id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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21646672 | Do hospital specific factors affect quality of blood pressure treatment in chronic kidney disease? | [
"Blood pressure (BP) is the most important modifiable risk factor for cardiovascular (CV) disease and progression of kidney dysfunction in patients with chronic kidney disease. Despite extensive antihypertensive treatment possibilities, adequate control is notoriously hard to achieve. Several determinants have been... | Despite extensive adjustments, a clinically relevant, statistically significant difference between hospitals was found in standardised BP measurements at baseline of a randomised controlled study. We hypothesise that differences in the approach towards BP control exist at the physician level and that these explain the ... | yes |
17192342 | Is skin autofluorescence a strong predictor of cardiac mortality in diabetes? | [
"Advanced glycation end products (AGEs) are biomarkers of metabolic stress and are thought to contribute to the increase of coronary heart disease (CHD) in diabetes. Tissue autofluorescence is related to the accumulation of AGEs. The aim of the present study was to evaluate the relationship between skin autofluores... | Skin autofluorescence is strongly related to cumulative metabolic burden. Skin autofluorescence seems strongly associated with cardiac mortality and may provide important clinical information for risk assessment. | yes |
26410436 | Is hyperglycemia associated with poor outcome in newborn infants undergoing therapeutic hypothermia for hypoxic ischemic encephalopathy? | [
"Therapeutic hypothermia (TH) improves survival and neurodevelopmental outcome in neonatal hypoxic ischemic encephalopathy (HIE). Both, hypoglycemia and hyperglycemia are common in infants with HIE. The relationship between hypoglycemia and hyperglycemia, and immediate outcome has not been well described.",
"A re... | Hyperglycemia on the first day portends poor outcome in newborn infants undergoing TH for HIE. | yes |
16087820 | Is discomfort in nursing home patients with severe dementia in whom artificial nutrition and hydration forgone? | [
"While there is debate about whether it may be better to forgo than to initiate artificial nutrition and hydration (ANH) in nursing home patients with severe dementia, the consequences of forgoing ANH in these patients, in particular their discomfort, have not yet been investigated.",
"In this prospective, longit... | Forgoing ANH in patients with severe dementia who scarcely or no longer eat or drink seems, in general, not to be associated with high levels of discomfort. The individual differences emphasize the need for constant attention for possible discomfort. | yes |
26898435 | Does vascular endothelial growth factor receptor-1 ( VEGFR-1 ) signaling enhance angiogenesis in a surgical sponge model? | [
"Vascular endothelial growth factor (VEGF)-A binds to both VEGF receptor (VEGFR)-1 and VEGFR-2, thereby promoting angiogenesis. It is widely accepted that VEGF-A, especially VEGFR-2, is a central player in angiogenesis, however the role of VEGFR-1 in angiogenesis remains unclear. The present study was conducted to ... | These results suggest that the VEGFR-1 tyrosine kinase signaling has an effect on angiogenesis. A selective VEGFR-1 agonist/antagonist could be a candidate therapeutic agent to control angiogenesis with recruitment of BM cells. | yes |
14636202 | Are vascular endothelial growth factor levels increased and associated with disease activity in patients with Behçet 's syndrome? | [
"Vascular endothelial growth factor (VEGF) is a cytokine participating in inflammation with potent endothelial cell effects. It is produced by macrophages, neutrophils and vascular endothelial cells and can alter vessel permeability. Behçet's syndrome is a systemic inflammatory disorder with unknown etiology. Vascu... | VEGF may participate in the course of Behçet's syndrome, especially in the active stage, and elevated levels of VEGF may be an additional risk factor for the development of ocular disease, contributing to poor visual outcome. | yes |
15747511 | Is [ Thoracic epidural analgesia effective in perioperative pain relief for uterine artery embolization ]? | [
"Uterine artery embolization (UAE) has become widely employed in Japan. Although several methods of anesthesia and analgesia are performed for UAE, pain control does not appear to be satisfactory. We report a series of UAE, successfully managed using thoracic epidural analgesia.",
"Before UAE an epidural analgesi... | Several phases of severe pain are seen perioperatively in UAE. Because thoracic epidural analgesia is easily administered and the dosage of the drugs used effectively controlled, it is a practical method for perioperative pain control for UAE. | yes |
17297638 | Does exposure to intermittent nociceptive stimulation under pentobarbital anesthesia disrupt spinal cord function in rats? | [
"Spinal cord plasticity can be assessed in spinal rats using an instrumental learning paradigm in which subjects learn an instrumental response, hindlimb flexion, to minimize shock exposure. Prior exposure to uncontrollable intermittent stimulation blocks learning in spinal rats but has no effect if given before sp... | The results suggest a surgical dose of pentobarbital (50 mg/kg) suppresses supraspinal (experiment 2) but not spinal (experiment 1) systems that modulate nociceptive input to the spinal cord by blocking the antinociception that is induced by this input (experiment 3). | yes |
22911870 | Does periostin facilitate skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma? | [
"Periostin, a novel matricellular protein, is recently reported to play a crucial role in tissue remodeling and is highly expressed under fibrotic conditions. This study was undertaken to assess the role of periostin in scleroderma.",
"Using skin from patients and healthy donors, the expression of periostin was a... | Periostin plays an essential role in the pathogenesis of Bleomycin-induced scleroderma in mice. Periostin may represent a potential therapeutic target for human scleroderma. | yes |
23372434 | Is increased co-expression of macrophage migration inhibitory factor and matrix metalloproteinase 9 associated with tumor recurrence of meningioma? | [
"We detected the expression of MIF and matrix metalloproteinase 9 (MMP9) in meningiomas to determine whether they are valuable recurrence predictor for meningioma.",
"67 cases of meningiomas, including 57 benign tumors (WHO grade I) and 10 non-benign tumors (WHO grade II and III), were collected, and expression o... | Together with histological grade, increased co-expression of MIF and MMP9 in tumor might be a valuable predictor for recurrence, especially for benign meningiomas. | yes |
23943815 | Is onyx associated with poor venous penetration in the treatment of spinal dural arteriovenous fistulas? | [
"The use of Onyx has become the mainstream for the treatment of cranial dural arteriovenous fistulas (AVFs) and arteriovenous malformations, but the reported success for type I spinal dural arteriovenous fistulas (sDAVFs) remains limited. We review our experience with Onyx and report its limitations in the treatmen... | Our experience with Onyx for type I sDAVF embolization has been tempered by difficulty in achieving venous penetration and, consequently, a high rate of recurrence. For management of these fistulas, we favor NBCA or surgical treatment. | yes |
22267015 | Is plasma HIV-RNA the key determinant of long-term antibody persistence after Yellow fever immunization in a cohort of 364 HIV-infected patients? | [
"In HIV-infected patients, data on immunogenicity of Yellow fever immunization are scarce, and there is conflicting evidence of the influence of CD4 T-cell count and plasma HIV RNA on neutralizing antibody titer (NT) after vaccine injection.",
"In this prospective cohort study, NT was measured in all consecutive ... | The key determinant of antibody response was the HIV replication status at immunization. No association was found between antibody response and CD4 T-cell count. | yes |
19596951 | Does decrease of E-cadherin expression in canine cutaneous histiocytoma appear to be related to its spontaneous regression? | [
"Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression.",
"E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, ... | This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression. The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression. | yes |
26546790 | Are anticipatory and consummatory effects of ( hedonic ) chocolate intake associated with increased circulating levels of the orexigenic peptide ghrelin and endocannabinoids in obese adults? | [
"Hedonic hunger refers to consumption of food just for pleasure and not to maintain energy homeostasis. Recently, consumption of food for pleasure was reported to be associated with increased circulating levels of both the orexigenic peptide ghrelin and the endocannabinoid 2-arachidonoyl-glycerol (2-AG) in normal-w... | When motivation to eat is generated by exposure to, and consumption of, chocolate a peripheral activation of specific endogenous rewarding chemical signals, including ghrelin, AEA, and 2-AG, is observed in obese subjects. Although preliminary, these findings predict the effectiveness of ghrelin and endocannabinoid anta... | yes |
19439087 | Does impact of duplicate gene copies on phylogenetic analysis and divergence time estimate in butterflies? | [
"The increase in availability of genomic sequences for a wide range of organisms has revealed gene duplication to be a relatively common event. Encounters with duplicate gene copies have consequently become almost inevitable in the context of collecting gene sequences for inferring species trees. Here we examine th... | These results are consistent with diversification of the butterfly families following the radiation of angiosperms and suggest that some classes of opsin genes may be usefully employed for both phylogenetic reconstruction and divergence time estimation. | yes |
19471105 | Does sTAT3 mediate protection from liver inflammation after partial hepatectomy? | [
"The liver has the unique capacity to restore its mass by hepatocyte proliferation after injury or transplantation. The present study investigated whether the regenerating liver responds to immune stimuli in the same way as the quiescent one.",
"We performed partial hepatectomy (PHx) in mice, then stimulated the ... | The regenerating liver is resistant to ConA induced immune assaulting, and STAT3 is the major player in the protection process. | yes |
23536187 | Is the auxiliary subunit KChIP2 an essential regulator of homeostatic excitability? | [
"The necessity for, or redundancy of, distinctive KChIP proteins is not known.",
"Deletion of KChIP2 leads to increased susceptibility to epilepsy and to a reduction in IA and increased excitability in pyramidal hippocampal neurons."
