G><E><R><P><Y><V><C><P><L><C><G><K><A><F><N><H><S><T><V><L><R><S><H><Q><R><V><H><T><G><E><K><P><H><R><C><N><E><C><G><K><T><F><S><V><K><R><T><L><L><Q><H><Q><R><I><H><T><G><E><K><P><Y><T><C><S><E><C><G><K><A><F><S><D><R><S><V><L><I><Q><H><H><N><V><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><T><F><S><H><R><S><T><L><M><N><H><E><R><I><H><T><E><E><K><P><Y><A><C><Y><E><C><G><K><A><F><V><Q><H><S><H><L><I><Q><H><Q><R><V><H><T><G><E><K><P><Y><V><C><G><E><C><G><H><A><F><S><A><R><R><S><L><I><Q><H><E><R><I><H><T><G><E><K><P><F><Q><C><T><E><C><G><K><A><F><S><L><K><A><T><L><I><V><H><L><R><T><H><T><G><E><K><P><Y><E><C><N><S><C><G><K><A><F><S><Q><Y><S><V><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><G><E><C><G><R><A><F><N><Q><H><G><H><L><I><Q><H><Q><K><V><H><R><K><L>
May be involved in transcriptional regulation.<BOP>
P15622
P32780
TF2H1_HUMAN
TFIIH basal transcription factor complex p62 subunit
Homo
<M><A><T><S><S><E><E><V><L><L><I><V><K><K><V><R><Q><K><K><Q><D><G><A><L><Y><L><M><A><E><R><I><A><W><A><P><E><G><K><D><R><F><T><I><S><H><M><Y><A><D><I><K><C><Q><K><I><S><P><E><G><K><A><K><I><Q><L><Q><L><V><L><H><A><G><D><T><T><N><F><H><F><S><N><E><S><T><A><V><K><E><R><D><A><V><K><D><L><L><Q><Q><L><L><P><K><F><K><R><K><A><N><K><E><L><E><E><K><N><R><M><L><Q><E><D><P><V><L><F><Q><L><Y><K><D><L><V><V><S><Q><V><I><S><A><E><E><F><W><A><N><R><L><N><V><N><A><T><D><S><S><S><T><S><N><H><K><Q><D><V><G><I><S><A><A><F><L><A><D><V><R><P><Q><T><D><G><C><N><G><L><R><Y><N><L><T><S><D><I><I><E><S><I><F><R><T><Y><P><A><V><K><M><K><Y><A><E><N><V><P><H><N><M><T><E><K><E><F><W><T><R><F><F><Q><S><H><Y><F><H><R><D><R><L><N><T><G><S><K><D><L><F><A><E><C><A><K><I><D><E><K><G><L><K><T><M><V><S><L><G><V><K><N><P><L><L><D><L><T><A><L><E><D><K><P><L><D><E><G><Y><G><I><S><S><V><P><S><A><S><N><S><K><S><I><K><E><N><S><N><A><A><I><I><K><R><F><N><H><H><S><A><M><V><L><A><A><G><L><R><K><Q><E><A><Q><N><E><Q><T><S><E><P><S><N><M><D><G><N><S><G><D><A><D><C><F><Q><P><A><V><K><R><A><K><L><Q><E><S><I><E><Y><E><D><L><G><K><N><N><S><V><K><T><I><A><L><N><L><K><K><S><D><R><Y><Y><H><G><P><T><P><I><Q><S><L><Q><Y><A><T><S><Q><D><I><I><N><S><F><Q><S><I><R><Q><E><M><E><A><Y><T><P><K><L><T><Q><V><L><S><S><S><A><A><S><S><T><I><T><A><L><S><P><G><G><A><L><M><Q><G><G><T><Q><Q><A><I><N><Q><M><V><P><N><D><I><Q><S><E><L><K><H><L><Y><V><A><V><G><E><L><L><R><H><F><W><S><C><F><P><V><N><T><P><F><L><E><E><K><V><V><K><M><K><S><N><L><E><R><F><Q><V><T><K><L><C><P><F><Q><E><K><I><R><R><Q><Y><L><S><T><N><L><V><S><H><I><E><E><M><L><Q><T><A><Y><N><K><L><H><T><W><Q><S><R><R><L><M><K><K><T>
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.<BOP>
P32780
Q13956
CNCG_HUMAN
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Homo
<M><S><D><N><T><T><L><P><A><P><A><S><N><Q><G><P><T><T><P><R><K><G><P><P><K><F><K><Q><R><Q><T><R><Q><F><K><S><K><P><P><K><K><G><V><K><G><F><G><D><D><I><P><G><M><E><G><L><G><T><D><I><T><V><I><C><P><W><E><A><F><S><H><L><E><L><H><E><L><A><Q><F><G><I><I>
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.<BOP>
Q13956
O95222
OR6A2_HUMAN
hP2 olfactory receptor
Homo
<M><E><W><R><N><H><S><G><R><V><S><E><F><V><L><L><G><F><P><A><P><A><P><L><Q><V><L><L><F><A><L><L><L><L><A><Y><V><L><V><L><T><E><N><T><L><I><I><M><A><I><R><N><H><S><T><L><H><K><P><M><Y><F><F><L><A><N><M><S><F><L><E><I><W><Y><V><T><V><T><I><P><K><M><L><A><G><F><V><G><S><K><Q><D><H><G><Q><L><I><S><F><E><G><C><M><T><Q><L><Y><F><F><L><G><L><G><C><T><E><C><V><L><L><A><V><M><A><Y><D><R><Y><M><A><I><C><Y><P><L><H><Y><P><V><I><V><S><G><R><L><C><V><Q><M><A><A><G><S><W><A><G><G><F><G><I><S><M><V><K><V><F><L><I><S><G><L><S><Y><C><G><P><N><I><I><N><H><F><F><C><D><V><S><P><L><L><N><L><S><C><T><D><M><S><T><A><E><L><T><D><F><I><L><A><I><F><I><L><L><G><P><L><S><V><T><G><A><S><Y><V><A><I><T><G><A><V><M><H><I><P><S><A><A><G><R><Y><K><A><F><S><T><C><A><S><H><L><T><V><V><I><I><F><Y><A><A><S><I><F><I><Y><A><R><P><K><A><L><S><A><F><D><T><N><K><L><V><S><V><L><Y><A><V><I><V><P><L><L><N><P><I><I><Y><C><L><R><N><Q><E><V><K><R><A><L><C><C><T><L><H><L><Y><Q><H><Q><D><P><D><P><K><K><A><S><R><N><V>
Odorant receptor.<BOP>
O95222
Q8N5I3
KCNRG_HUMAN
Protein CLLD4
Homo
<M><S><S><Q><E><L><V><T><L><N><V><G><G><K><I><F><T><T><R><F><S><T><I><K><Q><F><P><A><S><R><L><A><R><M><L><D><G><R><D><Q><E><F><K><M><V><G><G><Q><I><F><V><D><R><D><G><D><L><F><S><F><I><L><D><F><L><R><T><H><Q><L><L><L><P><T><E><F><S><D><Y><L><R><L><Q><R><E><A><L><F><Y><E><L><R><S><L><V><D><L><L><N><P><Y><L><L><Q><P><R><P><A><L><V><E><V><H><F><L><S><R><N><T><Q><A><F><F><R><V><F><G><S><C><S><K><T><I><E><M><L><T><G><R><I><T><V><F><T><E><Q><P><S><A><P><T><W><N><G><N><F><F><P><P><Q><M><T><L><L><P><L><P><P><Q><R><P><S><Y><H><D><L><V><F><Q><C><G><S><D><S><T><T><D><N><Q><T><G><V><R><Y><V><S><I><K><P><D><N><R><K><L><A><N><G><T><N><V><L><G><L><L><I><D><T><L><L><K><E><G><F><H><L><V><S><T><R><T><V><S><S><E><D><K><T><E><C><Y><S><F><E><R><I><K><S><P><E><V><L><I><T><N><E><T><P><K><P><E><T><I><I><I><P><E><Q><S><Q><I><K><K>
Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.<BOP>
Q8N5I3
P86397
HTD2_HUMAN
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Homo
<M><F><P><L><I><S><S><H><H><L><W><W><G><G><L><R><R><T><V><C><L><N><L><P><V><L><T><L><Q><H><F><Q><H><M><H><I><K><V><G><D><R><A><E><L><R><R><A><F><T><Q><T><D><V><A><T><F><S><E><L><T><G><D><V><N><P><L><H><L><N><E><D><F><A><K><H><T><K><F><G><N><T><I><V><H><G><V><L><I><N><G><L><I><S><A><L><L><G><T><K><M><P><G><P><G><C><V><F><L><S><Q><E><I><S><F><P><A><P><L><Y><I><G><E><V><V><L><A><S><A><E><V><K><K><L><K><R><F><I><A><I><I><A><V><S><C><S><V><I><E><S><K><K><T><V><M><E><G><W><V><K><V><M><V><P><E><A><S><K><S>
Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis.<BOP>
P86397
Q8NDZ4
DIK2A_HUMAN
Hypoxia and AKT-induced stem cell factor
Homo
<M><W><R><L><V><P><P><K><L><G><R><L><S><R><S><L><K><L><A><A><L><G><S><L><L><V><L><M><V><L><H><S><P><S><L><L><A><S><W><Q><R><N><E><L><T><D><R><R><F><L><Q><L><N><K><C><P><A><C><F><G><T><S><W><C><R><R><F><L><N><G><Q><V><V><F><E><A><W><G><R><L><R><L><L><D><F><L><N><V><K><N><V><Y><F><A><Q><Y><G><E><P><R><E><G><G><R><R><R><V><V><L><K><R><L><G><S><Q><R><E><L><A><Q><L><D><Q><S><I><C><K><R><A><T><G><R><P><R><C><D><L><L><Q><A><M><P><R><T><E><F><A><R><L><N><G><D><V><R><L><L><T><P><E><A><V><E><G><W><S><D><L><V><H><C><P><S><Q><R><L><L><D><R><L><V><R><R><Y><A><E><T><K><D><S><G><S><F><L><L><R><N><L><K><D><S><E><R><M><Q><L><L><L><T><L><A><F><N><P><E><P><L><V><L><Q><S><F><P><S><D><E><G><W><P><F><A><K><Y><L><G><A><C><G><R><M><V><A><V><N><Y><V><G><E><E><L><W><S><Y><F><N><A><P><W><E><K><R><V><D><L><A><W><Q><L><M><E><I><A><E><Q><L><T><N><N><D><F><E><F><A><L><Y><L><L><D><V><S><F><D><N><F><A><V><G><P><R><D><G><K><V><I><I><V><D><A><E><N><V><L><V><A><D><K><R><L><I><R><Q><N><K><P><E><N><W><D><V><W><Y><E><S><K><F><D><D><C><D><K><E><A><C><L><S><F><S><K><E><I><L><C><A><R><A><T><V><D><H><N><Y><Y><A><V><C><Q><N><L><L><S><R><H><A><T><W><R><G><T><S><G><G><L><L><H><D><P><P><S><E><I><A><K><D><G><R><L><E><A><L><L><D><E><C><A><N><P><K><K><R><Y><G><R><F><Q><A><A><K><E><L><R><E><Y><L><A><Q><L><S><N><N><V><R>
May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade.<BOP>
Q8NDZ4
Q6P461
ACSM6_HUMAN
Acyl-CoA synthetase medium-chain family member 6
Homo
<M><L><G><R><F><Q><P><F><S><L><V><R><S><F><R><L><G><F><E><A><C><C><Y><P><N><Q><K><C><A><T><Q><T><I><R><P><P><D><S><R><C><L><V><Q><A><V><S><Q><N><F><N><F><A><K><D><V><L><D><Q><W><S><Q><L><E><K><D><G><L><R><G><P><Y><P><A><L><W><K><V><S><A><K><G><E><E><D><K><W><S><F><E><R><M><T><Q><L><S><K><K><A><A><S><I><L><S><D><T><C><A><L><S><H><G><D><R><L><M><I><I><L><P><P><T><P><E><A><Y><W><I><C><L><A><C><V><R><L><G><I><T><F><V><P><G><S><P><Q><L><T><A><K><K><I><R><Y><Q><L><R><M><S><K><A><Q><C><I><V><A><N><E><A><M><A><P><V><V><N><S><A><V><S><D><C><P><T><L><K><T><K><L><L><V><S><D><K><S><Y><D><G><W><L><D><F><K><K><L><I><Q><V><A><P><P><K><Q><T><Y><M><R><T><K><S><Q><D><P><M><A><I><F><F><T><K><G><T><T><G><A><P><K><M><V><E><Y><S><Q><Y><G><L><G><M><G><F><S><Q><A><S><R><R><W><M><D><L><Q><P><T><D><V><L><W><S><L><G><D><A><F><G><G><S><L><S><L><S><A><V><L><G><T><W><F><Q><G><A><C><V><F><L><C><H><M><P><T><F><C><P><E><T><V><L><N><V><L><S><R><F><P><I><T><T><L><S><A><N><P><E><M><Y><Q><E><L><L><Q><H><K><C><F><T><S><Y><R><F><K><S><L><K><Q><C><V><A><A><G><G><P><I><S><P><G><V><I><E><D><W><K><R><I><T><K><L><D><I><Y><E><G><Y><G><Q><T><E><T><G><L><L><C><A><T><S><K><T><I><K><L><K><P><S><S><L><G><K><P><L><P><P><Y><I><V><Q><I><V><D><E><N><S><N><L><L><P><P><G><E><E><G><N><I><A><I><R><I><K><L><N><Q><P><A><S><L><Y><C><P><H><M><V><S><W><E><E><Y><A><S><A><R><G><H><M><L><Y><L><T><G><D><R><G><I><M><D><E><D><G><Y><F><W><W><S><G><R><V><D><D><V><A><N><A><L><G><Q><R><L>
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism.<BOP>
Q6P461
P61077
UB2D3_HUMAN
Ubiquitin-protein ligase D3
Homo
<M><A><L><K><R><I><N><K><E><L><S><D><L><A><R><D><P><P><A><Q><C><S><A><G><P><V><G><D><D><M><F><H><W><Q><A><T><I><M><G><P><N><D><S><P><Y><Q><G><G><V><F><F><L><T><I><H><F><P><T><D><Y><P><F><K><P><P><K><V><A><F><T><T><R><I><Y><H><P><N><I><N><S><N><G><S><I><C><L><D><I><L><R><S><Q><W><S><P><A><L><T><I><S><K><V><L><L><S><I><C><S><L><L><C><D><P><N><P><D><D><P><L><V><P><E><I><A><R><I><Y><K><T><D><R><D><K><Y><N><R><I><S><R><E><W><T><Q><K><Y><A><M>
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD
P61077
P53582
MAP11_HUMAN
Peptidase M 1
Homo
<M><A><A><V><E><T><R><V><C><E><T><D><G><C><S><S><E><A><K><L><Q><C><P><T><C><I><K><L><G><I><Q><G><S><Y><F><C><S><Q><E><C><F><K><G><S><W><A><T><H><K><L><L><H><K><K><A><K><D><E><K><A><K><R><E><V><S><S><W><T><V><E><G><D><I><N><T><D><P><W><A><G><Y><R><Y><T><G><K><L><R><P><H><Y><P><L><M><P><T><R><P><V><P><S><Y><I><Q><R><P><D><Y><A><D><H><P><L><G><M><S><E><S><E><Q><A><L><K><G><T><S><Q><I><K><L><L><S><S><E><D><I><E><G><M><R><L><V><C><R><L><A><R><E><V><L><D><V><A><A><G><M><I><K><P><G><V><T><T><E><E><I><D><H><A><V><H><L><A><C><I><A><R><N><C><Y><P><S><P><L><N><Y><Y><N><F><P><K><S><C><C><T><S><V><N><E><V><I><C><H><G><I><P><D><R><R><P><L><Q><E><G><D><I><V><N><V><D><I><T><L><Y><R><N><G><Y><H><G><D><L><N><E><T><F><F><V><G><E><V><D><D><G><A><R><K><L><V><Q><T><T><Y><E><C><L><M><Q><A><I><D><A><V><K><P><G><V><R><Y><R><E><L><G><N><I><I><Q><K><H><A><Q><A><N><G><F><S><V><V><R><S><Y><C><G><H><G><I><H><K><L><F><H><T><A><P><N><V><P><H><Y><A><K><N><K><A><V><G><V><M><K><S><G><H><V><F><T><I><E><P><M><I><C><E><G><G><W><Q><D><E><T><W><P><D><G><W><T><A><V><T><R><D><G><K><R><S><A><Q><F><E><H><T><L><L><V><T><D><T><G><C><E><I><L><T><R><R><L><D><S><A><R><P><H><F><M><S><Q><F>
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.<BOP>
P53582
Q8NGK0
O51G2_HUMAN
Olfactory receptor OR11-28
Homo
<M><T><L><G><S><L><G><N><S><S><S><S><V><S><A><T><F><L><L><S><G><I><P><G><L><E><R><M><H><I><W><I><S><I><P><L><C><F><M><Y><L><V><S><I><P><G><N><C><T><I><L><F><I><I><K><T><E><R><S><L><H><E><P><M><Y><L><F><L><S><M><L><A><L><I><D><L><G><L><S><L><C><T><L><P><T><V><L><G><I><F><W><V><G><A><R><E><I><S><H><D><A><C><F><A><Q><L><F><F><I><H><C><F><S><F><L><E><S><S><V><L><L><S><M><A><F><D><R><F><V><A><I><C><H><P><L><H><Y><V><S><I><L><T><N><T><V><I><G><R><I><G><L><V><S><L><G><R><S><V><A><L><I><F><P><L><P><F><M><L><K><R><F><P><Y><C><G><S><P><V><L><S><H><S><Y><C><L><H><Q><E><V><M><K><L><A><C><A><D><M><K><A><N><S><I><Y><G><M><F><V><I><V><S><T><V><G><I><D><S><L><L><I><L><F><S><Y><A><L><I><L><R><T><V><L><S><I><A><S><R><A><E><R><F><K><A><L><N><T><C><V><S><H><I><C><A><V><L><L><F><Y><T><P><M><I><G><L><S><V><I><H><R><F><G><K><Q><A><P><H><L><V><Q><V><V><M><G><F><M><Y><L><L><F><P><P><V><M><N><P><I><V><Y><S><V><K><T><K><Q><I><R><D><R><V><T><H><A><F><C><Y>
Odorant receptor.<BOP>
Q8NGK0
Q06889
EGR3_HUMAN
Zinc finger protein pilot
Homo
<M><T><G><K><L><A><E><K><L><P><V><T><M><S><S><L><L><N><Q><L><P><D><N><L><Y><P><E><E><I><P><S><A><L><N><L><F><S><G><S><S><D><S><V><V><H><Y><N><Q><M><A><T><E><N><V><M><D><I><G><L><T><N><E><K><P><N><P><E><L><S><Y><S><G><S><F><Q><P><A><P><G><N><K><T><V><T><Y><L><G><K><F><A><F><D><S><P><S><N><W><C><Q><D><N><I><I><S><L><M><S><A><G><I><L><G><V><P><P><A><S><G><A><L><S><T><Q><T><S><T><A><S><M><V><Q><P><P><Q><G><D><V><E><A><M><Y><P><A><L><P><P><Y><S><N><C><G><D><L><Y><S><E><P><V><S><F><H><D><P><Q><G><N><P><G><L><A><Y><S><P><Q><D><Y><Q><S><A><K><P><A><L><D><S><N><L><F><P><M><I><P><D><Y><N><L><Y><H><H><P><N><D><M><G><S><I><P><E><H><K><P><F><Q><G><M><D><P><I><R><V><N><P><P><P><I><T><P><L><E><T><I><K><A><F><K><D><K><Q><I><H><P><G><F><G><S><L><P><Q><P><P><L><T><L><K><P><I><R><P><R><K><Y><P><N><R><P><S><K><T><P><L><H><E><R><P><H><A><C><P><A><E><G><C><D><R><R><F><S><R><S><D><E><L><T><R><H><L><R><I><H><T><G><H><K><P><F><Q><C><R><I><C><M><R><S><F><S><R><S><D><H><L><T><T><H><I><R><T><H><T><G><E><K><P><F><A><C><E><F><C><G><R><K><F><A><R><S><D><E><R><K><R><H><A><K><I><H><L><K><Q><K><E><K><K><A><E><K><G><G><A><P><S><A><S><S><A><P><P><V><S><L><A><P><V><V><T><T><C><A>
Probable transcription factor involved in muscle spindle development.<BOP>
Q06889
Q9H9P2
CHODL_HUMAN
Transmembrane protein MT75
Homo
