accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q8ND83
SLAI1_HUMAN
SLAIN motif-containing protein 1
Homo
<M><M><A><E><Q><V><K><C><A><S><A><G><V><S><S><G><A><G><S><G><P><V><V><N><A><E><L><E><V><K><K><L><Q><E><L><V><R><K><L><E><K><Q><N><E><Q><L><R><S><R><A><A><S><A><A><A><A><P><H><L><L><L><L><P><P><P><P><P><A><A><P><P><P><A><G><L><Q><P><L><G><P><R><S><P><P><A><A><T><A><T><A><A><A><S><G><G><L><G><P><A><F><P><G><T><F><C><L><P><S><P><A><P><S><L><L><C><S><L><A><Q><P><P><E><A><P><F><V><Y><F><K><P><A><A><G><F><F><G><A><G><G><G><G><P><E><P><G><G><A><G><T><P><P><G><A><A><A><A><P><P><S><P><P><P><T><L><L><D><E><V><E><L><L><D><L><E><S><V><A><A><W><R><D><E><D><D><Y><T><W><L><Y><I><G><S><S><K><T><F><T><S><S><E><K><S><L><T><P><L><Q><W><C><R><H><V><L><D><N><P><T><P><E><M><E><A><A><R><R><S><L><C><F><R><L><E><Q><G><Y><T><S><R><G><S><P><L><S><P><Q><S><S><I><D><S><E><L><S><T><S><E><L><E><D><D><S><I><S><M><G><Y><K><L><Q><D><L><T><D><V><Q><I><M><A><R><L><Q><E><E><S><L><R><Q><D><Y><A><S><T><S><A><S><V><S><R><H><S><S><S><V><S><L><S><S><G><K><K><G><T><C><S><D><Q><E><Y><D><Q><Y><S><L><E><D><E><E><E><F><D><H><L><P><P><P><Q><P><R><L><P><R><C><S><P><F><Q><R><G><I><P><H><S><Q><T><F><S><S><I><R><E><C><R><R><S><P><S><S><Q><Y><F><P><S><N><N><Y><Q><Q><Q><Q><Y><Y><S><P><Q><A><Q><T><P><D><Q><Q><P><N><R><T><N><G><D><K><L><R><R><S><M><P><N><L><A><R><M><P><S><T><T><A><I><S><S><N><I><S><S><P><V><T><V><R><N><S><Q><S><F><D><S><S><L><H><G><A><G><N><G><I><S><R><I><Q><S><C><I><P><S><P><G><Q><L><Q><H><R><V><H><S><V><G><H><F><P><V><S><I><R><Q><P><L><K><A><T><A><Y><V><S><P><T><V><Q><G><S><S><N><M><P><L><S><N><G><L><Q><L><Y><S><N><T><G><I><P><T><P><N><K><A><A><A><S><G><I><M><G><R><S><A><L><P><R><P><S><L><A><I><N><G><S><N><L><P><R><S><K><I><A><Q><P><V><R><S><F><L><Q><P><P><K><P><L><S><S><L><S><T><L><R><D><G><N><W><R><D><G><C><Y>
Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation.<BOP>
Q8ND83
P78396
CCNA1_HUMAN
Cyclin-A1
Homo
<M><E><T><G><F><P><A><I><M><Y><P><G><S><F><I><G><G><W><G><E><E><Y><L><S><W><E><G><P><G><L><P><D><F><V><F><Q><Q><Q><P><V><E><S><E><A><M><H><C><S><N><P><K><S><G><V><V><L><A><T><V><A><R><G><P><D><A><C><Q><I><L><T><R><A><P><L><G><Q><D><P><P><Q><R><T><V><L><G><L><L><T><A><N><G><Q><Y><R><R><T><C><G><Q><G><I><T><R><I><R><C><Y><S><G><S><E><N><A><F><P><P><A><G><K><K><A><L><P><D><C><G><V><Q><E><P><P><K><Q><G><F><D><I><Y><M><D><E><L><E><Q><G><D><R><D><S><C><S><V><R><E><G><M><A><F><E><D><V><Y><E><V><D><T><G><T><L><K><S><D><L><H><F><L><L><D><F><N><T><V><S><P><M><L><V><D><S><S><L><L><S><Q><S><E><D><I><S><S><L><G><T><D><V><I><N><V><T><E><Y><A><E><E><I><Y><Q><Y><L><R><E><A><E><I><R><H><R><P><K><A><H><Y><M><K><K><Q><P><D><I><T><E><G><M><R><T><I><L><V><D><W><L><V><E><V><G><E><E><Y><K><L><R><A><E><T><L><Y><L><A><V><N><F><L><D><R><F><L><S><C><M><S><V><L><R><G><K><L><Q><L><V><G><T><A><A><M><L><L><A><S><K><Y><E><E><I><Y><P><P><E><V><D><E><F><V><Y><I><T><D><D><T><Y><T><K><R><Q><L><L><K><M><E><H><L><L><L><K><V><L><A><F><D><L><T><V><P><T><T><N><Q><F><L><L><Q><Y><L><R><R><Q><G><V><C><V><R><T><E><N><L><A><K><Y><V><A><E><L><S><L><L><E><A><D><P><F><L><K><Y><L><P><S><L><I><A><A><A><A><F><C><L><A><N><Y><T><V><N><K><H><F><W><P><E><T><L><A><A><F><T><G><Y><S><L><S><E><I><V><P><C><L><S><E><L><H><K><A><Y><L><D><I><P><H><R><P><Q><Q><A><I><R><E><K><Y><K><A><S><K><Y><L><C><V><S><L><M><E><P><P><A><V><L><L><L><Q>
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.<BOP>
P78396
Q96FJ0
STALP_HUMAN
STAM-binding protein-like 1
Homo
<M><D><Q><P><F><T><V><N><S><L><K><K><L><A><A><M><P><D><H><T><D><V><S><L><S><P><E><E><R><V><R><A><L><S><K><L><G><C><N><I><T><I><S><E><D><I><T><P><R><R><Y><F><R><S><G><V><E><M><E><R><M><A><S><V><Y><L><E><E><G><N><L><E><N><A><F><V><L><Y><N><K><F><I><T><L><F><V><E><K><L><P><N><H><R><D><Y><Q><Q><C><A><V><P><E><K><Q><D><I><M><K><K><L><K><E><I><A><F><P><R><T><D><E><L><K><N><D><L><L><K><K><Y><N><V><E><Y><Q><E><Y><L><Q><S><K><N><K><Y><K><A><E><I><L><K><K><L><E><H><Q><R><L><I><E><A><E><R><K><R><I><A><Q><M><R><Q><Q><Q><L><E><S><E><Q><F><L><F><F><E><D><Q><L><K><K><Q><E><L><A><R><G><Q><M><R><S><Q><Q><T><S><G><L><S><E><Q><I><D><G><S><A><L><S><C><F><S><T><H><Q><N><N><S><L><L><N><V><F><A><D><Q><P><N><K><S><D><A><T><N><Y><A><S><H><S><P><P><V><N><R><A><L><T><P><A><A><T><L><S><A><V><Q><N><L><V><V><E><G><L><R><C><V><V><L><P><E><D><L><C><H><K><F><L><Q><L><A><E><S><N><T><V><R><G><I><E><T><C><G><I><L><C><G><K><L><T><H><N><E><F><T><I><T><H><V><I><V><P><K><Q><S><A><G><P><D><Y><C><D><M><E><N><V><E><E><L><F><N><V><Q><D><Q><H><D><L><L><T><L><G><W><I><H><T><H><P><T><Q><T><A><F><L><S><S><V><D><L><H><T><H><C><S><Y><Q><L><M><L><P><E><A><I><A><I><V><C><S><P><K><H><K><D><T><G><I><F><R><L><T><N><A><G><M><L><E><V><S><A><C><K><K><K><G><F><H><P><H><T><K><E><P><R><L><F><S><I><C><K><H><V><L><V><K><D><I><K><I><I><V><L><D><L><R>
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains . Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex . Does not cleave 'Lys-48'-linked polyubiquitin chains .<BOP>
Q96FJ0
P0C604
OR4A8_HUMAN
Olfactory receptor OR11-110
Homo
<M><R><Q><N><N><N><I><T><E><F><V><L><L><G><F><S><Q><Y><P><D><V><Q><N><A><L><F><V><M><F><L><L><I><Y><I><V><T><M><V><G><N><L><L><I><V><V><S><I><I><A><S><P><F><L><G><S><P><V><Y><F><F><L><A><C><L><S><F><I><D><A><V><Y><S><T><T><I><S><P><V><L><I><V><D><L><L><C><D><K><K><T><I><S><F><P><A><C><M><G><Q><L><F><I><E><H><L><F><G><D><T><D><V><F><L><L><V><V><M><A><Y><D><R><Y><V><A><T><C><K><P><L><R><Y><L><T><I><M><N><R><Q><V><C><I><L><L><L><V><V><A><V><T><G><G><F><L><H><S><V><F><Q><I><L><V><V><Y><S><L><P><F><C><G><P><N><V><I><Y><H><F><F><C><N><I><Y><P><L><L><D><L><E><C><T><D><T><Y><F><V><G><L><A><V><V><F><N><G><G><A><I><C><M><V><I><F><T><L><L><L><I><S><Y><G><V><I><L><N><S><L><K><T><Y><S><P><E><G><R><H><K><A><P><F><I><C><S><S><H><F><I><M><V><I><L><F><F><V><P><C><I><F><L><Y><V><R><P><V><S><N><F><P><I><D><K><F><L><T><V><F><Y><S><V><I><T><P><K><L><N><P><F><I><Y><M><L><R><N><S><E><M><R><N><A><I><E><N><L><L><G><Y><Q><S><G><K><T><G><F><R><C><S><K><L><N>
Odorant receptor.<BOP>
P0C604
Q6NX45
ZN774_HUMAN
Zinc finger protein 774
Homo
<M><W><L><G><T><S><G><K><S><G><L><P><G><H><C><L><E><N><P><L><Q><E><C><H><P><A><Q><L><E><E><W><A><L><K><G><I><S><R><P><S><V><I><S><Q><P><E><Q><K><E><E><P><W><V><L><P><L><Q><N><F><E><A><R><K><I><P><R><E><S><H><T><D><C><E><H><Q><V><A><K><L><N><Q><D><N><S><E><T><A><E><Q><C><G><T><S><S><E><R><T><N><K><D><L><S><H><T><L><S><W><G><G><N><W><E><Q><G><L><E><L><E><G><Q><H><G><T><L><P><G><E><G><Q><L><E><S><F><S><Q><E><R><D><L><N><K><L><L><D><G><Y><V><G><E><K><P><M><C><A><E><C><G><K><S><F><N><Q><S><S><Y><L><I><R><H><L><R><T><H><T><G><E><R><P><Y><T><C><I><E><C><G><K><G><F><K><Q><S><S><D><L><V><T><H><R><R><T><H><T><G><E><K><P><Y><Q><C><K><G><C><E><K><K><F><S><D><S><S><T><L><I><K><H><Q><R><T><H><T><G><E><R><P><Y><E><C><P><E><C><G><K><T><F><G><R><K><P><H><L><I><M><H><Q><R><T><H><T><G><E><K><P><Y><A><C><L><E><C><H><K><S><F><S><R><S><S><N><F><I><T><H><Q><R><T><H><T><G><V><K><P><Y><R><C><N><D><C><G><E><S><F><S><Q><S><S><D><L><I><K><H><Q><R><T><H><T><G><E><R><P><F><K><C><P><E><C><G><K><G><F><R><D><S><S><H><F><V><A><H><M><S><T><H><S><G><E><R><P><F><S><C><P><D><C><H><K><S><F><S><Q><S><S><H><L><V><T><H><Q><R><T><H><T><G><E><R><P><F><K><C><E><N><C><G><K><G><F><A><D><S><S><A><L><I><K><H><Q><R><I><H><T><G><E><R><P><Y><K><C><G><E><C><G><K><S><F><N><Q><S><S><H><F><I><T><H><Q><R><I><H><L><G><D><R><P><Y><R><C><P><E><C><G><K><T><F><N><Q><R><S><H><F><L><T><H><Q><R><T><H><T><G><E><K><P><F><H><C><S><K><C><N><K><S><F><R><Q><K><A><H><L><L><C><H><Q><N><T><H><L><I>
May be involved in transcriptional regulation.<BOP>
Q6NX45
P01374
TNFB_HUMAN
Tumor necrosis factor ligand superfamily member 1
Homo
<M><T><P><P><E><R><L><F><L><P><R><V><C><G><T><T><L><H><L><L><L><L><G><L><L><L><V><L><L><P><G><A><Q><G><L><P><G><V><G><L><T><P><S><A><A><Q><T><A><R><Q><H><P><K><M><H><L><A><H><S><T><L><K><P><A><A><H><L><I><G><D><P><S><K><Q><N><S><L><L><W><R><A><N><T><D><R><A><F><L><Q><D><G><F><S><L><S><N><N><S><L><L><V><P><T><S><G><I><Y><F><V><Y><S><Q><V><V><F><S><G><K><A><Y><S><P><K><A><T><S><S><P><L><Y><L><A><H><E><V><Q><L><F><S><S><Q><Y><P><F><H><V><P><L><L><S><S><Q><K><M><V><Y><P><G><L><Q><E><P><W><L><H><S><M><Y><H><G><A><A><F><Q><L><T><Q><G><D><Q><L><S><T><H><T><D><G><I><P><H><L><V><L><S><P><S><T><V><F><F><G><A><F><A><L>
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM . In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.<BOP>
P01374
O95278
EPM2A_HUMAN
Lafora PTPase
Homo
<M><R><F><R><F><G><V><V><V><P><P><A><V><A><G><A><R><P><E><L><L><V><V><G><S><R><P><E><L><G><R><W><E><P><R><G><A><V><R><L><R><P><A><G><T><A><A><G><D><G><A><L><A><L><Q><E><P><G><L><W><L><G><E><V><E><L><A><A><E><E><A><A><Q><D><G><A><E><P><G><R><V><D><T><F><W><Y><K><F><L><K><R><E><P><G><G><E><L><S><W><E><G><N><G><P><H><H><D><R><C><C><T><Y><N><E><N><N><L><V><D><G><V><Y><C><L><P><I><G><H><W><I><E><A><T><G><H><T><N><E><M><K><H><T><T><D><F><Y><F><N><I><A><G><H><Q><A><M><H><Y><S><R><I><L><P><N><I><W><L><G><S><C><P><R><Q><V><E><H><V><T><I><K><L><K><H><E><L><G><I><T><A><V><M><N><F><Q><T><E><W><D><I><V><Q><N><S><S><G><C><N><R><Y><P><E><P><M><T><P><D><T><M><I><K><L><Y><R><E><E><G><L><A><Y><I><W><M><P><T><P><D><M><S><T><E><G><R><V><Q><M><L><P><Q><A><V><C><L><L><H><A><L><L><E><K><G><H><I><V><Y><V><H><C><N><A><G><V><G><R><S><T><A><A><V><C><G><W><L><Q><Y><V><M><G><W><N><L><R><K><V><Q><Y><F><L><M><A><K><R><P><A><V><Y><I><D><E><E><A><L><A><R><A><Q><E><D><F><F><Q><K><F><G><K><V><R><S><S><V><C><S><L>
Has phosphatase activity (in vitro).<BOP>
O95278
Q8N2H4
SYS1_HUMAN
Protein SYS1 homolog
Homo
<M><A><G><Q><F><R><S><Y><V><W><D><P><L><L><I><L><S><Q><I><V><L><M><Q><T><V><Y><Y><G><S><L><G><L><W><L><A><L><V><D><G><L><V><R><S><S><P><S><L><D><Q><M><F><D><A><E><I><L><G><F><S><T><P><P><G><R><L><S><M><M><S><F><I><L><N><A><L><T><C><A><L><G><L><L><Y><F><I><R><R><G><K><Q><C><L><D><F><T><V><T><V><H><F><F><H><L><L><G><C><W><F><Y><S><S><R><F><P><S><A><L><T><W><W><L><V><Q><A><V><C><I><A><L><M><A><V><I><G><E><Y><L><C><M><R><T><E><L><K><E><I><P><L><N><S><A><P><K><S><N><V>
Involved in protein trafficking. May serve as a receptor for ARFRP1.<BOP>
Q8N2H4
Q68DY1
ZN626_HUMAN
Zinc finger protein 626
Homo
<M><G><P><L><Q><F><R><D><V><A><I><E><F><S><L><E><E><W><H><C><L><D><T><A><Q><R><N><L><Y><R><N><V><M><L><E><N><Y><S><N><L><V><F><L><G><I><T><V><S><K><P><D><L><I><T><C><L><E><Q><G><R><K><P><L><T><M><K><R><N><E><M><I><A><K><P><S><V><M><C><S><H><F><A><Q><D><L><W><P><E><Q><S><M><K><D><S><F><Q><K><V><V><L><R><R><Y><E><K><C><E><H><D><N><L><Q><L><K><K><G><C><I><S><V><D><E><C><K><V><H><K><E><G><Y><N><E><L><N><Q><C><L><T><T><T><P><R><K><I><C><Q><C><D><K><Y><V><K><V><L><H><Q><F><P><N><S><N><G><Q><K><R><G><H><T><G><K><K><P><F><K><Y><I><E><C><G><K><A><F><K><Q><F><S><T><L><T><T><H><K><K><I><H><T><G><G><K><P><Y><K><C><E><E><C><G><K><A><F><N><H><S><C><S><L><T><R><H><K><K><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><H><S><S><T><L><T><T><H><K><R><N><H><T><G><E><K><P><Y><K><C><D><K><C><G><K><A><F><M><S><S><S><T><L><S><K><H><E><I><I><H><T><E><K><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><T><L><T><T><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><D><K><A><F><K><Y><S><Y><T><L><T><T><H><K><R><I><H><T><E><D><K><P><Y><K><C><E><E><C><G><K><A><F><K><Y><S><S><T><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><D><L><T><T><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><Y><S><S><N><L><T><T><H><K><K><I><H><T><G><E><R><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><I><L><T><T><H><R><R><I><H><T><G><E><K><F><Y><K><C><E><E><C><G><K><A><F><K><C><S><S><N><L><T><T><H><K><K><I><H><T><G><E><R><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><I><L><T><T><H><E><R><I><I><L><E><R><N><S><T><N><V><K><N><V><A><K><P><S><S><G><P><H><T><L><L><H><I><R>
May be involved in transcriptional regulation.<BOP>
Q68DY1
Q00597
FANCC_HUMAN
Fanconi anemia group C protein
Homo
<M><A><Q><D><S><V><D><L><S><C><D><Y><Q><F><W><M><Q><K><L><S><V><W><D><Q><A><S><T><L><E><T><Q><Q><D><T><C><L><H><V><A><Q><F><Q><E><F><L><R><K><M><Y><E><A><L><K><E><M><D><S><N><T><V><I><E><R><F><P><T><I><G><Q><L><L><A><K><A><C><W><N><P><F><I><L><A><Y><D><E><S><Q><K><I><L><I><W><C><L><C><C><L><I><N><K><E><P><Q><N><S><G><Q><S><K><L><N><S><W><I><Q><G><V><L><S><H><I><L><S><A><L><R><F><D><K><E><V><A><L><F><T><Q><G><L><G><Y><A><P><I><D><Y><Y><P><G><L><L><K><N><M><V><L><S><L><A><S><E><L><R><E><N><H><L><N><G><F><N><T><Q><R><R><M><A><P><E><R><V><A><S><L><S><R><V><C><V><P><L><I><T><L><T><D><V><D><P><L><V><E><A><L><L><I><C><H><G><R><E><P><Q><E><I><L><Q><P><E><F><F><E><A><V><N><E><A><I><L><L><K><K><I><S><L><P><M><S><A><V><V><C><L><W><L><R><H><L><P><S><L><E><K><A><M><L><H><L><F><E><K><L><I><S><S><E><R><N><C><L><R><R><I><E><C><F><I><K><D><S><S><L><P><Q><A><A><C><H><P><A><I><F><R><V><V><D><E><M><F><R><C><A><L><L><E><T><D><G><A><L><E><I><I><A><T><I><Q><V><F><T><Q><C><F><V><E><A><L><E><K><A><S><K><Q><L><R><F><A><L><K><T><Y><F><P><Y><T><S><P><S><L><A><M><V><L><L><Q><D><P><Q><D><I><P><R><G><H><W><L><Q><T><L><K><H><I><S><E><L><L><R><E><A><V><E><D><Q><T><H><G><S><C><G><G><P><F><E><S><W><F><L><F><I><H><F><G><G><W><A><E><M><V><A><E><Q><L><L><M><S><A><A><E><P><P><T><A><L><L><W><L><L><A><F><Y><Y><G><P><R><D><G><R><Q><Q><R><A><Q><T><M><V><Q><V><K><A><V><L><G><H><L><L><A><M><S><R><S><S><S><L><S><A><Q><D><L><Q><T><V><A><G><Q><G><T><D><T><D><L><R><A><P><A><Q><Q><L><I><R><H><L><L><L><N><F><L><L><W><A><P><G><G><H><T><I><A><W><D><V><I><T><L><M><A><H><T><A><E><I><T><H><E><I><I><G><F><L><D><Q><T><L><Y><R><W><N><R><L><G><I><E><S><P><R><S><E><K><L><A><R><E><L><L><K><E><L><R><T><Q><V>
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.<BOP>
Q00597
Q96BN2
TADA1_HUMAN
Transcriptional adapter 1-like protein
Homo
<M><A><T><F><V><S><E><L><E><A><A><K><K><N><L><S><E><A><L><G><D><N><V><K><Q><Y><W><A><N><L><K><L><W><F><K><Q><K><I><S><K><E><E><F><D><L><E><A><H><R><L><L><T><Q><D><N><V><H><S><H><N><D><F><L><L><A><I><L><T><R><C><Q><I><L><V><S><T><P><D><G><A><G><S><L><P><W><P><G><G><S><A><A><K><P><G><K><P><K><G><K><K><K><L><S><S><V><R><Q><K><F><D><H><R><F><Q><P><Q><N><P><L><S><G><A><Q><Q><F><V><A><K><D><P><Q><D><D><D><D><L><K><L><C><S><H><T><M><M><L><P><T><R><G><Q><L><E><G><R><M><I><V><T><A><Y><E><H><G><L><D><N><V><T><E><E><A><V><S><A><V><V><Y><A><V><E><N><H><L><K><D><I><L><T><S><V><V><S><R><R><K><A><Y><R><L><R><D><G><H><F><K><Y><A><F><G><S><N><V><T><P><Q><P><Y><L><K><N><S><V><V><A><Y><N><N><L><I><E><S><P><P><A><F><T><A><P><C><A><G><Q><N><P><A><S><H><P><P><P><D><D><A><E><Q><Q><A><A><L><L><L><A><C><S><G><D><T><L><P><A><S><L><P><P><V><N><M><Y><D><L><F><E><A><L><Q><V><H><R><E><V><I><P><T><H><T><V><Y><A><L><N><I><E><R><I><I><T><K><L><W><H><P><N><H><E><E><L><Q><Q><D><K><V><H><R><Q><R><L><A><A><K><E><G><L><L><L><C>
Probably involved in transcriptional regulation.<BOP>
Q96BN2
Q9GZK7
O11A1_HUMAN
Olfactory receptor OR6-30
Homo
<M><E><I><V><S><T><G><N><E><T><I><T><E><F><V><L><L><G><F><Y><D><I><P><E><L><H><F><L><F><F><I><V><F><T><A><V><Y><V><F><I><I><I><G><N><M><L><I><I><V><A><V><V><S><S><Q><R><L><H><K><P><M><Y><I><F><L><A><N><L><S><F><L><D><I><L><Y><T><S><A><V><M><P><K><M><L><E><G><F><L><Q><E><A><T><I><S><V><A><G><C><L><L><Q><F><F><I><F><G><S><L><A><T><A><E><C><L><L><L><A><V><M><A><Y><D><R><Y><L><A><I><C><Y><P><L><H><Y><P><L><L><M><G><P><R><R><Y><M><G><L><V><V><T><T><W><L><S><G><F><V><V><D><G><L><V><V><A><L><V><A><Q><L><R><F><C><G><P><N><H><I><D><Q><F><Y><C><D><F><M><L><F><V><G><L><A><C><S><D><P><R><V><A><Q><V><T><T><L><I><L><S><V><F><C><L><T><I><P><F><G><L><I><L><T><S><Y><A><R><I><V><V><A><V><L><R><V><P><A><G><A><S><R><R><R><A><F><S><T><C><S><S><H><L><A><V><V><T><T><F><Y><G><T><L><M><I><F><Y><V><A><P><S><A><V><H><S><Q><L><L><S><K><V><F><S><L><L><Y><T><V><V><T><P><L><F><N><P><V><I><Y><T><M><R><N><K><E><V><H><Q><A><L><R><K><I><L><C><I><K><Q><T><E><T><L><D>
Odorant receptor.<BOP>
Q9GZK7
Q6ZMW2
ZN782_HUMAN
Zinc finger protein 782
Homo
