text stringlengths 330 20.7k | summary stringlengths 3 5.31k |
|---|---|
kinetics of the HDDR reaction and would therefore require further work in order to establish the precise processing conditions and hence commercial viability of this process.Further studies at 880 °C have shown that increasing the disproportionation pressure to 2000 mbar for composition 1 reduced the remanence to 0.72 ... | It has been shown that by increasing the processing temperature, an increase in the equilibrium pressure for disproportionation and in the overall reaction time was observed.The magnetic properties of the lower Dy content magnet were affected significantly by the change in processing temperature with a peak in properti... |
Nature produces unfortunate but informative experiments in the form of brain diseases or injuries whose consequences can yield unique insights on the roles of different brain regions in various aspects of cognition.This article concerns conceptual knowledge or semantic memory, and the ‘natural experiment’ under conside... | Semantic dementia (SD) is a condition in which atrophy to the anterior temporal lobes (ATL) produces a selective deterioration of conceptual knowledge.As this atrophy is always bilateral but usually asymmetrical, differences in performance of the two SD subgroups—with left > right (L > R) versus right > left (R > L) at... |
the posterior occipito-temporal networks in the right hemisphere are at least somewhat specialised for faces and perhaps other visual objects, the right ATL will receive stronger input than the left for this type of stimulus in the healthy brain.Ikeda, Patterson, Graham, Lambon Ralph, and Hodges proposed this idea to e... | We explored this issue using large scale case-series methodology, with a pool of 216 observations of neuropsychological data from 72 patients with SD.Importantly, the size of our sample allowed us to demonstrate considerable individual variation within each of the L > R and R > L subgroups, with consequent overlap betw... |
> R patients.The picture naming task, consisting of either the 48- or 64- item version of the Cambridge Semantic Battery, as described in Woollams et al., involved a series of single pictures presented on individual sheets of paper for a naming response."Patients' responses were scored as correct if they produced eithe... | Anomia was significantly more severe in the L > R subgroup, even when cases from the two subgroups were matched on severity of comprehension deficits.For subgroups matched on the degree of anomia, we show that asymmetry of atrophy also affected both the nature of the naming errors produced, and the degree of a semantic... |
a disadvantage for living things is that, at least at the ‘basic’ level of categorisation, there is a higher degree of visual similarity between living things than artefacts.As a consequence, in an impaired system, it is more likely that one living thing will be confused with another than is the case for manmade artefa... | A comparison across tasks varying in their loading on verbal and visual processing revealed a greater deficit in object naming for L > R cases and in a picture-based semantic association test for R > L cases; this held true whether severity across subgroups was controlled using pairwise matching or statistically via pr... |
itself, we return to the question of why this difference is observed.As already indicated in the Introduction, we are using the short-hand description of ATL Representations versus ATL Connections to characterise the why-question.So the question becomes: does this difference arise because the central semantic represent... | Our results paint a clear picture of how asymmetry of atrophy affects cognitive performance in SD, and we discuss the results in terms of two mechanisms that could contribute to these differences: variation in the information involved in semantic representations in the left and right ATL, and preferential connectivity ... |
reported correlation between Hs and K is confirmed and extended by the CAST system.There is a strong, linear trend of Hs and K. With increasing substitution of Tm2O3 for Al2O3, HS increases up to a value of about 11 GPa for CAST16.Oxide glasses with K exceeding 80 GPa have already been reported .Even though processing ... | We report lateral deformation experiments on rare earth substituted glasses from percalcic CaO-Al 2 O 3 -SiO 2 -Tm 2 O 3 .Using instrumented Berkovich indentation with normal loads below 100 mN, the scratch hardness was obtained from the work of lateral deformation per deformed volume in the elastic-plastic regime.The ... |
one of the markers for INH resistance.We also report of a less prevalent inhApro mutation -17G/C which was earlier reported in some Ghanaian isolates , however unlike the earlier report, this study found the affected isolate had no other mutation in all the other targets analysed suggesting that it could be responsible... | Specific drug resistance associated genetic elements of drug resistant strains were analyzed for mutations.We found the Ghana spoligotype to be associated with drug resistance (INH: 22.1%; p = 0.0000, RIF: 6.2%; p = 0.0103, MDR: 4.6%; p = 0.0240) as compared to the Cameroon spoligotype (INH: 6.7%, RIF: 2.4%, MDR: 1.6%)... |
were not present in infancy.Recent theories have suggested that the early stages of sexual maturation may constitute a ‘switch-point’ in the development of attachment strategies, and that adult attachment styles may be more influenced by recent interpersonal experiences than distal, early caregiving experiences.The att... | Background: Attachment theory proposes that humans develop representations of self and other in early childhood which are relatively stable across the life-course, and play a key role in psychological adaptation.However, to date, the psychometric properties of attachment measures in middle childhood and adolescence hav... |
was performed for multiple testing.A larger study of 63 patients with NSCLC who underwent SBRT tested standard metrics and 13 texture features in 18F-FDG PET/CT for disease-specific and overall survival.On multivariate analysis, only dissimilarity, a second-order feature derived from co-occurrence matrices, was associa... | Purpose: Radiomics describes the extraction of multiple, otherwise invisible, features from medical images that, with bioinformatic approaches, can be used to provide additional information that can predict underlying tumor biology and behavior.Methods and Materials: Radiomic signatures can be used alone or with other ... |
Distinct shorelines, located high above present-day lakes and valley floors, were described from the central Scandinavian mountain range already in 1734 CE by Carl von Linné.By the late 19th and early 20th century many more such shorelines had been found all along the mountain range and was interpreted to have been for... | Some early pioneering works have presented similar reconstructions, whereas more recently published reconstructions place the last ice remnants in the high mountains of Sarek.Using high-resolution airborne LiDAR data we have mapped a large number of hitherto undocumented shorelines in some of the main valleys within th... |
these deposits have previously been studied and explained to be the result of several drainages of ice-dammed lakes during the deglaciation.The LiDAR data have now made possible more detailed mapping of features characteristic of large-scale floods in this densely forested area.Using LiDAR data, we have traced large er... | Our results indicate that a larger system of ice-dammed lakes existed in this region than previously thought.The shorelines dip towards the northwest with gradients ranging from 0.5 to 0.4 m/km, from the oldest to the youngest.Further, we have compiled Lateglacial and Holocene shoreline data along the Norwegian coast a... |
