accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q96EB1 | ELP4_HUMAN | PAX6 neighbor gene protein | Homo | <M><A><A><V><A><T><C><G><S><V><A><A><S><T><G><S><A><V><A><T><A><S><K><S><N><V><T><S><F><Q><R><R><G><P><R><A><S><V><T><N><D><S><G><P><R><L><V><S><I><A><G><T><R><P><S><V><R><N><G><Q><L><L><V><S><T><G><L><P><A><L><D><Q><L><L><G><G><G><L><A><V><G><T><V><L><L><I><E><E><D><K><Y><N><I><Y><S><P><L><L><F><K><Y><F><L><A><E><G><I><V><N><G><H><T><L><L><V><A><S><A><K><E><D><P><A><N><I><L><Q><E><L><P><A><P><L><L><D><D><K><C><K><K><E><F><D><E><D><V><Y><N><H><K><T><P><E><S><N><I><K><M><K><I><A><W><R><Y><Q><L><L><P><K><M><E><I><G><P><V><S><S><S><R><F><G><H><Y><Y><D><A><S><K><R><M><P><Q><E><L><I><E><A><S><N><W><H><G><F><F><L><P><E><K><I><S><S><T><L><K><V><E><P><C><S><L><T><P><G><Y><T><K><L><L><Q><F><I><Q><N><I><I><Y><E><E><G><F><D><G><S><N><P><Q><K><K><Q><R><N><I><L><R><I><G><I><Q><N><L><G><S><P><L><W><G><D><D><I><C><C><A><E><N><G><G><N><S><H><S><L><T><K><F><L><Y><V><L><R><G><L><L><R><T><S><L><S><A><C><I><I><T><M><P><T><H><L><I><Q><N><K><A><I><I><A><R><V><T><T><L><S><D><V><V><V><G><L><E><S><F><I><G><S><E><R><E><T><N><P><L><Y><K><D><Y><H><G><L><I><H><I><R><Q><I><P><R><L><N><N><L><I><C><D><E><S><D><V><K><D><L><A><F><K><L><K><R><K><L><F><T><I><E><R><L><H><L><P><P><D><L><S><D><T><V><S><R><S><S><K><M><D><L><A><E><S><A><K><R><L><G><P><G><C><G><M><M><A><G><G><K><K><H><L><D><F> | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) . The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs .<BOP> | Q96EB1 |
Q16798 | MAON_HUMAN | Malic enzyme 3 | Homo | <M><G><A><A><L><G><T><G><T><R><L><A><P><W><P><G><R><A><C><G><A><L><P><R><W><T><P><T><A><P><A><Q><G><C><H><S><K><P><G><P><A><R><P><V><P><L><K><K><R><G><Y><D><V><T><R><N><P><H><L><N><K><G><M><A><F><T><L><E><E><R><L><Q><L><G><I><H><G><L><I><P><P><C><F><L><S><Q><D><V><Q><L><L><R><I><M><R><Y><Y><E><R><Q><Q><S><D><L><D><K><Y><I><I><L><M><T><L><Q><D><R><N><E><K><L><F><Y><R><V><L><T><S><D><V><E><K><F><M><P><I><V><Y><T><P><T><V><G><L><A><C><Q><H><Y><G><L><T><F><R><R><P><R><G><L><F><I><T><I><H><D><K><G><H><L><A><T><M><L><N><S><W><P><E><D><N><I><K><A><V><V><V><T><D><G><E><R><I><L><G><L><G><D><L><G><C><Y><G><M><G><I><P><V><G><K><L><A><L><Y><T><A><C><G><G><V><N><P><Q><Q><C><L><P><V><L><L><D><V><G><T><N><N><E><E><L><L><R><D><P><L><Y><I><G><L><K><H><Q><R><V><H><G><K><A><Y><D><D><L><L><D><E><F><M><Q><A><V><T><D><K><F><G><I><N><C><L><I><Q><F><E><D><F><A><N><A><N><A><F><R><L><L><N><K><Y><R><N><K><Y><C><M><F><N><D><D><I><Q><G><T><A><S><V><A><V><A><G><I><L><A><A><L><R><I><T><K><N><K><L><S><N><H><V><F><V><F><Q><G><A><G><E><A><A><M><G><I><A><H><L><L><V><M><A><L><E><K><E><G><V><P><K><A><E><A><T><R><K><I><W><M><V><D><S><K><G><L><I><V><K><G><R><S><H><L><N><H><E><K><E><M><F><A><Q><D><H><P><E><V><N><S><L><E><E><V><V><R><L><V><K><P><T><A><I><I><G><V><A><A><I><A><G><A><F><T><E><Q><I><L><R><D><M><A><S><F><H><E><R><P><I><I><F><A><L><S><N><P><T><S><K><A><E><C><T><A><E><K><C><Y><R><V><T><E><G><R><G><I><F><A><S><G><S><P><F><K><S><V><T><L><E><D><G><K><T><F><I><P><G><Q><G><N><N><A><Y><V><F><P><G><V><A><L><G><V><I><A><G><G><I><R><H><I><P><D><E><I><F><L><L><T><A><E><Q><I><A><Q><E><V><S><E><Q><H><L><S><Q><G><R><L><Y><P><P><L><S><T><I><R><D><V><S><L><R><I><A><I><K><V><L><D><Y><A><Y><K><H><N><L><A><S><Y><Y><P><E><P><K><D><K><E><A><F><V><R><S><L><V><Y><T><P><D><Y><D><S><F><T><L><D><S><Y><T><W><P><K><E><A><M><N><V><Q><T><V> | Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+) as a cofactor . Can also reverse the decarboxylation reaction, but only with significantly lower efficiency .<BOP> | Q16798 |
Q7Z5B4 | RIC3_HUMAN | Resistant to inhibitor of cholinesterase 3 | Homo | <M><A><Y><S><T><V><Q><R><V><A><L><A><S><G><L><V><L><A><L><S><L><L><L><P><K><A><F><L><S><R><G><K><R><Q><E><P><P><P><T><P><E><G><K><L><G><R><F><P><P><M><M><H><H><H><Q><A><P><S><D><G><Q><T><P><G><A><R><F><Q><R><S><H><L><A><E><A><F><A><K><A><K><G><S><G><G><G><A><G><G><G><G><S><G><R><G><L><M><G><Q><I><I><P><I><Y><G><F><G><I><F><L><Y><I><L><Y><I><L><F><K><L><S><K><G><K><T><T><A><E><D><G><K><C><Y><T><A><M><P><G><N><T><H><R><K><I><T><S><F><E><L><A><Q><L><Q><E><K><L><K><E><T><E><A><A><M><E><K><L><I><N><R><V><G><P><N><G><E><S><R><A><Q><T><V><T><S><D><Q><E><K><R><L><L><H><Q><L><R><E><I><T><R><V><M><K><E><G><K><F><I><D><R><F><S><P><E><K><E><A><E><E><A><P><Y><M><E><D><W><E><G><Y><P><E><E><T><Y><P><I><Y><D><L><S><D><C><I><K><R><R><Q><E><T><I><L><V><D><Y><P><D><P><K><E><L><S><A><E><E><I><A><E><R><M><G><M><I><E><E><E><E><S><D><H><L><G><W><E><S><L><P><T><D><P><R><A><Q><E><D><N><S><V><T><S><C><D><P><K><P><E><T><C><S><C><C><F><H><E><D><E><D><P><A><V><L><A><E><N><A><G><F><S><A><D><S><Y><P><E><Q><E><E><T><T><K><E><E><W><S><Q><D><F><K><D><E><G><L><G><I><S><T><D><K><A><Y><T><G><S><M><L><R><K><R><N><P><Q><G><L><E> | Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors . May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.<BOP> | Q7Z5B4 |
Q10471 | GALT2_HUMAN | Polypeptide N-acetylgalactosaminyltransferase 2 soluble form | Homo | <M><R><R><R><S><R><M><L><L><C><F><A><F><L><W><V><L><G><I><A><Y><Y><M><Y><S><G><G><G><S><A><L><A><G><G><A><G><G><G><A><G><R><K><E><D><W><N><E><I><D><P><I><K><K><K><D><L><H><H><S><N><G><E><E><K><A><Q><S><M><E><T><L><P><P><G><K><V><R><W><P><D><F><N><Q><E><A><Y><V><G><G><T><M><V><R><S><G><Q><D><P><Y><A><R><N><K><F><N><Q><V><E><S><D><K><L><R><M><D><R><A><I><P><D><T><R><H><D><Q><C><Q><R><K><Q><W><R><V><D><L><P><A><T><S><V><V><I><T><F><H><N><E><A><R><S><A><L><L><R><T><V><V><S><V><L><K><K><S><P><P><H><L><I><K><E><I><I><L><V><D><D><Y><S><N><D><P><E><D><G><A><L><L><G><K><I><E><K><V><R><V><L><R><N><D><R><R><E><G><L><M><R><S><R><V><R><G><A><D><A><A><Q><A><K><V><L><T><F><L><D><S><H><C><E><C><N><E><H><W><L><E><P><L><L><E><R><V><A><E><D><R><T><R><V><V><S><P><I><I><D><V><I><N><M><D><N><F><Q><Y><V><G><A><S><A><D><L><K><G><G><F><D><W><N><L><V><F><K><W><D><Y><M><T><P><E><Q><R><R><S><R><Q><G><N><P><V><A><P><I><K><T><P><M><I><A><G><G><L><F><V><M><D><K><F><Y><F><E><E><L><G><K><Y><D><M><M><M><D><V><W><G><G><E><N><L><E><I><S><F><R><V><W><Q><C><G><G><S><L><E><I><I><P><C><S><R><V><G><H><V><F><R><K><Q><H><P><Y><T><F><P><G><G><S><G><T><V><F><A><R><N><T><R><R><A><A><E><V><W><M><D><E><Y><K><N><F><Y><Y><A><A><V><P><S><A><R><N><V><P><Y><G><N><I><Q><S><R><L><E><L><R><K><K><L><S><C><K><P><F><K><W><Y><L><E><N><V><Y><P><E><L><R><V><P><D><H><Q><D><I><A><F><G><A><L><Q><Q><G><T><N><C><L><D><T><L><G><H><F><A><D><G><V><V><G><V><Y><E><C><H><N><A><G><G><N><Q><E><W><A><L><T><K><E><K><S><V><K><H><M><D><L><C><L><T><V><V><D><R><A><P><G><S><L><I><K><L><Q><G><C><R><E><N><D><S><R><Q><K><W><E><Q><I><E><G><N><S><K><L><R><H><V><G><S><N><L><C><L><D><S><R><T><A><K><S><G><G><L><S><V><E><V><C><G><P><A><L><S><Q><Q><W><K><F><T><L><N><L><Q><Q> | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism .<BOP> | Q10471 |
Q5SQ64 | LY66F_HUMAN | Lymphocyte antigen 6 complex locus protein G6f | Homo | <M><A><V><L><F><L><L><L><F><L><C><G><T><P><Q><A><A><D><N><M><Q><A><I><Y><V><A><L><G><E><A><V><E><L><P><C><P><S><P><P><T><L><H><G><D><E><H><L><S><W><F><C><S><P><A><A><G><S><F><T><T><L><V><A><Q><V><Q><V><G><R><P><A><P><D><P><G><K><P><G><R><E><S><R><L><R><L><L><G><N><Y><S><L><W><L><E><G><S><K><E><E><D><A><G><R><Y><W><C><A><V><L><G><Q><H><H><N><Y><Q><N><W><R><V><Y><D><V><L><V><L><K><G><S><Q><L><S><A><R><A><A><D><G><S><P><C><N><V><L><L><C><S><V><V><P><S><R><R><M><D><S><V><T><W><Q><E><G><K><G><P><V><R><G><R><V><Q><S><F><W><G><S><E><A><A><L><L><L><V><C><P><G><E><G><L><S><E><P><R><S><R><R><P><R><I><I><R><C><L><M><T><H><N><K><G><V><S><F><S><L><A><A><S><I><D><A><S><P><A><L><C><A><P><S><T><G><W><D><M><P><W><I><L><M><L><L><L><T><M><G><Q><G><V><V><I><L><A><L><S><I><V><L><W><R><Q><R><V><R><G><A><P><G><R><D><A><S><I><P><Q><F><K><P><E><I><Q><V><Y><E><N><I><H><L><A><R><L><G><P><P><A><H><K><P><R> | May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.<BOP> | Q5SQ64 |
Q96IK0 | TM101_HUMAN | Putative NF-kappa-B-activating protein 130 | Homo | <M><A><S><K><I><G><S><R><R><W><M><L><Q><L><I><M><Q><L><G><S><V><L><L><T><R><C><P><F><W><G><C><F><S><Q><L><M><L><Y><A><E><R><A><E><A><R><R><K><P><D><I><P><V><P><Y><L><Y><F><D><M><G><A><A><V><L><C><A><S><F><M><S><F><G><V><K><R><R><W><F><A><L><G><A><A><L><Q><L><A><I><S><T><Y><A><A><Y><I><G><G><Y><V><H><Y><G><D><W><L><K><V><R><M><Y><S><R><T><V><A><I><I><G><G><F><L><V><L><A><S><G><A><G><E><L><Y><R><R><K><P><R><S><R><S><L><Q><S><T><G><Q><V><F><L><G><I><Y><L><I><C><V><A><Y><S><L><Q><H><S><K><E><D><R><L><A><Y><L><N><H><L><P><G><G><E><L><M><I><Q><L><F><F><V><L><Y><G><I><L><A><L><A><F><L><S><G><Y><Y><V><T><L><A><A><Q><I><L><A><V><L><L><P><P><V><M><L><L><I><D><G><N><V><A><Y><W><H><N><T><R><R><V><E><F><W><N><Q><M><K><L><L><G><E><S><V><G><I><F><G><T><A><V><I><L><A><T><D><G> | May activate NF-kappa-B signaling pathways.<BOP> | Q96IK0 |
Q9NVM9 | INT13_HUMAN | Sarcoma antigen NY-SAR-95 | Homo | <M><K><I><F><S><E><S><H><K><T><V><F><V><V><D><H><C><P><Y><M><A><E><S><C><R><Q><H><V><E><F><D><M><L><V><K><N><R><T><Q><G><I><I><P><L><A><P><I><S><K><S><L><W><T><C><S><V><E><S><S><M><E><Y><C><R><I><M><Y><D><I><F><P><F><K><K><L><V><N><F><I><V><S><D><S><G><A><H><V><L><N><S><W><T><Q><E><D><Q><N><L><Q><E><L><M><A><A><L><A><A><V><G><P><P><N><P><R><A><D><P><E><C><C><S><I><L><H><G><L><V><A><A><V><E><T><L><C><K><I><T><E><Y><Q><H><E><A><R><T><L><L><M><E><N><A><E><R><V><G><N><R><G><R><I><I><C><I><T><N><A><K><S><D><S><H><V><R><M><L><E><D><C><V><Q><E><T><I><H><E><H><N><K><L><A><A><N><S><D><H><L><M><Q><I><Q><K><C><E><L><V><L><I><H><T><Y><P><V><G><E><D><S><L><V><S><D><R><S><K><K><E><L><S><P><V><L><T><S><E><V><H><S><V><R><A><G><R><H><L><A><T><K><L><N><I><L><V><Q><Q><H><F><D><L><A><S><T><T><I><T><N><I><P><M><K><E><E><Q><H><A><N><T><S><A><N><Y><D><V><E><L><L><H><H><K><D><A><H><V><D><F><L><K><S><G><D><S><H><L><G><G><G><S><R><E><G><S><F><K><E><T><I><T><L><K><W><C><T><P><R><T><N><N><I><E><L><H><Y><C><T><G><A><Y><R><I><S><P><V><D><V><N><S><R><P><S><S><C><L><T><N><F><L><L><N><G><R><S><V><L><L><E><Q><P><R><K><S><G><S><K><V><I><S><H><M><L><S><S><H><G><G><E><I><F><L><H><V><L><S><S><S><R><S><I><L><E><D><P><P><S><I><S><E><G><C><G><G><R><V><T><D><Y><R><I><T><D><F><G><E><F><M><R><E><N><R><L><T><P><F><L><D><P><R><Y><K><I><D><G><S><L><E><V><P><L><E><R><A><K><D><Q><L><E><K><H><T><R><Y><W><P><M><I><I><S><Q><T><T><I><F><N><M><Q><A><V><V><P><L><A><S><V><I><V><K><E><S><L><T><E><E><D><V><L><N><C><Q><K><T><I><Y><N><L><V><D><M><E><R><K><N><D><P><L><P><I><S><T><V><G><T><R><G><K><G><P><K><R><D><E><Q><Y><R><I><M><W><N><E><L><E><T><L><V><R><A><H><I><N><N><S><E><K><H><Q><R><V><L><E><C><L><M><A><C><R><S><K><P><P><E><E><E><E><R><K><K><R><G><R><K><R><E><D><K><E><D><K><S><E><K><A><V><K><D><Y><E><Q><E><K><S><W><Q><D><S><E><R><L><K><G><I><L><E><R><G><K><E><E><L><A><E><A><E><I><I><K><D><S><P><D><S><P><E><P><P><N><K><K><P><L><V><E><M><D><E><T><P><Q><V><E><K><S><K><G><P><V><S><L><L><S><L><W><S><N><R><I><N><T><A><N><S><R><K><H><Q><E><F><A><G><R><L><N><S><V><N><N><R><A><E><L><Y><Q><H><L><K><E><E><N><G><M><E><T><T><E><N><G><K><A><S><R><Q> | Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing .<BOP> | Q9NVM9 |
Q86VQ0 | LCA5_HUMAN | Leber congenital amaurosis 5 protein | Homo | <M><G><E><R><A><G><S><P><G><T><D><Q><E><R><K><A><G><K><H><H><Y><S><Y><L><S><D><F><E><T><P><Q><S><S><G><R><S><S><L><V><S><S><S><P><A><S><V><R><R><K><N><P><K><R><Q><T><S><D><G><Q><V><H><H><Q><A><P><R><K><P><S><P><K><G><L><P><N><R><K><G><V><R><V><G><F><R><S><Q><S><L><N><R><E><P><L><R><K><D><T><D><L><V><T><K><R><I><L><S><A><R><L><L><K><I><N><E><L><Q><N><E><V><S><E><L><Q><V><K><L><A><E><L><L><K><E><N><K><S><L><K><R><L><Q><Y><R><Q><E><K><A><L><N><K><F><E><D><A><E><N><E><I><S><Q><L><I><F><R><H><N><N><E><I><T><A><L><K><E><R><L><R><K><S><Q><E><K><E><R><A><T><E><K><R><V><K><D><T><E><S><E><L><F><R><T><K><F><S><L><Q><K><L><K><E><I><S><E><A><R><H><L><P><E><R><D><D><L><A><K><K><L><V><S><A><E><L><K><L><D><D><T><E><R><R><I><K><E><L><S><K><N><L><E><L><S><T><N><S><F><Q><R><Q><L><L><A><E><R><K><R><A><Y><E><A><H><D><E><N><K><V><L><Q><K><E><V><Q><R><L><Y><H><K><L><K><E><K><E><R><E><L><D><I><K><N><I><Y><S><N><R><L><P><K><S><S><P><N><K><E><K><E><L><A><L><R><K><N><A><A><C><Q><S><D><F><A><D><L><C><T><K><G><V><Q><T><M><E><D><F><K><P><E><E><Y><P><L><T><P><E><T><I><M><C><Y><E><N><K><W><E><E><P><G><H><L><T><L><D><L><Q><S><Q><K><Q><D><R><H><G><E><A><G><I><L><N><P><I><M><E><R><E><E><K><F><V><T><D><E><E><L><H><V><V><K><Q><E><V><E><K><L><E><D><E><W><E><R><E><E><L><D><K><K><Q><K><E><K><A><S><L><L><E><R><E><E><K><P><E><W><E><T><G><R><Y><Q><L><G><M><Y><P><I><Q><N><M><D><K><L><Q><G><E><E><E><E><R><L><K><R><E><M><L><L><A><K><L><N><E><I><D><R><E><L><Q><D><S><R><N><L><K><Y><P><V><L><P><L><L><P><D><F><E><S><K><L><H><S><P><E><R><S><P><K><T><Y><R><F><S><E><S><S><E><R><L><F><N><G><H><H><L><Q><D><I><S><F><S><T><P><K><G><E><G><Q><N><S><G><N><V><R><S><P><A><S><P><N><E><F><A><F><G><S><Y><V><P><S><F><A><K><T><S><E><R><S><N><P><F><S><Q><K><S><S><F><L><D><F><Q><R><N><S><M><E><K><L><S><K><D><G><V><D><L><I><T><R><K><E><K><K><A><N><L><M><E><Q><L><F><G><A><S><G><S><S><T><I><S><S><K><S><S><D><P><N><S><V><A><S><S><K><G><D><I><D><P><L><N><F><L><P><G><N><K><G><S><R><D><Q><E><H><D><E><D><E><G><F><F><L><S><E><G><R><S><F><N><P><N><R><H><R><L><K><H><A><D><D><K><P><A><V><K><A><A><D><S><V><E><D><E><I><E><E><V><A><L><R> | Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.<BOP> | Q86VQ0 |
Q9NNX9 | VCX3_HUMAN | Variably charged protein X-A | Homo | <M><S><P><K><P><R><A><S><G><P><P><A><K><A><T><E><A><G><K><R><K><S><S><S><Q><P><S><P><S><D><P><K><K><K><T><T><K><V><A><K><K><G><K><A><V><R><R><G><R><R><G><K><K><G><A><A><T><K><M><A><A><V><T><A><P><E><A><E><S><G><P><A><A><P><G><P><S><D><Q><P><S><Q><E><L><P><Q><H><E><L><P><P><E><E><P><V><S><E><G><T><Q><H><D><P><L><S><Q><E><S><E><L><E><E><P><L><S><Q><E><S><E><V><E><E><P><L><S><Q><E><S><Q><V><E><E><P><L><S><Q><E><S><E><V><E><E><P><L><S><Q><E><S><Q><V><E><E><P><L><S><Q><E><S><E><V><E><E><P><L><S><Q><E><S><Q><V><E><E><P><L><S><Q><E><S><E><M><E><E><L><P><S><V> | May mediate a process in spermatogenesis or may play a role in sex ratio distortion.<BOP> | Q9NNX9 |
Q96PJ5 | FCRL4_HUMAN | Immune receptor translocation-associated protein 1 | Homo | <M><L><L><W><A><S><L><L><A><F><A><P><V><C><G><Q><S><A><A><A><H><K><P><V><I><S><V><H><P><P><W><T><T><F><F><K><G><E><R><V><T><L><T><C><N><G><F><Q><F><Y><A><T><E><K><T><T><W><Y><H><R><H><Y><W><G><E><K><L><T><L><T><P><G><N><T><L><E><V><R><E><S><G><L><Y><R><C><Q><A><R><G><S><P><R><S><N><P><V><R><L><L><F><S><S><D><S><L><I><L><Q><A><P><Y><S><V><F><E><G><D><T><L><V><L><R><C><H><R><R><R><K><E><K><L><T><A><V><K><Y><T><W><N><G><N><I><L><S><I><S><N><K><S><W><D><L><L><I><P><Q><A><S><S><N><N><N><G><N><Y><R><C><I><G><Y><G><D><E><N><D><V><F><R><S><N><F><K><I><I><K><I><Q><E><L><F><P><H><P><E><L><K><A><T><D><S><Q><P><T><E><G><N><S><V><N><L><S><C><E><T><Q><L><P><P><E><R><S><D><T><P><L><H><F><N><F><F><R><D><G><E><V><I><L><S><D><W><S><T><Y><P><E><L><Q><L><P><T><V><W><R><E><N><S><G><S><Y><W><C><G><A><E><T><V><R><G><N><I><H><K><H><S><P><S><L><Q><I><H><V><Q><R><I><P><V><S><G><V><L><L><E><T><Q><P><S><G><G><Q><A><V><E><G><E><M><L><V><L><V><C><S><V><A><E><G><T><G><D><T><T><F><S><W><H><R><E><D><M><Q><E><S><L><G><R><K><T><Q><R><S><L><R><A><E><L><E><L><P><A><I><R><Q><S><H><A><G><G><Y><Y><C><T><A><D><N><S><Y><G><P><V><Q><S><M><V><L><N><V><T><V><R><E><T><P><G><N><R><D><G><L><V><A><A><G><A><T><G><G><L><L><S><A><L><L><L><A><V><A><L><L><F><H><C><W><R><R><R><K><S><G><V><G><F><L><G><D><E><T><R><L><P><P><A><P><G><P><G><E><S><S><H><S><I><C><P><A><Q><V><E><L><Q><S><L><Y><V><D><V><H><P><K><K><G><D><L><V><Y><S><E><I><Q><T><T><Q><L><G><E><E><E><E><A><N><T><S><R><T><L><L><E><D><K><D><V><S><V><V><Y><S><E><V><K><T><Q><H><P><D><N><S><A><G><K><I><S><S><K><D><E><E><S> | May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.<BOP> | Q96PJ5 |
Q99848 | EBP2_HUMAN | Nucleolar protein p40 | Homo | <M><D><T><P><P><L><S><D><S><E><S><E><S><D><E><S><L><V><T><D><R><E><L><Q><D><A><F><S><R><G><L><L><K><P><G><L><N><V><V><L><E><G><P><K><K><A><V><N><D><V><N><G><L><K><Q><C><L><A><E><F><K><R><D><L><E><W><V><E><R><L><D><V><T><L><G><P><V><P><E><I><G><G><S><E><A><P><A><P><Q><N><K><D><Q><K><A><V><D><P><E><D><D><F><Q><R><E><M><S><F><Y><R><Q><A><Q><A><A><V><L><A><V><L><P><R><L><H><Q><L><K><V><P><T><K><R><P><T><D><Y><F><A><E><M><A><K><S><D><L><Q><M><Q><K><I><R><Q><K><L><Q><T><K><Q><A><A><M><E><R><S><E><K><A><K><Q><L><R><A><L><R><K><Y><G><K><K><V><Q><T><E><V><L><Q><K><R><Q><Q><E><K><A><H><M><M><N><A><I><K><K><Y><Q><K><G><F><S><D><K><L><D><F><L><E><G><D><Q><K><P><L><A><Q><R><K><K><A><G><A><K><G><Q><Q><M><R><K><G><P><S><A><K><R><R><Y><K><N><Q><K><F><G><F><G><G><K><K><K><G><S><K><W><N><T><R><E><S><Y><D><D><V><S><S><F><R><A><K><T><A><H><G><R><G><L><K><R><P><G><K><K><G><S><N><K><R><P><G><K><R><T><R><E><K><M><K><N><R><T><H> | Required for the processing of the 27S pre-rRNA.<BOP> | Q99848 |
