accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q8WVN6
SCTM1_HUMAN
Protein K-12
Homo
<M><Q><T><C><P><L><A><F><P><G><H><V><S><Q><A><L><G><T><L><L><F><L><A><A><S><L><S><A><Q><N><E><G><W><D><S><P><I><C><T><E><G><V><V><S><V><S><W><G><E><N><T><V><M><S><C><N><I><S><N><A><F><S><H><V><N><I><K><L><R><A><H><G><Q><E><S><A><I><F><N><E><V><A><P><G><Y><F><S><R><D><G><W><Q><L><Q><V><Q><G><G><V><A><Q><L><V><I><K><G><A><R><D><S><H><A><G><L><Y><M><W><H><L><V><G><H><Q><R><N><N><R><Q><V><T><L><E><V><S><G><A><E><P><Q><S><A><P><D><T><G><F><W><P><V><P><A><V><V><T><A><V><F><I><L><L><V><A><L><V><M><F><A><W><Y><R><C><R><C><S><Q><Q><R><R><E><K><K><F><F><L><L><E><P><Q><M><K><V><A><A><L><R><A><G><A><Q><Q><G><L><S><R><A><S><A><E><L><W><T><P><D><S><E><P><T><P><R><P><L><A><L><V><F><K><P><S><P><L><G><A><L><E><L><L><S><P><Q><P><L><F><P><Y><A><A><D><P>
May be involved in thymocyte signaling.<BOP>
Q8WVN6
A9UHW6
MI4GD_HUMAN
SLBP-interacting protein 1
Homo
<M><G><E><P><S><R><E><E><Y><K><I><Q><S><F><D><A><E><T><Q><Q><L><L><K><T><A><L><K><D><P><G><A><V><D><L><E><K><V><A><N><V><I><V><D><H><S><L><Q><D><C><V><F><S><K><E><A><G><R><M><C><Y><A><I><I><Q><A><E><S><K><Q><A><G><Q><S><V><F><R><R><G><L><L><N><R><L><Q><Q><E><Y><Q><A><R><E><Q><L><R><A><R><S><L><Q><G><W><V><C><Y><V><T><F><I><C><N><I><F><D><Y><L><R><V><N><N><M><P><M><M><A><L><V><N><P><V><Y><D><C><L><F><R><L><A><Q><P><D><S><L><S><K><E><E><E><V><D><C><L><V><L><Q><L><H><R><V><G><E><Q><L><E><K><M><N><G><Q><R><M><D><E><L><F><V><L><I><R><D><G><F><L><L><P><T><G><L><S><S><L><A><Q><L><L><L><L><E><I><I><E><F><R><A><A><G><W><K><T><T><P><A><A><H><K><Y><Y><Y><S><E><V><S><D>
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.<BOP>
A9UHW6
P30041
PRDX6_HUMAN
Red blood cells page spot 12
Homo
<M><P><G><G><L><L><L><G><D><V><A><P><N><F><E><A><N><T><T><V><G><R><I><R><F><H><D><F><L><G><D><S><W><G><I><L><F><S><H><P><R><D><F><T><P><V><C><T><T><E><L><G><R><A><A><K><L><A><P><E><F><A><K><R><N><V><K><L><I><A><L><S><I><D><S><V><E><D><H><L><A><W><S><K><D><I><N><A><Y><N><C><E><E><P><T><E><K><L><P><F><P><I><I><D><D><R><N><R><E><L><A><I><L><L><G><M><L><D><P><A><E><K><D><E><K><G><M><P><V><T><A><R><V><V><F><V><F><G><P><D><K><K><L><K><L><S><I><L><Y><P><A><T><T><G><R><N><F><D><E><I><L><R><V><V><I><S><L><Q><L><T><A><E><K><R><V><A><T><P><V><D><W><K><D><G><D><S><V><M><V><L><P><T><I><P><E><E><E><A><K><K><L><F><P><K><G><V><F><T><K><E><L><P><S><G><K><K><Y><L><R><Y><T><P><Q><P>
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively . Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides . Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) . These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH . Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis . Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) . Shows a clear preference for LPC as
P30041
O00142
KITM_HUMAN
Mt-TK
Homo
<M><L><L><W><P><L><R><G><W><A><A><R><A><L><R><C><F><G><P><G><S><R><G><S><P><A><S><G><P><G><P><R><R><V><Q><R><R><A><W><P><P><D><K><E><Q><E><K><E><K><K><S><V><I><C><V><E><G><N><I><A><S><G><K><T><T><C><L><E><F><F><S><N><A><T><D><V><E><V><L><T><E><P><V><S><K><W><R><N><V><R><G><H><N><P><L><G><L><M><Y><H><D><A><S><R><W><G><L><T><L><Q><T><Y><V><Q><L><T><M><L><D><R><H><T><R><P><Q><V><S><S><V><R><L><M><E><R><S><I><H><S><A><R><Y><I><F><V><E><N><L><Y><R><S><G><K><M><P><E><V><D><Y><V><V><L><S><E><W><F><D><W><I><L><R><N><M><D><V><S><V><D><L><I><V><Y><L><R><T><N><P><E><T><C><Y><Q><R><L><K><K><R><C><R><E><E><E><K><V><I><P><L><E><Y><L><E><A><I><H><H><L><H><E><E><W><L><I><K><G><S><L><F><P><M><A><A><P><V><L><V><I><E><A><D><H><H><M><E><R><M><L><E><L><F><E><Q><N><R><D><R><I><L><T><P><E><N><R><K><H><C><P>
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix . In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK . Widely used as target of antiviral and chemotherapeutic agents .<BOP>
O00142
Q8TF64
GIPC3_HUMAN
PDZ domain-containing protein GIPC3
Homo
<M><E><G><A><A><A><R><E><A><R><G><T><E><T><P><R><A><S><A><P><P><P><A><P><S><E><P><P><A><A><P><R><A><R><P><R><L><V><F><R><T><Q><L><A><H><G><S><P><T><G><K><I><E><G><F><T><N><V><R><E><L><Y><A><K><I><A><E><A><F><G><I><A><P><T><E><I><L><F><C><T><L><N><S><H><K><V><D><M><Q><K><L><L><G><G><Q><I><G><L><E><D><F><I><F><A><H><V><R><G><E><T><K><E><V><E><V><T><K><T><E><D><A><L><G><L><T><I><T><D><N><G><A><G><Y><A><F><I><K><R><I><K><E><G><S><I><I><N><R><I><E><A><V><C><V><G><D><S><I><E><A><I><N><D><H><S><I><V><G><C><R><H><Y><E><V><A><K><M><L><R><E><L><P><K><S><Q><P><F><T><L><R><L><V><Q><P><K><R><A><F><D><M><I><G><Q><R><S><R><S><S><K><C><P><V><E><A><K><V><T><S><G><R><E><T><L><R><L><R><S><G><G><A><A><T><V><E><E><A><P><S><E><F><E><E><E><A><S><R><K><V><D><D><L><L><E><S><Y><M><G><I><R><D><P><E><L><A><S><T><M><V><E><T><S><K><K><T><A><S><A><Q><E><F><A><R><C><L><D><S><V><L><G><E><F><A><F><P><D><E><F><V><V><E><V><W><A><A><I><G><E><A><R><E><A><C><G>
Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion.<BOP>
Q8TF64
Q96SZ4
ZSC10_HUMAN
Zinc finger protein 206
Homo
<M><G><P><R><A><S><L><S><R><L><R><E><L><C><G><H><W><L><R><P><A><L><H><T><K><K><Q><I><L><E><L><L><V><L><E><Q><F><L><S><V><L><P><P><H><L><L><G><R><L><Q><G><Q><P><L><R><D><G><E><E><V><V><L><L><L><E><G><I><H><R><E><P><S><H><A><G><P><L><D><F><S><C><N><A><G><K><S><C><P><R><A><D><V><T><L><E><E><K><G><C><A><S><Q><V><P><S><H><S><P><K><K><E><L><P><A><E><E><P><S><V><L><G><P><S><D><E><P><P><R><P><Q><P><R><A><A><Q><P><A><E><P><G><Q><W><R><L><P><P><S><S><K><Q><P><L><S><P><G><P><Q><K><T><F><Q><A><L><Q><E><S><S><P><Q><G><P><S><P><W><P><E><E><S><S><R><D><Q><E><L><A><A><V><L><E><C><L><T><F><E><D><V><P><E><N><K><A><W><P><A><H><P><L><G><F><G><S><R><T><P><D><K><E><E><F><K><Q><E><E><P><K><G><A><A><W><P><T><P><I><L><A><E><S><Q><A><D><S><P><G><V><P><G><E><P><C><A><Q><S><L><G><R><G><A><A><A><S><G><P><G><E><D><G><S><L><L><G><S><S><E><I><L><E><V><K><V><A><E><G><V><P><E><P><N><P><E><L><Q><F><I><C><A><D><C><G><V><S><F><P><Q><L><S><R><L><K><A><H><Q><L><R><S><H><P><A><G><R><S><F><L><C><L><C><C><G><K><S><F><G><R><S><S><I><L><K><L><H><M><R><T><H><T><D><E><R><P><H><A><C><H><L><C><G><H><R><F><R><Q><S><S><H><L><S><K><H><L><L><T><H><S><S><E><P><A><F><L><C><A><E><C><G><R><G><F><Q><R><R><A><S><L><V><Q><H><L><L><A><H><A><Q><D><Q><K><P><P><C><A><P><E><S><K><A><E><A><P><P><L><T><D><V><L><C><S><H><C><G><Q><S><F><Q><R><R><S><S><L><K><R><H><L><R><I><H><A><R><D><K><D><R><R><S><S><E><G><S><G><S><R><R><R><D><S><D><R><R><P><F><V><C><S><D><C><G><K><A><F><R><R><S><E><H><L><V><A><H><R><R><V><H><T><G><E><R><P><F><S><C><Q><A><C><G><R><S><F><T><Q><S><S><Q><L><V><S><H><Q><R><V><H><T><G><E><K><P><Y><A><C><P><Q><C><G><K><R><F><V><R><R><A><S><L><A><R><H><L><L><T><H><G><G><P><R><P><H><H><C><T><Q><C><G><K><S><F><G><Q><T><Q><D><L><A><R><H><Q><R><S><H><T><G><E><K><P><C><R><C><S><E><C><G><E><G><F><S><Q><S><A><H><L><A><R><H><Q><R><I><H><T><G><E><K><P><H><A><C><D><T><C><G><H><R><F><R><N><S><S><N><L><A><R><H><R><R><S><H><T><G><E><R><P><Y><S><C><Q><T><C><G><R><S><F><R><R><N><A><H><L><R><R><H><L><A><T><H><A><E><P><G><Q><E><Q><A><E><P><P><Q><E><C><V><E><C><G><K><S><F><S><R><S><C><N><L><L><R><H><L><L><V><H><T><G><A><R><P><Y><S><C><T><Q><C><G><R><S><F><S><R><N><S><H><L><L><R><H><L><R><T><H><A><R><E><T><L><Y>
Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.<BOP>
Q96SZ4
P78310
CXAR_HUMAN
HCVADR
Homo
<M><A><L><L><L><C><F><V><L><L><C><G><V><V><D><F><A><R><S><L><S><I><T><T><P><E><E><M><I><E><K><A><K><G><E><T><A><Y><L><P><C><K><F><T><L><S><P><E><D><Q><G><P><L><D><I><E><W><L><I><S><P><A><D><N><Q><K><V><D><Q><V><I><I><L><Y><S><G><D><K><I><Y><D><D><Y><Y><P><D><L><K><G><R><V><H><F><T><S><N><D><L><K><S><G><D><A><S><I><N><V><T><N><L><Q><L><S><D><I><G><T><Y><Q><C><K><V><K><K><A><P><G><V><A><N><K><K><I><H><L><V><V><L><V><K><P><S><G><A><R><C><Y><V><D><G><S><E><E><I><G><S><D><F><K><I><K><C><E><P><K><E><G><S><L><P><L><Q><Y><E><W><Q><K><L><S><D><S><Q><K><M><P><T><S><W><L><A><E><M><T><S><S><V><I><S><V><K><N><A><S><S><E><Y><S><G><T><Y><S><C><T><V><R><N><R><V><G><S><D><Q><C><L><L><R><L><N><V><V><P><P><S><N><K><A><G><L><I><A><G><A><I><I><G><T><L><L><A><L><A><L><I><G><L><I><I><F><C><C><R><K><K><R><R><E><E><K><Y><E><K><E><V><H><H><D><I><R><E><D><V><P><P><P><K><S><R><T><S><T><A><R><S><Y><I><G><S><N><H><S><S><L><G><S><M><S><P><S><N><M><E><G><Y><S><K><T><Q><Y><N><Q><V><P><S><E><D><F><E><R><T><P><Q><S><P><T><L><P><P><A><K><V><A><A><P><N><L><S><R><M><G><A><I><P><V><M><I><P><A><Q><S><K><D><G><S><I><V>
(Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.<BOP>
P78310
Q8N0Z2
ABRA_HUMAN
Striated muscle activator of Rho-dependent signaling
Homo
<M><A><P><G><E><K><E><S><G><E><G><P><A><K><S><A><L><R><K><I><R><T><A><T><L><V><I><S><L><A><R><G><W><Q><Q><W><A><N><E><N><S><I><R><Q><A><Q><E><P><T><G><W><L><P><G><G><T><Q><D><S><P><Q><A><P><K><P><I><T><P><P><T><S><H><Q><K><A><Q><S><A><P><K><S><P><P><R><L><P><E><G><H><G><D><G><Q><S><S><E><K><A><P><E><V><S><H><I><K><K><K><E><V><S><K><T><V><V><S><K><T><Y><E><R><G><G><D><V><S><H><L><S><H><R><Y><E><R><D><A><G><V><L><E><P><G><Q><P><E><N><D><I><D><R><I><L><H><S><H><G><S><P><T><R><R><R><K><C><A><N><L><V><S><E><L><T><K><G><W><R><V><M><E><Q><E><E><P><T><W><R><S><D><S><V><D><T><E><D><S><G><Y><G><G><E><A><E><E><R><P><E><Q><D><G><V><Q><V><A><V><V><R><I><K><R><P><L><P><S><Q><V><N><R><F><T><E><K><L><N><C><K><A><Q><Q><K><Y><S><P><V><G><N><L><K><G><R><W><Q><Q><W><A><D><E><H><I><Q><S><Q><K><L><N><P><F><S><E><E><F><D><Y><E><L><A><M><S><T><R><L><H><K><G><D><E><G><Y><G><R><P><K><E><G><T><K><T><A><E><R><A><K><R><A><E><E><H><I><Y><R><E><M><M><D><M><C><F><I><I><C><T><M><A><R><H><R><R><D><G><K><I><Q><V><T><F><G><D><L><F><D><R><Y><V><R><I><S><D><K><V><V><G><I><L><M><R><A><R><K><H><G><L><V><D><F><E><G><E><M><L><W><Q><G><R><D><D><H><V><V><I><T><L><L><K>
Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.<BOP>
Q8N0Z2
P02795
MT2_HUMAN
Metallothionein-II
Homo
<M><D><P><N><C><S><C><A><A><G><D><S><C><T><C><A><G><S><C><K><C><K><E><C><K><C><T><S><C><K><K><S><C><C><S><C><C><P><V><G><C><A><K><C><A><Q><G><C><I><C><K><G><A><S><D><K><C><S><C><C><A>
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.<BOP>
P02795
O14836
TR13B_HUMAN
Transmembrane activator and CAML interactor
Homo
<M><S><G><L><G><R><S><R><R><G><G><R><S><R><V><D><Q><E><E><R><F><P><Q><G><L><W><T><G><V><A><M><R><S><C><P><E><E><Q><Y><W><D><P><L><L><G><T><C><M><S><C><K><T><I><C><N><H><Q><S><Q><R><T><C><A><A><F><C><R><S><L><S><C><R><K><E><Q><G><K><F><Y><D><H><L><L><R><D><C><I><S><C><A><S><I><C><G><Q><H><P><K><Q><C><A><Y><F><C><E><N><K><L><R><S><P><V><N><L><P><P><E><L><R><R><Q><R><S><G><E><V><E><N><N><S><D><N><S><G><R><Y><Q><G><L><E><H><R><G><S><E><A><S><P><A><L><P><G><L><K><L><S><A><D><Q><V><A><L><V><Y><S><T><L><G><L><C><L><C><A><V><L><C><C><F><L><V><A><V><A><C><F><L><K><K><R><G><D><P><C><S><C><Q><P><R><S><R><P><R><Q><S><P><A><K><S><S><Q><D><H><A><M><E><A><G><S><P><V><S><T><S><P><E><P><V><E><T><C><S><F><C><F><P><E><C><R><A><P><T><Q><E><S><A><V><T><P><G><T><P><D><P><T><C><A><G><R><W><G><C><H><T><R><T><T><V><L><Q><P><C><P><H><I><P><D><S><G><L><G><I><V><C><V><P><A><Q><E><G><G><P><G><A>
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.<BOP>
O14836
Q30KQ4
DB116_HUMAN
Defensin, beta 116
Homo
<M><S><V><M><K><P><C><L><M><T><I><A><I><L><M><I><L><A><Q><K><T><P><G><G><L><F><R><S><H><N><G><K><S><R><E><P><W><N><P><C><E><L><Y><Q><G><M><C><R><N><A><C><R><E><Y><E><I><Q><Y><L><T><C><P><N><D><Q><K><C><C><L><K><L><S><V><K><I><T><S><S><K><N><V><K><E><D><Y><D><S><N><S><N><L><S><V><T><N><S><S><S><Y><S><H><I>
Has antibacterial activity.<BOP>
Q30KQ4
Q9NX38
ABITM_HUMAN
Protein Simiate
Homo
<M><A><T><E><P><E><A><A><E><P><V><V><P><S><L><V><D><R><Y><F><T><R><W><Y><K><P><D><V><K><G><K><F><C><E><D><H><C><I><L><Q><H><S><N><R><I><C><V><I><T><L><A><E><S><H><P><V><L><Q><S><G><K><T><I><K><S><I><S><Y><Q><I><S><T><N><C><S><R><L><Q><N><K><V><S><G><K><F><K><R><G><A><Q><F><L><T><E><L><A><P><L><C><K><I><Y><C><S><D><G><E><E><Y><T><V><S><S><C><V><R><G><R><L><M><E><V><N><E><N><I><L><H><K><P><S><I><L><Q><E><K><P><S><T><E><G><Y><I><A><V><V><L><P><K><F><E><E><S><K><S><I><T><E><G><L><L><T><Q><K><Q><Y><E><E><V><M><V><K><R><I><N><A><T><T><A><T><S>
Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.<BOP>
Q9NX38
Q9H342
O51J1_HUMAN
Olfactory receptor 51J2
Homo
<M><K><I><S><N><N><S><L><G><F><L><P><T><T><F><I><L><V><G><I><P><G><L><E><S><E><H><L><W><I><S><V><P><F><S><L><I><Y><I><I><I><F><L><G><N><G><I><I><L><H><V><I><R><T><D><I><A><L><H><Q><P><M><Y><L><F><L><A><M><L><A><L><A><E><V><R><V><S><A><S><T><L><P><T><V><L><G><I><F><L><F><G><N><T><E><I><S><L><E><A><C><L><F><P><D><V><L><H><P><F><F><I><H><D><G><A><S><C><A><A><G><H><V><F><G><P><L><Y><S><H><L><Q><P><T><E><L><H><S><Y><P><D><T><A><Q><G><L><W><H><R><S><Y><Y><R><T><E><K><H><Y><A><H><G><S><V><A><H><S><L><M><A><S><A><L><L><W><P><Q><C><P><L><T><F><L><L><S><A><P><Q><S><Y><L><S><C><G><N><I><S><V><N><N><I><Y><G><I><F><I><V><T><S><T><F><G><L><D><S><L><L><I><V><I><S><Y><G><L><I><L><H><T><V><L><G><I><A><T><G><E><G><R><K><K><A><L><N><T><C><G><S><H><V><C><A><V><L><A><Y><Y><V><P><M><I><G><L><S><I><V><H><R><L><G><H><R><V><S><P><L><L><Q><A><M><M><A><N><A><Y><L><F><F><P><P><V><V><N><P><I><V><Y><S><I><K><T><K><E><I><H><G><A><I><V><R><M><L><L><E><K><R><R><R><V>
Odorant receptor.<BOP>
Q9H342
P45379
TNNT2_HUMAN
Cardiac muscle troponin T
Homo
<M><S><D><I><E><E><V><V><E><E><Y><E><E><E><E><Q><E><E><A><A><V><E><E><E><E><D><W><R><E><D><E><D><E><Q><E><E><A><A><E><E><D><A><E><A><E><A><E><T><E><E><T><R><A><E><E><D><E><E><E><E><E><A><K><E><A><E><D><G><P><M><E><E><S><K><P><K><P><R><S><F><M><P><N><L><V><P><P><K><I><P><D><G><E><R><V><D><F><D><D><I><H><R><K><R><M><E><K><D><L><N><E><L><Q><A><L><I><E><A><H><F><E><N><R><K><K><E><E><E><E><L><V><S><L><K><D><R><I><E><R><R><R><A><E><R><A><E><Q><Q><R><I><R><N><E><R><E><K><E><R><Q><N><R><L><A><E><E><R><A><R><R><E><E><E><E><N><R><R><K><A><E><D><E><A><R><K><K><K><A><L><S><N><M><M><H><F><G><G><Y><I><Q><K><Q><A><Q><T><E><R><K><S><G><K><R><Q><T><E><R><E><K><K><K><K><I><L><A><E><R><R><K><V><L><A><I><D><H><L><N><E><D><Q><L><R><E><K><A><K><E><L><W><Q><S><I><Y><N><L><E><A><E><K><F><D><L><Q><E><K><F><K><Q><Q><K><Y><E><I><N><V><L><R><N><R><I><N><D><N><Q><K><V><S><K><T><R><G><K><A><K><V><T><G><R><W><K>
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.<BOP>
P45379
P25103
NK1R_HUMAN
Tachykinin receptor 1
Homo