a pattern of large ice-dammed lakes in northern Sweden that can only be explained by an eastward retreating ice sheet margin with ice-dammed lakes formed in deglaciated valleys between the water divide and the ice margin.The distribution of the ice-dammed lakes suggest that the ice sheet retreated away from the Sarek a... | We present geomorphological evidence of large, previously undocumented, early Holocene ice-dammed lakes in the Scandinavian Mountains of northwestern Sweden.The lakes extents indicate that the last remnants of the Scandinavian Ice Sheet were located east of the mountain range.The lakes were dammed between the main wate... |
years there are emerging evidence for studies involved human iPSCM in basic science, regenerative medicine, and the pharmaceutical industry.Although much progress has been made in the genetic and electrophysiological characterization of iPSCMs, it is not understood well how metabolic phenotypes are affected in the cour... | These workflows require a fully functional characterization of iPSCMs.Here we report a step by step protocol for iPSCM metabolic characterization.The described assays cover analysis of small metabolites involved in a vital metabolic pathways. |
ally strategies with other parties can seduce a substantial part of the population.However, policy makers should be aware that a significant number of SMEs are already collaborating, and these SMEs might benefit from policy measures without changing their behavior.We further advise policy makers to proceed with care wh... | When engaging in an innovation project, small- and medium-size enterprises (SMEs) can choose to engage in three different strategies: make, buy and ally (MBA).As collaborating firms are seen as more innovative, policy makers actively promote the ally strategy using various measures.However, when SMEs choose to engage i... |
The effects of new treatments in randomized controlled trials are often measured by test instruments that record patient- or clinician-reported “subjective” outcomes.Typically, there are a range of test instruments available to investigators.For example, the efficacy of treatments for depression may be evaluated by the... | Methods This is illustrated in a synthesis of eight placebo-controlled trials of TNF-α inhibitors in ankylosing spondylitis, each reporting treatment effects on between two and five of a total six test instruments.Conclusions The method should be assessed in a wide range of data sets on different clinical conditions, b... |
the number of data points.The fit of each trial seems adequate.The second plots the residuals and allows us to check that none of the outcomes are associated with a systematic error.We explored the effect of raising or lowering the assumed correlations between change scores on different instruments.Making all the corre... | Objectives A new method is presented for both synthesizing treatment effects on multiple outcomes subject to measurement error and estimating coherent mapping coefficients between all outcomes.It is underpinned by a structural equation model that includes measurement error and latent common treatment effect factor.Resu... |
has not been measured in a trial .Mappings based on trial-generated treatment effects have not, it appears, been envisaged so far in the literature.Instead mappings have been estimated from cohort studies, usually from cross-sectional data in which patients with the condition in question are assessed on both the DSM an... | It can be applied to sets of trials reporting different combinations of patient- or clinician-reported outcomes, including both disease-specific measures and generic health-related quality-of-life measures.Treatment effects can be expressed on any of the test instruments that have been used.Combining synthesis and mapp... |
and day 18, but returning to a level which was comparable with baseline at 1.5 years.In humans, memory B cells can persist for the life of the host; however, typically, levels of circulating immunoglobulin decline rapidly following clearance of the antigen .Thus, if the antigen is not reencountered in vivo, immunoglobu... | Background: We have previously demonstrated that polyfunctional Ty21a-responsive CD4+ and CD8+ T cells are generated at the duodenal mucosa 18 days following vaccination with live-attenuated S. Typhi (Ty21a).The longevity of cellular responses has been assessed in peripheral blood, but persistence of duodenal responses... |
The data being shared consists in a comparison of mass spectrum and chromatogram of the free sugars used to quantify the isotopic enrichments between our previous method using low resolution mass spectrometry, and our new method using high-resolution mass spectrometry .Chromatograms showing separation of free sugars ar... | The data presented in this article are related to the research article entitled “13C labeling analysis of sugars by high resolution-mass spectrometry for Metabolic Flux Analysis” (Acket et al., 2017) [1].This article provides data concerning the comparison between the theoretically expected values of free sugars mass i... |
The causes of giftedness in cognitive or physical abilities are complex, involving both genetic and environmental contributions.Humans with exceptional abilities may have innate potential, but skills must be developed over time, and an individual requires a combination of ambition, opportunity and a willingness to work... | From the genetic side, giftedness in cognitive development is the result of contribution of many common genetic variants of small effect size, so called polygenicity (Spain et al., 2016).From the environmental side, educationalists have argued for the importance of the environment for sustaining early potential in chil... |
generalisation performance to novel rhymes = 0.477, p = 0.491, n = 0.002).That is, sustained giftedness could be distinguished from renorming giftedness at the point where the groups were defined, based on performance on the training set, but not generalisation performance.Sustained gifted individuals acquired knowledg... | Such correlational data need to be complemented by mechanistic models showing how gifted development results from the respective genetic and environmental influences.Variability was produced by many small differences in neurocomputational parameters each influenced by multiple artificial genes, instantiating a polygeni... |
genetic reasons.This contrasts with the usual interpretation of the data presented by Feinstein that changes in population rank solely reflect environmental influences.Lastly, there was some indication that early behavioural profiles could predict whether an individual would exhibit a sustained gifted outcome without k... | A neurocomputational model of cognitive development is presented, using artificial neural networks to simulate the development of a population of children.The simulations captured several key empirical phenomena, including the non-linearity of developmental trajectories, asymmetries in the characteristics of the upper ... |
based on reports by Bhagwat et al., Thomas and Puthur, Faisal et al. and Lata et al.In Pinus brutia Ten., higher rates of direct organogenesis were achieved using 4.5 μΜ TDZ.Prolonged culture in TDZ may exert adverse effects on the plants.In vitro root formation was induced from shoot tip cultured in different concentr... | Moringa peregrina is an important indigenous plant found in United Arab Emirates (UAE).It is an endangered species with important nutritive and medicinal properties.Environmental restrictions, urban expansion and unmanaged grazing endanger the plants.In this study, in vitro propagation of M. peregrina was carried out u... |
Glass ionomer cements are a mainstay of modern dentistry.Their uses include temporary and permanent restorations, lining and luting materials, fissure sealants and in atraumatic restorative therapy.Although GICs exhibit fluoride release, and antimicrobial effects of this can be demonstrated in vitro, the data in suppor... | Objective: Glass ionomer cements (GICs) are a versatile material, offering the opportunity for ion exchange with the oral environment.Methods: GICs were supplemented with finely milled particles of chlorhexidine hexametaphosphate (CHX-HMP).Mechanical properties were investigated, and an agar diffusion test was carried ... |
