accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q14406 | CSHL_HUMAN | Lactogen-like | Homo | <M><A><A><G><S><R><T><S><L><L><L><A><F><A><L><L><C><L><P><W><L><Q><E><A><G><A><V><Q><T><V><P><L><S><R><L><F><K><E><A><M><L><Q><A><H><R><A><H><Q><L><A><I><D><T><Y><Q><E><F><I><S><S><W><G><M><E><A><Y><I><T><K><E><Q><K><Y><S><F><L><H><D><S><Q><T><S><F><C><F><S><D><S><I><P><T><S><S><N><M><E><E><T><Q><Q><K><S><N><L><E><L><L><H><I><S><L><L><L><I><E><S><R><L><E><P><V><R><F><L><R><S><T><F><T><N><N><L><V><Y><D><T><S><D><S><D><D><Y><H><L><L><K><D><L><E><E><G><I><Q><M><L><M><G><R><L><E><D><G><S><H><L><T><G><Q><T><L><K><Q><T><Y><S><K><F><D><T><N><S><H><N><H><D><A><L><L><K><N><Y><G><L><L><H><C><F><R><K><D><M><D><K><V><E><T><F><L><R><M><V><Q><C><R><S><V><E><G><S><C><G><F> | May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.<BOP> | Q14406 |
Q9NQS5 | GPR84_HUMAN | Inflammation-related G-protein coupled receptor EX33 | Homo | <M><W><N><S><S><D><A><N><F><S><C><Y><H><E><S><V><L><G><Y><R><Y><V><A><V><S><W><G><V><V><V><A><V><T><G><T><V><G><N><V><L><T><L><L><A><L><A><I><Q><P><K><L><R><T><R><F><N><L><L><I><A><N><L><T><L><A><D><L><L><Y><C><T><L><L><Q><P><F><S><V><D><T><Y><L><H><L><H><W><R><T><G><A><T><F><C><R><V><F><G><L><L><L><F><A><S><N><S><V><S><I><L><T><L><C><L><I><A><L><G><R><Y><L><L><I><A><H><P><K><L><F><P><Q><V><F><S><A><K><G><I><V><L><A><L><V><S><T><W><V><V><G><V><A><S><F><A><P><L><W><P><I><Y><I><L><V><P><V><V><C><T><C><S><F><D><R><I><R><G><R><P><Y><T><T><I><L><M><G><I><Y><F><V><L><G><L><S><S><V><G><I><F><Y><C><L><I><H><R><Q><V><K><R><A><A><Q><A><L><D><Q><Y><K><L><R><Q><A><S><I><H><S><N><H><V><A><R><T><D><E><A><M><P><G><R><F><Q><E><L><D><S><R><L><A><S><G><G><P><S><E><G><I><S><S><E><P><V><S><A><A><T><T><Q><T><L><E><G><D><S><S><E><V><G><D><Q><I><N><S><K><R><A><K><Q><M><A><E><K><S><P><P><E><A><S><A><K><A><Q><P><I><K><G><A><R><R><A><P><D><S><S><S><E><F><G><K><V><T><R><M><C><F><A><V><F><L><C><F><A><L><S><Y><I><P><F><L><L><L><N><I><L><D><A><R><V><Q><A><P><R><V><V><H><M><L><A><A><N><L><T><W><L><N><G><C><I><N><P><V><L><Y><A><A><M><N><R><Q><F><R><Q><A><Y><G><S><I><L><K><R><G><P><R><S><F><H><R><L><H> | Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.<BOP> | Q9NQS5 |
Q15973 | ZN124_HUMAN | Zinc finger protein HZF-16 | Homo | <M><S><G><H><P><G><S><W><E><M><N><S><V><A><F><E><D><V><A><V><N><F><T><Q><E><E><W><A><L><L><D><P><S><Q><K><N><L><Y><R><D><V><M><Q><E><T><F><R><N><L><A><S><I><G><N><K><G><E><D><Q><S><I><E><D><Q><Y><K><N><S><S><R><N><L><R><H><I><I><S><H><S><G><N><N><P><Y><G><C><E><E><C><G><K><K><P><C><T><C><K><Q><C><Q><K><T><S><L><S><V><T><R><V><H><R><D><T><V><M><H><T><G><N><G><H><Y><G><C><T><I><C><E><K><V><F><N><I><P><S><S><F><Q><I><H><Q><R><N><H><T><G><E><K><P><Y><E><C><M><E><C><G><K><A><L><G><F><S><R><S><L><N><R><H><K><R><I><H><T><G><E><K><R><Y><E><C><K><Q><C><G><K><A><F><S><R><S><S><H><L><R><D><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><H><C><G><K><A><F><R><Y><S><N><C><L><H><Y><H><E><R><T><H><T><G><E><K><P><Y><V><C><M><E><C><G><K><A><F><S><C><L><S><S><L><Q><G><H><I><K><A><H><A><G><E><E><P><Y><P><C><K><Q><C><G><K><A><F><R><Y><A><S><S><L><Q><K><H><E><K><T><H><I><A><Q><K><P><Y><V><C><N><N><C><G><K><G><F><R><C><S><S><S><L><R><D><H><E><R><T><H><T><G><E><K><P><Y><E><C><Q><K><C><G><K><A><F><S><R><A><S><T><L><W><K><H><K><K><T><H><T><G><E><K><P><Y><K><C><K><K><M> | May be involved in transcriptional regulation.<BOP> | Q15973 |
O95639 | CPSF4_HUMAN | No arches homolog | Homo | <M><Q><E><I><I><A><S><V><D><H><I><K><F><D><L><E><I><A><V><E><Q><Q><L><G><A><Q><P><L><P><F><P><G><M><D><K><S><G><A><A><V><C><E><F><F><L><K><A><A><C><G><K><G><G><M><C><P><F><R><H><I><S><G><E><K><T><V><V><C><K><H><W><L><R><G><L><C><K><K><G><D><Q><C><E><F><L><H><E><Y><D><M><T><K><M><P><E><C><Y><F><Y><S><K><F><G><E><C><S><N><K><E><C><P><F><L><H><I><D><P><E><S><K><I><K><D><C><P><W><Y><D><R><G><F><C><K><H><G><P><L><C><R><H><R><H><T><R><R><V><I><C><V><N><Y><L><V><G><F><C><P><E><G><P><S><C><K><F><M><H><P><R><F><E><L><P><M><G><T><T><E><Q><P><P><L><P><Q><Q><T><Q><P><P><A><K><Q><S><N><N><P><P><L><Q><R><S><S><S><L><I><Q><L><T><S><Q><N><S><S><P><N><Q><Q><R><T><P><Q><V><I><G><V><M><Q><S><Q><N><S><S><A><G><N><R><G><P><R><P><L><E><Q><V><T><C><Y><K><C><G><E><K><G><H><Y><A><N><R><C><T><K><G><H><L><A><F><L><S><G><Q> | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).<BOP> | O95639 |
Q86Y82 | STX12_HUMAN | Syntaxin-12 | Homo | <M><S><Y><G><P><L><D><M><Y><R><N><P><G><P><S><G><P><Q><L><R><D><F><S><S><I><I><Q><T><C><S><G><N><I><Q><R><I><S><Q><A><T><A><Q><I><K><N><L><M><S><Q><L><G><T><K><Q><D><S><S><K><L><Q><E><N><L><Q><Q><L><Q><H><S><T><N><Q><L><A><K><E><T><N><E><L><L><K><E><L><G><S><L><P><L><P><L><S><T><S><E><Q><R><Q><Q><R><L><Q><K><E><R><L><M><N><D><F><S><A><A><L><N><N><F><Q><A><V><Q><R><R><V><S><E><K><E><K><E><S><I><A><R><A><R><A><G><S><R><L><S><A><E><E><R><Q><R><E><E><Q><L><V><S><F><D><S><H><E><E><W><N><Q><M><Q><S><Q><E><D><E><V><A><I><T><E><Q><D><L><E><L><I><K><E><R><E><T><A><I><R><Q><L><E><A><D><I><L><D><V><N><Q><I><F><K><D><L><A><M><M><I><H><D><Q><G><D><L><I><D><S><I><E><A><N><V><E><S><S><E><V><H><V><E><R><A><T><E><Q><L><Q><R><A><A><Y><Y><Q><K><K><S><R><K><K><M><C><I><L><V><L><V><L><S><V><I><I><L><I><L><G><L><I><I><W><L><V><Y><K><T><K> | SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.<BOP> | Q86Y82 |
O00422 | SAP18_HUMAN | Sin3-associated polypeptide p18 | Homo | <M><A><V><E><S><R><V><T><Q><E><E><I><K><K><E><P><E><K><P><I><D><R><E><K><T><C><P><L><L><L><R><V><F><T><T><N><N><G><R><H><H><R><M><D><E><F><S><R><G><N><V><P><S><S><E><L><Q><I><Y><T><W><M><D><A><T><L><K><E><L><T><S><L><V><K><E><V><Y><P><E><A><R><K><K><G><T><H><F><N><F><A><I><V><F><T><D><V><K><R><P><G><Y><R><V><K><E><I><G><S><T><M><S><G><R><K><G><T><D><D><S><M><T><L><Q><S><Q><K><F><Q><I><G><D><Y><L><D><I><A><I><T><P><P><N><R><A><P><P><P><S><G><R><M><R><P><Y> | Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.<BOP> | O00422 |
Q8N4Y2 | EFC4A_HUMAN | Calcium release-activated channel regulator 2B | Homo | <M><A><S><P><G><K><P><G><A><D><E><A><Q><E><E><E><G><E><L><E><G><G><S><A><G><P><R><A><A><I><L><E><Q><A><E><E><L><F><L><L><C><D><K><E><A><K><G><F><I><T><K><H><D><L><Q><G><L><Q><S><D><L><P><L><T><P><E><Q><L><E><A><V><F><E><S><L><D><R><A><H><T><G><F><L><T><A><R><E><F><C><L><G><L><G><M><F><V><G><V><A><S><A><Q><G><A><N><P><C><R><T><P><E><E><T><F><E><S><G><G><L><D><V><Q><G><T><A><G><S><L><D><E><E><E><E><E><E><E><R><F><H><T><V><L><E><Q><L><G><V><A><P><V><L><G><K><Q><R><A><V><R><T><L><W><A><R><L><Q><R><E><R><P><E><L><L><G><S><F><E><D><V><L><I><R><A><S><A><C><L><E><E><A><A><R><E><R><D><G><L><E><Q><A><L><R><R><R><E><S><E><H><E><R><E><V><R><A><L><Y><E><E><T><E><Q><L><R><E><Q><S><R><R><P><P><S><Q><N><F><A><R><G><E><R><R><S><R><L><E><L><E><L><Q><S><R><E><Q><D><L><E><R><A><G><L><R><Q><R><E><L><E><Q><Q><L><H><A><Q><A><A><E><H><L><E><A><Q><A><Q><N><S><Q><L><W><R><A><H><E><A><L><R><T><Q><L><E><G><A><Q><E><Q><I><R><R><L><E><S><E><A><R><G><R><Q><E><Q><T><Q><R><D><V><V><A><V><S><R><N><M><Q><K><E><K><V><S><L><L><R><Q><L><E><L><L><R><E><L><N><T><R><L><R><D><D><R><D><A><C><E><A><R><R><A><G><S><S><C><R><K><A><L><T><T><A><R><L><P><G><P><T><C><C><C><C><C><C><W><A><R><P><P><R><R><G><S><G><H><L><P><S><A><R> | Plays a role in store-operated Ca(2+) entry (SOCE).<BOP> | Q8N4Y2 |
O14595 | CTDS2_HUMAN | Small CTD phosphatase 2 | Homo | <M><E><H><G><S><I><I><T><Q><A><R><R><E><D><A><L><V><L><T><K><Q><G><L><V><S><K><S><S><P><K><K><P><R><G><R><N><I><F><K><A><L><F><C><C><F><R><A><Q><H><V><G><Q><S><S><S><S><T><E><L><A><A><Y><K><E><E><A><N><T><I><A><K><S><D><L><L><Q><C><L><Q><Y><Q><F><Y><Q><I><P><G><T><C><L><L><P><E><V><T><E><E><D><Q><G><R><I><C><V><V><I><D><L><D><E><T><L><V><H><S><S><F><K><P><I><N><N><A><D><F><I><V><P><I><E><I><E><G><T><T><H><Q><V><Y><V><L><K><R><P><Y><V><D><E><F><L><R><R><M><G><E><L><F><E><C><V><L><F><T><A><S><L><A><K><Y><A><D><P><V><T><D><L><L><D><R><C><G><V><F><R><A><R><L><F><R><E><S><C><V><F><H><Q><G><C><Y><V><K><D><L><S><R><L><G><R><D><L><R><K><T><L><I><L><D><N><S><P><A><S><Y><I><F><H><P><E><N><A><V><P><V><Q><S><W><F><D><D><M><A><D><T><E><L><L><N><L><I><P><I><F><E><E><L><S><G><A><E><D><V><Y><T><S><L><G><Q><L><R><A><P> | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.<BOP> | O14595 |
P10635 | CP2D6_HUMAN | Debrisoquine 4-hydroxylase | Homo | <M><G><L><E><A><L><V><P><L><A><V><I><V><A><I><F><L><L><L><V><D><L><M><H><R><R><Q><R><W><A><A><R><Y><P><P><G><P><L><P><L><P><G><L><G><N><L><L><H><V><D><F><Q><N><T><P><Y><C><F><D><Q><L><R><R><R><F><G><D><V><F><S><L><Q><L><A><W><T><P><V><V><V><L><N><G><L><A><A><V><R><E><A><L><V><T><H><G><E><D><T><A><D><R><P><P><V><P><I><T><Q><I><L><G><F><G><P><R><S><Q><G><V><F><L><A><R><Y><G><P><A><W><R><E><Q><R><R><F><S><V><S><T><L><R><N><L><G><L><G><K><K><S><L><E><Q><W><V><T><E><E><A><A><C><L><C><A><A><F><A><N><H><S><G><R><P><F><R><P><N><G><L><L><D><K><A><V><S><N><V><I><A><S><L><T><C><G><R><R><F><E><Y><D><D><P><R><F><L><R><L><L><D><L><A><Q><E><G><L><K><E><E><S><G><F><L><R><E><V><L><N><A><V><P><V><L><L><H><I><P><A><L><A><G><K><V><L><R><F><Q><K><A><F><L><T><Q><L><D><E><L><L><T><E><H><R><M><T><W><D><P><A><Q><P><P><R><D><L><T><E><A><F><L><A><E><M><E><K><A><K><G><N><P><E><S><S><F><N><D><E><N><L><R><I><V><V><A><D><L><F><S><A><G><M><V><T><T><S><T><T><L><A><W><G><L><L><L><M><I><L><H><P><D><V><Q><R><R><V><Q><Q><E><I><D><D><V><I><G><Q><V><R><R><P><E><M><G><D><Q><A><H><M><P><Y><T><T><A><V><I><H><E><V><Q><R><F><G><D><I><V><P><L><G><V><T><H><M><T><S><R><D><I><E><V><Q><G><F><R><I><P><K><G><T><T><L><I><T><N><L><S><S><V><L><K><D><E><A><V><W><E><K><P><F><R><F><H><P><E><H><F><L><D><A><Q><G><H><F><V><K><P><E><A><F><L><P><F><S><A><G><R><R><A><C><L><G><E><P><L><A><R><M><E><L><F><L><F><F><T><S><L><L><Q><H><F><S><F><S><V><P><T><G><Q><P><R><P><S><H><H><G><V><F><A><F><L><V><S><P><S><P><Y><E><L><C><A><V><P><R> | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) . Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling . Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis . Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a | P10635 |
Q8TDC0 | MYOZ3_HUMAN | FATZ-related protein 3 | Homo | <M><I><P><K><E><Q><K><G><P><V><M><A><A><M><G><D><L><T><E><P><V><P><T><L><D><L><G><K><K><L><S><V><P><Q><D><L><M><M><E><E><L><S><L><R><N><N><R><G><S><L><L><F><Q><K><R><Q><R><R><V><Q><K><F><T><F><E><L><A><A><S><Q><R><A><M><L><A><G><S><A><R><R><K><V><T><G><T><A><E><S><G><T><V><A><N><A><N><G><P><E><G><P><N><Y><R><S><E><L><H><I><F><P><A><S><P><G><A><S><L><G><G><P><E><G><A><H><P><A><A><A><P><A><G><C><V><P><S><P><S><A><L><A><P><G><Y><A><E><P><L><K><G><V><P><P><E><K><F><N><H><T><A><I><S><K><G><Y><R><C><P><W><Q><E><F><V><S><Y><R><D><Y><Q><S><D><G><R><S><H><T><P><S><P><N><D><Y><R><N><F><N><K><T><P><V><P><F><G><G><P><L><V><G><G><T><F><P><R><P><G><T><P><F><I><P><E><P><L><S><G><L><E><L><L><R><L><R><P><S><F><N><R><V><A><Q><G><W><V><R><N><L><P><E><S><E><E><L> | Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.<BOP> | Q8TDC0 |
Q8N9V6 | ANR53_HUMAN | Ankyrin repeat domain-containing protein 53 | Homo | <M><A><S><A><G><S><T><A><R><R><A><G><S><G><S><W><H><S><E><R><G><E><G><R><G><A><R><P><Q><P><T><P><S><G><S><M><Q><Q><A><N><K><V><S><L><K><A><T><W><T><D><A><E><S><K><Q><P><S><Q><P><L><P><D><L><A><D><H><L><S><A><Q><A><T><A><L><A><R><P><R><R><P><A><S><L><T><P><P><R><A><D><P><S><P><S><K><E><S><D><Q><T><A><I><D><Q><T><A><I><G><S><Y><Y><Q><L><F><A><A><A><V><G><N><V><E><W><L><R><F><C><L><N><Q><S><L><R><E><I><P><T><D><D><K><G><F><T><A><I><H><F><A><A><Q><W><G><K><L><A><C><L><Q><V><L><V><E><E><Y><K><F><P><V><D><L><L><T><N><N><S><Q><T><P><L><H><L><V><I><H><R><D><N><T><T><V><A><L><P><C><I><Y><Y><L><L><E><K><G><A><D><L><N><A><Q><T><C><N><G><S><T><P><L><H><L><A><A><R><D><G><L><L><D><C><V><K><V><L><V><Q><S><G><A><N><V><H><A><Q><D><A><M><G><Y><K><P><I><D><F><C><K><I><W><N><H><R><A><C><A><R><F><L><K><D><A><M><W><K><K><D><K><K><D><F><A><R><E><M><T><K><M><K><M><F><K><S><Q><L><T><L><M><E><H><N><Y><L><I><E><Y><Q><K><E><H><K><I><L><R><E><A><A><I><R><K><W><L><H><G><K><L><H><P><G><H><S><L><V><S><N><T><K><Q><A><R><A><T><A><L><S><K><T><P><E><Q><R><E><S><Q><R><S><R><S><F><H><P><S><V><D><A><R><L><Q><C><I><P><Q><P><T><E><M><P><K><P><I><Y><R><K><P><T><V><K><R><P><T><M><W><N><V><S><N><N><P><A><R><P><P><T><T><Q><I><S><H><S><Q><G><I><R><L><G><V><H><P><D><P><T><P><E><H><D><F><S><S><F><L><E><V><R><P><D><G><H><G><G><A><R><L><H><T><V><D><G><H><W><V><A><P><V><P><R><L><P><F><E><V><L><L><R><M><L><Y><P><R><V><W><P><Y><R><M><K><V><P><Q><G><F><Y><P><I><S><M><R><E><V><P><R><K><R><H><L><G><D><N><T><F><W><T><D><T><L><A><M><N><L><R><D><T><F><D><E><A><F><L><A><A><V><R><S><H><Q><G><L><P><T><L><P><S><P><Q><T><N><P> | Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.<BOP> | Q8N9V6 |
P35212 | CXA4_HUMAN | Connexin-37 | Homo | <M><G><D><W><G><F><L><E><K><L><L><D><Q><V><Q><E><H><S><T><V><V><G><K><I><W><L><T><V><L><F><I><F><R><I><L><I><L><G><L><A><G><E><S><V><W><G><D><E><Q><S><D><F><E><C><N><T><A><Q><P><G><C><T><N><V><C><Y><D><Q><A><F><P><I><S><H><I><R><Y><W><V><L><Q><F><L><F><V><S><T><P><T><L><V><Y><L><G><H><V><I><Y><L><S><R><R><E><E><R><L><R><Q><K><E><G><E><L><R><A><L><P><A><K><D><P><Q><V><E><R><A><L><A><A><V><E><R><Q><M><A><K><I><S><V><A><E><D><G><R><L><R><I><R><G><A><L><M><G><T><Y><V><A><S><V><L><C><K><S><V><L><E><A><G><F><L><Y><G><Q><W><R><L><Y><G><W><T><M><E><P><V><F><V><C><Q><R><A><P><C><P><Y><L><V><D><C><F><V><S><R><P><T><E><K><T><I><F><I><I><F><M><L><V><V><G><L><I><S><L><V><L><N><L><L><E><L><V><H><L><L><C><R><C><L><S><R><G><M><R><A><R><Q><G><Q><D><A><P><P><T><Q><G><T><S><S><D><P><Y><T><D><Q><V><F><F><Y><L><P><V><G><Q><G><P><S><S><P><P><C><P><T><Y><N><G><L><S><S><S><E><Q><N><W><A><N><L><T><T><E><E><R><L><A><S><S><R><P><P><L><F><L><D><P><P><P><Q><N><G><Q><K><P><P><S><R><P><S><S><S><A><S><K><K><Q><Y><V> | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.<BOP> | P35212 |
P59817 | Z280A_HUMAN | Zinc finger protein 636 | Homo | <M><G><D><I><F><L><C><K><K><V><E><S><P><K><K><N><L><R><E><S><K><Q><R><E><E><D><D><E><D><P><D><L><I><Y><V><G><V><E><H><V><H><R><D><A><E><V><L><F><V><G><M><I><S><N><S><K><P><V><V><S><N><I><L><N><R><V><T><P><G><S><N><S><R><R><K><K><G><H><F><R><Q><Y><P><A><H><V><S><Q><P><A><N><H><V><T><S><M><A><K><A><I><M><P><V><S><L><S><E><G><R><S><T><D><S><P><V><T><M><K><S><S><S><E><P><G><Y><K><M><S><S><P><Q><V><V><S><P><S><S><S><D><S><L><P><P><G><T><Q><C><L><V><G><A><M><V><S><G><G><G><R><N><E><S><S><P><D><S><K><R><L><S><T><S><D><I><N><S><R><D><S><K><R><V><K><L><R><D><G><I><P><G><V><P><S><L><A><V><V><P><S><D><M><S><S><T><I><S><T><N><T><P><S><Q><G><I><C><N><S><S><N><H><V><Q><N><G><V><T><F><P><W><P><D><A><N><G><K><A><H><F><N><L><T><D><P><E><R><A><S><E><S><A><L><A><M><T><D><I><S><S><L><A><S><Q><N><K><T><F><D><P><K><K><E><N><P><I><V><L><L><S><D><F><Y><Y><G><Q><H><K><G><D><G><Q><P><E><Q><K><T><H><T><T><F><K><C><L><S><C><V><K><V><L><K><N><I><K><F><M><N><H><M><K><H><H><L><E><F><E><K><Q><R><N><D><S><W><E><D><H><T><T><C><Q><H><C><H><R><Q><F><P><T><P><F><Q><L><Q><C><H><I><D><S><V><H><I><A><M><G><P><S><A><V><C><K><I><C><E><L><S><F><E><T><D><Q><V><L><L><Q><H><M><K><D><H><H><K><P><G><E><M><P><Y><V><C><Q><V><C><H><Y><R><S><S><V><F><A><D><V><E><T><H><F><R><T><C><H><E><N><T><K><N><L><L><C><L><F><C><L><K><L><F><K><T><A><I><P><Y><M><N><H><C><W><R><H><S><R><R><R><V><L><Q><C><S><K><C><R><L><Q><F><L><T><L><K><E><E><I><E><H><K><T><K><D><H><Q><T><F><K><K><P><E><Q><L><Q><G><L><P><S><E><T><K><V><I><I><Q><T><S><V><Q><P><G><S><S><G><M><A><S><V><I><V><S><N><T><D><P><Q><S><S><P><V><K><T><K><K><K><T><A><M><N><T><R><D><S><R><L><P><C><S><K><D><S><S> | May function as a transcription factor.<BOP> | P59817 |