<M><D><N><V><L><P><V><D><S><D><L><S><P><N><I><S><T><N><T><S><E><P><N><Q><F><V><Q><P><A><W><Q><I><V><L><W><A><A><A><Y><T><V><I><V><V><T><S><V><V><G><N><V><V><V><M><W><I><I><L><A><H><K><R><M><R><T><V><T><N><Y><F><L><V><N><L><A><F><A><E><A><S><M><A><A><F><N><T><V><V><N><F><T><Y><A><V><H><N><E><W><Y><Y><G><L><F><Y><C><K><F><H><N><F><F><P><I><A><A><V><F><A><S><I><Y><S><M><T><A><V><A><F><D><R><Y><M><A><I><I><H><P><L><Q><P><R><L><S><A><T><A><T><K><V><V><I><C><V><I><W><V><L><A><L><L><L><A><F><P><Q><G><Y><Y><S><T><T><E><T><M><P><S><R><V><V><C><M><I><E><W><P><E><H><P><N><K><I><Y><E><K><V><Y><H><I><C><V><T><V><L><I><Y><F><L><P><L><L><V><I><G><Y><A><Y><T><V><V><G><I><T><L><W><A><S><E><I><P><G><D><S><S><D><R><Y><H><E><Q><V><S><A><K><R><K><V><V><K><M><M><I><V><V><V><C><T><F><A><I><C><W><L><P><F><H><I><F><F><L><L><P><Y><I><N><P><D><L><Y><L><K><K><F><I><Q><Q><V><Y><L><A><I><M><W><L><A><M><S><S><T><M><Y><N><P><I><I><Y><C><C><L><N><D><R><F><R><L><G><F><K><H><A><F><R><C><C><P><F><I><S><A><G><D><Y><E><G><L><E><M><K><S><T><R><Y><L><Q><T><Q><G><S><V><Y><K><V><S><R><L><E><T><T><I><S><T><V><V><G><A><H><E><E><E><P><E><D><G><P><K><A><T><P><S><S><L><D><L><T><S><N><C><S><S><R><S><D><S><K><T><M><T><E><S><F><S><F><S><S><N><V><L><S>
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.<BOP>
P25103
Q8TD17
ZN398_HUMAN
Zinc finger DNA-binding protein p52/p71
Homo
<M><A><E><A><A><P><A><P><T><S><E><W><D><S><E><C><L><T><S><L><Q><P><L><P><L><P><T><P><P><A><A><N><E><A><H><L><Q><T><A><A><I><S><L><W><T><V><V><A><A><V><Q><A><I><E><R><K><V><E><I><H><S><R><R><L><L><H><L><E><G><R><T><G><T><A><E><K><K><L><A><S><C><E><K><T><V><T><E><L><G><N><Q><L><E><G><K><W><A><V><L><G><T><L><L><Q><E><Y><G><L><L><Q><R><R><L><E><N><L><E><N><L><L><R><N><R><N><F><W><I><L><R><L><P><P><G><I><K><G><D><I><P><K><V><P><V><A><F><D><D><V><S><I><Y><F><S><T><P><E><W><E><K><L><E><E><W><Q><K><E><L><Y><K><N><I><M><K><G><N><Y><E><S><L><I><S><M><D><Y><A><I><N><Q><P><D><V><L><S><Q><I><Q><P><E><G><E><H><N><T><E><D><Q><A><G><P><E><E><S><E><I><P><T><D><P><S><E><E><P><G><I><S><T><S><D><I><L><S><W><I><K><Q><E><E><E><P><Q><V><G><A><P><P><E><S><K><E><S><D><V><Y><K><S><T><Y><A><D><E><E><L><V><I><K><A><E><G><L><A><R><S><S><L><C><P><E><V><P><V><P><F><S><S><P><P><A><A><A><K><D><A><F><S><D><V><A><F><K><S><Q><Q><S><T><S><M><T><P><F><G><R><P><A><T><D><L><P><E><A><S><E><G><Q><V><T><F><T><Q><L><G><S><Y><P><L><P><P><P><V><G><E><Q><V><F><S><C><H><H><C><G><K><N><L><S><Q><D><M><L><L><T><H><Q><C><S><H><A><T><E><H><P><L><P><C><A><Q><C><P><K><H><F><T><P><Q><A><D><L><S><S><T><S><Q><D><H><A><S><E><T><P><P><T><C><P><H><C><A><R><T><F><T><H><P><S><R><L><T><Y><H><L><R><V><H><N><S><T><E><R><P><F><P><C><P><D><C><P><K><R><F><A><D><Q><A><R><L><T><S><H><R><R><A><H><A><S><E><R><P><F><R><C><A><Q><C><G><R><S><F><S><L><K><I><S><L><L><L><H><Q><R><G><H><A><Q><E><R><P><F><S><C><P><Q><C><G><I><D><F><N><G><H><S><A><L><I><R><H><Q><M><I><H><T><G><E><R><P><Y><P><C><T><D><C><S><K><S><F><M><R><K><E><H><L><L><N><H><R><R><L><H><T><G><E><R><P><F><S><C><P><H><C><G><K><S><F><I><R><K><H><H><L><M><K><H><Q><R><I><H><T><G><E><R><P><Y><P><C><S><Y><C><G><R><S><F><R><Y><K><Q><T><L><K><D><H><L><R><S><G><H><N><G><G><C><G><G><D><S><D><P><S><G><Q><P><P><N><P><P><G><P><L><I><T><G><L><E><T><S><G><L><G><V><N><T><E><G><L><E><T><N><Q><W><Y><G><E><G><S><G><G><G><V><L>
Functions as a transcriptional activator.<BOP>
Q8TD17
P21108
PRPS3_HUMAN
Phosphoribosyl pyrophosphate synthase III
Homo
<M><P><N><I><K><I><F><S><G><S><S><H><Q><D><L><S><Q><K><I><A><D><R><L><G><L><E><L><G><K><V><V><T><K><K><F><S><N><Q><E><T><C><V><E><I><D><E><S><V><R><G><E><D><V><Y><I><V><Q><S><G><C><G><E><I><N><D><S><L><M><E><L><L><I><M><I><N><A><C><K><I><A><S><A><S><R><V><T><A><V><I><P><C><F><P><Y><A><R><Q><D><K><K><D><K><S><R><S><P><I><S><A><K><L><V><A><N><M><L><S><I><A><G><A><D><H><I><I><T><M><D><L><H><A><S><Q><I><Q><G><F><F><D><I><P><V><D><N><L><Y><A><E><P><T><V><L><K><W><I><R><E><N><I><P><E><W><K><N><C><I><I><V><S><P><D><A><G><G><A><K><R><V><T><S><I><A><D><Q><L><N><V><D><F><A><L><I><H><K><E><R><K><K><A><N><E><V><D><C><I><V><L><V><G><D><V><N><D><R><V><A><I><L><V><D><D><M><A><D><T><C><V><T><I><C><L><A><A><D><K><L><L><S><A><G><A><T><R><V><Y><A><I><L><T><H><G><I><F><S><G><P><A><I><S><R><I><N><T><A><C><F><E><A><V><V><V><T><N><T><I><P><Q><D><E><K><M><K><H><C><S><K><I><R><V><I><D><I><S><M><I><L><A><E><A><I><R><R><T><H><N><G><E><S><V><S><Y><L><F><S><H><V><P><L>
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.<BOP>
P21108
Q9HB90
RRAGC_HUMAN
TIB929
Homo
<M><S><L><Q><Y><G><A><E><E><T><P><L><A><G><S><Y><G><A><A><D><S><F><P><K><D><F><G><Y><G><V><E><E><E><E><E><E><A><A><A><A><G><G><G><V><G><A><G><A><G><G><G><C><G><P><G><G><A><D><S><S><K><P><R><I><L><L><M><G><L><R><R><S><G><K><S><S><I><Q><K><V><V><F><H><K><M><S><P><N><E><T><L><F><L><E><S><T><N><K><I><Y><K><D><D><I><S><N><S><S><F><V><N><F><Q><I><W><D><F><P><G><Q><M><D><F><F><D><P><T><F><D><Y><E><M><I><F><R><G><T><G><A><L><I><Y><V><I><D><A><Q><D><D><Y><M><E><A><L><T><R><L><H><I><T><V><S><K><A><Y><K><V><N><P><D><M><N><F><E><V><F><I><H><K><V><D><G><L><S><D><D><H><K><I><E><T><Q><R><D><I><H><Q><R><A><N><D><D><L><A><D><A><G><L><E><K><L><H><L><S><F><Y><L><T><S><I><Y><D><H><S><I><F><E><A><F><S><K><V><V><Q><K><L><I><P><Q><L><P><T><L><E><N><L><L><N><I><F><I><S><N><S><G><I><E><K><A><F><L><F><D><V><V><S><K><I><Y><I><A><T><D><S><S><P><V><D><M><Q><S><Y><E><L><C><C><D><M><I><D><V><V><I><D><V><S><C><I><Y><G><L><K><E><D><G><S><G><S><A><Y><D><K><E><S><M><A><I><I><K><L><N><N><T><T><V><L><Y><L><K><E><V><T><K><F><L><A><L><V><C><I><L><R><E><E><S><F><E><R><K><G><L><I><D><Y><N><F><H><C><F><R><K><A><I><H><E><V><F><E><V><G><V><T><S><H><R><S><C><G><H><Q><T><S><A><S><S><L><K><A><L><T><H><N><G><T><P><R><N><A><I>
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade . Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form . In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB . This is a crucial step in the activation of the TOR signaling cascade by amino acids .<BOP>
Q9HB90
Q8NGF3
O51D1_HUMAN
Olfactory receptor OR11-14
Homo
<M><Q><K><P><Q><L><L><V><P><I><I><A><T><S><N><G><N><L><V><H><A><A><Y><F><L><L><V><G><I><P><G><L><G><P><T><I><H><F><W><L><A><F><P><L><C><F><M><Y><A><L><A><T><L><G><N><L><T><I><V><L><I><I><R><V><E><R><R><L><H><E><P><M><Y><L><F><L><A><M><L><S><T><I><D><L><V><L><S><S><I><T><M><P><K><M><A><S><L><F><L><M><G><I><Q><E><I><E><F><N><I><C><L><A><Q><M><F><L><I><H><A><L><S><A><V><E><S><A><V><L><L><A><M><A><F><D><R><F><V><A><I><C><H><P><L><R><H><A><S><V><L><T><G><C><T><V><A><K><I><G><L><S><A><L><T><R><G><F><V><F><F><F><P><L><P><F><I><L><K><W><L><S><Y><C><Q><T><H><T><V><T><H><S><F><C><L><H><Q><D><I><M><K><L><S><C><T><D><T><R><V><N><V><V><Y><G><L><F><I><I><L><S><V><M><G><V><D><S><L><F><I><G><F><S><Y><I><L><I><L><W><A><V><L><E><L><S><S><R><R><A><A><L><K><A><F><N><T><C><I><S><H><L><C><A><V><L><V><F><Y><V><P><L><I><G><L><S><V><V><H><R><L><G><G><P><T><S><L><L><H><V><V><M><A><N><T><Y><L><L><L><P><P><V><V><N><P><L><V><Y><G><A><K><T><K><E><I><C><S><R><V><L><C><M><F><S><Q><G><G><K>
Odorant receptor.<BOP>
Q8NGF3
O60507
TPST1_HUMAN
Tyrosylprotein sulfotransferase 1
Homo
<M><V><G><K><L><K><Q><N><L><L><L><A><C><L><V><I><S><S><V><T><V><F><Y><L><G><Q><H><A><M><E><C><H><H><R><I><E><E><R><S><Q><P><V><K><L><E><S><T><R><T><T><V><R><T><G><L><D><L><K><A><N><K><T><F><A><Y><H><K><D><M><P><L><I><F><I><G><G><V><P><R><S><G><T><T><L><M><R><A><M><L><D><A><H><P><D><I><R><C><G><E><E><T><R><V><I><P><R><I><L><A><L><K><Q><M><W><S><R><S><S><K><E><K><I><R><L><D><E><A><G><V><T><D><E><V><L><D><S><A><M><Q><A><F><L><L><E><I><I><V><K><H><G><E><P><A><P><Y><L><C><N><K><D><P><F><A><L><K><S><L><T><Y><L><S><R><L><F><P><N><A><K><F><L><L><M><V><R><D><G><R><A><S><V><H><S><M><I><S><R><K><V><T><I><A><G><F><D><L><N><S><Y><R><D><C><L><T><K><W><N><R><A><I><E><T><M><Y><N><Q><C><M><E><V><G><Y><K><K><C><M><L><V><H><Y><E><Q><L><V><L><H><P><E><R><W><M><R><T><L><L><K><F><L><Q><I><P><W><N><H><S><V><L><H><H><E><E><M><I><G><K><A><G><G><V><S><L><S><K><V><E><R><S><T><D><Q><V><I><K><P><V><N><V><G><A><L><S><K><W><V><G><K><I><P><P><D><V><L><Q><D><M><A><V><I><A><P><M><L><A><K><L><G><Y><D><P><Y><A><N><P><P><N><Y><G><K><P><D><P><K><I><I><E><N><T><R><R><V><Y><K><G><E><F><Q><L><P><D><F><L><K><E><K><P><Q><T><E><Q><V><E>
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.<BOP>
O60507
O75506
HSBP1_HUMAN
Nasopharyngeal carcinoma-associated antigen 13
Homo
<M><A><E><T><D><P><K><T><V><Q><D><L><T><S><V><V><Q><T><L><L><Q><Q><M><Q><D><K><F><Q><T><M><S><D><Q><I><I><G><R><I><D><D><M><S><S><R><I><D><D><L><E><K><N><I><A><D><L><M><T><Q><A><G><V><E><E><L><E><S><E><N><K><I><P><A><T><Q><K><S>
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.<BOP>
O75506
Q8NGD3
OR4K5_HUMAN
Olfactory receptor OR14-16
Homo
<M><D><K><S><N><S><S><V><V><S><E><F><V><L><L><G><L><C><S><S><Q><K><L><Q><L><F><Y><F><C><F><F><S><V><L><Y><T><V><I><V><L><G><N><L><L><I><I><L><T><V><T><S><D><T><S><L><H><S><P><M><Y><F><L><L><G><N><L><S><F><V><D><I><C><Q><A><S><F><A><T><P><K><M><I><A><D><F><L><S><A><H><E><T><I><S><F><S><G><C><I><A><Q><I><F><F><I><H><L><F><T><G><G><E><M><V><L><L><V><S><M><A><Y><D><R><Y><V><A><I><C><K><P><L><Y><Y><V><V><I><M><S><R><R><T><C><T><V><L><V><M><I><S><W><A><V><S><L><V><H><T><L><S><Q><L><S><F><T><V><N><L><P><F><C><G><P><N><V><V><D><S><F><F><C><D><L><P><R><V><T><K><L><A><C><L><D><S><Y><I><I><E><I><L><I><V><V><N><S><G><I><L><S><L><S><T><F><S><L><L><V><S><S><Y><I><I><I><L><V><T><V><W><L><K><S><S><A><A><M><A><K><A><F><S><T><L><A><S><H><I><A><V><V><I><L><F><F><G><P><C><I><F><I><Y><V><W><P><F><T><I><S><P><L><D><K><F><L><A><I><F><Y><T><V><F><T><P><V><L><N><P><I><I><Y><T><L><R><N><R><D><M><K><A><A><V><R><K><I><V><N><H><Y><L><R><P><R><R><I><S><E><M><S><L><V><V><R><T><S><F><H>
Odorant receptor.<BOP>
Q8NGD3
P05181
CP2E1_HUMAN
Cytochrome P450-J
Homo
<M><S><A><L><G><V><T><V><A><L><L><V><W><A><A><F><L><L><L><V><S><M><W><R><Q><V><H><S><S><W><N><L><P><P><G><P><F><P><L><P><I><I><G><N><L><F><Q><L><E><L><K><N><I><P><K><S><F><T><R><L><A><Q><R><F><G><P><V><F><T><L><Y><V><G><S><Q><R><M><V><V><M><H><G><Y><K><A><V><K><E><A><L><L><D><Y><K><D><E><F><S><G><R><G><D><L><P><A><F><H><A><H><R><D><R><G><I><I><F><N><N><G><P><T><W><K><D><I><R><R><F><S><L><T><T><L><R><N><Y><G><M><G><K><Q><G><N><E><S><R><I><Q><R><E><A><H><F><L><L><E><A><L><R><K><T><Q><G><Q><P><F><D><P><T><F><L><I><G><C><A><P><C><N><V><I><A><D><I><L><F><R><K><H><F><D><Y><N><D><E><K><F><L><R><L><M><Y><L><F><N><E><N><F><H><L><L><S><T><P><W><L><Q><L><Y><N><N><F><P><S><F><L><H><Y><L><P><G><S><H><R><K><V><I><K><N><V><A><E><V><K><E><Y><V><S><E><R><V><K><E><H><H><Q><S><L><D><P><N><C><P><R><D><L><T><D><C><L><L><V><E><M><E><K><E><K><H><S><A><E><R><L><Y><T><M><D><G><I><T><V><T><V><A><D><L><F><F><A><G><T><E><T><T><S><T><T><L><R><Y><G><L><L><I><L><M><K><Y><P><E><I><E><E><K><L><H><E><E><I><D><R><V><I><G><P><S><R><I><P><A><I><K><D><R><Q><E><M><P><Y><M><D><A><V><V><H><E><I><Q><R><F><I><T><L><V><P><S><N><L><P><H><E><A><T><R><D><T><I><F><R><G><Y><L><I><P><K><G><T><V><V><V><P><T><L><D><S><V><L><Y><D><N><Q><E><F><P><D><P><E><K><F><K><P><E><H><F><L><N><E><N><G><K><F><K><Y><S><D><Y><F><K><P><F><S><T><G><K><R><V><C><A><G><E><G><L><A><R><M><E><L><F><L><L><L><C><A><I><L><Q><H><F><N><L><K><P><L><V><D><P><K><D><I><D><L><S><P><I><H><I><G><F><G><C><I><P><P><R><Y><K><L><C><V><I><P><R><S>
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids . May be involved in the oxidative metabolism of xenobiotics (Probable).<BOP>
P05181
O75489
NDUS3_HUMAN
NADH-ubiquinone oxidoreductase 30 kDa subunit
Homo
<M><A><A><A><A><V><A><R><L><W><W><R><G><I><L><G><A><S><A><L><T><R><G><T><G><R><P><S><V><L><L><L><P><V><R><R><E><S><A><G><A><D><T><R><P><T><V><R><P><R><N><D><V><A><H><K><Q><L><S><A><F><G><E><Y><V><A><E><I><L><P><K><Y><V><Q><Q><V><Q><V><S><C><F><N><E><L><E><V><C><I><H><P><D><G><V><I><P><V><L><T><F><L><R><D><H><T><N><A><Q><F><K><S><L><V><D><L><T><A><V><D><V><P><T><R><Q><N><R><F><E><I><V><Y><N><L><L><S><L><R><F><N><S><R><I><R><V><K><T><Y><T><D><E><L><T><P><I><E><S><A><V><S><V><F><K><A><A><N><W><Y><E><R><E><I><W><D><M><F><G><V><F><F><A><N><H><P><D><L><R><R><I><L><T><D><Y><G><F><E><G><H><P><F><R><K><D><F><P><L><S><G><Y><V><E><L><R><Y><D><D><E><V><K><R><V><V><A><E><P><V><E><L><A><Q><E><F><R><K><F><D><L><N><S><P><W><E><A><F><P><V><Y><R><Q><P><P><E><S><L><K><L><E><A><G><D><K><K><P><D><A><K>
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity and assembly of complex I .<BOP>
O75489
P80162
CXCL6_HUMAN
Small-inducible cytokine B6, N-processed variant 3
Homo
<M><S><L><P><S><S><R><A><A><R><V><P><G><P><S><G><S><L><C><A><L><L><A><L><L><L><L><L><T><P><P><G><P><L><A><S><A><G><P><V><S><A><V><L><T><E><L><R><C><T><C><L><R><V><T><L><R><V><N><P><K><T><I><G><K><L><Q><V><F><P><A><G><P><Q><C><S><K><V><E><V><V><A><S><L><K><N><G><K><Q><V><C><L><D><P><E><A><P><F><L><K><K><V><I><Q><K><I><L><D><S><G><N><K><K><N>
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).<BOP>
P80162
Q15392
DHC24_HUMAN
Seladin-1
Homo
<M><E><P><A><V><S><L><A><V><C><A><L><L><F><L><L><W><V><R><L><K><G><L><E><F><V><L><I><H><Q><R><W><V><F><V><C><L><F><L><L><P><L><S><L><I><F><D><I><Y><Y><Y><V><R><A><W><V><V><F><K><L><S><S><A><P><R><L><H><E><Q><R><V><R><D><I><Q><K><Q><V><R><E><W><K><E><Q><G><S><K><T><F><M><C><T><G><R><P><G><W><L><T><V><S><L><R><V><G><K><Y><K><K><T><H><K><N><I><M><I><N><L><M><D><I><L><E><V><D><T><K><K><Q><I><V><R><V><E><P><L><V><T><M><G><Q><V><T><A><L><L><T><S><I><G><W><T><L><P><V><L><P><E><L><D><D><L><T><V><G><G><L><I><M><G><T><G><I><E><S><S><S><H><K><Y><G><L><F><Q><H><I><C><T><A><Y><E><L><V><L><A><D><G><S><F><V><R><C><T><P><S><E><N><S><D><L><F><Y><A><V><P><W><S><C><G><T><L><G><F><L><V><A><A><E><I><R><I><I><P><A><K><K><Y><V><K><L><R><F><E><P><V><R><G><L><E><A><I><C><A><K><F><T><H><E><S><Q><R><Q><E><N><H><F><V><E><G><L><L><Y><S><L><D><E><A><V><I><M><T><G><V><M><T><D><E><A><E><P><S><K><L><N><S><I><G><N><Y><Y><K><P><W><F><F><K><H><V><E><N><Y><L><K><T><N><R><E><G><L><E><Y><I><P><L><R><H><Y><Y><H><R><H><T><R><S><I><F><W><E><L><Q><D><I><I><P><F><G><N><N><P><I><F><R><Y><L><F><G><W><M><V><P><P><K><I><S><L><L><K><L><T><Q><G><E><T><L><R><K><L><Y><E><Q><H><H><V><V><Q><D><M><L><V><P><M><K><C><L><Q><Q><A><L><H><T><F><Q><N><D><I><H><V><Y><P><I><W><L><C><P><F><I><L><P><S><Q><P><G><L><V><H><P><K><G><N><E><A><E><L><Y><I><D><I><G><A><Y><G><E><P><R><V><K><H><F><E><A><R><S><C><M><R><Q><L><E><K><F><V><R><S><V><H><G><F><Q><M><L><Y><A><D><C><Y><M><N><R><E><E><F><W><E><M><F><D><G><S><L><Y><H><K><L><R><E><K><L><G><C><Q><D><A><F><P><E><V><Y><D><K><I><C><K><A><A><R><H>
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis . In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress . Also protects against amyloid-beta peptide-induced apoptosis .<BOP>
Q15392
Q14197
ICT1_HUMAN
Mitochondrial large ribosomal subunit protein mL62
Homo
<M><A><A><T><R><C><L><R><W><G><L><S><R><A><G><V><W><L><L><P><P><P><A><R><C><P><R><R><A><L><H><K><Q><K><D><G><T><E><F><K><S><I><Y><S><L><D><K><L><Y><P><E><S><Q><G><S><D><T><A><W><R><V><P><N><G><A><K><Q><A><D><S><D><I><P><L><D><R><L><T><I><S><Y><C><R><S><S><G><P><G><G><Q><N><V><N><K><V><N><S><K><A><E><V><R><F><H><L><A><T><A><E><W><I><A><E><P><V><R><Q><K><I><A><I><T><H><K><N><K><I><N><R><L><G><E><L><I><L><T><S><E><S><S><R><Y><Q><F><R><N><L><A><D><C><L><Q><K><I><R><D><M><I><T><E><A><S><Q><T><P><K><E><P><T><K><E><D><V><K><L><H><R><I><R><I><E><N><M><N><R><E><R><L><R><Q><K><R><I><H><S><A><V><K><T><S><R><R><V><D><M><D>
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.<BOP>