by the interaction between the microbe and the antimicrobial, but also by the ease by which the antimicrobial can diffuse through the agar.CHX, being a comparatively large molecule, diffuses through agar less readily than some antiseptics.The aim of the disc diffusion study was to take the first steps in assessing whet... | The aim of this study was to develop a GIC that delivers a controlled, rechargeable dose of chlorhexidine (CHX) over an extended period without compromising mechanical properties.Compared with related studies of GICs containing CHX-HMP, the fine, dry particles resulted in fewer adverse effects on mechanical properties,... |
min at 5000 × g. Total proteins were subsequently precipitated with cold acetone, incubated at −80 °C for 2 h, centrifuged for 5 min and re-suspended in 100 μL of 100 mmol L−1 sodium phosphate buffer.Total protein concentration was determined following the method described by Bradford .The precipitated proteins were an... | The composition of a culture medium is one of the most important parameters to be analyzed in biotechnological processes with industrial purposes, because around 30-40% of the production costs were estimated to be accounted for the cost of the growth medium [1].Since medium optimization using a one-factor-at-a-time app... |
easily and quickly.So the increase in concentration in such cases will have positive impact on permeate flow rate by increasing inter particle interaction, which reduces quickly and easily clogging of membrane pores.But after some critical concentration the dominating factor on the permeate flow rate quantity will not ... | Wastewater containing heavy metals is serious issue for Environmentalist.High percentages of heavy metal in wastewater effect the surrounding Environment as well as harmful for animal, plant and human health.The wastewater generated from tannery industries having large amount of suspended solid, organic, inorganics and... |
that people with earlier-onset PCA may possess genetic risk factors that predispose them to develop both earlier AD and PCA and may potentially lead to the specific clinico-anatomical phenotype of this group.Unfortunately, ApoE status was not available for the present study.In our study, there was an association betwee... | Age at onset (AAO) has been shown to influence the phenotype of Alzheimer's disease (AD), but how it affects atypical presentations of AD remains unknown.Posterior cortical atrophy (PCA) is the most common form of atypical AD.In this study, we aimed to investigate the effect of AAO on cortical thickness and cognitive f... |
Mesenchymal stem cells are able to modulate immune responses and inflammation.Several studies have shown that MSCs derived from adipose tissue and other MSCs can improve allergic airway inflammation in the allergic rhinitis and asthma.Although the immune suppression mechanism of MSCs in allergic airway diseases is not ... | Although stem cell-derived extracellular vesicles (EVs) have been shown to facilitate regeneration of injured tissue, there is no report that evaluates the immune-modulating effect of stem cell-derived EVs on Th2-mediated inflammation.The EVs were isolated from supernatant of ASCs and the diameters of EVs were measured... |
demonstrated that the majority of the particles were microvesicles, with the majority having a size range of approximately 100–200 nm.Asthma and atopic diseases are known to be induced by environmental allergens and epithelial cells, as the first cell type to encounter allergens, have been shown to initiate tissue infl... | In this study, we evaluated the immunomodulatory effects of adipose stem cells (ASCs)-derived EVs on Th2-mediated inflammation induced by Aspergillus protease antigen in lung epithelial cells.Real time PCR was performed to determine the expression levels of eotaxin, IL-25, TGF-β, and IL-10 mRNAs after EV treatment.To e... |
A cold region is often defined as an area in which the ground temperature during the coldest month of the year is below 0 °C .Cold regions fitting this definition account for over 50% of the global land area.A portion of the pore water in the soil of a cold region is frozen into ice at below-freezing temperatures, and ... | Over 50% of the global land area suffers cyclic freeze-thaw actions, resulting in extensive distribution of frozen soil.To address this lack of knowledge, we conducted large-scale tests on numerous samples (≥50 specimens under each set of conditions) and measured the thermal conductivities of frozen clay from the Qingh... |
intuitively describe the distribution of the thermal conductivities of the frozen clay.When the water content of the clay increases to 14%, an obvious gap appears between the Weibull distribution and measured curve with a maximum difference of 0.143 at-2 °C.At this water content, the other 3 probability distributions r... | Frozen soil contains lenses of ice, and thus, it exhibits temperature-related properties and behaviors.The thermal conductivity of frozen soil is a key property and an essential parameter for performing thermal analyses on frozen soil.However, the thermal conductivity is variable and cannot be determined accurately bas... |
By following the synthetic routes described here below, we successfully synthesized four biotinylated probes of artemisinin that were used as molecular tools for the affinity labeling of Trypanosoma brucei brucei target proteins .We first prepared the photoaffinity-labeling unit 6 according to the method described by H... | In this data article, we described the synthetic routes to four biotinylated probes (.2, 3, 4, and 5) of artemisinin and the associated experimental procedures.We also provided the physical data for the synthesized compounds.These synthesized biotinylated probes of artemisinin are useful molecular tools for the affinit... |
ig greater than 25% with Q-factor of the cantilever resonant spectrum approximately 3% .Bao et al. fabricated cantilever-based sensors for detecting volatile-organic-compounds using resonant frequency techniques in the gas phase with highest Q-factor which is also capable of detecting aniline and acetic-acid solution i... | Cantilever plays a significant role in sensing of gases with miniaturing technology replacing conventional sensors.In this paper, the micro-cantilever array was simulated using COMSOL Multiphysics 4.2 and Ansys environment to analyze the microcantilever array based on resonant frequency mechanism.From the simulation re... |
with dimensions are shown in Fig. 9 and.The micro-cantilever before and after ozonation was analyzed by laser doppler vibrometer to determine the responses such as quality factor along with frequency and deflection.It is evident that high-quality factor is required for stable operation in case of without ozonation and ... | The fabricated cantilever array was tested by Laser Doppler Vibrometer on exposing it to ozone gas to find the resonant frequency of each cantilever in a micro-cantilver array.From the simulation and fabrication results, it was found that these results were well-matched and the design is best suited for sensing the ozo... |
Conversational question answering is a novel QA task that requires the understanding of dialogue context.Different from traditional single-turn machine reading comprehension, CQA is a comprehensive task comprised of passage reading, coreference resolution, and contextual understanding.In this paper, we propose an innov... | A neural method for conversational question answering with attention mechanism and a novel usage of BERT as contextual embedder |
