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The dataset of this paper provides information related to the article “Application of three-dimensional collagen scaffolds to recapitulate and monitor the dynamics of epithelial mesenchymal transition during tumor satellite formation of head and neck cancer” .The background and characteristics of the cell lines of head... | Therefore, establishment of an in vitro system to monitor the phenomena is important to explicitly elucidate underlying mechanisms.This data presented here are referred to the research article (Chen et al., 2017) [1].Using this model, the dynamic process of tumor satellite formation could be recapitulated in different ... |
E-cadherin expression, which was compatible with the expression patterns demonstrated by the tumor mass in 3D culture systems.On the contrary, when tumor satellites were induced in the 3D culture system, E-cadherin expression changed from membranous patterns to cytoplasmic patterns.It was compatible with in vivo pathol... | Tumor satellite formation is an indicator of cancer invasiveness and correlates with recurrence, metastasis, and poorer prognosis.By analyzing pathological specimens, tumor satellites formed at the tumor-host interface reflect the phenomena of epithelial-mesenchymal transition.It is impossible to reveal the dynamic pro... |
VANETs with seamless connectivity, full coverage over the best available channels is required.At the moment, managing the overlapping signals of adjacent roadside units is one of the biggest challenges.In a comprehensive simulation study, Ghosh and his research team investigated “the feasibility and benefits of providi... | This article provides in-depth insights into the necessary technologies for automated driving in future cities.State of science is reflected from different perspectives such as in-car computing and data management, road side infrastructure, and cloud solutions.Especially the challenges for the application of HD maps as... |
than expected for simple additive stabilization by membrane and H-Ras binding.This observation suggests that the interaction between H-Ras and PI3Kα in the H-Ras-pYp-PI3Kα-PIP2 complex perturbs the optimal PI3Kα bilayer docking geometry achieved in the pYp-PI3Kα-PIP2 complex lacking H-Ras.Additional evidence for this p... | Cellular pathways controlling chemotaxis, growth, survival, and oncogenesis are activated by receptor tyrosine kinases and small G-proteins of the Ras superfamily that stimulate specific isoforms of phosphatidylinositol-3-kinase (PI3K).These PI3K lipid kinases phosphorylate the constitutive lipid phosphatidylinositol-4... |
The data contained 157 usable copies of questionnaires retrieved from 170 copies administered to consumers in Cape Town, South Africa; hence, representing a response rate of 92%.First, the researchers engaged in the data preparation process.According to Aaker et al. , data preparation is regarded as a process of conver... | This article presents raw inferential statistical data that determined the impact of exclusivity, materialism, perceived quality and brand consciousness on luxury consumption.The data were collected from consumers within the Cape Town metropolitan area.A quantitative research method was used to analyse the data.Structu... |
works within the interstices of affect, emotion and atmosphere to afford a more ‘care-full’ environment for the everyday experience of health and illness. "Drawing on our interviews as evidence, we can see that the Maggie's Centres charity points up the emotional consequences of cancer care environments as they are tod... | This article presents research on the architecture of Maggie's Centres, a series of buildings for those with cancer, their families and friends.In particular, we explore the way in which their architectural atmospheres are spoken of by architects who have designed individual Maggie's Centres, in interviews with staff m... |
mg kg−1, Cr mg kg−1 and Pb mg kg−1 in lower price lipstick have exceeded the mean ± SD concentration of Cd mg kg−1, Cr mg kg−1 and Pb mg kg−1 respectively in higher price lipstick.In addition, the mean ± SD concentration of Cu mg kg−1 in higher price lipstick is nearly the same as in lower price with mean ± SD concentr... | The cosmetics were digested and analyzed for heavy metals (manganese, nickel, copper, cadmium, chromium and lead) using atomic absorption spectrophotometer.The range of the concentrations in skin lightening creams is 4.90–24.51, 3.68–11.03, 4.24–8.48, 0.14–1.32, 0–0.05 and 0.05–0.14 mg kg−1 for Mn, Ni, Cu, Cd, Cr and P... |
AMP-activated protein kinase is the master regulator of cellular energy homeostasis, monitoring and responding to changes in the intracellular AMP/ATP ratio.AMPK signaling extends through a myriad of pathways and serves to replenish cellular ATP levels through down-regulation of anabolic pathways and up-regulation of c... | Summary 5-Aminoimidazole-4-carboxamide ribonucleotide (known as ZMP) is a metabolite produced in de novo purine biosynthesis and histidine biosynthesis, but only utilized in the cell by a homodimeric bifunctional enzyme (called ATIC) that catalyzes the last two steps of de novo purine biosynthesis.We go on to illustrat... |
of ZMP in mammalian cells is unlikely to be coincidental; this regulatory molecule potentially links histidine and de novo purine biosynthesis to AMPK signaling in cells.Further studies are required to fully decipher this regulatory role of endogenous ZMP in mammalian cells.Here, we have used the perquisite of ATIC dim... | ZMP is known to act as an allosteric activator of the cellular energy sensor adenosine monophosphate-activated protein kinase (AMPK), when exogenously administered as the corresponding cell-permeable ribonucleoside.Here, we demonstrate that endogenous ZMP, produced by the aforementioned metabolic pathways, is also capa... |
is normally sufficient to serve as a template for PCR analysis.Scratch off the leftover portion of the colony by another clean crystal tip and transfer all of the cells into a well of a 24-well culture plate with iPS cell medium containing Y-27632.Repeat the colony picking procedures to obtain as many clones as possibl... | Precise gene correction using the CRISPR-Cas9 system in human iPS cells holds great promise for various applications, such as the study of gene functions, disease modeling, and gene therapy.In this review article, we summarize methods for effective editing of genomic sequences of iPS cells based on our experiences corr... |
High-entropy alloys and compositionally complex alloys are a new class of multi-component metallic materials that have shown outstanding properties, sometimes surpassing conventional alloys and therefore sparking huge interest in the research community .Among the most promising candidates are two face-centered-cubic al... | The feasibility of engineering bimodal grain size distributions to achieve superior mechanical properties was explored in two face-centered cubic compositionally complex alloys, namely CrMnFeCoNi and its high-performance subvariant CrCoNi.Therefore both alloys were processed down to the nanocrystalline grain size regim... |
a novel non-histone basic protein named dinoflagellate/viral nucleoprotein that functions as a bulk protein for packing the genomic DNA .DVNPs originated from the algal virus protein EsV-152 .This discovery strongly suggests that dinoflagellates stopped using histones to package the DNA because they gained new proteins... | The nuclear structures of lower eukaryotes, specifically protists, often vary from those of yeasts and metazoans.Several studies have demonstrated the unique and fascinating features of these nuclear structures, such as a histone-independent condensed chromatin in dinoflagellates and two structurally distinct nuclear p... |
