id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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21858849 | Is higher serum testosterone associated with increased risk of advanced hepatitis C-related liver disease in males? | [
"Males have strikingly increased risk of advanced liver disease. However, the association between testosterone and risk of hepatitis C virus (HCV)-related advanced liver disease is unknown. We performed a cross-sectional study in male veterans with chronic HCV. Blood samples were obtained to measure total serum tes... | Total serum testosterone is associated with an increased risk of both advanced hepatic fibrosis and advanced hepatic inflammatory activity in HCV-infected men. Testosterone may be important in the pathogenesis of HCV-related advanced liver disease in males. | yes |
18547786 | Is intake of water from foods , but not water from beverages , related to lower body mass index and waist circumference in free-living humans [ corrected ]? | [
"Experimental trials using test meals suggest that water promotes satiety and decreases subsequent intake, thus possibly working to prevent obesity, when it is consumed as an integral component of a food, but not when consumed alone or alongside a food. We examined the associations of intake of water from beverages... | Intake of water from foods, but not water from beverages, was independently associated with lower BMI and waist circumference in free-living humans consuming self-selected diets. | yes |
17667771 | Does current steering create additional pitch percepts in adult cochlear implant recipients? | [
"The number of spectral channels is the number of discriminable pitches heard as current is delivered to distinct locations along the cochlea. This study aimed to determine whether cochlear implant users could hear additional spectral channels using current \"steering.\" Current steering involves the simultaneous d... | These results indicate that additional pitch percepts can be created using current steering. | yes |
15711095 | Is c-Jun N-terminal kinase involved in mercuric ions-mediated interleukin-4 secretion in mast cells? | [
"Interleukin (IL)-4 plays a prominent role in immune response. Mercuric compounds upregulate IL-4 expression in animal tissues, and this upregulation plays a role in mercuric-mediated immunomodulation. Mercuric ions-mediated IL-4 expression was observed in vitro in T lymphocytes and mast cells. In the present study... | These observations are consistent with the hypothesis that JNK is one of the signaling proteins mediating the effect of Hg(2+) on IL-4 expression in mast cells and is engaged in environmentally mediated immunomodulation. | yes |
24934585 | Is rate of contralateral prophylactic mastectomy influenced by preoperative MRI recommendations? | [
"Women with breast cancer increasingly undergo contralateral prophylactic mastectomy (CPM). We evaluated the relationship between preoperative magnetic resonance imaging (MRI) findings and CPM. Other clinicopathologic variables associated with CPM choice and the pathology found in the contralateral breast are also ... | Abnormal findings in the contralateral breast on preoperative MRI, as well as young age, reconstruction and HER2-positive status correlated with CPM choice in this cohort. Occult malignancy was rare. | yes |
11821083 | Does overexpression of theca-cell messenger RNA in polycystic ovary syndrome correlate with polymorphisms in the cholesterol side-chain cleavage and 17alpha-hydroxylase/C ( 17-20 ) lyase promoters? | [
"To determine whether overexpression of CYP17 or CYP11A messenger (m)RNA in theca cells from polycystic ovaries is related to polymorphic regions in the gene promoters that may increase transcription.",
"Case-control study.",
"Research institute.",
"Fifty-one women with PCOS and 280 regularly cycling controls... | Overexpression of CYP17 and CYP11A mRNA in theca cells from polycystic ovaries is explained by polymorphic differences in the gene promoters. | no |
9372731 | Do dehydration injury as a possible cause of visual field defect after pars plana vitrectomy for macular hole? | [
"To present the hypothesis that a visual field defect after pars plana vitrectomy for macular hole may be caused by dehydration injury to the nerve fiber layer during the fluid-air exchange.",
"In a consecutive nonrandomized series of 45 operations on 35 eyes of 34 patients with full-thickness macular hole, the s... | Dehydration injury of the nerve fiber layer during the fluid-air exchange should be considered as a possible cause of visual field defect after pars plana vitrectomy for macular hole. | yes |
20488721 | Do lung cancer resection rates have increased significantly in females during a 15-year period? | [
"The aim was to carry out a comparative study of lung cancer incidence and resection rates following the introduction of positron emission tomography-computed tomography (PET-CT) and the reorganisation of Cancer Services in Northern Ireland.",
"Data were retrieved from the Regional Thoracic Service Database and N... | The resection rate is currently higher in females than males, and has significantly increased during the study period. The incidence in female lung cancer has risen but it is still below male incidence rates. It seems unlikely that one single factor has brought about this increase. With better education among medical p... | yes |
25008236 | Does ipilimumab augment antitumor activity of bispecific antibody-armed T cells? | [
"Ipilimumab is an antagonistic monoclonal antibody against cytotoxic T-lymphocyte antigen-4 (CTLA-4) that enhances antitumor immunity by inhibiting immunosuppressive activity of regulatory T cells (Treg). In this study, we investigated whether inhibiting Treg activity with ipilimumab during ex vivo T cell expansion... | Expansion of ATC in the presence of ipilimumab significantly improves not only the T cell proliferation but it also enhances cytokine secretion and the specific cytotoxicity of T cells armed with bispecific antibodies. | yes |
17803842 | Is post-carotid endarterectomy neurocognitive decline associated with cerebral blood flow asymmetry on post-operative magnetic resonance perfusion brain scans? | [
"Up to 25% of patients experience subtle declines in post-operative neurocognitive function following, otherwise uncomplicated, carotid endarterectomy (CEA). We sought to determine if post-CEA neurocognitive deficits are associated with cerebral blood flow (CBF) abnormalities on post-operative MR perfusion brain sc... | Post-CEA neurocognitive dysfunction is significantly associated with post-operative CBF asymmetry. These results support the hypothesis that post-CEA cognitive impairment is caused by cerebral hemodynamic changes. Further work exploring the relationship between CBF and post-CEA cognitive dysfunction is needed. | yes |
27468901 | Does sclerostin play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus? | [
"In contrast to previously reported elevations in serum sclerostin levels in diabetic patients, the present study shows that the impaired bone microarchitecture and cellular turnover associated with type 2 diabetes mellitus (T2DM)-like conditions in ZDF rats are not correlated with changes in serum and bone scleros... | T2DM results in impaired skeletal architecture through altered remodelling pathways, but despite altered serum levels, it does not appear that sclerostin contributes to the deleterious effect of T2DM in rat bone. | no |
19399936 | Is high level of ezrin expression in colorectal cancer tissues closely related to tumor malignancy? | [
"To investigate the ezrin expression in normal colorectal mucosa and colorectal cancer tissues, and study the correlation between ezrin expression in colorectal cancer tissues and tumor invasion and metastasis.",
"Eighty paraffin-embedded cancer tissue samples were selected from primary colorectal adenocarcinoma.... | Ezrin expression is obviously higher in colorectal cancer tissues than in normal colorectal mucosa tissues, and the high level of ezrin expression is closely related to the colorectal cancer invasion and metastasis process. | yes |
16462473 | Does outcome of surgical clipping of unruptured aneurysms as it compare with a 10-year nonclipping survival period? | [
"Recent studies on the natural history of unruptured intracranial aneurysms dictate that we reevaluate the risks and benefits of surgical intervention as it compares with the natural course. We analyzed the outcome of surgical clipping of a patient cohort with unruptured aneurysms as it compares with a 10 year nonc... | Studies on natural history of unruptured intracranial aneurysms suggest 10 year cumulative bleeding-related mortality and severe morbidity of no less than 7.5%. In our study, surgical clipping resulted in an 0.8% rate of mortality and 3.4% permanent morbidity. This suggests that surgical clipping has the potential of a... | yes |