] | KChIP2 is essential for homeostasis in hippocampal neurons. | yes |
20398153 | Does trail Making Test predict physical impairment and mortality in older persons? | [
"To examine whether performance in the Trail Making Test (TMT) predicts mobility impairment and mortality in older persons.",
"Prospective cohort study.",
"Community-dwelling older persons enrolled in the Invecchiare in Chianti (InCHIANTI) Study.",
"Five hundred eighty-three participants aged 65 and older and... | Performance on the TMT is a strong, independent predictor of mobility impairment, accelerated decline in lower extremity function, and death in older adults living in the community. The TMT could be a useful addition to geriatric assessment. | yes |
27242527 | Does rifaximin improve Clostridium difficile Toxin A-Induced Toxicity in Caco-2 Cells by the PXR-Dependent TLR4/MyD88/NF-κB Pathway? | [
"Clostridium difficile infections (CDIs) caused by Clostridium difficile toxin A (TcdA) lead to severe ulceration, inflammation and bleeding of the colon, and are difficult to treat.",
"The study aimed to evaluate the effect of rifaximin on TcdA-induced apoptosis in intestinal epithelial cells and investigate the... | Rifaximin improved TcdA-induced toxicity in Caco-2 cells by the PXR-dependent TLR4/MyD88/NF-κB pathway mechanism, and may be useful in the treatment of CDIs. | yes |
21795022 | Do dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis? | [
"Animal studies have demonstrated that dietary supplementation with flaxseed oil inhibits colorectal cancer growth. Recent data indicate that walnuts have strong antiproliferative properties against colon cancer cells in vitro but no previous study has assessed the effects of walnuts in vivo or performed a joint ev... | We conclude that walnuts in the diet inhibit colorectal cancer growth by suppressing angiogenesis. Further studies are needed to confirm our findings in humans and explore underlying mechanisms. | yes |
25093591 | Do brain neuroplastic changes accompany anxiety and memory deficits in a model of complex regional pain syndrome? | [
"Complex regional pain syndrome (CRPS) is a painful condition with approximately 50,000 annual new cases in the United States. It is a major cause of work-related disability, chronic pain after limb fractures, and persistent pain after extremity surgery. Additionally, CRPS patients often experience cognitive change... | The study findings provide novel observations regarding behavioral changes and brain plasticity in a mouse model of CRPS. In addition to elucidating some of the supraspinal correlates of the syndrome, this work supports the potential use of therapeutic interventions that not only directly target sensory input and other... | yes |
15462116 | Is thyroid hormone transport disturbed in erythrocytes from patients with chronic renal failure on hemodialysis? | [
"To now, there are no studies reporting whether thyroid hormones (THs) transport play a role in thyroid hormone dysfunction observed in chronic renal failure (CRF). Therefore, the aim of this study was to investigate the transport of THs in erythrocytes from patients with CRF on hemodialysis (HD).",
"[125I]-L-tri... | Despite the fact that uremic patients on hemodialysis show low serum levels of LT3, changes in LT3 influx and efflux could act as a compensatory mechanism that neutralize thyroid hormone dysfunction in order to maintain the euthyroid state. | yes |
18462368 | Is cOX-2 expression in sporadic colorectal adenomatous polyps linked to adenoma characteristics? | [
"To assess cyclooxygenase-2 (COX-2) expression in sporadic colonic adenomas and to explore the association of COX-2 positivity with adenoma characteristics linked to increased risk of malignant transformation.",
"COX-2 expression and localization were assessed in 64 colorectal adenomas and 35 paired adjacent norm... | This study associates COX-2 epithelial expression with a number of adenoma characteristics that convey an increased risk of malignant transformation. This is in keeping with a positive role for COX-2 in early colorectal carcinogenesis. | yes |
23312851 | Are deep cerebral microbleeds negatively associated with HDL-C in elderly first-time ischemic stroke patients? | [
"Cerebral microbleeds (CMBs) detected on T2*-weighted MRI gradient-echo have been associated with increased risk of cerebral infarction. We evaluated risk factors for these lesions in a cohort of first-time ischemic stroke patients.",
"Presence of CMBs in consecutive first-time ischemic stroke patients was evalua... | Low HDL-C may be a risk factor of deep CMBs, including advanced PVH status, in elderly patients with acute ischemic stroke. Management of HDL-C levels might be a therapeutic target for the prevention of recurrence of stroke. | yes |
21464990 | Is the induction of microRNA targeting IRS-1 involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes? | [
"Mitochondrial dysfunction induces insulin resistance in myocytes via a reduction of insulin receptor substrate-1 (IRS-1) expression. However, the effect of mitochondrial dysfunction on insulin sensitivity is not understood well in hepatocytes. Although research has implicated the translational repression of target... | We demonstrated that miR-126 was actively involved in the development of insulin resistance induced by mitochondrial dysfunction. These data provide novel insights into the molecular basis of insulin resistance, and implicate miRNA in the development of metabolic disease. | yes |
23266647 | Is abnormal glycogen in astrocytes sufficient to cause adult polyglucosan body disease? | [
"A 45-year old woman of Cambodian ethnic background presented with fatal respiratory failure due to a severe diaphragmatic dysfunction. Two years before, she had developed early onset of urinary symptoms.",
"Neuroimaging showed atrophy of the spine and medulla as well as a leukodystrophy affecting both supra- and... | Storage of abnormal glycogen in astrocytes is sufficient to cause the leukodystrophy of APBD. Since brain glycogen is almost exclusively metabolized in astrocytes, this observation sheds light on the pathophysiology of APBD. In addition, this is the first report of an APBD patient presenting with a subacute diaphragmat... | yes |
15138119 | Does gamma-hydroxybutyrate protect the liver from warm ischemia-reperfusion injury in rat? | [
"Ischemia-reperfusion (I/R) syndrome remains an important clinical consideration in hepatic surgery, hemorrhagic shock, and liver transplantation. gamma-hydroxybutyrate (GHB) has been reported to exert protective effects against ischemia-reperfusion injury to various organs. To investigate whether GHB protects the ... | GHB may significantly protect the liver from hepatic warm ischemia-reperfusion injury via several different mechanisms. | yes |
21902454 | Does comparative genomics of thiol oxidoreductases reveal widespread and essential functions of thiol-based redox control of cellular processes? | [
"Redox regulation of cellular processes is an important mechanism that operates in organisms from bacteria to mammals. Much of the redox control is provided by thiol oxidoreductases: proteins that employ cysteine residues for redox catalysis. We wanted to identify thiol oxidoreductases on a genome-wide scale and us... | These data provide information about organization and properties of thiol-based redox control, whose use is increased with the increase in complexity of organisms. Our data also show an essential combined function of a set of thiol oxidoreductases, and of thiol-based redox regulation in general, in all living organisms... | yes |
10851216 | Do hemodynamic stresses induce endothelial dysfunction and remodeling of pulmonary artery in experimental compensated heart failure? | [
"We hypothesized that, in compensated heart failure (HF), hemodynamic perturbations and their consequences exist in pulmonary artery (PA) despite the absence of any perturbation in thoracic aorta (TA).",
