id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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26553429 | Is obesity associated with increased postoperative complications after operative management of tibial shaft fractures? | [
"To assess the association of obesity and postoperative complications after operative management of tibial shaft fractures.",
"Patients who underwent operative management of a tibial shaft fracture were identified in a national database by Current Procedural Terminology (CPT) codes for: (1) open reduction and int... | In patients who undergo either ORIF or IMN for tibial shaft fractures, obesity and its related medical comorbidities are associated with significantly increased rates of postoperative medical complications, infection, nonunion, and implant removal compared to non-obese patients. | yes |
19275777 | Does overexpression of cyclin E messenger ribonucleic acid in nasopharyngeal carcinoma correlate with poor prognosis? | [
"S-phase kinase-associated protein 2 is required for the degradation of p27 protein, which is a negative regulator of cyclin E/cyclin-dependent kinase 2 complex. The present study examined the expression of cyclin E, S-phase kinase-associated protein 2 and p27 protein in nasopharyngeal carcinoma.",
"Tissue from 3... | Overexpression of cyclin E messenger ribonucleic acid showed an adverse prognostic significance, correlating with an advanced stage of nasopharyngeal carcinoma and a low overall survival rate. | yes |
26551933 | Is functional dyspepsia associated with GNβ3 C825T and CCK-AR T/C polymorphism? | [
"A polymorphism (C825T) in G-protein β polypeptide-3 (GNβ3) gene alters intracellular signal transduction, which may cause motor or sensory abnormalities in the gastrointestinal tract. Cholecystokinin-A receptor (CCK-AR) gene T/C polymorphism is associated with a defective splicing of the primary transcript of CCK-... | TT genotype of GNβ3 C825T is more common among patients with FD than among HC, suggesting that increased signal transduction associated with this genotype may be important in its pathophysiology. However, CCK-AR polymorphism is protective against FD. | yes |
25752462 | Are low serum vitamin D levels associated with increased postoperative pain and opioid requirements : a historical cohort study? | [
"Vitamin D deficiency has been associated with chronic non-specific musculoskeletal pain syndromes; however, studies are lacking with respect to its relationship with postoperative pain. We tested the hypothesis that a lower preoperative vitamin D level is associated with increased postoperative pain and/or opioid ... | We did not find any association between preoperative vitamin D levels and postoperative pain scores/opioid consumption in morbidly obese patients undergoing bariatric surgery. | no |
20667357 | Does surgical approach for aortic coarctation influence arterial compliance and blood pressure control? | [
"Increased arterial stiffness is linked to hypertension in adults after surgical repair for coarctation of the aorta. We evaluated the influence of surgical approaches, namely, subclavian flap repair (SFR) and end-to-end anastomosis (EEA), on arterial stiffness, blood pressure, cardiac output, and cardiac barorecep... | Young children undergoing SFR have higher blood pressure and stiffer upper limb arteries compared with matched children undergoing EEA. Our data suggest that better longer-term cardiovascular outcome is to be expected with the EEA surgical approach. | yes |
27698954 | Do korean pine nut oil replacement decreases intestinal lipid uptake while improves hepatic lipid metabolism in mice? | [
"Consumption of pine nut oil (PNO) was shown to reduce weight gain and attenuate hepatic steatosis in mice fed a high-fat diet (HFD). The aim of this study was to examine the effects of PNO on both intestinal and hepatic lipid metabolism in mice fed control or HFD.",
"Five-week-old C57BL/6 mice were fed control d... | PNO replacement in the diet might function in prevention of excessive lipid uptake by intestine and improve hepatic lipid metabolism in both control diet and HFD fed mice. | yes |
26456703 | Does celecoxib interfere to a limited extent with aspirin-mediated inhibition of platelets aggregation? | [
"The aim of the study was to analyze the interaction between celecoxib and low dose aspirin for COX-1 binding and its consequences on the aspirin-mediated antiplatelet effects.",
"We investigated ex vivo the interaction between celecoxib and aspirin for COX-1 binding and measured the resulting antiplatelet effect... | At the recommended therapeutic doses, celecoxib can attenuate to a limited extent the in vivo antiplatelet effects of low dose aspirin. Patients receiving a combination of low dose aspirin and the recommended doses of celecoxib were not identified to have increased risk of cardiovascular and cerebrovascular events due ... | yes |
16641874 | Is brain natriuretic peptide a reliable indicator of ventilatory abnormalities during cardiopulmonary exercise test in heart failure patients? | [
"Whether brain natriuretic peptide (BNP), a neurohormone marker of ventricular dysfunction, correlates with an enhanced ventilatory response (EVR) during cardiopulmonary exercise test, a well-known predictor of prognosis, in systolic heart failure (HF) is currently unknown.",
"Resting BNP was measured in 134 cons... | In systolic HF, plasma BNP is related to an enhanced ventilatory response to exercise and offers a simple and reliable alternative to the cardiopulmonary exercise test in patients with inability or contraindications to exercise. | yes |
24418903 | Is the commensal bacterium Faecalibacterium prausnitzii protective in DNBS-induced chronic moderate and severe colitis models? | [
"The abundance of Faecalibacterium prausnitzii, an abundant and representative bacterium of Firmicutes phylum, has consistently been observed to be lower in patients with Crohn's disease than in healthy individuals. We have shown that both F. prausnitzii and its culture supernatant (SN) have anti-inflammatory and p... | We show, for the first time, protective effects of both F. prausnitzii and its SN during both the period of recovery from chronic colitis and colitis reactivation. These results provide further evidence that F. prausnitzii is an anti-inflammatory bacterium with therapeutic potential for patients with inflammatory bowel... | yes |
25586835 | Do genes from a translational analysis support a multifactorial nature of white matter hyperintensities? | [
"White matter hyperintensities (WMH) of presumed vascular origin increase the risk of stroke and dementia. Despite strong WMH heritability, few gene associations have been identified. Relevant experimental models may be informative.",
"We tested the associations between genes that were differentially expressed in... | Despite not passing multiple testing thresholds individually, these genes collectively are relevant to known WMH associations, proposed WMH mechanisms, or dementia: associations with Alzheimer's disease, late-life depression, ATP production, osmotic regulation, neurodevelopmental abnormalities, and cognitive impairment... | yes |
12813269 | Does venoarterial extracorporeal membrane oxygenation impair basal nitric oxide production in cerebral arteries of newborn lambs? | [
"Based on previous studies in our laboratory showing that exposure of newborn lambs to venoarterial extracorporeal membrane oxygenation (ECMO) alters cerebral blood flow autoregulation, we postulated that this altered vascular reactivity is mediated through changes in endothelial function caused by the pumping syst... | These results demonstrate that 2 hrs of exposure of newborn lambs to venoarterial ECMO leads to a decrease in basal production of nitric oxide in cerebral arteries, and suggest that venoarterial ECMO selectively impairs cerebral arterial endothelial function. | yes |
25729548 | Do vitamin D3 influence the Th1/Th2 ratio in C57BL/6 induced model of experimental autoimmune encephalomyelitis? | [
"Multiple Sclerosis (MS) is known as a progressive inflammatory CNS disease. Cytokines belong to Th1 or Th2 family and inflammatory cells, play significant role in pathophysiology of MS. Thus, any treatment supposed to influence the relation between Th1 to Th2 cytokines expression. Although vitamin D has been presc... | According to the results, vitamin D3 may be able to suppress the inflammatory ways that lead to progression of MS. Whether this ability is clinically valuable in human subjects is not clear and needs more clinical research. | yes |