Q00796 | DHSO_HUMAN | Xylitol dehydrogenase | Homo | <M><A><A><A><A><K><P><N><N><L><S><L><V><V><H><G><P><G><D><L><R><L><E><N><Y><P><I><P><E><P><G><P><N><E><V><L><L><R><M><H><S><V><G><I><C><G><S><D><V><H><Y><W><E><Y><G><R><I><G><N><F><I><V><K><K><P><M><V><L><G><H><E><A><S><G><T><V><E><K><V><G><S><S><V><K><H><L><K><P><G><D><R><V><A><I><E><P><G><A><P><R><E><N><D><E><F><C><K><M><G><R><Y><N><L><S><P><S><I><F><F><C><A><T><P><P><D><D><G><N><L><C><R><F><Y><K><H><N><A><A><F><C><Y><K><L><P><D><N><V><T><F><E><E><G><A><L><I><E><P><L><S><V><G><I><H><A><C><R><R><G><G><V><T><L><G><H><K><V><L><V><C><G><A><G><P><I><G><M><V><T><L><L><V><A><K><A><M><G><A><A><Q><V><V><V><T><D><L><S><A><T><R><L><S><K><A><K><E><I><G><A><D><L><V><L><Q><I><S><K><E><S><P><Q><E><I><A><R><K><V><E><G><Q><L><G><C><K><P><E><V><T><I><E><C><T><G><A><E><A><S><I><Q><A><G><I><Y><A><T><R><S><G><G><N><L><V><L><V><G><L><G><S><E><M><T><T><V><P><L><L><H><A><A><I><R><E><V><D><I><K><G><V><F><R><Y><C><N><T><W><P><V><A><I><S><M><L><A><S><K><S><V><N><V><K><P><L><V><T><H><R><F><P><L><E><K><A><L><E><A><F><E><T><F><K><K><G><L><G><L><K><I><M><L><K><C><D><P><S><D><Q><N><P> | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively . Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia . May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility . May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other | Q00796 |
Q05925 | HME1_HUMAN | Homeobox protein engrailed-1 | Homo | <M><E><E><Q><Q><P><E><P><K><S><Q><R><D><S><A><L><G><A><A><A><A><A><T><P><G><G><L><S><L><S><L><S><P><G><A><S><G><S><S><G><S><G><S><D><G><D><S><V><P><V><S><P><Q><P><A><P><P><S><P><P><A><A><P><C><L><P><P><L><A><H><H><P><H><L><P><P><H><P><P><P><P><P><P><Q><H><L><A><A><P><A><H><Q><P><Q><P><A><A><Q><L><H><R><T><T><N><F><F><I><D><N><I><L><R><P><D><F><G><C><K><K><E><Q><P><P><P><Q><L><L><V><A><A><A><A><R><G><G><A><G><G><G><G><R><V><E><R><D><R><G><Q><T><A><A><G><R><D><P><V><H><P><L><G><T><R><A><P><G><A><A><S><L><L><C><A><P><D><A><N><C><G><P><P><D><G><S><Q><P><A><A><A><G><A><G><A><S><K><A><G><N><P><A><A><A><A><A><A><A><A><A><A><V><A><A><A><A><A><A><A><A><A><K><P><S><D><T><G><G><G><G><S><G><G><G><A><G><S><P><G><A><Q><G><T><K><Y><P><E><H><G><N><P><A><I><L><L><M><G><S><A><N><G><G><P><V><V><K><T><D><S><Q><Q><P><L><V><W><P><A><W><V><Y><C><T><R><Y><S><D><R><P><S><S><G><P><R><T><R><K><L><K><K><K><K><N><E><K><E><D><K><R><P><R><T><A><F><T><A><E><Q><L><Q><R><L><K><A><E><F><Q><A><N><R><Y><I><T><E><Q><R><R><Q><T><L><A><Q><E><L><S><L><N><E><S><Q><I><K><I><W><F><Q><N><K><R><A><K><I><K><K><A><T><G><I><K><N><G><L><A><L><H><L><M><A><Q><G><L><Y><N><H><S><T><T><T><V><Q><D><K><D><E><S><E> | Required for proper formation of the apical ectodermal ridge and correct dorsal-ventral patterning in the limb.<BOP> | Q05925 |
K7EJ46 | SIM22_HUMAN | Cancer-associated small integral membrane open reading frame 1 | Homo | <M><A><V><S><T><E><E><L><E><A><T><V><Q><E><V><L><G><R><L><K><S><H><Q><F><F><Q><S><T><W><D><T><V><A><F><I><V><F><L><T><F><M><G><T><V><L><L><L><L><L><L><V><V><A><H><C><C><C><C><S><S><P><G><P><R><R><E><S><P><R><K><E><R><P><K><G><V><D><N><L><A><L><E><P> | May modulate lipid droplet formation throught interaction with SQLE.<BOP> | K7EJ46 |
Q8NHB8 | OR5K2_HUMAN | Olfactory receptor OR3-9 | Homo | <M><V><E><E><N><H><T><M><K><N><E><F><I><L><T><G><F><T><D><H><P><E><L><K><T><L><L><F><V><V><F><F><A><I><Y><L><I><T><V><V><G><N><I><S><L><V><A><L><I><F><T><H><C><R><L><H><T><P><M><Y><I><F><L><G><N><L><A><L><V><D><S><C><C><A><C><A><I><T><P><K><M><L><E><N><F><F><S><E><G><K><R><I><S><L><Y><E><C><A><V><Q><F><Y><F><L><C><T><V><E><T><A><D><C><F><L><L><A><A><V><A><Y><D><R><Y><V><A><I><C><N><P><L><Q><Y><H><I><M><M><S><K><K><L><C><I><Q><M><T><T><G><A><F><I><A><G><N><L><H><S><M><I><H><V><G><L><V><F><R><L><V><F><C><G><L><N><H><I><N><H><F><Y><C><D><T><L><P><L><Y><R><L><S><C><V><D><P><F><I><N><E><L><V><L><F><I><F><S><G><S><V><Q><V><F><T><I><G><S><V><L><I><S><Y><L><Y><I><L><L><T><I><F><R><M><K><S><K><E><G><R><A><K><A><F><S><T><C><A><S><H><F><S><S><V><S><L><F><Y><G><S><I><F><F><L><Y><I><R><P><N><L><L><E><E><G><G><N><D><I><P><A><A><I><L><F><T><I><V><V><P><L><L><N><P><F><I><Y><S><L><R><N><K><E><V><I><S><V><L><R><K><I><L><L><K><I><K><S><Q><G><S><V><N><K> | Odorant receptor.<BOP> | Q8NHB8 |
Q13094 | LCP2_HUMAN | SLP-76 tyrosine phosphoprotein | Homo | <M><A><L><R><N><V><P><F><R><S><E><V><L><G><W><D><P><D><S><L><A><D><Y><F><K><K><L><N><Y><K><D><C><E><K><A><V><K><K><Y><H><I><D><G><A><R><F><L><N><L><T><E><N><D><I><Q><K><F><P><K><L><R><V><P><I><L><S><K><L><S><Q><E><I><N><K><N><E><E><R><R><S><I><F><T><R><K><P><Q><V><P><R><F><P><E><E><T><E><S><H><E><E><D><N><G><G><W><S><S><F><E><E><D><D><Y><E><S><P><N><D><D><Q><D><G><E><D><D><G><D><Y><E><S><P><N><E><E><E><E><A><P><V><E><D><D><A><D><Y><E><P><P><P><S><N><D><E><E><A><L><Q><N><S><I><L><P><A><K><P><F><P><N><S><N><S><M><Y><I><D><R><P><P><S><G><K><T><P><Q><Q><P><P><V><P><P><Q><R><P><M><A><A><L><P><P><P><P><A><G><R><N><H><S><P><L><P><P><P><Q><T><N><H><E><E><P><S><R><S><R><N><H><K><T><A><K><L><P><A><P><S><I><D><R><S><T><K><P><P><L><D><R><S><L><A><P><F><D><R><E><P><F><T><L><G><K><K><P><P><F><S><D><K><P><S><I><P><A><G><R><S><L><G><E><H><L><P><K><I><Q><K><P><P><L><P><P><T><T><E><R><H><E><R><S><S><P><L><P><G><K><K><P><P><V><P><K><H><G><W><G><P><D><R><R><E><N><D><E><D><D><V><H><Q><R><P><L><P><Q><P><A><L><L><P><M><S><S><N><T><F><P><S><R><S><T><K><P><S><P><M><N><P><L><P><S><S><H><M><P><G><A><F><S><E><S><N><S><S><F><P><Q><S><A><S><L><P><P><Y><F><S><Q><G><P><S><N><R><P><P><I><R><A><E><G><R><N><F><P><L><P><L><P><N><K><P><R><P><P><S><P><A><E><E><E><N><S><L><N><E><E><W><Y><V><S><Y><I><T><R><P><E><A><E><A><A><L><R><K><I><N><Q><D><G><T><F><L><V><R><D><S><S><K><K><T><T><T><N><P><Y><V><L><M><V><L><Y><K><D><K><V><Y><N><I><Q><I><R><Y><Q><K><E><S><Q><V><Y><L><L><G><T><G><L><R><G><K><E><D><F><L><S><V><S><D><I><I><D><Y><F><R><K><M><P><L><L><L><I><D><G><K><N><R><G><S><R><Y><Q><C><T><L><T><H><A><A><G><Y><P> | Involved in T-cell antigen receptor mediated signaling.<BOP> | Q13094 |
Q9BUP3 | HTAI2_HUMAN | HIV-1 TAT-interactive protein 2 | Homo | <M><A><E><T><E><A><L><S><K><L><R><E><D><F><R><M><Q><N><K><S><V><F><I><L><G><A><S><G><E><T><G><R><V><L><L><K><E><I><L><E><Q><G><L><F><S><K><V><T><L><I><G><R><R><K><L><T><F><D><E><E><A><Y><K><N><V><N><Q><E><V><V><D><F><E><K><L><D><D><Y><A><S><A><F><Q><G><H><D><V><G><F><C><C><L><G><T><T><R><G><K><A><G><A><E><G><F><V><R><V><D><R><D><Y><V><L><K><S><A><E><L><A><K><A><G><G><C><K><H><F><N><L><L><S><S><K><G><A><D><K><S><S><N><F><L><Y><L><Q><V><K><G><E><V><E><A><K><V><E><E><L><K><F><D><R><Y><S><V><F><R><P><G><V><L><L><C><D><R><Q><E><S><R><P><G><E><W><L><V><R><K><F><F><G><S><L><P><D><S><W><A><S><G><H><S><V><P><V><V><T><V><V><R><A><M><L><N><N><V><V><R><P><R><D><K><Q><M><E><L><L><E><N><K><A><I><H><D><L><G><K><A><H><G><S><L><K><P> | Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.<BOP> | Q9BUP3 |
Q9H341 | O51M1_HUMAN | Olfactory receptor OR11-40 | Homo | <M><S><V><Q><Y><S><L><S><P><Q><F><M><L><L><S><N><I><T><Q><F><S><P><I><F><Y><L><T><S><F><P><G><L><E><G><I><K><H><W><I><F><I><P><F><F><F><M><Y><M><V><A><I><S><G><N><C><F><I><L><I><I><I><K><T><N><P><R><L><H><T><P><M><Y><Y><L><L><S><L><L><A><L><T><D><L><G><L><C><V><S><T><L><P><T><T><M><G><I><F><W><F><N><S><H><S><I><Y><F><G><A><C><Q><I><Q><M><F><C><I><H><S><F><S><F><M><E><S><S><V><L><L><M><M><S><F><D><R><L><V><A><I><C><H><P><L><R><Y><S><V><I><I><T><G><Q><Q><V><V><R><A><G><L><I><V><I><F><R><G><P><V><A><T><I><P><I><V><L><L><L><K><A><F><P><Y><C><G><S><V><V><L><S><H><S><F><C><L><H><Q><E><V><I><Q><L><A><C><T><D><I><T><F><N><N><L><Y><G><L><M><V><V><V><F><T><V><M><L><D><L><V><L><I><A><L><S><Y><G><L><I><L><H><T><V><A><G><L><A><S><Q><E><E><Q><R><R><A><F><Q><T><C><T><A><P><L><C><A><V><L><V><F><F><V><P><M><M><G><L><S><L><V><H><R><F><G><K><H><A><P><P><A><I><H><L><L><M><A><N><V><Y><L><F><V><P><P><M><L><N><P><I><I><Y><S><I><K><T><K><E><I><H><R><A><I><I><K><F><L><G><L><K><K><A><S><K> | Odorant receptor.<BOP> | Q9H341 |
Q9BVK8 | TM147_HUMAN | Protein NIFIE 14 | Homo | <M><T><L><F><H><F><G><N><C><F><A><L><A><Y><F><P><Y><F><I><T><Y><K><C><S><G><L><S><E><Y><N><A><F><W><K><C><V><Q><A><G><V><T><Y><L><F><V><Q><L><C><K><M><L><F><L><A><T><F><F><P><T><W><E><G><G><I><Y><D><F><I><G><E><F><M><K><A><S><V><D><V><A><D><L><I><G><L><N><L><V><M><S><R><N><A><G><K><G><E><Y><K><I><M><V><A><A><L><G><W><A><T><A><E><L><I><M><S><R><C><I><P><L><W><V><G><A><R><G><I><E><F><D><W><K><Y><I><Q><M><S><I><D><S><N><I><S><L><V><H><Y><I><V><A><S><A><Q><V><W><M><I><T><R><Y><D><L><Y><H><T><F><R><P><A><V><L><L><L><M><F><L><S><V><Y><K><A><F><V><M><E><T><F><V><H><L><C><S><L><G><S><W><A><A><L><L><A><R><A><V><V><T><G><L><L><A><L><S><T><L><A><L><Y><V><A><V><V><N><V><H><S> | Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis . Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity . Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity .<BOP> | Q9BVK8 |
Q6ZMJ4 | IL34_HUMAN | Interleukin-34 | Homo | <M><P><R><G><F><T><W><L><R><Y><L><G><I><F><L><G><V><A><L><G><N><E><P><L><E><M><W><P><L><T><Q><N><E><E><C><T><V><T><G><F><L><R><D><K><L><Q><Y><R><S><R><L><Q><Y><M><K><H><Y><F><P><I><N><Y><K><I><S><V><P><Y><E><G><V><F><R><I><A><N><V><T><R><L><Q><R><A><Q><V><S><E><R><E><L><R><Y><L><W><V><L><V><S><L><S><A><T><E><S><V><Q><D><V><L><L><E><G><H><P><S><W><K><Y><L><Q><E><V><E><T><L><L><L><N><V><Q><Q><G><L><T><D><V><E><V><S><P><K><V><E><S><V><L><S><L><L><N><A><P><G><P><N><L><K><L><V><R><P><K><A><L><L><D><N><C><F><R><V><M><E><L><L><Y><C><S><C><C><K><Q><S><S><V><L><N><W><Q><D><C><E><V><P><S><P><Q><S><C><S><P><E><P><S><L><Q><Y><A><A><T><Q><L><Y><P><P><P><P><W><S><P><S><S><P><P><H><S><T><G><S><V><R><P><V><R><A><Q><G><E><G><L><L><P> | Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.<BOP> | Q6ZMJ4 |
O15258 | RER1_HUMAN | Protein RER1 | Homo | <M><S><E><G><D><S><V><G><E><S><V><H><G><K><P><S><V><V><Y><R><F><F><T><R><L><G><Q><I><Y><Q><S><W><L><D><K><S><T><P><Y><T><A><V><R><W><V><V><T><L><G><L><S><F><V><Y><M><I><R><V><Y><L><L><Q><G><W><Y><I><V><T><Y><A><L><G><I><Y><H><L><N><L><F><I><A><F><L><S><P><K><V><D><P><S><L><M><E><D><S><D><D><G><P><S><L><P><T><K><Q><N><E><E><F><R><P><F><I><R><R><L><P><E><F><K><F><W><H><A><A><T><K><G><I><L><V><A><M><V><C><T><F><F><D><A><F><N><V><P><V><F><W><P><I><L><V><M><Y><F><I><M><L><F><C><I><T><M><K><R><Q><I><K><H><M><I><K><Y><R><Y><I><P><F><T><H><G><K><R><R><Y><R><G><K><E><D><A><G><K><A><F><A><S> | Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.<BOP> | O15258 |
P61960 | UFM1_HUMAN | Ubiquitin-fold modifier 1 | Homo | <M><S><K><V><S><F><K><I><T><L><T><S><D><P><R><L><P><Y><K><V><L><S><V><P><E><S><T><P><F><T><A><V><L><K><F><A><A><E><E><F><K><V><P><A><A><T><S><A><I><I><T><N><D><G><I><G><I><N><P><A><Q><T><A><G><N><V><F><L><K><H><G><S><E><L><R><I><I><P><R><D><R><V><G><S><C> | Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer . The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 . Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress . Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription .<BOP> | P61960 |
Q13072 | BAGE1_HUMAN | Cancer/testis antigen 2.1 | Homo | <M><A><A><R><A><V><F><L><A><L><S><A><Q><L><L><Q><A><R><L><M><K><E><E><S><P><V><V><S><W><R><L><E><P><E><D><G><T><A><L><C><F><I><F> | Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.<BOP> | Q13072 |
O60218 | AK1BA_HUMAN | Small intestine reductase | Homo | <M><A><T><F><V><E><L><S><T><K><A><K><M><P><I><V><G><L><G><T><W><K><S><P><L><G><K><V><K><E><A><V><K><V><A><I><D><A><G><Y><R><H><I><D><C><A><Y><V><Y><Q><N><E><H><E><V><G><E><A><I><Q><E><K><I><Q><E><K><A><V><K><R><E><D><L><F><I><V><S><K><L><W><P><T><F><F><E><R><P><L><V><R><K><A><F><E><K><T><L><K><D><L><K><L><S><Y><L><D><V><Y><L><I><H><W><P><Q><G><F><K><S><G><D><D><L><F><P><K><D><D><K><G><N><A><I><G><G><K><A><T><F><L><D><A><W><E><A><M><E><E><L><V><D><E><G><L><V><K><A><L><G><V><S><N><F><S><H><F><Q><I><E><K><L><L><N><K><P><G><L><K><Y><K><P><V><T><N><Q><V><E><C><H><P><Y><L><T><Q><E><K><L><I><Q><Y><C><H><S><K><G><I><T><V><T><A><Y><S><P><L><G><S><P><D><R><P><W><A><K><P><E><D><P><S><L><L><E><D><P><K><I><K><E><I><A><A><K><H><K><K><T><A><A><Q><V><L><I><R><F><H><I><Q><R><N><V><I><V><I><P><K><S><V><T><P><A><R><I><V><E><N><I><Q><V><F><D><F><K><L><S><D><E><E><M><A><T><I><L><S><F><N><R><N><W><R><A><C><N><V><L><Q><S><S><H><L><E><D><Y><P><F><N><A><E><Y> | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols . Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal . Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) . Displays no reductase activity towards glucose .<BOP> | O60218 |
Q9BY78 | RNF26_HUMAN | RING finger protein 26 | Homo | <M><E><A><V><Y><L><V><V><N><G><L><G><L><V><L><D><V><L><T><L><V><L><D><L><N><F><L><L><V><S><S><L><L><A><S><L><A><W><L><L><A><F><V><Y><N><L><P><H><T><V><L><T><S><L><L><H><L><G><R><G><V><L><L><S><L><L><A><L><I><E><A><V><V><R><F><T><C><G><G><L><Q><A><L><C><T><L><L><Y><S><C><C><S><G><L><E><S><L><K><L><L><G><H><L><A><S><H><G><A><L><R><S><R><E><I><L><H><R><G><V><L><N><V><V><S><S><G><H><A><L><L><R><Q><A><C><D><I><C><A><I><A><M><S><L><V><A><Y><V><I><N><S><L><V><N><I><C><L><I><G><T><Q><N><L><F><S><L><V><L><A><L><W><D><A><V><T><G><P><L><W><R><M><T><D><V><V><A><A><F><L><A><H><I><S><S><S><A><V><A><M><A><I><L><L><W><T><P><C><Q><L><A><L><E><L><L><A><S><A><A><R><L><L><A><S><F><V><L><V><N><L><T><G><L><V><L><L><A><C><V><L><A><V><T><V><T><V><L><H><P><D><F><T><L><R><L><A><T><Q><A><L><S><Q><L><H><A><R><P><S><Y><H><R><L><R><E><D><V><M><R><L><S><R><L><A><L><G><S><E><A><W><R><R><V><W><S><R><S><L><Q><L><A><S><W><P><N><R><G><G><A><P><G><A><P><Q><G><D><P><M><R><V><F><S><V><R><T><R><R><Q><D><T><L><P><E><A><G><R><R><S><E><A><E><E><E><E><A><R><T><I><R><V><T><P><V><R><G><R><E><R><L><N><E><E><E><P><P><G><G><Q><D><P><W><K><L><L><K><E><Q><E><E><R><K><K><C><V><I><C><Q><D><Q><S><K><T><V><L><L><L><P><C><R><H><L><C><L><C><Q><A><C><T><E><I><L><M><R><H><P><V><Y><H><R><N><C><P><L><C><R><R><G><I><L><Q><T><L><N><V><Y><L> | E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud . Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1 . Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport . Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING . Also required to limit type I interferon response by promoting autophagic degradation of IRF3 .<BOP> | Q9BY78 |
Q8N3Y7 | RDHE2_HUMAN | Short-chain dehydrogenase/reductase family 16C member 5 | Homo | <M><S><F><N><L><Q><S><S><K><K><L><F><I><F><L><G><K><S><L><F><S><L><L><E><A><M><I><F><A><L><L><P><K><P><R><K><N><V><A><G><E><I><V><L><I><T><G><A><G><S><G><L><G><R><L><L><A><L><Q><F><A><R><L><G><S><V><L><V><L><W><D><I><N><K><E><G><N><E><E><T><C><K><M><A><R><E><A><G><A><T><R><V><H><A><Y><T><C><D><C><S><Q><K><E><G><V><Y><R><V><A><D><Q><V><K><K><E><V><G><D><V><S><I><L><I><N><N><A><G><I><V><T><G><K><K><F><L><D><C><P><D><E><L><M><E><K><S><F><D><V><N><F><K><A><H><L><W><T><Y><K><A><F><L><P><A><M><I><A><N><D><H><G><H><L><V><C><I><S><S><S><A><G><L><S><G><V><N><G><L><A><D><Y><C><A><S><K><F><A><A><F><G><F><A><E><S><V><F><V><E><T><F><V><Q><K><Q><K><G><I><K><T><T><I><V><C><P><F><F><I><K><T><G><M><F><E><G><C><T><T><G><C><P><S><L><L><P><I><L><E><P><K><Y><A><V><E><K><I><V><E><A><I><L><Q><E><K><M><Y><L><Y><M><P><K><L><L><Y><F><M><M><F><L><K><S><F><L><P><L><K><T><G><L><L><I><A><D><Y><L><G><I><L><H><A><M><D><G><F><V><D><Q><K><K><K><L> | Oxidoreductase with strong preference for NAD . Active in both the oxidative and reductive directions . Oxidizes all-trans-retinol in all-trans-retinaldehyde . No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH .<BOP> | Q8N3Y7 |
P43365 | MAGAC_HUMAN | MAGE12F antigen | Homo | <M><P><L><E><Q><R><S><Q><H><C><K><P><E><E><G><L><E><A><Q><G><E><A><L><G><L><V><G><A><Q><A><P><A><T><E><E><Q><E><T><A><S><S><S><S><T><L><V><E><V><T><L><R><E><V><P><A><A><E><S><P><S><P><P><H><S><P><Q><G><A><S><T><L><P><T><T><I><N><Y><T><L><W><S><Q><S><D><E><G><S><S><N><E><E><Q><E><G><P><S><T><F><P><D><L><E><T><S><F><Q><V><A><L><S><R><K><M><A><E><L><V><H><F><L><L><L><K><Y><R><A><R><E><P><F><T><K><A><E><M><L><G><S><V><I><R><N><F><Q><D><F><F><P><V><I><F><S><K><A><S><E><Y><L><Q><L><V><F><G><I><E><V><V><E><V><V><R><I><G><H><L><Y><I><L><V><T><C><L><G><L><S><Y><D><G><L><L><G><D><N><Q><I><V><P><K><T><G><L><L><I><I><V><L><A><I><I><A><K><E><G><D><C><A><P><E><E><K><I><W><E><E><L><S><V><L><E><A><S><D><G><R><E><D><S><V><F><A><H><P><R><K><L><L><T><Q><D><L><V><Q><E><N><Y><L><E><Y><R><Q><V><P><G><S><D><P><A><C><Y><E><F><L><W><G><P><R><A><L><V><E><T><S><Y><V><K><V><L><H><H><L><L><K><I><S><G><G><P><H><I><S><Y><P><P><L><H><E><W><A><F><R><E><G><E><E> | Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.<BOP> | P43365 |
Q71SY5 | MED25_HUMAN | p78 | Homo | <M><V><P><G><S><E><G><P><A><R><A><G><S><V><V><A><D><V><V><F><V><I><E><G><T><A><N><L><G><P><Y><F><E><G><L><R><K><H><Y><L><L><P><A><I><E><Y><F><N><G><G><P><P><A><E><T><D><F><G><G><D><Y><G><G><T><Q><Y><S><L><V><V><F><N><T><V><D><C><A><P><E><S><Y><V><Q><C><H><A><P><T><S><S><A><Y><E><F><V><T><W><L><D><G><I><K><F><M><G><G><G><G><E><S><C><S><L><I><A><E><G><L><S><T><A><L><Q><L><F><D><D><F><K><K><M><R><E><Q><I><G><Q><T><H><R><V><C><L><L><I><C><N><S><P><P><Y><L><L><P><A><V><E><S><T><T><Y><S><G><C><T><T><E><N><L><V><Q><Q><I><G><E><R><G><I><H><F><S><I><V><S><P><R><K><L><P><A><L><R><L><L><F><E><K><A><A><P><P><A><L><L><E><P><L><Q><P><P><T><D><V><S><Q><D><P><R><H><M><V><L><V><R><G><L><V><L><P><V><G><G><G><S><A><P><G><P><L><Q><S><K><Q><P><V><P><L><P><P><A><A><P><S><G><A><T><L><S><A><A><P><Q><Q><P><L><P><P><V><P><P><Q><Y><Q><V><P><G><N><L><S><A><A><Q><V><A><A><Q><N><A><V><E><A><A><K><N><Q><K><A><G><L><G><P><R><F><S><P><I><T><P><L><Q><Q><A><A><P><G><V><G><P><P><F><S><Q><A><P><A><P><Q><L><P><P><G><P><P><G><A><P><K><P><P><P><A><S><Q><P><S><L><V><S><T><V><A><P><G><S><G><L><A><P><T><A><Q><P><G><A><P><S><M><A><G><T><V><A><P><G><G><V><S><G><P><S><P><A><Q><L><G><A><P><A><L><G><G><Q><Q><S><V><S><N><K><L><L><A><W><S><G><V><L><E><W><Q><E><K><P><K><P><A><S><V><D><A><N><T><K><L><T><R><S><L><P><C><Q><V><Y><V><N><H><G><E><N><L><K><T><E><Q><W><P><Q><K><L><I><M><Q><L><I><P><Q><Q><L><L><T><T><L><G><P><L><F><R><N><S><R><M><V><Q><F><H><F><T><N><K><D><L><E><S><L><K><G><L><Y><R><I><M><G><N><G><F><A><G><C><V><H><F><P><H><T><A><P><C><E><V><R><V><L><M><L><L><Y><S><S><K><K><K><I><F><M><G><L><I><P><Y><D><Q><S><G><F><V><N><G><I><R><Q><V><I><T><N><H><K><Q><V><Q><Q><Q><K><L><E><Q><Q><Q><R><G><M><G><G><Q><Q><A><P><P><G><L><G><P><I><L><E><D><Q><A><R><P><S><Q><N><L><L><Q><L><R><P><P><Q><P><Q><P><Q><G><T><V><G><A><S><G><A><T><G><Q><P><Q><P><Q><G><T><A><Q><P><P><P><G><A><P><Q><G><P><P><G><A><A><S><G><P><P><P><P><G><P><I><L><R><P><Q><N><P><G><A><N><P><Q><L><R><S><L><L><L><N><P><P><P><P><Q><T><G><V><P><P><P><Q><A><S><L><H><H><L><Q><P><P><G><A><P><A><L><L><P><P><P><H><Q><G><L><G><Q><P><Q><L><G><P><P><L><L><H><P><P><P><A><Q><S><W><P><A><Q><L><P><P><R><A><P><L><P><G><Q><M><L><L><S><G><G><P><R><G><P><V><P><Q><P><G><L><Q><P><S><V><M><E><D><D><I><L><M><D><L><I> | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.<BOP> | Q71SY5 |
