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|---|---|---|---|---|---|---|---|---|---|
5139f6311ca615e412ba97e9add02c38 | mteb/scifact | Mitochondria play a major role in energy production. | Mitochondria: Dynamic Organelles in Disease, Aging, and Development. Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-established functions, it might be expected that mitochondria... | [
"Transcriptional integration of mitochondrial biogenesis.. Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial biogenesis and function. Some of these factors act exclusively within the mitochondria to regulate the control of mitochondrial transcription, translation, and other funct... | 797 | 8551160 | [
"27693891",
"14972169",
"25251625",
"1360607"
] | scientific_claim_retrieval | scientific |
f441823c6f3d87f9cdeb2a68b493c22a | mteb/scifact | Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments. | Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We analy... | [
"Thresholds for the cost–effectiveness of interventions: alternative approaches. Many countries use the cost-effectiveness thresholds recommended by the World Health Organization's Choosing Interventions that are Cost-Effective project (WHO-CHOICE) when evaluating health interventions. This project sets the thresho... | 891 | 2097256 | [
"15670968",
"643765",
"29134911",
"42387637"
] | scientific_claim_retrieval | scientific |
1e1035e15fe60d9f67032e9272f386b0 | mteb/scifact | An M2-like phenotype in brown adipose tissue macrophages is quickly induced by cold exposure. | Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environments. In the prevailing model of thermogenesis, when the hypo... | [
"Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice. Brown adipocytes dissipate energy, whereas white adipocytes are an energy storage site. We explored the plasticity of different white adipose tissue depots in acquiring a brown phenotype by cold exposur... | 109 | 4319174 | [
"29381091",
"36838958",
"12658073",
"14865329"
] | scientific_claim_retrieval | scientific |
927d44b2a21673db3f1eb07d789e7448 | mteb/trec-covid | are cardiac complications likely in patients with COVID-19? | Acute respiratory distress syndrome and acute myocarditis developed in a previously healthy adult with influenza B. BACKGROUND: Influenza B virus infection is generally considered to be mild and is rarely associated pulmonary cardiovascular involvement in adults. However fatal complications may occur. CASE PRESENTATION... | [
"Demographic profile and outcome analysis of a tertiary level pediatric intensive care unit. Objective : To study the profile and outcome of children admitted to a tertiary level pediatric intensive care unit (PICU) in India.Methods : Prospective study of patient demographics, PRISM III scores, diagnoses, treatment... | 22 | ux6kt65o | [
"18dxcn41",
"zhw8vh3e",
"1ddfywfa",
"5yt1cgkx"
] | biomedical_literature_retrieval | scientific |
eb176465ecda5b899799c62c276a1976 | mteb/scifact | Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth. | Maximal aerobic capacity in African-American and Caucasian prepubertal children.. The purpose of this study was to examine differences in resting, submaximal, and maximal (VO2max) oxygen consumption (VO2) in African-American (n = 44) and Caucasian (n = 31) prepubertal children aged 5-10 yr. Resting VO2 was measured via... | [
"Comparison of Maximal Oxygen Consumption Between Black and White Prepubertal and Pubertal Children. The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between two selected groups of black and white children and whether a difference existed to determine whether i... | 945 | 26112696 | [
"18537148",
"11201004",
"24746892",
"8595678"
] | scientific_claim_retrieval | scientific |
c256ba702e877647252e3e7c0456f5e5 | mteb/scifact | L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex. | The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.. L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has not been defined. Here we show that disruption of L3mbtl2 re... | [
"Structure of Actin-related protein 8 and its contribution to nucleosome binding. Nuclear actin-related proteins (Arps) are subunits of several chromatin remodelers, but their molecular functions within these complexes are unclear. We report the crystal structure of the INO80 complex subunit Arp8 in its ATP-bound f... | 672 | 15635366 | [
"14155726",
"15600979",
"23244529",
"1635872"
] | scientific_claim_retrieval | scientific |
4bf9e808328dd489a788415ef3dc04e6 | mteb/scifact | Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in hepatic glucose metabolism. | Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis. During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated ... | [
"Regulation of Serum Amyloid A3 (SAA3) in Mouse Colonic Epithelium and Adipose Tissue by the Intestinal Microbiota. The gut microbiota has been proposed as an environmental factor that affects the development of metabolic and inflammatory diseases in mammals. Recent reports indicate that gut bacteria-derived lipopo... | 1045 | 22500262 | [