22590500 | Does a single nucleotide polymorphism within the novel sex-linked testis-specific retrotransposed PGAM4 gene influence human male fertility? | [
"The development of novel fertilization treatments, including in vitro fertilization and intracytoplasmic injection, has made pregnancy possible regardless of the level of activity of the spermatozoa; however, the etiology of male-factor infertility is poorly understood. Multiple studies, primarily through the use ... | These results suggest that PGAM4, an X-linked retrogene, is a fundamental gene in human male reproduction and may escape meiotic sex chromosome inactivation. These findings provide fresh insight into elucidating the mechanisms of male infertility. | yes |
26378385 | Is isoprene in the Exhaled Breath a Novel Biomarker for Advanced Fibrosis in Patients with Chronic Liver Disease : A Pilot Study? | [
"Analysis of volatile organic compounds (VOCs) in the exhaled breath can identify markers for alcoholic and nonalcoholic fatty liver disease. The aim of this pilot study was to investigate the utility of breath VOCs measured by mass spectrometry to diagnose advanced fibrosis in patients with chronic liver disease (... | Isoprene is a potential biomarker for advanced fibrosis that deserves further validation. | yes |
22261091 | Are serum levels of leptin , adiponectin and resistin interrelated and related to total antioxidant capacity , free fatty acids and phospholipids in early neonatal life? | [
"The aims of this study were to determine interrelationships between serum leptin, adiponectin and resistin, insulin-like growth factor-1 (IGF-1), total antioxidant capacity (TAC), non-esterified fatty acids (NEFA) and phospholipids concentrations in infants.",
"A cross-sectional study was conducted to assess ser... | These data show that circulatory levels of leptin, adiponectin and resistin are interrelated and they apparently interact with the anti-oxidant system of infants. | yes |
19695569 | Is soluble VEGF receptor-2 increased in sera of subjects with metabolic syndrome in association with insulin resistance? | [
"Metabolic syndrome (MetS) is associated with impaired angiogenesis. Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis through binding to its specific receptor, VEGF receptor-2 (VEGFR-2), whereas the expression of VEGF and VEGFR-2 in the myocardium of insulin-resistant rats is down-regulate... | The correlation of sVEGFR-2 with insulin resistance supports the need for further investigations to define the clinical utility and predictive value of serum sVEGFR-2 levels in cardiovascular dysfunction in MetS. | yes |
26853806 | Is migraine related to an increased risk of Parkinson 's disease : A population-based , propensity score-matched , longitudinal follow-up study? | [
"The association between migraine and Parkinson's disease (PD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether migraineurs are at a higher risk of developing PD.",
"A total of 41,019 subjects aged between 40 and 90 years with ... | This study showed an increased risk of developing PD in patients with migraine. | yes |
23952188 | Is baseline severity of parent-perceived inattentiveness predictive of the difference between subjective and objective methylphenidate responses in children with attention-deficit/hyperactivity disorder? | [
"The purpose of this study was to find potential variables associated with the difference between subjective and object treatment responses in children with attention-deficit/hyperactivity disorder (ADHD) treated with OROS-methylphenidate (MPH).",
"We conducted a post-hoc analysis of data from a multicenter, open... | The baseline severity of parent-perceived inattentive symptoms was predictive of differences in subjective and objective treatment responses, and the baseline severity of neuropsychological deficit (inattention and inconsistency of attention) was predictive of responses, using both subjective and objective measurements... | yes |
22735711 | Are de novo DQ donor-specific antibodies associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy? | [
"The importance of human leukocyte antigen (HLA) matching in renal transplantation is well recognized, with HLA-DR compatibility having the greatest influence. De novo DQ donor-specific antibodies (DSAbs) are the predominant HLA class II DSAb after transplantation. The aim of this study was to establish the inciden... | DQ DSAbs are associated with inferior allograft outcomes. This study shows the importance of establishing the DQ match before transplantation to define immunologic risk. | yes |
23985230 | Do intentions modify program impact after a nutrition education intervention? | [
"To examine whether expressed intentions modified program impact on diet.",
"A nutrition education intervention was conducted with African American women in Washington, DC. Dietary recalls and surveys at post-intervention and follow-up were analyzed.",
"At 20-week follow-up, frequent attenders reported .13 more... | Sustained intentions predicted dietary change, informing measurement and theory for nutrition interventions. | yes |
25414154 | Is neuronal T-cell autoreactivity amplified in overweight children with new-onset insulin-requiring diabetes? | [
"Disease-associated T-cell autoreactivities are seen in most type 1 diabetic patients and are thought to emerge before islet autoantibodies, but host factors that impact autoimmune elements remain uncertain. We assessed if adiposity and measures of insulin sensitivity impact T- and B-cell autoimmunity in children w... | Our observations link obesity and diabetes-related autoimmunity, suggesting an amplification of neuronal T-cell autoimmunity associated with adiposity and/or insulin resistance, with obesity-related inflammation possibly enhancing islet autoimmunity. | yes |
20470412 | Do beta2-agonists promote host defense against bacterial infection in primary human bronchial epithelial cells? | [
"Airway epithelial cells are critical in host defense against bacteria including Mycoplasma pneumoniae (Mp) in chronic obstructive pulmonary disease (COPD) and asthma. beta2-agonists are mainstay of COPD and asthma therapy, but whether beta2-agonists directly affect airway epithelial host defense functions is uncle... | These results for the first time show that beta2-agonists enhance host defense functions of primary bronchial epithelial cells from normal and asthma subjects, which is attenuated by IL-13. | yes |
10961177 | Are gastric mucosal inflammation and epithelial cell turnover associated with gastric cancer in patients with Helicobacter pylori infection? | [
"Infection with a virulent Helicobacter pylori strain is associated with gastric mucosal damage and the increased risk of gastric cancer.",
"To examine the characteristics of host gastric mucosal responses in patients with gastric cancer, histological grade of gastritis, gastric epithelial apoptosis, and prolifer... | Infection with H pylori causes increased gastric epithelial apoptosis, resulting in more severe glandular atrophy in patients with gastric cancer. Increased damage of gastric epithelial DNA and the presence of more severe atrophic gastritis might contribute to the development of gastric cancer. | yes |
11562666 | Is intradermal isotope injection superior to intramammary in sentinel node biopsy for breast cancer? | [
"The optimal sentinel lymph node (SLN) biopsy technique remains undefined in breast cancer. Injecting radiotracer or blue dye by a variety of routes seems to stage the axilla with comparable accuracy, and we have hypothesized that the dermal and the parenchymal lymphatics of the breast drain to the same SLN in most... | ID isotope injection identifies the SLN more often than IP, stages the axilla with comparable accuracy, and is associated with higher levels of SLN isotope uptake. The dermal and parenchymal lymphatics of the breast drain to the same axillary SLN in most breast cancer patients, and ID isotope injection is the procedure... | yes |
20675706 | Is anti-TNF therapy associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment : updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly? | [
"To evaluate the risk of serious infections (SIs) in patients with RA treated with anti-TNF therapy with emphasis on the risk across different ages.",