Q9Y2D0 | CAH5B_HUMAN | Carbonic anhydrase VB | Homo | <M><V><V><M><N><S><L><R><V><I><L><Q><A><S><P><G><K><L><L><W><R><K><F><Q><I><P><R><F><M><P><A><R><P><C><S><L><Y><T><C><T><Y><K><T><R><N><R><A><L><H><P><L><W><E><S><V><D><L><V><P><G><G><D><R><Q><S><P><I><N><I><R><W><R><D><S><V><Y><D><P><G><L><K><P><L><T><I><S><Y><D><P><A><T><C><L><H><V><W><N><N><G><Y><S><F><L><V><E><F><E><D><S><T><D><K><S><V><I><K><G><G><P><L><E><H><N><Y><R><L><K><Q><F><H><F><H><W><G><A><I><D><A><W><G><S><E><H><T><V><D><S><K><C><F><P><A><E><L><H><L><V><H><W><N><A><V><R><F><E><N><F><E><D><A><A><L><E><E><N><G><L><A><V><I><G><V><F><L><K><L><G><K><H><H><K><E><L><Q><K><L><V><D><T><L><P><S><I><K><H><K><D><A><L><V><E><F><G><S><F><D><P><S><C><L><M><P><T><C><P><D><Y><W><T><Y><S><G><S><L><T><T><P><P><L><S><E><S><V><T><W><I><I><K><K><Q><P><V><E><V><D><H><D><Q><L><E><Q><F><R><T><L><L><F><T><S><E><G><E><K><E><K><R><M><V><D><N><F><R><P><L><Q><P><L><M><N><R><T><V><R><S><S><F><R><H><D><Y><V><L><N><V><Q><A><K><P><K><P><A><T><S><Q><A><T><P> | Reversible hydration of carbon dioxide.<BOP> | Q9Y2D0 |
O15240 | VGF_HUMAN | Antimicrobial peptide VGF[554-577] | Homo | <M><K><A><L><R><L><S><A><S><A><L><F><C><L><L><L><I><N><G><L><G><A><A><P><P><G><R><P><E><A><Q><P><P><P><L><S><S><E><H><K><E><P><V><A><G><D><A><V><P><G><P><K><D><G><S><A><P><E><V><R><G><A><R><N><S><E><P><Q><D><E><G><E><L><F><Q><G><V><D><P><R><A><L><A><A><V><L><L><Q><A><L><D><R><P><A><S><P><P><A><P><S><G><S><Q><Q><G><P><E><E><E><A><A><E><A><L><L><T><E><T><V><R><S><Q><T><H><S><L><P><A><P><E><S><P><E><P><A><A><P><P><R><P><Q><T><P><E><N><G><P><E><A><S><D><P><S><E><E><L><E><A><L><A><S><L><L><Q><E><L><R><D><F><S><P><S><S><A><K><R><Q><Q><E><T><A><A><A><E><T><E><T><R><T><H><T><L><T><R><V><N><L><E><S><P><G><P><E><R><V><W><R><A><S><W><G><E><F><Q><A><R><V><P><E><R><A><P><L><P><P><P><A><P><S><Q><F><Q><A><R><M><P><D><S><G><P><L><P><E><T><H><K><F><G><E><G><V><S><S><P><K><T><H><L><G><E><A><L><A><P><L><S><K><A><Y><Q><G><V><A><A><P><F><P><K><A><R><R><P><E><S><A><L><L><G><G><S><E><A><G><E><R><L><L><Q><Q><G><L><A><Q><V><E><A><G><R><R><Q><A><E><A><T><R><Q><A><A><A><Q><E><E><R><L><A><D><L><A><S><D><L><L><L><Q><Y><L><L><Q><G><G><A><R><Q><R><G><L><G><G><R><G><L><Q><E><A><A><E><E><R><E><S><A><R><E><E><E><E><A><E><Q><E><R><R><G><G><E><E><R><V><G><E><E><D><E><E><A><A><E><A><E><A><E><A><E><E><A><E><R><A><R><Q><N><A><L><L><F><A><E><E><E><D><G><E><A><G><A><E><D><K><R><S><Q><E><E><T><P><G><H><R><R><K><E><A><E><G><T><E><E><G><G><E><E><E><D><D><E><E><M><D><P><Q><T><I><D><S><L><I><E><L><S><T><K><L><H><L><P><A><D><D><V><V><S><I><I><E><E><V><E><E><K><R><K><R><K><K><N><A><P><P><E><P><V><P><P><P><R><A><A><P><A><P><T><H><V><R><S><P><Q><P><P><P><P><A><P><A><P><A><R><D><E><L><P><D><W><N><E><V><L><P><P><W><D><R><E><E><D><E><V><Y><P><P><G><P><Y><H><P><F><P><N><Y><I><R><P><R><T><L><Q><P><P><S><A><L><R><R><R><H><Y><H><H><A><L><P><P><S><R><H><Y><P><G><R><E><A><Q><A><R><R><A><Q><E><E><A><E><A><E><E><R><R><L><Q><E><Q><E><E><L><E><N><Y><I><E><H><V><L><L><R><R><P> | Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.<BOP> | O15240 |
P23368 | MAOM_HUMAN | Malic enzyme 2 | Homo | <M><L><S><R><L><R><V><V><S><T><T><C><T><L><A><C><R><H><L><H><I><K><E><K><G><K><P><L><M><L><N><P><R><T><N><K><G><M><A><F><T><L><Q><E><R><Q><M><L><G><L><Q><G><L><L><P><P><K><I><E><T><Q><D><I><Q><A><L><R><F><H><R><N><L><K><K><M><T><S><P><L><E><K><Y><I><Y><I><M><G><I><Q><E><R><N><E><K><L><F><Y><R><I><L><Q><D><D><I><E><S><L><M><P><I><V><Y><T><P><T><V><G><L><A><C><S><Q><Y><G><H><I><F><R><R><P><K><G><L><F><I><S><I><S><D><R><G><H><V><R><S><I><V><D><N><W><P><E><N><H><V><K><A><V><V><V><T><D><G><E><R><I><L><G><L><G><D><L><G><V><Y><G><M><G><I><P><V><G><K><L><C><L><Y><T><A><C><A><G><I><R><P><D><R><C><L><P><V><C><I><D><V><G><T><D><N><I><A><L><L><K><D><P><F><Y><M><G><L><Y><Q><K><R><D><R><T><Q><Q><Y><D><D><L><I><D><E><F><M><K><A><I><T><D><R><Y><G><R><N><T><L><I><Q><F><E><D><F><G><N><H><N><A><F><R><F><L><R><K><Y><R><E><K><Y><C><T><F><N><D><D><I><Q><G><T><A><A><V><A><L><A><G><L><L><A><A><Q><K><V><I><S><K><P><I><S><E><H><K><I><L><F><L><G><A><G><E><A><A><L><G><I><A><N><L><I><V><M><S><M><V><E><N><G><L><S><E><Q><E><A><Q><K><K><I><W><M><F><D><K><Y><G><L><L><V><K><G><R><K><A><K><I><D><S><Y><Q><E><P><F><T><H><S><A><P><E><S><I><P><D><T><F><E><D><A><V><N><I><L><K><P><S><T><I><I><G><V><A><G><A><G><R><L><F><T><P><D><V><I><R><A><M><A><S><I><N><E><R><P><V><I><F><A><L><S><N><P><T><A><Q><A><E><C><T><A><E><E><A><Y><T><L><T><E><G><R><C><L><F><A><S><G><S><P><F><G><P><V><K><L><T><D><G><R><V><F><T><P><G><Q><G><N><N><V><Y><I><F><P><G><V><A><L><A><V><I><L><C><N><T><R><H><I><S><D><S><V><F><L><E><A><A><K><A><L><T><S><Q><L><T><D><E><E><L><A><Q><G><R><L><Y><P><P><L><A><N><I><Q><E><V><S><I><N><I><A><I><K><V><T><E><Y><L><Y><A><N><K><M><A><F><R><Y><P><E><P><E><D><K><A><K><Y><V><K><E><R><T><W><R><S><E><Y><D><S><L><L><P><D><V><Y><E><W><P><E><S><A><S><S><P><P><V><I><T><E> | NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.<BOP> | P23368 |
P26374 | RAE2_HUMAN | Rab escort protein 2 | Homo | <M><A><D><N><L><P><T><E><F><D><V><V><I><I><G><T><G><L><P><E><S><I><L><A><A><A><C><S><R><S><G><Q><R><V><L><H><I><D><S><R><S><Y><Y><G><G><N><W><A><S><F><S><F><S><G><L><L><S><W><L><K><E><Y><Q><Q><N><N><D><I><G><E><E><S><T><V><V><W><Q><D><L><I><H><E><T><E><E><A><I><T><L><R><K><K><D><E><T><I><Q><H><T><E><A><F><C><Y><A><S><Q><D><M><E><D><N><V><E><E><I><G><A><L><Q><K><N><P><S><L><G><V><S><N><T><F><T><E><V><L><D><S><A><L><P><E><E><S><Q><L><S><Y><F><N><S><D><E><M><P><A><K><H><T><Q><K><S><D><T><E><I><S><L><E><V><T><D><V><E><E><S><V><E><K><E><K><Y><C><G><D><K><T><C><M><H><T><V><S><D><K><D><G><D><K><D><E><S><K><S><T><V><E><D><K><A><D><E><P><I><R><N><R><I><T><Y><S><Q><I><V><K><E><G><R><R><F><N><I><D><L><V><S><K><L><L><Y><S><Q><G><L><L><I><D><L><L><I><K><S><D><V><S><R><Y><V><E><F><K><N><V><T><R><I><L><A><F><R><E><G><K><V><E><Q><V><P><C><S><R><A><D><V><F><N><S><K><E><L><T><M><V><E><K><R><M><L><M><K><F><L><T><F><C><L><E><Y><E><Q><H><P><D><E><Y><Q><A><F><R><Q><C><S><F><S><E><Y><L><K><T><K><K><L><T><P><N><L><Q><H><F><V><L><H><S><I><A><M><T><S><E><S><S><C><T><T><I><D><G><L><N><A><T><K><N><F><L><Q><C><L><G><R><F><G><N><T><P><F><L><F><P><L><Y><G><Q><G><E><I><P><Q><G><F><C><R><M><C><A><V><F><G><G><I><Y><C><L><R><H><K><V><Q><C><F><V><V><D><K><E><S><G><R><C><K><A><I><I><D><H><F><G><Q><R><I><N><A><K><Y><F><I><V><E><D><S><Y><L><S><E><E><T><C><S><N><V><Q><Y><K><Q><I><S><R><A><V><L><I><T><D><Q><S><I><L><K><T><D><L><D><Q><Q><T><S><I><L><I><V><P><P><A><E><P><G><A><C><A><V><R><V><T><E><L><C><S><S><T><M><T><C><M><K><D><T><Y><L><V><H><L><T><C><S><S><S><K><T><A><R><E><D><L><E><S><V><V><K><K><L><F><T><P><Y><T><E><T><E><I><N><E><E><E><L><T><K><P><R><L><L><W><A><L><Y><F><N><M><R><D><S><S><G><I><S><R><S><S><Y><N><G><L><P><S><N><V><Y><V><C><S><G><P><D><C><G><L><G><N><E><H><A><V><K><Q><A><E><T><L><F><Q><E><I><F><P><T><E><E><F><C><P><P><P><P><N><P><E><D><I><I><F><D><G><D><D><K><Q><P><E><A><P><G><T><N><N><V><V><M><A><K><L><E><S><S><E><E><S><K><N><L><E><S><P><E><K><H><L><Q><N> | Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.<BOP> | P26374 |
Q8NHB1 | OR2V1_HUMAN | Olfactory receptor 2V1 | Homo | <M><G><R><W><V><N><Q><S><Y><T><D><G><F><F><L><L><G><I><F><S><H><S><Q><T><D><L><V><L><F><S><A><V><M><V><V><F><T><V><A><L><C><G><N><V><L><L><I><F><L><I><Y><L><D><A><G><L><H><T><P><M><Y><F><F><L><S><Q><L><S><L><M><D><L><M><L><V><C><N><I><V><P><K><M><A><A><N><F><L><S><G><R><K><S><I><S><F><V><G><C><G><I><Q><I><G><F><F><V><S><L><V><G><S><E><G><L><L><L><G><L><M><A><Y><D><R><Y><V><A><V><S><H><P><L><H><Y><P><I><L><M><N><Q><R><V><C><L><Q><I><T><G><S><S><W><A><F><G><I><I><D><G><V><I><Q><M><V><A><A><M><G><L><P><Y><C><G><S><R><S><V><D><H><F><F><C><E><V><Q><A><L><L><K><L><A><C><A><D><T><S><L><F><D><T><L><L><F><A><C><C><V><F><M><L><L><L><P><F><S><I><I><M><A><S><Y><A><C><I><L><G><A><V><L><R><I><R><S><A><Q><A><W><K><K><A><L><A><T><C><S><S><H><L><T><A><V><T><L><F><Y><G><A><A><M><F><M><Y><L><R><P><R><R><Y><R><A><P><S><H><D><K><V><A><S><I><F><Y><T><V><L><T><P><M><L><N><P><L><I><Y><S><L><R><N><G><E><V><M><G><A><L><R><K><G><L><D><R><C><R><I><G><S><Q><H> | Odorant receptor.<BOP> | Q8NHB1 |
P50591 | TNF10_HUMAN | TNF-related apoptosis-inducing ligand | Homo | <M><A><M><M><E><V><Q><G><G><P><S><L><G><Q><T><C><V><L><I><V><I><F><T><V><L><L><Q><S><L><C><V><A><V><T><Y><V><Y><F><T><N><E><L><K><Q><M><Q><D><K><Y><S><K><S><G><I><A><C><F><L><K><E><D><D><S><Y><W><D><P><N><D><E><E><S><M><N><S><P><C><W><Q><V><K><W><Q><L><R><Q><L><V><R><K><M><I><L><R><T><S><E><E><T><I><S><T><V><Q><E><K><Q><Q><N><I><S><P><L><V><R><E><R><G><P><Q><R><V><A><A><H><I><T><G><T><R><G><R><S><N><T><L><S><S><P><N><S><K><N><E><K><A><L><G><R><K><I><N><S><W><E><S><S><R><S><G><H><S><F><L><S><N><L><H><L><R><N><G><E><L><V><I><H><E><K><G><F><Y><Y><I><Y><S><Q><T><Y><F><R><F><Q><E><E><I><K><E><N><T><K><N><D><K><Q><M><V><Q><Y><I><Y><K><Y><T><S><Y><P><D><P><I><L><L><M><K><S><A><R><N><S><C><W><S><K><D><A><E><Y><G><L><Y><S><I><Y><Q><G><G><I><F><E><L><K><E><N><D><R><I><F><V><S><V><T><N><E><H><L><I><D><M><D><H><E><A><S><F><F><G><A><F><L><V><G> | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG . Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.<BOP> | P50591 |
Q96B18 | DACT3_HUMAN | Dapper antagonist of catenin 3 | Homo | <M><I><R><A><F><S><F><P><V><S><P><E><R><G><R><L><R><G><W><L><E><G><S><L><A><G><L><C><E><L><H><W><L><R><E><R><Q><E><Y><R><V><Q><Q><A><L><R><L><A><Q><P><G><M><G><G><A><E><A><E><D><E><E><D><A><D><E><D><E><D><A><A><A><A><R><R><A><A><A><A><L><E><E><Q><L><E><A><L><P><G><L><V><W><D><L><G><Q><Q><L><G><D><L><S><L><E><S><G><G><L><E><Q><E><S><G><R><S><S><G><F><Y><E><D><P><S><S><T><G><G><P><D><S><P><P><S><T><F><C><G><D><S><G><F><S><G><S><S><S><Y><G><R><L><G><P><S><E><P><R><G><I><Y><A><S><E><R><P><K><S><L><G><D><A><S><P><S><A><P><E><V><V><G><A><R><A><A><V><P><R><S><F><S><A><P><Y><P><T><A><G><G><S><A><G><P><E><A><C><S><S><A><E><R><R><A><R><A><G><P><F><L><T><P><S><P><L><H><A><V><A><M><R><S><P><R><P><C><G><R><P><P><T><D><S><P><D><A><G><G><A><G><R><P><L><D><G><Y><I><S><A><L><L><R><R><R><R><R><R><G><A><G><Q><P><R><T><S><P><G><G><A><D><G><G><P><R><R><Q><N><S><V><R><Q><R><P><P><D><A><S><P><S><P><G><S><A><R><P><A><R><E><P><S><L><E><R><V><G><G><H><P><T><S><P><A><A><L><S><R><A><W><A><S><S><W><E><S><E><A><A><P><E><P><A><A><P><P><A><A><P><S><P><P><D><S><P><A><E><G><R><L><V><K><A><Q><Y><I><P><G><A><Q><A><A><T><R><G><L><P><G><R><A><A><R><R><K><P><P><P><L><T><R><G><R><S><V><E><Q><S><P><P><R><E><R><P><R><A><A><G><R><R><G><R><M><A><E><A><S><G><R><R><G><S><P><R><A><R><K><A><S><R><S><Q><S><E><T><S><L><L><G><R><A><S><A><V><P><S><G><P><P><K><Y><P><T><A><E><R><E><E><P><R><P><P><R><P><R><R><G><P><A><P><T><L><A><A><Q><A><A><G><S><C><R><R><W><R><S><T><A><E><I><D><A><A><D><G><R><R><V><R><P><R><A><P><A><A><R><V><P><G><P><G><P><S><P><S><A><P><Q><R><R><L><L><Y><G><C><A><G><S><D><S><E><C><S><A><G><R><L><G><P><L><G><R><R><G><P><A><G><G><V><G><G><G><Y><G><E><S><E><S><S><A><S><E><G><E><S><P><A><F><S><S><A><S><S><D><S><D><G><S><G><G><L><V><W><P><Q><Q><L><V><A><A><T><A><A><S><G><G><G><A><G><A><G><A><P><A><G><P><A><K><V><F><V><K><I><K><A><S><H><A><L><K><K><K><I><L><R><F><R><S><G><S><L><K><V><M><T><T><V> | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.<BOP> | Q96B18 |
Q92674 | CENPI_HUMAN | Leucine-rich primary response protein 1 | Homo | <M><S><P><Q><K><R><V><K><N><V><Q><A><Q><N><R><T><S><Q><G><S><S><S><F><Q><T><T><L><S><A><W><K><V><K><Q><D><P><S><N><S><K><N><I><S><K><H><G><Q><N><N><P><V><G><D><Y><E><H><A><D><D><Q><A><E><E><D><A><L><Q><M><A><V><G><Y><F><E><K><G><P><I><K><A><S><Q><N><K><D><K><T><L><E><K><H><L><K><T><V><E><N><V><A><W><K><N><G><L><A><S><E><E><I><D><I><L><L><N><I><A><L><S><G><K><F><G><N><A><V><N><T><R><I><L><K><C><M><I><P><A><T><V><I><S><E><D><S><V><V><K><A><V><S><W><L><C><V><G><K><C><S><G><S><T><K><V><L><F><Y><R><W><L><V><A><M><F><D><F><I><D><R><K><E><Q><I><N><L><L><Y><G><F><F><F><A><S><L><Q><D><D><A><L><C><P><Y><V><C><H><L><L><Y><L><L><T><K><K><E><N><V><K><P><F><R><V><R><K><L><L><D><L><Q><A><K><M><G><M><Q><P><H><L><Q><A><L><L><S><L><Y><K><F><F><A><P><A><L><I><S><V><S><L><P><V><R><K><K><I><Y><F><K><N><S><E><N><L><W><K><T><A><L><L><A><V><K><Q><R><N><R><G><P><S><P><E><P><L><K><L><M><L><G><P><A><N><V><R><P><L><K><R><K><W><N><S><L><S><V><I><P><V><L><N><S><S><S><Y><T><K><E><C><G><K><K><E><M><S><L><S><D><C><L><N><R><S><G><S><F><P><L><E><Q><L><Q><S><F><P><Q><L><L><Q><N><I><H><C><L><E><L><P><S><Q><M><G><S><V><L><N><N><S><L><L><L><H><Y><I><N><C><V><R><D><E><P><V><L><L><R><F><Y><Y><W><L><S><Q><T><L><Q><E><E><C><I><W><Y><K><V><N><N><Y><E><H><G><K><E><F><T><N><F><L><D><T><I><I><R><A><E><C><F><L><Q><E><G><F><Y><S><C><E><A><F><L><Y><K><S><L><P><L><W><D><G><L><C><C><R><S><Q><F><L><Q><L><V><S><W><I><P><F><S><S><F><S><E><V><K><P><L><L><F><D><H><L><A><Q><L><F><F><T><S><T><I><Y><F><K><C><S><V><L><Q><S><L><K><E><L><L><Q><N><W><L><L><W><L><S><M><D><I><H><M><K><P><V><T><N><S><P><L><E><T><T><L><G><G><S><M><N><S><V><S><K><L><I><H><Y><V><G><W><L><S><T><T><A><M><R><L><E><S><N><N><T><F><L><L><H><F><I><L><D><F><Y><E><K><V><C><D><I><Y><I><N><Y><N><L><P><L><V><V><L><F><P><P><G><I><F><Y><S><A><L><L><S><L><D><T><S><I><L><N><Q><L><C><F><I><M><H><R><Y><R><K><N><L><T><A><A><K><K><N><E><L><V><Q><K><T><K><S><E><F><N><F><S><S><K><T><Y><Q><E><F><N><H><Y><L><T><S><M><V><G><C><L><W><T><S><K><P><F><G><K><G><I><Y><I><D><P><E><I><L><E><K><T><G><V><A><E><Y><K><N><S><L><N><V><V><H><H><P><S><F><L><S><Y><A><V><S><F><L><L><Q><E><S><P><E><E><R><T><V><N><V><S><S><I><R><G><K><K><W><S><W><Y><L><D><Y><L><F><S><Q><G><L><Q><G><L><K><L><F><I><R><S><S><V><H><H><S><S><I><P><R><A><E><G><I><N><C><N><N><Q><Y> | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.<BOP> | Q92674 |
P59666 | DEF3_HUMAN | HNP-2 | Homo | <M><R><T><L><A><I><L><A><A><I><L><L><V><A><L><Q><A><Q><A><E><P><L><Q><A><R><A><D><E><V><A><A><A><P><E><Q><I><A><A><D><I><P><E><V><V><V><S><L><A><W><D><E><S><L><A><P><K><H><P><G><S><R><K><N><M><D><C><Y><C><R><I><P><A><C><I><A><G><E><R><R><Y><G><T><C><I><Y><Q><G><R><L><W><A><F><C><C> | Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.<BOP> | P59666 |
Q8NGF8 | OR4B1_HUMAN | Olfactory receptor OR11-106 | Homo | <M><A><S><T><S><N><V><T><E><L><I><F><T><G><L><F><Q><D><P><A><V><Q><S><V><C><F><V><V><F><L><P><V><Y><L><A><T><V><V><G><N><G><L><I><V><L><T><V><S><I><S><K><S><L><D><S><P><M><Y><F><F><L><S><C><L><S><L><V><E><I><S><Y><S><S><T><I><A><P><K><F><I><I><D><L><L><A><K><I><K><T><I><S><L><E><G><C><L><T><Q><I><F><F><F><H><F><F><G><V><A><E><I><L><L><I><V><V><M><A><Y><D><C><Y><V><A><I><C><K><P><L><H><Y><M><N><I><I><S><R><Q><L><C><H><L><L><V><A><G><S><W><L><G><G><F><C><H><S><I><I><Q><I><L><V><I><I><Q><L><P><F><C><G><P><N><V><I><D><H><Y><F><C><D><L><Q><P><L><F><K><L><A><C><T><D><T><F><M><E><G><V><I><V><L><A><N><S><G><L><F><S><V><F><S><F><L><I><L><V><S><S><Y><I><V><I><L><V><N><L><R><N><H><S><A><E><G><R><H><K><A><L><S><T><C><A><S><H><I><T><V><V><I><L><F><F><G><P><A><I><F><L><Y><M><R><P><S><S><T><F><T><E><D><K><L><V><A><V><F><Y><T><V><I><T><P><M><L><N><P><I><I><Y><T><L><R><N><A><E><V><K><I><A><I><R><R><L><W><S><K><K><E><N><P><G><R><E> | Odorant receptor.<BOP> | Q8NGF8 |
Q9NS28 | RGS18_HUMAN | Regulator of G-protein signaling 18 | Homo | <M><E><T><T><L><L><F><F><S><Q><I><N><M><C><E><S><K><E><K><T><F><F><K><L><I><H><G><S><G><K><E><E><T><S><K><E><A><K><I><R><A><K><E><K><R><N><R><L><S><L><L><V><Q><K><P><E><F><H><E><D><T><R><S><S><R><S><G><H><L><A><K><E><T><R><V><S><P><E><E><A><V><K><W><G><E><S><F><D><K><L><L><S><H><R><D><G><L><E><A><F><T><R><F><L><K><T><E><F><S><E><E><N><I><E><F><W><I><A><C><E><D><F><K><K><S><K><G><P><Q><Q><I><H><L><K><A><K><A><I><Y><E><K><F><I><Q><T><D><A><P><K><E><V><N><L><D><F><H><T><K><E><V><I><T><N><S><I><T><Q><P><T><L><H><S><F><D><A><A><Q><S><R><V><Y><Q><L><M><E><Q><D><S><Y><T><R><F><L><K><S><D><I><Y><L><D><L><M><E><G><R><P><Q><R><P><T><N><L><R><R><R><S><R><S><F><T><C><N><E><F><Q><D><V><Q><S><D><V><A><I><W><L> | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.<BOP> | Q9NS28 |