Q14197
O75346
ZN253_HUMAN
Zinc finger protein 411
Homo
<M><G><P><L><Q><F><R><D><V><A><I><E><F><S><L><E><E><W><H><C><L><D><T><A><Q><R><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><F><L><G><I><V><V><S><K><P><D><L><V><T><C><L><E><Q><G><K><K><P><L><T><M><E><R><H><E><M><I><A><K><P><P><V><M><S><S><H><F><A><Q><D><L><W><P><E><N><I><Q><N><S><F><Q><I><G><M><L><R><R><Y><E><E><C><R><H><D><N><L><Q><L><K><K><G><C><K><S><V><G><E><H><K><V><H><K><G><G><Y><N><G><L><N><Q><C><L><T><T><T><Q><K><E><I><F><Q><C><D><K><Y><G><K><V><F><H><K><F><S><N><S><N><T><Y><K><T><R><H><T><G><I><N><L><F><K><C><I><I><C><G><K><A><F><K><R><S><S><T><L><T><T><H><K><K><I><H><T><G><E><K><P><Y><R><C><E><E><C><G><K><A><F><N><Q><S><A><N><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><R><C><E><E><C><G><K><A><F><K><Q><S><S><N><L><T><T><H><K><K><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><T><D><L><T><T><H><K><I><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><H><P><S><H><V><T><T><H><K><K><I><H><T><R><G><K><P><Y><N><C><E><E><C><G><K><S><F><K><H><C><S><N><L><T><I><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><H><L><S><S><H><L><T><T><H><K><I><L><H><T><G><E><K><P><Y><R><C><R><E><C><G><K><A><F><N><H><S><T><T><L><F><S><H><E><K><I><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><T><F><T><W><P><S><I><L><S><K><H><K><R><T><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><S><F><T><A><S><S><T><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><W><S><S><D><L><N><K><H><K><K><I><H><I><E><R><K><P><Y><I><V><K><N><V><T><D><L><L><N><V><P><P><L><L><I><S><I><R>
May function as a transcription factor. Seem to have a transcriptional repression activity.<BOP>
O75346
P31271
HXA13_HUMAN
Homeobox protein Hox-1J
Homo
<M><T><A><S><V><L><L><H><P><R><W><I><E><P><T><V><M><F><L><Y><D><N><G><G><G><L><V><A><D><E><L><N><K><N><M><E><G><A><A><A><A><A><A><A><A><A><A><A><A><A><A><G><A><G><G><G><G><F><P><H><P><A><A><A><A><A><G><G><N><F><S><V><A><A><A><A><A><A><A><A><A><A><A><A><N><Q><C><R><N><L><M><A><H><P><A><P><L><A><P><G><A><A><S><A><Y><S><S><A><P><G><E><A><P><P><S><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><S><S><S><G><G><P><G><P><A><G><P><A><G><A><E><A><A><K><Q><C><S><P><C><S><A><A><A><Q><S><S><S><G><P><A><A><L><P><Y><G><Y><F><G><S><G><Y><Y><P><C><A><R><M><G><P><H><P><N><A><I><K><S><C><A><Q><P><A><S><A><A><A><A><A><A><F><A><D><K><Y><M><D><T><A><G><P><A><A><E><E><F><S><S><R><A><K><E><F><A><F><Y><H><Q><G><Y><A><A><G><P><Y><H><H><H><Q><P><M><P><G><Y><L><D><M><P><V><V><P><G><L><G><G><P><G><E><S><R><H><E><P><L><G><L><P><M><E><S><Y><Q><P><W><A><L><P><N><G><W><N><G><Q><M><Y><C><P><K><E><Q><A><Q><P><P><H><L><W><K><S><T><L><P><D><V><V><S><H><P><S><D><A><S><S><Y><R><R><G><R><K><K><R><V><P><Y><T><K><V><Q><L><K><E><L><E><R><E><Y><A><T><N><K><F><I><T><K><D><K><R><R><R><I><S><A><T><T><N><L><S><E><R><Q><V><T><I><W><F><Q><N><R><R><V><K><E><K><K><V><I><N><K><L><K><T><T><S>
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP>
P31271
P21554
CNR1_HUMAN
CANN6
Homo
<M><K><S><I><L><D><G><L><A><D><T><T><F><R><T><I><T><T><D><L><L><Y><V><G><S><N><D><I><Q><Y><E><D><I><K><G><D><M><A><S><K><L><G><Y><F><P><Q><K><F><P><L><T><S><F><R><G><S><P><F><Q><E><K><M><T><A><G><D><N><P><Q><L><V><P><A><D><Q><V><N><I><T><E><F><Y><N><K><S><L><S><S><F><K><E><N><E><E><N><I><Q><C><G><E><N><F><M><D><I><E><C><F><M><V><L><N><P><S><Q><Q><L><A><I><A><V><L><S><L><T><L><G><T><F><T><V><L><E><N><L><L><V><L><C><V><I><L><H><S><R><S><L><R><C><R><P><S><Y><H><F><I><G><S><L><A><V><A><D><L><L><G><S><V><I><F><V><Y><S><F><I><D><F><H><V><F><H><R><K><D><S><R><N><V><F><L><F><K><L><G><G><V><T><A><S><F><T><A><S><V><G><S><L><F><L><T><A><I><D><R><Y><I><S><I><H><R><P><L><A><Y><K><R><I><V><T><R><P><K><A><V><V><A><F><C><L><M><W><T><I><A><I><V><I><A><V><L><P><L><L><G><W><N><C><E><K><L><Q><S><V><C><S><D><I><F><P><H><I><D><E><T><Y><L><M><F><W><I><G><V><T><S><V><L><L><L><F><I><V><Y><A><Y><M><Y><I><L><W><K><A><H><S><H><A><V><R><M><I><Q><R><G><T><Q><K><S><I><I><I><H><T><S><E><D><G><K><V><Q><V><T><R><P><D><Q><A><R><M><D><I><R><L><A><K><T><L><V><L><I><L><V><V><L><I><I><C><W><G><P><L><L><A><I><M><V><Y><D><V><F><G><K><M><N><K><L><I><K><T><V><F><A><F><C><S><M><L><C><L><L><N><S><T><V><N><P><I><I><Y><A><L><R><S><K><D><L><R><H><A><F><R><S><M><F><P><S><C><E><G><T><A><Q><P><L><D><N><S><M><G><D><S><D><C><L><H><K><H><A><N><N><A><A><S><V><H><R><A><A><E><S><C><I><K><S><T><V><K><I><A><K><V><T><M><S><V><S><T><D><T><S><A><E><A><L>
Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes.<BOP>
P21554
Q7Z4G1
COMD6_HUMAN
COMM domain-containing protein 6
Homo
<M><E><A><S><S><E><P><P><L><D><A><K><S><D><V><T><N><Q><L><V><D><F><Q><W><K><L><G><M><A><V><S><S><D><T><C><R><S><L><K><Y><P><Y><V><A><V><M><L><K><V><A><D><H><S><G><Q><V><K><T><K><C><F><E><M><T><I><P><Q><F><Q><N><F><Y><R><Q><F><K><E><I><A><A><V><I><E><T><V>
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.<BOP>
Q7Z4G1
Q9UEU0
VTI1B_HUMAN
Vti1-rp1
Homo
<M><A><S><S><A><A><S><S><E><H><F><E><K><L><H><E><I><F><R><G><L><H><E><D><L><Q><G><V><P><E><R><L><L><G><T><A><G><T><E><E><K><K><K><L><I><R><D><F><D><E><K><Q><Q><E><A><N><E><T><L><A><E><M><E><E><E><L><R><Y><A><P><L><S><F><R><N><P><M><M><S><K><L><R><N><Y><R><K><D><L><A><K><L><H><R><E><V><R><S><T><P><L><T><A><T><P><G><G><R><G><D><M><K><Y><G><I><Y><A><V><E><N><E><H><M><N><R><L><Q><S><Q><R><A><M><L><L><Q><G><T><E><S><L><N><R><A><T><Q><S><I><E><R><S><H><R><I><A><T><E><T><D><Q><I><G><S><E><I><I><E><E><L><G><E><Q><R><D><Q><L><E><R><T><K><S><R><L><V><N><T><S><E><N><L><S><K><S><R><K><I><L><R><S><M><S><R><K><V><T><T><N><K><L><L><L><S><I><I><I><L><L><E><L><A><I><L><G><G><L><V><Y><Y><K><F><F><R><S><H>
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.<BOP>
Q9UEU0
O95218
ZRAB2_HUMAN
Zinc finger, splicing
Homo
<M><S><T><K><N><F><R><V><S><D><G><D><W><I><C><P><D><K><K><C><G><N><V><N><F><A><R><R><T><S><C><N><R><C><G><R><E><K><T><T><E><A><K><M><M><K><A><G><G><T><E><I><G><K><T><L><A><E><K><S><R><G><L><F><S><A><N><D><W><Q><C><K><T><C><S><N><V><N><W><A><R><R><S><E><C><N><M><C><N><T><P><K><Y><A><K><L><E><E><R><T><G><Y><G><G><G><F><N><E><R><E><N><V><E><Y><I><E><R><E><E><S><D><G><E><Y><D><E><F><G><R><K><K><K><K><Y><R><G><K><A><V><G><P><A><S><I><L><K><E><V><E><D><K><E><S><E><G><E><E><E><D><E><D><E><D><L><S><K><Y><K><L><D><E><D><E><D><E><D><D><A><D><L><S><K><Y><N><L><D><A><S><E><E><E><D><S><N><K><K><K><S><N><R><R><S><R><S><K><S><R><S><S><H><S><R><S><S><S><R><S><S><S><P><S><S><S><R><S><R><S><R><S><R><S><R><S><S><S><S><S><Q><S><R><S><R><S><S><S><R><E><R><S><R><S><R><G><S><K><S><R><S><S><S><R><S><H><R><G><S><S><S><P><R><K><R><S><Y><S><S><S><S><S><S><P><E><R><N><R><K><R><S><R><S><R><S><S><S><S><G><D><R><K><K><R><R><T><R><S><R><S><P><E><R><R><H><R><S><S><S><G><S><S><H><S><G><S><R><S><S><S><K><K><K>
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.<BOP>
O95218
Q8NGW1
OR6B3_HUMAN
Olfactory receptor OR2-2
Homo
<M><S><G><E><N><V><T><R><V><G><T><F><I><L><V><G><F><P><T><A><P><G><L><Q><Y><L><L><F><L><L><F><L><L><T><Y><L><F><V><L><V><E><N><L><A><I><I><L><T><V><W><S><S><T><S><L><H><R><P><M><Y><Y><F><L><S><S><M><S><F><L><E><I><W><Y><V><S><D><I><T><P><K><M><L><E><G><F><L><L><Q><Q><K><R><I><S><F><V><G><C><M><T><Q><L><Y><F><F><S><S><L><V><C><T><E><C><V><L><L><A><S><M><A><Y><D><R><Y><V><A><I><C><H><P><L><R><Y><H><V><L><V><T><P><G><L><C><L><Q><L><V><G><F><S><F><V><S><G><F><T><I><S><M><I><K><V><C><F><I><S><S><V><T><F><C><G><S><N><V><L><N><H><F><F><C><D><I><S><P><I><L><K><L><A><C><T><D><F><S><T><A><E><L><V><D><F><I><L><A><F><I><I><L><V><F><P><L><L><A><T><M><L><S><Y><A><H><I><T><L><A><V><L><R><I><P><S><A><T><G><C><W><R><A><F><F><T><C><A><S><H><L><T><V><V><T><V><F><Y><T><A><L><L><F><M><Y><V><R><P><Q><A><I><D><S><R><S><S><N><K><L><I><S><V><L><Y><T><V><I><T><P><I><L><N><P><L><I><Y><C><L><R><N><K><E><F><K><N><A><L><K><K><A><F><G><L><T><S><C><A><V><E><G><R><L><S><S><L><L><E><L><H><L><Q><I><H><S><Q><P><L>
Odorant receptor.<BOP>
Q8NGW1
Q8IXH6
T53I2_HUMAN
p53-inducible protein U
Homo
<M><F><Q><R><L><S><S><L><F><F><S><T><P><S><P><P><E><D><P><D><C><P><R><A><F><V><S><E><E><D><E><V><D><G><W><L><I><I><D><L><P><D><S><Y><A><A><P><P><S><P><G><A><A><P><A><P><A><G><R><P><P><P><A><P><S><L><M><D><E><S><W><F><V><T><P><P><A><C><F><T><A><E><G><P><G><L><G><P><A><R><L><Q><S><S><P><L><E><D><L><L><I><E><H><P><S><M><S><V><Y><V><T><G><S><T><I><V><L><E><P><G><S><P><S><P><L><P><D><A><A><L><P><D><G><D><L><S><E><G><E><L><T><P><A><R><R><E><P><R><A><A><R><H><A><A><P><L><P><A><R><A><A><L><L><E><K><A><G><Q><V><R><R><L><Q><R><A><R><Q><R><A><E><R><H><A><L><S><A><K><A><V><Q><R><Q><N><R><A><R><E><S><R><P><R><R><S><K><N><Q><S><S><F><I><Y><Q><P><C><Q><R><Q><F><N><Y>
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.<BOP>
Q8IXH6
Q9UNL2
SSRG_HUMAN
Signal sequence receptor subunit gamma
Homo
<M><A><P><K><G><S><S><K><Q><Q><S><E><E><D><L><L><L><Q><D><F><S><R><N><L><S><A><K><S><S><A><L><F><F><G><N><A><F><I><V><S><A><I><P><I><W><L><Y><W><R><I><W><H><M><D><L><I><Q><S><A><V><L><Y><S><V><M><T><L><V><S><T><Y><L><V><A><F><A><Y><K><N><V><K><F><V><L><K><H><K><V><A><Q><K><R><E><D><A><V><S><K><E><V><T><R><K><L><S><E><A><D><N><R><K><M><S><R><K><E><K><D><E><R><I><L><W><K><K><N><E><V><A><D><Y><E><A><T><T><F><S><I><F><Y><N><N><T><L><F><L><V><V><V><I><V><A><S><F><F><I><L><K><N><F><N><P><T><V><N><Y><I><L><S><I><S><A><S><S><G><L><I><A><L><L><S><T><G><S><K>
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.<BOP>
Q9UNL2
Q9NYG2
ZDHC3_HUMAN
Zinc finger DHHC domain-containing protein 3
Homo
<M><M><L><I><P><T><H><H><F><R><N><I><E><R><K><P><E><Y><L><Q><P><E><K><C><V><P><P><P><Y><P><G><P><V><G><T><M><W><F><I><R><D><G><C><G><I><A><C><A><I><V><T><W><F><L><V><L><Y><A><E><F><V><V><L><F><V><M><L><I><P><S><R><D><Y><V><Y><S><I><I><N><G><I><V><F><N><L><L><A><F><L><A><L><A><S><H><C><R><A><M><L><T><D><P><G><A><V><P><K><G><N><A><T><K><E><F><I><E><S><L><Q><L><K><P><G><Q><V><V><Y><K><C><P><K><C><C><S><I><K><P><D><R><A><H><H><C><S><V><C><K><R><C><I><R><K><M><D><H><H><C><P><W><V><N><N><C><V><G><E><N><N><Q><K><Y><F><V><L><F><T><M><Y><I><A><L><I><S><L><H><A><L><I><M><V><G><F><H><F><L><H><C><F><E><E><D><W><T><K><C><S><S><F><S><P><P><T><T><V><I><L><L><I><L><L><C><F><E><G><L><L><F><L><I><F><T><S><V><M><F><G><T><Q><V><H><S><I><C><T><D><E><T><G><I><E><Q><L><K><K><E><E><R><R><W><A><K><K><T><K><W><M><N><M><K><A><V><F><G><H><P><F><S><L><G><W><A><S><P><F><A><T><P><D><Q><G><K><A><D><P><Y><Q><Y><V><V>
May also function as a calcium transporter.<BOP>
Q9NYG2
Q14442
PIGH_HUMAN
Phosphatidylinositol-glycan biosynthesis class H protein
Homo
<M><E><D><E><R><S><F><S><D><I><C><G><G><R><L><A><L><Q><R><R><Y><Y><S><P><S><C><R><E><F><C><L><S><C><P><R><L><S><L><R><S><L><T><A><V><T><C><T><V><W><L><A><A><Y><G><L><F><T><L><C><E><N><S><M><I><L><S><A><A><I><F><I><T><L><L><G><L><L><G><Y><L><H><F><V><K><I><D><Q><E><T><L><L><I><I><D><S><L><G><I><Q><M><T><S><S><Y><A><S><G><K><E><S><T><T><F><I><E><M><G><K><V><K><D><I><V><I><N><E><A><I><Y><M><Q><K><V><I><Y><Y><L><C><I><L><L><K><D><P><V><E><P><H><G><I><S><Q><V><V><P><V><F><Q><S><A><K><P><R><L><D><C><L><I><E><V><Y><R><S><C><Q><E><I><L><A><H><Q><K><A><T><S><T><S><P>
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.<BOP>
Q14442
O43159
RRP8_HUMAN
Nucleomethylin
Homo
<M><F><E><E><P><E><W><A><E><A><A><P><V><A><A><G><L><G><P><V><I><S><R><P><P><P><A><A><S><S><Q><N><K><G><S><K><R><R><Q><L><L><A><T><L><R><A><L><E><A><A><S><L><S><Q><H><P><P><S><L><C><I><S><D><S><E><E><E><E><E><E><R><K><K><K><C><P><K><K><A><S><F><A><S><A><S><A><E><V><G><K><K><G><K><K><K><C><Q><K><Q><G><P><P><C><S><D><S><E><E><E><V><E><R><K><K><K><C><H><K><Q><A><L><V><G><S><D><S><A><E><D><E><K><R><K><R><K><C><Q><K><H><A><P><I><N><S><A><Q><H><L><D><N><V><D><Q><T><G><P><K><A><W><K><G><S><T><T><N><D><P><P><K><Q><S><P><G><S><T><S><P><K><P><P><H><T><L><S><R><K><Q><W><R><N><R><Q><K><N><K><R><R><C><K><N><K><F><Q><P><P><Q><V><P><D><Q><A><P><A><E><A><P><T><E><K><T><E><V><S><P><V><P><R><T><D><S><H><E><A><R><A><G><A><L><R><A><R><M><A><Q><R><L><D><G><A><R><F><R><Y><L><N><E><Q><L><Y><S><G><P><S><S><A><A><Q><R><L><F><Q><E><D><P><E><A><F><L><L><Y><H><R><G><F><Q><S><Q><V><K><K><W><P><L><Q><P><V><D><R><I><A><R><D><L><R><Q><R><P><A><S><L><V><V><A><D><F><G><C><G><D><C><R><L><A><S><S><I><R><N><P><V><H><C><F><D><L><A><S><L><D><P><R><V><T><V><C><D><M><A><Q><V><P><L><E><D><E><S><V><D><V><A><V><F><C><L><S><L><M><G><T><N><I><R><D><F><L><E><E><A><N><R><V><L><K><P><G><G><L><L><K><V><A><E><V><S><S><R><F><E><D><V><R><T><F><L><R><A><V><T><K><L><G><F><K><I><V><S><K><D><L><T><N><S><H><F><F><L><F><D><F><Q><K><T><G><P><P><L><V><G><P><K><A><Q><L><S><G><L><Q><L><Q><P><C><L><Y><K><R><R>
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.<BOP>
O43159
Q13434
MKRN4_HUMAN
Zinc finger protein 127-like 1
Homo
<M><A><E><A><A><A><P><G><T><T><V><T><T><S><G><A><G><A><A><A><A><E><A><A><E><T><A><E><A><V><S><P><T><P><I><P><T><V><T><A><P><S><P><R><A><G><G><G><V><G><G><S><D><G><S><D><G><S><G><G><R><G><D><S><G><A><Y><D><G><S><G><A><C><G><G><S><D><A><C><D><G><S><G><D><S><S><G><D><S><W><T><K><Q><V><T><C><R><Y><F><K><Y><G><I><C><K><E><G><D><N><C><R><Y><S><H><D><L><S><D><R><L><C><G><V><V><C><K><Y><F><Q><R><G><C><C><V><Y><G><D><R><C><R><C><E><H><S><K><P><L><K><Q><E><E><A><T><A><T><E><L><T><T><K><S><S><L><A><A><S><S><S><L><S><S><I><V><G><P><L><V><E><M><N><T><N><E><A><E><S><R><N><S><N><F><A><T><V><V><A><G><S><E><D><W><A><N><A><I><E><F><V><P><G><Q><P><Y><C><G><R><T><V><P><S><C><T><E><A><P><L><Q><G><S><V><T><K><E><E><S><E><E><E><Q><T><A><V><E><T><K><K><Q><L><C><P><Y><A><A><V><G><Q><C><R><Y><G><E><N><C><V><Y><L><H><G><D><L><C><D><M><C><G><L><Q><V><L><H><P><M><D><A><A><Q><R><S><Q><H><I><Q><A><C><I><E><A><H><E><K><D><M><E><F><S><F><A><V><Q><R><S><K><D><K><V><C><G><I><C><M><E><V><V><Y><E><K><A><N><P><N><E><H><R><F><G><I><L><S><N><C><N><H><T><F><C><L><K><C><I><R><K><W><R><S><A><K><E><F><E><S><R><I><V><K><S><C><P><Q><C><R><I><T><S><N><F><V><I><P><S><E><Y><W><V><E><E><K><E><E><K><Q><K><L><I><Q><K><Y><K><E><A><M><S><N><K><A><C><K><Y><F><D><E><G><R><G><S><C><P><F><G><E><N><C><F><Y><K><H><M><Y><P><D><G><R><R><E><E><P><Q><R><Q><Q><V><G><T><S><S><R><N><P><G><Q><Q><R><N><H><F><W><E><F><F><E><E><G><A><N><S><N><P><F><D><D><E><E><E><A><V><T><F><E><L><G><E><M><L><L><M><L>
May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.<BOP>
Q13434
P22760
AAAD_HUMAN
Arylacetamide deacetylase
Homo
