id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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18082986 | Does nizatidine enhance salivary secretion in patients with dry mouth? | [
"It was reported that salivary secretion increased in 30 volunteers with administered nizatidine. The aim of the present study was to investigate whether or not nizatidine enhances salivary secretion and improves the function of salivary glands in patients with dry mouth.",
"Both basal and stimulated salivary sec... | Nizatidine may reactivate salivary gland cells and be useful in the treatment of patients with dry month. | yes |
16571126 | Are female smokers beyond the perimenopausal period at increased risk of chronic obstructive pulmonary disease : a systematic review and meta-analysis? | [
"Recent reports indicate that over the next decade rates of chronic obstructive pulmonary disease (COPD) in women will exceed those in men in the western world, though in most jurisdictions, women continue to smoke less compared with men. Whether female adult smokers are biologically more susceptible to COPD is unk... | As female smokers age, they appear to experience an accelerated decline in FEV1% predicted compared with male smokers. Future research powered specifically on gender-related changes in lung function is needed to confirm these early findings. | yes |
25691844 | Is old age at diagnosis associated with favorable outcomes in korean patients with inflammatory bowel disease? | [
"Despite the rising incidence and prevalence of inflammatory bowel disease (IBD) in Asian populations, data regarding clinical characteristics of patients in Asia based on age at diagnosis are relatively sparse. The aim of this study was to compare clinical characteristics based on the age at diagnosis according to... | Age at diagnosis according to the Montreal Classification is an important prognostic factor for Korean IBD patients. | yes |
22918644 | Is choroidal thickness change after water drinking greater in angle closure than in open angle eyes? | [
"To study change in choroidal thickness (CT) after water drinking test (WDT), comparing angle closure (AC) to open angle (OA) eyes.",
"Before and 30 minutes after drinking 1 L of water, 88 glaucoma subjects underwent measurements of CT by spectral domain-optical coherence tomography, IOP, blood pressure (BP), axi... | A significant increase in CT and a decrease in ACD after WDT were observed in AC but not in OA eyes, and IOP increased significantly more in AC than in OA eyes, suggesting that the dynamic behavior of the choroid may play a role in the AC process. IOP increase after the WDT was not fully explained by CT increase. | yes |
14718696 | Does effect of age on MSLT result in patients with narcolepsy-cataplexy? | [
"To measure the effect of age on Multiple Sleep Latency Test (MSLT)characteristics, sleep latency, and number of sleep-onset REM periods (SOREMP) in two large populations of narcoleptic patients with similar genetic backgrounds.",
"Clinical and polygraphic information on the severity of the condition was obtained... | The progressive decrease in the number of SOREMP and increase in the mean sleep latency on the MSLT as a function of age suggest that the current criteria used for diagnosis may be too stringent in older patients. The major influence of age on MSLT results should therefore be taken into account when diagnosing a narcol... | yes |
23638630 | Do dNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population? | [
"DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMTs). In cancer cells, global hypomethylation of the genome as a whole and regional hypermethylation of CpG ... | We conclude that women with the DNMT1 SNP (A201G, rs2228612) GG homozygous genotype (variant) have a lower risk of developing breast cancer compared to heterozygous or wildtype genotypes. To date, alterations within the DNMT1 gene have not been reported to be associated with cancer in the Caucasian population. | yes |
25962169 | Do identification of two metallothioneins as novel inhalative coffee allergens cof a 2 and cof a 3? | [
"Dust of green coffee beans is known to be a relevant cause for occupational allergic disorders in coffee industry workers. Recently, we described the first coffee allergen (Cof a 1) establishing an allergenic potential of green coffee dust.",
"Our aim was to identify allergenic components of green coffee in orde... | In addition to the previously described Cof a 1 we have identified two further coffee proteins to be type I coffee allergens (Cof a 2 and Cof a 3) which may have a relevant potential for the specific diagnosis and/or therapy of coffee allergy. | yes |
22319680 | Do muscle activation of the torso during the modified razor curl hamstring exercise? | [
"The RAZOR curl has been introduced as a hamstring exercise. However, modifications to the exercise have been developed which are proposed to utilize some of the muscles of the lumbo-pelvic-hip complex. Thus, it was the purpose of this study to quantitatively examine the modified RAZOR curl using surface electromyo... | These findings allow the practitioner to utilize an exercise that provides a functional training stimulus that activates not only the hamstrings but also some musculature of the trunk muscles of the lumbopelvic-hip complex at strong to moderately strong levels. | yes |
22328092 | Does high-density lipoprotein lose its anti-inflammatory capacity by accumulation of pro-inflammatory-serum amyloid A? | [
"High-density lipoprotein (HDL) is known to have potent anti-inflammatory properties. Monocyte chemoattractant protein-1 is an important pro-inflammatory cytokine in early atherogenesis. There is evidence that HDL can lose its protective function during inflammatory disease. In patients with end-stage renal disease... | These results suggest that SAA enrichment of HDL during disease conditions contributes to the decreased protective function. It is a novel finding that SAA acts as a pro-inflammatory molecule to reduce the anti-inflammatory properties of HDL. | yes |
18167167 | Is fish consumption a safe solution to increase the intake of long-chain n-3 fatty acids? | [
"Dietary intake of long-chain (LC) n-3 PUFA in developed countries is low compared with recommendations. Fish is naturally rich in LC n-3 PUFA, but is also a dietary source of heavy metals and organic pollutants. We investigated whether the recommendation for LC n-3 PUFA could be reached through fish consumption, w... | Combination of regular fish consumption (twice a week) with important contribution of fatty fish species, in combination with regular consumption of margarine enriched with EPA + DHA, can be advised to achieve the recommendation for LC n-3 intake. | yes |
22403241 | Does interaction between NFκB and NFAT coordinate cardiac hypertrophy and pathological remodeling? | [
"Both nuclear factors of activated T cells (NFAT) and nuclear factor-κB (NFκB) are Rel homology domain (RHD)-containing transcription factors whose independent activities are critically involved in regulating cardiac hypertrophy and failure.",
"To determine the potential functional interaction between NFAT and NF... | Our results suggest a direct interaction between NFAT and NFκB that effectively integrates 2 disparate signaling pathways in promoting cardiac hypertrophy and ventricular remodeling. | yes |
16997402 | Is renal dysfunction an independent predictor of in-hospital mortality in patients with ST-segment elevation myocardial infarction treated with primary angioplasty? | [
"Patients with baseline renal dysfunction (BRD) have an increased cardiovascular risk and a worse prognosis after an acute myocardial infarction (AMI). Besides, the appearance of worsening renal failure (WRF) after an AMI is an independent predictor of worse prognosis too. The aim of the present study was to determ... | BRD was an independent predictor of in-hospital mortality in patients with STEMI who underwent successful PA. Likewise, WRF occurring in these patients was an independent predictor of in-hospital mortality too. | yes |
