id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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23686775 | Does moderate-intensity single exercise session induce renal damage? | [
"The aim of this study was to determine whether a single moderate-intensity exercise session induces renal injury based on various parameters that reflect kidney dysfunction, including urinary L-type fatty acid-binding protein (L-FABP).",
"Adult outpatients (n = 31) with chronic kidney disease (CKD) not receiving... | A single session of moderate-intensity exercise was not associated with an increase in renal parameters used to assess renal damage. | no |
21801168 | Does focal resection of fast ripples on extraoperative intracranial EEG improve seizure outcome in pediatric epilepsy? | [
"High-frequency oscillations (HFOs), termed ripples at 80-200 Hz and fast ripples (FRs) at >200/250 Hz, recorded by intracranial electroencephalography (EEG), may be a valuable surrogate marker for the localization of the epileptogenic zone. We evaluated the relationship of the resection of focal brain regions cont... | The interictal high-rate FRs are a possible surrogate marker of the epileptogenic zone. Interictal ripples are not as specific a marker of the epileptogenic zone as interictal FRs. Resection of the brain regions with high-rate interictal FRs in addition to the SOZ may achieve a better seizure outcome. | yes |
21492950 | Does inhibition of ceramide synthesis reverse endothelial dysfunction and atherosclerosis in streptozotocin-induced diabetic rats? | [
"To explore the effect of myriocin on EDVD and atherosclerosis in diabetic rats.",
"Rats were fed with a high-fat/high-sucrose/high-cholesterol diet (20% sucrose, 10% animal oil, 1.0% bile salt and 2.5% cholesterol) (hereinafter defined as diabetic groups) or Purina Rodent Chow (NC group), the former was interven... | After treated with myriocin, the EDVD in diabetic rats has been improved by increasing PI3K/PKB/eNOS phosphorylation and NO release, and meanwhile the atherosclerosis has reversed. | yes |
8956851 | Is cerebellar hypometabolism in focal epilepsy related to age of onset and drug intoxication? | [
"We wished to investigate the cerebellar depression of regional cerebral glucose metabolism (rCMRGlu) in patients with focal epilepsy.",
"In 170 consecutive patients with medically refractory, focal epilepsy the rCMRGlu was measured in cerebellum and brain.",
"rCMRGlu was markedly decreased in both cerebellar h... | Our retrospective study suggests that the cerebellum is particularly vulnerable in infancy to ongoing epileptic activity and high dosage of antiepileptic drugs (AEDs). | yes |
23551894 | Do high levels of FOXP3⁺ regulatory T cells in gastric MALT lymphoma predict responsiveness to Helicobacter pylori eradication? | [
"Although Helicobacter pylori eradication is a first-line treatment of gastric MALT lymphoma, roughly 25% of patients do not respond to treatment. CD4⁺ FOXP3⁺ regulatory T (Treg) cells regulate immune responses in physiological conditions and various inflammatory conditions, including H. pylori-associated diseases.... | A high number of Treg cells or a high ratio of Treg cells to the total number of CD4⁺ T cells in gastric MALT lymphoma could predict responsiveness to eradication therapy. | yes |
24890150 | Is prostasin gene polymorphism at rs12597511 associated with severe preeclampsia in Chinese Han women? | [
"Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease associated with shallow invasion of trophoblast cells and inadequate spiral artery remodeling. Trophoblast and tumor cells have similar invasion mechanism. Prostasin is closely related to tumor development, invasion and metast... | The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia. | yes |
9704791 | Is multifetal pregnancy reduction associated with an increased risk of intrauterine growth restriction , except for very-high-order multiples? | [
"Our purpose was to investigate whether multifetal pregnancies reduced to twins have an increased risk of intrauterine growth restriction and discordant birth weight.",
"This retrospective cohort study investigated the rates of birth weight discordance > 20% and intrauterine growth restriction using both twin and... | This study suggests that multifetal pregnancy reduction is not associated with an increased risk of intrauterine growth restriction unless the starting fetal number is > or = 5. This finding provides a further rationale to avoid transferring excessive numbers of preembryos after in vitro fertilization. | no |
11208684 | Is `` Stable '' ventricular tachycardia a benign rhythm : insights from the antiarrhythmics versus implantable defibrillators ( AVID ) registry? | [
"Sustained ventricular tachycardia (VT) can be unstable, can be associated with serious symptoms, or can be stable and relatively free of symptoms. Patients with unstable VT are at high risk for sudden death and are best treated with an implantable defibrillator. The prognosis of patients with stable VT is controve... | Sustained VT without serious symptoms or hemodynamic compromise is associated with a high mortality rate and may be a marker for a substrate capable of producing a more malignant arrhythmia. Implantable cardioverter-defibrillator therapy may be indicated in patients presenting with stable VT. | no |
11591345 | Does structure of a conjugating enzyme-ubiquitin thiolester intermediate reveal a novel role for the ubiquitin tail? | [
"Ubiquitin-conjugating enzymes (E2s) are central enzymes involved in ubiquitin-mediated protein degradation. During this process, ubiquitin (Ub) and the E2 protein form an unstable E2-Ub thiolester intermediate prior to the transfer of ubiquitin to an E3-ligase protein and the labeling of a substrate for degradatio... | Complementary surfaces were found on the E2 and Ub proteins whereby the C terminus of Ub wraps around the E2 protein terminating in the thiolester between C88 (Ubc1(Delta450)) and G76 (Ub). The model supports in vivo and in vitro experiments of E2 derivatives carrying surface residue substitutions. Furthermore, the mod... | yes |
12115232 | Is apoptotic U1-70 kd antigenically distinct from the intact form of the U1-70-kd molecule? | [
"To determine whether immune responses to an apoptotically modified form of a human lupus autoantigen can be distinguished from immune responses to the intact form of the same antigen.",
"Immunoblot and enzyme-linked immunosorbent assay techniques were used to test human autoimmune sera for the presence of antibo... | The apoptotic form of U1-70 kd displays B cell epitopes that are not displayed on the intact form of U1-70 kd. Caspase cleavage in the absence of additional posttranslational modifications is sufficient to induce the display of some of these epitopes. Immunity to apoptotically modified proteins can develop against casp... | yes |
22417481 | Does effect of annatto seed and coriander leave as natural antioxidants in fish meatballs during frozen storage? | [
"The effects of annatto (0.1 g/100g) and coriander (0.5 g/100g) were assessed against lipid oxidation in white hake meatballs cooked in boiling water (95 ± 1 °C) for 30 min and stored at -18 °C for 120 d. The fatty acids (FA) and the nutritional quality, cholesterol, cholesterol oxides, thiobarbituric acid reactive... | Spices, especially coriander and annatto, can be an alternative to substitute synthetic additives with antioxidants to prevent loss of important unsaturated fatty acids (UFA) in fish meatballs during frozen storage for 120 d. The maximum effect was observed when 0.5% coriander and 0.1% annatto were used in combination.... | yes |
22874590 | Do mAP optimization as a predictor of cochlear implant outcomes in children with narrow internal auditory canal? | [
"The purposes of this study were to investigate the auditory performance and MAP characteristics of implanted children with narrow internal auditory canal (IAC), and to examine the clinical usefulness of MAP optimization as a predictor of their cochlear implant (CI) outcomes by analyzing their auditory performance ... | MAP optimization had a predictable value in determining the postoperative performance of children with narrow IAC who received a CI. The most suitable habilitation method can be determined early after implantation by identifying the presence of MAP optimization. | yes |
17596134 | Does high expression reduce an antibody response after neonatal gene therapy with B domain-deleted human factor VIII in mice? | [
"Gene therapy could prevent bleeding in patients with hemophilia A, but might induce antibodies that block factor VIII (FVIII) function.",