Q8TDH9 | BL1S5_HUMAN | Protein Muted homolog | Homo | <M><S><G><G><G><T><E><T><P><V><G><C><E><A><A><P><G><G><G><S><K><K><R><D><S><L><G><T><A><G><S><A><H><L><I><I><K><D><L><G><E><I><H><S><R><L><L><D><H><R><P><V><I><Q><G><E><T><R><Y><F><V><K><E><F><E><E><K><R><G><L><R><E><M><R><V><L><E><N><L><K><N><M><I><H><E><T><N><E><H><T><L><P><K><C><R><D><T><M><R><D><S><L><S><Q><V><L><Q><R><L><Q><A><A><N><D><S><V><C><R><L><Q><Q><R><E><Q><E><R><K><K><I><H><S><D><H><L><V><A><S><E><K><Q><H><M><L><Q><W><D><N><F><M><K><E><Q><P><N><K><R><A><E><V><D><E><E><H><R><K><A><M><E><R><L><K><E><Q><Y><A><E><M><E><K><D><L><A><K><F><S><T><F> | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes . In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.<BOP> | Q8TDH9 |
A6NM45 | CLD24_HUMAN | Claudin-21 | Homo | <M><A><L><I><F><R><T><A><M><Q><S><V><G><L><L><L><S><L><L><G><W><I><L><S><I><I><T><T><Y><L><P><H><W><K><N><L><N><L><D><L><N><E><M><E><N><W><T><M><G><L><W><Q><T><C><V><I><Q><E><E><V><G><M><Q><C><K><D><F><D><S><F><L><A><L><P><A><E><L><R><V><S><R><I><L><M><F><L><S><N><G><L><G><F><L><G><L><L><V><S><G><F><G><L><D><C><L><R><I><G><E><S><Q><R><D><L><K><R><R><L><L><I><L><G><G><I><L><S><W><A><S><G><I><T><A><L><V><P><V><S><W><V><A><H><K><T><V><Q><E><F><W><D><E><N><V><P><D><F><V><P><R><W><E><F><G><E><A><L><F><L><G><W><F><A><G><L><S><L><L><L><G><G><C><L><L><N><C><A><A><C><S><S><H><A><P><L><A><L><G><H><Y><A><V><A><Q><M><Q><T><Q><C><P><Y><L><E><D><G><T><A><D><P><Q><V> | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP> | A6NM45 |
P04233 | HG2A_HUMAN | Class-II-associated invariant chain peptide | Homo | <M><H><R><R><R><S><R><S><C><R><E><D><Q><K><P><V><M><D><D><Q><R><D><L><I><S><N><N><E><Q><L><P><M><L><G><R><R><P><G><A><P><E><S><K><C><S><R><G><A><L><Y><T><G><F><S><I><L><V><T><L><L><L><A><G><Q><A><T><T><A><Y><F><L><Y><Q><Q><Q><G><R><L><D><K><L><T><V><T><S><Q><N><L><Q><L><E><N><L><R><M><K><L><P><K><P><P><K><P><V><S><K><M><R><M><A><T><P><L><L><M><Q><A><L><P><M><G><A><L><P><Q><G><P><M><Q><N><A><T><K><Y><G><N><M><T><E><D><H><V><M><H><L><L><Q><N><A><D><P><L><K><V><Y><P><P><L><K><G><S><F><P><E><N><L><R><H><L><K><N><T><M><E><T><I><D><W><K><V><F><E><S><W><M><H><H><W><L><L><F><E><M><S><R><H><S><L><E><Q><K><P><T><D><A><P><P><K><V><L><T><K><C><Q><E><E><V><S><H><I><P><A><V><H><P><G><S><F><R><P><K><C><D><E><N><G><N><Y><L><P><L><Q><C><Y><G><S><I><G><Y><C><W><C><V><F><P><N><G><T><E><V><P><N><T><R><S><R><G><H><H><N><C><S><E><S><L><E><L><E><D><P><S><S><G><L><G><V><T><K><Q><D><L><G><P><V><P><M> | Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 . Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform .<BOP> | P04233 |
Q6QN14 | U17L6_HUMAN | Ubiquitin-specific-processing protease 17-like protein 6 | Homo | <M><E><D><D><S><L><Y><L><R><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y><M><L><S><R><E><H><S><Q><T><C><H><R><H><K><G><C><M><L><C><T><M><Q><A><H><I><T><R><A><L><H><N><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><A><H><E><F><L><M><F><T><V><D><A><M><K><K><A><C><L><P><G><H><K><Q><V><D><H><H><S><K><D><T><T><L><I><H><Q><I><F><G><G><Y><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><Q><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><V><C><L><Q><R><A><P><A><S><K><T><L><T><L><H><T><S><A><K><V><L><I><L><V><L><K><R><F><S><D><V><T><G><N><K><I><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><Q><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><N><G><H><Y><F><S><Y><V><K><A><Q><E><G><Q><W><Y><K><M><D><D><A><E><V><T><A><S><S><I><T><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><S><E><D> | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, cell migration, and the cellular response to viral infection. Seems to be non-functional in the regulation of apoptosis.<BOP> | Q6QN14 |
Q8N143 | BCL6B_HUMAN | Zinc finger protein 62 | Homo | <M><G><S><P><A><A><P><E><G><A><L><G><Y><V><R><E><F><T><R><H><S><S><D><V><L><G><N><L><N><E><L><R><L><R><G><I><L><T><D><V><T><L><L><V><G><G><Q><P><L><R><A><H><K><A><V><L><I><A><C><S><G><F><F><Y><S><I><F><R><G><R><A><G><V><G><V><D><V><L><S><L><P><G><G><P><E><A><R><G><F><A><P><L><L><D><F><M><Y><T><S><R><L><R><L><S><P><A><T><A><P><A><V><L><A><A><A><T><Y><L><Q><M><E><H><V><V><Q><A><C><H><R><F><I><Q><A><S><Y><E><P><L><G><I><S><L><R><P><L><E><A><E><P><P><T><P><P><T><A><P><P><P><G><S><P><R><R><S><E><G><H><P><D><P><P><T><E><S><R><S><C><S><Q><G><P><P><S><P><A><S><P><D><P><K><A><C><N><W><K><K><Y><K><Y><I><V><L><N><S><Q><A><S><Q><A><G><S><L><V><G><E><R><S><S><G><Q><P><C><P><Q><A><R><L><P><S><G><D><E><A><S><S><S><S><S><S><S><S><S><S><S><E><E><G><P><I><P><G><P><Q><S><R><L><S><P><T><A><A><T><V><Q><F><K><C><G><A><P><A><S><T><P><Y><L><L><T><S><Q><A><Q><D><T><S><G><S><P><S><E><R><A><R><P><L><P><G><S><E><F><F><S><C><Q><N><C><E><A><V><A><G><C><S><S><G><L><D><S><L><V><P><G><D><E><D><K><P><Y><K><C><Q><L><C><R><S><S><F><R><Y><K><G><N><L><A><S><H><R><T><V><H><T><G><E><K><P><Y><H><C><S><I><C><G><A><R><F><N><R><P><A><N><L><K><T><H><S><R><I><H><S><G><E><K><P><Y><K><C><E><T><C><G><S><R><F><V><Q><V><A><H><L><R><A><H><V><L><I><H><T><G><E><K><P><Y><P><C><P><T><C><G><T><R><F><R><H><L><Q><T><L><K><S><H><V><R><I><H><T><G><E><K><P><Y><H><C><D><P><C><G><L><H><F><R><H><K><S><Q><L><R><L><H><L><R><Q><K><H><G><A><A><T><N><T><K><V><H><Y><H><I><L><G><G><P> | Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.<BOP> | Q8N143 |
P31689 | DNJA1_HUMAN | Human DnaJ protein 2 | Homo | <M><V><K><E><T><T><Y><Y><D><V><L><G><V><K><P><N><A><T><Q><E><E><L><K><K><A><Y><R><K><L><A><L><K><Y><H><P><D><K><N><P><N><E><G><E><K><F><K><Q><I><S><Q><A><Y><E><V><L><S><D><A><K><K><R><E><L><Y><D><K><G><G><E><Q><A><I><K><E><G><G><A><G><G><G><F><G><S><P><M><D><I><F><D><M><F><F><G><G><G><G><R><M><Q><R><E><R><R><G><K><N><V><V><H><Q><L><S><V><T><L><E><D><L><Y><N><G><A><T><R><K><L><A><L><Q><K><N><V><I><C><D><K><C><E><G><R><G><G><K><K><G><A><V><E><C><C><P><N><C><R><G><T><G><M><Q><I><R><I><H><Q><I><G><P><G><M><V><Q><Q><I><Q><S><V><C><M><E><C><Q><G><H><G><E><R><I><S><P><K><D><R><C><K><S><C><N><G><R><K><I><V><R><E><K><K><I><L><E><V><H><I><D><K><G><M><K><D><G><Q><K><I><T><F><H><G><E><G><D><Q><E><P><G><L><E><P><G><D><I><I><I><V><L><D><Q><K><D><H><A><V><F><T><R><R><G><E><D><L><F><M><C><M><D><I><Q><L><V><E><A><L><C><G><F><Q><K><P><I><S><T><L><D><N><R><T><I><V><I><T><S><H><P><G><Q><I><V><K><H><G><D><I><K><C><V><L><N><E><G><M><P><I><Y><R><R><P><Y><E><K><G><R><L><I><I><E><F><K><V><N><F><P><E><N><G><F><L><S><P><D><K><L><S><L><L><E><K><L><L><P><E><R><K><E><V><E><E><T><D><E><M><D><Q><V><E><L><V><D><F><D><P><N><Q><E><R><R><R><H><Y><N><G><E><A><Y><E><D><D><E><H><H><P><R><G><G><V><Q><C><Q><T><S> | Co-chaperone for HSPA8/Hsc70 . Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) . Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis . Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV .<BOP> | P31689 |
O96006 | ZBED1_HUMAN | dREF homolog | Homo | <M><E><N><K><S><L><E><S><S><Q><T><D><L><K><L><V><A><H><P><R><A><K><S><K><V><W><K><Y><F><G><F><D><T><N><A><E><G><C><I><L><Q><W><K><K><I><Y><C><R><I><C><M><A><Q><I><A><Y><S><G><N><T><S><N><L><S><Y><H><L><E><K><N><H><P><E><E><F><C><E><F><V><K><S><N><T><E><Q><M><R><E><A><F><A><T><A><F><S><K><L><K><P><E><S><S><Q><Q><P><G><Q><D><A><L><A><V><K><A><G><H><G><Y><D><S><K><K><Q><Q><E><L><T><A><A><V><L><G><L><I><C><E><G><L><Y><P><A><S><I><V><D><E><P><T><F><K><V><L><L><K><T><A><D><P><R><Y><E><L><P><S><R><K><Y><I><S><T><K><A><I><P><E><K><Y><G><A><V><R><E><V><I><L><K><E><L><A><E><A><T><W><C><G><I><S><T><D><M><W><R><S><E><N><Q><N><R><A><Y><V><T><L><A><A><H><F><L><G><L><G><A><P><N><C><L><S><M><G><S><R><C><L><K><T><F><E><V><P><E><E><N><T><A><E><T><I><T><R><V><L><Y><E><V><F><I><E><W><G><I><S><A><K><V><F><G><A><T><T><N><Y><G><K><D><I><V><K><A><C><S><L><L><D><V><A><V><H><M><P><C><L><G><H><T><F><N><A><G><I><Q><Q><A><F><Q><L><P><K><L><G><A><L><L><S><R><C><R><K><L><V><E><Y><F><Q><Q><S><A><V><A><M><Y><M><L><Y><E><K><Q><K><Q><Q><N><V><A><H><C><M><L><V><S><N><R><V><S><W><W><G><S><T><L><A><M><L><Q><R><L><K><E><Q><Q><F><V><I><A><G><V><L><V><E><D><S><N><N><H><H><L><M><L><E><A><S><E><W><A><T><I><E><G><L><V><E><L><L><Q><P><F><K><Q><V><A><E><M><L><S><A><S><R><Y><P><T><I><S><M><V><K><P><L><L><H><M><L><L><N><T><T><L><N><I><K><E><T><D><S><K><E><L><S><M><A><K><E><V><I><A><K><E><L><S><K><T><Y><Q><E><T><P><E><I><D><M><F><L><N><V><A><T><F><L><D><P><R><Y><K><R><L><P><F><L><S><A><F><E><R><Q><Q><V><E><N><R><V><V><E><E><A><K><G><L><L><D><K><V><K><D><G><G><Y><R><P><A><E><D><K><I><F><P><V><P><E><E><P><P><V><K><K><L><M><R><T><S><T><P><P><P><A><S><V><I><N><N><M><L><A><E><I><F><C><Q><T><G><G><V><E><D><Q><E><E><W><H><A><Q><V><V><E><E><L><S><N><F><K><S><Q><K><V><L><G><L><N><E><D><P><L><K><W><W><S><D><R><L><A><L><F><P><L><L><P><K><V><L><Q><K><Y><W><C><V><T><A><T><R><V><A><P><E><R><L><F><G><S><A><A><N><V><V><S><A><K><R><N><R><L><A><P><A><H><V><D><E><Q><V><F><L><Y><E><N><A><R><S><G><A><E><A><E><P><E><D><Q><D><E><G><E><W><G><L><D><Q><E><Q><V><F><S><L><G><D><G><V><S><G><G><F><F><G><I><R><D><S><S><F><L> | (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.<BOP> | O96006 |
P49221 | TGM4_HUMAN | Transglutaminase-4 | Homo | <M><M><D><A><S><K><E><L><Q><V><L><H><I><D><F><L><N><Q><D><N><A><V><S><H><H><T><W><E><F><Q><T><S><S><P><V><F><R><R><G><Q><V><F><H><L><R><L><V><L><N><Q><P><L><Q><S><Y><H><Q><L><K><L><E><F><S><T><G><P><N><P><S><I><A><K><H><T><L><V><V><L><D><P><R><T><P><S><D><H><Y><N><W><Q><A><T><L><Q><N><E><S><G><K><E><V><T><V><A><V><T><S><S><P><N><A><I><L><G><K><Y><Q><L><N><V><K><T><G><N><H><I><L><K><S><E><E><N><I><L><Y><L><L><F><N><P><W><C><K><E><D><M><V><F><M><P><D><E><D><E><R><K><E><Y><I><L><N><D><T><G><C><H><Y><V><G><A><A><R><S><I><K><C><K><P><W><N><F><G><Q><F><E><K><N><V><L><D><C><C><I><S><L><L><T><E><S><S><L><K><P><T><D><R><R><D><P><V><L><V><C><R><A><M><C><A><M><M><S><F><E><K><G><Q><G><V><L><I><G><N><W><T><G><D><Y><E><G><G><T><A><P><Y><K><W><T><G><S><A><P><I><L><Q><Q><Y><Y><N><T><K><Q><A><V><C><F><G><Q><C><W><V><F><A><G><I><L><T><T><V><L><R><A><L><G><I><P><A><R><S><V><T><G><F><D><S><A><H><D><T><E><R><N><L><T><V><D><T><Y><V><N><E><N><G><E><K><I><T><S><M><T><H><D><S><V><W><N><F><H><V><W><T><D><A><W><M><K><R><P><D><L><P><K><G><Y><D><G><W><Q><A><V><D><A><T><P><Q><E><R><S><Q><G><V><F><C><C><G><P><S><P><L><T><A><I><R><K><G><D><I><F><I><V><Y><D><T><R><F><V><F><S><E><V><N><G><D><R><L><I><W><L><V><K><M><V><N><G><Q><E><E><L><H><V><I><S><M><E><T><T><S><I><G><K><N><I><S><T><K><A><V><G><Q><D><R><R><R><D><I><T><Y><E><Y><K><Y><P><E><G><S><S><E><E><R><Q><V><M><D><H><A><F><L><L><L><S><S><E><R><E><H><R><R><P><V><K><E><N><F><L><H><M><S><V><Q><S><D><D><V><L><L><G><N><S><V><N><F><T><V><I><L><K><R><K><T><A><A><L><Q><N><V><N><I><L><G><S><F><E><L><Q><L><Y><T><G><K><K><M><A><K><L><C><D><L><N><K><T><S><Q><I><Q><G><Q><V><S><E><V><T><L><T><L><D><S><K><T><Y><I><N><S><L><A><I><L><D><D><E><P><V><I><R><G><F><I><I><A><E><I><V><E><S><K><E><I><M><A><S><E><V><F><T><S><F><Q><Y><P><E><F><S><I><E><L><P><N><T><G><R><I><G><Q><L><L><V><C><N><C><I><F><K><N><T><L><A><I><P><L><T><D><V><K><F><S><L><E><S><L><G><I><S><S><L><Q><T><S><D><H><G><T><V><Q><P><G><E><T><I><Q><S><Q><I><K><C><T><P><I><K><T><G><P><K><K><F><I><V><K><L><S><S><K><Q><V><K><E><I><N><A><Q><K><I><V><L><I><T><K> | Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.<BOP> | P49221 |
O95925 | EPPI_HUMAN | WAP four-disulfide core domain protein 7 | Homo | <M><G><S><S><G><L><L><S><L><L><V><L><F><V><L><L><A><N><V><Q><G><P><G><L><T><D><W><L><F><P><R><R><C><P><K><I><R><E><E><C><E><F><Q><E><R><D><V><C><T><K><D><R><Q><C><Q><D><N><K><K><C><C><V><F><S><C><G><K><K><C><L><D><L><K><Q><D><V><C><E><M><P><K><E><T><G><P><C><L><A><Y><F><L><H><W><W><Y><D><K><K><D><N><T><C><S><M><F><V><Y><G><G><C><Q><G><N><N><N><N><F><Q><S><K><A><N><C><L><N><T><C><K><N><K><R><F><P> | Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.<BOP> | O95925 |
Q9BZR9 | TRIM8_HUMAN | Tripartite motif-containing protein 8 | Homo | <M><A><E><N><W><K><N><C><F><E><E><E><L><I><C><P><I><C><L><H><V><F><V><E><P><V><Q><L><P><C><K><H><N><F><C><R><G><C><I><G><E><A><W><A><K><D><S><G><L><V><R><C><P><E><C><N><Q><A><Y><N><Q><K><P><G><L><E><K><N><L><K><L><T><N><I><V><E><K><F><N><A><L><H><V><E><K><P><P><A><A><L><H><C><V><F><C><R><R><G><P><P><L><P><A><Q><K><V><C><L><R><C><E><A><P><C><C><Q><S><H><V><Q><T><H><L><Q><Q><P><S><T><A><R><G><H><L><L><V><E><A><D><D><V><R><A><W><S><C><P><Q><H><N><A><Y><R><L><Y><H><C><E><A><E><Q><V><A><V><C><Q><Y><C><C><Y><Y><S><G><A><H><Q><G><H><S><V><C><D><V><E><I><R><R><N><E><I><R><K><M><L><M><K><Q><Q><D><R><L><E><E><R><E><Q><D><I><E><D><Q><L><Y><K><L><E><S><D><K><R><L><V><E><E><K><V><N><Q><L><K><E><E><V><R><L><Q><Y><E><K><L><H><Q><L><L><D><E><D><L><R><Q><T><V><E><V><L><D><K><A><Q><A><K><F><C><S><E><N><A><A><Q><A><L><H><L><G><E><R><M><Q><E><A><K><K><L><L><G><S><L><Q><L><L><F><D><K><T><E><D><V><S><F><M><K><N><T><K><S><V><K><I><L><M><D><R><T><Q><T><C><T><S><S><S><L><S><P><T><K><I><G><H><L><N><S><K><L><F><L><N><E><V><A><K><K><E><K><Q><L><R><K><M><L><E><G><P><F><S><T><P><V><P><F><L><Q><S><V><P><L><Y><P><C><G><V><S><S><S><G><A><E><K><R><K><H><S><T><A><F><P><E><A><S><F><L><E><T><S><S><G><P><V><G><G><Q><Y><G><A><A><G><T><A><S><G><E><G><Q><S><G><Q><P><L><G><P><C><S><S><T><Q><H><L><V><A><L><P><G><G><A><Q><P><V><H><S><S><P><V><F><P><P><S><Q><Y><P><N><G><S><A><A><Q><Q><P><M><L><P><Q><Y><G><G><R><K><I><L><V><C><S><V><D><N><C><Y><C><S><S><V><A><N><H><G><G><H><Q><P><Y><P><R><S><G><H><F><P><W><T><V><P><S><Q><E><Y><S><H><P><L><P><P><T><P><S><V><P><Q><S><L><P><S><L><A><V><R><D><W><L><D><A><S><Q><Q><P><G><H><Q><D><F><Y><R><V><Y><G><Q><P><S><T><K><H><Y><V><T><S> | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response . Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 . Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B . Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus . Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction .<BOP> | Q9BZR9 |
O00634 | NET3_HUMAN | Netrin-2-like protein | Homo | <M><P><G><W><P><W><G><L><L><L><T><A><G><T><L><F><A><A><L><S><P><G><P><P><A><P><A><D><P><C><H><D><E><G><G><A><P><R><G><C><V><P><G><L><V><N><A><A><L><G><R><E><V><L><A><S><S><T><C><G><R><P><A><T><R><A><C><D><A><S><D><P><R><R><A><H><S><P><A><L><L><T><S><P><G><G><T><A><S><P><L><C><W><R><S><E><S><L><P><R><A><P><L><N><V><T><L><T><V><P><L><G><K><A><F><E><L><V><F><V><S><L><R><F><C><S><A><P><P><A><S><V><A><L><L><K><S><Q><D><H><G><R><S><W><A><P><L><G><F><F><S><S><H><C><D><L><D><Y><G><R><L><P><A><P><A><N><G><P><A><G><P><G><P><E><A><L><C><F><P><A><P><L><A><Q><P><D><G><S><G><L><L><A><F><S><M><Q><D><S><S><P><P><G><L><D><L><D><S><S><P><V><L><Q><D><W><V><T><A><T><D><V><R><V><V><L><T><R><P><S><T><A><G><D><P><R><D><M><E><A><V><V><P><Y><S><Y><A><A><T><D><L><Q><V><G><G><R><C><K><C><N><G><H><A><S><R><C><L><L><D><T><Q><G><H><L><I><C><D><C><R><H><G><T><E><G><P><D><C><G><R><C><K><P><F><Y><C><D><R><P><W><Q><R><A><T><A><R><E><S><H><A><C><L><A><C><S><C><N><G><H><A><R><R><C><R><F><N><M><E><L><Y><R><L><S><G><R><R><S><G><G><V><C><L><N><C><R><H><N><T><A><G><R><H><C><H><Y><C><R><E><G><F><Y><R><D><P><G><R><A><L><S><D><R><R><A><C><R><A><C><D><C><H><P><V><G><A><A><G><K><T><C><N><Q><T><T><G><Q><C><P><C><K><D><G><V><T><G><L><T><C><N><R><C><A><P><G><F><Q><Q><S><R><S><P><V><A><P><C><V><K><T><P><I><P><G><P><T><E><D><S><S><P><V><Q><P><Q><D><C><D><S><H><C><K><P><A><R><G><S><Y><R><I><S><L><K><K><F><C><K><K><D><Y><A><V><Q><V><A><V><G><A><R><G><E><A><R><G><A><W><T><R><F><P><V><A><V><L><A><V><F><R><S><G><E><E><R><A><R><R><G><S><S><A><L><W><V><P><A><G><D><A><A><C><G><C><P><R><L><L><P><G><R><R><Y><L><L><L><G><G><G><P><G><A><A><A><G><G><A><G><G><R><G><P><G><L><I><A><A><R><G><S><L><V><L><P><W><R><D><A><W><T><R><R><L><R><R><L><Q><R><R><E><R><R><G><R><C><S><A><A> | Netrins control guidance of CNS commissural axons and peripheral motor axons.<BOP> | O00634 |
O75715 | GPX5_HUMAN | Glutathione peroxidase 5 | Homo | <M><T><T><Q><L><R><V><V><H><L><L><P><L><L><L><A><C><F><V><Q><T><S><P><K><Q><E><K><M><K><M><D><C><H><K><D><E><K><G><T><I><Y><D><Y><E><A><I><A><L><N><K><N><E><Y><V><S><F><K><Q><Y><V><G><K><H><I><L><F><V><N><V><A><T><Y><C><G><L><T><A><Q><Y><P><E><L><N><A><L><Q><E><E><L><K><P><Y><G><L><V><V><L><G><F><P><C><N><Q><F><G><K><Q><E><P><G><D><N><K><E><I><L><P><G><L><K><Y><V><R><P><G><G><G><F><V><P><S><F><Q><L><F><E><K><G><D><V><N><G><E><K><E><Q><K><V><F><S><F><L><K><H><S><C><P><H><P><S><E><I><L><G><T><F><K><S><I><S><W><D><P><V><K><V><H><D><I><R><W><N><F><E><K><F><L><V><G><P><D><G><I><P><V><M><R><W><S><H><R><A><T><V><S><S><V><K><T><D><I><L><A><Y><L><K><Q><F><K><T><K> | Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.<BOP> | O75715 |
Q96LR5 | UB2E2_HUMAN | Ubiquitin-protein ligase E2 | Homo | <M><S><T><E><A><Q><R><V><D><D><S><P><S><T><S><G><G><S><S><D><G><D><Q><R><E><S><V><Q><Q><E><P><E><R><E><Q><V><Q><P><K><K><K><E><G><K><I><S><S><K><T><A><A><K><L><S><T><S><A><K><R><I><Q><K><E><L><A><E><I><T><L><D><P><P><P><N><C><S><A><G><P><K><G><D><N><I><Y><E><W><R><S><T><I><L><G><P><P><G><S><V><Y><E><G><G><V><F><F><L><D><I><T><F><S><P><D><Y><P><F><K><P><P><K><V><T><F><R><T><R><I><Y><H><C><N><I><N><S><Q><G><V><I><C><L><D><I><L><K><D><N><W><S><P><A><L><T><I><S><K><V><L><L><S><I><C><S><L><L><T><D><C><N><P><A><D><P><L><V><G><S><I><A><T><Q><Y><M><T><N><R><A><E><H><D><R><M><A><R><Q><W><T><K><R><Y><A><T> | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.<BOP> | Q96LR5 |