has only been available for the C-terminal chaperone domain .Of particular interest is the location and structure of the second transmembrane domain because of its overlap with SBDLI .Sequence based predictions for TM2 are inconsistent, however, predicting either residues ∼80–100 or ∼90–110, with some predictions being... | We report here a solution NMR study of a S1R construct (S1R(Δ35)) in which only the first transmembrane domain and the eight-residue N-terminus have been removed.The second transmembrane helix is found to be composed of residues 91-107, which corresponds to the first steroid binding domain-like region.The cytosolic dom... |
as an opsonin, where binding to virions can increase phagocytosis of MBL-coated viral particles, as has been shown for several viruses, including IAV, but not yet for IBV.In addition, MBL might enhance viral neutralization in vivo through the activation of complement via the lectin pathway, leading to enhanced influx o... | Mannose binding lectin (MBL) is a collagenous C-type lectin, which plays an important role in innate immunity.It can bind to carbohydrates on the surface of a wide range of pathogens, including viruses.Here we studied the antiviral effect of recombinant chicken (rc)MBL against Infectious Bronchitis Virus (IBV), a highl... |
central regulator of CNS spatio-temporal activation and energy expenditure).The number of cells in the LC, and concentration of NA in the brain, decrease during normal ageing, although more pronounced cell loss has been demonstrated in patients with AD. Thus, early degeneration of the LC and subsequent loss of NA-media... | The processes involved in the pathogenesis of AD have been shown to overlap with those found in cognitive decline in patients with Obstructive Sleep Apnoea (OSA).Adherence to treatment can, however, be an issue, especially in patients with dementia.Also, not all patients respond adequately, necessitating the use of add... |
undergoes oxidation during sample preparation.Finally, even in the case where neither donor nor acceptor concentrations are available, it is possible to recover variations in Kd and competitor concentrations across a sample.On the other hand, for a known Kd value in a bimolecular complex, and in the absence of competit... | Abstract FRET is widely used for the study of protein-protein interactions in biological samples.However, it is difficult to quantify both the FRET efficiency (E) and the affinity (Kd) of the molecular interaction from intermolecular FRET signals in samples of unknown stoichiometry.Here, we present a method for the sim... |
and metastasis .For instance, the expression of AREG in 4T1.2 breast cancer cells promoted cancer bone metastasis via decreasing osteoprotegerin secretion and inducing osteoclast differentiation .Amphiregulin promoted tumor proliferation, metastasis and angiogenesis in chondrosarcoma .In general, tumor invasion and met... | Human Amphiregulin (AREG) was found to be over expressed in many types of cancer patients including gastric cancer (GC).However, its role in GC development remained unknown.In this study, over expression of AREG in MGC803 and SGC7901 GC cells were conducted by gene transfection through utilizing gateway recombinant clo... |
Recent advances have illustrated that it is often possible to learn to solve linear inverse problems in imaging using training data that can outperform more traditional regularized least squares solutions.Along these lines, we present some extensions of the Neumann network, a recently introduced end-to-end learned arch... | Neumann networks are an end-to-end, sample-efficient learning approach to solving linear inverse problems in imaging that are compatible with the MSE optimal approach and admit an extension to patch-based learning. |
of kava, using both well-defined kava extracts and daily kavalactone dosages of less than 250 mg, have yet to identify any hepatoxicity issues, even when used daily for over a month.Similarly, in rats, long-term administration of kava, up to 380 mg/kg/day show lack of adverse liver effects.Higher dosages up to 2 g/kg o... | Ethnopharmacological relevance: Kava and kava extracts have shown great potential as a way to minimize anxiety-associated symptoms and to help alleviate pain.Hepatoxicity has been associated with the consumption of kava products.The chemical compounds, kavalactones (KL) and flavokavains (FK) have been implicated in kav... |
these gases.The comparison of net force clearly shows that the maximum molecular force significantly declines when the pure nitrogen is replaced by ammonia inside the domain.In addition, the maximum net force occurs in the vicinity of P = 400 pa for N2 while the maximum thermal stress for ammonia observed in low-pressu... | In order to simulate a rarefied gas inside the micro gas detector, Boltzmann equation is applied to obtain high precision results.This study performed comprehensive studies to reveal the main mechanism of force generation and applied this for the analysis of the gas mixture.Our findings show that value of generated Knu... |
whether the specified job task constituted an ergonomic hazard”.Laing et al., 2005 similarly provided training in these and other tools, including the Watbak biomechanical modeling software.However, as Haines and Wilson noted, the use of overly complex analytical tools may be counter-productive to the long-term viabili... | Participatory ergonomics programs have been proposed as the most effective means of eliminating, or redesigning, manual tasks with the aim of reducing the incidence of occupational musculoskeletal disorders.This review assesses the evidentiary basis for this claim; describes the range of approaches which have been take... |
health benefits.This finding also has implications for product development.It implies that crop breeding should emphasise traits that enhance positive experiences when eating OFSP foods.Third, we found that directing children to state their intention to eat the OFSP meal increased the actual proportion of this meal con... | This study investigated whether priming or self-generation of goals, or whether attention to instrumental or experiential goals together with use of a reminder condition or not, promotes dietary behaviour intentions and change.A set of 556 randomly selected children aged 7–12 in Osun state, Nigeria, participated in an ... |
Soilless plant culture is any method of growing plants without the use of soil as a rooting medium.This relatively simple definition encompasses a diverse range of plant growth systems which generally involves containerization of plant roots within a porous rooting medium known as a ‘substrate’ or ‘growing medium’.Comp... | However, increasing concern over the environmental impacts of some commonly used materials, has led researchers to identify and assess more environmentally sound alternatives.In response to the need for researchers to better identify promising new materials, we present an evidence-based argument for a more consistent a... |
materials like peat, the market value of component materials is just one of several factors which determine the relative economic cost of different soilless growing media.From a growing media manufacturer’s perspective, secondary processing costs, transport costs and the impacts of material selection on plant managemen... | Soilless cultivation is recognized globally for its ability to support efficient and intensive plant production.Until relatively recently, the main drivers for the selection of the component materials in growing media were largely based on performance and economic considerations.There has been an understandable focus o... |