Q8NHV9 | RHXF1_HUMAN | Paired-like homeobox protein PEPP-1 | Homo | <M><A><R><S><L><V><H><D><T><V><F><Y><C><L><S><V><Y><Q><V><K><I><S><P><T><P><Q><L><G><A><A><S><S><A><E><G><H><V><G><Q><G><A><P><G><L><M><G><N><M><N><P><E><G><G><V><N><H><E><N><G><M><N><R><D><G><G><M><I><P><E><G><G><G><G><N><Q><E><P><R><Q><Q><P><Q><P><P><P><E><E><P><A><Q><A><A><M><E><G><P><Q><P><E><N><M><Q><P><R><T><R><R><T><K><F><T><L><L><Q><V><E><E><L><E><S><V><F><R><H><T><Q><Y><P><D><V><P><T><R><R><E><L><A><E><N><L><G><V><T><E><D><K><V><R><V><W><F><K><N><K><R><A><R><C><R><R><H><Q><R><E><L><M><L><A><N><E><L><R><A><D><P><D><D><C><V><Y><I><V><V><D> | Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.<BOP> | Q8NHV9 |
Q9NYX4 | CALY_HUMAN | Neuron-specific vesicular protein calcyon | Homo | <M><V><K><L><G><C><S><F><S><G><K><P><G><K><D><P><G><D><Q><D><G><A><A><M><D><S><V><P><L><I><S><P><L><D><I><S><Q><L><Q><P><P><L><P><D><Q><V><V><I><K><T><Q><T><E><Y><Q><L><S><S><P><D><Q><Q><N><F><P><D><L><E><G><Q><R><L><N><C><S><H><P><E><E><G><R><R><L><P><T><A><R><M><I><A><F><A><M><A><L><L><G><C><V><L><I><M><Y><K><A><I><W><Y><D><Q><F><T><C><P><D><G><F><L><L><R><H><K><I><C><T><P><L><T><L><E><M><Y><Y><T><E><M><D><P><E><R><H><R><S><I><L><A><A><I><G><A><Y><P><L><S><R><K><H><G><T><E><T><P><A><A><W><G><D><G><Y><R><A><A><K><E><E><R><K><G><P><T><Q><A><G><A><A><A><A><A><T><E><P><P><G><K><P><S><A><K><A><E><K><E><A><A><R><K><A><A><G><S><A><A><P><P><P><A><Q> | Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.<BOP> | Q9NYX4 |
O95372 | LYPA2_HUMAN | Palmitoyl-protein hydrolase | Homo | <M><C><G><N><T><M><S><V><P><L><L><T><D><A><A><T><V><S><G><A><E><R><E><T><A><A><V><I><F><L><H><G><L><G><D><T><G><H><S><W><A><D><A><L><S><T><I><R><L><P><H><V><K><Y><I><C><P><H><A><P><R><I><P><V><T><L><N><M><K><M><V><M><P><S><W><F><D><L><M><G><L><S><P><D><A><P><E><D><E><A><G><I><K><K><A><A><E><N><I><K><A><L><I><E><H><E><M><K><N><G><I><P><A><N><R><I><V><L><G><G><F><S><Q><G><G><A><L><S><L><Y><T><A><L><T><C><P><H><P><L><A><G><I><V><A><L><S><C><W><L><P><L><H><R><A><F><P><Q><A><A><N><G><S><A><K><D><L><A><I><L><Q><C><H><G><E><L><D><P><M><V><P><V><R><F><G><A><L><T><A><E><K><L><R><S><V><V><T><P><A><R><V><Q><F><K><T><Y><P><G><V><M><H><S><S><C><P><Q><E><M><A><A><V><K><E><F><L><E><K><L><L><P><P><V> | Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS . Deacylates GAP43 . Mediates depalmitoylation of ZDHHC6 . Has lysophospholipase activity . Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) . Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide .<BOP> | O95372 |
P08833 | IBP1_HUMAN | Placental protein 12 | Homo | <M><S><E><V><P><V><A><R><V><W><L><V><L><L><L><L><T><V><Q><V><G><V><T><A><G><A><P><W><Q><C><A><P><C><S><A><E><K><L><A><L><C><P><P><V><S><A><S><C><S><E><V><T><R><S><A><G><C><G><C><C><P><M><C><A><L><P><L><G><A><A><C><G><V><A><T><A><R><C><A><R><G><L><S><C><R><A><L><P><G><E><Q><Q><P><L><H><A><L><T><R><G><Q><G><A><C><V><Q><E><S><D><A><S><A><P><H><A><A><E><A><G><S><P><E><S><P><E><S><T><E><I><T><E><E><E><L><L><D><N><F><H><L><M><A><P><S><E><E><D><H><S><I><L><W><D><A><I><S><T><Y><D><G><S><K><A><L><H><V><T><N><I><K><K><W><K><E><P><C><R><I><E><L><Y><R><V><V><E><S><L><A><K><A><Q><E><T><S><G><E><E><I><S><K><F><Y><L><P><N><C><N><K><N><G><F><Y><H><S><R><Q><C><E><T><S><M><D><G><E><A><G><L><C><W><C><V><Y><P><W><N><G><K><R><I><P><G><S><P><E><I><R><G><D><P><N><C><Q><I><Y><F><N><V><Q><N> | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.<BOP> | P08833 |
O95837 | GNA14_HUMAN | Guanine nucleotide-binding protein subunit alpha-14 | Homo | <M><A><G><C><C><C><L><S><A><E><E><K><E><S><Q><R><I><S><A><E><I><E><R><Q><L><R><R><D><K><K><D><A><R><R><E><L><K><L><L><L><L><G><T><G><E><S><G><K><S><T><F><I><K><Q><M><R><I><I><H><G><S><G><Y><S><D><E><D><R><K><G><F><T><K><L><V><Y><Q><N><I><F><T><A><M><Q><A><M><I><R><A><M><D><T><L><R><I><Q><Y><V><C><E><Q><N><K><E><N><A><Q><I><I><R><E><V><E><V><D><K><V><S><M><L><S><R><E><Q><V><E><A><I><K><Q><L><W><Q><D><P><G><I><Q><E><C><Y><D><R><R><R><E><Y><Q><L><S><D><S><A><K><Y><Y><L><T><D><I><D><R><I><A><T><P><S><F><V><P><T><Q><Q><D><V><L><R><V><R><V><P><T><T><G><I><I><E><Y><P><F><D><L><E><N><I><I><F><R><M><V><D><V><G><G><Q><R><S><E><R><R><K><W><I><H><C><F><E><S><V><T><S><I><I><F><L><V><A><L><S><E><Y><D><Q><V><L><A><E><C><D><N><E><N><R><M><E><E><S><K><A><L><F><K><T><I><I><T><Y><P><W><F><L><N><S><S><V><I><L><F><L><N><K><K><D><L><L><E><E><K><I><M><Y><S><H><L><I><S><Y><F><P><E><Y><T><G><P><K><Q><D><V><R><A><A><R><D><F><I><L><K><L><Y><Q><D><Q><N><P><D><K><E><K><V><I><Y><S><H><F><T><C><A><T><D><T><D><N><I><R><F><V><F><A><A><V><K><D><T><I><L><Q><L><N><L><R><E><F><N><L><V> | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.<BOP> | O95837 |
Q99943 | PLCA_HUMAN | Protein G15 | Homo | <M><D><L><W><P><G><A><W><M><L><L><L><L><L><F><L><L><L><L><F><L><L><P><T><L><W><F><C><S><P><S><A><K><Y><F><F><K><M><A><F><Y><N><G><W><I><L><F><L><A><V><L><A><I><P><V><C><A><V><R><G><R><N><V><E><N><M><K><I><L><R><L><M><L><L><H><I><K><Y><L><Y><G><I><R><V><E><V><R><G><A><H><H><F><P><P><S><Q><P><Y><V><V><V><S><N><H><Q><S><S><L><D><L><L><G><M><M><E><V><L><P><G><R><C><V><P><I><A><K><R><E><L><L><W><A><G><S><A><G><L><A><C><W><L><A><G><V><I><F><I><D><R><K><R><T><G><D><A><I><S><V><M><S><E><V><A><Q><T><L><L><T><Q><D><V><R><V><W><V><F><P><E><G><T><R><N><H><N><G><S><M><L><P><F><K><R><G><A><F><H><L><A><V><Q><A><Q><V><P><I><V><P><I><V><M><S><S><Y><Q><D><F><Y><C><K><K><E><R><R><F><T><S><G><Q><C><Q><V><R><V><L><P><P><V><P><T><E><G><L><T><P><D><D><V><P><A><L><A><D><R><V><R><H><S><M><L><T><V><F><R><E><I><S><T><D><G><R><G><G><G><D><Y><L><K><K><P><G><G><G><G> | Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.<BOP> | Q99943 |
O00214 | LEG8_HUMAN | Prostate carcinoma tumor antigen 1 | Homo | <M><M><L><S><L><N><N><L><Q><N><I><I><Y><N><P><V><I><P><F><V><G><T><I><P><D><Q><L><D><P><G><T><L><I><V><I><R><G><H><V><P><S><D><A><D><R><F><Q><V><D><L><Q><N><G><S><S><M><K><P><R><A><D><V><A><F><H><F><N><P><R><F><K><R><A><G><C><I><V><C><N><T><L><I><N><E><K><W><G><R><E><E><I><T><Y><D><T><P><F><K><R><E><K><S><F><E><I><V><I><M><V><L><K><D><K><F><Q><V><A><V><N><G><K><H><T><L><L><Y><G><H><R><I><G><P><E><K><I><D><T><L><G><I><Y><G><K><V><N><I><H><S><I><G><F><S><F><S><S><D><L><Q><S><T><Q><A><S><S><L><E><L><T><E><I><S><R><E><N><V><P><K><S><G><T><P><Q><L><R><L><P><F><A><A><R><L><N><T><P><M><G><P><G><R><T><V><V><V><K><G><E><V><N><A><N><A><K><S><F><N><V><D><L><L><A><G><K><S><K><D><I><A><L><H><L><N><P><R><L><N><I><K><A><F><V><R><N><S><F><L><Q><E><S><W><G><E><E><E><R><N><I><T><S><F><P><F><S><P><G><M><Y><F><E><M><I><I><Y><C><D><V><R><E><F><K><V><A><V><N><G><V><H><S><L><E><Y><K><H><R><F><K><E><L><S><S><I><D><T><L><E><I><N><G><D><I><H><L><L><E><V><R><S><W> | Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy . Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture . Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 . Required to restrict infection of bacterial invasion such as S.typhimurium . Also required to restrict infection of Picornaviridae viruses . Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans .<BOP> | O00214 |
O43812 | DUX1_HUMAN | Double homeobox protein 1 | Homo | <M><A><L><L><T><A><L><D><D><T><L><P><E><E><A><Q><G><P><G><R><R><M><I><L><L><S><T><P><S><Q><S><D><A><L><R><A><C><F><E><R><N><L><Y><P><G><I><A><T><K><E><E><L><A><Q><G><I><D><I><P><E><P><R><V><Q><I><W><F><Q><N><E><R><S><C><Q><L><R><Q><H><R><R><Q><S><R><P><W><P><G><R><R><D><P><Q><K><G><R><R><K><R><T><A><I><T><G><S><Q><T><A><L><L><L><R><A><F><E><K><D><R><F><P><G><I><A><A><R><E><E><L><A><R><E><T><G><L><P><E><S><R><I><Q><I><W><F><Q><N><R><R><A><R><H><R><G><Q><S><G><R><A><P><T><Q><A><S><I><R><C><N><A><A><P><I><G> | Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'.<BOP> | O43812 |
P27352 | IF_HUMAN | Intrinsic factor | Homo | <M><A><W><F><A><L><Y><L><L><S><L><L><W><A><T><A><G><T><S><T><Q><T><Q><S><S><C><S><V><P><S><A><Q><E><P><L><V><N><G><I><Q><V><L><M><E><N><S><V><T><S><S><A><Y><P><N><P><S><I><L><I><A><M><N><L><A><G><A><Y><N><L><K><A><Q><K><L><L><T><Y><Q><L><M><S><S><D><N><N><D><L><T><I><G><Q><L><G><L><T><I><M><A><L><T><S><S><C><R><D><P><G><D><K><V><S><I><L><Q><R><Q><M><E><N><W><A><P><S><S><P><N><A><E><A><S><A><F><Y><G><P><S><L><A><I><L><A><L><C><Q><K><N><S><E><A><T><L><P><I><A><V><R><F><A><K><T><L><L><A><N><S><S><P><F><N><V><D><T><G><A><M><A><T><L><A><L><T><C><M><Y><N><K><I><P><V><G><S><E><E><G><Y><R><S><L><F><G><Q><V><L><K><D><I><V><E><K><I><S><M><K><I><K><D><N><G><I><I><G><D><I><Y><S><T><G><L><A><M><Q><A><L><S><V><T><P><E><P><S><K><K><E><W><N><C><K><K><T><T><D><M><I><L><N><E><I><K><Q><G><K><F><H><N><P><M><S><I><A><Q><I><L><P><S><L><K><G><K><T><Y><L><D><V><P><Q><V><T><C><S><P><D><H><E><V><Q><P><T><L><P><S><N><P><G><P><G><P><T><S><A><S><N><I><T><V><I><Y><T><I><N><N><Q><L><R><G><V><E><L><L><F><N><E><T><I><N><V><S><V><K><S><G><S><V><L><L><V><V><L><E><E><A><Q><R><K><N><P><M><F><K><F><E><T><T><M><T><S><W><G><L><V><V><S><S><I><N><N><I><A><E><N><V><N><H><K><T><Y><W><Q><F><L><S><G><V><T><P><L><N><E><G><V><A><D><Y><I><P><F><N><H><E><H><I><T><A><N><F><T><Q><Y> | Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.<BOP> | P27352 |
P04003 | C4BPA_HUMAN | Proline-rich protein | Homo | <M><H><P><P><K><T><P><S><G><A><L><H><R><K><R><K><M><A><A><W><P><F><S><R><L><W><K><V><S><D><P><I><L><F><Q><M><T><L><I><A><A><L><L><P><A><V><L><G><N><C><G><P><P><P><T><L><S><F><A><A><P><M><D><I><T><L><T><E><T><R><F><K><T><G><T><T><L><K><Y><T><C><L><P><G><Y><V><R><S><H><S><T><Q><T><L><T><C><N><S><D><G><E><W><V><Y><N><T><F><C><I><Y><K><R><C><R><H><P><G><E><L><R><N><G><Q><V><E><I><K><T><D><L><S><F><G><S><Q><I><E><F><S><C><S><E><G><F><F><L><I><G><S><T><T><S><R><C><E><V><Q><D><R><G><V><G><W><S><H><P><L><P><Q><C><E><I><V><K><C><K><P><P><P><D><I><R><N><G><R><H><S><G><E><E><N><F><Y><A><Y><G><F><S><V><T><Y><S><C><D><P><R><F><S><L><L><G><H><A><S><I><S><C><T><V><E><N><E><T><I><G><V><W><R><P><S><P><P><T><C><E><K><I><T><C><R><K><P><D><V><S><H><G><E><M><V><S><G><F><G><P><I><Y><N><Y><K><D><T><I><V><F><K><C><Q><K><G><F><V><L><R><G><S><S><V><I><H><C><D><A><D><S><K><W><N><P><S><P><P><A><C><E><P><N><S><C><I><N><L><P><D><I><P><H><A><S><W><E><T><Y><P><R><P><T><K><E><D><V><Y><V><V><G><T><V><L><R><Y><R><C><H><P><G><Y><K><P><T><T><D><E><P><T><T><V><I><C><Q><K><N><L><R><W><T><P><Y><Q><G><C><E><A><L><C><C><P><E><P><K><L><N><N><G><E><I><T><Q><H><R><K><S><R><P><A><N><H><C><V><Y><F><Y><G><D><E><I><S><F><S><C><H><E><T><S><R><F><S><A><I><C><Q><G><D><G><T><W><S><P><R><T><P><S><C><G><D><I><C><N><F><P><P><K><I><A><H><G><H><Y><K><Q><S><S><S><Y><S><F><F><K><E><E><I><I><Y><E><C><D><K><G><Y><I><L><V><G><Q><A><K><L><S><C><S><Y><S><H><W><S><A><P><A><P><Q><C><K><A><L><C><R><K><P><E><L><V><N><G><R><L><S><V><D><K><D><Q><Y><V><E><P><E><N><V><T><I><Q><C><D><S><G><Y><G><V><V><G><P><Q><S><I><T><C><S><G><N><R><T><W><Y><P><E><V><P><K><C><E><W><E><T><P><E><G><C><E><Q><V><L><T><G><K><R><L><M><Q><C><L><P><N><P><E><D><V><K><M><A><L><E><V><Y><K><L><S><L><E><I><E><Q><L><E><L><Q><R><D><S><A><R><Q><S><T><L><D><K><E><L> | Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.<BOP> | P04003 |
Q16740 | CLPP_HUMAN | Endopeptidase Clp | Homo | <M><W><P><G><I><L><V><G><G><A><R><V><A><S><C><R><Y><P><A><L><G><P><R><L><A><A><H><F><P><A><Q><R><P><P><Q><R><T><L><Q><N><G><L><A><L><Q><R><C><L><H><A><T><A><T><R><A><L><P><L><I><P><I><V><V><E><Q><T><G><R><G><E><R><A><Y><D><I><Y><S><R><L><L><R><E><R><I><V><C><V><M><G><P><I><D><D><S><V><A><S><L><V><I><A><Q><L><L><F><L><Q><S><E><S><N><K><K><P><I><H><M><Y><I><N><S><P><G><G><V><V><T><A><G><L><A><I><Y><D><T><M><Q><Y><I><L><N><P><I><C><T><W><C><V><G><Q><A><A><S><M><G><S><L><L><L><A><A><G><T><P><G><M><R><H><S><L><P><N><S><R><I><M><I><H><Q><P><S><G><G><A><R><G><Q><A><T><D><I><A><I><Q><A><E><E><I><M><K><L><K><K><Q><L><Y><N><I><Y><A><K><H><T><K><Q><S><L><Q><V><I><E><S><A><M><E><R><D><R><Y><M><S><P><M><E><A><Q><E><F><G><I><L><D><K><V><L><V><H><P><P><Q><D><G><E><D><E><P><T><L><V><Q><K><E><P><V><E><A><A><P><A><A><E><P><V><P><A><S><T> | Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates . Cleaves PINK1 in the mitochondrion .<BOP> | Q16740 |
Q7Z6W7 | DNJB7_HUMAN | DnaJ homolog subfamily B member 7 | Homo | <M><V><D><Y><Y><E><V><L><G><L><Q><R><Y><A><S><P><E><D><I><K><K><A><Y><H><K><V><A><L><K><W><H><P><D><K><N><P><E><N><K><E><E><A><E><R><K><F><K><E><V><A><E><A><Y><E><V><L><S><N><D><E><K><R><D><I><Y><D><K><Y><G><T><E><G><L><N><G><G><G><S><H><F><D><D><E><C><E><Y><G><F><T><F><H><K><P><D><D><V><F><K><E><I><F><H><E><R><D><P><F><S><F><H><F><F><E><D><S><L><E><D><L><L><N><R><P><G><S><S><Y><G><N><R><N><R><D><A><G><Y><F><F><S><T><A><S><E><Y><P><I><F><E><K><F><S><S><Y><D><T><G><Y><T><S><Q><G><S><L><G><H><E><G><L><T><S><F><S><S><L><A><F><D><N><S><G><M><D><N><Y><I><S><V><T><T><S><D><K><I><V><N><G><R><N><I><N><T><K><K><I><I><E><S><D><Q><E><R><E><A><E><D><N><G><E><L><T><F><F><L><V><N><S><V><A><N><E><E><G><F><A><K><E><C><S><W><R><T><Q><S><F><N><N><Y><S><P><N><S><H><S><S><K><H><V><S><Q><Y><T><F><V><D><N><D><E><G><G><I><S><W><V><T><S><N><R><D><P><P><I><F><S><A><G><V><K><E><G><G><K><R><K><K><K><K><R><K><E><V><Q><K><K><S><T><K><R><N><C> | Probably acts as a co-chaperone.<BOP> | Q7Z6W7 |
Q96BI1 | S22AI_HUMAN | p45-Beckwith-Wiedemann region 1 A | Homo | <M><Q><G><A><R><A><P><R><D><Q><G><R><S><P><G><R><M><S><A><L><G><R><S><S><V><I><L><L><T><Y><V><L><A><A><T><E><L><T><C><L><F><M><Q><F><S><I><V><P><Y><L><S><R><K><L><G><L><D><S><I><A><F><G><Y><L><Q><T><T><F><G><V><L><Q><L><L><G><G><P><V><F><G><R><F><A><D><Q><R><G><A><R><A><A><L><T><L><S><F><L><A><A><L><A><L><Y><L><L><L><A><A><A><S><S><P><A><L><P><G><V><Y><L><L><F><A><S><R><L><P><G><A><L><M><H><T><L><P><A><A><Q><M><V><I><T><D><L><S><A><P><E><E><R><P><A><A><L><G><R><L><G><L><C><F><G><V><G><V><I><L><G><S><L><L><G><G><T><L><V><S><A><Y><G><I><Q><C><P><A><I><L><A><A><L><A><T><L><L><G><A><V><L><S><F><T><C><I><P><A><S><T><K><G><A><K><T><D><A><Q><A><P><L><P><G><G><P><R><A><S><V><F><D><L><K><A><I><A><S><L><L><R><L><P><D><V><P><R><I><F><L><V><K><V><A><S><N><C><P><T><G><L><F><M><V><M><F><S><I><I><S><M><D><F><F><Q><L><E><A><A><Q><A><G><Y><L><M><S><F><F><G><L><L><Q><M><V><T><Q><G><L><V><I><G><Q><L><S><S><H><F><S><E><E><V><L><L><R><A><S><V><L><V><F><I><V><V><G><L><A><M><A><W><M><S><S><V><F><H><F><C><L><L><V><P><G><L><V><F><S><L><C><T><L><N><V><V><T><D><S><M><L><I><K><A><V><S><T><S><D><T><G><T><M><L><G><L><C><A><S><V><Q><P><L><L><R><T><L><G><P><T><V><G><G><L><L><Y><R><S><F><G><V><P><V><F><G><H><V><Q><V><A><I><N><T><L><V><L><L><V><L><W><R><K><P><M><P><Q><R><K><D><K><V><R> | May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.<BOP> | Q96BI1 |
E9PQX1 | TM262_HUMAN | Transmembrane protein 262 | Homo | <M><W><L><Q><D><R><I><A><T><F><F><F><P><K><G><M><M><L><T><T><A><A><L><M><L><F><F><L><H><L><G><I><F><I><R><D><V><H><N><F><C><I><T><Y><H><Y><D><H><M><S><F><H><Y><T><V><V><L><M><F><S><Q><V><I><S><I><C><W><A><A><M><G><S><L><Y><A><E><M><T><E><N><K><Y><V><C><F><S><A><L><T><I><L><M><L><N><G><A><M><F><F><N><R><L><S><L><E><F><L><A><I><E><Y><R><E><E><H><H> | Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.<BOP> | E9PQX1 |