<M><G><R><K><S><L><Y><L><L><I><V><G><I><L><I><A><Y><Y><I><Y><T><P><L><P><D><N><V><E><E><P><W><R><M><M><W><I><N><A><H><L><K><T><I><Q><N><L><A><T><F><V><E><L><L><G><L><H><H><F><M><D><S><F><K><V><V><G><S><F><D><E><V><P><P><T><S><D><E><N><V><T><V><T><E><T><K><F><N><N><I><L><V><R><V><Y><V><P><K><R><K><S><E><A><L><R><R><G><L><F><Y><I><H><G><G><G><W><C><V><G><S><A><A><L><S><G><Y><D><L><L><S><R><W><T><A><D><R><L><D><A><V><V><V><S><T><N><Y><R><L><A><P><K><Y><H><F><P><I><Q><F><E><D><V><Y><N><A><L><R><W><F><L><R><K><K><V><L><A><K><Y><G><V><N><P><E><R><I><G><I><S><G><D><S><A><G><G><N><L><A><A><A><V><T><Q><Q><L><L><D><D><P><D><V><K><I><K><L><K><I><Q><S><L><I><Y><P><A><L><Q><P><L><D><V><D><L><P><S><Y><Q><E><N><S><N><F><L><F><L><S><K><S><L><M><V><R><F><W><S><E><Y><F><T><T><D><R><S><L><E><K><A><M><L><S><R><Q><H><V><P><V><E><S><S><H><L><F><K><F><V><N><W><S><S><L><L><P><E><R><F><I><K><G><H><V><Y><N><N><P><N><Y><G><S><S><E><L><A><K><K><Y><P><G><F><L><D><V><R><A><A><P><L><L><A><D><D><N><K><L><R><G><L><P><L><T><Y><V><I><T><C><Q><Y><D><L><L><R><D><D><G><L><M><Y><V><T><R><L><R><N><T><G><V><Q><V><T><H><N><H><V><E><D><G><F><H><G><A><F><S><F><L><G><L><K><I><S><H><R><L><I><N><Q><Y><I><E><W><L><K><E><N><L>
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.<BOP>
P22760
P0CI00
Z705B_HUMAN
Putative zinc finger protein 705B
Homo
<M><H><S><L><E><K><V><T><F><E><D><V><A><I><D><F><T><Q><E><E><W><D><M><M><D><T><S><K><R><K><L><Y><R><D><V><M><L><E><N><I><S><H><L><V><S><L><G><Y><Q><I><S><K><S><Y><I><I><L><Q><L><E><Q><G><K><E><L><W><W><E><G><R><V><F><L><Q><D><Q><N><P><D><R><E><S><A><L><K><K><K><H><M><I><S><M><H><P><I><I><R><K><D><T><S><T><S><M><T><M><E><N><S><L><I><L><E><D><P><F><E><Y><N><D><S><G><E><D><C><T><H><S><S><T><I><T><Q><C><L><L><T><H><S><G><K><K><P><C><V><S><K><Q><C><G><K><S><L><R><N><L><L><S><P><K><P><R><K><Q><I><H><T><K><G><K><S><Y><Q><C><N><L><C><E><K><A><Y><T><N><C><F><Y><L><R><R><H><K><M><T><H><T><G><E><R><P><Y><A><C><H><L><C><G><K><A><F><T><Q><C><S><H><L><R><R><H><E><K><T><H><T><G><E><R><P><Y><K><C><H><Q><C><G><K><A><F><I><Q><S><F><N><L><R><R><H><E><R><T><H><L><G><Q><K><C><Y><E><C><D><K><S><G><K><A><F><S><Q><S><S><G><F><R><G><N><K><I><I><H><I><G><E><K><P><P><A><C><L><L><C><G><K><A><F><S><L><S><S><D><L><R>
May be involved in transcriptional regulation.<BOP>
P0CI00
O15479
MAGB2_HUMAN
MAGE-B2 antigen
Homo
<M><P><R><G><Q><K><S><K><L><R><A><R><E><K><R><R><K><A><R><D><E><T><R><G><L><N><V><P><Q><V><T><E><A><E><E><E><E><A><P><C><C><S><S><S><V><S><G><G><A><A><S><S><S><P><A><A><G><I><P><Q><E><P><Q><R><A><P><T><T><A><A><A><A><A><A><G><V><S><S><T><K><S><K><K><G><A><K><S><H><Q><G><E><K><N><A><S><S><S><Q><A><S><T><S><T><K><S><P><S><E><D><P><L><T><R><K><S><G><S><L><V><Q><F><L><L><Y><K><Y><K><I><K><K><S><V><T><K><G><E><M><L><K><I><V><G><K><R><F><R><E><H><F><P><E><I><L><K><K><A><S><E><G><L><S><V><V><F><G><L><E><L><N><K><V><N><P><N><G><H><T><Y><T><F><I><D><K><V><D><L><T><D><E><E><S><L><L><S><S><W><D><F><P><R><R><K><L><L><M><P><L><L><G><V><I><F><L><N><G><N><S><A><T><E><E><E><I><W><E><F><L><N><M><L><G><V><Y><D><G><E><E><H><S><V><F><G><E><P><W><K><L><I><T><K><D><L><V><Q><E><K><Y><L><E><Y><K><Q><V><P><S><S><D><P><P><R><F><Q><F><L><W><G><P><R><A><Y><A><E><T><S><K><M><K><V><L><E><F><L><A><K><V><N><G><T><T><P><C><A><F><P><T><H><Y><E><E><A><L><K><D><E><E><K><A><G><V>
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.<BOP>
O15479
A0A0B4J263
TVA39_HUMAN
T cell receptor alpha variable 39
Homo
<M><K><K><L><L><A><M><I><L><W><L><Q><L><D><R><L><S><G><E><L><K><V><E><Q><N><P><L><F><L><S><M><Q><E><G><K><N><Y><T><I><Y><C><N><Y><S><T><T><S><D><R><L><Y><W><Y><R><Q><D><P><G><K><S><L><E><S><L><F><V><L><L><S><N><G><A><V><K><Q><E><G><R><L><M><A><S><L><D><T><K><A><R><L><S><T><L><H><I><T><A><A><V><H><D><L><S><A><T><Y><F><C><A><V><D>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0B4J263
P60985
KTDAP_HUMAN
Keratinocyte differentiation-associated protein
Homo
<M><K><I><P><V><L><P><A><V><V><L><L><S><L><L><V><L><H><S><A><Q><G><A><T><L><G><G><P><E><E><E><S><T><I><E><N><Y><A><S><R><P><E><A><F><N><T><P><F><L><N><I><D><K><L><R><S><A><F><K><A><D><E><F><L><N><W><H><A><L><F><E><S><I><K><R><K><L><P><F><L><N><W><D><A><F><P><K><L><K><G><L><R><S><A><T><P><D><A><Q>
May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.<BOP>
P60985
Q92556
ELMO1_HUMAN
Protein ced-12 homolog
Homo
<M><P><P><P><A><D><I><V><K><V><A><I><E><W><P><G><A><Y><P><K><L><M><E><I><D><Q><K><K><P><L><S><A><I><I><K><E><V><C><D><G><W><S><L><A><N><H><E><Y><F><A><L><Q><H><A><D><S><S><N><F><Y><I><T><E><K><N><R><N><E><I><K><N><G><T><I><L><R><L><T><T><S><P><A><Q><N><A><Q><Q><L><H><E><R><I><Q><S><S><S><M><D><A><K><L><E><A><L><K><D><L><A><S><L><S><R><D><V><T><F><A><Q><E><F><I><N><L><D><G><I><S><L><L><T><Q><M><V><E><S><G><T><E><R><Y><Q><K><L><Q><K><I><M><K><P><C><F><G><D><M><L><S><F><T><L><T><A><F><V><E><L><M><D><H><G><I><V><S><W><D><T><F><S><V><A><F><I><K><K><I><A><S><F><V><N><K><S><A><I><D><I><S><I><L><Q><R><S><L><A><I><L><E><S><M><V><L><N><S><H><D><L><Y><Q><K><V><A><Q><E><I><T><I><G><Q><L><I><P><H><L><Q><G><S><D><Q><E><I><Q><T><Y><T><I><A><V><I><N><A><L><F><L><K><A><P><D><E><R><R><Q><E><M><A><N><I><L><A><Q><K><Q><L><R><S><I><I><L><T><H><V><I><R><A><Q><R><A><I><N><N><E><M><A><H><Q><L><Y><V><L><Q><V><L><T><F><N><L><L><E><D><R><M><M><T><K><M><D><P><Q><D><Q><A><Q><R><D><I><I><F><E><L><R><R><I><A><F><D><A><E><S><E><P><N><N><S><S><G><S><M><E><K><R><K><S><M><Y><T><R><D><Y><K><K><L><G><F><I><N><H><V><N><P><A><M><D><F><T><Q><T><P><P><G><M><L><A><L><D><N><M><L><Y><F><A><K><H><H><Q><D><A><Y><I><R><I><V><L><E><N><S><S><R><E><D><K><H><E><C><P><F><G><R><S><S><I><E><L><T><K><M><L><C><E><I><L><K><V><G><E><L><P><S><E><T><C><N><D><F><H><P><M><F><F><T><H><D><R><S><F><E><E><F><F><C><I><C><I><Q><L><L><N><K><T><W><K><E><M><R><A><T><S><E><D><F><N><K><V><M><Q><V><V><K><E><Q><V><M><R><A><L><T><T><K><P><S><S><L><D><Q><F><K><S><K><L><Q><N><L><S><Y><T><E><I><L><K><I><R><Q><S><E><R><M><N><Q><E><D><F><Q><S><R><P><I><L><E><L><K><E><K><I><Q><P><E><I><L><E><L><I><K><Q><Q><R><L><N><R><L><V><E><G><T><C><F><R><K><L><N><A><R><R><R><Q><D><K><F><W><Y><C><R><L><S><P><N><H><K><V><L><H><Y><G><D><L><E><E><S><P><Q><G><E><V><P><H><D><S><L><Q><D><K><L><P><V><A><D><I><K><A><V><V><T><G><K><D><C><P><H><M><K><E><K><G><A><L><K><Q><N><K><E><V><L><E><L><A><F><S><I><L><Y><D><S><N><C><Q><L><N><F><I><A><P><D><K><H><E><Y><C><I><W><T><D><G><L><N><A><L><L><G><K><D><M><M><S><D><L><T><R><N><D><L><D><T><L><L><S><M><E><I><K><L><R><L><L><D><L><E><N><I><Q><I><P><D><A><P><P><P><I><P><K><E><P><S><N><Y><D><F><V><Y><D><C><N>
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.<BOP>
Q92556
Q8TF27
AGA11_HUMAN
Centaurin-gamma-like protein KIAA1975
Homo
<M><T><I><I><S><V><T><L><E><I><H><H><H><I><T><E><R><D><A><D><R><S><L><T><I><L><D><E><Q><L><Y><S><F><A><F><S><T><V><H><I><T><K><K><R><N><G><G><G><S><L><N><N><Y><S><S><S><I><P><L><T><P><S><T><S><Q><E><D><L><Y><F><S><V><P><P><T><A><N><T><P><T><P><I><C><K><Q><S><M><G><W><S><N><L><F><T><S><E><K><G><S><D><P><D><K><G><R><K><A><L><E><S><H><A><D><T><I><G><S><G><R><A><I><P><I><K><Q><G><M><L><L><K><R><S><G><K><W><L><K><T><W><K><K><K><Y><V><T><L><C><S><N><G><V><L><T><Y><Y><S><S><L><G><D><Y><M><K><N><I><H><K><K><E><I><D><L><R><T><S><T><I><K><V><P><G><K><W><P><S><L><A><T><S><A><C><A><P><I><S><S><S><K><S><N><G><L><S><K><D><M><E><A><L><H><M><S><A><N><S><D><I><G><L><G><D><S><I><C><F><S><P><S><I><S><S><T><T><S><P><K><L><N><L><P><P><S><P><H><A><N><K><K><K><H><L><K><K><K><S><T><N><N><L><K><D><D><G><L><S><S><T><A><E><E><E><E><E><K><F><M><I><V><S><V><T><G><Q><T><C><H><F><K><A><T><T><Y><E><E><R><D><A><W><V><Q><A><I><Q><S><Q><I><L><A><S><L><Q><S><C><E><S><S><K><S><K><S><Q><L><T><S><Q><S><E><A><M><A><L><Q><S><I><Q><N><M><R><G><N><S><H><C><V><D><C><E><T><Q><N><P><K><W><A><S><L><N><L><G><V><L><M><C><I><E><C><S><G><I><H><R><S><L><G><T><R><L><S><R><V><R><S><L><E><L><D><D><W><P><V><E><L><R><K><V><M><S><S><I><G><N><D><L><A><N><S><I><W><E><G><S><S><Q><G><Q><T><K><P><S><I><E><S><T><R><E><E><K><E><R><W><I><R><S><K><Y><E><H><K><L><F><L><A><P><L><P><C><T><E><L><S><L><G><Q><H><L><L><R><A><T><A><D><E><D><L><R><T><A><I><L><L><L><A><H><G><S><R><E><E><V><N><E><T><C><G><E><G><D><G><C><T><A><L><H><L><A><C><R><K><G><N><V><V><L><A><Q><L><L><I><W><Y><G><V><D><V><M><A><R><D><A><H><G><N><T><A><L><T><Y><A><R><Q><A><S><S><Q><E><C><I><N><V><L><L><Q><Y><G><C><P><D><E><C><V>
Putative GTPase-activating protein.<BOP>
Q8TF27
P39905
GDNF_HUMAN
Astrocyte-derived trophic factor
Homo
<M><K><L><W><D><V><V><A><V><C><L><V><L><L><H><T><A><S><A><F><P><L><P><A><G><K><R><P><P><E><A><P><A><E><D><R><S><L><G><R><R><R><A><P><F><A><L><S><S><D><S><N><M><P><E><D><Y><P><D><Q><F><D><D><V><M><D><F><I><Q><A><T><I><K><R><L><K><R><S><P><D><K><Q><M><A><V><L><P><R><R><E><R><N><R><Q><A><A><A><A><N><P><E><N><S><R><G><K><G><R><R><G><Q><R><G><K><N><R><G><C><V><L><T><A><I><H><L><N><V><T><D><L><G><L><G><Y><E><T><K><E><E><L><I><F><R><Y><C><S><G><S><C><D><A><A><E><T><T><Y><D><K><I><L><K><N><L><S><R><N><R><R><L><V><S><D><K><V><G><Q><A><C><C><R><P><I><A><F><D><D><D><L><S><F><L><D><D><N><L><V><Y><H><I><L><R><K><H><S><A><K><R><C><G><C><I>
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.<BOP>
P39905
Q8N184
ZN567_HUMAN
Zinc finger protein 567
Homo
<M><A><Q><G><S><V><S><F><N><D><V><T><V><D><F><T><Q><E><E><W><Q><H><L><D><H><A><Q><K><T><L><Y><M><D><V><M><L><E><N><Y><C><H><L><I><S><V><G><C><H><M><T><K><P><D><V><I><L><K><L><E><R><G><E><E><P><W><T><S><F><A><G><H><T><C><L><E><E><N><W><K><A><E><D><F><L><V><K><F><K><E><H><Q><E><K><Y><S><R><S><V><V><S><I><N><H><K><K><L><V><K><E><K><S><K><I><Y><E><K><T><F><T><L><G><K><N><P><V><N><S><K><N><L><P><P><E><Y><D><T><H><G><R><I><L><K><N><V><S><E><L><I><I><S><N><L><N><P><A><R><K><R><L><S><E><Y><N><G><Y><G><K><S><L><L><S><T><K><Q><E><T><T><H><P><E><V><K><S><H><N><Q><S><A><R><A><F><S><H><N><E><V><L><M><Q><Y><Q><K><T><E><T><P><A><Q><S><F><G><Y><N><D><C><E><K><S><F><L><Q><R><G><G><L><I><T><H><S><R><P><Y><K><G><E><N><P><S><V><Y><N><K><K><R><R><A><T><N><I><E><K><K><H><T><C><N><E><C><G><K><S><F><C><R><K><S><V><L><I><L><H><Q><G><I><H><S><E><E><K><P><Y><Q><C><H><Q><C><G><N><A><F><R><R><K><S><Y><L><I><D><H><Q><R><T><H><T><G><E><K><P><F><V><C><N><E><C><G><K><S><F><R><L><K><T><A><L><T><D><H><Q><R><T><H><T><G><E><K><S><Y><E><C><L><Q><C><R><N><A><F><R><L><K><S><H><L><I><R><H><Q><R><T><H><T><G><E><K><P><Y><E><C><N><D><C><G><K><S><F><R><Q><K><T><T><L><S><L><H><Q><R><I><H><T><G><E><K><P><Y><I><C><K><E><C><G><K><S><F><H><Q><K><A><N><L><T><V><H><Q><R><T><H><T><G><E><K><P><Y><I><C><N><E><C><G><K><S><F><S><Q><K><T><T><L><A><L><H><E><K><T><H><N><E><E><K><P><Y><I><C><S><E><C><G><K><S><F><R><Q><K><T><T><L><V><A><H><Q><R><T><H><T><G><E><K><S><Y><E><C><P><H><C><G><K><A><F><R><M><K><S><Y><L><I><D><H><H><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><S><F><S><Q><K><T><N><L><N><L><H><Q><R><I><H><T><G><E><K><P><Y><V><C><N><E><C><G><K><S><F><R><Q><K><A><T><L><T><V><H><Q><K><I><H><T><G><Q><K><S><Y><E><C><P><Q><C><G><K><A><F><S><R><K><S><Y><L><I><H><H><Q><R><T><H><T><G><E><K><P><Y><K><C><S><E><C><G><K><C><F><R><Q><K><T><N><L><I><V><H><Q><R><T><H><T><G><E><K><P><Y><V><C><N><E><C><G><K><S><F><S><Y><K><R><N><L><I><V><H><Q><R><T><H><K><G><E><N><I><E><M><Q>
May be involved in transcriptional regulation.<BOP>
Q8N184
Q8NH95
O13C6_HUMAN
Putative olfactory receptor 13C7
Homo
<M><V><S><A><N><Q><T><A><S><V><T><E><F><I><L><L><G><L><S><A><H><P><K><L><E><K><T><F><F><V><L><I><L><L><M><Y><L><V><I><L><L><G><N><G><V><L><I><L><M><T><V><S><N><S><H><L><H><M><P><M><Y><F><F><L><G><N><L><S><F><L><D><I><C><Y><T><T><S><S><V><P><L><I><L><D><S><F><L><T><P><R><K><T><I><S><F><S><A><C><A><V><Q><M><F><L><S><F><A><M><G><A><T><E><C><V><L><L><S><M><M><A><F><D><R><Y><V><A><I><C><N><P><L><R><Y><P><V><V><M><S><K><A><A><Y><M><P><I><R><L><P><A><P><G>
Odorant receptor.<BOP>
Q8NH95
Q6ZSG1
RN165_HUMAN
RING finger protein 165
Homo
<M><V><L><V><H><V><G><Y><L><V><L><P><V><F><G><S><V><R><N><R><G><A><P><F><Q><R><S><Q><H><P><H><A><T><S><C><R><H><F><H><L><G><P><P><Q><P><Q><Q><L><A><P><D><F><P><L><A><H><P><V><Q><S><Q><P><G><L><S><A><H><M><A><P><A><H><Q><H><S><G><A><L><H><Q><S><L><T><P><L><P><T><L><Q><F><Q><D><V><T><G><P><S><F><L><P><Q><A><L><H><Q><Q><Y><L><L><Q><Q><Q><L><L><E><A><Q><H><R><R><L><V><S><H><P><R><R><S><Q><E><R><V><S><V><H><P><H><R><L><H><P><S><F><D><F><G><Q><L><Q><T><P><Q><P><R><Y><L><A><E><G><T><D><W><D><L><S><V><D><A><G><L><S><P><A><Q><F><Q><V><R><P><I><P><Q><H><Y><Q><H><Y><L><A><T><P><R><M><H><H><F><P><R><N><S><S><S><T><Q><M><V><V><H><E><I><R><N><Y><P><Y><P><Q><L><H><F><L><A><L><Q><G><L><N><P><S><R><H><T><S><A><V><R><E><S><Y><E><E><L><L><Q><L><E><D><R><L><G><N><V><T><R><G><A><V><Q><N><T><I><E><R><F><T><F><P><H><K><Y><K><K><R><R><P><Q><D><G><K><G><K><K><D><E><G><E><E><S><D><T><D><E><K><C><T><I><C><L><S><M><L><E><D><G><E><D><V><R><R><L><P><C><M><H><L><F><H><Q><L><C><V><D><Q><W><L><A><M><S><K><K><C><P><I><C><R><V><D><I><E><T><Q><L><G><A><D><S>
E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.<BOP>
Q6ZSG1
Q9NZL6
RGL1_HUMAN
Ral guanine nucleotide dissociation stimulator-like 1
Homo
<M><K><L><L><W><Q><A><K><M><S><S><I><Q><D><W><G><E><E><V><E><E><G><A><V><Y><H><V><T><L><K><R><V><Q><I><Q><Q><A><A><N><K><G><A><R><W><L><G><V><E><G><D><Q><L><P><P><G><H><T><V><S><Q><Y><E><T><C><K><I><R><T><I><K><A><G><T><L><E><K><L><V><E><N><L><L><T><A><F><G><D><N><D><F><T><Y><I><S><I><F><L><S><T><Y><R><G><F><A><S><T><K><E><V><L><E><L><L><L><D><R><Y><G><N><L><T><S><P><N><C><E><E><D><G><S><Q><S><S><S><E><S><K><M><V><I><R><N><A><I><A><S><I><L><R><A><W><L><D><Q><C><A><E><D><F><R><E><P><P><H><F><P><C><L><Q><K><L><L><D><Y><L><T><R><M><M><P><G><S><D><P><E><R><R><A><Q><N><L><L><E><Q><F><Q><K><Q><E><V><E><T><D><N><G><L><P><N><T><I><S><F><S><L><E><E><E><E><E><L><E><G><G><E><S><A><E><F><T><C><F><S><E><D><L><V><A><E><Q><L><T><Y><M><D><A><Q><L><F><K><K><V><V><P><H><H><C><L><G><C><I><W><S><R><R><D><K><K><E><N><K><H><L><A><P><T><I><R><A><T><I><S><Q><F><N><T><L><T><K><C><V><V><S><T><I><L><G><G><K><E><L><K><T><Q><Q><R><A><K><I><I><E><K><W><I><N><I><A><H><E><C><R><L><L><K><N><F><S><S><L><R><A><I><V><S><A><L><Q><S><N><S><I><Y><R><L><K><K><T><W><A><A><V><P><R><D><R><M><L><M><F><E><E><L><S><D><I><F><S><D><H><N><N><H><L><T><S><R><E><L><L><M><K><E><G><T><S><K><F><A><N><L><D><S><S><V><K><E><N><Q><K><R><T><Q><R><R><L><Q><L><Q><K><D><M><G><V><M><Q><G><T><V><P><Y><L><G><T><F><L><T><D><L><T><M><L><D><T><A><L><Q><D><Y><I><E><G><G><L><I><N><F><E><K><R><R><R><E><F><E><V><I><A><Q><I><K><L><L><Q><S><A><C><N><S><Y><C><M><T><P><D><Q><K><F><I><Q><W><F><Q><R><Q><Q><L><L><T><E><E><E><S><Y><A><L><S><C><E><I><E><A><A><A><D><A><S><T><T><S><P><K><P><R><K><S><M><V><K><R><L><S><L><L><F><L><G><S><D><M><I><T><S><P><T><P><T><K><E><Q><P><K><S><T><A><S><G><S><S><G><E><S><M><D><S><V><S><V><S><S><C><E><S><N><H><S><E><A><E><E><G><S><I><T><P><M><D><T><P><D><E><P><Q><K><K><L><S><E><S><S><S><S><C><S><S><I><H><S><M><D><T><N><S><S><G><M><S><S><L><I><N><P><L><S><S><P><P><S><C><N><N><N><P><K><I><H><K><R><S><V><S><V><T><S><I><T><S><T><V><L><P><P><V><Y><N><Q><Q><N><E><D><T><C><I><I><R><I><S><V><E><D><N><N><G><N><M><Y><K><S><I><M><L><T><S><Q><D><K><T><P><A><V><I><Q><R><A><M><L><K><H><N><L><D><S><D><P><A><E><E><Y><E><L><V><Q><V><I><S><E><D><K><E><L><V><I><P><D><S><A><N><V><F><Y><A><M><N><S><Q><V><N><F><D><F><I><L><R><K><K><N><S><M><E><E><Q><V><K><L><R><S><R><T><S><L><T><L><P><R><T><A><K><R><G><C><W><S><N><R><H><S><K><I><T><L>