"To test the efficacy of gene therapy in the newborn period for preventing a response to human FVIII (hFVIII) because of immaturity of the immune system.",
"Varying doses of... | Injection of a high RV dose [10(10) transducing units (TU) kg(-1)] into newborn hemophilia A or C3H mice resulted in 61% and 13% of normal hFVIII antigen in plasma, respectively; most mice did not produce anti-hFVIII antibodies, and hemophilia A mice did not bleed. Furthermore, most mice with >20 ng mL(-1) of hFVIII in... | yes |
23351078 | Do iL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1 and B2 receptors through a STAT6-dependent mechanism? | [
"Bone resorption induced by interleukin-1β (IL-1β) and tumour necrosis factor (TNF-α) is synergistically potentiated by kinins, partially due to enhanced kinin receptor expression. Inflammation-induced bone resorption can be impaired by IL-4 and IL-13. The aim was to investigate if expression of B1 and B2 kinin rec... | These data show, for the first time, that IL-4 and IL-13 decrease kinin receptors in a STAT6-dependent mechanism, which can be one important mechanism by which these cytokines exert their anti-inflammatory effects and impair bone resorption. | yes |
22841784 | Does genome-wide association study identify variants associated with progression of liver fibrosis from HCV infection? | [
"Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fib... | Our GWA study identified several susceptibility loci for HCV-induced liver fibrosis; these were linked to genes that regulate apoptosis. Apoptotic control might therefore be involved in liver fibrosis. | yes |
9702436 | Are hydroperoxides in plasma reduced by intensified insulin treatment . A randomized controlled study of IDDM patients with microalbuminuria? | [
"An association between reactive oxygen species and diabetic micro- and macrovascular complications has been proposed. In the present study, we have examined the effect of an improved blood glucose control on plasma levels of hydroperoxides in patients with IDDM.",
"Subjects included 30 young IDDM patients with m... | This study provides support for the hypothesis that hyperglycemia is an important factor in the generation of hydroperoxides, and, thus, reactive oxygen species, in the circulation of IDDM patients. | yes |
23800083 | Does mapping IS6110 in high-copy number Mycobacterium tuberculosis strains show specific insertion points in the Beijing genotype? | [
"Mycobacterium tuberculosis Beijing strains are characterized by a large number of IS6110 copies, suggesting the potential implication of this element in the virulence and capacity for rapid dissemination characteristic of this family. This work studies the insetion points of IS6110 in high-copy clinical isolates s... | This work presents a detailed analysis of locations of IS6110 in high-copy clinical isolates, showing points of insertion present with high frequency in the Beijing family and absent in other strains. | yes |
24847332 | Does calcification of the aortic arch predict cardiovascular and all-cause mortality in chronic hemodialysis patients? | [
"Cardiovascular calcification represents a marker of cardiovascular risk in chronic dialysis patients. In the general population, aortic arch calcification (AAC) can predict cardiovascular mortality. We conducted a prospective study to investigate factors associated with AAC in hemodialysis patients and examined it... | Calcification of the aortic arch detected in plain chest radiography was an important determinant of cardiovascular as well as all-cause mortality in chronic hemodialysis patients. The presence and severity of AAC predicted long-term survival. | yes |
20864513 | Does virtual optimization of nasal insulin therapy predict immunization frequency to be crucial for diabetes protection? | [
"Development of antigen-specific strategies to treat or prevent type 1 diabetes has been slow and difficult because of the lack of experimental tools and defined biomarkers that account for the underlying therapeutic mechanisms.",
"The type 1 diabetes PhysioLab platform, a large-scale mathematical model of diseas... | Here, the advantage of applying computer modeling in optimizing the therapeutic efficacy of nasal insulin immunotherapy was confirmed. In silico modeling was able to streamline the experimental design and to identify the particular time frame at which biomarkers associated with protection in live NODs were induced. The... | yes |
27566678 | Does heritability and factors associated with number of harness race start in the Spanish Trotter horse population? | [
"Longevity/durability is a relevant trait in racehorses. Genetic analysis and knowledge of factors that influence number of harness race starts would be advantageous for both horse welfare and the equine industry.",
"To perform a genetic analysis on harness racing using number of races as a measure of longevity/d... | Horses' total number of harness race starts is a promising tool for genetic analysis and the evaluation of racing longevity and durability. The estimated heritability provides evidence to support the application of genetic selection of total career number of races to improve longevity/durability of STH. | yes |
27252421 | Does plasma miR-26a as a Diagnostic Biomarker regulate Cytokine Expression in Systemic Juvenile Idiopathic Arthritis? | [
"We sought to identify specific microRNA (miRNA) for systemic juvenile idiopathic arthritis (sJIA) and to determine the involvement of these miRNA in regulating the expression of cytokines.",
"Microarray profiling was performed to identify differentially expressed miRNA in sJIA plasma. Levels of candidate miRNA a... | This study demonstrates that miR-26a is expressed specifically and highly in sJIA plasma and suggests that miR-26a may regulate the levels of cytokines in sJIA. Our findings highlight miR-26a as a potential biomarker for the diagnosis as well as differential diagnosis of sJIA. | yes |
10413643 | Does low-frequency component of body surface potential maps identify patients at risk for ventricular tachycardia? | [
"To investigate the ability of spectral features of signal-averaged body-surface potential maps in identifying post-infarction patients who are at risk of developing ventricular tachycardia.",
"We recorded 120 lead body surface potential maps during sinus rhythm in 135 subjects (45 patients with healed myocardial... | Our results suggest that the bulk of diagnostic information associated with arrhythmogenicity resides in the low-frequency band of the power spectrum. This finding is at variance with the established notion that only the high-frequency component of signal-averaged electrocardiograms carries such information. | yes |
27283399 | Is osteopontin elevated in patients with mitral annulus calcification independent from classic cardiovascular risk factors? | [
"Osteopontin (OPN) regulates the Ca(++)-deposition in bone and coronary arteries. Elevated OPN were also associated with (aortic) valve calcification in healthy individuals. This study aimed to investigate the association between OPN levels and mitral annulus calcification (MAC) in patients with coronary artery dis... | This is the first clinical trial which observed increased circulating OPN levels in MAC, suggesting a distinct role of OPN in the process of MAC. Considering the current knowledge about OPN it is more likely that OPN does not promote but counteracts valve calcification and therefore is elevated in course of a calcifica... | yes |
27252916 | Does application of Predictive Nursing reduce Psychiatric Complications in ICU Patients after Neurosurgery? | [
"Our aim was to investigate the effects of clinical application of perioperative predictive nursing on reducing psychiatric complications in Intensive Care Unit (ICU) patients after neurosurgery.",
"A total of 129 patients who underwent neurosurgery and received intensive care were enrolled in our study from Febr... | Application of predictive nursing on ICU patients who undergo neurosurgery could effectively reduce the incidence of psychiatric symptoms as well as other adverse events. Our study provided clinical evidences to encourage predictive nursing in routine settings for patients in critical conditions. | yes |
24703461 | Do children with spinal abnormalities have an increased health burden from upper tract urolithiasis? | [
