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Extracellular plaques containing insoluble conjugates of amyloid beta1-42 cleavage product) are a classical indicator of Alzheimer’s disease.Although Aβ has been shown to dysregulate synaptic proteins triggering degeneration of dendritic spines, the underlying cellular machinery is poorly understood.In this context, ac... | The pathogenesis of Alzheimer's disease (AD) is thought to involve acute neurotoxic effects exerted by oligomeric forms of amyloid-β 1-42 (Aβ).While the cellular machinery involved has been extensively explored, to what degree this important signalling cascade occurs in organised brain tissue has remained unclear.Insid... |
application of Aβ oligomers induced a transient elevation of basal astroglial , on average from 70 to 80 nM to 140–150 nM.These results were qualitatively consistent with our observations using fluorescence intensity measures while ruling out the concomitant effects pertinent to the possible changes in cell volume, foc... | Application of Aβ oligomers in physiological concentrations have been shown to transiently elevate internal Ca2+ in cultured astroglia.This elevation did not spread to neighbouring cells and appeared comparable in amplitude with commonly documented spontaneous [Ca2+] rises in astroglia.Principal nerve cells (pyramidal ... |
Primitive hematopoiesis is the first wave of emerging hematopoietic cells during embryonic development and generates predominantly primitive erythroid cells, macrophages and megakaryocytes within the blood islands in the yolk sac.Hematopoietic cells, including definitive hematopoietic stem cells, with multi-lineage pot... | Here, we unravel the function of key transcriptional regulators SCL, LMO2, GATA2, and ETV2 (SLGE) on early hemato-endothelial specification and establish a fully inducible and stepwise hemato-endothelial forward programming system based on SLGE-regulated overexpression.Lange, Schambach, and colleagues established an in... |
as shown in Figure 1A. Expression of TFs was driven and regulated by a tet-inducible promoter and bicistronic expression was achieved using self-cleaving 2A-peptides.To enable positive selection of transduced cells, P2A-puromycin or P2A-zeocin selection marker cassettes were inserted in frame, downstream of the M2 tran... | Induced pluripotent stem cells (iPSCs) offer a promising platform to model early embryonic developmental processes, to create disease models that can be evaluated by drug screens as well as proof-of-concept experiments for regenerative medicine.However, generation of iPSC-derived hemato-endothelial and hematopoietic pr... |
Reproducible and repeatable quantification of right heart function is vital for monitoring patients, yet volume-based measurements are time-consuming, difficult and require meticulous care even in the era of semi-automated boundary detection .Although there is extensive evidence that left ventricular and right ventricu... | Background Reproducible and repeatable assessment of right heart function is vital for monitoring congenital and acquired heart disease.There is increasing evidence for the additional value of myocardial deformation (strain and strain rate) in determining prognosis.This study aims to determine the reproducibility of de... |
relationships between strain or strain rates and increasing age on linear regression analysis.However, with inclusion of the septum, increasing age was associated with a linear decrease in early diastolic strain rate and an increase in late diastolic strain rate .Considering the absence of a consistent impact of age an... | Results RV longitudinal strain (Ell) was − 21.9 ± 3.24% (FW + S Ell) and − 24.2 ± 3.59% (FW-Ell).Early diastolic strain rate (E′) was 1.04 ± 0.26 s− 1 (FW + S) and 1.04 ± 0.33 s− 1 (FW).Late diastolic strain rate (A′) was 0.94 ± 0.33 s− 1 (FW + S) and 1.08 ± 0.33 s− 1 (FW).RA peak strain was − 21.1 ± 3.76%.The intra- a... |
Management of infected chronic wounds has become a major concern for public health and medical practices worldwide, due to increasing prevalence of chronic wounds, escalating antimicrobial resistance and lack of viable methods for delivery of antimicrobials .Chronic wounds include diabetic foot ulcers, venous ulcers an... | Chronic wound infections have become a challenging problem due to escalating antibiotic resistance and lack of viable delivery approaches.Carvacrol (CAR) has been reported to be effective against multidrug resistant pathogens.These NPs were further incorporated into dissolving microneedles (MNs) to facilitate painless ... |
the figure, in case of both CAR-MNs and CAR-PCL NPs-MNs, approximately 90% of the total applied CAR was successfully delivered.Considering the total amount of CAR delivered through MN arrays, a significant percentage of CAR was found in the skin layers for CAR-PCL NPs-MNs even after 24 hours of application, in contrast... | In this study, CAR was formulated into a site-specific nanoparticle (NP) delivery system using poly(caprolactone) (PCL) to achieve a sustained antimicrobial effect at infection sites.Hence, these findings have proven the concept that loading of CAR into this advanced MNs platform can lead to sustained antimicrobial eff... |
change of the oxygen-to-metal ratio can have considerable consequences on the liquefaction temperatures in typical mixed uranium-zirconium oxides that are produced in a NPP core meltdown accident.The application of a quasi-containerless laser heating method together with an improved material preparation via a sol-gel m... | Solid/liquid equilibria in the system UO2–ZrO2 are revisited in this work by laser heating coupled with fast optical thermometry.Phase transition points newly measured under inert gas are in fair agreement with the early measurements performed by Wisnyi et al., in 1957, the only study available in the literature on the... |
generally: how giving up smoking was a threat to male sociality; how struggling to quit was unmanly; and how cessation was a low priority for women invested in an identity of care.New norms relating to e-cigarette use evolved in the context of local meanings of smoking cessation; the success of the e-cigarette in addre... | Research into e-cigarette use has largely focused on their health effects and efficacy for smoking cessation, with little attention given to their potential effect on health inequalities.Drawing on three years of ethnographic research between 2012 and 2015, I investigate the emerging e-cigarette practices of adult smok... |
Vertebrate stereopsis computes something closely related to the cross-correlation between the luminance images captured by left and right eyes .The key insights into vertebrate stereopsis were provided by complex stimuli consisting of random-dot patterns, which can be made correlated, anti-correlated, or uncorrelated a... | Here, we show that mantis stereopsis uses a fundamentally different computational algorithm from vertebrate stereopsis—rather than comparing luminance in the two eyes’ images directly, mantis stereopsis looks for regions of the images where luminance is changing.Strikingly, these insects outperform human observers at j... |
is required at all with another stimulus.In this stimulus, black dots became white and vice versa when the target region passed over them, reverting to their original luminance when it moved away.Thus, in this condition, no dots moved, and the crossed or uncrossed disparities were only conveyed by the position of the l... | Stereopsis is the ability to estimate distance based on the different views seen in the two eyes [1–5].It is an important model perceptual system in neuroscience and a major area of machine vision.Stereopsis has also evolved in at least one invertebrate, the praying mantis [15–17].Mantis stereopsis is presumed to be si... |