"Using data from the British Society for Rheumatology Biologics Register, a prospective observational study, we compared the risk of SI between 11 798 anti-TNF-tre... | These data add to currently available evidence suggesting that anti-TNF therapy is associated with a small but significant overall risk of SI. This must be balanced against the risks associated with poor disease control or alternative treatments. | yes |
25180256 | Does exome sequencing identify SLC17A9 pathogenic gene in two Chinese pedigrees with disseminated superficial actinic porokeratosis? | [
"Disseminated superficial actinic porokeratosis (DSAP) is a rare autosomal dominant genodermatosis characterised by annular lesions that has an atrophic centre and a prominent peripheral ridge distributed on sun exposed area. It exhibits high heterogeneity, and five linkage loci have been reported. The mevalonate k... | The result identified SLC17A9 as another pathogenic gene for DSAP, which suggests a correlation between the aberrant vesicular nucleotide transporter and the pathogenesis of DSAP. | yes |
27260343 | Does a novel regression model from RGB image data to spectroradiometric correlate optimized for tooth colored shades? | [
"Objectives of this study were to correlate RGB data from the VITA Linearguide 3D Master and VITA Bleached Guide 3D Master shade guides with their spectroradiometric correlates through a regression model while indicating a methodology for validation of accuracy of digital imaging systems. Additional objectives were... | A relationship between RGB and lightness for the shade guides was found. Regression models were developed that allow tooth color information to be translated from digital images to accurate shade tab correlates for color matching purposes in dentistry. This allows for optimal color accuracy when using digital imaging t... | yes |
26719725 | Is a GM-CSF and CD40L bystander vaccine effective in a murine breast cancer model? | [
"There is increasing interest in using cancer vaccines to treat breast cancer patients in the adjuvant setting to prevent recurrence in high risk situations or in combination with other immunomodulators in the advanced setting. Current peptide vaccines are limited by immunologic compatibility issues, and engineered... | The use of BCG bystander cell lines demonstrates proof of concept for anti-tumor activity and immunogenicity in an immunocompetent murine model of breast cancer. This vaccine is being evaluated in lung cancer and should be explored further in clinical trials of breast cancer patients at high risk of recurrence or in co... | yes |
23946296 | Does microRNA-31 predict the presence of lymph node metastases and survival in patients with lung adenocarcinoma? | [
"We conducted genome-wide miRNA-sequencing (miRNA-seq) in primary cancer tissue from patients of lung adenocarcinoma to identify markers for the presence of lymph node metastasis.",
"Markers for lymph node metastasis identified by sequencing were validated in a separate cohort using quantitative PCR. After additi... | We applied miRNA-seq to study microRNomes in lung adenocarcinoma tissue samples for the first time and potentially identified a miRNA predicting the presence of lymph node metastasis and survival outcomes in patients of lung adenocarcinoma. | yes |
22921303 | Does lycium barbarum polysaccharide stimulate proliferation of MCF-7 cells by the ERK pathway? | [
"The aim of this study was to investigate the anti-proliferative effect of Lycium barbarum polysaccharide (LBP) on MCF-7 cells.",
"MCF-7 cells were treated with 0, 10, 30, 100, and 300 μg/ml LBP for 24 h. The cell cycle distribution was analyzed by flow cytometry. MEK inhibitor, U1206 also was added in MCF-7 cell... | LBP induces the anti-proliferation of MCF-7 cells by activating ERK. | yes |
21617130 | Does endogenous muscle atrophy F-box mediate pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB? | [
"Overexpression of muscle atrophy F-box (MAFbx/atrogin-1), an E3 ubiquitin ligase, induces proteasomal degradation in cardiomyocytes. The role of endogenous MAFbx in regulating cardiac hypertrophy and failure remains unclear.",
"We investigated the role of MAFbx in regulating cardiac hypertrophy and function in r... | MAFbx plays an essential role in mediating cardiac hypertrophy in response to pressure overload. Downregulation of MAFbx inhibits cardiac hypertrophy in part through stabilization of IκB-α and inactivation of nuclear factor-κB. Taken together, inhibition of MAFbx attenuates pathological hypertrophy, thereby protecting ... | yes |
15850458 | Does p38 mitogen-activated protein kinase ( MAPK ) first regulate filamentous actin at the 8-16-cell stage during preimplantation development? | [
"The MAPK (mitogen-activated protein kinase) superfamily of proteins consists of four separate signalling cascades: the c-Jun N-terminal kinase or stress-activated protein kinases (JNK/SAPK); the ERKs (extracellular-signal-regulated kinases); the ERK5 or big MAPK1; and the p38 MAPK group of protein kinases, all of ... | Murine preimplantation development becomes dependent on p38 MAPK at the 8-16-cell stage, which corresponds to the stage when p38 MAPK first regulates filamentous actin during early development. | yes |
7837389 | Do allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma? | [
"Deletions in the short arm of chromosome 3 (3p) are present in most lung carcinomas.",
"To investigate the role of these chromosome 3p deletions in the pathogenesis of non-small cell lung carcinomas.",
"Seven archival, paraffin-embedded, surgically resected lung cancer specimens were studied. Fifty precisely i... | Deletions in the short arm of chromosome 3 occur at the earliest stage (hyperplasia) in the pathogenesis of lung cancer and involve all regions of the respiratory tract. Allele loss is highly specific, but its mechanism remains unknown. Our findings may be of considerable biologic, prognostic, and clinical significance... | yes |
10333035 | Do circuits with surface modifying additive alter the haemodynamic response to cardiopulmonary bypass? | [
"Blood contact with synthetic surfaces during cardiopulmonary bypass (CPB), inevitably results in the activation of a variety of interrelated pathways of inflammation and coagulation that may contribute to postoperative complications in cardiac surgery patients. The objective of this trial was to evaluate clinical ... | The decrease in blood pressure in the control group, upon the initiation of CPB, did not occur in patients undergoing CPB with the circuit prepared with the surface modifying additive. The decrease in blood pressure was likely associated with the increase in total administered fluids intraoperatively (approximately 1 l... | yes |
14993125 | Do morphine-tolerant mice exhibit a profound and persistent cardioprotective phenotype? | [
"Morphine and other opioids continue to be used as the major treatment for acute pain both before and after surgery. In this regard, much research has focused on the mechanisms of morphine tolerance and dependence in the central nervous system; however, few studies have examined the effect of morphine on peripheral... | These data demonstrate that chronic exposure to morphine unexpectedly results in a profound and persistent cardioprotective phenotype. | yes |
15002073 | Does perfusion temperature during cardiopulmonary bypass affect serum S-100beta release? | [
"The potentially harmful effects of normothermia on neurological outcome during cardiopulmonary bypass (CPB) are controversial.",
"In this study, we compared the early and late release patterns of S-100beta, a marker of cerebral injury, after normothermic and moderately hypothermic CPB. Forty-eight patients under... | The similar pattern of S-100beta release without evident neurological complications in the normothermia group does not suggest an increase in cerebral injury during normothermic CPB. | no |
17760882 | Is long-term GH treatment associated with disadvantageous changes of inflammatory markers and adipocytokines in children born small for gestational age? | [
"Low birth weight is associated with increased risks for adult cardiovascular disease (CVD) and diabetes mellitus type 2 (DM2). Adiponectin and resistin are hormones, considered, respectively, protective and disadvantageous regarding these risks. No data exist on the effect of long-term GH treatment on these hormon... | Long-term GH treatment is not associated with disadvantageous changes in adiponectin, resistin, IL-6 and CRP levels, neither during nor after GH treatment. | no |