8558725 | Does exercise training improve functional status in patients with peripheral arterial disease? | [
"In patients with intermittent claudication (IC) a structured walking exercise program improves exercise performance. However, few studies have evaluated the effects of exercise training on functional status during daily activities. We hypothesized that a supervised exercise training program would improve functiona... | A supervised treadmill training program improved functional status during daily activities, with 24 weeks more effective than 12. In addition, treadmill training alone was more effective in improving functional status in patients with IC than strength training or combinations of the training modalities. | yes |
23340164 | Is high-normal diastolic blood pressure a risk for development of microalbuminuria in the general population : the Watari study? | [
"Although hypertension is a well known risk factor for microalbuminuria, it is unclear whether blood pressure less than 140/90 mmHg could be a risk for microalbuminuria. We assessed the relationship between baseline blood pressure and the future onset of microalbuminuria in the general population.",
"We studied 2... | High-normal DBP associated with metabolic disorders could initiate glomerular damage, leading to future microalbuminuria. | yes |
20668704 | Do two bee-pollinated plant species show higher seed production when grown in gardens compared to arable farmland? | [
"Insect pollinator abundance, in particular that of bees, has been shown to be high where there is a super-abundance of floral resources; for example in association with mass-flowering crops and also in gardens where flowering plants are often densely planted. Since land management affects pollinator numbers, it is... | The results show that pollination services can limit fruit set of wild plants in arable farmland, but there is some evidence that the presence of a flowering crop can facilitate their pollination (depending on species and season). We have also demonstrated that gardens are not only beneficial to pollinators, but also t... | yes |
20645026 | Does the FOUR score predict outcome in patients after cardiac arrest? | [
"Prognostication for survivors of cardiac arrest is a frequent challenge to neurologists. Our aim was to determine whether the FOUR (Full Outline of UnResponsiveness) score is an accurate predictor of outcome in patients after cardiac arrest and to compare its performance to the Glasgow Coma Scale (GCS).",
"We pr... | The FOUR score, a simple clinical tool, is an accurate predictor of outcome in patients surviving cardiac arrest. | yes |
25684033 | Does bupivacaine inhibit endothelin-1-evoked increases in intracellular calcium in model sensory neurons? | [
"Endothelin-1 (ET-1) induces pain-like behavior in animals and man by activating the Gq protein-coupled receptor endothelin-A (ETA ). Activation of ETA receptors on nociceptor membranes evokes intracellular calcium transients and alters membrane Na(+) and K(+) channel and TRPV1 currents, leading to neuronal hyper-e... | Bupivacaine inhibits ETA -mediated calcium transients at clinically relevant concentrations through an intracellular target. The anti-inflammatory and analgesic actions of bupivacaine may be at least partially due to its inhibitory action on Gq -coupled receptors, including ETA. | yes |
27708849 | Does highly purified eicosapentaenoic acid ameliorate cardiac injury and adipose tissue inflammation in a rat model of metabolic syndrome? | [
"n-3 Polyunsaturated fatty acids such as eicosapentaenoic acid (EPA), which are abundant in fish oil, have been shown to delay the onset of cardiovascular events. We previously established DahlS.Z-",
"DS/obese rats were administered EPA (300 or 1,000 mg kg",
"Whereas EPA had no effect on body weight, food intak... | Treatment of DS/obese rats with EPA did not affect hypertension but reduced cardiac fibrosis and diastolic dysfunction, with the latter effects being accompanied by AMP-activated protein kinase activation and inactivation of nuclear factor-kB signalling in the heart, possibly as a result of an increase in adiponectin s... | yes |
25934693 | Does miR-19-Mediated Inhibition of Transglutaminase-2 lead to Enhanced Invasion and Metastasis in Colorectal Cancer? | [
"Transglutaminase-2 (TG2) is a critical cross-linking enzyme in the extracellular matrix (ECM) and tumor microenvironment (TME). Although its expression has been linked to colorectal cancer, its functional role in the processes that drive disease appears to be context dependent. There is now considerable evidence o... | Chromosome-13 amplification in advanced colorectal cancer contributes to invasion and metastasis by upregulating miR-19, which targets TG2. | yes |
18522757 | Do unique motifs identify PIG-A proteins from glycosyltransferases of the GT4 family? | [
"The first step of GPI anchor biosynthesis is catalyzed by PIG-A, an enzyme that transfers N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol. This protein is present in all eukaryotic organisms ranging from protozoa to higher mammals, as part of a larger complex of five to six 'accessory' pro... | Besides identifying unique motifs and showing that PIG-A protein from G. lamblia and some putative PIG-A proteins from archaebacteria are evolutionarily closer to glycosyltransferases, these studies provide a new method for identification and classification of PIG-A proteins. | yes |
16530518 | Does brain-derived neurotrophic factor augment peristalsis by augmenting 5-HT and calcitonin gene-related peptide release? | [
"Brain-derived neurotrophic factor (BDNF) acts rapidly to modulate synaptic neurotransmission in the brain. Although present in neurons, glial cells, and mucosal cells of the colon, and in higher concentrations than in brain, the action of BDNF in gut have not been characterized. The aim of this study was to identi... | Endogenous BDNF enhances the peristaltic reflex by augmenting the release of serotonin and calcitonin gene-related peptide that mediate the sensory limb of the reflex induced by mucosal stimulation. | yes |
20067472 | Does the mixed-lineage kinase 1-3 signalling pathway regulate stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors? | [
"The mixed-lineage kinases (MLKs) act upstream of mitogen-activated protein kinases, but their role in cardiac biology and pathology is largely unknown.",
"We investigated the effect of a MLK1-3 inhibitor CEP-11004 on G protein-coupled receptor agonist-induced stress response in neonatal rat cardiac myocytes in c... | These results showed that inhibition of the MLK1-3 signalling pathway was sufficient for suppressing the activity of key nuclear effectors (GATA-4 and activator protein-1 transcription factors) in cardiac hypertrophy, and attenuated the agonist-induced atrial natriuretic peptide secretion and activation of BNP gene tra... | yes |
17373740 | Does uric acid enhance T cell immune responses to hepatitis B surface antigen-pulsed-dendritic cells in mice? | [
"To study the induction of T cellular immune responses in BALB/c mice immunized with uric acid and dendritic cells (DCs) pulsed with hepatitis B virus surface antigen (HBsAg).",
"DCs were generated from bone-marrow cells of BABL/c mice, and then pulsed or unpulsed with HBsAg protein (HBsAg-pulsed-DCs or unpulsed-... | Uric acid can strongly enhance T cell immune responses induced by HBsAg-pulsed-DCs vaccine. Uric acid may serve as an effective adjuvant of DC vaccine against HBV infection. | yes |
23392358 | Do the safety and efficacy of parenteral nutrition among pediatric patients with burn injuries? | [
"Although enteral nutrition is the ideal mode of nutritional support following burn injury, it is often interrupted during episodes of severe sepsis and hemodynamic instability, leading to significant energy and protein deficits. Parenteral nutrition is not commonly used in burn centers due to concerns that it will... | Judicious use of parenteral nutrition is a safe and effective means of nutritional support when goal enteral nutrition cannot be achieved. A hypocaloric, high-nitrogen parenteral nutrition solution can reduce energy and protein deficits while minimizing complications commonly associated with parenteral nutrition usage. | yes |