<M><N><T><F><Q><A><S><V><S><F><Q><D><V><T><V><E><F><S><Q><E><E><W><Q><H><M><G><P><V><E><R><T><L><Y><R><D><V><M><L><E><N><Y><S><H><L><V><S><V><G><Y><C><F><T><K><P><E><L><I><F><T><L><E><Q><G><E><D><P><W><L><L><E><K><E><K><G><F><L><S><R><N><S><P><E><D><S><Q><P><D><E><I><S><E><K><S><P><E><N><Q><G><K><H><L><L><Q><V><L><F><T><N><K><L><L><T><T><E><Q><E><I><S><G><K><P><H><N><R><D><I><N><I><F><R><A><R><M><M><P><C><K><C><D><I><A><G><S><A><C><Q><G><L><S><L><M><A><P><H><C><Q><Y><S><K><E><K><A><H><E><R><N><V><C><D><K><W><L><I><S><I><K><D><G><R><T><N><T><Q><E><K><S><F><A><Y><S><K><I><V><K><T><L><H><H><K><E><E><V><I><Q><H><Q><T><I><Q><T><L><G><Q><D><F><E><Y><N><E><S><R><K><A><F><L><E><K><A><A><L><V><T><S><N><S><T><H><P><K><G><K><S><Y><N><F><N><K><F><G><E><N><K><Y><D><K><S><T><F><I><I><P><Q><N><M><N><P><E><K><S><H><Y><E><F><N><D><T><G><N><C><F><C><R><I><T><H><K><T><L><T><G><G><K><S><F><S><Q><K><S><H><I><R><E><H><H><R><V><H><I><G><V><K><P><F><E><Y><G><K><S><F><N><R><N><S><T><L><P><V><H><Q><R><T><H><A><T><D><K><Y><S><D><Y><H><P><C><T><E><T><F><S><Y><Q><S><T><F><S><V><H><Q><K><V><H><I><R><A><K><P><Y><E><Y><N><E><C><G><K><S><C><S><M><N><S><H><L><I><W><P><Q><K><S><H><T><G><E><K><P><Y><E><C><P><E><C><G><K><A><F><S><E><K><S><R><L><R><K><H><Q><R><T><H><T><G><E><K><P><Y><K><C><D><G><C><D><K><A><F><S><A><K><S><G><L><R><I><H><Q><R><T><H><T><G><E><K><P><F><E><C><H><E><C><G><K><S><F><N><Y><K><S><I><L><I><V><H><Q><R><T><H><T><G><E><K><P><F><E><C><N><E><C><G><K><S><F><S><H><M><S><G><L><R><N><H><R><R><T><H><T><G><E><R><P><Y><K><C><D><E><C><G><K><A><F><K><L><K><S><G><L><R><K><H><H><R><T><H><T><G><E><K><P><Y><K><C><N><Q><C><G><K><A><F><G><Q><K><S><Q><L><R><G><H><H><R><I><H><T><G><E><K><P><Y><K><C><N><H><C><G><E><A><F><S><Q><K><S><N><L><R><V><H><H><R><T><H><T><G><E><K><P><Y><Q><C><E><E><C><G><K><T><F><R><Q><K><S><N><L><R><G><H><Q><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><E><K><S><V><L><R><K><H><Q><R><T><H><T><G><E><K><P><Y><N><C><N><Q><C><G><E><A><F><S><Q><K><S><N><L><R><V><H><Q><R><T><H><T><G><E><K><P><Y><K><C><D><K><C><G><R><T><F><S><Q><K><S><S><L><R><E><H><Q><K><A><H><P><G><D>
May be involved in transcriptional regulation.<BOP>
Q6ZMW2
S4R3P1
HMN13_HUMAN
MT-RNR2-like protein 13
Homo
<M><D><T><Q><G><F><S><C><L><L><L><L><I><S><E><I><D><L><S><V><K><R><R><I>
Plays a role as a neuroprotective and antiapoptotic factor.<BOP>
S4R3P1
Q99946
PRRT1_HUMAN
Synapse differentiation-induced protein 4
Homo
<M><S><S><E><K><S><G><L><P><D><S><V><P><H><T><S><P><P><P><Y><N><A><P><Q><P><P><A><E><P><P><A><P><P><P><Q><A><A><P><S><S><H><H><H><H><H><H><H><Y><H><Q><S><G><T><A><T><L><P><R><L><G><A><G><G><L><A><S><S><A><A><T><A><Q><R><G><P><S><S><S><A><T><L><P><R><P><P><H><H><A><P><P><G><P><A><A><G><A><P><P><P><G><C><A><T><L><P><R><M><P><P><D><P><Y><L><Q><E><T><R><F><E><G><P><L><P><P><P><P><P><A><A><A><A><P><P><P><P><A><P><A><Q><T><A><Q><A><P><G><F><V><V><P><T><H><A><G><T><V><G><T><L><P><L><G><G><Y><V><A><P><G><Y><P><L><Q><L><Q><P><C><T><A><Y><V><P><V><Y><P><V><G><T><P><Y><A><G><G><T><P><G><G><T><G><V><T><S><T><L><P><P><P><P><Q><G><P><G><L><A><L><L><E><P><R><R><P><P><H><D><Y><M><P><I><A><V><L><T><T><I><C><C><F><W><P><T><G><I><I><A><I><F><K><A><V><Q><V><R><T><A><L><A><R><G><D><M><V><S><A><E><I><A><S><R><E><A><R><N><F><S><F><I><S><L><A><V><G><I><A><A><M><V><L><C><T><I><L><T><V><V><I><I><I><A><A><Q><H><H><E><N><Y><W><D><P>
Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression.<BOP>
Q99946
P20591
MX1_HUMAN
Interferon-induced GTP-binding protein Mx1, N-terminally processed
Homo
<M><V><V><S><E><V><D><I><A><K><A><D><P><A><A><A><S><H><P><L><L><L><N><G><D><A><T><V><A><Q><K><N><P><G><S><V><A><E><N><N><L><C><S><Q><Y><E><E><K><V><R><P><C><I><D><L><I><D><S><L><R><A><L><G><V><E><Q><D><L><A><L><P><A><I><A><V><I><G><D><Q><S><S><G><K><S><S><V><L><E><A><L><S><G><V><A><L><P><R><G><S><G><I><V><T><R><C><P><L><V><L><K><L><K><K><L><V><N><E><D><K><W><R><G><K><V><S><Y><Q><D><Y><E><I><E><I><S><D><A><S><E><V><E><K><E><I><N><K><A><Q><N><A><I><A><G><E><G><M><G><I><S><H><E><L><I><T><L><E><I><S><S><R><D><V><P><D><L><T><L><I><D><L><P><G><I><T><R><V><A><V><G><N><Q><P><A><D><I><G><Y><K><I><K><T><L><I><K><K><Y><I><Q><R><Q><E><T><I><S><L><V><V><V><P><S><N><V><D><I><A><T><T><E><A><L><S><M><A><Q><E><V><D><P><E><G><D><R><T><I><G><I><L><T><K><P><D><L><V><D><K><G><T><E><D><K><V><V><D><V><V><R><N><L><V><F><H><L><K><K><G><Y><M><I><V><K><C><R><G><Q><Q><E><I><Q><D><Q><L><S><L><S><E><A><L><Q><R><E><K><I><F><F><E><N><H><P><Y><F><R><D><L><L><E><E><G><K><A><T><V><P><C><L><A><E><K><L><T><S><E><L><I><T><H><I><C><K><S><L><P><L><L><E><N><Q><I><K><E><T><H><Q><R><I><T><E><E><L><Q><K><Y><G><V><D><I><P><E><D><E><N><E><K><M><F><F><L><I><D><K><V><N><A><F><N><Q><D><I><T><A><L><M><Q><G><E><E><T><V><G><E><E><D><I><R><L><F><T><R><L><R><H><E><F><H><K><W><S><T><I><I><E><N><N><F><Q><E><G><H><K><I><L><S><R><K><I><Q><K><F><E><N><Q><Y><R><G><R><E><L><P><G><F><V><N><Y><R><T><F><E><T><I><V><K><Q><Q><I><K><A><L><E><E><P><A><V><D><M><L><H><T><V><T><D><M><V><R><L><A><F><T><D><V><S><I><K><N><F><E><E><F><F><N><L><H><R><T><A><K><S><K><I><E><D><I><R><A><E><Q><E><R><E><G><E><K><L><I><R><L><H><F><Q><M><E><Q><I><V><Y><C><Q><D><Q><V><Y><R><G><A><L><Q><K><V><R><E><K><E><L><E><E><E><K><K><K><K><S><W><D><F><G><A><F><Q><S><S><S><A><T><D><S><S><M><E><E><I><F><Q><H><L><M><A><Y><H><Q><E><A><S><K><R><I><S><S><H><I><P><L><I><I><Q><F><F><M><L><Q><T><Y><G><Q><Q><L><Q><K><A><M><L><Q><L><L><Q><D><K><D><T><Y><S><W><L><L><K><E><R><S><D><T><S><D><K><R><K><F><L><K><E><R><L><A><R><L><T><Q><A><R><R><R><L><A><Q><F><P><G>
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<BOP>
P20591
Q8WVF1
OSCP1_HUMAN
Oxidored-nitro domain-containing protein 1
Homo
<M><S><V><R><T><L><P><L><L><F><L><N><L><G><G><E><M><L><Y><I><L><D><Q><R><L><R><A><Q><N><I><P><G><D><K><A><R><K><D><E><W><T><E><V><D><R><K><R><V><L><N><D><I><I><S><T><M><F><N><R><K><F><M><E><E><L><F><K><P><Q><E><L><Y><S><K><K><A><L><R><T><V><Y><E><R><L><A><H><A><S><I><M><K><L><N><Q><A><S><M><D><K><L><Y><D><L><M><T><M><A><F><K><Y><Q><V><L><L><C><P><R><P><K><D><V><L><L><V><T><F><N><H><L><D><T><I><K><G><F><I><R><D><S><P><T><I><L><Q><Q><V><D><E><T><L><R><Q><L><T><E><I><Y><G><G><L><S><A><G><E><F><Q><L><I><R><Q><T><L><L><I><F><F><Q><D><L><H><I><R><V><S><M><F><L><K><D><K><V><Q><N><N><N><G><R><F><V><L><P><V><S><G><P><V><P><W><G><T><E><V><P><G><L><I><R><M><F><N><N><K><G><E><E><V><K><R><I><E><F><K><H><G><G><N><Y><V><P><A><P><K><E><G><S><F><E><L><Y><G><D><R><V><L><K><L><G><T><N><M><Y><S><V><N><Q><P><V><E><T><H><V><S><G><S><S><K><N><L><A><S><W><T><Q><E><S><I><A><P><N><P><L><A><K><E><E><L><N><F><L><A><R><L><M><G><G><M><E><I><K><K><P><S><G><P><E><P><G><F><R><L><N><L><F><T><T><D><E><E><E><E><Q><A><A><L><T><R><P><E><E><L><S><Y><E><V><I><N><I><Q><A><T><Q><D><Q><Q><R><S><E><E><L><A><R><I><M><G><E><F><E><I><T><E><Q><P><R><L><S><T><S><K><G><D><D><L><L><A><M><M><D><E><L>
May be involved in drug clearance in the placenta.<BOP>
Q8WVF1
Q10469
MGAT2_HUMAN
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Homo
<M><R><F><R><I><Y><K><R><K><V><L><I><L><T><L><V><V><A><A><C><G><F><V><L><W><S><S><N><G><R><Q><R><K><N><E><A><L><A><P><P><L><L><D><A><E><P><A><R><G><A><G><G><R><G><G><D><H><P><S><V><A><V><G><I><R><R><V><S><N><V><S><A><A><S><L><V><P><A><V><P><Q><P><E><A><D><N><L><T><L><R><Y><R><S><L><V><Y><Q><L><N><F><D><Q><T><L><R><N><V><D><K><A><G><T><W><A><P><R><E><L><V><L><V><V><Q><V><H><N><R><P><E><Y><L><R><L><L><L><D><S><L><R><K><A><Q><G><I><D><N><V><L><V><I><F><S><H><D><F><W><S><T><E><I><N><Q><L><I><A><G><V><N><F><C><P><V><L><Q><V><F><F><P><F><S><I><Q><L><Y><P><N><E><F><P><G><S><D><P><R><D><C><P><R><D><L><P><K><N><A><A><L><K><L><G><C><I><N><A><E><Y><P><D><S><F><G><H><Y><R><E><A><K><F><S><Q><T><K><H><H><W><W><W><K><L><H><F><V><W><E><R><V><K><I><L><R><D><Y><A><G><L><I><L><F><L><E><E><D><H><Y><L><A><P><D><F><Y><H><V><F><K><K><M><W><K><L><K><Q><Q><E><C><P><E><C><D><V><L><S><L><G><T><Y><S><A><S><R><S><F><Y><G><M><A><D><K><V><D><V><K><T><W><K><S><T><E><H><N><M><G><L><A><L><T><R><N><A><Y><Q><K><L><I><E><C><T><D><T><F><C><T><Y><D><D><Y><N><W><D><W><T><L><Q><Y><L><T><V><S><C><L><P><K><F><W><K><V><L><V><P><Q><I><P><R><I><F><H><A><G><D><C><G><M><H><H><K><K><T><C><R><P><S><T><Q><S><A><Q><I><E><S><L><L><N><N><N><K><Q><Y><M><F><P><E><T><L><T><I><S><E><K><F><T><V><V><A><I><S><P><P><R><K><N><G><G><W><G><D><I><R><D><H><E><L><C><K><S><Y><R><R><L><Q>
Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.<BOP>
Q10469
Q9BTP6
ZBED2_HUMAN
Zinc finger BED domain-containing protein 2
Homo
<M><M><R><R><E><D><E><E><E><E><G><T><M><M><K><A><K><G><D><L><E><M><K><E><E><E><E><I><S><E><T><G><E><L><V><G><P><F><V><S><A><M><P><T><P><M><P><H><N><K><G><T><R><F><S><E><A><W><E><Y><F><H><L><A><P><A><R><A><G><H><H><P><N><Q><Y><A><T><C><R><L><C><G><R><Q><V><S><R><G><P><G><V><N><V><G><T><T><A><L><W><K><H><L><K><S><M><H><R><E><E><L><E><K><S><G><H><G><Q><A><G><Q><R><Q><D><P><R><P><H><G><P><Q><L><P><T><G><I><E><G><N><W><G><R><L><L><E><Q><V><G><T><M><A><L><W><A><S><Q><R><E><K><E><V><L><R><R><E><R><A><V><E><W><R><E><R><A><V><E><K><R><E><R><A><L><E><E><V><E><R><A><I><L><E><M><K><W><K><V><R><A><E><K><E><A><C><Q><R><E><K><E><L><P><A><A><V><H><P><F><H><F><V>
Transcriptional regulator which has intrinsic repressor activity and which competes with the transcriptional activator IRF1 for binding to the 5'-[CA]GAA[AC]C[CT]-3' consensus sequence in gene promoters . May thereby play a role in keratinocyte differentiation .<BOP>
Q9BTP6
Q8NGM1
OR4CF_HUMAN
Olfactory receptor OR11-134
Homo
<M><Q><N><Q><S><F><V><T><E><F><V><L><L><G><L><S><Q><N><P><N><V><Q><E><I><V><F><V><V><F><L><F><V><Y><I><A><T><V><G><G><N><M><L><I><V><V><T><I><L><S><S><P><A><L><L><V><S><P><M><Y><F><F><L><G><F><L><S><F><L><D><A><C><F><S><S><V><I><T><P><K><M><I><V><D><S><L><Y><V><T><K><T><I><S><F><E><G><C><M><M><Q><L><F><A><E><H><F><F><A><G><V><E><V><I><V><L><T><A><M><A><Y><D><R><Y><V><A><I><C><K><P><L><H><Y><S><S><I><M><N><R><R><L><C><G><I><L><M><G><V><A><W><T><G><G><L><L><H><S><M><I><Q><I><L><F><T><F><Q><L><P><F><C><G><P><N><V><I><N><H><F><M><C><D><L><Y><P><L><L><E><L><A><C><T><D><T><H><I><F><G><L><M><V><V><I><N><S><G><F><I><C><I><I><N><F><S><L><L><L><V><S><Y><A><V><I><L><L><S><L><R><T><H><S><S><E><G><R><W><K><A><L><S><T><C><G><S><H><I><A><V><V><I><L><F><F><V><P><C><I><F><V><Y><T><R><P><P><S><A><F><S><L><D><K><M><A><A><I><F><Y><I><I><L><N><P><L><L><N><P><L><I><Y><T><F><R><N><K><E><V><K><Q><A><M><R><R><I><W><N><R><L><M><V><V><S><D><E><K><E><N><I><K><L>
Odorant receptor.<BOP>
Q8NGM1
Q8WXF0
SRS12_HUMAN
Splicing factor, arginine/serine-rich 19
Homo
<M><S><R><Y><T><R><P><P><N><T><S><L><F><I><R><N><V><A><D><A><T><R><P><E><D><L><R><R><E><F><G><R><Y><G><P><I><V><D><V><Y><I><P><L><D><F><Y><T><R><R><P><R><G><F><A><Y><V><Q><F><E><D><V><R><D><A><E><D><A><L><Y><N><L><N><R><K><W><V><C><G><R><Q><I><E><I><Q><F><A><Q><G><D><R><K><T><P><G><Q><M><K><S><K><E><R><H><P><C><S><P><S><D><H><R><R><S><R><S><P><S><Q><R><R><T><R><S><R><S><S><S><W><G><R><N><R><R><R><S><D><S><L><K><E><S><R><H><R><R><F><S><Y><S><Q><S><K><S><R><S><K><S><L><P><R><R><S><T><S><A><R><Q><S><R><T><P><R><R><N><F><G><S><R><G><R><S><R><S><K><S><L><Q><K><R><S><K><S><I><G><K><S><Q><S><S><S><P><Q><K><Q><T><S><S><G><T><K><S><R><S><H><G><R><H><S><D><S><I><A><R><S><P><C><K><S><P><K><G><Y><T><N><S><E><T><K><V><Q><T><A><K><H><S><H><F><R><S><H><S><R><S><R><S><Y><R><H><K><N><S><W>
Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.<BOP>
Q8WXF0
Q8NCF0
CL18C_HUMAN
Mannose receptor-like protein 3
Homo
<M><L><H><P><E><T><S><P><G><R><G><H><L><L><A><V><L><L><A><L><L><G><T><A><W><A><E><V><W><P><P><Q><L><Q><E><Q><A><P><M><A><G><A><L><N><R><K><E><S><F><L><L><L><S><L><H><N><R><L><R><S><W><V><Q><P><P><A><A><D><M><R><R><L><D><W><S><D><S><L><A><Q><L><A><Q><A><R><A><A><L><C><G><I><P><T><P><S><L><A><S><G><L><W><R><T><L><Q><V><G><W><N><M><Q><L><L><P><A><G><L><A><S><F><V><E><V><V><S><L><W><F><A><E><G><Q><R><Y><S><H><A><A><G><E><C><A><R><N><A><T><C><T><H><Y><T><Q><L><V><W><A><T><S><S><Q><L><G><C><G><R><H><L><C><S><A><G><Q><A><A><I><E><A><F><V><C><A><Y><S><P><R><G><N><W><E><V><N><G><K><T><I><V><P><Y><K><K><G><A><W><C><S><L><C><T><A><S><V><S><G><C><F><K><A><W><D><H><A><G><G><L><C><E><V><P><R><N><P><C><R><M><S><C><Q><N><H><G><R><L><N><I><S><T><C><H><C><H><C><P><P><G><Y><T><G><R><Y><C><Q><V><R><C><S><L><Q><C><V><H><G><R><F><R><E><E><E><C><S><C><V><C><D><I><G><Y><G><G><A><Q><C><A><T><K><V><H><F><P><F><H><T><C><D><L><R><I><D><G><D><C><F><M><V><S><S><E><A><D><T><Y><Y><R><A><R><M><K><C><Q><R><K><G><G><V><L><A><Q><I><K><S><Q><K><V><Q><D><I><L><A><F><Y><L><G><R><L><E><T><T><N><E><V><I><D><S><D><F><E><T><R><N><F><W><I><G><L><T><Y><K><T><A><K><D><S><F><R><W><A><T><G><E><H><Q><A><F><T><S><F><A><F><G><Q><P><D><N><H><G><F><G><N><C><V><E><L><Q><A><S><A><A><F><N><W><N><N><Q><R><C><K><T><R><N><R><Y><I><C><Q><F><A><Q><E><H><I><S><R><W><G><P><G><S>
Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.<BOP>
Q8NCF0
Q9H4Z3
CAPAM_HUMAN
Protein phosphatase 1 regulatory subunit 121
Homo
<M><A><N><E><N><H><G><S><P><R><E><E><A><S><L><L><S><H><S><P><G><T><S><N><Q><S><Q><P><C><S><P><K><P><I><R><L><V><Q><D><L><P><E><E><L><V><H><A><G><W><E><K><C><W><S><R><R><E><N><R><P><Y><Y><F><N><R><F><T><N><Q><S><L><W><E><M><P><V><L><G><Q><H><D><V><I><S><D><P><L><G><L><N><A><T><P><L><P><Q><D><S><S><L><V><E><T><P><P><A><E><N><K><P><R><K><R><Q><L><S><E><E><Q><P><S><G><N><G><V><K><K><P><K><I><E><I><P><V><T><P><T><G><Q><S><V><P><S><S><P><S><I><P><G><T><P><T><L><K><M><W><G><T><S><P><E><D><K><Q><Q><A><A><L><L><R><P><T><E><V><Y><W><D><L><D><I><Q><T><N><A><V><I><K><H><R><G><P><S><E><V><L><P><P><H><P><E><V><E><L><L><R><S><Q><L><I><L><K><L><R><Q><H><Y><R><E><L><C><Q><Q><R><E><G><I><E><P><P><R><E><S><F><N><R><W><M><L><E><R><K><V><V><D><K><G><S><D><P><L><L><P><S><N><C><E><P><V><V><S><P><S><M><F><R><E><I><M><N><D><I><P><I><R><L><S><R><I><K><F><R><E><E><A><K><R><L><L><F><K><Y><A><E><A><A><R><R><L><I><E><S><R><S><A><S><P><D><S><R><K><V><V><K><W><N><V><E><D><T><F><S><W><L><R><K><D><H><S><A><S><K><E><D><Y><M><D><R><L><E><H><L><R><R><Q><C><G><P><H><V><S><A><A><A><K><D><S><V><E><G><I><C><S><K><I><Y><H><I><S><L><E><Y><V><K><R><I><R><E><K><H><L><A><I><L><K><E><N><N><I><S><E><E><V><E><A><P><E><V><E><P><R><L><V><Y><C><Y><P><V><R><L><A><V><S><A><P><P><M><P><S><V><E><M><H><M><E><N><N><V><V><C><I><R><Y><K><G><E><M><V><K><V><S><R><N><Y><F><S><K><L><W><L><L><Y><R><Y><S><C><I><D><D><S><A><F><E><R><F><L><P><R><V><W><C><L><L><R><R><Y><Q><M><M><F><G><V><G><L><Y><E><G><T><G><L><Q><G><S><L><P><V><H><V><F><E><A><L><H><R><L><F><G><V><S><F><E><C><F><A><S><P><L><N><C><Y><F><R><Q><Y><C><S><A><F><P><D><T><D><G><Y><F><G><S><R><G><P><C><L><D><F><A><P><L><S><G><S><F><E><A><N><P><P><F><C><E><E><L><M><D><A><M><V><S><H><F><E><R><L><L><E><S><S><P><E><P><L><S><F><I><V><F><I><P><E><W><R><E><P><P><T><P><A><L><T><R><M><E><Q><S><R><F><K><R><H><Q><L><I><L><P><A><F><E><H><E><Y><R><S><G><S><Q><H><I><C><K><K><E><E><M><H><Y><K><A><V><H><N><T><A><V><L><F><L><Q><N><D><P><G><F><A><K><W><A><P><T><P><E><R><L><Q><E><L><S><A><A><Y><R><Q><S><G><R><S><H><S><S><G><S><S><S><S><S><S><S><E><A><K><D><R><D><S><G><R><E><Q><G><P><S><R><E><P><H><P><T>
Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs . Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally .<BOP>
Q9H4Z3
P59103
DAOA_HUMAN
Protein G72
Homo
<M><L><E><K><L><M><G><A><D><S><L><Q><L><F><R><S><R><Y><T><L><G><K><I><Y><F><I><G><F><Q><R><S><I><L><L><S><K><S><E><N><S><L><N><S><I><A><K><E><T><E><E><G><R><E><T><V><T><R><K><E><G><W><K><R><R><H><E><D><G><Y><L><E><M><A><Q><R><H><L><Q><R><S><L><C><P><W><V><S><Y><L><P><Q><P><Y><A><E><L><E><E><V><S><S><H><V><G><K><V><F><M><A><R><N><Y><E><F><L><A><Y><E><A><S><K><D><R><R><Q><P><L><E><R><M><W><T><C><N><Y><N><Q><Q><K><D><Q><S><C><N><H><K><E><I><T><S><T><K><A><E>
Seems to activate D-amino acid oxidase.<BOP>
P59103
O00270
GPR31_HUMAN
GPR31/12-HETER
Homo
<M><P><F><P><N><C><S><A><P><S><T><V><V><A><T><A><V><G><V><L><L><G><L><E><C><G><L><G><L><L><G><N><A><V><A><L><W><T><F><L><F><R><V><R><V><W><K><P><Y><A><V><Y><L><L><N><L><A><L><A><D><L><L><L><A><A><C><L><P><F><L><A><A><F><Y><L><S><L><Q><A><W><H><L><G><R><V><G><C><W><A><L><H><F><L><L><D><L><S><R><S><V><G><M><A><F><L><A><A><V><A><L><D><R><Y><L><R><V><V><H><P><R><L><K><V><N><L><L><S><P><Q><A><A><L><G><V><S><G><L><V><W><L><L><M><V><A><L><T><C><P><G><L><L><I><S><E><A><A><Q><N><S><T><R><C><H><S><F><Y><S><R><A><D><G><S><F><S><I><I><W><Q><E><A><L><S><C><L><Q><F><V><L><P><F><G><L><I><V><F><C><N><A><G><I><I><R><A><L><Q><K><R><L><R><E><P><E><K><Q><P><K><L><Q><R><A><Q><A><L><V><T><L><V><V><V><L><F><A><L><C><F><L><P><C><F><L><A><R><V><L><M><H><I><F><Q><N><L><G><S><C><R><A><L><C><A><V><A><H><T><S><D><V><T><G><S><L><T><Y><L><H><S><V><L><N><P><V><V><Y><C><F><S><S><P><T><F><R><S><S><Y><R><R><V><F><H><T><L><R><G><K><G><Q><A><A><E><P><P><D><F><N><P><R><D><S><Y><S>
Proton-sensing G protein-coupled receptor.<BOP>
O00270
Q92874
DNSL2_HUMAN
Deoxyribonuclease I-like 2
Homo