the previous experiment.The correlation conditions consisted of one condition were the dots were correlated between the two eyes and one where they were uncorrelated.The stimuli were otherwise like those described for the mantis experiments.Ten individuals were each tested in five sessions.Each session consisted of thr... | Mammalian, avian, and almost all machine stereo algorithms look for similarities between the luminance-defined images in the two eyes, using a series of computations to produce a map showing how depth varies across the scene [3, 4, 6–14].Thus, while there is no evidence that mantis stereopsis works at all with static i... |
either fishing gears, opportunities and skills, money to buy fish, or social relations to receive gifts, as well as culinary knowledge and culture that supports its preparation and consumption.Meanwhile the experiential mechanism of independence and autonomy requires the skills, gears and opportunity to fish.This study... | Despite extensive recent research elucidating the complex relationship between ecosystem services and human wellbeing, little work has sought to understand how ecosystem services contribute to wellbeing and poverty alleviation.This paper adopts concepts from the “Theory of Human Need” and the “Capability Approach” to b... |
for each address in the periods each cohort member had lived at the specific address.Each home address and each WT were geocoded, and the model takes into consideration, meteorological data for each WT every hour throughout the years 1982–2013.There are today >5200 WTs in Denmark, and since 1980s, they have gradually d... | WTN levels at residential addresses between 1982 and 2013 were estimated using the Nord2000 noise propagation model, as the annual means of Lden, Lday, Levening and Lnight at the most exposed façade.Time-varying Cox proportional hazard regression models were used to examine the association between the 11-, 5- and 1-yea... |
correlated with road traffic noise, which has been associated with the increased risk of AF incidence and is traffic related air pollution causes oxidative stress, which is independently associated with risk of AF.Noise estimates and traffic air pollution were available for every year of follow-up and all other potenti... | Mean (standard deviation) baseline residential noise levels amongst exposed nurses were 26.3 (6.7) dB and slightly higher in those who developed AF (27.3 (7.31) dB), than those who didn't (26.2 (6.6)).Similar effects were observed with day (HR 1.25; 95% CI: 1.01–1.54), and evening (HR 1.25; 95% CI: 1.01–1.54) noise lev... |
WHO conditionally recommends that WT Lden levels should be reduced to below 45 dB, much in line with the limits set by the Danish Environmental Protection Agency; of 44 dB and 42 dB for dwellings in open country.This may imply that our findings were chance and that the noise levels in our study may not have induced int... | Background: The potential health effects related to wind turbine noise (WTN) have received increased focus during the past decades, but evidence is sparse.We examined the association between long-term exposure to wind turbine noise and incidence of atrial fibrillation (AF).Conclusions: We found suggestive evidence of a... |
members and served as their mentors as the new trainees began to conduct the scans themselves.Today, we conduct 10-15% quality assurance on all scans to ensure that the quality remains high.The endeavor, however, is not trivial.In the absence of interventions that get at the very deep seeded reluctance among women to i... | We have been conducting research in malaria treatment and prevention in children and pregnant women in Blantyre, Malawi for over a decade.Here, we review some of the unique challenges that we have faced in leading research studies that with rigor and integrity and maintaining the highest ethical standard.We conclude wi... |
Flow based models such as Real NVP are an extremely powerful approach to density estimation.However, existing flow based models are restricted to transforming continuous densities over a continuous input space into similarly continuous distributions over continuous latent variables.This makes them poorly suited for mod... | Flow based models, but non-invertible, to also learn discrete variables |
led to tetraplegia and short atrophic hands and feet.Loss of the ability to walk occurred 7–21 years after disease onset, and most individuals were wheelchair bound by adolescence.Cognitive impairment was present in seven persons, two of whom were severely demented.Alpha-fetoprotein, albumin, and cholesterol levels wer... | The integration of data from these analyses led to the identification of the same homozygous PNKP (polynucleotide kinase 3′-phosphatase) mutation, c.1123G>T (p.Gly375Trp), in three of the studied families.When analyzing this particular gene in the exome sequencing data from the remaining cohort, we identified homozygou... |
the impacts across all the categories, except for the WF and NLT.This is broadly in proportion to their consumption quantities, which amount to 64% of the total fruits sold in the UK.On the other hand, mangoes, which only account for 1% of the consumption, cause 3% of the GWP and PED and 12% of the WF.This is also the ... | Fruits are indispensable for a balanced and healthy diet.However, their environmental impacts remain largely unknown.Using a life cycle approach, this work estimates for the first time the impacts of fruits consumed in the UK.What makes the UK a particularly interesting case is that only 7% of fruits are produced domes... |
sequence identity with human NLRC4, suggests that NLRC4 exists in an ADP-dependent autoinhibited monomeric conformation, with the C-terminal LRR domain occluding the central NBD.23,NLRC4 activation results in a conformational change that exposes the NBD.24,p.W655C resides in the LRR distal to the currently known mutati... | In vitro inflammasome complex formation was quantified by using flow cytometric analysis of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) specks.ASC contributed to p.W655C NLRC4–mediated cytokine release but not cell death.One key set of residues (p.D1010, p.D1011, p.L1012, and p... |
NLRC4 and provide evidence of pathogenicity for this mutation in both a HEK293T overexpression model and genetically modified THP-1 cell models.The clinical and biochemical evidence of MAS and gastrointestinal symptoms in our patients was similar to the original description of AIFEC.6,10,Clinical symptoms and resistanc... | Objective: Here we investigate the mechanism by which a novel mutation in the leucine-rich repeat (LRR) domain of NLRC4 (c.G1965C, p.W655C) contributes to autoinflammatory disease.Results: The p.W655C NLRC4 mutation caused increased ASC speck formation, caspase-1–dependent cell death, and IL-1β/IL-18 production.Mutatio... |
alloys should be avoided as much as possible, and AM technology should preferably be developed to be able to print using lower-impact materials like low-alloy steel.Several characteristics of AM with consequences in the production and use-phase of products have been analysed in this paper, but one aspect that was large... | Potential benefits from implementing the technology include reduced product weight, transportation and material losses, as well as improved functionality and possibility for printing of spare parts.Possible drawbacks are increased energy use in production and the slow printing process.Conventional manufacturing is comp... |
between noise exposure and behavioral thresholds.The interpretation is complicated if different listeners have different degrees of susceptibility to suffering physiological damage from acoustic trauma.It may also be the case that an acoustic event is more damaging depending on when in the lifetime it occurs.It is curr... | An estimate of lifetime noise exposure was used as the primary predictor of performance on a range of behavioral tasks: frequency and intensity difference limens, amplitude modulation detection, interaural phase discrimination, the digit triplet speech test, the co-ordinate response speech measure, an auditory localiza... |