"12658073",
"13466622",
"14116046",
"13277039"
] | scientific_claim_retrieval | scientific |
44128a3a63dcde8ba2492f284fbf5eb7 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Essential epidemiological mechanisms underpinning the transmission dynamics of seasonal influenza. Seasonal influenza has considerable impact around the world, both economically and in mortality among risk groups, but there is considerable uncertainty as to the essential mechanisms and their parametrization. In this pa... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | wale2wiu | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
4796e5a40d1291089110a98838fca641 | mteb/scifact | Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden. | Accuracy of weighed dietary records in studies of diet and health.. OBJECTIVE To provide an independent evaluation of seven day weighed dietary records, which are currently accepted as the most accurate technique for assessing habitual dietary intake in studies investigating the links between diet and health. DESIGN Su... | [
"Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake.. CONTEXT Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal intake is not known. Serum 25-hydroxyvitamin D is the generally accepted indicator of v... | 1374 | 21993510 | [
"16256507",
"11837657",
"21676556",
"4346436"
] | scientific_claim_retrieval | scientific |
b8aba0465d2105e3e38b80fd018fe858 | mteb/scifact | MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß. | MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling. Nuclear factor-κB (NF-κB) is constitutively activated in diverse human malignancies by mechanisms that are not understood. The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas and, similarly to NF-κB, blocks apop... | [
"Parathyroid hormone induces E4bp4 messenger ribonucleic acid expression primarily through cyclic adenosine 3',5'-monophosphate signaling in osteoblasts.. PTH binding to its receptor activates protein kinase A (PKA), protein kinase C (PKC), and calcium signaling to induce transcription of primary response genes in ... | 740 | 23078022 | [
"21199527",
"6690087",
"28644298",
"6936141"
] | scientific_claim_retrieval | scientific |
7ae449a88c05a8621dad2fd83f7c6cb6 | mteb/scifact | Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments | Microenvironmental regulation of tumor progression and metastasis. Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive th... | [
"IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma. Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms invo... | 224 | 6944800 | [
"3376731",
"6807122",
"15832146",
"3727986"
] | scientific_claim_retrieval | scientific |
9ca1c97663f218dff90960df00b62a00 | mteb/scifact | Women with a lower birth weight are more likely to develop breast cancer later in life. | Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence.. BACKGROUND Emerging evidence suggests an association between female prenatal experience and her subsequent risk of developing breast cancer. Potential underlying mechanisms include variation in amounts of materna... | [
"Life course breast cancer risk factors and adult breast density (United Kingdom). Objective To determine whether risk factors in childhood and early adulthood affect later mammographic breast density. Methods: Subjects were 628 women who attended a medical examination at the University of Glasgow Student Health Se... | 1380 | 23557241 | [
"38784540",
"6327940",
"6748318",
"5487448"
] | scientific_claim_retrieval | scientific |
7b857a161bf2e4299c2ab1e765195eaf | mteb/scifact | Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years. | Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergic dis... | [
"Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review.. There are two main families of polyunsaturated fatty acids (PUFAs), the n-6 and the n-3 families. It has been suggested that there is a causal relationship between n-6 PUFA ... | 705 | 22442133 | [
"24269361",
"12009265",
"24346598",
"23342845"
] | scientific_claim_retrieval | scientific |
9f9951619a04c6d570717ae742c359d2 | mteb/scifact | Risedronate increases risk of vertebral and non-vertebral fractures. | Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group.. CONTEXT Risedronate, a potent bisphosphonate, has been shown to be effective in the treatment of Paget disea... | [
"Systematic review of role of bisphosphonates on skeletal morbidity in metastatic cancer.. OBJECTIVE To review the evidence for the use of bisphosphonates to reduce skeletal morbidity in cancer patients with bone metastases. DATA SOURCES Electronic databases, scanning reference lists, and consultation with experts ... | 1050 | 19878070 | [
"17482507",
"16812091",
"14021596",
"30292811"
] | scientific_claim_retrieval | scientific |