The neurotrophin brain-derived neurotrophic factor is first translated as the precursor form, proBDNF.A common single nucleotide polymorphism rs6265 at codon 66 in the pro-domain of human proBDNF changes the amino acid sequence from the canonical sequence of valine to methionine.Whilst generally less prevalent, the Met... | Healthy young carriers of the Met66 form (present in ∼30% Caucasians) have reduced hippocampal volume and impaired hippocampal-dependent memory function, yet the same polymorphic population shows enhanced cognitive recovery after traumatic brain injury, delayed cognitive dysfunction during aging, and lower risk of late... |
which may act as a precursor to release of cytochrome C and caspase 3 cleavage, an event upstream of that assessed by the LDH assay.However, both Val66 and Met66 variants had similar effects, suggesting that this was not variant specific.The possibility that the Met66 variant may differentially affect neuronal plastici... | This study describes a fundamental functional difference between the two main polymorphisms of the pro-form of brain-derived neurotrophic factor (proBDNF), providing an explanation as to why these forms have such different age-related neurological outcomes.As anticipated, exogenous application of proBDNF Val66 to rat h... |
and asynchronous.It is difficult to identify maturation intermediates, and to distinguish intermediates that are on a productive assembly pathway from defective intermediates.This problem is further complicated because interfering with the timing of proteolytic cleavage, which would be essential in synchronizing or arr... | Retroviruses such as HIV-1 assemble and bud from infected cells in an immature, non-infectious form.Subsequently, a series of proteolytic cleavages catalysed by the viral protease leads to a spectacular structural rearrangement of the viral particle into a mature form that is competent to fuse with and infect a new cel... |
Invasive meningococcal disease caused by the bacterium Neisseria meningitidis is associated with high morbidity and mortality .Infants and children younger than 5 years of age have the highest incidence of IMD.Until recently, meningococcal serogroups B with 68.0% of IMD cases and C with 17.0% were the most prevalent in... | Methods: In the initial study (NCT00674583), healthy children, 2–10 years of age, were randomized to receive a single dose of either MenACWY-TT or MenC-CRM197.In the follow-up study, we present the persistence at 32, 44, 56, and 68 M post-vaccination, overall and stratified by age (2–5 and 6–10 years), and the immunoge... |
of assay variability, a common observation with functional assays such as the SBA assays, given that the M44 and M56 samples were tested at different times.In general, the decline in antibody levels following one dose of vaccine administration seems to be more pronounced when vaccination occurs in infancy and antibody ... | Background: We evaluated antibody persistence up to 68 months (M) post-vaccination with a quadrivalent meningococcal serogroups A, C, W and Y tetanus toxoid conjugate vaccine (MenACWY-TT) or a licensed monovalent MenC conjugate vaccine (MenC-CRM197) and subsequent booster responses to MenACWY-TT in healthy European chi... |
early involvement of a specialist thyroid multidisciplinary team when approaching a rare, clinically ambiguous scenario.It was eventually recommended that an aggressive surgical approach be adopted, given the patients young age and excellent premorbid condition.Such a strategy proved invaluable given the finding of sev... | Introduction: The approach to the anterior neck lump involves the consideration of numerous benign and malignant differentials.Presentation of case: We present a rare case of an occult papillary thyroid cancer with cystic nodal metastases presenting as a thyroglossal duct cyst.Discussion: We explore the literature surr... |
Learning to control an environment without hand-crafted rewards or expert data remains challenging and is at the frontier of reinforcement learning research.We present an unsupervised learning algorithm to train agents to achieve perceptually-specified goals using only a stream of observations and actions.Our agent sim... | Unsupervised reinforcement learning method for learning a policy to robustly achieve perceptually specified goals. |
In vanilla backpropagation, activation function matters considerably in terms of non-linearity and differentiability.Vanishing gradient has been an important problem related to the bad choice of activation function in deep learning.This work shows that a differentiable activation function is not necessary any more for ... | Iterative temporal differencing with fixed random feedback alignment support spike-time dependent plasticity in vanilla backpropagation for deep learning. |
per year, left for NOx and right for PM10.Data comes from 6 different studies concerning 9 ports: Barcelona, Genoa, Marseille, Venice, Thessaloniki and Izmir in the Mediterranean area, Samsun in the Black sea, and Tanjin and Qingdao in the Chinese Sea.All these studies calculate the engine energy output corresponding a... | NOx, SOx, PM and VOCs (Volatile Organic Compounds) are emitted by ships during manoeuvring in ports at arrival or departure and during hotelling when moored at wharves.In this paper data of NOx and PM10 emitted in port and traffic of passenger and commercial ships have been reviewed and critically analysed.All vessels ... |
and analyze the three ligands of higher binding affinity that were found to display higher binding affinity and common to the two receptors as shown in Fig. 5.The binding affinity, hydrogen bond, hydrophobic and electrostatic interactions of the three ligands having higher binding affinity with the two receptors were r... | A quantitative structural activity relationship (QSAR) study was performed on 50 compounds of NET inhibitors to investigate their inhibitory potencies against norepinephrine transporter as novel drugs for anti-psychotic disorders.The predictability and accuracy of the developed model was evaluated through external vali... |
purpose of exercises.Testing, assessing, and evaluating appeared to be the most common purpose of emergency exercises, with most of the exercises reportedly being designed to validate various emergency plans, both general and specific, as well as to test various protocols and procedures.Six exercises included in this r... | Health emergency preparedness exercises were found to be effective (post exercise) at improving participants’ knowledge of emergency activities, policies and procedures and improving overall competence and confidence.Other immediate individual benefits included improved perceptions of preparedness and improved understa... |
personal benefits from exercise participation have been reported, with evidence of positive post-exercise change in participants knowledge, perceptions and attitudes.This can be an indication of the exercises’ immediate positive effect.It has also been reported that individuals who participated in repeat tabletop exerc... | However, little is known about whether these exercises are effective at improving individual and/or organisational preparedness for responding to emergencies.This paper reviews and summarises published evidence on the effectiveness and benefits of exercises to prepare health emergency professionals for responding to em... |
of 7 may because of excited-state ICT .In the powdered state, compounds 4–7 also displayed good fluorescence emission property.The emission peaks of 4–7 were appeared at 532, 539, 549 and 562 nm, respectively.A slight red shift of the emission maximum of 4–7 is evident while moving from solution to the powdered state.P... | Four new donor–acceptor based stilbene derivatives were synthesized via Heck coupling reaction.These materials are green light emitters with good fluorescence quantum yield.Furthermore, the emitters show well matched HOMO/LUMO value as bipolar molecule.In addition, they are highly thermally stable.Optimized structures ... |