23568436 | Does recurrent and founder mutations in the Netherlands-Phospholamban p.Arg14del mutation cause arrhythmogenic cardiomyopathy? | [
"Recently, we showed that the c.40_42delAGA (p.Arg14del) mutation in the phospholamban (PLN) gene can be identified in 10-15 % of Dutch patients with dilated cardiomyopathy or arrhythmogenic cardiomyopathy. The arrhythmogenic burden of the p.Arg14del mutation was illustrated by the high rate of appropriate ICD disc... | The p.Arg14del mutation in the PLN gene is the most frequently identified mutation in Dutch cardiomyopathy patients. The mutation that arose 575-825 years ago is likely to have originated from the eastern part of the province of Friesland and is highly prevalent in the general population in the northern part of the Net... | yes |
21933551 | Is laparoscopic partial nephrectomy for T1a renal tumors safe and feasible? | [
"Some patients with exophytic renal masses less than 4 cm and suboptimal renal function, or a solitary kidney and bilateral renal tumors are considered for laparoscopic partial nephrectomy (LPN), which is feasible for early-stage renal tumors, although it is still considered technically difficult and time consuming... | LPN for pT(1) stage renal tumor was safe and feasible. Hem-o-lok instead of traditional ligature to clamp the suture when sewing the renal wound could shorten the warm ischemia time. | yes |
20407432 | Is kCNN4 gene variant associated with ileal Crohn 's Disease in the Australian and New Zealand population? | [
"Crohn's disease (CD; MIM 266600) is one of the most common forms of inflammatory bowel disease (IBD), and represents a significant burden to health care in developed countries. Our aim was to determine whether a gene in the IBD linkage region on chromosome 19q13, with a role in Paneth cell secretion and T-cell act... | Our data implicate the role of KCNN4 in ileal CD. The dual roles of KCNN4 in Paneth cell secretion and T-cell activation and also its nature as a potassium channel make it an important and practical therapeutic target. | yes |
22396758 | Do syndecans reside in sphingomyelin-enriched low-density fractions of the plasma membrane isolated from a parathyroid cell line? | [
"Heparan sulfate proteoglycans (HSPGs) are one of the basic constituents of plasma membranes. Specific molecular interactions between HSPGs and a number of extracellular ligands have been reported. Mechanisms involved in controlling the localization and abundance of HSPG on specific domains on the cell surface, suc... | Both syndecan-1 and syndecan-4 have been found to specifically associate with membrane rafts and their association seemed independent of intact HS chains. Membrane rafts in which HSPGs reside were also enriched with sphingomyelin, suggesting their possible involvement in FGF signaling. Further studies, involving proteo... | yes |
23557734 | Do aβ-induced senescent retinal pigment epithelial cells create a proinflammatory microenvironment in AMD? | [
"Chronic inflammation is implicated in the pathogenesis of AMD. The source of chronic inflammation is often attributed to the progressive activation of immune cells over time. However, recent studies have shown that senescent cells can alter tissue microenvironment via secretion of growth factors, proteases, and in... | The altered secretory phenotype of senescent RPE cells may contribute to age-related inflammation in AMD. Chinese Abstract. | yes |
19606165 | Does p38 mitogen-activated protein kinase protect human retinal pigment epithelial cells exposed to oxidative stress? | [
"To investigate the role of p38 mitogen-activated protein kinase (MAPK) in human retinal pigment epithelial (RPE) cells exposed to acute oxidative stress.",
"Experimental study.",
"Oxidative stress was induced by the chemical oxidant tert-butyl hydroperoxide (t-BOOH) in the human RPE cell line ARPE-19. Cell via... | Under the conditions tested, activation of p38 MAPK protects ARPE-19 cells against oxidant-induced death. Because RPE cells play a key role in retinal homeostasis, this finding may have important implications for retinal disease. | yes |
15573035 | Does pressure immobilization delays mortality and increase intracompartmental pressure after artificial intramuscular rattlesnake envenomation in a porcine model? | [
"We determine the effect of pressure immobilization on mortality and intracompartmental pressure after artificial intramuscular Crotalus atrox envenomation in a porcine model.",
"We prospectively studied 20 pigs using a randomized, controlled design. After anesthesia, C atrox venom (20 mg/kg) was injected with a ... | Compared with control animals without treatment, the pressure immobilization group had longer survival, less swelling, and higher intracompartmental pressures after artificial, intramuscular C atrox envenomation in our porcine model. | yes |
19885419 | Does maximizing tissue response in selected subjects with anterior open bite? | [
"Open bites are challenging malocclusions with a multifactorial etiology, varying clinical severity, and questionable stability. The aim of this article is to describe a method for maximizing tissue response in the treatment of selected subjects with anterior open bites.",
"Twelve subjects with an anterior open b... | It is possible to close anterior open bites rapidly with significant improvement in smile esthetics in a selected group of anterior open-bite subjects. | yes |
16998358 | Does an acute care surgery model improve outcomes in patients with appendicitis? | [
"To compare outcomes of appendectomy in an Acute Care Surgery (ACS) model to that of a traditional home-call attending surgeon model.",
"Acute care surgery (ACS, a combination of trauma surgery, emergency surgery, and surgical critical care) has been proposed as a practice model for the future of general surgery.... | In patients with acute appendicitis, the presence of an in-house acute care surgeon significantly decreased the time to operation, rupture rate, complication rate, and hospital length of stay. The ACS model appears to improve outcomes of acute appendicitis compared with a TRAD home-call model. This study supports the e... | yes |
12973117 | Does administration of dendritic cells transduced with antisense oligodeoxyribonucleotides targeting CD80 or CD86 prolong allograft survival? | [
"The expression of costimulatory molecules on antigen-presenting cells is crucial in determining T-cell immune responses. We examined the effects of transduction with high-affinity antisense oligodeoxyribonucleotides (ODNs) designed to target the mRNA of CD80 or CD86 on the phenotype and function of dendritic cells... | Transduction with antisense ODN targeting CD80 or CD86mRNA is a feasible and effective approach to modify DCs that renders them tolerogenic by inducing T-cell hyporesponsiveness and apoptosis. This may lead to the development of new therapeutic strategies in transplantation. | yes |
25371888 | Does mitochondrial Channel Opener Diazoxide attenuate Hypoxia-Induced sFlt-1 Release in Human Choriocarcinoma Cells? | [
"To examine the effect of diazoxide on hypoxia-induced soluble fms-like tyrosin kinase-1 (sFlt-1) release in JEG-3 choriocarcinoma cells.",
"Cells were cultured under normoxia (20% O2) or hypoxia (1% O2), and expression of sFlt-1 mRNA and protein release was determined by quantitative real-time reverse-transcript... | These results, taken together, strongly suggest that up-regulation of the HO-1 expression is the crucial mechanism responsible for the diazoxide-induced inhibition of the sFlt-1 release and ROS production under hypoxia. | yes |
18442200 | Are t cell responses to hepatitis B surface antigen detectable in non-vaccinated individuals? | [
"To evaluate, whether humoral hepatitis-B-vaccine non-responders also fail to mount a T cell response and to compare these results to normal vaccinees.",
"Fourty-seven health care employees were enrolled in this study including all available non-responders (n = 13) with an anti-HBsAg titer < 10 kU/L and all avail... | Our data suggest that there is no general immune deficiency in non-/low-responders. Thus, we hypothesize that the induction of anti-HBsAg responses by vaccination is significantly dependent on the pre-existing T cell repertoire against the specific antigen rather than the presence of a general T cell defect. | yes |
23906902 | Does tumor necrosis factor-308 polymorphism increase the embryo implantation rate in women undergoing in vitro fertilization? | [
"Do TNF-308 and -238 polymorphisms impact the embryo implantation rate after in vitro fertilization (IVF) in women without female infertility factor?"