"To examine the epidemiology and health care burden of upper tract urolithiasis in children with spinal abnormalities using a large, national database. Children with spinal dysraphism are predisposed to urolithiasis for many reasons, including immobility, bacteriuria, and urinary stasis. No large epidemiologic stud... | Children with spinal curvature and spinal dysraphism have a much greater rate of upper tract urolithiasis, resulting in more procedures and related costs. Urolithiasis represents a significant, chronic health burden for children with spinal abnormalities. Screening and preventive care may reduce the impact of urolithia... | yes |
23715760 | Does identification of drug-related problems by a clinical pharmacist in addition to computerized alert? | [
"Both clinical pharmacists and computerized physician order entry systems with clinical decision support (CPOE/CDSS) can reduce drug-related problems (DRPs). However, the contribution of a clinical pharmacist in addition to CPOE/CDSS has not been established in a prospective study.",
"To determine which DRPs can ... | As most DRPs identified by a clinical pharmacist were not detected in daily clinical practice by CPOE/CDSS, a clinical pharmacist contributes to reducing DRPs. The sensitivity of CPOE/CDSS to detect certain classes of problems should be optimized. | yes |
19298258 | Is inhibition of inducible NO synthase , cyclooxygenase-2 and interleukin-1beta by torilin mediated by mitogen-activated protein kinases in microglial BV2 cells? | [
"Traditionally, the stem and root bark of Ulmus davidiana var. japonica (Ulmaceae) have been known to be anti-inflammatory in Korea. Anti-inflammatory effects of torilin, isolated from this plant and the underlying mechanisms were examined by using lipopolysaccharide (LPS)-stimulated microglial BV2 cells.",
"The ... | This study indicates that torilin inhibited LPS-induced iNOS, COX-2 and IL-1beta via down-regulation of ERK1/2, p38 MAPK, NF-kappaB and CREB and suggests that torilin has a potential as an anti-inflammatory drug candidate. | yes |
23921963 | Is expression of MUC4 mucin observed mainly in the intestinal type of intraductal papillary mucinous neoplasm of the pancreas? | [
"This study aimed to examine expression profile of MUC4 in intraductal papillary mucinous neoplasm of the pancreas (IPMN).",
"We performed immunohistochemistry (IHC) of MUC4 in 142 IPMNs, with evaluation of the specificity of 2 anti-MUC4 monoclonal antibodies, 8G7 and 1G8, in cancer cell lines.",
"Monoclonal an... | A significantly higher expression of MUC4 in intestinal-type IPMNs than in gastric-type IPMNs will be one of the biomarkers to discriminate between the intestinal-type IPMNs with high malignancy potential from gastric-type IPMNs with low malignancy potential. | yes |
16988507 | Does low-dose oxaliplatin enhance the antitumor efficacy of paclitaxel in human gastric cancer cell lines? | [
"The enhanced antitumor effect of paclitaxel when used with oxaliplatin in gastric cancer is reported, however the underlying biological mechanism is unknown.",
"We tested the cytotoxic activity, apoptosis, and mitotic catastrophe of paclitaxel and oxaliplatin in MKN-28 and MKN-45 gastric cancer cell lines. The m... | Our findings suggest that the mechanism of enhanced cytotoxicity might be through enhanced mitotic catastrophe and apoptosis, which is possibly due to chemotherapy-induced downregulation of surviving. The combination of paclitaxel and low-dose oxaliplatin should be incorporated into the design of a clinical trial. | yes |
15196281 | Does mechanical strain enhance proteoglycan message in fibroblasts from asthmatic subjects? | [
"Remodelling of the asthmatic airway includes increased deposition of proteoglycan (PG) molecules. One of the stimuli driving airway remodelling may be excessive mechanical stimulation.",
"We hypothesized that fibroblasts from asthmatic patients would respond to excessive mechanical strain with up-regulation of m... | These data support the hypothesis that proteoglycan message is increased in asthmatic fibroblasts subject to mechanical strain. This finding has implications for the mechanisms governing airway wall remodelling in asthma. | yes |
24495004 | Are endothelial markers associated with thrombolysis resistance in acute stroke patients? | [
"The endothelium is crucial in maintaining the haemostatic balance between pro- and anti-thrombotic factors. In this pilot study, the association of endothelial biomarkers with arterial recanalization and clinical outcome in the setting of acute ischaemic stroke (AIS) was evaluated amongst patients treated with rec... | Recanalization after thrombolytic therapy is associated with low sTM and sEPCR levels but not with vWF levels. If corroborated in further larger studies, these findings could be helpful in the identification of patients resistant to rt-PA thrombolysis who could benefit from a modified recanalization therapy. | yes |
24613022 | Are rectal microRNAs perturbed in pediatric inflammatory bowel disease of the colon? | [
"Changes in intestinal microRNAs have been reported in adult patients with ulcerative colitis or Crohn's disease. The goal of this study was to identify changes in microRNA expression associated with colitis in children with inflammatory bowel disease.",
"Rectal mucosal biopsies (n = 50) and blood samples (n = 47... | This study has demonstrated that rectal and serum microRNAs are perturbed in pediatric inflammatory bowel disease. Future studies identifying targets of inflammatory bowel disease-associated microRNAs may lead to novel therapies. | yes |
25855759 | Are the ever-evolving landscape of candidaemia in patients with acute leukaemia : non-susceptibility to caspofungin and multidrug resistance associated with increased mortality? | [
"The epidemiology and clinical course of candidaemia in patients with acute leukaemia, a population frequently exposed to antifungals, have not been extensively studied. In the present contemporary series of acute leukaemia patients, we describe patient characteristics, Candida species and MIC distributions and inv... | In patients with acute leukaemia, a shift in candidaemia epidemiology was noted with a 99% predominance of non-albicans species. Non-susceptibility of Candida strains to caspofungin or multidrug resistance were independent markers of poor outcome in this patient population. | yes |
25223705 | Is pA/Lateral chest X-ray equivalent to cine-fluoroscopy for the detection of conductor externalization in defibrillation leads? | [
"Riata™ and Riata ST defibrillation leads (St. Jude Medical, Sylmar, CA, USA) are susceptible to insulation defects with conductor externalization. Cine-fluoroscopy is considered to be the gold standard for the documentation of insulation defects, but similar detection rates have been reported for posterior-anterio... | PA/lateral CXR with zooming is equivalent to cine-fluoroscopy for the detection of Riata insulation defects and should be considered as the preferred screening method. | yes |
14971880 | Do bAL levels of interleukin-18 change before or during acute rejection in lungtransplant recipients? | [
"Acute rejection (AR) of the allograft is a major clinical problem after lungtransplantation. Repeated episodes of AR increase the risk of developing obliterative bronchiolitis, the main cause of mortality in this patient group. It is believed that AR is caused by T-lymphocytes reacting to donor antigens and in tur... | We found no changes in IL-18 concentration in BAL associated with AR. IL-18 in BAL did not correlate with BAL lymphocyte percentage. We conclude that change in soluble IL-18 protein does not constitute a useful marker of acute rejection in lung allograft recipients. | no |
15961978 | Is polymorphic organic anion transporting polypeptide 1B1 a major determinant of repaglinide pharmacokinetics? | [
"A large interindividual variability exists in the plasma concentrations of repaglinide. Our aim was to investigate possible associations between the pharmacokinetics of repaglinide and single nucleotide polymorphisms (SNPs) in the genes encoding for the drug transporters organic anion transporting polypeptide 1B1 ... | Genetic polymorphism in SLCO1B1 is a major determinant of interindividual variability in the pharmacokinetics of repaglinide. The effect of SLCO1B1 polymorphism on the pharmacokinetics of repaglinide may be clinically important. | yes |
25450597 | Does alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigate isoflurane-induced cognitive impairment in aged rats? | [
"Postoperative cognitive dysfunction is increasingly recognized as an important clinical syndrome. Inhalation anesthetics are commonly used during surgery, and it has been proposed that inhalation anesthetics impair cognitive function. However, there are few clinical interventions and treatments available to preven... | The study demonstrated that pretreatment with α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates isoflurane-induced learning and memory impairment in aged rats. | yes |