The Energy Strategy and Energy Union call for secure, competitive, and sustainable energy in the European Union and set ambitious goals for the deployment of renewables.By 2030, for example, the EU should rely on renewable sources for 32% of its energy mix .Achieving this target will require all Member States to embrac... | This trend reflects their divergent national energy security interests and leads to different energy (foreign) policy strategies within the Energy Union context.This policy perspective highlights how a multi-speed energy transition among EU Member States affects European energy relations and energy security and explore... |
onstream.And, when renewable resources are abundant, the gas plants—which are more expensive—could be switched off.A third scenario would envision a Europe in which, after initial divergence, the two sides move towards each other in terms of their energy security strategies and desire for network interconnectedness.The... | The transition towards renewable energy is progressing at different speeds among EU member states.Finally, we suggest incorporating an industrial component next to the internal market and common external voice dimensions of the Energy Union, in the form of a package deal, so that the EC might overcome political tension... |
was also strong internal reliability, with a Cronbach's alpha score of 0.83.The other instruments were also found to be valid and reliable, with the details reported elsewhere .Lifetime exposure to violent and traumatic events was measured using an adapted version of the Harvard Trauma Questionnaire .Items from the HTQ... | Background: There are substantial risk factors for somatic distress (SD) among civilian populations affected by armed conflict in low and middle income countries.Our aim was to examine patterns of SD among conflict-affected persons in the Republic of Georgia, which has over 200,000 internally displaced persons (IDPs) f... |
Somatic mutations are non-inherited alterations in DNA that occur in a progenitor cell and become transmitted to its descendant population.They arise at a low frequency by chance, typically during DNA replication, and can be caused by environmental factors such as chemicals or ionizing radiation.Virtually all cancer ce... | Somatic mutations have a central role in cancer but their role in other diseases such as autoimmune disorders is poorly understood.Earlier work has provided indirect evidence of rare somatic mutations in autoreactive T-lymphocytes in multiple sclerosis (MS) patients but such mutations have not been identified thus far.... |
in other cell populations of the same patient.We were able to produce a list of 154 putative somatic mutations for further validation using another sequencing method.We used high-depth next generation sequencing to screen the DNAs for somatic mutations.The sequencing covered all exons of a panel of 986 immune-related g... | We found non-synonymous somatic mutations in 12 (60%) patients (10 MS, 1 myasthenia gravis, 1 narcolepsy).There were 27 mutations, all different and mostly novel (67%).They were discovered at subpopulation-wise allelic fractions of 0.2%–4.6% (median 0.95%).Multiple mutations were found in 8 patients.In follow-up after ... |
is a viable way to discover somatic mutations from non-cancer patients' blood samples, even when the mutant clones are small.Importantly, the results define an interesting hitherto unknown research target for future studies.The major limitation of our study is that at this stage we cannot make any conclusions on the pa... | These results unravel a novel class of persistent somatic mutations, many of which were in genes that may play a role in autoimmunity (ATM, BTK, CD46, CD180, CLIP2, HMMR, IKFZF3, ITGB3, KIR3DL2, MAPK10, CD56/NCAM1, RBM6, RORA, RPA1 and STAT3).Whether some of this class of mutations plays a role in disease is currently ... |
out using the KAPA HiFi polymerase.A second round of PCR utilizing the overhang sequences was then performed to incorporate full Illumina sequencing adapters using primers from the Nextera XT Index Kit.The amplicons were purified after both PCR steps using Agencourt AMPure XP beads.The resulting library was sequenced u... | Somatic mutations were called by comparing the sequence data of each cell subpopulation to other subpopulations of the same patient and validated by amplicon sequencing.The mutations were enriched in CD8 + cells (85% of mutations). |
accuracy exhibited by the new model.Thus, the new model is a better model for predicting liquid loading in deviated gas wells.As the gas-liquid ratio increases with increase in gas production rate, the risk of liquid reduces thus affecting the hole/tube diameter.The tube diameter significantly affects the gas mass flow... | Liquid loading causes undesirable occurrences such as premature death of wells, as well as significant reduction in production.However, most available models consider vertical wells and only a few focus on deviated gas wells.In order to reduce the impact of liquid loading on gas production, gas well load-up should be d... |
and GS are dominant contributors and the remaining two parameters have negligible influence.For the first vertical natural frequency, the parameter GS exhibits the most significant influence, followed by EY, ET and EL, respectively.The interaction effects among parameters are not significant, as was the case for natura... | The novelty of the study is in determining the effects that the uncertainties have on the global structural scale properties rather than component properties often studied in literature.The results reveal that a coefficient of variation (COV) of 10% for four mechanical parameters can lead to COVs of 3.37%, 2.92% and 3.... |
Alzheimer's disease, a progressive form of dementia that interferes with memory, thinking, and behavior, is one of the main threats to the life quality of the elderly.Cognition decline especially memory loss is the clinical hallmark of AD onset, resulting from an irreversible neurodegenerative progress.For therapy to b... | Apolipoprotein E (APOE) e4 is the major genetic risk factor for late-onset Alzheimer's disease (AD).Capitalizing on the study of a large number of cognitively unimpaired late middle aged and older adults with two, one and no APOE-e4 alleles, the current study aims to characterize the ability of our automated surface-ba... |
hippocampal volume size met the left-less-than-right asymmetry pattern in cognitively unimpaired subjects.Our current findings, supported by some prior work, identified that APOE-e4 carriers of cognitively unimpaired subjects had significant left hippocampal atrophy.Our results supported that APOE-e4 is the major genet... | We examined the APOE-e4 dose effect on cross-sectional hippocampal morphology analysis in a magnetic resonance imaging (MRI) database of 117 cognitively unimpaired subjects aged between 50 and 85 years (mean = 57.4, SD = 6.3), including 36 heterozygotes (e3/e4), 37 homozygotes (e4/e4) and 44 non-carriers (e3/e3).The pr... |
results.The normalization methods denote different preferences from decision-makers, from exploiting only the ordinal character of the data to considering quantitative differences between performances.Furthermore, the aggregation functions represent different levels of compensation between indicators.Finally, the Elect... | Indicator-based approaches are suitable to assess multi-dimensional problems.This study proposes the Electricity Supply Resilience Index (ESRI), which is a measure of a nation's electricity supply resilience.Results show a clear country ranking trend, with robust top- and low-performing countries across all combination... |