] | The presence of the TNF-308A allele is associated with high implantation and multiple pregnancy rates in women without known infertility factors after ovarian hyperstimulation with exogenous FSH. | yes |
19422839 | Does cariporide ( HOE642 ) attenuate lactic acidosis induced pulmonary vein arrhythmogenesis? | [
"Lactic acidosis causes atrial fibrillation (AF), and pulmonary veins (PVs) are the most important focus for the generation of AF. Cariporide (HOE642), a Na(+)/H(+) blocker, can prevent atrial tachycardia-induced electrical remodeling. The purpose of this study was to investigate whether cariporide can prevent lact... | Lactic acidosis has significant arrhythmogenic effects on PVs, which may be attenuated by Na(+)/H(+) blockers. | yes |
25222776 | Do mortality profile of patients with traumatic spinal injuries at a level I trauma care centre in India? | [
"There is no national spinal trauma registry available in India at present and the research on epidemiology of these injuries is also very limited. The purpose of this study was to describe the mortality profile of patients with spinal injuries brought to a level I trauma centre in India, and to understand the pred... | Our data suggest that there is an urgent need to take steps to prevent major injuries, strengthen the pre-hospital care, transportation network, treatment in specialized trauma care units and to improve injury surveillance and the quality of data collected which can guide prevention efforts to avoid loss of young activ... | yes |
20691056 | Does dual mobility cup reduce dislocation rate after arthroplasty for femoral neck fracture? | [
"Hip dislocation after arthroplasty for femoral neck fractures remains a serious complication. The aim of our study was to investigate the dislocation rate in acute femoral neck fracture patients operated with a posterior approach with cemented conventional or dual articulation acetabular components.",
"We compar... | We conclude that the use of a cemented dual articulation acetabular component significantly reduces the dislocation rates in femoral neck fracture patients operated via posterior approach. | yes |
12411665 | Does transient focal ischemia increase endothelial nitric oxide synthase in cerebral blood vessels? | [
"Production of NO by endothelial NO synthase (eNOS) plays a protective role in cerebral ischemia. We studied the effects of transient focal ischemia on eNOS expression.",
"Wistar rats (n=72) underwent reversible filament occlusion of the right middle cerebral artery for 75 minutes. After 6, 24, 72, or 168 hours o... | eNOS protein is upregulated in pre- and postcapillary microvessels and upregulation appears slower after transient compared with permanent ischemia. Cyclooxygenase and NOS products do not play a major role in postischemic eNOS induction. | yes |
26871639 | Does gALNT14 genotype effectively predict the therapeutic response in unresectable hepatocellular carcinoma treated with transcatheter arterial chemoembolization? | [
"Transcatheter arterial chemoembolization is currently the standard treatment in hepatocellular carcinoma patients with Barcelona Clinic Liver Cancer stage B. Genomic variants of GALNT14 were recently identified as effective predictors for chemotherapy responses in Barcelona Clinic Liver Cancer stage C patients.",
... | GALNT14 genotypes were significantly associated with clinical outcomes of transcatheter arterial chemoembolization. The differential status of extrinsic apoptotic signaling between cancerous and non-cancerous tissues might underlie the clinical association. | yes |
27321488 | Do [ Effects of ulinastatin on immune function of patients with severe burn injury ]? | [
"To primarily evaluate the effects of ulinastatin on immune function of patients with severe burn injury.",
"Forty patients with severe burn admitted to our ward from March 2013 to October 2015, conforming to the study criteria, were divided into conventional treatment group (CT, n=20) and ulinastatin treatment g... | On the basis of CT, additional ulinastatin intervention can decrease CD4(+) CD25(+) Tregs percentage, improve the immune function of T lymphocytes and T helper cells, and increase expression of HLA-DR on CD14(+) monocytes of patients with severe burn injury, thus improve the immune function of patients. | yes |
26132438 | Does eMX2 be a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas? | [
"Squamous cell carcinomas (SCC) account for approximately 30% of non-small cell lung cancer (NSCLC). Current staging methods do not adequately predict outcome for this disease. EMX2 is a homeo-domain containing transcription factor known to regulate a key developmental pathway. This study assessed the significance ... | EMX2 expression is down-regulated in lung SCC and its down-regulation is associated with chemo-resistance in lung SCC cells, possibly through regulation of Epithelial-to-Mesenchymal Transition (EMT). EMX2 may serve as a novel prognostic marker for stage I lung SCC patients and a prediction marker for stage II/IIIA lung... | yes |
26857091 | Does obesity decrease B cell responses in young and elderly individuals? | [
"To evaluate the effects of obesity-associated inflammation on influenza vaccine responses.",
"In young and elderly individuals, both lean and with obesity, antibody responses to influenza vaccination were measured.",
"A decrease in in vivo vaccine responses, circulating switched memory, and transitional B cell... | These results demonstrate that leptin can be responsible for decreased B cell function in obesity. | yes |
25829004 | Is high-dose oral amoxicillin plus probenecid highly effective for syphilis in patients with HIV infection? | [
"Intramuscular benzathine penicillin G (BPG) is widely used for the treatment of syphilis. However, BPG is not available in some countries. This study examined the effectiveness and safety of high-dose oral amoxicillin plus probenecid for the treatment of syphilis in patients with human immunodeficiency virus type ... | The combination of oral amoxicillin 3 g plus probenecid was highly effective and tolerable for the treatment of syphilis in patients with HIV-1 infection. | yes |
27009328 | Does resolvin D1 mitigate energy metabolism disorder after ischemia-reperfusion of the rat lung? | [
"Energy metabolism disorder is a critical process in lung ischemia-reperfusion injury (LIRI). This study was aimed to determine the effects of resolvin D1 (RvD1) on the energy metabolism in LIRI.",
"Forty Sprague-Dawley rats were divided into the following groups: Sham group; untreated ischemia-reperfusion (IR) c... | RvD1 improves the energy metabolism of LIRI disturbance, protects the mitochondrial structure and function, increases the ATP, glycogen content and Na(+)-K(+)-ATPase activity of lung tissue, balances the ratio of ATP/ADP and finally decreases the rate of apoptosis, resulting in the protection of IR-induced lung injury.... | yes |
20449907 | Does intra-arrest rapid head cooling improve postresuscitation myocardial function in comparison with delayed postresuscitation surface cooling? | [
"To compare resuscitation outcomes and myocardial function among intra-arrest head cooling, delayed surface cooling, and uncooled controls.",
"Prospective animal study.",
"University-affiliated animal research laboratory.",
"Twenty-four male domestic pigs.",
"Ventricular fibrillation remained untreated for ... | Both intra-arrest head cooling and delayed surface cooling improved postresuscitation myocardial dysfunction. The beneficial effects were greatest with head cooling initiated with cardiopulmonary resuscitation. | yes |
23953508 | Does vertebroplasty increase compression of adjacent IVDs and vertebrae in osteoporotic spines? | [
"Approximately 25% of vertebroplasty patients experience subsequent fractures within 1 year of treatment, and vertebrae adjacent to the cemented level are up to three times more likely to fracture than those further away. The increased risk of adjacent fractures postaugmentation raises concerns that treatment of os... | These data indicate that vertebroplasty alters spine biomechanics resulting in increased compression of adjacent VB and IVD in severely osteoporotic women and may be the basis for clinical reports of adjacent fractures after vertebroplasty. | yes |