f0e039028e61c197f89ff7900233acd7 | mteb/trec-covid | which SARS-CoV-2 proteins-human proteins interactions indicate potential for drug targets. Are there approved drugs that can be repurposed based on this information? | BARICITINIB - A JANUASE KINASE INHIBITOR - NOT AN IDEAL OPTION FOR MANAGEMENT OF COVID 19. • Several studies suggested Baricitinib as a potential drug for the management of COVID 19 infection through drug repurposing strategies because of its ability to act on AT2 cells and AAK1 mediated endocytosis. • Baricitinib, a J... | [
"Single-Particle cryo-EM as a Pipeline for Obtaining Atomic Resolution Structures of Druggable Targets in Preclinical Structure-Based Drug Design. Single-particle cryo-electron microscopy (cryo-EM) and three-dimensional (3D) image processing have gained importance in the last few years to obtain atomic structures o... | 29 | 270msv5l | [
"6m06yzp7",
"njlqgih3",
"mw7athol",
"f089bs8r"
] | biomedical_literature_retrieval | scientific |
db184a29a32789e6f58d67569ca4015d | mteb/scifact | Misunderstandings between doctors and patients can lead to non-adherence. | Misunderstandings in prescribing decisions in general practice: qualitative study.. OBJECTIVES To identify and describe misunderstandings between patients and doctors associated with prescribing decisions in general practice. DESIGN Qualitative study. SETTING 20 general practices in the West Midlands and south east Eng... | [
"Interaction between broad-spectrum antibiotics and the combined oral contraceptive pill. A literature review.. There is considerable variation in opinion about the importance of drug interactions between the combined oral contraceptive pill (COCP) and broad-spectrum antibiotics. Clinical practice varies widely, es... | 792 | 3610080 | [
"35186640",
"21884449",
"22123421",
"9274291"
] | scientific_claim_retrieval | scientific |
622656ed0c8efcd29ddfcd45568b4630 | mteb/scifact | Acute ablation of Snail in the embryonic cortex affects the proliferation and number of embryonic cortical precursors. | Control of Apoptosis by Asymmetric Cell Division. Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally li... | [
"Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development.. The Snail transcription factor plays a key role in regulating diverse developmental processes but is not thought to play a role in mammalian neural precursors. Here, we have examined radial glia... | 81 | 1797622 | [
"38919140",
"18038250",
"33796570",
"9076196"
] | scientific_claim_retrieval | scientific |
6683b73d021656f51b471fc00895558f | mteb/scifact | The DESMOND program demonstrates no significant impact on lifestyles outcomes. | Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care. OBJECTIVE To measure whether the benefits of a single education and self management structured programme ... | [
"Transtheoretical model-based multiple behavior intervention for weight management: effectiveness on a population basis.. BACKGROUND The increasing prevalence of overweight and obesity underscores the need for evidence-based, easily disseminable interventions for weight management that can be delivered on a populat... | 1158 | 12584053 | [
"6841927",
"39264456",
"5641851",
"80522346"
] | scientific_claim_retrieval | scientific |
8b91f421de640826c5008aedc3660400 | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | SARS-CoV: Lessons for global health | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | e1sfuv1n | [
"xe0xey1n",
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"rjyu8lfl",
"acidfmjc"
] | biomedical_literature_retrieval | scientific |
d7c4f32dbfd32216d9be254cbe5f08a6 | mteb/trec-covid | how long can the coronavirus live outside the body | Global outbreak of severe acute respiratory syndrome (SARS) | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | 4xx548gs | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
6d04a96060f808d34378402d049edf27 | mteb/scifact | Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year. | Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergic dis... | [
"Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review.. There are two main families of polyunsaturated fatty acids (PUFAs), the n-6 and the n-3 families. It has been suggested that there is a causal relationship between n-6 PUFA ... | 709 | 22442133 | [
"24269361",
"23665162",
"10692948",
"791050"
] | scientific_claim_retrieval | scientific |
44a8211bd9a3e498fa18fd7e9350c633 | mteb/scifact | Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates. | The DNA Methylome of Human Peripheral Blood Mononuclear Cells. DNA methylation plays an important role in biological processes in human health and disease. Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried out on human cells. Using whole-genome bisulfite sequen... | [
"Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers.. Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused by mutations in the presenilin (PSEN) gene have been postulat... | 617 | 18670 | [
"8892905",
"8352137",