make-span, will be increased.If the structure of the system can be characterized as a scale-free or a small-world network, the total system reliability is significantly higher than that for the traditional serial/parallel systems.Our results confirm the results of that scale-free/small-world networks are more reliable ... | One of the most important research fields of network sciences is the robustness of networks.A recently answered important question was the following: Which network topologies are more resistant to random malfunctions and/or direct attacks?Nevertheless, until now, “which system topology can be maintained and how to mana... |
this means the number of events identified as coincidences or plasmid dimers is caused by a significant number of plasmid dimers and not only by coincidences.Taking the values in Table 1 together with the expected coincidence rate gives a ratio of% plasmid dimers.With this analysis, it is possible to determine the conc... | Direct detection of single stained DNA fragments in flow is a very sensitive method for nucleic acid detection which does not need any amplification process.We have developed an instrument for direct counting and sizing of single DNA fragments (single or double stranded DNA) in flow with integrated sample volume measur... |
equipment-related description and reasoning .Hence, the seven-step method is used for ontology modeling in this work.Considering the aforementioned characteristics of the polyethylene process domain knowledge, the seven-step method was adopted to construct an ontology of the domain knowledge.As the ontology library mus... | Next, a prediction method is presented for the molecular weight distribution (MWD) based on a back propagation (BP) neural network model, by analyzing the relationships between the operating conditions and the parameters of the MWD.Based on this network, a differential evolution algorithm is introduced to optimize the ... |
OOKBS autonomously extracts the rules from experiences accumulated by experts, production manual, technical specification, and relevant technical literature in the field of the polyethylene process.It also provides logical reasoning-based rules. According to the operating condition data inputted by a user, the OOKBS ca... | Setting up a knowledge base is a helpful way to optimize the operation of the polyethylene process by improving the performance and the efficiency of reuse of information and knowledge—two critical elements in polyethylene smart manufacturing.First, an ontology of the polyethylene process constructed using the seven-st... |
The plant microbial fuel cell is an emerging technology which generates sustainable electricity from living plants .Rhizodeposits are oxidized by electrochemical active bacteria in the anode of the PMFC producing electrons.These electrons are transported to the cathode via an external circuit where energy is harvested.... | Application of the plant microbial fuel cell (PMFC) in wetlands should be invisible without excavation of the soil.The preferred design is a tubular design with the anode directly between the plant roots and an oxygen reducing biocathode inside the tube.In this research silicone was successfully used as gas diffusion l... |
as a result of a lower oxygen concentration and current density when switching from oxygen to air diffusion.This likely resulted in higher concentrations of sulphide in the cathode.The toxic sulphide may have killed the microorganisms .Also the formation of elemental sulphur on the cathode may substantially decrease th... | Oxygen should be passively supplied to the cathode via a gas diffusion layer.The objective of this research is to start-up an oxygen reducing biocathode in situ in a tubular PMFC applied in a Phragmites australis peat soil and a Spartina anglica salt marsh.PMFCs with a biocathode were successfully started in the peat s... |
publicly available hazard and fate information which can be used for an alternative assessment.The quality of the presented data from industry is variable and the data are subject to changes without prior notice.Endpoint specific conclusions are sometimes based on secondary sources or old study reports with insufficien... | Flame retardants (FRs) are a diverse group of chemicals used as additives in a wide range of products to inhibit, suppress, or delay ignition and to prevent the spread of fire.Halogenated FRs (HFRs) are widely used because of their low impact on other material properties and the low loading levels necessary to meet the... |
1970s but are less sensitive due to changes in the hydroclimate, in atmospheric aerosol content, sulfur dioxide immissions and changes in SSR and DTR.Therefore, we propose omitting the last four decades when developing reconstructions of the local-to-regional hydroclimate variability for this area from tree-ring data.B... | Oak tree-ring series contain detailed information regarding climate variability for centuries to millennia.Such reconstructions are compiled with the use of climate response functions that are typically based on monthly precipitation or temperature data sets.We present an approach using a MATLAB® script and long-term d... |
relevant for the onset of different dynamical regimes of hydrated lysozyme.The values of these temperatures agree with those already found for the same system and described in the introduction, which are 225 K and 320 K. All the described changes and their thermal borders are well described by the intensity of the Amid... | The role the solvent plays in determining the biological activity of proteins is of primary importance.Water is the solvent of life and proteins need at least a water monolayer covering their surface in order to become biologically active.We study how the properties of water and the effect of its coupling with the hydr... |
sedimentary sequences, AS-1 to AS-3, deposited parallel to it.Above AS-u3, the reflections become increasingly tapered, reaching their largest internal angles up to AS-u6, and then change to progressively more horizontal and parallel above AS-u6.Subtle low-angle onlaps in the internal geometry of the second order seque... | The seismic sediment record of the Amundsen Sea continental rise provides insight into the sedimentation processes from pre-glacial to glacial times, variations in ocean-bottom circulation, early ice sheet growth, and intensification towards the present icehouse regime.Seismic reflection data acquired during the 2010 R... |
found that only Fus was simultaneously upregulated in both Siha and Hela cells.Therefore, Fus was chosen for next experiments.FUS was initially identified as a fusion protein caused by chromosomal translocations in human myxoid liposarcoma.To prove whether Fus protein was formed by the chromosomal translocations in hum... | Long non-coding RNAs (LncRNAs) have been proved to be closely related to the progression of various cancers, including cervical cancer.In this study, we aim to explore the specific mechanism and biological function of XIST in cervical cancer.At first, the expression levels of XIST were examined in both tissues and cell... |
nm for FDU-12-0, -100, -500, -800 samples respectively.Here, the domain size represents the lower limit for which stirring affects the macroscopic morphology.TEM micrographs were obtained to observe the internal structure and mesophase of all the samples.The images generally reveal large domains of well-aligned, ordere... | Ordered mesoporous FDU-12 silica particles with different morphologies were synthesized by varying the stirring rate.The influence of the stirring conditions on the morphology was demonstrated, as the FDU-12 particle morphology changes from a regular, hexagonal platelet to a poorly defined shape when the stirring rate ... |
this hypothesis was not able to be confirmed because adipose tissue analysis was not part of the standardized subchronic 90-day oral toxicity protocol.Finally, changes in liver histology were not related to Xanthigen® as there was no correlation with the doses used and because they were observed more frequently in the ... | Xanthigen® is a nutraceutical combination for weight management capable of increasing energy expenditure via uncoupling protein 1 (UCP-1) in white adipose tissue.It consists of brown seaweed Undaria pinnatifida extract, rich in the carotenoid fucoxanthin (FX) and pomegranate seed oil (PSO), rich in punicic acid.Xanthig... |