25038817 | Does sleep deprivation lead to a loss of functional connectivity in frontal brain regions? | [
"The restorative effect of sleep on waking brain activity remains poorly understood. Previous studies have compared overall neural network characteristics after normal sleep and sleep deprivation. To study whether sleep and sleep deprivation might differentially affect subsequent connectivity characteristics in dif... | The findings indicate that sleep deprivation most strongly affects the functional connectivity of prefrontal cortical areas. The findings extend those of previous studies, which showed sleep deprivation to predominantly affect functions mediated by the prefrontal cortex, such as working memory. Together, these findings... | yes |
23938169 | Does in vitro prion protein conversion suggest risk of bighorn sheep ( Ovis canadensis ) to transmissible spongiform encephalopathies? | [
"Transmissible spongiform encephalopathies (TSEs) affect both domestic sheep (scrapie) and captive and free-ranging cervids (chronic wasting disease; CWD). The geographical range of bighorn sheep (Ovis canadensis; BHS) overlaps with states or provinces that have contained scrapie-positive sheep or goats and areas w... | Our results indicate the in vitro conversion assay used in our study does mimic the species barrier of mice to the TSE agents that we tested. Based on Prnp genotype and results from conversion assays, BHS are likely to be susceptible to infection by classical scrapie. Despite mismatches in amino acids thought to modula... | yes |
18081936 | Does ubiquitination of HTLV-I Tax in response to DNA damage regulate nuclear complex formation and nuclear export? | [
"The HTLV-I oncoprotein, Tax, is a pleiotropic protein whose activity is partially regulated by its ability to interact with, and perturb the functions of, numerous cellular proteins. Tax is predominantly a nuclear protein that localizes to nuclear foci known as Tax Speckled Structures (TSS). We recently reported t... | This study demonstrates that the localization of Tax, and its interactions with cellular proteins, are dynamic following DNA damage and depend on the post-translational modification status of Tax. Specifically, DNA damage induces the ubiquitination of Tax at K280 and K284. Ubiquitination of these residues facilitates t... | yes |
16924009 | Does a new type of leukoencephalopathy with metaphyseal chondrodysplasia map to Xq25-q27? | [
"The authors report a three-generation family with four male patients presenting with a novel type of X-chromosomal leukoencephalopathy associated with skeletal abnormalities.",
"The index patient and his brother reached their early motor milestones in due time and had normal language development. Between the age... | The authors report a new type of leukoencephalopathy associated with metaphyseal chondrodysplasia located on Xq25-q27. | yes |
21880129 | Does a novel reporter of notch signalling indicate regulated and random Notch activation during vertebrate neurogenesis? | [
"Building the complex vertebrate nervous system involves the regulated production of neurons and glia while maintaining a progenitor cell population. Neurogenesis starts asynchronously in different regions of the embryo and occurs over a long period of time, allowing progenitor cells to be exposed to multiple extri... | A novel Notch reporter with multiple destabilisation elements provides a faithful read-out of endogenous Notch activity on a cell-by-cell basis, as neural progenitors progress through the cell cycle in the chick neural tube. Notch activity patterns in this cell population provide evidence for distinct Notch signalling ... | yes |
25659966 | Does a novel CGRP-neutralizing Spiegelmer attenuate neurogenic plasma protein extravasation? | [
"Calcitonin gene-related peptide (CGRP) plays an important role in the pathology of migraine, and recent clinical trials suggest the inhibition of CGRP-mediated processes as a new therapeutic option in migraine. In this study, we describe the generation of NOX-L41, a CGRP-neutralizing mirror-image (L-)aptamer (Spie... | This is the first description of the CGRP-neutralizing Spiegelmer NOX-L41. Preclinical studies confirmed a role for CGRP in neurogenic PPE and provided proof-of-concept for the potential use of this new drug candidate for the treatment or prevention of migraine. | yes |
24470399 | Are the 253-kb inversion and deep intronic mutations in UNC13D present in North American patients with familial hemophagocytic lymphohistiocytosis 3? | [
"The mutations in UNC13D are responsible for familial hemophagocytic lymphohistiocytosis (FHL) type 3. A 253-kb inversion and two deep intronic mutations, c.118-308C > T and c.118-307G > A, in UNC13D were recently reported in European and Asian FHL3 patients. We sought to determine the prevalence of these three non... | These specified non-coding mutations were found in a significant number of North American patients and inclusion of them in mutation analysis will improve the molecular diagnosis of FHL3. | yes |
15505451 | Does activation of A3 adenosine receptors attenuate lung injury after in vivo reperfusion? | [
"A3 adenosine receptor (AR) activation worsens or protects against renal and cardiac ischemia-reperfusion (IR) injury, respectively. The aims of the current study were to examine in an in vivo model the effect of A3AR activation on IR lung injury and investigate the mechanism by which it exerts its effect.",
"The... | In the feline lung, the A3AR agonist IB-MECA confers a powerful protection against IR lung injury. This effect is mediated by a nitric oxide synthase-independent pathway and involves opening of adenosine triphosphate-sensitive potassium channels. Therefore, selective activation of A3AR may be an effective means of prot... | yes |
21677571 | Does pain have a strong negative impact on the fluoxetine response in hospitalized patients with major depressive disorder? | [
"Response to an antidepressant is frequently the main goal in treating depression. The purpose of this study was to identify predictor(s) of response to the antidepressant, fluoxetine.",
"One hundred thirty-one newly hospitalized patients with major depressive disorder received fluoxetine (20 mg/d) for 6 weeks. S... | These findings from newly hospitalized patients with multiple pain measures support the previous studies, which enrolled mainly outpatients and found that a higher level of pain can have a strong negative impact on the antidepressant response. These data require confirmation and extension to outpatients and other antid... | yes |
24457037 | Do verbal working memory deficits predict levels of auditory hallucination in first-episode psychosis? | [
"Auditory verbal hallucinations are a characteristic symptom in schizophrenia. Recent causal models of auditory verbal hallucinations propose that cognitive mechanisms involving verbal working memory are involved in the genesis of auditory verbal hallucinations. Thus, in the present study, we investigate the hypoth... | Consistent with cognitive data from auditory verbal hallucinations in healthy individuals, the present results suggest a specific association between auditory verbal hallucinations, and cognitive processes involving the manipulation of phonological representations during a verbal working memory task. | yes |
24435852 | Is macular pigment optical density related to cognitive function in older people? | [
"the xanthophylls lutein (L) and zeaxanthin (Z) exist in relatively high concentration in multiple central nervous tissues (e.g. cortex and neural retina). L + Z in macula (i.e. macular pigment, MP) are thought to serve multiple functions, including protection and improvement of visual performance. Also, L + Z in t... | MPOD is related to cognitive function in older people. Its role as a potential biomarker of cognitive function deserves further study. | yes |
26002925 | Does low-Protein Diet-Induced Fetal Growth Restriction lead to Exaggerated Proliferative Response to Vascular Injury in Postnatal Life? | [
"We investigated the effects of fetal growth restriction (FGR) induced by maternal protein restriction on inflammatory vascular remodeling using a cuff-induced vascular injury mouse model.",
"Dams (C57BL/6J strain mice) were fed an isocaloric diet containing 20% protein (normal protein; NP) or 8% protein (low pro... | These results suggest that maternal low-protein diet-induced FGR increases susceptibility of the vasculature to postnatal injury. | yes |