25619399 | Is sox2 the faithful marker for pluripotency in pig : evidence from embryonic studies? | [
"Mammalian first lineage segregation generates trophectoderm (TE) and pluripotent inner cell mass (ICM), which provides an ideal model for studying the mechanisms of maintenance and loss of pluripotency. In mouse, the transcription factor OCT4 restricts to ICM and plays a key role in TE/ICM specification and plurip... | Our results provide a molecular basis in porcine embryonic patterning and a clue for further studying porcine pluripotent regulatory networks. | yes |
25487739 | Is laser capture microdissection a valuable tool in the preoperative molecular screening of follicular lesions of the thyroid : an institutional experience? | [
"The application of molecular tests to thyroid fine needle aspiration (FNA) has been shown to be a valuable tool to better refine the pre-operative malignant risk of patients with indeterminate cytology results. In this study, we investigated the feasibility of using the laser capture microdissection (LCM) techniqu... | LCM is a valuable tool to obtain good quality DNA and RNA for molecular tests in cytological material from thyroid FNA, and can be a useful option in the management of patients with an FN/SFN FNA diagnosis. | yes |
26895520 | Is [ Distraction Osteogenesis an Effective Method to Lengthen Digits in Congenital Malformations ]? | [
"The aim of this study was to investigate the feasible amount of lengthening by distraction osteogenesis in congenital hand deficiencies.",
"A total of 60 patients (1.6-17.8 years) underwent lengthening of 71 bones between 1994 and 2014. Bone lengthening was performed on 46 metacarpals and 25 phalanges. Mostly th... | Metacarpal and phalangeal distraction lengthening is an effective but demanding technique for ray reconstruction in congenital malformations of the hand. It is possible to lengthen a bone by more than 100%. Complications are common, but in most cases easy to handle. | yes |
20353338 | Does histamine protect bone marrow against cellular damage induced by ionising radiation? | [
"Based on our previous data on the histamine radioprotective effect on small intestine, in the present work we aimed to determine whether histamine is able to protect bone marrow cells against ionising radiation damage.",
"56 mice and 40 rats were divided into four groups. Histamine and histamine-irradiated group... | Histamine reduces ionising radiation toxicity on bone marrow cells being a suitable candidate for use as radioprotector, especially for patients undergoing radiotherapy who are at the risk of bone marrow or small intestine damage. | yes |
25062038 | Is serum autotaxin a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis -- a prospective cohort study? | [
"Autotaxin (ATX) and its product lysophosphatidic acid (LPA) are considered to be involved in the development of liver fibrosis and elevated levels of serum ATX have been found in patients with hepatitis C virus associated liver fibrosis. However, the clinical role of systemic ATX in the stages of liver cirrhosis w... | Serum ATX is an indicator for the severity of liver disease and the prognosis of cirrhotic patients. | yes |
12355491 | Do differences in expectations of outcome mediate African American/white patient differences in `` willingness '' to consider joint replacement? | [
"Joint replacement therapy is an effective treatment option for end-stage osteoarthritis (OA) of the knee and/or hip. There are marked racial/ethnic disparities in the utilization of this procedure. The reasons for these disparities are not known. We sought to determine whether African American patients differ from... | African American patients were less likely than white patients to express "willingness" to consider joint replacement if the procedure was needed and recommended. This difference was explained by differences between the groups in their expectations of hospital course, pain, and function following replacement surgery. | yes |
25150637 | Does aKT-mediated enhanced aerobic glycolysis cause acquired radioresistance by human tumor cells? | [
"Cellular radioresistance is a major impediment to effective radiotherapy. Here, we demonstrated that long-term exposure to fractionated radiation conferred acquired radioresistance to tumor cells due to AKT-mediated enhanced aerobic glycolysis.",
"Two human tumor cell lines with acquired radioresistance were est... | Long-term fractionated radiation confers acquired radioresistance to tumor cells by AKT-mediated alterations in their glucose metabolic pathway. Thus, tumor cell metabolic pathway is an attractive target to eliminate radioresistant cells and improve radiotherapy efficacy. | yes |
19586667 | Is transforming growth factor-beta receptor type 1 ( TGFBR1 ) associated with non-syndromic cleft lip with or without cleft palate in patients of Central European descent? | [
"Transforming growth factor-beta (TGF-β) type 1 receptor (also known as activin receptor-like kinase 5, ALK5) is expressed in palatal tissue during embryogenesis. Experimental studies in transgenic mice with a genetic deletion of Alk5 showed that TGF-β type 1 receptor is required for upper lip and midline fusion of... | Despite the ample evidence supporting the role of TGF-β type 1 receptor as a critically important and widespread morphogenetic regulator of craniofacial development in murine models, our results do not support TGFBR1 as major risk factor for NSCL/P in patients of Central European descent. | no |
17614136 | Does type-D personality but not depression predict severity of anxiety in heart failure patients at 1-year follow-up? | [
"Chronic heart failure (CHF) is a debilitating condition associated with poor outcome, including increased anxiety. However, anxiety and its determinants have not yet been studied systematically in CHF. We examined whether type-D personality and depressive symptoms would predict clinically significant anxiety at 1-... | Type-D personality, but not depressive symptoms predicted 1-year clinically significant anxiety. The type-D scale could be used to identify CHF patients at high risk of anxiety, as these patients may be at an increased risk of adverse prognosis and impaired quality of life. | yes |
14981961 | Is the degree of macrophage infiltration into the cancer cell nest a significant predictor of survival in gastric cancer patients? | [
"Tumor-associated macrophages (TAMs) have varying functions depending on the microenvironment of tumor tissue. We studied the biological role of TAMs in gastric cancer on the basis of their spatial distribution in the cancer tissue.",
"Tissue specimens from 84 advanced gastric carcinoma (pT2; 41 cases, pT3; 43 ca... | These results suggested that the aggregation of TAMs within tumor nest had a beneficial effect on host in terms of augmented cytotoxicity and antigen presentation. | yes |
22552110 | Is allergic airway disease unaffected by the absence of IL-4Rα-dependent alternatively activated macrophages? | [
"Markers of alternatively activated macrophages (AAMs) are upregulated in the lungs of asthmatic patients and in mice with allergic airway disease. AAMs are thought to contribute to the pathogenesis of allergic airway disease by virtue of their decreased NO production and increased production of proline and polyami... | Our results suggest that the presence of AAMs in allergic airway disease may be only an association, as a result of the increased T(H)2 responses present during disease, and that IL-4Rα-dependent AAMs do not play an important role in the pathology of disease. | yes |
27648044 | Do impact of admission serum total cholesterol level on in-hospital mortality in patients with acute aortic dissection? | [
"To find out the association between serum total cholesterol (TC) on admission and in-hospital mortality in patients with acute aortic dissection (AAD).",
"From January 2007 to January 2014, we enrolled 1492 consecutive AAD patients with serum TC measured immediately on admission. Baseline characteristics and in-... | Lower serum TC level on admission was strongly associated with higher in-hospital mortality in patients with Type-A AAD. | yes |
25490090 | Does a novel Acute Retroviral Syndrome Severity Score predict the key surrogate markers for HIV-1 disease progression? | [
"Best long-term practice in primary HIV-1 infection (PHI) remains unknown for the individual. A risk-based scoring system associated with surrogate markers of HIV-1 disease progression could be helpful to stratify patients with PHI at highest risk for HIV-1 disease progression.",