the free FVIII light chain as on intact FVIII molecules.Studies also showed that the VIIISelect affinity ligand forms a more stable complex with intact rhFVIII molecules than with free rhFVIII-LC only.As shown during the development time and in the production process validation, rhFVIII-LC originating from the cultivat... | Aims To describe the development, upscaling and process validation for industrial-scale human-cl rhFVIII purification.Methods and results The purification process involves one centrifugation, two filtration, five chromatography columns and two dedicated pathogen clearance steps (solvent/detergent treatment and 20 nm na... |
Being underweight, overweight, or obese during childhood and adolescence is associated with adverse health consequences throughout the life-course.Underweight among children and adolescents is associated with higher risk of infectious diseases, and for girls of childbearing age, is associated with adverse pregnancy out... | Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults.We used a Bayesian hierarchical model to estimate trends from 1975 to 2016 in 200 countries for mean ... |
adulthood, and hence help inform the estimates in both groups.Posterior estimates were made in 1-year age groups for ages 5–19 years and in 5-year age groups for those aged 20 years and older.For presentation, we used the posterior estimates for ages 5–19 years for children and adolescents, and for ages 20 years and ol... | Methods We pooled 2416 population-based studies with measurements of height and weight on 128.9 million participants aged 5 years and older, including 31.5 million aged 5–19 years.Findings Regional change in age-standardised mean BMI in girls from 1975 to 2016 ranged from virtually no change (−0.01 kg/m2 per decade; 95... |
Asian girls and boys had lower mean BMI than their African peers.Polynesians and Micronesians had the highest mean BMI in those aged 5–9 and 10–19 years, with the subsequent spots held by the high-income English-speaking region, regions in Latin America and the Caribbean, and Melanesia.Among these regions, central Lati... | Global age-standardised prevalence of obesity increased from 0.7% (0.4–1.2) in 1975 to 5.6% (4.8–6.5) in 2016 in girls, and from 0.9% (0.5–1.3) in 1975 to 7.8% (6.7–9.1) in 2016 in boys; the prevalence of moderate and severe underweight decreased from 9.2% (6.0–12.9) in 1975 to 8.4% (6.8–10.1) in 2016 in girls and from... |
30·7% among boys in India.Obesity prevalence was between 1% and 2% among girls in Cambodia, Burkina Faso, Vietnam, Ethiopia, India, Madagascar, Republic of the Congo, Japan, Nepal, Niger, and Chad.Obesity prevalence was less than 1% among boys in Uganda, Rwanda, Niger, Burkina Faso, Ethiopia, Guinea, Chad, and Senegal ... | Prevalence of obesity was more than 30% in girls in Nauru, the Cook Islands, and Palau; and boys in the Cook Islands, Nauru, Palau, Niue, and American Samoa in 2016.Prevalence of obesity was about 20% or more in several countries in Polynesia and Micronesia, the Middle East and north Africa, the Caribbean, and the USA.... |
with data on children aged 5–9 years were school-based measurement studies in high-income countries where school enrolment is almost universal.The relative paucity of data on children aged 5–9 years restricted our capacity to compare trends in this age group with those of adolescents, despite some evidence from high-in... | Background Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course.Funding Wellcome Trust, AstraZeneca Young Health Programme. |
estimate, a perfect density estimate will result in a perfect guidance, with a resultant mean error of zero.However, although atmospheric density generally tends to decrease with increasing altitude, this does not necessarily hold true for any two individual points.This implies that the interpolation will generally, bu... | Spacecraft equipped with the capability to vary their ballistic coefficient can use differential drag as the control force to perform propellant-less relative maneuvers.Because atmospheric drag is proportional to atmospheric density, uncertainty in atmospheric density makes the generation and tracking of drag-based gui... |
Pigmented purpuric dermatosis or capillaritis represents a heterogeneous group of dermatoses of uncertain etiology, which are characterized by pigmented red to brown maculae and petechiae, predominantly on the lower extremities.Classically, five clinical variants of PPD have been described: purpura annularis telangiect... | Granulomatous pigmented purpuric dermatosis clinically manifests as hyperpigmented maculae and petechiae, predominantly on the lower extremities.Histopathologically, it is characterized by a lymphocytic infiltrate in the upper dermis, extravasated erythrocytes, and hemosiderin deposits.There is an infrequent variant ca... |
Traditionally, soft-tissue “balance” during TKA has been determined exclusively by the subjective assessment of each surgeon.However, these imprecise methods contribute to 35% of reasons for revision, based on imbalance-related complications .In light of the anticipated five-fold increase of annual revision procedures ... | Recently, technological advances have made it possible to quantify pounds of pressure across the bearing surface during TKA.This multicenter evaluation, using intraoperative sensors, was performed for two reasons: 1) to define "balance" 2) to determine if patients with balanced knees exhibit improved short-term clinica... |
posterolateral reconstructions, osteotomies, or repair of tibia plateau fractures.For this evaluation, patients were evaluated preoperatively, intraoperatively, at 6 weeks, and at 6 months postoperatively.Two patient-reported outcomes measures were inventoried at each clinical evaluation point, including the American K... | Outcomes scores were compared between "balanced" and "unbalanced" patients.0.001).Out of all confounding variables, balanced joints were the most significant contributing factor to improved postoperative outcomes (P<.0.001).© 2014 The Authors. |
‘We find certain types of remains - pots, implements, ornaments, burial rites and house forms - constantly recurring together.Such a complex of associated traits we shall call a “cultural group” or just a “culture”.We assume that such a complex is the material expression of what today we would call “a people”’.From the... | Here we use archaeological data for this purpose, which brings in a temporal as well as spatial dimension.We analyse two distinct material cultures (pottery and personal ornaments) from Neolithic Europe, in order to: a) determine whether archaeologically defined "cultures" exhibit marked discontinuities in space and ti... |
a positive correlation between time and the dissimilarity of individual sites.Pairwise ΦST and geography, on the other hand, exhibit fairly high levels of correlation, suggesting how, with increasing distance, the proportion of variation among individual sites is increasingly occurring between, rather than within, cult... | Our results support the existence of a robust population structure comparable to previous studies on human culture, and show how the two material cultures exhibit profound differences in their spatial and temporal structuring, signalling different evolutionary trajectories. |
for 18–21 h and immersed into 30% sucrose solution till tissue sunk.Free-floating staining was followed.The tissue was placed on cryomold overlayed with optimal cutting temperature compound.Once frozen, it was properly oriented and sections were cut at 15–30 μm using cryostat.Cut sections were transferred to antifreeze... | Intravenous injection is a standard procedure for delivering human stem cells and therapeutic agents.However, intravenous injections in neonates are difficult.This protocol describes a reliable and reproducible method for injecting cells into the facial vein of P3/P4 (3 or 4 days post-birth) SCID neonates to study thei... |