9706135 | Do dendritic cells improve the generation of Epstein-Barr virus-specific cytotoxic T lymphocytes for the treatment of posttransplantation lymphoma? | [
"The use of immunosuppressive therapies after solid organ transplantation has been shown to increase a patient's risk for Epstein-Barr virus (EBV)-associated lymphoma. A potential therapy for this disorder is the adoptive transfer of EBV-specific cytotoxic T lymphocytes (CTLs). We proposed that dendritic cells (DCs... | DCs improved the in vitro generation of EBV-specific CTLs as evidenced by this group's significantly increased lytic activity over that of the control group. The improved lytic activity of DC-generated EBV-CTLs suggests that adoptive transfer of these cells could lead to a more effective immunotherapeutic response agai... | yes |
12196217 | Do efficiency of the 0.04 taper ProFile during the re-treatment of gutta-percha-filled root canals? | [
"The objective of this study was to determine the effectiveness of 0.04 ProFile instruments during the removal of root fillings.",
"A total of 30 single-rooted mandibular canines were divided into three groups. The canals were accessed and then prepared with a reciprocating automated device and nickel-titanium fi... | ProFile instruments with 0.04 taper were inadequate in completely removing the filling materials from the root canal system. However, the ideal working length was achieved rapidly. | yes |
16123330 | Does endothelial cell activation by IL-1beta in the presence of fibrinogen require alphavbeta3? | [
"The purpose of this study was to investigate the receptor requirements for enhanced IL-1beta-induced secretion of nitric oxide (NO) by endothelial cells (ECs) in the presence of fibrinogen.",
"ECs were exposed to IL-1beta with or without fibrinogen and NO was measured as nitrite. NO production by EC exposed to f... | The enhanced NO production by ECs in the presence of fibrinogen-bound IL-1beta requires the coordinated effects of colocalized alphavbeta3 and IL-1R. | yes |
20066738 | Does hepatopoietin Cn suppress apoptosis of human hepatocellular carcinoma cells by up-regulating myeloid cell leukemia-1? | [
"To investigate the role of hepatopoietin Cn (HPPCn) in apoptosis of hepatocellular carcinoma (HCC) cells and its mechanism.",
"Two human HCC cell lines, SMMC7721 and HepG2, were used in this study. Immunostaining, Western blotting and enzyme linked immunosorbent assay were conducted to identify the expression of... | HPPCn is a novel hepatic growth factor that can be secreted to CM and suppresses apoptosis of HCC cells by up-regulating Mcl-1 expression. | yes |
9107164 | Are vascular effects of acute hyperglycemia in humans reversed by L-arginine . Evidence for reduced availability of nitric oxide during hyperglycemia? | [
"Acute hyperglycemia may increase vascular tone in normal humans via a glutathione-sensitive, presumably free radical-mediated pathway. The objective of this study was to investigate whether or not the vascular effects of hyperglycemia are related to reduced availability of nitric oxide.",
"Acute hyperglycemia (1... | The results show that acute hyperglycemia in normal subjects causes significant hemodynamic and rheological changes that are reversed by L-arginine. Moreover, the effects of hyperglycemia are mimicked to a large extent, but not entirely, by infusion of L-NMMA. This suggests that hyperglycemia may reduce nitric oxide av... | yes |
9416448 | Do speech perception performance of nucleus multichannel cochlear implant users with partial electrode insertions? | [
"The present investigation examined the speech perception performance of five children with ossified cochleas who received partial insertions of the Nucleus 22-channel cochlear implant.",
"The partial-insertion subjects' preimplant and 1.5 yr postimplant performance on a battery of speech perception tests was com... | The present results suggest that partial insertion of a multichannel implant device is an appropriate and feasible approach to the surgical management and auditory rehabilitation of children with extensive or complete ossification of the cochlea. | yes |
19185865 | Are increased serum levels of methylglyoxal-derived hydroimidazolone-AGE associated with increased cardiovascular disease mortality in nondiabetic women? | [
"To investigate the association of the levels of methylglyoxal-derived hydroimidazolone AGE modified proteins (MG-H1-AGE) with cardiovascular disease (CVD) mortality in an 18-year follow-up study in Finnish nondiabetic and diabetic subjects.",
"The study design was a nested case-control study. Serum MG-H1-AGE lev... | Our 18-year follow-up study shows that high baseline serum levels of MG-H1 type of AGE modified proteins were associated with CVD mortality in nondiabetic women, but not in nondiabetic men or in diabetic subjects. | yes |
24231754 | Is endoglin ( CD105 ) a more appropriate marker than CD31 for detecting microvessels in carotid artery plaques? | [
"Microvascular proliferation is a major risk factor for plaque vulnerability in patients with carotid stenosis. There are several vascular endothelial markers such as CD31 and CD105, but it is unclear which marker is most sensitive for microvessels. This study sought to examine the correlations between CD31 and CD1... | In patients with carotid artery stenosis, CD105 is more appropriate than CD31 for detecting microvessels in carotid plaques. In patients with diabetes mellitus, CD105 is significantly more highly expressed in microvessels than CD31. | yes |
26791940 | Do mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome? | [
"Mitochondrial dysfunction has been hypothesized to occur in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a disease characterized by fatigue, cognitive difficulties, pain, malaise, and exercise intolerance. We investigated whether haplogroup, single nucleotide polymorphisms (SNPs), or heteroplasmy o... | Analysis of mitochondrial genomes in ME/CFS cases indicates that individuals of a certain haplogroup or carrying specific SNPs are more likely to exhibit certain neurological, inflammatory, and/or gastrointestinal symptoms. No increase in susceptibility to ME/CFS of individuals carrying particular mitochondrial genomes... | yes |
22074268 | Does co-morbid diabetes in patients with Crohn 's disease predict a greater need for surgical intervention? | [
"The prevalence of diabetes is increasing rapidly. Given its pro-inflammatory nature, comorbid diabetes may affect the course of Crohn's disease (CD).",
"To determine whether comorbid diabetes influences the natural history of CD.",
"We compared a cohort with CD and comorbid diabetes to a nondiabetic control po... | Co-morbid diabetes in patients with Crohn's disease predicts a greater need for surgical intervention. | yes |
22207561 | Is cD4 count associated with postoperative infection in patients with orthopaedic trauma who are HIV positive? | [
"Since the advent of effective antiretroviral therapy, the number of people with AIDS has increased and a certain percentage of these patients will require emergent orthopaedic surgery. Little is known regarding orthopaedic infections and the association of CD4 counts with postoperative infection in patients with H... | It is evident that patients who are HIV positive with low CD4 counts undergoing emergent orthopaedic intervention are a patient population at risk for infection. Further study is necessary to evaluate preoperative and perioperative interventions that may decrease infections in this population. | yes |
26996563 | Does the Resistance Mechanism and Clonal Distribution of Tigecycline-Nonsusceptible Klebsiella pneumoniae isolate in Korea? | [