A0A075B6R0 | TRGV2_HUMAN | T cell receptor gamma variable 2 | Homo | <M><Q><W><A><L><A><V><L><L><A><F><L><S><P><A><S><Q><K><S><S><N><L><E><G><R><T><K><S><V><I><R><Q><T><G><S><S><A><E><I><T><C><D><L><A><E><G><S><N><G><Y><I><H><W><Y><L><H><Q><E><G><K><A><P><Q><R><L><Q><Y><Y><D><S><Y><N><S><K><V><V><L><E><S><G><V><S><P><G><K><Y><Y><T><Y><A><S><T><R><N><N><L><R><L><I><L><R><N><L><I><E><N><D><F><G><V><Y><Y><C><A><T><W><D><G> | V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair . Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells . Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential | A0A075B6R0 |
A8MXD5 | GRCR1_HUMAN | Glutaredoxin domain-containing cysteine-rich protein 1 | Homo | <M><L><K><R><E><M><K><P><E><S><D><R><P><R><K><V><R><F><R><I><A><S><S><H><S><G><R><V><L><K><E><V><Y><E><D><G><Q><P><S><G><S><L><D><S><E><C><A><S><I><C><G><I><D><G><L><G><D><S><D><G><Q><Q><N><G><H><I><E><S><E><G><D><E><N><E><N><D><Q><D><S><L><L><V><L><A><R><A><A><S><E><K><G><F><G><T><R><R><V><N><I><L><S><K><N><G><T><V><R><G><V><K><Y><K><V><S><A><G><Q><A><L><F><N><N><L><T><K><V><L><Q><Q><P><S><T><D><L><E><F><D><R><V><V><I><Y><T><T><C><L><R><V><V><R><T><T><F><E><R><C><E><L><V><R><K><I><F><Q><N><H><R><V><K><F><E><E><K><N><I><A><L><N><G><E><Y><G><K><E><L><D><E><R><C><R><R><V><S><E><A><P><S><L><P><V><V><F><I><D><G><H><Y><L><G><G><A><E><K><I><L><S><M><N><E><S><G><E><L><Q><D><I><L><T><K><I><E><R><V><Q><H><P><H><E><C><P><S><C><G><G><F><G><F><L><P><C><S><V><C><H><G><S><K><M><S><M><F><R><N><C><F><T><D><S><F><K><A><L><K><C><T><A><C><N><E><N><G><L><Q><R><C><K><N><C><A><G> | May play a role in actin filament architecture in developing stereocilia of sensory cells.<BOP> | A8MXD5 |
P50336 | PPOX_HUMAN | Protoporphyrinogen oxidase | Homo | <M><G><R><T><V><V><V><L><G><G><G><I><S><G><L><A><A><S><Y><H><L><S><R><A><P><C><P><P><K><V><V><L><V><E><S><S><E><R><L><G><G><W><I><R><S><V><R><G><P><N><G><A><I><F><E><L><G><P><R><G><I><R><P><A><G><A><L><G><A><R><T><L><L><L><V><S><E><L><G><L><D><S><E><V><L><P><V><R><G><D><H><P><A><A><Q><N><R><F><L><Y><V><G><G><A><L><H><A><L><P><T><G><L><R><G><L><L><R><P><S><P><P><F><S><K><P><L><F><W><A><G><L><R><E><L><T><K><P><R><G><K><E><P><D><E><T><V><H><S><F><A><Q><R><R><L><G><P><E><V><A><S><L><A><M><D><S><L><C><R><G><V><F><A><G><N><S><R><E><L><S><I><R><S><C><F><P><S><L><F><Q><A><E><Q><T><H><R><S><I><L><L><G><L><L><L><G><A><G><R><T><P><Q><P><D><S><A><L><I><R><Q><A><L><A><E><R><W><S><Q><W><S><L><R><G><G><L><E><M><L><P><Q><A><L><E><T><H><L><T><S><R><G><V><S><V><L><R><G><Q><P><V><C><G><L><S><L><Q><A><E><G><R><W><K><V><S><L><R><D><S><S><L><E><A><D><H><V><I><S><A><I><P><A><S><V><L><S><E><L><L><P><A><E><A><A><P><L><A><R><A><L><S><A><I><T><A><V><S><V><A><V><V><N><L><Q><Y><Q><G><A><H><L><P><V><Q><G><F><G><H><L><V><P><S><S><E><D><P><G><V><L><G><I><V><Y><D><S><V><A><F><P><E><Q><D><G><S><P><P><G><L><R><V><T><V><M><L><G><G><S><W><L><Q><T><L><E><A><S><G><C><V><L><S><Q><E><L><F><Q><Q><R><A><Q><E><A><A><A><T><Q><L><G><L><K><E><M><P><S><H><C><L><V><H><L><H><K><N><C><I><P><Q><Y><T><L><G><H><W><Q><K><L><E><S><A><R><Q><F><L><T><A><H><R><L><P><L><T><L><A><G><A><S><Y><E><G><V><A><V><N><D><C><I><E><S><G><R><Q><A><A><V><S><V><L><G><T><E><P><N><S> | Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.<BOP> | P50336 |
Q8NHG8 | ZNRF2_HUMAN | Zinc/RING finger protein 2 | Homo | <M><G><A><K><Q><S><G><P><A><A><A><N><G><R><T><R><A><Y><S><G><S><D><L><P><S><S><S><S><G><G><A><N><G><T><A><G><G><G><G><G><A><R><A><A><A><A><G><R><F><P><A><Q><V><P><S><A><H><Q><P><S><A><S><G><G><A><A><A><A><A><A><A><P><A><A><P><A><A><P><R><S><R><S><L><G><G><A><V><G><S><V><A><S><G><A><R><A><A><Q><S><P><F><S><I><P><N><S><S><S><G><P><Y><G><S><Q><D><S><V><H><S><S><P><E><D><G><G><G><G><R><D><R><P><V><G><G><S><P><G><G><P><R><L><V><I><G><S><L><P><A><H><L><S><P><H><M><F><G><G><F><K><C><P><V><C><S><K><F><V><S><S><D><E><M><D><L><H><L><V><M><C><L><T><K><P><R><I><T><Y><N><E><D><V><L><S><K><D><A><G><E><C><A><I><C><L><E><E><L><Q><Q><G><D><T><I><A><R><L><P><C><L><C><I><Y><H><K><G><C><I><D><E><W><F><E><V><N><R><S><C><P><E><H><P><S><D> | May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.<BOP> | Q8NHG8 |
O60907 | TBL1X_HUMAN | Transducin-beta-like protein 1, X-linked | Homo | <M><T><E><L><A><G><A><S><S><S><C><C><H><R><P><A><G><R><G><A><M><Q><S><V><L><H><H><F><Q><R><L><R><G><R><E><G><G><S><H><F><I><N><T><S><S><P><R><G><E><A><K><M><S><I><T><S><D><E><V><N><F><L><V><Y><R><Y><L><Q><E><S><G><F><S><H><S><A><F><T><F><G><I><E><S><H><I><S><Q><S><N><I><N><G><T><L><V><P><P><A><A><L><I><S><I><L><Q><K><G><L><Q><Y><V><E><A><E><I><S><I><N><E><D><G><T><V><F><D><G><R><P><I><E><S><L><S><L><I><D><A><V><M><P><D><V><V><Q><T><R><Q><Q><A><F><R><E><K><L><A><Q><Q><Q><A><S><A><A><A><A><A><A><A><A><T><A><A><A><T><A><A><T><T><T><S><A><G><V><S><H><Q><N><P><S><K><N><R><E><A><T><V><N><G><E><E><N><R><A><H><S><V><N><N><H><A><K><P><M><E><I><D><G><E><V><E><I><P><S><S><K><A><T><V><L><R><G><H><E><S><E><V><F><I><C><A><W><N><P><V><S><D><L><L><A><S><G><S><G><D><S><T><A><R><I><W><N><L><N><E><N><S><N><G><G><S><T><Q><L><V><L><R><H><C><I><R><E><G><G><H><D><V><P><S><N><K><D><V><T><S><L><D><W><N><T><N><G><T><L><L><A><T><G><S><Y><D><G><F><A><R><I><W><T><E><D><G><N><L><A><S><T><L><G><Q><H><K><G><P><I><F><A><L><K><W><N><R><K><G><N><Y><I><L><S><A><G><V><D><K><T><T><I><I><W><D><A><H><T><G><E><A><K><Q><Q><F><P><F><H><S><A><P><A><L><D><V><D><W><Q><N><N><T><T><F><A><S><C><S><T><D><M><C><I><H><V><C><R><L><G><C><D><R><P><V><K><T><F><Q><G><H><T><N><E><V><N><A><I><K><W><D><P><S><G><M><L><L><A><S><C><S><D><D><M><T><L><K><I><W><S><M><K><Q><E><V><C><I><H><D><L><Q><A><H><N><K><E><I><Y><T><I><K><W><S><P><T><G><P><A><T><S><N><P><N><S><N><I><M><L><A><S><A><S><F><D><S><T><V><R><L><W><D><I><E><R><G><V><C><T><H><T><L><T><K><H><Q><E><P><V><Y><S><V><A><F><S><P><D><G><K><Y><L><A><S><G><S><F><D><K><C><V><H><I><W><N><T><Q><S><G><N><L><V><H><S><Y><R><G><T><G><G><I><F><E><V><C><W><N><A><R><G><D><K><V><G><A><S><A><S><D><G><S><V><C><V><L><D><L><R><K> | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units . Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange .<BOP> | O60907 |
Q9BWX1 | PHF7_HUMAN | Testis development protein NYD-SP6 | Homo | <M><K><T><V><K><E><K><K><E><C><Q><R><L><R><K><S><A><K><T><R><R><V><T><Q><R><K><P><S><S><G><P><V><C><W><L><C><L><R><E><P><G><D><P><E><K><L><G><E><F><L><Q><K><D><N><I><S><V><H><Y><F><C><L><I><L><S><S><K><L><P><Q><R><G><Q><S><N><R><G><F><H><G><F><L><P><E><D><I><K><K><E><A><A><R><A><S><R><K><I><C><F><V><C><K><K><K><G><A><A><I><N><C><Q><K><D><Q><C><L><R><N><F><H><L><P><C><G><Q><E><R><G><C><L><S><Q><F><F><G><E><Y><K><S><F><C><D><K><H><R><P><T><Q><N><I><Q><H><G><H><V><G><E><E><S><C><I><L><C><C><E><D><L><S><Q><Q><S><V><E><N><I><Q><S><P><C><C><S><Q><A><I><Y><H><R><K><C><I><Q><K><Y><A><H><T><S><A><K><H><F><F><K><C><P><Q><C><N><N><R><K><E><F><P><Q><E><M><L><R><M><G><I><H><I><P><D><R><D><A><A><W><E><L><E><P><G><A><F><S><D><L><Y><Q><R><Y><Q><H><C><D><A><P><I><C><L><Y><E><Q><G><R><D><S><F><E><D><E><G><R><W><C><L><I><L><C><A><T><C><G><S><H><G><T><H><R><D><C><S><S><L><R><S><N><S><K><K><W><E><C><E><E><C><S><P><A><A><A><T><D><Y><I><P><E><N><S><G><D><I><P><C><C><S><S><T><F><H><P><E><E><H><F><C><R><D><N><T><L><E><E><N><P><G><L><S><W><T><D><W><P><E><P><S><L><L><E><K><P><E><S><S><R><G><R><R><S><Y><S><W><R><S><K><G><V><R><I><T><N><S><C><K><K><S><K> | May play a role in spermatogenesis.<BOP> | Q9BWX1 |
P47211 | GALR1_HUMAN | Galanin receptor type 1 | Homo | <M><E><L><A><V><G><N><L><S><E><G><N><A><S><W><P><E><P><P><A><P><E><P><G><P><L><F><G><I><G><V><E><N><F><V><T><L><V><V><F><G><L><I><F><A><L><G><V><L><G><N><S><L><V><I><T><V><L><A><R><S><K><P><G><K><P><R><S><T><T><N><L><F><I><L><N><L><S><I><A><D><L><A><Y><L><L><F><C><I><P><F><Q><A><T><V><Y><A><L><P><T><W><V><L><G><A><F><I><C><K><F><I><H><Y><F><F><T><V><S><M><L><V><S><I><F><T><L><A><A><M><S><V><D><R><Y><V><A><I><V><H><S><R><R><S><S><S><L><R><V><S><R><N><A><L><L><G><V><G><C><I><W><A><L><S><I><A><M><A><S><P><V><A><Y><H><Q><G><L><F><H><P><R><A><S><N><Q><T><F><C><W><E><Q><W><P><D><P><R><H><K><K><A><Y><V><V><C><T><F><V><F><G><Y><L><L><P><L><L><L><I><C><F><C><Y><A><K><V><L><N><H><L><H><K><K><L><K><N><M><S><K><K><S><E><A><S><K><K><K><T><A><Q><T><V><L><V><V><V><V><V><F><G><I><S><W><L><P><H><H><I><I><H><L><W><A><E><F><G><V><F><P><L><T><P><A><S><F><L><F><R><I><T><A><H><C><L><A><Y><S><N><S><S><V><N><P><I><I><Y><A><F><L><S><E><N><F><R><K><A><Y><K><Q><V><F><K><C><H><I><R><K><D><S><H><L><S><D><T><K><E><S><K><S><R><I><D><T><P><P><S><T><N><C><T><H><V> | Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.<BOP> | P47211 |
P05014 | IFNA4_HUMAN | Interferon alpha-M1 | Homo | <M><A><L><S><F><S><L><L><M><A><V><L><V><L><S><Y><K><S><I><C><S><L><G><C><D><L><P><Q><T><H><S><L><G><N><R><R><A><L><I><L><L><A><Q><M><G><R><I><S><H><F><S><C><L><K><D><R><H><D><F><G><F><P><E><E><E><F><D><G><H><Q><F><Q><K><A><Q><A><I><S><V><L><H><E><M><I><Q><Q><T><F><N><L><F><S><T><E><D><S><S><A><A><W><E><Q><S><L><L><E><K><F><S><T><E><L><Y><Q><Q><L><N><D><L><E><A><C><V><I><Q><E><V><G><V><E><E><T><P><L><M><N><E><D><S><I><L><A><V><R><K><Y><F><Q><R><I><T><L><Y><L><T><E><K><K><Y><S><P><C><A><W><E><V><V><R><A><E><I><M><R><S><L><S><F><S><T><N><L><Q><K><R><L><R><R><K><D> | Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<BOP> | P05014 |
P51170 | SCNNG_HUMAN | SCNEG | Homo | <M><A><P><G><E><K><I><K><A><K><I><K><K><N><L><P><V><T><G><P><Q><A><P><T><I><K><E><L><M><R><W><Y><C><L><N><T><N><T><H><G><C><R><R><I><V><V><S><R><G><R><L><R><R><L><L><W><I><G><F><T><L><T><A><V><A><L><I><L><W><Q><C><A><L><L><V><F><S><F><Y><T><V><S><V><S><I><K><V><H><F><R><K><L><D><F><P><A><V><T><I><C><N><I><N><P><Y><K><Y><S><T><V><R><H><L><L><A><D><L><E><Q><E><T><R><E><A><L><K><S><L><Y><G><F><P><E><S><R><K><R><R><E><A><E><S><W><N><S><V><S><E><G><K><Q><P><R><F><S><H><R><I><P><L><L><I><F><D><Q><D><E><K><G><K><A><R><D><F><F><T><G><R><K><R><K><V><G><G><S><I><I><H><K><A><S><N><V><M><H><I><E><S><K><Q><V><V><G><F><Q><L><C><S><N><D><T><S><D><C><A><T><Y><T><F><S><S><G><I><N><A><I><Q><E><W><Y><K><L><H><Y><M><N><I><M><A><Q><V><P><L><E><K><K><I><N><M><S><Y><S><A><E><E><L><L><V><T><C><F><F><D><G><V><S><C><D><A><R><N><F><T><L><F><H><H><P><M><H><G><N><C><Y><T><F><N><N><R><E><N><E><T><I><L><S><T><S><M><G><G><S><E><Y><G><L><Q><V><I><L><Y><I><N><E><E><E><Y><N><P><F><L><V><S><S><T><G><A><K><V><I><I><H><R><Q><D><E><Y><P><F><V><E><D><V><G><T><E><I><E><T><A><M><V><T><S><I><G><M><H><L><T><E><S><F><K><L><S><E><P><Y><S><Q><C><T><E><D><G><S><D><V><P><I><R><N><I><Y><N><A><A><Y><S><L><Q><I><C><L><H><S><C><F><Q><T><K><M><V><E><K><C><G><C><A><Q><Y><S><Q><P><L><P><P><A><A><N><Y><C><N><Y><Q><Q><H><P><N><W><M><Y><C><Y><Y><Q><L><H><R><A><F><V><Q><E><E><L><G><C><Q><S><V><C><K><E><A><C><S><F><K><E><W><T><L><T><T><S><L><A><Q><W><P><S><V><V><S><E><K><W><L><L><P><V><L><T><W><D><Q><G><R><Q><V><N><K><K><L><N><K><T><D><L><A><K><L><L><I><F><Y><K><D><L><N><Q><R><S><I><M><E><S><P><A><N><S><I><E><M><L><L><S><N><F><G><G><Q><L><G><L><W><M><S><C><S><V><V><C><V><I><E><I><I><E><V><F><F><I><D><F><F><S><I><I><A><R><R><Q><W><Q><K><A><K><E><W><W><A><W><K><Q><A><P><P><C><P><E><A><P><R><S><P><Q><G><Q><D><N><P><A><L><D><I><D><D><D><L><P><T><F><N><S><A><L><H><L><P><P><A><L><G><T><Q><V><P><G><T><P><P><P><K><Y><N><T><L><R><L><E><R><A><F><S><N><Q><L><T><D><T><Q><M><L><D><E><L> | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.<BOP> | P51170 |
Q8WWV6 | FCAMR_HUMAN | Fc alpha/mu receptor | Homo | <M><P><L><F><L><I><L><C><L><L><Q><G><S><S><F><A><L><P><Q><K><R><P><H><P><R><W><L><W><E><G><S><L><P><S><R><T><H><L><R><A><M><G><T><L><R><P><S><S><P><L><C><W><R><E><E><S><S><F><A><A><P><N><S><L><K><G><S><R><L><V><S><G><E><P><G><G><A><V><T><I><Q><C><H><Y><A><P><S><S><V><N><R><H><Q><R><K><Y><W><C><R><L><G><P><P><R><W><I><C><Q><T><I><V><S><T><N><Q><Y><T><H><H><R><Y><R><D><R><V><A><L><T><D><F><P><Q><R><G><L><F><V><V><R><L><S><Q><L><S><P><D><D><I><G><C><Y><L><C><G><I><G><S><E><N><N><M><L><F><L><S><M><N><L><T><I><S><A><G><P><A><S><T><L><P><T><A><T><P><A><A><G><E><L><T><M><R><S><Y><G><T><A><S><P><V><A><N><R><W><T><P><G><T><T><Q><T><L><G><Q><G><T><A><W><D><T><V><A><S><T><P><G><T><S><K><T><T><A><S><A><E><G><R><R><T><P><G><A><T><R><P><A><A><P><G><T><G><S><W><A><E><G><S><V><K><A><P><A><P><I><P><E><S><P><P><S><K><S><R><S><M><S><N><T><T><E><G><V><W><E><G><T><R><S><S><V><T><N><R><A><R><A><S><K><D><R><R><E><M><T><T><T><K><A><D><R><P><R><E><D><I><E><G><V><R><I><A><L><D><A><A><K><K><V><L><G><T><I><G><P><P><A><L><V><S><E><T><L><A><W><E><I><L><P><Q><A><T><P><V><S><K><Q><Q><S><Q><G><S><I><G><E><T><T><P><A><A><G><M><W><T><L><G><T><P><A><A><D><V><W><I><L><G><T><P><A><A><D><V><W><T><S><M><E><A><A><S><G><E><G><S><A><A><G><D><L><D><A><A><T><G><D><R><G><P><Q><A><T><L><S><Q><T><P><A><V><G><P><W><G><P><P><G><K><E><S><S><V><K><R><T><F><P><E><D><E><S><S><S><R><T><L><A><P><V><S><T><M><L><A><L><F><M><L><M><A><L><V><L><L><Q><R><K><L><W><R><R><R><T><S><Q><E><A><E><R><V><T><L><I><Q><M><T><H><F><L><E><V><N><P><Q><A><D><Q><L><P><H><V><E><R><K><M><L><Q><D><D><S><L><P><A><G><A><S><L><T><A><P><E><R><N><P><G><P> | Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.<BOP> | Q8WWV6 |
P02763 | A1AG1_HUMAN | Orosomucoid-1 | Homo | <M><A><L><S><W><V><L><T><V><L><S><L><L><P><L><L><E><A><Q><I><P><L><C><A><N><L><V><P><V><P><I><T><N><A><T><L><D><R><I><T><G><K><W><F><Y><I><A><S><A><F><R><N><E><E><Y><N><K><S><V><Q><E><I><Q><A><T><F><F><Y><F><T><P><N><K><T><E><D><T><I><F><L><R><E><Y><Q><T><R><Q><D><Q><C><I><Y><N><T><T><Y><L><N><V><Q><R><E><N><G><T><I><S><R><Y><V><G><G><Q><E><H><F><A><H><L><L><I><L><R><D><T><K><T><Y><M><L><A><F><D><V><N><D><E><K><N><W><G><L><S><V><Y><A><D><K><P><E><T><T><K><E><Q><L><G><E><F><Y><E><A><L><D><C><L><R><I><P><K><S><D><V><V><Y><T><D><W><K><K><D><K><C><E><P><L><E><K><Q><H><E><K><E><R><K><Q><E><E><G><E><S> | Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.<BOP> | P02763 |
Q6PKH6 | DR4L2_HUMAN | Short chain dehydrogenase/reductase family 25C member 3 | Homo | <M><Q><M><A><R><L><L><G><L><C><A><W><A><R><K><S><V><R><M><A><S><S><R><M><T><R><R><D><P><L><T><N><K><V><A><L><V><T><A><S><T><D><G><I><G><F><A><I><A><R><R><L><A><Q><D><R><A><H><V><V><V><S><S><R><K><Q><Q><N><V><D><Q><A><V><A><T><L><Q><G><E><G><L><S><V><T><G><T><V><C><H><V><G><K><A><E><D><R><E><R><L><V><A><M><A><V><K><L><H><G><G><I><D><I><L><V><S><N><A><A><V><N><P><F><F><G><S><L><M><D><V><T><E><E><V><W><D><K><T><L><D><I><N><V><K><A><P><A><L><M><T><K><A><V><V><P><E><M><E><K><R><G><G><G><S><V><V><I><V><S><S><I><A><A><F><S><P><S><P><G><F><S><P><Y><N><V><S><K><T><A><L><L><G><L><N><N><T><L><A><I><E><L><A><P><R><N><I><R><V><N><C><L><H><L><D><L><S><R><L><A><S><A><G><C><S><G><W><T><R><K><K><R><K><A> | Probable oxidoreductase.<BOP> | Q6PKH6 |