7615196 | Does poly ( adenosine diphosphate ribose ) polymerase inhibition prevent necrosis induced by H2O2 but not apoptosis? | [
"H2O2 causes DNA damage, which activates poly(adenosine diphosphate ribose) polymerase (PARP), a nuclear enzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate. When DNA strand breaks are extensive, consumption of NAD by PARP can cause adenosine triphosphate depletion. The aim was to study the effe... | H2O2 induces two distinct death pathways in HT-29 cells: one that is immediate and may represent necrosis and another that is delayed, causing cell detachment leading to apoptosis. PARP inhibition prevents necrosis but has no effect on delayed cell detachment leading to apoptosis. | yes |
15354096 | Does axillary artery cannulation for cardiopulmonary bypass reduce cerebral microemboli? | [
"Aortic cannulation for cardiopulmonary bypass (CPB) is linked to cerebral microemboli emanating from the ascending aorta. Aortic calcification or disease requiring replacement precludes aortic cannulation. Clinical experience with axillary artery cannulation led to the hypothesis that axillary cannulation may be c... | Axillary artery cannulation for CPB is cerebroprotective. Altered blood-flow patterns during axillary cannulation may produce retrograde brachiocephalic artery blood flow and competing intracerebral right-to-left collateral blood flow, deflecting emboli from the ascending aorta and arch toward the descending aorta. Exp... | yes |
25620288 | Is atypical sensory processing common in extremely low gestational age children? | [
"Atypical sensory processing is common in children born extremely prematurely. We investigated sensory processing abilities in extremely low gestational age (ELGA) children and analysed associated neonatal risk factors, neuroanatomical findings and neurodevelopmental outcome.",
"We carried out a prospective study... | Atypical sensory processing in ELGA children was common, and children with neonatal neuroanatomical lesions tended to present specific behavioural responses to sensory stimuli. Surgical closure of the patent ductus arteriosus may predispose infants to feeding problems due to atypical oral sensory processing. | yes |
7638733 | Does allogeneic chimerism induce donor-specific tolerance to simultaneous islet allografts in nonobese diabetic mice? | [
"Nonobese diabetic (NOD) mice develop a systemic autoimmune disease that resembles type I diabetes in human beings. Previous studies in NOD mice have shown that transplantation of bone marrow from normal donors to lethally conditioned recipients prevented the development of diabetes (B10.BR-->NOD, BALB/c-->NOD). Th... | These data suggest that permanent donor-specific tolerance to islet allografts placed simultaneously with bone marrow transplantation can be achieved in diabetic NOD mice. Moreover, recurrent autoimmune destruction of the pancreatic tissue is prevented by the bone marrow chimerism. | yes |
17627746 | Is the Treatment Satisfaction Scale ( TSS ) a sensitive measure of treatment effectiveness for both patients and partners : results of a randomized controlled trial with vardenafil? | [
"Erectile dysfunction (ED) treatment studies do not routinely measure \"treatment effectiveness,\" a function of treatment response (based on efficacy and tolerability) and treatment satisfaction (both patient and partner satisfaction). The ED Treatment Satisfaction Scale (TSS) is a brief, comprehensive self-report... | The TSS detected that vardenafil was superior to placebo on treatment satisfaction from both patient and partner perspectives. The TSS holds promise for evaluating "treatment effectiveness" by measuring more general treatment satisfaction. | yes |
22584545 | Does the mu opioid receptor modulate neurotransmission in the rat spinal ventral horn? | [
"Opioids inhibit excitatory neurotransmission and produce antinociception through μ opioid receptors (MORs). Although MORs are expressed in the spinal ventral horn, their functions and effects are largely unknown. Therefore, we examined the neuromodulatory effects of μ opioids in spinal lamina IX neurons at the cel... | Our results suggest that DAMGO hyperpolarizes spinal lamina IX neurons by G protein-mediated activation of K(+) channels after activation of MORs. Furthermore, activation of MORs on presynaptic terminals reduces both excitatory and inhibitory transmitter release. Although traditionally opioids are not thought to affect... | yes |
9093212 | Is idiopathic hypogonadotropic hypogonadism in a male runner reversed by clomiphene citrate? | [
"To assess the efficacy of estrogen antagonist therapy on the function of the hypothalamic-pituitary-testicular axis in a young male runner with significant morbidity attributable to idiopathic hypogonadotropic hypogonadism.",
"An uncontrolled case study.",
"The outpatient endocrinology clinic of a university t... | Exercise-induced hypogonadotropic hypogonadism exists as a clinical entity among male endurance athletes, and CC may provide a safe and effective treatment option for males with debilitating hypogonadism related to endurance exercise. | yes |
22926332 | Does resveratrol improve myocardial ischemia and ischemic heart failure in mice by antagonizing the detrimental effects of fractalkine*? | [
"To test the hypothesis that resveratrol would improve cardiac remodeling by inhibiting the detrimental effects of fractalkine. We previously reported that fractalkine exacerbates heart failure. Furthermore, this study sought to determine whether resveratrol targets fractalkine to improve myocardial ischemia and ca... | Resveratrol alleviates the deleterious effects of fractalkine on myocardial ischemia and thus reduces subsequent cardiac remodeling. | yes |
22526583 | Does bin1 attenuation suppress experimental colitis by enforcing intestinal barrier function? | [
"Inflammatory bowel disease (IBD) is associated with defects in intestinal barriers that rely upon cellular tight junctions. Thus, identifying genes that could be targeted to enforce tight junctions and improve barrier function may lead to new treatment strategies for IBD.",
"This preclinical study aimed to evalu... | Bin1 is a genetic modifier of experimental colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions. Our findings offer a preclinical validation of Bin1 as a novel therapeutic target for IBD treatment. | yes |
22626487 | Do weight information labels on media models reduce body dissatisfaction in adolescent girls? | [
"To examine how weight information labels on variously sized media models affect (pre)adolescent girls' body perceptions and how they compare themselves with media models.",
"We used a three (body shape: extremely thin vs. thin vs. normal weight) × three (information label: 6-kg underweight vs. 3-kg underweight v... | Weight information labels may counteract the generally media-induced thin-body ideal. That is, when the weight labels appropriately informed the respondents about the actual thinness of the media model's body shape, girls were less affected. Weight information labels also instigated a normalization effect when a "norma... | yes |
27776905 | Does silver-Impregnated Occlusive Dressing reduce Rates of Acute Periprosthetic Joint Infection After Total Joint Arthroplasty? | [
"Commercial silver-impregnated occlusive dressings (such as Aquacel Ag Surgical wound dressing) have been touted as antimicrobial dressings to be used following total joint arthroplasty. Given the increased cost of an Aquacel dressing over a standard dressing for total joint arthroplasty, the objective of this stud... | This 4-fold decrease in acute PJI with the use of Aquacel dressing supports the use of silver-impregnated occlusive dressings for the reduction of acute PJI. | yes |
22073270 | Does preventive and therapeutic euphol treatment attenuate experimental colitis in mice? | [
"The tetracyclic triterpene euphol is the main constituent found in the sap of Euphorbia tirucalli. This plant is widely known in Brazilian traditional medicine for its use in the treatment of several kinds of cancer, including leukaemia, prostate and breast cancers. Here, we investigated the effect of euphol on ex... | Together, these results clearly demonstrated that orally-administered euphol, both preventive or therapeutic treatment were effective in reducing the severity of colitis in two models of chemically-induced mouse colitis and suggest this plant-derived compound might be a potential molecule in the management of inflammat... | yes |
