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| { | |
| "note": "๋ถ๋ฌธ ์ด๋ฆ๋ง์ผ๋ก๋ ๋ฌด์์ ์ฌ๋์ง ์ ์ ์๋ค. ํ์ ๊ธฐํธ๋ ์ด ๋ถ์ผ ์ฌ๋์๊ฒ๋ง ์ฝํ๋ค.", | |
| "boards": { | |
| "hERG": { | |
| "ko": "์ฌ์ฅ๋ ์ฑ โ ์นผ๋ฅจ์ฑ๋ ์ฐจ๋จ", | |
| "en": "Cardiotoxicity โ hERG channel block" | |
| }, | |
| "Solubility": { | |
| "ko": "์์ฉํด๋ โ ๋ฌผ์ ๋ น๋ ์ ๋", | |
| "en": "Aqueous solubility" | |
| }, | |
| "Withdrawal": { | |
| "ko": "์ํ ํ ํด์ถ ํ์ ", | |
| "en": "Post-marketing withdrawal" | |
| }, | |
| "Phenotype": { | |
| "ko": "์ธํฌ ํํ ๋ณํ โ ๊ตฌ์กฐ๋ง ๋ณด๊ณ ์์ธก", | |
| "en": "Cell morphology response from structure alone" | |
| }, | |
| "CYP3A4": { | |
| "ko": "๋์ฌ ์ ํด โ ์ฝ๋ฌผ ์ํธ์์ฉ ์ต๋ ์์ธ", | |
| "en": "CYP3A4 inhibition โ main cause of drug interaction" | |
| }, | |
| "CYP2D6": { | |
| "ko": "๋์ฌ ์ ํด โ ๊ฐ์ธ์ฐจ๊ฐ ํฐ ํจ์", | |
| "en": "CYP2D6 inhibition โ highly polymorphic enzyme" | |
| }, | |
| "CYP2C9": { | |
| "ko": "๋์ฌ ์ ํด โ ์ํ๋ฆฐ ๊ณ์ด", | |
| "en": "CYP2C9 inhibition โ warfarin class" | |
| }, | |
| "EGFR": { | |
| "ko": "ํ์ ํ์ โ ์ํผ์ฑ์ฅ์ธ์ ์์ฉ์ฒด", | |
| "en": "Lung cancer target โ EGF receptor" | |
| }, | |
| "JAK2": { | |
| "ko": "๊ณจ์์ฆ์์งํ ํ์ ", | |
| "en": "Myeloproliferative disease target" | |
| }, | |
| "PI3Ka": { | |
| "ko": "์ข ์ ์ ํธ์ ๋ฌ ํ์ ", | |
| "en": "Tumour signalling target" | |
| }, | |
| "FLT3": { | |
| "ko": "๊ธ์ฑ๊ณจ์๋ฐฑํ๋ณ ํ์ ", | |
| "en": "Acute myeloid leukaemia target" | |
| }, | |
| "VEGFR2": { | |
| "ko": "ํ๊ด์ ์ ํ์ โ ์ข ์ ํ๊ด ์ฐจ๋จ", | |
| "en": "Angiogenesis target" | |
| }, | |
| "CDK2": { | |
| "ko": "์ธํฌ์ฃผ๊ธฐ ํ์ ", | |
| "en": "Cell cycle target" | |
| }, | |
| "HER2": { | |
| "ko": "์ ๋ฐฉ์ ํ์ ", | |
| "en": "Breast cancer target" | |
| }, | |
| "ABL1": { | |
| "ko": "๋ง์ฑ๊ณจ์๋ฐฑํ๋ณ ํ์ ", | |
| "en": "Chronic myeloid leukaemia target" | |
| }, | |
| "BRAF": { | |
| "ko": "ํ์์ข ํ์ ", | |
| "en": "Melanoma target" | |
| }, | |
| "KIT": { | |
| "ko": "์์ฅ๊ด๊ธฐ์ง์ข ์ ํ์ ", | |