been accompanied by an increase in predatory extraction, provincial centralization of power, unbridled lack of accountability, and widespread rent-seeking by provincial elites.Two aspects highlighted in this paper doubtless deserve further study.This case study confirms the crucial role of intermediary actors – the “en... | With an estimated 10.6 million inhabitants in 2015 and an average 6.6% annual growth rate, Kinshasa ranks among the three largest cities in Africa and may well become the most populated.To cope with critically deficient water services, a local NGO supported by different donors has promoted decentralized water systems (... |
The animal world is replete with conspicuous forms, colours, and behaviours that seem at odds with maximizing survival.Darwin was the first to realize that the fitness costs of such traits could be outweighed by their positive effect on reproductive success .In contrast to individuals competing for resources, which is ... | A main mechanism of lateral gene transfer in bacteria is transformation, where cells take up free DNA from the environment which subsequently can be recombined into the genome.Bacteria are also known to actively release DNA into the environment through secretion or lysis, which could aid uptake via transformation.Speci... |
rates .In animals as well as in other organisms, sexual selection theory has been extremely successful in explaining morphologies and behaviours that do not make sense from the point of natural selection.Although terms such as ‘assortative mating’ and ‘mate choice’ have been used in the literature on bacterial transfor... | Various evolutionary benefits of DNA uptake and DNA release have been proposed but these have all been framed in the context of natural selection.Here, we interpret bacterial DNA uptake and release in the context of sexual selection theory, which has been central to our understanding of the bewildering diversity of tra... |
At a global scale, China is the largest exporter of medicinal plants, the majority of which are wild harvested, often unsustainably.Several examples of unsustainable wild harvest, such as of Fritillaria cirrhosa D. Don and Paris polyphylla Smith are given in this special issue.In contrast, this study evaluates the outc... | Ethnopharmacological relevance: Endemic to China, the distribution of Schisandra sphenanthera Rehder & E.H. Wilson includes giant panda (Ailuropoda melanoleuca David, 1869) habitats in forests of the Minshan and Qinling Mountains, both inside and outside conservation areas.The fruit is used in indigenous medicines of t... |
announcing the application of the new Chinese standard for sustainable panda friendly wild collected southern schisandra fruit.At the time of this research, public events to officially announce the new Chinese standard, jointly organised by CNCA and WWF-China, were being planned to occur during the 2018 schisandra frui... | Also used in traditional Chinese medicine (TCM), indications for use are prescribed in the Chinese Pharmacopoeia.Aims of the study: This study aimed at assessing the project activities, institutional-level outcomes and achievements, 10 years on, of the 5-year (2007–2011) UNDP- and WWF- supported EU-China Biodiversity P... |
secondary instabilities of a highly sheared lee wave developed over an abrupt obstacle.Their results highlighted the importance of abrupt topographies in developing hydraulic control points at lower Froude numbers than more rounded obstacles.We propose that the ubiquity of the near-N waves in our observations is a dire... | Oceanographic observations were made with a subsurface oceanographic mooring over the summit and flanks of two neighbouring seamounts in the tropical Indian Ocean to identify processes that may be responsible for the aggregation of silvertip sharks (Carcharhinus albimarginatus) in the deep water drop-off surrounding th... |
shows that at the same flow rate, Q = 6 mL/min, the recoiling rate for solution of C12TAB is slower than that of water with recoiling rate ratio being ∼ 1.4.At the same time the thinning of the secondary neck also slows down due to smaller capillary pressure in the surfactant solution.The time between the primary and s... | Attention is paid to two transitions: (i) between regimes with and without satellite droplet formation and (ii) from dripping to jetting.Critical Weber number for transition to the regime without satellite droplets depends noticeably on the liquid surface tension and therefore cannot be used as a single parameter chara... |
allow researchers to investigate the causal effects of maternal alcohol use during pregnancy.In summary, this review helps to address a gap in the literature by systematically reviewing and describing published research on intrauterine alcohol exposure and offspring mental health for all ages above 3.We found evidence ... | Background: High levels of alcohol use in pregnancy have been shown to be associated with negative physical health consequences in offspring.However, the literature is less clear on the association of alcohol use in pregnancy and offspring mental health, specifically for low levels of prenatal alcohol exposure.We condu... |
leading to a stronger adhesion.On the other hand, our predicted dadh for Ti seems to deviate from the optimal one, leading to a weaker adhesion.We note that the present work did not take explicitly into account the energy loss/gain by the lattice relaxation.The metallic ion is located just above the carbon atom in our ... | We explore possible candidates for metallic electrodes of diamond semiconductor from twenty kinds of metallic sheets on oxygen- or hydrogen-terminated diamond (111) surface as well as pristine one.Their adhesion strengths and electric characteristics of contacts (i.e.either Ohmic, Schottky or neither) are both consider... |
Benthic foraminifera are valuable biological indicators of environmental change, particularly with respect to sea level and water quality.The utility of benthic foraminifera as bioindicators is largely due to their high taxonomic diversity and abundance; narrow ecological specificity; excellent preservation potential; ... | Declining water quality represents a major threat to the coral reefs of Australia's Great Barrier Reef (GBR).Due to their close proximity to river point sources, reefs situated on the inner-shelf of the GBR are widely perceived to be most susceptible to the increased discharge of nutrients and sediments from coastal ca... |
their original article, Hallock et al. recognised the requirement for the refinement of the FI to local conditions outside of the Caribbean.In this respect, a taxon of particular interest within nearshore turbid-zone settings on the central GBR is Pararotalia spp., which contributed most to the observed dissimilarities... | Rather, we interpret changes in the composition of benthic foraminiferal assemblages as being linked to changes in hydrodynamic energy, light availability and the carbonate content of reef-matrix sediments during reef shallowing towards sea level. |
Human neutrophil elastase, a serine protease secreted by polymorphonuclear neutrophils, plays an important role in many physiological and pathological processes."The proteolytic activity of this enzyme contributes to the body's defence against infectious agents by promoting the destruction of pathogenic bacteria.High l... | Human neutrophil elastase (HNE) is a serine protease, produced by polymorphonuclear neutrophils (PMNs), whose uncontrolled production has been associated with various inflammatory disease states as well as tumour proliferation and metastasis.Here we report the development and characterisation of an electrochemical pept... |
sensing platform was assessed in terms of selectivity towards HNE in comparison with potential interferences from real samples.Both substrate and control-modified surfaces were exposed to different solutions containing cathepsin G, a serine protease also present in PMNs; BSA and casein as means of evaluating non-specif... | The sensing platform was characterised in terms of its analytical performance, enzymatic cleavage kinetics and cross-reactivity and applied to the quantitative detection of protease activity from PMNs from human blood. |