"6670101",
"14700857"
] | scientific_claim_retrieval | scientific |
211a5297cd886387d76ba8148e39cfc5 | mteb/scifact | Transcription rates in S. cerevisiae range between 0.7 and 2 kb/min. | Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.. A number of proteins and drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, but the factors that govern the elongation rate (nucleotide additions per min) and processivit... | [
"Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality. Importance Although non–vitamin K antagonist oral anticoagulants (NOACs) are increasingly used to prevent thromboembolic disease, there are limited data on ... | 1314 | 13072112 | [
"3898784",
"18537148",
"1495563",
"42441846"
] | scientific_claim_retrieval | scientific |
d51f9647a0eb31b7ed6a7f83272189cb | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Coronaviruses and Neuroantigens: myelin proteins, myelin genes. Multiple sclerosis (MS) is an autoimmune disease in which autoreactive T cells specific to central nervous system (CNS) myelin antigens are activated. Although disease etiology remains unknown, coronaviruses are suspected to be involved in MS pathology. Mo... | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | fwjjgvzy | [
"9807pgmy",
"1kwb0v71",
"5zuij5i3",
"xmjzgqq7"
] | biomedical_literature_retrieval | scientific |
1fb0ad066e5a777775804ac103b7178c | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Adult-Onset Still’s Disease. Adult-onset Still’s disease (AOSD) is a rare systemic, autoinflammatory disorder that often presents in adolescence and early adulthood with fever, rash, and polyarthritis. There are significant genetic and clinical similarities with systemic juvenile idiopathic arthritis (sJIA) with a diff... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | lvb79oxo | [
"32zroj99",
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"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
3cd510ef9793453b235e0cd06e88ff9e | mteb/scifact | Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells. | TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Leprosy enables investigation of mechanisms by which the innate immune system contributes to host defense against infection, because in one form, the disease progresses, and in the other, the infection is limited. We re... | [
"Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria.. Myeloid differentiation factor-2 (MD-2) is a lipopolysaccharide (LPS)-binding protein usually coexpressed with and binding to Toll-like receptor 4 (TLR4), conferring LPS responsiveness of immune cells. MD-2 is also found as a solubl... | 244 | 21498497 | [
"28517384",
"25050969",
"42465769",
"25606339"
] | scientific_claim_retrieval | scientific |
b2bf6201e55c476ff1b030ec89619de2 | mteb/scifact | Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period. | Reproductive period and risk of dementia in postmenopausal women.. CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied. OBJECTIVE To determine whether a longer rep... | [
"Cardiovascular risk factors and migraine: the GEM population-based study.. BACKGROUND Migraine, particularly with aura, is a risk factor for early-onset ischemic stroke. The underlying mechanisms are unknown, but may in part be due to migraineurs having an increased risk profile for cardiovascular disease. In this... | 416 | 6309659 | [
"23785605",
"6540064",
"27408104",
"57762078"
] | scientific_claim_retrieval | scientific |
39f9110651386fdcb5c17138a9aa8dbb | mteb/scifact | Sweet taste receptors on the tongue are deactivated by between 1 and 10 mM glucose. | Detection of sweet and umami taste in the absence of taste receptor T1r3.. The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells. Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as... | [
"Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.. Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion i... | 1118 | 23351136 | [
"20829129",
"13469921",
"3898784",
"24273592"
] | scientific_claim_retrieval | scientific |
b9111215158d6f5aaaba1b8153c595b2 | mteb/scifact | Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels. | Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts... | [
"LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys. Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that represents a promising target for the treatment of several metabolic diseases. Administration of recombinant wild type FGF21 to diabetic animals leads t... | 420 | 9315213 | [
"1840993",
"23397658",
"22401720",
"6227220"
] | scientific_claim_retrieval | scientific |
ef1da1d7d3b477677967313201caa6ff | mteb/scifact | The PRR MDA5 has a C-terminal domain. | Immune signaling by RIG-I-like receptors.. The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect viral RNA ligands or processed self RNA in the cytoplasm to trigger innate immunity and inflammation ... | [
"Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides.. Cathelicidins are a novel family of antimicrobial peptide precursors from mammalian myeloid cells. They are characterized by a conserved N-terminal region while the C-terminal antimicrobial domain can vary ... | 1178 | 31272411 | [
"22191759",
"42314147",
"33920995",
"20132778"
] | scientific_claim_retrieval | scientific |
620edf4c040633038a0a1e565ab62829 | mteb/scifact | MICAL redox enzymes regulate actin dynamics. | Drosophila MICAL regulates myofilament organization and synaptic structure. The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abnormally structured neuromuscular junctions (NMJs), we discov... | [
"Mical links semaphorins to F-actin disassembly. How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studied for their effects on cell movement, navigation, an... | 738 | 16562534 | [
"4417558",
"3506723",
"6784372",
"36345185"
] | scientific_claim_retrieval | scientific |
533098df7f7460f97eb073e33d3595ca | mteb/scifact | In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions. | Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae.. Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracellular iron toxicity. We show that many mRNAs encoding iron u... | [
"Pseudo-Seq: Genome-Wide Detection of Pseudouridine Modifications in RNA.. RNA molecules contain a variety of chemically diverse, posttranscriptionally modified bases. The most abundant modified base found in cellular RNAs, pseudouridine (Ψ), has recently been mapped to hundreds of sites in mRNAs, many of which are... | 565 | 16120395 | [
"2721426",
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] | scientific_claim_retrieval | scientific |
d1994772871f191bb31d590ae6d0b810 | mteb/trec-covid | what are the transmission routes of coronavirus? | Animals and Mechanisms of Disease Transmission. More than 60% of human infectious diseases are shared with domestic or wild animals, with over a billion illnesses in the global population and millions of deaths each year. It is estimated that 75% of emerging infectious diseases are zoonoses. There is a great diversity ... | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | 0nhfqzjg | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
3b890ca0019c23e243aac5cb61dca291 | mteb/trec-covid | what are the guidelines for triaging patients infected with coronavirus? | Introduction and Executive Summary: Care of the Critically Ill and Injured During Pandemics and Disasters: CHEST Consensus Statement. Natural disasters, industrial accidents, terrorism attacks, and pandemics all have the capacity to result in large numbers of critically ill or injured patients. This supplement provides... | [
"2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients. BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung disease... | 11 | ul91jrpd | [
"jzlouns7",
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84a9621f7449277f463e9499b53fafdb | mteb/scifact | Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system. | AgDscam, a Hypervariable Immunoglobulin Domain-Containing Receptor of the Anopheles gambiae Innate Immune System. Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interacting with pathogen-associated molecular pattern. Here we report a nov... | [
"Current knowledge and future directions of TLR and NOD signaling in sepsis. The incidence of sepsis is increasing over time, along with an increased risk of dying from the condition. Sepsis care costs billions annually in the United States. Death from sepsis is understood to be a complex process, driven by a lack ... | 356 | 6144337 | [
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"40323148"
] | scientific_claim_retrieval | scientific |
9825555a04b5e06301b85eae2c8fef45 | mteb/scifact | Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs). | Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.. CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs. However, whether pharmacist participation in the ICU at ... | [
"A literature review of the safety of medical body area network devices in magnetic resonance imaging. Electro-magnetic fields and wireless technology are part of modern life. The use of Magnetic Resonance Imaging (MRI) machines for clarification of internal human structures and function in healthcare is increasing... | 601 | 12258338 | [
"11884867",
"5402581",
"437924",
"5855168"
] | scientific_claim_retrieval | scientific |
bdb00ef1b9d30c1d6b5a40485eb6f268 | mteb/scifact | Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake. | The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis.. OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate conce... | [
"Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia. BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygou... | 253 | 37424881 | [
"18174210",
"32328114",
"8595678",
"18190552"
] | scientific_claim_retrieval | scientific |