19196499 | Are higher HDL cholesterol levels associated with a lower incidence of chronic kidney disease in patients with type 2 diabetes? | [
"Type 2 diabetes is one of the most important risk factor for the development of chronic kidney disease (CKD). Recently, it has been shown that lower high-density lipoprotein cholesterol (HDL-C) levels predicted the development of microalbuminuria in type 2 diabetic individuals. We have prospectively assessed the e... | Higher plasma levels of HDL-C are associated with a lower risk of incident CKD in a large cohort of type 2 diabetic adults independently of numerous confounding factors. | yes |
9749498 | Does anal sphincter integrity and function influence outcome in rectovaginal fistula repair? | [
"Traumatic sphincter disruption frequently is associated with a rectovaginal fistula, but the effect of a persistent sphincter defect on the outcome of rectovaginal fistula repair is poorly documented. We analyzed the outcome of rectovaginal fistula repairs based on preoperative sphincter status.",
"We identified... | All patients with rectovaginal fistula should undergo preoperative evaluation for occult sphincter defects by endoanal ultrasound or anal manometry or both procedures. Local tissues are inadequate for endorectal advancement flap repairs in patients with sphincter defects and a history of previous repairs. Patients with... | yes |
22351855 | Do minimally invasive/focused parathyroidectomy in patients with negative sestamibi scan results? | [
"To examine the feasibility of minimally invasive/focused parathyroidectomy in patients with primary hyperparathyroidism and negative results on preoperative sestamibi scanning.",
"Retrospective review.",
"Hospital.",
"A total of 452 patients with primary hyperparathyroidism underwent parathyroidectomy betwee... | Negative results on sestamibi scans should not be used as exclusion criteria for minimally invasive/focused parathyroidectomy in patients with primary hyperparathyroidism. In our study, 66 patients with negative results on preoperative scans were found to have a single adenoma and were surgically cured by minimally inv... | yes |
25562722 | Do pennogenyl saponins induce cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells? | [
"Pennogenyl saponins, the characterized components of Rhizoma Paridis, have been reported to have anticancer activity through induction of apoptosis or anti-metastasis in cultured cells or animal models. The aim of the study was to evaluate the anticancer properties of four pennogenyl saponins (PS1-PS4) on a panel ... | PS1 and PS2 had potent and selective anticancer activity to breast, liver and prostate cancer cells. Furthermore, the anticancer effects of PS1 and PS2 were associated with induction of apoptosis and blockage of cell cycle progression through multiple targets in HepG2 cells. These findings suggest that PS1 and PS2 can ... | yes |
11825344 | Does kefir consumption alter plasma lipid levels or cholesterol fractional synthesis rates relative to milk in hyperlipidemic men : a randomized controlled trial [ ISRCTN10820810 ]? | [
"Fermented milk products have been shown to affect serum cholesterol concentrations in humans. Kefir, a fermented milk product, has been traditionally consumed for its potential health benefits but has to date not been studied for its hypocholesterolemic properties.",
"Thirteen healthy mildly hypercholesterolemic... | Since kefir consumption did not result in lowered plasma lipid concentrations, the results of this study do not support consumption of kefir as a cholesterol-lowering agent. | no |
22930694 | Does effects of Olympic-style taekwondo kick on an instrumented head-form and resultant injury measures? | [
"The objective of this study was to assess the effect of taekwondo kicks and peak foot velocity (FVEL) on resultant head linear acceleration (RLA), head injury criterion (HIC15) and head velocity (HVEL).",
"Each subject (n=12) randomly performed five repetitions of the turning kick (TK), clench axe kick (CA), fro... | The TK is of concern because it is the most common technique and cause of concussion in taekwondo. Future studies should aim to understand rotational accelerations of the head. | yes |
17916019 | Do comparison of ophthalmic measurements obtained via high-frequency ultrasound imaging in four species of snakes? | [
"To measure the dimensions of the eyes of living snakes by use of high-frequency ultrasound imaging and correlate those measurements with age, length, and weight. Animals-14 clinically normal snakes.",
"Species, age, length, weight, and horizontal spectacle diameter were recorded, and each snake underwent physica... | Spectacle thickness, subspectacular space depth, and corneal thickness were similar among the species of snake examined and did not vary significantly with age, length, or weight. Measurements of these dimensions can potentially serve as baseline values to evaluate snakes of these species with a retained spectacle, sub... | yes |
11011333 | Does abciximab provide cost-effective survival advantage in high-volume interventional practice? | [
"Placebo-controlled randomized trials of platelet glycoprotein (GP) IIb/IIIa blockade during percutaneous coronary intervention have demonstrated efficacy of these agents for reducing the risk of periprocedural ischemic events. However, cost-effectiveness of this adjunctive pharmacotherapy has been scrutinized. Ext... | Abciximab provides a cost-effective survival advantage in high-volume interventional practice that compares favorably with currently accepted standards. Clinical and procedural demographics associated with increased cost-effectiveness included multivessel coronary intervention, stent deployment, recent (<1 week) myocar... | yes |
24060356 | Is small tumour size associated with new-onset chronic kidney disease after radical nephrectomy in patients with renal cell carcinoma? | [
"To investigate the impact of tumour size on postoperative glomerular filtration rate (GFR) in patients undergoing radical nephrectomy (RN) for renal cell carcinoma (RCC).",
"We retrospectively identified 1371 patients who underwent RN between 1995 and 2010. Serum creatinine levels were measured preoperatively, w... | Small tumour size is associated with CKD after RN. Partial nephrectomy should be considered in patients with tumour size 7cm or less. | yes |
27236154 | Do elevated circulating levels of IL-21 and IL-22 define a cytokine signature profile in type 2 autoimmune hepatitis patients? | [
" Background and aims. Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver in which the immunological mechanisms involved in tissue destruction and/or repair are still unclear. Different pro-inflammatory cytokines have been shown to play a determinant role in AIH pathogenesis. Here, we aim t... | We show for the first time, differential regulation of certain pro-inflammatory cytokines associated with disease progression and AIH type in Mexican patients. | yes |
27243904 | Does heavy Alcohol Use be Associated With Worse Retention in HIV Care? | [
"Poor retention in HIV care is associated with worse clinical outcomes and increased HIV transmission. We examined the relationship between self-reported alcohol use, a potentially modifiable behavior, and retention.",
"A total of 9694 people living with HIV from 7 participating US HIV clinical sites (the Centers... | Both heavy drinking and frequent binge drinking were associated with worse retention in HIV care. Increased identification and treatment of heavy and binge drinking in HIV clinical care settings may improve retention in HIV care, with downstream effects of improved clinical outcomes and decreased HIV transmission. | yes |
25801761 | Do plasma pro-endothelin-1 peptide concentrations rise in chronic kidney disease and following selective endothelin A receptor antagonism? | [
"Endothelin 1 (ET-1) contributes to chronic kidney disease (CKD) development and progression, and endothelin receptor antagonists are being investigated as a novel therapy for CKD. The proET-1 peptides, endothelin-like domain peptide (ELDP) and C-terminal pro-ET-1 (CT-proET-1), are both potential biomarkers of CKD ... | ELDP and CT-proET-1 increase in CKD and thus are potentially useful biomarkers of renal injury. Increases in response to endothelin A antagonism may reflect EDN1 upregulation, which may partly explain fluid retention with these agents. | yes |
24189507 | Does angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identify gestational diabetes mellitus? | [