"The left coronary artery was ligated in 20 male Wistar rats with compensated HF. Four months after ligation, ... | In compensated HF induced by small myocardial infarction, hemodynamics, vascular wall function, and structure are altered in PA but preserved in TA. These results indicate that the pulmonary vascular bed is an early target of regional circulatory alterations in HF. | yes |
25226558 | Does intra-artery infusion of recombinant human erythropoietin reduce blood-brain barrier disruption in rats following cerebral ischemia and reperfusion? | [
"Intra-artery infusion of recombinant human erythropoietin (rhEPO) has recently been reported to confer neuroprotection against cerebral ischemia-reperfusion injury in animal models; however, the molecular mechanisms are still under investigation. The present study focused on the specific mechanism involved in bloo... | Treatment with rhEPO through MCA infusion prevented brain edema formation and infarction through inhibition of MMP-mediated BBB disruption in acute ischemic stroke. | yes |
23050675 | Does myostatin inhibit proliferation of human urethral rhabdosphincter satellite cells? | [
"Myostatin, a member of the transforming growth factor-β superfamily, is a negative regulator of myogenesis in skeletal muscle. We examined the effect of myostatin and myostatin inhibition by an antagonistic agent, follistatin, on growth of human urethral rhabdosphincter satellite cells (muscle stem cells) to devel... | Inhibition of myostatin function might be a useful pathway in the development of novel strategies for stimulating rhabdosphincter cells regeneration to treat stress urinary incontinence. | yes |
15942460 | Does supplementation with tetrahydrobiopterin prevent the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress? | [
"The pteridine cofactor tetrahydrobiopterin (BH4) has emerged as a critical determinant of endothelial nitric oxide synthase (eNOS) activity. When BH4 availability is limited, eNOS does not produce nitric oxide (NO) but instead generates superoxide. BH4 may reverse endothelial dysfunction due to cardiovascular dise... | These results indicate that BH4 might prevent the development of hypertension and myocardial hypertrophy, as well as the Ang II-induced production of superoxide and NO, thereby reducing the production of peroxynitrite. Therefore, BH4 may protect against the cardiovascular manifestations of oxidative and nitrosative str... | yes |
18237379 | Do extracorporeal shock waves down-regulate the expression of interleukin-10 and tumor necrosis factor-alpha in osteoarthritic chondrocytes? | [
"The purpose of this study was to investigate the effects of extra corporeal shock waves (ESW) therapy on the metabolism of healthy and osteoarthritic human chondrocytes, and particularly on the expression of IL-10, TNF-alpha and beta1 integrin.",
"Human adult articular cartilage was obtained from 9 patients (6 m... | Our study confirmed that osteoarthritic chondrocytes express low beta1 integrin and high TNF-alpha and IL-10 levels. Nonetheless, ESW treatment application down-regulate the intracellular levels of TNF-alpha and IL-10 by chondrocytes, suggesting that ESW might restore TNF-alpha and IL-10 production by osteoarthritic ch... | yes |
18703241 | Does `` Prehabilitation '' prior to CABG surgery improve physical functioning and depression? | [
"Many patients demonstrate psychological distress and reduced physical activity before coronary artery bypass graft surgery (CABG). Here we evaluated the addition of a brief, cognitive-behavioural intervention (the HeartOp Programme) to routine nurse counselling for people waiting for CABG surgery.",
"Randomised ... | Nurse counselling with the HeartOp Programme reduces depression and cardiac misconceptions and improves physical functioning before bypass surgery significantly more than nurse counselling alone and meets the accepted criteria for cost efficacy. | yes |
25288678 | Is expression of homologous RND efflux pump genes dependent upon AcrB expression : implications for efflux and virulence inhibitor design? | [
"Enterobacteriaceae have multiple efflux pumps that confer intrinsic resistance to antibiotics. AcrB mediates clinically relevant multidrug resistance and is required for virulence and biofilm formation, making it an attractive target for the design of inhibitors. The aim of this study was to assess the viability o... | These data indicate that it is critical to understand which pumps an inhibitor is active against and the effect of this on the expression of homologous systems. For some antimicrobials, an inhibitor with activity against multiple pumps will have a greater impact on susceptibility, but an unintended consequence of this ... | yes |
26925135 | Does aminoguanidine cream ameliorate skin tissue microenvironment in diabetic rats? | [
"The aim of the study was to explore the effect of aminoguanidine cream on the skin tissue microenvironment in diabetic rats.",
"A total of 51 healthy male Sprague Dawley (SD) rats were randomly divided into three groups: the diabetes group (n = 18), the aminoguanidine group (n = 18) and the control group (n = 15... | Aminoguanidine may have a good systemic effect on alleviating the pathological changes of skin tissue in diabetic rats, which may be attributed to the regulation of GSH-PX, TNF-α, IL-8, ICAM and IL-1α. | yes |
23713704 | Does exogenous normal lymph alleviate lipopolysaccharide-induced acute kidney injury in rats? | [
"Acute kidney injury (AKI) is a common pathological process which occurs in hemorrhage, intoxication, etc. It has been shown that the lymphatic circulation plays an important regulatory role in the pathogenesis of hemorrhage shock, and that exogenous normal lymph (ENL) has a beneficial effect on multiple organ inju... | The present results indicate that ENL protect against LPS-induced AKI, suggesting an alternative therapeutic strategy for treatment of kidney injury accompanied with severe infection or sepsis. | yes |
20387248 | Do [ Cardiac mast cells accumulation and degranulation contribute to collagen deposition after coronary microembolization ]? | [
"To investigate potential pathophysiological role of cardiac mast cells accumulation and degranulation on the collagen deposition after coronary microembolization (CME).",
"CME was induced in miniswine by selective infusion of 15X10(4) microspheres (diameter, 45 mum) into the left anterior descending artery group... | MCs accumulation and degranulating contribute to myocardial fibrosis collagen deposition. | yes |
24406477 | Does new approach to the treatments of short bowel syndrome-associated intestinal failure? | [
"Teduglutide, a recombinant analog of human glucagon-like peptide 2, has recently been approved in the US and Europe (Gattex and Revestive, respectively) as the first targeted treatment of short bowel syndrome-associated intestinal failure (SBS-IF). Glucagon-like peptide 2 improves structural and functional intesti... | Teduglutide will add incremental benefit to the limited medical treatment armamentarium in SBS patients by maximizing intestinal absorption, decreasing fecal losses, thereby decreasing or even eliminating the need for parenteral support. Future research should target and implement other key hormones with similar and po... | yes |
9579483 | Do hypoxia and vascular endothelial growth factor stimulate angiogenic integrin expression in bovine retinal microvascular endothelial cells? | [
"Integrins alphavbeta3 and alphavbeta5 are cell-to-matrix adhesion molecules that have been reported to mediate vascular cell proliferation and migration. The authors investigated the regulation of expression of these angiogenic integrins by hypoxia and vascular endothelial growth factor (VEGF) in retinal microvasc... | These data suggest that hypoxia stimulates expression of vascular integrins alphavbeta3 and alphavbeta5 in retinal microvascular endothelial cells partially through autocrine-paracrine action of VEGF induced by the hypoxic state. | yes |
21740551 | Is statin pre-treatment associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke? | [
"Statins reportedly have anti-inflammatory and anti-thrombotic effects aside from cholesterol-lowering. This study aimed to evaluate the effect of pre-existing statin use on platelet activation markers and clinical outcome in acute ischemic stroke patients.",