Intermittent administration of teriparatide increases bone mineral density and improves microarchitecture through its anabolic effect on bone .Once-weekly teriparatide injection at a dose of 56.5 μg and daily teriparatide injection at 20 μg are currently available for the treatment of primary osteoporosis with high fra... | Weekly administration of teriparatide has been shown to reduce the risk of vertebral and non-vertebral fractures in patients with osteoporosis at higher fracture risk in Japan.To gain insight into the effect of weekly teriparatide on the hip, hip structural analysis (HSA) based on dual-energy X-ray absorptiometry (DXA)... |
significant decrease compared with baseline in the placebo group, although it showed an increase both at the IT and shaft.The decrease in OD at the NN in the placebo group is not consistent with previous reports that showed a significant age-related increase in OD by HSA .At a region of very thin cortex, such as the up... | However, its efficacy for hip fracture has not been established.The results indicate that overall structural strength in the proximal femur increased compared to placebo, suggesting that once-weekly teriparatide effectively reverses changes in hip geometry and strength with aging. |
Genomic DNA of balanced reciprocal translocation carriers was sequenced in a MinION flow cell with a 48 -h sequencing protocol .In brief, genomic DNA was extracted from peripheral blood using QIAamp DNA Blood Mini kit.The integrity of the DNA was confirmed by gel electrophoresis.One microgram of DNA was used to prepare... | Long-read nanopore sequencing enables direct high-resolution breakpoint mapping on balanced carriers of reciprocal translocation.The mean sequencing depth on the translocated chromosomes to achieve accurate mapping of breakpoints ranged from 2.5-fold to 6.2-fold.To speed up determination of the breakpoints from long-re... |
1870.In fact Sweden and Britain are surprisingly similar in the ratios and trends of net-exported energy at the three benchmarks; it seems the comparative advantages of energy-intensive production fell for these two countries over time.This is not surprising given dramatically falling transportation costs, which helped... | Previous research suggests that there is an inverted U-shape curve for energy intensity in the long-run for Western Europe with a peak in the early 20th century.This paper tests the hypothesis that the increase of German and British energy intensity was an effect from the concentration of heavy industrial production to... |
MSR, and are associated with significant Tl enrichment of the whole rock samples.High Tl concentrations in the background portions of samples U1301B 25R-1 123, 32R-3 50 and 36R-1 53 are associated with MSR at warmer temperatures consistent with modern basement conditions.These data indicate that Tl-uptake can be microb... | Hydrothermal circulation is a fundamental component of global biogeochemical cycles.However, the magnitude of the high temperature axial hydrothermal fluid flux remains disputed, and the lower temperature ridge flank fluid flux is difficult to quantify.Thallium (Tl) isotopes behave differently in axial compared to ridg... |
which includes site Work, Excavation & Backfill, Concrete, Roads, Parking, Walkways,Mechanical,Electrical assembly and wiring,Engineering and plant start-up,Capital costs of the MEA-based CO2 capture and compression system for NGCC, shown in Table 9, are not calculated and are based on costs provided by some of the aut... | This paper evaluates the effect of ambient conditions on a natural gas combined cycle power plant (NGCC) with CO2 capture and proposes design options for effective integration and off-design operation.In particular, the study assesses the effect of ambient temperature in the context of the electricity system in Mexico ... |
variations into account.For example, findings above might be useful in devising initiatives that are specifically oriented to different practices of drug diversion that arise in relation to different sources of supply and related acquisition strategies.It is worth reiterating that the study reported here was conducted ... | This article investigates everyday experiences and practises that are associated with processes of pharmaceuticalization and with practices of 'drug diversion'-that is, the illicit exchange and non-medical use of prescription drugs.It reports results from a qualitative study that was designed to examine the everyday di... |
site-directed mutagenesis of the terminal intronic dinucleotide AG to AA.Mutation at this site has a minimal effect on the sense transcript, introducing one nucleotide change to the 3′ UTR downstream of the FLC open reading frame.Multiple, independent transgenic lines containing either wild-type FLC or FLC carrying the... | We are investigating functionality of a setof long noncoding antisense transcripts, collectively called COOLAIR, produced at Arabidopsis FLOWERING LOCUS C ( FLC).We now show that splicing of COOLAIR is functionally important.The prp8 mutation perturbs a cotranscriptional feedback mechanism linking COOLAIR processing to... |
SwaI restriction sites.To analyze the effect of FLCtex seeds were collected from four homozygous plants of FLCtex/flc-2/prp8-6/FRI and five homozygous plants of FLCtex/flc-2/PRP8/FRI.These plants were obtained from the three independent crosses of FLCtex/flc-2/FRI to prp8-6/Ler.As a control for the FLCtex analysis, the... | COOLAIR initiates just downstream of the major sense transcript poly(A) site and terminates either early or extends into the FLC promoter region.The importance of COOLAIR splicing in this repression mechanism was confirmed by disrupting COOLAIR production and mutating the COOLAIR proximal splice acceptor site.© 2014 Th... |
mixture of AMAZ tablets, was present in all other samples, including the compressed AM.This difference, between the PXRD pattern of the compressed mixture tablets and the others, constituted the sole distinct feature within the observed patterns.In order to better understand this effect, a Rietveld refinement was perfo... | Artemether (AM) plus azithromycin (AZ) rectal co-formulations were studied to provide pre-referral treatment for children with severe febrile illnesses in malaria-endemic areas.The target profile required that such product should be cheap, easy to administer by non-medically qualified persons, rapidly effective against... |
overall quality of life could change over time during different stages of migration.It is important to appreciate and be sensitive of the personal factors an individual has that may impact on how they cope with migration and stuttering stress.A person shifting from one culture to another is likely to experience increas... | Purpose: Migration is a contemporary, global matter.With the number of international migrants doubling over the past four decades, speech-language pathologists will likely work with migrants who have childhood-onset stuttering.However, combined migration and stuttering experiences have never been investigated specifica... |
whose cost matrix is provided below Table 3).By solving transformed transportation problem P3 we can get the solution of the 3-dimensional,TP with bounds on availabilities, demand and different commodities.In this case, we find the solution of the related 3-dimensional transportation problem for impaired flow as follow... | In this paper, we consider a multi-index constrained transportation problem (CTP) of axial constraints with bounds on destination requirements, source availabilities, and multiple types of commodities.The specified problem is converted into a related transportation problem by adding a source, a destination, and a commo... |
of relapse after treatment of the primary tumor, especially in the absence of metastatic disease elsewhere.Lymphoscintigraphy studies for IBR performed on the patient before breast/axillary surgery have shown new drainage patterns to contralateral axilla.The real incidence of CAM is difficult to estimate.On one hand, t... | Introduction: Contralateral axillary lymph node metastases (CAMs) in patients with breast cancer are rare (Daoud et al., 1998); however, CAMs may be already detected at the time of primary breast cancer diagnosis (synchronous CAM) or after a previous treatment of breast cancer as a recurrence if not as an ipsilateral b... |