| "en": "GIST target" | |
| }, | |
| "ALK": { | |
| "ko": "ํ์ ์ตํฉ ํ์ ", | |
| "en": "Lung cancer fusion target" | |
| }, | |
| "AChE": { | |
| "ko": "์์ธ ํ์ด๋จธ ํ์ โ ์์ธํธ์ฝ๋ฆฐ ๋ถํดํจ์", | |
| "en": "Alzheimer target โ acetylcholinesterase" | |
| }, | |
| "MAOB": { | |
| "ko": "ํํจ์จ ํ์ โ ๋ชจ๋ ธ์๋ฏผ ์ฐํํจ์ B", | |
| "en": "Parkinson target โ monoamine oxidase B" | |
| }, | |
| "COX2": { | |
| "ko": "์์ผ์งํต ํ์ ", | |
| "en": "Anti-inflammatory target" | |
| }, | |
| "LogP": { | |
| "ko": "์น์ ์ฑ โ ๊ธฐ๋ฆ๊ณผ ๋ฌผ ์ฌ์ด ๋ถ๋ฐฐ", | |
| "en": "Lipophilicity โ octanol/water partition" | |
| }, | |
| "Caco2": { | |
| "ko": "์ฅ ํก์ โ ์ธํฌ์ธต ํฌ๊ณผ ์๋", | |
| "en": "Intestinal absorption โ monolayer permeability" | |
| }, | |
| "PPB": { | |
| "ko": "ํ์ฅ๋จ๋ฐฑ๊ฒฐํฉ โ ์ ๋ฆฌ ์ฝ๋ฌผ ๋น์จ์ ์ ํ๋ค", | |
| "en": "Plasma protein binding โ sets the free fraction" | |
| }, | |
| "Vdss": { | |
| "ko": "๋ถํฌ์ฉ์ โ ์กฐ์ง์ผ๋ก ์ผ๋ง๋ ํผ์ง๋", | |
| "en": "Volume of distribution โ tissue partitioning" | |
| }, | |
| "HalfLife": { | |
| "ko": "๋ฐ๊ฐ๊ธฐ โ ๋ชธ์ ์ผ๋ง๋ ๋จธ๋ฌด๋", | |
| "en": "Half-life โ how long it stays in the body" | |
| }, | |
| "D2": { | |
| "ko": "์กฐํ๋ณยทํํจ์จ ํ์ โ ๋ํ๋ฏผ D2", | |
| "en": "Schizophrenia and Parkinson target โ dopamine D2" | |
| }, | |
| "MuOpioid": { | |
| "ko": "์งํต ํ์ โ ๋ฎค ์คํผ์ค์ด๋ ์์ฉ์ฒด", | |
| "en": "Analgesia target โ mu opioid receptor" | |
| }, | |
| "KappaOpioid": { | |
| "ko": "๋น์ค๋ ์ฑ ์งํต ํ๋ณด โ ์นดํ ์คํผ์ค์ด๋", | |
| "en": "Non-addictive analgesia โ kappa opioid receptor" | |
| }, | |
| "A2A": { | |
| "ko": "ํํจ์จยท๋ฉด์ญํญ์ ํ์ โ ์๋ฐ๋ ธ์ A2A", | |
| "en": "Parkinson and immuno-oncology target โ adenosine A2A" | |
| }, | |
| "HT2A": { | |
| "ko": "ํญ์ ์ ๋ณ ํ์ โ ์ธ๋กํ ๋ 5-HT2A", | |
| "en": "Antipsychotic target โ serotonin 5-HT2A" | |
| }, | |
| "CB1": { | |
| "ko": "์นธ๋๋น๋ ธ์ด๋ CB1 ์์ฉ์ฒด", | |
| "en": "Cannabinoid CB1 receptor" | |
| }, | |
| "Malaria": { | |
| "ko": "๋ง๋ผ๋ฆฌ์ ์์ถฉ ์ฌ๋ฉธ โ ์ ํ๊ตฌ๋ด ๋จ๊ณ", | |