"This prospective study evaluated 172 patients with ac... | Pre-existing statin use is associated with decreased platelet activity as well as improved clinical outcome and reduced END in patients with acute ischemic stroke. | yes |
11182340 | Is high-grade prostatic intraepithelial neoplasia with adjacent atypia associated with a higher incidence of cancer on subsequent needle biopsy than high-grade prostatic intraepithelial neoplasia alone? | [
"High-grade prostatic intraepithelial neoplasia (HGPIN) is often considered a premalignant lesion of the prostate. Its incidence ranges from 0.7% to 20% in all prostate biopsies, and patients with HGPIN on initial biopsy are reportedly found to have a higher risk of cancer on subsequent biopsy. The purpose of our s... | The incidence of HGPIN alone in our experience is 4.3% (21 of 485). Patients with HGPIN with adjacent atypical glands suspicious for cancer have a significantly higher incidence of cancer on subsequent biopsy than patients with HGPIN alone. | yes |
11282084 | Does hypoxia induce heat shock protein expression in human coronary artery bypass grafts? | [
"Heat shock proteins (HSPs) are molecular chaperones which are essential for cell survival. Heat shock and hypoxia markedly increase the expression of several HSPs in various tissues, i.e. heart. In our in vitro study, we investigated whether HSPs are inducible in human vessels which are used as coronary artery byp... | These findings demonstrate the common cellular defense mechanism of HSP expression in response to stress in coronary artery bypass grafts. Hypoxia and heat treatment strongly induce Hsp72 and Hsp73 expression in human coronary artery bypass grafts. | yes |
25884615 | Does simvastatin alleviate cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression? | [
"Statins decrease heart disease risk, but their mechanisms are not completely understood. We examined the role of the TGF-β receptor III (TGFBR3) in the inhibition of cardiac fibrosis by simvastatin.",
"Myocardial infarction (MI) was induced by ligation of the left anterior descending coronary artery in mice give... | TGFBR3 mediated the decreased cardiac fibrosis, collagen deposition and fibroblast activity, induced by simvastatin, following MI. These effects involved GIPC inhibition of the ERK1/2/JNK pathway. | yes |
25149194 | Are increased large VLDL and small LDL particles related to lower bilirubin in Type 2 diabetes mellitus? | [
"Bilirubin may protect against atherosclerotic cardiovascular disease by virtue of its anti-oxidative properties, but lower bilirubin may also be associated to atherogenic lipoprotein abnormalities. We determined associations of plasma (apo)lipoproteins and lipoprotein subfractions in subjects with and without type... | Increased triglycerides, as well as large VLDL and small LDL particles are associated negatively, whereas HDL cholesterol is associated positively with bilirubin in T2DM. The proposed pro-atherogenic effects of low bilirubin could in part be attributed to relationships with abnormalities in (apo)lipoproteins and lipopr... | yes |
16925671 | Does pancreas storage in oxygenated perfluorodecalin restore post-transplant function of isolated pig islets pre-damaged by warm ischemia? | [
"Cold storage in oxygenated perfluorodecalin (PFD) restores transplant function of ischemically damaged dog pancreata and reduces the impact of cold ischemia on recovery of isolated human islets. Whether PFD storage can improve islet isolation from pancreata exposed to significant warm ischemia (WI) is unclear yet.... | The present study suggests that pancreas short-term storage in oxygenated PFD improves in vitro but not the in vivo function of ischemically damaged pig islets. | no |
24926549 | Is b7-H1 expression in malignant pleural mesothelioma associated with sarcomatoid histology and poor prognosis? | [
"B7 homolog 1 (B7-H1; aka programmed cell death 1 ligand 1) is a negative costimulatory molecule that is associated with poor prognosis in many tumor types. Given the poor prognosis and the limited treatments available for mesothelioma, we decided to examine B7-H1 expression and its association with survival in pat... | B7-H1 is expressed in a substantial proportion of malignant pleural mesotheliomas and is associated with poor survival. Almost all malignant pleural mesotheliomas with sarcomatoid differentiation expressed B7-H1. The expression of B7-H1 may have important therapeutic implications for the management of malignant pleural... | yes |
8203696 | Does social influence on the sexual behavior of youth at risk for HIV exposure? | [
"Adolescents are increasingly at risk for infection with human immunodeficiency virus (HIV) and other sexually transmitted diseases, especially in poor urban minority communities. To aid the design of interventions in these communities, this study investigated the role of knowledge, attitudes, perceived parental mo... | The early onset and prevalence of sexual behavior and the importance of peer group influence call for early interventions that simultaneously influence the parents and peers in children's social networks. | yes |
19284624 | Do particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose? | [
"Airborne particles entering the respiratory tract may interact with the apical plasma membrane (APM) of epithelial cells and enter them. Differences in the entering mechanisms of fine (between 0.1 microm and 2.5 microm) and ultrafine ( <or= 0.1 microm) particles may be associated with different effects on the APM.... | This study demonstrates a particle-induced enlargement of the APM surface area of a pulmonary epithelial cell line, depending on particle surface area dose. Particle uptake by epithelial cells does not seem to be responsible for this effect. We propose that direct interactions between particle surface area and cell mem... | yes |
15019539 | Are lipoprotein concentrations in newborns associated with allelic variations in their mothers? | [
"Factors determining lipoprotein concentrations in the fetus are not yet fully understood. We postulated that an important factor is the genetic make-up of the mother. In the present study, we examined the associations between the cord blood concentrations of lipoproteins of 525 newborns and the polymorphisms prese... | This is the first evidence that maternal genetic variations influence fetal lipoprotein concentrations, independent of the genetic status of the fetus and of the variations of maternal lipoprotein concentrations generated by these genetic variants. It suggests that proteic components of maternal lipoproteins strongly c... | yes |
22279029 | Does early increase in blood glucose in patients resuscitated from out-of-hospital ventricular fibrillation predict poor outcome? | [
"To describe the trend of blood glucose immediately after successful resuscitation from out-of-hospital ventricular fibrillation.",
"Data from cardiac arrest registry supplemented with blood glucose data were analyzed in this population-based observational study. Between 2005 and 2009, a total of 170 adult patien... | Patients who are resuscitated from out-of-hospital ventricular fibrillation, but whose outcome is unfavorable are characterized by significant increase of blood glucose in the ultraacute postresuscitation phase. | yes |
12615677 | Does simvastatin reduce the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients? | [
"The intercellular adhesion molecule-1 (ICAM-1/CD54) and its ligand, CD11a/CD18, mediate endothelial adhesion of leukocytes and their consecutive transmigration. Anti-inflammatory effects of statins are considered to be exerted in part through inhibition of leukocyte-endothelial interactions. We investigated the in... | Statin-induced inhibition of expression of CD54 and CD18/CD11a in PBMCs and HUVECs with consecutive loss of adhesive function may contribute to the anti-inflammatory effects of these drugs and some of their beneficial clinical activities. | yes |