"We prospectively enrolled 290 in... | The ARSSS is a simple clinical score that correlates with the best-validated surrogate markers of HIV-1 disease progression. In regions where ART is not universally available and eART is not standard this score may help identifying patients who will profit the most from early antiretroviral therapy. | yes |
8651165 | Does a single intragastric pH electrode accurately measure intragastric acidity? | [
"Recent studies have raised concerns about the validity of using a single intragastric pH electrode to measure gastric acidity accurately and reproducibly. The aim of this study was to compare simultaneous intragastric pH measurements obtained from an indwelling glass pH electrode to those determined by aspirations... | Quantitative evaluations of intragastric acidity (pH) using an intragastric pH electrode and aspiration of gastric juice may yield remarkably different results. Studies that rely on a single intragastric electrode to quantitate intragastric acidity may be highly inaccurate. | no |
19959966 | Does immediate but not long-term administration of nicardipine inhibit tolbutamide-induced insulin secretion from rat pancreatic beta cells? | [
"Calcium channel blockers alter glucose homeostasis, but sufficient data regarding this effect in healthy animals have not been provided. We test the effect of nicardipine on beta cell function in healthy rats.",
"Islets from Sprague-Dawley rats were coincubated with nicardipine, tolbutamide, or their combination... | In healthy rats, immediate administration of nicardipine inhibits insulin secretion of beta cells both in vitro and in vivo but does not exert a deleterious effect in vivo after long-term treatment. | yes |
21574017 | Is psychometric properties and gender invariance of the Chinese version of the self-report Pediatric Quality of Life Inventory version 4.0 : short form acceptable? | [
"To evaluate the psychometric properties and gender invariance of the Chinese version of the Pediatric Quality of Life Inventory (PedsQL) for 8- to 12-year-olds.",
"Psychometric testing and confirmatory factor analysis (CFA) were used with a convenience sample of 8- to 12-year-old children (n = 479) for PedsQL fu... | The Chinese version of the PedsQL is a relatively reliable and valid instrument, and the PedsQL short form showed a better construct validity than did the full form. Measurement across gender was invariant; therefore, the comparisons of quality of life between boys and girls were appropriate. | yes |
22087563 | Are monounsaturated fatty acid , carbohydrate intake , and diabetes status associated with arterial pulse pressure? | [
"Diabetes is a global epidemic. Cardiovascular disease (CVD) is one of the most prevalent consequences of diabetes. Nutrition is considered a modifiable risk factor for CVD, particularly for individuals with diabetes; albeit, there is little consensus on the role of carbohydrates, proteins and fats for arterial hea... | Higher MUFA and carbohydrate intake for persons with diabetes reflecting lower APP may be due to replacement of saturated fats with CHO and MUFA. The associations of APP with diabetes, race and dietary intake need to be confirmed with intervention and prospective studies. Confirmation of these results would suggest tha... | yes |
20610044 | Does andrographolide sensitize Ras-transformed cells to radiation in vitro and in vivo? | [
"Increasing the sensitivity of tumor cells to radiation is a major goal of radiotherapy. The present study investigated the radiosensitizing effects of andrographolide and examined the molecular mechanisms of andrographolide-mediated radiosensitization.",
"An H-ras-transformed rat kidney epithelial (RK3E) cell li... | Andrographolide sensitized Ras-transformed cells to radiation both in vitro and in vivo. Andrographolide-mediated radiosensitization was associated with downregulation of Akt and NF-kappaB activity. These observations indicate that andrographolide is a novel radiosensitizing agent with potential application in cancer r... | yes |
22196836 | Does cognitive therapy improve three-month outcomes in hospitalized patients with heart failure? | [
"Patients with heart failure (HF) experience depressive symptoms that contribute to poorer outcomes. We tested the effects of a brief cognitive therapy intervention on depressive symptoms, negative thinking, health-related quality of life, and cardiac event-free survival.",
"Hospitalized patients with depressive ... | Nurses can deliver a brief intervention to hospitalized patients with heart failure that may improve short-term, event-free survival. Future research is needed to verify these results with a larger sample size. | yes |
15161453 | Does whole-body-vibration training increase knee-extension strength and speed of movement in older women? | [
"To investigate the effects of 24 weeks of whole-body-vibration (WBV) training on knee-extension strength and speed of movement and on counter-movement jump performance in older women.",
"A randomized, controlled trial.",
"Exercise Physiology and Biomechanics Laboratory, Leuven, Belgium.",
"Eighty-nine postme... | WBV is a suitable training method and is as efficient as conventional RES training to improve knee-extension strength and speed of movement and counter-movement jump performance in older women. As previously shown in young women, it is suggested that the strength gain in older women is mainly due to the vibration stimu... | yes |
22385633 | Is pediatric severe asthma characterized by eosinophilia and remodeling without T ( H ) 2 cytokines? | [
"The pathology of pediatric severe therapy-resistant asthma (STRA) is little understood.",
"We hypothesized that STRA in children is characterized by airway eosinophilia and mast cell inflammation and is driven by the T(H)2 cytokines IL-4, IL-5, and IL-13.",
"Sixty-nine children (mean age, 11.8 years; interquar... | STRA in children was characterized by remodeling and variable airway eosinophil counts. However, unlike in adults, there was no neutrophilia, and despite the wide range in eosinophil counts, the T(H)2 mediators that are thought to drive allergic asthma were mostly absent. | yes |
11124597 | Does enalaprilat directly ameliorate in vitro cyclosporin nephrotoxicity in human tubulo-interstitial cells? | [
"Several recent studies have suggested that angiotensin-converting enzyme (ACE) inhibitors ameliorate chronic cyclosporin A (CyA) tubulo-interstitial disease by mechanisms independent of their antihypertensive effects. The aim of the present study was to determine whether ACE inhibition exerts a direct beneficial e... | ACE inhibition directly prevents CyA-induced interstitial fibrosis, but not proximal tubule cytotoxicity, independently of haemodynamic and systemic renin-angiotensin system effects. Renoprotection may be partially afforded by directly preventing the tubular secretion of TGFbeta1. | yes |
25456008 | Is the high-temperature requirement factor A3 ( HtrA3 ) associated with acquisition of the invasive phenotype in oral squamous cell carcinoma cells? | [
"Previous studies have identified several genes involved in the carcinogenesis of oral cancer; however, the detailed mechanisms underlying this process have not been elucidated. Previously, we established a database of the transcriptional progression profile of oral carcinogenesis and identified 15 candidate genes ... | The findings of this study demonstrated that the HtrA3 is likely to be associated with the acquisition of the invasive phenotype in oral squamous cell carcinoma cells and may be a potential prognostic marker for oral cancer. | yes |
26079943 | Does the MUC1 mucin protect against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome? | [
"The mucin MUC1, best known for providing an epithelial barrier, is an important protective host factor in both humans and mice during Helicobacter pylori pathogenesis. This study aimed to identify the long-term consequences of MUC1 deficiency on H. pylori pathogenesis and the mechanism by which MUC1 protects again... | MUC1 is an important, previously unidentified negative regulator of the NLRP3 inflammasome. H. pylori activation of the NLRP3 inflammasome is normally tightly regulated by MUC1, and loss of this critical regulation results in the development of severe pathology. | yes |
27431492 | Does aT-101 enhance gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations? | [
"Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have become the standard care of patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC), development of acquired resistance is inevitable. A secondary mutation of threonine 790 (T790M) is associated with approximately h... | AT-101 enhances gefitinib sensitivity in NSCLC with EGFR T790M mutations. The addition of AT-101 to gefitinib is a promising strategy to overcome EGFR TKIs resistance in NSCLC with EGFR T790M mutations. | yes |
22109977 | Is duration of balloon inflation for optimal stent deployment : five seconds enough? | [
"To assess the effect of the duration of stent inflation on stent expansion using digital stent enhancement (DSE).",
"Optimal stent expansion and apposition to the vessel wall are of critical importance to optimize the results of percutaneous coronary intervention (PCI). However, it is not known if stent inflatio... | The duration of stent balloon inflation has a significant impact on stent expansion. Stent deployment for >25 sec is recommended. | no |
22415236 | Is the synergistic interaction of MEK and PI3K inhibitors modulated by mTOR inhibition? | [
"Combined targeting of MAPK and PI3K signalling pathways may be necessary for optimal therapeutic activity in cancer. This study evaluated the MEK inhibitors AZD6244 and PD0325901, alone and in combination with the dual mTOR/PI3K inhibitor NVP-BEZ235 or the PI3K inhibitor GDC-0941, in three colorectal cancer cell l... | These studies confirm that dual targeting of PI3K and MEK can induce synergistic growth inhibition; however, the combination of specific PI3K inhibitors, rather than dual mTOR/PI3K inhibitors, with MEK inhibitors results in greater synergy. | yes |
11179984 | Does curing Helicobacter pylori infection in patients with duodenal ulcer provoke gastroesophageal reflux disease? | [
"It has been suggested that the incidence of gastroesophageal reflux disease (GERD) increases after successful eradication of Helicobacter pylori infection. We present data on development of GERD from a controlled study of H. pylori eradication in 165 duodenal ulcer patients.",
"Patients (mean age, 55 years; 102 ... | Our data show that successful eradication of H. pylori infection does not increase the incidence of GERD in duodenal ulcer patients. | no |
20173759 | Does long-term ethanol exposure inhibit glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes? | [
"The roles of AMP-activated protein kinase (AMPK) and myocyte enhancer factor 2 isoforms (MEF2A, D) as mediators of the effects of ethanol on glucose transporter 4 (GLUT4) expression are unclear. We studied the effects of ethanol in adipocytes in vivo and in vitro.",
"Thirty-six male Wistar rats were divided into... | The AMPK/MEF2/GLUT4 pathway exists in both rat and human adipocytes, and activated AMPK may positively regulate MEF2 and GLUT4 expression. Ethanol inhibition of this pathway leads to decreased GLUT4 expression, thus reducing insulin sensitivity and glucose tolerance. | yes |
11134190 | Does adjuvant clodronate treatment reduce the frequency of skeletal metastases in node-positive breast cancer patients : 5-year results of a randomized controlled trial? | [
"Bisphosphonates have effectively reduced the development and progression of bone metastases in advanced breast cancer. The aim of this study was to determine whether bone metastases could be prevented by adjuvant clodronate treatment in patients with primary breast cancer.",
"Between 1990 and 1993, 299 women wit... | Adjuvant clodronate treatment does not prevent the development of bone metastases in node-positive breast cancer patients. However, clodronate seems to have a negative effect on DFS by increasing the development of nonskeletal metastases. | no |
20937062 | Is high-affinity immunoglobulin E receptor expression increased in large and small airways in fatal asthma? | [
"IgE and its high-affinity receptor FcɛRI play an important role in allergy and asthma. The distribution of FcɛRI expression in the airways and within the airway wall, however, is largely unknown.",
"In this study, we aimed to map the distribution of FcɛRI in different layers of large airways (LA) and small airwa... | Our results show that the expression of FcɛRI is higher in both LA and SA in FA compared with CTR. These differences are predominantly found in the outer layer where they can be attributed in part to the increased mast cell numbers. These results indicate an increased capacity to mount IgE-mediated reactions in FA, bot... | yes |
22316211 | Are cervical cancer cell lines expressing NKG2D-ligands able to down-modulate the NKG2D receptor on NKL cells with functional implications? | [
"Cervical cancer represents the third most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths in women worldwide. Natural killer (NK) cells play an important role in the defense against viruses, intracellular bacteria and tumors. NKG2D, an activating receptor on NK cells, recognizes MHC... | Our results suggest that differential expression of NKG2D-ligands in cervical cancer cell lines might be associated with the down-modulation of NKG2D, as well as with changes in the cytotoxic activity of NKL cells after cell-cell contact with the tumor cells. | yes |
20378855 | Do atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation? | [
"The extracellular matrix protein fibronectin (FN) is focally deposited in regions of atherosclerosis, where it contributes to inflammatory signaling.",
"To elucidate the mechanism by which FN deposition is regulated by local shear stress patterns, its dependence on platelet-endothelial cell adhesion molecule (PE... | These results indicate that FN gene expression and assembly into matrix fibrils is induced by atheroprone fluid shear stress. This effect is mediated at least in part by the transcription factor NF-kappaB. Additionally, because FN promotes activation of NF-kappaB, atheroprone shear stress creates a positive feedback to... | yes |
17272761 | Are lacunar infarcts the main correlate with cognitive dysfunction in CADASIL? | [
"Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy is caused by mutations in the NOTCH3 gene and is clinically characterized by recurrent stroke and cognitive decline. Previous studies have shown an association between white matter hyperintensities on brain MRI and cognitive... | Lacunar infarct lesion load is the most important MRI parameter associated with cognitive dysfunction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. | yes |
21690572 | Does class III β-tubulin in advanced NSCLC of adenocarcinoma subtype predict superior outcome in a randomized trial? | [
"Platinum-based doublets are the cornerstone of treatment in advanced non-small-cell lung cancer (NSCLC) and often include vinorelbine or taxanes. A predictive biomarker is greatly needed to select chemotherapy-sensitive patients for these microtubule-interfering agents. Class III β-tubulin (TUBB3) has been shown o... | TUBB3 was of predictive value in adenocarcinoma patients in the largest, randomized advanced NSCLC population published to date. It may be clinically useful in conjunction with other biomarkers, but QOL information should be recorded during validation, as prophylactic intervention may be needed in specific subgroups at... | yes |
25885340 | Are cancers of unknown primary origin ( CUP ) characterized by chromosomal instability ( CIN ) compared to metastasis of know origin? | [
"Cancers of unknown primary (CUPs) constitute ~5% of all cancers. The tumors have an aggressive biological and clinical behavior. The aim of the present study has been to uncover whether CUPs exhibit distinct molecular features compared to metastases of known origin.",
"Employing genome wide transcriptome analysi... | CIN may account for the uncommon clinical presentation, chemoresistance and poor outcome in patients with CUP and warrant selective diagnostic strategies and treatment. | yes |
18952695 | Is perivascular adipose tissue-derived visfatin a vascular smooth muscle cell growth factor : role of nicotinamide mononucleotide? | [
"Perivascular adipose tissue (PVAT) inhibits vascular smooth muscle cell (VSMC) contraction and stimulates VSMC proliferation by releasing protein factors. The present study was to determine whether visfatin is involved in these paracrine actions of PVAT, and if so, to explore the underlying mechanisms.",
"Visfat... | Visfatin stimulates VSMC proliferation via NMN-mediated ERK1/2 and p38 signalling. The present study provides a molecular link of visfatin to the paracrine action of PVAT, demonstrates a novel function of visfatin in promoting VSMC proliferation, and reveals NMN as a novel signalling molecule that triggers the prolifer... | yes |