18403726 | Does overexpression of ACE2 enhance plaque stability in a rabbit model of atherosclerosis? | [
"The purpose of this study was to test the hypothesis that ACE2 overexpression may enhance atherosclerotic plaque stability by antagonizing ACE activity and converting angiotensin II to angiotensin 1-7.",
"Atherosclerotic plaques were induced in the abdominal aorta of 114 rabbits by endothelial injury and atherog... | Overexpression of ACE2 results in stabilized atherosclerotic plaques and the mechanism is probably the conversion of vasoconstrictive angiotensin II to vessel protective angiotensin 1-7. | yes |
22576953 | Is high impact activity related to lean but not fat mass : findings from a population-based study in adolescents? | [
"Objective measures of physical activity calibrated against energy expenditure may have limited utility in studying relationships with musculoskeletal phenotypes. We wished to assess an alternative approach using an accelerometer calibrated according to impact loading.",
"Of the 17-year olds from the Avon Longitu... | Using an accelerometer calibrated according to impact loading revealed that high impact activity is related to lean but not fat mass. | yes |
10385080 | Is fulminant hepatitis significantly increased in hepatitis B carriers after allogeneic bone marrow transplantation? | [
"Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised.",
"Forty-three hepatitis B virus carriers rece... | Hepatitis B virus carriers receiving a marrow graft from an HbsAg+ donor have a significantly increased risk of FH. | yes |
23251612 | Is degeneration of the injured cervical cord associated with remote changes in corticospinal tract integrity and upper limb impairment? | [
"Traumatic spinal cord injury (SCI) leads to disruption of axons and macroscopic tissue loss. Using diffusion tensor imaging (DTI), we assessed degeneration of the corticospinal tract (CST) in the cervical cord above a traumatic lesion and explored its relationship with cervical atrophy, remote axonal changes withi... | Axonal degeneration of the CST in the atrophic cervical cord, proximal to the site of injury, parallels cranial CST degeneration and is associated with disability. This DTI protocol can be used in longitudinal assessment of microstructural changes immediately following injury and may be utilised to predict progression ... | yes |
17920974 | Are women less likely than men to receive prehospital analgesia for isolated extremity injuries? | [
"The goal of this study was to examine the effect of socioeconomic factors, such as ethnicity, income, age, and sex, on the administration of analgesia for isolated extremity injuries in the prehospital setting.",
"For this retrospective study, the electronic medical record of a large ground-based emergency medic... | This study suggests that women are less likely than men to receive prehospital analgesia for isolated extremity injuries. Patients with higher pain severity and longer duration of prehospital care are more likely to receive prehospital analgesia. Increasing levels of income were associated with increased rates of analg... | yes |
26927575 | Does state Laws on Emergency hold for Mental Health Stabilization? | [
"Psychiatric emergency hold laws permit involuntary admission to a health care facility of a person with an acute mental illness under certain circumstances. This study documented critical variation in state laws, identified important questions for evaluation research, and created a data set of laws to facilitate t... | The article highlights variability in state law for emergency holds of persons with acute mental illness. How this variability affects the individual, the treatment system, and law enforcement behavior is unknown. Research is needed to guide policy making and implementation on these issues. | yes |
23711612 | Are elevated levels of asymmetric dimethylarginine associated with lower CD4+ count and higher viral load in HIV-infected individuals? | [
"To compare asymmetric dimethylarginine (ADMA) among HIV-infected and uninfected individuals and to evaluate predictors of ADMA in HIV infection.",
"HIV-infected individuals have high rates of atherosclerosis. Endothelial dysfunction is central to atherogenesis and is one possible mechanism underlying this increa... | ADMA levels were modestly elevated in the setting of HIV infection. Notably, a greater HIV-associated inflammatory burden, as evidenced by lower CD4+ counts and higher viral loads, was associated with increased ADMA levels. Our findings suggest that HIV infection impairs endothelial function and predisposes to atherosc... | yes |
18983676 | Does quantification of gamma-secretase modulation differentiate inhibitor compound selectivity between two substrates Notch and amyloid precursor protein? | [
"Deposition of amyloid-β protein (Aβ) is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from γ-secretase cleavage of amyloid precursor protein (APP). In addition to APP, γ-secretase also cleaves other type I integral membrane proteins, including the Notch receptor, a key molecule involve... | Our ELISA-based quantification of Aβ and Nβ* in combination with the test in zebrafish provides a novel approach for efficient cell-based screening and in vivo validation of APP selective γ-secretase inhibitors. | yes |
25215085 | Does language affect length of stay in emergency departments in Queensland public hospitals? | [
"A long length of stay (LOS) in the emergency department (ED) associated with overcrowding has been found to adversely affect the quality of ED care. The objective of this study is to determine whether patients who speak a language other than English at home have a longer LOS in EDs compared to those whose speak on... | There is a close relationship between the language spoken at home and the LOS at EDs, indicating that language could be an important predictor of prolonged LOS in EDs and improving language services might reduce LOS and ease overcrowding in EDs in Queensland's public hospitals. | yes |
26418954 | Does eGFRvIII affect radiosensitivity with or without gefitinib treatment in glioblastoma cells? | [
"Glioblastomas (GBM) are often characterized by an elevated expression of the epidermal growth factor receptor variant III (EGFRvIII). We used GBM cell lines with native EGFRvIII expression to determine whether this EGFR variant affects radiosensitivity with or without EGFR targeting.",
"Experiments were performe... | The data indicate that EGFRvIII does not alter radiosensitivity with or without anti-EGFR treatment. | no |
20622476 | Is v-shaped trough in autonomic activity a possible precursor of life-threatening cardiac events? | [
"No reliable precursor of sudden cardiac death is known.",
"Holter electrocardiograms of 34 patients experiencing a cardiac event (event group, 20 deaths) were compared with 191 controls (no event group). The event group included 25 patients with ventricular fibrillation or acute myocardial infarction (AMI), and ... | A previously unidentified V-trough of autonomic activity is a potential precursor of lethal events. | yes |
18824880 | Does caffeic acid phenethyl ester induce apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction? | [
"This study aimed to investigate the effect of caffeic acid phenethyl ester (CAPE), an active component isolated from honeybee propolis, in inducing apoptosis in human pancreatic cancer cells.",
"Inhibition of viability of BxPC-3 and PANC-1 cell lines induced by CAPE was estimated by a trypan blue dye exclusion t... | These results suggest that CAPE is a potent apoptosis-inducing agent. Its action is accompanied by mitochondrial dysfunction and activation of caspase-3/caspase-7. | yes |
23391698 | Is the prognostic significance of heart rate recovery dependent upon maximal effort in patients with heart failure? | [