21082233 | Is long Y chromosome a fetal loss risk? | [
"To assess the long Y chromosome genetic effect on human pregnancy outcomes.",
"We studied all records of pregnancies by human sperm donors after artificial insemination or in vitro fertilization at the Reproductive and Genetic Hospital of Citic-Xiangya. Fetal losses were compared from two groups of sperm donors:... | A long Y chromosome may therefore be considered as a normal variant. | no |
24358257 | Does highly-sensitive allele-specific PCR testing identify a greater prevalence of transmitted HIV drug resistance in Japan? | [
"The transmission of drug-resistant HIV in newly identified infected populations has become an underlying epidemic which can be better assessed with sensitive resistance testing. Since minority drug resistant variants cannot be detected by bulk sequencing, methods with improved sensitivity are required. Thus, the g... | Using AS-PCR substantially increased the detection of transmitted drug resistance in this population from 15.4% to 26.8%, further supporting the benefit of sensitive testing among drug-naïve populations. Since the clinical impact of minority drug-resistant populations is not fully comprehended for all mutations, follow... | yes |
27030717 | Does crosstalk between astrocytic CXCL12 and microglial CXCR4 contribute to the development of neuropathic pain? | [
"Chemokine axis chemokine C-X-C motif ligand 12/C-X-C chemokine receptor type 4 (CXCL12/CXCR4) is an emerging pain modulator, but mechanisms for its involvement in neuropathic pain remain unclear. Here, we aimed to study whether CXCL12/CXCR4 axis modulated the development of neuropathic pain via glial mechanisms. I... | This study demonstrates the crosstalk between astrocytic CXCL12 and microglial CXCR4 in the pathogenesis of neuropathic pain using pSNL and CPIP models. Our results offer insights for the future research on CXCL12/CXCR4 axis and neuropathic pain therapy. | yes |
19187599 | Is inducible nitric oxide synthase involved in the oxidation stress induced by HIV-1 gp120 in human retina pigment epithelial cells? | [
"The human immunodeficiency virus-1 (HIV-1) envelope glycoprotein gp120 has been implicated in the development of AIDS-associated retinopathy. The present study tested the hypothesis that gp120 may induce oxidative stress including up regulation of inducible nitric oxide synthase (iNOS) and production of malondiald... | Gp120 induces oxidative stress in D407 cell by stimulating MDA and NO production, which is mediated by up-regulating iNOS expression. Gp120 may mediate oxidation stress in AIDS-associated retinopathy. | yes |
23468366 | Is rNA in blood altered prior to hemorrhagic transformation in ischemic stroke? | [
"Hemorrhagic transformation (HT) is a major complication of ischemic stroke that worsens outcomes and increases mortality. Disruption of the blood-brain barrier is a central feature of HT pathogenesis, and leukocytes may contribute to this process. We sought to determine whether ischemic strokes that develop HT hav... | Identified genes correspond to differences in inflammation and coagulation that may predispose to HT in ischemic stroke. Given the adverse impact of HT on stroke outcomes, further evaluation of the identified genes and pathways is warranted to determine their potential as therapeutic targets to reduce HT and as markers... | yes |
20308921 | Are hypertensive effects of central angiotensin II infusion and restraint stress reduced with age? | [
"We investigated the effect of age on cardiovascular responses mediated by central angiotensin II (AngII) after intracerebroventricular infusion of AngII, and during restraint stress.",
"Blood pressure (BP) and heart rate (HR) of young (5-month-old) and old (27-month-old) male Fischer-344 x Brown-Norway rats were... | This study demonstrates that the role of central AngII diminishes with age in the regulation of BP both during baseline conditions and during stress, whereas the involvement of AngII in the regulation of HR remains unaffected. | yes |
22524328 | Do mast cells act as phagocytes against the periodontopathogen Aggregatibacter actinomycetemcomitans? | [
"Evidence to date shows that mast cells play a critical role in immune defenses against infectious agents, but there have been no reports about involvement of these cells in eliminating periodontopathogens. In this study, the phagocytic ability of mast cells against Aggregatibacter actinomycetemcomitans compared wi... | This is the first report about the participation of murine mast cells as phagocytes against A. actinomycetemcomitans, mainly in the absence of opsonization with human serum. Our results may indicate that mast cells act as professional phagocytes in the pathogenesis of biofilm-associated periodontal disease. | yes |
18070752 | Does ghrelin enhance in vivo skeletal muscle but not liver AKT signaling in rats? | [
"Ghrelin administration can induce fat weight gain and hyperglycemia (potentially through ghrelin-induced hepatic glucose production), but plasma ghrelin is positively associated with whole-body insulin sensitivity (mainly reflecting muscle insulin action) being increased in lean individuals or after diet-induced w... | Despite moderate weight gain and in the absence of insulin-free fatty acid changes, sustained ghrelin administration enhanced oxidative muscle AKT activation. Reduced liver AKT signaling could potentially contribute to concomitant blood glucose increments. These findings support ghrelin as a novel tissue-specific modul... | yes |
18972606 | Does in utero exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin affect the development of reproductive system in mouse? | [
"Exposure of male reproductive organs to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) has been reported to cause developmental changes. In this study, we evaluated the effects of in utero TCDD exposure on male reproductive development.",
"Pregnant C57BL/6 mice were administered a single intraperitoneal injection of... | These results suggest that in utero exposure to TCDD influences the development of testes by inhibiting the expression of AR and PCNA. Moreover, the adverse effects of TCDD on male offspring reduced over time. | yes |
17909155 | Is binge eating associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia? | [
"Neurophysiologic studies on human and nonhuman primates implicate an orbitofrontal-insular-striatal circuit in high-level regulation of feeding. However, the role of these areas in determining feeding disturbances in neurologic patients remains uncertain.",
"To determine brain structures critical for control of ... | Binge eating can occur despite reported satiety and is associated with damage to a right-sided orbitofrontal-insular-striatal circuit in humans. These findings support a model in which ventral insular and orbitofrontal cortices serve as higher-order gustatory regions and cooperate with the striatum to guide appropriate... | yes |
26574858 | Does modal damping factor detected with an impulse-forced vibration method provide additional information on osseointegration during dental implant healing? | [
"To evaluate whether resonance frequency (RF) analysis combined with modal damping factor (MDF) analysis provides additional information on dental implant healing status.",
"In in vitro tests, epoxy resin was used to simulate the implant healing process. The RF and MDF values of the implants were measured during ... | Analysis of RF combined with MDF provides additional information on dental implant healing status. MDF analysis can detect changes in the implant/bone complex during the healing period even in implants with higher RF values. | yes |
12352477 | Does female gender protect blunt trauma patients from complications and mortality? | [
"The protective effect of gender on posttraumatic mortality or acute complications (acute respiratory distress syndrome [ARDS], pneumonia, and sepsis) is unclear. To assess potential effects, we performed a retrospective case-controlled study, matching patients for injury factors including overall severity (Injury ... | We conclude that female gender offers no protection from the development of ARDS, pneumonia, sepsis, or decreased mortality after blunt trauma. | no |
