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98be852 153a479 9995f5e cfca820 98be852 4a8b66b | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 | {
"note": "๋ถ๋ฌธ ์ด๋ฆ๋ง์ผ๋ก๋ ๋ฌด์์ ์ฌ๋์ง ์ ์ ์๋ค. ํ์ ๊ธฐํธ๋ ์ด ๋ถ์ผ ์ฌ๋์๊ฒ๋ง ์ฝํ๋ค.",
"boards": {
"hERG": {
"ko": "์ฌ์ฅ๋
์ฑ โ ์นผ๋ฅจ์ฑ๋ ์ฐจ๋จ",
"en": "Cardiotoxicity โ hERG channel block"
},
"Solubility": {
"ko": "์์ฉํด๋ โ ๋ฌผ์ ๋
น๋ ์ ๋",
"en": "Aqueous solubility"
},
"Withdrawal": {
"ko": "์ํ ํ ํด์ถ ํ์ ",
"en": "Post-marketing withdrawal"
},
"Phenotype": {
"ko": "์ธํฌ ํํ ๋ณํ โ ๊ตฌ์กฐ๋ง ๋ณด๊ณ ์์ธก",
"en": "Cell morphology response from structure alone"
},
"CYP3A4": {
"ko": "๋์ฌ ์ ํด โ ์ฝ๋ฌผ ์ํธ์์ฉ ์ต๋ ์์ธ",
"en": "CYP3A4 inhibition โ main cause of drug interaction"
},
"CYP2D6": {
"ko": "๋์ฌ ์ ํด โ ๊ฐ์ธ์ฐจ๊ฐ ํฐ ํจ์",
"en": "CYP2D6 inhibition โ highly polymorphic enzyme"
},
"CYP2C9": {
"ko": "๋์ฌ ์ ํด โ ์ํ๋ฆฐ ๊ณ์ด",
"en": "CYP2C9 inhibition โ warfarin class"
},
"EGFR": {
"ko": "ํ์ ํ์ โ ์ํผ์ฑ์ฅ์ธ์ ์์ฉ์ฒด",
"en": "Lung cancer target โ EGF receptor"
},
"JAK2": {
"ko": "๊ณจ์์ฆ์์งํ ํ์ ",
"en": "Myeloproliferative disease target"
},
"PI3Ka": {
"ko": "์ข
์ ์ ํธ์ ๋ฌ ํ์ ",
"en": "Tumour signalling target"
},
"FLT3": {
"ko": "๊ธ์ฑ๊ณจ์๋ฐฑํ๋ณ ํ์ ",
"en": "Acute myeloid leukaemia target"
},
"VEGFR2": {
"ko": "ํ๊ด์ ์ ํ์ โ ์ข
์ ํ๊ด ์ฐจ๋จ",
"en": "Angiogenesis target"
},
"CDK2": {
"ko": "์ธํฌ์ฃผ๊ธฐ ํ์ ",
"en": "Cell cycle target"
},
"HER2": {
"ko": "์ ๋ฐฉ์ ํ์ ",
"en": "Breast cancer target"
},
"ABL1": {
"ko": "๋ง์ฑ๊ณจ์๋ฐฑํ๋ณ ํ์ ",
"en": "Chronic myeloid leukaemia target"
},
"BRAF": {
"ko": "ํ์์ข
ํ์ ",
"en": "Melanoma target"
},
"KIT": {
"ko": "์์ฅ๊ด๊ธฐ์ง์ข
์ ํ์ ",
"en": "GIST target"
},
"ALK": {
"ko": "ํ์ ์ตํฉ ํ์ ",
"en": "Lung cancer fusion target"
},
"AChE": {
"ko": "์์ธ ํ์ด๋จธ ํ์ โ ์์ธํธ์ฝ๋ฆฐ ๋ถํดํจ์",
"en": "Alzheimer target โ acetylcholinesterase"
},
"MAOB": {
"ko": "ํํจ์จ ํ์ โ ๋ชจ๋
ธ์๋ฏผ ์ฐํํจ์ B",
"en": "Parkinson target โ monoamine oxidase B"
},
"COX2": {
"ko": "์์ผ์งํต ํ์ ",
"en": "Anti-inflammatory target"
},
"LogP": {
"ko": "์น์ ์ฑ โ ๊ธฐ๋ฆ๊ณผ ๋ฌผ ์ฌ์ด ๋ถ๋ฐฐ",
"en": "Lipophilicity โ octanol/water partition"
},
"Caco2": {
"ko": "์ฅ ํก์ โ ์ธํฌ์ธต ํฌ๊ณผ ์๋",
"en": "Intestinal absorption โ monolayer permeability"
},
"PPB": {
"ko": "ํ์ฅ๋จ๋ฐฑ๊ฒฐํฉ โ ์ ๋ฆฌ ์ฝ๋ฌผ ๋น์จ์ ์ ํ๋ค",
"en": "Plasma protein binding โ sets the free fraction"
},
"Vdss": {
"ko": "๋ถํฌ์ฉ์ โ ์กฐ์ง์ผ๋ก ์ผ๋ง๋ ํผ์ง๋",