P78381 | S35A2_HUMAN | UDP-galactose transporter | Homo | <M><A><A><V><G><A><G><G><S><T><A><A><P><G><P><G><A><V><S><A><G><A><L><E><P><G><T><A><S><A><A><H><R><R><L><K><Y><I><S><L><A><V><L><V><V><Q><N><A><S><L><I><L><S><I><R><Y><A><R><T><L><P><G><D><R><F><F><A><T><T><A><V><V><M><A><E><V><L><K><G><L><T><C><L><L><L><L><F><A><Q><K><R><G><N><V><K><H><L><V><L><F><L><H><E><A><V><L><V><Q><Y><V><D><T><L><K><L><A><V><P><S><L><I><Y><T><L><Q><N><N><L><Q><Y><V><A><I><S><N><L><P><A><A><T><F><Q><V><T><Y><Q><L><K><I><L><T><T><A><L><F><S><V><L><M><L><N><R><S><L><S><R><L><Q><W><A><S><L><L><L><L><F><T><G><V><A><I><V><Q><A><Q><Q><A><G><G><G><G><P><R><P><L><D><Q><N><P><G><A><G><L><A><A><V><V><A><S><C><L><S><S><G><F><A><G><V><Y><F><E><K><I><L><K><G><S><S><G><S><V><W><L><R><N><L><Q><L><G><L><F><G><T><A><L><G><L><V><G><L><W><W><A><E><G><T><A><V><A><T><R><G><F><F><F><G><Y><T><P><A><V><W><G><V><V><L><N><Q><A><F><G><G><L><L><V><A><V><V><V><K><Y><A><D><N><I><L><K><G><F><A><T><S><L><S><I><V><L><S><T><V><A><S><I><R><L><F><G><F><H><V><D><P><L><F><A><L><G><A><G><L><V><I><G><A><V><Y><L><Y><S><L><P><R><G><A><A><K><A><I><A><S><A><S><A><S><A><S><G><P><C><V><H><Q><Q><P><P><G><Q><P><P><P><P><Q><L><S><S><H><R><G><D><L><I><T><E><P><F><L><P><K><L><L><T><K><V><K><G><S> | Transports uridine diphosphate galactose (UDP-galactose) from the cytosol into Golgi vesicles where glycosyltransferases function, including galactosyltransferases that catalyze globotriaosylceramide/globoside (Gb3Cer) synthesis from lactosylceramide.<BOP> | P78381 |
P49427 | UB2R1_HUMAN | Ubiquitin-protein ligase R1 | Homo | <M><A><R><P><L><V><P><S><S><Q><K><A><L><L><L><E><L><K><G><L><Q><E><E><P><V><E><G><F><R><V><T><L><V><D><E><G><D><L><Y><N><W><E><V><A><I><F><G><P><P><N><T><Y><Y><E><G><G><Y><F><K><A><R><L><K><F><P><I><D><Y><P><Y><S><P><P><A><F><R><F><L><T><K><M><W><H><P><N><I><Y><E><T><G><D><V><C><I><S><I><L><H><P><P><V><D><D><P><Q><S><G><E><L><P><S><E><R><W><N><P><T><Q><N><V><R><T><I><L><L><S><V><I><S><L><L><N><E><P><N><T><F><S><P><A><N><V><D><A><S><V><M><Y><R><K><W><K><E><S><K><G><K><D><R><E><Y><T><D><I><I><R><K><Q><V><L><G><T><K><V><D><A><E><R><D><G><V><K><V><P><T><T><L><A><E><Y><C><V><K><T><K><A><P><A><P><D><E><G><S><D><L><F><Y><D><D><Y><Y><E><D><G><E><V><E><E><E><A><D><S><C><F><G><D><D><E><D><D><S><G><T><E><E><S> | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination . Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the | P49427 |
Q9BYR0 | KRA47_HUMAN | Ultrahigh sulfur keratin-associated protein 4.7 | Homo | <M><V><S><S><C><C><G><S><V><C><S><D><Q><G><C><S><Q><D><L><C><Q><E><T><C><C><R><P><S><C><C><Q><T><T><C><C><R><T><T><C><Y><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><T><C><C><E><T><T><C><C><H><P><R><C><C><I><S><S><C><C><R><P><S><C><C><M><S><S><C><C><K><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><H><P><S><C><C><I><S><S><C><C><R><P><S><C><C><V><S><R><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><C><I><S><S><C><C><R><P><S><C><C><E><S><S><C><C><R><P><S><C><C><R><P><C><C><C><L><R><P><V><C><G><R><V><S><C><H><T><T><C><Y><R><P><T><C><V><I><S><T><C><P><R><P><L><C><C><A><S><S><C><C> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q9BYR0 |
C9JPN9 | UL17C_HUMAN | Ubiquitin carboxyl-terminal hydrolase 17-like protein 12 | Homo | <M><E><E><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><N><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y><M><L><S><R><E><H><S><Q><T><C><H><R><H><K><G><C><M><L><C><T><M><Q><A><H><I><T><R><A><L><H><N><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><A><H><E><F><L><M><F><T><V><D><A><M><K><K><A><C><L><P><G><H><K><Q><V><D><H><H><S><K><D><T><T><L><I><H><Q><I><F><G><G><Y><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><Q><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><V><C><L><Q><R><A><P><A><S><K><M><L><T><L><L><T><S><A><K><V><L><I><L><V><L><K><R><F><S><D><V><T><G><N><K><I><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><P><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><N><G><H><Y><F><S><Y><V><K><A><Q><E><G><Q><W><Y><K><M><D><D><A><E><V><T><A><S><S><I><T><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><A><E><D><T><D><R><R><A><T><Q><G><E><L><K><R><D><H><P><C><L><Q><A><P><E><L><D><E><H><L><V><E><R><A><T><Q><E><S><T><L><D><H><W><K><F><L><Q><E><Q><N><K><T><K><P><E><F><N><V><R><K><V><E><G><T><L><P><P><D><V><L><V><I><H><Q><S><K><Y><K><C><G><M><K><N><H><H><P><E><Q><Q><S><S><L><L><K><L><S><S><T><T><P><T><H><Q><E><S><M><N><T><G><T><L><A><S><L><R><G><R><A><R><R><S><K><G><K><N><K><H><S><K><R><A><L><L><V><C><Q> | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP> | C9JPN9 |
Q15617 | OR8G1_HUMAN | Olfactory receptor TPCR25 | Homo | <M><S><G><E><N><N><S><S><V><T><E><F><I><L><A><G><L><S><E><Q><P><E><L><Q><L><P><L><F><L><L><F><L><G><I><Y><V><V><T><V><V><G><N><L><G><M><T><T><L><I><W><L><S><S><H><L><H><T><P><M><Y><Y><F><L><S><S><L><S><F><I><D><F><C><H><S><T><V><I><T><P><K><M><L><V><N><F><V><T><E><K><N><I><I><S><Y><P><E><C><M><T><Q><L><Y><F><F><L><V><F><A><I><A><E><C><H><M><L><A><A><M><A><Y><D><R><Y><M><A><I><C><S><P><L><L><Y><S><V><I><I><S><N><K><A><C><F><S><L><I><L><G><V><Y><I><I><G><L><V><C><A><S><V><H><T><G><C><M><F><R><V><Q><F><C><K><F><D><L><I><N><H><Y><F><C><D><L><L><P><L><L><K><L><S><C><S><S><I><Y><V><N><K><L><L><I><L><C><V><G><A><F><N><I><L><V><P><S><L><T><I><L><C><S><Y><I><F><I><I><A><S><I><L><H><I><R><S><T><E><G><R><S><K><A><F><S><T><C><S><S><H><M><L><A><V><V><I><F><F><G><S><A><A><F><M><Y><L><Q><P><S><S><I><S><S><M><D><Q><G><K><V><S><S><V><F><Y><T><I><I><V><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><H><V><S><L><K><K><M><L><Q><R><R><T><L><L> | Odorant receptor.<BOP> | Q15617 |
Q8TAT2 | FGFP3_HUMAN | Fibroblast growth factor-binding protein 3 | Homo | <M><T><P><P><K><L><R><A><S><L><S><P><S><L><L><L><L><L><S><G><C><L><L><A><A><A><R><R><E><K><G><A><A><S><N><V><A><E><P><V><P><G><P><T><G><G><S><S><G><R><F><L><S><P><E><Q><H><A><C><S><W><Q><L><L><L><P><A><P><E><A><A><A><G><S><E><L><A><L><R><C><Q><S><P><D><G><A><R><H><Q><C><A><Y><R><G><H><P><E><R><C><A><A><Y><A><A><R><R><A><H><F><W><K><Q><V><L><G><G><L><R><K><K><R><R><P><C><H><D><P><A><P><L><Q><A><R><L><C><A><G><K><K><G><H><G><A><E><L><R><L><V><P><R><A><S><P><P><A><R><P><T><V><A><G><F><A><G><E><S><K><P><R><A><R><N><R><G><R><T><R><E><R><A><S><G><P><A><A><G><T><P><P><P><Q><S><A><P><P><K><E><N><P><S><E><R><K><T><N><E><G><K><R><K><A><A><L><V><P><N><E><E><R><P><M><G><T><G><P><D><P><D><G><L><D><G><N><A><E><L><T><E><T><Y><C><A><E><K><W><H><S><L><C><N><F><F><V><N><F><W><N><G> | Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.<BOP> | Q8TAT2 |
Q99572 | P2RX7_HUMAN | Purinergic receptor | Homo | <M><P><A><C><C><S><C><S><D><V><F><Q><Y><E><T><N><K><V><T><R><I><Q><S><M><N><Y><G><T><I><K><W><F><F><H><V><I><I><F><S><Y><V><C><F><A><L><V><S><D><K><L><Y><Q><R><K><E><P><V><I><S><S><V><H><T><K><V><K><G><I><A><E><V><K><E><E><I><V><E><N><G><V><K><K><L><V><H><S><V><F><D><T><A><D><Y><T><F><P><L><Q><G><N><S><F><F><V><M><T><N><F><L><K><T><E><G><Q><E><Q><R><L><C><P><E><Y><P><T><R><R><T><L><C><S><S><D><R><G><C><K><K><G><W><M><D><P><Q><S><K><G><I><Q><T><G><R><C><V><V><Y><E><G><N><Q><K><T><C><E><V><S><A><W><C><P><I><E><A><V><E><E><A><P><R><P><A><L><L><N><S><A><E><N><F><T><V><L><I><K><N><N><I><D><F><P><G><H><N><Y><T><T><R><N><I><L><P><G><L><N><I><T><C><T><F><H><K><T><Q><N><P><Q><C><P><I><F><R><L><G><D><I><F><R><E><T><G><D><N><F><S><D><V><A><I><Q><G><G><I><M><G><I><E><I><Y><W><D><C><N><L><D><R><W><F><H><H><C><R><P><K><Y><S><F><R><R><L><D><D><K><T><T><N><V><S><L><Y><P><G><Y><N><F><R><Y><A><K><Y><Y><K><E><N><N><V><E><K><R><T><L><I><K><V><F><G><I><R><F><D><I><L><V><F><G><T><G><G><K><F><D><I><I><Q><L><V><V><Y><I><G><S><T><L><S><Y><F><G><L><A><A><V><F><I><D><F><L><I><D><T><Y><S><S><N><C><C><R><S><H><I><Y><P><W><C><K><C><C><Q><P><C><V><V><N><E><Y><Y><Y><R><K><K><C><E><S><I><V><E><P><K><P><T><L><K><Y><V><S><F><V><D><E><S><H><I><R><M><V><N><Q><Q><L><L><G><R><S><L><Q><D><V><K><G><Q><E><V><P><R><P><A><M><D><F><T><D><L><S><R><L><P><L><A><L><H><D><T><P><P><I><P><G><Q><P><E><E><I><Q><L><L><R><K><E><A><T><P><R><S><R><D><S><P><V><W><C><Q><C><G><S><C><L><P><S><Q><L><P><E><S><H><R><C><L><E><E><L><C><C><R><K><K><P><G><A><C><I><T><T><S><E><L><F><R><K><L><V><L><S><R><H><V><L><Q><F><L><L><L><Y><Q><E><P><L><L><A><L><D><V><D><S><T><N><S><R><L><R><H><C><A><Y><R><C><Y><A><T><W><R><F><G><S><Q><D><M><A><D><F><A><I><L><P><S><C><C><R><W><R><I><R><K><E><F><P><K><S><E><G><Q><Y><S><G><F><K><S><P><Y> | Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells .<BOP> | Q99572 |
Q2M3X9 | ZN674_HUMAN | Zinc finger protein 674 | Homo | <M><A><M><S><Q><E><S><L><T><F><K><D><V><F><V><D><F><T><L><E><E><W><Q><Q><L><D><S><A><Q><K><N><L><Y><R><D><V><M><L><E><N><Y><S><H><L><V><S><V><G><H><L><V><G><K><P><D><V><I><F><R><L><G><P><G><D><E><S><W><M><A><D><G><G><T><P><V><R><T><C><A><G><E><D><R><P><E><V><W><E><V><D><E><Q><I><D><H><Y><K><E><S><Q><D><K><F><L><W><Q><A><A><F><I><G><K><E><T><L><K><D><E><S><G><Q><E><C><K><I><C><R><K><I><I><Y><L><N><T><D><F><V><S><V><K><Q><R><L><P><K><Y><Y><S><W><E><R><C><S><K><H><H><L><N><F><L><G><Q><N><R><S><Y><V><R><K><K><D><D><G><C><K><A><Y><W><K><V><C><L><H><Y><N><L><H><K><A><Q><P><A><E><R><F><F><D><P><N><Q><R><G><K><A><L><H><Q><K><Q><A><L><R><K><S><Q><R><S><Q><T><G><E><K><L><Y><K><C><T><E><C><G><K><V><F><I><Q><K><A><N><L><V><V><H><Q><R><T><H><T><G><E><K><P><Y><E><C><C><E><C><A><K><A><F><S><Q><K><S><T><L><I><A><H><Q><R><T><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><T><F><I><Q><K><S><T><L><I><K><H><Q><R><T><H><T><G><E><K><P><F><V><C><D><K><C><P><K><A><F><K><S><S><Y><H><L><I><R><H><E><K><T><H><I><R><Q><A><F><Y><K><G><I><K><C><T><T><S><S><L><I><Y><Q><R><I><H><T><S><E><K><P><Q><C><S><E><H><G><K><A><S><D><E><K><P><S><P><T><K><H><W><R><T><H><T><K><E><N><I><Y><E><C><S><K><C><G><K><S><F><R><G><K><S><H><L><S><V><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><I><C><G><K><T><F><S><G><K><S><H><L><S><V><H><H><R><T><H><T><G><E><K><P><Y><E><C><R><R><C><G><K><A><F><G><E><K><S><T><L><I><V><H><Q><R><M><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><S><E><K><S><P><L><I><K><H><Q><R><I><H><T><G><E><R><P><Y><E><C><T><D><C><K><K><A><F><S><R><K><S><T><L><I><K><H><Q><R><I><H><T><G><E><K><P><Y><K><C><S><E><C><G><K><A><F><S><V><K><S><T><L><I><V><H><H><R><T><H><T><G><E><K><P><Y><E><C><R><D><C><G><K><A><F><S><G><K><S><T><L><I><K><H><Q><R><S><H><T><G><D><K><N><L> | May be involved in transcriptional regulation.<BOP> | Q2M3X9 |
P36268 | GGT2_HUMAN | Inactive gamma-glutamyltranspeptidase 2 | Homo | <M><K><K><K><L><V><V><L><G><L><L><A><V><V><L><V><L><V><I><V><G><L><C><L><W><L><P><S><A><S><K><E><P><D><N><H><V><Y><T><R><A><A><M><A><A><D><A><K><Q><C><L><E><I><G><R><D><T><L><R><D><G><G><S><A><V><D><A><A><I><A><A><L><L><C><V><G><L><M><N><A><H><S><M><G><I><G><V><G><L><F><L><T><I><Y><N><S><T><T><G><K><A><E><V><I><N><A><R><E><V><A><P><R><L><A><F><A><S><M><F><N><S><S><E><Q><S><Q><K><G><G><L><S><V><A><V><P><G><E><I><R><G><Y><E><L><A><H><Q><R><H><G><R><L><P><W><A><R><L><F><Q><P><S><I><Q><L><A><R><Q><G><F><P><V><G><K><G><L><A><A><V><L><E><N><K><R><T><V><I><E><Q><Q><P><V><L><W><Y><V><F><C><R><D><R><K><V><L><R><E><G><E><R><L><T><L><P><R><L><A><D><T><Y><E><M><L><A><I><E><G><A><Q><A><F><Y><N><G><S><L><M><A><Q><I><V><K><D><I><Q><A><A><G><G><I><V><T><A><E><D><L><N><N><Y><R><A><E><L><I><E><H><P><L><N><I><S><L><G><D><A><V><L><Y><M><P><S><A><R><L><S><G><P><V><L><A><L><I><L><N><I><L><K><G><Y><N><F><S><R><E><S><V><E><T><P><E><Q><K><G><L><T><Y><H><R><I><V><E><A><F><R><F><A><Y><A><K><R><T><L><L><G><D><P><K><F><V><D><V><T><E><V><V><R><N><M><T><S><E><F><F><A><A><Q><L><R><S><Q><I><S><D><H><T><T><H><P><I><S><Y><Y><K><P><E><F><Y><T><P><D><D><G><G><T><A><H><L><S><V><V><A><E><D><G><S><A><V><S><A><T><S><T><I><N><L><Y><F><G><S><K><V><C><S><P><V><S><G><I><L><F><N><N><E><W><T><T><S><A><L><P><A><F><T><N><E><F><G><A><P><P><S><P><A><N><F><I><Q><P><G><K><Q><P><L><L><S><M><C><L><T><I><M><V><G><Q><D><G><Q><V><R><M><V><V><G><A><A><G><G><T><Q><I><T><T><D><T><A><L><A><I><I><Y><N><L><W><F><G><Y><D><V><K><R><A><V><E><E><P><R><L><H><N><K><L><L><P><N><V><T><T><V><E><R><N><I><D><Q><A><V><T><A><A><L><E><T><R><H><H><H><T><Q><I><A><S><T><F><I><A><V><V><Q><A><I><V><R><T><A><G><G><W><A><A><A><L><D><S><R><K><G><G><E><P><A><G><Y> | Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer.<BOP> | P36268 |
Q9H2F3 | 3BHS7_HUMAN | Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase | Homo | <M><A><D><S><A><Q><A><Q><K><L><V><Y><L><V><T><G><G><C><G><F><L><G><E><H><V><V><R><M><L><L><Q><R><E><P><R><L><G><E><L><R><V><F><D><Q><H><L><G><P><W><L><E><E><L><K><T><G><P><V><R><V><T><A><I><Q><G><D><V><T><Q><A><H><E><V><A><A><A><V><A><G><A><H><V><V><I><H><T><A><G><L><V><D><V><F><G><R><A><S><P><K><T><I><H><E><V><N><V><Q><G><T><R><N><V><I><E><A><C><V><Q><T><G><T><R><F><L><V><Y><T><S><S><M><E><V><V><G><P><N><T><K><G><H><P><F><Y><R><G><N><E><D><T><P><Y><E><A><V><H><R><H><P><Y><P><C><S><K><A><L><A><E><W><L><V><L><E><A><N><G><R><K><V><R><G><G><L><P><L><V><T><C><A><L><R><P><T><G><I><Y><G><E><G><H><Q><I><M><R><D><F><Y><R><Q><G><L><R><L><G><G><W><L><F><R><A><I><P><A><S><V><E><H><G><R><V><Y><V><G><N><V><A><W><M><H><V><L><A><A><R><E><L><E><Q><R><A><T><L><M><G><G><Q><V><Y><F><C><Y><D><G><S><P><Y><R><S><Y><E><D><F><N><M><E><F><L><G><P><C><G><L><R><L><V><G><A><R><P><L><L><P><Y><W><L><L><V><F><L><A><A><L><N><A><L><L><Q><W><L><L><R><P><L><V><L><Y><A><P><L><L><N><P><Y><T><L><A><V><A><N><T><T><F><T><V><S><T><D><K><A><Q><R><H><F><G><Y><E><P><L><F><S><W><E><D><S><R><T><R><T><I><L><W><V><Q><A><A><T><G><S><A><Q> | The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis . Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.<BOP> | Q9H2F3 |
A0A075B6K2 | LV312_HUMAN | Immunoglobulin lambda variable 3-12 | Homo | <M><A><W><T><P><L><L><L><S><L><L><A><H><C><T><G><S><A><T><S><Y><E><L><T><Q><P><H><S><V><S><V><A><T><A><Q><M><A><R><I><T><C><G><G><N><N><I><G><S><K><A><V><H><W><Y><Q><Q><K><P><G><Q><D><P><V><L><V><I><Y><S><D><S><N><R><P><S><G><I><P><E><R><F><S><G><S><N><P><G><N><T><A><T><L><T><I><S><R><I><E><A><G><D><E><A><D><Y><Y><C><Q><V><W><D><S><S><S><D><H> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A075B6K2 |
P10914 | IRF1_HUMAN | Interferon regulatory factor 1 | Homo | <M><P><I><T><R><M><R><M><R><P><W><L><E><M><Q><I><N><S><N><Q><I><P><G><L><I><W><I><N><K><E><E><M><I><F><Q><I><P><W><K><H><A><A><K><H><G><W><D><I><N><K><D><A><C><L><F><R><S><W><A><I><H><T><G><R><Y><K><A><G><E><K><E><P><D><P><K><T><W><K><A><N><F><R><C><A><M><N><S><L><P><D><I><E><E><V><K><D><Q><S><R><N><K><G><S><S><A><V><R><V><Y><R><M><L><P><P><L><T><K><N><Q><R><K><E><R><K><S><K><S><S><R><D><A><K><S><K><A><K><R><K><S><C><G><D><S><S><P><D><T><F><S><D><G><L><S><S><S><T><L><P><D><D><H><S><S><Y><T><V><P><G><Y><M><Q><D><L><E><V><E><Q><A><L><T><P><A><L><S><P><C><A><V><S><S><T><L><P><D><W><H><I><P><V><E><V><V><P><D><S><T><S><D><L><Y><N><F><Q><V><S><P><M><P><S><T><S><E><A><T><T><D><E><D><E><E><G><K><L><P><E><D><I><M><K><L><L><E><Q><S><E><W><Q><P><T><N><V><D><G><K><G><Y><L><L><N><E><P><G><V><Q><P><T><S><V><Y><G><D><F><S><C><K><E><E><P><E><I><D><S><P><G><G><D><I><G><L><S><L><Q><R><V><F><T><D><L><K><N><M><D><A><T><W><L><D><S><L><L><T><P><V><R><L><P><S><I><Q><A><I><P><C><A><P> | Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses . Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage . Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters . Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters . Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN | P10914 |
Q9NVR0 | KLH11_HUMAN | Kelch-like protein 11 | Homo | <M><A><A><A><A><V><A><A><A><A><A><A><A><A><A><A><S><L><Q><V><L><E><M><E><S><M><E><T><A><A><A><G><S><A><G><L><A><A><E><V><R><G><S><G><T><V><D><F><G><P><G><P><G><I><S><A><M><E><A><S><G><G><D><P><G><P><E><A><E><D><F><E><C><S><S><H><C><S><E><L><S><W><R><Q><N><E><Q><R><R><Q><G><L><F><C><D><I><T><L><C><F><G><G><A><G><G><R><E><F><R><A><H><R><S><V><L><A><A><A><T><E><Y><F><T><P><L><L><S><G><Q><F><S><E><S><R><S><G><R><V><E><M><R><K><W><S><S><E><P><G><P><E><P><D><T><V><E><A><V><I><E><Y><M><Y><T><G><R><I><R><V><S><T><G><S><V><H><E><V><L><E><L><A><D><R><F><L><L><I><R><L><K><E><F><C><G><E><F><L><K><K><K><L><H><L><S><N><C><V><A><I><H><S><L><A><H><M><Y><T><L><S><Q><L><A><L><K><A><A><D><M><I><R><R><N><F><H><K><V><I><Q><D><E><E><F><Y><T><L><P><F><H><L><I><R><D><W><L><S><D><L><E><I><T><V><D><S><E><E><V><L><F><E><T><V><L><K><W><V><Q><R><N><A><E><E><R><E><R><Y><F><E><E><L><F><K><L><L><R><L><S><Q><M><K><P><T><Y><L><T><R><H><V><K><P><E><R><L><V><A><N><N><E><V><C><V><K><L><V><A><D><A><V><E><R><H><A><L><R><A><E><N><I><Q><S><G><T><C><Q><H><P><T><S><H><V><S><L><L><P><R><Y><G><Q><N><M><D><V><I><M><V><I><G><G><V><S><E><G><G><D><Y><L><S><E><C><V><G><Y><F><V><D><E><D><R><W><V><N><L><P><H><I><H><N><H><L><D><G><H><A><V><A><V><T><E><S><Y><V><Y><V><A><G><S><M><E><P><G><F><A><K><T><V><E><R><Y><N><P><N><L><N><T><W><E><H><V><C><S><L><M><T><R><K><H><S><F><G><L><T><E><V><K><G><K><L><Y><S><I><G><G><H><G><N><F><S><P><G><F><K><D><V><T><V><Y><N><P><E><L><D><K><W><H><N><L><E><S><A><P><K><I><L><R><D><V><K><A><L><A><I><E><D><R><F><V><Y><I><A><A><R><T><P><V><D><R><D><T><E><D><G><L><K><A><V><I><T><C><Y><D><T><E><T><R><Q><W><Q><D><V><E><S><L><P><L><I><D><N><Y><C><F><F><Q><M><S><V><V><N><S><N><F><Y><Q><T><A><S><C><C><P><K><S><Y><C><L><E><N><E><E><A><V><R><K><I><A><S><Q><V><S><D><E><I><L><E><S><L><P><P><E><V><L><S><I><E><G><A><A><I><C><Y><Y><K><D><D><V><F><I><I><G><G><W><K><N><S><D><D><I><D><K><Q><Y><R><K><E><A><Y><R><Y><C><A><E><R><K><R><W><M><L><L><P><P><M><P><Q><P><R><C><R><A><T><A><C><H><V><R><I><P><Y><R><Y><L><H><G><T><Q><R><Y><P><M><P><Q><N><L><M><W><Q><K><D><R><I><R><Q><M><Q><E><I><H><R><H><A><L><N><M><R><R><V><P><S><S><Q><I><E><C> | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.<BOP> | Q9NVR0 |