"Heart rate recovery (HRR) has been observed to be a significant prognostic measure in patients with heart failure (HF). However, the prognostic value of HRR has not been examined in regard to the level of patient effort during exercise testing. Using the peak respiratory exchange ratio (RER) and a large multicente... | HRR after symptom-limited exercise testing performed at sub-maximal efforts using RER to categorize level of effort is as predictive as HRR after maximal effort in HF patients. | no |
25172009 | Does left atrial deformation predict success of first and second percutaneous atrial fibrillation ablation? | [
"Predictors of second radiofrequency catheter ablation (RFCA) success are not well known. Surgical ablation is accepted for failed first RFCA, but second RFCA has fewer complications.",
"The purpose of this study was to evaluate left atrial (LA) size and function as potential predictors of second RFCA for atrial ... | LA myocardial deformation imaging is a reliable tool for predicting success after a first and a second RFCA. These parameters could improve candidate selection, especially for a second RFCA. | yes |
27536892 | Does α-Solanine modulate the Radiosensitivity of Esophageal Cancer Cells by Inducing MicroRNA 138 Expression? | [
"Esophageal cancer (EC) is one of the most common malignant tumors in the world. Due to difficulties with performing the operation, most patients choose to have palliative treatment instead. Radiotherapy is one of the main palliative treatments of EC. However, the clinical efficacy of radiotherapy is not satisfacto... | α-solanine could enhance the radiosensitivity of esophageal cancer cells by inducing microRNA-138 expression, and probably be an effective radiosensitizer in treating EC. | yes |
22724438 | Do quantification studies in human seminal plasma samples identify prolactin inducible protein as a plausible marker of azoospermia? | [
"Prolactin inducible protein (PIP) is a ~17 kDa protein, which is known to play vital roles in immunoregulation, fertility, antimicrobial activity, apoptosis and tumour progression.",
"This study reports quantification of PIP concentration in human seminal plasma (SP) samples.",
"PIP was purified by immunopreci... | There was no significant variation in PIP levels in normozoospermia and oligozoospermia while its expression was down-regulated in azoospermia, indicating that PIP may be a plausible marker of azoospermia. | yes |
19621727 | Is metastatic lymph node ratio an independent prognostic factor in gastric cancer? | [
"The metastatic status of the regional lymph node is the most significant prognostic factor for gastric cancer. However, diverse prognoses are evident even among the same N classifications of the current tumor-node-metastasis system. The aim of this study is to evaluate the prognostic significance of the ratio of m... | N ratio can be recommended as an applicable parameter for lymph node involvement of gastric cancer. It is a more effective and precise indicator for prognostic stratification of patients with lymph node positive gastric cancer than the current N classification of the tumor-node-metastasis system. | yes |
21586687 | Are small bowel adenocarcinoma copy number profiles more closely related to colorectal than to gastric cancers? | [
"Small bowel adenocarcinoma (SBA) is a rare cancer and consequently, the options for clinical trials are limited. As they are treated according to either a colorectal or a gastric cancer regimen and the molecular biology of a tumor is a pivotal determinant for therapy response, chromosomal copy number aberrations w... | We show that MSS SBAs are more similar to colorectal than to gastric cancer, based on the 27 genome-wide DNA copy number profiles that are currently available. These molecular similarities provide added support for treatment of MSS small bowel cancers according to colorectal cancer regimens. | yes |
11276494 | Does 3D-visualization improve the dry-lab coronary anastomoses using the Zeus robotic system? | [
"Robotic surgical instruments enable quick and precise movements and may allow complete endoscopic coronary artery bypass grafting. However, cardiac surgeons will have to become familiar with this technology and endoscopic viewing. We present our training program with special focus on 2D- and 3D-visualization.",
... | A surgical training program is mandatory to become familiar with these new technologies. Both models showed learning curves over an acceptable time course. 3D-visualization facilitated quick and precise movements, thus resulting in shorter anastomosis times. | yes |
19192231 | Does high-pitched breath sound indicate airflow limitation in asymptomatic asthmatic children? | [
"Asthmatic children may have airway dysfunction even when asymptomatic, indicating that their long-term treatment is less than optimal. Although airway dysfunction can be identified on lung function testing, performing these tests can be difficult in infants. We studied whether breath sounds reflect subtle airway d... | Higher HFI in asymptomatic asthmatic children may indicate small airway obstruction. Additional ICS treatment may improve the pulmonary function indices representing small airway function with simultaneous HFI decreases in such patients. | yes |
25562150 | Does insulin influence autophagy response distinctively in macrophages of different compartments? | [
"Diabetes mellitus (DM) is characterized by hyperglycemia, associated to a lack or inefficiency of the insulin to regulate glucose metabolism. DM is also marked by alterations in a diversity of cellular processes that need to be further unraveled. In this study, we examined the autophagy pathway in diabetic rat mac... | Taking these results together, diabetic macrophages derived from different compartments show different levels of autophagy markers compared to healthy animals, therefore, they suffer distinctively in the absence of insulin. | yes |
7657111 | Do correlation of high-frequency esophageal ultrasonography and manometry in the study of esophageal motility? | [
"No studies correlate manometric measurements with morphological changes during the esophageal peristaltic sequence. The aim of this study was to develop and use a system for sonographically imaging the esophageal wall while simultaneously recording esophageal pressure changes.",
"An ultrasonography transducer at... | A combined ultrasonography transducer/manometry probe was used to dynamically and simultaneously evaluate esophageal wall motion, muscle thickness, and esophageal pressure changes during peristalsis. | yes |
16318659 | Does hyperbaric bupivacaine affect the doses of midazolam required for sedation after spinal anaesthesia? | [
"Patients having spinal anaesthesia with hyperbaric bupivacaine may become sensitive to sedative drugs but no data exists about any dose-related effect of the local anaesthetic on the sedative requirement. We aimed to investigate whether hyperbaric bupivacaine dose in spinal anaesthesia has any effect on midazolam ... | Different doses of hyperbaric bupivacaine for spinal anaesthesia do not affect the midazolam requirements for sedation. However, spinal anaesthesia with hyperbaric bupivacaine with a maximum spread in the middle thoracic dermatomes may be associated with sedative effects and thus a reduced need for further sedation wit... | yes |
19401373 | Do low serum testosterone and estradiol predict mortality in elderly men? | [
"Age-related reduction of serum testosterone may contribute to the signs and symptoms of aging, but previous studies report conflicting evidence about testosterone levels and male mortality. No large prospective cohort study has determined a possible association between serum estradiol and mortality in men.",
"Th... | Elderly men with low serum testosterone and estradiol have increased risk of mortality, and subjects with low values of both testosterone and estradiol have the highest risk of mortality. | yes |
17854390 | Do effects of the progestagen-only contraceptive implant Implanon on cardiovascular risk factors? | [
"Epidemiological studies on the cardiovascular risk of progestagen-only contraceptives are rare. With the present study we aimed to investigate the effect of the low-dose etonogestrel-releasing contraceptive implant Implanon on cardiovascular risk factors, including markers of inflammation.",
"Longitudinal study.... | The progestagen-only implant Implanon does not exert a negative effect on the cardiovascular risk factors CRP, cholesterol/HDL ratio and NO. These results suggest that the use of a progestagen-only contraception does not increase cardiovascular risk factors in healthy young women. | yes |