<M><G><G><P><R><A><L><L><A><A><L><W><A><L><E><A><A><G><T><A><A><L><R><I><G><A><F><N><I><Q><S><F><G><D><S><K><V><S><D><P><A><C><G><S><I><I><A><K><I><L><A><G><Y><D><L><A><L><V><Q><E><V><R><D><P><D><L><S><A><V><S><A><L><M><E><Q><I><N><S><V><S><E><H><E><Y><S><F><V><S><S><Q><P><L><G><R><D><Q><Y><K><E><M><Y><L><F><V><Y><R><K><D><A><V><S><V><V><D><T><Y><L><Y><P><D><P><E><D><V><F><S><R><E><P><F><V><V><K><F><S><A><P><G><T><G><E><R><A><P><P><L><P><S><R><R><A><L><T><P><P><P><L><P><A><A><A><Q><N><L><V><L><I><P><L><H><A><A><P><H><Q><A><V><A><E><I><D><A><L><Y><D><V><Y><L><D><V><I><D><K><W><G><T><D><D><M><L><F><L><G><D><F><N><A><D><C><S><Y><V><R><A><Q><D><W><A><A><I><R><L><R><S><S><E><V><F><K><W><L><I><P><D><S><A><D><T><T><V><G><N><S><D><C><A><Y><D><R><I><V><A><C><G><A><R><L><R><R><S><L><K><P><Q><S><A><T><V><H><D><F><Q><E><E><F><G><L><D><Q><T><Q><A><L><A><I><S><D><H><F><P><V><E><V><T><L><K><F><H><R>
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.<BOP>
Q92874
Q9HCX3
ZN304_HUMAN
KRAB-containing zinc finger protein
Homo
<M><A><A><A><V><L><M><D><R><V><Q><S><C><V><T><F><E><D><V><F><V><Y><F><S><R><E><E><W><E><L><L><E><E><A><Q><R><F><L><Y><R><D><V><M><L><E><N><F><A><L><V><A><T><L><G><F><W><C><E><A><E><H><E><A><P><S><E><Q><S><V><S><V><E><G><V><S><Q><V><R><T><A><E><S><G><L><F><Q><K><A><H><P><C><E><M><C><D><P><L><L><K><D><I><L><H><L><A><E><H><Q><G><S><H><L><T><Q><K><L><C><T><R><G><L><C><R><R><R><F><S><F><S><A><N><F><Y><Q><H><Q><K><Q><H><N><G><E><N><C><F><R><G><D><D><G><G><A><S><F><V><K><S><C><T><V><H><M><L><G><R><S><F><T><C><R><E><E><G><M><D><L><P><D><S><S><G><L><F><Q><H><Q><T><T><Y><N><R><V><S><P><C><R><R><T><E><C><M><E><S><F><P><H><S><S><S><L><R><Q><H><Q><G><D><Y><D><G><Q><M><L><F><S><C><G><D><E><G><K><A><F><L><D><T><F><T><L><L><D><S><Q><M><T><H><A><E><V><R><P><F><R><C><L><P><C><G><N><V><F><K><E><K><S><A><L><I><N><H><R><K><I><H><S><G><E><I><S><H><V><C><K><E><C><G><K><A><F><I><H><L><H><H><L><K><M><H><Q><K><F><H><T><G><K><R><H><Y><T><C><S><E><C><G><K><A><F><S><R><K><D><T><L><V><Q><H><Q><R><V><H><T><G><E><R><S><Y><D><C><S><E><C><G><K><A><Y><S><R><S><S><H><L><V><Q><H><Q><R><I><H><T><G><E><R><P><Y><K><C><N><K><C><G><K><A><F><S><R><K><D><T><L><V><Q><H><Q><R><F><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><F><F><S><Q><S><S><H><L><I><E><H><W><R><I><H><T><G><A><R><P><Y><E><C><I><E><C><G><K><F><F><S><H><N><S><S><L><I><K><H><R><R><V><H><T><G><A><R><S><Y><V><C><S><K><C><G><K><A><F><G><C><K><D><T><L><V><Q><H><Q><I><I><H><T><G><A><R><P><Y><E><C><S><E><C><G><K><A><F><S><R><K><D><T><L><V><Q><H><Q><K><I><H><T><G><E><R><P><Y><E><C><G><E><C><G><K><F><F><S><H><S><S><N><L><I><V><H><Q><R><I><H><T><G><A><K><P><Y><E><C><N><E><C><G><K><C><F><S><H><N><S><S><L><I><L><H><Q><R><V><H><T><G><A><R><P><Y><V><C><S><E><C><G><K><A><Y><I><S><S><S><H><L><V><Q><H><K><K><V><H><T><G><A><R><P><Y><E><C><S><E><C><G><K><F><F><S><R><N><S><G><L><I><L><H><Q><R><V><H><T><G><E><K><P><Y><V><C><S><E><C><G><K><A><Y><S><R><S><S><H><L><V><R><H><Q><K><A><H><T><G><E><R><A><H><E><C><N><S><F><G><G><P><L><A><A><S><L><K><L><V>
Acts as transcriptional regulator and plays a role in gene silencing . Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites . Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways . Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression . Promotes angiogenesis . Promotes tumor growth .<BOP>
Q9HCX3
P10074
TZAP_HUMAN
Zinc finger protein 855
Homo
<M><D><G><S><F><V><Q><H><S><V><R><V><L><Q><E><L><N><K><Q><R><E><K><G><Q><Y><C><D><A><T><L><D><V><G><G><L><V><F><K><A><H><W><S><V><L><A><C><C><S><H><F><F><Q><S><L><Y><G><D><G><S><G><G><S><V><V><L><P><A><G><F><A><E><I><F><G><L><L><L><D><F><F><Y><T><G><H><L><A><L><T><S><G><N><R><D><Q><V><L><L><A><A><R><E><L><R><V><P><E><A><V><E><L><C><Q><S><F><K><P><K><T><S><V><G><Q><A><A><G><G><Q><S><G><L><G><P><P><A><S><Q><N><V><N><S><H><V><K><E><P><A><G><L><E><E><E><E><V><S><R><T><L><G><L><V><P><R><D><Q><E><P><R><G><S><H><S><P><Q><R><P><Q><L><H><S><P><A><Q><S><E><G><P><S><S><L><C><G><K><L><K><Q><A><L><K><P><C><P><L><E><D><K><K><P><E><D><C><K><V><P><P><R><P><L><E><A><E><G><A><Q><L><Q><G><G><S><N><E><W><E><V><V><V><Q><V><E><D><D><G><D><G><D><Y><M><S><E><P><E><A><V><L><T><R><R><K><S><N><V><I><R><K><P><C><A><A><E><P><A><L><S><A><G><S><L><A><A><E><P><A><E><N><R><K><G><T><A><V><P><V><E><C><P><T><C><H><K><K><F><L><S><K><Y><Y><L><K><V><H><N><R><K><H><T><G><E><K><P><F><E><C><P><K><C><G><K><C><Y><F><R><K><E><N><L><L><E><H><E><A><R><N><C><M><N><R><S><E><Q><V><F><T><C><S><V><C><Q><E><T><F><R><R><R><M><E><L><R><V><H><M><V><S><H><T><G><E><M><P><Y><K><C><S><S><C><S><Q><Q><F><M><Q><K><K><D><L><Q><S><H><M><I><K><L><H><G><A><P><K><P><H><A><C><P><T><C><A><K><C><F><L><S><R><T><E><L><Q><L><H><E><A><F><K><H><R><G><E><K><L><F><V><C><E><E><C><G><H><R><A><S><S><R><N><G><L><Q><M><H><I><K><A><K><H><R><N><E><R><P><H><V><C><E><F><C><S><H><A><F><T><Q><K><A><N><L><N><M><H><L><R><T><H><T><G><E><K><P><F><Q><C><H><L><C><G><K><T><F><R><T><Q><A><S><L><D><K><H><N><R><T><H><T><G><E><R><P><F><S><C><E><F><C><E><Q><R><F><T><E><K><G><P><L><L><R><H><V><A><S><R><H><Q><E><G><R><P><H><F><C><Q><I><C><G><K><T><F><K><A><V><E><Q><L><R><V><H><V><R><R><H><K><G><V><R><K><F><E><C><T><E><C><G><Y><K><F><T><R><Q><A><H><L><R><R><H><M><E><I><H><D><R><V><E><N><Y><N><P><R><Q><R><K><L><R><N><L><I><I><E><D><E><K><M><V><V><V><A><L><Q><P><P><A><E><L><E><V><G><S><A><E><V><I><V><E><S><L><A><Q><G><G><L><A><S><Q><L><P><G><Q><R><L><C><A><E><E><S><F><T><G><P><G><V><L><E><P><S><L><I><I><T><A><A><V><P><E><D><C><D><T>
Telomere-binding protein that acts as a regulator of telomere length . Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat . Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres . Also acts as a transcription regulator that binds to promoter regions . Regulates expression of a small subset of genes, including MTFP1 . Regulates expression the J and/or S elements in MHC II promoter . Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A .<BOP>
P10074
Q96EP1
CHFR_HUMAN
RING-type E3 ubiquitin transferase CHFR
Homo
<M><E><R><P><E><E><G><K><Q><S><P><P><P><Q><P><W><G><R><L><L><R><L><G><A><E><E><G><E><P><H><V><L><L><R><K><R><E><W><T><I><G><R><R><R><G><C><D><L><S><F><P><S><N><K><L><V><S><G><D><H><C><R><I><V><V><D><E><K><S><G><Q><V><T><L><E><D><T><S><T><S><G><T><V><I><N><K><L><K><V><V><K><K><Q><T><C><P><L><Q><T><G><D><V><I><Y><L><V><Y><R><K><N><E><P><E><H><N><V><A><Y><L><Y><E><S><L><S><E><K><Q><G><M><T><Q><E><S><F><E><A><N><K><E><N><V><F><H><G><T><K><D><T><S><G><A><G><A><G><R><G><A><D><P><R><V><P><P><S><S><P><A><T><Q><V><C><F><E><E><P><Q><P><S><T><S><T><S><D><L><F><P><T><A><S><A><S><S><T><E><P><S><P><A><G><R><E><R><S><S><S><C><G><S><G><G><G><G><I><S><P><K><G><S><G><P><S><V><A><S><D><E><V><S><S><F><A><S><A><L><P><D><R><K><T><A><S><F><S><S><L><E><P><Q><D><Q><E><D><L><E><P><V><K><K><K><M><R><G><D><G><D><L><D><L><N><G><Q><L><L><V><A><Q><P><R><R><N><A><Q><T><V><H><E><D><V><R><A><A><A><G><K><P><D><K><M><E><E><T><L><T><C><I><I><C><Q><D><L><L><H><D><C><V><S><L><Q><P><C><M><H><T><F><C><A><A><C><Y><S><G><W><M><E><R><S><S><L><C><P><T><C><R><C><P><V><E><R><I><C><K><N><H><I><L><N><N><L><V><E><A><Y><L><I><Q><H><P><D><K><S><R><S><E><E><D><V><Q><S><M><D><A><R><N><K><I><T><Q><D><M><L><Q><P><K><V><R><R><S><F><S><D><E><E><G><S><S><E><D><L><L><E><L><S><D><V><D><S><E><S><S><D><I><S><Q><P><Y><V><V><C><R><Q><C><P><E><Y><R><R><Q><A><A><Q><P><P><H><C><P><A><P><E><G><E><P><G><A><P><Q><A><L><G><D><A><P><S><T><S><V><S><L><T><T><A><V><Q><D><Y><V><C><P><L><Q><G><S><H><A><L><C><T><C><C><F><Q><P><M><P><D><R><R><A><E><R><E><Q><D><P><R><V><A><P><Q><Q><C><A><V><C><L><Q><P><F><C><H><L><Y><W><G><C><T><R><T><G><C><Y><G><C><L><A><P><F><C><E><L><N><L><G><D><K><C><L><D><G><V><L><N><N><N><S><Y><E><S><D><I><L><K><N><Y><L><A><T><R><G><L><T><W><K><N><M><L><T><E><S><L><V><A><L><Q><R><G><V><F><L><L><S><D><Y><R><V><T><G><D><T><V><L><C><Y><C><C><G><L><R><S><F><R><E><L><T><Y><Q><Y><R><Q><N><I><P><A><S><E><L><P><V><A><V><T><S><R><P><D><C><Y><W><G><R><N><C><R><T><Q><V><K><A><H><H><A><M><K><F><N><H><I><C><E><Q><T><R><F><K><N>
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.<BOP>
Q96EP1
Q8NFR3
SPTSB_HUMAN
Small subunit of serine palmitoyltransferase B
Homo
<M><D><L><R><R><V><K><E><Y><F><S><W><L><Y><Y><Q><Y><Q><I><I><S><C><C><A><V><L><E><P><W><E><R><S><M><F><N><T><I><L><L><T><I><I><A><M><V><V><Y><T><A><Y><V><F><I><P><I><H><I><R><L><A><W><E><F><F><S><K><I><C><G><Y><H><S><T><I><S><N>
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction.<BOP>
Q8NFR3
Q8WXK4
ASB12_HUMAN
Ankyrin repeat and SOCS box protein 12
Homo
<M><N><L><M><D><I><T><K><I><F><S><L><L><Q><P><D><K><E><E><E><D><T><D><T><E><E><K><Q><A><L><N><Q><A><V><Y><D><N><D><S><Y><T><L><D><Q><L><L><R><Q><E><R><Y><K><R><F><I><N><S><R><S><G><W><G><V><P><G><T><P><L><R><L><A><A><S><Y><G><H><L><S><C><L><Q><V><L><L><A><H><G><A><D><V><D><S><L><D><V><K><A><Q><T><P><L><F><T><A><V><S><H><G><H><L><D><C><V><R><V><L><L><E><A><G><A><S><P><G><G><S><I><Y><N><N><C><S><P><V><L><T><A><A><R><D><G><A><V><A><I><L><Q><E><L><L><D><H><G><A><E><A><N><V><K><A><K><L><P><V><W><A><S><N><I><A><S><C><S><G><P><L><Y><L><A><A><V><Y><G><H><L><D><C><F><R><L><L><L><L><H><G><A><D><P><D><Y><N><C><T><D><Q><G><L><L><A><R><V><P><R><P><R><T><L><L><E><I><C><L><H><H><N><C><E><P><E><Y><I><Q><L><L><I><D><F><G><A><N><I><Y><L><P><S><L><S><L><D><L><T><S><Q><D><D><K><G><I><A><L><L><L><Q><A><R><A><T><P><R><S><L><L><S><Q><V><R><L><V><V><R><R><A><L><C><Q><A><G><Q><P><Q><A><I><N><Q><L><D><I><P><P><M><L><I><S><Y><L><K><H><Q><L>
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<BOP>
Q8WXK4
P43116
PE2R2_HUMAN
Prostanoid EP2 receptor
Homo
<M><G><N><A><S><N><D><S><Q><S><E><D><C><E><T><R><Q><W><L><P><P><G><E><S><P><A><I><S><S><V><M><F><S><A><G><V><L><G><N><L><I><A><L><A><L><L><A><R><R><W><R><G><D><V><G><C><S><A><G><R><R><S><S><L><S><L><F><H><V><L><V><T><E><L><V><F><T><D><L><L><G><T><C><L><I><S><P><V><V><L><A><S><Y><A><R><N><Q><T><L><V><A><L><A><P><E><S><R><A><C><T><Y><F><A><F><A><M><T><F><F><S><L><A><T><M><L><M><L><F><A><M><A><L><E><R><Y><L><S><I><G><H><P><Y><F><Y><Q><R><R><V><S><R><S><G><G><L><A><V><L><P><V><I><Y><A><V><S><L><L><F><C><S><L><P><L><L><D><Y><G><Q><Y><V><Q><Y><C><P><G><T><W><C><F><I><R><H><G><R><T><A><Y><L><Q><L><Y><A><T><L><L><L><L><L><I><V><S><V><L><A><C><N><F><S><V><I><L><N><L><I><R><M><H><R><R><S><R><R><S><R><C><G><P><S><L><G><S><G><R><G><G><P><G><A><R><R><R><G><E><R><V><S><M><A><E><E><T><D><H><L><I><L><L><A><I><M><T><I><T><F><A><V><C><S><L><P><F><T><I><F><A><Y><M><N><E><T><S><S><R><K><E><K><W><D><L><Q><A><L><R><F><L><S><I><N><S><I><I><D><P><W><V><F><A><I><L><R><P><P><V><L><R><L><M><R><S><V><L><C><C><R><I><S><L><R><T><Q><D><A><T><Q><T><S><C><S><T><Q><S><D><A><S><K><Q><A><D><L>
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.<BOP>
P43116
O60861
GAS7_HUMAN
Growth arrest-specific protein 7
Homo
<M><S><G><A><R><C><R><T><L><Y><P><F><S><G><E><R><H><G><Q><G><L><R><F><A><A><G><E><L><I><T><L><L><Q><V><P><D><G><G><W><W><E><G><E><K><E><D><G><L><R><G><W><F><P><A><S><Y><V><Q><L><L><E><K><P><G><M><V><P><P><P><P><G><E><E><S><Q><T><V><I><L><P><P><G><W><Q><S><Y><L><S><P><Q><G><R><R><Y><Y><V><N><T><T><T><N><E><T><T><W><E><R><P><S><S><S><P><G><I><P><A><S><P><G><S><H><R><S><S><L><P><P><T><V><N><G><Y><H><A><S><G><T><P><A><H><P><P><E><T><A><H><M><S><V><R><K><S><T><G><D><S><Q><N><L><G><S><S><S><P><S><K><K><Q><S><K><E><N><T><I><T><I><N><C><V><T><F><P><H><P><D><T><M><P><E><Q><Q><L><L><K><P><T><E><W><S><Y><C><D><Y><F><W><A><D><K><K><D><P><Q><G><N><G><T><V><A><G><F><E><L><L><L><Q><K><Q><L><K><G><K><Q><M><Q><K><E><M><S><E><F><I><R><E><R><I><K><I><E><E><D><Y><A><K><N><L><A><K><L><S><Q><N><S><L><A><S><Q><E><E><G><S><L><G><E><A><W><A><Q><V><K><K><S><L><A><D><E><A><E><V><H><L><K><F><S><A><K><L><H><S><E><V><E><K><P><L><M><N><F><R><E><N><F><K><K><D><M><K><K><C><D><H><H><I><A><D><L><R><K><Q><L><A><S><R><Y><A><S><V><E><K><A><R><K><A><L><T><E><R><Q><R><D><L><E><M><K><T><Q><Q><L><E><I><K><L><S><N><K><T><E><E><D><I><K><K><A><R><R><K><S><T><Q><A><G><D><D><L><M><R><C><V><D><L><Y><N><Q><A><Q><S><K><W><F><E><E><M><V><T><T><T><L><E><L><E><R><L><E><V><E><R><V><E><M><I><R><Q><H><L><C><Q><Y><T><Q><L><R><H><E><T><D><M><F><N><Q><S><T><V><E><P><V><D><Q><L><L><R><K><V><D><P><A><K><D><R><E><L><W><V><R><E><H><K><T><G><N><I><R><P><V><D><M><E><I>
May play a role in promoting maturation and morphological differentiation of cerebellar neurons.<BOP>
O60861
Q8IVM8
S22A9_HUMAN
Solute carrier family 22 member 9
Homo
<M><A><F><Q><D><L><L><G><H><A><G><D><L><W><R><F><Q><I><L><Q><T><V><F><L><S><I><F><A><V><A><T><Y><L><H><F><M><L><E><N><F><T><A><F><I><P><G><H><R><C><W><V><H><I><L><D><N><D><T><V><S><D><N><D><T><G><A><L><S><Q><D><A><L><L><R><I><S><I><P><L><D><S><N><M><R><P><E><K><C><R><R><F><V><H><P><Q><W><Q><L><L><H><L><N><G><T><F><P><N><T><S><D><A><D><M><E><P><C><V><D><G><W><V><Y><D><R><I><S><F><S><S><T><I><V><T><E><W><D><L><V><C><D><S><Q><S><L><T><S><V><A><K><F><V><F><M><A><G><M><M><V><G><G><I><L><G><G><H><L><S><D><R><F><G><R><R><F><V><L><R><W><C><Y><L><Q><V><A><I><V><G><T><C><A><A><L><A><P><T><F><L><I><Y><C><S><L><R><F><L><S><G><I><A><A><M><S><L><I><T><N><T><I><M><L><I><A><E><W><A><T><H><R><F><Q><A><M><G><I><T><L><G><M><C><P><S><G><I><A><F><M><T><L><A><G><L><A><F><A><I><R><D><W><H><I><L><Q><L><V><V><S><V><P><Y><F><V><I><F><L><T><S><S><W><L><L><E><S><A><R><W><L><I><I><N><N><K><P><E><E><G><L><K><E><L><R><K><A><A><H><R><S><G><M><K><N><A><R><D><T><L><T><L><E><I><L><K><S><T><M><K><K><E><L><E><A><A><Q><K><K><K><P><S><L><C><E><M><L><H><M><P><N><I><C><K><R><I><S><L><L><S><F><T><R><F><A><N><F><M><A><Y><F><G><L><N><L><H><V><Q><H><L><G><N><N><V><F><L><L><Q><T><L><F><G><A><V><I><L><L><A><N><C><V><A><P><W><A><L><K><Y><M><N><R><R><A><S><Q><M><L><L><M><F><L><L><A><I><C><L><L><A><I><I><F><V><P><Q><E><M><Q><T><L><R><E><V><L><A><T><L><G><L><G><A><S><A><L><A><N><T><L><A><F><A><H><G><N><E><V><I><P><T><I><I><R><A><R><A><M><G><I><N><A><T><F><A><N><I><A><G><A><L><A><P><L><M><M><I><L><S><V><Y><S><P><P><L><P><W><I><I><Y><G><V><F><P><F><I><S><G><F><A><F><L><L><L><P><E><T><R><N><K><P><L><F><D><T><I><Q><D><E><K><N><E><R><K><D><P><R><E><P><K><Q><E><D><P><R><V><E><V><T><Q><F>
Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) . Can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised . It is specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate (propanoate), butyrate (butanoate) and valerate (pentanoate) . May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs, in particular butanoate, at the sinusoidal membrane of hepatocytes .<BOP>
Q8IVM8
O14874
BCKD_HUMAN
Branched-chain alpha-ketoacid dehydrogenase kinase
Homo
<M><I><L><A><S><V><L><R><S><G><P><G><G><G><L><P><L><R><P><L><L><G><P><A><L><A><L><R><A><R><S><T><S><A><T><D><T><H><H><V><E><M><A><R><E><R><S><K><T><V><T><S><F><Y><N><Q><S><A><I><D><A><A><A><E><K><P><S><V><R><L><T><P><T><M><M><L><Y><A><G><R><S><Q><D><G><S><H><L><L><K><S><A><R><Y><L><Q><Q><E><L><P><V><R><I><A><H><R><I><K><G><F><R><C><L><P><F><I><I><G><C><N><P><T><I><L><H><V><H><E><L><Y><I><R><A><F><Q><K><L><T><D><F><P><P><I><K><D><Q><A><D><E><A><Q><Y><C><Q><L><V><R><Q><L><L><D><D><H><K><D><V><V><T><L><L><A><E><G><L><R><E><S><R><K><H><I><E><D><E><K><L><V><R><Y><F><L><D><K><T><L><T><S><R><L><G><I><R><M><L><A><T><H><H><L><A><L><H><E><D><K><P><D><F><V><G><I><I><C><T><R><L><S><P><K><K><I><I><E><K><W><V><D><F><A><R><R><L><C><E><H><K><Y><G><N><A><P><R><V><R><I><N><G><H><V><A><A><R><F><P><F><I><P><M><P><L><D><Y><I><L><P><E><L><L><K><N><A><M><R><A><T><M><E><S><H><L><D><T><P><Y><N><V><P><D><V><V><I><T><I><A><N><N><D><V><D><L><I><I><R><I><S><D><R><G><G><G><I><A><H><K><D><L><D><R><V><M><D><Y><H><F><T><T><A><E><A><S><T><Q><D><P><R><I><S><P><L><F><G><H><L><D><M><H><S><G><A><Q><S><G><P><M><H><G><F><G><F><G><L><P><T><S><R><A><Y><A><E><Y><L><G><G><S><L><Q><L><Q><S><L><Q><G><I><G><T><D><V><Y><L><R><L><R><H><I><D><G><R><E><E><S><F><R><I>
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.<BOP>
O14874
Q6PI26
SHQ1_HUMAN
Protein SHQ1 homolog
Homo
<M><L><T><P><A><F><D><L><S><Q><D><P><D><F><L><T><I><A><I><R><V><P><Y><A><R><V><S><E><F><D><V><Y><F><E><G><S><D><F><K><F><Y><A><K><P><Y><F><L><R><L><T><L><P><G><R><I><V><E><N><G><S><E><Q><G><S><Y><D><A><D><K><G><I><F><T><I><R><L><P><K><E><T><P><G><Q><H><F><E><G><L><N><M><L><T><A><L><L><A><P><R><K><S><R><T><A><K><P><L><V><E><E><I><G><A><S><E><I><P><E><E><V><V><D><D><E><E><F><D><W><E><I><E><Q><T><P><C><E><E><V><S><E><S><A><L><N><P><Q><C><H><Y><G><F><G><N><L><R><S><G><V><L><Q><R><L><Q><D><E><L><S><D><V><I><D><I><K><D><P><D><F><T><P><A><A><E><R><R><Q><K><R><L><A><A><E><L><A><K><F><D><P><D><H><Y><L><A><D><F><F><E><D><E><A><I><E><Q><I><L><K><Y><N><P><W><W><T><D><K><Y><S><K><M><M><A><F><L><E><K><S><Q><E><Q><E><N><H><A><T><L><V><S><F><S><E><E><E><K><Y><Q><L><R><K><F><V><N><K><S><Y><L><L><D><K><R><A><C><R><Q><V><C><Y><S><L><I><D><I><L><L><A><Y><C><Y><E><T><R><V><T><E><G><E><K><N><V><E><S><A><W><N><I><R><K><L><S><P><T><L><C><W><F><E><T><W><T><N><V><H><D><I><M><V><S><F><G><R><R><V><L><C><Y><P><L><Y><R><H><F><K><L><V><M><K><A><Y><R><D><T><I><K><I><L><Q><L><G><K><S><A><V><L><K><C><L><L><D><I><H><K><I><F><Q><E><N><D><P><A><Y><I><L><N><D><L><Y><I><S><D><Y><C><V><W><I><Q><K><V><K><S><K><K><L><A><A><L><A><E><A><L><K><E><V><S><L><T><K><A><Q><L><G><L><E><L><E><E><L><E><A><A><A><L><L><V><Q><E><E><E><T><A><L><K><A><A><H><S><V><S><G><Q><Q><T><L><C><S><S><S><E><A><S><D><S><E><D><S><D><S><S><V><S><S><G><N><E><D><S><G><S><D><S><E><Q><D><E><L><K><D><S><P><S><E><T><V><S><S><L><Q><G><P><F><L><E><E><S><S><A><F><L><I><V><D><G><G><V><R><R><N><T><A><I><Q><E><S><D><A><S><Q><G><K><P><L><A><S><S><W><P><L><G><V><S><G><P><L><I><E><E><L><G><E><Q><L><K><T><T><V><Q><V><S><E><P><K><G><T><T><A><V><N><R><S><N><I><Q><E><R><D><G><C><Q><T><P><N><N>