"Tigecycline is one of the drugs used to treat multi-drug resistant Klebsiella pneumoniae (K. pneumoniae) infections, including complicated skin and soft tissue infections, complicated intra-abdominal infection, and community-acquired pneumonia in the Republic of Korea. However, since its commercial release, K. pne... | Several dominate clonal types infer tigecycline resistance to K. pneumoniae, including ST11, ST768, ST15, ST23, ST48, and ST307. There does not seem to be a transferrable medium, such as plasmid, for the resistance yet, although mutation of the ramR gene may be a common event, accounting for 48% of the nonsusceptibilit... | yes |
25073061 | Does nADPH oxidase 2 mediate angiotensin II-dependent cellular arrhythmias via PKA and CaMKII? | [
"Angiotensin II (Ang II) signaling has been implicated in cardiac arrhythmogenesis, which involves induction of reactive oxygen species (ROS). It was shown that Ang II can activate Ca/Calmodulin kinase II (CaMKII) by oxidation via a NADPH oxidase 2 (NOX2)-dependent pathway leading to increased arrhythmic afterdepol... | Ang II activates PKA and CaMKII via NOX2, which results in disturbed Na and Ca currents (via PKA) and enhanced diastolic SR Ca leakage (via CaMKII). Oxidative activation of PKA and CaMKII via NOX2 may represent important pro-arrhythmogenic pathways in the setting of increased Ang II stimulation, which may be relevant f... | yes |
18415747 | Does dietary alpha-ketoglutarate reduce gastrectomy-evoked loss of calvaria and trabecular bone in female rats? | [
"Surgical removal of the stomach (gastrectomy, Gx) leads to osteopenia in animals and in humans. In the rat, Gx adversely affects calvaria and trabecular bone. alpha-Ketoglutarate (AKG) is a precursor of hydroxyproline--the most abundant amino acid in bone collagen. The purpose of this study was to investigate the ... | Gx resulted in loss of calvarial, trabecular and cortical bone in the rat. AKG counteracted the effect of Gx on calvaria and trabecular bone but not on cortical bone. | yes |
23108056 | Does implantable cardioverter-defibrillator shock prevention reduce mortality : a systemic review? | [
"Mortality is increased among implantable cardioverter-defibrillator (ICD) recipients who receive shocks; however, whether shocks cause this increase or are simply a marker of risk is unknown. Antiarrhythmic medications, catheter ablation, and enhanced ICD programming all may reduce ICD shocks, but whether shock re... | There is no compelling evidence that existing interventions that reduce ICD shocks significantly improve survival. | no |
23867999 | Is deleterious BRCA1/2 mutation an independent risk factor for carboplatin hypersensitivity reactions? | [
"We tested the hypothesis that BRCA1/2 mutation carriers with ovarian cancer are at higher risk of carboplatin hypersensitivity reactions (HSRs).",
"Medical records of women enrolled in two carboplatin+olaparib clinical trials (NCT01237067/NCT01445418) were reviewed. A maximum of eight cycles containing carboplat... | Deleterious BRCA1/2 mutation increased susceptibility and shortened time to carboplatin HSR, independently of other reported factors. These data suggest that at-risk women should be counselled regarding likelihood, symptoms, and potential earlier onset of carboplatin HSRs. | yes |
22494552 | Is the development of agoraphobia associated with the symptoms and location of a patient 's first panic attack? | [
"The place where a patient experiences his/her first panic attack (FPA) may be related to their agoraphobia later in life. However, no investigations have been done into the clinical features according to the place where the FPA was experienced. In particular, there is an absence of detailed research examining pati... | The results of this study suggest that the clinical features of panic disorder patients vary according to the place of their FPA. The at-home group patients experienced "fear of dying" more frequently and felt more distress during their FPA than did the subjects in the other groups. These results indicate that patients... | yes |
27778641 | Is progesterone resistance in endometriosis modulated by the altered expression of microRNA-29c and FKBP4? | [
"Endometriosis results in aberrant gene expression in the eutopic endometrium(EuE) and subsequent progesterone(P) resistance. MicroRNA(miR) microarray data in a baboon model of endometriosis showed an increased expression of miR-29c.",
"To explore the role of miR-29c in P resistance in a subset of women with endo... | We demonstrate that miR-29c expression is increased in EuE of baboons and women with endometriosis which might contribute to a compromised P response by diminishing the levels of FKBP4. Resection of DIE likely to reverse the P resistance associated with endometriosis in women. | yes |
20544712 | Does selective depletion of peripheral granulocyte/monocyte enhance the efficacy of scheduled maintenance infliximab in Crohn 's disease? | [
"This is the first report on a case of Crohn's disease (CD), who was successfully maintained with a combination of infliximab (IFX) and selective depletion of granulocytes/monocytes by adsorption (GMA).",
"A 33-year-old female with CD activity index (CDAI) 294.2 responded to iv IFX (5mg/kg) administered at weeks ... | IFX appears to induce and maintain remission of CD, but it may lose its efficacy after repeated administration. GMA is safe and by selectively depleting elevated/activated leukocytes may be a useful adjunct for IFX efficacy. | yes |
15241103 | Does ventilation strategy affect cytokine release after mesenteric ischemia-reperfusion in rats? | [
"To evaluate the impact of different ventilation modalities on lung and plasma concentrations of cytokines in a model of secondary lung inflammation, mesenteric ischemia-reperfusion, in rats.",
"Prospective, randomized, controlled animal study.",
"Research laboratory of a university.",
"Sixty-four male adult ... | This study shows that an injurious ventilation does not produce significant in vivo release of cytokines in intact animals but promotes the release of pro- and anti-inflammatory cytokines in an inflammatory context. | yes |
27735035 | Is low expression of miR-409-3p a prognostic marker for breast cancer? | [
"The present study aimed to clarify the expression pattern and prognostic role of miR-409-3p in breast cancer patients.",
"miR-409-3p levels in breast cancer tissues were tested by qRT-PCR. The chi-square test and Fishers exact tests were used to examine the associations between miR-409-3p expression and the clin... | Our results revealed that miR-409-3p was related to the prognosis of patients with breast cancer and might be a promising predictor of miR-409-3p recurrence. | yes |
20044634 | Does claudin-5 overexpression correlate with aggressive behavior in serous ovarian adenocarcinoma? | [
"Claudins are essential tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, and are responsible for the permeability of the paracellular space. The expression of claudin-5 and its correlation to ovarian cancer behavior was investigasted.",
"A total of 85 serous ovarian cancer ... | Increased claudin-5 expression is associated with aggressive behavior in serous ovarian adenocarcinoma. | yes |
15145000 | Do automatic connector devices for proximal anastomoses decrease embolic debris compared with conventional anastomoses in CABG? | [
"Emboli generated during cardiac surgery have been associated with aortic clamping and manipulation. Proximal anastomotic devices are thought to be less traumatic by eliminating partial clamping, potentially resulting in fewer adverse outcomes. Intra-aortic filtration has been shown to effectively capture particula... | The application of proximal aortic connectors without partial clamping does not reduce particulate emboli or affect clinical outcomes compared with conventional anastomoses. Cross-clamping during cardiopulmonary bypass produces less particulate debris than conventional or automated proximal anastomoses performed off-pu... | no |
21553143 | Does butylidenephthalide suppress human telomerase reverse transcriptase ( TERT ) in human glioblastomas? | [