25466953 | Does tomato juice consumption improve blood antioxidative biomarkers in overweight and obese females? | [
"A few studies reported the beneficial effects of tomato juice on oxidative stress status. However, supporting data in obese subjects is scarce. This study aimed to determine the effects of tomato juice consumption on erythrocyte antioxidant enzymes, namely, superoxide dismutase (SOD), glutathione peroxidase (GPx) ... | Our results suggest that tomato juice reduces oxidative stress in overweight (and possibly obese) females and, therefore, may prevent from obesity related diseases and promote health. | yes |
20856884 | Does bacterial flagellin trigger cardiac innate immune responses and acute contractile dysfunction? | [
"Myocardial contractile failure in septic shock may develop following direct interactions, within the heart itself, between molecular motifs released by pathogens and their specific receptors, notably those belonging to the toll-like receptor (TLR) family. Here, we determined the ability of bacterial flagellin, the... | These results are the first to indicate that flagellin has the ability to trigger cardiac innate immune responses and to acutely depress myocardial contractility. | yes |
24627668 | Does hPV DNA and Pap smear test result in cases with and without cervical pathology? | [
"The aim of the study was to determine the HPV prevalance and its relation to Pap smear, colposcopy and colposcopy directed biopsy in our region of Eskisehir, Turkey.",
"A total of 615 women who applied to the outpatient clinic between December 2009 and December 2010 constituted our study population. All patients... | HPV positivity in our hospital setting is low which is compatible with other studies in Turkey. In positive HPV cases there is a good correlation between HPV type and positive cervical biopsy results. | yes |
16495699 | Does routine follow-up by magnetic resonance imaging improve detection of resectable local recurrences from colorectal cancer? | [
"To determine if routine follow-up by magnetic resonance imaging (MRI) improves the detection of resectable local recurrences from colorectal cancer.",
"Surgical treatment offers the best prospect of survival for patients with recurrent colorectal cancer. Unfortunately, most cases are often diagnosed at an unrese... | Pelvic surveillance by MRI is not justified as part of the routine follow-up after a curative resection for colorectal cancer and should be reserved for selectively imaging patients with clinical, colonoscopic, and/or biochemical suspicion of recurrent disease. | no |
24935911 | Are abdominal aortic aneurysms with high thrombus signal intensity on magnetic resonance imaging associated with high growth rate? | [
"A layer of intraluminal thrombus is commonly observed in abdominal aortic aneurysms (AAAs). The purpose of this study was to investigate whether AAAs with high thrombus signal intensity (SI) at T1-weighted (T1w) magnetic resonance imaging (MRI) exhibit a faster aneurysm growth rate.",
"This was a prospective fol... | Abdominal aortic aneurysms with high thrombus SI on T1w MR images are associated with higher aneurysm growth rates. | yes |
19073769 | Are variants near MC4R associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people : studies of 14,940 Danes? | [
"Variants downstream of the melanocortin-4 receptor gene (MC4R) have been reported to associate with obesity. We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals.",
... | rs17782313, rs17700633, and rs12970134 near MC4R associate with measures of obesity in Danish individuals. | yes |
22496754 | Does down-regulation of microRNA-26a promote mouse hepatocyte proliferation during liver regeneration? | [
"Inadequate liver regeneration (LR) is still an unsolved problem in major liver resection and small-for-size syndrome post-living donor liver transplantation. A number of microRNAs have been shown to play important roles in cell proliferation. Herein, we investigated the role of miR-26a as a pivotal regulator of he... | MiR-26a plays crucial role in regulating the proliferative phase of LR, probably by repressing expressions of cell cycle proteins CCND2 and CCNE2. The current study reveals a novel miRNA-mediated regulation pattern during the proliferative phase of LR. | yes |
18416609 | Does preapplication of orthodontic forces to the donor teeth affect periodontal healing of transplanted teeth? | [
"To investigate how the preapplication of orthodontic forces to the donor teeth affects the periodontal healing after transplantation.",
"The orthodontic force (1.5 cN) was applied to the maxillary right molars of 6-week-old male Spraque-Dawley rats (n = 21) in the experimental side, and the left side of the same... | These results suggested that the preapplication of orthodontic force to the donor teeth increased the PDL width and eased the extraction, which might decrease root resorption after replantation. | yes |
22683850 | Does hydrogen-rich University of Wisconsin solution attenuate renal cold ischemia-reperfusion injury? | [
"Renal ischemia-reperfusion (I/R) injury is unavoidable in kidney transplantation and frequently influences both short- and long-term allograft survival rates. One of the major events in I/R injury is the generation of cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to display antioxidant proper... | HRUW solution improved graft function and prolonged graft survival compared with simple cold storage using UW solution by protecting tubular epithelial cells from inflammation and apoptosis. Our new method of organ preservation is a groundbreaking, safe, and simple strategy that may be applied in the clinical setting. | yes |
14696657 | Does nitric acid passivation affect in vitro biocompatibility of titanium? | [
"In general, both chemical composition and surface features of implants affect cell response. The aim of this study was to evaluate the effect of titanium (Ti) passivation on the response of rat bone marrow cells, considering cell attachment, cell morphology, cell proliferation, total protein content, alkaline phos... | Although the protocol for passivation used here could interfere with the pattern of ions released from Ti-6Al-4V and cpTi surfaces, the present study did not show any effect of this surface treatment on in vitro biocompatibility of Ti as evaluated by osteoblast attachment, proliferation, and differentiation. | no |
25304135 | Does hIV-1 Vif inhibit G to A hypermutations catalyzed by virus-encapsidated APOBEC3G to maintain HIV-1 infectivity? | [
"HIV-1 viral infectivity factor (Vif) is an essential accessory protein for HIV-1 replication. The predominant function of Vif is to counteract Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G, A3G), a potent host restriction factor that inhibits HIV-1 replication. Vif mediates the prote... | Our data suggest that even packaged A3G is still under the tyranny of Vif. Our work brings to light an additional caveat for any therapy that hopes to exploit the Vif-A3G axis. The ideal strategy would not only enhance A3G viral packaging, but also reduce HIV-1 Vif viral encapsidation. | yes |
15497369 | Does antioxidant supplementation attenuate oxidative stress at high altitude? | [
"Hypobaric hypoxia and heightened metabolic rate increase free radical production.",
"We tested the hypothesis that antioxidant supplementation would reduce oxidative stress associated with increased energy expenditure (negative energy balance) at high altitude (HA 4300 m).",
"For 12 d at sea level (SL), 18 act... | Antioxidant supplementation did not significantly affect markers of oxidative stress associated with increased energy expenditure at HA. | no |
18328667 | Is endogenous heparin activity decreased in peripheral arterial occlusive disease? | [
"Naturally occurring heparin-like activity in the form of endogenous heparin and heparin sulfate proteoglycans has been shown in normal human plasma. Exogenous low-dose heparin improves pain-free walking distance and maximum walking distance in peripheral arterial occlusive disease (PAOD). Is reduced endogenous hep... | Patients with PAOD have reduced endogenous heparin-like activity that correlates with disease severity. | yes |
15352907 | Does azathioprine formulation optimize metabolite profile in inflammatory bowel disease? | [
"Recent studies have suggested that mercaptopurine metabolism is influenced by drug formulation (mercaptopurine vs. azathioprine) and concomitant use of 5-aminosalicylic acid medications.",
"To determine the influence of dose, formulation and 5-aminosalicylic acid use on mercaptopurine metabolism.",