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.<BOP>
Q6PI26
Q9UK59
DBR1_HUMAN
Lariat debranching enzyme
Homo
<M><R><V><A><V><A><G><C><C><H><G><E><L><D><K><I><Y><E><T><L><A><L><A><E><R><R><G><P><G><P><V><D><L><L><L><C><C><G><D><F><Q><A><V><R><N><E><A><D><L><R><C><M><A><V><P><P><K><Y><R><H><M><Q><T><F><Y><R><Y><Y><S><G><E><K><K><A><P><V><L><T><L><F><I><G><G><N><H><E><A><S><N><H><L><Q><E><L><P><Y><G><G><W><V><A><P><N><I><Y><Y><L><G><L><A><G><V><V><K><Y><R><G><V><R><I><G><G><I><S><G><I><F><K><S><H><D><Y><R><K><G><H><F><E><C><P><P><Y><N><S><S><T><I><R><S><I><Y><H><V><R><N><I><E><V><Y><K><L><K><Q><L><K><Q><P><I><D><I><F><L><S><H><D><W><P><R><S><I><Y><H><Y><G><N><K><K><Q><L><L><K><T><K><S><F><F><R><Q><E><V><E><N><N><T><L><G><S><P><A><A><S><E><L><L><E><H><L><K><P><T><Y><W><F><S><A><H><L><H><V><K><F><A><A><L><M><Q><H><Q><A><K><D><K><G><Q><T><A><R><A><T><K><F><L><A><L><D><K><C><L><P><H><R><D><F><L><Q><I><L><E><I><E><H><D><P><S><A><P><D><Y><L><E><Y><D><I><E><W><L><T><I><L><R><A><T><D><D><L><I><N><V><T><G><R><L><W><N><M><P><E><N><N><G><L><H><A><R><W><D><Y><S><A><T><E><E><G><M><K><E><V><L><E><K><L><N><H><D><L><K><V><P><C><N><F><S><V><T><A><A><C><Y><D><P><S><K><P><Q><T><Q><M><Q><L><I><H><R><I><N><P><Q><T><T><E><F><C><A><Q><L><G><I><I><D><I><N><V><R><L><Q><K><S><K><E><E><H><H><V><C><G><E><Y><E><E><Q><D><D><V><E><S><N><D><S><G><E><D><Q><S><E><Y><N><T><D><T><S><A><L><S><S><I><N><P><D><E><I><M><L><D><E><E><E><D><E><D><S><I><V><S><A><H><S><G><M><N><T><P><S><V><E><P><S><D><Q><A><S><E><F><S><A><S><F><S><D><V><R><I><L><P><G><S><M><I><V><S><S><D><D><T><V><D><S><T><I><D><R><E><G><K><P><G><G><T><V><E><S><G><N><G><E><D><L><T><K><V><P><L><K><R><L><S><D><E><H><E><P><E><Q><R><K><K><I><K><R><R><N><Q><A><I><Y><A><A><V><D><D><D><D><D><D><A><A>
Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover . Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem .<BOP>
Q9UK59
Q8NDX6
ZN740_HUMAN
OriLyt TD-element-binding protein 7
Homo
<M><A><Q><A><S><L><L><A><C><E><G><L><A><G><V><S><L><V><P><T><A><A><S><K><K><M><M><L><S><Q><I><A><S><K><Q><A><E><N><G><E><R><A><G><S><P><D><V><L><R><C><S><S><Q><G><H><R><K><D><S><D><K><S><R><S><R><K><D><D><D><S><L><S><E><A><S><H><S><K><K><T><V><K><K><V><V><V><V><E><Q><N><G><S><F><Q><V><K><I><P><K><N><F><V><C><E><H><C><F><G><A><F><R><S><S><Y><H><L><K><R><H><I><L><I><H><T><G><E><K><P><F><E><C><D><I><C><D><M><R><F><I><Q><K><Y><H><L><E><R><H><K><R><V><H><S><G><E><K><P><Y><Q><C><E><R><C><H><Q><C><F><S><R><T><D><R><L><L><R><H><K><R><M><C><Q><G><C><Q><S><K><T><S><D><G><Q><F><S><L>
May be involved in transcriptional regulation.<BOP>
Q8NDX6
Q9BZZ5
API5_HUMAN
Protein XAGL
Homo
<M><P><T><V><E><E><L><Y><R><N><Y><G><I><L><A><D><A><T><E><Q><V><G><Q><H><K><D><A><Y><Q><V><I><L><D><G><V><K><G><G><T><K><E><K><R><L><A><A><Q><F><I><P><K><F><F><K><H><F><P><E><L><A><D><S><A><I><N><A><Q><L><D><L><C><E><D><E><D><V><S><I><R><R><Q><A><I><K><E><L><P><Q><F><A><T><G><E><N><L><P><R><V><A><D><I><L><T><Q><L><L><Q><T><D><D><S><A><E><F><N><L><V><N><N><A><L><L><S><I><F><K><M><D><A><K><G><T><L><G><G><L><F><S><Q><I><L><Q><G><E><D><I><V><R><E><R><A><I><K><F><L><S><T><K><L><K><T><L><P><D><E><V><L><T><K><E><V><E><E><L><I><L><T><E><S><K><K><V><L><E><D><V><T><G><E><E><F><V><L><F><M><K><I><L><S><G><L><K><S><L><Q><T><V><S><G><R><Q><Q><L><V><E><L><V><A><E><Q><A><D><L><E><Q><T><F><N><P><S><D><P><D><C><V><D><R><L><L><Q><C><T><R><Q><A><V><P><L><F><S><K><N><V><H><S><T><R><F><V><T><Y><F><C><E><Q><V><L><P><N><L><G><T><L><T><T><P><V><E><G><L><D><I><Q><L><E><V><L><K><L><L><A><E><M><S><S><F><C><G><D><M><E><K><L><E><T><N><L><R><K><L><F><D><K><L><L><E><Y><M><P><L><P><P><E><E><A><E><N><G><E><N><A><G><N><E><E><P><K><L><Q><F><S><Y><V><E><C><L><L><Y><S><F><H><Q><L><G><R><K><L><P><D><F><L><T><A><K><L><N><A><E><K><L><K><D><F><K><I><R><L><Q><Y><F><A><R><G><L><Q><V><Y><I><R><Q><L><R><L><A><L><Q><G><K><T><G><E><A><L><K><T><E><E><N><K><I><K><V><V><A><L><K><I><T><N><N><I><N><V><L><I><K><D><L><F><H><I><P><P><S><Y><K><S><T><V><T><L><S><W><K><P><V><Q><K><V><E><I><G><Q><K><R><A><S><E><D><T><T><S><G><S><P><P><K><K><S><S><A><G><P><K><R><D><A><R><Q><I><Y><N><P><P><S><G><K><Y><S><S><N><L><G><N><F><N><Y><E><Q><R><G><A><F><R><G><S><R><G><G><R><G><W><G><T><R><G><N><R><S><R><G><R><L><Y>
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<BOP>
Q9BZZ5
O00712
NFIB_HUMAN
TGGCA-binding protein
Homo
<M><M><Y><S><P><I><C><L><T><Q><D><E><F><H><P><F><I><E><A><L><L><P><H><V><R><A><I><A><Y><T><W><F><N><L><Q><A><R><K><R><K><Y><F><K><K><H><E><K><R><M><S><K><D><E><E><R><A><V><K><D><E><L><L><S><E><K><P><E><I><K><Q><K><W><A><S><R><L><L><A><K><L><R><K><D><I><R><Q><E><Y><R><E><D><F><V><L><T><V><T><G><K><K><H><P><C><C><V><L><S><N><P><D><Q><K><G><K><I><R><R><I><D><C><L><R><Q><A><D><K><V><W><R><L><D><L><V><M><V><I><L><F><K><G><I><P><L><E><S><T><D><G><E><R><L><M><K><S><P><H><C><T><N><P><A><L><C><V><Q><P><H><H><I><T><V><S><V><K><E><L><D><L><F><L><A><Y><Y><V><Q><E><Q><D><S><G><Q><S><G><S><P><S><H><N><D><P><A><K><N><P><P><G><Y><L><E><D><S><F><V><K><S><G><V><F><N><V><S><E><L><V><R><V><S><R><T><P><I><T><Q><G><T><G><V><N><F><P><I><G><E><I><P><S><Q><P><Y><Y><H><D><M><N><S><G><V><N><L><Q><R><S><L><S><S><P><P><S><S><K><R><P><K><T><I><S><I><D><E><N><M><E><P><S><P><T><G><D><F><Y><P><S><P><S><S><P><A><A><G><S><R><T><W><H><E><R><D><Q><D><M><S><S><P><T><T><M><K><K><P><E><K><P><L><F><S><S><A><S><P><Q><D><S><S><P><R><L><S><T><F><P><Q><H><H><H><P><G><I><P><G><V><A><H><S><V><I><S><T><R><T><P><P><P><P><S><P><L><P><F><P><T><Q><A><I><L><P><P><A><P><S><S><Y><F><S><H><P><T><I><R><Y><P><P><H><L><N><P><Q><D><T><L><K><N><Y><V><P><S><Y><D><P><S><S><P><Q><T><S><Q><S><W><Y><L><G>
Transcriptional activator of GFAP, essential for proper brain development . Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.<BOP>
O00712
Q9NUQ8
ABCF3_HUMAN
ATP-binding cassette sub-family F member 3
Homo
<M><A><T><C><A><E><I><L><R><S><E><F><P><E><I><D><G><Q><V><F><D><Y><V><T><G><V><L><H><S><G><S><A><D><F><E><S><V><D><D><L><V><E><A><V><G><E><L><L><Q><E><V><S><G><D><S><K><D><D><A><G><I><R><A><V><C><Q><R><M><Y><N><T><L><R><L><A><E><P><Q><S><Q><G><N><S><Q><V><L><L><D><A><P><I><Q><L><S><K><I><T><E><N><Y><D><C><G><T><K><L><P><G><L><L><K><R><E><Q><S><S><T><V><N><A><K><K><L><E><K><A><E><A><R><L><K><A><K><Q><E><K><R><S><E><K><D><T><L><K><T><S><N><P><L><V><L><E><E><A><S><A><S><Q><A><G><S><R><K><E><S><R><L><E><S><S><G><K><N><K><S><Y><D><V><R><I><E><N><F><D><V><S><F><G><D><R><V><L><L><A><G><A><D><V><N><L><A><W><G><R><R><Y><G><L><V><G><R><N><G><L><G><K><T><T><L><L><K><M><L><A><T><R><S><L><R><V><P><A><H><I><S><L><L><H><V><E><Q><E><V><A><G><D><D><T><P><A><L><Q><S><V><L><E><S><D><S><V><R><E><D><L><L><R><R><E><R><E><L><T><A><Q><I><A><A><G><R><A><E><G><S><E><A><A><E><L><A><E><I><Y><A><K><L><E><E><I><E><A><D><K><A><P><A><R><A><S><V><I><L><A><G><L><G><F><T><P><K><M><Q><Q><Q><P><T><R><E><F><S><G><G><W><R><M><R><L><A><L><A><R><A><L><F><A><R><P><D><L><L><L><L><D><E><P><T><N><M><L><D><V><R><A><I><L><W><L><E><N><Y><L><Q><T><W><P><S><T><I><L><V><V><S><H><D><R><N><F><L><N><A><I><A><T><D><I><I><H><L><H><S><Q><R><L><D><G><Y><R><G><D><F><E><T><F><I><K><S><K><Q><E><R><L><L><N><Q><Q><R><E><Y><E><A><Q><Q><Q><Y><R><Q><H><I><Q><V><F><I><D><R><F><R><Y><N><A><N><R><A><S><Q><V><Q><S><K><L><K><M><L><E><K><L><P><E><L><K><P><V><D><K><E><S><E><V><V><M><K><F><P><D><G><F><E><K><F><S><P><P><I><L><Q><L><D><E><V><D><F><Y><Y><D><P><K><H><V><I><F><S><R><L><S><V><S><A><D><L><E><S><R><I><C><V><V><G><E><N><G><A><G><K><S><T><M><L><K><L><L><L><G><D><L><A><P><V><R><G><I><R><H><A><H><R><N><L><K><I><G><Y><F><S><Q><H><H><V><E><Q><L><D><L><N><V><S><A><V><E><L><L><A><R><K><F><P><G><R><P><E><E><E><Y><R><H><Q><L><G><R><Y><G><I><S><G><E><L><A><M><R><P><L><A><S><L><S><G><G><Q><K><S><R><V><A><F><A><Q><M><T><M><P><C><P><N><F><Y><I><L><D><E><P><T><N><H><L><D><M><E><T><I><E><A><L><G><R><A><L><N><N><F><R><G><G><V><I><L><V><S><H><D><E><R><F><I><R><L><V><C><R><E><L><W><V><C><E><G><G><G><V><T><R><V><E><G><G><F><D><Q><Y><R><A><L><L><Q><E><Q><F><R><R><E><G><F><L>
Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.<BOP>
Q9NUQ8
Q695T7
S6A19_HUMAN
System B(0) neutral amino acid transporter AT1
Homo
<M><V><R><L><V><L><P><N><P><G><L><D><A><R><I><P><S><L><A><E><L><E><T><I><E><Q><E><E><A><S><S><R><P><K><W><D><N><K><A><Q><Y><M><L><T><C><L><G><F><C><V><G><L><G><N><V><W><R><F><P><Y><L><C><Q><S><H><G><G><G><A><F><M><I><P><F><L><I><L><L><V><L><E><G><I><P><L><L><Y><L><E><F><A><I><G><Q><R><L><R><R><G><S><L><G><V><W><S><S><I><H><P><A><L><K><G><L><G><L><A><S><M><L><T><S><F><M><V><G><L><Y><Y><N><T><I><I><S><W><I><M><W><Y><L><F><N><S><F><Q><E><P><L><P><W><S><D><C><P><L><N><E><N><Q><T><G><Y><V><D><E><C><A><R><S><S><P><V><D><Y><F><W><Y><R><E><T><L><N><I><S><T><S><I><S><D><S><G><S><I><Q><W><W><M><L><L><C><L><A><C><A><W><S><V><L><Y><M><C><T><I><R><G><I><E><T><T><G><K><A><V><Y><I><T><S><T><L><P><Y><V><V><L><T><I><F><L><I><R><G><L><T><L><K><G><A><T><N><G><I><V><F><L><F><T><P><N><V><T><E><L><A><Q><P><D><T><W><L><D><A><G><A><Q><V><F><F><S><F><S><L><A><F><G><G><L><I><S><F><S><S><Y><N><S><V><H><N><N><C><E><K><D><S><V><I><V><S><I><I><N><G><F><T><S><V><Y><V><A><I><V><V><Y><S><V><I><G><F><R><A><T><Q><R><Y><D><D><C><F><S><T><N><I><L><T><L><I><N><G><F><D><L><P><E><G><N><V><T><Q><E><N><F><V><D><M><Q><Q><R><C><N><A><S><D><P><A><A><Y><A><Q><L><V><F><Q><T><C><D><I><N><A><F><L><S><E><A><V><E><G><T><G><L><A><F><I><V><F><T><E><A><I><T><K><M><P><L><S><P><L><W><S><V><L><F><F><I><M><L><F><C><L><G><L><S><S><M><F><G><N><M><E><G><V><V><V><P><L><Q><D><L><R><V><I><P><P><K><W><P><K><E><V><L><T><G><L><I><C><L><G><T><F><L><I><G><F><I><F><T><L><N><S><G><Q><Y><W><L><S><L><L><D><S><Y><A><G><S><I><P><L><L><I><I><A><F><C><E><M><F><S><V><V><Y><V><Y><G><V><D><R><F><N><K><D><I><E><F><M><I><G><H><K><P><N><I><F><W><Q><V><T><W><R><V><V><S><P><L><L><M><L><I><I><F><L><F><F><F><V><V><E><V><S><Q><E><L><T><Y><S><I><W><D><P><G><Y><E><E><F><P><K><S><Q><K><I><S><Y><P><N><W><V><Y><V><V><V><V><I><V><A><G><V><P><S><L><T><I><P><G><Y><A><I><Y><K><L><I><R><N><H><C><Q><K><P><G><D><H><Q><G><L><V><S><T><L><S><T><A><S><M><N><G><D><L><K><Y>
Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells . This uptake is sodium-dependent and chloride-independent . Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity .<BOP>
Q695T7
Q9BTC8
MTA3_HUMAN
Metastasis-associated protein MTA3
Homo
<M><A><A><N><M><Y><R><V><G><D><Y><V><Y><F><E><N><S><S><S><N><P><Y><L><I><R><R><I><E><E><L><N><K><T><A><S><G><N><V><E><A><K><V><V><C><F><Y><R><R><R><D><I><S><N><T><L><I><M><L><A><D><K><H><A><K><E><I><E><E><E><S><E><T><T><V><E><A><D><L><T><D><K><Q><K><H><Q><L><K><H><R><E><L><F><L><S><R><Q><Y><E><S><L><P><A><T><H><I><R><G><K><C><S><V><A><L><L><N><E><T><E><S><V><L><S><Y><L><D><K><E><D><T><F><F><Y><S><L><V><Y><D><P><S><L><K><T><L><L><A><D><K><G><E><I><R><V><G><P><R><Y><Q><A><D><I><P><E><M><L><L><E><G><E><S><D><E><R><E><Q><S><K><L><E><V><K><V><W><D><P><N><S><P><L><T><D><R><Q><I><D><Q><F><L><V><V><A><R><A><V><G><T><F><A><R><A><L><D><C><S><S><S><V><R><Q><P><S><L><H><M><S><A><A><A><A><S><R><D><I><T><L><F><H><A><M><D><T><L><Y><R><H><S><Y><D><L><S><S><A><I><S><V><L><V><P><L><G><G><P><V><L><C><R><D><E><M><E><E><W><S><A><S><E><A><S><L><F><E><E><A><L><E><K><Y><G><K><D><F><N><D><I><R><Q><D><F><L><P><W><K><S><L><T><S><I><I><E><Y><Y><Y><M><W><K><T><T><D><R><Y><V><Q><Q><K><R><L><K><A><A><E><A><E><S><K><L><K><Q><V><Y><I><P><T><Y><S><K><P><N><P><N><Q><I><S><T><S><N><G><K><P><G><A><V><N><G><A><V><G><T><T><F><Q><P><Q><N><P><L><L><G><R><A><C><E><S><C><Y><A><T><Q><S><H><Q><W><Y><S><W><G><P><P><N><M><Q><C><R><L><C><A><I><C><W><L><Y><W><K><K><Y><G><G><L><K><M><P><T><Q><S><E><E><E><K><L><S><P><S><P><T><T><E><D><P><R><V><R><S><H><V><S><R><Q><A><M><Q><G><M><P><V><R><N><T><G><S><P><K><S><A><V><K><T><R><Q><A><F><F><L><H><T><T><Y><F><T><K><F><A><R><Q><V><C><K><N><T><L><R><L><R><Q><A><A><R><R><P><F><V><A><I><N><Y><A><A><I><R><A><E><Y><A><D><R><H><A><E><L><S><G><S><P><L><K><S><K><S><T><R><K><P><L><A><C><I><I><G><Y><L><E><I><H><P><A><K><K><P><N><V><I><R><S><T><P><S><L><Q><T><P><T><T><K><R><M><L><T><T><P><N><H><T><S><L><S><I><L><G><K><R><N><Y><S><H><H><N><G><L><D><E><L><T><C><C><V><S><D>
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.<BOP>
Q9BTC8
Q9ULR5
PAI2B_HUMAN
Polyadenylate-binding protein-interacting protein 2B
Homo
<M><N><G><S><N><M><A><N><T><S><P><S><V><K><S><K><E><D><Q><G><L><S><G><H><D><E><K><E><N><P><F><A><E><Y><M><W><M><E><N><E><E><D><F><N><R><Q><V><E><E><E><L><Q><E><Q><D><F><L><D><R><C><F><Q><E><M><L><D><E><E><D><Q><D><W><F><I><P><S><R><D><L><P><Q><A><M><G><Q><L><Q><Q><Q><L><N><G><L><S><V><S><E><G><H><D><S><E><D><I><L><S><K><S><N><L><N><P><D><A><K><E><F><I><P><G><E><K><Y>
Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.<BOP>
Q9ULR5
Q5J8M3
EMC4_HUMAN
Transmembrane protein 85
Homo
<M><T><A><Q><G><G><L><V><A><N><R><G><R><R><F><K><W><A><I><E><L><S><G><P><G><G><G><S><R><G><R><S><D><R><G><S><G><Q><G><D><S><L><Y><P><V><G><Y><L><D><K><Q><V><P><D><T><S><V><Q><E><T><D><R><I><L><V><E><K><R><C><W><D><I><A><L><G><P><L><K><Q><I><P><M><N><L><F><I><M><Y><M><A><G><N><T><I><S><I><F><P><T><M><M><V><C><M><M><A><W><R><P><I><Q><A><L><M><A><I><S><A><T><F><K><M><L><E><S><S><S><Q><K><F><L><Q><G><L><V><Y><L><I><G><N><L><M><G><L><A><L><A><V><Y><K><C><Q><S><M><G><L><L><P><T><H><A><S><D><W><L><A><F><I><E><P><P><E><R><M><E><F><S><G><G><G><L><L><L>
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).<BOP>
Q5J8M3
Q9H8S5
CCNP_HUMAN
Cyclin N-terminal domain-containing protein 2
Homo
<M><L><V><R><G><R><D><Q><G><S><G><S><R><L><G><P><I><V><R><R><W><A><P><R><P><S><P><L><Q><S><L><A><A><S><L><D><A><E><P><S><S><A><A><V><P><D><G><F><P><A><G><P><T><V><S><P><R><R><L><A><R><P><P><G><L><E><E><A><L><S><A><L><G><L><Q><G><E><R><E><Y><A><G><D><I><F><A><E><V><M><V><C><R><V><L><P><L><R><A><L><P><R><A><V><T><P><E><M><R><A><L><V><V><D><W><L><V><Q><V><H><E><Y><L><G><L><A><G><D><T><L><Y><L><A><V><H><L><L><D><S><Y><L><S><A><G><R><V><R><L><H><R><L><Q><L><L><G><V><A><C><L><F><V><A><C><K><M><E><E><C><V><L><P><E><P><A><F><L><C><L><L><S><A><D><S><F><S><R><A><E><L><L><R><A><E><R><R><I><L><S><R><L><D><F><R><L><H><H><P><G><P><L><L><C><L><G><L><L><A><A><L><A><G><S><S><P><Q><V><M><L><L><A><T><Y><F><L><E><L><S><L><L><E><A><E><A><A><G><W><E><P><G><R><R><A><A><A><A><L><S><L><A><H><R><L><L><D><G><A><G><S><R><L><Q><P><E><L><Y><R><C><S><L><G><G><G><S><V><W><G><H><R><S><F><R><D><L><P><S><W><S><F><L><R><S><R><R><M><R><D><N><Y>
Seems to be involved in the regulation of proliferation and migration.<BOP>
Q9H8S5
P04049
RAF1_HUMAN
Raf-1
Homo
<M><E><H><I><Q><G><A><W><K><T><I><S><N><G><F><G><F><K><D><A><V><F><D><G><S><S><C><I><S><P><T><I><V><Q><Q><F><G><Y><Q><R><R><A><S><D><D><G><K><L><T><D><P><S><K><T><S><N><T><I><R><V><F><L><P><N><K><Q><R><T><V><V><N><V><R><N><G><M><S><L><H><D><C><L><M><K><A><L><K><V><R><G><L><Q><P><E><C><C><A><V><F><R><L><L><H><E><H><K><G><K><K><A><R><L><D><W><N><T><D><A><A><S><L><I><G><E><E><L><Q><V><D><F><L><D><H><V><P><L><T><T><H><N><F><A><R><K><T><F><L><K><L><A><F><C><D><I><C><Q><K><F><L><L><N><G><F><R><C><Q><T><C><G><Y><K><F><H><E><H><C><S><T><K><V><P><T><M><C><V><D><W><S><N><I><R><Q><L><L><L><F><P><N><S><T><I><G><D><S><G><V><P><A><L><P><S><L><T><M><R><R><M><R><E><S><V><S><R><M><P><V><S><S><Q><H><R><Y><S><T><P><H><A><F><T><F><N><T><S><S><P><S><S><E><G><S><L><S><Q><R><Q><R><S><T><S><T><P><N><V><H><M><V><S><T><T><L><P><V><D><S><R><M><I><E><D><A><I><R><S><H><S><E><S><A><S><P><S><A><L><S><S><S><P><N><N><L><S><P><T><G><W><S><Q><P><K><T><P><V><P><A><Q><R><E><R><A><P><V><S><G><T><Q><E><K><N><K><I><R><P><R><G><Q><R><D><S><S><Y><Y><W><E><I><E><A><S><E><V><M><L><S><T><R><I><G><S><G><S><F><G><T><V><Y><K><G><K><W><H><G><D><V><A><V><K><I><L><K><V><V><D><P><T><P><E><Q><F><Q><A><F><R><N><E><V><A><V><L><R><K><T><R><H><V><N><I><L><L><F><M><G><Y><M><T><K><D><N><L><A><I><V><T><Q><W><C><E><G><S><S><L><Y><K><H><L><H><V><Q><E><T><K><F><Q><M><F><Q><L><I><D><I><A><R><Q><T><A><Q><G><M><D><Y><L><H><A><K><N><I><I><H><R><D><M><K><S><N><N><I><F><L><H><E><G><L><T><V><K><I><G><D><F><G><L><A><T><V><K><S><R><W><S><G><S><Q><Q><V><E><Q><P><T><G><S><V><L><W><M><A><P><E><V><I><R><M><Q><D><N><N><P><F><S><F><Q><S><D><V><Y><S><Y><G><I><V><L><Y><E><L><M><T><G><E><L><P><Y><S><H><I><N><N><R><D><Q><I><I><F><M><V><G><R><G><Y><A><S><P><D><L><S><K><L><Y><K><N><C><P><K><A><M><K><R><L><V><A><D><C><V><K><K><V><K><E><E><R><P><L><F><P><Q><I><L><S><S><I><E><L><L><Q><H><S><L><P><K><I><N><R><S><A><S><E><P><S><L><H><R><A><A><H><T><E><D><I><N><A><C><T><L><T><T><S><P><R><L><P><V><F>