"Telomerase is widely expressed in most human cancers, but is almost undetectable in normal somatic cells and is therefore a potential drug target. Using the human telomerase promoter platform, the naturally occurring compound butylidenephthalide (BP) was selected for subsequent investigation of antitumor activity ... | These findings suggest that BP inhibits proliferation and induces senescence in human glioblastomas by downregulating hTERT expression and consequently telomerase activity. This is the first study to describe regulation of telomerase activity by BP in human glioblastomas. | yes |
25040118 | Is positive school climate associated with lower body mass index percentile among urban preadolescents? | [
"Schools are an important environmental context in children's lives and are part of the complex web of factors that contribute to childhood obesity. Increasingly, attention has been placed on the importance of school climate (connectedness, academic standards, engagement, and student autonomy) as 1 domain of school... | Positive school climate is associated with lower student BMI percentile. More research is needed to understand the mechanisms behind this relationship and to explore whether interventions promoting positive school climate can effectively prevent and/or reduce obesity. | yes |
16943891 | Is p wave dispersion increased in pulmonary stenosis? | [
"The right atrium pressure load is increased in pulmonary stenosis (PS) that is a congenital anomaly and this changes the electrophysiological characteristics of the atria. However, there is not enough data on the issue of P wave dispersion (PWD) in PS.",
"Forty-two patients diagnosed as having valvular PS with e... | P wave dispersion and p max are increased in PS. While PWD was correlated with the pressure gradient that is the degree of narrowing, it was not correlated with the diameters of the right and left atria. | yes |
17980225 | Does social support predict hemodynamic recovery from mental stress in patients with implanted defibrillators? | [
"Emotionally stressful events appear to trigger malignant ventricular arrhythmias and myocardial infarction in cardiac patients. However, the physiological pathways linking psychological stress to arrhythmias and adverse disease outcomes remain incompletely understood. In patients with implanted cardioverter-defibr... | Our data indicate that in ICD patients better perceived social support is associated with a more pronounced hemodynamic recovery after mental stress. | yes |
22399238 | Is the dopaminergic stabilizer pridopidine to a major extent N-depropylated by CYP2D6 in humans? | [
"The influence of the cytochrome P450 enzyme CYP2D6 in the metabolism of the novel dopaminergic stabilizer pridopidine was investigated in healthy Swedish Caucasians.",
"Six extensive metabolizers (EM) and six poor metabolizers (PM) of debrisoquine were given a single oral dose of pridopidine (EM, 50 mg; PM, 25 m... | Following a single dose of pridopidine, the drug is N-depropylated by CYP2D6 in EM, while in PM the most important elimination pathway is renal glomerular filtration. Results of studies examining the effects of multiple repeat dosing suggest that the CYP2D6 enzyme is at least partly inactivated by pridopidine. | yes |
22226967 | Is liver kinase B1 expression ( LKB1 ) repressed by estrogen receptor alpha ( ERα ) in MCF-7 human breast cancer cells? | [
"Liver kinase 1 (LKB1) is emerging as a multifunctional protein, acting as a key metabolic enzyme, regulator of cell polarity, and transcription factor. Altered LKB1 expression has been linked with various cancers and may be a potential prognostic marker. While the functional role of LKB1 continues to undergo inten... | ERα repressively modulates the expression of LKB1 at the transcriptional level. Targeting the expression of LKB1 by modulating ERα signaling may provide a potential approach to further evaluate its function in ERα-positive breast cancers. | yes |
11682575 | Does glucagon-like peptide-1 ( 7-37 ) augment insulin-mediated glucose uptake in elderly patients with diabetes? | [
"Glucagon-like peptide-1 (GLP-1) is an intestinal insulinotropic hormone that augments glucose-induced insulin secretion in patients with type 2 diabetes. It has also been proposed that a substantial component of the glucose-lowering effects of GLP-1 occurs because this hormone enhances insulin-mediated glucose dis... | We conclude that GLP-1 may enhance insulin sensitivity in elderly patients with diabetes. | yes |
23621545 | Is viscous impedance an important indicator of abnormal esophageal motility? | [
"Non-obstructive Dysphagia (NOD) is one of the most common symptoms evaluated using esophageal manometry. Although manometry is considered the gold standard, many NOD patients have normal evaluations. Esophageal function testing with combined multichannel intraluminal impedance and esophageal manometry (MII-EM) is ... | Our data support our belief that a normal liquid manometry with an abnormal viscous impedance analysis in a patient with NOD indicates abnormal esophageal motility. Therefore, viscous impedance should be performed on all patients during the evaluation of NOD. | yes |
19330352 | Is expression of anion exchanger 1 associated with tumor progress in human gastric cancer? | [
"Anion exchanger 1 (AE1) is a transmembrane glycoprotein which is abundantly expressed in erythrocyte plasma membrane and mediates the electroneutral exchange of Cl(-) and HCO(3) (-). We previously reported that the AE1 protein was unexpectedly expressed in the gastric and colonic cancer and take part in the carcin... | The results showed a strong association of AE1 expression with the onset and progression of the gastric cancer and that may be helpful for improving the tumor classification and the treatment of cancer. | yes |
15501202 | Does educational disadvantage impair functional recovery after hospitalization in older persons? | [
"To determine whether low educational level is associated with poor functional recovery after hospitalization in older adults.",
"We followed 862 patients (374 with low education, defined as <high school) for 6 months after hospitalization. Poor functional recovery was defined as an Activities of Daily Living sco... | Educational disadvantage impairs functional recovery after hospitalization in older persons. | yes |
27383822 | Does urban Telemedicine enable Equity in Access to Acute Illness Care? | [
"Children with care for acute illness available through the Health-e-Access telemedicine model at childcare and schools were previously found to have 22% less emergency department (ED) use than counterparts without this service, but they also had 24% greater acute care use overall.",
"We assessed the hypothesis t... | At baseline, overall acute illness utilization of suburban children exceeded that of inner-city children. Overall utilization for inner-city children increased with telemedicine to that of suburban children at baseline. Without telemedicine, however, inner-city use remained substantially less than for suburban counterp... | yes |
18815589 | Is a paucimorphic variant in the HMG-CoA reductase gene associated with lipid-lowering response to statin treatment in diabetes : a GoDARTS study? | [
"Considerable interindividual variation exists in cholesterol-lowering response to 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors (statins). HMGCR catalyzes the rate-limiting step in cholesterol biosynthesis, and also plays a significant role in cholesterol homeostasis. We evaluated the associat... | Individuals heterozygous for the G allele of rs17238540 in the HMGCR gene may respond less well to statin therapy in terms of total cholesterol and triglyceride lowering. | yes |
27064202 | Does panel testing reveal nonsense and missense CDH1 mutations in families without hereditary diffuse gastric cancer? | [
"The reported penetrance of germline CDH1 mutations is high in families with hereditary diffuse gastric cancer (HDGC). Men and women have a 70% and 56%, respectively, cumulative risk of developing diffuse gastric cancer by age 80. Women additionally have a 42% cumulative risk of developing breast cancer. Due to the... | Our study demonstrates the need for further analysis of CDH1 mutation penetrance in order to better counsel asymptomatic CDH1 mutation carriers on preventative measures and general care. | yes |