<M><S><R><V><V><S><L><L><L><G><A><A><L><L><C><G><H><G><A><F><C><R><R><V><V><S><G><Q><K><V><C><F><A><D><F><K><H><P><C><Y><K><M><A><Y><F><H><E><L><S><S><R><V><S><F><Q><E><A><R><L><A><C><E><S><E><G><G><V><L><L><S><L><E><N><E><A><E><Q><K><L><I><E><S><M><L><Q><N><L><T><K><P><G><T><G><I><S><D><G><D><F><W><I><G><L><W><R><N><G><D><G><Q><T><S><G><A><C><P><D><L><Y><Q><W><S><D><G><S><N><S><Q><Y><R><N><W><Y><T><D><E><P><S><C><G><S><E><K><C><V><V><M><Y><H><Q><P><T><A><N><P><G><L><G><G><P><Y><L><Y><Q><W><N><D><D><R><C><N><M><K><H><N><Y><I><C><K><Y><E><P><E><I><N><P><T><A><P><V><E><K><P><Y><L><T><N><Q><P><G><D><T><H><Q><N><V><V><V><T><E><A><G><I><I><P><N><L><I><Y><V><V><I><P><T><I><P><L><L><L><L><I><L><V><A><F><G><T><C><C><F><Q><M><L><H><K><S><K><G><R><T><K><T><S><P><N><Q><S><T><L><W><I><S><K><S><T><R><K><E><S><G><M><E><V>
May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance.<BOP>
Q9H9P2
Q96KN2
CNDP1_HUMAN
Serum carnosinase
Homo
<M><D><P><K><L><G><R><M><A><A><S><L><L><A><V><L><L><L><L><L><E><R><G><M><F><S><S><P><S><P><P><P><A><L><L><E><K><V><F><Q><Y><I><D><L><H><Q><D><E><F><V><Q><T><L><K><E><W><V><A><I><E><S><D><S><V><Q><P><V><P><R><F><R><Q><E><L><F><R><M><M><A><V><A><A><D><T><L><Q><R><L><G><A><R><V><A><S><V><D><M><G><P><Q><Q><L><P><D><G><Q><S><L><P><I><P><P><V><I><L><A><E><L><G><S><D><P><T><K><G><T><V><C><F><Y><G><H><L><D><V><Q><P><A><D><R><G><D><G><W><L><T><D><P><Y><V><L><T><E><V><D><G><K><L><Y><G><R><G><A><T><D><N><K><G><P><V><L><A><W><I><N><A><V><S><A><F><R><A><L><E><Q><D><L><P><V><N><I><K><F><I><I><E><G><M><E><E><A><G><S><V><A><L><E><E><L><V><E><K><E><K><D><R><F><F><S><G><V><D><Y><I><V><I><S><D><N><L><W><I><S><Q><R><K><P><A><I><T><Y><G><T><R><G><N><S><Y><F><M><V><E><V><K><C><R><D><Q><D><F><H><S><G><T><F><G><G><I><L><H><E><P><M><A><D><L><V><A><L><L><G><S><L><V><D><S><S><G><H><I><L><V><P><G><I><Y><D><E><V><V><P><L><T><E><E><E><I><N><T><Y><K><A><I><H><L><D><L><E><E><Y><R><N><S><S><R><V><E><K><F><L><F><D><T><K><E><E><I><L><M><H><L><W><R><Y><P><S><L><S><I><H><G><I><E><G><A><F><D><E><P><G><T><K><T><V><I><P><G><R><V><I><G><K><F><S><I><R><L><V><P><H><M><N><V><S><A><V><E><K><Q><V><T><R><H><L><E><D><V><F><S><K><R><N><S><S><N><K><M><V><V><S><M><T><L><G><L><H><P><W><I><A><N><I><D><D><T><Q><Y><L><A><A><K><R><A><I><R><T><V><F><G><T><E><P><D><M><I><R><D><G><S><T><I><P><I><A><K><M><F><Q><E><I><V><H><K><S><V><V><L><I><P><L><G><A><V><D><D><G><E><H><S><Q><N><E><K><I><N><R><W><N><Y><I><E><G><T><K><L><F><A><A><F><F><L><E><M><A><Q><L><H>
Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine).<BOP>
Q96KN2
P28065
PSB9_HUMAN
Really interesting new gene 12 protein
Homo
<M><L><R><A><G><A><P><T><G><D><L><P><R><A><G><E><V><H><T><G><T><T><I><M><A><V><E><F><D><G><G><V><V><M><G><S><D><S><R><V><S><A><G><E><A><V><V><N><R><V><F><D><K><L><S><P><L><H><E><R><I><Y><C><A><L><S><G><S><A><A><D><A><Q><A><V><A><D><M><A><A><Y><Q><L><E><L><H><G><I><E><L><E><E><P><P><L><V><L><A><A><A><N><V><V><R><N><I><S><Y><K><Y><R><E><D><L><S><A><H><L><M><V><A><G><W><D><Q><R><E><G><G><Q><V><Y><G><T><L><G><G><M><L><T><R><Q><P><F><A><I><G><G><S><G><S><T><F><I><Y><G><Y><V><D><A><A><Y><K><P><G><M><S><P><E><E><C><R><R><F><T><T><D><A><I><A><L><A><M><S><R><D><G><S><S><G><G><V><I><Y><L><V><T><I><T><A><A><G><V><D><H><R><V><I><L><G><N><E><L><P><K><F><Y><D><E>
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.<BOP>
P28065
P04278
SHBG_HUMAN
Testosterone-estrogen-binding globulin
Homo
<M><E><S><R><G><P><L><A><T><S><R><L><L><L><L><L><L><L><L><L><L><R><H><T><R><Q><G><W><A><L><R><P><V><L><P><T><Q><S><A><H><D><P><P><A><V><H><L><S><N><G><P><G><Q><E><P><I><A><V><M><T><F><D><L><T><K><I><T><K><T><S><S><S><F><E><V><R><T><W><D><P><E><G><V><I><F><Y><G><D><T><N><P><K><D><D><W><F><M><L><G><L><R><D><G><R><P><E><I><Q><L><H><N><H><W><A><Q><L><T><V><G><A><G><P><R><L><D><D><G><R><W><H><Q><V><E><V><K><M><E><G><D><S><V><L><L><E><V><D><G><E><E><V><L><R><L><R><Q><V><S><G><P><L><T><S><K><R><H><P><I><M><R><I><A><L><G><G><L><L><F><P><A><S><N><L><R><L><P><L><V><P><A><L><D><G><C><L><R><R><D><S><W><L><D><K><Q><A><E><I><S><A><S><A><P><T><S><L><R><S><C><D><V><E><S><N><P><G><I><F><L><P><P><G><T><Q><A><E><F><N><L><R><D><I><P><Q><P><H><A><E><P><W><A><F><S><L><D><L><G><L><K><Q><A><A><G><S><G><H><L><L><A><L><G><T><P><E><N><P><S><W><L><S><L><H><L><Q><D><Q><K><V><V><L><S><S><G><S><G><P><G><L><D><L><P><L><V><L><G><L><P><L><Q><L><K><L><S><M><S><R><V><V><L><S><Q><G><S><K><M><K><A><L><A><L><P><P><L><G><L><A><P><L><L><N><L><W><A><K><P><Q><G><R><L><F><L><G><A><L><P><G><E><D><S><S><T><S><F><C><L><N><G><L><W><A><Q><G><Q><R><L><D><V><D><Q><A><L><N><R><S><H><E><I><W><T><H><S><C><P><Q><S><P><G><N><G><T><D><A><S><H>
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.<BOP>
P04278
A8MW99
MEI4_HUMAN
Meiosis-specific protein MEI4
Homo
<M><D><V><Q><K><W><Y><L><R><T><S><K><L><A><L><A><L><A><I><I><R><S><K><P><A><D><K><S><S><R><E><Y><T><E><H><L><A><M><L><L><S><E><E><Q><S><K><W><R><S><K><V><E><I><L><E><A><E><V><M><Q><L><R><Q><K><L><L><V><S><R><L><C><S><G><S><F><K><S><G><Y><V><S><S><Q><L><E><A><Q><E><P><K><S><S><E><S><T><L><T><S><M><E><D><S><G><C><D><L><S><N><E><Q><R><T><E><S><S><D><L><S><Q><H><F><V><E><S><C><T><P><T><H><F><P><P><L><P><L><V><K><R><P><C><A><I><L><Q><N><P><L><S><S><H><M><Q><F><L><Q><Y><L><L><E><L><K><N><L><T><E><S><G><N><L><K><R><D><L><T><H><F><E><K><D><S><S><T><V><S><D><S><V><F><Q><L><L><D><G><L><I><T><F><Y><R><N><P><K><L><P><F><S><R><F><W><T><E><A><V><G><T><L><A><S><L><I><S><D><Y><N><L><S><S><H><I><L><K><K><C><S><K><K><L><E><E><F><E><K><T><L><L><H><A><I><L><G><N><N><H><I><N><Q><F><Q><V><Q><H><Y><V><S><Q><S><L><V><T><L><G><N><C><S><L><L><R><K><S><I><I><S><L><L><L><S><E><V><N><G><F><A><D><D><L><G><A><I><N><Q><E><Q><A><S><Y><D><V><S><R><Y><E><N><I><F><Y><L><F><W><V><L><E><Q><L><L><Q><K><E><T><E><E><G><N><T><S><S><I><G><H><D><D><Q><E><I><K><K><F><L><Q><K><H><D><E><T><I><F><Q><L><S><D><A><F><P><L><F><T><F><Y><L><W><R><V><G><I><L><L><S><S><A><Q><I><E><T><L><R><K>
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.<BOP>
A8MW99
O95671
ASML_HUMAN
N-acetylserotonin O-methyltransferase-like protein
Homo
<M><V><L><C><P><V><I><G><K><L><L><H><K><R><V><V><L><A><S><A><S><P><R><R><Q><E><I><L><S><N><A><G><L><R><F><E><V><V><P><S><K><F><K><E><K><L><D><K><A><S><F><A><T><P><Y><G><Y><A><M><E><T><A><K><Q><K><A><L><E><V><A><N><R><L><Y><Q><K><D><L><R><A><P><D><V><V><I><G><A><D><T><I><V><T><V><G><G><L><I><L><E><K><P><V><D><K><Q><D><A><Y><R><M><L><S><R><L><S><G><R><E><H><S><V><F><T><G><V><A><I><V><H><C><S><S><K><D><H><Q><L><D><T><R><V><S><E><F><Y><E><E><T><K><V><K><F><S><E><L><S><E><E><L><L><W><E><Y><V><H><S><G><E><P><M><D><K><A><G><G><Y><G><I><Q><A><L><G><G><M><L><V><E><S><V><H><G><D><F><L><N><V><V><G><F><P><L><N><H><F><C><K><Q><L><V><K><L><Y><Y><P><P><R><P><E><D><L><R><R><S><V><K><H><D><S><I><P><A><A><D><T><F><E><D><L><S><D><V><E><G><G><G><S><E><P><T><Q><R><D><A><G><S><R><D><E><K><A><E><A><G><E><A><G><Q><A><T><A><E><A><E><C><H><R><T><R><E><T><L><P><P><F><P><T><R><L><L><E><L><I><E><G><F><M><L><S><K><G><L><L><T><A><C><K><L><K><V><F><D><L><L><K><D><E><A><P><Q><K><A><A><D><I><A><S><K><V><D><A><S><A><C><G><M><E><R><L><L><D><I><C><A><A><M><G><L><L><E><K><T><E><Q><G><Y><S><N><T><E><T><A><N><V><Y><L><A><S><D><G><E><Y><S><L><H><G><F><I><M><H><N><N><D><L><T><W><N><L><F><T><Y><L><E><F><A><I><R><E><G><T><N><Q><H><H><R><A><L><G><K><K><A><E><D><L><F><Q><D><A><Y><Y><Q><S><P><E><T><R><L><R><F><M><R><A><M><H><G><M><T><K><L><T><A><C><Q><V><A><T><A><F><N><L><S><R><F><S><S><A><C><D><V><G><G><C><T><G><A><L><A><R><E><L><A><R><E><Y><P><R><M><Q><V><T><V><F><D><L><P><D><I><I><E><L><A><A><H><F><Q><P><P><G><P><Q><A><V><Q><I><H><F><A><A><G><D><F><F><R><D><P><L><P><S><A><E><L><Y><V><L><C><R><I><L><H><D><W><P><D><D><K><V><H><K><L><L><S><R><V><A><E><S><C><K><P><G><A><G><L><L><L><V><E><T><L><L><D><E><E><K><R><V><A><Q><R><A><L><M><Q><S><L><N><M><L><V><Q><T><E><G><K><E><R><S><L><G><E><Y><Q><C><L><L><E><L><H><G><F><H><Q><V><Q><V><V><H><L><G><G><V><L><D><A><I><L><A><T><K><V><A><P>
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP . May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids . In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable).<BOP>
O95671
Q6XD76
ASCL4_HUMAN
Class A basic helix-loop-helix protein 44
Homo
<M><E><T><R><K><P><A><E><R><L><A><L><P><Y><S><L><R><T><A><P><L><G><V><P><G><T><L><P><G><L><P><R><R><D><P><L><R><V><A><L><R><L><D><A><A><C><W><E><W><A><R><S><G><C><A><R><G><W><Q><Y><L><P><V><P><L><D><S><A><F><E><P><A><F><L><R><K><R><N><E><R><E><R><Q><R><V><R><C><V><N><E><G><Y><A><R><L><R><D><H><L><P><R><E><L><A><D><K><R><L><S><K><V><E><T><L><R><A><A><I><D><Y><I><K><H><L><Q><E><L><L><E><R><Q><A><W><G><L><E><G><A><A><G><A><V><P><Q><R><R><A><E><C><N><S><D><G><E><S><K><A><S><S><A><P><S><P><S><S><E><P><E><E><G><G><S>
Could be a transcriptional regulator involved in skin development.<BOP>
Q6XD76
Q13155
AIMP2_HUMAN
Protein JTV-1
Homo
<M><P><M><Y><Q><V><K><P><Y><H><G><G><G><A><P><L><R><V><E><L><P><T><C><M><Y><R><L><P><N><V><H><G><R><S><Y><G><P><A><P><G><A><G><H><V><Q><E><E><S><N><L><S><L><Q><A><L><E><S><R><Q><D><D><I><L><K><R><L><Y><E><L><K><A><A><V><D><G><L><S><K><M><I><Q><T><P><D><A><D><L><D><V><T><N><I><I><Q><A><D><E><P><T><T><L><T><T><N><A><L><D><L><N><S><V><L><G><K><D><Y><G><A><L><K><D><I><V><I><N><A><N><P><A><S><P><P><L><S><L><L><V><L><H><R><L><L><C><E><H><F><R><V><L><S><T><V><H><T><H><S><S><V><K><S><V><P><E><N><L><L><K><C><F><G><E><Q><N><K><K><Q><P><R><Q><D><Y><Q><L><G><F><T><L><I><W><K><N><V><P><K><T><Q><M><K><F><S><I><Q><T><M><C><P><I><E><G><E><G><N><I><A><R><F><L><F><S><L><F><G><Q><K><H><N><A><V><N><A><T><L><I><D><S><W><V><D><I><A><I><F><Q><L><K><E><G><S><S><K><E><K><A><A><V><F><R><S><M><N><S><A><L><G><K><S><P><W><L><A><G><N><E><L><T><V><A><D><V><V><L><W><S><V><L><Q><Q><I><G><G><C><S><V><T><V><P><A><N><V><Q><R><W><M><R><S><C><E><N><L><A><P><F><N><T><A><L><K><L><L><K>
Required for assembly and stability of the aminoacyl-tRNA synthase complex . Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.<BOP>
Q13155
Q8NEM2
SHCBP_HUMAN
SHC SH2 domain-binding protein 1
Homo
<M><A><D><G><S><L><T><G><G><G><L><E><A><A><A><M><A><P><E><R><M><G><W><A><V><E><Q><E><L><A><S><L><E><K><G><L><F><Q><D><E><D><S><C><S><D><C><S><Y><R><D><K><P><G><S><S><L><Q><S><F><M><P><E><G><K><T><F><F><P><E><I><F><Q><T><N><Q><L><L><F><Y><E><R><F><R><A><Y><Q><D><Y><I><L><A><D><C><K><A><S><E><V><Q><E><F><T><A><E><F><L><E><K><V><L><E><P><S><G><W><R><A><V><W><H><T><N><V><F><K><V><L><V><E><I><T><D><V><D><F><A><A><L><K><A><V><V><R><L><A><E><P><Y><L><C><D><S><Q><V><S><T><F><T><M><E><C><M><K><E><L><L><D><L><K><E><H><R><L><P><L><Q><E><L><W><V><V><F><D><D><S><G><V><F><D><Q><T><A><L><A><I><E><H><V><R><F><F><Y><Q><N><I><W><R><S><W><D><E><E><E><E><D><E><Y><D><Y><F><V><R><C><V><E><P><R><L><R><L><H><Y><D><I><L><E><D><R><V><P><S><G><L><I><V><D><Y><H><N><L><L><S><Q><C><E><E><S><Y><R><K><F><L><N><L><R><S><S><L><S><N><C><N><S><D><S><E><Q><E><N><I><S><M><V><E><G><L><K><L><Y><S><E><M><E><Q><L><K><Q><K><L><K><L><I><E><N><P><L><L><R><Y><V><F><G><Y><Q><K><N><S><N><I><Q><A><K><G><V><R><S><S><G><Q><K><I><T><H><V><V><S><S><T><M><M><A><G><L><L><R><S><L><L><T><D><R><L><C><Q><E><P><G><E><E><E><R><E><I><Q><F><H><S><D><P><L><S><A><I><N><A><C><F><E><G><D><T><V><I><V><C><P><G><H><Y><V><V><H><G><T><F><S><I><A><D><S><I><E><L><E><G><Y><G><L><P><D><D><I><V><I><E><K><R><G><K><G><D><T><F><V><D><C><T><G><A><D><I><K><I><S><G><I><K><F><V><Q><H><D><A><V><E><G><I><L><I><V><H><R><G><K><T><T><L><E><N><C><V><L><Q><C><E><T><T><G><V><T><V><R><T><S><A><E><F><L><M><K><N><S><D><L><Y><G><A><K><G><A><G><I><E><I><Y><P><G><S><Q><C><T><L><S><D><N><G><I><H><H><C><K><E><G><I><L><I><K><D><F><L><D><E><H><Y><D><I><P><K><I><S><M><V><N><N><I><I><H><N><N><E><G><Y><G><V><V><L><V><K><P><T><I><F><S><D><L><Q><E><N><A><E><D><G><T><E><E><N><K><A><L><K><I><Q><T><S><G><E><P><D><V><A><E><R><V><D><L><E><E><L><I><E><C><A><T><G><K><M><E><L><C><A><R><T><D><P><S><E><Q><V><E><G><N><C><E><I><V><N><E><L><I><A><A><S><T><Q><K><G><Q><I><K><K><K><R><L><S><E><L><G><I><T><Q><A><D><D><N><L><M><S><Q><E><M><F><V><G><I><V><G><N><Q><F><K><W><N><G><K><G><S><F><G><T><F><L><F>
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.<BOP>
Q8NEM2
Q9UQQ2
SH2B3_HUMAN
Signal transduction protein Lnk
Homo
<M><N><G><P><A><L><Q><P><S><S><P><S><S><A><P><S><A><S><P><A><A><A><P><R><G><W><S><E><F><C><E><L><H><A><V><A><A><A><R><E><L><A><R><Q><Y><W><L><F><A><R><E><H><P><Q><H><A><P><L><R><A><E><L><V><S><L><Q><F><T><D><L><F><Q><R><Y><F><C><R><E><V><R><D><G><R><A><P><G><R><D><Y><R><D><T><G><R><G><P><P><A><K><A><E><A><S><P><E><P><G><P><G><P><A><A><P><G><L><P><K><A><R><S><S><E><E><L><A><P><P><R><P><P><G><P><C><S><F><Q><H><F><R><R><S><L><R><H><I><F><R><R><R><S><A><G><E><L><P><A><A><H><T><A><A><A><P><G><T><P><G><E><A><A><E><T><P><A><R><P><G><L><A><K><K><F><L><P><W><S><L><A><R><E><P><P><P><E><A><L><K><E><A><V><L><R><Y><S><L><A><D><E><A><S><M><D><S><G><A><R><W><Q><R><G><R><L><A><L><R><R><A><P><G><P><D><G><P><D><R><V><L><E><L><F><D><P><P><K><S><S><R><P><K><L><Q><A><A><C><S><S><I><Q><E><V><R><W><C><T><R><L><E><M><P><D><N><L><Y><T><F><V><L><K><V><K><D><R><T><D><I><I><F><E><V><G><D><E><Q><Q><L><N><S><W><M><A><E><L><S><E><C><T><G><R><G><L><E><S><T><E><A><E><M><H><I><P><S><A><L><E><P><S><T><S><S><S><P><R><G><S><T><D><S><L><N><Q><G><A><S><P><G><G><L><L><D><P><A><C><Q><K><T><D><H><F><L><S><C><Y><P><W><F><H><G><P><I><S><R><V><K><A><A><Q><L><V><Q><L><Q><G><P><D><A><H><G><V><F><L><V><R><Q><S><E><T><R><R><G><E><Y><V><L><T><F><N><F><Q><G><I><A><K><H><L><R><L><S><L><T><E><R><G><Q><C><R><V><Q><H><L><H><F><P><S><V><V><D><M><L><H><H><F><Q><R><S><P><I><P><L><E><C><G><A><A><C><D><V><R><L><S><S><Y><V><V><V><V><S><Q><P><P><G><S><C><N><T><V><L><F><P><F><S><L><P><H><W><D><S><E><S><L><P><H><W><G><S><E><L><G><L><P><H><L><S><S><S><G><C><P><R><G><L><S><P><E><G><L><P><G><R><S><S><P><P><E><Q><I><F><H><L><V><P><S><P><E><E><L><A><N><S><L><Q><H><L><E><H><E><P><V><N><R><A><R><D><S><D><Y><E><M><D><S><S><S><R><S><H><L><R><A><I><D><N><Q><Y><T><P><L>
Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.<BOP>
Q9UQQ2
Q07444
NKG2E_HUMAN
NKG2-E-activating NK receptor
Homo
<M><S><K><Q><R><G><T><F><S><E><V><S><L><A><Q><D><P><K><W><Q><Q><R><K><P><K><G><N><K><S><S><I><S><G><T><E><Q><E><I><F><Q><V><E><L><N><L><Q><N><A><S><L><N><H><Q><G><I><D><K><I><Y><D><C><Q><G><L><L><P><P><P><E><K><L><T><A><E><V><L><G><I><I><C><I><V><L><M><A><T><V><L><K><T><I><V><L><I><P><F><L><E><Q><N><N><S><S><P><N><A><R><T><Q><K><A><R><H><C><G><H><C><P><E><E><W><I><T><Y><S><N><S><C><Y><Y><I><G><K><E><R><R><T><W><E><E><S><L><Q><A><C><A><S><K><N><S><S><S><L><L><C><I><D><N><E><E><E><M><K><F><L><A><S><I><L><P><S><S><W><I><G><V><F><R><N><S><S><H><H><P><W><V><T><I><N><G><L><A><F><K><H><E><I><K><D><S><D><H><A><E><R><N><C><A><M><L><H><V><R><G><L><I><S><D><Q><C><G><S><S><R><I><I><R><R><G><F><I><M><L><T><R><L><V><L><N><S>
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.<BOP>
Q07444
Q9Y5P0
O51B4_HUMAN
Odorant receptor HOR5'beta1
Homo
<M><W><Y><N><N><S><A><G><P><F><L><L><T><G><F><L><G><S><E><A><V><H><Y><R><I><S><M><S><F><F><V><I><Y><F><S><V><L><F><G><N><G><T><L><L><V><L><I><W><N><D><H><S><L><H><E><P><M><Y><Y><F><L><A><M><L><A><D><T><D><L><G><M><T><F><T><T><M><P><T><V><L><G><V><L><L><L><D><Q><R><E><I><A><H><A><A><C><F><T><Q><S><F><I><H><S><L><A><I><V><E><S><G><I><L><L><V><L><A><Y><D><C><F><I><A><I><R><T><P><L><R><Y><N><C><I><L><T><N><S><R><V><M><N><I><G><L><G><V><L><M><R><G><F><M><S><I><L><P><I><I><L><S><L><Y><C><Y><P><Y><C><G><S><R><A><L><L><H><T><F><C><L><H><Q><D><V><I><K><L><A><C><A><D><I><T><F><N><H><I><Y><P><I><I><Q><T><S><L><T><V><F><L><D><A><L><I><I><I><F><S><Y><I><L><I><L><K><T><V><M><G><I><A><S><G><Q><E><E><A><K><S><L><N><T><C><V><S><H><I><S><C><V><L><V><F><H><I><T><V><M><G><L><S><F><I><H><R><F><G><K><H><A><P><H><V><V><P><I><T><M><S><Y><V><H><F><L><F><P><P><F><V><N><P><I><I><Y><S><I><K><T><K><Q><I><Q><R><S><I><I><R><L><F><S><G><Q><S><R><A>
Odorant receptor.<BOP>
Q9Y5P0
A0A0A6YYG2
TVB66_HUMAN
T cell receptor beta variable 6-6
Homo
<M><S><I><S><L><L><C><C><A><A><F><P><L><L><W><A><G><P><V><N><A><G><V><T><Q><T><P><K><F><R><I><L><K><I><G><Q><S><M><T><L><Q><C><A><Q><D><M><N><H><N><Y><M><Y><W><Y><R><Q><D><P><G><M><G><L><K><L><I><Y><Y><S><V><G><A><G><I><T><D><K><G><E><V><P><N><G><Y><N><V><S><R><S><T><T><E><D><F><P><L><R><L><E><L><A><A><P><S><Q><T><S><V><Y><F><C><A><S><S><Y>
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0A6YYG2
Q9BSD3
RHNO1_HUMAN
RAD9, RAD1, HUS1-interacting nuclear orphan protein
Homo
<M><P><P><R><K><K><R><R><Q><P><S><Q><K><A><P><L><L><F><H><Q><Q><P><L><E><G><P><K><H><S><C><A><S><T><Q><L><P><I><T><H><T><R><Q><V><P><S><K><P><I><D><H><S><T><I><T><S><W><V><S><P><D><F><D><T><A><A><G><S><L><F><P><A><Y><Q><K><H><Q><N><R><A><R><H><S><S><R><K><P><T><T><S><K><F><P><H><L><T><F><E><S><P><Q><S><S><S><S><E><T><L><G><I><P><L><I><R><E><C><P><S><E><S><E><K><D><V><S><R><R><P><L><V><P><V><L><S><P><Q><S><C><G><N><M><S><V><Q><A><L><Q><S><L><P><Y><V><F><I><P><P><D><I><Q><T><P><E><S><S><S><V><K><E><E><L><I><P><Q><D><Q><K><E><N><S><L><L><S><C><T><L><H><T><G><T><P><N><S><P><E><P><G><P><V><L><V><K><D><T><P><E><D><K><Y><G><I><K><V><T><W><R><R><R><Q><H><L><L><A><Y><L><R><E><R><G><K><L><S><R><S><Q><F><L><V><K><S>
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.<BOP>
Q9BSD3
Q9H2A3
NGN2_HUMAN
Protein atonal homolog 4
Homo
<M><F><V><K><S><E><T><L><E><L><K><E><E><E><D><V><L><V><L><L><G><S><A><S><P><A><L><A><A><L><T><P><L><S><S><S><A><D><E><E><E><E><E><E><P><G><A><S><G><G><A><R><R><Q><R><G><A><E><A><G><Q><G><A><R><G><G><V><A><A><G><A><E><G><C><R><P><A><R><L><L><G><L><V><H><D><C><K><R><R><P><S><R><A><R><A><V><S><R><G><A><K><T><A><E><T><V><Q><R><I><K><K><T><R><R><L><K><A><N><N><R><E><R><N><R><M><H><N><L><N><A><A><L><D><A><L><R><E><V><L><P><T><F><P><E><D><A><K><L><T><K><I><E><T><L><R><F><A><H><N><Y><I><W><A><L><T><E><T><L><R><L><A><D><H><C><G><G><G><G><G><G><L><P><G><A><L><F><S><E><A><V><L><L><S><P><G><G><A><S><A><A><L><S><S><S><G><D><S><P><S><P><A><S><T><W><S><C><T><N><S><P><A><P><S><S><S><V><S><S><N><S><T><S><P><Y><S><C><T><L><S><P><A><S><P><A><G><S><D><M><D><Y><W><Q><P><P><P><P><D><K><H><R><Y><A><P><H><L><P><I><A><R><D><C><I>
Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').<BOP>
Q9H2A3
Q5VZF2
MBNL2_HUMAN
Muscleblind-like protein-like 39
Homo
<M><A><L><N><V><A><P><V><R><D><T><K><W><L><T><L><E><V><C><R><Q><F><Q><R><G><T><C><S><R><S><D><E><E><C><K><F><A><H><P><P><K><S><C><Q><V><E><N><G><R><V><I><A><C><F><D><S><L><K><G><R><C><S><R><E><N><C><K><Y><L><H><P><P><T><H><L><K><T><Q><L><E><I><N><G><R><N><N><L><I><Q><Q><K><T><A><A><A><M><L><A><Q><Q><M><Q><F><M><F><P><G><T><P><L><H><P><V><P><T><F><P><V><G><P><A><I><G><T><N><T><A><I><S><F><A><P><Y><L><A><P><V><T><P><G><V><G><L><V><P><T><E><I><L><P><T><T><P><V><I><V><P><G><S><P><P><V><T><V><P><G><S><T><A><T><Q><K><L><L><R><T><D><K><L><E><V><C><R><E><F><Q><R><G><N><C><A><R><G><E><T><D><C><R><F><A><H><P><A><D><S><T><M><I><D><T><S><D><N><T><V><T><V><C><M><D><Y><I><K><G><R><C><M><R><E><K><C><K><Y><F><H><P><P><A><H><L><Q><A><K><I><K><A><A><Q><H><Q><A><N><Q><A><A><V><A><A><Q><A><A><A><A><A><A><T><V><M><A><F><P><P><G><A><L><H><P><L><P><K><R><Q><A><L><E><K><S><N><G><T><S><A><V><F><N><P><S><V><L><H><Y><Q><Q><A><L><T><S><A><Q><L><Q><Q><H><A><A><F><I><P><T><G><S><V><L><C><M><T><P><A><T><S><I><D><N><S><E><I><I><S><R><N><G><M><E><C><Q><E><S><A><L><R><I><T><K><H><C><Y><C><T><Y><Y><P><V><S><S><S><I><E><L><P><Q><T><A><C>
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).<BOP>
Q5VZF2
O75354
ENTP6_HUMAN
CD39 antigen-like 2
Homo
<M><K><K><G><I><R><Y><E><T><S><R><K><T><S><Y><I><F><Q><Q><P><Q><H><G><P><W><Q><T><R><M><R><K><I><S><N><H><G><S><L><R><V><A><K><V><A><Y><P><L><G><L><C><V><G><V><F><I><Y><V><A><Y><I><K><W><H><R><A><T><A><T><Q><A><F><F><S><I><T><R><A><A><P><G><A><R><W><G><Q><Q><A><H><S><P><L><G><T><A><A><D><G><H><E><V><F><Y><G><I><M><F><D><A><G><S><T><G><T><R><V><H><V><F><Q><F><T><R><P><P><R><E><T><P><T><L><T><H><E><T><F><K><A><L><K><P><G><L><S><A><Y><A><D><D><V><E><K><S><A><Q><G><I><R><E><L><L><D><V><A><K><Q><D><I><P><F><D><F><W><K><A><T><P><L><V><L><K><A><T><A><G><L><R><L><L><P><G><E><K><A><Q><K><L><L><Q><K><V><K><K><V><F><K><A><S><P><F><L><V><G><D><D><C><V><S><I><M><N><G><T><D><E><G><V><S><A><W><I><T><I><N><F><L><T><G><S><L><K><T><P><G><G><S><S><V><G><M><L><D><L><G><G><G><S><T><Q><I><A><F><L><P><R><V><E><G><T><L><Q><A><S><P><P><G><Y><L><T><A><L><R><M><F><N><R><T><Y><K><L><Y><S><Y><S><Y><L><G><L><G><L><M><S><A><R><L><A><I><L><G><G><V><E><G><Q><P><A><K><D><G><K><E><L><V><S><P><C><L><S><P><S><F><K><G><E><W><E><H><A><E><V><T><Y><R><V><S><G><Q><K><A><A><A><S><L><H><E><L><C><A><A><R><V><S><E><V><L><Q><N><R><V><H><R><T><E><E><V><K><H><V><D><F><Y><A><F><S><Y><Y><Y><D><L><A><A><G><V><G><L><I><D><A><E><K><G><G><S><L><V><V><G><D><F><E><I><A><A><K><Y><V><C><R><T><L><E><T><Q><P><Q><S><S><P><F><S><C><M><D><L><T><Y><V><S><L><L><L><Q><E><F><G><F><P><R><S><K><V><L><K><L><T><R><K><I><D><N><V><E><T><S><W><A><L><G><A><I><F><H><Y><I><D><S><L><N><R><Q><K><S><P><A><S>
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP . The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides .<BOP>
O75354
P22466
GALA_HUMAN
Galanin message-associated peptide
Homo
<M><A><R><G><S><A><L><L><L><A><S><L><L><L><A><A><A><L><S><A><S><A><G><L><W><S><P><A><K><E><K><R><G><W><T><L><N><S><A><G><Y><L><L><G><P><H><A><V><G><N><H><R><S><F><S><D><K><N><G><L><T><S><K><R><E><L><R><P><E><D><D><M><K><P><G><S><F><D><R><S><I><P><E><N><N><I><M><R><T><I><I><E><F><L><S><F><L><H><L><K><E><A><G><A><L><D><R><L><L><D><L><P><A><A><A><S><S><E><D><I><E><R><S>
Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.<BOP>
P22466
P08574
CY1_HUMAN
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Homo
<M><A><A><A><A><A><S><L><R><G><V><V><L><G><P><R><G><A><G><L><P><G><A><R><A><R><G><L><L><C><S><A><R><P><G><Q><L><P><L><R><T><P><Q><A><V><A><L><S><S><K><S><G><L><S><R><G><R><K><V><M><L><S><A><L><G><M><L><A><A><G><G><A><G><L><A><M><A><L><H><S><A><V><S><A><S><D><L><E><L><H><P><P><S><Y><P><W><S><H><R><G><L><L><S><S><L><D><H><T><S><I><R><R><G><F><Q><V><Y><K><Q><V><C><A><S><C><H><S><M><D><F><V><A><Y><R><H><L><V><G><V><C><Y><T><E><D><E><A><K><E><L><A><A><E><V><E><V><Q><D><G><P><N><E><D><G><E><M><F><M><R><P><G><K><L><F><D><Y><F><P><K><P><Y><P><N><S><E><A><A><R><A><A><N><N><G><A><L><P><P><D><L><S><Y><I><V><R><A><R><H><G><G><E><D><Y><V><F><S><L><L><T><G><Y><C><E><P><P><T><G><V><S><L><R><E><G><L><Y><F><N><P><Y><F><P><G><Q><A><I><A><M><A><P><P><I><Y><T><D><V><L><E><F><D><D><G><T><P><A><T><M><S><Q><I><A><K><D><V><C><T><F><L><R><W><A><S><E><P><E><H><D><H><R><K><R><M><G><L><K><M><L><M><M><M><A><L><L><V><P><L><V><Y><T><I><K><R><H><K><W><S><V><L><K><S><R><K><L><A><Y><R><P><P><K>
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type h
P08574
P34096
RNAS4_HUMAN
Ribonuclease 4
Homo
<M><A><L><Q><R><T><H><S><L><L><L><L><L><L><L><T><L><L><G><L><G><L><V><Q><P><S><Y><G><Q><D><G><M><Y><Q><R><F><L><R><Q><H><V><H><P><E><E><T><G><G><S><D><R><Y><C><N><L><M><M><Q><R><R><K><M><T><L><Y><H><C><K><R><F><N><T><F><I><H><E><D><I><W><N><I><R><S><I><C><S><T><T><N><I><Q><C><K><N><G><K><M><N><C><H><E><G><V><V><K><V><T><D><C><R><D><T><G><S><S><R><A><P><N><C><R><Y><R><A><I><A><S><T><R><R><V><V><I><A><C><E><G><N><P><Q><V><P><V><H><F><D><G>
This RNase has marked specificity towards the 3' side of uridine nucleotides.<BOP>
P34096
Q96A05
VATE2_HUMAN
Vacuolar proton pump subunit E 2
Homo
<M><A><L><S><D><V><D><V><K><K><Q><I><K><H><M><M><A><F><I><E><Q><E><A><N><E><K><A><E><E><I><D><A><K><A><E><E><E><F><N><I><E><K><G><R><L><V><Q><T><Q><R><L><K><I><M><E><Y><Y><E><K><K><E><K><Q><I><E><Q><Q><K><K><I><L><M><S><T><M><R><N><Q><A><R><L><K><V><L><R><A><R><N><D><L><I><S><D><L><L><S><E><A><K><L><R><L><S><R><I><V><E><D><P><E><V><Y><Q><G><L><L><D><K><L><V><L><Q><G><L><L><R><L><L><E><P><V><M><I><V><R><C><R><P><Q><D><L><L><L><V><E><A><A><V><Q><K><A><I><P><E><Y><M><T><I><S><Q><K><H><V><E><V><Q><I><D><K><E><A><Y><L><A><V><N><A><A><G><G><V><E><V><Y><S><G><N><Q><R><I><K><V><S><N><T><L><E><S><R><L><D><L><S><A><K><Q><K><M><P><E><I><R><M><A><L><F><G><A><N><T><N><R><K><F><F><I>
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.<BOP>
Q96A05
Q96EU7
C1GLC_HUMAN
Core 1 beta3-galactosyltransferase-specific molecular chaperone
Homo
<M><L><S><E><S><S><S><F><L><K><G><V><M><L><G><S><I><F><C><A><L><I><T><M><L><G><H><I><R><I><G><H><G><N><R><M><H><H><H><E><H><H><H><L><Q><A><P><N><K><E><D><I><L><K><I><S><E><D><E><R><M><E><L><S><K><S><F><R><V><Y><C><I><I><L><V><K><P><K><D><V><S><L><W><A><A><V><K><E><T><W><T><K><H><C><D><K><A><E><F><F><S><S><E><N><V><K><V><F><E><S><I><N><M><D><T><N><D><M><W><L><M><M><R><K><A><Y><K><Y><A><F><D><K><Y><R><D><Q><Y><N><W><F><F><L><A><R><P><T><T><F><A><I><I><E><N><L><K><Y><F><L><L><K><K><D><P><S><Q><P><F><Y><L><G><H><T><I><K><S><G><D><L><E><Y><V><G><M><E><G><G><I><V><L><S><V><E><S><M><K><R><L><N><S><L><L><N><I><P><E><K><C><P><E><Q><G><G><M><I><W><K><I><S><E><D><K><Q><L><A><V><C><L><K><Y><A><G><V><F><A><E><N><A><E><D><A><D><G><K><D><V><F><N><T><K><S><V><G><L><S><I><K><E><A><M><T><Y><H><P><N><Q><V><V><E><G><C><C><S><D><M><A><V><T><F><N><G><L><T><P><N><Q><M><H><V><M><M><Y><G><V><Y><R><L><R><A><F><G><H><I><F><N><D><A><L><V><F><L><P><P><N><G><S><D><N><D>
Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).<BOP>
Q96EU7
Q92791
SC65_HUMAN
Synaptonemal complex protein SC65
Homo
<M><A><R><V><A><W><G><L><L><W><L><L><L><G><S><A><G><A><Q><Y><E><K><Y><S><F><R><G><F><P><P><E><D><L><M><P><L><A><A><A><Y><G><H><A><L><E><Q><Y><E><G><E><S><W><R><E><S><A><R><Y><L><E><A><A><L><R><L><H><R><L><L><R><D><S><E><A><F><C><H><A><N><C><S><G><P><A><P><A><A><K><P><D><P><D><G><G><R><A><D><E><W><A><C><E><L><R><L><F><G><R><V><L><E><R><A><A><C><L><R><R><C><K><R><T><L><P><A><F><Q><V><P><Y><P><P><R><Q><L><L><R><D><F><Q><S><R><L><P><Y><Q><Y><L><H><Y><A><L><F><K><A><N><R><L><E><K><A><V><A><A><A><Y><T><F><L><Q><R><N><P><K><H><E><L><T><A><K><Y><L><N><Y><Y><Q><G><M><L><D><V><A><D><E><S><L><T><D><L><E><A><Q><P><Y><E><A><V><F><L><R><A><V><K><L><Y><N><S><G><D><F><R><S><S><T><E><D><M><E><R><A><L><S><E><Y><L><A><V><F><A><R><C><L><A><G><C><E><G><A><H><E><Q><V><D><F><K><D><F><Y><P><A><I><A><D><L><F><A><E><S><L><Q><C><K><V><D><C><E><A><N><L><T><P><N><V><G><G><Y><F><V><D><K><F><V><A><T><M><Y><H><Y><L><Q><F><A><Y><Y><K><L><N><D><V><R><Q><A><A><R><S><A><A><S><Y><M><L><F><D><P><K><D><S><V><M><Q><Q><N><L><V><Y><Y><R><F><H><R><A><R><W><G><L><E><E><E><D><F><Q><P><R><E><E><A><M><L><Y><H><N><Q><T><A><E><L><R><E><L><L><E><F><T><H><M><Y><L><Q><S><D><D><E><M><E><L><E><E><T><E><P><P><L><E><P><E><D><A><L><S><D><A><E><F><E><G><E><G><D><Y><E><E><G><M><Y><A><D><W><W><Q><E><P><D><A><K><G><D><E><A><E><A><E><P><E><P><E><L><A>
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.<BOP>
Q92791
P00746
CFAD_HUMAN
Properdin factor D
Homo
<M><H><S><W><E><R><L><A><V><L><V><L><L><G><A><A><A><C><A><A><P><P><R><G><R><I><L><G><G><R><E><A><E><A><H><A><R><P><Y><M><A><S><V><Q><L><N><G><A><H><L><C><G><G><V><L><V><A><E><Q><W><V><L><S><A><A><H><C><L><E><D><A><A><D><G><K><V><Q><V><L><L><G><A><H><S><L><S><Q><P><E><P><S><K><R><L><Y><D><V><L><R><A><V><P><H><P><D><S><Q><P><D><T><I><D><H><D><L><L><L><L><Q><L><S><E><K><A><T><L><G><P><A><V><R><P><L><P><W><Q><R><V><D><R><D><V><A><P><G><T><L><C><D><V><A><G><W><G><I><V><N><H><A><G><R><R><P><D><S><L><Q><H><V><L><L><P><V><L><D><R><A><T><C><N><R><R><T><H><H><D><G><A><I><T><E><R><L><M><C><A><E><S><N><R><R><D><S><C><K><G><D><S><G><G><P><L><V><C><G><G><V><L><E><G><V><V><T><S><G><S><R><V><C><G><N><R><K><K><P><G><I><Y><T><R><V><A><S><Y><A><A><W><I><D><S><V><L><A>