12198015 | Is plasma cholecystokinin associated with subjective measures of satiety in women? | [
"Cholecystokinin is associated with satiety. Fat stimulates cholecystokinin release, and fiber appears to prolong cholecystokinin elevation during the alimentary period.",
"We tested whether adding fiber or fat to a low-fat, low-fiber meal increases cholecystokinin release and enhances subjective measures of sati... | In women, the feeling of satiety caused by cholecystokinin release is enhanced by increasing either the fiber or fat content of a low-fat, low-fiber meal. | yes |
19172353 | Is laparoscopic Nissen fundoplication a good option in patients with abnormal esophageal motility? | [
"Patients with gastroesophageal reflux disease (GERD) and abnormal esophageal motility are the most controversial subgroup of surgically treated patients because of potentially increased risk of postoperative dysphagia. Our study aim was to determine if Nissen fundoplication is associated with increased postoperati... | This retrospective study found equally low rates of dysphagia following Nissen fundoplication regardless of baseline esophageal motility. Preoperative esophageal dysmotility therefore does not seem to be a contraindication for laparoscopic Nissen fundoplication. | yes |
19208363 | Do tGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway? | [
"During colorectal cancer pathogenesis, mutations and epigenetic events cause neoplastic behavior in epithelial cells by deregulating the Wnt, Ras-Raf-extracellular signal-regulated kinase (ERK), and transforming growth factor (TGF)-beta-signaling pathways, among others. The TGF-beta-signaling pathway is often inac... | A combination of inactivation of the TGF-beta-signaling pathway and expression of oncogenic Kras leads to formation of invasive intestinal neoplasms through a beta-catenin-independent pathway; these adenocarcinomas have the capacity to metastasize. | yes |
15711268 | Does ultrasensitive serum prostate specific antigen nadir accurately predict the risk of early relapse after radical prostatectomy? | [
"Ultrasensitive prostate specific antigen (PSA) assays allow a lower limit of detection (less than 0.01 ng/ml) than standard PSA assays. In this study we examined the ability of ultrasensitive PSA nadir to predict relapse after radical prostatectomy (RP).",
"A total of 906 men treated with RP were followed with P... | Ultrasensitive PSA nadir accurately predicts the risk of early biochemical relapse following RP. Men who achieve a nadir of less than 0.01 ng/ml have a low likelihood of early relapse. Higher nadir points may identify candidates for early adjuvant or salvage therapies. | yes |
23891097 | Does high NOTCH activity induce radiation resistance in non small cell lung cancer? | [
"Patients with advanced NSCLC have survival rates <15%. The NOTCH pathway plays an important role during lung development and physiology but is often deregulated in lung cancer, making it a potential therapeutic target. We investigated NOTCH signaling in NSCLC and hypothesized that high NOTCH activity contributes t... | We demonstrate an important role for NOTCH in tumor growth and correlate high NOTCH activity with poor prognosis and radioresistance. Blocking NOTCH activity in NSCLC might be a promising intervention to improve outcome after radiotherapy. | yes |
25761499 | Does compared with feeding infants breast milk or cow-milk formula , soy formula feeding affect subsequent reproductive organ size at 5 years of age? | [
"Literature reports suggest that phytochemicals, such as isoflavones found in soybeans, impair reproductive function in animals and raise the possibility that consuming soy infant formula could alter hormonally sensitive organ development in children.",
"This study compared reproductive organs volumes and structu... | In this cohort, no early infant feeding effects were found on reproductive organs volumes and structural characteristics in children age 5 y. The follow-up of these children through puberty is planned and should help delineate potential early infant feeding effect on reproductive function later in life. | no |
27320368 | Does higher Pretreatment Blood Pressure be Associated With Greater Posttraumatic Stress Disorder Symptom Reduction in Soldiers Treated With Prazosin? | [
"In a previously reported positive randomized controlled trial of the α",
"Effects of baseline standing systolic and other BP parameters on PTSD outcome measures from the previously reported randomized controlled trial were analyzed using linear mixed-effects models. Prazosin participants (n = 32) and placebo par... | These findings suggest that higher standing BP is a biomarker that helps identify persons with combat PTSD who are likely to benefit from prazosin. These results also are consistent with α | yes |
24502808 | Does carvacrol prevent methotrexate-induced renal oxidative injury and renal damage in rats? | [
"The purpose of this study was to investigate the effect of carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats.",
"Twenty-four male rats were equally divided into three groups: group I, control treatment; group II, MTX-treated; and group III, MTX+CAR-treated. A single dose of CAR (73 mg/kg) was ad... | MTX treatment results in oxidative damage to the rat kidney; damage which is partially abrogated by the administration of CAR. | yes |
22608065 | Does poor attention rather than hyperactivity/impulsivity predict academic achievement in very preterm and full-term adolescents? | [
"Very preterm (VP) children are at particular risk for attention deficit/hyperactivity disorder (ADHD) of the inattentive subtype. It is unknown whether the neurodevelopmental pathways to academic underachievement are the same as in the general population. This study investigated whether middle childhood attention ... | Attention is an important prerequisite for learning and predicts long-term academic underachievement. As ADHD inattentive subtype and cognitive impairments are frequent in VLBW/VP children, their study may help to identify the neurofunctional pathways from early brain development and dysfunction to attention problems a... | yes |
9209967 | Are responses to norepinephrine of normal and `` ischemic '' canine Purkinje fibers consistent with activation of different alpha 1-receptor subtypes? | [
"Previously we found that WB4101 (WB) 10(-7) M competitively blocks three alpha 1-adrenergic receptor-effector responses: the increase in normal automaticity occurring in Purkinje fibers (PF) at high membrane potentials; the increase in abnormal automaticity occurring in PF at depolarized membrane potentials; and t... | (1) A single receptor subtype appears responsible for both the alpha 1-induced prolongation of repolarization and the positive chronotropic effect in normal PF. (2) Two different receptor subtypes may be responsible for the alpha 1-induced effects on automaticity in normal and ischemic fibers. It is likely that the lat... | yes |
15485752 | Is hypertension in overweight and obese primary care patients highly prevalent and poorly controlled? | [
"Although the relationship between body weight and blood pressure (BP) is well established, there is a lack of data regarding the impact of obesity on the prevalence of hypertension in primary care practice. The objective of this study was to assess the prevalence of hypertension and the diagnosis, treatment status... | The increasing prevalence of hypertension in obese patients and the low control rates in overweight and obese patients document the challenge that hypertension control in obese patients imposes on the primary care physician. These results highlight the need for specific evidence-based guidelines for the pharmacologic m... | yes |
25194295 | Does adverse left ventricular remodeling in community-dwelling older adults predict incident heart failure and mortality? | [
"This study sought to determine whether specific patterns of adverse left ventricular (LV) structural remodeling are associated with differential rates of cardiovascular (CV) outcomes.",