P85299 | PRR5_HUMAN | Protein observed with Rictor-1 | Homo | <M><R><T><L><R><R><L><K><F><M><S><S><P><S><L><S><D><L><G><K><R><E><P><A><A><A><A><D><E><R><G><T><Q><Q><R><R><A><C><A><N><A><T><W><N><S><I><H><N><G><V><I><A><V><F><Q><R><K><G><L><P><D><Q><E><L><F><S><L><N><E><G><V><R><Q><L><L><K><T><E><L><G><S><F><F><T><E><Y><L><Q><N><Q><L><L><T><K><G><M><V><I><L><R><D><K><I><R><F><Y><E><G><Q><K><L><L><D><S><L><A><E><T><W><D><F><F><F><S><D><V><L><P><M><L><Q><A><I><F><Y><P><V><Q><G><K><E><P><S><V><R><Q><L><A><L><L><H><F><R><N><A><I><T><L><S><V><K><L><E><D><A><L><A><R><A><H><A><R><V><P><P><A><I><V><Q><M><L><L><V><L><Q><G><V><H><E><S><R><G><V><T><E><D><Y><L><R><L><E><T><L><V><Q><K><V><V><S><P><Y><L><G><T><Y><G><L><H><S><S><E><G><P><F><T><H><S><C><I><L><E><K><R><L><L><R><R><S><R><S><G><D><V><L><A><K><N><P><V><V><R><S><K><S><Y><N><T><P><L><L><N><P><V><Q><E><H><E><A><E><G><A><A><A><G><G><T><S><I><R><R><H><S><V><S><E><M><T><S><C><P><E><P><Q><G><F><S><D><P><P><G><Q><G><P><T><G><T><F><R><S><S><P><A><P><H><S><G><P><C><P><S><R><L><Y><P><T><T><Q><P><P><E><Q><G><L><D><P><T><R><S><S><L><P><R><S><S><P><E><N><L><V><D><Q><I><L><E><S><V><D><S><D><S><E><G><I><F><I><D><F><G><R><G><R><G><S><G><M><S><D><L><E><G><S><G><G><R><Q><S><V><V> | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.<BOP> | P85299 |
A6NNA2 | SRRM3_HUMAN | Serine/arginine repetitive matrix protein 3 | Homo | <M><S><S><T><V><N><N><G><A><A><S><M><Q><S><T><P><D><A><A><N><G><F><P><Q><P><S><S><S><S><G><T><W><P><R><A><E><E><E><L><R><A><A><E><P><G><L><V><K><R><A><H><R><E><I><L><D><H><E><R><K><R><R><V><E><L><K><C><M><E><L><Q><E><M><M><E><E><Q><G><Y><S><E><E><E><I><R><Q><K><V><G><T><F><R><Q><M><L><M><E><K><E><G><V><L><T><R><E><D><R><P><G><G><H><I><V><A><E><T><P><R><L><T><E><G><A><E><P><G><L><E><Y><A><P><F><D><D><D><D><G><P><V><D><C><D><C><P><A><S><C><Y><R><G><H><R><G><Y><R><T><K><H><W><S><S><S><S><A><S><P><P><P><K><K><K><K><K><K><K><G><G><H><R><R><S><R><K><K><R><R><L><E><S><E><C><S><C><G><S><S><S><P><L><R><K><K><K><K><S><V><K><K><H><R><R><D><R><S><D><S><G><S><R><R><K><R><R><H><R><S><R><S><S><K><C><K><R><K><E><K><N><K><E><K><K><R><P><H><T><E><S><P><G><R><R><S><H><R><H><S><S><G><S><S><H><S><P><S><L><S><S><H><Y><S><D><S><R><S><P><S><R><L><S><P><K><H><R><D><E><G><R><K><T><G><S><Q><R><S><S><G><S><R><S><P><S><P><S><G><G><S><G><W><G><S><P><Q><R><N><G><G><S><G><Q><R><S><G><A><H><G><G><R><P><G><S><A><H><S><P><P><D><K><P><S><S><P><S><P><R><V><R><D><K><A><A><A><A><A><P><T><P><P><A><R><G><K><E><S><P><S><P><R><S><A><P><S><S><Q><G><R><G><G><R><A><A><G><G><A><G><R><R><R><R><R><R><R><R><R><R><R><S><R><S><S><A><S><A><P><R><R><R><G><R><R><R><P><R><P><A><P><P><R><G><S><S><R><S><L><S><R><A><R><S><S><S><D><S><G><S><G><R><G><A><P><G><P><G><P><E><P><G><S><E><R><G><H><G><G><H><G><K><R><A><K><E><R><P><P><R><A><R><P><A><S><T><S><P><S><P><G><A><H><G><R><R><G><G><P><E><G><K><S><S><S><R><S><P><G><P><H><P><R><S><W><S><S><S><R><S><P><S><K><S><R><S><R><S><A><E><K><R><P><H><S><P><S><R><S><P><S><P><K><K><P><L><S><R><D><K><D><G><E><G><R><A><R><H><S><E><A><E><A><T><R><A><R><R><R><S><R><S><Y><S><P><I><R><K><R><R><R><D><S><P><S><F><M><E><P><R><R><I><T><S><A><A><S><V><L><F><H><T><T><G><P><A><P><L><P><P><P><A><A> | May play a role in regulating breast cancer cell invasiveness . May be involved in RYBP-mediated breast cancer progression .<BOP> | A6NNA2 |
Q8TAK5 | GABP2_HUMAN | GA-binding protein subunit beta-2 | Homo | <M><S><L><V><D><L><G><K><R><L><L><E><A><A><R><K><G><Q><D><D><E><V><R><T><L><M><A><N><G><A><P><F><T><T><D><W><L><G><T><S><P><L><H><L><A><A><Q><Y><G><H><Y><S><T><A><E><V><L><L><R><A><G><V><S><R><D><A><R><T><K><V><D><R><T><P><L><H><M><A><A><A><D><G><H><A><H><I><V><E><L><L><V><R><N><G><A><D><V><N><A><K><D><M><L><K><M><T><A><L><H><W><A><T><E><R><H><H><R><D><V><V><E><L><L><I><K><Y><G><A><D><V><H><A><F><S><K><F><D><K><S><A><F><D><I><A><L><E><K><N><N><A><E><I><L><V><I><L><Q><E><A><M><Q><N><Q><V><N><V><N><P><E><R><A><N><P><V><T><D><P><V><S><M><A><A><P><F><I><F><T><S><G><E><V><V><N><L><A><S><L><I><S><S><T><N><T><K><T><T><S><G><D><P><H><A><S><T><V><Q><F><S><N><S><T><T><S><V><L><A><T><L><A><A><L><A><E><A><S><V><P><L><S><N><S><H><R><A><T><A><N><T><E><E><I><I><E><G><N><S><V><D><S><S><I><Q><Q><V><M><G><S><G><G><Q><R><V><I><T><I><V><T><D><G><V><P><L><G><N><I><Q><T><S><I><P><T><G><G><I><G><Q><P><F><I><V><T><V><Q><D><G><Q><Q><V><L><T><V><P><A><G><K><V><A><E><E><T><V><I><K><E><E><E><E><E><K><L><P><L><T><K><K><P><R><I><G><E><K><T><N><S><V><E><E><S><K><E><G><N><E><R><E><L><L><Q><Q><Q><L><Q><E><A><N><R><R><A><Q><E><Y><R><H><Q><L><L><K><K><E><Q><E><A><E><Q><Y><R><L><K><L><E><A><I><A><R><Q><Q><P><N><G><V><D><F><T><M><V><E><E><V><A><E><V><D><A><V><V><V><T><E><G><E><L><E><E><R><E><T><K><V><T><G><S><A><G><T><T><E><P><H><T><R><V><S><M><A><T><V><S><S> | May function as transcription factor capable of interacting with purine rich repeats (GA repeats).<BOP> | Q8TAK5 |
Q13519 | PNOC_HUMAN | Orphanin FQ2 | Homo | <M><K><V><L><L><C><D><L><L><L><L><S><L><F><S><S><V><F><S><S><C><Q><R><D><C><L><T><C><Q><E><K><L><H><P><A><L><D><S><F><D><L><E><V><C><I><L><E><C><E><E><K><V><F><P><S><P><L><W><T><P><C><T><K><V><M><A><R><S><S><W><Q><L><S><P><A><A><P><E><H><V><A><A><A><L><Y><Q><P><R><A><S><E><M><Q><H><L><R><R><M><P><R><V><R><S><L><F><Q><E><Q><E><E><P><E><P><G><M><E><E><A><G><E><M><E><Q><K><Q><L><Q><K><R><F><G><G><F><T><G><A><R><K><S><A><R><K><L><A><N><Q><K><R><F><S><E><F><M><R><Q><Y><L><V><L><S><M><Q><S><S><Q><R><R><R><T><L><H><Q><N><G><N><V> | Has potent analgesic activity.<BOP> | Q13519 |
Q8WTQ1 | D104A_HUMAN | Defensin, beta 104 | Homo | <M><Q><R><L><V><L><L><L><A><I><S><L><L><L><Y><Q><D><L><P><V><R><S><E><F><E><L><D><R><I><C><G><Y><G><T><A><R><C><R><K><K><C><R><S><Q><E><Y><R><I><G><R><C><P><N><T><Y><A><C><C><L><R><K><W><D><E><S><L><L><N><R><T><K><P> | Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.<BOP> | Q8WTQ1 |
O43734 | CIKS_HUMAN | TRAF3-interacting protein 2 | Homo | <M><P><P><Q><L><Q><E><T><R><M><N><R><S><I><P><V><E><V><D><E><S><E><P><Y><P><S><Q><L><L><K><P><I><P><E><Y><S><P><E><E><E><S><E><P><P><A><P><N><I><R><N><M><A><P><N><S><L><S><A><P><T><M><L><H><N><S><S><G><D><F><S><Q><A><H><S><T><L><K><L><A><N><H><Q><R><P><V><S><R><Q><V><T><C><L><R><T><Q><V><L><E><D><S><E><D><S><F><C><R><R><H><P><G><L><G><K><A><F><P><S><G><C><S><A><V><S><E><P><A><S><E><S><V><V><G><A><L><P><A><E><H><Q><F><S><F><M><E><K><R><N><Q><W><L><V><S><Q><L><S><A><A><S><P><D><T><G><H><D><S><D><K><S><D><Q><S><L><P><N><A><S><A><D><S><L><G><G><S><Q><E><M><V><Q><R><P><Q><P><H><R><N><R><A><G><L><D><L><P><T><I><D><T><G><Y><D><S><Q><P><Q><D><V><L><G><I><R><Q><L><E><R><P><L><P><L><T><S><V><C><Y><P><Q><D><L><P><R><P><L><R><S><R><E><F><P><Q><F><E><P><Q><R><Y><P><A><C><A><Q><M><L><P><P><N><L><S><P><H><A><P><W><N><Y><H><Y><H><C><P><G><S><P><D><H><Q><V><P><Y><G><H><D><Y><P><R><A><A><Y><Q><Q><V><I><Q><P><A><L><P><G><Q><P><L><P><G><A><S><V><R><G><L><H><P><V><Q><K><V><I><L><N><Y><P><S><P><W><D><H><E><E><R><P><A><Q><R><D><C><S><F><P><G><L><P><R><H><Q><D><Q><P><H><H><Q><P><P><N><R><A><G><A><P><G><E><S><L><E><C><P><A><E><L><R><P><Q><V><P><Q><P><P><S><P><A><A><V><P><R><P><P><S><N><P><P><A><R><G><T><L><K><T><S><N><L><P><E><E><L><R><K><V><F><I><T><Y><S><M><D><T><A><M><E><V><V><K><F><V><N><F><L><L><V><N><G><F><Q><T><A><I><D><I><F><E><D><R><I><R><G><I><D><I><I><K><W><M><E><R><Y><L><R><D><K><T><V><M><I><I><V><A><I><S><P><K><Y><K><Q><D><V><E><G><A><E><S><Q><L><D><E><D><E><H><G><L><H><T><K><Y><I><H><R><M><M><Q><I><E><F><I><K><Q><G><S><M><N><F><R><F><I><P><V><L><F><P><N><A><K><K><E><H><V><P><T><W><L><Q><N><T><H><V><Y><S><W><P><K><N><K><K><N><I><L><L><R><L><L><R><E><E><E><Y><V><A><P><P><R><G><P><L><P><T><L><Q><V><V><P><L> | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling . Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein . Essential adapter molecule in IL17A-mediated signaling . Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways .<BOP> | O43734 |
P11279 | LAMP1_HUMAN | CD107 antigen-like family member A | Homo | <M><A><A><P><G><S><A><R><R><P><L><L><L><L><L><L><L><L><L><L><G><L><M><H><C><A><S><A><A><M><F><M><V><K><N><G><N><G><T><A><C><I><M><A><N><F><S><A><A><F><S><V><N><Y><D><T><K><S><G><P><K><N><M><T><F><D><L><P><S><D><A><T><V><V><L><N><R><S><S><C><G><K><E><N><T><S><D><P><S><L><V><I><A><F><G><R><G><H><T><L><T><L><N><F><T><R><N><A><T><R><Y><S><V><Q><L><M><S><F><V><Y><N><L><S><D><T><H><L><F><P><N><A><S><S><K><E><I><K><T><V><E><S><I><T><D><I><R><A><D><I><D><K><K><Y><R><C><V><S><G><T><Q><V><H><M><N><N><V><T><V><T><L><H><D><A><T><I><Q><A><Y><L><S><N><S><S><F><S><R><G><E><T><R><C><E><Q><D><R><P><S><P><T><T><A><P><P><A><P><P><S><P><S><P><S><P><V><P><K><S><P><S><V><D><K><Y><N><V><S><G><T><N><G><T><C><L><L><A><S><M><G><L><Q><L><N><L><T><Y><E><R><K><D><N><T><T><V><T><R><L><L><N><I><N><P><N><K><T><S><A><S><G><S><C><G><A><H><L><V><T><L><E><L><H><S><E><G><T><T><V><L><L><F><Q><F><G><M><N><A><S><S><S><R><F><F><L><Q><G><I><Q><L><N><T><I><L><P><D><A><R><D><P><A><F><K><A><A><N><G><S><L><R><A><L><Q><A><T><V><G><N><S><Y><K><C><N><A><E><E><H><V><R><V><T><K><A><F><S><V><N><I><F><K><V><W><V><Q><A><F><K><V><E><G><G><Q><F><G><S><V><E><E><C><L><L><D><E><N><S><M><L><I><P><I><A><V><G><G><A><L><A><G><L><V><L><I><V><L><I><A><Y><L><V><G><R><K><R><S><H><A><G><Y><Q><T><I> | (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.<BOP> | P11279 |
Q9BQS2 | SYT15_HUMAN | Synaptotagmin XV | Homo | <M><A><E><Q><L><A><L><V><I><G><G><T><I><G><G><L><L><L><L><L><L><I><G><A><S><C><C><L><W><R><R><F><C><A><T><L><T><Y><E><E><L><P><G><T><P><A><M><A><T><T><A><A><S><S><G><Q><R><D><R><P><C><Q><P><H><A><R><T><Q><L><S><R><P><P><A><V><P><F><V><V><P><P><T><L><Q><G><R><D><W><V><P><L><H><S><G><E><W><A><D><A><P><W><D><P><C><P><A><S><E><L><L><P><H><T><S><S><G><G><L><G><D><A><C><M><V><G><A><I><N><P><E><L><Y><K><F><P><E><D><K><S><E><T><D><F><P><D><G><C><L><G><R><L><W><F><S><V><E><Y><E><Q><E><A><E><R><L><L><V><G><L><I><K><A><Q><H><L><Q><A><P><S><E><T><C><S><P><L><V><K><L><Y><L><L><P><D><E><R><R><F><L><Q><S><K><T><K><R><K><T><S><N><P><Q><F><D><E><H><F><I><F><Q><V><S><S><K><T><I><T><Q><R><V><L><K><F><S><V><Y><H><V><D><R><Q><R><K><H><Q><L><L><G><Q><V><L><F><P><L><K><N><E><T><L><V><G><D><C><R><R><V><I><W><R><D><L><E><A><E><S><L><E><P><P><S><E><F><G><D><L><Q><F><C><L><S><Y><N><D><Y><L><S><R><L><T><V><V><V><L><R><A><K><G><L><R><L><Q><E><D><R><G><I><V><S><V><F><V><K><V><S><L><M><N><H><N><K><F><V><K><C><K><K><T><S><A><V><L><G><S><I><N><P><V><Y><N><E><T><F><S><F><K><A><D><A><T><E><L><D><T><A><S><L><S><L><T><V><V><Q><N><M><E><G><D><K><S><Q><Q><L><G><R><V><V><V><G><P><Y><M><Y><T><R><G><R><E><L><E><H><W><D><E><M><L><S><K><P><K><E><L><V><K><R><W><H><A><L><C><R><T><T><E><P> | May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.<BOP> | Q9BQS2 |
P36542 | ATPG_HUMAN | F-ATPase gamma subunit | Homo | <M><F><S><R><A><G><V><A><G><L><S><A><W><T><L><Q><P><Q><W><I><Q><V><R><N><M><A><T><L><K><D><I><T><R><R><L><K><S><I><K><N><I><Q><K><I><T><K><S><M><K><M><V><A><A><A><K><Y><A><R><A><E><R><E><L><K><P><A><R><I><Y><G><L><G><S><L><A><L><Y><E><K><A><D><I><K><G><P><E><D><K><K><K><H><L><L><I><G><V><S><S><D><R><G><L><C><G><A><I><H><S><S><I><A><K><Q><M><K><S><E><V><A><T><L><T><A><A><G><K><E><V><M><L><V><G><I><G><D><K><I><R><G><I><L><Y><R><T><H><S><D><Q><F><L><V><A><F><K><E><V><G><R><K><P><P><T><F><G><D><A><S><V><I><A><L><E><L><L><N><S><G><Y><E><F><D><E><G><S><I><I><F><N><K><F><R><S><V><I><S><Y><K><T><E><E><K><P><I><F><S><L><N><T><V><A><S><A><D><S><M><S><I><Y><D><D><I><D><A><D><V><L><Q><N><Y><Q><E><Y><N><L><A><N><I><I><Y><Y><S><L><K><E><S><T><T><S><E><Q><S><A><R><M><T><A><M><D><N><A><S><K><N><A><S><E><M><I><D><K><L><T><L><T><F><N><R><T><R><Q><A><V><I><T><K><E><L><I><E><I><I><S><G><A><A><A><L><D> | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.<BOP> | P36542 |
A0A075B6V5 | TVA36_HUMAN | T cell receptor alpha variable 36/delta variable 7 | Homo | <M><M><K><C><P><Q><A><L><L><A><I><F><W><L><L><L><S><W><V><S><S><E><D><K><V><V><Q><S><P><L><S><L><V><V><H><E><G><D><T><V><T><L><N><C><S><Y><E><V><T><N><F><R><S><L><L><W><Y><K><Q><E><K><K><A><P><T><F><L><F><M><L><T><S><S><G><I><E><K><K><S><G><R><L><S><S><I><L><D><K><K><E><L><F><S><I><L><N><I><T><A><T><Q><T><G><D><S><A><I><Y><L><C><A><V><E> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A075B6V5 |
Q53F39 | MPPE1_HUMAN | Post-GPI attachment to proteins factor 5 | Homo | <M><A><M><I><E><L><G><F><G><R><Q><N><F><H><P><L><K><R><K><S><S><L><L><L><K><L><I><A><V><V><F><A><V><L><L><F><C><E><F><L><I><Y><Y><L><A><I><F><Q><C><N><W><P><E><V><K><T><T><A><S><D><G><E><Q><T><T><R><E><P><V><L><K><A><M><F><L><A><D><T><H><L><L><G><E><F><L><G><H><W><L><D><K><L><R><R><E><W><Q><M><E><R><A><F><Q><T><A><L><W><L><L><Q><P><E><V><V><F><I><L><G><D><I><F><D><E><G><K><W><S><T><P><E><A><W><A><D><D><V><E><R><F><Q><K><M><F><R><H><P><S><H><V><Q><L><K><V><V><A><G><N><H><D><I><G><F><H><Y><E><M><N><T><Y><K><V><E><R><F><E><K><V><F><S><S><E><R><L><F><S><W><K><G><I><N><F><V><M><V><N><S><V><A><L><N><G><D><G><C><G><I><C><S><E><T><E><A><E><L><I><E><V><S><H><R><L><N><C><S><R><E><A><R><G><S><S><R><C><G><P><G><P><L><L><P><T><S><A><P><V><L><L><Q><H><Y><P><L><Y><R><R><S><D><A><N><C><S><G><E><D><A><A><P><A><E><E><R><D><I><P><F><K><E><N><Y><D><V><L><S><R><E><A><S><Q><K><L><L><W><W><L><Q><P><R><L><V><L><S><G><H><T><H><S><A><C><E><V><H><H><G><G><R><V><P><E><L><S><V><P><S><F><S><W><R><N><R><N><N><P><S><F><I><M><G><S><I><T><P><T><D><Y><T><L><S><K><C><Y><L><P><R><E><D><V><V><L><I><I><Y><C><G><V><V><G><F><L><V><V><L><T><L><T><H><F><G><L><L><A><S><P><F><L><S><G><L><N><L><L><G><K><R><K><T><R> | Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.<BOP> | Q53F39 |
Q92804 | RBP56_HUMAN | RNA-binding protein 56 | Homo | <M><S><D><S><G><S><Y><G><Q><S><G><G><E><Q><Q><S><Y><S><T><Y><G><N><P><G><S><Q><G><Y><G><Q><A><S><Q><S><Y><S><G><Y><G><Q><T><T><D><S><S><Y><G><Q><N><Y><S><G><Y><S><S><Y><G><Q><S><Q><S><G><Y><S><Q><S><Y><G><G><Y><E><N><Q><K><Q><S><S><Y><S><Q><Q><P><Y><N><N><Q><G><Q><Q><Q><N><M><E><S><S><G><S><Q><G><G><R><A><P><S><Y><D><Q><P><D><Y><G><Q><Q><D><S><Y><D><Q><Q><S><G><Y><D><Q><H><Q><G><S><Y><D><E><Q><S><N><Y><D><Q><Q><H><D><S><Y><S><Q><N><Q><Q><S><Y><H><S><Q><R><E><N><Y><S><H><H><T><Q><D><D><R><R><D><V><S><R><Y><G><E><D><N><R><G><Y><G><G><S><Q><G><G><G><R><G><R><G><G><Y><D><K><D><G><R><G><P><M><T><G><S><S><G><G><D><R><G><G><F><K><N><F><G><G><H><R><D><Y><G><P><R><T><D><A><D><S><E><S><D><N><S><D><N><N><T><I><F><V><Q><G><L><G><E><G><V><S><T><D><Q><V><G><E><F><F><K><Q><I><G><I><I><K><T><N><K><K><T><G><K><P><M><I><N><L><Y><T><D><K><D><T><G><K><P><K><G><E><A><T><V><S><F><D><D><P><P><S><A><K><A><A><I><D><W><F><D><G><K><E><F><H><G><N><I><I><K><V><S><F><A><T><R><R><P><E><F><M><R><G><G><G><S><G><G><G><R><R><G><R><G><G><Y><R><G><R><G><G><F><Q><G><R><G><G><D><P><K><S><G><D><W><V><C><P><N><P><S><C><G><N><M><N><F><A><R><R><N><S><C><N><Q><C><N><E><P><R><P><E><D><S><R><P><S><G><G><D><F><R><G><R><G><Y><G><G><E><R><G><Y><R><G><R><G><G><R><G><G><D><R><G><G><Y><G><G><D><R><S><G><G><G><Y><G><G><D><R><S><S><G><G><G><Y><S><G><D><R><S><G><G><G><Y><G><G><D><R><S><G><G><G><Y><G><G><D><R><G><G><G><Y><G><G><D><R><G><G><G><Y><G><G><D><R><G><G><G><Y><G><G><D><R><G><G><Y><G><G><D><R><G><G><G><Y><G><G><D><R><G><G><Y><G><G><D><R><G><G><Y><G><G><D><R><G><G><Y><G><G><D><R><G><G><Y><G><G><D><R><S><R><G><G><Y><G><G><D><R><G><G><G><S><G><Y><G><G><D><R><S><G><G><Y><G><G><D><R><S><G><G><G><Y><G><G><D><R><G><G><G><Y><G><G><D><R><G><G><Y><G><G><K><M><G><G><R><N><D><Y><R><N><D><Q><R><N><R><P><Y> | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).<BOP> | Q92804 |
Q9NPD7 | NRN1_HUMAN | Neuritin | Homo | <M><G><L><K><L><N><G><R><Y><I><S><L><I><L><A><V><Q><I><A><Y><L><V><Q><A><V><R><A><A><G><K><C><D><A><V><F><K><G><F><S><D><C><L><L><K><L><G><D><S><M><A><N><Y><P><Q><G><L><D><D><K><T><N><I><K><T><V><C><T><Y><W><E><D><F><H><S><C><T><V><T><A><L><T><D><C><Q><E><G><A><K><D><M><W><D><K><L><R><K><E><S><K><N><L><N><I><Q><G><S><L><F><E><L><C><G><S><G><N><G><A><A><G><S><L><L><P><A><F><P><V><L><L><V><S><L><S><A><A><L><A><T><W><L><S><F> | Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.<BOP> | Q9NPD7 |