25267530 | Does a low-dose regimen of cisplatin before high-dose cisplatin potentiate ototoxicity? | [
"Cochlear preconditioning with low doses of kanamycin or noise can reduce susceptibility to noise- and ototoxic drug-induced hearing loss. The current study was undertaken to investigate whether a preconditioning regimen of low-dose cisplatin would alter susceptibility to ototoxicity induced by a single large dose ... | Preconditioning with low-dose cisplatin, using the protocol applied in the current experiment, created potentiation of cisplatin ototoxicity, rather than protection from it. There are numerous possible explanations for this effect that should be considered. | yes |
22753720 | Does protein-bound polysaccharide-K ( PSK ) induce apoptosis via p38 mitogen-activated protein kinase pathway in promyelomonocytic leukemia HL-60 cells? | [
"Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma. We have previously demonstrated that PSK induces apoptosis and inhibites proliferation of promyelomonocytic leukemia HL-60 cell... | The p38 MAPK pathway plays an important role in PSK-induced apoptosis. | yes |
18959698 | Is laparoscopy in suspected abdominal tuberculosis useful as an early diagnostic method? | [
"Establishing a histological diagnosis in abdominal tuberculosis can be difficult, frequently delaying treatment. The aim of the study was to evaluate the role of laparoscopy for ascertaining the diagnosis in suspected abdominal tuberculosis.",
"A retrospective review was undertaken of patients who underwent diag... | In patients suspected to have abdominal tuberculosis without evidence of extra-abdominal disease, early laparoscopy may be useful to establish a histological diagnosis with acceptably low morbidity (8%). Frozen section is useful to assess adequacy of biopsy and sampling. An extensive work-up may hence be averted by a t... | yes |
19364691 | Is minimal reduction in insulin dosage with pramlintide therapy when pretreatment near-normal glycemia established and square-wave meal bolus is used? | [
"To evaluate the effect of near-normal glucose control before initiation of pramlintide therapy and square-wave meal bolus on self-reported hypoglycemia and the percentage change in dosing parameters after attaining the maximum pramlintide dosage.",
"In this prospective study, insulin pump-treated patients with t... | Patients with near-normal glucose control who use a square-wave bolus may not need initial bolus dosage reduction. With weight loss, small adjustments in both TBD and ICR may be required. Greater incidence of hypoglycemia seen in previous studies may in part be due to mismatched insulin dosing. | yes |
21346223 | Does neurofilament heavy chain in CSF correlate with relapses and disability in multiple sclerosis? | [
"Neurodegeneration is now accepted as a pathologic hallmark of multiple sclerosis (MS). We sought to discover whether CSF levels of neurofilament heavy chain protein (NfH(SMI35)) correlate with disability, disease activity, or specific stages of MS.",
"An electrochemiluminescence immunoassay was used to retrospec... | Neuronal loss is a feature of aging, and the age-dependent increase of CSF NfH(SMI35) suggests that this loss accelerates over time. For MS, increased NfH(SMI35) levels reflect the superimposed presence of further neurodegenerative processes. Evaluation of NfH(SMI35) levels is likely to provide a useful surrogate for m... | yes |
19473897 | Do gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation? | [
"Exosomes are nanometer-sized vesicles that are released by normal and neoplastic cells. Previous studies have focused on the interaction between tumour-derived exosomes and the immune system, as a consequence of immune suppression or enhancement. However, the effects of tumour-derived exosomes on tumour cells them... | Gastric cancer exosomes promoted tumour cell proliferation, at least in part, by activation of PI3K/Akt and mitogen-activated protein kinase/extracellular-regulated protein kinase pathways. The decreased expression of Casitas B-lineage lymphoma proteins might have contributed to the activation of Akt and extracellular-... | yes |
21193745 | Is soluble glycoprotein VI raised in the plasma of patients with acute ischemic stroke? | [
"Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding.",
"We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic str... | Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke. | yes |
11939943 | Do serum cytokine levels correlate with disease activity and severity assessed by brain MRI in multiple sclerosis? | [
"Chronic and acute dysregulation of the cytokine network has been described in multiple sclerosis (MS). Inflammatory lesions in the central nervous system of MS patients can be assessed by brain magnetic resonance imaging (MRI). This study has been performed to investigate whether changes of cytokines correlate wit... | Our data show that the determination of serum levels of the investigated cytokines and cytokine receptors is not useful as a tool to determine subclinical disease activity and severity as assessed by brain MRI. | no |
24595452 | Does lycium barbarum polysaccharide prevent focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice? | [
"To investigate the neuroprotective effect of Lycium barbarum polysaccharide (LBP) on focal cerebral ischemic injury in mice and to explore its possible mechanism.",
"Male ICR mice were used to make the model of middle cerebral artery occlusion (MCAO) after intragastric administration with LBP (10, 20 and 40 mg/k... | Based on these findings we propose that LBP protects against focal cerebral ischemic injury by attenuating the mitochondrial apoptosis pathway. | yes |
12394950 | Is angiotensin converting enzyme DD genotype associated with hypertensive crisis? | [
"The genetic background of hypertensive crisis is unknown. We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis.",
"Population-based case-control study.",
"Emergency department at a tertiary care university hospital.",
"A total of ... | We demonstrate a possible association of the DD genotype with hypertensive crisis in men. | yes |
25898829 | Does pan-genome dynamics of Pseudomonas gene complement enriched across hexachlorocyclohexane dumpsite? | [
"Phylogenetic heterogeneity across Pseudomonas genus is complemented by its diverse genome architecture enriched by accessory genetic elements (plasmids, transposons, and integrons) conferring resistance across this genus. Here, we sequenced a stress tolerant genotype i.e. Pseudomonas sp. strain RL isolated from a ... | Unlocking the potential of comparative genomics supplemented with metagenomics, we have attempted to resolve the environment and strain specific demarcations across 18 Pseudomonas gene complements. Pan-genome analyses of these strains indicate at astoundingly diverse metabolic strategies and provide genetic basis for t... | yes |
22886508 | Does angiotensin II type 1 receptor antagonist prevent hepatic carcinoma in rats with nonalcoholic steatohepatitis? | [
"Angiotensin II type 1 receptor blockers (ARBs) have been reported to attenuate hepatic fibrosis in non-alcoholic steatohepatitis (NASH). However, it is uncertain whether ARBs prevent hepatocarcinogenesis in NASH even after hepatic fibrosis has developed.",
"Male Wistar rats were fed with a choline-deficient, L-a... | These data indicated that telmisartan may prevent hepatocarcinogenesis through the inhibition of hepatic angiogenesis even after liver cirrhosis has been established. | yes |
20804777 | Does copulation modify AR and ERα mRNA expression in the male rat brain? | [
"One day after male sexual behavior [one ejaculation or copulation to satiety (ad libitum copulation during 4h with the same female)] androgen receptor immunoreactivity (AR-ir) is decreased and estrogen receptor alpha immunoreactivity (ERα-ir) increased in various brain areas related with its control. Seven days af... | In some brain areas and after some intervals of sexual activity, the changes in steroid protein receptors expression seem to be consequence of parallel changes in the expression of the respective mRNA. | yes |
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