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{
 "note": "๋ถ€๋ฌธ ์ด๋ฆ„๋งŒ์œผ๋กœ๋Š” ๋ฌด์—‡์„ ์žฌ๋Š”์ง€ ์•Œ ์ˆ˜ ์—†๋‹ค. ํ‘œ์  ๊ธฐํ˜ธ๋Š” ์ด ๋ถ„์•ผ ์‚ฌ๋žŒ์—๊ฒŒ๋งŒ ์ฝํžŒ๋‹ค.",
 "boards": {
  "hERG": {
   "ko": "์‹ฌ์žฅ๋…์„ฑ โ€” ์นผ๋ฅจ์ฑ„๋„ ์ฐจ๋‹จ",
   "en": "Cardiotoxicity โ€” hERG channel block"
  },
  "Solubility": {
   "ko": "์ˆ˜์šฉํ•ด๋„ โ€” ๋ฌผ์— ๋…น๋Š” ์ •๋„",
   "en": "Aqueous solubility"
  },
  "Withdrawal": {
   "ko": "์‹œํŒ ํ›„ ํ‡ด์ถœ ํŒ์ •",
   "en": "Post-marketing withdrawal"
  },
  "Phenotype": {
   "ko": "์„ธํฌ ํ˜•ํƒœ ๋ณ€ํ™” โ€” ๊ตฌ์กฐ๋งŒ ๋ณด๊ณ  ์˜ˆ์ธก",
   "en": "Cell morphology response from structure alone"
  },
  "CYP3A4": {
   "ko": "๋Œ€์‚ฌ ์ €ํ•ด โ€” ์•ฝ๋ฌผ ์ƒํ˜ธ์ž‘์šฉ ์ตœ๋Œ€ ์›์ธ",
   "en": "CYP3A4 inhibition โ€” main cause of drug interaction"
  },
  "CYP2D6": {
   "ko": "๋Œ€์‚ฌ ์ €ํ•ด โ€” ๊ฐœ์ธ์ฐจ๊ฐ€ ํฐ ํšจ์†Œ",
   "en": "CYP2D6 inhibition โ€” highly polymorphic enzyme"
  },
  "CYP2C9": {
   "ko": "๋Œ€์‚ฌ ์ €ํ•ด โ€” ์™€ํŒŒ๋ฆฐ ๊ณ„์—ด",
   "en": "CYP2C9 inhibition โ€” warfarin class"
  },
  "EGFR": {
   "ko": "ํ์•” ํ‘œ์  โ€” ์ƒํ”ผ์„ฑ์žฅ์ธ์ž ์ˆ˜์šฉ์ฒด",
   "en": "Lung cancer target โ€” EGF receptor"
  },
  "JAK2": {
   "ko": "๊ณจ์ˆ˜์ฆ์‹์งˆํ™˜ ํ‘œ์ ",
   "en": "Myeloproliferative disease target"
  },
  "PI3Ka": {
   "ko": "์ข…์–‘ ์‹ ํ˜ธ์ „๋‹ฌ ํ‘œ์ ",
   "en": "Tumour signalling target"
  },
  "FLT3": {
   "ko": "๊ธ‰์„ฑ๊ณจ์ˆ˜๋ฐฑํ˜ˆ๋ณ‘ ํ‘œ์ ",
   "en": "Acute myeloid leukaemia target"
  },
  "VEGFR2": {
   "ko": "ํ˜ˆ๊ด€์‹ ์ƒ ํ‘œ์  โ€” ์ข…์–‘ ํ˜ˆ๊ด€ ์ฐจ๋‹จ",
   "en": "Angiogenesis target"
  },
  "CDK2": {
   "ko": "์„ธํฌ์ฃผ๊ธฐ ํ‘œ์ ",
   "en": "Cell cycle target"
  },
  "HER2": {
   "ko": "์œ ๋ฐฉ์•” ํ‘œ์ ",
   "en": "Breast cancer target"
  },
  "ABL1": {
   "ko": "๋งŒ์„ฑ๊ณจ์ˆ˜๋ฐฑํ˜ˆ๋ณ‘ ํ‘œ์ ",
   "en": "Chronic myeloid leukaemia target"
  },
  "BRAF": {
   "ko": "ํ‘์ƒ‰์ข… ํ‘œ์ ",
   "en": "Melanoma target"
  },
  "KIT": {
   "ko": "์œ„์žฅ๊ด€๊ธฐ์งˆ์ข…์–‘ ํ‘œ์ ",
   "en": "GIST target"
  },
  "ALK": {