Q8NFH8 | REPS2_HUMAN | RalBP1-interacting protein 2 | Homo | <M><E><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><G><G><G><C><G><S><G><P><P><P><L><L><L><S><E><G><E><Q><Q><C><Y><S><E><L><F><A><R><C><A><G><A><A><G><G><G><P><G><S><G><P><P><E><A><A><R><V><A><P><G><T><A><T><A><A><A><G><P><V><A><D><L><F><R><A><S><Q><L><P><A><E><T><L><H><Q><I><T><E><L><C><G><A><K><R><V><G><Y><F><G><P><T><Q><F><Y><I><A><L><K><L><I><A><A><A><Q><S><G><L><P><V><R><I><E><S><I><K><C><E><L><P><L><P><R><F><M><M><S><K><N><D><G><E><I><R><F><G><N><P><A><E><L><H><G><T><K><V><Q><I><P><Y><L><T><T><E><K><N><S><F><K><R><M><D><D><E><D><K><Q><Q><E><T><Q><S><P><T><M><S><P><L><A><S><P><P><S><S><P><P><H><Y><Q><R><V><P><L><S><H><G><Y><S><K><L><R><S><S><A><E><Q><M><H><P><A><P><Y><E><A><R><Q><P><L><V><Q><P><E><G><S><S><S><G><G><P><G><T><K><P><L><R><H><Q><A><S><L><I><R><S><F><S><V><E><R><E><L><Q><D><N><S><S><Y><P><D><E><P><W><R><I><T><E><E><Q><R><E><Y><Y><V><N><Q><F><R><S><L><Q><P><D><P><S><S><F><I><S><G><S><V><A><K><N><F><F><T><K><S><K><L><S><I><P><E><L><S><Y><I><W><E><L><S><D><A><D><C><D><G><A><L><T><L><P><E><F><C><A><A><F><H><L><I><V><A><R><K><N><G><Y><P><L><P><E><G><L><P><P><T><L><Q><P><E><Y><L><Q><A><A><F><P><K><P><K><W><D><C><Q><L><F><D><S><Y><S><E><S><L><P><A><N><Q><Q><P><R><D><L><N><R><M><E><K><T><S><V><K><D><M><A><D><L><P><V><P><N><Q><D><V><T><S><D><D><K><Q><A><L><K><S><T><I><N><E><A><L><P><K><D><V><S><E><D><P><A><T><P><K><D><S><N><S><L><K><A><R><P><R><S><R><S><Y><S><S><T><S><I><E><E><A><M><K><R><G><E><D><P><P><T><P><P><P><R><P><Q><K><T><H><S><R><A><S><S><L><D><L><N><K><V><F><Q><P><S><V><P><A><T><K><S><G><L><L><P><P><P><P><A><L><P><P><R><P><C><P><S><Q><S><E><Q><V><S><E><A><E><L><L><P><Q><L><S><R><A><P><S><Q><A><A><E><S><S><P><A><K><K><D><V><L><Y><S><Q><P><P><S><K><P><I><R><R><K><F><R><P><E><N><Q><A><T><E><N><Q><E><P><S><T><A><A><S><G><P><A><S><A><A><T><M><K><P><H><P><T><V><Q><K><Q><S><S><K><Q><K><K><A><I><Q><T><A><I><R><K><N><K><E><A><N><A><V><L><A><R><L><N><S><E><L><Q><Q><Q><L><K><E><V><H><Q><E><R><I><A><L><E><N><Q><L><E><Q><L><R><P><V><T><V><L> | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway . By controlling growth factor receptors endocytosis may regulate cell survival . Through ASAP1 may regulate cell adhesion and migration .<BOP> | Q8NFH8 |
Q5TA76 | LCE3A_HUMAN | Late envelope protein 13 | Homo | <M><S><C><Q><Q><N><Q><Q><Q><C><Q><P><P><P><K><C><P><A><K><S><P><A><Q><C><L><P><P><A><S><S><S><C><A><P><S><S><G><G><C><G><P><S><S><E><R><S><C><C><L><S><H><H><R><C><R><R><S><H><R><C><R><C><Q><S><S><N><S><C><D><R><G><S><G><Q><Q><G><G><S><S><S><C><G><H><S><S><A><G><C><C> | A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens .<BOP> | Q5TA76 |
Q96IZ0 | PAWR_HUMAN | Prostate apoptosis response 4 protein | Homo | <M><A><T><G><G><Y><R><T><S><S><G><L><G><G><S><T><T><D><F><L><E><E><W><K><A><K><R><E><K><M><R><A><K><Q><N><P><P><G><P><A><P><P><G><G><G><S><S><D><A><A><G><K><P><P><A><G><A><L><G><T><P><A><A><A><A><A><N><E><L><N><N><N><L><P><G><G><A><P><A><A><P><A><V><P><G><P><G><G><V><N><C><A><V><G><S><A><M><L><T><R><A><A><P><G><P><R><R><S><E><D><E><P><P><A><A><S><A><S><A><A><P><P><P><Q><R><D><E><E><E><P><D><G><V><P><E><K><G><K><S><S><G><P><S><A><R><K><G><K><G><Q><I><E><K><R><K><L><R><E><K><R><R><S><T><G><V><V><N><I><P><A><A><E><C><L><D><E><Y><E><D><D><E><A><G><Q><K><E><R><K><R><E><D><A><I><T><Q><Q><N><T><I><Q><N><E><A><V><N><L><L><D><P><G><S><S><Y><L><L><Q><E><P><P><R><T><V><S><G><R><Y><K><S><T><T><S><V><S><E><E><D><V><S><S><R><Y><S><R><T><D><R><S><G><F><P><R><Y><N><R><D><A><N><V><S><G><T><L><V><S><S><S><T><L><E><K><K><I><E><D><L><E><K><E><V><V><R><E><R><Q><E><N><L><R><L><V><R><L><M><Q><D><K><E><E><M><I><G><K><L><K><E><E><I><D><L><L><N><R><D><L><D><D><I><E><D><E><N><E><Q><L><K><Q><E><N><K><T><L><L><K><V><V><G><Q><L><T><R> | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.<BOP> | Q96IZ0 |
O43488 | ARK72_HUMAN | Succinic semialdehyde reductase | Homo | <M><L><S><A><A><S><R><V><V><S><R><A><A><V><H><C><A><L><R><S><P><P><P><E><A><R><A><L><A><M><S><R><P><P><P><P><R><V><A><S><V><L><G><T><M><E><M><G><R><R><M><D><A><P><A><S><A><A><A><V><R><A><F><L><E><R><G><H><T><E><L><D><T><A><F><M><Y><S><D><G><Q><S><E><T><I><L><G><G><L><G><L><G><L><G><G><G><D><C><R><V><K><I><A><T><K><A><N><P><W><D><G><K><S><L><K><P><D><S><V><R><S><Q><L><E><T><S><L><K><R><L><Q><C><P><Q><V><D><L><F><Y><L><H><A><P><D><H><G><T><P><V><E><E><T><L><H><A><C><Q><R><L><H><Q><E><G><K><F><V><E><L><G><L><S><N><Y><A><S><W><E><V><A><E><I><C><T><L><C><K><S><N><G><W><I><L><P><T><V><Y><Q><G><M><Y><N><A><T><T><R><Q><V><E><T><E><L><F><P><C><L><R><H><F><G><L><R><F><Y><A><Y><N><P><L><A><G><G><L><L><T><G><K><Y><K><Y><E><D><K><D><G><K><Q><P><V><G><R><F><F><G><N><S><W><A><E><T><Y><R><N><R><F><W><K><E><H><H><F><E><A><I><A><L><V><E><K><A><L><Q><A><A><Y><G><A><S><A><P><S><V><T><S><A><A><L><R><W><M><Y><H><H><S><Q><L><Q><G><A><H><G><D><A><V><I><L><G><M><S><S><L><E><Q><L><E><Q><N><L><A><A><T><E><E><G><P><L><E><P><A><V><V><D><A><F><N><Q><A><W><H><L><V><A><H><E><C><P><N><Y><F><R> | Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.<BOP> | O43488 |
P60673 | PROF3_HUMAN | Profilin III | Homo | <M><G><D><W><K><V><Y><I><S><A><V><L><R><D><Q><R><I><D><D><V><A><I><V><G><H><A><D><N><S><C><V><W><A><S><R><P><G><G><L><L><A><A><I><S><P><Q><E><V><G><V><L><T><G><P><D><R><H><T><F><L><Q><A><G><L><S><V><G><G><R><R><C><C><V><I><R><D><H><L><L><A><E><G><D><G><V><L><D><A><R><T><K><G><L><D><A><R><A><V><C><V><G><R><A><P><R><A><L><L><V><L><M><G><R><R><G><V><H><G><G><I><L><N><K><T><V><H><E><L><I><R><G><L><R><M><Q><G><A> | Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis.<BOP> | P60673 |
P10323 | ACRO_HUMAN | Acrosin heavy chain | Homo | <M><V><E><M><L><P><T><A><I><L><L><V><L><A><V><S><V><V><A><K><D><N><A><T><C><D><G><P><C><G><L><R><F><R><Q><N><P><Q><G><G><V><R><I><V><G><G><K><A><A><Q><H><G><A><W><P><W><M><V><S><L><Q><I><F><T><Y><N><S><H><R><Y><H><T><C><G><G><S><L><L><N><S><R><W><V><L><T><A><A><H><C><F><V><G><K><N><N><V><H><D><W><R><L><V><F><G><A><K><E><I><T><Y><G><N><N><K><P><V><K><A><P><L><Q><E><R><Y><V><E><K><I><I><I><H><E><K><Y><N><S><A><T><E><G><N><D><I><A><L><V><E><I><T><P><P><I><S><C><G><R><F><I><G><P><G><C><L><P><H><F><K><A><G><L><P><R><G><S><Q><S><C><W><V><A><G><W><G><Y><I><E><E><K><A><P><R><P><S><S><I><L><M><E><A><R><V><D><L><I><D><L><D><L><C><N><S><T><Q><W><Y><N><G><R><V><Q><P><T><N><V><C><A><G><Y><P><V><G><K><I><D><T><C><Q><G><D><S><G><G><P><L><M><C><K><D><S><K><E><S><A><Y><V><V><V><G><I><T><S><W><G><V><G><C><A><R><A><K><R><P><G><I><Y><T><A><T><W><P><Y><L><N><W><I><A><S><K><I><G><S><N><A><L><R><M><I><Q><S><A><T><P><P><P><P><T><T><R><P><P><P><I><R><P><P><F><S><H><P><I><S><A><H><L><P><W><Y><F><Q><P><P><P><R><P><L><P><P><R><P><P><A><A><Q><P><R><P><P><P><S><P><P><P><P><P><P><P><P><A><S><P><L><P><P><P><P><P><P><P><P><P><T><P><S><S><T><T><K><L><P><Q><G><L><S><F><A><K><R><L><Q><Q><L><I><E><V><L><K><G><K><T><Y><S><D><G><K><N><H><Y><D><M><E><T><T><E><L><P><E><L><T><S><T><S> | Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.<BOP> | P10323 |
O60934 | NBN_HUMAN | Nijmegen breakage syndrome protein 1 | Homo | <M><W><K><L><L><P><A><A><G><P><A><G><G><E><P><Y><R><L><L><T><G><V><E><Y><V><V><G><R><K><N><C><A><I><L><I><E><N><D><Q><S><I><S><R><N><H><A><V><L><T><A><N><F><S><V><T><N><L><S><Q><T><D><E><I><P><V><L><T><L><K><D><N><S><K><Y><G><T><F><V><N><E><E><K><M><Q><N><G><F><S><R><T><L><K><S><G><D><G><I><T><F><G><V><F><G><S><K><F><R><I><E><Y><E><P><L><V><A><C><S><S><C><L><D><V><S><G><K><T><A><L><N><Q><A><I><L><Q><L><G><G><F><T><V><N><N><W><T><E><E><C><T><H><L><V><M><V><S><V><K><V><T><I><K><T><I><C><A><L><I><C><G><R><P><I><V><K><P><E><Y><F><T><E><F><L><K><A><V><E><S><K><K><Q><P><P><Q><I><E><S><F><Y><P><P><L><D><E><P><S><I><G><S><K><N><V><D><L><S><G><R><Q><E><R><K><Q><I><F><K><G><K><T><F><I><F><L><N><A><K><Q><H><K><K><L><S><S><A><V><V><F><G><G><G><E><A><R><L><I><T><E><E><N><E><E><E><H><N><F><F><L><A><P><G><T><C><V><V><D><T><G><I><T><N><S><Q><T><L><I><P><D><C><Q><K><K><W><I><Q><S><I><M><D><M><L><Q><R><Q><G><L><R><P><I><P><E><A><E><I><G><L><A><V><I><F><M><T><T><K><N><Y><C><D><P><Q><G><H><P><S><T><G><L><K><T><T><T><P><G><P><S><L><S><Q><G><V><S><V><D><E><K><L><M><P><S><A><P><V><N><T><T><T><Y><V><A><D><T><E><S><E><Q><A><D><T><W><D><L><S><E><R><P><K><E><I><K><V><S><K><M><E><Q><K><F><R><M><L><S><Q><D><A><P><T><V><K><E><S><C><K><T><S><S><N><N><N><S><M><V><S><N><T><L><A><K><M><R><I><P><N><Y><Q><L><S><P><T><K><L><P><S><I><N><K><S><K><D><R><A><S><Q><Q><Q><Q><T><N><S><I><R><N><Y><F><Q><P><S><T><K><K><R><E><R><D><E><E><N><Q><E><M><S><S><C><K><S><A><R><I><E><T><S><C><S><L><L><E><Q><T><Q><P><A><T><P><S><L><W><K><N><K><E><Q><H><L><S><E><N><E><P><V><D><T><N><S><D><N><N><L><F><T><D><T><D><L><K><S><I><V><K><N><S><A><S><K><S><H><A><A><E><K><L><R><S><N><K><K><R><E><M><D><D><V><A><I><E><D><E><V><L><E><Q><L><F><K><D><T><K><P><E><L><E><I><D><V><K><V><Q><K><Q><E><E><D><V><N><V><R><K><R><P><R><M><D><I><E><T><N><D><T><F><S><D><E><A><V><P><E><S><S><K><I><S><Q><E><N><E><I><G><K><K><R><E><L><K><E><D><S><L><W><S><A><K><E><I><S><N><N><D><K><L><Q><D><D><S><E><M><L><P><K><K><L><L><L><T><E><F><R><S><L><V><I><K><N><S><T><S><R><N><P><S><G><I><N><D><D><Y><G><Q><L><K><N><F><K><K><F><K><K><V><T><Y><P><G><A><G><K><L><P><H><I><I><G><G><S><D><L><I><A><H><H><A><R><K><N><T><E><L><E><E><W><L><R><Q><E><M><E><V><Q><N><Q><H><A><K><E><E><S><L><A><D><D><L><F><R><Y><N><P><Y><L><K><R><R><R> | Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 | O60934 |
Q8TDL5 | BPIB1_HUMAN | von Ebner minor salivary gland protein | Homo | <M><A><G><P><W><T><F><T><L><L><C><G><L><L><A><A><T><L><I><Q><A><T><L><S><P><T><A><V><L><I><L><G><P><K><V><I><K><E><K><L><T><Q><E><L><K><D><H><N><A><T><S><I><L><Q><Q><L><P><L><L><S><A><M><R><E><K><P><A><G><G><I><P><V><L><G><S><L><V><N><T><V><L><K><H><I><I><W><L><K><V><I><T><A><N><I><L><Q><L><Q><V><K><P><S><A><N><D><Q><E><L><L><V><K><I><P><L><D><M><V><A><G><F><N><T><P><L><V><K><T><I><V><E><F><H><M><T><T><E><A><Q><A><T><I><R><M><D><T><S><A><S><G><P><T><R><L><V><L><S><D><C><A><T><S><H><G><S><L><R><I><Q><L><L><H><K><L><S><F><L><V><N><A><L><A><K><Q><V><M><N><L><L><V><P><S><L><P><N><L><V><K><N><Q><L><C><P><V><I><E><A><S><F><N><G><M><Y><A><D><L><L><Q><L><V><K><V><P><I><S><L><S><I><D><R><L><E><F><D><L><L><Y><P><A><I><K><G><D><T><I><Q><L><Y><L><G><A><K><L><L><D><S><Q><G><K><V><T><K><W><F><N><N><S><A><A><S><L><T><M><P><T><L><D><N><I><P><F><S><L><I><V><S><Q><D><V><V><K><A><A><V><A><A><V><L><S><P><E><E><F><M><V><L><L><D><S><V><L><P><E><S><A><H><R><L><K><S><S><I><G><L><I><N><E><K><A><A><D><K><L><G><S><T><Q><I><V><K><I><L><T><Q><D><T><P><E><F><F><I><D><Q><G><H><A><K><V><A><Q><L><I><V><L><E><V><F><P><S><S><E><A><L><R><P><L><F><T><L><G><I><E><A><S><S><E><A><Q><F><Y><T><K><G><D><Q><L><I><L><N><L><N><N><I><S><S><D><R><I><Q><L><M><N><S><G><I><G><W><F><Q><P><D><V><L><K><N><I><I><T><E><I><I><H><S><I><L><L><P><N><Q><N><G><K><L><R><S><G><V><P><V><S><L><V><K><A><L><G><F><E><A><A><E><S><S><L><T><K><D><A><L><V><L><T><P><A><S><L><W><K><P><S><S><P><V><S><Q> | May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.<BOP> | Q8TDL5 |
Q9GZQ4 | NMUR2_HUMAN | G-protein coupled receptor TGR-1 | Homo | <M><S><G><M><E><K><L><Q><N><A><S><W><I><Y><Q><Q><K><L><E><D><P><F><Q><K><H><L><N><S><T><E><E><Y><L><A><F><L><C><G><P><R><R><S><H><F><F><L><P><V><S><V><V><Y><V><P><I><F><V><V><G><V><I><G><N><V><L><V><C><L><V><I><L><Q><H><Q><A><M><K><T><P><T><N><Y><Y><L><F><S><L><A><V><S><D><L><L><V><L><L><L><G><M><P><L><E><V><Y><E><M><W><R><N><Y><P><F><L><F><G><P><V><G><C><Y><F><K><T><A><L><F><E><T><V><C><F><A><S><I><L><S><I><T><T><V><S><V><E><R><Y><V><A><I><L><H><P><F><R><A><K><L><Q><S><T><R><R><R><A><L><R><I><L><G><I><V><W><G><F><S><V><L><F><S><L><P><N><T><S><I><H><G><I><K><F><H><Y><F><P><N><G><S><L><V><P><G><S><A><T><C><T><V><I><K><P><M><W><I><Y><N><F><I><I><Q><V><T><S><F><L><F><Y><L><L><P><M><T><V><I><S><V><L><Y><Y><L><M><A><L><R><L><K><K><D><K><S><L><E><A><D><E><G><N><A><N><I><Q><R><P><C><R><K><S><V><N><K><M><L><F><V><L><V><L><V><F><A><I><C><W><A><P><F><H><I><D><R><L><F><F><S><F><V><E><E><W><S><E><S><L><A><A><V><F><N><L><V><H><V><V><S><G><V><F><F><Y><L><S><S><A><V><N><P><I><I><Y><N><L><L><S><R><R><F><Q><A><A><F><Q><N><V><I><S><S><F><H><K><Q><W><H><S><Q><H><D><P><Q><L><P><P><A><Q><R><N><I><F><L><T><E><C><H><F><V><E><L><T><E><D><I><G><P><Q><F><P><C><Q><S><S><M><H><N><S><H><L><P><A><A><L><S><S><E><Q><M><S><R><T><N><Y><Q><S><F><H><F><N><K><T> | Receptor for the neuromedin-U and neuromedin-S neuropeptides.<BOP> | Q9GZQ4 |
O00461 | GOLI4_HUMAN | Golgi-localized phosphoprotein of 130 kDa | Homo | <M><G><N><G><M><C><S><R><K><Q><K><R><I><F><Q><T><L><L><L><L><T><V><V><F><G><F><L><Y><G><A><M><L><Y><Y><E><L><Q><T><Q><L><R><K><A><E><A><V><A><L><K><Y><Q><Q><H><Q><E><S><L><S><A><Q><L><Q><V><V><Y><E><H><R><S><R><L><E><K><S><L><Q><K><E><R><L><E><H><K><K><A><K><E><D><F><L><V><Y><K><L><E><A><Q><E><T><L><N><K><G><R><Q><D><S><N><S><R><Y><S><A><L><N><V><Q><H><Q><M><L><K><S><Q><H><E><E><L><K><K><Q><H><S><D><L><E><E><E><H><R><K><Q><G><E><D><F><S><R><T><F><N><D><H><K><Q><K><Y><L><Q><L><Q><Q><E><K><E><Q><E><L><S><K><L><K><E><T><V><Y><N><L><R><E><E><N><R><Q><L><R><K><A><H><Q><D><I><H><T><Q><L><Q><D><V><K><Q><Q><H><K><N><L><L><S><E><H><E><Q><L><V><V><T><L><E><D><H><K><S><A><L><A><A><A><Q><T><Q><V><A><E><Y><K><Q><L><K><D><T><L><N><R><I><P><S><L><R><K><P><D><P><A><E><Q><Q><N><V><T><Q><V><A><H><S><P><Q><G><Y><N><T><A><R><E><K><P><T><R><E><V><Q><E><V><S><R><N><N><D><V><W><Q><N><H><E><A><V><P><G><R><A><E><D><T><K><L><Y><A><P><T><H><K><E><A><E><F><Q><A><P><P><E><P><I><Q><Q><E><V><E><R><R><E><P><E><E><H><Q><V><E><E><E><H><R><K><A><L><E><E><E><E><M><E><Q><V><G><Q><A><E><H><L><E><E><E><H><D><P><S><P><E><E><Q><D><R><E><W><K><E><Q><H><E><Q><R><E><A><A><N><L><L><E><G><H><A><R><A><E><V><Y><P><S><A><K><P><M><I><K><F><Q><S><P><Y><E><E><Q><L><E><Q><Q><R><L><A><V><Q><Q><V><E><E><A><Q><Q><L><R><E><H><Q><E><A><L><H><Q><Q><R><L><Q><G><H><L><L><R><Q><Q><E><Q><Q><Q><Q><Q><V><A><R><E><M><A><L><Q><R><Q><A><E><L><E><E><G><R><P><Q><H><Q><E><Q><L><R><Q><Q><A><H><Y><D><A><M><D><N><D><I><V><Q><G><A><E><D><Q><G><I><Q><G><E><E><G><A><Y><E><R><D><N><Q><H><Q><D><E><A><E><G><D><P><G><N><R><H><E><P><R><E><Q><G><P><R><E><A><D><P><E><S><E><A><D><R><A><A><V><E><D><I><N><P><A><D><D><P><N><N><Q><G><E><D><E><F><E><E><A><E><Q><V><R><E><E><N><L><P><D><E><N><E><E><Q><K><Q><S><N><Q><K><Q><E><N><T><E><V><E><E><H><L><V><M><A><G><N><P><D><Q><Q><E><D><N><V><D><E><Q><Y><Q><E><E><A><E><E><E><V><Q><E><D><L><T><E><E><K><K><R><E><L><E><H><N><A><E><E><T><Y><G><E><N><D><E><N><T><D><D><K><N><N><D><G><E><E><Q><E><V><R><D><D><N><R><P><K><G><R><E><E><H><Y><E><E><E><E><E><E><E><E><D><G><A><A><V><A><E><K><S><H><R><R><A><E><M> | Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.<BOP> | O00461 |