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.<BOP>
P00746
P49842
STK19_HUMAN
Protein RP1
Homo
<M><Q><K><W><F><S><A><F><D><D><A><I><I><Q><R><Q><W><R><A><N><P><S><R><G><G><G><G><V><S><F><T><K><E><V><D><T><N><V><A><T><G><A><P><P><R><R><Q><R><V><P><G><R><A><C><P><W><R><E><P><I><R><G><R><R><G><A><R><P><G><G><G><D><A><G><G><T><P><G><E><T><V><R><H><C><S><A><P><E><D><P><I><F><R><F><S><S><L><H><S><Y><P><F><P><G><T><I><K><S><R><D><M><S><W><K><R><H><H><L><I><P><E><T><F><G><V><K><R><R><R><K><R><G><P><V><E><S><D><P><L><R><G><E><P><G><S><A><R><A><A><V><S><E><L><M><Q><L><F><P><R><G><L><F><E><D><A><L><P><P><I><V><L><R><S><Q><V><Y><S><L><V><P><D><R><T><V><A><D><R><Q><L><K><E><L><Q><E><Q><G><E><I><R><I><V><Q><L><G><F><D><L><D><A><H><G><I><I><F><T><E><D><Y><R><T><R><V><C><D><C><V><L><K><A><C><D><G><R><P><Y><A><G><A><V><Q><K><F><L><A><S><V><L><P><A><C><G><D><L><S><F><Q><Q><D><Q><M><T><Q><T><F><G><F><R><D><S><E><I><T><H><L><V><N><A><G><V><L><T><V><R><D><A><G><S><W><W><L><A><V><P><G><A><G><R><F><I><K><Y><F><V><K><G><R><Q><A><V><L><S><M><V><R><K><A><K><Y><R><E><L><L><L><S><E><L><L><G><R><R><A><P><V><V><V><R><L><G><L><T><Y><H><V><H><D><L><I><G><A><Q><L><V><D><C><I><S><T><T><S><G><T><L><L><R><L><P><E><T>
Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors.<BOP>
P49842
P30989
NTR1_HUMAN
NTRH
Homo
<M><R><L><N><S><S><A><P><G><T><P><G><T><P><A><A><D><P><F><Q><R><A><Q><A><G><L><E><E><A><L><L><A><P><G><F><G><N><A><S><G><N><A><S><E><R><V><L><A><A><P><S><S><E><L><D><V><N><T><D><I><Y><S><K><V><L><V><T><A><V><Y><L><A><L><F><V><V><G><T><V><G><N><T><V><T><A><F><T><L><A><R><K><K><S><L><Q><S><L><Q><S><T><V><H><Y><H><L><G><S><L><A><L><S><D><L><L><T><L><L><L><A><M><P><V><E><L><Y><N><F><I><W><V><H><H><P><W><A><F><G><D><A><G><C><R><G><Y><Y><F><L><R><D><A><C><T><Y><A><T><A><L><N><V><A><S><L><S><V><E><R><Y><L><A><I><C><H><P><F><K><A><K><T><L><M><S><R><S><R><T><K><K><F><I><S><A><I><W><L><A><S><A><L><L><A><V><P><M><L><F><T><M><G><E><Q><N><R><S><A><D><G><Q><H><A><G><G><L><V><C><T><P><T><I><H><T><A><T><V><K><V><V><I><Q><V><N><T><F><M><S><F><I><F><P><M><V><V><I><S><V><L><N><T><I><I><A><N><K><L><T><V><M><V><R><Q><A><A><E><Q><G><Q><V><C><T><V><G><G><E><H><S><T><F><S><M><A><I><E><P><G><R><V><Q><A><L><R><H><G><V><R><V><L><R><A><V><V><I><A><F><V><V><C><W><L><P><Y><H><V><R><R><L><M><F><C><Y><I><S><D><E><Q><W><T><P><F><L><Y><D><F><Y><H><Y><F><Y><M><V><T><N><A><L><F><Y><V><S><S><T><I><N><P><I><L><Y><N><L><V><S><A><N><F><R><H><I><F><L><A><T><L><A><C><L><C><P><V><W><R><R><R><R><K><R><P><A><F><S><R><K><A><D><S><V><S><S><N><H><T><L><S><S><N><A><T><R><E><T><L><Y>
G-protein coupled receptor for the tridecapeptide neurotensin (NTS) . Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis .<BOP>
P30989
Q2M3T9
HYAL4_HUMAN
Hyaluronoglucosaminidase-4
Homo
<M><K><V><L><S><E><G><Q><L><K><L><C><V><V><Q><P><V><H><L><T><S><W><L><L><I><F><F><I><L><K><S><I><S><C><L><K><P><A><R><L><P><I><Y><Q><R><K><P><F><I><A><A><W><N><A><P><T><D><Q><C><L><I><K><Y><N><L><R><L><N><L><K><M><F><P><V><I><G><S><P><L><A><K><A><R><G><Q><N><V><T><I><F><Y><V><N><R><L><G><Y><Y><P><W><Y><T><S><Q><G><V><P><I><N><G><G><L><P><Q><N><I><S><L><Q><V><H><L><E><K><A><D><Q><D><I><N><Y><Y><I><P><A><E><D><F><S><G><L><A><V><I><D><W><E><Y><W><R><P><Q><W><A><R><N><W><N><S><K><D><V><Y><R><Q><K><S><R><K><L><I><S><D><M><G><K><N><V><S><A><T><D><I><E><Y><L><A><K><V><T><F><E><E><S><A><K><A><F><M><K><E><T><I><K><L><G><I><K><S><R><P><K><G><L><W><G><Y><Y><L><Y><P><D><C><H><N><Y><N><V><Y><A><P><N><Y><S><G><S><C><P><E><D><E><V><L><R><N><N><E><L><S><W><L><W><N><S><S><A><A><L><Y><P><S><I><G><V><W><K><S><L><G><D><S><E><N><I><L><R><F><S><K><F><R><V><H><E><S><M><R><I><S><T><M><T><S><H><D><Y><A><L><P><V><F><V><Y><T><R><L><G><Y><R><D><E><P><L><F><F><L><S><K><Q><D><L><V><S><T><I><G><E><S><A><A><L><G><A><A><G><I><V><I><W><G><D><M><N><L><T><A><S><K><A><N><C><T><K><V><K><Q><F><V><S><S><D><L><G><S><Y><I><A><N><V><T><R><A><A><E><V><C><S><L><H><L><C><R><N><N><G><R><C><I><R><K><M><W><N><A><P><S><Y><L><H><L><N><P><A><S><Y><H><I><E><A><S><E><D><G><E><F><T><V><K><G><K><A><S><D><T><D><L><A><V><M><A><D><T><F><S><C><H><C><Y><Q><G><Y><E><G><A><D><C><R><E><I><K><T><A><D><G><C><S><G><V><S><P><S><P><G><S><L><M><T><L><C><L><L><L><L><A><S><Y><R><S><I><Q><L>
Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.<BOP>
Q2M3T9
Q86SQ3
AGRE4_HUMAN
G-protein coupled receptor PGR16
Homo
<M><G><S><R><F><L><L><V><L><L><S><G><A><S><C><P><P><C><P><K><Y><A><S><C><H><N><S><T><H><C><T><C><E><D><G><F><R><A><R><S><G><R><T><Y><F><H><D><S><S><E><K><C><E><D><I><N><E><C><E><T><G><L><A><K><C><K><Y><K><A><Y><C><R><N><K><V><G><G><Y><I><C><S><C><L><V><K><Y><T><L><F><N><F><L><A><G><I><I><D><Y><D><H><P><D><C><Y><E><N><N><S><Q><G><T><T><Q><S><N><V><D><I><W><V><S><G><V><K><P><G><F><G><K><Q><L><P><G><D><K><R><T><K><H><I><C><V><Y><W><E><G><S><E><G><G><W><S><T><E><G><C><S><H><V><H><S><N><G><S><Y><T><K><C><K><C><F><H><L><S><S><F><A><V><L><V><A><L><A><P><K><E><D><P><V><L><T><V><I><T><Q><V><G><L><T><I><S><L><L><C><L><F><L><A><I><L><T><F><L><L><C><R><P><I><Q><N><T><S><T><S><L><H><L><E><L><S><L><C><L><F><L><A><H><L><L><F><L><T><G><I><N><R><T><E><P><E><V><L><C><S><I><I><A><G><L><L><H><F><L><Y><L><A><C><F><T><W><M><L><L><E><G><L><H><L><F><L><T><V><R><N><L><K><V><A><N><Y><T><S><T><G><R><F><K><K><R><F><M><Y><P><V><G><Y><G><I><P><A><V><I><I><A><V><S><A><I><V><G><P><Q><N><Y><G><T><F><T><C><W><L><K><L><D><K><G><F><I><W><S><F><M><G><P><V><A><V><I><I><L><I><N><L><V><F><Y><F><Q><V><L><W><I><L><R><S><K><L><S><S><L><N><K><E><V><S><T><I><Q><D><T><R><V><M><T><F><K><A><I><S><Q><L><F><I><L><G><C><S><W><G><L><G><F><F><M><V><E><E><V><G><K><T><I><G><S><I><I><A><Y><S><F><T><I><I><N><T><L><Q><G><V><L><L><F><V><V><H><C><L><L><N><R><Q><V><R><L><I><I><L><S><V><I><S><L><V><P><K><S><N>
May mediate the cellular interaction between myeloid cells and B-cells.<BOP>
Q86SQ3
Q9NWW0
HPIP_HUMAN
HCF-1 beta-propeller-interacting protein
Homo
<M><I><L><Q><Q><P><L><Q><R><G><P><Q><G><G><A><Q><R><L><P><R><A><A><L><G><V><T><W><G><L><D><A><S><S><P><L><R><G><A><V><P><M><S><T><K><R><R><L><E><E><E><Q><E><P><L><R><K><Q><F><L><S><E><E><N><M><A><T><H><F><S><Q><L><S><L><H><N><D><H><P><Y><C><S><P><P><M><T><F><S><P><A><L><P><P><L><R><S><P><C><S><E><L><L><L><W><R><Y><P><G><S><L><I><P><E><A><L><R><L><L><R><L><G><D><T><P><S><P><P><Y><P><A><T><P><A><G><D><I><M><E><L>
Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.<BOP>
Q9NWW0
Q8TAD8
SNIP1_HUMAN
FHA domain-containing protein SNIP1
Homo
<M><K><A><V><K><S><E><R><E><R><G><S><R><R><R><H><R><D><G><D><V><V><L><P><A><G><V><V><V><K><Q><E><R><L><S><P><E><V><A><P><P><A><H><R><R><P><D><H><S><G><G><S><P><S><P><P><T><S><E><P><A><R><S><G><H><R><G><N><R><A><R><G><V><S><R><S><P><P><K><K><K><N><K><A><S><G><R><R><S><K><S><P><R><S><K><R><N><R><S><P><H><H><S><T><V><K><V><K><Q><E><R><E><D><H><P><R><R><G><R><E><D><R><Q><H><R><E><P><S><E><Q><E><H><R><R><A><R><N><S><D><R><D><R><H><R><G><H><S><H><Q><R><R><T><S><N><E><R><P><G><S><G><Q><G><Q><G><R><D><R><D><T><Q><N><L><Q><A><Q><E><E><E><R><E><F><Y><N><A><R><R><R><E><H><R><Q><R><N><D><V><G><G><G><G><S><E><S><Q><E><L><V><P><R><P><G><G><N><N><K><E><K><E><V><P><A><K><E><K><P><S><F><E><L><S><G><A><L><L><E><D><T><N><T><F><R><G><V><V><I><K><Y><S><E><P><P><E><A><R><I><P><K><K><R><W><R><L><Y><P><F><K><N><D><E><V><L><P><V><M><Y><I><H><R><Q><S><A><Y><L><L><G><R><H><R><R><I><A><D><I><P><I><D><H><P><S><C><S><K><Q><H><A><V><F><Q><Y><R><L><V><E><Y><T><R><A><D><G><T><V><G><R><R><V><K><P><Y><I><I><D><L><G><S><G><N><G><T><F><L><N><N><K><R><I><E><P><Q><R><Y><Y><E><L><K><E><K><D><V><L><K><F><G><F><S><S><R><E><Y><V><L><L><H><E><S><S><D><T><S><E><I><D><R><K><D><D><E><D><E><E><E><E><E><E><V><S><D><S>
Required for pre-mRNA splicing as component of the spliceosome . Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.<BOP>
Q8TAD8
P01730
CD4_HUMAN
T-cell surface antigen T4/Leu-3
Homo
<M><N><R><G><V><P><F><R><H><L><L><L><V><L><Q><L><A><L><L><P><A><A><T><Q><G><K><K><V><V><L><G><K><K><G><D><T><V><E><L><T><C><T><A><S><Q><K><K><S><I><Q><F><H><W><K><N><S><N><Q><I><K><I><L><G><N><Q><G><S><F><L><T><K><G><P><S><K><L><N><D><R><A><D><S><R><R><S><L><W><D><Q><G><N><F><P><L><I><I><K><N><L><K><I><E><D><S><D><T><Y><I><C><E><V><E><D><Q><K><E><E><V><Q><L><L><V><F><G><L><T><A><N><S><D><T><H><L><L><Q><G><Q><S><L><T><L><T><L><E><S><P><P><G><S><S><P><S><V><Q><C><R><S><P><R><G><K><N><I><Q><G><G><K><T><L><S><V><S><Q><L><E><L><Q><D><S><G><T><W><T><C><T><V><L><Q><N><Q><K><K><V><E><F><K><I><D><I><V><V><L><A><F><Q><K><A><S><S><I><V><Y><K><K><E><G><E><Q><V><E><F><S><F><P><L><A><F><T><V><E><K><L><T><G><S><G><E><L><W><W><Q><A><E><R><A><S><S><S><K><S><W><I><T><F><D><L><K><N><K><E><V><S><V><K><R><V><T><Q><D><P><K><L><Q><M><G><K><K><L><P><L><H><L><T><L><P><Q><A><L><P><Q><Y><A><G><S><G><N><L><T><L><A><L><E><A><K><T><G><K><L><H><Q><E><V><N><L><V><V><M><R><A><T><Q><L><Q><K><N><L><T><C><E><V><W><G><P><T><S><P><K><L><M><L><S><L><K><L><E><N><K><E><A><K><V><S><K><R><E><K><A><V><W><V><L><N><P><E><A><G><M><W><Q><C><L><L><S><D><S><G><Q><V><L><L><E><S><N><I><K><V><L><P><T><W><S><T><P><V><Q><P><M><A><L><I><V><L><G><G><V><A><G><L><L><L><F><I><G><L><G><I><F><F><C><V><R><C><R><H><R><R><R><Q><A><E><R><M><S><Q><I><K><R><L><L><S><E><K><K><T><C><Q><C><P><H><R><F><Q><K><T><C><S><P><I>
(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) . Down-regulated by HIV-1 Vpu . Acts as a receptor for Human Herpes virus 7/HHV-7 .<BOP>
P01730
P43626
KI2L1_HUMAN
p58.1 MHC class-I-specific NK receptor
Homo
<M><S><L><L><V><V><S><M><A><C><V><G><F><F><L><L><Q><G><A><W><P><H><E><G><V><H><R><K><P><S><L><L><A><H><P><G><P><L><V><K><S><E><E><T><V><I><L><Q><C><W><S><D><V><M><F><E><H><F><L><L><H><R><E><G><M><F><N><D><T><L><R><L><I><G><E><H><H><D><G><V><S><K><A><N><F><S><I><S><R><M><T><Q><D><L><A><G><T><Y><R><C><Y><G><S><V><T><H><S><P><Y><Q><V><S><A><P><S><D><P><L><D><I><V><I><I><G><L><Y><E><K><P><S><L><S><A><Q><P><G><P><T><V><L><A><G><E><N><V><T><L><S><C><S><S><R><S><S><Y><D><M><Y><H><L><S><R><E><G><E><A><H><E><R><R><L><P><A><G><P><K><V><N><G><T><F><Q><A><D><F><P><L><G><P><A><T><H><G><G><T><Y><R><C><F><G><S><F><H><D><S><P><Y><E><W><S><K><S><S><D><P><L><L><V><S><V><T><G><N><P><S><N><S><W><P><S><P><T><E><P><S><S><K><T><G><N><P><R><H><L><H><I><L><I><G><T><S><V><V><I><I><L><F><I><L><L><F><F><L><L><H><R><W><C><S><N><K><K><N><A><A><V><M><D><Q><E><S><A><G><N><R><T><A><N><S><E><D><S><D><E><Q><D><P><Q><E><V><T><Y><T><Q><L><N><H><C><V><F><T><Q><R><K><I><T><R><P><S><Q><R><P><K><T><P><P><T><D><I><I><V><Y><T><E><L><P><N><A><E><S><R><S><K><V><V><S><C><P>
Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.<BOP>
P43626
P0C7V9
ME15P_HUMAN
Methyltransferase-like protein 15 pseudogene 1
Homo
<M><L><R><Y><P><Y><F><C><R><M><Y><K><E><C><L><S><C><W><L><E><S><G><I><P><N><L><G><V><W><P><K><R><I><H><T><T><A><E><K><Y><R><E><Y><E><A><R><E><Q><T><D><Q><T><Q><V><Q><E><L><H><R><S><Q><D><R><D><F><E><T><M><A><K><L><H><I><P><V><M><V><D><E><V><V><H><C><L><S><P><Q><K><G><Q><I><F><L><D><M><T><F><G><S><G><G><H><T><K><A><I><L><Q><K><E><S><D><I><V><L><Y><A><L><D><R><D><P><T><A><Y><A><L><A><E><H><L><S><E><L><Y><P><K><Q><I><R><A><M><L><G><Q><F><S><Q><A><E><A><L><L><M><K><A><G><V><Q><P><G><T><F><D><G><V><L><M><D><L><G><C><S><S><M><Q><L><D><T><P><E><R><G><S><S><L><R><K><D><G><P><L><D><I><R><M><D><G><G><R><N><I><S><S><L><C><Y><L><Y><T><E><R><L><T><T><A><I><Y><L><Y><C><H><Q><D><F><P><G><S><S><H><I><C><E><Q>
Probable S-adenosyl-L-methionine-dependent methyltransferase.<BOP>
P0C7V9
Q29980
MICB_HUMAN
MHC class I polypeptide-related sequence B
Homo
<M><G><L><G><R><V><L><L><F><L><A><V><A><F><P><F><A><P><P><A><A><A><A><E><P><H><S><L><R><Y><N><L><M><V><L><S><Q><D><G><S><V><Q><S><G><F><L><A><E><G><H><L><D><G><Q><P><F><L><R><Y><D><R><Q><K><R><R><A><K><P><Q><G><Q><W><A><E><N><V><L><G><A><K><T><W><D><T><E><T><E><D><L><T><E><N><G><Q><D><L><R><R><T><L><T><H><I><K><D><Q><K><G><G><L><H><S><L><Q><E><I><R><V><C><E><I><H><E><D><S><S><T><R><G><S><R><H><F><Y><Y><D><G><E><L><F><L><S><Q><N><L><E><T><Q><E><S><T><V><P><Q><S><S><R><A><Q><T><L><A><M><N><V><T><N><F><W><K><E><D><A><M><K><T><K><T><H><Y><R><A><M><Q><A><D><C><L><Q><K><L><Q><R><Y><L><K><S><G><V><A><I><R><R><T><V><P><P><M><V><N><V><T><C><S><E><V><S><E><G><N><I><T><V><T><C><R><A><S><S><F><Y><P><R><N><I><T><L><T><W><R><Q><D><G><V><S><L><S><H><N><T><Q><Q><W><G><D><V><L><P><D><G><N><G><T><Y><Q><T><W><V><A><T><R><I><R><Q><G><E><E><Q><R><F><T><C><Y><M><E><H><S><G><N><H><G><T><H><P><V><P><S><G><K><A><L><V><L><Q><S><Q><R><T><D><F><P><Y><V><S><A><A><M><P><C><F><V><I><I><I><I><L><C><V><P><C><C><K><K><K><T><S><A><A><E><G><P><E><L><V><S><L><Q><V><L><D><Q><H><P><V><G><T><G><D><H><R><D><A><A><Q><L><G><F><Q><P><L><M><S><A><T><G><S><T><G><S><T><E><G><T>
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.<BOP>
Q29980
C9JUS6
ADM5_HUMAN
Putative adrenomedullin-5-like protein
Homo
<M><T><I><H><I><L><I><L><L><L><L><L><A><F><S><A><Q><G><D><L><D><T><A><A><R><R><G><Q><H><Q><V><P><Q><H><R><G><H><V><C><Y><L><G><V><C><R><T><H><R><L><A><E><I><I><Y><W><I><R><C><L><H><Q><G><A><L><G><E><G><Q><P><R><A><P><G><P><L><Q><L><W><A><P><P><V><A><R><G><G><S><P><A><R><F><P><G><F><R><P><A><A><R><G><L><A><Q><C><P><A><R><W><V><T><S><G><T><A><R><P><L><L><G><F><S><L><P><I><C><M><L><E><L><L><L><H><I><S><S><P><L><T><P><A><P><E><T><V><F><P><S><P><S><P><G><C><D>