   "ko": "ํ์•” ์œตํ•ฉ ํ‘œ์ ",
   "en": "Lung cancer fusion target"
  },
  "AChE": {
   "ko": "์•Œ์ธ ํ•˜์ด๋จธ ํ‘œ์  โ€” ์•„์„ธํ‹ธ์ฝœ๋ฆฐ ๋ถ„ํ•ดํšจ์†Œ",
   "en": "Alzheimer target โ€” acetylcholinesterase"
  },
  "MAOB": {
   "ko": "ํŒŒํ‚จ์Šจ ํ‘œ์  โ€” ๋ชจ๋…ธ์•„๋ฏผ ์‚ฐํ™”ํšจ์†Œ B",
   "en": "Parkinson target โ€” monoamine oxidase B"
  },
  "COX2": {
   "ko": "์†Œ์—ผ์ง„ํ†ต ํ‘œ์ ",
   "en": "Anti-inflammatory target"
  },
  "LogP": {
   "ko": "์นœ์œ ์„ฑ โ€” ๊ธฐ๋ฆ„๊ณผ ๋ฌผ ์‚ฌ์ด ๋ถ„๋ฐฐ",
   "en": "Lipophilicity โ€” octanol/water partition"
  },
  "Caco2": {
   "ko": "์žฅ ํก์ˆ˜ โ€” ์„ธํฌ์ธต ํˆฌ๊ณผ ์†๋„",
   "en": "Intestinal absorption โ€” monolayer permeability"
  },
  "PPB": {
   "ko": "ํ˜ˆ์žฅ๋‹จ๋ฐฑ๊ฒฐํ•ฉ โ€” ์œ ๋ฆฌ ์•ฝ๋ฌผ ๋น„์œจ์„ ์ •ํ•œ๋‹ค",
   "en": "Plasma protein binding โ€” sets the free fraction"
  },
  "Vdss": {
   "ko": "๋ถ„ํฌ์šฉ์  โ€” ์กฐ์ง์œผ๋กœ ์–ผ๋งˆ๋‚˜ ํผ์ง€๋‚˜",
   "en": "Volume of distribution โ€” tissue partitioning"
  },
  "HalfLife": {
   "ko": "๋ฐ˜๊ฐ๊ธฐ โ€” ๋ชธ์— ์–ผ๋งˆ๋‚˜ ๋จธ๋ฌด๋‚˜",
   "en": "Half-life โ€” how long it stays in the body"
  },
  "D2": {
   "ko": "์กฐํ˜„๋ณ‘ยทํŒŒํ‚จ์Šจ ํ‘œ์  โ€” ๋„ํŒŒ๋ฏผ D2",
   "en": "Schizophrenia and Parkinson target โ€” dopamine D2"
  },
  "MuOpioid": {
   "ko": "์ง„ํ†ต ํ‘œ์  โ€” ๋ฎค ์˜คํ”ผ์˜ค์ด๋“œ ์ˆ˜์šฉ์ฒด",
   "en": "Analgesia target โ€” mu opioid receptor"
  },
  "KappaOpioid": {
   "ko": "๋น„์ค‘๋…์„ฑ ์ง„ํ†ต ํ›„๋ณด โ€” ์นดํŒŒ ์˜คํ”ผ์˜ค์ด๋“œ",
   "en": "Non-addictive analgesia โ€” kappa opioid receptor"
  },
  "A2A": {
   "ko": "ํŒŒํ‚จ์Šจยท๋ฉด์—ญํ•ญ์•” ํ‘œ์  โ€” ์•„๋ฐ๋…ธ์‹  A2A",
   "en": "Parkinson and immuno-oncology target โ€” adenosine A2A"
  },
  "HT2A": {
   "ko": "ํ•ญ์ •์‹ ๋ณ‘ ํ‘œ์  โ€” ์„ธ๋กœํ† ๋‹Œ 5-HT2A",
   "en": "Antipsychotic target โ€” serotonin 5-HT2A"
  },
  "CB1": {
   "ko": "์นธ๋‚˜๋น„๋…ธ์ด๋“œ CB1 ์ˆ˜์šฉ์ฒด",
   "en": "Cannabinoid CB1 receptor"
  },
  "Malaria": {
   "ko": "๋ง๋ผ๋ฆฌ์•„ ์›์ถฉ ์‚ฌ๋ฉธ โ€” ์ ํ˜ˆ๊ตฌ๋‚ด ๋‹จ๊ณ„",