P19801 | AOC1_HUMAN | Kidney amine oxidase | Homo | <M><P><A><L><G><W><A><V><A><A><I><L><M><L><Q><T><A><M><A><E><P><S><P><G><T><L><P><R><K><A><G><V><F><S><D><L><S><N><Q><E><L><K><A><V><H><S><F><L><W><S><K><K><E><L><R><L><Q><P><S><S><T><T><T><M><A><K><N><T><V><F><L><I><E><M><L><L><P><K><K><Y><H><V><L><R><F><L><D><K><G><E><R><H><P><V><R><E><A><R><A><V><I><F><F><G><D><Q><E><H><P><N><V><T><E><F><A><V><G><P><L><P><G><P><C><Y><M><R><A><L><S><P><R><P><G><Y><Q><S><S><W><A><S><R><P><I><S><T><A><E><Y><A><L><L><Y><H><T><L><Q><E><A><T><K><P><L><H><Q><F><F><L><N><T><T><G><F><S><F><Q><D><C><H><D><R><C><L><A><F><T><D><V><A><P><R><G><V><A><S><G><Q><R><R><S><W><L><I><I><Q><R><Y><V><E><G><Y><F><L><H><P><T><G><L><E><L><L><V><D><H><G><S><T><D><A><G><H><W><A><V><E><Q><V><W><Y><N><G><K><F><Y><G><S><P><E><E><L><A><R><K><Y><A><D><G><E><V><D><V><V><V><L><E><D><P><L><P><G><G><K><G><H><D><S><T><E><E><P><P><L><F><S><S><H><K><P><R><G><D><F><P><S><P><I><H><V><S><G><P><R><L><V><Q><P><H><G><P><R><F><R><L><E><G><N><A><V><L><Y><G><G><W><S><F><A><F><R><L><R><S><S><S><G><L><Q><V><L><N><V><H><F><G><G><E><R><I><A><Y><E><V><S><V><Q><E><A><V><A><L><Y><G><G><H><T><P><A><G><M><Q><T><K><Y><L><D><V><G><W><G><L><G><S><V><T><H><E><L><A><P><G><I><D><C><P><E><T><A><T><F><L><D><T><F><H><Y><Y><D><A><D><D><P><V><H><Y><P><R><A><L><C><L><F><E><M><P><T><G><V><P><L><R><R><H><F><N><S><N><F><K><G><G><F><N><F><Y><A><G><L><K><G><Q><V><L><V><L><R><T><T><S><T><V><Y><N><Y><D><Y><I><W><D><F><I><F><Y><P><N><G><V><M><E><A><K><M><H><A><T><G><Y><V><H><A><T><F><Y><T><P><E><G><L><R><H><G><T><R><L><H><T><H><L><I><G><N><I><H><T><H><L><V><H><Y><R><V><D><L><D><V><A><G><T><K><N><S><F><Q><T><L><Q><M><K><L><E><N><I><T><N><P><W><S><P><R><H><R><V><V><Q><P><T><L><E><Q><T><Q><Y><S><W><E><R><Q><A><A><F><R><F><K><R><K><L><P><K><Y><L><L><F><T><S><P><Q><E><N><P><W><G><H><K><R><T><Y><R><L><Q><I><H><S><M><A><D><Q><V><L><P><P><G><W><Q><E><E><Q><A><I><T><W><A><R><Y><P><L><A><V><T><K><Y><R><E><S><E><L><C><S><S><S><I><Y><H><Q><N><D><P><W><H><P><P><V><V><F><E><Q><F><L><H><N><N><E><N><I><E><N><E><D><L><V><A><W><V><T><V><G><F><L><H><I><P><H><S><E><D><I><P><N><T><A><T><P><G><N><S><V><G><F><L><L><R><P><F><N><F><F><P><E><D><P><S><L><A><S><R><D><T><V><I><V><W><P><R><D><N><G><P><N><Y><V><Q><R><W><I><P><E><D><R><D><C><S><M><P><P><P><F><S><Y><N><G><T><Y><R><P><V> | Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.<BOP> | P19801 |
Q8N9V2 | TRIML_HUMAN | Tripartite motif family-like protein 1 | Homo | <M><S><T><A><D><L><M><E><N><L><R><E><E><L><T><C><F><I><C><L><D><Y><F><S><S><P><V><T><T><E><C><G><H><S><F><C><L><V><C><L><L><R><S><W><E><E><H><N><T><P><L><S><C><P><E><C><W><R><T><L><E><G><P><H><F><Q><S><N><E><R><L><G><R><L><A><S><I><A><R><Q><L><R><S><Q><V><L><Q><S><E><D><E><Q><G><S><Y><G><R><M><P><T><T><A><K><A><L><S><D><D><E><Q><G><G><S><A><F><V><A><Q><S><H><G><A><N><R><V><H><L><S><S><E><A><E><E><H><H><R><E><K><L><Q><E><I><L><N><L><L><R><V><R><R><K><E><A><Q><A><V><L><T><H><E><K><E><R><V><K><L><C><Q><E><E><T><K><T><C><K><Q><V><V><V><S><E><Y><M><K><M><H><Q><F><L><K><E><E><E><Q><L><Q><L><Q><L><L><E><Q><E><E><K><E><N><M><R><K><L><R><N><N><E><I><K><L><T><Q><Q><I><R><S><L><S><K><M><I><A><Q><I><E><S><S><S><Q><S><S><A><F><E><S><L><E><E><V><R><G><A><L><E><R><S><E><P><L><L><L><Q><C><P><E><A><T><T><T><E><L><S><L><C><R><I><T><G><M><K><E><M><L><R><K><F><S><T><E><I><T><L><D><P><A><T><A><N><A><Y><L><V><L><S><E><D><L><K><S><V><K><Y><G><G><S><R><Q><Q><L><P><D><N><P><E><R><F><D><Q><S><A><T><V><L><G><T><Q><I><F><T><S><G><R><H><Y><W><E><V><E><V><G><N><K><T><E><W><E><V><G><I><C><K><D><S><V><S><R><K><G><N><L><P><K><P><P><G><D><L><F><S><L><I><G><L><K><I><G><D><D><Y><S><L><W><V><S><S><P><L><K><G><Q><H><V><R><E><P><V><C><K><V><G><V><F><L><D><Y><E><S><G><H><I><A><F><Y><N><G><T><D><E><S><L><I><Y><S><F><P><Q><A><S><F><Q><E><A><L><R><P><I><F><S><P><C><L><P><N><E><G><T><N><T><D><P><L><T><I><C><S><L><N><S><H><V> | Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.<BOP> | Q8N9V2 |
P14784 | IL2RB_HUMAN | p70-75 | Homo | <M><A><A><P><A><L><S><W><R><L><P><L><L><I><L><L><L><P><L><A><T><S><W><A><S><A><A><V><N><G><T><S><Q><F><T><C><F><Y><N><S><R><A><N><I><S><C><V><W><S><Q><D><G><A><L><Q><D><T><S><C><Q><V><H><A><W><P><D><R><R><R><W><N><Q><T><C><E><L><L><P><V><S><Q><A><S><W><A><C><N><L><I><L><G><A><P><D><S><Q><K><L><T><T><V><D><I><V><T><L><R><V><L><C><R><E><G><V><R><W><R><V><M><A><I><Q><D><F><K><P><F><E><N><L><R><L><M><A><P><I><S><L><Q><V><V><H><V><E><T><H><R><C><N><I><S><W><E><I><S><Q><A><S><H><Y><F><E><R><H><L><E><F><E><A><R><T><L><S><P><G><H><T><W><E><E><A><P><L><L><T><L><K><Q><K><Q><E><W><I><C><L><E><T><L><T><P><D><T><Q><Y><E><F><Q><V><R><V><K><P><L><Q><G><E><F><T><T><W><S><P><W><S><Q><P><L><A><F><R><T><K><P><A><A><L><G><K><D><T><I><P><W><L><G><H><L><L><V><G><L><S><G><A><F><G><F><I><I><L><V><Y><L><L><I><N><C><R><N><T><G><P><W><L><K><K><V><L><K><C><N><T><P><D><P><S><K><F><F><S><Q><L><S><S><E><H><G><G><D><V><Q><K><W><L><S><S><P><F><P><S><S><S><F><S><P><G><G><L><A><P><E><I><S><P><L><E><V><L><E><R><D><K><V><T><Q><L><L><L><Q><Q><D><K><V><P><E><P><A><S><L><S><S><N><H><S><L><T><S><C><F><T><N><Q><G><Y><F><F><F><H><L><P><D><A><L><E><I><E><A><C><Q><V><Y><F><T><Y><D><P><Y><S><E><E><D><P><D><E><G><V><A><G><A><P><T><G><S><S><P><Q><P><L><Q><P><L><S><G><E><D><D><A><Y><C><T><F><P><S><R><D><D><L><L><L><F><S><P><S><L><L><G><G><P><S><P><P><S><T><A><P><G><G><S><G><A><G><E><E><R><M><P><P><S><L><Q><E><R><V><P><R><D><W><D><P><Q><P><L><G><P><P><T><P><G><V><P><D><L><V><D><F><Q><P><P><P><E><L><V><L><R><E><A><G><E><E><V><P><D><A><G><P><R><E><G><V><S><F><P><W><S><R><P><P><G><Q><G><E><F><R><A><L><N><A><R><L><P><L><N><T><D><A><Y><L><S><L><Q><E><L><Q><G><Q><D><P><T><H><L><V> | Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 .<BOP> | P14784 |
P00748 | FA12_HUMAN | Beta-factor XIIa part 2 | Homo | <M><R><A><L><L><L><L><G><F><L><L><V><S><L><E><S><T><L><S><I><P><P><W><E><A><P><K><E><H><K><Y><K><A><E><E><H><T><V><V><L><T><V><T><G><E><P><C><H><F><P><F><Q><Y><H><R><Q><L><Y><H><K><C><T><H><K><G><R><P><G><P><Q><P><W><C><A><T><T><P><N><F><D><Q><D><Q><R><W><G><Y><C><L><E><P><K><K><V><K><D><H><C><S><K><H><S><P><C><Q><K><G><G><T><C><V><N><M><P><S><G><P><H><C><L><C><P><Q><H><L><T><G><N><H><C><Q><K><E><K><C><F><E><P><Q><L><L><R><F><F><H><K><N><E><I><W><Y><R><T><E><Q><A><A><V><A><R><C><Q><C><K><G><P><D><A><H><C><Q><R><L><A><S><Q><A><C><R><T><N><P><C><L><H><G><G><R><C><L><E><V><E><G><H><R><L><C><H><C><P><V><G><Y><T><G><A><F><C><D><V><D><T><K><A><S><C><Y><D><G><R><G><L><S><Y><R><G><L><A><R><T><T><L><S><G><A><P><C><Q><P><W><A><S><E><A><T><Y><R><N><V><T><A><E><Q><A><R><N><W><G><L><G><G><H><A><F><C><R><N><P><D><N><D><I><R><P><W><C><F><V><L><N><R><D><R><L><S><W><E><Y><C><D><L><A><Q><C><Q><T><P><T><Q><A><A><P><P><T><P><V><S><P><R><L><H><V><P><L><M><P><A><Q><P><A><P><P><K><P><Q><P><T><T><R><T><P><P><Q><S><Q><T><P><G><A><L><P><A><K><R><E><Q><P><P><S><L><T><R><N><G><P><L><S><C><G><Q><R><L><R><K><S><L><S><S><M><T><R><V><V><G><G><L><V><A><L><R><G><A><H><P><Y><I><A><A><L><Y><W><G><H><S><F><C><A><G><S><L><I><A><P><C><W><V><L><T><A><A><H><C><L><Q><D><R><P><A><P><E><D><L><T><V><V><L><G><Q><E><R><R><N><H><S><C><E><P><C><Q><T><L><A><V><R><S><Y><R><L><H><E><A><F><S><P><V><S><Y><Q><H><D><L><A><L><L><R><L><Q><E><D><A><D><G><S><C><A><L><L><S><P><Y><V><Q><P><V><C><L><P><S><G><A><A><R><P><S><E><T><T><L><C><Q><V><A><G><W><G><H><Q><F><E><G><A><E><E><Y><A><S><F><L><Q><E><A><Q><V><P><F><L><S><L><E><R><C><S><A><P><D><V><H><G><S><S><I><L><P><G><M><L><C><A><G><F><L><E><G><G><T><D><A><C><Q><G><D><S><G><G><P><L><V><C><E><D><Q><A><A><E><R><R><L><T><L><Q><G><I><I><S><W><G><S><G><C><G><D><R><N><K><P><G><V><Y><T><D><V><A><Y><Y><L><A><W><I><R><E><H><T><V><S> | Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.<BOP> | P00748 |
Q6UXV4 | MIC27_HUMAN | Protein FAM121A | Homo | <M><A><A><I><R><M><G><K><L><T><T><M><P><A><G><L><I><Y><A><S><V><S><V><H><A><A><K><Q><E><E><S><K><K><Q><L><V><K><P><E><Q><L><P><I><Y><T><A><P><P><L><Q><S><K><Y><V><E><E><Q><P><G><H><L><Q><M><G><F><A><S><I><R><T><A><T><G><C><Y><I><G><W><C><K><G><V><Y><V><F><V><K><N><G><I><M><D><T><V><Q><F><G><K><D><A><Y><V><Y><L><K><N><P><P><R><D><F><L><P><K><M><G><V><I><T><V><S><G><L><A><G><L><V><S><A><R><K><G><S><K><F><K><K><I><T><Y><P><L><G><L><A><T><L><G><A><T><V><C><Y><P><V><Q><S><V><I><I><A><K><V><T><A><K><K><V><Y><A><T><S><Q><Q><I><F><G><A><V><K><S><L><W><T><K><S><S><K><E><E><S><L><P><K><P><K><E><K><T><K><L><G><S><S><S><E><I><E><V><P><A><K><T><T><H><V><L><K><H><S><V><P><L><P><T><E><L><S><S><E><A><K><T><K><S><E><S><T><S><G><A><T><Q><F><M><P><D><P><K><L><M><D><H><G><Q><S><H><P><E><D><I><D><M><Y><S><T><R><S> | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function , .<BOP> | Q6UXV4 |
Q9UM44 | HHLA2_HUMAN | Human endogenous retrovirus-H long terminal repeat-associating protein 2 | Homo | <M><K><A><Q><T><A><L><S><F><F><L><I><L><I><T><S><L><S><G><S><Q><G><I><F><P><L><A><F><F><I><Y><V><P><M><N><E><Q><I><V><I><G><R><L><D><E><D><I><I><L><P><S><S><F><E><R><G><S><E><V><V><I><H><W><K><Y><Q><D><S><Y><K><V><H><S><Y><Y><K><G><S><D><H><L><E><S><Q><D><P><R><Y><A><N><R><T><S><L><F><Y><N><E><I><Q><N><G><N><A><S><L><F><F><R><R><V><S><L><L><D><E><G><I><Y><T><C><Y><V><G><T><A><I><Q><V><I><T><N><K><V><V><L><K><V><G><V><F><L><T><P><V><M><K><Y><E><K><R><N><T><N><S><F><L><I><C><S><V><L><S><V><Y><P><R><P><I><I><T><W><K><M><D><N><T><P><I><S><E><N><N><M><E><E><T><G><S><L><D><S><F><S><I><N><S><P><L><N><I><T><G><S><N><S><S><Y><E><C><T><I><E><N><S><L><L><K><Q><T><W><T><G><R><W><T><M><K><D><G><L><H><K><M><Q><S><E><H><V><S><L><S><C><Q><P><V><N><D><Y><F><S><P><N><Q><D><F><K><V><T><W><S><R><M><K><S><G><T><F><S><V><L><A><Y><Y><L><S><S><S><Q><N><T><I><I><N><E><S><R><F><S><W><N><K><E><L><I><N><Q><S><D><F><S><M><N><L><M><D><L><N><L><S><D><S><G><E><Y><L><C><N><I><S><S><D><E><Y><T><L><L><T><I><H><T><V><H><V><E><P><S><Q><E><T><A><S><H><N><K><G><L><W><I><L><V><P><S><A><I><L><A><A><F><L><L><I><W><S><V><K><C><C><R><A><Q><L><E><A><R><R><S><R><H><P><A><D><G><A><Q><Q><E><R><C><C><V><P><P><G><E><R><C><P><S><A><P><D><N><G><E><E><N><V><P><L><S><G><K><V> | Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.<BOP> | Q9UM44 |
O14657 | TOR1B_HUMAN | Torsin family 1 member B | Homo | <M><L><R><A><G><W><L><R><G><A><A><A><L><A><L><L><L><A><A><R><V><V><A><A><F><E><P><I><T><V><G><L><A><I><G><A><A><S><A><I><T><G><Y><L><S><Y><N><D><I><Y><C><R><F><A><E><C><C><R><E><E><R><P><L><N><A><S><A><L><K><L><D><L><E><E><K><L><F><G><Q><H><L><A><T><E><V><I><F><K><A><L><T><G><F><R><N><N><K><N><P><K><K><P><L><T><L><S><L><H><G><W><A><G><T><G><K><N><F><V><S><Q><I><V><A><E><N><L><H><P><K><G><L><K><S><N><F><V><H><L><F><V><S><T><L><H><F><P><H><E><Q><K><I><K><L><Y><Q><D><Q><L><Q><K><W><I><R><G><N><V><S><A><C><A><N><S><V><F><I><F><D><E><M><D><K><L><H><P><G><I><I><D><A><I><K><P><F><L><D><Y><Y><E><Q><V><D><G><V><S><Y><R><K><A><I><F><I><F><L><S><N><A><G><G><D><L><I><T><K><T><A><L><D><F><W><R><A><G><R><K><R><E><D><I><Q><L><K><D><L><E><P><V><L><S><V><G><V><F><N><N><K><H><S><G><L><W><H><S><G><L><I><D><K><N><L><I><D><Y><F><I><P><F><L><P><L><E><Y><R><H><V><K><M><C><V><R><A><E><M><R><A><R><G><S><A><I><D><E><D><I><V><T><R><V><A><E><E><M><T><F><F><P><R><D><E><K><I><Y><S><D><K><G><C><K><T><V><Q><S><R><L><D><F><H> | May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues.<BOP> | O14657 |
Q15389 | ANGP1_HUMAN | Angiopoietin-1 | Homo | <M><T><V><F><L><S><F><A><F><L><A><A><I><L><T><H><I><G><C><S><N><Q><R><R><S><P><E><N><S><G><R><R><Y><N><R><I><Q><H><G><Q><C><A><Y><T><F><I><L><P><E><H><D><G><N><C><R><E><S><T><T><D><Q><Y><N><T><N><A><L><Q><R><D><A><P><H><V><E><P><D><F><S><S><Q><K><L><Q><H><L><E><H><V><M><E><N><Y><T><Q><W><L><Q><K><L><E><N><Y><I><V><E><N><M><K><S><E><M><A><Q><I><Q><Q><N><A><V><Q><N><H><T><A><T><M><L><E><I><G><T><S><L><L><S><Q><T><A><E><Q><T><R><K><L><T><D><V><E><T><Q><V><L><N><Q><T><S><R><L><E><I><Q><L><L><E><N><S><L><S><T><Y><K><L><E><K><Q><L><L><Q><Q><T><N><E><I><L><K><I><H><E><K><N><S><L><L><E><H><K><I><L><E><M><E><G><K><H><K><E><E><L><D><T><L><K><E><E><K><E><N><L><Q><G><L><V><T><R><Q><T><Y><I><I><Q><E><L><E><K><Q><L><N><R><A><T><T><N><N><S><V><L><Q><K><Q><Q><L><E><L><M><D><T><V><H><N><L><V><N><L><C><T><K><E><G><V><L><L><K><G><G><K><R><E><E><E><K><P><F><R><D><C><A><D><V><Y><Q><A><G><F><N><K><S><G><I><Y><T><I><Y><I><N><N><M><P><E><P><K><K><V><F><C><N><M><D><V><N><G><G><G><W><T><V><I><Q><H><R><E><D><G><S><L><D><F><Q><R><G><W><K><E><Y><K><M><G><F><G><N><P><S><G><E><Y><W><L><G><N><E><F><I><F><A><I><T><S><Q><R><Q><Y><M><L><R><I><E><L><M><D><W><E><G><N><R><A><Y><S><Q><Y><D><R><F><H><I><G><N><E><K><Q><N><Y><R><L><Y><L><K><G><H><T><G><T><A><G><K><Q><S><S><L><I><L><H><G><A><D><F><S><T><K><D><A><D><N><D><N><C><M><C><K><C><A><L><M><L><T><G><G><W><W><F><D><A><C><G><P><S><N><L><N><G><M><F><Y><T><A><G><Q><N><H><G><K><L><N><G><I><K><W><H><Y><F><K><G><P><S><Y><S><L><R><S><T><T><M><M><I><R><P><L><D><F> | Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates | Q15389 |
Q9NPA8 | ENY2_HUMAN | Enhancer of yellow 2 transcription factor homolog | Homo | <M><V><V><S><K><M><N><K><D><A><Q><M><R><A><A><I><N><Q><K><L><I><E><T><G><E><R><E><R><L><K><E><L><L><R><A><K><L><I><E><C><G><W><K><D><Q><L><K><A><H><C><K><E><V><I><K><E><K><G><L><E><H><V><T><V><D><D><L><V><A><E><I><T><P><K><G><R><A><L><V><P><D><S><V><K><K><E><L><L><Q><R><I><R><T><F><L><A><Q><H><A><S><L> | Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation . As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores .<BOP> | Q9NPA8 |
P05543 | THBG_HUMAN | T4-binding globulin | Homo | <M><S><P><F><L><Y><L><V><L><L><V><L><G><L><H><A><T><I><H><C><A><S><P><E><G><K><V><T><A><C><H><S><S><Q><P><N><A><T><L><Y><K><M><S><S><I><N><A><D><F><A><F><N><L><Y><R><R><F><T><V><E><T><P><D><K><N><I><F><F><S><P><V><S><I><S><A><A><L><V><M><L><S><F><G><A><C><C><S><T><Q><T><E><I><V><E><T><L><G><F><N><L><T><D><T><P><M><V><E><I><Q><H><G><F><Q><H><L><I><C><S><L><N><F><P><K><K><E><L><E><L><Q><I><G><N><A><L><F><I><G><K><H><L><K><P><L><A><K><F><L><N><D><V><K><T><L><Y><E><T><E><V><F><S><T><D><F><S><N><I><S><A><A><K><Q><E><I><N><S><H><V><E><M><Q><T><K><G><K><V><V><G><L><I><Q><D><L><K><P><N><T><I><M><V><L><V><N><Y><I><H><F><K><A><Q><W><A><N><P><F><D><P><S><K><T><E><D><S><S><S><F><L><I><D><K><T><T><T><V><Q><V><P><M><M><H><Q><M><E><Q><Y><Y><H><L><V><D><M><E><L><N><C><T><V><L><Q><M><D><Y><S><K><N><A><L><A><L><F><V><L><P><K><E><G><Q><M><E><S><V><E><A><A><M><S><S><K><T><L><K><K><W><N><R><L><L><Q><K><G><W><V><D><L><F><V><P><K><F><S><I><S><A><T><Y><D><L><G><A><T><L><L><K><M><G><I><Q><H><A><Y><S><E><N><A><D><F><S><G><L><T><E><D><N><G><L><K><L><S><N><A><A><H><K><A><V><L><H><I><G><E><K><G><T><E><A><A><A><V><P><E><V><E><L><S><D><Q><P><E><N><T><F><L><H><P><I><I><Q><I><D><R><S><F><M><L><L><I><L><E><R><S><T><R><S><I><L><F><L><G><K><V><V><N><P><T><E><A> | Major thyroid hormone transport protein in serum.<BOP> | P05543 |
Q9BUB7 | TMM70_HUMAN | Transmembrane protein 70, mitochondrial | Homo | <M><L><F><L><A><L><G><S><P><W><A><V><E><L><P><L><C><G><R><R><T><A><L><C><A><A><A><A><L><R><G><P><R><A><S><V><S><R><A><S><S><S><S><G><P><S><G><P><V><A><G><W><S><T><G><P><S><G><A><A><R><L><L><R><R><P><G><R><A><Q><I><P><V><Y><W><E><G><Y><V><R><F><L><N><T><P><S><D><K><S><E><D><G><R><L><I><Y><T><G><N><M><A><R><A><V><F><G><V><K><C><F><S><Y><S><T><S><L><I><G><L><T><F><L><P><Y><I><F><T><Q><N><N><A><I><S><E><S><V><P><L><P><I><Q><I><I><F><Y><G><I><M><G><S><F><T><V><I><T><P><V><L><L><H><F><I><T><K><G><Y><V><I><R><L><Y><H><E><A><T><T><D><T><Y><K><A><I><T><Y><N><A><M><L><A><E><T><S><T><V><F><H><Q><N><D><V><K><I><P><D><A><K><H><V><F><T><T><F><Y><A><K><T><K><S><L><L><V><N><P><V><L><F><P><N><R><E><D><Y><I><H><L><M><G><Y><D><K><E><E><F><I><L><Y><M><E><E><T><S><E><E><K><R><H><K><D><D><K> | Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction . Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis . In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies .<BOP> | Q9BUB7 |
P31942 | HNRH3_HUMAN | Heterogeneous nuclear ribonucleoprotein 2H9 | Homo | <M><D><W><V><M><K><H><N><G><P><N><D><A><S><D><G><T><V><R><L><R><G><L><P><F><G><C><S><K><E><E><I><V><Q><F><F><Q><G><L><E><I><V><P><N><G><I><T><L><T><M><D><Y><Q><G><R><S><T><G><E><A><F><V><Q><F><A><S><K><E><I><A><E><N><A><L><G><K><H><K><E><R><I><G><H><R><Y><I><E><I><F><R><S><S><R><S><E><I><K><G><F><Y><D><P><P><R><R><L><L><G><Q><R><P><G><P><Y><D><R><P><I><G><G><R><G><G><Y><Y><G><A><G><R><G><S><M><Y><D><R><M><R><R><G><G><D><G><Y><D><G><G><Y><G><G><F><D><D><Y><G><G><Y><N><N><Y><G><Y><G><N><D><G><F><D><D><R><M><R><D><G><R><G><M><G><G><H><G><Y><G><G><A><G><D><A><S><S><G><F><H><G><G><H><F><V><H><M><R><G><L><P><F><R><A><T><E><N><D><I><A><N><F><F><S><P><L><N><P><I><R><V><H><I><D><I><G><A><D><G><R><A><T><G><E><A><D><V><E><F><V><T><H><E><D><A><V><A><A><M><S><K><D><K><N><N><M><Q><H><R><Y><I><E><L><F><L><N><S><T><P><G><G><G><S><G><M><G><G><S><G><M><G><G><Y><G><R><D><G><M><D><N><Q><G><G><Y><G><S><V><G><R><M><G><M><G><N><N><Y><S><G><G><Y><G><T><P><D><G><L><G><G><Y><G><R><G><G><G><G><S><G><G><Y><Y><G><Q><G><G><M><S><G><G><G><W><R><G><M><Y> | Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.<BOP> | P31942 |