small number of false positives and 8 in) relative to false negatives and 22 in) demonstrate the high ratio of specificity to sensitivity for this method.We note that some parts of the HDX folding core, for example, residues 86–90, are poorly predicted by all of the methods.This region corresponds to a flexible, surfac... | Determining the folding core of a protein yields information about its folding process and dynamics.The experimental procedures for identifying the amino acids that make up the folding core include hydrogen-deuterium exchange and Φ-value analysis and can be expensive and time consuming.Because of this, there is a desir... |
a range of host-derived metabolites while proliferating inside the host.Aminosugar metabolism, for instance, has recently been found to be essential for successful host colonisation .A key challenge for the rice blast fungus is the ability to colonise and invade plant tissue.Appressorium-mediated invasion of the initia... | Rice blast disease is a major constraint on worldwide rice production and understanding the biology of plant infection is a priority for development of new disease control strategies.Recent advances in live cell imaging, coupled with tractability of both host and pathogen to molecular genetics and genomics, has made th... |
of minority charge carriers.However, due to the fact that peak of power conversion efficiency in the case of white light phosphor-based LED is narrower than for AM 1.5G, the hypothetical power conversion efficiency at such lighting is strongly determined by energy band gap of semiconductor.Table 2 presents maxima of po... | On the basis of the detailed balance principle, curves of efficiency limit of single-junction photovoltaic cells at warm and cool white light phosphor-based LED bulbs with luminous efficacy exceeding 100 lm/W have been simulated.The effect of energy band gap and illuminance on the efficiencies at warm and cool light is... |
A global obesity pandemic, resulting at least in part from altered dietary practices and a decline in physical activity, continues to emerge.Whilst developmental programming and genetic predisposition influence the propensity for obesity , a diet high in calories is a major determinant.Obesity is an established risk fa... | Background Protein kinase G (PKG) Iα is the end-effector kinase that mediates nitric oxide (NO)-dependent and oxidant-dependent vasorelaxation to maintain blood pressure during health.A hallmark of cardiovascular disease is attenuated NO production, which in part is caused by NO Synthase (NOS) uncoupling, which in turn... |
of mice fed a high fat diet .However, the loss of cGMP is not a conclusive evidence of NOS uncoupling, as other mechanisms, such as phosphodiesterase 5 activation or soluble guanylate cyclase inhibition, could also decrease the production cGMP.For example, modulation of the soluble guanylate cyclase redox state can alt... | NOS uncoupling promotes PKG Iα oxidation to the interprotein disulfide state, likely mediated by superoxide-derived hydrogen peroxide, and because the NO-cyclic guanosine monophosphate (cGMP) pathway otherwise negatively regulates oxidation of the kinase to its active disulfide dimeric state.Diet-induced obesity is ass... |
on long-term morphological changes and ecological habitats of marine fish and benthos.It is envisaged that the long-term morphological changes of the Sand Motor are slowed-down by the coarsening of the bed at the exposed coastal sections due to reduced sediment transport of the coarser sand.Initial morphological change... | Bed sediment composition, with a focus on the median grain size D50, was investigated at a large-scale nourishment (The ‘Sand Motor’) at the Dutch coast (∼21.5 million m3 sand).Considerable alongshore heterogeneity of the bed composition (D50) was observed as the Sand Motor evolved over time with (1) coarsening of the ... |
and ultimately allow novel insights into neurobiological mechanisms.The search for mechanistic interpretations of alterations in neuronal dynamics in psychiatric syndromes could also be facilitated by integration of MEG data with advances in computational modeling of whole-brain networks.These computational models have... | The application of neuroimaging to provide mechanistic insights into circuit dysfunctions in major psychiatric conditions and the development of biomarkers are core challenges in current psychiatric research.We propose that recent technological and analytic advances in magnetoencephalography (MEG), a technique that all... |
CO2 permeability, is useful.The most important characteristic of this representation is the upper bound identifying the limiting relationship between gas selectivity and gas permeability, which tend to be inversely related.Since a wide range of polymeric membranes have been proposed to separate CO2 from other gases suc... | In the present work, hybrid block ionomer/ionic liquid (IL) membranes containing up to 40 wt% IL are prepared by incorporating 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]) into a midblock-sulfonated pentablock polymer (Nexar) that behaves as a thermoplastic elastomer.Various analytical techniques, includ... |
Twenty-five percent of patients diagnosed with colorectal cancer present with metastatic disease , with the liver being the predominant site for metastatic spread.Approximately 50% of colorectal cancer patients have liver metastases either at primary diagnosis or following disease recurrence .Surgical resection, where ... | In vitro and pre-clinical studies have suggested that addition of the diet-derived agent curcumin may provide a suitable adjunct to enhance efficacy of chemotherapy in models of colorectal cancer.However, the majority of evidence for this currently derives from established cell lines.Here, we utilised patient-derived c... |
oral curcumin C3-complex daily, 7 days prior to the scheduled chemotherapy.If no curcumin-induced toxicities were observed, daily oral curcumin was continued once chemotherapy commenced.FOLFOX-based chemotherapy consisted of 2-weekly cycles of chemotherapy given to a maximum of 12 cycles or until withdrawal from the tr... | The phase I dose escalation study revealed curcumin to be a safe and tolerable adjunct to FOLFOX chemotherapy in patients with CRLM (n = 12) at doses up to 2 grams daily.Curcumin may provide added benefit in subsets of patients when administered with FOLFOX, and is a well-tolerated chemotherapy adjunct. |
use of models which have greater resemblance to clinical disease , primarily by utilising tissues resected from patients.This allows study of drug action across the heterogenous phenotypic/genotypic cohorts representative of the malignancy under study.CRLM models have thus far rarely been used to study the efficacy of ... | Combination of curcumin with FOLFOX chemotherapy was then assessed clinically in a phase I dose escalation study.Addition of curcumin to oxaliplatin/5-FU enhanced anti-proliferative and pro-apoptotic effects in a proportion of patient-derived explants, whilst reducing expression of stem cell-associated markers ALDH and... |
wounds.Preservatives could enable opened RIG vials to be safely stored at 2–8 °C for up to 28 days increasing vial sharing opportunities, which should be further investigated.Our results showed that mass pre-exposure vaccination for rabies is unlikely to be an efficient use of scarce resources.We assume PEP will always... | To support the SAGE agenda we developed models to compare the relative costs and potential benefits of rabies prevention strategies.Methods: We examined Post-Exposure Prophylaxis (PEP) regimens, protocols for administration of Rabies Immunoglobulin (RIG) and inclusion of rabies Pre-Exposure Prophylaxis (PrEP) within th... |