   "en": "Malaria parasite kill โ€” blood stage"
  },
  "LD50": {
   "ko": "๊ธ‰์„ฑ๋…์„ฑ โ€” ์น˜์‚ฌ๋Ÿ‰",
   "en": "Acute toxicity โ€” lethal dose"
  },
  "Selectivity": {
   "ko": "์‹ฌ์žฅ ์•ˆ์ „์—ญ โ€” ํ‘œ์  ์„ธ๊ธฐ์™€ hERG ์„ธ๊ธฐ์˜ ์ฐจ์ด",
   "en": "Cardiac safety margin โ€” target potency minus hERG"
  },
  "BACE1": {
   "ko": "์•Œ์ธ ํ•˜์ด๋จธ ํ‘œ์  โ€” ์•„๋ฐ€๋กœ์ด๋“œ ์ƒ์„ฑ ํšจ์†Œ",
   "en": "Alzheimer target โ€” amyloid-producing protease"
  },
  "BRD4": {
   "ko": "์—ํ”ผ์ œ๋„คํ‹ฑ ํ‘œ์  โ€” ์œ ์ „์ž ์ฝ๊ธฐ ์ฐจ๋‹จ",
   "en": "Epigenetic target โ€” BET bromodomain"
  },
  "HDAC1": {
   "ko": "์—ํ”ผ์ œ๋„คํ‹ฑ ํ‘œ์  โ€” ํžˆ์Šคํ†ค ํƒˆ์•„์„ธํ‹ธํ™”",
   "en": "Epigenetic target โ€” histone deacetylase"
  },
  "HIVRT": {
   "ko": "HIV ์—ญ์ „์‚ฌํšจ์†Œ โ€” ํ•ญ๋ฐ”์ด๋Ÿฌ์Šค",
   "en": "HIV reverse transcriptase โ€” antiviral"
  },
  "Nav17": {
   "ko": "๋งŒ์„ฑ ํ†ต์ฆ ํ‘œ์  โ€” ๋น„๋งˆ์•ฝ์„ฑ ์ง„ํ†ต ํ›„๋ณด",
   "en": "Chronic pain target โ€” non-opioid analgesia"
  },
  "ERalpha": {
   "ko": "์œ ๋ฐฉ์•” ํ‘œ์  โ€” ์—์ŠคํŠธ๋กœ๊ฒ ์ˆ˜์šฉ์ฒด",
   "en": "Breast cancer target โ€” estrogen receptor alpha"
  },
  "Thrombin": {
   "ko": "ํ•ญ์‘๊ณ  ํ‘œ์  โ€” ํ˜ˆ์ „ ํ˜•์„ฑ ํšจ์†Œ",
   "en": "Anticoagulant target โ€” thrombin"
  },
  "FactorXa": {
   "ko": "ํ•ญ์‘๊ณ  ํ‘œ์  โ€” ์ œ10์ธ์ž Xa",
   "en": "Anticoagulant target โ€” factor Xa"
  },
  "AR": {
   "ko": "์ „๋ฆฝ์„ ์•” ํ‘œ์  โ€” ์•ˆ๋“œ๋กœ๊ฒ ์ˆ˜์šฉ์ฒด",
   "en": "Prostate cancer target โ€” androgen receptor"
  },
  "HIVPR": {
   "ko": "HIV ํ”„๋กœํ…Œ์•„์ œ โ€” ํ•ญ๋ฐ”์ด๋Ÿฌ์Šค",
   "en": "HIV protease โ€” antiviral"
  },
  "SEpidermidis": {
   "ko": "ํ‘œํ”ผํฌ๋„์ƒ๊ตฌ๊ท  โ€” ์ „์„ธํฌ ํŒ์ •",
   "en": "S. epidermidis โ€” whole-cell readout"
  },
  "MTB": {
   "ko": "๊ฒฐํ•ต๊ท  โ€” ํ‘œ์ค€๊ท ์ฃผ H37Rv ์ „์„ธํฌ ํŒ์ •",
   "en": "M. tuberculosis H37Rv โ€” whole-cell readout"
  },
  "SAureus": {
   "ko": "ํ™ฉ์ƒ‰ํฌ๋„์ƒ๊ตฌ๊ท  โ€” ํ‘œ์ค€๊ท ์ฃผ ์ „์„ธํฌ ํŒ์ •",
   "en": "S. aureus (reference strains) โ€” whole-cell readout"
  }
 }
}