"en": "Volume of distribution โ tissue partitioning"
},
"HalfLife": {
"ko": "๋ฐ๊ฐ๊ธฐ โ ๋ชธ์ ์ผ๋ง๋ ๋จธ๋ฌด๋",
"en": "Half-life โ how long it stays in the body"
},
"D2": {
"ko": "์กฐํ๋ณยทํํจ์จ ํ์ โ ๋ํ๋ฏผ D2",
"en": "Schizophrenia and Parkinson target โ dopamine D2"
},
"MuOpioid": {
"ko": "์งํต ํ์ โ ๋ฎค ์คํผ์ค์ด๋ ์์ฉ์ฒด",
"en": "Analgesia target โ mu opioid receptor"
},
"KappaOpioid": {
"ko": "๋น์ค๋
์ฑ ์งํต ํ๋ณด โ ์นดํ ์คํผ์ค์ด๋",
"en": "Non-addictive analgesia โ kappa opioid receptor"
},
"A2A": {
"ko": "ํํจ์จยท๋ฉด์ญํญ์ ํ์ โ ์๋ฐ๋
ธ์ A2A",
"en": "Parkinson and immuno-oncology target โ adenosine A2A"
},
"HT2A": {
"ko": "ํญ์ ์ ๋ณ ํ์ โ ์ธ๋กํ ๋ 5-HT2A",
"en": "Antipsychotic target โ serotonin 5-HT2A"
},
"CB1": {
"ko": "์นธ๋๋น๋
ธ์ด๋ CB1 ์์ฉ์ฒด",
"en": "Cannabinoid CB1 receptor"
},
"Malaria": {
"ko": "๋ง๋ผ๋ฆฌ์ ์์ถฉ ์ฌ๋ฉธ โ ์ ํ๊ตฌ๋ด ๋จ๊ณ",
"en": "Malaria parasite kill โ blood stage"
},
"LD50": {
"ko": "๊ธ์ฑ๋
์ฑ โ ์น์ฌ๋",
"en": "Acute toxicity โ lethal dose"
},
"Selectivity": {
"ko": "์ฌ์ฅ ์์ ์ญ โ ํ์ ์ธ๊ธฐ์ hERG ์ธ๊ธฐ์ ์ฐจ์ด",
"en": "Cardiac safety margin โ target potency minus hERG"
},
"BACE1": {
"ko": "์์ธ ํ์ด๋จธ ํ์ โ ์๋ฐ๋ก์ด๋ ์์ฑ ํจ์",
"en": "Alzheimer target โ amyloid-producing protease"
},
"BRD4": {
"ko": "์ํผ์ ๋คํฑ ํ์ โ ์ ์ ์ ์ฝ๊ธฐ ์ฐจ๋จ",
"en": "Epigenetic target โ BET bromodomain"
},
"HDAC1": {
"ko": "์ํผ์ ๋คํฑ ํ์ โ ํ์คํค ํ์์ธํธํ",
"en": "Epigenetic target โ histone deacetylase"
},
"HIVRT": {
"ko": "HIV ์ญ์ ์ฌํจ์ โ ํญ๋ฐ์ด๋ฌ์ค",
"en": "HIV reverse transcriptase โ antiviral"
},
"Nav17": {
"ko": "๋ง์ฑ ํต์ฆ ํ์ โ ๋น๋ง์ฝ์ฑ ์งํต ํ๋ณด",
"en": "Chronic pain target โ non-opioid analgesia"
},
"ERalpha": {
"ko": "์ ๋ฐฉ์ ํ์ โ ์์คํธ๋ก๊ฒ ์์ฉ์ฒด",
"en": "Breast cancer target โ estrogen receptor alpha"
},
"Thrombin": {
"ko": "ํญ์๊ณ ํ์ โ ํ์ ํ์ฑ ํจ์",
"en": "Anticoagulant target โ thrombin"
},
"FactorXa": {
"ko": "ํญ์๊ณ ํ์ โ ์ 10์ธ์ Xa",
"en": "Anticoagulant target โ factor Xa"
},
"AR": {
"ko": "์ ๋ฆฝ์ ์ ํ์ โ ์๋๋ก๊ฒ ์์ฉ์ฒด",
"en": "Prostate cancer target โ androgen receptor"
},
"HIVPR": {
"ko": "HIV ํ๋กํ
์์ โ ํญ๋ฐ์ด๋ฌ์ค",
"en": "HIV protease โ antiviral"
},
"SEpidermidis": {
"ko": "ํํผํฌ๋์๊ตฌ๊ท โ ์ ์ธํฌ ํ์ ",
"en": "S. epidermidis โ whole-cell readout"
},
"MTB": {
"ko": "๊ฒฐํต๊ท โ ํ์ค๊ท ์ฃผ H37Rv ์ ์ธํฌ ํ์ ",
"en": "M. tuberculosis H37Rv โ whole-cell readout"
},
"SAureus": {
"ko": "ํฉ์ํฌ๋์๊ตฌ๊ท โ ํ์ค๊ท ์ฃผ ์ ์ธํฌ ํ์ ",
"en": "S. aureus (reference strains) โ whole-cell readout"
}
}
} |