P34130 | NTF4_HUMAN | Neutrophic factor 4 | Homo | <M><L><P><L><P><S><C><S><L><P><I><L><L><L><F><L><L><P><S><V><P><I><E><S><Q><P><P><P><S><T><L><P><P><F><L><A><P><E><W><D><L><L><S><P><R><V><V><L><S><R><G><A><P><A><G><P><P><L><L><F><L><L><E><A><G><A><F><R><E><S><A><G><A><P><A><N><R><S><R><R><G><V><S><E><T><A><P><A><S><R><R><G><E><L><A><V><C><D><A><V><S><G><W><V><T><D><R><R><T><A><V><D><L><R><G><R><E><V><E><V><L><G><E><V><P><A><A><G><G><S><P><L><R><Q><Y><F><F><E><T><R><C><K><A><D><N><A><E><E><G><G><P><G><A><G><G><G><G><C><R><G><V><D><R><R><H><W><V><S><E><C><K><A><K><Q><S><Y><V><R><A><L><T><A><D><A><Q><G><R><V><G><W><R><W><I><R><I><D><T><A><C><V><C><T><L><L><S><R><T><G><R><A> | Target-derived survival factor for peripheral sensory sympathetic neurons.<BOP> | P34130 |
Q8WWG9 | KCNE4_HUMAN | Potassium channel subunit beta MiRP3 | Homo | <M><H><F><L><T><I><Y><P><N><C><S><S><G><V><V><R><A><Q><S><R><T><E><Q><K><N><P><L><G><L><D><D><L><G><I><Q><N><L><G><Q><T><V><S><L><A><P><A><V><E><A><A><S><M><L><K><M><E><P><L><N><S><T><H><P><G><T><A><A><S><S><S><P><L><E><S><R><A><A><G><G><G><S><G><N><G><N><E><Y><F><Y><I><L><V><V><M><S><F><Y><G><I><F><L><I><G><I><M><L><G><Y><M><K><S><K><R><R><E><K><K><S><S><L><L><L><L><Y><K><D><E><E><R><L><W><G><E><A><M><K><P><L><P><V><V><S><G><L><R><S><V><Q><V><P><L><M><L><N><M><L><Q><E><S><V><A><P><A><L><S><C><T><L><C><S><M><E><G><D><S><V><S><S><E><S><S><S><P><D><V><H><L><T><I><Q><E><E><G><A><D><D><E><L><E><E><T><S><E><T><P><L><N><E><S><S><E><G><S><S><E><N><I><H><Q><N><S> | Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.<BOP> | Q8WWG9 |
Q13214 | SEM3B_HUMAN | Semaphorin-V | Homo | <M><G><R><A><G><A><A><A><V><I><P><G><L><A><L><L><W><A><V><G><L><G><S><A><A><P><S><P><P><R><L><R><L><S><F><Q><E><L><Q><A><W><H><G><L><Q><T><F><S><L><E><R><T><C><C><Y><Q><A><L><L><V><D><E><E><R><G><R><L><F><V><G><A><E><N><H><V><A><S><L><N><L><D><N><I><S><K><R><A><K><K><L><A><W><P><A><P><V><E><W><R><E><E><C><N><W><A><G><K><D><I><G><T><E><C><M><N><F><V><K><L><L><H><A><Y><N><R><T><H><L><L><A><C><G><T><G><A><F><H><P><T><C><A><F><V><E><V><G><H><R><A><E><E><P><V><L><R><L><D><P><G><R><I><E><D><G><K><G><K><S><P><Y><D><P><R><H><R><A><A><S><V><L><V><G><E><E><L><Y><S><G><V><A><A><D><L><M><G><R><D><F><T><I><F><R><S><L><G><Q><R><P><S><L><R><T><E><P><H><D><S><R><W><L><N><E><P><K><F><V><K><V><F><W><I><P><E><S><E><N><P><D><D><D><K><I><Y><F><F><F><R><E><T><A><V><E><A><A><P><A><L><G><R><L><S><V><S><R><V><G><Q><I><C><R><N><D><V><G><G><Q><R><S><L><V><N><K><W><T><T><F><L><K><A><R><L><V><C><S><V><P><G><V><E><G><D><T><H><F><D><Q><L><Q><D><V><F><L><L><S><S><R><D><H><R><T><P><L><L><Y><A><V><F><S><T><S><S><S><I><F><Q><G><S><A><V><C><V><Y><S><M><N><D><V><R><R><A><F><L><G><P><F><A><H><K><E><G><P><M><H><Q><W><V><S><Y><Q><G><R><V><P><Y><P><R><P><G><M><C><P><S><K><T><F><G><T><F><S><S><T><K><D><F><P><D><D><V><I><Q><F><A><R><N><H><P><L><M><Y><N><S><V><L><P><T><G><G><R><P><L><F><L><Q><V><G><A><N><Y><T><F><T><Q><I><A><A><D><R><V><A><A><A><D><G><H><Y><D><V><L><F><I><G><T><D><V><G><T><V><L><K><V><I><S><V><P><K><G><S><R><P><S><A><E><G><L><L><L><E><E><L><H><V><F><E><D><S><A><A><V><T><S><M><Q><I><S><S><K><R><H><Q><L><Y><V><A><S><R><S><A><V><A><Q><I><A><L><H><R><C><A><A><H><G><R><V><C><T><E><C><C><L><A><R><D><P><Y><C><A><W><D><G><V><A><C><T><R><F><Q><P><S><A><K><R><R><F><R><R><Q><D><V><R><N><G><D><P><S><T><L><C><S><G><D><S><S><R><P><A><L><L><E><H><K><V><F><G><V><E><G><S><S><A><F><L><E><C><E><P><R><S><L><Q><A><R><V><E><W><T><F><Q><R><A><G><V><T><A><H><T><Q><V><L><A><E><E><R><T><E><R><T><A><R><G><L><L><L><R><R><L><R><R><R><D><S><G><V><Y><L><C><A><A><V><E><Q><G><F><T><Q><P><L><R><R><L><S><L><H><V><L><S><A><T><Q><A><E><R><L><A><R><A><E><E><A><A><P><A><A><P><P><G><P><K><L><W><Y><R><D><F><L><Q><L><V><E><P><G><G><G><G><S><A><N><S><L><R><M><C><R><P><Q><P><A><L><Q><S><L><P><L><E><S><R><R><K><G><R><N><R><R><T><H><A><P><E><P><R><A><E><R><G><P><R><S><A><T><H><W> | Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.<BOP> | Q13214 |
P32297 | ACHA3_HUMAN | Neuronal acetylcholine receptor subunit alpha-3 | Homo | <M><G><S><G><P><L><S><L><P><L><A><L><S><P><P><R><L><L><L><L><L><L><L><S><L><L><P><V><A><R><A><S><E><A><E><H><R><L><F><E><R><L><F><E><D><Y><N><E><I><I><R><P><V><A><N><V><S><D><P><V><I><I><H><F><E><V><S><M><S><Q><L><V><K><V><D><E><V><N><Q><I><M><E><T><N><L><W><L><K><Q><I><W><N><D><Y><K><L><K><W><N><P><S><D><Y><G><G><A><E><F><M><R><V><P><A><Q><K><I><W><K><P><D><I><V><L><Y><N><N><A><V><G><D><F><Q><V><D><D><K><T><K><A><L><L><K><Y><T><G><E><V><T><W><I><P><P><A><I><F><K><S><S><C><K><I><D><V><T><Y><F><P><F><D><Y><Q><N><C><T><M><K><F><G><S><W><S><Y><D><K><A><K><I><D><L><V><L><I><G><S><S><M><N><L><K><D><Y><W><E><S><G><E><W><A><I><I><K><A><P><G><Y><K><H><D><I><K><Y><N><C><C><E><E><I><Y><P><D><I><T><Y><S><L><Y><I><R><R><L><P><L><F><Y><T><I><N><L><I><I><P><C><L><L><I><S><F><L><T><V><L><V><F><Y><L><P><S><D><C><G><E><K><V><T><L><C><I><S><V><L><L><S><L><T><V><F><L><L><V><I><T><E><T><I><P><S><T><S><L><V><I><P><L><I><G><E><Y><L><L><F><T><M><I><F><V><T><L><S><I><V><I><T><V><F><V><L><N><V><H><Y><R><T><P><T><T><H><T><M><P><S><W><V><K><T><V><F><L><N><L><L><P><R><V><M><F><M><T><R><P><T><S><N><E><G><N><A><Q><K><P><R><P><L><Y><G><A><E><L><S><N><L><N><C><F><S><R><A><E><S><K><G><C><K><E><G><Y><P><C><Q><D><G><M><C><G><Y><C><H><H><R><R><I><K><I><S><N><F><S><A><N><L><T><R><S><S><S><S><E><S><V><D><A><V><L><S><L><S><A><L><S><P><E><I><K><E><A><I><Q><S><V><K><Y><I><A><E><N><M><K><A><Q><N><E><A><K><E><I><Q><D><D><W><K><Y><V><A><M><V><I><D><R><I><F><L><W><V><F><T><L><V><C><I><L><G><T><A><G><L><F><L><Q><P><L><M><A><R><E><D><A> | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.<BOP> | P32297 |
Q9Y3B3 | TMED7_HUMAN | p27 | Homo | <M><P><R><P><G><S><A><Q><R><W><A><A><V><A><G><R><W><G><C><R><L><L><A><L><L><L><L><V><P><G><P><G><G><A><S><E><I><T><F><E><L><P><D><N><A><K><Q><C><F><Y><E><D><I><A><Q><G><T><K><C><T><L><E><F><Q><V><I><T><G><G><H><Y><D><V><D><C><R><L><E><D><P><D><G><K><V><L><Y><K><E><M><K><K><Q><Y><D><S><F><T><F><T><A><S><K><N><G><T><Y><K><F><C><F><S><N><E><F><S><T><F><T><H><K><T><V><Y><F><D><F><Q><V><G><E><D><P><P><L><F><P><S><E><N><R><V><S><A><L><T><Q><M><E><S><A><C><V><S><I><H><E><A><L><K><S><V><I><D><Y><Q><T><H><F><R><L><R><E><A><Q><G><R><S><R><A><E><D><L><N><T><R><V><A><Y><W><S><V><G><E><A><L><I><L><L><V><V><S><I><G><Q><V><F><L><L><K><S><F><F><S><D><K><R><T><T><T><T><R><V><G><S> | Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.<BOP> | Q9Y3B3 |
Q8TCG2 | P4K2B_HUMAN | Phosphatidylinositol 4-kinase type II-beta | Homo | <M><E><D><P><S><E><P><D><R><L><A><S><A><D><G><G><S><P><E><E><E><E><D><G><E><R><E><P><L><L><P><R><I><A><W><A><H><P><R><R><G><A><P><G><S><A><V><R><L><L><D><A><A><G><E><E><G><E><A><G><D><E><E><L><P><L><P><P><G><D><V><G><V><S><R><S><S><S><A><E><L><D><R><S><R><P><A><V><S><V><T><I><G><T><S><E><M><N><A><F><L><D><D><P><E><F><A><D><I><M><L><R><A><E><Q><A><I><E><V><G><I><F><P><E><R><I><S><Q><G><S><S><G><S><Y><F><V><K><D><P><K><R><K><I><I><G><V><F><K><P><K><S><E><E><P><Y><G><Q><L><N><P><K><W><T><K><Y><V><H><K><V><C><C><P><C><C><F><G><R><G><C><L><I><P><N><Q><G><Y><L><S><E><A><G><A><Y><L><V><D><N><K><L><H><L><S><I><V><P><K><T><K><V><V><W><L><V><S><E><T><F><N><Y><N><A><I><D><R><A><K><S><R><G><K><K><Y><A><L><E><K><V><P><K><V><G><R><K><F><H><R><I><G><L><P><P><K><I><G><S><F><Q><L><F><V><E><G><Y><K><E><A><E><Y><W><L><R><K><F><E><A><D><P><L><P><E><N><I><R><K><Q><F><Q><S><Q><F><E><R><L><V><I><L><D><Y><I><I><R><N><T><D><R><G><N><D><N><W><L><V><R><Y><E><K><Q><K><C><E><K><E><I><D><H><K><E><S><K><W><I><D><D><E><E><F><L><I><K><I><A><A><I><D><N><G><L><A><F><P><F><K><H><P><D><E><W><R><A><Y><P><F><H><W><A><W><L><P><Q><A><K><V><P><F><S><E><E><I><R><N><L><I><L><P><Y><I><S><D><M><N><F><V><Q><D><L><C><E><D><L><Y><E><L><F><K><T><D><K><G><F><D><K><A><T><F><E><S><Q><M><S><V><M><R><G><Q><I><L><N><L><T><Q><A><L><R><D><G><K><S><P><F><Q><L><V><Q><I><P><C><V><I><V><E><R><S><Q><G><G><S><Q><G><R><I><V><H><L><S><N><S><F><T><Q><T><V><N><C><R><K><P><F><F><S><S><W> | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell . This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments . The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) . Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.<BOP> | Q8TCG2 |
O96007 | MOC2B_HUMAN | Molybdopterin-synthase large subunit | Homo | <M><S><S><L><E><I><S><S><S><C><F><S><L><E><T><K><L><P><L><S><P><P><L><V><E><D><S><A><F><E><P><S><R><K><D><M><D><E><V><E><E><K><S><K><D><V><I><N><F><T><A><E><K><L><S><V><D><E><V><S><Q><L><V><I><S><P><L><C><G><A><I><S><L><F><V><G><T><T><R><N><N><F><E><G><K><K><V><I><S><L><E><Y><E><A><Y><L><P><M><A><E><N><E><V><R><K><I><C><S><D><I><R><Q><K><W><P><V><K><H><I><A><V><F><H><R><L><G><L><V><P><V><S><E><A><S><I><I><I><A><V><S><S><A><H><R><A><A><S><L><E><A><V><S><Y><A><I><D><T><L><K><A><K><V><P><I><W><K><K><E><I><Y><E><E><S><S><T><W><K><G><N><K><E><C><F><W><A><S><N><S> | Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.<BOP> | O96007 |
Q7Z5A8 | TAFA3_HUMAN | Chemokine-like protein TAFA-3 | Homo | <M><S><E><R><V><E><R><N><W><S><T><G><G><W><L><L><A><L><C><L><A><W><L><W><T><H><L><T><L><A><A><L><Q><P><P><T><A><T><V><L><V><Q><Q><G><T><C><E><V><I><A><A><H><R><C><C><N><R><N><R><I><E><E><R><S><Q><T><V><K><C><S><C><F><S><G><Q><V><A><G><T><T><R><A><K><P><S><C><V><D><A><S><I><V><L><Q><R><W><W><C><Q><M><E><P><C><L><P><G><E><E><C><K><V><L><P><D><L><S><G><W><S><C><S><S><G><H><K><V><K><T><T><K><V><T><R> | Plays a role in the regulation of microglia polarization.<BOP> | Q7Z5A8 |
P01258 | CALC_HUMAN | PDN-21 | Homo | <M><G><F><Q><K><F><S><P><F><L><A><L><S><I><L><V><L><L><Q><A><G><S><L><H><A><A><P><F><R><S><A><L><E><S><S><P><A><D><P><A><T><L><S><E><D><E><A><R><L><L><L><A><A><L><V><Q><D><Y><V><Q><M><K><A><S><E><L><E><Q><E><Q><E><R><E><G><S><S><L><D><S><P><R><S><K><R><C><G><N><L><S><T><C><M><L><G><T><Y><T><Q><D><F><N><K><F><H><T><F><P><Q><T><A><I><G><V><G><A><P><G><K><K><R><D><M><S><S><D><L><E><R><D><H><R><P><H><V><S><M><P><Q><N><A><N> | Katacalcin is a potent plasma calcium-lowering peptide.<BOP> | P01258 |
P0DMS9 | TMIG3_HUMAN | Transmembrane domain-containing protein TMIGD3 | Homo | <M><E><G><S><P><A><G><P><I><E><Q><K><E><A><R><W><E><S><S><W><E><E><Q><P><D><W><T><L><G><C><L><S><P><E><S><Q><F><R><I><P><G><L><P><G><C><I><L><S><F><Q><L><K><V><C><F><L><P><V><M><W><L><F><I><L><L><S><L><A><L><I><S><D><A><M><V><M><D><E><K><V><K><R><S><F><V><L><D><T><A><S><A><I><C><N><Y><N><A><H><Y><K><N><H><P><K><Y><W><C><R><G><Y><F><R><D><Y><C><N><I><I><A><F><S><P><N><S><T><N><H><V><A><L><R><D><T><G><N><Q><L><I><V><T><M><S><C><L><T><K><E><D><T><G><W><Y><W><C><G><I><Q><R><D><F><A><R><D><D><M><D><F><T><E><L><I><V><T><D><D><K><G><T><L><A><N><D><F><W><S><G><K><D><L><S><G><N><K><T><R><S><C><K><A><P><K><V><V><R><K><A><D><R><S><R><T><S><I><L><I><I><C><I><L><I><T><G><L><G><I><I><S><V><I><S><H><L><T><K><R><R><R><S><Q><R><N><R><R><V><G><N><T><L><K><P><F><S><R><V><L><T><P><K><E><M><A><P><T><E><Q><M> | Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity .<BOP> | P0DMS9 |
P18825 | ADA2C_HUMAN | Alpha-2C adrenoreceptor | Homo | <M><A><S><P><A><L><A><A><A><L><A><V><A><A><A><A><G><P><N><A><S><G><A><G><E><R><G><S><G><G><V><A><N><A><S><G><A><S><W><G><P><P><R><G><Q><Y><S><A><G><A><V><A><G><L><A><A><V><V><G><F><L><I><V><F><T><V><V><G><N><V><L><V><V><I><A><V><L><T><S><R><A><L><R><A><P><Q><N><L><F><L><V><S><L><A><S><A><D><I><L><V><A><T><L><V><M><P><F><S><L><A><N><E><L><M><A><Y><W><Y><F><G><Q><V><W><C><G><V><Y><L><A><L><D><V><L><F><C><T><S><S><I><V><H><L><C><A><I><S><L><D><R><Y><W><S><V><T><Q><A><V><E><Y><N><L><K><R><T><P><R><R><V><K><A><T><I><V><A><V><W><L><I><S><A><V><I><S><F><P><P><L><V><S><L><Y><R><Q><P><D><G><A><A><Y><P><Q><C><G><L><N><D><E><T><W><Y><I><L><S><S><C><I><G><S><F><F><A><P><C><L><I><M><G><L><V><Y><A><R><I><Y><R><V><A><K><L><R><T><R><T><L><S><E><K><R><A><P><V><G><P><D><G><A><S><P><T><T><E><N><G><L><G><A><A><A><G><A><G><E><N><G><H><C><A><P><P><P><A><D><V><E><P><D><E><S><S><A><A><A><E><R><R><R><R><R><G><A><L><R><R><G><G><R><R><R><A><G><A><E><G><G><A><G><G><A><D><G><Q><G><A><G><P><G><A><A><E><S><G><A><L><T><A><S><R><S><P><G><P><G><G><R><L><S><R><A><S><S><R><S><V><E><F><F><L><S><R><R><R><R><A><R><S><S><V><C><R><R><K><V><A><Q><A><R><E><K><R><F><T><F><V><L><A><V><V><M><G><V><F><V><L><C><W><F><P><F><F><F><S><Y><S><L><Y><G><I><C><R><E><A><C><Q><V><P><G><P><L><F><K><F><F><F><W><I><G><Y><C><N><S><S><L><N><P><V><I><Y><T><V><F><N><Q><D><F><R><R><S><F><K><H><I><L><F><R><R><R><R><R><G><F><R><Q> | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.<BOP> | P18825 |
Q86WW8 | COA5_HUMAN | Cytochrome c oxidase assembly factor 5 | Homo | <M><P><K><Y><Y><E><D><K><P><Q><G><G><A><C><A><G><L><K><E><D><L><G><A><C><L><L><Q><S><D><C><V><V><Q><E><G><K><S><P><R><Q><C><L><K><E><G><Y><C><N><S><L><K><Y><A><F><F><E><C><K><R><S><V><L><D><N><R><A><R><F><R><G><R><K><G><Y> | Involved in an early step of the mitochondrial complex IV assembly process.<BOP> | Q86WW8 |
Q0ZLH3 | PJVK_HUMAN | Autosomal recessive deafness type 59 protein | Homo | <M><F><A><A><A><T><K><S><F><V><K><Q><V><G><D><G><G><R><L><V><P><V><P><S><L><S><E><A><D><K><Y><Q><P><L><S><L><V><V><K><K><K><R><C><F><L><F><P><R><Y><K><F><T><S><T><P><F><T><L><K><D><I><L><L><G><D><R><E><I><S><A><G><I><S><S><Y><Q><L><L><N><Y><E><D><E><S><D><V><S><L><Y><G><R><R><G><N><H><I><V><N><D><V><G><I><N><V><A><G><S><D><S><I><A><V><K><A><S><F><G><I><V><T><K><H><E><V><E><V><S><T><L><L><K><E><I><T><T><R><K><I><N><F><D><H><S><L><I><R><Q><S><R><S><S><R><K><A><V><L><C><V><V><M><E><S><I><R><T><T><R><Q><C><S><L><S><V><H><A><G><I><R><G><E><A><M><R><F><H><F><M><D><E><Q><N><P><K><G><R><D><K><A><I><V><F><P><A><H><T><T><I><A><F><S><V><F><E><L><F><I><Y><L><D><G><A><F><D><L><C><V><T><S><V><S><K><G><G><F><E><R><E><E><T><A><T><F><A><L><L><Y><R><L><R><N><I><L><F><E><R><N><R><R><V><M><D><V><I><S><R><S><Q><L><Y><L><D><D><L><F><S><D><Y><Y><D><K><P><L><S><M><T><D><I><S><L><K><E><G><T><H><I><R><V><N><L><L><N><H><N><I><P><K><G><P><C><I><L><C><G><M><G><N><F><K><R><E><T><V><Y><G><C><F><Q><C><S><V><D><G><Q><K><Y><V><R><L><H><A><V><P><C><F><D><I><W><H><K><R><M><K> | Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation.<BOP> | Q0ZLH3 |
Q8IYN0 | ZN100_HUMAN | Zinc finger protein 100 | Homo | <M><D><D><P><R><Y><G><M><C><P><L><K><G><A><S><G><C><P><G><A><E><R><S><L><L><V><Q><S><Y><F><E><K><G><P><L><T><F><R><D><V><A><I><E><F><S><L><E><E><W><Q><C><L><D><S><A><Q><Q><G><L><Y><R><K><V><M><L><E><N><Y><R><N><L><V><F><L><A><G><I><A><L><T><K><P><D><L><I><T><C><L><E><Q><G><K><E><P><W><N><I><K><R><H><E><M><V><A><K><P><P><V><I><C><S><H><F><P><Q><D><L><W><A><E><Q><D><I><K><D><S><F><Q><E><A><I><L><K><K><Y><G><K><Y><G><H><D><N><L><Q><L><Q><K><G><C><K><S><V><D><E><C><K><V><H><K><E><H><D><N><K><L><N><Q><C><L><I><T><T><Q><S><N><I><F><Q><C><D><P><S><A><K><V><F><H><T><F><S><N><S><N><R><H><K><I><R><H><T><R><K><K><P><F><K><C><K><K><C><E><K><S><F><C><M><L><L><H><L><T><Q><H><K><R><F><H><I><T><E><N><S><Y><Q><C><K><D><C><G><K><A><F><N><W><F><S><T><L><T><T><H><R><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><H><L><T><T><H><K><I><I><H><T><G><E><K><P><Y><R><C><E><E><C><G><K><A><F><N><R><S><S><H><L><T><T><H><K><R><I><H><T><G><V><K><P><Y><K><C><T><E><C><G><K><A><F><N><R><S><S><H><L><T><T><H><R><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><T><L><T><T><H><K><I><T><H><A><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><Y><R><F><S><Y><L><T><K><H><K><T><S><H><T><G><E><K><F><Y><K><C><E><E><C><G><K><G><F><N><W><S><S><A><L><T><K><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><E><S><S><N><L><T><T><H><K><M><I><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><A><F><N><R><S><S><Q><L><T><A><H><K><M><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><T><L><T><K><H><K><I><T><H><T><G><E><K><S><Y><K><W><E><E><C><G><K><D><F><N><Q><S><L><S><L><I><K><Q><N><N><S><Y><W><R><E><T><L><Q><M> | May be involved in transcriptional regulation.<BOP> | Q8IYN0 |