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in
P04049
Q9HBH9
MKNK2_HUMAN
MAP kinase signal-integrating kinase 2
Homo
<M><V><Q><K><K><P><A><E><L><Q><G><F><H><R><S><F><K><G><Q><N><P><F><E><L><A><F><S><L><D><Q><P><D><H><G><D><S><D><F><G><L><Q><C><S><A><R><P><D><M><P><A><S><Q><P><I><D><I><P><D><A><K><K><R><G><K><K><K><K><R><G><R><A><T><D><S><F><S><G><R><F><E><D><V><Y><Q><L><Q><E><D><V><L><G><E><G><A><H><A><R><V><Q><T><C><I><N><L><I><T><S><Q><E><Y><A><V><K><I><I><E><K><Q><P><G><H><I><R><S><R><V><F><R><E><V><E><M><L><Y><Q><C><Q><G><H><R><N><V><L><E><L><I><E><F><F><E><E><E><D><R><F><Y><L><V><F><E><K><M><R><G><G><S><I><L><S><H><I><H><K><R><R><H><F><N><E><L><E><A><S><V><V><V><Q><D><V><A><S><A><L><D><F><L><H><N><K><G><I><A><H><R><D><L><K><P><E><N><I><L><C><E><H><P><N><Q><V><S><P><V><K><I><C><D><F><D><L><G><S><G><I><K><L><N><G><D><C><S><P><I><S><T><P><E><L><L><T><P><C><G><S><A><E><Y><M><A><P><E><V><V><E><A><F><S><E><E><A><S><I><Y><D><K><R><C><D><L><W><S><L><G><V><I><L><Y><I><L><L><S><G><Y><P><P><F><V><G><R><C><G><S><D><C><G><W><D><R><G><E><A><C><P><A><C><Q><N><M><L><F><E><S><I><Q><E><G><K><Y><E><F><P><D><K><D><W><A><H><I><S><C><A><A><K><D><L><I><S><K><L><L><V><R><D><A><K><Q><R><L><S><A><A><Q><V><L><Q><H><P><W><V><Q><G><C><A><P><E><N><T><L><P><T><P><M><V><L><Q><R><N><S><C><A><K><D><L><T><S><F><A><A><E><A><I><A><M><N><R><Q><L><A><Q><H><D><E><D><L><A><E><E><E><A><A><G><Q><G><Q><P><V><L><V><R><A><T><S><R><C><L><Q><L><S><P><P><S><Q><S><K><L><A><Q><R><R><Q><R><A><S><L><S><S><A><P><V><V><L><V><G><D><H><A>
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.<BOP>
Q9HBH9
Q9NPL8
TIDC1_HUMAN
Translocase of inner mitochondrial membrane domain-containing protein 1
Homo
<M><E><V><P><P><P><A><P><R><S><F><L><C><R><A><L><C><L><F><P><R><V><F><A><A><E><A><V><T><A><D><S><E><V><L><E><E><R><Q><K><R><L><P><Y><V><P><E><P><Y><Y><P><E><S><G><W><D><R><L><R><E><L><F><G><K><D><E><Q><Q><R><I><S><K><D><L><A><N><I><C><K><T><A><A><T><A><G><I><I><G><W><V><Y><G><G><I><P><A><F><I><H><A><K><Q><Q><Y><I><E><Q><S><Q><A><E><I><Y><H><N><R><F><D><A><V><Q><S><A><H><R><A><A><T><R><G><F><I><R><Y><G><W><R><W><G><W><R><T><A><V><F><V><T><I><F><N><T><V><N><T><S><L><N><V><Y><R><N><K><D><A><L><S><H><F><V><I><A><G><A><V><T><G><S><L><F><R><I><N><V><G><L><R><G><L><V><A><G><G><I><I><G><A><L><L><G><T><P><V><G><G><L><L><M><A><F><Q><K><Y><S><G><E><T><V><Q><E><R><K><Q><K><D><R><K><A><L><H><E><L><K><L><E><E><W><K><G><R><L><Q><V><T><E><H><L><P><E><K><I><E><S><S><L><Q><E><D><E><P><E><N><D><A><K><K><I><E><A><L><L><N><L><P><R><N><P><S><V><I><D><K><Q><D><K><D>
Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I.<BOP>
Q9NPL8
O00626
CCL22_HUMAN
MDC(7-69)
Homo
<M><D><R><L><Q><T><A><L><L><V><V><L><V><L><L><A><V><A><L><Q><A><T><E><A><G><P><Y><G><A><N><M><E><D><S><V><C><C><R><D><Y><V><R><Y><R><L><P><L><R><V><V><K><H><F><Y><W><T><S><D><S><C><P><R><P><G><V><V><L><L><T><F><R><D><K><E><I><C><A><D><P><R><V><P><W><V><K><M><I><L><N><K><L><S><Q>
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.<BOP>
O00626
Q96FX2
DPH3_HUMAN
DelGEF-interacting protein 1
Homo
<M><A><V><F><H><D><E><V><E><I><E><D><F><Q><Y><D><E><D><S><E><T><Y><F><Y><P><C><P><C><G><D><N><F><S><I><T><K><E><D><L><E><N><G><E><D><V><A><T><C><P><S><C><S><L><I><I><K><V><I><Y><D><K><D><Q><F><V><C><G><E><T><V><P><A><P><S><A><N><K><E><L><V><K><C>
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s
Q96FX2
O60928
KCJ13_HUMAN
Potassium channel, inwardly rectifying subfamily J member 13
Homo
<M><D><S><S><N><C><K><V><I><A><P><L><L><S><Q><R><Y><R><R><M><V><T><K><D><G><H><S><T><L><Q><M><D><G><A><Q><R><G><L><A><Y><L><R><D><A><W><G><I><L><M><D><M><R><W><R><W><M><M><L><V><F><S><A><S><F><V><V><H><W><L><V><F><A><V><L><W><Y><V><L><A><E><M><N><G><D><L><E><L><D><H><D><A><P><P><E><N><H><T><I><C><V><K><Y><I><T><S><F><T><A><A><F><S><F><S><L><E><T><Q><L><T><I><G><Y><G><T><M><F><P><S><G><D><C><P><S><A><I><A><L><L><A><I><Q><M><L><L><G><L><M><L><E><A><F><I><T><G><A><F><V><A><K><I><A><R><P><K><N><R><A><F><S><I><R><F><T><D><T><A><V><V><A><H><M><D><G><K><P><N><L><I><F><Q><V><A><N><T><R><P><S><P><L><T><S><V><R><V><S><A><V><L><Y><Q><E><R><E><N><G><K><L><Y><Q><T><S><V><D><F><H><L><D><G><I><S><S><D><E><C><P><F><F><I><F><P><L><T><Y><Y><H><S><I><T><P><S><S><P><L><A><T><L><L><Q><H><E><N><P><S><H><F><E><L><V><V><F><L><S><A><M><Q><E><G><T><G><E><I><C><Q><R><R><T><S><Y><L><P><S><E><I><M><L><H><H><C><F><A><S><L><L><T><R><G><S><K><G><E><Y><Q><I><K><M><E><N><F><D><K><T><V><P><E><F><P><T><P><L><V><S><K><S><P><N><R><T><D><L><D><I><H><I><N><G><Q><S><I><D><N><F><Q><I><S><E><T><G><L><T><E>
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.<BOP>
O60928
P14653
HXB1_HUMAN
Homeobox protein Hox-2I
Homo
<M><D><Y><N><R><M><N><S><F><L><E><Y><P><L><C><N><R><G><P><S><A><Y><S><A><H><S><A><P><T><S><F><P><P><S><S><A><Q><A><V><D><S><Y><A><S><E><G><R><Y><G><G><G><L><S><S><P><A><F><Q><Q><N><S><G><Y><P><A><Q><Q><P><P><S><T><L><G><V><P><F><P><S><S><A><P><S><G><Y><A><P><A><A><C><S><P><S><Y><G><P><S><Q><Y><Y><P><L><G><Q><S><E><G><D><G><G><Y><F><H><P><S><S><Y><G><A><Q><L><G><G><L><S><D><G><Y><G><A><G><G><A><G><P><G><P><Y><P><P><Q><H><P><P><Y><G><N><E><Q><T><A><S><F><A><P><A><Y><A><D><L><L><S><E><D><K><E><T><P><C><P><S><E><P><N><T><P><T><A><R><T><F><D><W><M><K><V><K><R><N><P><P><K><T><A><K><V><S><E><P><G><L><G><S><P><S><G><L><R><T><N><F><T><T><R><Q><L><T><E><L><E><K><E><F><H><F><N><K><Y><L><S><R><A><R><R><V><E><I><A><A><T><L><E><L><N><E><T><Q><V><K><I><W><F><Q><N><R><R><M><K><Q><K><K><R><E><R><E><E><G><R><V><P><P><A><P><P><G><C><P><K><E><A><A><G><D><A><S><D><Q><S><T><C><T><S><P><E><A><S><P><S><S><V><T><S>
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.<BOP>
P14653
Q9NV56
MRGBP_HUMAN
Up-regulated in colon cancer 4
Homo
<M><G><E><A><E><V><G><G><G><G><A><A><G><D><K><G><P><G><E><A><A><T><S><P><A><E><E><T><V><V><W><S><P><E><V><E><V><C><L><F><H><A><M><L><G><H><K><P><V><G><V><N><R><H><F><H><M><I><C><I><R><D><K><F><S><Q><N><I><G><R><Q><V><P><S><K><V><I><W><D><H><L><S><T><M><Y><D><M><Q><A><L><H><E><S><E><I><L><P><F><P><N><P><E><R><N><F><V><L><P><E><E><I><I><Q><E><V><R><E><G><K><V><M><I><E><E><E><M><K><E><E><M><K><E><D><V><D><P><H><N><G><A><D><D><V><F><S><S><S><G><S><L><G><K><A><S><E><K><S><S><K><D><K><E><K><N><S><S><D><L><G><C><K><E><G><A><D><K><R><K><R><S><R><V><T><D><K><V><L><T><A><N><S><N><P><S><S><P><S><A><A><K><R><R><R><T>
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<BOP>
Q9NV56
Q86UD3
MARH3_HUMAN
RING-type E3 ubiquitin transferase MARCHF3
Homo
<M><T><T><S><R><C><S><H><L><P><E><V><L><P><D><C><T><S><S><A><A><P><V><V><K><T><V><E><D><C><G><S><L><V><N><G><Q><P><Q><Y><V><M><Q><V><S><A><K><D><G><Q><L><L><S><T><V><V><R><T><L><A><T><Q><S><P><F><N><D><R><P><M><C><R><I><C><H><E><G><S><S><Q><E><D><L><L><S><P><C><E><C><T><G><T><L><G><T><I><H><R><S><C><L><E><H><W><L><S><S><S><N><T><S><Y><C><E><L><C><H><F><R><F><A><V><E><R><K><P><R><P><L><V><E><W><L><R><N><P><G><P><Q><H><E><K><R><T><L><F><G><D><M><V><C><F><L><F><I><T><P><L><A><T><I><S><G><W><L><C><L><R><G><A><V><D><H><L><H><F><S><S><R><L><E><A><V><G><L><I><A><L><T><V><A><L><F><T><I><Y><L><F><W><T><L><V><S><F><R><Y><H><C><R><L><Y><N><E><W><R><R><T><N><Q><R><V><I><L><L><I><P><K><S><V><N><V><P><S><N><Q><P><S><L><L><G><L><H><S><V><K><R><N><S><K><E><T><V><V>
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.<BOP>
Q86UD3
Q99747
SNAG_HUMAN
N-ethylmaleimide-sensitive factor attachment protein gamma
Homo
<M><A><A><Q><K><I><N><E><G><L><E><H><L><A><K><A><E><K><Y><L><K><T><G><F><L><K><W><K><P><D><Y><D><S><A><A><S><E><Y><G><K><A><A><V><A><F><K><N><A><K><Q><F><E><Q><A><K><D><A><C><L><R><E><A><V><A><H><E><N><N><R><A><L><F><H><A><A><K><A><Y><E><Q><A><G><M><M><L><K><E><M><Q><K><L><P><E><A><V><Q><L><I><E><K><A><S><M><M><Y><L><E><N><G><T><P><D><T><A><A><M><A><L><E><R><A><G><K><L><I><E><N><V><D><P><E><K><A><V><Q><L><Y><Q><Q><T><A><N><V><F><E><N><E><E><R><L><R><Q><A><V><E><L><L><G><K><A><S><R><L><L><V><R><G><R><R><F><D><E><A><A><L><S><I><Q><K><E><K><N><I><Y><K><E><I><E><N><Y><P><T><C><Y><K><K><T><I><A><Q><V><L><V><H><L><H><R><N><D><Y><V><A><A><E><R><C><V><R><E><S><Y><S><I><P><G><F><N><G><S><E><D><C><A><A><L><E><Q><L><L><E><G><Y><D><Q><Q><D><Q><D><Q><V><S><D><V><C><N><S><P><L><F><K><Y><M><D><N><D><Y><A><K><L><G><L><S><L><V><V><P><G><G><G><I><K><K><K><S><P><A><T><P><Q><A><K><P><D><G><V><T><A><T><A><A><D><E><E><E><D><E><Y><S><G><G><L><C>
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.<BOP>
Q99747
P03923
NU6M_HUMAN
NADH dehydrogenase subunit 6
Homo
<M><M><Y><A><L><F><L><L><S><V><G><L><V><M><G><F><V><G><F><S><S><K><P><S><P><I><Y><G><G><L><V><L><I><V><S><G><V><V><G><C><V><I><I><L><N><F><G><G><G><Y><M><G><L><M><V><F><L><I><Y><L><G><G><M><M><V><V><F><G><Y><T><T><A><M><A><I><E><E><Y><P><E><A><W><G><S><G><V><E><V><L><V><S><V><L><V><G><L><A><M><E><V><G><L><V><L><W><V><K><E><Y><D><G><V><V><V><V><V><N><F><N><S><V><G><S><W><M><I><Y><E><G><E><G><S><G><L><I><R><E><D><P><I><G><A><G><A><L><Y><D><Y><G><R><W><L><V><V><V><T><G><W><T><L><F><V><G><V><Y><I><V><I><E><I><A><R><G><N>
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity and assembly of complex I .<BOP>
P03923
Q8NGX6
O10R2_HUMAN
Olfactory receptor OR1-8
Homo
<M><P><Q><I><L><I><F><T><Y><L><N><M><F><Y><F><F><P><P><L><Q><I><L><A><E><N><L><T><M><V><T><E><F><L><L><L><G><F><S><S><L><G><E><I><Q><L><A><L><F><V><V><F><L><F><L><Y><L><V><I><L><S><G><N><V><T><I><I><S><V><I><H><L><D><K><S><L><H><T><P><M><Y><F><F><L><G><I><L><S><T><S><E><T><F><Y><T><F><V><I><L><P><K><M><L><I><N><L><L><S><V><A><R><T><I><S><F><N><C><C><A><L><Q><M><F><F><F><L><G><F><A><I><T><N><C><L><L><L><G><V><M><G><Y><D><R><Y><A><A><I><C><H><P><L><H><Y><P><T><L><M><S><W><Q><V><C><G><K><L><A><A><A><C><A><I><G><G><F><L><A><S><L><T><V><V><N><L><V><F><S><L><P><F><C><S><A><N><K><V><N><H><Y><F><C><D><I><S><A><V><I><L><L><A><C><T><N><T><D><V><N><E><F><V><I><F><I><C><G><V><L><V><L><V><V><P><F><L><F><I><C><V><S><Y><L><C><I><L><R><T><I><L><K><I><P><S><A><E><G><R><R><K><A><F><S><T><C><A><S><H><L><S><V><V><I><V><H><Y><G><C><A><S><F><I><Y><L><R><P><T><A><N><Y><V><S><N><K><D><R><L><V><T><V><T><Y><T><I><V><T><P><L><L><N><P><M><V><Y><S><L><R><N><K><D><V><Q><L><A><I><R><K><V><L><G><K><K><G><S><L><K><L><Y><N>
Odorant receptor.<BOP>
Q8NGX6
Q9NRN9
METL5_HUMAN
Methyltransferase-like protein 5
Homo
<M><K><K><V><R><L><K><E><L><E><S><R><L><Q><Q><V><D><G><F><E><K><P><K><L><L><L><E><Q><Y><P><T><R><P><H><I><A><A><C><M><L><Y><T><I><H><N><T><Y><D><D><I><E><N><K><V><V><A><D><L><G><C><G><C><G><V><L><S><I><G><T><A><M><L><G><A><G><L><C><V><G><F><D><I><D><E><D><A><L><E><I><F><N><R><N><A><E><E><F><E><L><T><N><I><D><M><V><Q><C><D><V><C><L><L><S><N><R><M><S><K><S><F><D><T><V><I><M><N><P><P><F><G><T><K><N><N><K><G><T><D><M><A><F><L><K><T><A><L><E><M><A><R><T><A><V><Y><S><L><H><K><S><S><T><R><E><H><V><Q><K><K><A><A><E><W><K><I><K><I><D><I><I><A><E><L><R><Y><D><L><P><A><S><Y><K><F><H><K><K><K><S><V><D><I><E><V><D><L><I><R><F><S><F>
Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA . N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation .<BOP>
Q9NRN9
P13693
TCTP_HUMAN
p23
Homo
<M><I><I><Y><R><D><L><I><S><H><D><E><M><F><S><D><I><Y><K><I><R><E><I><A><D><G><L><C><L><E><V><E><G><K><M><V><S><R><T><E><G><N><I><D><D><S><L><I><G><G><N><A><S><A><E><G><P><E><G><E><G><T><E><S><T><V><I><T><G><V><D><I><V><M><N><H><H><L><Q><E><T><S><F><T><K><E><A><Y><K><K><Y><I><K><D><Y><M><K><S><I><K><G><K><L><E><E><Q><R><P><E><R><V><K><P><F><M><T><G><A><A><E><Q><I><K><H><I><L><A><N><F><K><N><Y><Q><F><F><I><G><E><N><M><N><P><D><G><M><V><A><L><L><D><Y><R><E><D><G><V><T><P><Y><M><I><F><F><K><D><G><L><E><M><E><K><C>
Involved in calcium binding and microtubule stabilization.<BOP>
P13693
Q9H0B8
CRLD2_HUMAN
LCCL domain-containing cysteine-rich secretory protein 2
Homo
<M><S><C><V><L><G><G><V><I><P><L><G><L><L><F><L><V><C><G><S><Q><G><Y><L><L><P><N><V><T><L><L><E><E><L><L><S><K><Y><Q><H><N><E><S><H><S><R><V><R><R><A><I><P><R><E><D><K><E><E><I><L><M><L><H><N><K><L><R><G><Q><V><Q><P><Q><A><S><N><M><E><Y><M><T><W><D><D><E><L><E><K><S><A><A><A><W><A><S><Q><C><I><W><E><H><G><P><T><S><L><L><V><S><I><G><Q><N><L><G><A><H><W><G><R><Y><R><S><P><G><F><H><V><Q><S><W><Y><D><E><V><K><D><Y><T><Y><P><Y><P><S><E><C><N><P><W><C><P><E><R><C><S><G><P><M><C><T><H><Y><T><Q><I><V><W><A><T><T><N><K><I><G><C><A><V><N><T><C><R><K><M><T><V><W><G><E><V><W><E><N><A><V><Y><F><V><C><N><Y><S><P><K><G><N><W><I><G><E><A><P><Y><K><N><G><R><P><C><S><E><C><P><P><S><Y><G><G><S><C><R><N><N><L><C><Y><R><E><E><T><Y><T><P><K><P><E><T><D><E><M><N><E><V><E><T><A><P><I><P><E><E><N><H><V><W><L><Q><P><R><V><M><R><P><T><K><P><K><K><T><S><A><V><N><Y><M><T><Q><V><V><R><C><D><T><K><M><K><D><R><C><K><G><S><T><C><N><R><Y><Q><C><P><A><G><C><L><N><H><K><A><K><I><F><G><T><L><F><Y><E><S><S><S><S><I><C><R><A><A><I><H><Y><G><I><L><D><D><K><G><G><L><V><D><I><T><R><N><G><K><V><P><F><F><V><K><S><E><R><H><G><V><Q><S><L><S><K><Y><K><P><S><S><S><F><M><V><S><K><V><K><V><Q><D><L><D><C><Y><T><T><V><A><Q><L><C><P><F><E><K><P><A><T><H><C><P><R><I><H><C><P><A><H><C><K><D><E><P><S><Y><W><A><P><V><F><G><T><N><I><Y><A><D><T><S><S><I><C><K><T><A><V><H><A><G><V><I><S><N><E><S><G><G><D><V><D><V><M><P><V><D><K><K><K><T><Y><V><G><S><L><R><N><G><V><Q><S><E><S><L><G><T><P><R><D><G><K><A><F><R><I><F><A><V><R><Q>
Promotes matrix assembly.<BOP>
Q9H0B8
Q05519
SRS11_HUMAN
Splicing factor, arginine/serine-rich 11
Homo
<M><S><N><T><T><V><V><P><S><T><A><G><P><G><P><S><G><G><P><G><G><G><G><G><G><G><G><G><G><G><G><T><E><V><I><Q><V><T><N><V><S><P><S><A><S><S><E><Q><M><R><T><L><F><G><F><L><G><K><I><D><E><L><R><L><F><P><P><D><D><S><P><L><P><V><S><S><R><V><C><F><V><K><F><H><D><P><D><S><A><V><V><A><Q><H><L><T><N><T><V><F><V><D><R><A><L><I><V><V><P><Y><A><E><G><V><I><P><D><E><A><K><A><L><S><L><L><A><P><A><N><A><V><A><G><L><L><P><G><G><G><L><L><P><T><P><N><P><L><T><Q><I><G><A><V><P><L><A><A><L><G><A><P><T><L><D><P><A><L><A><A><L><G><L><P><G><A><N><L><N><S><Q><S><L><A><A><D><Q><L><L><K><L><M><S><T><V><D><P><K><L><N><H><V><A><A><G><L><V><S><P><S><L><K><S><D><T><S><S><K><E><I><E><E><A><M><K><R><V><R><E><A><Q><S><L><I><S><A><A><I><E><P><D><K><K><E><E><K><R><R><H><S><R><S><R><S><R><S><R><R><R><R><T><P><S><S><S><R><H><R><R><S><R><S><R><S><R><R><R><S><H><S><K><S><R><S><R><R><R><S><K><S><P><R><R><R><R><S><H><S><R><E><R><G><R><R><S><R><S><T><S><K><T><R><D><K><K><K><E><D><K><E><K><K><R><S><K><T><P><P><K><S><Y><S><T><A><R><R><S><R><S><A><S><R><E><R><R><R><R><R><S><R><S><G><T><R><S><P><K><K><P><R><S><P><K><R><K><L><S><R><S><P><S><P><R><R><H><K><K><E><K><K><K><D><K><D><K><E><R><S><R><D><E><R><E><R><S><T><S><K><K><K><K><S><K><D><K><E><K><D><R><E><R><K><S><E><S><D><K><D><V><K><Q><V><T><R><D><Y><D><E><E><E><Q><G><Y><D><S><E><K><E><K><K><E><E><K><K><P><I><E><T><G><S><P><K><T><K><E><C><S><V><E><K><G><T><G><D><S><L><R><E><S><K><V><N><G><D><D><H><H><E><E><D><M><D><M><S><D>
May function in pre-mRNA splicing.<BOP>
Q05519
P36382
CXA5_HUMAN
Connexin-40
Homo
<M><G><D><W><S><F><L><G><N><F><L><E><E><V><H><K><H><S><T><V><V><G><K><V><W><L><T><V><L><F><I><F><R><M><L><V><L><G><T><A><A><E><S><S><W><G><D><E><Q><A><D><F><R><C><D><T><I><Q><P><G><C><Q><N><V><C><Y><D><Q><A><F><P><I><S><H><I><R><Y><W><V><L><Q><I><I><F><V><S><T><P><S><L><V><Y><M><G><H><A><M><H><T><V><R><M><Q><E><K><R><K><L><R><E><A><E><R><A><K><E><V><R><G><S><G><S><Y><E><Y><P><V><A><E><K><A><E><L><S><C><W><E><E><G><N><G><R><I><A><L><Q><G><T><L><L><N><T><Y><V><C><S><I><L><I><R><T><T><M><E><V><G><F><I><V><G><Q><Y><F><I><Y><G><I><F><L><T><T><L><H><V><C><R><R><S><P><C><P><H><P><V><N><C><Y><V><S><R><P><T><E><K><N><V><F><I><V><F><M><L><A><V><A><A><L><S><L><L><L><S><L><A><E><L><Y><H><L><G><W><K><K><I><R><Q><R><F><V><K><P><R><Q><H><M><A><K><C><Q><L><S><G><P><S><V><G><I><V><Q><S><C><T><P><P><P><D><F><N><Q><C><L><E><N><G><P><G><G><K><F><F><N><P><F><S><N><N><M><A><S><Q><Q><N><T><D><N><L><V><T><E><Q><V><R><G><Q><E><Q><T><P><G><E><G><F><I><Q><V><R><Y><G><Q><K><P><E><V><P><N><G><V><S><P><G><H><R><L><P><H><G><Y><H><S><D><K><R><R><L><S><K><A><S><S><K><A><R><S><D><D><L><S><V>