Probable non-functional remnant of adrenomedullin-5.<BOP>
C9JUS6
Q99567
NUP88_HUMAN
Nucleoporin Nup88
Homo
<M><A><A><A><E><G><P><V><G><D><G><E><L><W><Q><T><W><L><P><N><H><V><V><F><L><R><L><R><E><G><L><K><N><Q><S><P><T><E><A><E><K><P><A><S><S><S><L><P><S><S><P><P><P><Q><L><L><T><R><N><V><V><F><G><L><G><G><E><L><F><L><W><D><G><E><D><S><S><F><L><V><V><R><L><R><G><P><S><G><G><G><E><E><P><A><L><S><Q><Y><Q><R><L><L><C><I><N><P><P><L><F><E><I><Y><Q><V><L><L><S><P><T><Q><H><H><V><A><L><I><G><I><K><G><L><M><V><L><E><L><P><K><R><W><G><K><N><S><E><F><E><G><G><K><S><T><V><N><C><S><T><T><P><V><A><E><R><F><F><T><S><S><T><S><L><T><L><K><H><A><A><W><Y><P><S><E><I><L><D><P><H><V><V><L><L><T><S><D><N><V><I><R><I><Y><S><L><R><E><P><Q><T><P><T><N><V><I><I><L><S><E><A><E><E><E><S><L><V><L><N><K><G><R><A><Y><T><A><S><L><G><E><T><A><V><A><F><D><F><G><P><L><A><A><V><P><K><T><L><F><G><Q><N><G><K><D><E><V><V><A><Y><P><L><Y><I><L><Y><E><N><G><E><T><F><L><T><Y><I><S><L><L><H><S><P><G><N><I><G><K><L><L><G><P><L><P><M><H><P><A><A><E><D><N><Y><G><Y><D><A><C><A><V><L><C><L><P><C><V><P><N><I><L><V><I><A><T><E><S><G><M><L><Y><H><C><V><V><L><E><G><E><E><E><D><D><H><T><S><E><K><S><W><D><S><R><I><D><L><I><P><S><L><Y><V><F><E><C><V><E><L><E><L><A><L><K><L><A><S><G><E><D><D><P><F><D><S><D><F><S><C><P><V><K><L><H><R><D><P><K><C><P><S><R><Y><H><C><T><H><E><A><G><V><H><S><V><G><L><T><W><I><H><K><L><H><K><F><L><G><S><D><E><E><D><K><D><S><L><Q><E><L><S><T><E><Q><K><C><F><V><E><H><I><L><C><T><K><P><L><P><C><R><Q><P><A><P><I><R><G><F><W><I><V><P><D><I><L><G><P><T><M><I><C><I><T><S><T><Y><E><C><L><I><W><P><L><L><S><T><V><H><P><A><S><P><P><L><L><C><T><R><E><D><V><E><V><A><E><S><P><L><R><V><L><A><E><T><P><D><S><F><E><K><H><I><R><S><I><L><Q><R><S><V><A><N><P><A><F><L><K><A><S><E><K><D><I><A><P><P><P><E><E><C><L><Q><L><L><S><R><A><T><Q><V><F><R><E><Q><Y><I><L><K><Q><D><L><A><K><E><E><I><Q><R><R><V><K><L><L><C><D><Q><K><K><K><Q><L><E><D><L><S><Y><C><R><E><E><R><K><S><L><R><E><M><A><E><R><L><A><D><K><Y><E><E><A><K><E><K><Q><E><D><I><M><N><R><M><K><K><L><L><H><S><F><H><S><E><L><P><V><L><S><D><S><E><R><D><M><K><K><E><L><Q><L><I><P><D><Q><L><R><H><L><G><N><A><I><K><Q><V><T><M><K><K><D><Y><Q><Q><Q><K><M><E><K><V><L><S><L><P><K><P><T><I><I><L><S><A><Y><Q><R><K><C><I><Q><S><I><L><K><E><E><G><E><H><I><R><E><M><V><K><Q><I><N><D><I><R><N><H><V><N><F>
Component of nuclear pore complex.<BOP>
Q99567
A0A183
LCE6A_HUMAN
Late cornified envelope protein 6A
Homo
<M><S><Q><Q><K><Q><Q><S><W><K><P><P><N><V><P><K><C><S><P><P><Q><R><S><N><P><C><L><A><P><Y><S><T><P><C><G><A><P><H><S><E><G><C><H><S><S><S><Q><R><P><E><V><Q><K><P><R><R><A><R><Q><K><L><R><C><L><S><R><G><T><T><Y><H><C><K><E><E><E><C><E><G><D>
Precursors of the cornified envelope of the stratum corneum.<BOP>
A0A183
Q8NGD1
OR4N2_HUMAN
Olfactory receptor OR14-8
Homo
<M><E><S><E><N><R><T><V><I><R><E><F><I><L><L><G><L><T><Q><S><Q><D><I><Q><L><L><V><F><V><L><V><L><I><F><Y><F><I><I><L><P><G><N><F><L><I><I><F><T><I><K><S><D><P><G><L><T><A><P><L><Y><F><F><L><G><N><L><A><F><L><D><A><S><Y><S><F><I><V><A><P><R><M><L><V><D><F><L><S><A><K><K><I><I><S><Y><R><G><C><I><T><Q><L><F><F><L><H><F><L><G><G><G><E><G><L><L><L><V><V><M><A><F><D><R><Y><I><A><I><C><R><P><L><H><Y><P><T><V><M><N><P><R><T><C><Y><A><M><M><L><A><L><W><L><G><G><F><V><H><S><I><I><Q><V><V><L><I><L><R><L><P><F><C><G><P><N><Q><L><D><N><F><F><C><D><V><P><Q><V><I><K><L><A><C><T><D><T><F><V><V><E><L><L><M><V><F><N><S><G><L><M><T><L><L><C><F><L><G><L><L><A><S><Y><A><V><I><L><C><R><I><R><G><S><S><S><E><A><K><N><K><A><M><S><T><C><I><T><H><I><I><V><I><F><F><M><F><G><P><G><I><F><I><Y><T><R><P><F><R><A><F><P><A><D><K><V><V><S><L><F><H><T><V><I><F><P><L><L><N><P><V><I><Y><T><L><R><N><Q><E><V><K><A><S><M><K><K><V><F><N><K><H><I><A>
Odorant receptor.<BOP>
Q8NGD1
A6NED2
RCCD1_HUMAN
RCC1 domain-containing protein 1
Homo
<M><A><E><E><R><P><G><A><W><F><G><F><G><F><C><G><F><G><Q><E><L><G><S><G><R><G><R><Q><V><H><S><P><S><P><L><R><A><G><V><D><I><C><R><V><S><A><S><W><S><Y><T><A><F><V><T><R><G><G><R><L><E><L><S><G><S><A><S><G><A><A><G><R><C><K><D><A><W><A><S><E><G><L><L><A><V><L><R><A><G><P><G><P><E><A><L><L><Q><V><W><A><A><E><S><A><L><R><G><E><P><L><W><A><Q><N><V><V><P><E><A><E><G><E><D><D><P><A><G><E><A><Q><A><G><R><L><P><L><L><P><C><A><R><A><Y><V><S><P><R><A><P><F><Y><R><P><L><A><P><E><L><R><A><R><Q><L><E><L><G><A><E><H><A><L><L><L><D><A><A><G><Q><V><F><S><W><G><G><G><R><H><G><Q><L><G><H><G><T><L><E><A><E><L><E><P><R><L><L><E><A><L><Q><G><L><V><M><A><E><V><A><A><G><G><W><H><S><V><C><V><S><E><T><G><D><I><Y><I><W><G><W><N><E><S><G><Q><L><A><L><P><T><R><N><L><A><E><D><G><E><T><V><A><R><E><A><T><E><L><N><E><D><G><S><Q><V><K><R><T><G><G><A><E><D><G><A><P><A><P><F><I><A><V><Q><P><F><P><A><L><L><D><L><P><M><G><S><D><A><V><K><A><S><C><G><S><R><H><T><A><V><V><T><R><T><G><E><L><Y><T><W><G><W><G><K><Y><G><Q><L><G><H><E><D><T><T><S><L><D><R><P><R><R><V><E><Y><F><V><D><K><Q><L><Q><V><K><A><V><T><C><G><P><W><N><T><Y><V><Y><A><V><E><K><G><K><S>
Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 . Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation . Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 .<BOP>
A6NED2
Q9H611
PIF1_HUMAN
PIF1/RRM3 DNA helicase-like protein
Homo
<M><L><S><G><I><E><A><A><A><G><E><Y><E><D><S><E><L><R><C><R><V><A><V><E><E><L><S><P><G><G><Q><P><R><R><R><Q><A><L><R><T><A><E><L><S><L><G><R><N><E><R><R><E><L><M><L><R><L><Q><A><P><G><P><A><G><R><P><R><C><F><P><L><R><A><A><R><L><F><T><R><F><A><E><A><G><R><S><T><L><R><L><P><A><H><D><T><P><G><A><G><A><V><Q><L><L><L><S><D><C><P><P><D><R><L><R><R><F><L><R><T><L><R><L><K><L><A><A><A><P><G><P><G><P><A><S><A><R><A><Q><L><L><G><P><R><P><R><D><F><V><T><I><S><P><V><Q><P><E><E><R><R><L><R><A><A><T><R><V><P><D><T><T><L><V><K><R><P><V><E><P><Q><A><G><A><E><P><S><T><E><A><P><R><W><P><L><P><V><K><R><L><S><L><P><S><T><K><P><Q><L><S><E><E><Q><A><A><V><L><R><A><V><L><K><G><Q><S><I><F><F><T><G><S><A><G><T><G><K><S><Y><L><L><K><R><I><L><G><S><L><P><P><T><G><T><V><A><T><A><S><T><G><V><A><A><C><H><I><G><G><T><T><L><H><A><F><A><G><I><G><S><G><Q><A><P><L><A><Q><C><V><A><L><A><Q><R><P><G><V><R><Q><G><W><L><N><C><Q><R><L><V><I><D><E><I><S><M><V><E><A><D><L><F><D><K><L><E><A><V><A><R><A><V><R><Q><Q><N><K><P><F><G><G><I><Q><L><I><I><C><G><D><F><L><Q><L><P><P><V><T><K><G><S><Q><P><P><R><F><C><F><Q><S><K><S><W><K><R><C><V><P><V><T><L><E><L><T><K><V><W><R><Q><A><D><Q><T><F><I><S><L><L><Q><A><V><R><L><G><R><C><S><D><E><V><T><R><Q><L><Q><A><T><A><S><H><K><V><G><R><D><G><I><V><A><T><R><L><C><T><H><Q><D><D><V><A><L><T><N><E><R><R><L><Q><E><L><P><G><K><V><H><R><F><E><A><M><D><S><N><P><E><L><A><S><T><L><D><A><Q><C><P><V><S><Q><L><L><Q><L><K><L><G><A><Q><V><M><L><V><K><N><L><S><V><S><R><G><L><V><N><G><A><R><G><V><V><V><G><F><E><A><E><G><R><G><L><P><Q><V><R><F><L><C><G><V><T><E><V><I><H><A><D><R><W><T><V><Q><A><T><G><G><Q><L><L><S><R><Q><Q><L><P><L><Q><L><A><W><A><M><S><I><H><K><S><Q><G><M><T><L><D><C><V><E><I><S><L><G><R><V><F><A><S><G><Q><A><Y><V><A><L><S><R><A><R><S><L><Q><G><L><R><V><L><D><F><D><P><M><A><V><R><C><D><P><R><V><L><H><F><Y><A><T><L><R><R><G><R><S><L><S><L><E><S><P><D><D><D><E><A><A><S><D><Q><E><N><M><D><P><I><L>
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.<BOP>
Q9H611
P78337
PITX1_HUMAN
Paired-like homeodomain transcription factor 1
Homo
<M><D><A><F><K><G><G><M><S><L><E><R><L><P><E><G><L><R><P><P><P><P><P><P><H><D><M><G><P><A><F><H><L><A><R><P><A><D><P><R><E><P><L><E><N><S><A><S><E><S><S><D><T><E><L><P><E><K><E><R><G><G><E><P><K><G><P><E><D><S><G><A><G><G><T><G><C><G><G><A><D><D><P><A><K><K><K><K><Q><R><R><Q><R><T><H><F><T><S><Q><Q><L><Q><E><L><E><A><T><F><Q><R><N><R><Y><P><D><M><S><M><R><E><E><I><A><V><W><T><N><L><T><E><P><R><V><R><V><W><F><K><N><R><R><A><K><W><R><K><R><E><R><N><Q><Q><L><D><L><C><K><G><G><Y><V><P><Q><F><S><G><L><V><Q><P><Y><E><D><V><Y><A><A><G><Y><S><Y><N><N><W><A><A><K><S><L><A><P><A><P><L><S><T><K><S><F><T><F><F><N><S><M><S><P><L><S><S><Q><S><M><F><S><A><P><S><S><I><S><S><M><T><M><P><S><S><M><G><P><G><A><V><P><G><M><P><N><S><G><L><N><N><I><N><N><L><T><G><S><S><L><N><S><A><M><S><P><G><A><C><P><Y><G><T><P><A><S><P><Y><S><V><Y><R><D><T><C><N><S><S><L><A><S><L><R><L><K><S><K><Q><H><S><S><F><G><Y><G><G><L><Q><G><P><A><S><G><L><N><A><C><Q><Y><N><S>
Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.<BOP>
P78337
Q05329
DCE2_HUMAN
Glutamate decarboxylase 65 kDa isoform
Homo
<M><A><S><P><G><S><G><F><W><S><F><G><S><E><D><G><S><G><D><S><E><N><P><G><T><A><R><A><W><C><Q><V><A><Q><K><F><T><G><G><I><G><N><K><L><C><A><L><L><Y><G><D><A><E><K><P><A><E><S><G><G><S><Q><P><P><R><A><A><A><R><K><A><A><C><A><C><D><Q><K><P><C><S><C><S><K><V><D><V><N><Y><A><F><L><H><A><T><D><L><L><P><A><C><D><G><E><R><P><T><L><A><F><L><Q><D><V><M><N><I><L><L><Q><Y><V><V><K><S><F><D><R><S><T><K><V><I><D><F><H><Y><P><N><E><L><L><Q><E><Y><N><W><E><L><A><D><Q><P><Q><N><L><E><E><I><L><M><H><C><Q><T><T><L><K><Y><A><I><K><T><G><H><P><R><Y><F><N><Q><L><S><T><G><L><D><M><V><G><L><A><A><D><W><L><T><S><T><A><N><T><N><M><F><T><Y><E><I><A><P><V><F><V><L><L><E><Y><V><T><L><K><K><M><R><E><I><I><G><W><P><G><G><S><G><D><G><I><F><S><P><G><G><A><I><S><N><M><Y><A><M><M><I><A><R><F><K><M><F><P><E><V><K><E><K><G><M><A><A><L><P><R><L><I><A><F><T><S><E><H><S><H><F><S><L><K><K><G><A><A><A><L><G><I><G><T><D><S><V><I><L><I><K><C><D><E><R><G><K><M><I><P><S><D><L><E><R><R><I><L><E><A><K><Q><K><G><F><V><P><F><L><V><S><A><T><A><G><T><T><V><Y><G><A><F><D><P><L><L><A><V><A><D><I><C><K><K><Y><K><I><W><M><H><V><D><A><A><W><G><G><G><L><L><M><S><R><K><H><K><W><K><L><S><G><V><E><R><A><N><S><V><T><W><N><P><H><K><M><M><G><V><P><L><Q><C><S><A><L><L><V><R><E><E><G><L><M><Q><N><C><N><Q><M><H><A><S><Y><L><F><Q><Q><D><K><H><Y><D><L><S><Y><D><T><G><D><K><A><L><Q><C><G><R><H><V><D><V><F><K><L><W><L><M><W><R><A><K><G><T><T><G><F><E><A><H><V><D><K><C><L><E><L><A><E><Y><L><Y><N><I><I><K><N><R><E><G><Y><E><M><V><F><D><G><K><P><Q><H><T><N><V><C><F><W><Y><I><P><P><S><L><R><T><L><E><D><N><E><E><R><M><S><R><L><S><K><V><A><P><V><I><K><A><R><M><M><E><Y><G><T><T><M><V><S><Y><Q><P><L><G><D><K><V><N><F><F><R><M><V><I><S><N><P><A><A><T><H><Q><D><I><D><F><L><I><E><E><I><E><R><L><G><Q><D><L>
Catalyzes the production of GABA.<BOP>
Q05329
Q9Y5P1
O51B2_HUMAN
Olfactory receptor 51B1
Homo
<M><W><P><N><I><T><A><A><P><F><L><L><T><G><F><P><G><L><E><A><A><H><H><W><I><S><I><P><F><F><A><V><Y><V><C><I><L><L><G><N><G><M><L><L><Y><L><I><K><H><D><H><S><L><H><E><P><M><Y><Y><F><L><T><M><L><A><G><T><D><L><M><V><T><L><T><T><M><P><T><V><M><G><I><L><W><V><N><H><R><E><I><S><S><V><G><C><F><L><Q><A><Y><F><I><H><S><L><S><V><V><E><S><G><S><L><L><A><M><A><Y><D><C><F><I><A><I><R><N><P><L><R><Y><A><S><I><L><T><N><T><R><V><I><A><L><G><V><G><V><F><L><R><G><F><V><S><I><L><P><V><I><L><R><L><F><S><F><S><Y><C><K><S><H><V><I><T><R><A><F><C><L><H><Q><E><I><M><R><L><A><C><A><D><I><T><F><N><R><L><Y><P><V><I><L><I><S><L><T><I><F><L><D><C><L><I><I><L><F><S><Y><I><L><I><L><N><T><V><I><G><I><A><S><G><E><E><R><A><K><A><L><N><T><C><I><S><H><I><S><C><V><L><I><F><Y><V><T><V><M><G><L><T><F><I><Y><R><F><G><K><N><V><P><E><V><V><H><I><I><M><S><Y><I><Y><F><L><F><P><P><L><M><N><P><V><I><Y><S><I><K><T><K><Q><I><Q><Y><G><I><I><R><L><L><S><K><H><R><F><S><S>
Odorant receptor.<BOP>
Q9Y5P1
Q9BY64
UDB28_HUMAN
UDP-glucuronosyltransferase 2B28
Homo
<M><A><L><K><W><T><S><V><L><L><L><I><H><L><G><C><Y><F><S><S><G><S><C><G><K><V><L><V><W><T><G><E><Y><S><H><W><M><N><M><K><T><I><L><K><E><L><V><Q><R><G><H><E><V><T><V><L><A><S><S><A><S><I><L><F><D><P><N><D><A><F><T><L><K><L><E><V><Y><P><T><S><L><T><K><T><E><F><E><N><I><I><M><Q><Q><V><K><R><W><S><D><I><Q><K><D><S><F><W><L><Y><F><S><Q><E><Q><E><I><L><W><E><F><H><D><I><F><R><N><F><C><K><D><V><V><S><N><K><K><V><M><K><K><L><Q><E><S><R><F><D><I><I><F><A><D><A><F><F><P><C><G><E><L><L><A><A><L><L><N><I><P><F><V><Y><S><L><C><F><T><P><G><Y><T><I><E><R><H><S><G><G><L><I><F><P><P><S><Y><I><P><V><V><M><S><K><L><S><D><Q><M><T><F><M><E><R><V><K><N><M><I><Y><V><L><Y><F><D><F><W><F><Q><M><C><D><M><K><K><W><D><Q><F><Y><S><E><V><L><G><R><P><T><T><L><F><E><T><M><G><K><A><D><I><W><L><M><R><N><S><W><S><F><Q><F><P><H><P><F><L><P><N><I><D><F><V><G><G><L><H><C><K><P><A><K><P><L><P><K><E><M><E><E><F><V><Q><S><S><G><E><N><G><V><V><V><F><S><L><G><S><V><I><S><N><M><T><A><E><R><A><N><V><I><A><T><A><L><A><K><I><P><Q><K><V><L><W><R><F><D><G><N><K><P><D><A><L><G><L><N><T><R><L><Y><K><W><I><P><Q><N><D><L><L><G><L><P><K><T><R><A><F><I><T><H><G><G><A><N><G><I><Y><E><A><I><Y><H><G><I><P><M><V><G><I><P><L><F><W><D><Q><P><D><N><I><A><H><M><K><A><K><G><A><A><V><R><L><D><F><H><T><M><S><S><T><D><L><L><N><A><L><K><T><V><I><N><D><P><S><Y><K><E><N><V><M><K><L><S><I><I><Q><H><D><Q><P><V><K><P><L><H><R><A><V><F><W><I><E><F><V><M><C><H><K><G><A><K><H><L><R><V><A><A><R><D><L><T><W><F><Q><Y><H><S><L><D><V><I><G><F><L><L><A><C><V><A><T><V><I><F><V><V><T><K><F><C><L><F><C><F><W><K><F><A><R><K><G><K><K><G><K><R><D>
Lack UDP-glucuronosyltransferase (UGT) activity.<BOP>
Q9BY64
Q9P0T4
ZN581_HUMAN
Zinc finger protein 581
Homo