02514f0c8563936ddf9ca620964e1d78 | mteb/trec-covid | how long can the coronavirus live outside the body | Viruses Present Indoors and Analyses Approaches. Through human history viruses have shown enormous epidemiological and pandemic potential as the occurrence and spread of viruses in pandemic dimensions poses a threat to the health and lives of seven billion people worldwide. Scientific evidence has associated harmful he... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | c9ts2g7w | [
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"mw7athol"
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131330046192b08fa2f57696e3b2e3d0 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Airborne Precautions and Personal Protective Equipment: The Powered Air-Purifying Respirator-Only Approach. Airborne isolation of patients and use of respirators are a foundational strategy to prevent transmission of pathogens like tuberculosis and novel respiratory viruses via airborne route in healthcare settings. He... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | 3sdmqj4e | [
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e88459ccaae57f98eda6a35bfb1568ad | mteb/scifact | Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis. | Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma. Although GBP1 (guanylate binding protein 1) was among the first interferon-inducible proteins identified, its function is still largely unknown. Epidermal growth factor receptor (EGFR) activation by amplification or mutation is one... | [
"Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis.. Epidermal growth factor receptor (EGFR) is a known diagnostic and, although controversial, prognostic marker of human glioblastoma... | 470 | 12685434 | [
"7028976",
"13235609",
"22901758",
"1285713"
] | scientific_claim_retrieval | scientific |
7cc0ae7eff217f6b3eca9705c46e042f | mteb/scifact | Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice. | Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development. BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumula... | [
"Exploring and exploiting the systemic effects of deregulated replication licensing.. Maintenance and accurate propagation of the genetic material are key features for physiological development and wellbeing. The replication licensing machinery is crucial for replication precision as it ensures that replication tak... | 335 | 1780819 | [
"4767806",
"8133180",
"8774475",
"8764879"
] | scientific_claim_retrieval | scientific |
933a0a45492142accf64922ce99932a6 | mteb/scifact | Oxidative DNA damage activates STING signalling. | Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.. The role of ataxia telangiectasia mutated (ATM), a DNA double-strand break recognition and response protein, in inflammation and inflammatory diseases is unc... | [
"Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage.. Many studies have shown that caloric restriction (40%) decreases mitochondrial reactive oxygen species (ROS) generation in rodents. Moreover, we have recently found that 7 weeks of 40% protein restriction without strong... | 898 | 5572127 | [
"44693226",
"13023410",
"21295300",
"1635872"
] | scientific_claim_retrieval | scientific |
08cc525ac776b1b585b36b02768659bf | mteb/scifact | Natriuretic peptides increase susceptibility to diabetes. | Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies. BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but the pro... | [
"Plasma Corin as a Predictor of Cardiovascular Events in Patients With Chronic Heart Failure.. OBJECTIVES The aim of this study was to determine the prognostic value of plasma corin in patients with chronic heart failure (CHF). BACKGROUND In recent years, accumulating evidence has indicated that corin plays a criti... | 840 | 15663829 | [
"4445629",
"34054472",
"5567005",
"8839502"
] | scientific_claim_retrieval | scientific |
49add095698427b13195380781538fce | mteb/scifact | Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients. | A framework for understanding and targeting residual disease in oncogene-driven solid cancers. Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers. Eve... | [
"Subsequent chemotherapy reverses acquired tyrosine kinase inhibitor resistance and restores response to tyrosine kinase inhibitor in advanced non-small-cell lung cancer. BACKGROUND Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can develop acquired resistance to epidermal growth factor rec... | 939 | 26231129 | [
"9929089",
"30658796",
"2272614",
"17876040"
] | scientific_claim_retrieval | scientific |
b7dc984b224a27893a84148721504e48 | mteb/scifact | Oxidative DNA damage inhibits STING signalling. | Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.. Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a ... | [
"A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion.. Cigarette smoke and smokeless tobacco extracts contain multiple carcinogenic compounds, but little is known about the mechanisms by which tumors develop and progress upon chronic exposure to carcinogens such as... | 899 | 13106686 | [