| "en": "Malaria parasite kill โ blood stage" | |
| }, | |
| "LD50": { | |
| "ko": "๊ธ์ฑ๋ ์ฑ โ ์น์ฌ๋", | |
| "en": "Acute toxicity โ lethal dose" | |
| }, | |
| "Selectivity": { | |
| "ko": "์ฌ์ฅ ์์ ์ญ โ ํ์ ์ธ๊ธฐ์ hERG ์ธ๊ธฐ์ ์ฐจ์ด", | |
| "en": "Cardiac safety margin โ target potency minus hERG" | |
| }, | |
| "BACE1": { | |
| "ko": "์์ธ ํ์ด๋จธ ํ์ โ ์๋ฐ๋ก์ด๋ ์์ฑ ํจ์", | |
| "en": "Alzheimer target โ amyloid-producing protease" | |
| }, | |
| "BRD4": { | |
| "ko": "์ํผ์ ๋คํฑ ํ์ โ ์ ์ ์ ์ฝ๊ธฐ ์ฐจ๋จ", | |
| "en": "Epigenetic target โ BET bromodomain" | |
| }, | |
| "HDAC1": { | |
| "ko": "์ํผ์ ๋คํฑ ํ์ โ ํ์คํค ํ์์ธํธํ", | |
| "en": "Epigenetic target โ histone deacetylase" | |
| }, | |
| "HIVRT": { | |
| "ko": "HIV ์ญ์ ์ฌํจ์ โ ํญ๋ฐ์ด๋ฌ์ค", | |
| "en": "HIV reverse transcriptase โ antiviral" | |
| }, | |
| "Nav17": { | |
| "ko": "๋ง์ฑ ํต์ฆ ํ์ โ ๋น๋ง์ฝ์ฑ ์งํต ํ๋ณด", | |
| "en": "Chronic pain target โ non-opioid analgesia" | |
| }, | |
| "ERalpha": { | |
| "ko": "์ ๋ฐฉ์ ํ์ โ ์์คํธ๋ก๊ฒ ์์ฉ์ฒด", | |
| "en": "Breast cancer target โ estrogen receptor alpha" | |
| }, | |
| "Thrombin": { | |
| "ko": "ํญ์๊ณ ํ์ โ ํ์ ํ์ฑ ํจ์", | |
| "en": "Anticoagulant target โ thrombin" | |
| }, | |
| "FactorXa": { | |
| "ko": "ํญ์๊ณ ํ์ โ ์ 10์ธ์ Xa", | |
| "en": "Anticoagulant target โ factor Xa" | |
| }, | |
| "AR": { | |
| "ko": "์ ๋ฆฝ์ ์ ํ์ โ ์๋๋ก๊ฒ ์์ฉ์ฒด", | |
| "en": "Prostate cancer target โ androgen receptor" | |
| }, | |
| "HIVPR": { | |
| "ko": "HIV ํ๋กํ ์์ โ ํญ๋ฐ์ด๋ฌ์ค", | |
| "en": "HIV protease โ antiviral" | |
| }, | |
| "SEpidermidis": { | |
| "ko": "ํํผํฌ๋์๊ตฌ๊ท โ ์ ์ธํฌ ํ์ ", | |
| "en": "S. epidermidis โ whole-cell readout" | |
| }, | |
| "MTB": { | |
| "ko": "๊ฒฐํต๊ท โ ํ์ค๊ท ์ฃผ H37Rv ์ ์ธํฌ ํ์ ", | |
| "en": "M. tuberculosis H37Rv โ whole-cell readout" | |
| }, | |
| "SAureus": { | |
| "ko": "ํฉ์ํฌ๋์๊ตฌ๊ท โ ํ์ค๊ท ์ฃผ ์ ์ธํฌ ํ์ ", | |
| "en": "S. aureus (reference strains) โ whole-cell readout" | |
| } | |
| } | |
| } |