Probable guanine nucleotide exchange factor.<BOP>
Q9NZL6
Q9HAW9
UD18_HUMAN
UDP-glucuronosyltransferase 1-H
Homo
<M><A><R><T><G><W><T><S><P><I><P><L><C><V><S><L><L><L><T><C><G><F><A><E><A><G><K><L><L><V><V><P><M><D><G><S><H><W><F><T><M><Q><S><V><V><E><K><L><I><L><R><G><H><E><V><V><V><V><M><P><E><V><S><W><Q><L><G><K><S><L><N><C><T><V><K><T><Y><S><T><S><Y><T><L><E><D><L><D><R><E><F><M><D><F><A><D><A><Q><W><K><A><Q><V><R><S><L><F><S><L><F><L><S><S><S><N><G><F><F><N><L><F><F><S><H><C><R><S><L><F><N><D><R><K><L><V><E><Y><L><K><E><S><S><F><D><A><V><F><L><D><P><F><D><A><C><G><L><I><V><A><K><Y><F><S><L><P><S><V><V><F><A><R><G><I><A><C><H><Y><L><E><E><G><A><Q><C><P><A><P><L><S><Y><V><P><R><I><L><L><G><F><S><D><A><M><T><F><K><E><R><V><R><N><H><I><M><H><L><E><E><H><L><F><C><Q><Y><F><S><K><N><A><L><E><I><A><S><E><I><L><Q><T><P><V><T><A><Y><D><L><Y><S><H><T><S><I><W><L><L><R><T><D><F><V><L><D><Y><P><K><P><V><M><P><N><M><I><F><I><G><G><I><N><C><H><Q><G><K><P><L><P><M><E><F><E><A><Y><I><N><A><S><G><E><H><G><I><V><V><F><S><L><G><S><M><V><S><E><I><P><E><K><K><A><M><A><I><A><D><A><L><G><K><I><P><Q><T><V><L><W><R><Y><T><G><T><R><P><S><N><L><A><N><N><T><I><L><V><K><W><L><P><Q><N><D><L><L><G><H><P><M><T><R><A><F><I><T><H><A><G><S><H><G><V><Y><E><S><I><C><N><G><V><P><M><V><M><M><P><L><F><G><D><Q><M><D><N><A><K><R><M><E><T><K><G><A><G><V><T><L><N><V><L><E><M><T><S><E><D><L><E><N><A><L><K><A><V><I><N><D><K><S><Y><K><E><N><I><M><R><L><S><S><L><H><K><D><R><P><V><E><P><L><D><L><A><V><F><W><V><E><F><V><M><R><H><K><G><A><P><H><L><R><P><A><A><H><D><L><T><W><Y><Q><Y><H><S><L><D><V><I><G><F><L><L><A><V><V><L><T><V><A><F><I><T><F><K><C><C><A><Y><G><Y><R><K><C><L><G><K><K><G><R><V><K><K><A><H><K><S><K><T><H>
Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.<BOP>
Q9HAW9
A6NET4
OR5K3_HUMAN
Olfactory receptor 5K3
Homo
<M><N><K><E><N><H><S><L><I><A><E><F><I><L><T><G><F><T><Y><H><P><K><L><K><T><V><L><F><V><V><F><F><A><I><Y><L><I><T><M><V><G><N><I><G><L><V><A><L><I><Y><I><E><Q><R><L><H><T><P><M><Y><I><F><L><G><N><L><V><L><M><D><S><C><C><S><S><A><I><T><P><K><M><L><E><N><F><F><S><E><D><K><R><I><T><L><Y><E><C><M><A><Q><F><Y><F><L><C><L><A><E><T><T><D><C><F><L><L><A><A><M><A><Y><D><C><Y><V><A><I><C><N><P><L><Q><Y><H><T><M><M><S><K><T><L><C><I><Q><M><T><A><G><A><Y><L><A><G><N><L><H><P><M><I><E><V><E><F><L><L><R><L><T><F><C><G><S><H><Q><I><N><H><F><F><C><D><V><L><P><L><Y><R><L><S><C><I><N><P><Y><I><N><E><L><V><L><F><I><L><A><G><S><I><Q><I><F><T><I><V><L><V><S><Y><F><Y><I><L><F><T><I><F><T><M><K><S><K><E><G><R><G><K><A><L><S><T><C><A><S><H><F><L><S><V><S><I><F><C><D><S><L><L><F><M><Y><A><R><P><G><A><V><N><E><G><D><K><D><I><P><V><A><I><F><Y><T><L><V><I><P><L><L><N><P><F><I><Y><S><L><R><N><K><E><V><I><N><I><M><K><K><I><M><K><K><R><K><F><C><H><I><L><K><Q><M><S><S><P><L><A><T>
Odorant receptor.<BOP>
A6NET4
Q07654
TFF3_HUMAN
Polypeptide P1.B
Homo
<M><A><A><R><A><L><C><M><L><G><L><V><L><A><L><L><S><S><S><S><A><E><E><Y><V><G><L><S><A><N><Q><C><A><V><P><A><K><D><R><V><D><C><G><Y><P><H><V><T><P><K><E><C><N><N><R><G><C><C><F><D><S><R><I><P><G><V><P><W><C><F><K><P><L><Q><E><A><E><C><T><F>
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).<BOP>
Q07654
Q9BRU2
TCAL7_HUMAN
Transcription elongation factor S-II protein-like 7
Homo
<M><Q><K><P><C><K><E><N><E><G><K><P><K><C><S><V><P><K><R><E><E><K><R><P><Y><G><E><F><E><R><Q><Q><T><E><G><N><F><R><Q><R><L><L><Q><S><L><E><E><F><K><E><D><I><D><Y><R><H><F><K><D><E><E><M><T><R><E><G><D><E><M><E><R><C><L><E><E><I><R><G><L><R><K><K><F><R><A><L><H><S><N><H><R><H><S><R><D><R><P><Y><P><I>
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.<BOP>
Q9BRU2
A6NHL2
TBAL3_HUMAN
Tubulin alpha chain-like 3
Homo
<M><R><E><C><L><S><I><H><I><G><Q><A><G><I><Q><I><G><D><A><C><W><E><L><Y><C><L><E><H><G><I><Q><P><N><G><V><V><L><D><T><Q><Q><D><Q><L><E><N><A><K><M><E><H><T><N><A><S><F><D><T><F><F><C><E><T><R><A><G><K><H><V><P><R><A><L><F><V><D><L><E><P><T><V><I><D><G><I><R><T><G><Q><H><R><S><L><F><H><P><E><Q><L><L><S><G><K><E><D><A><A><N><N><Y><A><R><G><R><Y><S><V><G><S><E><V><I><D><L><V><L><E><R><T><R><K><L><A><E><Q><C><G><G><L><Q><G><F><L><I><F><R><S><F><G><G><G><T><G><S><G><F><T><S><L><L><M><E><R><L><T><G><E><Y><S><R><K><T><K><L><E><F><S><V><Y><P><A><P><R><I><S><T><A><V><V><E><P><Y><N><S><V><L><T><T><H><S><T><T><E><H><T><D><C><T><F><M><V><D><N><E><A><V><Y><D><I><C><H><R><K><L><G><V><E><C><P><S><H><A><S><I><N><R><L><V><V><Q><V><V><S><S><I><T><A><S><L><R><F><E><G><P><L><N><V><D><L><I><E><F><Q><T><N><L><V><P><Y><P><R><I><H><F><P><M><T><A><F><A><P><I><V><S><A><D><K><A><Y><H><E><Q><F><S><V><S><D><I><T><T><A><C><F><E><S><S><N><Q><L><V><K><C><D><P><R><L><G><K><Y><M><A><C><C><L><L><Y><R><G><D><V><V><P><K><E><V><N><A><A><I><A><A><T><K><S><R><H><S><V><Q><F><V><D><W><C><P><T><G><F><K><V><G><I><N><N><R><P><P><T><V><M><P><G><G><D><L><A><K><V><H><R><S><I><C><M><L><S><N><T><T><A><I><V><E><A><W><A><R><L><D><H><K><F><D><L><M><Y><A><K><R><A><F><L><H><W><Y><L><R><E><G><M><E><E><A><E><F><L><E><A><R><E><D><L><A><A><L><E><R><D><Y><E><E><V><A><Q><S><F>
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.<BOP>
A6NHL2
Q15125
EBP_HUMAN
Emopamil-binding protein
Homo
<M><T><T><N><A><G><P><L><H><P><Y><W><P><Q><H><L><R><L><D><N><F><V><P><N><D><R><P><T><W><H><I><L><A><G><L><F><S><V><T><G><V><L><V><V><T><T><W><L><L><S><G><R><A><A><V><V><P><L><G><T><W><R><R><L><S><L><C><W><F><A><V><C><G><F><I><H><L><V><I><E><G><W><F><V><L><Y><Y><E><D><L><L><G><D><Q><A><F><L><S><Q><L><W><K><E><Y><A><K><G><D><S><R><Y><I><L><G><D><N><F><T><V><C><M><E><T><I><T><A><C><L><W><G><P><L><S><L><W><V><V><I><A><F><L><R><Q><H><P><L><R><F><I><L><Q><L><V><V><S><V><G><Q><I><Y><G><D><V><L><Y><F><L><T><E><H><R><D><G><F><Q><H><G><E><L><G><H><P><L><Y><F><W><F><Y><F><V><F><M><N><A><L><W><L><V><L><P><G><V><L><V><L><D><A><V><K><H><L><T><H><A><Q><S><T><L><D><A><K><A><T><K><A><K><S><K><K><N>
Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.<BOP>
Q15125
Q6NUT3
MFS12_HUMAN
Major facilitator superfamily domain-containing protein 12
Homo
<M><G><P><G><P><P><A><A><G><A><A><P><S><P><R><P><L><S><L><V><A><R><L><S><Y><A><V><G><H><F><L><N><D><L><C><A><S><M><W><F><T><Y><L><L><L><Y><L><H><S><V><R><A><Y><S><S><R><G><A><G><L><L><L><L><L><G><Q><V><A><D><G><L><C><T><P><L><V><G><Y><E><A><D><R><A><A><S><C><C><A><R><Y><G><P><R><K><A><W><H><L><V><G><T><V><C><V><L><L><S><F><P><F><I><F><S><P><C><L><G><C><G><A><A><T><P><E><W><A><A><L><L><Y><Y><G><P><F><I><V><I><F><Q><F><G><W><A><S><T><Q><I><S><H><L><S><L><I><P><E><L><V><T><N><D><H><E><K><V><E><L><T><A><L><R><Y><A><F><T><V><V><A><N><I><T><V><Y><G><A><A><W><L><L><L><H><L><Q><G><S><S><R><V><E><P><T><Q><D><I><S><I><S><D><Q><L><G><G><Q><D><V><P><V><F><R><N><L><S><L><L><V><V><G><V><G><A><V><F><S><L><L><F><H><L><G><T><R><E><R><R><R><P><H><A><E><E><P><G><E><H><T><P><L><L><A><P><A><T><A><Q><P><L><L><L><W><K><H><W><L><R><E><P><A><F><Y><Q><V><G><I><L><Y><M><T><T><R><L><I><V><N><L><S><Q><T><Y><M><A><M><Y><L><T><Y><S><L><H><L><P><K><K><F><I><A><T><I><P><L><V><M><Y><L><S><G><F><L><S><S><F><L><M><K><P><I><N><K><C><I><G><R><N><M><T><Y><F><S><G><L><L><V><I><L><A><F><A><A><W><V><A><L><A><E><G><L><G><V><A><V><Y><A><A><A><V><L><L><G><A><G><C><A><T><I><L><V><T><S><L><A><M><T><A><D><L><I><G><P><H><T><N><S><G><A><F><V><Y><G><S><M><S><F><L><D><K><V><A><N><G><L><A><V><M><A><I><Q><S><L><H><P><C><P><S><E><L><C><C><R><A><C><V><S><F><Y><H><W><A><M><V><A><V><T><G><G><V><G><V><A><A><A><L><C><L><C><S><L><L><L><W><P><T><R><L><R><R><W><D><R><D><A><R><P>
Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation . In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation . Also catalyzes import of cysteine into lysosomes in non-pigmented cells .<BOP>
Q6NUT3
O43760
SNG2_HUMAN
Cellugyrin
Homo
<M><E><S><G><A><Y><G><A><A><K><A><G><G><S><F><D><L><R><R><F><L><T><Q><P><Q><V><V><A><R><A><V><C><L><V><F><A><L><I><V><F><S><C><I><Y><G><E><G><Y><S><N><A><H><E><S><K><Q><M><Y><C><V><F><N><R><N><E><D><A><C><R><Y><G><S><A><I><G><V><L><A><F><L><A><S><A><F><F><L><V><V><D><A><Y><F><P><Q><I><S><N><A><T><D><R><K><Y><L><V><I><G><D><L><L><F><S><A><L><W><T><F><L><W><F><V><G><F><C><F><L><T><N><Q><W><A><V><T><N><P><K><D><V><L><V><G><A><D><S><V><R><A><A><I><T><F><S><F><F><S><I><F><S><W><G><V><L><A><S><L><A><Y><Q><R><Y><K><A><G><V><D><D><F><I><Q><N><Y><V><D><P><T><P><D><P><N><T><A><Y><A><S><Y><P><G><A><S><V><D><N><Y><Q><Q><P><P><F><T><Q><N><A><E><T><T><E><G><Y><Q><P><P><P><V><Y>
(Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication.<BOP>
O43760
Q6SPF0
SAMD1_HUMAN
Atherin
Homo
<M><A><G><P><P><A><L><P><P><P><E><T><A><A><A><A><T><T><A><A><A><A><S><S><S><A><A><S><P><H><Y><Q><E><W><I><L><D><T><I><D><S><L><R><S><R><K><A><R><P><D><L><E><R><I><C><R><M><V><R><R><R><H><G><P><E><P><E><R><T><R><A><E><L><E><K><L><I><Q><Q><R><A><V><L><R><V><S><Y><K><G><S><I><S><Y><R><N><A><A><R><V><Q><P><P><R><R><G><A><T><P><P><A><P><P><R><A><P><R><G><A><P><A><A><A><A><A><A><A><P><P><P><T><P><A><P><P><P><P><P><A><P><V><A><A><A><A><P><A><R><A><P><R><A><A><A><A><A><A><T><A><P><P><S><P><G><P><A><Q><P><G><P><R><A><Q><R><A><A><P><L><A><A><P><P><P><A><P><A><A><P><P><A><V><A><P><P><A><G><P><R><R><A><P><P><P><A><V><A><A><R><E><P><P><L><P><P><P><P><Q><P><P><A><P><P><Q><Q><Q><Q><P><P><P><P><Q><P><Q><P><P><P><E><G><G><A><V><R><A><G><G><A><A><R><P><V><S><L><R><E><V><V><R><Y><L><G><G><S><G><G><A><G><G><R><L><T><R><G><R><V><Q><G><L><L><E><E><E><A><A><A><R><G><R><L><E><R><T><R><L><G><A><L><A><L><P><R><G><D><R><P><G><R><A><P><P><A><A><S><A><R><P><S><R><S><K><R><G><G><E><E><R><V><L><E><K><E><E><E><E><D><D><D><E><D><E><D><E><E><D><D><V><S><E><G><S><E><V><P><E><S><D><R><P><A><G><A><Q><H><H><Q><L><N><G><E><R><G><P><Q><S><A><K><E><R><V><K><E><W><T><P><C><G><P><H><Q><G><Q><D><E><G><R><G><P><A><P><G><S><G><T><R><Q><V><F><S><M><A><A><M><N><K><E><G><G><T><A><S><V><A><T><G><P><D><S><P><S><P><V><P><L><P><P><G><K><P><A><L><P><G><A><D><G><T><P><F><G><C><P><P><G><R><K><E><K><P><S><D><P><V><E><W><T><V><M><D><V><V><E><Y><F><T><E><A><G><F><P><E><Q><A><T><A><F><Q><E><Q><E><I><D><G><K><S><L><L><L><M><Q><R><T><D><V><L><T><G><L><S><I><R><L><G><P><A><L><K><I><Y><E><H><H><I><K><V><L><Q><Q><G><H><F><E><D><D><D><P><D><G><F><L><G>
Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor . Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs . Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell .<BOP>
Q6SPF0
Q9Y3F1
TA6P_HUMAN
Putative TAP2-associated 6.5 kDa polypeptide
Homo
<M><S><L><L><W><T><P><Q><I><L><T><I><S><F><V><S><Y><I><L><S><L><F><P><S><P><F><P><S><C><Y><T><S><C><W><F><E><T><S><I><T><T><E><K><E><L><N><Q><Y><F><E><L><A><K><F><L><A>
May be associated with TAP2 isoform activity.<BOP>
Q9Y3F1
Q15080
NCF4_HUMAN
p40-phox
Homo
<M><A><V><A><Q><Q><L><R><A><E><S><D><F><E><Q><L><P><D><D><V><A><I><S><A><N><I><A><D><I><E><E><K><R><G><F><T><S><H><F><V><F><V><I><E><V><K><T><K><G><G><S><K><Y><L><I><Y><R><R><Y><R><Q><F><H><A><L><Q><S><K><L><E><E><R><F><G><P><D><S><K><S><S><A><L><A><C><T><L><P><T><L><P><A><K><V><Y><V><G><V><K><Q><E><I><A><E><M><R><I><P><A><L><N><A><Y><M><K><S><L><L><S><L><P><V><W><V><L><M><D><E><D><V><R><I><F><F><Y><Q><S><P><Y><D><S><E><Q><V><P><Q><A><L><R><R><L><R><P><R><T><R><K><V><K><S><V><S><P><Q><G><N><S><V><D><R><M><A><A><P><R><A><E><A><L><F><D><F><T><G><N><S><K><L><E><L><N><F><K><A><G><D><V><I><F><L><L><S><R><I><N><K><D><W><L><E><G><T><V><R><G><A><T><G><I><F><P><L><S><F><V><K><I><L><K><D><F><P><E><E><D><D><P><T><N><W><L><R><C><Y><Y><Y><E><D><T><I><S><T><I><K><D><I><A><V><E><E><D><L><S><S><T><P><L><L><K><D><L><L><E><L><T><R><R><E><F><Q><R><E><D><I><A><L><N><Y><R><D><A><E><G><D><L><V><R><L><L><S><D><E><D><V><A><L><M><V><R><Q><A><R><G><L><P><S><Q><K><R><L><F><P><W><K><L><H><I><T><Q><K><D><N><Y><R><V><Y><N><T><M><P>
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.<BOP>
Q15080
Q9BY50
SC11C_HUMAN
SPC21
Homo
<M><V><R><A><G><A><V><G><A><H><L><P><A><S><G><L><D><I><F><G><D><L><K><K><M><N><K><R><Q><L><Y><Y><Q><V><L><N><F><A><M><I><V><S><S><A><L><M><I><W><K><G><L><I><V><L><T><G><S><E><S><P><I><V><V><V><L><S><G><S><M><E><P><A><F><H><R><G><D><L><L><F><L><T><N><F><R><E><D><P><I><R><A><G><E><I><V><V><F><K><V><E><G><R><D><I><P><I><V><H><R><V><I><K><V><H><E><K><D><N><G><D><I><K><F><L><T><K><G><D><N><N><E><V><D><D><R><G><L><Y><K><E><G><Q><N><W><L><E><K><K><D><V><V><G><R><A><R><G><F><L><P><Y><V><G><M><V><T><I><I><M><N><D><Y><P><K><F><K><Y><A><L><L><A><V><M><G><A><Y><V><L><L><K><R><E><S>
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum . Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids .<BOP>
Q9BY50
P01834
IGKC_HUMAN
Ig kappa chain C region TI
Homo
<R><T><V><A><A><P><S><V><F><I><F><P><P><S><D><E><Q><L><K><S><G><T><A><S><V><V><C><L><L><N><N><F><Y><P><R><E><A><K><V><Q><W><K><V><D><N><A><L><Q><S><G><N><S><Q><E><S><V><T><E><Q><D><S><K><D><S><T><Y><S><L><S><S><T><L><T><L><S><K><A><D><Y><E><K><H><K><V><Y><A><C><E><V><T><H><Q><G><L><S><S><P><V><T><K><S><F><N><R><G><E><C>
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P01834
P42331
RHG25_HUMAN
Rho-type GTPase-activating protein 25
Homo
<M><S><L><K><L><P><R><N><W><D><F><N><L><K><V><E><A><A><K><I><A><R><S><R><S><V><M><T><G><E><Q><M><A><A><F><H><P><S><S><T><P><N><P><L><E><R><P><I><K><M><G><W><L><K><K><Q><R><S><I><V><K><N><W><Q><Q><R><Y><F><V><L><R><A><Q><Q><L><Y><Y><Y><K><D><E><E><D><T><K><P><Q><G><C><M><Y><L><P><G><C><T><I><K><E><I><A><T><N><P><E><E><A><G><K><F><V><F><E><I><I><P><A><S><W><D><Q><N><R><M><G><Q><D><S><Y><V><L><M><A><S><S><Q><A><E><M><E><E><W><V><K><F><L><R><R><V><A><G><T><P><C><G><V><F><G><Q><R><L><D><E><T><V><A><Y><E><Q><K><F><G><P><H><L><V><P><I><L><V><E><K><C><A><E><F><I><L><E><H><G><R><N><E><E><G><I><F><R><L><P><G><Q><D><N><L><V><K><Q><L><R><D><A><F><D><A><G><E><R><P><S><F><D><R><D><T><D><V><H><T><V><A><S><L><L><K><L><Y><L><R><D><L><P><E><P><V><V><P><W><S><Q><Y><E><G><F><L><L><C><G><Q><L><T><N><A><D><E><A><K><A><Q><Q><E><L><M><K><Q><L><S><I><L><P><R><D><N><Y><S><L><L><S><Y><I><C><R><F><L><H><E><I><Q><L><N><C><A><V><N><K><M><S><V><D><N><L><A><T><V><I><G><V><N><L><I><R><S><K><V><E><D><P><A><V><I><M><R><G><T><P><Q><I><Q><R><V><M><T><M><M><I><R><D><H><E><V><L><F><P><K><S><K><D><I><P><L><S><P><P><A><Q><K><N><D><P><K><K><A><P><V><A><R><S><S><V><G><W><D><A><T><E><D><L><R><I><S><R><T><D><S><F><S><S><M><T><S><D><S><D><T><T><S><P><T><G><Q><Q><P><S><D><A><F><P><E><D><S><S><K><V><P><R><E><K><P><G><D><W><K><M><Q><S><R><K><R><T><Q><T><L><P><N><R><K><C><F><L><T><S><A><F><Q><G><A><N><S><S><K><M><E><I><F><K><N><E><F><W><S><P><S><S><E><A><K><A><G><E><G><H><R><R><T><M><S><Q><D><L><R><Q><L><S><D><S><Q><R><T><S><T><Y><D><N><V><P><S><L><P><G><S><P><G><E><E><A><S><A><L><S><S><Q><A><C><D><S><K><G><D><T><L><A><S><P><N><S><E><T><G><P><G><K><K><N><S><G><E><E><E><I><D><S><L><Q><R><M><V><Q><E><L><R><K><E><I><E><T><Q><K><Q><M><Y><E><E><Q><I><K><N><L><E><K><E><N><Y><D><V><W><A><K><V><V><R><L><N><E><E><L><E><K><E><K><K><K><S><A><A><L><E><I><S><L><R><N><M><E><R><S><R><E><D><V><E><K><R><N><K><A><L><E><E><E><V><K><E><F><V><K><S><M><K><E><P><K><T><E><A>