"It is not known whether a stepwise combinatorial assessment of LV volume, mass, and geometry done to define specific remodelin... | Stepwise combinatorial assessment of LV volume, mass, and geometry provides incremental prognostic information regarding CV outcomes. | yes |
24995887 | Does prevalence and correlate of DSM-5 bipolar and related disorders and hyperthymic personality in the community? | [
"To 1) establish the lifetime and 12-month prevalence of DSM-5 bipolar and related disorders including the new algorithmically defined conditions grouped within Other Specified Bipolar and Related Disorders (OSBARD) as well as hyperthymic personality in a randomly selected community sample, and 2) determine the cli... | Small sample sizes for bipolar and related disorders and potential inaccurate recall of symptoms. | yes |
24552980 | Does low-volume high-intensity interval training rapidly improve cardiopulmonary function in postmenopausal women? | [
"This study compared the effects of a 2-week program of low-volume high-intensity interval training (HIT) with the effects of higher-volume moderate-intensity continuous training (CT) on cardiopulmonary and vascular functions in postmenopausal women.",
"Twenty-two postmenopausal women were randomly assigned to un... | The findings suggest that low-volume HIT is feasible and can lead to rapid improvements in cardiopulmonary function in postmenopausal women. | yes |
8836268 | Does response to double-burst appear before response to train-of-four stimulation during recovery from non-depolarizing neuromuscular blockade? | [
"Double-burst stimulation (DBS) it a relatively new nerve stimulation mode introduced for improved manual detection of residual neuromuscular blockade. Previous studies have shown that DBS3,3 50/50 (3 stimuli at 50 Hz followed 0.75 seconds later by 3 stimuli at 50 Hz) can detect deeper degrees of neuromuscular bloc... | DBS3,3 80/40 is capable of detecting deeper degrees of blockade than DBS3,3 50/50, which again is capable of detecting deeper degrees of blockade than TOF. | yes |
27824693 | Does aerobic Exercise Training improve Orthostatic Tolerance in Aging Humans? | [
"This study was designed to test the hypothesis that aerobic exercise training of the elderly will increase aerobic fitness without compromising orthostatic tolerance (OT).",
"Eight healthy sedentary volunteers (67.0±1.7 years old, 4 women) participated in 1-year of endurance exercise training (stationary bicycle... | Aerobic exercise training improved the aerobic fitness and OT in elderly subjects. An improved OT is likely associated with an enhanced CBR function that has been reset to better maintain cerebral perfusion and cerebral tissue oxygenation during LBNP. | yes |
12767664 | Is hypertrophic cardiomyopathy due to sarcomeric gene mutations characterized by impaired energy metabolism irrespective of the degree of hypertrophy? | [
"We investigated cardiac energetics in subjects with mutations in three different familial hypertrophic cardiomyopathy (HCM) disease genes, some of whom were nonpenetrant carriers without hypertrophy, using phosphorus-31 magnetic resonance spectroscopy.",
"Familial hypertrophic cardiomyopathy is caused by mutatio... | Our data provide evidence of a bioenergetic deficit in genotype-confirmed HCM, which is present to a similar degree in three disease-gene groups. The presence of energetic abnormalities, even in those without hypertrophy, supports a proposed link between altered cardiac energetics and development of the disease phenoty... | yes |
23999331 | Does post-discharge surveillance of wound infections by telephone call method in a Sudanese Teaching Hospital? | [
"Surveillance of wound infections has been shown to be a powerful preventive tool, and feedback to the clinical staff reduces wound infection rates. The main objectives of this study were to identify the applicability of telephone calls as a method of post-discharge wound infection surveillance, and to identify pat... | The majority of wound infections in the current study appeared in post-discharge period; this emphasis the need for establishment of surveillance program in the hospital. Surveillance of wound infections using telephone calls is applicable in this setting and can be used as an alternative method to clinic-based diagnos... | yes |
15809286 | Does focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicate cardiac involvement of sarcoidosis? | [
"To evaluate the value of (18)F-fluoro-2-deoxyglucose positron emission tomography ((18)F-FDG PET) in detecting cardiac sarcoidosis.",
"Thirty-two patients with sarcoidosis and thirty controls were recruited. All subjects underwent cardiac (18)F-FDG PET after a 6 h fasting period, and subjects with sarcoidosis un... | Focal uptake of the heart on (18)F-FDG PET images is a characteristic feature of patients with sarcoidosis. Furthermore, (18)F-FDG PET has the potential to detect cardiac sarcoidosis that cannot be diagnosed by (67)Ga or (99m)Tc-MIBI scintigraphy. | yes |
22824143 | Does ephrin-A1 inhibit NSCLC tumor growth via induction of Cdx-2 a tumor suppressor gene? | [
"Tumor formation is a complex process which involves constitutive activation of oncogenes and suppression of tumor suppressor genes. Receptor EphA2 and its ligand ephrin-A1 form an important cell communication system with its functional role in cell-cell interaction and tumor growth. Loss of cell-cell adhesion is c... | Our study suggests that EphA2 signaling up-regulates the expression of the TJ-protein claudin-2 that plays an important role in promoting cell proliferation and tumor growth in NSCLC cells. We conclude that receptor EphA2 activation by ephrin-A1 induces tumor suppressor gene cdx-2 expression which attenuates cell proli... | yes |
19076287 | Are advanced oxidative protein products independently associated with endothelial function in peritoneal dialysis patients? | [
"Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as non-classical cardiovascular risk factors in end-stage renal disease patients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with endothelial function (EF) in peritoneal... | This study shows that PD patients without known atherosclerotic disease can also be characterized by endothelial dysfunction and AOPP levels independently predict endothelial function level in PD patients. | yes |
22276092 | Is preoperative proteinuria associated with long-term progression to chronic dialysis and mortality after coronary artery bypass grafting surgery? | [
"Preoperative proteinuria is associated with post-operative acute kidney injury (AKI), but whether it is also associated with increased long-term mortality and end-stage renal disease (ESRD) is unknown.",
"We studied 925 consecutive patients undergoing CABG. Demographic and clinical data were collected prospectiv... | Our study demonstrated that proteinuria is a powerful independent risk factor of long-term all-cause mortality and ESRD after CABG in addition to preoperative GFR and postoperative AKI. Our study demonstrated that proteinuria should be integrated into clinical risk prediction models for long-term outcomes after CABG. T... | yes |
24306900 | Does the right ventricle explain sex differences in survival in idiopathic pulmonary arterial hypertension? | [
"Male sex is an independent predictor of worse survival in pulmonary arterial hypertension (PAH). This finding might be explained by more severe pulmonary vascular disease, worse right ventricular (RV) function, or different response to therapy. The aim of this study was to investigate the underlying cause of sex d... | This study suggests that differences in RVEF response with initiation of medical therapy in idiopathic PAH explain a significant portion of the worse survival seen in men. | yes |
17892553 | Does heat shock inhibit lipopolysaccharide-induced tissue factor activity in human whole blood? | [