with these deviations being particularly evident at larger set sizes.Consistent with this model, we found evidence for non-normally-distributed errors in our location reproduction task.This neural model has the potential to provide an integrated account for the response latency and precision results in the present task... | Investigations of working memory capacity in the visual domain have converged on the concept of a limited supply of a representational medium, flexibly distributed between objects.The latter model makes the strong prediction that, if an item in memory is probed, behavioral parameters will plateau when the number of ite... |
Anandamide is a lipid neurotransmitter derived from arachidonic acid that inserts in the plasma membrane of target cells prior to exerting its biological effects .Therefore, the way AEA interacts with membrane lipids is of critical importance to understand its mechanism of action at the molecular level.Previous data sh... | Anandamide is a lipid neurotransmitter that interacts with various plasma membrane lipids.The data here consists of molecular dynamics simulations of anandamide, C18-ceramide and cholesterol performed in vacuo and within a hydrated palmitoyl-oleoyl-phosphatidylcholine (POPC)/cholesterol membrane.Several models of anand... |
Rab GTPases are the master regulators of vesicle-mediated membrane traffic and regulate almost every trafficking step involved in endocytosis and exocytosis.More than 60 Rab GTPases have been identified in mammals, forming the largest branch of the Ras-related GTPase.As with all GTPases, the function of Rab GTPases is ... | G-protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface signaling proteins.Here, we screen the TBC domain-containing proteins, putative Rab GTPase-activating proteins (GAPs), in the intracellular trafficking of GPCRs and identify several TBC proteins that activity-dependently regulate the... |
Golgi localization of Rab26 in cell, indicative of Rab26 inactivation.Second, TBC1D6 also markedly inhibited the activation-dependent interaction of Rab26 with the receptor.These data imply a possible molecular mechanism underlying the function of Rab26 and TBC1D6 in regulating GPCR cell surface trafficking, in which T... | However, the molecular mechanisms underlying their cell surface delivery after synthesis remain poorly understood.Furthermore, both overexpression and depletion of TBC1D6 inhibit the post-Golgi traffic of GPCRs.These data demonstrate important roles of the TBC proteins in forward trafficking of nascent GPCRs and reveal... |
the number of diesel-fuelled passenger cars increased by ~ 7.8 million.This trend has seen the relative proportion of diesel cars in the U.K traffic fleet increase from ~ 7% in 1994 to ~ 33% in 2012.The trend in the number of gasoline and diesel vehicles on the road is reflected in the volume of gasoline and diesel fue... | Vehicular emissions are a key source of polycyclic aromatic compounds (PACs), including polycyclic aromatic hydrocarbons (PAHs) and their oxygenated (OPAH) and nitrated (NPAH) derivatives, in the urban environment.Road tunnels are a useful environment for the characterisation of on-road vehicular emissions, providing a... |
method for comparison is confirmed here, Fig. 11.The simple beam tests can now also be used for obtaining material properties for design, when the data is analyzed using the nonlinear FE method.This article has focused so far on explaining the beam’s load deflection curves from the properties of the matrix.In many situ... | A novel method is proposed for interlaminar shear testing of marine composites, which accelerates fluid saturation: the I-beam short beam shear test.A layered finite element (FE) model is employed to explain the nonlinear behavior of the short beam shear experiment.Using this model, rectangular and I-beam short beam sh... |
agents.The notion of the logic of situation provides an interesting bridge between formal modeling and case study research.In principle, both should be contributions to the same project of theory development, but in practice the two communities seem to live in quite different worlds.8,Finally, the concern remains wheth... | Generalization from a case study is a perennial issue in the methodology of the social sciences.The case study is one of the most important research designs in many social scientific fields, but no shared understanding exists of the epistemic import of case studies.This article suggests that the idea of mechanism-based... |
was from 430.3 K to 1088.8 K using steps of 50 K. Each isothermal run consisted of 2–4 drops of Bi2UO6 samples, each surrounded by two drops of platinum from which the sensitivity of the device was determined.The drops were separated by time intervals of 20 min, long enough to re-stabilize the monitored heat flow signa... | In the frame of the safety of lead-bismuth eutectic cooled fast reactors, the thermal behaviour of bismuth(III) uranate(VI) was studied as a possible interaction product of the coolant and mixed oxide fuel.The heat capacity of Bi2UO6 were measured and presented here for the first time.The thermodynamic functions derive... |
and the antibodies concentration inside the sample, indicating that the herein proposed SPR based method can be successfully applied to detect and to quantify polyclonal antibodies in human serum specifically interacting with the immobilized glucopeptide antigen.The specific antibody reactivity of Multiple Sclerosis pa... | Abstract Surface plasmon resonance technique is particularly interesting in immunology because it has the potential to visualize label-free antigen-antibody interactions in real-time, thus enabling antibody detection and monitoring.Herein we release the guidelines for the correct use of a method to detect specific anti... |
directly involve women in male-headed households as input buyers so that they can identify their input needs.Limited access to land has a negative impact on women farmers’ uptake of CSA technologies, as customary laws deny them user rights and inheritance of farmland.Although legal documents allow women to access or us... | Although Climate-smart agriculture (CSA) can offer economic and food security opportunities for women farmers, success in the uptake of these technologies is contested by gendered constraints.Previous studies that use the household head as a unit of analysis to explain adoption patterns do not adequately demonstrate th... |
Fasciolosis caused by Fasciola hepatica, more commonly referred to as liver fluke, is a major cause of economic loss to the agricultural community worldwide as a result of morbidity and mortality in livestock.Verocytotoxigenic Escherichia coli O157 is a zoonotic bacteria of worldwide importance which, whilst largely as... | The parasite Fasciola hepatica is a major cause of economic loss to the agricultural community worldwide as a result of morbidity and mortality in livestock, including cattle.Cattle are the principle reservoir of verocytotoxigenic Escherichia coli O157 (VTEC O157), an important cause of disease in humans.To date there ... |
β = log, log, …, log, …, log, in each case with the maximum number of farms available for testing.In each case we recalculated the random-effects distribution parameters to match the marginal VTEC O157 farm-level prevalence.Power ranged from 13.0% to 99.6%.The power to detect an OR of 1.8 would be 75%.We considered all... | Pre-study sample size calculations are an important part of any study design.The framework developed here is applicable to the study of other co-infections. |