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.<BOP>
P36382
A0A1B0GX95
TVB74_HUMAN
T cell receptor beta variable 7-4
Homo
<M><G><T><R><L><L><C><W><V><V><L><G><F><L><G><T><D><H><T><G><A><G><V><S><Q><S><P><R><Y><K><V><A><K><R><G><R><D><V><A><L><R><C><D><S><I><S><G><H><V><T><L><Y><W><Y><R><Q><T><L><G><Q><G><S><E><V><L><T><Y><S><Q><S><D><A><Q><R><D><K><S><G><R><P><S><G><R><F><S><A><E><R><P><E><R><S><V><S><T><L><K><I><Q><R><T><E><Q><G><D><S><A><V><Y><L><C><A><S><S><L>
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A1B0GX95
Q07866
KLC1_HUMAN
Kinesin light chain 1
Homo
<M><Y><D><N><M><S><T><M><V><Y><I><K><E><D><K><L><E><K><L><T><Q><D><E><I><I><S><K><T><K><Q><V><I><Q><G><L><E><A><L><K><N><E><H><N><S><I><L><Q><S><L><L><E><T><L><K><C><L><K><K><D><D><E><S><N><L><V><E><E><K><S><N><M><I><R><K><S><L><E><M><L><E><L><G><L><S><E><A><Q><V><M><M><A><L><S><N><H><L><N><A><V><E><S><E><K><Q><K><L><R><A><Q><V><R><R><L><C><Q><E><N><Q><W><L><R><D><E><L><A><N><T><Q><Q><K><L><Q><K><S><E><Q><S><V><A><Q><L><E><E><E><K><K><H><L><E><F><M><N><Q><L><K><K><Y><D><D><D><I><S><P><S><E><D><K><D><T><D><S><T><K><E><P><L><D><D><L><F><P><N><D><E><D><D><P><G><Q><G><I><Q><Q><Q><H><S><S><A><A><A><A><A><Q><Q><G><G><Y><E><I><P><A><R><L><R><T><L><H><N><L><V><I><Q><Y><A><S><Q><G><R><Y><E><V><A><V><P><L><C><K><Q><A><L><E><D><L><E><K><T><S><G><H><D><H><P><D><V><A><T><M><L><N><I><L><A><L><V><Y><R><D><Q><N><K><Y><K><D><A><A><N><L><L><N><D><A><L><A><I><R><E><K><T><L><G><K><D><H><P><A><V><A><A><T><L><N><N><L><A><V><L><Y><G><K><R><G><K><Y><K><E><A><E><P><L><C><K><R><A><L><E><I><R><E><K><V><L><G><K><D><H><P><D><V><A><K><Q><L><N><N><L><A><L><L><C><Q><N><Q><G><K><Y><E><E><V><E><Y><Y><Y><Q><R><A><L><E><I><Y><Q><T><K><L><G><P><D><D><P><N><V><A><K><T><K><N><N><L><A><S><C><Y><L><K><Q><G><K><F><K><Q><A><E><T><L><Y><K><E><I><L><T><R><A><H><E><R><E><F><G><S><V><D><D><E><N><K><P><I><W><M><H><A><E><E><R><E><E><C><K><G><K><Q><K><D><G><T><S><F><G><E><Y><G><G><W><Y><K><A><C><K><V><D><S><P><T><V><T><T><T><L><K><N><L><G><A><L><Y><R><R><Q><G><K><F><E><A><A><E><T><L><E><E><A><A><M><R><S><R><K><Q><G><L><D><N><V><H><K><Q><R><V><A><E><V><L><N><D><P><E><N><M><E><K><R><R><S><R><E><S><L><N><V><D><V><V><K><Y><E><S><G><P><D><G><G><E><E><V><S><M><S><V><E><W><N><G><G><V><S><G><R><A><S><F><C><G><K><R><Q><Q><Q><Q><W><P><G><R><R><H><R>
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.<BOP>
Q07866
Q86WV1
SKAP1_HUMAN
Src kinase-associated phosphoprotein of 55 kDa
Homo
<M><Q><A><A><A><L><P><E><E><I><R><W><L><L><E><D><A><E><E><F><L><A><E><G><L><R><N><E><N><L><S><A><V><A><R><D><H><R><D><H><I><L><R><G><F><Q><Q><I><K><A><R><Y><Y><W><D><F><Q><P><Q><G><G><D><I><G><Q><D><S><S><D><D><N><H><S><G><T><L><G><L><S><L><T><S><D><A><P><F><L><S><D><Y><Q><D><E><G><M><E><D><I><V><K><G><A><Q><E><L><D><N><V><I><K><Q><G><Y><L><E><K><K><S><K><D><H><S><F><F><G><S><E><W><Q><K><R><W><C><V><V><S><R><G><L><F><Y><Y><Y><A><N><E><K><S><K><Q><P><K><G><T><F><L><I><K><G><Y><G><V><R><M><A><P><H><L><R><R><D><S><K><K><E><S><C><F><E><L><T><S><Q><D><R><R><S><Y><E><F><T><A><T><S><P><A><E><A><R><D><W><V><D><Q><I><S><F><L><L><K><D><L><S><S><L><T><I><P><Y><E><E><D><E><E><E><E><E><K><E><E><T><Y><D><D><I><D><G><F><D><S><P><S><C><G><S><Q><C><R><P><T><I><L><P><G><S><V><G><I><K><E><P><T><E><E><K><E><E><E><D><I><Y><E><V><L><P><D><E><E><H><D><L><E><E><D><E><S><G><T><R><R><K><G><V><D><Y><A><S><Y><Y><Q><G><L><W><D><C><H><G><D><Q><P><D><E><L><S><F><Q><R><G><D><L><I><R><I><L><S><K><E><Y><N><M><Y><G><W><W><V><G><E><L><N><S><L><V><G><I><V><P><K><E><Y><L><T><T><A><F><E><V><E><E><R>
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.<BOP>
Q86WV1
P0C7L1
ISK8_HUMAN
Serine protease inhibitor Kazal-type 8
Homo
<M><K><G><I><C><S><D><A><I><L><V><L><A><T><S><M><W><M><A><F><A><I><D><F><P><L><P><M><A><S><E><R><G><Q><L><D><K><T><I><V><E><C><L><K><N><V><N><K><C><W><F><L><S><Y><I><K><P><S><E><P><I><C><G><S><D><Q><V><T><Y><S><S><D><C><H><L><C><S><K><I><L><F><E><G><L><N><I><T><K><L><Y><D><G><Q><C><E><N><S>
Probable serine protease inhibitor.<BOP>
P0C7L1
P61328
FGF12_HUMAN
Myocyte-activating factor
Homo
<M><A><A><A><I><A><S><S><L><I><R><Q><K><R><Q><A><R><E><S><N><S><D><R><V><S><A><S><K><R><R><S><S><P><S><K><D><G><R><S><L><C><E><R><H><V><L><G><V><F><S><K><V><R><F><C><S><G><R><K><R><P><V><R><R><R><P><E><P><Q><L><K><G><I><V><T><R><L><F><S><Q><Q><G><Y><F><L><Q><M><H><P><D><G><T><I><D><G><T><K><D><E><N><S><D><Y><T><L><F><N><L><I><P><V><G><L><R><V><V><A><I><Q><G><V><K><A><S><L><Y><V><A><M><N><G><E><G><Y><L><Y><S><S><D><V><F><T><P><E><C><K><F><K><E><S><V><F><E><N><Y><Y><V><I><Y><S><S><T><L><Y><R><Q><Q><E><S><G><R><A><W><F><L><G><L><N><K><E><G><Q><I><M><K><G><N><R><V><K><K><T><K><P><S><S><H><F><V><P><K><P><I><E><V><C><M><Y><R><E><P><S><L><H><E><I><G><E><K><Q><G><R><S><R><K><S><S><G><T><P><T><M><N><G><G><K><V><V><N><Q><D><S><T>
Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.<BOP>
P61328
P19793
RXRA_HUMAN
Retinoid X receptor alpha
Homo
<M><D><T><K><H><F><L><P><L><D><F><S><T><Q><V><N><S><S><L><T><S><P><T><G><R><G><S><M><A><A><P><S><L><H><P><S><L><G><P><G><I><G><S><P><G><Q><L><H><S><P><I><S><T><L><S><S><P><I><N><G><M><G><P><P><F><S><V><I><S><S><P><M><G><P><H><S><M><S><V><P><T><T><P><T><L><G><F><S><T><G><S><P><Q><L><S><S><P><M><N><P><V><S><S><S><E><D><I><K><P><P><L><G><L><N><G><V><L><K><V><P><A><H><P><S><G><N><M><A><S><F><T><K><H><I><C><A><I><C><G><D><R><S><S><G><K><H><Y><G><V><Y><S><C><E><G><C><K><G><F><F><K><R><T><V><R><K><D><L><T><Y><T><C><R><D><N><K><D><C><L><I><D><K><R><Q><R><N><R><C><Q><Y><C><R><Y><Q><K><C><L><A><M><G><M><K><R><E><A><V><Q><E><E><R><Q><R><G><K><D><R><N><E><N><E><V><E><S><T><S><S><A><N><E><D><M><P><V><E><R><I><L><E><A><E><L><A><V><E><P><K><T><E><T><Y><V><E><A><N><M><G><L><N><P><S><S><P><N><D><P><V><T><N><I><C><Q><A><A><D><K><Q><L><F><T><L><V><E><W><A><K><R><I><P><H><F><S><E><L><P><L><D><D><Q><V><I><L><L><R><A><G><W><N><E><L><L><I><A><S><F><S><H><R><S><I><A><V><K><D><G><I><L><L><A><T><G><L><H><V><H><R><N><S><A><H><S><A><G><V><G><A><I><F><D><R><V><L><T><E><L><V><S><K><M><R><D><M><Q><M><D><K><T><E><L><G><C><L><R><A><I><V><L><F><N><P><D><S><K><G><L><S><N><P><A><E><V><E><A><L><R><E><K><V><Y><A><S><L><E><A><Y><C><K><H><K><Y><P><E><Q><P><G><R><F><A><K><L><L><L><R><L><P><A><L><R><S><I><G><L><K><C><L><E><H><L><F><F><F><K><L><I><G><D><T><P><I><D><T><F><L><M><E><M><L><E><A><P><H><Q><M><T>
Receptor for retinoic acid that acts as a transcription factor . Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes . The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription . The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid . In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression . On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation . Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA . The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator,
P19793
A0A0U1RRE5
NBDY_HUMAN
Protein NoBody
Homo
<M><G><D><Q><P><C><A><S><G><R><S><T><L><P><P><G><N><A><R><E><A><K><P><P><K><K><R><C><L><L><A><P><R><W><D><Y><P><E><G><T><P><N><G><G><S><T><T><L><P><S><A><P><P><P><A><S><A><G><L><K><S><H><P><P><P><P><E><K>
Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process.<BOP>
A0A0U1RRE5
Q8N720
ZN655_HUMAN
Vav-interacting Krueppel-like protein
Homo
<M><E><E><I><P><A><Q><E><A><A><G><S><P><R><V><Q><F><Q><S><L><E><T><Q><S><E><C><L><S><P><E><P><Q><F><V><Q><D><T><D><M><E><Q><G><L><T><G><D><G><E><T><R><E><E><N><K><L><L><I><P><K><Q><K><I><S><E><E><V><H><S><Y><K><V><R><V><G><R><L><K><H><D><I><T><Q><V><P><E><T><R><E><V><Y><K><S><E><D><R><L><E><R><L><Q><E><I><L><R><K><F><L><Y><L><E><R><E><F><R><Q><I><T><I><S><K><E><T><F><T><S><E><K><N><N><E><C><H><E><P><E><K><S><F><S><L><D><S><T><I><D><A><D><Q><R><V><L><R><I><Q><N><T><D><D><N><D><K><Y><D><M><S><F><N><Q><N><S><A><S><G><K><H><E><H><L><N><L><T><E><D><F><Q><S><S><E><C><K><E><S><L><M><D><L><S><H><L><N><K><W><E><S><I><P><N><T><E><K><S><Y><K><C><D><V><C><G><K><I><F><H><Q><S><S><A><L><T><R><H><Q><R><I><H><T><R><E><K><P><Y><K><C><K><E><C><E><K><S><F><S><Q><S><S><S><L><S><R><H><K><R><I><H><T><R><E><K><P><Y><K><C><E><A><S><D><K><S><C><E><A><S><D><K><S><C><S><P><S><S><G><I><I><Q><H><K><K><I><H><T><R><A><K><S><Y><K><C><S><S><C><E><R><V><F><S><R><S><V><H><L><T><Q><H><Q><K><I><H><K><E><M><P><C><K><C><T><V><C><G><S><D><F><C><H><T><S><Y><L><L><E><H><Q><R><V><H><H><E><E><K><A><Y><E><Y><D><E><Y><G><L><A><Y><I><K><Q><Q><G><I><H><F><R><E><K><P><Y><T><C><S><E><C><G><K><D><F><R><L><N><S><H><L><I><Q><H><Q><R><I><H><T><G><E><K><A><H><E><C><N><E><C><G><K><A><F><S><Q><T><S><C><L><I><Q><H><H><K><M><H><R><K><E><K><S><Y><E><C><N><E><Y><E><G><S><F><S><H><S><S><D><L><I><L><Q><Q><E><V><L><T><R><Q><K><A><F><D><C><D><V><W><E><K><N><S><S><Q><R><A><H><L><V><Q><H><Q><S><I><H><T><K><E><N><S>
May be involved in transcriptional regulation.<BOP>
Q8N720
A0A075B6S4
KVD17_HUMAN
Immunoglobulin kappa variable 1D-17
Homo
<M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><F><P><G><A><R><C><N><I><Q><M><T><Q><S><P><S><A><M><S><A><S><V><G><D><R><V><T><I><T><C><R><A><R><Q><G><I><S><N><Y><L><A><W><F><Q><Q><K><P><G><K><V><P><K><H><L><I><Y><A><A><S><S><L><Q><S><G><V><P><S><R><F><S><G><S><G><S><G><T><E><F><T><L><T><I><S><S><L><Q><P><E><D><F><A><T><Y><Y><C><L><Q><H><N><S><Y><P>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A075B6S4
Q8TEA1
NSUN6_HUMAN
NOL1/NOP2/Sun domain family member 6
Homo
<M><S><I><F><P><K><I><S><L><R><P><E><V><E><N><Y><L><K><E><G><F><M><N><K><E><I><V><T><A><L><G><K><Q><E><A><E><R><K><F><E><T><L><L><K><H><L><S><H><P><P><S><F><T><T><V><R><V><N><T><H><L><A><S><V><Q><H><V><K><N><L><L><L><D><E><L><Q><K><Q><F><N><G><L><S><V><P><I><L><Q><H><P><D><L><Q><D><V><L><L><I><P><V><I><G><P><R><K><N><I><K><K><Q><Q><C><E><A><I><V><G><A><Q><C><G><N><A><V><L><R><G><A><H><V><Y><A><P><G><I><V><S><A><S><Q><F><M><K><A><G><D><V><I><S><V><Y><S><D><I><K><G><K><C><K><K><G><A><K><E><F><D><G><T><K><V><F><L><G><N><G><I><S><E><L><S><R><K><E><I><F><S><G><L><P><E><L><K><G><M><G><I><R><M><T><E><P><V><Y><L><S><P><S><F><D><S><V><L><P><R><Y><L><F><L><Q><N><L><P><S><A><L><V><S><H><V><L><N><P><Q><P><G><E><K><I><L><D><L><C><A><A><P><G><G><K><T><T><H><I><A><A><L><M><H><D><Q><G><E><V><I><A><L><D><K><I><F><N><K><V><E><K><I><K><Q><N><A><L><L><L><G><L><N><S><I><R><A><F><C><F><D><G><T><K><A><V><K><L><D><M><V><E><D><T><E><G><E><P><P><F><L><P><E><S><F><D><R><I><L><L><D><A><P><C><S><G><M><G><Q><R><P><N><M><A><C><T><W><S><V><K><E><V><A><S><Y><Q><P><L><Q><R><K><L><F><T><A><A><V><Q><L><L><K><P><E><G><V><L><V><Y><S><T><C><T><I><T><L><A><E><N><E><E><Q><V><A><W><A><L><T><K><F><P><C><L><Q><L><Q><P><Q><E><P><Q><I><G><G><E><G><M><R><G><A><G><L><S><C><E><Q><L><K><Q><L><Q><R><F><D><P><S><A><V><P><L><P><D><T><D><M><D><S><L><R><E><A><R><R><E><D><M><L><R><L><A><N><K><D><S><I><G><F><F><I><A><K><F><V><K><C><K><S><T>
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) . In vitro also methylates tRNA(Thr)(AGT) . Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates .<BOP>
Q8TEA1
P29371
NK3R_HUMAN
Tachykinin receptor 3
Homo
<M><A><T><L><P><A><A><E><T><W><I><D><G><G><G><G><V><G><A><D><A><V><N><L><T><A><S><L><A><A><G><A><A><T><G><A><V><E><T><G><W><L><Q><L><L><D><Q><A><G><N><L><S><S><S><P><S><A><L><G><L><P><V><A><S><P><A><P><S><Q><P><W><A><N><L><T><N><Q><F><V><Q><P><S><W><R><I><A><L><W><S><L><A><Y><G><V><V><V><A><V><A><V><L><G><N><L><I><V><I><W><I><I><L><A><H><K><R><M><R><T><V><T><N><Y><F><L><V><N><L><A><F><S><D><A><S><M><A><A><F><N><T><L><V><N><F><I><Y><A><L><H><S><E><W><Y><F><G><A><N><Y><C><R><F><Q><N><F><F><P><I><T><A><V><F><A><S><I><Y><S><M><T><A><I><A><V><D><R><Y><M><A><I><I><D><P><L><K><P><R><L><S><A><T><A><T><K><I><V><I><G><S><I><W><I><L><A><F><L><L><A><F><P><Q><C><L><Y><S><K><T><K><V><M><P><G><R><T><L><C><F><V><Q><W><P><E><G><P><K><Q><H><F><T><Y><H><I><I><V><I><I><L><V><Y><C><F><P><L><L><I><M><G><I><T><Y><T><I><V><G><I><T><L><W><G><G><E><I><P><G><D><T><C><D><K><Y><H><E><Q><L><K><A><K><R><K><V><V><K><M><M><I><I><V><V><M><T><F><A><I><C><W><L><P><Y><H><I><Y><F><I><L><T><A><I><Y><Q><Q><L><N><R><W><K><Y><I><Q><Q><V><Y><L><A><S><F><W><L><A><M><S><S><T><M><Y><N><P><I><I><Y><C><C><L><N><K><R><F><R><A><G><F><K><R><A><F><R><W><C><P><F><I><K><V><S><S><Y><D><E><L><E><L><K><T><T><R><F><H><P><N><R><Q><S><S><M><Y><T><V><T><R><M><E><S><M><T><V><V><F><D><P><N><D><A><D><T><T><R><S><S><R><K><K><R><A><T><P><R><D><P><S><F><N><G><C><S><R><R><N><S><K><S><A><S><A><T><S><S><F><I><S><S><P><Y><T><S><V><D><E><Y><S>
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.<BOP>
P29371
Q7L8J4
3BP5L_HUMAN
SH3 domain-binding protein 5-like
Homo
<M><A><E><L><R><Q><V><P><G><G><R><E><T><P><Q><G><E><L><R><P><E><V><V><E><D><E><V><P><R><S><P><V><A><E><E><P><G><G><G><G><S><S><S><S><E><A><K><L><S><P><R><E><E><E><E><L><D><P><R><I><Q><E><E><L><E><H><L><N><Q><A><S><E><E><I><N><Q><V><E><L><Q><L><D><E><A><R><T><T><Y><R><R><I><L><Q><E><S><A><R><K><L><N><T><Q><G><S><H><L><G><S><C><I><E><K><A><R><P><Y><Y><E><A><R><R><L><A><K><E><A><Q><Q><E><T><Q><K><A><A><L><R><Y><E><R><A><V><S><M><H><N><A><A><R><E><M><V><F><V><A><E><Q><G><V><M><A><D><K><N><R><L><D><P><T><W><Q><E><M><L><N><H><A><T><C><K><V><N><E><A><E><E><E><R><L><R><G><E><R><E><H><Q><R><V><T><R><L><C><Q><Q><A><E><A><R><V><Q><A><L><Q><K><T><L><R><R><A><I><G><K><S><R><P><Y><F><E><L><K><A><Q><F><S><Q><I><L><E><E><H><K><A><K><V><T><E><L><E><Q><Q><V><A><Q><A><K><T><R><Y><S><V><A><L><R><N><L><E><Q><I><S><E><Q><I><H><A><R><R><R><G><G><L><P><P><H><P><L><G><P><R><R><S><S><P><V><G><A><E><A><G><P><E><D><M><E><D><G><D><S><G><I><E><G><A><E><G><A><G><L><E><E><G><S><S><L><G><P><G><P><A><P><D><T><D><T><L><S><L><L><S><L><R><T><V><A><S><D><L><Q><K><C><D><S><V><E><H><L><R><G><L><S><D><H><V><S><L><D><G><Q><E><L><G><T><R><S><G><G><R><R><G><S><D><G><G><A><R><G><G><R><H><Q><R><S><V><S><L>
Functions as guanine nucleotide exchange factor (GEF) for RAB11A.<BOP>
Q7L8J4
P51512
MMP16_HUMAN
Membrane-type-3 matrix metalloproteinase
Homo
<M><I><L><L><T><F><S><T><G><R><R><L><D><F><V><H><H><S><G><V><F><F><L><Q><T><L><L><W><I><L><C><A><T><V><C><G><T><E><Q><Y><F><N><V><E><V><W><L><Q><K><Y><G><Y><L><P><P><T><D><P><R><M><S><V><L><R><S><A><E><T><M><Q><S><A><L><A><A><M><Q><Q><F><Y><G><I><N><M><T><G><K><V><D><R><N><T><I><D><W><M><K><K><P><R><C><G><V><P><D><Q><T><R><G><S><S><K><F><H><I><R><R><K><R><Y><A><L><T><G><Q><K><W><Q><H><K><H><I><T><Y><S><I><K><N><V><T><P><K><V><G><D><P><E><T><R><K><A><I><R><R><A><F><D><V><W><Q><N><V><T><P><L><T><F><E><E><V><P><Y><S><E><L><E><N><G><K><R><D><V><D><I><T><I><I><F><A><S><G><F><H><G><D><S><S><P><F><D><G><E><G><G><F><L><A><H><A><Y><F><P><G><P><G><I><G><G><D><T><H><F><D><S><D><E><P><W><T><L><G><N><P><N><H><D><G><N><D><L><F><L><V><A><V><H><E><L><G><H><A><L><G><L><E><H><S><N><D><P><T><A><I><M><A><P><F><Y><Q><Y><M><E><T><D><N><F><K><L><P><N><D><D><L><Q><G><I><Q><K><I><Y><G><P><P><D><K><I><P><P><P><T><R><P><L><P><T><V><P><P><H><R><S><I><P><P><A><D><P><R><K><N><D><R><P><K><P><P><R><P><P><T><G><R><P><S><Y><P><G><A><K><P><N><I><C><D><G><N><F><N><T><L><A><I><L><R><R><E><M><F><V><F><K><D><Q><W><F><W><R><V><R><N><N><R><V><M><D><G><Y><P><M><Q><I><T><Y><F><W><R><G><L><P><P><S><I><D><A><V><Y><E><N><S><D><G><N><F><V><F><F><K><G><N><K><Y><W><V><F><K><D><T><T><L><Q><P><G><Y><P><H><D><L><I><T><L><G><S><G><I><P><P><H><G><I><D><S><A><I><W><W><E><D><V><G><K><T><Y><F><F><K><G><D><R><Y><W><R><Y><S><E><E><M><K><T><M><D><P><G><Y><P><K><P><I><T><V><W><K><G><I><P><E><S><P><Q><G><A><F><V><H><K><E><N><G><F><T><Y><F><Y><K><G><K><E><Y><W><K><F><N><N><Q><I><L><K><V><E><P><G><Y><P><R><S><I><L><K><D><F><M><G><C><D><G><P><T><D><R><V><K><E><G><H><S><P><P><D><D><V><D><I><V><I><K><L><D><N><T><A><S><T><V><K><A><I><A><I><V><I><P><C><I><L><A><L><C><L><L><V><L><V><Y><T><V><F><Q><F><K><R><K><G><T><P><R><H><I><L><Y><C><K><R><S><M><Q><E><W><V>
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.<BOP>
P51512
O15218
GP182_HUMAN
G-protein coupled receptor 182
Homo
<M><S><V><K><P><S><W><G><P><G><P><S><E><G><V><T><A><V><P><T><S><D><L><G><E><I><H><N><W><T><E><L><L><D><L><F><N><H><T><L><S><E><C><H><V><E><L><S><Q><S><T><K><R><V><V><L><F><A><L><Y><L><A><M><F><V><V><G><L><V><E><N><L><L><V><I><C><V><N><W><R><G><S><G><R><A><G><L><M><N><L><Y><I><L><N><M><A><I><A><D><L><G><I><V><L><S><L><P><V><W><M><L><E><V><T><L><D><Y><T><W><L><W><G><S><F><S><C><R><F><T><H><Y><F><Y><F><V><N><M><Y><S><S><I><F><F><L><V><C><L><S><V><D><R><Y><V><T><L><T><S><A><S><P><S><W><Q><R><Y><Q><H><R><V><R><R><A><M><C><A><G><I><W><V><L><S><A><I><I><P><L><P><E><V><V><H><I><Q><L><V><E><G><P><E><P><M><C><L><F><M><A><P><F><E><T><Y><S><T><W><A><L><A><V><A><L><S><T><T><I><L><G><F><L><L><P><F><P><L><I><T><V><F><N><V><L><T><A><C><R><L><R><Q><P><G><Q><P><K><S><R><R><H><C><L><L><L><C><A><Y><V><A><V><F><V><M><C><W><L><P><Y><H><V><T><L><L><L><L><T><L><H><G><T><H><I><S><L><H><C><H><L><V><H><L><L><Y><F><F><Y><D><V><I><D><C><F><S><M><L><H><C><V><I><N><P><I><L><Y><N><F><L><S><P><H><F><R><G><R><L><L><N><A><V><V><H><Y><L><P><K><D><Q><T><K><A><G><T><C><A><S><S><S><S><C><S><T><Q><H><S><I><I><I><T><K><G><D><S><Q><P><A><A><A><A><P><H><P><E><P><S><L><S><F><Q><A><H><H><L><L><P><N><T><S><P><I><S><P><T><Q><P><L><T><P><S>