of courseware of the MAGICS materials software workshop.All training modules and courseware materials are freely distributed from the MAGICS website to create an open educational platform for future computational researchers.In summary, RXMD is a scalable and portable parallel RMD simulator specifically designed to per... | RXMD is a parallel reactive molecular dynamics (RMD) simulator designed to perform large-scale RMD simulations on commodity laptop computers to supercomputer platforms.With extensive Time-to-Solution (TtoS) optimization techniques and scalable algorithms implemented, RXMD enables researchers to explorer materials desig... |
mol toluene would be required thermodynamically.To allow for higher toluene conversions either lower temperatures or a higher excess of perhydro-dibenzyltoluene would be required.Due to the weak exothermicity the effect of temperature on equilibrium is rather small.Thus, reduction of temperature for thermodynamic reaso... | We here demonstrate that the hydrogen-rich form of the LOHC system dibenzyltoluene/perhydro-dibenzyltoluene can be directly applied as sole source of hydrogen in the hydrogenation of toluene, a model reaction for large-scale technical hydrogenations. |
this variant was identified in another PPCD-affected individual, suggesting that this is a recurrent mutation.Two further unique variants were found in intron 1 of GRHL2 in additional unrelated individuals affected with PPCD.All three GRHL2 mutations were located in a conserved uncharacterized regulatory region.We hypo... | In a large family of Czech origin, we mapped a locus for an autosomal-dominant corneal endothelial dystrophy, posterior polymorphous corneal dystrophy 4 (PPCD4), to 8q22.3–q24.12.Targeted sequencing identified the same variant in three additional previously unsolved PPCD-affected families, including a de novo occurrenc... |
application case should therefore be investigated beforehand.A known fact is that there is a larger chance of solid formations at lower temperature levels and the potential benefits of adding CO2 will therefore be smaller.It should also be noted that the calculations were pushing the reported limits of the models, arou... | Upgrading waste heat by compression resorption heat pumps (CRHP) has the potential to make a strong impact in industry.The efficiency of CRHP can be further improved by using alternative working fluids.In this work, the addition of carbon dioxide to aqueous ammonia solutions for application in CRHP is investigated.The ... |
This paper concerns dictionary learning, i.e., sparse coding, a fundamental representation learning problem.We show that a subgradient descent algorithm, with random initialization, can recover orthogonal dictionaries on a natural nonsmooth, nonconvex L1 minimization formulation of the problem, under mild statistical a... | Efficient dictionary learning by L1 minimization via a novel analysis of the non-convex non-smooth geometry. |
Traumatic brain injury is the leading cause of death and disability in young adults in the United States .It accounts for approximately 2.8 million annual visits to the emergency department, hospitalizations, and deaths .In recent years, TBI has gained recognition as an acute trauma that can progress into a chronic dis... | Traumatic brain injury (TBI) is a major cause of death and disability worldwide.Recent efforts have focused on identifying potential therapeutic targets that underlie the secondary TBI pathology that evolves minutes to years following the initial injury.Oxidative stress is a key player in this complex cascade of second... |
apocynin can limit the extent of TBI, a targeted approach to deliver apocynin to a limited tissue area or organ may be optimal to limit suppression of physiological NOX signaling.Cell-specific targeting of NOX inhibitors, towards activated pro-inflammatory microglia for example, may also provide yet another approach th... | Despite intense investigation, no neuroprotective agents for TBI have yet translated to the clinic.Human post-mortem and animal studies have identified elevated NOX2 and NOX4 levels in the injured brain, suggesting that these two NOXs are involved in the pathogenesis of TBI.Finally, the translational potential, caveats... |
to the accuracy of gauges and GPS buoys which are regularly used for calibration of satellite altimetry, but a systematic bias may be present.The spatial resolution and measurement setup of the dataset used here is far from optimal, nevertheless the resulting dataset is of satisfactory accuracy.Generally, in addition t... | Recent developments in satellite altimetry are leading to improved spatial resolution, allowing applications in the coastal zone and over inland waters.Validation of these sensors near the shore remains a challenge, since the process of upscaling from single point measurements (gauges or GPS buoys) to the radar altimet... |
limitations of small-scale aquaponics.In a survey of commercial aquaponics operators, those in temperate to warm climates were four times as likely to be profitable as those in colder climates, suggesting that heating costs could be a constraint.Over 70% of commercial systems are sited in a greenhouse or use a greenhou... | Comparing inputs to outputs, 104 L of water, 0.5 kg feed, and 56 kWh energy ($6 in energy costs) were needed to produce 1 kg of crops; and 292 L of water, 1.3 kg feed, and 159. kWh of energy ($12 in energy costs) were needed to produce a 1 kg increase in tilapia. |
was less than the energy costs for raising the fish.A recent case study of small scale aquaponics in Hawaii had lower input costs for producing fish than in Baltimore, with a total costs $4.80/kg and $1.70/kg from energy costs, which can be attributed to the warmer climate in Hawaii.The sales price for tilapia in the H... | Aquaponics is a form of aquaculture that integrates hydroponics to raise edible plants and fish.There is growing interest in aquaponics because it can be practiced in non-traditional locations for agriculture such as inside warehouses and on marginal lands, and it can provide locally grown products without using synthe... |
of implant within the implant site to that seen with X-ray segmentation, comparison of the scores for the 3 materials at each time point did not reach statistical significance.Fig. 6 shows mosaic histological images of cross-sections of the implant sites for a 6 week polymer, 24 week microcomposite and 24 week nanocomp... | This paper reports the effect of particle size within a resorbable composite on the in vivo degradation rate and host response.An intimate interface was observed between the new bone tissue and degrading implants.Visual scoring of histological images and semi-automated segmentation of X-ray images were used to quantify... |
in O2 concentration that inhibited nitrogenase and during which previously available fixed nitrogen became depleted.Exactly this pattern is reported in a modern microbial mat during the natural diel cycle .In these observations, and following the onset of illumination, increased oxygen inhibits both nitrogenase activit... | Cyanobacteria produced the oxygen that began to accumulate on Earth 2.5 billion years ago, at the dawn of the Proterozoic Eon.By 2.4 billion years ago, the Great Oxidation Event (GOE) marked the onset of an atmosphere containing oxygen.The oxygen content of the atmosphere then remained low for almost 2 billion years.Wh... |