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.<BOP>
P42331
P18850
ATF6A_HUMAN
Processed cyclic AMP-dependent transcription factor ATF-6 alpha
Homo
<M><G><E><P><A><G><V><A><G><T><M><E><S><P><F><S><P><G><L><F><H><R><L><D><E><D><W><D><S><A><L><F><A><E><L><G><Y><F><T><D><T><D><E><L><Q><L><E><A><A><N><E><T><Y><E><N><N><F><D><N><L><D><F><D><L><D><L><M><P><W><E><S><D><I><W><D><I><N><N><Q><I><C><T><V><K><D><I><K><A><E><P><Q><P><L><S><P><A><S><S><S><Y><S><V><S><S><P><R><S><V><D><S><Y><S><S><T><Q><H><V><P><E><E><L><D><L><S><S><S><S><Q><M><S><P><L><S><L><Y><G><E><N><S><N><S><L><S><S><A><E><P><L><K><E><D><K><P><V><T><G><P><R><N><K><T><E><N><G><L><T><P><K><K><K><I><Q><V><N><S><K><P><S><I><Q><P><K><P><L><L><L><P><A><A><P><K><T><Q><T><N><S><S><V><P><A><K><T><I><I><I><Q><T><V><P><T><L><M><P><L><A><K><Q><Q><P><I><I><S><L><Q><P><A><P><T><K><G><Q><T><V><L><L><S><Q><P><T><V><V><Q><L><Q><A><P><G><V><L><P><S><A><Q><P><V><L><A><V><A><G><G><V><T><Q><L><P><N><H><V><V><N><V><V><P><A><P><S><A><N><S><P><V><N><G><K><L><S><V><T><K><P><V><L><Q><S><T><M><R><N><V><G><S><D><I><A><V><L><R><R><Q><Q><R><M><I><K><N><R><E><S><A><C><Q><S><R><K><K><K><K><E><Y><M><L><G><L><E><A><R><L><K><A><A><L><S><E><N><E><Q><L><K><K><E><N><G><T><L><K><R><Q><L><D><E><V><V><S><E><N><Q><R><L><K><V><P><S><P><K><R><R><V><V><C><V><M><I><V><L><A><F><I><I><L><N><Y><G><P><M><S><M><L><E><Q><D><S><R><R><M><N><P><S><V><S><P><A><N><Q><R><R><H><L><L><G><F><S><A><K><E><A><Q><D><T><S><D><G><I><I><Q><K><N><S><Y><R><Y><D><H><S><V><S><N><D><K><A><L><M><V><L><T><E><E><P><L><L><Y><I><P><P><P><P><C><Q><P><L><I><N><T><T><E><S><L><R><L><N><H><E><L><R><G><W><V><H><R><H><E><V><E><R><T><K><S><R><R><M><T><N><N><Q><Q><K><T><R><I><L><Q><G><A><L><E><Q><G><S><N><S><Q><L><M><A><V><Q><Y><T><E><T><T><S><S><I><S><R><N><S><G><S><E><L><Q><V><Y><Y><A><S><P><R><S><Y><Q><D><F><F><E><A><I><R><R><R><G><D><T><F><Y><V><V><S><F><R><R><D><H><L><L><L><P><A><T><T><H><N><K><T><T><R><P><K><M><S><I><V><L><P><A><I><N><I><N><E><N><V><I><N><G><Q><D><Y><E><V><M><M><Q><I><D><C><Q><V><M><D><T><R><I><L><H><I><K><S><S><S><V><P><P><Y><L><R><D><Q><Q><R><N><Q><T><N><T><F><F><G><S><P><P><A><A><T><E><A><T><H><V><V><S><T><I><P><E><S><L><Q>
Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR . Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') . Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor . May play a role in foveal development and cone function in the retina .<BOP>
P18850
Q9NP99
TREM1_HUMAN
Triggering receptor expressed on monocytes 1
Homo
<M><R><K><T><R><L><W><G><L><L><W><M><L><F><V><S><E><L><R><A><A><T><K><L><T><E><E><K><Y><E><L><K><E><G><Q><T><L><D><V><K><C><D><Y><T><L><E><K><F><A><S><S><Q><K><A><W><Q><I><I><R><D><G><E><M><P><K><T><L><A><C><T><E><R><P><S><K><N><S><H><P><V><Q><V><G><R><I><I><L><E><D><Y><H><D><H><G><L><L><R><V><R><M><V><N><L><Q><V><E><D><S><G><L><Y><Q><C><V><I><Y><Q><P><P><K><E><P><H><M><L><F><D><R><I><R><L><V><V><T><K><G><F><S><G><T><P><G><S><N><E><N><S><T><Q><N><V><Y><K><I><P><P><T><T><T><K><A><L><C><P><L><Y><T><S><P><R><T><V><T><Q><A><P><P><K><S><T><A><D><V><S><T><P><D><S><E><I><N><L><T><N><V><T><D><I><I><R><V><P><V><F><N><I><V><I><L><L><A><G><G><F><L><S><K><S><L><V><F><S><V><L><F><A><V><T><L><R><S><F><V><P>
Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad.<BOP>
Q9NP99
Q02161
RHD_HUMAN
Rhesus D antigen
Homo
<M><S><S><K><Y><P><R><S><V><R><R><C><L><P><L><W><A><L><T><L><E><A><A><L><I><L><L><F><Y><F><F><T><H><Y><D><A><S><L><E><D><Q><K><G><L><V><A><S><Y><Q><V><G><Q><D><L><T><V><M><A><A><I><G><L><G><F><L><T><S><S><F><R><R><H><S><W><S><S><V><A><F><N><L><F><M><L><A><L><G><V><Q><W><A><I><L><L><D><G><F><L><S><Q><F><P><S><G><K><V><V><I><T><L><F><S><I><R><L><A><T><M><S><A><L><S><V><L><I><S><V><D><A><V><L><G><K><V><N><L><A><Q><L><V><V><M><V><L><V><E><V><T><A><L><G><N><L><R><M><V><I><S><N><I><F><N><T><D><Y><H><M><N><M><M><H><I><Y><V><F><A><A><Y><F><G><L><S><V><A><W><C><L><P><K><P><L><P><E><G><T><E><D><K><D><Q><T><A><T><I><P><S><L><S><A><M><L><G><A><L><F><L><W><M><F><W><P><S><F><N><S><A><L><L><R><S><P><I><E><R><K><N><A><V><F><N><T><Y><Y><A><V><A><V><S><V><V><T><A><I><S><G><S><S><L><A><H><P><Q><G><K><I><S><K><T><Y><V><H><S><A><V><L><A><G><G><V><A><V><G><T><S><C><H><L><I><P><S><P><W><L><A><M><V><L><G><L><V><A><G><L><I><S><V><G><G><A><K><Y><L><P><G><C><C><N><R><V><L><G><I><P><H><S><S><I><M><G><Y><N><F><S><L><L><G><L><L><G><E><I><I><Y><I><V><L><L><V><L><D><T><V><G><A><G><N><G><M><I><G><F><Q><V><L><L><S><I><G><E><L><S><L><A><I><V><I><A><L><M><S><G><L><L><T><G><L><L><L><N><L><K><I><W><K><A><P><H><E><A><K><Y><F><D><D><Q><V><F><W><K><F><P><H><L><A><V><G><F>
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.<BOP>
Q02161
P0DSN7
KVD37_HUMAN
Probable non-functional immunoglobulinn kappa variable 1D-37
Homo
<M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><V><P><G><A><R><C><D><I><Q><L><T><Q><S><P><S><S><L><S><A><S><V><G><D><R><V><T><I><T><C><R><V><S><Q><G><I><S><S><Y><L><N><W><Y><R><Q><K><P><G><K><V><P><K><L><L><I><Y><S><A><S><N><L><Q><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><P><E><D><V><A><T><Y><Y><G><Q><R><T><Y><N><A><P>
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection
P0DSN7
O76090
BEST1_HUMAN
Vitelliform macular dystrophy protein 2
Homo
<M><T><I><T><Y><T><S><Q><V><A><N><A><R><L><G><S><F><S><R><L><L><L><C><W><R><G><S><I><Y><K><L><L><Y><G><E><F><L><I><F><L><L><C><Y><Y><I><I><R><F><I><Y><R><L><A><L><T><E><E><Q><Q><L><M><F><E><K><L><T><L><Y><C><D><S><Y><I><Q><L><I><P><I><S><F><V><L><G><F><Y><V><T><L><V><V><T><R><W><W><N><Q><Y><E><N><L><P><W><P><D><R><L><M><S><L><V><S><G><F><V><E><G><K><D><E><Q><G><R><L><L><R><R><T><L><I><R><Y><A><N><L><G><N><V><L><I><L><R><S><V><S><T><A><V><Y><K><R><F><P><S><A><Q><H><L><V><Q><A><G><F><M><T><P><A><E><H><K><Q><L><E><K><L><S><L><P><H><N><M><F><W><V><P><W><V><W><F><A><N><L><S><M><K><A><W><L><G><G><R><I><R><D><P><I><L><L><Q><S><L><L><N><E><M><N><T><L><R><T><Q><C><G><H><L><Y><A><Y><D><W><I><S><I><P><L><V><Y><T><Q><V><V><T><V><A><V><Y><S><F><F><L><T><C><L><V><G><R><Q><F><L><N><P><A><K><A><Y><P><G><H><E><L><D><L><V><V><P><V><F><T><F><L><Q><F><F><F><Y><V><G><W><L><K><V><A><E><Q><L><I><N><P><F><G><E><D><D><D><D><F><E><T><N><W><I><V><D><R><N><L><Q><V><S><L><L><A><V><D><E><M><H><Q><D><L><P><R><M><E><P><D><M><Y><W><N><K><P><E><P><Q><P><P><Y><T><A><A><S><A><Q><F><R><R><A><S><F><M><G><S><T><F><N><I><S><L><N><K><E><E><M><E><F><Q><P><N><Q><E><D><E><E><D><A><H><A><G><I><I><G><R><F><L><G><L><Q><S><H><D><H><H><P><P><R><A><N><S><R><T><K><L><L><W><P><K><R><E><S><L><L><H><E><G><L><P><K><N><H><K><A><A><K><Q><N><V><R><G><Q><E><D><N><K><A><W><K><L><K><A><V><D><A><F><K><S><A><P><L><Y><Q><R><P><G><Y><Y><S><A><P><Q><T><P><L><S><P><T><P><M><F><F><P><L><E><P><S><A><P><S><K><L><H><S><V><T><G><I><D><T><K><D><K><S><L><K><T><V><S><S><G><A><K><K><S><F><E><L><L><S><E><S><D><G><A><L><M><E><H><P><E><V><S><Q><V><R><R><K><T><V><E><F><N><L><T><D><M><P><E><I><P><E><N><H><L><K><E><P><L><E><Q><S><P><T><N><I><H><T><T><L><K><D><H><M><D><P><Y><W><A><L><E><N><R><D><E><A><H><S>
Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.<BOP>
O76090
O60304
ZN500_HUMAN
Zinc finger protein with KRAB and SCAN domains 18
Homo
<M><A><T><V><P><G><L><Q><P><L><P><T><L><E><Q><D><L><E><Q><E><E><I><L><I><V><K><V><E><E><D><F><C><L><E><E><E><P><S><V><E><T><E><D><P><S><P><E><T><F><R><Q><L><F><R><L><F><C><Y><Q><E><V><A><G><P><R><E><A><L><S><R><L><W><E><L><C><C><R><W><L><R><P><E><L><R><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><V><L><P><G><E><I><Q><A><R><V><R><E><Q><Q><P><E><S><G><E><E><A><V><V><L><V><E><G><L><Q><R><K><P><R><K><H><R><Q><R><G><S><E><L><L><S><D><D><E><V><P><L><G><I><G><G><Q><F><L><K><H><Q><A><E><A><Q><P><E><D><L><S><L><E><E><E><A><R><F><S><S><Q><Q><P><P><A><Q><L><S><H><R><P><Q><R><G><P><L><L><W><P><E><R><G><P><P><A><P><R><H><Q><E><M><A><S><A><S><P><F><L><S><A><W><S><Q><V><P><V><N><L><E><D><V><A><V><Y><L><S><G><E><E><P><R><C><M><D><P><A><Q><R><D><A><P><L><E><N><E><G><P><G><I><Q><L><E><D><G><G><D><G><R><E><D><A><P><L><R><M><E><W><Y><R><V><L><S><A><R><C><Q><G><P><G><H><P><L><P><G><Q><R><P><A><P><V><R><G><L><V><R><P><D><Q><P><R><G><G><P><P><P><G><R><R><A><S><H><G><A><D><K><P><Y><T><C><P><E><C><G><K><G><F><S><K><T><S><H><L><T><K><H><Q><R><T><H><T><G><E><R><P><Y><K><C><L><V><C><G><K><G><F><S><D><R><S><N><F><S><T><H><Q><R><V><H><T><G><E><K><P><Y><P><C><P><E><C><G><K><R><F><S><Q><S><S><S><L><V><I><H><R><R><T><H><S><G><E><R><P><Y><A><C><T><Q><C><G><K><R><F><N><N><S><S><H><F><S><A><H><R><R><T><H><T><G><E><K><P><Y><T><C><P><A><C><G><R><G><F><R><R><G><T><D><L><H><K><H><Q><R><T><H><M><G><A><G><S><L><P><T><L><Q><P><V><A><P><G><G><P><G><A><K><A>
May be involved in transcriptional regulation.<BOP>
O60304
Q9H609
ZN576_HUMAN
Zinc finger protein 576
Homo
<M><E><D><P><N><P><E><E><N><M><K><Q><Q><D><S><P><K><E><R><S><P><Q><S><P><G><G><N><I><C><H><L><G><A><P><K><C><T><R><C><L><I><T><F><A><D><S><K><F><Q><E><R><H><M><K><R><E><H><P><A><D><F><V><A><Q><K><L><Q><G><V><L><F><I><C><F><T><C><A><R><S><F><P><S><S><K><A><L><I><T><H><Q><R><S><H><G><P><A><A><K><P><T><L><P><V><A><T><T><T><A><Q><P><T><F><P><C><P><D><C><G><K><T><F><G><Q><A><V><S><L><R><R><H><R><Q><M><H><E><V><R><A><P><P><G><T><F><A><C><T><E><C><G><Q><D><F><A><Q><E><A><G><L><H><Q><H><Y><I><R><H><A><R><G><E><L>
May be involved in transcriptional regulation.<BOP>
Q9H609
P25686
DNJB2_HUMAN
Heat shock protein J1
Homo
<M><A><S><Y><Y><E><I><L><D><V><P><R><S><A><S><A><D><D><I><K><K><A><Y><R><R><K><A><L><Q><W><H><P><D><K><N><P><D><N><K><E><F><A><E><K><K><F><K><E><V><A><E><A><Y><E><V><L><S><D><K><H><K><R><E><I><Y><D><R><Y><G><R><E><G><L><T><G><T><G><T><G><P><S><R><A><E><A><G><S><G><G><P><G><F><T><F><T><F><R><S><P><E><E><V><F><R><E><F><F><G><S><G><D><P><F><A><E><L><F><D><D><L><G><P><F><S><E><L><Q><N><R><G><S><R><H><S><G><P><F><F><T><F><S><S><S><F><P><G><H><S><D><F><S><S><S><S><F><S><F><S><P><G><A><G><A><F><R><S><V><S><T><S><T><T><F><V><Q><G><R><R><I><T><T><R><R><I><M><E><N><G><Q><E><R><V><E><V><E><E><D><G><Q><L><K><S><V><T><I><N><G><V><P><D><D><L><A><L><G><L><E><L><S><R><R><E><Q><Q><P><S><V><T><S><R><S><G><G><T><Q><V><Q><Q><T><P><A><S><C><P><L><D><S><D><L><S><E><D><E><D><L><Q><L><A><M><A><Y><S><L><S><E><M><E><A><A><G><K><K><P><A><G><G><R><E><A><Q><H><R><R><Q><G><R><P><K><A><Q><H><Q><D><P><G><L><G><G><T><Q><E><G><A><R><G><E><A><T><K><R><S><P><S><P><E><E><K><A><S><R><C><L><I><L>
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family . In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins . Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes . Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins .<BOP>
P25686
O95171
SCEL_HUMAN
Sciellin
Homo
<M><S><N><V><T><L><R><K><M><S><P><T><G><N><E><M><K><S><T><T><Q><G><T><T><R><K><Q><Q><D><F><H><E><V><N><K><R><R><T><F><L><Q><D><N><S><W><I><K><K><R><P><E><E><E><K><D><E><N><Y><G><R><V><V><L><N><R><H><N><S><H><D><A><L><D><R><K><V><N><E><R><D><V><P><K><A><T><I><S><R><Y><S><S><D><D><T><L><D><R><I><S><D><R><N><D><A><A><K><T><Y><K><A><N><T><L><D><N><Q><L><T><N><R><S><M><S><M><F><R><S><L><E><V><T><K><L><Q><P><G><G><S><L><N><A><N><T><S><N><T><I><A><S><T><S><A><T><T><P><V><K><K><K><R><Q><S><W><F><P><P><P><P><P><G><Y><N><A><S><S><S><T><G><T><R><R><R><E><P><G><V><H><P><P><I><P><P><K><P><S><S><P><V><S><S><P><N><Q><L><R><Q><D><N><R><Q><I><H><P><P><K><P><G><V><Y><T><E><T><N><R><S><A><E><R><N><I><R><S><Q><D><L><D><N><I><V><K><V><A><T><S><L><Q><R><S><D><K><G><E><E><L><D><N><L><I><K><M><N><K><S><L><N><R><N><Q><G><L><D><S><L><F><R><A><N><P><K><V><E><E><R><E><K><R><A><K><S><L><E><S><L><I><Y><M><S><T><R><T><D><K><D><G><K><G><I><Q><S><L><G><S><P><I><K><V><N><Q><R><T><D><K><N><E><K><G><R><Q><N><L><E><S><V><A><K><V><N><A><R><M><N><K><T><S><R><R><S><E><D><L><D><N><A><T><E><V><N><P><K><G><H><E><N><T><T><G><K><K><D><L><D><G><L><I><K><V><D><P><E><T><N><K><N><I><T><R><G><Q><S><L><D><N><L><I><K><V><T><P><E><V><K><R><S><N><Q><G><S><K><D><L><N><N><F><I><K><V><Y><P><G><T><E><K><S><T><E><G><G><Q><S><L><D><S><L><I><K><V><T><P><E><R><N><R><T><N><Q><G><N><Q><D><L><E><N><L><I><K><V><I><P><S><A><N><K><S><S><E><Q><G><L><D><E><H><I><N><V><S><P><K><A><V><K><N><T><D><G><K><Q><D><L><D><K><L><I><K><V><N><P><E><I><F><T><N><N><Q><R><N><Q><D><L><A><N><L><I><K><V><N><P><A><V><I><R><N><N><Q><S><Q><D><L><D><N><L><I><K><V><K><P><S><A><L><R><N><T><N><R><D><Q><N><L><E><N><L><I><E><V><N><S><H><V><S><E><N><K><N><G><S><S><N><T><G><A><K><Q><A><G><P><Q><D><T><V><V><Y><T><R><T><Y><V><E><N><S><K><S><P><K><D><G><Y><Q><E><N><I><S><G><K><Y><I><Q><T><V><Y><S><T><S><D><R><S><V><I><E><R><D><M><C><T><Y><C><R><K><P><L><G><V><E><T><K><M><I><L><D><E><L><Q><I><C><C><H><S><T><C><F><K><C><E><I><C><K><Q><P><L><E><N><L><Q><A><G><D><S><I><W><I><Y><R><Q><T><I><H><C><E><P><C><Y><S><K><I><M><A><K><W><I><P>
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.<BOP>
O95171
P60568
IL2_HUMAN
T-cell growth factor
Homo
<M><Y><R><M><Q><L><L><S><C><I><A><L><S><L><A><L><V><T><N><S><A><P><T><S><S><S><T><K><K><T><Q><L><Q><L><E><H><L><L><L><D><L><Q><M><I><L><N><G><I><N><N><Y><K><N><P><K><L><T><R><M><L><T><F><K><F><Y><M><P><K><K><A><T><E><L><K><H><L><Q><C><L><E><E><E><L><K><P><L><E><E><V><L><N><L><A><Q><S><K><N><F><H><L><R><P><R><D><L><I><S><N><I><N><V><I><V><L><E><L><K><G><S><E><T><T><F><M><C><E><Y><A><D><E><T><A><T><I><V><E><F><L><N><R><W><I><T><F><C><Q><S><I><I><S><T><L><T>
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance . Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG) . Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 . In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 . This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways . Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well . Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production . Plays a
P60568
Q9UHN1
DPOG2_HUMAN
PolG-beta
Homo
<M><R><S><R><V><A><V><R><A><C><H><K><V><C><R><C><L><L><S><G><F><G><G><R><V><D><A><G><Q><P><E><L><L><T><E><R><S><S><P><K><G><G><H><V><K><S><H><A><E><L><E><G><N><G><E><H><P><E><A><P><G><S><G><E><G><S><E><A><L><L><E><I><C><Q><R><R><H><F><L><S><G><S><K><Q><Q><L><S><R><D><S><L><L><S><G><C><H><P><G><F><G><P><L><G><V><E><L><R><K><N><L><A><A><E><W><W><T><S><V><V><V><F><R><E><Q><V><F><P><V><D><A><L><H><H><K><P><G><P><L><L><P><G><D><S><A><F><R><L><V><S><A><E><T><L><R><E><I><L><Q><D><K><E><L><S><K><E><Q><L><V><A><F><L><E><N><V><L><K><T><S><G><K><L><R><E><N><L><L><H><G><A><L><E><H><Y><V><N><C><L><D><L><V><N><K><R><L><P><Y><G><L><A><Q><I><G><V><C><F><H><P><V><F><D><T><K><Q><I><R><N><G><V><K><S><I><G><E><K><T><E><A><S><L><V><W><F><T><P><P><R><T><S><N><Q><W><L><D><F><W><L><R><H><R><L><Q><W><W><R><K><F><A><M><S><P><S><N><F><S><S><S><D><C><Q><D><E><E><G><R><K><G><N><K><L><Y><Y><N><F><P><W><G><K><E><L><I><E><T><L><W><N><L><G><D><H><E><L><L><H><M><Y><P><G><N><V><S><K><L><H><G><R><D><G><R><K><N><V><V><P><C><V><L><S><V><N><G><D><L><D><R><G><M><L><A><Y><L><Y><D><S><F><Q><L><T><E><N><S><F><T><R><K><K><N><L><H><R><K><V><L><K><L><H><P><C><L><A><P><I><K><V><A><L><D><V><G><R><G><P><T><L><E><L><R><Q><V><C><Q><G><L><F><N><E><L><L><E><N><G><I><S><V><W><P><G><Y><L><E><T><M><Q><S><S><L><E><Q><L><Y><S><K><Y><D><E><M><S><I><L><F><T><V><L><V><T><E><T><T><L><E><N><G><L><I><H><L><R><S><R><D><T><T><M><K><E><M><M><H><I><S><K><L><K><D><F><L><I><K><Y><I><S><S><A><K><N><V>
Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA.<BOP>
Q9UHN1
Q96T91
GPHA2_HUMAN
Thyrostimulin subunit alpha
Homo
<M><P><M><A><S><P><Q><T><L><V><L><Y><L><L><V><L><A><V><T><E><A><W><G><Q><E><A><V><I><P><G><C><H><L><H><P><F><N><V><T><V><R><S><D><R><Q><G><T><C><Q><G><S><H><V><A><Q><A><C><V><G><H><C><E><S><S><A><F><P><S><R><Y><S><V><L><V><A><S><G><Y><R><H><N><I><T><S><V><S><Q><C><C><T><I><S><G><L><K><K><V><K><V><Q><L><Q><C><V><G><S><R><R><E><E><L><E><I><F><T><A><R><A><C><Q><C><D><M><C><R><L><S><R><Y>
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production . Plays a central role in controlling thyroid cell metabolism .<BOP>
Q96T91
Q8N0Y3
OR4N4_HUMAN
Olfactory receptor OR15-5
Homo
<M><K><I><A><N><N><T><V><V><T><E><F><I><L><L><G><L><T><Q><S><Q><D><I><Q><L><L><V><F><V><L><I><L><I><F><Y><L><I><I><L><P><G><N><F><L><I><I><F><T><I><R><S><D><P><G><L><T><A><P><L><Y><L><F><L><G><N><L><A><F><L><D><A><S><Y><S><F><I><V><A><P><R><M><L><V><D><F><L><S><E><K><K><V><I><S><Y><R><G><C><I><T><Q><L><F><F><L><H><F><L><G><G><G><E><G><L><L><L><V><V><M><A><F><D><R><Y><I><A><I><C><R><P><L><H><C><S><T><V><M><N><P><R><A><C><Y><A><M><M><L><A><L><W><L><G><G><F><V><H><S><I><I><Q><V><V><L><I><L><R><L><P><F><C><G><P><N><Q><L><D><N><F><F><C><D><V><R><Q><V><I><K><L><A><C><T><D><M><F><V><V><E><L><L><M><V><F><N><S><G><L><M><T><L><L><C><F><L><G><L><L><A><S><Y><A><V><I><L><C><H><V><R><R><A><A><S><E><G><K><N><K><A><M><S><T><C><T><T><R><V><I><I><I><L><L><M><F><G><P><A><I><F><I><Y><M><C><P><F><R><A><L><P><A><D><K><M><V><S><L><F><H><T><V><I><F><P><L><M><N><P><M><I><Y><T><L><R><N><Q><E><V><K><T><S><M><K><R><L><L><S><R><H><V><V><C><Q><V><D><F><I><I><R><N>
Odorant receptor.<BOP>
Q8N0Y3
P21964
COMT_HUMAN
Catechol O-methyltransferase
Homo
<M><P><E><A><P><P><L><L><L><A><A><V><L><L><G><L><V><L><L><V><V><L><L><L><L><L><R><H><W><G><W><G><L><C><L><I><G><W><N><E><F><I><L><Q><P><I><H><N><L><L><M><G><D><T><K><E><Q><R><I><L><N><H><V><L><Q><H><A><E><P><G><N><A><Q><S><V><L><E><A><I><D><T><Y><C><E><Q><K><E><W><A><M><N><V><G><D><K><K><G><K><I><V><D><A><V><I><Q><E><H><Q><P><S><V><L><L><E><L><G><A><Y><C><G><Y><S><A><V><R><M><A><R><L><L><S><P><G><A><R><L><I><T><I><E><I><N><P><D><C><A><A><I><T><Q><R><M><V><D><F><A><G><V><K><D><K><V><T><L><V><V><G><A><S><Q><D><I><I><P><Q><L><K><K><K><Y><D><V><D><T><L><D><M><V><F><L><D><H><W><K><D><R><Y><L><P><D><T><L><L><L><E><E><C><G><L><L><R><K><G><T><V><L><L><A><D><N><V><I><C><P><G><A><P><D><F><L><A><H><V><R><G><S><S><C><F><E><C><T><H><Y><Q><S><F><L><E><Y><R><E><V><V><D><G><L><E><K><A><I><Y><K><G><P><G><S><E><A><G><P>
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.<BOP>
P21964
Q9BV47
DUS26_HUMAN
Novel amplified gene in thyroid anaplastic cancer
Homo
<M><C><P><G><N><W><L><W><A><S><M><T><F><M><A><R><F><S><R><S><S><S><R><S><P><V><R><T><R><G><T><L><E><E><M><P><T><V><Q><H><P><F><L><N><V><F><E><L><E><R><L><L><Y><T><G><K><T><A><C><N><H><A><D><E><V><W><P><G><L><Y><L><G><D><Q><D><M><A><N><N><R><R><E><L><R><R><L><G><I><T><H><V><L><N><A><S><H><S><R><W><R><G><T><P><E><A><Y><E><G><L><G><I><R><Y><L><G><V><E><A><H><D><S><P><A><F><D><M><S><I><H><F><Q><T><A><A><D><F><I><H><R><A><L><S><Q><P><G><G><K><I><L><V><H><C><A><V><G><V><S><R><S><A><T><L><V><L><A><Y><L><M><L><Y><H><H><L><T><L><V><E><A><I><K><K><V><K><D><H><R><G><I><I><P><N><R><G><F><L><R><Q><L><L><A><L><D><R><R><L><R><Q><G><L><E><A>
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).<BOP>
Q9BV47
Q9NUH8
TM14B_HUMAN
Transmembrane protein 14B
Homo
<M><E><K><P><L><F><P><L><V><P><L><H><W><F><G><F><G><Y><T><A><L><V><V><S><G><G><I><V><G><Y><V><K><T><G><S><V><P><S><L><A><A><G><L><L><F><G><S><L><A><G><L><G><A><Y><Q><L><Y><Q><D><P><R><N><V><W><G><F><L><A><A><T><S><V><T><F><V><G><V><M><G><M><R><S><Y><Y><Y><G><K><F><M><P><V><G><L><I><A><G><A><S><L><L><M><A><A><K><V><G><V><R><M><L><M><T><S><D>
Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.<BOP>
Q9NUH8
Q969S8
HDA10_HUMAN
Histone deacetylase 10
Homo
<M><G><T><A><L><V><Y><H><E><D><M><T><A><T><R><L><L><W><D><D><P><E><C><E><I><E><R><P><E><R><L><T><A><A><L><D><R><L><R><Q><R><G><L><E><Q><R><C><L><R><L><S><A><R><E><A><S><E><E><E><L><G><L><V><H><S><P><E><Y><V><S><L><V><R><E><T><Q><V><L><G><K><E><E><L><Q><A><L><S><G><Q><F><D><A><I><Y><F><H><P><S><T><F><H><C><A><R><L><A><A><G><A><G><L><Q><L><V><D><A><V><L><T><G><A><V><Q><N><G><L><A><L><V><R><P><P><G><H><H><G><Q><R><A><A><A><N><G><F><C><V><F><N><N><V><A><I><A><A><A><H><A><K><Q><K><H><G><L><H><R><I><L><V><V><D><W><D><V><H><H><G><Q><G><I><Q><Y><L><F><E><D><D><P><S><V><L><Y><F><S><W><H><R><Y><E><H><G><R><F><W><P><F><L><R><E><S><D><A><D><A><V><G><R><G><Q><G><L><G><F><T><V><N><L><P><W><N><Q><V><G><M><G><N><A><D><Y><V><A><A><F><L><H><L><L><L><P><L><A><F><E><F><D><P><E><L><V><L><V><S><A><G><F><D><S><A><I><G><D><P><E><G><Q><M><Q><A><T><P><E><C><F><A><H><L><T><Q><L><L><Q><V><L><A><G><G><R><V><C><A><V><L><E><G><G><Y><H><L><E><S><L><A><E><S><V><C><M><T><V><Q><T><L><L><G><D><P><A><P><P><L><S><G><P><M><A><P><C><Q><S><A><L><E><S><I><Q><S><A><R><A><A><Q><A><P><H><W><K><S><L><Q><Q><Q><D><V><T><A><V><P><M><S><P><S><S><H><S><P><E><G><R><P><P><P><L><L><P><G><G><P><V><C><K><A><A><A><S><A><P><S><S><L><L><D><Q><P><C><L><C><P><A><P><S><V><R><T><A><V><A><L><T><T><P><D><I><T><L><V><L><P><P><D><V><I><Q><Q><E><A><S><A><L><R><E><E><T><E><A><W><A><R><P><H><E><S><L><A><R><E><E><A><L><T><A><L><G><K><L><L><Y><L><L><D><G><M><L><D><G><Q><V><N><S><G><I><A><A><T><P><A><S><A><A><A><A><T><L><D><V><A><V><R><R><G><L><S><H><G><A><Q><R><L><L><C><V><A><L><G><Q><L><D><R><P><P><D><L><A><H><D><G><R><S><L><W><L><N><I><R><G><K><E><A><A><A><L><S><M><F><H><V><S><T><P><L><P><V><M><T><G><G><F><L><S><C><I><L><G><L><V><L><P><L><A><Y><G><F><Q><P><D><L><V><L><V><A><L><G><P><G><H><G><L><Q><G><P><H><A><A><L><L><A><A><M><L><R><G><L><A><G><G><R><V><L><A><L><L><E><E><N><S><T><P><Q><L><A><G><I><L><A><R><V><L><N><G><E><A><P><P><S><L><G><P><S><S><V><A><S><P><E><D><V><Q><A><L><M><Y><L><R><G><Q><L><E><P><Q><W><K><M><L><Q><C><H><P><H><L><V><A>
Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine . Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine . Histone deacetylase activity has been observed in vitro . Has also been shown to be involved in MSH2 deacetylation . The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak . May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells . May play a role in homologous recombination . May promote DNA mismatch repair .<BOP>
Q969S8
P35070
BTC_HUMAN
Betacellulin
Homo
<M><D><R><A><A><R><C><S><G><A><S><S><L><P><L><L><L><A><L><A><L><G><L><V><I><L><H><C><V><V><A><D><G><N><S><T><R><S><P><E><T><N><G><L><L><C><G><D><P><E><E><N><C><A><A><T><T><T><Q><S><K><R><K><G><H><F><S><R><C><P><K><Q><Y><K><H><Y><C><I><K><G><R><C><R><F><V><V><A><E><Q><T><P><S><C><V><C><D><E><G><Y><I><G><A><R><C><E><R><V><D><L><F><Y><L><R><G><D><R><G><Q><I><L><V><I><C><L><I><A><V><M><V><V><F><I><I><L><V><I><G><V><C><T><C><C><H><P><L><R><K><R><R><K><R><K><K><K><E><E><E><M><E><T><L><G><K><D><I><T><P><I><N><E><D><I><E><E><T><N><I><A>
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.<BOP>
P35070
Q7Z7L9
ZSCA2_HUMAN
Zinc finger protein 854
Homo
<M><M><A><A><D><I><P><R><V><T><T><P><L><S><S><L><V><Q><V><P><Q><E><E><D><R><Q><E><E><E><V><T><T><M><I><L><E><D><D><S><W><V><Q><E><A><V><L><Q><E><D><G><P><E><S><E><P><F><P><Q><S><A><G><K><G><G><P><Q><E><E><V><T><R><G><P><Q><G><A><L><G><R><L><R><E><L><C><R><R><W><L><R><P><E><V><H><T><K><E><Q><M><L><T><M><L><P><K><E><I><Q><A><W><L><Q><E><H><R><P><E><S><S><E><E><A><A><A><L><V><E><D><L><T><Q><T><L><Q><D><S><D><F><E><I><Q><S><E><N><G><E><N><C><N><Q><D><M><F><E><N><E><S><R><K><I><F><S><E><M><P><E><G><E><S><A><Q><H><S><D><G><E><S><D><F><E><R><D><A><G><I><Q><R><L><Q><G><H><S><P><G><E><D><H><G><E><V><V><S><Q><D><R><E><V><G><Q><L><I><G><L><Q><G><T><Y><L><G><E><K><P><Y><E><C><P><Q><C><G><K><T><F><S><R><K><S><H><L><I><T><H><E><R><T><H><T><G><E><K><Y><Y><K><C><D><E><C><G><K><S><F><S><D><G><S><N><F><S><R><H><Q><T><T><H><T><G><E><K><P><Y><K><C><R><D><C><G><K><S><F><S><R><S><A><N><L><I><T><H><Q><R><I><H><T><G><E><K><P><F><Q><C><A><E><C><G><K><S><F><S><R><S><P><N><L><I><A><H><Q><R><T><H><T><G><E><K><P><Y><S><C><P><E><C><G><K><S><F><G><N><R><S><S><L><N><T><H><Q><G><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><E><S><F><S><Y><N><S><N><L><I><R><H><Q><R><I><H><T><G><E><K><P><Y><K><C><T><D><C><G><Q><R><F><S><Q><S><S><A><L><I><T><H><R><R><T><H><T><G><E><K><P><Y><Q><C><S><E><C><G><K><S><F><S><R><S><S><N><L><A><T><H><R><R><T><H><M><V><E><K><P><Y><K><C><G><V><C><G><K><S><F><S><Q><S><S><S><L><I><A><H><Q><G><M><H><T><G><E><K><P><Y><E><C><L><T><C><G><E><S><F><S><W><S><S><N><L><L><K><H><Q><R><I><H><T><G><E><K><P><Y><K><C><S><E><C><G><K><C><F><S><Q><R><S><Q><L><V><V><H><Q><R><T><H><T><G><E><K><P><Y><K><C><L><M><C><G><K><S><F><S><R><G><S><I><L><V><M><H><Q><R><A><H><L><G><D><K><P><Y><R><C><P><E><C><G><K><G><F><S><W><N><S><V><L><I><I><H><Q><R><I><H><T><G><E><K><P><Y><K><C><P><E><C><G><K><G><F><S><N><S><S><N><F><I><T><H><Q><R><T><H><M><K><E><K><L><Y>
May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.<BOP>
Q7Z7L9
Q5MNZ6
WIPI3_HUMAN
WIPI49-like protein
Homo
<M><N><L><L><P><C><N><P><H><G><N><G><L><L><Y><A><G><F><N><Q><D><H><G><C><F><A><C><G><M><E><N><G><F><R><V><Y><N><T><D><P><L><K><E><K><E><K><Q><E><F><L><E><G><G><V><G><H><V><E><M><L><F><R><C><N><Y><L><A><L><V><G><G><G><K><K><P><K><Y><P><P><N><K><V><M><I><W><D><D><L><K><K><K><T><V><I><E><I><E><F><S><T><E><V><K><A><V><K><L><R><R><D><R><I><V><V><V><L><D><S><M><I><K><V><F><T><F><T><H><N><P><H><Q><L><H><V><F><E><T><C><Y><N><P><K><G><L><C><V><L><C><P><N><S><N><N><S><L><L><A><F><P><G><T><H><T><G><H><V><Q><L><V><D><L><A><S><T><E><K><P><P><V><D><I><P><A><H><E><G><V><L><S><C><I><A><L><N><L><Q><G><T><R><I><A><T><A><S><E><K><G><T><L><I><R><I><F><D><T><S><S><G><H><L><I><Q><E><L><R><R><G><S><Q><A><A><N><I><Y><C><I><N><F><N><Q><D><A><S><L><I><C><V><S><S><D><H><G><T><V><H><I><F><A><A><E><D><P><K><R><N><K><Q><S><S><L><A><S><A><S><F><L><P><K><Y><F><S><S><K><W><S><F><S><K><F><Q><V><P><S><G><S><P><C><I><C><A><F><G><T><E><P><N><A><V><I><A><I><C><A><D><G><S><Y><Y><K><F><L><F><N><P><K><G><E><C><I><R><D><V><Y><A><Q><F><L><E><M><T><D><D><K><L>
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation . Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 . In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway .<BOP>
Q5MNZ6
Q8IZF7
AGRF2_HUMAN
G-protein coupled receptor PGR20
Homo
<M><G><L><T><A><Y><G><N><R><R><V><Q><P><G><E><L><P><F><G><A><N><L><T><L><I><H><T><R><A><Q><P><V><I><C><S><K><L><L><L><T><K><R><V><S><P><I><S><F><F><L><S><K><F><Q><N><S><W><G><E><D><G><W><V><Q><L><D><Q><L><P><S><P><N><A><V><S><S><D><Q><V><H><C><S><A><G><C><T><H><R><K><C><G><W><A><A><S><K><S><K><E><K><V><P><A><R><P><H><G><V><C><D><G><V><C><T><D><Y><S><Q><C><T><Q><P><C><P><P><D><T><Q><G><N><M><G><F><S><C><R><Q><K><T><W><H><K><I><T><D><T><C><Q><T><L><N><A><L><N><I><F><E><E><D><S><R><L><V><Q><P><F><E><D><N><I><K><I><S><V><Y><T><G><K><S><E><T><I><T><D><M><L><L><Q><K><C><P><T><D><L><S><C><V><I><R><N><I><Q><Q><S><P><W><I><P><G><N><I><A><V><I><V><Q><L><L><H><N><I><S><T><A><I><W><T><G><V><D><E><A><K><M><Q><S><Y><S><T><I><A><N><H><I><L><N><S><K><S><I><S><N><W><T><F><I><P><D><R><N><S><S><Y><I><L><L><H><S><V><N><S><F><A><R><R><L><F><I><D><K><H><P><V><D><I><S><D><V><F><I><H><T><M><G><T><T><I><S><G><D><N><I><G><K><N><F><T><F><S><M><R><I><N><D><T><S><N><E><V><T><G><R><V><L><I><S><R><D><E><L><R><K><V><P><S><P><S><Q><V><I><S><I><A><F><P><T><I><G><A><I><L><E><A><S><L><L><E><N><V><T><V><N><G><L><V><L><S><A><I><L><P><K><E><L><K><R><I><S><L><I><F><E><K><I><S><K><S><E><E><R><R><T><Q><C><V><G><W><H><S><V><E><N><R><W><D><Q><Q><A><C><K><M><I><Q><E><N><S><Q><Q><A><V><C><K><C><R><P><S><K><L><F><T><S><F><S><I><L><M><S><P><H><I><L><E><S><L><I><L><T><Y><I><T><Y><V><G><L><G><I><S><I><C><S><L><I><L><C><L><S><I><E><V><L><V><W><S><Q><V><T><K><T><E><I><T><Y><L><R><H><V><C><I><V><N><I><A><A><T><L><L><M><A><D><V><W><F><I><V><A><S><F><L><S><G><P><I><T><H><H><K><G><C><V><A><A><T><F><F><V><H><F><F><Y><L><S><V><F><F><W><M><L><A><K><A><L><L><I><L><Y><G><I><M><I><V><F><H><T><L><P><K><S><V><L><V><A><S><L><F><S><V><G><Y><G><C><P><L><A><I><A><A><I><T><V><A><A><T><E><P><G><K><G><Y><L><R><P><E><I><C><W><L><N><W><D><M><T><K><A><L><L><A><F><V><I><P><A><L><A><I><V><V><V><N><L><I><T><V><T><L><V><I><V><K><T><Q><R><A><A><I><G><N><S><M><F><Q><E><V><R><A><I><V><R><I><S><K><N><I><A><I><L><T><P><L><L><G><L><T><W><G><F><G><V><A><T><V><I><D><D><R><S><L><A><F><H><I><I><F><S><L><L><N><A><F><Q><V><S><P><D><A><S><D><Q><V><Q><S><E><R><I><H><E><D><V><L>
Orphan receptor.<BOP>
Q8IZF7
O00232
PSD12_HUMAN
26S proteasome regulatory subunit p55
Homo
<M><A><D><G><G><S><E><R><A><D><G><R><I><V><K><M><E><V><D><Y><S><A><T><V><D><Q><R><L><P><E><C><A><K><L><A><K><E><G><R><L><Q><E><V><I><E><T><L><L><S><L><E><K><Q><T><R><T><A><S><D><M><V><S><T><S><R><I><L><V><A><V><V><K><M><C><Y><E><A><K><E><W><D><L><L><N><E><N><I><M><L><L><S><K><R><R><S><Q><L><K><Q><A><V><A><K><M><V><Q><Q><C><C><T><Y><V><E><E><I><T><D><L><P><I><K><L><R><L><I><D><T><L><R><M><V><T><E><G><K><I><Y><V><E><I><E><R><A><R><L><T><K><T><L><A><T><I><K><E><Q><N><G><D><V><K><E><A><A><S><I><L><Q><E><L><Q><V><E><T><Y><G><S><M><E><K><K><E><R><V><E><F><I><L><E><Q><M><R><L><C><L><A><V><K><D><Y><I><R><T><Q><I><I><S><K><K><I><N><T><K><F><F><Q><E><E><N><T><E><K><L><K><L><K><Y><Y><N><L><M><I><Q><L><D><Q><H><E><G><S><Y><L><S><I><C><K><H><Y><R><A><I><Y><D><T><P><C><I><Q><A><E><S><E><K><W><Q><Q><A><L><K><S><V><V><L><Y><V><I><L><A><P><F><D><N><E><Q><S><D><L><V><H><R><I><S><G><D><K><K><L><E><E><I><P><K><Y><K><D><L><L><K><L><F><T><T><M><E><L><M><R><W><S><T><L><V><E><D><Y><G><M><E><L><R><K><G><S><L><E><S><P><A><T><D><V><F><G><S><T><E><E><G><E><K><R><W><K><D><L><K><N><R><V><V><E><H><N><I><R><I><M><A><K><Y><Y><T><R><I><T><M><K><R><M><A><Q><L><L><D><L><S><V><D><E><S><E><A><F><L><S><N><L><V><V><N><K><T><I><F><A><K><V><D><R><L><A><G><I><I><N><F><Q><R><P><K><D><P><N><N><L><L><N><D><W><S><Q><K><L><N><S><L><M><S><L><V><N><K><T><T><H><L><I><A><K><E><E><M><I><H><N><L><Q>
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.<BOP>
O00232
P14778
IL1R1_HUMAN
Interleukin-1 receptor type 1, soluble form
Homo