al. published a similar work demonstrating that disruption of LAPTM4A and TM9SF2 reduced Gb3.The authors demonstrated that loss of LAPTM4A did not change the expression level of endogenous Gb3 synthase.Together with our data that loss of LAPTM4A reduced Gb3 synthase activity in vitro, LAPTM4A may regulate Gb3 synthase ... | To address this knowledge disparity, we focused on biosynthesis of globotriaosylceramide (Gb3), the Shiga toxin (STx) receptor, and performed a genome-wide CRISPR/CAS9 knockout screen in HeLa cells using STx1-mediated cytotoxicity.We identified various genes including sphingolipid-related genes and membrane-trafficking... |
could furnish us with a better understanding of the different ways in which a teacher's multilingual identity can be formed, with implications for teacher development programs and teacher motivation.What is also needed is a deeper exploration of teacher beliefs and a more comprehensive engagement with NNSTs, both in Eu... | With many countries now implementing multilingual educational initiatives in schools, there is a need to reconfigure training programs and encourage teachers to develop a multilingual identity so that they can better promote multilingualism among their students.At present, monolingual ideologies dominate the language e... |
entire country.Deciding when and where to deploy intervention resources raises complex strategic and ethical questions.I have described only two simple scenarios.In Rwanda, it has been convincingly argued that relatively few additional lives could have been saved through external intervention because the true nature an... | Can we predict when and where violence will likely break out within cases of genocide?I present a theoretical model to help identify areas susceptible and resistant to violence during genocide.The model conceptualizes violence onset as a function of elite competition for control of the state from above and the ethnic s... |
acute treatment with cocoa flavanols improved micro- and macro-vascular responses to nutrition.We hypothesized therefore that in older adults, dietary cocoa supplementation would exert beneficial effects related to muscle angiogenesis-related pathways.We did not assess whether 7-day cocoa supplementation caused an incr... | We assessed changes in gene expression of these pathways in muscle from two nutritional intervention studies in older healthy volunteers: (i) 6-weeks daily fish oil supplementation in older females (3.4 g/d; age: 64.4 ± 0.8 y, BMI: 26.2 ± 0.7 kg/m 2 ), and (ii) 7-day daily cocoa flavanol supplementation in older males ... |
We introduce the masked translation model which combines encoding and decoding of sequences within the same model component.The MTM is based on the idea of masked language modeling and supports both autoregressive and non-autoregressive decoding strategies by simply changing the order of masking.In experiments on the W... | We use a transformer encoder to do translation by training it in the style of a masked translation model. |
the transcription profile of L. infantum kinases in promastigotes.We searched for RNA-seq evidence of the species transcriptome in TriTrypDB .A histogram plot was constructed using the percentile of expression of each kinome protein in Leishmania promastigotes.There are 33 highly expressed kinases in L. infantum which ... | A refined bioinformatics pipeline was applied in order to define and compare the kinomes of L. infantum and L. braziliensis, species that cause cutaneous and visceral manifestations of leishmaniasis in the Americas, the latter being potentially fatal if untreated.Respectively, 224 and 221 PKs were identified in L. infa... |
.The cyclin-dependent kinases 2 – CRK1 and CRK3 were experimentally validated in L. mexicana as essential proteins with fundamental roles during cell cycle progression .Also, many inhibitor-driven studies have been carried in order to reach CRK3 inhibition, but few displayed in vitro activity .Recombinant GSK3 was expr... | Therefore, there is an urgent need to identify new targets for the development of new antileishmanial drugs.Protein kinases (PKs), which play an essential role in many biological processes, have become potential drug targets for many parasitic diseases.Furthermore, revealing the kinomes for both Leishmania species allo... |
compared to new investment requirements in alternative technologies on a greenfield.Thus, the design of financial instruments could be given a much more prominent role for incentivizing such fundamental structural transformation.Additionally, given the extraordinary long lifetime of blast furnaces, future investigation... | Climate change is one of the most serious threats to the human habitat.The required structural change to limit anthropogenic forcing is expected to fundamentally change daily social and economic life.The production of iron and steel is a special case of economic activities since it is not only associated with combustio... |
educators need to relate research with teaching in a student-focused way, such as involving students in research.Sufficient support from the university to give individual teachers more control over their own teaching and research would be important.Teacher educators then could decide in which specific ways to link thei... | This study explores teacher educators’ perceptions of their approaches to teaching and the closeness of their research and teaching.A total of 115 participants completed a questionnaire.The results showed that these teacher educators perceived information transmission as an element of the student-focused approach to te... |
transferred to a 96-well plate.Hourly OD600 measurements were performed at 30°C for 15 h by using a Tecan Spark® microplate reader.10-20 μg of genomic DNA were treated either with 0.3 M KOH or 0.3 M KCl in a final volume of 40 μl at 55°C for 2 h in the dark.6x alkaline loading buffer was added to KOH treated samples, w... | RNA-DNA hybrids are tightly regulated to ensure genome integrity.Loss of RNase H2 function is implicated in human diseases of the nervous system and cancer.To better understand RNA-DNA hybrid dynamics, we focused on elucidating the regulation of the RNase H enzymes themselves.Using yeast as a model system, we demonstra... |
Sequence analysis identifies DF07 as a novel strain of Stenotrophomonas maltophilia, a member of the Xanthomonadaceae family from the Gammaprotebacteria class.This Gram-negative bacterium is ubiquitously distributed throughout both soil and aquatic environments.S. maltophilia is known to be an opportunistic human patho... | Stenotrophomonas maltophilia DF07 is a gram negative bacterium isolated from polluted San Jacinto River sediment near Moncrief Park in Channelview, Texas.The genome of strain DF07 (chromosome and plasmid) was compiled at the scaffold level and can be accessed through the National Center for Biotechnology Information da... |
would make workers both more inclined and more empowered to negotiate reduced working hours.The purpose of this article has been to highlight three interconnected blindspots in ecological economics: the threat of intensified rent-seeking in a resource-constrained future, the roles that rent-seeking and concentrated ren... | Ecological economists aim to transform our economic institutions so that society can flourish within planetary boundaries.The central message of this article is that private rent extraction forms a key barrier to the realisation of that goal.I define rent as an economic reward which is sustained through control of asse... |
agencies and international organizations has helped build capacity and promote stakeholder involvement in developing countries.Better integration of SEA with adaptation decision making could be valuable because of complementarities in objectives and approaches.The European Commission has suggested using risk based appr... | Climate change adaptation is unavoidable, particularly in developing countries where the adaptation deficit is often larger than in developed countries.Robust Decision Making (RDM) approaches are considered useful for supporting adaptation decision making, yet case study applications in developing countries are rare.Th... |