"Gestational diabetes mellitus (GDM) is defined as glucose intolerance first recognized during pregnancy. Insertion/deletion (I/D) polymorphism of a 287 bp Alu repetitive sequence in intron 16 of the angiotensin-converting enzyme (ACE) gene has been widely investigated in Asian Indian populations with different eth... | ACE gene polymorphism was associated with GDM in Asian Indian pregnant women. | yes |
23082996 | Are aRF6 and GASP-1 post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D₂ receptors mediated by GRK and PKC in transfected cells? | [
"GPCRs undergo both homologous and heterologous regulatory processes in which receptor phosphorylation plays a critical role. The protein kinases responsible for each pathway are well established; however, other molecular details that characterize each pathway remain unclear. In this study, the molecular mechanisms... | GRK- and PKC-mediated internalizations of D₂ receptors occur through different intracellular trafficking pathways and mediate distinct functional roles. Distinct S/T residues within D₂ receptors and different sorting proteins are involved in the dissimilar regulation of D₂ receptors by GRK2 and PKC. | yes |
9627290 | Is spontaneous apoptosis of endometrial tissue impaired in women with endometriosis? | [
"To evaluate spontaneous apoptosis in single-cell suspensions of eutopic and ectopic endometrium from women with endometriosis and in eutopic endometrium from fertile controls without endometriosis.",
"Paired specimens of eutopic and ectopic endometrial tissue from patients with endometriosis and eutopic endometr... | The susceptibility of endometrial tissue to spontaneous apoptosis is significantly lower in women with endometriosis than in fertile controls. We suggest that decreased susceptibility of endometrial tissue to apoptosis contributes to the etiology or pathogenesis of endometriosis. | yes |
27075663 | Does salidroside alleviate oxidative stress in the liver with non- alcoholic steatohepatitis in rats? | [
"Nonalcoholic steatohepatitis (NASH) is characterized by fat accumulation in the hepatocyte, inflammation, liver cell injury, and varying degrees of fibrosis, and can lead to oxidative stress in liver. Here, we investigated whether Salidroside, a natural phenolic antioxidant product, can protect rat from liver inju... | The data presented here show that oral administration of Salidroside prevented liver injury in the NASH model, likely through exerting antioxidant actions to suppress oxidative stress and the free radical-generating CYP2E1 enzyme, Nox2 in liver. | yes |
8457090 | Do comparison of motor vehicle damage documentation in emergency medical services run reports compared with photographic documentation? | [
"To determine whether emergency medical services (EMS) run reports adequately document vehicle damage when compared with vehicle photographs by using a traffic accident scoring system.",
"A prospective study consisting of three phases: photographing motor vehicle collisions and collecting their respective EMS run... | Most EMS run reports do not document vehicle damage adequately. | yes |
9246705 | Does cure of Helicobacter pylori infection improve gastric acid secretion in patients with corpus gastritis? | [
"For more than 30 years it has been known that gastric acid secretion is inversely related to the extent and severity of corpal gastritis. We therefore evaluated the effect of cure of Helicobacter pylori infection on basal and pentagastrin-stimulated acid secretion.",
"Basal acid output (BAO) and maximal acid out... | Gastric acid secretion increased into the normal range after successful treatment of H. pylori infection, suggesting that gastric function can recover to normal or almost normal after cure of H. pylori infection. | yes |
25901496 | Does 17β-estradiol modify diabetic wound healing by decreasing matrix metalloproteinase activity ? | [
"Postmenopausal women are more susceptible to poor wound healing. This phenomenon can be reversed by estrogen replacement therapy in non-diabetic individuals. Postmenopausal women with type 2 diabetes are more susceptible to wound healing complications, potentially secondary to an estrogen deficiency. Few studie... | The mechanism appears to decrease MMP-2, MMP-13, and MMP-14 mediated tissue matrix destruction and increasing collagen content. . | yes |
16858288 | Is liver regeneration suppressed in small-for-size liver grafts after transplantation : involvement of c-Jun N-terminal kinase , cyclin D1 , and defective energy supply? | [
"Small-for-size liver grafts have decreased survival compared to full-size grafts. This study investigated mechanisms of suppression of liver regeneration in small-for-size grafts.",
"Rat liver explants were reduced in size to 50% and implanted into recipients of different body weights, resulting in graft weight/... | Liver regeneration is stimulated in half-size grafts but suppressed in quarter-size grafts. Defective liver regeneration in small grafts is associated with an inhibition of the c-Jun N-terminal kinase/c-Jun and CyD1 pathways and compromised energy production. | yes |
10912852 | Does sepsis after severe injury interrupt caspase-dependent processing of interleukin-18? | [
"Cysteine proteases (caspases) participate in the activation process of interleukin-18 (IL-18), a key cytokine for septic organ failure. This study evaluates the influence of caspase blockade on secretion of IL-18 into whole blood in patients with multiple injuries and in patients with severe sepsis.",
"Hepariniz... | Secretion of IL-18 into whole blood from healthy humans and trauma patients can be effectively controlled through blockade of caspase activity. In contrast, during sepsis, alternative mechanisms may regulate secretion of IL-18. | yes |
17207107 | Is apomorphine-induced growth hormone response attenuated by ethanol but not dextromethorphan? | [
"Misuse of alcohol drinking is a major health problem. Alcohol decreases spontaneous growth hormone (GH) secretion, but the mechanism is unclear. The aim of this study was to test whether administration of alcohol (study 1) or a N-methyl d-aspartate (NMDA) receptor antagonist (study 2) attenuates the GH response to... | A single intermediate alcohol dose markedly reduces GH response to dopaminergic stimulation. Although alcohol is thought to stimulate dopaminergic function in certain pathways, but not necessarily in the hypothalamus, our results are in line with the alcohol effect on baseline GH secretion. Growth hormone suppression a... | yes |
22715031 | Does resveratrol ameliorate diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice? | [
"This study investigated the effects of resveratrol (RV) on diabetes-related metabolic changes in a spontaneous model of type 2 diabetes, as well as activation of AMP-activated protein kinase (AMPK) and downstream targets.",
"C57BL/KsJ-db/db mice were fed a normal diet with RV (0.005% and 0.02%, w/w) or rosiglita... | RV potentiates improving glycemic control, glucose uptake, and dyslipidemia, as well as protecting against pancreatic β-cell failure in a spontaneous type 2 diabetes model. Dietary RV has potential as an antidiabetic agent via activation of AMPK and its downstream targets. | yes |
26019471 | Is infliximab superior to other biological agents for treatment of active ulcerative colitis : A meta-analysis? | [
"To compare the efficacy and safety of biological agents for the treatment of active ulcerative colitis (UC).",
"PubMed, MEDLINE, EMBASE and the Cochrane library were searched to screen relevant articles from January 1996 to August 2014. The mixed treatment comparison meta-analysis within a Bayesian framework was... | All biological agents were superior to placebo for UC treatment in both induction and maintenance phases with a similar safety profile, and infliximab had a better clinical effect than the other biological agents. | yes |
25593422 | Do effect of green tea on the second degree burn wounds in rats? | [
"Various studies indicate that the green tea has anti-inflammatory and anti-oxidative properties. Moreover, a few studies have been carried out that demonstrate beneficial effects of green tea on burned patients.",
"In this study, green tea, Vaseline, and silver sulfadiazine dressings were used as first-aid treat... | Green tea is effective on healing process of second degree burn wounds. | yes |
19546817 | Is pretreatment quality of life an independent prognostic factor for overall survival in patients with advanced stage non-small cell lung cancer? | [