"Metabolite... | (i) Azathioprine may have metabolic benefits by achieving a correlation of dose with 6-tioguanine nucleotides levels and by leading to lower mean 6-methylmercaptopurine levels. (ii) 5-aminosalicylic acid use does not significantly impact 6-tioguanine levels and may lead to higher 6-methylmercaptopurine levels. | yes |
27716441 | Does shock wave-induced ATP release from osteosarcoma U2OS cells promote cellular uptake and cytotoxicity of methotrexate? | [
"Osteosarcoma is the most prevalent primary malignant bone tumor, but treatment is difficult and prognosis remains poor. Recently, large-dose chemotherapy has been shown to improve outcome but this approach can cause many side effects. Minimizing the dose of chemotherapeutic drugs and optimizing their curative effe... | Our results suggest that shock wave treatment promotes methotrexate-induced apoptosis by altering cell membrane permeability in a P2X7 receptor-dependent manner. Shock wave treatment may thus represent a possible adjuvant therapy for osteosarcoma. | yes |
23800644 | Does superoxide constitute a major signal of mitochondrial superoxide flash? | [
"Mitochondrial flashes detected with an N- and C-terminal circularly-permuted yellow fluorescent protein (cpYFP) have been thought to represent transient and quantal bursts of superoxide production under physiological, stressful and pathophysiological conditions. However, the superoxide nature of the cpYFP-flash ha... | These data indicate that all the three types of mitochondrial flashes stem from the common physiological process of bursting superoxide and ensuing H2O2 production in the matrix of single mitochondrion. | yes |
10029620 | Does transcytosis of immunoglobulin A in the mouse enterocyte occur through glycolipid raft- and rab17-containing compartments? | [
"Glycolipid \"rafts\" have been shown to play a role in apical membrane trafficking in the enterocyte. The present study characterized the membrane compartments of the enterocyte involved in transepithelial transport of small intestinal immunoglobulin A (IgA).",
"Immunogold electron microscopy and radioactive lab... | IgA is transcytosed through a raft-containing compartment, most likely the apical endosomes. Our data also support the notion that rab17 is involved in transcytotic membrane traffic. | yes |
20399419 | Does fetal irradiation interfere with adult cognition in the nonhuman primate? | [
"Exposure to x-irradiation in early gestation has been shown to disrupt normal thalamocortical development in the monkey and thereby model one key feature of the neuropathology of schizophrenia. However, the effect of fetal irradiation on cognitive functions that are vulnerable in schizophrenia (e.g., working memor... | Fetal exposure to irradiation resulted in an adult-onset cognitive impairment in the working memory domain that is relevant to understanding the developmental etiology of schizophrenia. | yes |
19834108 | Does jak/STAT signaling pathway regulate nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells? | [
"Oxidative stress mediated by Nox1- and Nox4-based NADPH oxidase (Nox) plays a key role in vascular diseases. The molecular mechanisms involved in the regulation of Nox are not entirely elucidated. Because JAK/STAT regulates many genes linked to inflammation, cell proliferation, and differentiation, we questioned w... | JAK/STAT is a key regulator of Nox1 and Nox4 in human vascular SMCs. Inhibition of JAK/STAT pathway and the consequent Nox-dependent oxidative stress may be an efficient therapeutic strategy to reduce atherogenesis. | yes |
17927446 | Is induction of BIM essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas? | [
"Mutations in the epidermal growth factor receptor (EGFR) gene are associated with increased sensitivity of lung cancers to kinase inhibitors like erlotinib. Mechanisms of cell death that occur after kinase inhibition in these oncogene-dependent tumors have not been well delineated. We sought to improve understandi... | In drug-sensitive EGFR mutant lung cancer cells, induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors. This finding implies that the intrinsic pathway of caspase activation may influence sensitivity and/or resistance of EGFR mutant lung tumor cells to EGFR kinase inhibition. Manipulation of t... | yes |
27118475 | Does gIFT4 fusokine convert leukemic B cells into immune helper cells? | [
"Chronic lymphocytic leukemia (CLL) remains incurable with standard therapy, and is characterized by excessive expansion of monoclonal abnormal mature B cells and more regulatory immune properties of T cell compartment. Thus, developing novel strategies to enhance immune function merits further investigation as a p... | GIFT4 has potent capability to converts primary CLL cells into APC-like immune helper cells that initiate a T cell driven anti-CLL immune response. | yes |
22378480 | Are mismatch repair proteins hMLH1 and hMSH2 differently expressed in the three main subtypes of sporadic renal cell carcinoma? | [
"We studied the role of minor mismatch repair proteins (MMR) human MutL homologue 1 (hMLH1) and human MutS homologue 2 (hMSH2) in the main subtypes of renal cell carcinoma (RCC).",
"Expression of MMR proteins hMLH1 and hMSH2 were investigated in 166 RCC tumors, containing the main subtypes by immunohistochemistry... | MSI and EMAST are rare events in sporadic RCC, whereas diminished MMR protein expression is linked to tumor entity and might contribute to the different biological behavior of the RCC subtypes. | yes |
16377929 | Is polymorphism of methylenetetrahydrofolate reductase gene ( C677T MTHFR ) a confounding factor of the relationship between serum uric acid level and the prevalence of hypertension in Japanese men? | [
"The association between serum uric acid (UA) and the prevalence of hypertension, and the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphism and hypertension remains unclear. The aim of the present study was to investigate whether the C677T MTHFR mutation genotype (VV) is independently as... | The mutation of C677T MTHFR was not independently associated with the prevalence of hypertension or BP levels although serum UA was. Furthermore, the relationship between serum UA and BP was not modulated by the MTHFR mutation in Japanese men. | no |
17672862 | Is a disease management programme for patients with diabetes mellitus associated with improved quality of care within existing budgets? | [
"To assess the impact of a disease management programme for patients with diabetes mellitus (Type 1 and Type 2) on cost-effectiveness, quality of life and patient self-management. By organizing care in accordance with the principles of disease management, it is aimed to increase quality of care within existing budg... | Introduction of a disease management programme for patients with diabetes is associated with improved intermediate outcomes within existing budgets. Further research should focus on long-term cost-effectiveness, including diabetic complications and mortality, in a controlled setting or by using decision-analytic modell... | yes |
25669193 | Does sleep Quality Among Low-Income Young Women in Southeast Texas predict Changes in Perceived Stress Through Hurricane Ike? | [
"To document the time course of perceived stress among women through the period of a natural disaster, to determine the effect of sleep quality on this time course, and to identify risk factors that predict higher levels of perceived stress.",
"Longitudinal study from 2006-2012.",
"Community-based family planni... | Sleep quality after Hurricane Ike, an intense natural disaster producing substantial damage, impacted changes in perceived stress over time. Our findings suggest the possibility that providing victims of disasters with effective interventions to improve sleep quality could help to reduce their perceived stress over tim... | yes |
26122070 | Is analysis of infant cortical synchrony constrained by the number of recording electrodes and the recording montage? | [
"To assess how the recording montage in the neonatal EEG influences the detection of cortical source signals and their phase interactions.",
"Scalp EEG was simulated by forward modeling 20-200 simultaneously active sources covering the cortical surface of a realistic neonatal head model. We assessed systematicall... | Reliability in assessing true neonatal cortical synchrony is directly related to the choice of EEG recording and analysis configurations. Because of the high conductivity of the neonatal skull, the conventional neonatal EEG recordings are spatially far too sparse for pertinent studies, and this loss of information cann... | yes |
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