Q9UK13 | ZN221_HUMAN | Zinc finger protein 221 | Homo | <M><I><S><P><S><L><E><L><L><H><S><G><L><C><K><F><P><E><V><E><G><K><M><T><T><F><K><E><A><V><T><F><K><D><V><A><V><V><F><T><E><E><E><L><G><L><L><D><P><A><Q><R><K><L><Y><R><D><V><M><L><E><N><F><R><N><L><L><S><V><G><N><Q><P><F><H><Q><D><T><F><H><F><L><G><K><E><K><F><W><K><M><K><T><T><S><Q><R><E><G><N><S><G><G><K><I><Q><I><E><M><E><T><V><P><E><A><G><P><H><E><E><W><S><C><Q><Q><I><W><E><Q><I><A><S><D><L><T><R><S><Q><N><S><I><R><N><S><S><Q><F><F><K><E><G><D><V><P><C><Q><I><E><A><R><L><S><I><S><H><V><Q><Q><K><P><Y><R><C><N><E><C><K><Q><S><F><S><D><V><S><V><F><D><L><H><Q><Q><S><H><S><G><E><K><S><H><T><C><G><E><C><G><K><S><F><C><Y><S><P><A><L><H><I><H><Q><R><V><H><M><G><E><K><C><Y><K><C><D><V><C><G><K><E><F><N><Q><S><S><H><L><Q><T><H><Q><R><V><H><T><G><E><K><P><F><K><C><G><Q><C><G><K><G><F><H><S><R><S><A><L><N><V><H><C><K><L><H><T><G><E><K><P><Y><N><C><E><E><C><G><K><A><F><I><H><D><S><Q><L><Q><E><H><Q><R><I><H><T><G><E><K><P><F><K><C><D><I><C><G><K><S><F><R><V><R><S><R><L><N><R><H><S><M><V><H><T><G><E><K><P><F><R><C><D><T><C><G><K><N><F><R><Q><R><S><A><L><N><S><H><S><M><V><H><I><E><E><K><P><Y><K><C><E><Q><C><G><K><G><F><I><C><R><R><D><F><C><K><H><Q><M><V><H><T><G><E><K><P><Y><N><C><K><E><C><G><K><T><F><R><W><S><S><C><L><L><N><H><Q><Q><V><H><S><G><Q><K><S><F><K><C><E><E><C><G><K><G><F><Y><T><N><S><R><R><S><S><H><Q><R><S><H><N><G><E><K><P><Y><N><C><E><E><C><G><K><D><Y><K><R><R><L><D><L><E><F><H><Q><R><V><H><T><G><E><R><P><Y><N><C><K><E><C><G><K><S><F><G><W><A><S><C><L><L><K><H><Q><R><L><H><S><G><E><K><P><F><K><C><E><E><C><G><K><R><F><T><Q><S><S><Q><L><H><S><H><Q><T><C><H><T><G><E><K><L><Y><K><C><E><Q><C><E><K><G><Y><N><S><K><F><N><L><D><M><H><Q><R><V><H><G><G><E><R><P><Y><N><C><K><E><C><G><K><S><F><G><W><A><S><C><L><L><K><H><Q><R><L><H><S><G><E><K><P><L><K><S><G><V><W><E><E><I><Y><S><E><F><T><A><S><F><T><S><V><S><L><C><G><R><K><A><I> | May be involved in transcriptional regulation.<BOP> | Q9UK13 |
Q96E09 | PBIR1_HUMAN | PABIR family member 1 | Homo | <M><A><Q><E><K><M><E><L><D><L><E><L><P><P><G><T><G><G><S><P><A><E><G><G><G><S><G><G><G><G><G><L><R><R><S><N><S><A><P><L><I><H><G><L><S><D><T><S><P><V><F><Q><A><E><A><P><S><A><R><R><N><S><T><T><F><P><S><R><H><G><L><L><L><P><A><S><P><V><R><M><H><S><S><R><L><H><Q><I><K><Q><E><E><G><M><D><L><I><N><R><E><T><V><H><E><R><E><V><Q><T><A><M><Q><I><S><H><S><W><E><E><S><F><S><L><S><D><N><D><V><E><K><S><A><S><P><K><R><I><D><F><I><P><V><S><P><A><P><S><P><T><R><G><I><G><K><Q><C><F><S><P><S><L><Q><S><F><V><S><S><N><G><L><P><P><S><P><I><P><S><P><T><T><R><F><T><T><R><R><S><Q><S><P><I><N><C><I><R><P><S><V><L><G><P><L><K><R><K><C><E><M><E><T><E><Y><Q><P><K><R><F><F><Q><G><I><T><N><M><L><S><S><D><V><A><Q><L><S><D><P><G><V><C><V><S><S><D><T><L><D><G><N><S><S><S><A><G><S><S><C><N><S><P><A><K><V><S><T><T><T><D><S><P><V><S><P><A><Q><A><A><S><P><F><I><P><L><D><E><L><S><S><K> | Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity . Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) . Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint .<BOP> | Q96E09 |
Q16891 | MIC60_HUMAN | p87/89 | Homo | <M><L><R><A><C><Q><L><S><G><V><T><A><A><A><Q><S><C><L><C><G><K><F><V><L><R><P><L><R><P><C><R><R><Y><S><T><S><G><S><S><G><L><T><T><G><K><I><A><G><A><G><L><L><F><V><G><G><G><I><G><G><T><I><L><Y><A><K><W><D><S><H><F><R><E><S><V><E><K><T><I><P><Y><S><D><K><L><F><E><M><V><L><G><P><A><A><Y><N><V><P><L><P><K><K><S><I><Q><S><G><P><L><K><I><S><S><V><S><E><V><M><K><E><S><K><Q><P><A><S><Q><L><Q><K><Q><K><G><D><T><P><A><S><A><T><A><P><T><E><A><A><Q><I><I><S><A><A><G><D><T><L><S><V><P><A><P><A><V><Q><P><E><E><S><L><K><T><D><H><P><E><I><G><E><G><K><P><T><P><A><L><S><E><E><A><S><S><S><S><I><R><E><R><P><P><E><E><V><A><A><R><L><A><Q><Q><E><K><Q><E><Q><V><K><I><E><S><L><A><K><S><L><E><D><A><L><R><Q><T><A><S><V><T><L><Q><A><I><A><A><Q><N><A><A><V><Q><A><V><N><A><H><S><N><I><L><K><A><A><M><D><N><S><E><I><A><G><E><K><K><S><A><Q><W><R><T><V><E><G><A><L><K><E><R><R><K><A><V><D><E><A><A><D><A><L><L><K><A><K><E><E><L><E><K><M><K><S><V><I><E><N><A><K><K><K><E><V><A><G><A><K><P><H><I><T><A><A><E><G><K><L><H><N><M><I><V><D><L><D><N><V><V><K><K><V><Q><A><A><Q><S><E><A><K><V><V><S><Q><Y><H><E><L><V><V><Q><A><R><D><D><F><K><R><E><L><D><S><I><T><P><E><V><L><P><G><W><K><G><M><S><V><S><D><L><A><D><K><L><S><T><D><D><L><N><S><L><I><A><H><A><H><R><R><I><D><Q><L><N><R><E><L><A><E><Q><K><A><T><E><K><Q><H><I><T><L><A><L><E><K><Q><K><L><E><E><K><R><A><F><D><S><A><V><A><K><A><L><E><H><H><R><S><E><I><Q><A><E><Q><D><R><K><I><E><E><V><R><D><A><M><E><N><E><M><R><T><Q><L><R><R><Q><A><A><A><H><T><D><H><L><R><D><V><L><R><V><Q><E><Q><E><L><K><S><E><F><E><Q><N><L><S><E><K><L><S><E><Q><E><L><Q><F><R><R><L><S><Q><E><Q><V><D><N><F><T><L><D><I><N><T><A><Y><A><R><L><R><G><I><E><Q><A><V><Q><S><H><A><V><A><E><E><E><A><R><K><A><H><Q><L><W><L><S><V><E><A><L><K><Y><S><M><K><T><S><S><A><E><T><P><T><I><P><L><G><S><A><V><E><A><I><K><A><N><C><S><D><N><E><F><T><Q><A><L><T><A><A><I><P><P><E><S><L><T><R><G><V><Y><S><E><E><T><L><R><A><R><F><Y><A><V><Q><K><L><A><R><R><V><A><M><I><D><E><T><R><N><S><L><Y><Q><Y><F><L><S><Y><L><Q><S><L><L><L><F><P><P><Q><Q><L><K><P><P><P><E><L><C><P><E><D><I><N><T><F><K><L><L><S><Y><A><S><Y><C><I><E><H><G><D><L><E><L><A><A><K><F><V><N><Q><L><K><G><E><S><R><R><V><A><Q><D><W><L><K><E><A><R><M><T><L><E><T><K><Q><I><V><E><I><L><T><A><Y><A><S><A><V><G><I><G><T><T><Q><V><Q><P><E> | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology .<BOP> | Q16891 |
O14977 | AZIN1_HUMAN | Ornithine decarboxylase antizyme inhibitor | Homo | <M><K><G><F><I><D><D><A><N><Y><S><V><G><L><L><D><E><G><T><N><L><G><N><V><I><D><N><Y><V><Y><E><H><T><L><T><G><K><N><A><F><F><V><G><D><L><G><K><I><V><K><K><H><S><Q><W><Q><N><V><V><A><Q><I><K><P><F><Y><T><V><K><C><N><S><A><P><A><V><L><E><I><L><A><A><L><G><T><G><F><A><C><S><S><K><N><E><M><A><L><V><Q><E><L><G><V><P><P><E><N><I><I><Y><I><S><P><C><K><Q><V><S><Q><I><K><Y><A><A><K><V><G><V><N><I><L><T><C><D><N><E><I><E><L><K><K><I><A><R><N><H><P><N><A><K><V><L><L><H><I><A><T><E><D><N><I><G><G><E><E><G><N><M><K><F><G><T><T><L><K><N><C><R><H><L><L><E><C><A><K><E><L><D><V><Q><I><I><G><V><K><F><H><V><S><S><A><C><K><E><S><Q><V><Y><V><H><A><L><S><D><A><R><C><V><F><D><M><A><G><E><I><G><F><T><M><N><M><L><D><I><G><G><G><F><T><G><T><E><F><Q><L><E><E><V><N><H><V><I><S><P><L><L><D><I><Y><F><P><E><G><S><G><V><K><I><I><S><E><P><G><S><Y><Y><V><S><S><A><F><T><L><A><V><N><I><I><A><K><K><V><V><E><N><D><K><F><P><S><G><V><E><K><T><G><S><D><E><P><A><F><M><Y><Y><M><N><D><G><V><Y><G><S><F><A><S><K><L><S><E><D><L><N><T><I><P><E><V><H><K><K><Y><K><E><D><E><P><L><F><T><S><S><L><W><G><P><S><C><D><E><L><D><Q><I><V><E><S><C><L><L><P><E><L><N><V><G><D><W><L><I><F><D><N><M><G><A><D><S><F><H><E><P><S><A><F><N><D><F><Q><R><P><A><I><Y><Y><M><M><S><F><S><D><W><Y><E><M><Q><D><A><G><I><T><S><D><S><M><M><K><N><F><F><F><V><P><S><C><I><Q><L><S><Q><E><D><S><F><S><A><E><A> | Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding . Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production .<BOP> | O14977 |
Q8N6C8 | LIRA3_HUMAN | Monocyte inhibitory receptor HM43/HM31 | Homo | <M><T><P><I><L><T><V><L><I><C><L><G><L><S><L><D><P><R><T><H><V><Q><A><G><P><L><P><K><P><T><L><W><A><E><P><G><S><V><I><T><Q><G><S><P><V><T><L><R><C><Q><G><S><L><E><T><Q><E><Y><H><L><Y><R><E><K><K><T><A><L><W><I><T><R><I><P><Q><E><L><V><K><K><G><Q><F><P><I><L><S><I><T><W><E><H><A><G><R><Y><C><C><I><Y><G><S><H><T><A><G><L><S><E><S><S><D><P><L><E><L><V><V><T><G><A><Y><S><K><P><T><L><S><A><L><P><S><P><V><V><T><S><G><G><N><V><T><I><Q><C><D><S><Q><V><A><F><D><G><F><I><L><C><K><E><G><E><D><E><H><P><Q><C><L><N><S><H><S><H><A><R><G><S><S><R><A><I><F><S><V><G><P><V><S><P><S><R><R><W><S><Y><R><C><Y><G><Y><D><S><R><A><P><Y><V><W><S><L><P><S><D><L><L><G><L><L><V><P><G><V><S><K><K><P><S><L><S><V><Q><P><G><P><V><V><A><P><G><E><K><L><T><F><Q><C><G><S><D><A><G><Y><D><R><F><V><L><Y><K><E><W><G><R><D><F><L><Q><R><P><G><R><Q><P><Q><A><G><L><S><Q><A><N><F><T><L><G><P><V><S><R><S><Y><G><G><Q><Y><T><C><S><G><A><Y><N><L><S><S><E><W><S><A><P><S><D><P><L><D><I><L><I><T><G><Q><I><R><A><R><P><F><L><S><V><R><P><G><P><T><V><A><S><G><E><N><V><T><L><L><C><Q><S><Q><G><G><M><H><T><F><L><L><T><K><E><G><A><A><D><S><P><L><R><L><K><S><K><R><Q><S><H><K><Y><Q><A><E><F><P><M><S><P><V><T><S><A><H><A><G><T><Y><R><C><Y><G><S><L><S><S><N><P><Y><L><L><T><H><P><S><D><P><L><E><L><V><V><S><G><A><A><E><T><L><S><P><P><Q><N><K><S><D><S><K><A><G><E> | Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.<BOP> | Q8N6C8 |
P14854 | CX6B1_HUMAN | Cytochrome c oxidase subunit VIb isoform 1 | Homo | <M><A><E><D><M><E><T><K><I><K><N><Y><K><T><A><P><F><D><S><R><F><P><N><Q><N><Q><T><R><N><C><W><Q><N><Y><L><D><F><H><R><C><Q><K><A><M><T><A><K><G><G><D><I><S><V><C><E><W><Y><Q><R><V><Y><Q><S><L><C><P><T><S><W><V><T><D><W><D><E><Q><R><A><E><G><T><F><P><G><K><I> | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from | P14854 |
Q8TC92 | ENOX1_HUMAN | Protein disulfide-thiol oxidoreductase | Homo | <M><V><D><A><G><G><V><E><N><I><T><Q><L><P><Q><E><L><P><Q><M><M><A><A><A><A><D><G><L><G><S><I><A><I><D><T><T><Q><L><N><M><S><V><T><D><P><T><A><W><A><T><A><M><N><N><L><G><M><V><P><V><G><L><P><G><Q><Q><L><V><S><D><S><I><C><V><P><G><F><D><P><S><L><N><M><M><T><G><I><T><P><I><N><P><M><I><P><G><L><G><L><V><P><P><P><P><P><T><E><V><A><V><V><K><E><I><I><H><C><K><S><C><T><L><F><P><Q><N><P><N><L><P><P><P><S><T><R><E><R><P><P><G><C><K><T><V><F><V><G><G><L><P><E><N><A><T><E><E><I><I><Q><E><V><F><E><Q><C><G><D><I><T><A><I><R><K><S><K><K><N><F><C><H><I><R><F><A><E><E><F><M><V><D><K><A><I><Y><L><S><G><Y><R><M><R><L><G><S><S><T><D><K><K><D><S><G><R><L><H><V><D><F><A><Q><A><R><D><D><F><Y><E><W><E><C><K><Q><R><M><R><A><R><E><E><R><H><R><R><K><L><E><E><D><R><L><R><P><P><S><P><P><A><I><M><H><Y><S><E><H><E><A><A><L><L><A><E><K><L><K><D><D><S><K><F><S><E><A><I><T><V><L><L><S><W><I><E><R><G><E><V><N><R><R><S><A><N><Q><F><Y><S><M><V><Q><S><A><N><S><H><V><R><R><L><M><N><E><K><A><T><H><E><Q><E><M><E><E><A><K><E><N><F><K><N><A><L><T><G><I><L><T><Q><F><E><Q><I><V><A><V><F><N><A><S><T><R><Q><K><A><W><D><H><F><S><K><A><Q><R><K><N><I><D><I><W><R><K><H><S><E><E><L><R><N><A><Q><S><E><Q><L><M><G><I><R><R><E><E><E><M><E><M><S><D><D><E><N><C><D><S><P><T><K><K><M><R><V><D><E><S><A><L><A><A><Q><A><Y><A><L><K><E><E><N><D><S><L><R><W><Q><L><D><A><Y><R><N><E><V><E><L><L><K><Q><E><K><E><Q><L><F><R><T><E><E><N><L><T><K><D><Q><Q><L><Q><F><L><Q><Q><T><M><Q><G><M><Q><Q><Q><L><L><T><I><Q><E><E><L><N><N><K><K><S><E><L><E><Q><A><K><E><E><Q><S><H><T><Q><A><L><L><K><V><L><Q><E><Q><L><K><G><T><K><E><L><V><E><T><N><G><H><S><H><E><D><S><N><E><I><N><V><L><T><V><A><L><V><N><Q><D><R><E><N><N><I><E><K><R><S><Q><G><L><K><S><E><K><E><A><L><L><I><G><I><I><S><T><F><L><H><V><H><P><F><G><A><N><I><E><Y><L><W><S><Y><M><Q><Q><L><D><S><K><I><S><A><N><E><I><E><M><L><L><M><R><L><P><R><M><F><K><Q><E><F><T><G><V><G><A><T><L><E><K><R><W><K><L><C><A><F><E><G><I><K><T><T> | Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.<BOP> | Q8TC92 |
Q8TCT7 | SPP2B_HUMAN | Presenilin-like protein 1 | Homo | <M><A><A><A><V><A><A><A><L><A><R><L><L><A><A><F><L><L><L><A><A><Q><V><A><C><E><Y><G><M><V><H><V><V><S><Q><A><G><G><P><E><G><K><D><Y><C><I><L><Y><N><P><Q><W><A><H><L><P><H><D><L><S><K><A><S><F><L><Q><L><R><N><W><T><A><S><L><L><C><S><A><A><D><L><P><A><R><G><F><S><N><Q><I><P><L><V><A><R><G><N><C><T><F><Y><E><K><V><R><L><A><Q><G><S><G><A><R><G><L><L><I><V><S><R><E><R><L><V><P><P><G><G><N><K><T><Q><Y><D><E><I><G><I><P><V><A><L><L><S><Y><K><D><M><L><D><I><F><T><R><F><G><R><T><V><R><A><A><L><Y><A><P><K><E><P><V><L><D><Y><N><M><V><I><I><F><I><M><A><V><G><T><V><A><I><G><G><Y><W><A><G><S><R><D><V><K><K><R><Y><M><K><H><K><R><D><D><G><P><E><K><Q><E><D><E><A><V><D><V><T><P><V><M><T><C><V><F><V><V><M><C><C><S><M><L><V><L><L><Y><Y><F><Y><D><L><L><V><Y><V><V><I><G><I><F><C><L><A><S><A><T><G><L><Y><S><C><L><A><P><C><V><R><R><L><P><F><G><K><C><R><I><P><N><N><S><L><P><Y><F><H><K><R><P><Q><A><R><M><L><L><L><A><L><F><C><V><A><V><S><V><V><W><G><V><F><R><N><E><D><Q><W><A><W><V><L><Q><D><A><L><G><I><A><F><C><L><Y><M><L><K><T><I><R><L><P><T><F><K><A><C><T><L><L><L><L><V><L><F><L><Y><D><I><F><F><V><F><I><T><P><F><L><T><K><S><G><S><S><I><M><V><E><V><A><T><G><P><S><D><S><A><T><R><E><K><L><P><M><V><L><K><V><P><R><L><N><S><S><P><L><A><L><C><D><R><P><F><S><L><L><G><F><G><D><I><L><V><P><G><L><L><V><A><Y><C><H><R><F><D><I><Q><V><Q><S><S><R><V><Y><F><V><A><C><T><I><A><Y><G><V><G><L><L><V><T><F><V><A><L><A><L><M><Q><R><G><Q><P><A><L><L><Y><L><V><P><C><T><L><V><T><S><C><A><V><A><L><W><R><R><E><L><G><V><F><W><T><G><S><G><F><A><K><V><L><P><P><S><P><W><A><P><A><P><A><D><G><P><Q><P><P><K><D><S><A><T><P><L><S><P><Q><P><P><S><E><E><P><A><T><S><P><W><P><A><E><Q><S><P><K><S><R><T><S><E><E><M><G><A><G><A><P><M><R><E><P><G><S><P><A><E><S><E><G><R><D><Q><A><Q><P><S><P><V><T><Q><P><G><A><S><A> | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing . Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus . May play a role in the regulation of innate and adaptive immunity . Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis .<BOP> | Q8TCT7 |
Q8NHW3 | MAFA_HUMAN | V-maf musculoaponeurotic fibrosarcoma oncogene homolog A | Homo | <M><A><A><E><L><A><M><G><A><E><L><P><S><S><P><L><A><I><E><Y><V><N><D><F><D><L><M><K><F><E><V><K><K><E><P><P><E><A><E><R><F><C><H><R><L><P><P><G><S><L><S><S><T><P><L><S><T><P><C><S><S><V><P><S><S><P><S><F><C><A><P><S><P><G><T><G><G><G><G><G><A><G><G><G><G><G><S><S><Q><A><G><G><A><P><G><P><P><S><G><G><P><G><A><V><G><G><T><S><G><K><P><A><L><E><D><L><Y><W><M><S><G><Y><Q><H><H><L><N><P><E><A><L><N><L><T><P><E><D><A><V><E><A><L><I><G><S><G><H><H><G><A><H><H><G><A><H><H><P><A><A><A><A><A><Y><E><A><F><R><G><P><G><F><A><G><G><G><G><A><D><D><M><G><A><G><H><H><H><G><A><H><H><A><A><H><H><H><H><A><A><H><H><H><H><H><H><H><H><H><H><G><G><A><G><H><G><G><G><A><G><H><H><V><R><L><E><E><R><F><S><D><D><Q><L><V><S><M><S><V><R><E><L><N><R><Q><L><R><G><F><S><K><E><E><V><I><R><L><K><Q><K><R><R><T><L><K><N><R><G><Y><A><Q><S><C><R><F><K><R><V><Q><Q><R><H><I><L><E><S><E><K><C><Q><L><Q><S><Q><V><E><Q><L><K><L><E><V><G><R><L><A><K><E><R><D><L><Y><K><E><K><Y><E><K><L><A><G><R><G><G><P><G><S><A><G><G><A><G><F><P><R><E><P><S><P><P><Q><A><G><P><G><G><A><K><G><T><A><D><F><F><L> | Transcription factor that activates insulin gene expression . Acts synergistically with NEUROD1/BETA2 and PDX1 . Binds the insulin enhancer C1/RIPE3b element . Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence .<BOP> | Q8NHW3 |
P60763 | RAC3_HUMAN | p21-Rac3 | Homo | <M><Q><A><I><K><C><V><V><V><G><D><G><A><V><G><K><T><C><L><L><I><S><Y><T><T><N><A><F><P><G><E><Y><I><P><T><V><F><D><N><Y><S><A><N><V><M><V><D><G><K><P><V><N><L><G><L><W><D><T><A><G><Q><E><D><Y><D><R><L><R><P><L><S><Y><P><Q><T><D><V><F><L><I><C><F><S><L><V><S><P><A><S><F><E><N><V><R><A><K><W><Y><P><E><V><R><H><H><C><P><H><T><P><I><L><L><V><G><T><K><L><D><L><R><D><D><K><D><T><I><E><R><L><R><D><K><K><L><A><P><I><T><Y><P><Q><G><L><A><M><A><R><E><I><G><S><V><K><Y><L><E><C><S><A><L><T><Q><R><G><L><K><T><V><F><D><E><A><I><R><A><V><L><C><P><P><P><V><K><K><P><G><K><K><C><T><V><F> | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.<BOP> | P60763 |
Q5VV17 | OTUD1_HUMAN | DUBA-7 | Homo | <M><Q><L><Y><S><S><V><C><T><H><Y><P><A><G><A><P><G><P><T><A><A><A><P><A><P><P><A><A><A><T><P><F><K><V><S><L><Q><P><P><G><A><A><G><A><A><P><E><P><E><T><G><E><C><Q><P><A><A><A><A><E><H><R><E><A><A><A><V><P><A><A><K><M><P><A><F><S><S><C><F><E><V><V><S><G><A><A><A><P><A><S><A><A><A><G><P><P><G><A><S><C><K><P><P><L><P><P><H><Y><T><S><T><A><Q><I><T><V><R><A><L><G><A><D><R><L><L><L><H><G><P><D><P><V><P><G><A><A><G><S><A><A><A><P><R><G><R><C><L><L><L><A><P><A><P><A><A><P><V><P><P><R><R><G><S><S><A><W><L><L><E><E><L><L><R><P><D><C><P><E><P><A><G><L><D><A><T><R><E><G><P><D><R><N><F><R><L><S><E><H><R><Q><A><L><A><A><A><K><H><R><G><P><A><A><T><P><G><S><P><D><P><G><P><G><P><W><G><E><E><H><L><A><E><R><G><P><R><G><W><E><R><G><G><D><R><C><D><A><P><G><G><D><A><A><R><R><P><D><P><E><A><E><A><P><P><A><G><S><I><E><A><A><P><S><S><A><A><E><P><V><I><V><S><R><S><D><P><R><D><E><K><L><A><L><Y><L><A><E><V><E><K><Q><D><K><Y><L><R><Q><R><N><K><Y><R><F><H><I><I><P><D><G><N><C><L><Y><R><A><V><S><K><T><V><Y><G><D><Q><S><L><H><R><E><L><R><E><Q><T><V><H><Y><I><A><D><H><L><D><H><F><S><P><L><I><E><G><D><V><G><E><F><I><I><A><A><A><Q><D><G><A><W><A><G><Y><P><E><L><L><A><M><G><Q><M><L><N><V><N><I><H><L><T><T><G><G><R><L><E><S><P><T><V><S><T><M><I><H><Y><L><G><P><E><D><S><L><R><P><S><I><W><L><S><W><L><S><N><G><H><Y><D><A><V><F><D><H><S><Y><P><N><P><E><Y><D><N><W><C><K><Q><T><Q><V><Q><R><K><R><D><E><E><L><A><K><S><M><A><I><S><L><S><K><M><Y><I><E><Q><N><A><C><S> | Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.<BOP> | Q5VV17 |