<M><L><V><L><P><S><P><C><P><Q><P><L><A><F><S><S><V><E><T><M><E><G><P><P><R><R><T><C><R><S><P><E><P><G><P><S><S><S><I><G><S><P><Q><A><S><S><P><P><R><P><N><H><Y><L><L><I><D><T><Q><G><V><P><Y><T><V><L><V><D><E><E><S><Q><R><E><P><G><A><S><G><A><P><G><Q><K><K><C><Y><S><C><P><V><C><S><R><V><F><E><Y><M><S><Y><L><Q><R><H><S><I><T><H><S><E><V><K><P><F><E><C><D><I><C><G><K><A><F><K><R><A><S><H><L><A><R><H><H><S><I><H><L><A><G><G><G><R><P><H><G><C><P><L><C><P><R><R><F><R><D><A><G><E><L><A><Q><H><S><R><V><H><S><G><E><R><P><F><Q><C><P><H><C><P><R><R><F><M><E><Q><N><T><L><Q><K><H><T><R><W><K><H><P>
May be involved in transcriptional regulation.<BOP>
Q9P0T4
Q8NG77
O2T12_HUMAN
Olfactory receptor OR1-57
Homo
<M><E><M><R><N><T><T><P><D><F><I><L><L><G><L><F><N><H><T><R><A><H><Q><V><L><F><M><M><L><L><A><T><V><L><T><S><L><F><S><N><A><L><M><I><L><L><I><H><W><D><H><R><L><H><R><P><M><Y><F><L><L><S><Q><L><S><L><M><D><M><M><L><V><S><T><T><V><P><K><M><A><A><D><Y><L><T><G><N><K><A><I><S><R><A><G><C><G><V><Q><I><F><F><L><P><T><L><G><G><G><E><C><F><L><L><A><A><M><A><Y><D><R><Y><A><A><V><C><H><P><L><R><Y><P><T><L><M><S><W><Q><L><C><L><R><M><T><M><S><S><W><L><L><G><A><A><D><G><L><L><Q><A><V><A><T><L><S><F><P><Y><C><G><A><H><E><I><D><H><F><F><C><E><A><P><V><L><V><R><L><A><C><A><D><T><S><V><F><E><N><A><M><Y><I><C><C><V><L><M><L><L><V><P><F><S><L><I><L><S><S><Y><G><L><I><L><A><A><V><L><L><M><R><S><T><E><A><R><K><K><A><F><A><T><C><S><S><H><V><A><V><V><G><L><F><Y><G><A><G><I><F><T><Y><M><R><P><K><S><H><R><S><T><N><H><D><K><V><V><S><A><F><Y><T><M><F><T><P><L><L><N><P><L><I><Y><S><V><R><N><S><E><V><K><E><A><L><K><R><W><L><G><T><C><V><N><L><K><H><Q><Q><N><E><A><H><R><S><R>
Odorant receptor.<BOP>
Q8NG77
P10114
RAP2A_HUMAN
RbBP-30
Homo
<M><R><E><Y><K><V><V><V><L><G><S><G><G><V><G><K><S><A><L><T><V><Q><F><V><T><G><T><F><I><E><K><Y><D><P><T><I><E><D><F><Y><R><K><E><I><E><V><D><S><S><P><S><V><L><E><I><L><D><T><A><G><T><E><Q><F><A><S><M><R><D><L><Y><I><K><N><G><Q><G><F><I><L><V><Y><S><L><V><N><Q><Q><S><F><Q><D><I><K><P><M><R><D><Q><I><I><R><V><K><R><Y><E><K><V><P><V><I><L><V><G><N><K><V><D><L><E><S><E><R><E><V><S><S><S><E><G><R><A><L><A><E><E><W><G><C><P><F><M><E><T><S><A><K><S><K><T><M><V><D><E><L><F><A><E><I><V><R><Q><M><N><Y><A><A><Q><P><D><K><D><D><P><C><C><S><A><C><N><I><Q>
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.<BOP>
P10114
Q6UVW9
CLC2A_HUMAN
Proliferation-induced lymphocyte-associated receptor
Homo
<M><I><N><P><E><L><R><D><G><R><A><D><G><F><I><H><R><I><V><P><K><L><I><Q><N><W><K><I><G><L><M><C><F><L><S><I><I><I><T><T><V><C><I><I><M><I><A><T><W><S><K><H><A><K><P><V><A><C><S><G><D><W><L><G><V><R><D><K><C><F><Y><F><S><D><D><T><R><N><W><T><A><S><K><I><F><C><S><L><Q><K><A><E><L><A><Q><I><D><T><Q><E><D><M><E><F><L><K><R><Y><A><G><T><D><M><H><W><I><G><L><S><R><K><Q><G><D><S><W><K><W><T><N><G><T><T><F><N><G><W><F><E><I><I><G><N><G><S><F><A><F><L><S><A><D><G><V><H><S><S><R><G><F><I><D><I><K><W><I><C><S><K><P><K><Y><F><L>
Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.<BOP>
Q6UVW9
Q7Z3K6
MIER3_HUMAN
Mesoderm induction early response protein 3
Homo
<M><A><E><A><S><F><G><S><S><S><P><V><G><S><L><S><S><E><D><H><D><F><D><P><T><A><E><M><L><V><H><D><Y><D><D><E><R><T><L><E><E><E><E><M><M><D><E><G><K><N><F><S><S><E><I><E><D><L><E><K><E><G><T><M><P><L><E><D><L><L><A><F><Y><G><Y><E><P><T><I><P><A><V><A><N><S><S><A><N><S><S><P><S><E><L><A><D><E><L><P><D><M><T><L><D><K><E><E><I><A><K><D><L><L><S><G><D><D><E><E><T><Q><S><S><A><D><D><L><T><P><S><V><T><S><H><E><T><S><D><F><F><P><R><P><L><R><S><N><T><A><C><D><G><D><K><E><S><E><V><E><D><V><E><T><D><S><G><N><S><P><E><D><L><R><K><E><I><M><I><G><L><Q><Y><Q><A><E><I><P><P><Y><L><G><E><Y><D><G><N><E><K><V><Y><E><N><E><D><Q><L><L><W><C><P><D><V><V><L><E><S><K><V><K><E><Y><L><V><E><T><S><L><R><T><G><S><E><K><I><M><D><R><I><S><A><G><T><H><T><R><D><N><E><Q><A><L><Y><E><L><L><K><C><N><H><N><I><K><E><A><I><E><R><Y><C><C><N><G><K><A><S><Q><E><G><M><T><A><W><T><E><E><E><C><R><S><F><E><H><A><L><M><L><F><G><K><D><F><H><L><I><Q><K><N><K><V><R><T><R><T><V><A><E><C><V><A><F><Y><Y><M><W><K><K><S><E><R><Y><D><Y><F><A><Q><Q><T><R><F><G><K><K><R><Y><N><H><H><P><G><V><T><D><Y><M><D><R><L><V><D><E><T><E><A><L><G><G><T><V><N><A><S><A><L><T><S><N><R><P><E><P><I><P><D><Q><Q><L><N><I><L><N><S><F><T><A><S><D><L><T><A><L><T><N><S><V><A><T><V><C><D><P><T><D><V><N><C><L><D><D><S><F><P><P><L><G><N><T><P><R><G><Q><V><N><H><V><P><V><V><T><E><E><L><L><T><L><P><S><N><G><E><S><D><C><F><N><L><F><E><T><G><F><Y><H><S><E><L><N><P><M><N><M><C><S><E><E><S><E><R><P><A><K><R><L><K><M><G><I><A><V><P><E><S><F><M><N><E><V><S><V><N><N><L><G><V><D><F><E><N><H><T><H><H><I><T><S><A><K><M><A><V><S><V><A><D><F><G><S><L><S><A><N><E><T><N><G><F><I><S><A><H><A><L><H><Q><H><A><A><L><H><S><E>
Transcriptional repressor.<BOP>
Q7Z3K6
P17022
ZNF18_HUMAN
Zinc finger protein with KRAB and SCAN domains 6
Homo
<M><P><V><D><L><G><Q><A><L><G><L><L><P><S><L><A><K><A><E><D><S><Q><F><S><E><S><D><A><A><L><Q><E><E><L><S><S><P><E><T><A><R><Q><L><F><R><Q><F><R><Y><Q><V><M><S><G><P><H><E><T><L><K><Q><L><R><K><L><C><F><Q><W><L><Q><P><E><V><H><T><K><E><Q><I><L><E><I><L><M><L><E><Q><F><L><T><I><L><P><G><E><I><Q><M><W><V><R><K><Q><C><P><G><S><G><E><E><A><V><T><L><V><E><S><L><K><G><D><P><Q><R><L><W><Q><W><I><S><I><Q><V><L><G><Q><D><I><L><S><E><K><M><E><S><P><S><C><Q><V><G><E><V><E><P><H><L><E><V><V><P><Q><E><L><G><L><E><N><S><S><S><G><P><G><E><L><L><S><H><I><V><K><E><E><S><D><T><E><A><E><L><A><L><A><A><S><Q><P><A><R><L><E><E><R><L><I><R><D><Q><D><L><G><A><S><L><L><P><A><A><P><Q><E><Q><W><R><Q><L><D><S><T><Q><K><E><Q><Y><W><D><L><M><L><E><T><Y><G><K><M><V><S><G><A><G><I><S><H><P><K><S><D><L><T><N><S><I><E><F><G><E><E><L><A><G><I><Y><L><H><V><N><E><K><I><P><R><P><T><C><I><G><D><R><Q><E><N><D><K><E><N><L><N><L><E><N><H><R><D><Q><E><L><L><H><A><S><C><Q><A><S><G><E><V><P><S><Q><A><S><L><R><G><F><F><T><E><D><E><P><G><C><F><G><E><G><E><N><L><P><E><A><L><Q><N><I><Q><D><E><G><T><G><E><Q><L><S><P><Q><E><R><I><S><E><K><Q><L><G><Q><H><L><P><N><P><H><S><G><E><M><S><T><M><W><L><E><E><K><R><E><T><S><Q><K><G><Q><P><R><A><P><M><A><Q><K><L><P><T><C><R><E><C><G><K><T><F><Y><R><N><S><Q><L><I><F><H><Q><R><T><H><T><G><E><T><Y><F><Q><C><T><I><C><K><K><A><F><L><R><S><S><D><F><V><K><H><Q><R><T><H><T><G><E><K><P><C><K><C><D><Y><C><G><K><G><F><S><D><F><S><G><L><R><H><H><E><K><I><H><T><G><E><K><P><Y><K><C><P><I><C><E><K><S><F><I><Q><R><S><N><F><N><R><H><Q><R><V><H><T><G><E><K><P><Y><K><C><S><H><C><G><K><S><F><S><W><S><S><S><L><D><K><H><Q><R><S><H><L><G><K><K><P><F><Q>
May be involved in transcriptional regulation.<BOP>
P17022
P38405
GNAL_HUMAN
Adenylate cyclase-stimulating G alpha protein, olfactory type
Homo
<M><G><C><L><G><G><N><S><K><T><T><E><D><Q><G><V><D><E><K><E><R><R><E><A><N><K><K><I><E><K><Q><L><Q><K><E><R><L><A><Y><K><A><T><H><R><L><L><L><L><G><A><G><E><S><G><K><S><T><I><V><K><Q><M><R><I><L><H><V><N><G><F><N><P><E><E><K><K><Q><K><I><L><D><I><R><K><N><V><K><D><A><I><V><T><I><V><S><A><M><S><T><I><I><P><P><V><P><L><A><N><P><E><N><Q><F><R><S><D><Y><I><K><S><I><A><P><I><T><D><F><E><Y><S><Q><E><F><F><D><H><V><K><K><L><W><D><D><E><G><V><K><A><C><F><E><R><S><N><E><Y><Q><L><I><D><C><A><Q><Y><F><L><E><R><I><D><S><V><S><L><V><D><Y><T><P><T><D><Q><D><L><L><R><C><R><V><L><T><S><G><I><F><E><T><R><F><Q><V><D><K><V><N><F><H><M><F><D><V><G><G><Q><R><D><E><R><R><K><W><I><Q><C><F><N><D><V><T><A><I><I><Y><V><A><A><C><S><S><Y><N><M><V><I><R><E><D><N><N><T><N><R><L><R><E><S><L><D><L><F><E><S><I><W><N><N><R><W><L><R><T><I><S><I><I><L><F><L><N><K><Q><D><M><L><A><E><K><V><L><A><G><K><S><K><I><E><D><Y><F><P><E><Y><A><N><Y><T><V><P><E><D><A><T><P><D><A><G><E><D><P><K><V><T><R><A><K><F><F><I><R><D><L><F><L><R><I><S><T><A><T><G><D><G><K><H><Y><C><Y><P><H><F><T><C><A><V><D><T><E><N><I><R><R><V><F><N><D><C><R><D><I><I><Q><R><M><H><L><K><Q><Y><E><L><L>
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.<BOP>
P38405
Q12901
ZN155_HUMAN
Zinc finger protein 155
Homo
<M><T><T><F><K><E><A><V><T><F><K><D><V><A><V><V><F><T><E><E><E><L><G><L><L><D><P><A><Q><R><K><L><Y><R><D><V><M><L><E><N><F><R><N><L><L><S><V><G><H><Q><P><F><H><Q><D><T><C><H><F><L><R><E><E><K><F><W><M><M><G><T><A><T><Q><R><E><G><N><S><G><G><K><I><Q><T><E><L><E><S><V><P><E><A><G><A><H><E><E><W><S><C><Q><Q><I><W><E><Q><I><A><K><D><L><T><R><S><Q><D><S><I><I><N><N><S><Q><F><F><E><N><G><D><V><P><S><Q><V><E><A><G><L><P><T><I><H><T><G><Q><K><P><S><Q><G><G><K><C><K><Q><S><I><S><D><V><P><I><F><D><L><P><Q><Q><L><Y><S><E><E><K><S><Y><T><C><D><E><C><G><K><S><I><C><Y><I><S><A><L><H><V><H><Q><R><V><H><V><G><E><K><L><F><M><C><D><V><C><G><K><E><F><S><Q><S><S><H><L><Q><T><H><Q><R><V><H><T><G><E><K><P><F><K><C><E><Q><C><G><K><G><F><S><R><R><S><A><L><N><V><H><R><K><L><H><T><G><E><K><P><Y><I><C><E><A><C><G><K><A><F><I><H><D><S><Q><L><K><E><H><K><R><I><H><T><G><E><K><P><F><K><C><D><I><C><G><K><T><F><Y><F><R><S><R><L><K><S><H><S><M><V><H><T><G><E><K><P><F><R><C><D><T><C><D><K><S><F><H><Q><R><S><A><L><N><R><H><C><M><V><H><T><G><E><K><P><Y><R><C><E><Q><C><G><K><G><F><I><G><R><L><D><F><Y><K><H><Q><V><V><H><T><G><E><K><P><Y><N><C><K><E><C><G><K><S><F><R><W><S><S><C><L><L><N><H><Q><R><V><H><S><G><E><K><S><F><K><C><E><E><C><G><K><G><F><Y><T><N><S><Q><L><S><S><H><Q><R><S><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><G><Y><V><T><K><F><N><L><D><L><H><Q><R><V><H><T><G><E><R><P><Y><N><C><K><E><C><G><K><N><F><S><R><A><S><S><I><L><N><H><K><R><L><H><C><Q><K><K><P><F><K><C><E><D><C><G><K><R><L><V><H><R><T><Y><R><K><D><Q><P><R><D><Y><S><G><E><N><P><S><K><C><E><D><C><G><R><R><Y><K><R><R><L><N><L><D><I><L><L><S><L><F><L><N><D><T>
May be involved in transcriptional regulation.<BOP>
Q12901
Q96LJ8
UBX10_HUMAN
UBX domain-containing protein 3
Homo
<M><A><T><E><A><P><V><N><I><A><P><P><E><C><S><T><V><V><S><T><A><V><D><S><L><I><W><Q><P><N><S><L><N><M><H><M><I><R><P><K><S><A><K><G><R><T><R><P><S><L><Q><K><S><Q><G><V><E><V><C><A><H><H><I><P><S><P><P><P><A><I><P><Y><E><L><P><S><S><Q><K><P><G><A><C><A><P><K><S><P><N><Q><G><A><S><D><E><I><P><E><L><Q><Q><Q><V><P><T><G><A><S><S><S><L><N><K><Y><P><V><L><P><S><I><N><R><K><N><L><E><E><E><A><V><E><T><V><A><K><K><A><S><S><L><Q><L><S><S><I><R><A><L><Y><Q><D><E><T><G><T><M><K><T><S><E><E><D><S><R><A><R><A><C><A><V><E><R><K><F><I><V><R><T><K><K><Q><G><S><S><R><A><G><N><L><E><E><P><S><D><Q><E><P><R><L><L><L><A><V><R><S><P><T><G><Q><R><F><V><R><H><F><R><P><T><D><D><L><Q><T><I><V><A><V><A><E><Q><K><N><K><T><S><Y><R><H><C><S><I><E><T><M><E><V><P><R><R><R><F><S><D><L><T><K><S><L><Q><E><C><R><I><P><H><K><S><V><L><G><I><S><L><E><D><G><E><G><W><P>
VCP/p97-binding protein required for ciliogenesis . Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia . UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 .<BOP>
Q96LJ8
Q6P9H4
CNKR3_HUMAN
Maguin-like protein
Homo
<M><E><P><V><T><K><W><S><P><K><Q><V><V><D><W><T><R><G><L><D><D><C><L><Q><Q><Y><V><H><K><F><E><R><E><K><I><N><G><E><Q><L><L><Q><I><S><H><Q><D><L><E><E><L><G><V><T><R><I><G><H><Q><E><L><V><L><E><A><V><D><L><L><C><A><L><N><Y><G><L><E><T><D><N><M><K><N><L><V><L><K><L><R><A><S><S><H><N><L><Q><N><Y><I><S><S><R><R><K><S><P><A><Y><D><G><N><T><S><R><K><A><P><N><E><F><L><T><S><V><V><E><L><I><G><A><A><K><A><L><L><A><W><L><D><R><A><P><F><T><G><I><T><D><F><S><V><T><K><N><K><I><I><Q><L><C><L><D><L><T><T><T><V><Q><K><D><C><F><V><A><E><M><E><D><K><V><L><T><V><V><K><V><L><N><G><I><C><D><K><T><I><R><S><T><T><D><P><V><M><S><Q><C><A><C><L><E><E><V><H><L><P><N><I><K><P><G><E><G><L><G><M><Y><I><K><S><T><Y><D><G><L><H><V><I><T><G><T><T><E><N><S><P><A><D><R><S><Q><K><I><H><A><G><D><E><V><I><Q><V><N><Q><Q><T><V><V><G><W><Q><L><K><N><L><V><K><K><L><R><E><N><P><T><G><V><V><L><L><L><K><K><R><P><T><G><S><F><N><F><T><P><A><P><L><K><N><L><R><W><K><P><P><L><V><Q><T><S><P><P><P><A><T><T><Q><S><P><E><S><T><M><D><T><S><L><K><K><E><K><S><A><I><L><D><L><Y><I><P><P><P><P><A><V><P><Y><S><P><R><D><E><N><G><S><F><V><Y><G><G><S><S><K><C><K><Q><P><L><P><G><P><K><G><S><E><S><P><N><S><F><L><D><Q><E><S><R><R><R><R><F><T><I><A><D><S><D><Q><L><P><G><Y><S><V><E><T><N><I><L><P><T><K><M><R><E><K><T><P><S><Y><G><K><P><R><P><L><S><M><P><A><D><G><N><W><M><G><I><V><D><P><F><A><R><P><R><G><H><G><R><K><G><E><D><A><L><C><R><Y><F><S><N><E><R><I><P><P><I><I><E><E><S><S><S><P><P><Y><R><F><S><R><P><T><T><E><R><H><L><V><R><G><A><D><Y><I><R><G><S><R><C><Y><I><N><S><D><L><H><S><S><A><T><I><P><F><Q><E><E><G><T><K><K><K><S><G><S><S><A><T><K><S><S><S><T><E><P><S><L><L><V><S><W><F><T><R><L><K><L><L><T><H>
Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).<BOP>
Q6P9H4
O75319
DUS11_HUMAN
Phosphatase that interacts with RNA/RNP complex 1
Homo
<M><R><N><S><E><T><L><E><R><G><V><G><G><C><R><V><F><S><C><L><G><S><Y><P><G><I><E><G><A><G><L><A><L><L><A><D><L><A><L><G><G><R><L><L><G><T><H><M><S><Q><W><H><H><P><R><S><G><W><G><R><R><R><D><F><S><G><R><S><S><A><K><K><K><G><G><N><H><I><P><E><R><W><K><D><Y><L><P><V><G><Q><R><M><P><G><T><R><F><I><A><F><K><V><P><L><Q><K><S><F><E><K><K><L><A><P><E><E><C><F><S><P><L><D><L><F><N><K><I><R><E><Q><N><E><E><L><G><L><I><I><D><L><T><Y><T><Q><R><Y><Y><K><P><E><D><L><P><E><T><V><P><Y><L><K><I><F><T><V><G><H><Q><V><P><D><D><E><T><I><F><K><F><K><H><A><V><N><G><F><L><K><E><N><K><D><N><D><K><L><I><G><V><H><C><T><H><G><L><N><R><T><G><Y><L><I><C><R><Y><L><I><D><V><E><G><V><R><P><D><D><A><I><E><L><F><N><R><C><R><G><H><C><L><E><R><Q><N><Y><I><E><D><L><Q><N><G><P><I><R><K><N><W><N><S><S><V><P><R><S><S><D><F><E><D><S><A><H><L><M><Q><P><V><H><N><K><P><V><K><Q><G><P><R><Y><N><L><H><Q><I><Q><G><H><S><A><P><R><H><F><H><T><Q><T><Q><S><L><Q><Q><S><V><R><K><F><S><E><N><P><H><V><Y><Q><R><H><H><L><P><P><P><G><P><P><G><E><D><Y><S><H><R><R><Y><S><W><N><V><K><P><N><A><S><R><A><A><Q><D><R><R><R><W><Y><P><Y><N><Y><S><R><L><S><Y><P><A><C><W><E><W><T><Q>