"During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients. There are indications, that fever reduces the mortality of sepsis, the effect on tissue fa... | Heat shock treatment inhibits LPS-induced tissue factor activity in human whole blood samples and isolated leukocytes. | yes |
25678599 | Do the Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells? | [
"The WW domain containing oxidoreductase (WWOX) has recently been shown to inhibit of the Wnt/β-catenin pathway by preventing the nuclear import of disheveled 2 (DVL2) in human breast cancer cells. Here, it is revealed that WWOX also interacts with the BCL9-2, a cofactor of the Wnt/β-catenin pathway, to enhance the... | The inhibition of the transcriptional activity of BCL9-2 by WWOX and HDAC3 constitutes a new molecular mechanism and provides new insight for a broad range of cancers. | yes |
20690561 | Is hepatitis C genotype 4 response rate to pegylated interferon and ribavirin treatment in Belgium similar to genotype 1? | [
"Patients with genotype 4 (G4) chronic hepatitis C from the Middle East respond better to treatment than genotype 1 (G1) patients. There are few data on the response rates to treatment of G4 patients living in Western Europe. Many G4 patients in Belgium originate from Central Africa, and their response to treatment... | G4 patients in Belgium have the same SVR as G1 patients. It is lower than the SVR described in Arab countries, especially for Black G4 patients. | yes |
25249236 | Are rb and p107 required for alpha cell survival , beta cell cycle control and glucagon-like peptide-1 action? | [
"Diabetes mellitus is characterised by beta cell loss and alpha cell expansion. Analogues of glucagon-like peptide-1 (GLP-1) are used therapeutically to antagonise these processes; thus, we hypothesised that the related cell cycle regulators retinoblastoma protein (Rb) and p107 were involved in GLP-1 action.",
"W... | We found a central role of Rb in the dual effects of GLP-1 in alpha and beta cells. Our findings highlight unique contributions of individual Rb family members to islet cell proliferation and survival. | yes |
22430524 | Do catastrophic failure after open reduction internal fixation of femoral neck fractures with a novel locking plate implant? | [
"To determine if the use of a novel proximal femoral locking plate could reduce the incidence of femoral neck shortening and improve clinical outcomes after open reduction internal fixation (ORIF) for femoral neck fractures as compared with historical controls.",
"Single surgeon, retrospective case-control study.... | ORIF of femoral neck fractures using a locking plate construct yielded unacceptably poor outcomes in this patient population. We hypothesize that the stiffness of this construct prevents any fracture site micromotion, placing the mechanical burden on the implant, which can result in failure at the bone-screw interface ... | yes |
20920032 | Are why carers of frail older people using available respite services : an Australian study? | [
"The purpose of this study was to explore the limiting and motivating factors that influence carers' use of respite services and the ability of currently available respite services to meet the needs of carers of frail older people.",
"The development of community carer support services, their availability and usa... | This study improves our understanding of the caring role, its significance in carer's lives and how this shapes their formal service expectations and use. The findings suggest that further investigation of the factors involved in carers' service expectations and service-seeking is warranted to develop a deeper understa... | no |
16762055 | Does independent component analysis reveal new and biologically significant structures in micro array data? | [
"An alternative to standard approaches to uncover biologically meaningful structures in micro array data is to treat the data as a blind source separation (BSS) problem. BSS attempts to separate a mixture of signals into their different sources and refers to the problem of recovering signals from several observed l... | Although the ICA approach primarily detects hidden variables, these surfaced as highly correlated genes in time series data and in one instance in the tumor data. This further strengthens the biological relevance of latent variables detected by ICA. | yes |
21528028 | Does effect of axial groove and resin luting cement on the retention of complete cast metal crowns? | [
"The design of the tooth preparation and the cementing medium are important consid-erations in the retention of crowns and fixed partial dentures. The purpose of this invitro study was to determine the effect of axial groove on the retention of complete cast metal crowns using two resin luting cements.",
"Forty f... | Axial groove placed in tooth preparations for resin bonded complete cast metal crowns had no statistically significant effect on retention. The use of (RelyX Unicem®) yielded greater retention values when compared to Calibra®. | yes |
22057491 | Does tumor response to mTHPC-mediated photodynamic therapy exhibit strong correlation with extracellular release of HSP70? | [
"We investigated the relationship among heat shock protein 70 (hsp70) promoter activation, extracellular HSP70 protein levels, and tumor cure in an animal model of meso-tetrahydroxyphenyl chlorin (mTHPC; Foscan®)-mediated photodynamic therapy (PDT).",
"Using Western blot analysis, we compared HSP70 protein levels... | Treatment conditions that induce strong promoter activation do not correspond to tumor cure. PDT doses that result in long-term tumor growth control also produce significant accumulation of extracellular HSP70. | yes |
19830720 | Are early elevations in B-type natriuretic peptide levels associated with poor clinical outcomes in pediatric acute lung injury? | [
"To determine B-type natriuretic peptide (BNP) levels in infants and children with acute lung injury (ALI), and to investigate associations between BNP levels and clinical outcome.",
"Prospective observational study.",
"After informed consent, plasma was collected from 48 pediatric patients on day 1 of ALI.",
... | BNP levels are elevated in children with ALI/ARDS early in the disease course, and increased levels are associated with worse clinical outcome. | yes |
24522227 | Does core drug-drug interaction alert for inclusion in pediatric electronic health records with computerized prescriber order entry? | [
"The study aims to develop a core set of pediatric drug-drug interaction (DDI) pairs for which electronic alerts should be presented to prescribers during the ordering process.",
"A clinical decision support working group composed of Children's Hospital Association (CHA) members was developed. CHA Pharmacists and... | We have provided a core list of 19 high value drug pairs for electronic drug-drug interaction alerts to be recommended for inclusion as high value alerts in prescriber order entry software used with a pediatric patient population. We believe this list represents the most important pediatric drug interactions for practi... | yes |
27525223 | Do computerized techniques pave the way for drug-drug interaction prediction and interpretation? | [
"Health care industry also patients penalized by medical errors that are inevitable but highly preventable. Vast majority of medical errors are related to adverse drug reactions, while drug-drug interactions (DDIs) are the main cause of adverse drug reactions (ADRs). DDIs and ADRs have mainly been reported by hapha... | A better understanding of DDIs not only provides a robust means for designing more effective medicines but also grantees patient safety. | yes |
11713905 | Is fK506 superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis? | [
"The anti-arthritic properties of FK506 were compared with methotrexate (MTX) in established adjuvant-induced arthritis (AIA) in rats.",
"Female Lewis rats.",
"Arthritic rats were orally administered with FK506 (1-5.6 mg/kg) and MTX (0.1-1 mg/kg) from days 15-24.",
"Arthritis was induced by injection of Mycob... | The results show that FK506 is more effective and less toxic than MTX in treating established AIA in rats. | yes |
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