Response of microalgae to environmental stimuli is species-specific and may even vary from strain to strain .Moreover, mangrove dwelling microalgae are often exposed to impending high and low tides making them unique assemblages in a marginal ecosystem niche with possibly unique responses.Being able to regulate and exe... | Interest in harvesting potential benefits from microalgae renders it necessary to have the many ecological niches of a single species to be investigated.This dataset comprises de novo whole genome assembly of two mangrove-isolated microalgae (from division Chlorophyta); Chlorella vulgaris UMT-M1 and Messastrum gracile ... |
patients with concomitant sepsis suggesting a possible contribution of this population to susceptibility and/or impaired immune responses to infection episodes.Therefore, monitoring the expansion of this CD8+ T cell subset could serve as a potential immunomodulatory marker to facilitate the discrimination of cirrhotic ... | Background: Cirrhosis-associated immune dysfunction (CAID) contributes to high sepsis risk in patients with chronic liver disease.Various innate and; to a lesser extent; adaptive immune dysfunctions have been described as contributors to CAID leading to immune-paresis and impaired anti-microbial response in cirrhosis.I... |
Metals are necessary components of all ecosystems and occur naturally in the earth's crust.They appear in a wide range of oxidative states and coordination numbers, influencing their chemical characteristics and thus their bioavailability and toxicity.Certain metals such as iron, copper and zinc are considered essentia... | Recent studies have shown that metals such as copper, zinc, aluminum, cadmium, chromium, iron and lead cause severe dose-dependent disturbances in growth, morphogenesis, photosynthetic and respiratory activity as well as on ultrastructure and function of organelles in the algal model system Micrasterias denticulata (Vo... |
to compensate the impact of Pb on short-term treated Micrasterias cells, while Gd, a well-known Ca2+ channel blocker has no ameliorative effects.This indicates that Ca2+ channels are not involved in the uptake and toxicity mechanisms of Pb in Micrasterias, even though they have been described as possible influx sites f... | In the present investigation we focus on amelioration of these adverse effects of cadmium, chromium and lead by supplying the cells with different antioxidants and essential micronutrients to obtain insight into metal uptake mechanisms and subcellular metal targets.This seems particularly interesting as Micrasterias is... |
The goal of antiretroviral therapy for people infected with HIV is to achieve and maintain continuous maximal virological suppression to allow immune reconstitution, minimise the risk of resistance emergence,1–4 prevent HIV-related morbidity and mortality, and to prevent transmission.1–9,Most people starting treatment ... | Methods The UK Collaborative HIV Cohort (UK CHIC) Study is an ongoing multicentre cohort study that brings together in a standardised format data on people with HIV attending clinics around the UK.Viral rebound was defined as the first single viral load of more than 200 copies per mL or treatment interruption (for ≥1 m... |
first of two consecutive viral load measurements of more than 200 copies per mL, including treatment interruption; and without censoring follow-up when a gap in viral load measurements of more than 12 months occurred.Poisson regression was used to identify factors potentially associated with viral rebound.Follow-up was... | We included participants who started ART with three or more drugs and who had achieved viral suppression (≤50 copies per mL) by 9 months after the start of ART (baseline).Results Of the 16 101 people included, 4519 had a first viral rebound over 58 038 person-years (7.8 per 100 person-years, 95% CI 7.6–8.0).Of the 4519... |
living in sub-Saharan Africa, because the lower socioeconomic conditions and greater hardships resulting from taking time from work and getting to a clinic in these settings might mean that rebound rates would be higher than in our study.24–26,However, the proportion of people reported to be on ART and to have viral lo... | Background The length of time that people with HIV on antiretroviral therapy (ART) with viral load suppression will be able to continue before developing viral rebound is unknown.We aimed to investigate the rate of first viral rebound in people that have achieved initial suppression with ART, to determine factors assoc... |
in the LV network losses.The mean MAPE and the overall maximum absolute percentage errors of the estimated voltage angles are shown in Fig. 15.Fig. 15 shows that although the increase in the level of uncertainty in LV network losses is accompanied with an increase in the errors of estimated voltage angle, however, the ... | Distributed generation and low carbon loads are already leading to some restrictions in the operation of distribution networks and higher penetrations of e.g.In order to manage the distribution network effectively in this new situation, increased real-time monitoring and control will become necessary.In the future, dis... |
and co-workers .In this study, they proposed a Z-scheme PEC cell based on p-Si photocathode modified with Cu nanoparticles and TiO2 photoanode for CO2 reduction.Several products were also observed such as hydrogen, CO, CH4, C3H6, C3H8, C4H8 and C4H10.However, the presence of Cu improved the selectivity of the system.Sp... | A promising strategy to mitigate both energy shortage and global warming is the conversion of CO2 into chemicals that can be used as fuels (chemical fuels) by utilizing renewable energy sources.Up to date, solar-driven CO2 reduction has been achieved with photochemical (PC) and photoelectrochemical (PEC) systems or ele... |
Despite their popularity and successes, deep neural networks are poorly understood theoretically and treated as 'black box' systems.", 'Using a functional view of these networks gives us a useful new lens with which to understand them.This allows us us to theoretically or experimentally probe properties of these networ... | A functional approach reveals that flat initialization, preserved by gradient descent, leads to generalization ability. |
in the OpenSees code.2D tapered and non-tapered PPS piers are statically and dynamically analysed and the influence of key parameters is investigated.A conventional CIP pier is also analysed, and compared to its corresponding PPS counterpart.The results of pushover analyses showed that higher axial load ratio, post-ten... | Accelerated Bridge Construction (ABC) philosophy has resulted in extensive developments of precast post-tensioned segmental (PPS) bridge piers in the bridge construction.Currently, there is a significant paucity in the literature on nonlinear mechanics and dynamics of PPS piers.Hence, this wok numerically investigates ... |
forest captured with similar flight parameters.Novel hyperspectral imaging technologies are of interest also in other types of complex scenes, such as urban scenes, tropical forest, mountains or glaciers.Previous studies have shown that the geometric processing based on the structure-from-motion-technique or bundle blo... | A recent revolution in miniaturised sensor technology has provided markets with novel hyperspectral imagers operating in the frame format principle.In the case of unmanned aerial vehicle (UAV) based remote sensing, the frame format technology is highly attractive in comparison to the commonly utilised pushbroom scannin... |
semantically, as Ligra states in , the function provided to edgeMap ”can run in parallel, so the user must ensure parallel correctness”.In other words, the user is in partially responsible for the thread-safety of Ligra.In addition, the iterative structure of the computation as well as dynamic memory allocations and de... | Multiple shared memory frameworks that have implemented the vertex-centric interface all expose a common tradeoff: programmability against memory efficiency and performance.Our approach consists in preserving vertex-centric programmability, while implementing optimisations missing from FemtoGraph, developing new ones a... |