20152272 | Is lesion size a major determinant of the mammographic features of ductal carcinoma in situ : findings from the Sloane project? | [
"To assess the radiological features of calcific ductal carcinoma in situ (DCIS) in a large, multicentre dataset according to grade and size, and to investigate the possibility that DCIS has different mammographic features when small.",
"The dataset consisted of all Sloane Project DCIS cases where calcification w... | Lesion size has a strong influence on the radiological features of calcific DCIS; small, high-grade lesions often show no casting calcifications, whereas casting calcifications are seen in nearly half of large, low-grade lesions. As small clusters of punctate or granular calcifications may represent high-grade DCIS, an... | yes |
25599038 | Does early gonadotropin-releasing hormone antagonist start improve follicular synchronization and pregnancy outcome as compared to the conventional antagonist protocol? | [
"To assess whether an early GnRH antagonist start leads to better follicular synchronization and an improved clinical pregnancy rate (CPR).",
"A retrospective cohort study. A total of 218 infertile women who underwent IVF between January 2011 and February 2013. The initial cohort (Cohort I) that underwent IVF bet... | The modified early antagonist start protocol may improve the mature oocyte yield, possibly via enhanced follicular synchronization, while resulting in superior CPR as compared to the conventional antagonist protocol, which needs to be studied further in prospective randomized controlled trials. | yes |
20113495 | Does a peptidyl-glucosamine derivative affect IKKalpha kinase activity in human chondrocytes? | [
"Nuclear factor-kappaB (NF-kappaB) transcription factor regulates several cell signaling pathways, such as differentiation and inflammation, which are both altered in osteoarthritis. Inhibitor kappaB kinase (IKK)alpha and IKKbeta are kinases involved in the activation of the NF-kappaB transcription factor. The aim ... | Our results demonstrate that glucosamine and its peptidyl derivative can interfere with NF-kappaB signaling pathway by inhibiting IKKalpha activity in human chondrocytes. However, the mechanism of action of the two molecules is not completely overlapping. While NAPA can both specifically inhibit the IKKalpha kinase act... | yes |
26992380 | Does intra-articular injection of mono-iodoacetate induce osteoarthritis of the hip in rats? | [
"The mechanism for hip pain has been unclear because of a lack of experimental animal models. We aimed to establish an intra-articular injection technique to the rat hip and to document the effect of intra-articular mono-iodoacetate (MIA) injection to the rat hip with radiography and histology.",
"Using 60 6-week... | We established an intra-articular injection technique to the rat hip, creating a hip OA model in the rat by intra-articular injection of MIA. | yes |
16962108 | Does a selective cyclooxygenase-2 inhibitor suppress the growth of endometriosis xenografts via antiangiogenic activity in severe combined immunodeficiency mice? | [
"To investigate the effects of a selective cyclooxygenase (COX)-2 inhibitor on endometriosis xenografts in immunodeficient mice.",
"Prospective placebo-controlled study.",
"An academic facility at a Japanese university graduate school of medicine.",
"Eight human ovarian endometriomas from seven patients.",
... | Selective COX-2 inhibitors decreased the size of implants and effectively treated endometriosis. | yes |
12147023 | Does a rabbit model for monitoring in vivo viability of human platelet concentrate using flow cytometry? | [
"Viability in vivo of novel platelet components cannot be readily determined in human transfusions. Elaboration of valid animal models may be useful for this purpose.",
"Viability of platelet concentrates (PCs) WBC reduced before storage was determined by flow cytometry in rabbits whose reticuloendothelial system... | The rabbit model elaborated is sufficiently sensitive to reveal differences in human platelet viability in vivo between conventional and cold-damaged PCs. It may be useful for comparing viability of different platelet components that cannot be readily tested in human transfusions. | yes |
16208612 | Do different tilting disc valves show similar rotation-dependent impairment in hemodynamic performance under a tilted implantation position? | [
"Aortic annulus calcification can promote tilted implantation of mechanical valves. This study evaluates the hemodynamics of tilting disc valves under this condition.",
"23 mm and 25 mm Ultracor (UC) and Medtronic-Hall-Easy-Fit (MH) valves were investigated in a pulse-duplicator under physiological conditions. Me... | Tilting worsened systolic performance regardless of valve type. It should therefore be avoided. Due to extensive regurgitation at 0 degrees rotation, this position should be corrected whenever tilting is inevitable. | yes |
22858735 | Does accuracy of Timed Up and Go Test for screening risk of fall among community-dwelling elderly? | [
"To determine the accuracy of the Timed Up and Go Test (TUGT) for screening the risk of falls among community-dwelling elderly individuals.",
"This is a prospective cohort study with a randomly by lots without reposition sample stratified by proportional partition in relation to gender involving 63 community-dwel... | The TUGT proved to be an accurate measure for screening the risk of falls among elderly individuals. Although different from that reported in the international literature, the 12.47 second cutoff point seems to be a better predictive value for Brazilian elderly individuals. | yes |
26208856 | Is cdc7 overexpression an independent prognostic marker and a potential therapeutic target in colorectal cancer? | [
"Cdc7 is a widely expressed protein kinase implicated in cell division, cell cycle checkpoint mechanisms and cancer progression. Recently, it has been suggested as a target for anti-cancer therapy.",
"To determine the relationship of Cdc7 protein expression with tumor phenotype, molecular features and prognosis, ... | Our data show that Cdc7 is highly expressed in CRC and a potential therapeutic target in a subset of cancers with high p53 expression. Moreover, our findings strongly argue for a clinical utility of Cdc7 immunostaining as an independent prognostic biomarker in colorectal cancer enabling to select patients for adjuvant ... | yes |
25428165 | Do some Strychnos spinosa ( Loganiaceae ) leaf extracts and fractions have good antimicrobial activities and low cytotoxicities? | [
"Strychnos spinosa Lam. is a deciduous tree used in traditional medicine to treat infectious diseases. This study is designed to determine the antimicrobial, antioxidant and cytotoxic activities of extracts and fractions from leaves of S. spinosa.",
"Extracts were obtained by maceration with acetone, methanol and... | The acetone extract and the chloroform fraction had the highest antibacterial activity. By solvent-solvent fractionation it was possible to increase the activity against A. fumigatus and to decrease the cytotoxicity leading to a potentially useful product to protect animals against aspergillosis. Our results therefore ... | yes |
24749562 | Does eGR1 support the osteogenic differentiation of dental stem cells? | [
"To evaluate whether and how the transcription factor early growth response gene 1 (EGR1) affects the osteogenic differentiation of dental stem cells.",
"Dental stem cells from apical papilla (SCAPs) and from the dental follicle (DFCs) were transfected with EGR1-specific siRNA or EGR-1 expression plasmid. Gene re... | EGR1 supported the osteogenic differentiation of dental stem cells by potentially regulating the expression of DLX3 and BMP2. | yes |
27614355 | Does length of FMR1 repeat alleles within the normal range substantially affect the risk of early menopause? | [
"Is the length of FMR1 repeat alleles within the normal range associated with the risk of early menopause?"