intercept and slope respectively.Table 2 depicts the maximum amount adsorbed, values of the rate constants and the correlation coefficients.The pseudo second order model is based on the assumption that the rate limiting step may be chemisorption which involves valence forces by sharing or electron exchange between the ... | This research work has proposed preparation of Zeolite/Zinc Oxide Nanocomposite (Zeolite/ZnO NCs) by using a co-precipitation method.Then, the prepared Nanocomposite has been tested for adsorption of Lead Pb (II) and Arsenic As (V) from aqueous solution under the room pressure and temperature.After that, the prepared a... |
Motor surround inhibition is a neurophysiological phenomenon that selectively facilitates the synergist muscles and inhibits the surrounding muscles to precisely execute a specific motor task .mSI is thought to be mediated by intracortical inhibitory mechanisms since patients with focal hand dystonia who exhibited redu... | Background: Motor surround inhibition (mSI) is a phenomenon supportive for executing selective finger movements, wherein synergist muscles are selectively facilitated while surround muscles are inhibited.Previous studies of conditioning inputs to several intracortical and cortico-cortical inhibitory networks did not sh... |
the study of insular hodology and the comparison with non-human primates.Notwithstanding these perspectives, as they stand, our maps provide only complementary information to parcellations based on cytoarchitecture, function, or hodology; they do not show direct associations or relationships.It is interesting that when... | The human insula is implicated in numerous functions.More and more neuroimaging studies focus on this region, however no atlas offers a complete subdivision of the insula in a reference space.The aims of this study were to define a protocol to subdivide insula, to create probability maps in the MNI152 stereotaxic space... |
of fungi associated with Norway spruce needles has been previously shown by different methods, and close to 100 species have been cultured.Fungal species that are expected to be common on Norway spruce needles include Lophodermium piceae, Rhizosphaera kalkhoffii, and Tiarosporella parca.L. piceae and R. kalkhoffii were... | Foliar fungal species are diverse and colonize all plants, though whether forest tree species composition influences the distribution of these fungal communities remains unclear.Fungal communities include quiescent taxa and the functionally important and metabolically active taxa that respond to changes in the environm... |
a virtual optomotor system to evaluate the optomotor responses.The original virtual optomotor system described by Prusky et al.23 was modified for rats.42,A light–dark grating pattern was projected onto a screen in front of a platform by using a projector."A video camera was stationed 50 cm above the platform to record... | We previously showed that blind rats whose vision was restored by gene transfer of Chlamydomonas channelrhodopsin-2 (ChR2) could only detect wavelengths less than 540 nm because of the action spectrum of the transgene product.We generated modified Volvox channelrhodopsin-1 (mVChR1), which is a chimera of Volvox channel... |
depression.Escaping mice had a resilience/susceptibility ratio which is significantly greater than that of Stay phenotype mice.In mice with the Stay phenotype, more time was spent near the empty container than near the social target, suggesting that Stay mice are susceptible to stress, anxious and depressive behavior.A... | Knockdown of orexin/hypocretin 2 receptor (Orx2) in the basolateral amygdala (BLA) affects anxious and depressive behavior.We use a new behavioral paradigm, the Stress Alternatives Model (SAM), designed to improve translational impact.The SAM induces social stress in adult male mice by aggression from larger mice, allo... |
Cereal is a collective term for grasses with grains used for nutritional purposes.Today they are a staple food all over the world with annual production exceeding 2.5 billion tons.The domestication of wild plants and the start of agriculture is regarded as one of the greatest and most important achievements in later hu... | The uptake of cereal agriculture in the Neolithic is one of the most important processes in later human prehistory.However, in many parts of Europe, early evidence from pollen or macrofossils is scarce or inconclusive, and there are considerable ambiguities about timing, intensity and the mode of transition to agricult... |
extraction of the lipids.Yet, analysis of samples from these pots showed that these measures did not have any notable effects and lipid concentrations were still <10 μg/g.Even refluxing cereals for 20 h in water released only little lipids to the cooking water.The amount of lipids which was extracted with DCM from the ... | For a better understanding of the behaviour of cereal lipids, cooking experiments were conducted and the uptake of cereal-specific compounds such as alkylresorcinols and plant sterols into the ceramic matrix was investigated using a new sensitive method based on GC-Q-ToF-MS.The cooking experiments showed that only smal... |
from the compost into the potsherd.The low degradation of plant sterols was rather surprising, since sterols are virtually absent in archaeological samples.In light of these results it appears more likely that sterols are degraded during the use of the pots instead of during post-use burial.Compared with sterols, alkyl... | Furthermore, changes in the lipid composition through post-burial degradation was assessed by incubation of potsherds dosed with cereal lipids at 35 °C in compost.Anoxic degradation conditions allowed for twentyfold higher levels of alkylresorcinols and twofold higher levels of plant sterols after 20 weeks compared to ... |
the nodule centres may be generated within the molten material by the gas pressure.The fractography of the coating formed in the aluminate-phosphate electrolyte reveals that the main crack propagated within the coating through a titanium-rich inner region.The scanning electron micrographs of Fig. 7 1 and indicate that ... | Two pre-treatments are compared, using aluminate-phosphate and silicate-phosphate electrolytes respectively, which result in different compositions and morphologies of coatings.The PEO-treated specimens revealed mainly cohesive failure within the titanium-rich inner coating regions, which contrasted with the adhesive f... |
to it can be put into a low-power mode to save energy.As in our experiments in Section 5, we assume a setting in which many VDCs will be allocated in consecutively.As we are considering repeated VDC allocation, at the beginning of each new allocation, each server may either already have some VMs assigned to it, or not.... | This paper considers the problem of virtual data center (VDC) allocation, an important, emerging challenge for modern data center operators.To address this problem, we introduce NETSOLVER, a system for VDC allocation that is based on constraint solving.NETSOLVER represents a major improvement over existing approaches: ... |
of a software to acquire and analyse data.The system is able to monitor H* and to provide activity concentrations of the different isotopes.Thus, it permits to detect and analyse small fluctuations of anthropogenic isotopes and to distinguish them from those from natural origin.When precise activity concentrations are ... | This paper presents the development, calibration and testing of a mobile unit for radioactivity monitoring.A 4 × 4 vehicle was equipped with a GPS and two 2″×2″ LaBr3(Ce) scintillation detectors.It was modelled using MC simulations with the EGS5 code to obtain efficiency curves for different source term scenarios.The a... |
period, 66,184 detections of the 34 paired individuals were recorded at the selective feeders, which occurred within 21,885 flocking events.Excluding associations between mated pairs, we calculated the proportion of each individual’s total associations to others who were allowed access to the same locations as themselv... | Social relationships are fundamental to animals living in complex societies [1-3].The extent to which individuals base their decisions around their key social relationships, and the consequences this has on their behavior and broader population level processes, remains unknown.Using a novel experiment that controlled w... |