as expected or anticipated resulted in the need to plan certain activities to promote healthy behaviours, operationalize some health programmes and fill some action-planning gaps.Even if in this study it remained unclear what emerged first, peer intersectoral collaboration is required to cope with diabetes holistic con... | Background Diabetes has become a challenging health priority globally.However, little is known about how this is happening in practice in Europe.Objectives To explore diabetes self-management interventions undertaken or promoted by voluntary organisations and community groups in Europe; and describe the types of workin... |
the experimental data obtained show that when no jet is blowing in the bump valley, the spanwise and streamwise flow pattern appeared over the bump were similar to those shown in the plain bump.In fact, the sizes of the wake region and the spanwise vortices that formed in the valley of the active jet bump without jet b... | Streamwise and spanwise flow pattern over three rounded contour bumps with different flow control strategies employed have been experimentally investigated in a Mach 1.3 freestream.Surface oil flow visualisation, Schlieren photography and particle image velocimetry measurements were used for flow diagnostics.Experiment... |
thought to reflect the presence of a proportion of the neutralising epitopes on VP2, that are conserved or shared between different BTV serotypes .Earlier studies have reported low-level or one-way serological cross-reactions between different BTV serotypes in cross neutralisation and cross-protection studies, that ref... | Bluetongue is a severe, economically important disease of ruminants that is widely distributed in tropical and temperate regions around the world.Mammalian hosts infected with bluetongue virus (BTV) generate a protective neutralising antibody response targeting the major BTV outer-capsid protein and serotype-specific a... |
Given samples from a group of related regression tasks, a data-enriched model describes observations by a common and per-group individual parameters.In high-dimensional regime, each parameter has its own structure such as sparsity or group sparsity.In this paper, we consider the general form of data enrichment where da... | We provide an estimator and an estimation algorithm for a class of multi-task regression problem and provide statistical and computational analysis.. |
The presented map represents the extent of total grassland and permanent grasslands) for Switzerland for the year 2015.The comparison between the presented grassland map with digital orthophotos for 1000 random points reveals a mapping accuracy of grassland by 82.1%.The remaining of non-matching points is bedrock which... | So far, neither a grassland map, temporal analysis of the conversion of permanent grassland (PG) to other land uses nor the differentiation of permanent and temporal grassland exists for Switzerland.For the first time in Switzerland, we present a Swiss national grassland map for the year 2015 capturing the extent of bo... |
The data in the PRIDE Archive provide a comprehensive protein identification of different stages of peanut gynophores .This data can be analyzed using a variety of commercial tandem mass spectrometry tools.The data provide variable information for researchers to study the functions of potential key genes in peanut pod ... | Different from most of other plants, peanut (Arachis hypogaea L.) is a typical geocarpic species which flowering and forming pegs (gynophores) above the ground.Pegs penetrate into soil for embryo and pod development.To investigate the molecular mechanism of geocarpy feature of peanut, the proteome profiles of aerial gr... |
Tci-CF-1 may have a similar immunomodulatory function.Tci-CF-1 and FheCL have been tested in trials, which showed significant levels of protection against T. circumcincta in lambs, as part of the eight-protein “cocktail”, and F. hepatica in calves, respectively.Rab GTPases represented 6% of the proteins found in the EV... | The development of high levels of anthelmintic resistance in this nematode species challenges its future control.Recent research indicates that many parasite species release extracellular vesicles into their environment, many of which have been classified as endocytic in origin, termed exosomes.These vesicles are consi... |
provides a promising and systematic way to design mechanically robust hydrogels, and can be applied to a variety of different fibre-matrix material systems.In this work, novel nanocomposite structures were generated using laminated and non-laminated electrospun gelatin nanofibres in an alginate hydrogel matrix.The comp... | Mechanically robust hydrogels are required for many tissue engineering applications to serve as cell-supporting structures.Unlike natural tissues, the majority of existing tough hydrogels lack ordered microstructures organized to withstand specific loading conditions.In this work, electrospun gelatin nanofibres, mimick... |
crossing the Fermi level EF confirm metallic characteristics of the synthesized compound under study.We see more number of energy bands had been crossed the Fermi level and the dispersion at X point along high symmetry direction was higher than that of the previous reported band structure .It might be due to accuracy o... | The contribution of O-2p orbital electrons at the EF is higher than those of other orbital electrons as seen from partial density of states.The valence electron charge density map shows the isotropic nature of charge distribution.Coexistence of electron and hole like pockets form the multi sheets Fermi surfaces and exh... |
calculated by using bulk modulus and share modulus .Thus Debye temperature and bulk modulus are intimately related to each other.We see that the bulk modulus and Debye temperature at a specific pressure is not significantly changing in the low temperature range up to 100 K but linearly decreasing with increasing temper... | A new simple cubic perovskite superconductor (Ba0.62K0.38)(Bi0.92Mg0.08)O3 with a Tcmag ∼30 K has been recently synthesized by utilizing facile hydrothermal conditions at 220 °C.The calculated elastic constants satisfy the Born mechanical stability criterion.Based on the calculated data of Cauchy pressure, Pugh ratio a... |
stage 28 did not beat when analysed at stage 40.Instead of a compact structure that forms from control transplants, stage 28 transplants were looser with evidence of extensive cell migration into the host embryo.The loss of capacity to generate a SH is likely to be an intrinsic property of stage 28 GATA4-expressing tra... | The mechanisms that govern specification of various cell types that constitute vertebrate heart are not fully understood.Whilst most studies of heart development have utilised the mouse embryo, we have used an alternative model, embryos of the frog Xenopus laevis, which permits direct experimental manipulation of a non... |
Buruli ulcer is caused by Mycobacterium ulcerans.The infection is characterised by painless cutaneous lesions leading to scarring, contracture deformities, amputations, and disabilities if left untreated.1,Despite its discovery more than a century ago and its spread since the 1980s, Buruli ulcer remains one of the most... | Background: Buruli ulcer is the third most common mycobacterial disease worldwide.The public health burden of this neglected tropical disease is large, particularly in poor areas of west and central Africa.Interpretation: This study opens up new possibilities for developing an effective yet affordable policy to fight t... |