Q8NC06 | ACBD4_HUMAN | Acyl-CoA-binding domain-containing protein 4 | Homo | <M><G><T><E><K><E><S><P><E><P><D><C><Q><K><Q><F><Q><A><A><V><S><V><I><Q><N><L><P><K><N><G><S><Y><R><P><S><Y><E><E><M><L><R><F><Y><S><Y><Y><K><Q><A><T><M><G><P><C><L><V><P><R><P><G><F><W><D><P><I><G><R><Y><K><W><D><A><W><N><S><L><G><K><M><S><R><E><E><A><M><S><A><Y><I><T><E><M><K><L><V><A><Q><K><V><I><D><T><V><P><L><G><E><V><A><E><D><M><F><G><Y><F><E><P><L><Y><Q><V><I><P><D><M><P><R><P><P><E><T><F><L><R><R><V><T><G><W><K><E><Q><V><V><N><G><D><V><G><A><V><S><E><P><P><C><L><P><K><E><P><A><P><P><S><P><E><S><H><S><P><R><D><L><D><S><E><V><F><C><D><S><L><E><Q><L><E><P><E><L><S><S><G><Q><H><L><E><E><S><V><I><P><G><T><A><P><C><P><P><Q><R><K><R><G><C><G><A><A><R><R><G><P><R><S><W><T><C><G><C><W><G><Q><F><E><H><Y><R><R><A><C><R><R><C><R><R><G><C><R><A><W><R><A><C><P><G><P><L><S><S><L><T><L><S><V><R><L><E> | Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.<BOP> | Q8NC06 |
Q96MX6 | DAA10_HUMAN | WD repeat-containing protein Monad | Homo | <M><S><A><F><E><K><P><Q><I><I><A><H><I><Q><K><G><F><N><Y><T><V><F><D><C><K><W><V><P><C><S><A><K><F><V><T><M><G><N><F><A><R><G><T><G><V><I><Q><L><Y><E><I><Q><H><G><D><L><K><L><L><R><E><I><E><K><A><K><P><I><K><C><G><T><F><G><A><T><S><L><Q><Q><R><Y><L><A><T><G><D><F><G><G><N><L><H><I><W><N><L><E><A><P><E><M><P><V><Y><S><V><K><G><H><K><E><I><I><N><A><I><D><G><I><G><G><L><G><I><G><E><G><A><P><E><I><V><T><G><S><R><D><G><T><V><K><V><W><D><P><R><Q><K><D><D><P><V><A><N><M><E><P><V><Q><G><E><N><K><R><D><C><W><T><V><A><F><G><N><A><Y><N><Q><E><E><R><V><V><C><A><G><Y><D><N><G><D><I><K><L><F><D><L><R><N><M><A><L><R><W><E><T><N><I><K><N><G><V><C><S><L><E><F><D><R><K><D><I><S><M><N><K><L><V><A><T><S><L><E><G><K><F><H><V><F><D><M><R><T><Q><H><P><T><K><G><F><A><S><V><S><E><K><A><H><K><S><T><V><W><Q><V><R><H><L><P><Q><N><R><E><L><F><L><T><A><G><G><A><G><G><L><H><L><W><K><Y><E><Y><P><I><Q><R><S><K><K><D><S><E><G><I><E><M><G><V><A><G><S><V><S><L><L><Q><N><V><T><L><S><T><Q><P><I><S><S><L><D><W><S><P><D><K><R><G><L><C><V><C><S><S><F><D><Q><T><V><R><V><L><I><V><T><K><L><N><K><I> | Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.<BOP> | Q96MX6 |
Q13145 | BAMBI_HUMAN | Putative transmembrane protein NMA | Homo | <M><D><R><H><S><S><Y><I><F><I><W><L><Q><L><E><L><C><A><M><A><V><L><L><T><K><G><E><I><R><C><Y><C><D><A><A><H><C><V><A><T><G><Y><M><C><K><S><E><L><S><A><C><F><S><R><L><L><D><P><Q><N><S><N><S><P><L><T><H><G><C><L><D><S><L><A><S><T><T><D><I><C><Q><A><K><Q><A><R><N><H><S><G><T><T><I><P><T><L><E><C><C><H><E><D><M><C><N><Y><R><G><L><H><D><V><L><S><P><P><R><G><E><A><S><G><Q><G><N><R><Y><Q><H><D><G><S><R><N><L><I><T><K><V><Q><E><L><T><S><S><K><E><L><W><F><R><A><A><V><I><A><V><P><I><A><G><G><L><I><L><V><L><L><I><M><L><A><L><R><M><L><R><S><E><N><K><R><L><Q><D><Q><R><Q><Q><M><L><S><R><L><H><Y><S><F><H><G><H><H><S><K><K><G><Q><V><A><K><L><D><L><E><C><M><V><P><V><S><G><H><E><N><C><C><L><T><C><D><K><M><R><Q><A><D><L><S><N><D><K><I><L><S><L><V><H><W><G><M><Y><S><G><H><G><K><L><E><F><V> | Negatively regulates TGF-beta signaling.<BOP> | Q13145 |
Q6P3W2 | DJC24_HUMAN | Diphthamide biosynthesis protein 4 | Homo | <M><M><A><V><E><Q><M><P><K><K><D><W><Y><S><I><L><G><A><D><P><S><A><N><I><S><D><L><K><Q><K><Y><Q><K><L><I><L><M><Y><H><P><D><K><Q><S><T><D><V><P><A><G><T><V><E><E><C><V><Q><K><F><I><E><I><D><Q><A><W><K><I><L><G><N><E><E><T><K><R><E><Y><D><L><Q><R><C><E><D><D><L><R><N><V><G><P><V><D><A><Q><V><Y><L><E><E><M><S><W><N><E><G><D><H><S><F><Y><L><S><C><R><C><G><G><K><Y><S><V><S><K><D><E><A><E><E><V><S><L><I><S><C><D><T><C><S><L><I><I><E><L><L><H><Y><N> | Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).<BOP> | Q6P3W2 |
P36941 | TNR3_HUMAN | Tumor necrosis factor receptor type III | Homo | <M><L><L><P><W><A><T><S><A><P><G><L><A><W><G><P><L><V><L><G><L><F><G><L><L><A><A><S><Q><P><Q><A><V><P><P><Y><A><S><E><N><Q><T><C><R><D><Q><E><K><E><Y><Y><E><P><Q><H><R><I><C><C><S><R><C><P><P><G><T><Y><V><S><A><K><C><S><R><I><R><D><T><V><C><A><T><C><A><E><N><S><Y><N><E><H><W><N><Y><L><T><I><C><Q><L><C><R><P><C><D><P><V><M><G><L><E><E><I><A><P><C><T><S><K><R><K><T><Q><C><R><C><Q><P><G><M><F><C><A><A><W><A><L><E><C><T><H><C><E><L><L><S><D><C><P><P><G><T><E><A><E><L><K><D><E><V><G><K><G><N><N><H><C><V><P><C><K><A><G><H><F><Q><N><T><S><S><P><S><A><R><C><Q><P><H><T><R><C><E><N><Q><G><L><V><E><A><A><P><G><T><A><Q><S><D><T><T><C><K><N><P><L><E><P><L><P><P><E><M><S><G><T><M><L><M><L><A><V><L><L><P><L><A><F><F><L><L><L><A><T><V><F><S><C><I><W><K><S><H><P><S><L><C><R><K><L><G><S><L><L><K><R><R><P><Q><G><E><G><P><N><P><V><A><G><S><W><E><P><P><K><A><H><P><Y><F><P><D><L><V><Q><P><L><L><P><I><S><G><D><V><S><P><V><S><T><G><L><P><A><A><P><V><L><E><A><G><V><P><Q><Q><Q><S><P><L><D><L><T><R><E><P><Q><L><E><P><G><E><Q><S><Q><V><A><H><G><T><N><G><I><H><V><T><G><G><S><M><T><I><T><G><N><I><Y><I><Y><N><G><P><V><L><G><G><P><P><G><P><G><D><L><P><A><T><P><E><P><P><Y><P><I><P><E><E><G><D><P><G><P><P><G><L><S><T><P><H><Q><E><D><G><K><A><W><H><L><A><E><T><E><H><C><G><A><T><P><S><N><R><G><P><R><N><Q><F><I><T><H><D> | Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.<BOP> | P36941 |
P62685 | GAK8_HUMAN | HERV-K_8p23.1 provirus ancestral Gag polyprotein | Homo | <M><G><Q><T><K><S><K><I><K><S><K><Y><A><S><Y><L><S><F><I><K><I><L><L><K><R><G><G><V><K><V><S><T><K><N><L><I><K><L><F><Q><I><I><E><Q><F><C><P><W><F><P><E><Q><G><T><L><D><L><K><D><W><K><R><I><G><K><E><L><K><Q><A><G><R><K><G><N><I><I><P><L><T><V><W><N><D><W><A><I><I><K><A><A><L><E><P><F><Q><T><E><E><D><S><I><S><V><S><D><A><P><G><S><C><L><I><D><C><N><E><N><T><R><K><K><S><Q><K><E><T><E><S><L><H><C><E><Y><V><A><E><P><V><M><A><Q><S><T><Q><N><V><D><Y><N><Q><L><Q><E><V><I><Y><P><E><T><L><K><L><E><G><K><G><P><E><L><V><G><P><S><E><S><K><P><R><G><T><S><P><L><P><A><G><Q><V><P><V><T><L><Q><P><Q><K><Q><V><K><E><N><K><T><Q><P><P><V><A><Y><Q><Y><W><P><P><A><E><L><Q><Y><R><P><P><P><E><S><Q><Y><G><Y><P><G><M><P><P><A><P><Q><G><R><E><P><Y><P><Q><P><P><T><R><R><L><N><P><T><A><P><P><S><R><Q><G><S><E><L><H><E><I><I><D><K><S><R><K><E><G><D><T><E><A><W><Q><F><P><V><T><L><E><P><M><P><P><G><E><G><A><Q><E><G><E><P><P><T><V><E><A><R><Y><K><S><F><S><I><K><M><L><K><D><M><K><E><G><V><K><Q><Y><G><P><N><S><P><Y><M><R><T><L><L><D><S><I><A><H><G><H><R><L><I><P><Y><D><W><E><I><L><A><K><S><S><L><S><P><S><Q><F><L><Q><F><K><T><W><W><I><D><G><V><Q><E><Q><V><R><R><N><R><A><A><N><P><P><V><N><I><D><A><D><Q><L><L><G><I><G><Q><N><W><S><T><I><S><Q><Q><A><L><M><Q><N><E><A><I><E><Q><V><R><A><I><C><L><R><A><W><E><K><I><Q><D><P><G><S><T><C><P><S><F><N><T><V><R><Q><G><S><K><E><P><Y><P><D><F><V><A><R><L><Q><D><V><A><Q><K><S><I><A><D><E><K><A><R><K><V><I><V><E><L><M><A><Y><E><N><A><N><P><E><C><Q><S><A><I><K><P><L><K><G><K><V><P><A><G><S><D><V><I><S><E><Y><V><K><A><C><D><G><I><G><G><A><M><H><K><A><M><L><M><A><Q><A><I><T><G><V><V><L><G><G><Q><V><R><T><F><G><G><K><C><Y><N><C><G><Q><I><G><H><L><K><K><N><C><P><V><L><N><K><Q><N><I><T><I><Q><A><T><T><T><G><R><E><P><P><D><L><C><P><R><C><K><K><G><K><H><W><A><S><Q><C><R><S><K><F><D><K><N><G><Q><P><L><S><G><N><E><Q><R><G><Q><P><Q><A><P><Q><Q><T><G><A><F><P><I><Q><P><F><V><P><Q><G><F><Q><D><N><N><P><H><C><P><K><C><F><R><E> | The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.<BOP> | P62685 |
P32298 | GRK4_HUMAN | ITI1 | Homo | <M><E><L><E><N><I><V><A><N><S><L><L><L><K><A><R><Q><G><G><Y><G><K><K><S><G><R><S><K><K><W><K><E><I><L><T><L><P><P><V><S><Q><C><S><E><L><R><H><S><I><E><K><D><Y><S><S><L><C><D><K><Q><P><I><G><R><R><L><F><R><Q><F><C><D><T><K><P><T><L><K><R><H><I><E><F><L><D><A><V><A><E><Y><E><V><A><D><D><E><D><R><S><D><C><G><L><S><I><L><D><R><F><F><N><D><K><L><A><A><P><L><P><E><I><P><P><D><V><V><T><E><C><R><L><G><L><K><E><E><N><P><S><K><K><A><F><E><E><C><T><R><V><A><H><N><Y><L><R><G><E><P><F><E><E><Y><Q><E><S><S><Y><F><S><Q><F><L><Q><W><K><W><L><E><R><Q><P><V><T><K><N><T><F><R><H><Y><R><V><L><G><K><G><G><F><G><E><V><C><A><C><Q><V><R><A><T><G><K><M><Y><A><C><K><K><L><Q><K><K><R><I><K><K><R><K><G><E><A><M><A><L><N><E><K><R><I><L><E><K><V><Q><S><R><F><V><V><S><L><A><Y><A><Y><E><T><K><D><A><L><C><L><V><L><T><I><M><N><G><G><D><L><K><F><H><I><Y><N><L><G><N><P><G><F><D><E><Q><R><A><V><F><Y><A><A><E><L><C><C><G><L><E><D><L><Q><R><E><R><I><V><Y><R><D><L><K><P><E><N><I><L><L><D><D><R><G><H><I><R><I><S><D><L><G><L><A><T><E><I><P><E><G><Q><R><V><R><G><R><V><G><T><V><G><Y><M><A><P><E><V><V><N><N><E><K><Y><T><F><S><P><D><W><W><G><L><G><C><L><I><Y><E><M><I><Q><G><H><S><P><F><K><K><Y><K><E><K><V><K><W><E><E><V><D><Q><R><I><K><N><D><T><E><E><Y><S><E><K><F><S><E><D><A><K><S><I><C><R><M><L><L><T><K><N><P><S><K><R><L><G><C><R><G><E><G><A><A><G><V><K><Q><H><P><V><F><K><D><I><N><F><R><R><L><E><A><N><M><L><E><P><P><F><C><P><D><P><H><A><V><Y><C><K><D><V><L><D><I><E><Q><F><S><V><V><K><G><I><Y><L><D><T><A><D><E><D><F><Y><A><R><F><A><T><G><C><V><S><I><P><W><Q><N><E><M><I><E><S><G><C><F><K><D><I><N><K><S><E><S><E><E><A><L><P><L><D><L><D><K><N><I><H><T><P><V><S><R><P><N><R><G><F><F><Y><R><L><F><R><R><G><G><C><L><T><M><V><P><S><E><K><E><V><E><P><K><Q><C> | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.<BOP> | P32298 |
Q969X5 | ERGI1_HUMAN | ER-Golgi intermediate compartment 32 kDa protein | Homo | <M><P><F><D><F><R><R><F><D><I><Y><R><K><V><P><K><D><L><T><Q><P><T><Y><T><G><A><I><I><S><I><C><C><C><L><F><I><L><F><L><F><L><S><E><L><T><G><F><I><T><T><E><V><V><N><E><L><Y><V><D><D><P><D><K><D><S><G><G><K><I><D><V><S><L><N><I><S><L><P><N><L><H><C><E><L><V><G><L><D><I><Q><D><E><M><G><R><H><E><V><G><H><I><D><N><S><M><K><I><P><L><N><N><G><A><G><C><R><F><E><G><Q><F><S><I><N><K><V><P><G><N><F><H><V><S><T><H><S><A><T><A><Q><P><Q><N><P><D><M><T><H><V><I><H><K><L><S><F><G><D><T><L><Q><V><Q><N><I><H><G><A><F><N><A><L><G><G><A><D><R><L><T><S><N><P><L><A><S><H><D><Y><I><L><K><I><V><P><T><V><Y><E><D><K><S><G><K><Q><R><Y><S><Y><Q><Y><T><V><A><N><K><E><Y><V><A><Y><S><H><T><G><R><I><I><P><A><I><W><F><R><Y><D><L><S><P><I><T><V><K><Y><T><E><R><R><Q><P><L><Y><R><F><I><T><T><I><C><A><I><I><G><G><T><F><T><V><A><G><I><L><D><S><C><I><F><T><A><S><E><A><W><K><K><I><Q><L><G><K><M><H> | Possible role in transport between endoplasmic reticulum and Golgi.<BOP> | Q969X5 |
Q6UXX9 | RSPO2_HUMAN | Roof plate-specific spondin-2 | Homo | <M><Q><F><R><L><F><S><F><A><L><I><I><L><N><C><M><D><Y><S><H><C><Q><G><N><R><W><R><R><S><K><R><A><S><Y><V><S><N><P><I><C><K><G><C><L><S><C><S><K><D><N><G><C><S><R><C><Q><Q><K><L><F><F><F><L><R><R><E><G><M><R><Q><Y><G><E><C><L><H><S><C><P><S><G><Y><Y><G><H><R><A><P><D><M><N><R><C><A><R><C><R><I><E><N><C><D><S><C><F><S><K><D><F><C><T><K><C><K><V><G><F><Y><L><H><R><G><R><C><F><D><E><C><P><D><G><F><A><P><L><E><E><T><M><E><C><V><E><G><C><E><V><G><H><W><S><E><W><G><T><C><S><R><N><N><R><T><C><G><F><K><W><G><L><E><T><R><T><R><Q><I><V><K><K><P><V><K><D><T><I><L><C><P><T><I><A><E><S><R><R><C><K><M><T><M><R><H><C><P><G><G><K><R><T><P><K><A><K><E><K><R><N><K><K><K><K><R><K><L><I><E><R><A><Q><E><Q><H><S><V><F><L><A><T><D><R><A><N><Q> | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway . During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form .<BOP> | Q6UXX9 |
Q8N183 | NDUF2_HUMAN | NDUFA12-like protein | Homo | <M><G><W><S><Q><D><L><F><R><A><L><W><R><S><L><S><R><E><V><K><E><H><V><G><T><D><Q><F><G><N><K><Y><Y><Y><I><P><Q><Y><K><N><W><R><G><Q><T><I><R><E><K><R><I><V><E><A><A><N><K><K><E><V><D><Y><E><A><G><D><I><P><T><E><W><E><A><W><I><R><R><T><R><K><T><P><P><T><M><E><E><I><L><K><N><E><K><H><R><E><E><I><K><I><K><S><Q><D><F><Y><E><K><E><K><L><L><S><K><E><T><S><E><E><L><L><P><P><P><V><Q><T><Q><I><K><G><H><A><S><A><P><Y><F><G><K><E><E><P><S><V><A><P><S><S><T><G><K><T><F><Q><P><G><S><W><M><P><R><D><G><K><S><H><N><Q> | Acts as a molecular chaperone for mitochondrial complex I assembly . Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone .<BOP> | Q8N183 |
Q8WU17 | RN139_HUMAN | Translocation in renal carcinoma on chromosome 8 protein | Homo | <M><A><A><V><G><P><P><Q><Q><Q><V><R><M><A><H><Q><Q><V><W><A><A><L><E><V><A><L><R><V><P><C><L><Y><I><I><D><A><I><F><N><S><Y><P><D><S><S><Q><S><R><F><C><I><V><L><Q><I><F><L><R><L><F><G><V><F><A><S><S><I><V><L><I><L><S><Q><R><S><L><F><K><F><Y><T><Y><S><S><A><F><L><L><A><A><T><S><V><L><V><N><Y><Y><A><S><L><H><I><D><F><Y><G><A><Y><N><T><S><A><F><G><I><E><L><L><P><R><K><G><P><S><L><W><M><A><L><I><V><L><Q><L><T><F><G><I><G><Y><V><T><L><L><Q><I><H><S><I><Y><S><Q><L><I><I><L><D><L><L><V><P><V><I><G><L><I><T><E><L><P><L><H><I><R><E><T><L><L><F><T><S><S><L><I><L><T><L><N><T><V><F><V><L><A><V><K><L><K><W><F><Y><Y><S><T><R><Y><V><Y><L><L><V><R><H><M><Y><R><I><Y><G><L><Q><L><L><M><E><D><T><W><K><R><I><R><F><P><D><I><L><R><V><F><W><L><T><R><V><T><A><Q><A><T><V><L><M><Y><I><L><R><M><A><N><E><T><D><S><F><F><I><S><W><D><D><F><W><D><L><I><C><N><L><I><I><S><G><C><D><S><T><L><T><V><L><G><M><S><A><V><I><S><S><V><A><H><Y><L><G><L><G><I><L><A><F><I><G><S><T><E><E><D><D><R><R><L><G><F><V><A><P><V><L><F><F><I><L><A><L><Q><T><G><L><S><G><L><R><P><E><E><R><L><I><R><L><S><R><N><M><C><L><L><L><T><A><V><L><H><F><I><H><G><M><T><D><P><V><L><M><S><L><S><A><S><H><V><S><S><F><R><R><H><F><P><V><L><F><V><S><A><C><L><F><I><L><P><V><L><L><S><Y><V><L><W><H><H><Y><A><L><N><T><W><L><F><A><V><T><A><F><C><V><E><L><C><L><K><V><I><V><S><L><T><V><Y><T><L><F><M><I><D><G><Y><Y><N><V><L><W><E><K><L><D><D><Y><V><Y><Y><V><R><S><T><G><S><I><I><E><F><I><F><G><V><V><M><F><G><N><G><A><Y><T><M><M><F><E><S><G><S><K><I><R><A><F><M><M><C><L><H><A><Y><F><N><I><Y><L><Q><A><K><N><G><W><K><T><F><M><N><R><R><T><A><V><K><K><I><N><S><L><P><E><I><K><G><S><R><L><Q><E><I><N><D><V><C><A><I><C><Y><H><E><F><T><T><S><A><R><I><T><P><C><N><H><Y><F><H><A><L><C><L><R><K><W><L><Y><I><Q><D><T><C><P><M><C><H><Q><K><V><Y><I><E><D><D><I><K><D><N><S><N><V><S><N><N><N><G><F><I><P><P><N><E><T><P><E><E><A><V><R><E><A><A><A><E><S><D><R><E><L><N><E><D><D><S><T><D><C><D><D><D><V><Q><R><E><R><N><G><V><I><Q><H><T><G><A><A><A><E><E><F><N><D><D><T><D> | E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death . Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) . Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression . Involved in the sterol-accelerated degradation of HMGCR . This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane . In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR . The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction . Required for INSIG1 ubiquitination . May be required for EIF3 complex ubiquitination .<BOP> | Q8WU17 |