Cardiovascular damage is one of the main concerns in the clinical management of chronic kidney disease.Indeed, CKD patients are exposed to a 2- to 4- fold higher risk of cardiovascular diseases than the general population and are more likely to die from CVD than from CKD .CVD incidence is not sufficiently accounted for... | The systemic role of the microbiota as a central player in the pathophysiology of many organs is progressively emerging in the literature: the microbiota is indeed involved in a complex, bi-directional network between many organs, including the kidney and heart connection, although many of these relationships still nee... |
was performed on a typical designed hanger steel structure, for which the height was varied from 5 m to 25 m.The structure was located in region 2 according to the map of France and assuming an exposed site according to NV65 standard and a category II terrain according to EN1991-1-4.The following conclusions were draws... | This paper presents a comparison between two standards, namely NF EN 1991-1-4/A1 (October 2010) of Eurocode 1 and NV65 (DTU P06-002) (February 2009), that estimate wind loads on steel structures.For that purpose, a typical steel hanger was designed and analysed using both standards.Five different heights for the design... |
cell with a 4 mm gap between the insulators) was compared to a parallel plate treatment chamber with a 4 mm electrode gap).All other parameters such as inlet velocity, viscosity, electric potential, pulse width, pulse repetition rate, and medium conductivity were kept equal for both treatment chambers.The results for t... | Pulsed electric field (PEF) is an emerging nonthermal technique with promising applications in microalgae biorefinery concepts.In this work, the flow field in continuous PEF processing and its influencing factors were analyzed and energy input distributions in PEF treatment chambers were investigated.Within the present... |
demanded by the decision-maker.However, increases in confidence levels and reductions in uncertainty will usually have resource implications in terms of updating and refinement of the model and, or the acquisition of better quality data from the real-world.Hence a cost-benefit analysis will often need to be performed.I... | Computational models in biology and biomedical science are often constructed to aid people's understanding of phenomena or to inform decisions with socioeconomic consequences.Model credibility is the willingness of people to trust a model's predictions and is often difficult to establish for computational biology model... |
Offset regression is a standard method for spatial localization in many vision tasks, including human pose estimation, object detection, and instance segmentation.However,if high localization accuracy is crucial for a task, convolutional neural networks will offset regressionusually struggle to deliver. This can be att... | We use mixture density networks to do full conditional density estimation for spatial offset regression and apply it to the human pose estimation task. |
both cases, this translates into additional investment.It plays a more important role for short-term applications and with larger quantities of storage deployed.Power to Gas has the main advantage of being able to produce different compounds and for different sectors.This gives more robustness to the technology as it p... | A review of more than 60 studies (plus more than 65 studies on P2G) on power and energy models based on simulation and optimization was done.Based on these, for power systems with up to 95% renewables, the electricity storage size is found to be below 1.5% of the annual demand (in energy terms).While for 100% renewable... |
criteria do not apply to small biomass-based heating/cooling and electricity installations, with a fuel capacity below 20 MW.Biogas production mainly from various waste and residues are favoured, due to its high capacity to deliver high GHG emission reductions.Biomethane is an energy carrier with a special value becaus... | This paper presents an overview of the development and perspectives of biogas in and its use for electricity, heat and in transport in the European Union (EU) and its Member States.Biogas production has increased in the EU, encouraged by the renewable energy policies, in addition to economic, environmental and climate ... |
Northern Eurasia is a large landmass with distinct gradients in climate.The last deglaciation led to dramatic changes to the Earth system, and in the North polar amplification likely enhanced regional responses to climate forcing.The geography of Eurasia altered dramatically as the extensive shallow coastal shelves bor... | Continental-scale estimates of vegetation cover, including land-surface properties and biogeographic trends, reflect the response of plant species to climate change over the past millennia.With the advent of transient and contiguous time-slice palaeoclimate simulations, vegetation datasets with similar temporal qualiti... |
in the east.When mapped in large numbers, the modern pollen data delineate major biomes and their ecotones relatively well.Error patterns are explainable by six factors that are not mutually exclusive: geographic proximity to other vegetation biomes; floristic similarity between pollen biomes; over-representation of wo... | An error matrix and index of topographic complexity clearly showed that the accuracy of pollen-based biome assignments (when compared with modern vegetation) was negatively correlated with topographic complexity, but modern vegetation was nevertheless effectively mapped by the pollen, despite moderate levels of misclas... |
the maps.A moderate drop in woody PFTs occurs in Europe during the 12.5 kyr cal BP time slice.This may reflect some retreat/thinning of forest cover during the Younger Dryas stade, which is expressed strongly in NW Europe but far more weakly with distance eastward from the Atlantic.At 12 kyr cal BP and in subsequent ti... | We collated fossil pollen records for the period 21,000–0 cal yr BP (kyr cal BP; calibrated ages) for Europe and Asia north of 40°N, using extant databases and new data; we filtered records for adequate dating and sorted the nomenclature to conform to a consistent yet extensive taxon list.From the onset of deglaciation... |
matches that of Willerslev et al., who proposed based on sedimentary DNA evidence, that forbs had an equal, if not dominant, role in full-glacial vegetation along with graminoids.Macrofossils also point to an important role for forb taxa in the full-glacial vegetation.The significance of this is yet to be fully investi... | These estimates can help assess the effectiveness of simulations of climate change using forward and inverse modelling approaches.PFT composition of the herbaceous biomes emphasises the significant contribution of diverse forbs to treeless vegetation, a feature often obscured in pollen records.14 kyr cal BP is suggeste... |
as reported in.Nevertheless, the small difference in performance means that the cheaper ENIG finish can be used, without much of a performance trade-off.On the other hand, the difference between the ENIG and hard Au finish on the rigid platforms was substantial.Platform 1 was fabricated by a different manufacturer from... | The measurement of Na+, K+ and H+ is essential in medicine and plays an important role in the assessment of tissue ischemia.Microfabrication, inkjet- and screen-printing can be used for solid contact ion selective electrodes (ISE) realization; these, however, can be non-standardized, costly and time consuming processes... |