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.<BOP>
O75319
O14733
MP2K7_HUMAN
c-Jun N-terminal kinase kinase 2
Homo
<M><A><A><S><S><L><E><Q><K><L><S><R><L><E><A><K><L><K><Q><E><N><R><E><A><R><R><R><I><D><L><N><L><D><I><S><P><Q><R><P><R><P><T><L><Q><L><P><L><A><N><D><G><G><S><R><S><P><S><S><E><S><S><P><Q><H><P><T><P><P><A><R><P><R><H><M><L><G><L><P><S><T><L><F><T><P><R><S><M><E><S><I><E><I><D><Q><K><L><Q><E><I><M><K><Q><T><G><Y><L><T><I><G><G><Q><R><Y><Q><A><E><I><N><D><L><E><N><L><G><E><M><G><S><G><T><C><G><Q><V><W><K><M><R><F><R><K><T><G><H><V><I><A><V><K><Q><M><R><R><S><G><N><K><E><E><N><K><R><I><L><M><D><L><D><V><V><L><K><S><H><D><C><P><Y><I><V><Q><C><F><G><T><F><I><T><N><T><D><V><F><I><A><M><E><L><M><G><T><C><A><E><K><L><K><K><R><M><Q><G><P><I><P><E><R><I><L><G><K><M><T><V><A><I><V><K><A><L><Y><Y><L><K><E><K><H><G><V><I><H><R><D><V><K><P><S><N><I><L><L><D><E><R><G><Q><I><K><L><C><D><F><G><I><S><G><R><L><V><D><S><K><A><K><T><R><S><A><G><C><A><A><Y><M><A><P><E><R><I><D><P><P><D><P><T><K><P><D><Y><D><I><R><A><D><V><W><S><L><G><I><S><L><V><E><L><A><T><G><Q><F><P><Y><K><N><C><K><T><D><F><E><V><L><T><K><V><L><Q><E><E><P><P><L><L><P><G><H><M><G><F><S><G><D><F><Q><S><F><V><K><D><C><L><T><K><D><H><R><K><R><P><K><Y><N><K><L><L><E><H><S><F><I><K><R><Y><E><T><L><E><V><D><V><A><S><W><F><K><D><V><M><A><K><T><E><S><P><R><T><S><G><V><L><S><Q><P><H><L><P><F><F><R>
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is
O14733
Q5TA79
LCE2A_HUMAN
Late envelope protein 9
Homo
<M><S><C><Q><Q><N><Q><Q><Q><C><Q><P><P><P><K><C><P><P><K><C><P><P><K><C><P><P><K><C><R><P><Q><C><P><A><P><C><P><P><P><V><S><S><C><C><G><P><S><S><G><G><C><C><G><S><S><S><G><G><C><C><S><S><G><G><G><G><C><C><L><S><H><H><R><P><R><L><F><H><R><H><R><H><Q><S><P><D><C><C><E><C><E><P><S><G><G><S><G><C><C><H><S><S><G><D><C><C>
Precursors of the cornified envelope of the stratum corneum.<BOP>
Q5TA79
Q9Y679
AUP1_HUMAN
Ancient ubiquitous protein 1
Homo
<M><E><L><P><S><G><P><G><P><E><R><L><F><D><S><H><R><L><P><G><D><C><F><L><L><L><V><L><L><L><Y><A><P><V><G><F><C><L><L><V><L><R><L><F><L><G><I><H><V><F><L><V><S><C><A><L><P><D><S><V><L><R><R><F><V><V><R><T><M><C><A><V><L><G><L><V><A><R><Q><E><D><S><G><L><R><D><H><S><V><R><V><L><I><S><N><H><V><T><P><F><D><H><N><I><V><N><L><L><T><T><C><S><T><P><L><L><N><S><P><P><S><F><V><C><W><S><R><G><F><M><E><M><N><G><R><G><E><L><V><E><S><L><K><R><F><C><A><S><T><R><L><P><P><T><P><L><L><L><F><P><E><E><E><A><T><N><G><R><E><G><L><L><R><F><S><S><W><P><F><S><I><Q><D><V><V><Q><P><L><T><L><Q><V><Q><R><P><L><V><S><V><T><V><S><D><A><S><W><V><S><E><L><L><W><S><L><F><V><P><F><T><V><Y><Q><V><R><W><L><R><P><V><H><R><Q><L><G><E><A><N><E><E><F><A><L><R><V><Q><Q><L><V><A><K><E><L><G><Q><T><G><T><R><L><T><P><A><D><K><A><E><H><M><K><R><Q><R><H><P><R><L><R><P><Q><S><A><Q><S><S><F><P><P><S><P><G><P><S><P><D><V><Q><L><A><T><L><A><Q><R><V><K><E><V><L><P><H><V><P><L><G><V><I><Q><R><D><L><A><K><T><G><C><V><D><L><T><I><T><N><L><L><E><G><A><V><A><F><M><P><E><D><I><T><K><G><T><Q><S><L><P><T><A><S><A><S><K><F><P><S><S><G><P><V><T><P><Q><P><T><A><L><T><F><A><K><S><S><W><A><R><Q><E><S><L><Q><E><R><K><Q><A><L><Y><E><Y><A><R><R><R><F><T><E><R><R><A><Q><E><A><D>
(Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.<BOP>
Q9Y679
Q8NBN7
RDH13_HUMAN
Short chain dehydrogenase/reductase family 7C member 3
Homo
<M><S><R><Y><L><L><P><L><S><A><L><G><T><V><A><G><A><A><V><L><L><K><D><Y><V><T><G><G><A><C><P><S><K><A><T><I><P><G><K><T><V><I><V><T><G><A><N><T><G><I><G><K><Q><T><A><L><E><L><A><R><R><G><G><N><I><I><L><A><C><R><D><M><E><K><C><E><A><A><A><K><D><I><R><G><E><T><L><N><H><H><V><N><A><R><H><L><D><L><A><S><L><K><S><I><R><E><F><A><A><K><I><I><E><E><E><E><R><V><D><I><L><I><N><N><A><G><V><M><R><C><P><H><W><T><T><E><D><G><F><E><M><Q><F><G><V><N><H><L><G><H><F><L><L><T><N><L><L><L><D><K><L><K><A><S><A><P><S><R><I><I><N><L><S><S><L><A><H><V><A><G><H><I><D><F><D><D><L><N><W><Q><T><R><K><Y><N><T><K><A><A><Y><C><Q><S><K><L><A><I><V><L><F><T><K><E><L><S><R><R><L><Q><G><S><G><V><T><V><N><A><L><H><P><G><V><A><R><T><E><L><G><R><H><T><G><I><H><G><S><T><F><S><S><T><T><L><G><P><I><F><W><L><L><V><K><S><P><E><L><A><A><Q><P><S><T><Y><L><A><V><A><E><E><L><A><D><V><S><G><K><Y><F><D><G><L><K><Q><K><A><P><A><P><E><A><E><D><E><E><V><A><R><R><L><W><A><E><S><A><R><L><V><G><L><E><A><P><S><V><R><E><Q><P><L><P><R>
Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency . Has no activity toward steroids .<BOP>
Q8NBN7
Q8N4E7
FTMT_HUMAN
Ferritin, mitochondrial
Homo
<M><L><S><C><F><R><L><L><S><R><H><I><S><P><S><L><A><S><L><R><P><V><R><C><C><F><A><L><P><L><R><W><A><P><G><R><P><L><D><P><R><Q><I><A><P><R><R><P><L><A><A><A><A><S><S><R><D><P><T><G><P><A><A><G><P><S><R><V><R><Q><N><F><H><P><D><S><E><A><A><I><N><R><Q><I><N><L><E><L><Y><A><S><Y><V><Y><L><S><M><A><Y><Y><F><S><R><D><D><V><A><L><N><N><F><S><R><Y><F><L><H><Q><S><R><E><E><T><E><H><A><E><K><L><M><R><L><Q><N><Q><R><G><G><R><I><R><L><Q><D><I><K><K><P><E><Q><D><D><W><E><S><G><L><H><A><M><E><C><A><L><L><L><E><K><N><V><N><Q><S><L><L><E><L><H><A><L><A><S><D><K><G><D><P><H><L><C><D><F><L><E><T><Y><Y><L><N><E><Q><V><K><S><I><K><E><L><G><D><H><V><H><N><L><V><K><M><G><A><P><D><A><G><L><A><E><Y><L><F><D><T><H><T><L><G><N><E><N><K><Q><N>
Catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form . Important for iron homeostasis . Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation .<BOP>
Q8N4E7
Q8WWB7
GLMP_HUMAN
Lysosomal protein NCU-G1
Homo
<M><R><G><S><V><E><C><T><W><G><W><G><H><C><A><P><S><P><L><L><L><W><T><L><L><L><F><A><A><P><F><G><L><L><G><E><K><T><R><Q><V><S><L><E><V><I><P><N><W><L><G><P><L><Q><N><L><L><H><I><R><A><V><G><T><N><S><T><L><H><Y><V><W><S><S><L><G><P><L><A><V><V><M><V><A><T><N><T><P><H><S><T><L><S><V><N><W><S><L><L><L><S><P><E><P><D><G><G><L><M><V><L><P><K><D><S><I><Q><F><S><S><A><L><V><F><T><R><L><L><E><F><D><S><T><N><V><S><D><T><A><A><K><P><L><G><R><P><Y><P><P><Y><S><L><A><D><F><S><W><N><N><I><T><D><S><L><D><P><A><T><L><S><A><T><F><Q><G><H><P><M><N><D><P><T><R><T><F><A><N><G><S><L><A><F><R><V><Q><A><F><S><R><S><S><R><P><A><Q><P><P><R><L><L><H><T><A><D><T><C><Q><L><E><V><A><L><I><G><A><S><P><R><G><N><R><S><L><F><G><L><E><V><A><T><L><G><Q><G><P><D><C><P><S><M><Q><E><Q><H><S><I><D><D><E><Y><A><P><A><V><F><Q><L><D><Q><L><L><W><G><S><L><P><S><G><F><A><Q><W><R><P><V><A><Y><S><Q><K><P><G><G><R><E><S><A><L><P><C><Q><A><S><P><L><H><P><A><L><A><Y><S><L><P><Q><S><P><I><V><R><A><F><F><G><S><Q><N><N><F><C><A><F><N><L><T><F><G><A><S><T><G><P><G><Y><W><D><Q><H><Y><L><S><W><S><M><L><L><G><V><G><F><P><P><V><D><G><L><S><P><L><V><L><G><I><M><A><V><A><L><G><A><P><G><L><M><L><L><G><G><G><L><V><L><L><L><H><H><K><K><Y><S><E><Y><Q><S><I><N>
Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.<BOP>
Q8WWB7
O15151
MDM4_HUMAN
p53-binding protein Mdm4
Homo
<M><T><S><F><S><T><S><A><Q><C><S><T><S><D><S><A><C><R><I><S><P><G><Q><I><N><Q><V><R><P><K><L><P><L><L><K><I><L><H><A><A><G><A><Q><G><E><M><F><T><V><K><E><V><M><H><Y><L><G><Q><Y><I><M><V><K><Q><L><Y><D><Q><Q><E><Q><H><M><V><Y><C><G><G><D><L><L><G><E><L><L><G><R><Q><S><F><S><V><K><D><P><S><P><L><Y><D><M><L><R><K><N><L><V><T><L><A><T><A><T><T><D><A><A><Q><T><L><A><L><A><Q><D><H><S><M><D><I><P><S><Q><D><Q><L><K><Q><S><A><E><E><S><S><T><S><R><K><R><T><T><E><D><D><I><P><T><L><P><T><S><E><H><K><C><I><H><S><R><E><D><E><D><L><I><E><N><L><A><Q><D><E><T><S><R><L><D><L><G><F><E><E><W><D><V><A><G><L><P><W><W><F><L><G><N><L><R><S><N><Y><T><P><R><S><N><G><S><T><D><L><Q><T><N><Q><D><V><G><T><A><I><V><S><D><T><T><D><D><L><W><F><L><N><E><S><V><S><E><Q><L><G><V><G><I><K><V><E><A><A><D><T><E><Q><T><S><E><E><V><G><K><V><S><D><K><K><V><I><E><V><G><K><N><D><D><L><E><D><S><K><S><L><S><D><D><T><D><V><E><V><T><S><E><D><E><W><Q><C><T><E><C><K><K><F><N><S><P><S><K><R><Y><C><F><R><C><W><A><L><R><K><D><W><Y><S><D><C><S><K><L><T><H><S><L><S><T><S><D><I><T><A><I><P><E><K><E><N><E><G><N><D><V><P><D><C><R><R><T><I><S><A><P><V><V><R><P><K><D><A><Y><I><K><K><E><N><S><K><L><F><D><P><C><N><S><V><E><F><L><D><L><A><H><S><S><E><S><Q><E><T><I><S><S><M><G><E><Q><L><D><N><L><S><E><Q><R><T><D><T><E><N><M><E><D><C><Q><N><L><L><K><P><C><S><L><C><E><K><R><P><R><D><G><N><I><I><H><G><R><T><G><H><L><V><T><C><F><H><C><A><R><R><L><K><K><A><G><A><S><C><P><I><C><K><K><E><I><Q><L><V><I><K><V><F><I><A>
Along with MDM2, contributes to TP53 regulation . Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<BOP>
O15151
Q8NI22
MCFD2_HUMAN
Neural stem cell-derived neuronal survival protein
Homo
<M><T><M><R><S><L><L><R><T><P><F><L><C><G><L><L><W><A><F><C><A><P><G><A><R><A><E><E><P><A><A><S><F><S><Q><P><G><S><M><G><L><D><K><N><T><V><H><D><Q><E><H><I><M><E><H><L><E><G><V><I><N><K><P><E><A><E><M><S><P><Q><E><L><Q><L><H><Y><F><K><M><H><D><Y><D><G><N><N><L><L><D><G><L><E><L><S><T><A><I><T><H><V><H><K><E><E><G><S><E><Q><A><P><L><M><S><E><D><E><L><I><N><I><I><D><G><V><L><R><D><D><D><K><N><N><D><G><Y><I><D><Y><A><E><F><A><K><S><L><Q>
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.<BOP>
Q8NI22
P02776
PLF4_HUMAN
Endothelial cell growth inhibitor
Homo
<M><S><S><A><A><G><F><C><A><S><R><P><G><L><L><F><L><G><L><L><L><L><P><L><V><V><A><F><A><S><A><E><A><E><E><D><G><D><L><Q><C><L><C><V><K><T><T><S><Q><V><R><P><R><H><I><T><S><L><E><V><I><K><A><G><P><H><C><P><T><A><Q><L><I><A><T><L><K><N><G><R><K><I><C><L><D><L><Q><A><P><L><Y><K><K><I><I><K><K><L><L><E><S>
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.<BOP>
P02776
Q13573
SNW1_HUMAN
Ski-interacting protein
Homo
<M><A><L><T><S><F><L><P><A><P><T><Q><L><S><Q><D><Q><L><E><A><E><E><K><A><R><S><Q><R><S><R><Q><T><S><L><V><S><S><R><R><E><P><P><P><Y><G><Y><R><K><G><W><I><P><R><L><L><E><D><F><G><D><G><G><A><F><P><E><I><H><V><A><Q><Y><P><L><D><M><G><R><K><K><K><M><S><N><A><L><A><I><Q><V><D><S><E><G><K><I><K><Y><D><A><I><A><R><Q><G><Q><S><K><D><K><V><I><Y><S><K><Y><T><D><L><V><P><K><E><V><M><N><A><D><D><P><D><L><Q><R><P><D><E><E><A><I><K><E><I><T><E><K><T><R><V><A><L><E><K><S><V><S><Q><K><V><A><A><A><M><P><V><R><A><A><D><K><L><A><P><A><Q><Y><I><R><Y><T><P><S><Q><Q><G><V><A><F><N><S><G><A><K><Q><R><V><I><R><M><V><E><M><Q><K><D><P><M><E><P><P><R><F><K><I><N><K><K><I><P><R><G><P><P><S><P><P><A><P><V><M><H><S><P><S><R><K><M><T><V><K><E><Q><Q><E><W><K><I><P><P><C><I><S><N><W><K><N><A><K><G><Y><T><I><P><L><D><K><R><L><A><A><D><G><R><G><L><Q><T><V><H><I><N><E><N><F><A><K><L><A><E><A><L><Y><I><A><D><R><K><A><R><E><A><V><E><M><R><A><Q><V><E><R><K><M><A><Q><K><E><K><E><K><H><E><E><K><L><R><E><M><A><Q><K><A><R><E><R><R><A><G><I><K><T><H><V><E><K><E><D><G><E><A><R><E><R><D><E><I><R><H><D><R><R><K><E><R><Q><H><D><R><N><L><S><R><A><A><P><D><K><R><S><K><L><Q><R><N><E><N><R><D><I><S><E><V><I><A><L><G><V><P><N><P><R><T><S><N><E><V><Q><Y><D><Q><R><L><F><N><Q><S><K><G><M><D><S><G><F><A><G><G><E><D><E><I><Y><N><V><Y><D><Q><A><W><R><G><G><K><D><M><A><Q><S><I><Y><R><P><S><K><N><L><D><K><D><M><Y><G><D><D><L><E><A><R><I><K><T><N><R><F><V><P><D><K><E><F><S><G><S><D><R><R><Q><R><G><R><E><G><P><V><Q><F><E><E><D><P><F><G><L><D><K><F><L><E><E><A><K><Q><H><G><G><S><K><R><P><S><D><S><S><R><P><K><E><H><E><H><E><G><K><K><R><R><K><E>
(Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters.<BOP>
Q13573
P27694
RFA1_HUMAN
Replication protein A 70 kDa DNA-binding subunit, N-terminally processed
Homo
<M><V><G><Q><L><S><E><G><A><I><A><A><I><M><Q><K><G><D><T><N><I><K><P><I><L><Q><V><I><N><I><R><P><I><T><T><G><N><S><P><P><R><Y><R><L><L><M><S><D><G><L><N><T><L><S><S><F><M><L><A><T><Q><L><N><P><L><V><E><E><E><Q><L><S><S><N><C><V><C><Q><I><H><R><F><I><V><N><T><L><K><D><G><R><R><V><V><I><L><M><E><L><E><V><L><K><S><A><E><A><V><G><V><K><I><G><N><P><V><P><Y><N><E><G><L><G><Q><P><Q><V><A><P><P><A><P><A><A><S><P><A><A><S><S><R><P><Q><P><Q><N><G><S><S><G><M><G><S><T><V><S><K><A><Y><G><A><S><K><T><F><G><K><A><A><G><P><S><L><S><H><T><S><G><G><T><Q><S><K><V><V><P><I><A><S><L><T><P><Y><Q><S><K><W><T><I><C><A><R><V><T><N><K><S><Q><I><R><T><W><S><N><S><R><G><E><G><K><L><F><S><L><E><L><V><D><E><S><G><E><I><R><A><T><A><F><N><E><Q><V><D><K><F><F><P><L><I><E><V><N><K><V><Y><Y><F><S><K><G><T><L><K><I><A><N><K><Q><F><T><A><V><K><N><D><Y><E><M><T><F><N><N><E><T><S><V><M><P><C><E><D><D><H><H><L><P><T><V><Q><F><D><F><T><G><I><D><D><L><E><N><K><S><K><D><S><L><V><D><I><I><G><I><C><K><S><Y><E><D><A><T><K><I><T><V><R><S><N><N><R><E><V><A><K><R><N><I><Y><L><M><D><T><S><G><K><V><V><T><A><T><L><W><G><E><D><A><D><K><F><D><G><S><R><Q><P><V><L><A><I><K><G><A><R><V><S><D><F><G><G><R><S><L><S><V><L><S><S><S><T><I><I><A><N><P><D><I><P><E><A><Y><K><L><R><G><W><F><D><A><E><G><Q><A><L><D><G><V><S><I><S><D><L><K><S><G><G><V><G><G><S><N><T><N><W><K><T><L><Y><E><V><K><S><E><N><L><G><Q><G><D><K><P><D><Y><F><S><S><V><A><T><V><V><Y><L><R><K><E><N><C><M><Y><Q><A><C><P><T><Q><D><C><N><K><K><V><I><D><Q><Q><N><G><L><Y><R><C><E><K><C><D><T><E><F><P><N><F><K><Y><R><M><I><L><S><V><N><I><A><D><F><Q><E><N><Q><W><V><T><C><F><Q><E><S><A><E><A><I><L><G><Q><N><A><A><Y><L><G><E><L><K><D><K><N><E><Q><A><F><E><E><V><F><Q><N><A><N><F><R><S><F><I><F><R><V><R><V><K><V><E><T><Y><N><D><E><S><R><I><K><A><T><V><M><D><V><K><P><V><D><Y><R><E><Y><G><R><R><L><V><M><S><I><R><R><S><A><L><M>