Q4G0M1 | ERFE_HUMAN | Myonectin | Homo | <M><A><P><A><R><R><P><A><G><A><R><L><L><L><V><Y><A><G><L><L><A><A><A><A><A><G><L><G><S><P><E><P><G><A><P><S><R><S><R><A><R><R><E><P><P><P><G><N><E><L><P><R><G><P><G><E><S><R><A><G><P><A><A><R><P><P><E><P><T><A><E><R><A><H><S><V><D><P><R><D><A><W><M><L><F><V><R><Q><S><D><K><G><V><N><G><K><K><R><S><R><G><K><A><K><K><L><K><F><G><L><P><G><P><P><G><P><P><G><P><Q><G><P><P><G><P><I><I><P><P><E><A><L><L><K><E><F><Q><L><L><L><K><G><A><V><R><Q><R><E><R><A><E><P><E><P><C><T><C><G><P><A><G><P><V><A><A><S><L><A><P><V><S><A><T><A><G><E><D><D><D><D><V><V><G><D><V><L><A><L><L><A><A><P><L><A><P><G><P><R><A><P><R><V><E><A><A><F><L><C><R><L><R><R><D><A><L><V><E><R><R><A><L><H><E><L><G><V><Y><Y><L><P><D><A><E><G><A><F><R><R><G><P><G><L><N><L><T><S><G><Q><Y><R><A><P><V><A><G><F><Y><A><L><A><A><T><L><H><V><A><L><G><E><P><P><R><R><G><P><P><R><P><R><D><H><L><R><L><L><I><C><I><Q><S><R><C><Q><R><N><A><S><L><E><A><I><M><G><L><E><S><S><S><E><L><F><T><I><S><V><N><G><V><L><Y><L><Q><M><G><Q><W><T><S><V><F><L><D><N><A><S><G><C><S><L><T><V><R><S><G><S><H><F><S><A><V><L><L><G><V> | Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake.<BOP> | Q4G0M1 |
O14735 | CDIPT_HUMAN | Phosphatidylinositol synthase | Homo | <M><P><D><E><N><I><F><L><F><V><P><N><L><I><G><Y><A><R><I><V><F><A><I><I><S><F><Y><F><M><P><C><C><P><L><T><A><S><S><F><Y><L><L><S><G><L><L><D><A><F><D><G><H><A><A><R><A><L><N><Q><G><T><R><F><G><A><M><L><D><M><L><T><D><R><C><S><T><M><C><L><L><V><N><L><A><L><L><Y><P><G><A><T><L><F><F><Q><I><S><M><S><L><D><V><A><S><H><W><L><H><L><H><S><S><V><V><R><G><S><E><S><H><K><M><I><D><L><S><G><N><P><V><L><R><I><Y><Y><T><S><R><P><A><L><F><T><L><C><A><G><N><E><L><F><Y><C><L><L><Y><L><F><H><F><S><E><G><P><L><V><G><S><V><G><L><F><R><M><G><L><W><V><T><A><P><I><A><L><L><K><S><L><I><S><V><I><H><L><I><T><A><A><R><N><M><A><A><L><D><A><A><D><R><A><K><K><K> | Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.<BOP> | O14735 |
P35325 | SPR2B_HUMAN | Small proline-rich protein 2B | Homo | <M><S><Y><Q><Q><Q><Q><C><K><Q><P><C><Q><P><P><P><V><C><P><T><P><K><C><P><E><P><C><P><P><P><K><C><P><E><P><C><P><P><P><K><C><P><Q><P><C><P><P><Q><Q><C><Q><Q><K><Y><P><P><V><T><P><S><P><P><C><Q><P><K><Y><P><P><K><S><K> | Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.<BOP> | P35325 |
O15392 | BIRC5_HUMAN | Apoptosis inhibitor survivin | Homo | <M><G><A><P><T><L><P><P><A><W><Q><P><F><L><K><D><H><R><I><S><T><F><K><N><W><P><F><L><E><G><C><A><C><T><P><E><R><M><A><E><A><G><F><I><H><C><P><T><E><N><E><P><D><L><A><Q><C><F><F><C><F><K><E><L><E><G><W><E><P><D><D><D><P><I><E><E><H><K><K><H><S><S><G><C><A><F><L><S><V><K><K><Q><F><E><E><L><T><L><G><E><F><L><K><L><D><R><E><R><A><K><N><K><I><A><K><E><T><N><N><K><K><K><E><F><E><E><T><A><K><K><V><R><R><A><I><E><Q><L><A><A><M><D> | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis . Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis . Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules . Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis . The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules . May counteract a default induction of apoptosis in G2/M phase . The acetylated form represses STAT3 transactivation of target gene promoters . May play a role in neoplasia . Inhibitor of CASP3 and CASP7 . Essential for the maintenance of mitochondrial integrity and function . Isoform 2 and isoform 3 do not appear to play vital roles in mit | O15392 |
O00141 | SGK1_HUMAN | Serum/glucocorticoid-regulated kinase 1 | Homo | <M><T><V><K><T><E><A><A><K><G><T><L><T><Y><S><R><M><R><G><M><V><A><I><L><I><A><F><M><K><Q><R><R><M><G><L><N><D><F><I><Q><K><I><A><N><N><S><Y><A><C><K><H><P><E><V><Q><S><I><L><K><I><S><Q><P><Q><E><P><E><L><M><N><A><N><P><S><P><P><P><S><P><S><Q><Q><I><N><L><G><P><S><S><N><P><H><A><K><P><S><D><F><H><F><L><K><V><I><G><K><G><S><F><G><K><V><L><L><A><R><H><K><A><E><E><V><F><Y><A><V><K><V><L><Q><K><K><A><I><L><K><K><K><E><E><K><H><I><M><S><E><R><N><V><L><L><K><N><V><K><H><P><F><L><V><G><L><H><F><S><F><Q><T><A><D><K><L><Y><F><V><L><D><Y><I><N><G><G><E><L><F><Y><H><L><Q><R><E><R><C><F><L><E><P><R><A><R><F><Y><A><A><E><I><A><S><A><L><G><Y><L><H><S><L><N><I><V><Y><R><D><L><K><P><E><N><I><L><L><D><S><Q><G><H><I><V><L><T><D><F><G><L><C><K><E><N><I><E><H><N><S><T><T><S><T><F><C><G><T><P><E><Y><L><A><P><E><V><L><H><K><Q><P><Y><D><R><T><V><D><W><W><C><L><G><A><V><L><Y><E><M><L><Y><G><L><P><P><F><Y><S><R><N><T><A><E><M><Y><D><N><I><L><N><K><P><L><Q><L><K><P><N><I><T><N><S><A><R><H><L><L><E><G><L><L><Q><K><D><R><T><K><R><L><G><A><K><D><D><F><M><E><I><K><S><H><V><F><F><S><L><I><N><W><D><D><L><I><N><K><K><I><T><P><P><F><N><P><N><V><S><G><P><N><D><L><R><H><F><D><P><E><F><T><E><E><P><V><P><N><S><I><G><K><S><P><D><S><V><L><V><T><A><S><V><K><E><A><A><E><A><F><L><G><F><S><Y><A><P><P><T><D><S><F><L> | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, | O00141 |
Q9NPC4 | A4GAT_HUMAN | UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase | Homo | <M><S><K><P><P><D><L><L><L><R><L><L><R><G><A><P><R><Q><R><V><C><T><L><F><I><I><G><F><K><F><T><F><F><V><S><I><M><I><Y><W><H><V><V><G><E><P><K><E><K><G><Q><L><Y><N><L><P><A><E><I><P><C><P><T><L><T><P><P><T><P><P><S><H><G><P><T><P><G><N><I><F><F><L><E><T><S><D><R><T><N><P><N><F><L><F><M><C><S><V><E><S><A><A><R><T><H><P><E><S><H><V><L><V><L><M><K><G><L><P><G><G><N><A><S><L><P><R><H><L><G><I><S><L><L><S><C><F><P><N><V><Q><M><L><P><L><D><L><R><E><L><F><R><D><T><P><L><A><D><W><Y><A><A><V><Q><G><R><W><E><P><Y><L><L><P><V><L><S><D><A><S><R><I><A><L><M><W><K><F><G><G><I><Y><L><D><T><D><F><I><V><L><K><N><L><R><N><L><T><N><V><L><G><T><Q><S><R><Y><V><L><N><G><A><F><L><A><F><E><R><R><H><E><F><M><A><L><C><M><R><D><F><V><D><H><Y><N><G><W><I><W><G><H><Q><G><P><Q><L><L><T><R><V><F><K><K><W><C><S><I><R><S><L><A><E><S><R><A><C><R><G><V><T><T><L><P><P><E><A><F><Y><P><I><P><W><Q><D><W><K><K><Y><F><E><D><I><N><P><E><E><L><P><R><L><L><S><A><T><Y><A><V><H><V><W><N><K><K><S><Q><G><T><R><F><E><A><T><S><R><A><L><L><A><Q><L><H><A><R><Y><C><P><T><T><H><E><A><M><K><M><Y><L> | (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins.<BOP> | Q9NPC4 |
O75564 | JERKY_HUMAN | Jerky protein homolog | Homo | <M><A><S><K><P><A><A><G><K><S><R><G><E><K><R><K><R><V><V><L><T><L><K><E><K><I><D><I><C><T><R><L><E><K><G><E><S><R><K><A><L><M><Q><E><Y><N><V><G><M><S><T><L><Y><D><I><R><A><H><K><A><Q><L><L><R><F><F><A><S><S><D><S><N><K><A><L><E><Q><R><R><T><L><H><T><P><K><L><E><H><L><D><R><V><L><Y><E><W><F><L><G><K><R><S><E><G><V><P><V><S><G><P><M><L><I><E><K><A><K><D><F><Y><E><Q><M><Q><L><T><E><P><C><V><F><S><G><G><W><L><W><R><F><K><A><R><H><G><I><K><K><L><D><A><S><S><E><K><Q><S><A><D><H><Q><A><A><E><Q><F><C><A><F><F><R><S><L><A><A><E><H><G><L><S><A><E><Q><V><Y><N><A><D><E><T><G><L><F><W><R><C><L><P><N><P><T><P><E><G><G><A><V><P><G><P><K><Q><G><K><D><R><L><T><V><L><M><C><A><N><A><T><G><S><H><R><L><K><P><L><A><I><G><K><C><S><G><P><R><A><F><K><G><I><Q><H><L><P><V><A><Y><K><A><Q><G><N><A><W><V><D><K><E><I><F><S><D><W><F><H><H><I><F><V><P><S><V><R><E><H><F><R><T><I><G><L><P><E><D><S><K><A><V><L><L><L><D><S><S><R><A><H><P><Q><E><A><E><L><V><S><S><N><V><F><T><I><F><L><P><A><S><V><A><S><L><V><Q><P><M><E><Q><G><I><R><R><D><F><M><R><N><F><I><N><P><P><V><P><L><Q><G><P><H><A><R><Y><N><M><N><D><A><I><F><S><V><A><C><A><W><N><A><V><P><S><H><V><F><R><R><A><W><R><K><L><W><P><S><V><A><F><A><E><G><S><S><S><E><E><E><L><E><A><E><C><F><P><V><K><P><H><N><K><S><F><A><H><I><L><E><L><V><K><E><G><S><S><C><P><G><Q><L><R><Q><R><Q><A><A><S><W><G><V><A><G><R><E><A><E><G><G><R><P><P><A><A><T><S><P><A><E><V><V><W><S><S><E><K><T><P><K><A><D><Q><D><G><R><G><D><P><G><E><G><E><E><V><A><W><E><Q><A><A><V><A><F><D><A><V><L><R><F><A><E><R><Q><P><C><F><S><A><Q><E><V><G><Q><L><R><A><L><R><A><V><F><R><S><Q><Q><Q><E><T><V><G><L><E><D><V><V><V><T><S><P><E><E><L><A><I><P><K><C><C><L><E><A><S><T><E><T> | May bind DNA.<BOP> | O75564 |
Q8N682 | DRAM1_HUMAN | Damage-regulated autophagy modulator | Homo | <M><L><C><F><L><R><G><M><A><F><V><P><F><L><L><V><T><W><S><S><A><A><F><I><I><S><Y><V><V><A><V><L><S><G><H><V><N><P><F><L><P><Y><I><S><D><T><G><T><T><P><P><E><S><G><I><F><G><F><M><I><N><F><S><A><F><L><G><A><A><T><M><Y><T><R><Y><K><I><V><Q><K><Q><N><Q><T><C><Y><F><S><T><P><V><F><N><L><V><S><L><V><L><G><L><V><G><C><F><G><M><G><I><V><A><N><F><Q><E><L><A><V><P><V><V><H><D><G><G><A><L><L><A><F><V><C><G><V><V><Y><T><L><L><Q><S><I><I><S><Y><K><S><C><P><Q><W><N><S><L><S><T><C><H><I><R><M><V><I><S><A><V><S><C><A><A><V><I><P><M><I><V><C><A><S><L><I><S><I><T><K><L><E><W><N><P><R><E><K><D><Y><V><Y><H><V><V><S><A><I><C><E><W><T><V><A><F><G><F><I><F><Y><F><L><T><F><I><Q><D><F><Q><S><V><T><L><R><I><S><T><E><I><N><G><D><I> | Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.<BOP> | Q8N682 |
Q96AP4 | ZUP1_HUMAN | Zinc finger with UFM1-specific peptidase domain protein | Homo | <M><L><S><C><N><I><C><G><E><T><V><T><S><E><P><D><M><K><A><H><L><I><V><H><M><E><S><E><I><I><C><P><F><C><K><L><S><G><V><N><Y><D><E><M><C><F><H><I><E><T><A><H><F><E><Q><N><T><L><E><R><N><F><E><R><I><N><T><V><Q><Y><G><T><S><D><N><K><K><D><N><T><L><Q><C><G><M><E><V><N><S><S><I><L><S><G><C><A><S><N><H><P><K><N><S><A><Q><N><L><T><K><D><S><T><L><K><H><E><G><F><Y><S><E><N><L><T><E><S><R><K><F><L><K><S><R><E><K><Q><S><S><L><T><E><I><K><G><S><V><Y><E><T><T><Y><S><P><P><E><C><P><F><C><G><K><I><E><E><H><S><E><D><M><E><T><H><V><K><T><K><H><A><N><L><L><D><I><P><L><E><D><C><D><Q><P><L><Y><D><C><P><M><C><G><L><I><C><T><N><Y><H><I><L><Q><E><H><V><D><L><H><L><E><E><N><S><F><Q><Q><G><M><D><R><V><Q><C><S><G><D><L><Q><L><A><H><Q><L><Q><Q><E><E><D><R><K><R><R><S><E><E><S><R><Q><E><I><E><E><F><Q><K><L><Q><R><Q><Y><G><L><D><N><S><G><G><Y><K><Q><Q><Q><L><R><N><M><E><I><E><V><N><R><G><R><M><P><P><S><E><F><H><R><R><K><A><D><M><M><E><S><L><A><L><G><F><D><D><G><K><T><K><T><S><G><I><I><E><A><L><H><R><Y><Y><Q><N><A><A><T><D><V><R><R><V><W><L><S><S><V><V><D><H><F><H><S><S><L><G><D><K><G><W><G><C><G><Y><R><N><F><Q><M><L><L><S><S><L><L><Q><N><D><A><Y><N><D><C><L><K><G><M><L><I><P><C><I><P><K><I><Q><S><M><I><E><D><A><W><K><E><G><F><D><P><Q><G><A><S><Q><L><N><N><R><L><Q><G><T><K><A><W><I><G><A><C><E><V><Y><I><L><L><T><S><L><R><V><K><C><H><I><V><D><F><H><K><S><T><G><P><L><G><T><H><P><R><L><F><E><W><I><L><N><Y><Y><S><S><E><G><E><G><S><P><K><V><V><C><T><S><K><P><P><I><Y><L><Q><H><Q><G><H><S><R><T><V><I><G><I><E><E><K><K><N><R><T><L><C><L><L><I><L><D><P><G><C><P><S><R><E><M><Q><K><L><L><K><Q><D><I><E><A><S><S><L><K><Q><L><R><K><S><M><G><N><L><K><H><K><Q><Y><Q><I><L><A><V><E><G><A><L><S><L><E><E><K><L><A><R><R><Q><A><S><Q><V><F><T><A><E><K><I><P> | Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains . Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage . Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress .<BOP> | Q96AP4 |
O60826 | CCD22_HUMAN | Coiled-coil domain-containing protein 22 | Homo | <M><E><E><A><D><R><I><L><I><H><S><L><R><Q><A><G><T><A><V><P><P><D><V><Q><T><L><R><A><F><T><T><E><L><V><V><E><A><V><V><R><C><L><R><V><I><N><P><A><V><G><S><G><L><S><P><L><L><P><L><A><M><S><A><R><F><R><L><A><M><S><L><A><Q><A><C><M><D><L><G><Y><P><L><E><L><G><Y><Q><N><F><L><Y><P><S><E><P><D><L><R><D><L><L><L><F><L><A><E><R><L><P><T><D><A><S><E><D><A><D><Q><P><A><G><D><S><A><I><L><L><R><A><I><G><S><Q><I><R><D><Q><L><A><L><P><W><V><P><P><H><L><R><T><P><K><L><Q><H><L><Q><G><S><A><L><Q><K><P><F><H><A><S><R><L><V><V><P><E><L><S><S><R><G><E><P><R><E><F><Q><A><S><P><L><L><L><P><V><P><T><Q><V><P><Q><P><V><G><R><V><A><S><L><L><E><H><H><A><L><Q><L><C><Q><Q><T><G><R><D><R><P><G><D><E><D><W><V><H><R><T><S><R><L><P><P><Q><E><D><T><R><A><Q><R><Q><R><L><Q><K><Q><L><T><E><H><L><R><Q><S><W><G><L><L><G><A><P><I><Q><A><R><D><L><G><E><L><L><Q><A><W><G><A><G><A><K><T><G><A><P><K><G><S><R><F><T><H><S><E><K><F><T><F><H><L><E><P><Q><A><Q><A><T><Q><V><S><D><V><P><A><T><S><R><R><P><E><Q><V><T><W><A><A><Q><E><Q><E><L><E><S><L><R><E><Q><L><E><G><V><N><R><S><I><E><E><V><E><A><D><M><K><T><L><G><V><S><F><V><Q><A><E><S><E><C><R><H><S><K><L><S><T><A><E><R><E><Q><A><L><R><L><K><S><R><A><V><E><L><L><P><D><G><T><A><N><L><A><K><L><Q><L><V><V><E><N><S><A><Q><R><V><I><H><L><A><G><Q><W><E><K><H><R><V><P><L><L><A><E><Y><R><H><L><R><K><L><Q><D><C><R><E><L><E><S><S><R><R><L><A><E><I><Q><E><L><H><Q><S><V><R><A><A><A><E><E><A><R><R><K><E><E><V><Y><K><Q><L><M><S><E><L><E><T><L><P><R><D><V><S><R><L><A><Y><T><Q><R><I><L><E><I><V><G><N><I><R><K><Q><K><E><E><I><T><K><I><L><S><D><T><K><E><L><Q><K><E><I><N><S><L><S><G><K><L><D><R><T><F><A><V><T><D><E><L><V><F><K><D><A><K><K><D><D><A><V><R><K><A><Y><K><Y><L><A><A><L><H><E><N><C><S><Q><L><I><Q><T><I><E><D><T><G><T><I><M><R><E><V><R><D><L><E><E><Q><I><E><T><E><L><G><K><K><T><L><S><N><L><E><K><I><R><E><D><Y><R><A><L><R><Q><E><N><A><G><L><L><G><R><V><R><E><A> | (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.<BOP> | O60826 |
P55316 | FOXG1_HUMAN | Forkhead-related protein FKHL3 | Homo | <M><L><D><M><G><D><R><K><E><V><K><M><I><P><K><S><S><F><S><I><N><S><L><V><P><E><A><V><Q><N><D><N><H><H><A><S><H><G><H><H><N><S><H><H><P><Q><H><H><H><H><H><H><H><H><H><H><H><P><P><P><P><A><P><Q><P><P><P><P><P><Q><Q><Q><Q><P><P><P><P><P><P><P><A><P><Q><P><P><Q><T><R><G><A><P><A><A><D><D><D><K><G><P><Q><Q><L><L><L><P><P><P><P><P><P><P><P><A><A><A><L><D><G><A><K><A><D><G><L><G><G><K><G><E><P><G><G><G><P><G><E><L><A><P><V><G><P><D><E><K><E><K><G><A><G><A><G><G><E><E><K><K><G><A><G><E><G><G><K><D><G><E><G><G><K><E><G><E><K><K><N><G><K><Y><E><K><P><P><F><S><Y><N><A><L><I><M><M><A><I><R><Q><S><P><E><K><R><L><T><L><N><G><I><Y><E><F><I><M><K><N><F><P><Y><Y><R><E><N><K><Q><G><W><Q><N><S><I><R><H><N><L><S><L><N><K><C><F><V><K><V><P><R><H><Y><D><D><P><G><K><G><N><Y><W><M><L><D><P><S><S><D><D><V><F><I><G><G><T><T><G><K><L><R><R><R><S><T><T><S><R><A><K><L><A><F><K><R><G><A><R><L><T><S><T><G><L><T><F><M><D><R><A><G><S><L><Y><W><P><M><S><P><F><L><S><L><H><H><P><R><A><S><S><T><L><S><Y><N><G><T><T><S><A><Y><P><S><H><P><M><P><Y><S><S><V><L><T><Q><N><S><L><G><N><N><H><S><F><S><T><A><N><G><L><S><V><D><R><L><V><N><G><E><I><P><Y><A><T><H><H><L><T><A><A><A><L><A><A><S><V><P><C><G><L><S><V><P><C><S><G><T><Y><S><L><N><P><C><S><V><N><L><L><A><G><Q><T><S><Y><F><F><P><H><V><P><H><P><S><M><T><S><Q><S><S><T><S><M><S><A><R><A><A><S><S><S><T><S><P><Q><A><P><S><T><L><P><C><E><S><L><R><P><S><L><P><S><F><T><T><G><L><S><G><G><L><S><D><Y><F><T><H><Q><N><Q><G><S><S><S><N><P><L><I><H> | Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.<BOP> | P55316 |
Q9UD71 | PPR1B_HUMAN | Dopamine- and cAMP-regulated neuronal phosphoprotein | Homo | <M><D><P><K><D><R><K><K><I><Q><F><S><V><P><A><P><P><S><Q><L><D><P><R><Q><V><E><M><I><R><R><R><R><P><T><P><A><M><L><F><R><L><S><E><H><S><S><P><E><E><E><A><S><P><H><Q><R><A><S><G><E><G><H><H><L><K><S><K><R><P><N><P><C><A><Y><T><P><P><S><L><K><A><V><Q><R><I><A><E><S><H><L><Q><S><I><S><N><L><N><E><N><Q><A><S><E><E><E><D><E><L><G><E><L><R><E><L><G><Y><P><R><E><E><D><E><E><E><E><E><D><D><E><E><E><E><E><E><E><D><S><Q><A><E><V><L><K><V><I><R><Q><S><A><G><Q><K><T><T><C><G><Q><G><L><E><G><P><W><E><R><P><P><P><L><D><E><S><E><R><D><G><G><S><E><D><Q><V><E><D><P><A><L><S><E><P><G><E><E><P><Q><R><P><S><P><S><E><P><G><T> | Inhibitor of protein-phosphatase 1.<BOP> | Q9UD71 |
A0A0B4J277 | TVA22_HUMAN | T cell receptor alpha variable 22 | Homo | <M><K><R><I><L><G><A><L><L><G><L><L><S><A><Q><V><C><C><V><R><G><I><Q><V><E><Q><S><P><P><D><L><I><L><Q><E><G><A><N><S><T><L><R><C><N><F><S><D><S><V><N><N><L><Q><W><F><H><Q><N><P><W><G><Q><L><I><N><L><F><Y><I><P><S><G><T><K><Q><N><G><R><L><S><A><T><T><V><A><T><E><R><Y><S><L><L><Y><I><S><S><S><Q><T><T><D><S><G><V><Y><F><C><A><V><E> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0B4J277 |
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