"We conducted this pooled analysis to assess the prognostic value of pretreatment Quality of Life (QOL) assessments on overall survival (OS) in advanced non-small cell lung cancer (NSCLC).",
"Four hundred twenty patients with advanced NSCLC (stages IIIB with pleural effusion and IV) from six North Central Cancer ... | Pretreatment QOL measured by Uniscale is a significant and an independent prognostic factor for OS, and QOL should be routinely integrated as a stratification factor in advanced NSCLC trials. | yes |
25688670 | Does a novel mutation in IL36RN underpin childhood pustular dermatosis? | [
"Chronic pustular dermatoses are severe and debilitating autoinflammatory conditions that can have a monogenic basis. Their clinical features are, however, complex with considerable overlap. Null and missense mutations in the genes encoding interleukin (IL)-1 family (IL-1 and IL-36) anti-inflammatory receptor antag... | We describe a novel mutation which underpins the diagnosis of childhood pustular dermatosis. Molecular diagnostics can be used to aid the clinical diagnosis and potential treatment of autoinflammatory conditions. | yes |
15039637 | Do proinflammatory cytokines increase iron uptake into human monocytes and synovial fibroblasts from patients with rheumatoid arthritis? | [
"It has been hypothesized that iron is stored in the synovium of patients with rheumatoid arthritis which perpetuates inflamation by aiding the production of oxygen free radicals. Proinflammatory cytokines are produced by macrophages and lymphocytes present within synovium and by mononuclear cells of in synovial fl... | Proinflammatory cytokines produced in human rheumatoid arthritis synovium and synovial fluid may contribute to the accumulation of iron that occurs in rheumatoid arthritis synovium which may lead to damage to synovial fibroblasts, macrophages and lymphocytes. | yes |
21904137 | Are family history , surgery , and APC mutation risk factors for desmoid tumors in familial adenomatous polyposis : an international cohort study? | [
"Ability to identify patients with familial adenomatous polyposis who have a high risk of developing desmoid tumors may affect decisions in clinical practice.",
"Our aim was to assess several risk factors for desmoid tumor development in an international cohort of patients with familial adenomatous polyposis and ... | Selection bias may have occurred. | yes |
12372247 | Does the gibberellin pathway mediate KNOTTED1-type homeobox function in plants with different body plans? | [
"The shoot apical meristem (SAM) is an indeterminate structure that gives rise to the aerial parts of higher plants. Leaves arise from the differentiation of cells at the flanks of the SAM. Current evidence suggests that the precise regulation of KNOTTED1-like homeobox (KNOX) transcription factors is central to the... | We suggest that repression of GA activity by KNOX transcription factors is a key component of meristem function. Transfer of the KNOX/GA regulatory module from the meristem to the leaf may have contributed to the generation of the diverse leaf morphologies observed in higher plants. | yes |
27110261 | Is expression of MicroRNA-155 Downregulated in Peripheral Blood Mononuclear Cells of Chronic Hepatitis B Patients? | [
"Persistent hepatitis B virus (HBV) infection is sustained by inadequate immune responses, either natural or acquired. Recent studies have suggested that immune responses to viral infection may be affected by microRNA (miR)-155, via its involvement in immune cell differentiation and maturation. However, little is k... | The miR-155 appeared to be suppressed during HBV infection. The significantly higher miR-155 levels in ALT-elevated patients infected with HBV suggest that miR-155 levels in PBMCs correlate with the immune state of patients with chronic HBV infection. | yes |
10728442 | Is synovial fluid lymphocyte proliferation in response to crude microbial antigens useful as a diagnostic test to specifically indicate a bacterial cause of arthritis? | [
"To determine the role of lymphocyte proliferation assay of synovial fluid mononuclear cells (SFMC) with whole fraction bacteria in the diagnosis of reactive arthritis (ReA) or arthritis of unknown origin.",
"We stimulated SFMC of 52 unselected patients who consecutively presented in our rheumatology outpatient c... | Our findings show that a lymphocyte proliferation assay with SFMC with whole fraction bacteria is not an adequate diagnostic tool to confirm bacterial involvement in inflammatory arthritis. | no |
26710841 | Is high body-mass index associated with worse clinicopathological characteristics in predominantly obese breast cancer patients? | [
"Breast cancer (BC) is the most common cancer among women. A high body-mass index (BMI) is related to increased incidence of BC with poorer prognosis.",
"The aim of the study was to evaluate the association in patients with BC between BMI at the time of diagnosis and biological characteristics, according to the m... | There are many conflicting results in literature on this relationship. The results of this study showed that a high BMI is not associated with worse clinicopathological characteristics in a predominantly obese population. In current medical oncology practice, BC should be evaluated on an individual patient basis and th... | no |
12065913 | Does theophylline inhibit NF-kappaB activation in human peripheral blood mononuclear cells? | [
"Theophylline not only dilates the bronchi, but also modulates the production of proinflammatory cytokines and inhibits inflammation. Theophylline exerts an antiinflammatory effect on allergic inflammation through inhibition of NF-kappaB activation in mast cells. However, the action of theophylline on monocytes/mac... | These findings are consistent with the idea that theophylline suppresses the production of proinflammatory cytokines via inhibition of NF-kappaB activation through preservation of the IkappaBalpha protein in monocytes/macrophages and T cells. | yes |
19881148 | Is a386G polymorphism of the DAZL gene associated with idiopathic male infertility in North India? | [
"Male infertility is a multifactorial disorder which affects approximately 10% of couples at childbearing age with substantial clinical and social impact. Genetic variation and environmental factors contribute to susceptibility to spermatogenic impairment in humans. The A386G (T54A) polymorphism of the autosomal ge... | As in the report from Italy and South India, our results illustrate the rarity of this mutation. Apparently, this mutation is of recent origin and/or has poor selective value. Its preponderance in infertile patients from Taiwan (all heterozygotes) suggests a founder effect and also that its low selective value could be... | no |
22040415 | Does 1,5-dicaffeoylquinic acid protect primary neurons from amyloid β 1-42-induced apoptosis via PI3K/Akt signaling pathway? | [
"Recently, 1,5-dicaffeoylquinic acid (1,5-DQA), a caffeoylquinic acid derivative isolated from Aster scaber, was found to have neuroprotective effects. However, the protective mechanisms of 1,5-DQA have not yet been clearly identified. The purpose of this study was to explore the protective mechanisms of 1,5-DQA on... | These results suggest that 1,5-DQA prevents Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax. | yes |
25071104 | Does tumor stage after neoadjuvant chemotherapy determine survival after surgery for adenocarcinoma of the esophagus and esophagogastric junction? | [
"Neoadjuvant chemotherapy is established in the management of most resectable esophageal and esophagogastric junction adenocarcinomas. However, assessing the downstaging effects of chemotherapy and predicting response to treatment remain challenging, and the relative importance of tumor stage before and after chemo... | The stage of esophageal or esophagogastric junction adenocarcinoma after neoadjuvant chemotherapy determines prognosis rather than the clinical stage before neoadjuvant chemotherapy, indicating the importance of focusing on postchemotherapy staging to more accurately predict outcome and eligibility for surgery. Patient... | yes |
26110043 | Is insulin resistance associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans? | [