but precise knowledge of the ecology and transmission routes of the causal microorganism is required.23–26,The beneficial effect of access to protected water sources has been established for several water-borne diseases, which are a major cause of morbidity and mortality worldwide.However, few studies have assessed the... | The development of appropriate preventive strategies is hampered by an incomplete understanding of the epidemiology and transmission of the disease.Methods: In this case-control, quantitative survey, we obtained field data for Buruli ulcer incidence over a 10-year period from a specialised centre that collected data fo... |
slowed and the number of new cases stabilised.By contrast, the number of new cases in Plateau remained low and stable, and thus displayed a different pattern of change over the 2006 to 2015 period.The Ouémé and Plateau departments are covered by the CDTLUB-Pobè.Between 2006 and 2015, the hospital diagnosed and treated ... | We investigated the effect of the drilling of wells on Buruli ulcer incidence.A case-control study was then done to investigate the role of well water use in protecting against Buruli ulcer.Findings: We found a strong inverse correlation between the incidence of Buruli ulcer and the number of new wells drilled in the B... |
important insights to inform this debate when they report later this year.If aspirin were proven to provide little additional benefit to strong P2Y12 blockade, then drugs such as prasugrel or ticagrelor alone could become standard of care.DAPT could then become third generation P2Y12 antagonist plus another drug, perha... | For many millions of patients at secondary risk of coronary thrombosis pharmaceutical protection is supplied by dual anti-platelet therapy.Despite substantial therapeutic developments over the last decade recurrent thrombotic events occur, highlighting the need for further optimisation of therapies.Importantly, but oft... |
pre-culture grown in Sauton medium.After 7 days of static growth at 37°C, the culture was split into two aliquots, and 11426026 was added to one and DMSO to the other as a control.After 1 hr, uracil was added to a final concentration 1 μCi/ml.Radiolabeling was carried out for 3 hr, then two 2-ml batches were removed fr... | Summary To combat the emergence of drug-resistant strains of Mycobacterium tuberculosis, new antitubercular agents and novel drug targets are needed.Phenotypic screening of a library of 594 hit compounds uncovered two leads that were active against M. tuberculosis in its replicating, non-replicating, and intracellular ... |
The domain of time-series forecasting has been extensively studied because it is of fundamental importance in many real-life applications.Weather prediction, traffic flow forecasting or sales are compelling examples of sequential phenomena.Predictive models generally make use of the relations between past and future va... | In order to forecast multivariate stationary time-series we learn embeddings containing contextual features within a RNN; we apply the framework on public transportation data |
cover percentage between maps and official statistics.Municipalities with a very low crop cover were excluded from the analysis to avoid the influence of other factors.These plots show a moderate relationship that over-estimation is more likely to occur in flatter areas, which is consistent with our observations.In Bra... | For the two of the most important agricultural commodities, soybean and corn, remote sensing plays a substantial role in delivering timely information on the crop area for economic, environmental and policy studies.Traditional long-term mapping of soybean and corn is challenging as a result of the high cost of repeated... |
Women are more likely to experience repeated and extensive interpersonal violence in comparison to men.Experiencing IPV is strongly correlated with mental health problems such as post-traumatic stress disorder, depression, suicidal behaviours, as well as problematic substance use.Moreover, women using substances experi... | Background and aims: Women with histories of interpersonal violence (IPV) experience high levels of post-traumatic stress disorder (PTSD), problematic substance use, and repeat victimization.It is unclear what treatment components and contextual factors impacting implementation work best for women with IPV experiences.... |
of sessions forming many present-focused interventions also provides a template for longer term support in treatment services.The development of coping skills over time may help participants tolerate past-focused interventions to support memory processing should they need it.Greater relief is gained from PTSD symptoms ... | Previous systematic reviews considering the effectiveness of integrated trauma-specific treatments to address PTSD and substance use have lacked sub-group analysis by gender or trauma type.This narrative review examines a range of quantitative and qualitative data to explore: for which groups of women do integrated int... |
was run in duplicate, and the various compounds tested were compared to these values.In the FlashPlate® Scintillation Proximity Assay wells of a 96-well plate are coated with scintillant and capture antibody for tagged proteins.This requires just 100 ng of RAR proteins and 2 nM -retinoic acid per well.This enables comp... | A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5, which has good selectivity over the RARβ and RARγ receptors.Analysis of the medicinal chemist... |
higher that 1408 K.Additional results provided by the X-ray photoelectron spectroscopy analysis show the presence of SiOxCy bonds.The SiOxCy phase was mainly present during the first reaction stage.XPS profiles indicated a build-up of silicon oxide and unreacted carbon as the temperature increases due to the dissociati... | Abstract In this work the palladium interaction with silicon carbide is investigated by means of complementary analytical techniques such as thermogravimetry (TG), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).Thermoscans were carried out on pellets of palla... |
Previous work examining witness skills in autistic children has focused on the volume and accuracy of their recall for a witnessed event.No previous studies have examined whether these accounts are organised logically for the listener in terms of key ‘story grammar’ elements: information about the setting and the initi... | Background and Aims: Autistic children often recall fewer details about witnessed events than typically developing children (of comparable age and ability), although the information they recall is generally no less accurate.Previous research has not examined the narrative coherence of such accounts, despite higher qual... |
crime, witnessed earlier that day.Despite this difference in volume of correct recall, no significant group differences emerged when a ‘story grammar’ framework was used to assess the presence and number of key story elements in participants’ accounts.The findings confirm the utility of previous work using the story gr... | This study compared the narrative coherence of witness transcripts produced by autistic and typically developing (TD) children (ages 6–11 years, IQs 70+).Groups were matched on chronological age, IQ and receptive language ability.Coding frameworks were adopted from existing narrative research, featuring elements of ‘st... |
There are contrasting challenges in using agricultural environments: the imperative for intensifying food production for the growing human population, on one hand, and the need for protecting biodiversity and ecosystem services within them, on the other hand.In the pressure of these conflicting interests, many farmland... | The amount of High Nature Value farmland (HNVf) is a commonly used environmental indicator for assessing the performance of the Common Agricultural Policy, to support sustainable agriculture and monitor changes in agricultural land use in Europe.For a successful implementation, the identification of HNVf should correct... |
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