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism . Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage . In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response . It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage . Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair . Also plays a role in base excision repair (BER) probably through interaction with UNG . Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance . As part of the alternative replication protein A complex, aRPA, binds single
P27694
P23510
TNFL4_HUMAN
TAX transcriptionally-activated glycoprotein 1
Homo
<M><E><R><V><Q><P><L><E><E><N><V><G><N><A><A><R><P><R><F><E><R><N><K><L><L><L><V><A><S><V><I><Q><G><L><G><L><L><L><C><F><T><Y><I><C><L><H><F><S><A><L><Q><V><S><H><R><Y><P><R><I><Q><S><I><K><V><Q><F><T><E><Y><K><K><E><K><G><F><I><L><T><S><Q><K><E><D><E><I><M><K><V><Q><N><N><S><V><I><I><N><C><D><G><F><Y><L><I><S><L><K><G><Y><F><S><Q><E><V><N><I><S><L><H><Y><Q><K><D><E><E><P><L><F><Q><L><K><K><V><R><S><V><N><S><L><M><V><A><S><L><T><Y><K><D><K><V><Y><L><N><V><T><T><D><N><T><S><L><D><D><F><H><V><N><G><G><E><L><I><L><I><H><Q><N><P><G><E><F><C><V><L>
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.<BOP>
P23510
Q8NGE2
O2AP1_HUMAN
Olfactory receptor OR12-9
Homo
<M><K><N><K><T><V><L><T><E><F><I><L><L><G><L><T><D><V><P><E><L><Q><V><A><V><F><T><F><L><F><L><A><Y><L><L><S><I><L><G><N><L><T><I><L><I><L><T><L><L><D><S><H><L><Q><T><P><M><Y><F><F><L><R><N><F><S><F><L><E><I><S><F><T><N><I><F><I><P><R><V><L><I><S><I><T><T><G><N><K><S><I><S><F><A><G><C><F><T><Q><Y><F><F><A><M><F><L><G><A><T><E><F><Y><L><L><A><A><M><S><Y><D><R><Y><V><A><I><C><K><P><L><H><Y><T><T><I><M><S><S><R><I><C><I><Q><L><I><F><C><S><W><L><G><G><L><M><A><I><I><P><T><I><T><L><M><S><Q><Q><D><F><C><A><S><N><R><L><N><H><Y><F><C><D><Y><E><P><L><L><E><L><S><C><S><D><T><S><L><I><E><K><V><V><F><L><V><A><S><V><T><L><V><V><T><L><V><L><V><I><L><S><Y><A><F><I><I><K><T><I><L><K><L><P><S><A><Q><Q><R><T><K><A><F><S><T><C><S><S><H><M><I><V><I><S><L><S><Y><G><S><C><M><F><M><Y><I><N><P><S><A><K><E><G><D><T><F><N><K><G><V><A><L><L><I><T><S><V><A><P><L><L><N><P><F><I><Y><T><L><R><N><Q><Q><V><K><Q><P><F><K><D><M><V><K><K><L><L><N><L>
Odorant receptor.<BOP>
Q8NGE2
O14717
TRDMT_HUMAN
PuMet
Homo
<M><E><P><L><R><V><L><E><L><Y><S><G><V><G><G><M><H><H><A><L><R><E><S><C><I><P><A><Q><V><V><A><A><I><D><V><N><T><V><A><N><E><V><Y><K><Y><N><F><P><H><T><Q><L><L><A><K><T><I><E><G><I><T><L><E><E><F><D><R><L><S><F><D><M><I><L><M><S><P><P><C><Q><P><F><T><R><I><G><R><Q><G><D><M><T><D><S><R><T><N><S><F><L><H><I><L><D><I><L><P><R><L><Q><K><L><P><K><Y><I><L><L><E><N><V><K><G><F><E><V><S><S><T><R><D><L><L><I><Q><T><I><E><N><C><G><F><Q><Y><Q><E><F><L><L><S><P><T><S><L><G><I><P><N><S><R><L><R><Y><F><L><I><A><K><L><Q><S><E><P><L><P><F><Q><A><P><G><Q><V><L><M><E><F><P><K><I><E><S><V><H><P><Q><K><Y><A><M><D><V><E><N><K><I><Q><E><K><N><V><E><P><N><I><S><F><D><G><S><I><Q><C><S><G><K><D><A><I><L><F><K><L><E><T><A><E><E><I><H><R><K><N><Q><Q><D><S><D><L><S><V><K><M><L><K><D><F><L><E><D><D><T><D><V><N><Q><Y><L><L><P><P><K><S><L><L><R><Y><A><L><L><L><D><I><V><Q><P><T><C><R><R><S><V><C><F><T><K><G><Y><G><S><Y><I><E><G><T><G><S><V><L><Q><T><A><E><D><V><Q><V><E><N><I><Y><K><S><L><T><N><L><S><Q><E><E><Q><I><T><K><L><L><I><L><K><L><R><Y><F><T><P><K><E><I><A><N><L><L><G><F><P><P><E><F><G><F><P><E><K><I><T><V><K><Q><R><Y><R><L><L><G><N><S><L><N><V><H><V><V><A><K><L><I><K><I><L><Y><E>
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).<BOP>
O14717
A0PK00
T120B_HUMAN
Transmembrane protein 120B
Homo
<M><S><G><Q><L><E><R><C><E><R><E><W><H><E><L><E><G><E><F><Q><E><L><Q><E><T><H><R><I><Y><K><Q><K><L><E><E><L><A><A><L><Q><T><L><C><S><S><S><I><S><K><Q><K><K><H><L><K><D><L><K><L><T><L><Q><R><C><K><R><H><A><S><R><E><E><A><E><L><V><Q><Q><M><A><A><N><I><K><E><R><Q><D><V><F><F><D><M><E><A><Y><L><P><K><K><N><G><L><Y><L><N><L><V><L><G><N><V><N><V><T><L><L><S><N><Q><A><K><F><A><Y><K><D><E><Y><E><K><F><K><L><Y><L><T><I><I><L><L><L><G><A><V><A><C><R><F><V><L><H><Y><R><V><T><D><E><V><F><N><F><L><L><V><W><Y><Y><C><T><L><T><I><R><E><S><I><L><I><S><N><G><S><R><I><K><G><W><W><V><S><H><H><Y><V><S><T><F><L><S><G><V><M><L><T><W><P><N><G><P><I><Y><Q><K><F><R><N><Q><F><L><A><F><S><I><F><Q><S><C><V><Q><F><L><Q><Y><Y><Y><Q><R><G><C><L><Y><R><L><R><A><L><G><E><R><N><H><L><D><L><T><V><E><G><F><Q><S><W><M><W><R><G><L><T><F><L><L><P><F><L><F><C><G><H><F><W><Q><L><Y><N><A><V><T><L><F><E><L><S><S><H><E><E><C><R><E><W><Q><V><F><V><L><A><F><T><F><L><I><L><F><L><G><N><F><L><T><T><L><K><V><V><H><A><K><L><Q><K><N><R><G><K><T><K><Q><P>
Necessary for efficient adipogenesis. Does not show ion channel activity.<BOP>
A0PK00
Q8IUZ5
AT2L2_HUMAN
Alanine--glyoxylate aminotransferase 2-like 2
Homo
<M><A><A><D><Q><R><P><K><A><D><T><L><A><L><R><Q><R><L><I><S><S><S><C><R><L><F><F><P><E><D><P><V><K><I><V><R><A><Q><G><Q><Y><M><Y><D><E><Q><G><A><E><Y><I><D><C><I><S><N><V><A><H><V><G><H><C><H><P><L><V><V><Q><A><A><H><E><Q><N><Q><V><L><N><T><N><S><R><Y><L><H><D><N><I><V><D><Y><A><Q><R><L><S><E><T><L><P><E><Q><L><C><V><F><Y><F><L><N><S><G><S><E><A><N><D><L><A><L><R><L><A><R><H><Y><T><G><H><Q><D><V><V><V><L><D><H><A><Y><H><G><H><L><S><S><L><I><D><I><S><P><Y><K><F><R><N><L><D><G><Q><K><E><W><V><H><V><A><P><L><P><D><T><Y><R><G><P><Y><R><E><D><H><P><N><P><A><M><A><Y><A><N><E><V><K><R><V><V><S><S><A><Q><E><K><G><R><K><I><A><A><F><F><A><E><S><L><P><S><V><G><G><Q><I><I><P><P><A><G><Y><F><S><Q><V><A><E><H><I><R><K><A><G><G><V><F><V><A><D><E><I><Q><V><G><F><G><R><V><G><K><H><F><W><A><F><Q><L><Q><G><K><D><F><V><P><D><I><V><T><M><G><K><S><I><G><N><G><H><P><V><A><C><V><A><A><T><Q><P><V><A><R><A><F><E><A><T><G><V><E><Y><F><N><T><F><G><G><S><P><V><S><C><A><V><G><L><A><V><L><N><V><L><E><K><E><Q><L><Q><D><H><A><T><S><V><G><S><F><L><M><Q><L><L><G><Q><Q><K><I><K><H><P><I><V><G><D><V><R><G><V><G><L><F><I><G><V><D><L><I><K><D><E><A><T><R><T><P><A><T><E><E><A><A><Y><L><V><S><R><L><K><E><N><Y><V><L><L><S><T><D><G><P><G><R><N><I><L><K><F><K><P><P><M><C><F><S><L><D><N><A><R><Q><V><V><A><K><L><D><A><I><L><T><D><M><E><E><K><V><R><S><C><E><T><L><R><L><Q><P>
Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde.<BOP>
Q8IUZ5
Q96FT9
IFT43_HUMAN
Intraflagellar transport protein 43 homolog
Homo
<M><E><D><L><L><D><L><D><E><E><L><R><Y><S><L><A><T><S><R><A><K><M><G><R><R><A><Q><Q><E><S><A><Q><A><E><N><H><L><N><G><K><N><S><S><L><T><L><T><G><E><T><S><S><A><K><L><P><R><C><R><Q><G><G><W><A><G><D><S><V><K><A><S><K><F><R><R><K><A><S><E><E><I><E><D><F><R><L><R><P><Q><S><L><N><G><S><D><Y><G><G><D><I><P><I><I><P><D><L><E><E><V><Q><E><E><D><F><V><L><Q><V><A><A><P><P><S><I><Q><I><K><R><V><M><T><Y><R><D><L><D><N><D><L><M><K><Y><S><A><I><Q><T><L><D><G><E><I><D><L><K><L><L><T><K><V><L><A><P><E><H><E><V><R><E><D><D><V><G><W><D><W><D><H><L><F><T><E><V><S><S><E><V><L><T><E><W><D><P><L><Q><T><E><K><E><D><P><A><G><Q><A><R><H><T>
As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis . Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base .<BOP>
Q96FT9
Q13643
FHL3_HUMAN
Skeletal muscle LIM-protein 2
Homo
<M><S><E><S><F><D><C><A><K><C><N><E><S><L><Y><G><R><K><Y><I><Q><T><D><S><G><P><Y><C><V><P><C><Y><D><N><T><F><A><N><T><C><A><E><C><Q><Q><L><I><G><H><D><S><R><E><L><F><Y><E><D><R><H><F><H><E><G><C><F><R><C><C><R><C><Q><R><S><L><A><D><E><P><F><T><C><Q><D><S><E><L><L><C><N><D><C><Y><C><S><A><F><S><S><Q><C><S><A><C><G><E><T><V><M><P><G><S><R><K><L><E><Y><G><G><Q><T><W><H><E><H><C><F><L><C><S><G><C><E><Q><P><L><G><S><R><S><F><V><P><D><K><G><A><H><Y><C><V><P><C><Y><E><N><K><F><A><P><R><C><A><R><C><S><K><T><L><T><Q><G><G><V><T><Y><R><D><Q><P><W><H><R><E><C><L><V><C><T><G><C><Q><T><P><L><A><G><Q><Q><F><T><S><R><D><E><D><P><Y><C><V><A><C><F><G><E><L><F><A><P><K><C><S><S><C><K><R><P><I><V><G><L><G><G><G><K><Y><V><S><F><E><D><R><H><W><H><H><N><C><F><S><C><A><R><C><S><T><S><L><V><G><Q><G><F><V><P><D><G><D><Q><V><L><C><Q><G><C><S><Q><A><G><P>
Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.<BOP>
Q13643
P13598
ICAM2_HUMAN
Intercellular adhesion molecule 2
Homo
<M><S><S><F><G><Y><R><T><L><T><V><A><L><F><T><L><I><C><C><P><G><S><D><E><K><V><F><E><V><H><V><R><P><K><K><L><A><V><E><P><K><G><S><L><E><V><N><C><S><T><T><C><N><Q><P><E><V><G><G><L><E><T><S><L><D><K><I><L><L><D><E><Q><A><Q><W><K><H><Y><L><V><S><N><I><S><H><D><T><V><L><Q><C><H><F><T><C><S><G><K><Q><E><S><M><N><S><N><V><S><V><Y><Q><P><P><R><Q><V><I><L><T><L><Q><P><T><L><V><A><V><G><K><S><F><T><I><E><C><R><V><P><T><V><E><P><L><D><S><L><T><L><F><L><F><R><G><N><E><T><L><H><Y><E><T><F><G><K><A><A><P><A><P><Q><E><A><T><A><T><F><N><S><T><A><D><R><E><D><G><H><R><N><F><S><C><L><A><V><L><D><L><M><S><R><G><G><N><I><F><H><K><H><S><A><P><K><M><L><E><I><Y><E><P><V><S><D><S><Q><M><V><I><I><V><T><V><V><S><V><L><L><S><L><F><V><T><S><V><L><L><C><F><I><F><G><Q><H><L><R><Q><Q><R><M><G><T><Y><G><V><R><A><A><W><R><R><L><P><Q><A><F><R><P>
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.<BOP>
P13598
O60711
LPXN_HUMAN
Leupaxin
Homo
<M><E><E><L><D><A><L><L><E><E><L><E><R><S><T><L><Q><D><S><D><E><Y><S><N><P><A><P><L><P><L><D><Q><H><S><R><K><E><T><N><L><D><E><T><S><E><I><L><S><I><Q><D><N><T><S><P><L><P><A><Q><L><V><Y><T><T><N><I><Q><E><L><N><V><Y><S><E><A><Q><E><P><K><E><S><P><P><P><S><K><T><S><A><A><A><Q><L><D><E><L><M><A><H><L><T><E><M><Q><A><K><V><A><V><R><A><D><A><G><K><K><H><L><P><D><K><Q><D><H><K><A><S><L><D><S><M><L><G><G><L><E><Q><E><L><Q><D><L><G><I><A><T><V><P><K><G><H><C><A><S><C><Q><K><P><I><A><G><K><V><I><H><A><L><G><Q><S><W><H><P><E><H><F><V><C><T><H><C><K><E><E><I><G><S><S><P><F><F><E><R><S><G><L><A><Y><C><P><N><D><Y><H><Q><L><F><S><P><R><C><A><Y><C><A><A><P><I><L><D><K><V><L><T><A><M><N><Q><T><W><H><P><E><H><F><F><C><S><H><C><G><E><V><F><G><A><E><G><F><H><E><K><D><K><K><P><Y><C><R><K><D><F><L><A><M><F><S><P><K><C><G><G><C><N><R><P><V><L><E><N><Y><L><S><A><M><D><T><V><W><H><P><E><C><F><V><C><G><D><C><F><T><S><F><S><T><G><S><F><F><E><L><D><G><R><P><F><C><E><L><H><Y><H><H><R><R><G><T><L><C><H><G><C><G><Q><P><I><T><G><R><C><I><S><A><M><G><Y><K><F><H><P><E><H><F><V><C><A><F><C><L><T><Q><L><S><K><G><I><F><R><E><Q><N><D><K><T><Y><C><Q><P><C><F><N><K><L><F><P><L>
Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.<BOP>
O60711
P48047
ATPO_HUMAN
Oligomycin sensitivity conferral protein
Homo
<M><A><A><P><A><V><S><G><L><S><R><Q><V><R><C><F><S><T><S><V><V><R><P><F><A><K><L><V><R><P><P><V><Q><V><Y><G><I><E><G><R><Y><A><T><A><L><Y><S><A><A><S><K><Q><N><K><L><E><Q><V><E><K><E><L><L><R><V><A><Q><I><L><K><E><P><K><V><A><A><S><V><L><N><P><Y><V><K><R><S><I><K><V><K><S><L><N><D><I><T><A><K><E><R><F><S><P><L><T><T><N><L><I><N><L><L><A><E><N><G><R><L><S><N><T><Q><G><V><V><S><A><F><S><T><M><M><S><V><H><R><G><E><V><P><C><T><V><T><S><A><S><P><L><E><E><A><T><L><S><E><L><K><T><V><L><K><S><F><L><S><Q><G><Q><V><L><K><L><E><A><K><T><D><P><S><I><L><G><G><M><I><V><R><I><G><E><K><Y><V><D><M><S><V><K><T><K><I><Q><K><L><G><R><A><M><R><E><I><V>
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.<BOP>
P48047
Q9P1W9
PIM2_HUMAN
Pim-2h
Homo
<M><L><T><K><P><L><Q><G><P><P><A><P><P><G><T><P><T><P><P><P><G><G><K><D><R><E><A><F><E><A><E><Y><R><L><G><P><L><L><G><K><G><G><F><G><T><V><F><A><G><H><R><L><T><D><R><L><Q><V><A><I><K><V><I><P><R><N><R><V><L><G><W><S><P><L><S><D><S><V><T><C><P><L><E><V><A><L><L><W><K><V><G><A><G><G><G><H><P><G><V><I><R><L><L><D><W><F><E><T><Q><E><G><F><M><L><V><L><E><R><P><L><P><A><Q><D><L><F><D><Y><I><T><E><K><G><P><L><G><E><G><P><S><R><C><F><F><G><Q><V><V><A><A><I><Q><H><C><H><S><R><G><V><V><H><R><D><I><K><D><E><N><I><L><I><D><L><R><R><G><C><A><K><L><I><D><F><G><S><G><A><L><L><H><D><E><P><Y><T><D><F><D><G><T><R><V><Y><S><P><P><E><W><I><S><R><H><Q><Y><H><A><L><P><A><T><V><W><S><L><G><I><L><L><Y><D><M><V><C><G><D><I><P><F><E><R><D><Q><E><I><L><E><A><E><L><H><F><P><A><H><V><S><P><D><C><C><A><L><I><R><R><C><L><A><P><K><P><S><S><R><P><S><L><E><E><I><L><L><D><P><W><M><Q><T><P><A><E><D><V><P><L><N><P><S><K><G><G><P><A><P><L><A><W><S><L><L><P>
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and
Q9P1W9
Q96AP0
ACD_HUMAN
POT1 and TIN2-interacting protein
Homo
<M><A><G><S><G><R><L><V><L><R><P><W><I><R><E><L><I><L><G><S><E><T><P><S><S><P><R><A><G><Q><L><L><E><V><L><Q><D><A><E><A><A><V><A><G><P><S><H><A><P><D><T><S><D><V><G><A><T><L><L><V><S><D><G><T><H><S><V><R><C><L><V><T><R><E><A><L><D><T><S><D><W><E><E><K><E><F><G><F><R><G><T><E><G><R><L><L><L><L><Q><D><C><G><V><H><V><Q><V><A><E><G><G><A><P><A><E><F><Y><L><Q><V><D><R><F><S><L><L><P><T><E><Q><P><R><L><R><V><P><G><C><N><Q><D><L><D><V><Q><K><K><L><Y><D><C><L><E><E><H><L><S><E><S><T><S><S><N><A><G><L><S><L><S><Q><L><L><D><E><M><R><E><D><Q><E><H><Q><G><A><L><V><C><L><A><E><S><C><L><T><L><E><G><P><C><T><A><P><P><V><T><H><W><A><A><S><R><C><K><A><T><G><E><A><V><Y><T><V><P><S><S><M><L><C><I><S><E><N><D><Q><L><I><L><S><S><L><G><P><C><Q><R><T><Q><G><P><E><L><P><P><P><D><P><A><L><Q><D><L><S><L><T><L><I><A><S><P><P><S><S><P><S><S><S><G><T><P><A><L><P><G><H><M><S><S><E><E><S><G><T><S><I><S><L><L><P><A><L><S><L><A><A><P><D><P><G><Q><R><S><S><S><Q><P><S><P><A><I><C><S><A><P><A><T><L><T><P><R><S><P><H><A><S><R><T><P><S><S><P><L><Q><S><C><T><P><S><L><S><P><R><S><H><V><P><S><P><H><Q><A><L><V><T><R><P><Q><K><P><S><L><E><F><K><E><F><V><G><L><P><C><K><N><R><P><P><F><P><R><T><G><A><T><R><G><A><Q><E><P><C><S><V><W><E><P><P><K><R><H><R><D><G><S><A><F><Q><Y><E><Y><E><P><P><C><T><S><L><C><A><R><V><Q><A><V><R><L><P><P><Q><L><M><A><W><A><L><H><F><L><M><D><A><Q><P><G><S><E><P><T><P><M>
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.<BOP>
Q96AP0