"Mitochondrial alterations have been observed in subjects with metabolic disorders such as obesity and diabetes. Studies on animal models and cell cultures suggest aberrant glucose and lipid levels, and impaired insulin signaling might lead to mitochondrial changes. However, the molecular mechanism underlying mitoc... | The reduction of mtDNAn in obese human subjects is associated with insulin resistance and may arise from increased D-loop methylation, suggesting an insulin signaling-epigenetic-genetic axis in mitochondrial regulation. | yes |
27785750 | Do gly972Arg of IRS-1 and Lys121Gln of PC-1 polymorphisms act in opposite way in polycystic ovary syndrome? | [
"Polycystic ovary syndrome (PCOS) was associated with a number of polymorphisms of genes involved in insulin signaling. So far, they have been studied separately. The aim of this study was to verify the impact of the coexistence of two polymorphisms of insulin signaling.",
"One hundred consecutive PCOS women (dia... | Genetic variations in insulin signaling contribute to the extent and the variability of metabolic and hormonal derangement. | yes |
21696925 | Is actigraphic daytime activity reduced in patients with cognitive impairment and apathy? | [
"Apathy is a neuropsychiatric symptom in mild cognitive impairment (MCI) and dementia. This study examines correlations between Apathy Evaluation Scale (AES) ratings and actigraphic measures of daytime activity. The aim of this study is to determine the value of ambulatory actigraphy in the assessment of locomotor ... | Ambulatory actigraphy is a promising method to evaluate self-initiated action as a correlate of apathy in patients with cognitive impairment. | yes |
22306274 | Does interpretation of point-of-care INR result in patients treated with dabigatran? | [
"Point-of-care devices for measurement of the international normalized ratio (INR) are commonly used to monitor therapy and maintain therapeutic levels of anticoagulation in patients treated with vitamin K antagonists. Dabigatran, a new oral, reversible direct thrombin inhibitor approved for stroke prevention in pa... | INR levels in patients taking dabigatran are substantially higher using a Hemochron Jr. point-of-care device compared with laboratory values. We discourage the use of these devices specifically, as well as the use of the INR in general, for measuring the anticoagulant effect of dabigatran. | yes |
23840305 | Does activation of GPER induce Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation? | [
"Vascular pathology and dysfunction are direct life-threatening outcomes resulting from atherosclerosis or vascular injury, which are primarily attributed to contractile smooth muscle cells (SMCs) dedifferentiation and proliferation by re-entering cell cycle. Increasing evidence suggests potent protective effects o... | GPER activation inhibits CASMC proliferation by suppressing cell cycle progression via inhibition of ERK1/2 and Akt phosphorylation. GPER may constitute a novel mechanism to suppress intimal migration and/or synthetic phenotype of VSMC. | yes |
21492407 | Does inhibition of interleukin-6 attenuate erectile dysfunction in a rat model of nerve-sparing radical prostatectomy? | [
"The precise mechanisms underlying erectile dysfunction (ED) occurring after cavernous nerve (CN)-sparing surgery remain to be determined. Aim. To evaluate the expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) after CN injury, and the effect of inhibiting IL-6 bioactivity on nerve injury-related ED.",
... | Expression levels of IL-6 in the MPG were increased in the acute phase following CN injury. Inhibition of IL-6 bioactivity attenuated ED following CN dissection. Thus, the suppression of excess inflammatory responses in the acute phase may lead to improvements in ED occurring after nerve-sparing radical prostatectomy. | yes |
21356044 | Is sphingosine-1 phosphate receptor ( S1p1 ) , a critical receptor controlling human lymphocyte trafficking , expressed in hen and human ovaries and ovarian tumors? | [
"Sphingosine-1 receptor 1 (S1P1) plays a major role in regulating lymphocyte egress from peripheral lymph tissue. Lymphocyte trafficking is potentially a critical response to tumors and to tumor vaccines. Also, the receptor has been shown to influence metastasis. However, there is little information on its expressi... | The results show that S1P1 is expressed in the hen and human ovary as well as in ovarian tumors. These findings support the use of the hen in further studies of the role of S1P1 in metastasis and immune cell trafficking in ovarian tumor development. | yes |
20148651 | Does lovastatin inhibit the thrombin-induced loss of barrier integrity in bovine corneal endothelium? | [
"Increased actomyosin contraction of the dense band of actin cytoskeleton at the apical junctional complex (perijunctional actomyosin ring, PAMR) breaks down the barrier integrity of corneal endothelium. This study has investigated the efficacy of statins, which inhibit activation of RhoA, in opposing the thrombin-... | Lovastatin attenuates RhoA activation in the corneal endothelium presumably by reducing its isoprenylation. This underlies the suppression of the thrombin-induced loss in barrier integrity of the corneal endothelium. | yes |
22253320 | Is socio-economic status associated with epigenetic differences in the pSoBid cohort? | [
"Epigenetic programming and epigenetic mechanisms driven by environmental factors are thought to play an important role in human health and ageing. Global DNA methylation has been postulated as an epigenetic marker for epidemiological studies as it is reflective of changes in gene expression linked to disease. How ... | This study has indicated an association between epigenetic status and socio-economic status (SES). This relationship has direct implications for population health and is reflected in further associations between global DNA methylation content and emerging biomarkers of CVD. | yes |
10770531 | Is lack of mother-to-child HIV-1 transmission associated with elevated serum levels of 90 K immune modulatory protein? | [
"90 K is a secreted human serum glycoprotein with immune modulatory activity.",
"Serum 90 K levels were determined by an enzyme-linked immunosorbent assay in 19 HIV-1-infected mothers at the time of delivery, in their new-borns (11 HIV-1 infected and eight uninfected), in 26 HIV-1-uninfected mothers and in 86 new... | These results suggest that high 90 K protein serum levels in HIV-1-infected mothers and their new-borns are associated with lack of mother-to-child HIV-1 transmission. | yes |
26488833 | Do feasibility of a Text Messaging Intervention to Promote Self-Management for Patients Prescribed Oral Anticancer Agents? | [
"To determine proof of concept of a mobile health (mHealth) intervention delivering text messages (texts) to self-manage among patients prescribed oral anticancer agents (OAs) and to examine preliminary efficacy on symptoms and medication adherence.",
"A longitudinal randomized, controlled trial.",
"Two communi... | Proof of concept and preliminary efficacy of an mHealth intervention using texts to promote self-management for patients prescribed OAs was demonstrated. Patients had high satisfaction with the texts, and adherence and symptoms improved after the intervention. | yes |
26203225 | Is apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers lower in water enriched in oxygen by electrolysis than injection? | [
"It has been suggested that oxygen (O2) diffusion could be favored in water enriched in O2 by a new electrolytic process because of O2 trapping in water superstructures (clathrates), which could reduce the local pressure/content relationships for O2 and facilitate O2 diffusion along PO2 gradients.",
"Mitochondria... | In this experiment, a higher affinity of the mitochondria for O2 was observed in water enriched in O2 by electrolysis than by injection. This observation is consistent with the hypothesis that O2 diffusion can be facilitated in water enriched in O2 by the electrolytic process. | yes |
23489766 | Are preoperative lymphoscintigraphy and tumor histologic grade associated with surgical detection of the sentinel lymph node? | [
"To study which variables involved in the process of selective sentinel node biopsy (SSNB) influence the intraoperative detection of the sentinel lymph node.",
"This was a prospective cross-sectional study in 210 patients (mean age, 54 years) diagnosed with breast cancer who underwent SSNB. We recorded clinical, ... | The probability of not detecting the sentinel lymph node during the surgical intervention is higher in patients with high histologic grade tumors or in patients in whom preoperative lymphoscintigraphy failed to detect the sentinel node. | yes |