] | The length of repeat alleles within the normal range does not substantially affect risk of early menopause. | no |
14963271 | Does glucose but not lactate in combination with acidosis aggravate ischemic neuronal death in vitro? | [
"Hyperglycemia aggravates brain damage in clinical stroke and in experimental in vivo models of cerebral ischemia. Elevated preischemic glucose levels, lactate production, and intracerebral acidosis correlate with increased brain damage. We have developed a murine hippocampal slice culture model of in vitro ischemi... | Aggravation of brain damage by hyperglycemia in vivo can be reproduced in hippocampal slice cultures in vitro. Our results demonstrate that glucose per se, but not lactate, in combination with acidosis mediates the detrimental hyperglycemic effect through a mechanism independent of ionotropic glutamate receptors. | yes |
25809873 | Does nedd4 E3 ubiquitin ligase promote cell proliferation and autophagy? | [
"Nedd4 (neural precursor cell expressed developmentally down-regulated protein 4) is a member of the HECT E3 ubiquitin ligases, and is elevated in prostate, bladder and colorectal cancers, and promotes colonic cell population expansion. Up to now, molecular mechanisms of how Nedd4 functions, have not been well unde... | Our results indicate that expression of Nedd4 promoted cell proliferation and colony formation but prevented apoptosis. Moreover, Nedd4 promoted autophagy and was associated with the mTOR signalling pathway. | yes |
20103054 | Does glaucoma surgery decrease the rates of localized and global visual field progression? | [
"Incisional glaucoma surgical procedures produce greater intraocular pressure (IOP) reduction and less IOP variability than medical treatment. We sought to determine the efficacy of glaucoma surgery in decreasing localized and global rates of visual field (VF) progression.",
"Retrospective, interventional case se... | Successful IOP reduction after glaucoma surgery greatly reduces both the number of progressing points and the localized and general rates of VF progression. | yes |
18922527 | Is functional LCAT required for macrophage cholesterol efflux to human serum? | [
"To evaluate the capacity of serum from carriers of LCAT gene mutations to promote cell cholesterol efflux through the ABCA1, ABCG1, and SR-BI pathways.",
"Serum was obtained from 41 carriers of mutant LCAT alleles (14 carriers of two mutant LCAT alleles and 27 heterozygotes) and 10 non-carrier relatives (control... | Serum from carriers of LCAT gene mutations has the same capacity of control serum to decrease the cholesterol content of cholesterol-loaded macrophages due to a greater cholesterol efflux capacity via ABCA1. | no |
10728212 | Is loss of CO2 reactivity of cerebral blood flow associated with severe brain damage in mechanically ventilated very low birth weight infants? | [
"Early detection of pathophysiological factors associated with permanent and severe brain damage in preterm infants requiring intensive care is a major issue in neonatal neurology. The aim of this study was to investigate if an abnormal CO2 reactivity of cerebral blood flow in high risk very low birth weight infant... | In mechanically ventilated very low birthweight infants low CO2 reactivity of cerebral blood flow (below 10%/kPa CO2) during the first 36 hours of life was associated with poor neurodevelopmental outcome or hypoxic-ischaemic encephalopathy at autopsy. Loss of CO2 reactivity may play a role in the pathogenesis of hypoxi... | yes |
24189625 | Does the transcription factor HoxB5 stimulate vascular remodelling in a cytokine-dependent manner? | [
"Proper blood vessel formation is essential in health and is often dysregulated in ischaemic diseases. Therefore, regulatory mechanisms that control angiogenesis and arteriogenesis are required to improve treatment of ischaemic diseases. The aim of this study was to investigate the role of homeobox transcription fa... | Our data suggest that overexpression of HoxB5 enhances blood vessel perfusion in vivo by up-regulation of MCP-1 and IL-6 as well as in enhanced leucocyte infiltration and blood vessel remodelling. | yes |
27327028 | Does exercise Training prevent Diaphragm Contractile Dysfunction in Heart Failure? | [
"Patient studies have demonstrated the efficacy of exercise training in attenuating respiratory muscle weakness in chronic heart failure (HF), yet direct assessment of muscle fiber contractile function together with data on the underlying intracellular mechanisms remains elusive. The present study, therefore, used ... | Our findings demonstrate that AET can protect against diaphragm contractile fiber dysfunction induced by HF, but it remains unclear whether alterations in oxidative stress and/or protein degradation are primarily responsible. | yes |
22438068 | Are loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 associated with tumor progression and survival in colorectal carcinoma? | [
"Genomewide expression profiling has identified a number of genes differentially expressed in colorectal carcinomas (CRCs) compared to normal tissue. Some of these genes were linked to epithelial-mesenchymal transition. We tested whether genes including desmocollins and homeobox genes were distinct on the protein l... | Reduced expression of PITX1 was independently correlated to shorter patients survival and could serve as a prognostic marker. Decreased expression of DSC1-3 is significantly correlated with higher tumor grading. Downregulation of DSC1 could be explained by DNA hypermethylation in colon cancer cells. | yes |
21237166 | Is the epithelial barrier maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding? | [
"Tumor necrosis factor (TNF) increases intestinal epithelial cell shedding and apoptosis, potentially challenging the barrier between the gastrointestinal lumen and internal tissues. We investigated the mechanism of tight junction remodeling and barrier maintenance as well as the roles of cytoskeletal regulatory mo... | Maintenance of the epithelial barrier during TNF-induced cell shedding is a complex process that involves integration of microtubules, microfilaments, and membrane traffic to remove apoptotic cells. This process is accompanied by redistribution of apical junctional complex proteins to form intercellular barriers betwee... | yes |
24314262 | Does multicolor banding remain an important adjunct to array CGH and conventional karyotyping? | [
"Array comparative genomic hybridization (CGH) for high resolution detection of chromosome imbalance, and karyotype analysis using G-banded chromosomes for detection of chromosome rearrangements, provide a powerful diagnostic armoury for clinical cytogenetics. However, abnormalities detected by karyotype analysis c... | Despite the recent advance of array CGH in molecular cytogenetics we conclude that fluorescence in situ hybridization, including MCB, is still required for the elucidation of structural chromosome rearrangements, and remains an essential adjunct in modern diagnostic laboratories. | yes |
8090467 | Is diagnostic management by gatekeepers cost effective for neuro-ophthalmology? | [
"To determine whether the \"gatekeeper physician system\" for evaluating neuro-ophthalmologic problems is cost effective.",
"The authors retrospectively reviewed the records of 588 patients referred for neuro-ophthalmologic evaluation between July and December 1989 to determine the frequency and cost of unnecessa... | The gatekeeper system managed by primary care physicians for these four neuro-ophthalmologic problems not only did not conserve healthcare dollars but also had a negative impact on cost control. For neuro-ophthalmologic disorders, prompt subspecialty evaluation and examination appear to be a cost-effective strategy. | no |
20629848 | Do substantial skin disorders in psychiatric illness coincide with diabetes and addiction? | [
"Dermatological diseases in psychiatric patients are common; however, epidemiological data on this subject are scarce and to our knowledge integral studies of dermatological disease in psychiatric inpatients are not available yet.",
"The aim of this study was to describe the incidence of dermatological problems i... | Dermatological problems are common in hospitalized psychiatric patients. Patients with diabetes mellitus are at high risk for skin infections. There are significant relationships between the psychiatric and the dermatological diagnoses. The length of the admission to a psychiatric hospital does not seem to play a major... | yes |
22742859 | Is nFKB1-94ATTG ins/del polymorphism ( rs28362491 ) associated with cardiovascular disease in patients with rheumatoid arthritis? | [
"Rheumatoid arthritis (RA) is an inflammatory disease associated with increased cardiovascular (CV) mortality. A recent study has disclosed association between NFKB1-94ATTG ins/del polymorphism and higher risk of coronary heart disease in healthy Caucasians. Because of that, we assessed the influence of this polymo... | Our results suggest that NFKB1-94ATTG ins/del polymorphism is associated with CV disease in patients with RA. | yes |
21041810 | Is dairy products consumption associated with decreased levels of inflammatory markers related to cardiovascular disease in apparently healthy adults : the ATTICA study? | [
"The aim of this work was to investigate the association between consumption of dairy products and levels of various inflammatory markers among adults with no evidence of cardiovascular or other chronic disease.",