time in the channel could be increased almost arbitrarily, hence the conclusions of this work are expected mainly to apply.Minimization of the droplet size, i.e. volume for droplet reactions, could be approached by manufacturing a better defined exit hole at the microreactor tip.In spite of the issues mentioned above, ... | A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced.The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainless steel 316L.The functionality of the microreactor was investigated by... |
to maintain soil salinity below a desirable level, or production variability assessments with changing soil salinity levels under different potential management strategies.Both models are useful for scenario analyses on water quality management and environmental conditions such as climate change.Simulated rice yield de... | Development and testing of reliable tools for simulating rice production in salt-affected areas are presented in this paper.New functions were implemented in existing crop models ORYZA v3 and the cropping systems modelling framework APSIM.Field experiments covering two years, two different sites, and three varieties we... |
wildebeest species and population dynamics held on various farms.Therefore, this study should not be considered as research involving human participants.As such, we did not seek ethics approval concerning human participants.Research adheres to the highest of ethical codes of conduct provided by the university.Specifica... | A total of 6929 translocated black and blue wildebeest from 273 private ranches and 3 provincial protected areas protected (PPAs) were documented over 5 years, across 5 South African provinces.Findings indicate (1) 58.45% of sampled private ranches manage for both wildebeest populations, (2) blue wildebeest males are p... |
skewed towards that of male blue wildebeest.We attribute this to the nature of the game translocation industry: owners buy individuals from several ranches with the management goal of outbreeding in order to increase genetic diversity, and game captures are task with capturing a certain number of individuals.This addit... | Due to recent evolutionary divergence, black wildebeest (Connochaetes gnou) and blue wildebeest (Connochaetes taurinus) can mate and produce fertile offspring when sympatric.We caution against risks posed by the game industry upon the PPA's ability to function as nature conservation units and act as stocking sources an... |
to wildebeest translocations suggest that its role as a management practice is likely to persist long term in its current form, and that wildebeest populations are likely to continue to be impacted by it.This is concerning in light of our evidence warning against deleterious conservation implications which include hybr... | We analyzed dispersal patterns and wildlife ranching economics to identify conservation implications and to infer if translocations are likely to persist in their current form.Unwanted conservation implications concern ecological integrity, genetic swamping, and regulatory efficiency.This is indicative of its likelihoo... |
the main reaction products.Tetrasodium etidronate was heated 5 h at 350 °C in muffle furnace.After the reaction was completed and cooled to room temperature, the residue was dissolved in a minimal amount of water at 20 °C, and insoluble materials were filtered off.The filtrate was diluted twofold with water and a CO2 f... | Inorganic pyrophosphate (PPi) mimetics designed on a basis of methylenediphosphonic acid backbone are promising inhibitors of two key HIV replication enzymes, IN [1] and RT [2].Herein, we present chemical synthesis of eleven methylenebisphosphonates (BPs) with their NMR and HRMS analysis synthesized via five different ... |
addition, the SOSA molecules had a plasticizing effect on the EC.As a result, the gel made from the combination of these two gelation strategies showed improved functional properties compared to gels made with either pure system.Edible oil EC gels tend to be shear-sensitive, due to irreversible destruction of the polym... | Background Edible oleogels, oils structured by non-triglyceride networks, can be used for the delivery of lipid-soluble molecules due to their composition, functional properties, and structure.Different oleogelators exist, including small molecules that crystallize to form colloidal or fibrillar networks and hydrophobi... |
to utilise the recirculation pipe as a supply pipe in heating seasons since it is not in operation.Such use of the recirculation pipe has not been considered, as the capacity demand for space heating is much lower compared to domestic hot water preparation, especially in the future case.Thus, a capacity deficit in the ... | Hence, current district heating technology should be enhanced to increase system performance in new heat distribution areas.This paper aims to outline a proposal for technical improvements required to achieve lower annual average return temperatures in new residential buildings to improve viability in future market con... |
on P4 as well as general beach face deflation of 0.5–1 m. Time-lapse images every 30 min allowed better understanding of the influence of nearshore morphology and topographic changes alongshore.Examination of the time lapse camera images located at the northern part of the site, supported the infilling of the intertida... | In fact, around 6000 m3 of net erosion occurred along the 420 m stretch of coastline with maximum differences in beach topographic changes of 0.8 m. The majority of the sediment redistribution occurred within the intertidal and lower beach zone with some limited dune trimming in the southern section (10% of the total e... |
likely to be influential.Understanding the drivers of coastal erosional response requires adequate topographic and hydrodynamic data measurements before and soon after storms.Most storm impact studies, however, are only able to access much longer and coarser datasets ranging from a single survey 3–4 months up to 12 mon... | Low frequency, high magnitude storm events can dramatically alter coastlines, helping to relocate large volumes of sediments and changing the configuration of landforms.This brings added potential risk to coastal environments and infrastructure in northwest Europe and therefore understanding how these high-energy storm... |
scanned at high magnification, and all observed cells scored for X/Y status.Counting was continued until at least 400 cells had been counted for each slide stained, or until all cells on the slide had been counted if fewer than 400 were present in any given fraction.The data were modeled using a beta regression using a... | Mouse sex chromosome evolution has been shaped by widespread gene amplification, due to genomic conflict over offspring sex ratio.show that male mice with a partial Y chromosome deletion show impaired morphology and motility of Y- versus X-bearing sperm, revealing the physiological basis of the sex ratio drive underpin... |
the simulator to restrain the AP motion, they were separated by 47 mm and therefore also applied restraint to the TR motion.High tension springs were tested with a 2.5 mm and 0 mm gap.Both high and low tension springs with a 2.5 mm gap were used to investigate the effect of spring tension.Differences in the results bet... | Abnormal mechanics and wear of TKRs can lead to implant loosening and early failure.Polyethylene inserts of varying design and conformity have been introduced in the past decade to improve stability and patient's confidence in the replaced knee, particularly in cases where soft tissue support around the knee is sub opt... |
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