20644730 | Are telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster , and the DECORIN gene imprinted in human trophoblast stem cells? | [
"Genomic imprinting of the largest known cluster, the Kcnq1/KCNQ1 domain on mChr7/hChr11, displays significant differences between mouse and man. Of the fourteen transcripts in this cluster, imprinting of six is ubiquitous in mice and humans, however, imprinted expression of the other eight transcripts is only foun... | The question of placental specific imprinting in the human has not been answered fully. Using a model of human trophoblast very early in gestation we show a lack of imprinting of two telomeric genes in the KCNQ1 region and of DCN, whose imprinted expression is placental specific in mice, providing further evidence to s... | no |
23903236 | Does turmeric curcumin inhibit entry of all hepatitis C virus genotypes into human liver cells? | [
"Hepatitis C virus (HCV) infection causes severe liver disease and affects more than 160 million individuals worldwide. People undergoing liver organ transplantation face universal re-infection of the graft. Therefore, affordable antiviral strategies targeting the early stages of infection are urgently needed to pr... | Turmeric curcumin inhibits HCV entry independently of the genotype and in primary human hepatocytes by affecting membrane fluidity thereby impairing virus binding and fusion. | yes |
23379811 | Are higher energy prices associated with diminished resources , performance and safety in Australian ambulance systems? | [
"To evaluate the impact of changing energy prices on Australian ambulance systems.",
"Generalised estimating equations were used to analyse contemporaneous and lagged relationships between changes in energy prices and ambulance system performance measures in all Australian State/Territory ambulance systems for th... | Changes in energy prices are associated with changes in Australian ambulance systems' resource, performance and safety characteristics in ways that could affect both patients and personnel. Further research is needed to explore the mechanisms of, and strategies for mitigating, these impacts. The impacts of energy price... | yes |
19955748 | Does shock wave therapy effectively attenuate inflammation in rat carotid artery following endothelial denudation by balloon catheter? | [
"This study investigates the effectiveness of extracorporeal shock wave (ECSW) in ameliorating inflammatory mediator expression and neointimal formation in a rat model of vascular injury.",
"Male Sprague-Dawley rats with left carotid artery (LCA) injury induced by balloon dilatation (BD; group 1) were compared wi... | ECSW markedly attenuates inflammatory responses, proliferation of neointima and smooth muscle cells in a rat vascular injury model. | yes |
26423718 | Are cDH13 Polymorphisms Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass? | [
"Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral fat accumulation increases, adiponectin levels decrease; therefore, adiponectin provides a link between visceral fat accumulation and metabolic disorders. Genome-wide association studies (GWASs) have identified genetic vari... | These results suggested that CDH13 SNPs cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits. | yes |
22005037 | Does magnetic resonance angiography-diffusion mismatch reflect diffusion-perfusion mismatch in patients with hyperacute cerebral infarction? | [
"We evaluated whether clinical-diffusion mismatch (CDM) or magnetic resonance angiography (MRA)-diffusion mismatch (MDM) is useful in detecting diffusion-perfusion mismatch (DPM) in hyperacute cerebral infarction within 3 hours after stroke onset.",
"Among patients with cerebral infarction who arrived within 3 ho... | In hyperacute cerebral infarction within 3 hours after onset, MDM, as compared with CDM, was able to detect DPM with higher sensitivity and specificity. This suggests that MDM is more reflective of DPM. | yes |
11347740 | Is concordance for type 1 diabetes in identical twins affected by insulin genotype? | [
"Monozygotic twins are usually discordant (only one twin affected) for type 1 diabetes. Discordance for disease between such twins implies a role for nongenetically determined factors but could also be influenced by a decreased load of diabetes susceptibility genes. The aim of this study was to determine whether tw... | We conclude that the possession of the high-risk Hph I insulin genotype increases the likelihood of identical twins being concordant for type 1 diabetes and that the "load" of both major histocompatibility complex (MHC) and non-MHC susceptibility genes has an impact on the disease penetrance of type 1 diabetes. | yes |
25062727 | Are low serum concentrations of alpha-tocopherol associated with increased risk of hip fracture . A NOREPOS study? | [
"We investigated the risk of hip fracture according to circulating alpha-tocopherol, a plant-derived substance with antioxidant properties, in community-dwelling older Norwegians. We found a linear increasing risk of hip fracture with lower serum alpha-tocopherol concentrations, with a 51% higher risk in the lowest... | Low serum concentrations of α-tocopherol were associated with increased risk of hip fracture in older Norwegians. | yes |
8203977 | Is insulin regulation of hepatic glucose transporter protein impaired in chronic pancreatitis? | [
"The effect of chronic pancreatitis and insulin on the expression of the hepatic facilitative glucose transporter protein (GLUT-2) was determined in rats.",
"Chronic pancreatitis is associated with diabetes mellitus or impaired glucose tolerance. Suppression of hepatic glucose production (HGP) by insulin is impai... | Insulin suppresses glucagon-stimulated HGP in normal and sham-operated rats, and this reduction in HGP is associated with a decrease in the membrane-bound quantity of GLUT-2. In chronic pancreatitis, insulin suppression of HGP is absent, and this is accompanied by an increase in GLUT-2 in the hepatocyte membrane. The a... | yes |
18536968 | Do most patients with colorectal tumors at young age visit a cancer genetics clinic? | [
"This study examined the referral process for genetic counseling at a cancer genetics clinic in patients with colorectal cancer and to search for determinants of variation in this referral process.",
"Patients who were recently diagnosed with colorectal cancer at a young age or multiple cancers associated with Ly... | The referral process is not optimally carried out. To deliver optimal care for patients suspected of hereditary colorectal cancer, this process must be improved with interventions focusing on patient referral by surgeons and raising awareness in nonteaching hospitals. | no |
19346978 | Is gross efficiency during rowing affected by stroke rate? | [
"It has been suggested that the optimal stroke rate in rowing is partly determined by the stroke-rate dependence of internal power losses. This should be reflected in a stroke-rate dependency of gross efficiency (e(gross)). The purpose of this study was to investigate if e(gross) is affected by stroke rate. A secon... | This study shows that within the range of stroke rates applied in competitive rowing, internal power losses are unrelated to rowing cycle frequency. | no |
15055571 | Does evaluation of a fall prevention program for independent elderly? | [
"To evaluate the effectiveness of an older adult falls-prevention program and describe compliance with the program.",
"The No More Falls! program was evaluated by comparing outcomes of program participants and nonparticipants from the same health care system and by comparing outcomes in pre- and postintervention ... | These findings suggest that the No More Falls! program was successful in reducing falls among older adults. | yes |
9048239 | Does the addition of norethindrone acetate to leuprolide acetate for ovarian suppression have no adverse effect on ovarian stimulation? | [
"Our goal was to determine if the addition of norethindrone acetate (NETA) to leuprolide acetate (LA) has an adverse effect on controlled ovarian stimulation (COH) during in vitro fertilization (IVF).",
"Forty-one consecutive patients undergoing COH and IVF were divided into two groups and evaluated. Group 1 cons... | The addition of NETA does not attenuate COH in women undergoing IVF. | yes |
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