"The ATTICA study is a cross-sectional survey that enrolled 1514 men (18-87 years old) and 1528 wome... | We identified an inverse association between dairy products consumption and levels of various inflammatory markers among healthy adults. Additional clinical trials are needed to refute or confirm our findings. | yes |
12677805 | Do [ Preliminary study about therapeutical contact lenses use ]? | [
"The goal of the paper is to emphasize the advantages of the application of therapeutical contact lenses as compared to the eye patch.",
"There have been taken into study 42 patients-43 eyes, to whom we applied therapeutical contact lenses.",
"In the studied cases there have been taken into discussion the type ... | 1. The wearing of therapeutical contact lens determined the improvement of the pain, of the eye discomfort and the corneal epithelium healing. 2. A therapeutical alternative clearly superior to the occlusive eye patch, the therapeutical contact lens limits the indications of tarsorrhaphy and conjunctival flap. 3. The t... | yes |
26643984 | Do sFRP1 variations influence susceptibility and immune response to Mycobacterium tuberculosis in a Chinese Han population? | [
"SFRP1 acts as a well-established inhibitory regulator of the Wnt signaling pathway, whose polymorphisms have been demonstrated to be associated with the risk of inflammation, infection as well as cancer. We verified the hypothesis that single nucleotide polymorphisms (SNPs) within SFRP1 gene are associated with su... | SNPs rs4736958 and rs7832767 of SFRP1 gene were significantly associated with tuberculosis susceptibility and might influence the expression levels of inflammatory markers of tuberculosis patients in a Chinese Han population. | yes |
25495800 | Does spatial localization of the first and last enzymes effectively connect active metabolic pathways in bacteria? | [
"Although much is understood about the enzymatic cascades that underlie cellular biosynthesis, comparatively little is known about the rules that determine their cellular organization. We performed a detailed analysis of the localization of E.coli GFP-tagged enzymes for cells growing exponentially.",
"We found th... | We conclude that active biochemical pathways inside the cytoplasm are organized spatially following a rule where their first or their last enzymes localize to effectively connect the different active pathways and thus could reflect the activity state of the cell's metabolic network. | yes |
9473092 | Does infant pediatric liver transplantation result equal those for older pediatric patients? | [
"From July 1984 to July 1995, 99 pediatric patients underwent 127 orthotopic liver transplants (OLT) at the University of Wisconsin Children's Hospital. The patients were divided into four groups according to age at time of transplant: group I, 0 to 6 months (n = 20); group II, 6 to 12 months (n = 18); group III, 1... | These results demonstrate that OLT can be effectively performed on infants of all ages and that OLT should not be delayed because of age. | yes |
25805939 | Does high neutrophil-lymphocyte ratio indicate poor prognosis for acute-on-chronic liver failure after liver transplantation? | [
"To investigate the significance of pre-transplant neutrophil-lymphocyte ratio (NLR) in determining the prognosis of liver transplant (LT) recipients with acute-on-chronic liver failure (ACLF).",
"Data were collected from the liver transplantation data bank. The NLR values and other conventional inflammatory mark... | A high NLR is a convenient and available predictor for prognosis of LT patients and can potentially optimize the current criteria for LT in ACLF. | yes |
21593291 | Is impaired fasting glucose associated with renal hyperfiltration in the general population? | [
"Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IF... | Borderline hyperglycemia was associated with hyperfiltration, whereas hyperinsulinemia was not. Longitudinal studies are needed to investigate whether the hyperfiltration associated with IFG is a risk factor for renal injury in the general population. | yes |
25371129 | Does protein expression profiling predict graft performance in clinical ex vivo lung perfusion? | [
"To study the impact of ex vivo lung perfusion (EVLP) on cytokines, chemokines, and growth factors and their correlation with graft performance either during perfusion or after transplantation.",
"EVLP is a modern technique that preserves lungs on normothermia in a metabolically active state. The identification o... | Perfusate protein expression during EVLP can differentiate lungs with good outcome from lungs PGD3 after transplantation. These perfusate biomarkers can be potentially used for more precise donor lung selection improving the outcomes of transplantation. | yes |
9539876 | Does human monocyte-endothelial cell interaction induce platelet-derived growth factor expression? | [
"The purpose of this study was to investigate whether the synthesis of platelet-derived growth factor (PDGF), a major mitogen and chemoattractant for vascular smooth muscle cells, was induced by the direct cell-to-cell interaction between human monocytes and umbilical vein endothelial cells (ECs).",
"PDGF protein... | These results indicate that the direct cell-to-cell interaction between human monocytes and ECs induces PDGF synthesis in both types of cells, suggesting that PDGF produced locally by monocyte-EC adhesive interaction plays an important role in the pathogenesis of atherosclerosis by promoting the migration and accumulat... | yes |
21887731 | Do enterotoxin-producing staphylococci cause intestinal inflammation by a combination of direct epithelial cytopathy and superantigen-mediated T-cell activation? | [
"Enterotoxin-producing Staphylococcus aureus may cause severe inflammatory intestinal disease, particularly in infants or immunodeficient or elderly patients. They are also recognized to be associated with sudden infant death syndrome. Little is known, however, about mucosal responses to staphylococci.",
"The muc... | Staphylococci induce enterocolitis by a combination of direct enterocyte cytopathy mediated by EDIN toxins, disrupting the epithelial barrier, and enterotoxin superantigen-induced mucosal T-cell activation. Gut epithelial production of β-defensins may contribute to host defense against invasive staphylococcal disease. | yes |
19593994 | Does [ Alternating magnetic field damage the reproductive function of murine testes ]? | [
"To explore the relationship between physical and biological effects of alternating magnetic field and study the influence of the magnetic field on the reproductive function of murine testes.",
"Thirty ICR mice were randomized into 5 groups: normal control, X-ray radiation, weak magnetic field (1000 Hz), 1 h stro... | Magnetic field, either strong or weak, may damage the testis function by inducing injury to seminiferous tubules and Leydig cells, thickening of the basal membrane, derangement, exfoliation, massive apoptosis and necrosis of spermatogenic cells in the lumen, situation of the epididymis, and consequently the absence of ... | yes |
1443004 | Does acute intrauterine hypoxia increase amniotic fluid prostaglandin F metabolites in the pregnant sheep? | [
"Amniotic fluid infection promotes cytokine release, prostaglandin production, and premature labor. In several tissues local hypoxia also activates the secretion of cytokines. Many patients initially seen in premature labor carry small-for-gestational-age fetuses, a condition associated with intrauterine hypoxia. T... | We speculate that the prostaglandin increase in amniotic fluid in response to intrauterine hypoxia could eventually lead to premature labor. Whether the increase in prostaglandins is mediated by changes in cytokines is unknown at the present time. | yes |
9609409 | Does ibuprofen impair renal function in patients undergoing infrarenal aortic surgery with epidural anaesthesia? | [
"To investigate the effect of preoperative ibuprofen administration on renal function during and after infrarenal aortic surgery under thoracolumbar epidural anaesthesia (EPA).",
"A prospective randomised, double-blinded clinical study.",
"Operation room and intensive care unit in a university hospital.",
"Tw... | The inhibition of endogenous prostaglandin release by ibuprofen does not substantially impair renal function during infrarenal aortic surgery under EPA. | no |
26013707 | Does prior Innominate Vein Occlusion Preclude Successful Bidirectional Superior Cavopulmonary Connection? | [
"Low superior vena cava (SVC) blood flow has recently been identified as a marker for bidirectional superior cavopulmonary connection (SCPC) failure and death. Prior innominate vein occlusion is considered a significant anatomic risk factor for SCPC failure. We therefore evaluated the outcomes of infants who underw... | Although patients with prior upper-body venous obstruction may have lower systemic oxygen saturations at hospital discharge, they do not demonstrate an increased SCPC failure or mortality rate. Innominate vein occlusion or its equivalent in patients with bilateral SVCs should not preclude the performance of SCPC. Physi... | no |
23313468 | Does characteristics of infections associated with external ventricular drain of cerebrospinal fluid? | [
"Manifestations of external ventricular drain (EVD) - associated infections overlap with those of the underlying neurosurgical conditions. We analyzed characteristics of EVD-associated infections.",
"We included patients aged ≥18 years with EVD-associated infections from 1997 to 2008, using modified CDC criteria ... | Fever and increased CSF leukocytes should raise the suspicion of EVD-associated infection, which may occur up to 10 days after removal of EVD. | yes |
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