and knowledge needed to support their employees’ motivation to innovate.We affirm Bell’s call for greater focus on “broad magnitudes and trends of the more important non-R&D components of innovative activity”, and policy discussion “about the kind of innovation capability that is created and accumulated”.From the persp... | Human capital, the set of skills, knowledge, capabilities and attributes embodied in people, is crucial to firms’ capacity to absorb and organize knowledge and to innovate.Research on human capital has traditionally focused on education and training.A concern with the motivationally-relevant elements of human capital s... |
to the same degree suggesting that the differential sensitivity of the C. albicans and S. cerevisiae is not due to differences in the direct action of PA on Fks1 activity.Combinatorial synergy between PA and cell wall synthesis inhibitors.PA could potentially be useful as part of a combinatorial therapy against Candida... | As with the echinocandins, such as caspofungin, PA targets the synthesis of cell wall β-1,3-glucan and has potential utility in the treatment of medically important fungi.These observations suggest that there are significant differences in the mode of action of PA and caspofungin and that PA or PA analogues are not lik... |
1 for their sensitivity to PA.The laboratory derived strains, fks1-S645S/P and fks1-S645P, were generated using CRISPR-CAS9 to introduce this point mutation.A heterozygous FKS1/fks1Δ null mutant was compared displaying marginally reduced sensitivity to PA and increased sensitivity to CSF.A variety of point mutations in... | However, the antifungal activity of PA against human pathogenic Candida species has not been explored and the precise mode of action of this compound is not understood.Strains with point mutations (S645Y or S645P) in the hotspot1 region of the β-1,3-glucan synthase subunit Fks1, had decreased sensitivity to caspofungin... |
α-actin and cytosolic γ-actin in KO cells does not functionally compensate for the loss of β-actin in mitochondrial quality control.In addition, only β-actin but not γ-actin was identified in isolated mtDNA, suggesting that the role in maintaining mtDNA transcription, mtDNA copy number, and MMP is specific for β-actin.... | In eukaryotic cells, actin regulates both cytoplasmic and nuclear functions.However, whether actin-based structures are present in the mitochondria and are involved in mitochondrial functions has not been investigated.Here, using wild-type β-actin +/+ and knockout (KO)β-actin −/− mouse embryonic fibroblasts we show evi... |
and education, and for elucidating how memory is supported in the adult brain.The past few decades have witnessed creative and ingenious ways of examining infants in order to appreciate what they are learning and if they remember, coupled with insights from surface ERP recordings of cortical responses.Models and testin... | Over the past 60 years the neural correlates of human episodic memory have been the focus of intense neuroscientific scrutiny.By contrast, neuroscience has paid substantially less attention to understanding the emergence of this neurocognitive system.In this review we consider how the study of memory development has ev... |
an explanatory variable in the models.The FID could not be short if passing distance was long, but FID could be either short or long with a short passing distance.For instance, the bear could leave before the observers were close to the initial site, which would cause a longer FID than if the bear leaves when the obser... | The proportion of bears that stayed or moved away from their initial site and their flight initiation distances did not increase or decrease with increasing number of encounters, and the bears' daily movement pattern changed consistently after each approach.Bears moved less during daytime for the next three days after ... |
had habituated after several frequent encounters, the initial bear reactions would have decreased as well, but this did not occur.When measuring and interpreting habituation or sensitization to disturbance, it is important to consider the intensity of the disturbance event.The less intense the stimulus, the faster and/... | Several large carnivore populations are increasing in human-dominated landscapes, but this good conservation news includes management challenges.We performed up to 8 experimental, repeated approaches on 29 radio-collared brown bears (Ursus arctos) in Sweden (195 approaches) to test if bears always avoided people or sho... |
different modes of transport.More detailed estimates of e.g. door-to-door travel times with a private car may be more difficult to obtain.Our example used travel time as the network measure to calculate accessibility.In some other cases, the physical distance, price of travelling or route quality/experience might be mo... | The concept of accessibility – the potential of opportunities for interaction – binds together the key physical components of urban structure: people, transport and social activity locations.Most often these components are dynamic in nature and hence the accessibility landscape changes in space and time based on people... |
Representations of sets are challenging to learn because operations on sets should be permutation-invariant.To this end, we propose a Permutation-Optimisation module that learns how to permute a set end-to-end.The permuted set can be further processed to learn a permutation-invariant representation of that set, avoidin... | Learn how to permute a set, then encode permuted set with RNN to obtain a set representation. |
polypeptides .A small number of components generated architectures of diverse shapes, including star and H-shaped.Sun et al. expanded this strategy to synthesise hydrogels .Mixing ELP fusions of two terminal SpyCatchers with terminally and internally fused SpyTags, robust protein matrices termed Spy networks form spont... | SpyTag is a short peptide that forms an isopeptide bond upon encountering its protein partner SpyCatcher.This covalent peptide interaction is a simple and powerful tool for bioconjugation and extending what protein architectures are accessible.Here we review the origin and mechanism of SpyTag/SpyCatcher, focusing on re... |
Meta-Reinforcement learning approaches aim to develop learning procedures that can adapt quickly to a distribution of tasks with the help of a few examples.Developing efficient exploration strategies capable of finding the most useful samples becomes critical in such settings.Existing approaches to finding efficient ex... | We propose to use a separate exploration policy to collect the pre-adaptation trajectories in MAML.We also show that using a self-supervised objective in the inner loop leads to more stable training and much better performance. |
Intravenous immunoglobulin is a plasma-derived therapeutic product used as antibody replacement therapy for patients with primary immunodeficiency disorders .PIDD patients are vulnerable to infectious pathogens; therefore, IVIG products contain different functional antibodies derived from many blood donors to ensure pr... | Patients with primary immunodeficiency disorders are vulnerable to infectious diseases.Intravenous immunoglobulin (IVIG) therapeutic products manufactured from human plasma are employed widely to protect patients from pathogens such as measles virus, which causes a potentially fatal and contagious disease.Therefore, he... |
by different ELISA assays based on relevant measles virus antigens.Three in-house ELISAs based on whole virus antigenic proteins or two well-known antigens that are important for neutralizing measles virus as well as five commercial ELISA kits were tested.All mnAb concentrations in final drug products and source plasma... | In general, mnAb titers are measured in a cell-based neutralization assay; however, this assay is labor intensive and time consuming, and the results are variable.Here, we compared a cell-based neutralizing assay with several ELISA tests to evaluate whether ELISAs can overcome the limitations of cell-based assays.The m... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.