<M><K><V><L><L><R><L><I><C><F><I><A><L><L><I><S><S><L><E><A><D><K><C><K><E><R><E><E><K><I><I><L><V><S><S><A><N><E><I><D><V><R><P><C><P><L><N><P><N><E><H><K><G><T><I><T><W><Y><K><D><D><S><K><T><P><V><S><T><E><Q><A><S><R><I><H><Q><H><K><E><K><L><W><F><V><P><A><K><V><E><D><S><G><H><Y><Y><C><V><V><R><N><S><S><Y><C><L><R><I><K><I><S><A><K><F><V><E><N><E><P><N><L><C><Y><N><A><Q><A><I><F><K><Q><K><L><P><V><A><G><D><G><G><L><V><C><P><Y><M><E><F><F><K><N><E><N><N><E><L><P><K><L><Q><W><Y><K><D><C><K><P><L><L><L><D><N><I><H><F><S><G><V><K><D><R><L><I><V><M><N><V><A><E><K><H><R><G><N><Y><T><C><H><A><S><Y><T><Y><L><G><K><Q><Y><P><I><T><R><V><I><E><F><I><T><L><E><E><N><K><P><T><R><P><V><I><V><S><P><A><N><E><T><M><E><V><D><L><G><S><Q><I><Q><L><I><C><N><V><T><G><Q><L><S><D><I><A><Y><W><K><W><N><G><S><V><I><D><E><D><D><P><V><L><G><E><D><Y><Y><S><V><E><N><P><A><N><K><R><R><S><T><L><I><T><V><L><N><I><S><E><I><E><S><R><F><Y><K><H><P><F><T><C><F><A><K><N><T><H><G><I><D><A><A><Y><I><Q><L><I><Y><P><V><T><N><F><Q><K><H><M><I><G><I><C><V><T><L><T><V><I><I><V><C><S><V><F><I><Y><K><I><F><K><I><D><I><V><L><W><Y><R><D><S><C><Y><D><F><L><P><I><K><A><S><D><G><K><T><Y><D><A><Y><I><L><Y><P><K><T><V><G><E><G><S><T><S><D><C><D><I><F><V><F><K><V><L><P><E><V><L><E><K><Q><C><G><Y><K><L><F><I><Y><G><R><D><D><Y><V><G><E><D><I><V><E><V><I><N><E><N><V><K><K><S><R><R><L><I><I><I><L><V><R><E><T><S><G><F><S><W><L><G><G><S><S><E><E><Q><I><A><M><Y><N><A><L><V><Q><D><G><I><K><V><V><L><L><E><L><E><K><I><Q><D><Y><E><K><M><P><E><S><I><K><F><I><K><Q><K><H><G><A><I><R><W><S><G><D><F><T><Q><G><P><Q><S><A><K><T><R><F><W><K><N><V><R><Y><H><M><P><V><Q><R><R><S><P><S><S><K><H><Q><L><L><S><P><A><T><K><E><K><L><Q><R><E><A><H><V><P><L><G>
Receptor for IL1A, IL1B and IL1RN . After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells .<BOP>
P14778
Q8N859
ZN713_HUMAN
Zinc finger protein 713
Homo
<M><P><S><Q><N><A><V><F><S><Q><E><G><N><M><E><E><E><E><M><N><D><G><S><Q><M><V><R><S><Q><E><S><L><T><F><Q><D><V><A><V><D><F><T><R><E><E><W><D><Q><L><Y><P><A><Q><K><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><A><L><G><Y><Q><L><C><K><P><E><V><I><A><Q><L><E><L><E><E><E><W><V><I><E><R><D><S><L><L><D><T><H><P><D><G><E><N><R><P><E><I><K><K><S><T><T><S><Q><N><I><S><D><E><N><Q><T><H><E><M><I><M><E><R><L><A><G><D><S><F><W><Y><S><I><L><G><G><L><W><D><F><D><Y><H><P><E><F><N><Q><E><N><H><K><R><Y><L><G><Q><V><T><L><T><H><K><K><I><T><Q><E><R><S><L><E><C><N><K><F><A><E><N><C><N><L><N><S><N><L><M><Q><Q><R><I><P><S><I><K><I><P><L><N><S><D><T><Q><G><N><S><I><K><H><N><S><D><L><I><Y><Y><Q><G><N><Y><V><R><E><T><P><Y><E><Y><S><E><C><G><K><I><F><N><Q><H><I><L><L><T><D><H><I><H><T><A><E><K><P><S><E><C><G><K><A><F><S><H><T><S><S><L><S><Q><P><Q><M><L><L><T><G><E><K><P><Y><K><C><D><E><C><G><K><R><F><S><Q><R><I><H><L><I><Q><H><Q><R><I><H><T><G><E><K><P><F><I><C><N><G><C><G><K><A><F><R><Q><H><S><S><F><T><Q><H><L><R><I><H><T><G><E><K><P><Y><K><C><N><Q><C><G><K><A><F><S><R><I><T><S><L><T><E><H><H><R><L><H><T><G><E><K><P><Y><E><C><G><F><C><G><K><A><F><S><Q><R><T><H><L><N><Q><H><E><R><T><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><S><Q><S><A><H><L><N><Q><H><R><K><I><H><T><R><E><K><L><C><E><Y><K><C><E><Q><T><V><R><H><S><P><S><F><S><S><T>
May be involved in transcriptional regulation.<BOP>
Q8N859
P42773
CDN2C_HUMAN
p18-INK6
Homo
<M><A><E><P><W><G><N><E><L><A><S><A><A><A><R><G><D><L><E><Q><L><T><S><L><L><Q><N><N><V><N><V><N><A><Q><N><G><F><G><R><T><A><L><Q><V><M><K><L><G><N><P><E><I><A><R><R><L><L><L><R><G><A><N><P><D><L><K><D><R><T><G><F><A><V><I><H><D><A><A><R><A><G><F><L><D><T><L><Q><T><L><L><E><F><Q><A><D><V><N><I><E><D><N><E><G><N><L><P><L><H><L><A><A><K><E><G><H><L><R><V><V><E><F><L><V><K><H><T><A><S><N><V><G><H><R><N><H><K><G><D><T><A><C><D><L><A><R><L><Y><G><R><N><E><V><V><S><L><M><Q><A><N><G><A><G><G><A><T><N><L><Q>
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.<BOP>
P42773
Q5TEU4
NDUF5_HUMAN
Putative methyltransferase NDUFAF5
Homo
<M><L><R><P><A><G><L><W><R><L><C><R><R><P><W><A><A><R><V><P><A><E><N><L><G><R><R><E><V><T><S><G><V><S><P><R><G><S><T><S><P><R><T><L><N><I><F><D><R><D><L><K><R><K><Q><K><N><W><A><A><R><Q><P><E><P><T><K><F><D><Y><L><K><E><E><V><G><S><R><I><A><D><R><V><Y><D><I><P><R><N><F><P><L><A><L><D><L><G><C><G><R><G><Y><I><A><Q><Y><L><N><K><E><T><I><G><K><F><F><Q><A><D><I><A><E><N><A><L><K><N><S><S><E><T><E><I><P><T><V><S><V><L><A><D><E><E><F><L><P><F><K><E><N><T><F><D><L><V><V><S><S><L><S><L><H><W><V><N><D><L><P><R><A><L><E><Q><I><H><Y><I><L><K><P><D><G><V><F><I><G><A><M><F><G><G><D><T><L><Y><E><L><R><C><S><L><Q><L><A><E><T><E><R><E><G><G><F><S><P><H><I><S><P><F><T><A><V><N><D><L><G><H><L><L><G><R><A><G><F><N><T><L><T><V><D><T><D><E><I><Q><V><N><Y><P><G><M><F><E><L><M><E><D><L><Q><G><M><G><E><S><N><C><A><W><N><R><K><A><L><L><H><R><D><T><M><L><A><A><A><A><V><Y><R><E><M><Y><R><N><E><D><G><S><V><P><A><T><Y><Q><I><Y><Y><M><I><G><W><K><Y><H><E><S><Q><A><R><P><A><E><R><G><S><A><T><V><S><F><G><E><L><G><K><I><N><N><L><M><P><P><G><K><K><S><Q>
Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages . Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 . May also have methyltransferase activity (Probable).<BOP>
Q5TEU4
O00204
ST2B1_HUMAN
Sulfotransferase family cytosolic 2B member 1
Homo
<M><D><G><P><A><E><P><Q><I><P><G><L><W><D><T><Y><E><D><D><I><S><E><I><S><Q><K><L><P><G><E><Y><F><R><Y><K><G><V><P><F><P><V><G><L><Y><S><L><E><S><I><S><L><A><E><N><T><Q><D><V><R><D><D><D><I><F><I><I><T><Y><P><K><S><G><T><T><W><M><I><E><I><I><C><L><I><L><K><E><G><D><P><S><W><I><R><S><V><P><I><W><E><R><A><P><W><C><E><T><I><V><G><A><F><S><L><P><D><Q><Y><S><P><R><L><M><S><S><H><L><P><I><Q><I><F><T><K><A><F><F><S><S><K><A><K><V><I><Y><M><G><R><N><P><R><D><V><V><V><S><L><Y><H><Y><S><K><I><A><G><Q><L><K><D><P><G><T><P><D><Q><F><L><R><D><F><L><K><G><E><V><Q><F><G><S><W><F><D><H><I><K><G><W><L><R><M><K><G><K><D><N><F><L><F><I><T><Y><E><E><L><Q><Q><D><L><Q><G><S><V><E><R><I><C><G><F><L><G><R><P><L><G><K><E><A><L><G><S><V><V><A><H><S><T><F><S><A><M><K><A><N><T><M><S><N><Y><T><L><L><P><P><S><L><L><D><H><R><R><G><A><F><L><R><K><G><V><C><G><D><W><K><N><H><F><T><V><A><Q><S><E><A><F><D><R><A><Y><R><K><Q><M><R><G><M><P><T><F><P><W><D><E><D><P><E><E><D><G><S><P><D><P><E><P><S><P><E><P><E><P><K><P><S><L><E><P><N><T><S><L><E><R><E><P><R><P><N><S><S><P><S><P><S><P><G><Q><A><S><E><T><P><H><P><R><P><S>
Sulfonates pregnenolone but not cholesterol.<BOP>
O00204
Q9H6E4
CC134_HUMAN
Coiled-coil domain-containing protein 134
Homo
<M><D><L><L><Q><F><L><A><F><L><F><V><L><L><L><S><G><M><G><A><T><G><T><L><R><T><S><L><D><P><S><L><E><I><Y><K><K><M><F><E><V><K><R><R><E><Q><L><L><A><L><K><N><L><A><Q><L><N><D><I><H><Q><Q><Y><K><I><L><D><V><M><L><K><G><L><F><K><V><L><E><D><S><R><T><V><L><T><A><A><D><V><L><P><D><G><P><F><P><Q><D><E><K><L><K><D><A><F><S><H><V><V><E><N><T><A><F><F><G><D><V><V><L><R><F><P><R><I><V><H><Y><Y><F><D><H><N><S><N><W><N><L><L><I><R><W><G><I><S><F><C><N><Q><T><G><V><F><N><Q><G><P><H><S><P><I><L><S><L><M><A><Q><E><L><G><I><S><E><K><D><S><N><F><Q><N><P><F><K><I><D><R><T><E><F><I><P><S><T><D><P><F><Q><K><A><L><R><E><E><E><K><R><R><K><K><E><E><K><R><K><E><I><R><K><G><P><R><I><S><R><S><Q><S><E><L>
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.<BOP>
Q9H6E4
P49918
CDN1C_HUMAN
p57Kip2
Homo
<M><S><D><A><S><L><R><S><T><S><T><M><E><R><L><V><A><R><G><T><F><P><V><L><V><R><T><S><A><C><R><S><L><F><G><P><V><D><H><E><E><L><S><R><E><L><Q><A><R><L><A><E><L><N><A><E><D><Q><N><R><W><D><Y><D><F><Q><Q><D><M><P><L><R><G><P><G><R><L><Q><W><T><E><V><D><S><D><S><V><P><A><F><Y><R><E><T><V><Q><V><G><R><C><R><L><L><L><A><P><R><P><V><A><V><A><V><A><V><S><P><P><L><E><P><A><A><E><S><L><D><G><L><E><E><A><P><E><Q><L><P><S><V><P><V><P><A><P><A><S><T><P><P><P><V><P><V><L><A><P><A><P><A><P><A><P><A><P><V><A><A><P><V><A><A><P><V><A><V><A><V><L><A><P><A><P><A><P><A><P><A><P><A><P><A><P><A><P><V><A><A><P><A><P><A><P><A><P><A><P><A><P><A><P><A><P><A><P><A><P><D><A><A><P><Q><E><S><A><E><Q><G><A><N><Q><G><Q><R><G><Q><E><P><L><A><D><Q><L><H><S><G><I><S><G><R><P><A><A><G><T><A><A><A><S><A><N><G><A><A><I><K><K><L><S><G><P><L><I><S><D><F><F><A><K><R><K><R><S><A><P><E><K><S><S><G><D><V><P><A><P><C><P><S><P><S><A><A><P><G><V><G><S><V><E><Q><T><P><R><K><R><L><R>
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.<BOP>
P49918
Q8N988
ZN557_HUMAN
Zinc finger protein 557
Homo
<M><A><A><V><V><L><P><P><T><A><A><S><Q><R><E><G><H><T><E><G><G><E><L><V><N><E><L><L><K><S><W><L><K><G><L><V><T><F><E><D><V><A><V><E><F><T><Q><E><E><W><A><L><L><D><P><A><Q><R><T><L><Y><R><D><V><M><L><E><N><C><R><N><L><A><S><L><G><N><Q><V><D><K><P><R><L><I><S><Q><L><E><Q><E><D><K><V><M><T><E><E><R><G><I><L><S><G><T><C><P><D><V><E><N><P><F><K><A><K><G><L><T><P><K><L><H><V><F><R><K><E><Q><S><R><N><M><K><M><E><R><N><H><L><G><A><T><L><N><E><C><N><Q><C><F><K><V><F><S><T><K><S><S><L><T><R><H><R><K><I><H><T><G><E><R><P><Y><G><C><S><E><C><G><K><S><Y><S><S><R><S><Y><L><A><V><H><K><R><I><H><N><G><E><K><P><Y><E><C><N><D><C><G><K><T><F><S><S><R><S><Y><L><T><V><H><K><R><I><H><N><G><E><K><P><Y><E><C><S><D><C><G><K><T><F><S><N><S><S><Y><L><R><P><H><L><R><I><H><T><G><E><K><P><Y><K><C><N><Q><C><F><R><E><F><R><T><Q><S><I><F><T><R><H><K><R><V><H><T><G><E><G><H><Y><V><C><N><Q><C><G><K><A><F><G><T><R><S><S><L><S><S><H><Y><S><I><H><T><G><E><Y><P><Y><E><C><H><D><C><G><R><T><F><R><R><R><S><N><L><T><Q><H><I><R><T><H><T><G><E><K><P><Y><T><C><N><E><C><G><K><S><F><T><N><S><F><S><L><T><I><H><R><R><I><H><N><G><E><K><S><Y><E><C><S><D><C><G><K><S><F><N><V><L><S><S><V><K><K><H><M><R><T><H><T><G><K><K><P><Y><E><C><N><Y><C><G><K><S><F><T><S><N><S><Y><L><S><V><H><T><R><M><H><N><R><Q><M>
May be involved in transcriptional regulation.<BOP>
Q8N988
O43808
PM34_HUMAN
Solute carrier family 25 member 17
Homo
<M><A><S><V><L><S><Y><E><S><L><V><H><A><V><A><G><A><V><G><S><V><T><A><M><T><V><F><F><P><L><D><T><A><R><L><R><L><Q><V><D><E><K><R><K><S><K><T><T><H><M><V><L><L><E><I><I><K><E><E><G><L><L><A><P><Y><R><G><W><F><P><V><I><S><S><L><C><C><S><N><F><V><Y><F><Y><T><F><N><S><L><K><A><L><W><V><K><G><Q><H><S><T><T><G><K><D><L><V><V><G><F><V><A><G><V><V><N><V><L><L><T><T><P><L><W><V><V><N><T><R><L><K><L><Q><G><A><K><F><R><N><E><D><I><V><P><T><N><Y><K><G><I><I><D><A><F><H><Q><I><I><R><D><E><G><I><S><A><L><W><N><G><T><F><P><S><L><L><L><V><F><N><P><A><I><Q><F><M><F><Y><E><G><L><K><R><Q><L><L><K><K><R><M><K><L><S><S><L><D><V><F><I><I><G><A><V><A><K><A><I><A><T><T><V><T><Y><P><L><Q><T><V><Q><S><I><L><R><F><G><R><H><R><L><N><P><E><N><R><T><L><G><S><L><R><N><I><L><Y><L><L><H><Q><R><V><R><R><F><G><I><M><G><L><Y><K><G><L><E><A><K><L><L><Q><T><V><L><T><A><A><L><M><F><L><V><Y><E><K><L><T><A><A><T><F><T><V><M><G><L><K><R><A><H><Q><H>
Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro.<BOP>
O43808
Q6X4W1
NSMF_HUMAN
Nasal embryonic luteinizing hormone-releasing hormone factor
Homo
<M><G><A><A><A><S><R><R><R><A><L><R><S><E><A><M><S><S><V><A><A><K><V><R><A><A><R><A><F><G><E><Y><L><S><Q><S><H><P><E><N><R><N><G><A><D><H><L><L><A><D><A><Y><S><G><H><D><G><S><P><E><M><Q><P><A><P><Q><N><K><R><R><L><S><L><V><S><N><G><C><Y><E><G><S><L><S><E><E><P><S><I><R><K><P><A><G><E><G><P><Q><P><R><V><Y><T><I><S><G><E><P><A><L><L><P><S><P><E><A><E><A><I><E><L><A><V><V><K><G><R><R><Q><R><H><P><H><H><H><S><Q><P><L><R><A><S><P><G><G><S><R><E><D><V><S><R><P><C><Q><S><W><A><G><S><R><Q><G><S><K><E><C><P><G><C><A><Q><L><A><P><G><P><T><P><R><A><F><G><L><D><Q><P><P><L><P><E><T><S><G><R><R><K><K><L><E><R><M><Y><S><V><D><R><V><S><D><D><I><P><I><R><T><W><F><P><K><E><N><L><F><S><F><Q><T><A><T><T><T><M><Q><A><I><S><V><F><R><G><Y><A><E><R><K><R><R><K><R><E><N><D><S><A><S><V><I><Q><R><N><F><R><K><H><L><R><M><V><G><S><R><R><V><K><A><Q><T><F><A><E><R><R><E><R><S><F><S><R><S><W><S><D><P><T><P><M><K><A><D><T><S><H><D><S><R><D><S><S><D><L><Q><S><S><H><C><T><L><D><E><A><F><E><D><L><D><W><D><T><E><K><G><L><E><A><V><A><C><D><T><E><G><F><V><P><P><K><V><M><L><I><S><S><K><V><P><K><A><E><Y><I><P><T><I><I><R><R><D><D><P><S><I><I><P><I><L><Y><D><H><E><H><A><T><F><E><D><I><L><E><E><I><E><R><K><L><N><V><Y><H><K><G><A><K><I><W><K><M><L><I><F><C><Q><G><G><P><G><H><L><Y><L><L><K><N><K><V><A><T><F><A><K><V><E><K><E><E><D><M><I><H><F><W><K><R><L><S><R><L><M><S><K><V><N><P><E><P><N><V><I><H><I><M><G><C><Y><I><L><G><N><P><N><G><E><K><L><F><Q><N><L><R><T><L><M><T><P><Y><R><V><T><F><E><S><P><L><E><L><S><A><Q><G><K><Q><M><I><E><T><Y><F><D><F><R><L><Y><R><L><W><K><S><R><Q><H><S><K><L><L><D><F><D><D><V><L>
Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.<BOP>
Q6X4W1
P45844
ABCG1_HUMAN
White protein homolog
Homo
<M><A><C><L><M><A><A><F><S><V><G><T><A><M><N><A><S><S><Y><S><A><E><M><T><E><P><K><S><V><C><V><S><V><D><E><V><V><S><S><N><M><E><A><T><E><T><D><L><L><N><G><H><L><K><K><V><D><N><N><L><T><E><A><Q><R><F><S><S><L><P><R><R><A><A><V><N><I><E><F><R><D><L><S><Y><S><V><P><E><G><P><W><W><R><K><K><G><Y><K><T><L><L><K><G><I><S><G><K><F><N><S><G><E><L><V><A><I><M><G><P><S><G><A><G><K><S><T><L><M><N><I><L><A><G><Y><R><E><T><G><M><K><G><A><V><L><I><N><G><L><P><R><D><L><R><C><F><R><K><V><S><C><Y><I><M><Q><D><D><M><L><L><P><H><L><T><V><Q><E><A><M><M><V><S><A><H><L><K><L><Q><E><K><D><E><G><R><R><E><M><V><K><E><I><L><T><A><L><G><L><L><S><C><A><N><T><R><T><G><S><L><S><G><G><Q><R><K><R><L><A><I><A><L><E><L><V><N><N><P><P><V><M><F><F><D><E><P><T><S><G><L><D><S><A><S><C><F><Q><V><V><S><L><M><K><G><L><A><Q><G><G><R><S><I><I><C><T><I><H><Q><P><S><A><K><L><F><E><L><F><D><Q><L><Y><V><L><S><Q><G><Q><C><V><Y><R><G><K><V><C><N><L><V><P><Y><L><R><D><L><G><L><N><C><P><T><Y><H><N><P><A><D><F><V><M><E><V><A><S><G><E><Y><G><D><Q><N><S><R><L><V><R><A><V><R><E><G><M><C><D><S><D><H><K><R><D><L><G><G><D><A><E><V><N><P><F><L><W><H><R><P><S><E><E><V><K><Q><T><K><R><L><K><G><L><R><K><D><S><S><S><M><E><G><C><H><S><F><S><A><S><C><L><T><Q><F><C><I><L><F><K><R><T><F><L><S><I><M><R><D><S><V><L><T><H><L><R><I><T><S><H><I><G><I><G><L><L><I><G><L><L><Y><L><G><I><G><N><E><A><K><K><V><L><S><N><S><G><F><L><F><F><S><M><L><F><L><M><F><A><A><L><M><P><T><V><L><T><F><P><L><E><M><G><V><F><L><R><E><H><L><N><Y><W><Y><S><L><K><A><Y><Y><L><A><K><T><M><A><D><V><P><F><Q><I><M><F><P><V><A><Y><C><S><I><V><Y><W><M><T><S><Q><P><S><D><A><V><R><F><V><L><F><A><A><L><G><T><M><T><S><L><V><A><Q><S><L><G><L><L><I><G><A><A><S><T><S><L><Q><V><A><T><F><V><G><P><V><T><A><I><P><V><L><L><F><S><G><F><F><V><S><F><D><T><I><P><T><Y><L><Q><W><M><S><Y><I><S><Y><V><R><Y><G><F><E><G><V><I><L><S><I><Y><G><L><D><R><E><D><L><H><C><D><I><D><E><T><C><H><F><Q><K><S><E><A><I><L><R><E><L><D><V><E><N><A><K><L><Y><L><D><F><I><V><L><G><I><F><F><I><S><L><R><L><I><A><Y><F><V><L><R><Y><K><I><R><A><E><R>
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP . The lipid efflux is ALB-dependent . Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol .<BOP>
P45844
Q9NVU7
SDA1_HUMAN
SDA1 domain-containing protein 1
Homo
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Required for 60S pre-ribosomal subunits export to the cytoplasm.<BOP>
Q9NVU7