Q32M78 | ZN699_HUMAN | Hangover homolog | Homo | <M><E><E><E><R><K><T><A><E><L><Q><K><N><R><I><Q><D><S><V><V><F><E><D><V><A><V><D><F><T><Q><E><E><W><A><L><L><D><L><A><Q><R><N><L><Y><R><D><V><M><L><E><N><F><Q><N><L><A><S><L><G><Y><P><L><H><T><P><H><L><I><S><Q><W><E><Q><E><E><D><L><Q><T><V><K><R><E><L><I><Q><G><I><F><M><G><E><H><R><E><G><F><E><T><Q><L><K><T><N><E><S><V><A><S><Q><D><I><C><G><E><K><I><S><N><E><Q><K><I><V><R><F><K><R><N><D><S><W><F><S><S><L><H><E><N><Q><E><S><C><G><I><D><Y><Q><N><K><S><H><E><R><H><L><R><N><H><M><V><E><N><I><Y><E><C><Y><E><E><N><Q><D><G><Q><T><F><S><Q><V><P><N><L><D><S><L><K><R><N><T><E><V><K><S><C><E><C><H><E><C><G><K><A><F><V><D><H><S><S><L><K><S><H><I><R><S><H><T><G><S><K><P><Y><Q><C><K><E><C><G><K><A><F><H><F><L><A><C><F><K><K><H><M><K><T><P><T><E><E><K><P><Y><E><C><K><E><C><T><K><A><F><S><C><S><S><F><F><R><A><H><M><K><I><H><I><G><K><T><N><Y><E><C><K><E><C><G><K><G><F><S><C><S><S><S><L><T><E><H><K><R><I><H><S><G><D><K><P><Y><E><C><K><E><C><G><K><A><F><S><C><S><S><S><L><S><K><H><K><R><I><H><S><G><D><K><P><Y><E><C><K><E><C><G><K><A><F><S><S><S><S><H><L><I><I><H><I><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><E><S><S><K><L><T><V><H><G><R><T><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><Y><N><C><P><S><S><L><S><I><H><M><R><K><H><T><G><E><K><P><Y><E><C><L><E><C><G><K><A><F><Y><L><P><T><S><L><N><T><H><V><K><N><Q><S><R><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><C><P><S><S><F><R><A><H><V><R><D><H><T><G><K><I><Q><Y><E><C><K><E><C><G><K><T><F><S><R><S><S><S><L><T><E><H><L><R><T><H><S><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><I><S><S><S><H><L><T><V><H><I><R><T><H><T><G><E><K><P><Y><E><C><K><K><C><G><K><A><F><I><Y><P><S><A><L><R><I><H><M><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><H><S><S><Y><L><T><V><H><A><R><M><H><T><G><E><K><P><F><E><C><L><E><C><G><K><A><F><S><C><P><S><S><F><R><R><H><V><R><S><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><V><C><P><A><Y><F><R><R><H><V><K><T><H><T><R><E><N><I> | May be involved in transcriptional regulation.<BOP> | Q32M78 |
Q14541 | HNF4G_HUMAN | Nuclear receptor subfamily 2 group A member 2 | Homo | <M><N><T><T><D><N><G><V><N><C><L><C><A><I><C><G><D><R><A><T><G><K><H><Y><G><A><S><S><C><D><G><C><K><G><F><F><R><R><S><I><R><K><S><H><V><Y><S><C><R><F><S><R><Q><C><V><V><D><K><D><K><R><N><Q><C><R><Y><C><R><L><R><K><C><F><R><A><G><M><K><K><E><A><V><Q><N><E><R><D><R><I><S><T><R><R><S><T><F><D><G><S><N><I><P><S><I><N><T><L><A><Q><A><E><V><R><S><R><Q><I><S><V><S><S><P><G><S><S><T><D><I><N><V><K><K><I><A><S><I><G><D><V><C><E><S><M><K><Q><Q><L><L><V><L><V><E><W><A><K><Y><I><P><A><F><C><E><L><P><L><D><D><Q><V><A><L><L><R><A><H><A><G><E><H><L><L><L><G><A><T><K><R><S><M><M><Y><K><D><I><L><L><L><G><N><N><Y><V><I><H><R><N><S><C><E><V><E><I><S><R><V><A><N><R><V><L><D><E><L><V><R><P><F><Q><E><I><Q><I><D><D><N><E><Y><A><C><L><K><A><I><V><F><F><D><P><D><A><K><G><L><S><D><P><V><K><I><K><N><M><R><F><Q><V><Q><I><G><L><E><D><Y><I><N><D><R><Q><Y><D><S><R><G><R><F><G><E><L><L><L><L><L><P><T><L><Q><S><I><T><W><Q><M><I><E><Q><I><Q><F><V><K><L><F><G><M><V><K><I><D><N><L><L><Q><E><M><L><L><G><G><A><S><N><D><G><S><H><L><H><H><P><M><H><P><H><L><S><Q><D><P><L><T><G><Q><T><I><L><L><G><P><M><S><T><L><V><H><A><D><Q><I><S><T><P><E><T><P><L><P><S><P><P><Q><G><S><G><Q><E><Q><Y><K><I><A><A><N><Q><A><S><V><I><S><H><Q><H><L><S><K><Q><K><Q><L> | Transcription factor. Has a lower transcription activation potential than HNF4-alpha.<BOP> | Q14541 |
Q8TC44 | POC1B_HUMAN | WD repeat-containing protein 51B | Homo | <M><A><S><A><T><E><D><P><V><L><E><R><Y><F><K><G><H><K><A><A><I><T><S><L><D><L><S><P><N><G><K><Q><L><A><T><A><S><W><D><T><F><L><M><L><W><N><F><K><P><H><A><R><A><Y><R><Y><V><G><H><K><D><V><V><T><S><V><Q><F><S><P><H><G><N><L><L><A><S><A><S><R><D><R><T><V><R><L><W><I><P><D><K><R><G><K><F><S><E><F><K><A><H><T><A><P><V><R><S><V><D><F><S><A><D><G><Q><F><L><A><T><A><S><E><D><K><S><I><K><V><W><S><M><Y><R><Q><R><F><L><Y><S><L><Y><R><H><T><H><W><V><R><C><A><K><F><S><P><D><G><R><L><I><V><S><C><S><E><D><K><T><I><K><I><W><D><T><T><N><K><Q><C><V><N><N><F><S><D><S><V><G><F><A><N><F><V><D><F><N><P><S><G><T><C><I><A><S><A><G><S><D><Q><T><V><K><V><W><D><V><R><V><N><K><L><L><Q><H><Y><Q><V><H><S><G><G><V><N><C><I><S><F><H><P><S><G><N><Y><L><I><T><A><S><S><D><G><T><L><K><I><L><D><L><L><E><G><R><L><I><Y><T><L><Q><G><H><T><G><P><V><F><T><V><S><F><S><K><G><G><E><L><F><A><S><G><G><A><D><T><Q><V><L><L><W><R><T><N><F><D><E><L><H><C><K><G><L><T><K><R><N><L><K><R><L><H><F><D><S><P><P><H><L><L><D><I><Y><P><R><T><P><H><P><H><E><E><K><V><E><T><V><E><I><N><P><K><L><E><V><I><D><L><Q><I><S><T><P><P><V><M><D><I><L><S><F><D><S><T><T><T><T><E><T><S><G><R><T><L><P><D><K><G><E><E><A><C><G><Y><F><L><N><P><S><L><M><S><P><E><C><L><P><T><T><T><K><K><K><T><E><D><M><S><D><L><P><C><E><S><Q><R><S><I><P><L><A><V><T><D><A><L><E><H><I><M><E><Q><L><N><V><L><T><Q><T><V><S><I><L><E><Q><R><L><T><L><T><E><D><K><L><K><D><C><L><E><N><Q><Q><K><L><F><S><A><V><Q><Q><K><S> | Plays an important role in centriole assembly and/or stability and ciliogenesis . Involved in early steps of centriole duplication, as well as in the later steps of centriole length control . Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation . Required for primary cilia formation, ciliary length and also cell proliferation . Required for retinal integrity .<BOP> | Q8TC44 |
Q7L5Y1 | ENOF1_HUMAN | L-fuconate dehydratase | Homo | <M><V><R><G><R><I><S><R><L><S><V><R><D><V><R><F><P><T><S><L><G><G><H><G><A><D><A><M><H><T><D><P><D><Y><S><A><A><Y><V><V><I><E><T><D><A><E><D><G><I><K><G><C><G><I><T><F><T><L><G><K><G><T><E><V><V><V><C><A><V><N><A><L><A><H><H><V><L><N><K><D><L><K><D><I><V><G><D><F><R><G><F><Y><R><Q><L><T><S><D><G><Q><L><R><W><I><G><P><E><K><G><V><V><H><L><A><T><A><A><V><L><N><A><V><W><D><L><W><A><K><Q><E><G><K><P><V><W><K><L><L><V><D><M><D><P><R><M><L><V><S><C><I><D><F><R><Y><I><T><D><V><L><T><E><E><D><A><L><E><I><L><Q><K><G><Q><I><G><K><K><E><R><E><K><Q><M><L><A><Q><G><Y><P><A><Y><T><T><S><C><A><W><L><G><Y><S><D><D><T><L><K><Q><L><C><A><Q><A><L><K><D><G><W><T><R><F><K><V><K><V><G><A><D><L><Q><D><D><M><R><R><C><Q><I><I><R><D><M><I><G><P><E><K><T><L><M><M><D><A><N><Q><R><W><D><V><P><E><A><V><E><W><M><S><K><L><A><K><F><K><P><L><W><I><E><E><P><T><S><P><D><D><I><L><G><H><A><T><I><S><K><A><L><V><P><L><G><I><G><I><A><T><G><E><Q><C><H><N><R><V><I><F><K><Q><L><L><Q><A><K><A><L><Q><F><L><Q><I><D><S><C><R><L><G><S><V><N><E><N><L><S><V><L><L><M><A><K><K><F><E><I><P><V><C><P><H><A><G><G><V><G><L><C><E><L><V><Q><H><L><I><I><F><D><Y><I><S><V><S><A><S><L><E><N><R><V><C><E><Y><V><D><H><L><H><E><H><F><K><Y><P><V><M><I><Q><R><A><S><Y><M><P><P><K><D><P><G><Y><S><T><E><M><K><E><E><S><V><K><K><H><Q><Y><P><D><G><E><V><W><K><K><L><L><P><A><Q><E><N> | Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion .<BOP> | Q7L5Y1 |
Q99519 | NEUR1_HUMAN | N-acetyl-alpha-neuraminidase 1 | Homo | <M><T><G><E><R><P><S><T><A><L><P><D><R><R><W><G><P><R><I><L><G><F><W><G><G><C><R><V><W><V><F><A><A><I><F><L><L><L><S><L><A><A><S><W><S><K><A><E><N><D><F><G><L><V><Q><P><L><V><T><M><E><Q><L><L><W><V><S><G><R><Q><I><G><S><V><D><T><F><R><I><P><L><I><T><A><T><P><R><G><T><L><L><A><F><A><E><A><R><K><M><S><S><S><D><E><G><A><K><F><I><A><L><R><R><S><M><D><Q><G><S><T><W><S><P><T><A><F><I><V><N><D><G><D><V><P><D><G><L><N><L><G><A><V><V><S><D><V><E><T><G><V><V><F><L><F><Y><S><L><C><A><H><K><A><G><C><Q><V><A><S><T><M><L><V><W><S><K><D><D><G><V><S><W><S><T><P><R><N><L><S><L><D><I><G><T><E><V><F><A><P><G><P><G><S><G><I><Q><K><Q><R><E><P><R><K><G><R><L><I><V><C><G><H><G><T><L><E><R><D><G><V><F><C><L><L><S><D><D><H><G><A><S><W><R><Y><G><S><G><V><S><G><I><P><Y><G><Q><P><K><Q><E><N><D><F><N><P><D><E><C><Q><P><Y><E><L><P><D><G><S><V><V><I><N><A><R><N><Q><N><N><Y><H><C><H><C><R><I><V><L><R><S><Y><D><A><C><D><T><L><R><P><R><D><V><T><F><D><P><E><L><V><D><P><V><V><A><A><G><A><V><V><T><S><S><G><I><V><F><F><S><N><P><A><H><P><E><F><R><V><N><L><T><L><R><W><S><F><S><N><G><T><S><W><R><K><E><T><V><Q><L><W><P><G><P><S><G><Y><S><S><L><A><T><L><E><G><S><M><D><G><E><E><Q><A><P><Q><L><Y><V><L><Y><E><K><G><R><N><H><Y><T><E><S><I><S><V><A><K><I><S><V><Y><G><T><L> | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.<BOP> | Q99519 |
Q99685 | MGLL_HUMAN | Monoacylglycerol lipase | Homo | <M><P><E><E><S><S><P><R><R><T><P><Q><S><I><P><Y><Q><D><L><P><H><L><V><N><A><D><G><Q><Y><L><F><C><R><Y><W><K><P><T><G><T><P><K><A><L><I><F><V><S><H><G><A><G><E><H><S><G><R><Y><E><E><L><A><R><M><L><M><G><L><D><L><L><V><F><A><H><D><H><V><G><H><G><Q><S><E><G><E><R><M><V><V><S><D><F><H><V><F><V><R><D><V><L><Q><H><V><D><S><M><Q><K><D><Y><P><G><L><P><V><F><L><L><G><H><S><M><G><G><A><I><A><I><L><T><A><A><E><R><P><G><H><F><A><G><M><V><L><I><S><P><L><V><L><A><N><P><E><S><A><T><T><F><K><V><L><A><A><K><V><L><N><L><V><L><P><N><L><S><L><G><P><I><D><S><S><V><L><S><R><N><K><T><E><V><D><I><Y><N><S><D><P><L><I><C><R><A><G><L><K><V><C><F><G><I><Q><L><L><N><A><V><S><R><V><E><R><A><L><P><K><L><T><V><P><F><L><L><L><Q><G><S><A><D><R><L><C><D><S><K><G><A><Y><L><L><M><E><L><A><K><S><Q><D><K><T><L><K><I><Y><E><G><A><Y><H><V><L><H><K><E><L><P><E><V><T><N><S><V><F><H><E><I><N><M><W><V><S><Q><R><T><A><T><A><G><T><A><S><P><P> | Converts monoacylglycerides to free fatty acids and glycerol . Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain . Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth .<BOP> | Q99685 |
Q9UBW5 | BIN2_HUMAN | Breast cancer-associated protein 1 | Homo | <M><A><E><G><K><A><G><G><A><A><G><L><F><A><K><Q><V><Q><K><K><F><S><R><A><Q><E><K><V><L><Q><K><L><G><K><A><V><E><T><K><D><E><R><F><E><Q><S><A><S><N><F><Y><Q><Q><Q><A><E><G><H><K><L><Y><K><D><L><K><N><F><L><S><A><V><K><V><M><H><E><S><S><K><R><V><S><E><T><L><Q><E><I><Y><S><S><E><W><D><G><H><E><E><L><K><A><I><V><W><N><N><D><L><L><W><E><D><Y><E><E><K><L><A><D><Q><A><V><R><T><M><E><I><Y><V><A><Q><F><S><E><I><K><E><R><I><A><K><R><G><R><K><L><V><D><Y><D><S><A><R><H><H><L><E><A><V><Q><N><A><K><K><K><D><E><A><K><T><A><K><A><E><E><E><F><N><K><A><Q><T><V><F><E><D><L><N><Q><E><L><L><E><E><L><P><I><L><Y><N><S><R><I><G><C><Y><V><T><I><F><Q><N><I><S><N><L><R><D><V><F><Y><R><E><M><S><K><L><N><H><N><L><Y><E><V><M><S><K><L><E><K><Q><H><S><N><K><V><F><V><V><K><G><L><S><S><S><S><R><R><S><L><V><I><S><P><P><V><R><T><A><T><V><S><S><P><L><T><S><P><T><S><P><S><T><L><S><L><K><S><E><S><E><S><V><S><A><T><E><D><L><A><P><D><A><A><Q><G><E><D><N><S><E><I><K><E><L><L><E><E><E><E><I><E><K><E><G><S><E><A><S><S><S><E><E><D><E><P><L><P><A><C><N><G><P><A><Q><A><Q><P><S><P><T><T><E><R><A><K><S><Q><E><E><V><L><P><S><S><T><T><P><S><P><G><G><A><L><S><P><S><G><Q><P><S><S><S><A><T><E><V><V><L><R><T><R><T><A><S><E><G><S><E><Q><P><K><K><R><A><S><I><Q><R><T><S><A><P><P><S><R><P><P><P><P><R><A><T><A><S><P><R><P><S><S><G><N><I><P><S><S><P><T><A><S><G><G><G><S><P><T><S><P><R><A><S><L><G><T><G><T><A><S><P><R><T><S><L><E><V><S><P><N><P><E><P><P><E><K><P><V><R><T><P><E><A><K><E><N><E><N><I><H><N><Q><N><P><E><E><L><C><T><S><P><T><L><M><T><S><Q><V><A><S><E><P><G><E><A><K><K><M><E><D><K><E><K><D><N><K><L><I><S><A><N><S><S><E><G><Q><D><Q><L><Q><V><S><M><V><P><E><N><N><N><L><T><A><P><E><P><Q><E><E><V><S><T><S><E><N><P><Q><L> | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.<BOP> | Q9UBW5 |
P54725 | RD23A_HUMAN | UV excision repair protein RAD23 homolog A | Homo | <M><A><V><T><I><T><L><K><T><L><Q><Q><Q><T><F><K><I><R><M><E><P><D><E><T><V><K><V><L><K><E><K><I><E><A><E><K><G><R><D><A><F><P><V><A><G><Q><K><L><I><Y><A><G><K><I><L><S><D><D><V><P><I><R><D><Y><R><I><D><E><K><N><F><V><V><V><M><V><T><K><T><K><A><G><Q><G><T><S><A><P><P><E><A><S><P><T><A><A><P><E><S><S><T><S><F><P><P><A><P><T><S><G><M><S><H><P><P><P><A><A><R><E><D><K><S><P><S><E><E><S><A><P><T><T><S><P><E><S><V><S><G><S><V><P><S><S><G><S><S><G><R><E><E><D><A><A><S><T><L><V><T><G><S><E><Y><E><T><M><L><T><E><I><M><S><M><G><Y><E><R><E><R><V><V><A><A><L><R><A><S><Y><N><N><P><H><R><A><V><E><Y><L><L><T><G><I><P><G><S><P><E><P><E><H><G><S><V><Q><E><S><Q><V><S><E><Q><P><A><T><E><A><A><G><E><N><P><L><E><F><L><R><D><Q><P><Q><F><Q><N><M><R><Q><V><I><Q><Q><N><P><A><L><L><P><A><L><L><Q><Q><L><G><Q><E><N><P><Q><L><L><Q><Q><I><S><R><H><Q><E><Q><F><I><Q><M><L><N><E><P><P><G><E><L><A><D><I><S><D><V><E><G><E><V><G><A><I><G><E><E><A><P><Q><M><N><Y><I><Q><V><T><P><Q><E><K><E><A><I><E><R><L><K><A><L><G><F><P><E><S><L><V><I><Q><A><Y><F><A><C><E><K><N><E><N><L><A><A><N><F><L><L><S><Q><N><F><D><D><E> | (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.<BOP> | P54725 |
A0A0K0K1A5 | TVB65_HUMAN | T cell receptor beta variable 6-5 | Homo | <M><S><I><G><L><L><C><C><A><A><L><S><L><L><W><A><G><P><V><N><A><G><V><T><Q><T><P><K><F><Q><V><L><K><T><G><Q><S><M><T><L><Q><C><A><Q><D><M><N><H><E><Y><M><S><W><Y><R><Q><D><P><G><M><G><L><R><L><I><H><Y><S><V><G><A><G><I><T><D><Q><G><E><V><P><N><G><Y><N><V><S><R><S><T><T><E><D><F><P><L><R><L><L><S><A><A><P><S><Q><T><S><V><Y><F><C><A><S><S><Y> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0K0K1A5 |
Q1RMZ1 | SAMTR_HUMAN | Probable methyltransferase BMT2 homolog | Homo | <M><E><P><G><A><G><G><R><N><T><A><R><A><Q><R><A><G><S><P><N><T><P><P><P><R><E><Q><E><R><K><L><E><Q><E><K><L><S><G><V><V><K><S><V><H><R><R><L><R><K><K><Y><R><E><V><G><D><F><D><K><I><W><R><E><H><C><E><D><E><E><T><L><C><E><Y><A><V><A><M><K><N><L><A><D><N><H><W><A><K><T><C><E><G><E><G><R><I><E><W><C><C><S><V><C><R><E><Y><F><Q><N><G><G><K><R><K><A><L><E><K><D><E><K><R><A><V><L><A><T><K><T><T><P><A><L><N><M><H><E><S><S><Q><L><E><G><H><L><T><N><L><S><F><T><N><P><E><F><I><T><E><L><L><Q><A><S><G><K><I><R><L><L><D><V><G><S><C><F><N><P><F><L><K><F><E><E><F><L><T><V><G><I><D><I><V><P><A><V><E><S><V><Y><K><C><D><F><L><N><L><Q><L><Q><Q><P><L><Q><L><A><Q><D><A><I><D><A><F><L><K><Q><L><K><N><P><I><D><S><L><P><G><E><L><F><H><V><V><V><F><S><L><L><L><S><Y><F><P><S><P><Y><Q><R><W><I><C><C><K><K><A><H><E><L><L><V><L><N><G><L><L><L><I><I><T><P><D><S><S><H><Q><N><R><H><A><M><M><M><K><S><W><K><I><A><I><E><S><L><G><F><K><R><F><K><Y><S><K><F><S><H><M><H><L><M><A><F><R><K><I><S><L><K><T><T><S><D><L><V><S><R><N><Y><P><G><M><L><Y><I><P><Q><D><F><N><S><I><E><D><E><E><Y><S><N><P><S><C><Y><V><R><S><D><I><E><D><E><Q><L><A><Y><G><F><T><E><L><P><D><A><P><Y><D><S><D><S><G><E><S><Q><A><S><S><I><P><F><Y><E><L><E><D><P><I><L><L><L><S> | S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes . Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling . Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling . Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).<BOP> | Q1RMZ1 |
Q9Y3Q0 | NALD2_HUMAN | N-acetylated-alpha-linked acidic dipeptidase II | Homo | <M><A><E><S><R><G><R><L><Y><L><W><M><C><L><A><A><A><L><A><S><F><L><M><G><F><M><V><G><W><F><I><K><P><L><K><E><T><T><T><S><V><R><Y><H><Q><S><I><R><W><K><L><V><S><E><M><K><A><E><N><I><K><S><F><L><R><S><F><T><K><L><P><H><L><A><G><T><E><Q><N><F><L><L><A><K><K><I><Q><T><Q><W><K><K><F><G><L><D><S><A><K><L><V><H><Y><D><V><L><L><S><Y><P><N><E><T><N><A><N><Y><I><S><I><V><D><E><H><E><T><E><I><F><K><T><S><Y><L><E><P><P><P><D><G><Y><E><N><V><T><N><I><V><P><P><Y><N><A><F><S><A><Q><G><M><P><E><G><D><L><V><Y><V><N><Y><A><R><T><E><D><F><F><K><L><E><R><E><M><G><I><N><C><T><G><K><I><V><I><A><R><Y><G><K><I><F><R><G><N><K><V><K><N><A><M><L><A><G><A><I><G><I><I><L><Y><S><D><P><A><D><Y><F><A><P><E><V><Q><P><Y><P><K><G><W><N><L><P><G><T><A><A><Q><R><G><N><V><L><N><L><N><G><A><G><D><P><L><T><P><G><Y><P><A><K><E><Y><T><F><R><L><D><V><E><E><G><V><G><I><P><R><I><P><V><H><P><I><G><Y><N><D><A><E><I><L><L><R><Y><L><G><G><I><A><P><P><D><K><S><W><K><G><A><L><N><V><S><Y><S><I><G><P><G><F><T><G><S><D><S><F><R><K><V><R><M><H><V><Y><N><I><N><K><I><T><R><I><Y><N><V><V><G><T><I><R><G><S><V><E><P><D><R><Y><V><I><L><G><G><H><R><D><S><W><V><F><G><A><I><D><P><T><S><G><V><A><V><L><Q><E><I><A><R><S><F><G><K><L><M><S><K><G><W><R><P><R><R><T><I><I><F><A><S><W><D><A><E><E><F><G><L><L><G><S><T><E><W><A><E><E><N><V><K><I><L><Q><E><R><S><I><A><Y><I><N><S><D><S><S><I><E><G><N><Y><T><L><R><V><D><C><T><P><L><L><Y><Q><L><V><Y><K><L><T><K><E><I><P><S><P><D><D><G><F><E><S><K><S><L><Y><E><S><W><L><E><K><D><P><S><P><E><N><K><N><L><P><R><I><N><K><L><G><S><G><S><D><F><E><A><Y><F><Q><R><L><G><I><A><S><G><R><A><R><Y><T><K><N><K><K><T><D><K><Y><S><S><Y><P><V><Y><H><T><I><Y><E><T><F><E><L><V><E><K><F><Y><D><P><T><F><K><K><Q><L><S><V><A><Q><L><R><G><A><L><V><Y><E><L><V><D><S><K><I><I><P><F><N><I><Q><D><Y><A><E><A><L><K><N><Y><A><A><S><I><Y><N><L><S><K><K><H><D><Q><Q><L><T><D><H><G><V><S><F><D><S><L><F><S><A><V><K><N><F><S><E><A><A><S><D><F><H><K><R><L><I><Q><V><D><L><N><N><P><I><A><V><R><M><M><N><D><Q><L><M><L><L><E><R><A><F><I><D><P><L><G><L><P><G><K><L><F><Y><R><H><I><I><F><A><P><S><S><H><N><K><Y><A><G><E><S><F><P><G><I><Y><D><A><I><F><D><I><E><N><K><A><N><S><R><L><A><W><K><E><V><K><K><H><I><S><I><A><A><F><T><I><Q><A><A><A><G><T><L><K><E><V><L> | Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.<BOP> | Q9Y3Q0 |
Q8TB37 | NUBPL_HUMAN | huInd1 | Homo | <M><G><I><W><Q><R><L><L><L><F><G><G><V><S><L><R><A><G><G><G><A><T><A><P><L><G><G><S><R><A><M><V><C><G><R><Q><L><S><G><A><G><S><E><T><L><K><Q><R><R><T><Q><I><M><S><R><G><L><P><K><Q><K><P><I><E><G><V><K><Q><V><I><V><V><A><S><G><K><G><G><V><G><K><S><T><T><A><V><N><L><A><L><A><L><A><A><N><D><S><S><K><A><I><G><L><L><D><V><D><V><Y><G><P><S><V><P><K><M><M><N><L><K><G><N><P><E><L><S><Q><S><N><L><M><R><P><L><L><N><Y><G><I><A><C><M><S><M><G><F><L><V><E><E><S><E><P><V><V><W><R><G><L><M><V><M><S><A><I><E><K><L><L><R><Q><V><D><W><G><Q><L><D><Y><L><V><V><D><M><P><P><G><T><G><D><V><Q><L><S><V><S><Q><N><I><P><I><T><G><A><V><I><V><S><T><P><Q><D><I><A><L><M><D><A><H><K><G><A><E><M><F><R><R><V><H><V><P><V><L><G><L><V><Q><N><M><S><V><F><Q><C><P><K><C><K><H><K><T><H><I><F><G><A><D><G><A><R><K><L><A><Q><T><L><G><L><E><V><L><G><D><I><P><L><H><L><N><I><R><E><A><S><D><T><G><Q><P><I><V><F><S><Q><P><E><S><D><E><A><K><A><Y><L><R><I><A><V><E><V><V><R><R><L><P><S><P><S><E> | Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits.<BOP> | Q8TB37 |
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