Orphan receptor.<BOP>
O15218
Q5XUX1
FBXW9_HUMAN
F-box and WD-40 domain-containing protein 9
Homo
<M><E><L><P><L><G><R><C><D><D><S><R><T><W><D><D><D><S><D><P><E><S><E><T><D><P><D><A><Q><A><K><A><Y><V><A><R><V><L><S><P><P><K><S><G><L><A><F><S><R><P><S><Q><L><S><T><P><A><A><S><P><S><A><S><E><P><R><A><A><S><R><V><S><A><V><S><E><P><G><L><L><S><L><P><P><E><L><L><L><E><I><C><S><Y><L><D><A><R><L><V><L><H><V><L><S><R><V><C><H><A><L><R><D><L><V><S><D><H><V><T><W><R><L><R><A><L><R><R><V><R><A><P><Y><P><V><V><E><E><K><N><F><D><W><P><A><A><C><I><A><L><E><Q><H><L><S><R><W><A><E><D><G><R><W><V><E><Y><F><C><L><A><E><G><H><V><A><S><V><D><S><V><L><L><L><Q><G><G><S><L><C><L><S><G><S><R><D><R><N><V><N><L><W><D><L><R><Q><L><G><T><E><S><N><Q><V><L><I><K><T><L><G><T><K><R><N><S><T><H><E><G><W><V><W><S><L><A><A><Q><D><H><R><V><C><S><G><S><W><D><S><T><V><K><L><W><D><M><A><A><D><G><Q><Q><F><G><E><I><K><A><S><S><A><V><L><C><L><S><Y><L><P><D><I><L><V><T><G><T><Y><D><K><K><V><T><I><Y><D><P><R><A><G><P><A><L><L><K><H><Q><Q><L><H><S><R><P><V><L><T><L><L><A><D><D><R><H><I><I><S><G><S><E><D><H><T><L><V><V><V><D><R><R><A><N><S><V><L><Q><R><L><Q><L><D><S><Y><L><L><C><M><S><Y><Q><E><P><Q><L><W><A><G><D><N><Q><G><L><L><H><V><F><A><N><R><N><G><C><F><Q><L><I><R><S><F><D><V><G><H><S><F><P><I><T><G><I><Q><Y><S><V><G><A><L><Y><T><T><S><T><D><K><T><I><R><V><H><V><P><T><D><P><P><R><T><I><C><T><R><R><H><D><N><G><L><N><R><V><C><A><E><G><N><L><V><V><A><G><S><G><D><L><S><L><E><V><W><R><L><Q><A>
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP>
Q5XUX1
P04808
REL1_HUMAN
Relaxin A chain
Homo
<M><P><R><L><F><L><F><H><L><L><E><F><C><L><L><L><N><Q><F><S><R><A><V><A><A><K><W><K><D><D><V><I><K><L><C><G><R><E><L><V><R><A><Q><I><A><I><C><G><M><S><T><W><S><K><R><S><L><S><Q><E><D><A><P><Q><T><P><R><P><V><A><E><I><V><P><S><F><I><N><K><D><T><E><T><I><I><I><M><L><E><F><I><A><N><L><P><P><E><L><K><A><A><L><S><E><R><Q><P><S><L><P><E><L><Q><Q><Y><V><P><A><L><K><D><S><N><L><S><F><E><E><F><K><K><L><I><R><N><R><Q><S><E><A><A><D><S><N><P><S><E><L><K><Y><L><G><L><D><T><H><S><Q><K><K><R><R><P><Y><V><A><L><F><E><K><C><C><L><I><G><C><T><K><R><S><L><A><K><Y><C>
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.<BOP>
P04808
Q96RE7
NACC1_HUMAN
BTB/POZ domain-containing protein 14B
Homo
<M><A><Q><T><L><Q><M><E><I><P><N><F><G><N><S><I><L><E><C><L><N><E><Q><R><L><Q><G><L><Y><C><D><V><S><V><V><V><K><G><H><A><F><K><A><H><R><A><V><L><A><A><S><S><S><Y><F><R><D><L><F><N><N><S><R><S><A><V><V><E><L><P><A><A><V><Q><P><Q><S><F><Q><Q><I><L><S><F><C><Y><T><G><R><L><S><M><N><V><G><D><Q><F><L><L><M><Y><T><A><G><F><L><Q><I><Q><E><I><M><E><K><G><T><E><F><F><L><K><V><S><S><P><S><C><D><S><Q><G><L><H><A><E><E><A><P><S><S><E><P><Q><S><P><V><A><Q><T><S><G><W><P><A><C><S><T><P><L><P><L><V><S><R><V><K><T><E><Q><Q><E><S><D><S><V><Q><C><M><P><V><A><K><R><L><W><D><S><G><Q><K><E><A><G><G><G><G><N><G><S><R><K><M><A><K><F><S><T><P><D><L><A><A><N><R><P><H><Q><P><P><P><P><Q><Q><A><P><V><V><A><A><A><Q><P><A><V><A><A><G><A><G><Q><P><A><G><G><V><A><A><A><G><G><V><V><S><G><P><S><T><S><E><R><T><S><P><G><T><S><S><A><Y><T><S><D><S><P><G><S><Y><H><N><E><E><D><E><E><E><D><G><G><E><E><G><M><D><E><Q><Y><R><Q><I><C><N><M><Y><T><M><Y><S><M><M><N><V><G><Q><T><A><E><K><V><E><A><L><P><E><Q><V><A><P><E><S><R><N><R><I><R><V><R><Q><D><L><A><S><L><P><A><E><L><I><N><Q><I><G><N><R><C><H><P><K><L><Y><D><E><G><D><P><S><E><K><L><E><L><V><T><G><T><N><V><Y><I><T><R><A><Q><L><M><N><C><H><V><S><A><G><T><R><H><K><V><L><L><R><R><L><L><A><S><F><F><D><R><N><T><L><A><N><S><C><G><T><G><I><R><S><S><T><N><D><P><R><R><K><P><L><D><S><R><V><L><H><A><V><K><Y><Y><C><Q><N><F><A><P><N><F><K><E><S><E><M><N><A><I><A><A><D><M><C><T><N><A><R><R><V><V><R><K><S><W><M><P><K><V><K><V><L><K><A><E><D><D><A><Y><T><T><F><I><S><E><T><G><K><I><E><P><D><M><M><G><V><E><H><G><F><E><T><A><S><H><E><G><E><A><G><P><S><A><E><A><L><Q>
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.<BOP>
Q96RE7
Q13520
AQP6_HUMAN
Kidney-specific aquaporin
Homo
<M><D><A><V><E><P><G><G><R><G><W><A><S><M><L><A><C><R><L><W><K><A><I><S><R><A><L><F><A><E><F><L><A><T><G><L><Y><V><F><F><G><V><G><S><V><M><R><W><P><T><A><L><P><S><V><L><Q><I><A><I><T><F><N><L><V><T><A><M><A><V><Q><V><T><W><K><A><S><G><A><H><A><N><P><A><V><T><L><A><F><L><V><G><S><H><I><S><L><P><R><A><V><A><Y><V><A><A><Q><L><V><G><A><T><V><G><A><A><L><L><Y><G><V><M><P><G><D><I><R><E><T><L><G><I><N><V><V><R><N><S><V><S><T><G><Q><A><V><A><V><E><L><L><L><T><L><Q><L><V><L><C><V><F><A><S><T><D><S><R><Q><T><S><G><S><P><A><T><M><I><G><I><S><V><A><L><G><H><L><I><G><I><H><F><T><G><C><S><M><N><P><A><R><S><F><G><P><A><I><I><I><G><K><F><T><V><H><W><V><F><W><V><G><P><L><M><G><A><L><L><A><S><L><I><Y><N><F><V><L><F><P><D><T><K><T><L><A><Q><R><L><A><I><L><T><G><T><V><E><V><G><T><G><A><G><A><G><A><E><P><L><K><K><E><S><Q><P><G><S><G><A><V><E><M><E><S><V>
Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.<BOP>
Q13520
Q96FM1
PGAP3_HUMAN
PER1-like domain-containing protein 1
Homo
<M><A><G><L><A><A><R><L><V><L><L><A><G><A><A><A><L><A><S><G><S><Q><G><D><R><E><P><V><Y><R><D><C><V><L><Q><C><E><E><Q><N><C><S><G><G><A><L><N><H><F><R><S><R><Q><P><I><Y><M><S><L><A><G><W><T><C><R><D><D><C><K><Y><E><C><M><W><V><T><V><G><L><Y><L><Q><E><G><H><K><V><P><Q><F><H><G><K><W><P><F><S><R><F><L><F><F><Q><E><P><A><S><A><V><A><S><F><L><N><G><L><A><S><L><V><M><L><C><R><Y><R><T><F><V><P><A><S><S><P><M><Y><H><T><C><V><A><F><A><W><V><S><L><N><A><W><F><W><S><T><V><F><H><T><R><D><T><D><L><T><E><K><M><D><Y><F><C><A><S><T><V><I><L><H><S><I><Y><L><C><C><V><R><T><V><G><L><Q><H><P><A><V><V><S><A><F><R><A><L><L><L><L><M><L><T><V><H><V><S><Y><L><S><L><I><R><F><D><Y><G><Y><N><L><V><A><N><V><A><I><G><L><V><N><V><V><W><W><L><A><W><C><L><W><N><Q><R><R><L><P><H><V><R><K><C><V><V><V><V><L><L><L><Q><G><L><S><L><L><E><L><L><D><F><P><P><L><F><W><V><L><D><A><H><A><I><W><H><I><S><T><I><P><V><H><V><L><F><F><S><F><L><E><D><D><S><L><Y><L><L><K><E><S><E><D><K><F><K><L><D>
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI.<BOP>
Q96FM1
P07355
ANXA2_HUMAN
p36
Homo
<M><S><T><V><H><E><I><L><C><K><L><S><L><E><G><D><H><S><T><P><P><S><A><Y><G><S><V><K><A><Y><T><N><F><D><A><E><R><D><A><L><N><I><E><T><A><I><K><T><K><G><V><D><E><V><T><I><V><N><I><L><T><N><R><S><N><A><Q><R><Q><D><I><A><F><A><Y><Q><R><R><T><K><K><E><L><A><S><A><L><K><S><A><L><S><G><H><L><E><T><V><I><L><G><L><L><K><T><P><A><Q><Y><D><A><S><E><L><K><A><S><M><K><G><L><G><T><D><E><D><S><L><I><E><I><I><C><S><R><T><N><Q><E><L><Q><E><I><N><R><V><Y><K><E><M><Y><K><T><D><L><E><K><D><I><I><S><D><T><S><G><D><F><R><K><L><M><V><A><L><A><K><G><R><R><A><E><D><G><S><V><I><D><Y><E><L><I><D><Q><D><A><R><D><L><Y><D><A><G><V><K><R><K><G><T><D><V><P><K><W><I><S><I><M><T><E><R><S><V><P><H><L><Q><K><V><F><D><R><Y><K><S><Y><S><P><Y><D><M><L><E><S><I><R><K><E><V><K><G><D><L><E><N><A><F><L><N><L><V><Q><C><I><Q><N><K><P><L><Y><F><A><D><R><L><Y><D><S><M><K><G><K><G><T><R><D><K><V><L><I><R><I><M><V><S><R><S><E><V><D><M><L><K><I><R><S><E><F><K><R><K><Y><G><K><S><L><Y><Y><Y><I><Q><Q><D><T><K><G><D><Y><Q><K><A><L><L><Y><L><C><G><G><D><D>
(Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.<BOP>
P07355
Q15615
OR4D1_HUMAN
Olfactory receptor TPCR16
Homo
<M><E><P><Q><N><T><T><Q><V><S><M><F><V><L><L><G><F><S><Q><T><Q><E><L><Q><K><F><L><F><L><L><F><L><L><V><Y><V><T><T><I><V><G><N><L><L><I><M><V><T><V><T><F><D><C><R><L><H><T><P><M><Y><F><L><L><R><N><L><A><L><I><D><L><C><Y><S><T><V><T><S><P><K><M><L><V><D><F><L><H><E><T><K><T><I><S><Y><Q><G><C><M><A><Q><I><F><F><F><H><L><L><G><G><G><T><V><F><F><L><S><V><M><A><Y><D><R><Y><I><A><I><S><Q><P><L><R><Y><V><T><I><M><N><T><Q><L><C><V><G><L><V><V><A><A><W><V><G><G><F><V><H><S><I><V><Q><L><A><L><I><L><P><L><P><F><C><G><P><N><I><L><D><N><F><Y><C><D><V><P><Q><V><L><R><L><A><C><T><D><T><S><L><L><E><F><L><M><I><S><N><S><G><L><L><V><I><I><W><F><L><L><L><L><I><S><Y><T><V><I><L><V><M><L><R><S><H><S><G><K><A><R><R><K><A><A><S><T><C><T><T><H><I><I><V><V><S><M><I><F><I><P><C><I><Y><I><Y><T><W><P><F><T><P><F><L><M><D><K><A><V><S><I><S><Y><T><V><M><T><P><M><L><N><P><M><I><Y><T><L><R><N><Q><D><M><K><A><A><M><R><R><L><G><K><C><L><V><I><C><R><E>
Odorant receptor.<BOP>
Q15615
Q9H6T3
RPAP3_HUMAN
RNA polymerase II-associated protein 3
Homo
<M><T><S><A><N><K><A><I><E><L><Q><L><Q><V><K><Q><N><A><E><E><L><Q><D><F><M><R><D><L><E><N><W><E><K><D><I><K><Q><K><D><M><E><L><R><R><Q><N><G><V><P><E><E><N><L><P><P><I><R><N><G><N><F><R><K><K><K><K><G><K><A><K><E><S><S><K><K><T><R><E><E><N><T><K><N><R><I><K><S><Y><D><Y><E><A><W><A><K><L><D><V><D><R><I><L><D><E><L><D><K><D><D><S><T><H><E><S><L><S><Q><E><S><E><S><E><E><D><G><I><H><V><D><S><Q><K><A><L><V><L><K><E><K><G><N><K><Y><F><K><Q><G><K><Y><D><E><A><I><D><C><Y><T><K><G><M><D><A><D><P><Y><N><P><V><L><P><T><N><R><A><S><A><Y><F><R><L><K><K><F><A><V><A><E><S><D><C><N><L><A><V><A><L><N><R><S><Y><T><K><A><Y><S><R><R><G><A><A><R><F><A><L><Q><K><L><E><E><A><K><K><D><Y><E><R><V><L><E><L><E><P><N><N><F><E><A><T><N><E><L><R><K><I><S><Q><A><L><A><S><K><E><N><S><Y><P><K><E><A><D><I><V><I><K><S><T><E><G><E><R><K><Q><I><E><A><Q><Q><N><K><Q><Q><A><I><S><E><K><D><R><G><N><G><F><F><K><E><G><K><Y><E><R><A><I><E><C><Y><T><R><G><I><A><A><D><G><A><N><A><L><L><P><A><N><R><A><M><A><Y><L><K><I><Q><K><Y><E><E><A><E><K><D><C><T><Q><A><I><L><L><D><G><S><Y><S><K><A><F><A><R><R><G><T><A><R><T><F><L><G><K><L><N><E><A><K><Q><D><F><E><T><V><L><L><L><E><P><G><N><K><Q><A><V><T><E><L><S><K><I><K><K><E><L><I><E><K><G><H><W><D><D><V><F><L><D><S><T><Q><R><Q><N><V><V><K><P><I><D><N><P><P><H><P><G><S><T><K><P><L><K><K><V><I><I><E><E><T><G><N><L><I><Q><T><I><D><V><P><D><S><T><T><A><A><A><P><E><N><N><P><I><N><L><A><N><V><I><A><A><T><G><T><T><S><K><K><N><S><S><Q><D><D><L><F><P><T><S><D><T><P><R><A><K><V><L><K><I><E><E><V><S><D><T><S><S><L><Q><P><Q><A><S><L><K><Q><D><V><C><Q><S><Y><S><E><K><M><P><I><E><I><E><Q><K><P><A><Q><F><A><T><T><V><L><P><P><I><P><A><N><S><F><Q><L><E><S><D><F><R><Q><L><K><S><S><P><D><M><L><Y><Q><Y><L><K><Q><I><E><P><S><L><Y><P><K><L><F><Q><K><N><L><D><P><D><V><F><N><Q><I><V><K><I><L><H><D><F><Y><I><E><K><E><K><P><L><L><I><F><E><I><L><Q><R><L><S><E><L><K><R><F><D><M><A><V><M><F><M><S><E><T><E><K><K><I><A><R><A><L><F><N><H><I><D><K><S><G><L><K><D><S><S><V><E><E><L><K><K><R><Y><G><G>
Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.<BOP>
Q9H6T3
Q9UBR1
BUP1_HUMAN
N-carbamoyl-beta-alanine amidohydrolase
Homo
<M><A><G><A><E><W><K><S><L><E><E><C><L><E><K><H><L><P><L><P><D><L><Q><E><V><K><R><V><L><Y><G><K><E><L><R><K><L><D><L><P><R><E><A><F><E><A><A><S><R><E><D><F><E><L><Q><G><Y><A><F><E><A><A><E><E><Q><L><R><R><P><R><I><V><H><V><G><L><V><Q><N><R><I><P><L><P><A><N><A><P><V><A><E><Q><V><S><A><L><H><R><R><I><K><A><I><V><E><V><A><A><M><C><G><V><N><I><I><C><F><Q><E><A><W><T><M><P><F><A><F><C><T><R><E><K><L><P><W><T><E><F><A><E><S><A><E><D><G><P><T><T><R><F><C><Q><K><L><A><K><N><H><D><M><V><V><V><S><P><I><L><E><R><D><S><E><H><G><D><V><L><W><N><T><A><V><V><I><S><N><S><G><A><V><L><G><K><T><R><K><N><H><I><P><R><V><G><D><F><N><E><S><T><Y><Y><M><E><G><N><L><G><H><P><V><F><Q><T><Q><F><G><R><I><A><V><N><I><C><Y><G><R><H><H><P><L><N><W><L><M><Y><S><I><N><G><A><E><I><I><F><N><P><S><A><T><I><G><A><L><S><E><S><L><W><P><I><E><A><R><N><A><A><I><A><N><H><C><F><T><C><A><I><N><R><V><G><T><E><H><F><P><N><E><F><T><S><G><D><G><K><K><A><H><Q><D><F><G><Y><F><Y><G><S><S><Y><V><A><A><P><D><S><S><R><T><P><G><L><S><R><S><R><D><G><L><L><V><A><K><L><D><L><N><L><C><Q><Q><V><N><D><V><W><N><F><K><M><T><G><R><Y><E><M><Y><A><R><E><L><A><E><A><V><K><S><N><Y><S><P><T><I><V><K><E>
Catalyzes a late step in pyrimidine degradation . Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide . Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable).<BOP>
Q9UBR1
O75610
LFTY1_HUMAN
Protein lefty-B
Homo
<M><Q><P><L><W><L><C><W><A><L><W><V><L><P><L><A><S><P><G><A><A><L><T><G><E><Q><L><L><G><S><L><L><R><Q><L><Q><L><K><E><V><P><T><L><D><R><A><D><M><E><E><L><V><I><P><T><H><V><R><A><Q><Y><V><A><L><L><Q><R><S><H><G><D><R><S><R><G><K><R><F><S><Q><S><F><R><E><V><A><G><R><F><L><A><L><E><A><S><T><H><L><L><V><F><G><M><E><Q><R><L><P><P><N><S><E><L><V><Q><A><V><L><R><L><F><Q><E><P><V><P><K><A><A><L><H><R><H><G><R><L><S><P><R><S><A><R><A><R><V><T><V><E><W><L><R><V><R><D><D><G><S><N><R><T><S><L><I><D><S><R><L><V><S><V><H><E><S><G><W><K><A><F><D><V><T><E><A><V><N><F><W><Q><Q><L><S><R><P><R><Q><P><L><L><L><Q><V><S><V><Q><R><E><H><L><G><P><L><A><S><G><A><H><K><L><V><R><F><A><S><Q><G><A><P><A><G><L><G><E><P><Q><L><E><L><H><T><L><D><L><G><D><Y><G><A><Q><G><D><C><D><P><E><A><P><M><T><E><G><T><R><C><C><R><Q><E><M><Y><I><D><L><Q><G><M><K><W><A><E><N><W><V><L><E><P><P><G><F><L><A><Y><E><C><V><G><T><C><R><Q><P><P><E><A><L><A><F><K><W><P><F><L><G><P><R><Q><C><I><A><S><E><T><D><S><L><P><M><I><V><S><I><K><E><G><G><R><T><R><P><Q><V><V><S><L><P><N><M><R><V><Q><K><C><S><C><A><S><D><G><A><L><V><P><R><R><L><Q><P>
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.<BOP>
O75610
Q9UHA4
LTOR3_HUMAN
Mitogen-activated protein kinase scaffold protein 1
Homo
<M><A><D><D><L><K><R><F><L><Y><K><K><L><P><S><V><E><G><L><H><A><I><V><V><S><D><R><D><G><V><P><V><I><K><V><A><N><D><N><A><P><E><H><A><L><R><P><G><F><L><S><T><F><A><L><A><T><D><Q><G><S><K><L><G><L><S><K><N><K><S><I><I><C><Y><Y><N><T><Y><Q><V><V><Q><F><N><R><L><P><L><V><V><S><F><I><A><S><S><S><A><N><T><G><L><I><V><S><L><E><K><E><L><A><P><L><F><E><E><L><R><Q><V><V><E><V><S>
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<BOP>
Q9UHA4
Q9Y262
EIF3L_HUMAN
Eukaryotic translation initiation factor 3 subunit E-interacting protein
Homo
<M><S><Y><P><A><D><D><Y><E><S><E><A><A><Y><D><P><Y><A><Y><P><S><D><Y><D><M><H><T><G><D><P><K><Q><D><L><A><Y><E><R><Q><Y><E><Q><Q><T><Y><Q><V><I><P><E><V><I><K><N><F><I><Q><Y><F><H><K><T><V><S><D><L><I><D><Q><K><V><Y><E><L><Q><A><S><R><V><S><S><D><V><I><D><Q><K><V><Y><E><I><Q><D><I><Y><E><N><S><W><T><K><L><T><E><R><F><F><K><N><T><P><W><P><E><A><E><A><I><A><P><Q><V><G><N><D><A><V><F><L><I><L><Y><K><E><L><Y><Y><R><H><I><Y><A><K><V><S><G><G><P><S><L><E><Q><R><F><E><S><Y><Y><N><Y><C><N><L><F><N><Y><I><L><N><A><D><G><P><A><P><L><E><L><P><N><Q><W><L><W><D><I><I><D><E><F><I><Y><Q><F><Q><S><F><S><Q><Y><R><C><K><T><A><K><K><S><E><E><E><I><D><F><L><R><S><N><P><K><I><W><N><V><H><S><V><L><N><V><L><H><S><L><V><D><K><S><N><I><N><R><Q><L><E><V><Y><T><S><G><G><D><P><E><S><V><A><G><E><Y><G><R><H><S><L><Y><K><M><L><G><Y><F><S><L><V><G><L><L><R><L><H><S><L><L><G><D><Y><Y><Q><A><I><K><V><L><E><N><I><E><L><N><K><K><S><M><Y><S><R><V><P><E><C><Q><V><T><T><Y><Y><Y><V><G><F><A><Y><L><M><M><R><R><Y><Q><D><A><I><R><V><F><A><N><I><L><L><Y><I><Q><R><T><K><S><M><F><Q><R><T><T><Y><K><Y><E><M><I><N><K><Q><N><E><Q><M><H><A><L><L><A><I><A><L><T><M><Y><P><M><R><I><D><E><S><I><H><L><Q><L><R><E><K><Y><G><D><K><M><L><R><M><Q><K><G><D><P><Q><V><Y><E><E><L><F><S><Y><S><C><P><K><F><L><S><P><V><V><P><N><Y><D><N><V><H><P><N><Y><H><K><E><P><F><L><Q><Q><L><K><V><F><S><D><E><V><Q><Q><Q><A><Q><L><S><T><I><R><S><F><L><K><L><Y><T><T><M><P><V><A><K><L><A><G><F><L><D><L><T><E><Q><E><F><R><I><Q><L><L><V><F><K><H><K><M><K><N><L><V><W><T><S><G><I><S><A><L><D><G><E><F><Q><S><A><S><E><V><D><F><Y><I><D><K><D><M><I><H><I><A><D><T><K><V><A><R><R><Y><G><D><F><F><I><R><Q><I><H><K><F><E><E><L><N><R><T><L><K><K><M><G><Q><R><P>
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 .<BOP>
Q9Y262
O95832
CLD1_HUMAN
Senescence-associated epithelial membrane protein
Homo
<M><A><N><A><G><L><Q><L><L><G><F><I><L><A><F><L><G><W><I><G><A><I><V><S><T><A><L><P><Q><W><R><I><Y><S><Y><A><G><D><N><I><V><T><A><Q><A><M><Y><E><G><L><W><M><S><C><V><S><Q><S><T><G><Q><I><Q><C><K><V><F><D><S><L><L><N><L><S><S><T><L><Q><A><T><R><A><L><M><V><V><G><I><L><L><G><V><I><A><I><F><V><A><T><V><G><M><K><C><M><K><C><L><E><D><D><E><V><Q><K><M><R><M><A><V><I><G><G><A><I><F><L><L><A><G><L><A><I><L><V><A><T><A><W><Y><G><N><R><I><V><Q><E><F><Y><D><P><M><T><P><V><N><A><R><Y><E><F><G><Q><A><L><F><T><G><W><A><A><A><S><L><C><L><L><G><G><A><L><L><C><C><S><C><P><R><K><T><T><S><Y><P><T><P><R><P><Y><P><K><P><A><P><S><S><G><K><D><Y><V>
(Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes . Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell . Acts as a receptor for dengue virus .<BOP>
O95832
Q05BQ5
MBTD1_HUMAN
MBT domain-containing protein 1
Homo
<M><F><D><G><Y><D><S><C><S><E><D><T><S><S><S><S><S><S><E><E><S><E><E><E><V><A><P><L><P><S><N><L><P><I><I><K><N><N><G><Q><V><Y><T><Y><P><D><G><K><S><G><M><A><T><C><E><M><C><G><M><V><G><V><R><D><A><F><Y><S><K><T><K><R><F><C><S><V><S><C><S><R><S><Y><S><S><N><S><K><K><A><S><I><L><A><R><L><Q><G><K><P><P><T><K><K><A><K><V><L><Q><K><Q><P><L><V><A><K><L><A><A><Y><A><Q><Y><Q><A><T><L><Q><N><Q><A><K><T><K><A><A><V><S><M><E><G><F><S><W><G><N><Y><I><N><S><N><S><F><I><A><A><P><V><T><C><F><K><H><A><P><M><G><T><C><W><G><D><I><S><E><N><V><R><V><E><V><P><N><T><D><C><S><L><P><T><K><V><F><W><I><A><G><I><V><K><L><A><G><Y><N><A><L><L><R><Y><E><G><F><E><N><D><S><G><L><D><F><W><C><N><I><C><G><S><D><I><H><P><V><G><W><C><A><A><S><G><K><P><L><V><P><P><R><T><I><Q><H><K><Y><T><N><W><K><A><F><L><V><K><R><L><T><G><A><K><T><L><P><P><D><F><S><Q><K><V><S><E><S><M><Q><Y><P><F><K><P><C><M><R><V><E><V><V><D><K><R><H><L><C><R><T><R><V><A><V><V><E><S><V><I><G><G><R><L><R><L><V><Y><E><E><S><E><D><R><T><D><D><F><W><C><H><M><H><S><P><L><I><H><H><I><G><W><S><R><S><I><G><H><R><F><K><R><S><D><I><T><K><K><Q><D><G><H><F><D><T><P><P><H><L><F><A><K><V><K><E><V><D><Q><S><G><E><W><F><K><E><G><M><K><L><E><A><I><D><P><L><N><L><S><T><I><C><V><A><T><I><R><K><V><L><A><D><G><F><L><M><I><G><I><D><G><S><E><A><A><D><G><S><D><W><F><C><Y><H><A><T><S><P><S><I><F><P><V><G><F><C><E><I><N><M><I><E><L><T><P><P><R><G><Y><T><K><L><P><F><K><W><F><D><Y><L><R><E><T><G><S><I><A><A><P><V><K><L><F><N><K><D><V><P><N><H><G><F><R><V><G><M><K><L><E><A><V><D><L><M><E><P><R><L><I><C><V><A><T><V><T><R><I><I><H><R><L><L><R><I><H><F><D><G><W><E><E><E><Y><D><Q><W><V><D><C><E><S><P><D><L><Y><P><V><G><W><C><Q><L><T><G><Y><Q><L><Q><P><P><A><S><Q><S><S><R><E><N><Q><S><A><S><S><K><Q><K><K><K><A><K><S><Q><Q><Y><K><G><H><K><K><M><T><T><L><Q><L><K><E><E><L><L><D><G><E><D><Y><N><F><L><Q><G><A><S><D><Q><E><S><N><G><S><A><N><F><Y><I><K><Q><E><P>
Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A . The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) . MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively) . In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me . Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR) .<BOP>
Q05BQ5
P01116
RASK_HUMAN
GTPase KRas, N-terminally processed
Homo
<M><T><E><Y><K><L><V><V><V><G><A><G><G><V><G><K><S><A><L><T><I><Q><L><I><Q><N><H><F><V><D><E><Y><D><P><T><I><E><D><S><Y><R><K><Q><V><V><I><D><G><E><T><C><L><L><D><I><L><D><T><A><G><Q><E><E><Y><S><A><M><R><D><Q><Y><M><R><T><G><E><G><F><L><C><V><F><A><I><N><N><T><K><S><F><E><D><I><H><H><Y><R><E><Q><I><K><R><V><K><D><S><E><D><V><P><M><V><L><V><G><N><K><C><D><L><P><S><R><T><V><D><T><K><Q><A><Q><D><L><A><R><S><Y><G><I><P><F><I><E><T><S><A><K><T><R><Q><R><V><E><D><A><F><Y><T><L><V><R><E><I><R><Q><Y><R><L><K><K><I><S><K><E><E><K><T><P><G><C><V><K><I><K><K><C><I><I><M>
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity . Plays an important role in the regulation of cell proliferation . Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner .<BOP>
P01116
P40429
RL13A_HUMAN
Large ribosomal subunit protein uL13
Homo
<M><A><E><V><Q><V><L><V><L><D><G><R><G><H><L><L><G><R><L><A><A><I><V><A><K><Q><V><L><L><G><R><K><V><V><V><V><R><C><E><G><I><N><I><S><G><N><F><Y><R><N><K><L><K><Y><L><A><F><L><R><K><R><M><N><T><N><P><S><R><G><P><Y><H><F><R><A><P><S><R><I><F><W><R><T><V><R><G><M><L><P><H><K><T><K><R><G><Q><A><A><L><D><R><L><K><V><F><D><G><I><P><P><P><Y><D><K><K><K><R><M><V><V><P><A><A><L><K><V><V><R><L><K><P><T><R><K><F><A><Y><L><G><R><L><A><H><E><V><G><W><K><Y><Q><A><V><T><A><T><L><E><E><K><R><K><E><K><A><K><I><H><Y><R><K><K><K><Q><L><M><R><L><R><K><Q><A><E><K><N><V><E><K><K><I><D><K><Y><T><E><V><L><K><T><H><G><L><L><V>
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions . Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes . Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation . In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex . Involved in methylation of rRNA .<BOP>
P40429
Q96S06
LMF1_HUMAN
Transmembrane protein 112
Homo
<M><R><P><D><S><P><T><M><A><A><P><A><E><S><L><R><R><R><K><T><G><Y><S><D><P><E><P><E><S><P><P><A><P><G><R><G><P><A><G><S><P><A><H><L><H><T><G><T><F><W><L><T><R><I><V><L><L><K><A><L><A><F><V><Y><F><V><A><F><L><V><A><F><H><Q><N><K><Q><L><I><G><D><R><G><L><L><P><C><R><V><F><L><K><N><F><Q><Q><Y><F><Q><D><R><T><S><W><E><V><F><S><Y><M><P><T><I><L><W><L><M><D><W><S><D><M><N><S><N><L><D><L><L><A><L><L><G><L><G><I><S><S><F><V><L><I><T><G><C><A><N><M><L><L><M><A><A><L><W><G><L><Y><M><S><L><V><N><V><G><H><V><W><Y><S><F><G><W><E><S><Q><L><L><E><T><G><F><L><G><I><F><L><C><P><L><W><T><L><S><R><L><P><Q><H><T><P><T><S><R><I><V><L><W><G><F><R><W><L><I><F><R><I><M><L><G><A><G><L><I><K><I><R><G><D><R><C><W><R><D><L><T><C><M><D><F><H><Y><E><T><Q><P><M><P><N><P><V><A><Y><Y><L><H><H><S><P><W><W><F><H><R><F><E><T><L><S><N><H><F><I><E><L><L><V><P><F><F><L><F><L><G><R><R><A><C><I><I><H><G><V><L><Q><I><L><F><Q><A><V><L><I><V><S><G><N><L><S><F><L><N><W><L><T><M><V><P><S><L><A><C><F><D><D><A><T><L><G><F><L><F><P><S><G><P><G><S><L><K><D><R><V><L><Q><M><Q><R><D><I><R><G><A><R><P><E><P><R><F><G><S><V><V><R><R><A><A><N><V><S><L><G><V><L><L><A><W><L><S><V><P><V><V><L><N><L><L><S><S><R><Q><V><M><N><T><H><F><N><S><L><H><I><V><N><T><Y><G><A><F><G><S><I><T><K><E><R><A><E><V><I><L><Q><G><T><A><S><S><N><A><S><A><P><D><A><M><W><E><D><Y><E><F><K><C><K><P><G><D><P><S><R><R><P><C><L><I><S><P><Y><H><Y><R><L><D><W><L><M><W><F><A><A><F><Q><T><Y><E><H><N><D><W><I><I><H><L><A><G><K><L><L><A><S><D><A><E><A><L><S><L><L><A><H><N><P><F><A><G><R><P><P><P><R><W><V><R><G><E><H><Y><R><Y><K><F><S><R><P><G><G><R><H><A><A><E><G><K><W><W><V><R><K><R><I><G><A><Y><F><P><P><L><S><L><E><E><L><R><P><Y><F><R><D><R><G><W><P><L><P><G><P><L>
Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL.<BOP>
Q96S06
Q6ZR62
RTL4_HUMAN
Zinc finger CCHC domain-containing protein 16
Homo
<M><E><K><C><T><K><S><S><S><T><M><Q><V><E><P><S><F><L><Q><A><E><N><L><I><L><R><L><Q><M><Q><H><P><T><T><E><N><T><A><K><R><G><Q><V><M><P><A><L><A><T><T><V><M><P><V><P><Y><S><L><E><H><L><T><Q><F><H><G><D><P><A><N><C><S><E><F><L><T><Q><V><T><T><Y><L><T><A><L><Q><I><S><N><P><A><N><D><A><Q><I><K><L><F><F><D><Y><L><S><Q><Q><L><E><S><C><G><I><I><S><G><P><D><K><S><T><L><L><K><Q><Y><E><N><L><I><L><E><F><Q><Q><S><F><G><K><P><T><K><Q><E><I><N><P><L><M><N><A><K><F><D><K><G><D><N><S><S><Q><Q><D><P><A><T><F><H><L><L><A><Q><N><L><I><C><N><E><T><N><Q><S><G><Q><F><E><K><A><L><A><D><P><N><Q><D><E><E><S><V><T><D><M><M><D><N><L><P><D><L><I><T><Q><C><I><Q><L><D><K><K><H><S><D><R><P><E><L><L><Q><S><E><T><Q><L><P><L><L><A><S><L><I><Q><H><Q><A><L><F><S><P><T><D><P><P><P><K><K><G><P><I><Q><L><R><E><G><Q><L><P><L><T><P><A><K><R><A><R><Q><Q><E><T><Q><L><C><L><Y><C><S><Q><S><G><H><F><T><R><D><C><L><A><K><R><S><R><A><P><A><T><T><N><N><T><A><H><Q>
Involved in cognitive function in the brain, possibly via the noradrenergic system.<BOP>
Q6ZR62
Q8NC24
RELL2_HUMAN
RELT-like protein 2
Homo
<M><S><E><P><Q><P><D><L><E><P><P><Q><H><G><L><Y><M><L><F><L><L><V><L><V><F><F><L><M><G><L><V><G><F><M><I><C><H><V><L><K><K><K><G><Y><R><C><R><T><S><R><G><S><E><P><D><D><A><Q><L><Q><P><P><E><D><D><D><M><N><E><D><T><V><E><R><I><V><R><C><I><I><Q><N><E><A><N><A><E><A><L><K><E><M><L><G><D><S><E><G><E><G><T><V><Q><L><S><S><V><D><A><T><S><S><L><Q><D><G><A><P><S><H><H><H><T><V><H><L><G><S><A><A><P><C><L><H><C><S><R><S><K><R><P><P><L><V><R><Q><G><R><S><K><E><G><K><S><R><P><R><T><G><E><T><T><V><F><S><V><G><R><F><R><V><T><H><I><E><K><R><Y><G><L><H><E><H><R><D><G><S><P><T><D><R><S><W><G><S><G><G><G><Q><D><P><G><G><G><Q><G><S><G><G><G><Q><P><K><A><G><M><P><A><M><E><R><L><P><P><E><R><P><Q><P><Q><V><L><A><S><P><P><V><Q><N><G><G><L><R><D><S><S><L><T><P><R><A><L><E><G><N><P><R><A><S><A><E><P><T><L><R><A><G><G><R><G><P><S><P><G><L><P><T><Q><E><A><N><G><Q><P><S><K><P><D><T><S><D><H><Q><V><S><L><P><Q><G><A><G><S><M>
Induces activation of MAPK14/p38 cascade, when overexpressed . Induces apoptosis, when overexpressed .<BOP>
Q8NC24
Q6IS24
GLT17_HUMAN
Williams-Beuren syndrome chromosomal region 17 protein
Homo
<M><A><S><L><R><R><V><K><V><L><L><V><L><N><L><I><A><V><A><G><F><V><L><F><L><A><K><C><R><P><I><A><V><R><S><G><D><A><F><H><E><I><R><P><R><A><E><V><A><N><L><S><A><H><S><A><S><P><I><Q><D><A><V><L><K><R><L><S><L><L><E><D><I><V><Y><R><Q><L><N><G><L><S><K><S><L><G><L><I><E><G><Y><G><G><R><G><K><G><G><L><P><A><T><L><S><P><A><E><E><E><K><A><K><G><P><H><E><K><Y><G><Y><N><S><Y><L><S><E><K><I><S><L><D><R><S><I><P><D><Y><R><P><T><K><C><K><E><L><K><Y><S><K><D><L><P><Q><I><S><I><I><F><I><F><V><N><E><A><L><S><V><I><L><R><S><V><H><S><A><V><N><H><T><P><T><H><L><L><K><E><I><I><L><V><D><D><N><S><D><E><E><E><L><K><V><P><L><E><E><Y><V><H><K><R><Y><P><G><L><V><K><V><V><R><N><Q><K><R><E><G><L><I><R><A><R><I><E><G><W><K><V><A><T><G><Q><V><T><G><F><F><D><A><H><V><E><F><T><A><G><W><A><E><P><V><L><S><R><I><Q><E><N><R><K><R><V><I><L><P><S><I><D><N><I><K><Q><D><N><F><E><V><Q><R><Y><E><N><S><A><H><G><Y><S><W><E><L><W><C><M><Y><I><S><P><P><K><D><W><W><D><A><G><D><P><S><L><P><I><R><T><P><A><M><I><G><C><S><F><V><V><N><R><K><F><F><G><E><I><G><L><L><D><P><G><M><D><V><Y><G><G><E><N><I><E><L><G><I><K><V><W><L><C><G><G><S><M><E><V><L><P><C><S><R><V><A><H><I><E><R><K><K><K><P><Y><N><S><N><I><G><F><Y><T><K><R><N><A><L><R><V><A><E><V><W><M><D><D><Y><K><S><H><V><Y><I><A><W><N><L><P><L><E><N><P><G><I><D><I><G><D><V><S><E><R><R><A><L><R><K><S><L><K><C><K><N><F><Q><W><Y><L><D><H><V><Y><P><E><M><R><R><Y><N><N><T><V><A><Y><G><E><L><R><N><N><K><A><K><D><V><C><L><D><Q><G><P><L><E><N><H><T><A><I><L><Y><P><C><H><G><W><G><P><Q><L><A><R><Y><T><K><E><G><F><L><H><L><G><A><L><G><T><T><T><L><L><P><D><T><R><C><L><V><D><N><S><K><S><R><L><P><Q><L><L><D><C><D><K><V><K><S><S><L><Y><K><R><W><N><F><I><Q><N><G><A><I><M><N><K><G><T><G><R><C><L><E><V><E><N><R><G><L><A><G><I><D><L><I><L><R><S><C><T><G><Q><R><W><T><I><K><N><S><I><K>
May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.<BOP>
Q6IS24
P78362
SRPK2_HUMAN
SRSF protein kinase 2 C-terminal
Homo
<M><S><V><N><S><E><K><S><S><S><S><E><R><P><E><P><Q><Q><K><A><P><L><V><P><P><P><P><P><P><P><P><P><P><P><P><P><L><P><D><P><T><P><P><E><P><E><E><E><I><L><G><S><D><D><E><E><Q><E><D><P><A><D><Y><C><K><G><G><Y><H><P><V><K><I><G><D><L><F><N><G><R><Y><H><V><I><R><K><L><G><W><G><H><F><S><T><V><W><L><C><W><D><M><Q><G><K><R><F><V><A><M><K><V><V><K><S><A><Q><H><Y><T><E><T><A><L><D><E><I><K><L><L><K><C><V><R><E><S><D><P><S><D><P><N><K><D><M><V><V><Q><L><I><D><D><F><K><I><S><G><M><N><G><I><H><V><C><M><V><F><E><V><L><G><H><H><L><L><K><W><I><I><K><S><N><Y><Q><G><L><P><V><R><C><V><K><S><I><I><R><Q><V><L><Q><G><L><D><Y><L><H><S><K><C><K><I><I><H><T><D><I><K><P><E><N><I><L><M><C><V><D><D><A><Y><V><R><R><M><A><A><E><A><T><E><W><Q><K><A><G><A><P><P><P><S><G><S><A><V><S><T><A><P><Q><Q><K><P><I><G><K><I><S><K><N><K><K><K><K><L><K><K><K><Q><K><R><Q><A><E><L><L><E><K><R><L><Q><E><I><E><E><L><E><R><E><A><E><R><K><I><I><E><E><N><I><T><S><A><A><P><S><N><D><Q><D><G><E><Y><C><P><E><V><K><L><K><T><T><G><L><E><E><A><A><E><A><E><T><A><K><D><N><G><E><A><E><D><Q><E><E><K><E><D><A><E><K><E><N><I><E><K><D><E><D><D><V><D><Q><E><L><A><N><I><D><P><T><W><I><E><S><P><K><T><N><G><H><I><E><N><G><P><F><S><L><E><Q><Q><L><D><D><E><D><D><D><E><E><D><C><P><N><P><E><E><Y><N><L><D><E><P><N><A><E><S><D><Y><T><Y><S><S><S><Y><E><Q><F><N><G><E><L><P><N><G><R><H><K><I><P><E><S><Q><F><P><E><F><S><T><S><L><F><S><G><S><L><E><P><V><A><C><G><S><V><L><S><E><G><S><P><L><T><E><Q><E><E><S><S><P><S><H><D><R><S><R><T><V><S><A><S><S><T><G><D><L><P><K><A><K><T><R><A><A><D><L><L><V><N><P><L><D><P><R><N><A><D><K><I><R><V><K><I><A><D><L><G><N><A><C><W><V><H><K><H><F><T><E><D><I><Q><T><R><Q><Y><R><S><I><E><V><L><I><G><A><G><Y><S><T><P><A><D><I><W><S><T><A><C><M><A><F><E><L><A><T><G><D><Y><L><F><E><P><H><S><G><E><D><Y><S><R><D><E><D><H><I><A><H><I><I><E><L><L><G><S><I><P><R><H><F><A><L><S><G><K><Y><S><R><E><F><F><N><R><R><G><E><L><R><H><I><T><K><L><K><P><W><S><L><F><D><V><L><V><E><K><Y><G><W><P><H><E><D><A><A><Q><F><T><D><F><L><I><P><M><L><E><M><V><P><E><K><R><A><S><A><G><E><C><L><R><H><P><W><L><N><S>
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing . Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression . This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression . Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation . Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 . Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA . Can mediate hepatitis B virus (HBV) core protein phosphorylation . Plays a
P78362
Q5JTD0
TJAP1_HUMAN
Tight junction protein 4
Homo
<M><T><S><A><A><P><A><K><K><P><Y><R><K><A><P><P><E><H><R><E><L><R><L><E><I><P><G><S><R><L><E><Q><E><E><P><L><T><D><A><E><R><M><K><L><L><Q><E><E><N><E><E><L><R><R><R><L><A><S><A><T><R><R><T><E><A><L><E><R><E><L><E><I><G><Q><D><C><L><E><L><E><L><G><Q><S><R><E><E><L><D><K><F><K><D><K><F><R><R><L><Q><N><S><Y><T><A><S><Q><R><T><N><Q><E><L><E><D><K><L><H><T><L><A><S><L><S><H><S><W><I><F><A><I><K><K><A><E><M><D><R><K><T><L><D><W><E><I><V><E><L><T><N><K><L><L><D><A><K><N><T><I><N><K><L><E><E><L><N><E><R><Y><R><L><D><C><N><L><A><V><Q><L><L><K><C><N><K><S><H><F><R><N><H><K><F><A><D><L><P><C><E><L><Q><D><M><V><R><K><H><L><H><S><G><Q><E><A><A><S><P><G><P><A><P><S><L><A><P><G><A><V><V><P><T><S><V><I><A><R><V><L><E><K><P><E><S><L><L><L><N><S><A><Q><S><G><S><A><G><R><P><L><A><E><D><V><F><V><H><V><D><M><S><E><G><V><P><G><D><P><A><S><P><P><A><P><G><S><P><T><P><Q><P><N><G><E><C><H><S><L><G><T><A><R><G><S><P><E><E><E><L><P><L><P><A><F><E><K><L><N><P><Y><P><T><P><S><P><P><H><P><L><Y><P><G><R><R><V><I><E><F><S><E><D><K><V><R><I><P><R><N><S><P><L><P><N><C><T><Y><A><T><R><Q><A><I><S><L><S><L><V><E><E><G><S><E><R><A><R><P><S><P><V><P><S><T><P><A><S><A><Q><A><S><P><H><H><Q><P><S><P><A><P><L><T><L><S><A><P><A><S><S><A><S><S><E><E><D><L><L><V><S><W><Q><R><A><F><V><D><R><T><P><P><P><A><A><V><A><Q><R><T><A><F><G><R><D><A><L><P><E><L><Q><R><H><F><A><H><S><P><A><D><R><D><E><V><V><Q><A><P><S><A><R><P><E><E><S><E><L><L><L><P><T><E><P><D><S><G><F><P><R><E><E><E><E><L><N><L><P><I><S><P><E><E><E><R><Q><S><L><L><P><I><N><R><G><T><E><E><G><P><G><T><S><H><T><E><G><R><A><W><P><L><P><S><S><S><R><P><Q><R><S><P><K><R><M><G><V><H><H><L><H><R><K><D><S><L><T><Q><A><Q><E><Q><G><N><L><L><N>
Plays a role in regulating the structure of the Golgi apparatus.<BOP>
Q5JTD0
P48167
GLRB_HUMAN
Glycine receptor 58 kDa subunit
Homo
<M><K><F><L><L><T><T><A><F><L><I><L><I><S><L><W><V><E><E><A><Y><S><K><E><K><S><S><K><K><G><K><G><K><K><K><Q><Y><L><C><P><S><Q><Q><S><A><E><D><L><A><R><V><P><A><N><S><T><S><N><I><L><N><R><L><L><V><S><Y><D><P><R><I><R><P><N><F><K><G><I><P><V><D><V><V><V><N><I><F><I><N><S><F><G><S><I><Q><E><T><T><M><D><Y><R><V><N><I><F><L><R><Q><K><W><N><D><P><R><L><K><L><P><S><D><F><R><G><S><D><A><L><T><V><D><P><T><M><Y><K><C><L><W><K><P><D><L><F><F><A><N><E><K><S><A><N><F><H><D><V><T><Q><E><N><I><L><L><F><I><F><R><D><G><D><V><L><V><S><M><R><L><S><I><T><L><S><C><P><L><D><L><T><L><F><P><M><D><T><Q><R><C><K><M><Q><L><E><S><F><G><Y><T><T><D><D><L><R><F><I><W><Q><S><G><D><P><V><Q><L><E><K><I><A><L><P><Q><F><D><I><K><K><E><D><I><E><Y><G><N><C><T><K><Y><Y><K><G><T><G><Y><Y><T><C><V><E><V><I><F><T><L><R><R><Q><V><G><F><Y><M><M><G><V><Y><A><P><T><L><L><I><V><V><L><S><W><L><S><F><W><I><N><P><D><A><S><A><A><R><V><P><L><G><I><F><S><V><L><S><L><A><S><E><C><T><T><L><A><A><E><L><P><K><V><S><Y><V><K><A><L><D><V><W><L><I><A><C><L><L><F><G><F><A><S><L><V><E><Y><A><V><V><Q><V><M><L><N><N><P><K><R><V><E><A><E><K><A><R><I><A><K><A><E><Q><A><D><G><K><G><G><N><V><A><K><K><N><T><V><N><G><T><G><T><P><V><H><I><S><T><L><Q><V><G><E><T><R><C><K><K><V><C><T><S><K><S><D><L><R><S><N><D><F><S><I><V><G><S><L><P><R><D><F><E><L><S><N><Y><D><C><Y><G><K><P><I><E><V><N><N><G><L><G><K><S><Q><A><K><N><N><K><K><P><P><P><A><K><P><V><I><P><T><A><A><K><R><I><D><L><Y><A><R><A><L><F><P><F><C><F><L><F><F><N><V><I><Y><W><S><I><Y><L>
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine . Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 . Plays an important role in the down-regulation of neuronal excitability . Contributes to the generation of inhibitory postsynaptic currents .<BOP>
P48167