"1192458",
"13023410",
"4444861",
"1635872"
] | scientific_claim_retrieval | scientific |
4978c4a5d018a86670f8470a01589668 | mteb/scifact | Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose. | Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study.. CONTEXT The mechanisms that drive progression from fatty liver to steatohepatitis and cirrhosis are unknown. In animal models, obese mice with fatty livers are vulnerable to liver adenosine triphosphate (ATP) depletion and necro... | [
"T1 mapping for myocardial extracellular volume measurement by CMR: bolus only versus primed infusion technique.. OBJECTIVES The aim of this study was to determine the accuracy of the contrast \"bolus only\" T1 mapping cardiac magnetic resonance (CMR) technique for measuring myocardial extracellular volume fraction... | 504 | 10883736 | [
"27550580",
"4999633",
"29689140",
"30553457"
] | scientific_claim_retrieval | scientific |
8599b4bf43b75f1dda1c073a414779df | mteb/scifact | Tonic signaling from the scFv induces constitutive stimulation. | 4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors. Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains un... | [
"Angiotensin II Evokes Angiogenic Signals within Skeletal Muscle through Co-ordinated Effects on Skeletal Myocytes and Endothelial Cells. Skeletal muscle overload induces the expression of angiogenic factors such as vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-2, leading to new capil... | 1307 | 18231807 | [
"17546486",
"8246922",
"5914739",
"20829129"
] | scientific_claim_retrieval | scientific |
027a369fbf807eaa95fe0f025218e777 | mteb/scifact | Taxation of sugar-sweetened beverages reduced the incidence rate of type II diabetes in India. | Averting Obesity and Type 2 Diabetes in India through Sugar-Sweetened Beverage Taxation: An Economic-Epidemiologic Modeling Study. BACKGROUND Taxing sugar-sweetened beverages (SSBs) has been proposed in high-income countries to reduce obesity and type 2 diabetes. We sought to estimate the potential health effects of su... | [
"Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women.. CONTEXT Sugar-sweetened beverages like soft drinks and fruit punches contain large amounts of readily absorbable sugars and may contribute to weight gain and an increased risk of type 2 diabetes, but these rel... | 1145 | 10071552 | [
"9822397",
"25643818",
"30805636",
"3770750"
] | scientific_claim_retrieval | scientific |
8d0adae42e79fc6dcfb9e1159a683bc7 | mteb/scifact | Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery. | Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.. CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. OBJECTIVE To determine if surgically induced weight loss results in better glycemic control ... | [
"Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in ... | 341 | 7098463 | [
"5824985",
"750781",
"32850528",
"25816994"
] | scientific_claim_retrieval | scientific |
30a0fc0eb3d93aeb0716bbd7ad52db4f | mteb/trec-covid | how does the coronavirus respond to changes in the weather | Estimated Effects of Projected Climate Change on the Basic Reproductive Number of the Lyme Disease Vector Ixodes scapularis. Background: The extent to which climate change may affect human health by increasing risk from vector-borne diseases has been under considerable debate. Objectives: We quantified potential effect... | [
"Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression. The mitochondrial protein repertoire varies depending on the cellular state. Protein component modifications caused by mitochondrial DNA (mtDNA) depletion are related to a wide range of human diseases; however, little is know... | 2 | 6hwedoh7 | [
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2f997e9ef2b108ee6fc44b14ac934574 | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Metalloproteases and Proteolytic Processing. Proteolytic enzymes constitute around 2% of the human genome and are involved in all stages of cell and organism development from fertilization through to cell death. In the human genome the major classes of peptidases are represented by cysteine-, serine- and metalloenzymes... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | vbu1le29 | [
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"xzb0sw2z"
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5c49e2f00cd3721ad5e086af669fa1db | mteb/trec-covid | what are the guidelines for triaging patients infected with coronavirus? | COVID-19 in Italy: Ageism and Decision-Making in a Pandemic | [
"2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients. BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung disease... | 11 | vahd59z8 | [
"jzlouns7",
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c628c540d122ec013f05cf7fcbbf31bd | mteb/scifact | Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage. | Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis. Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation, apoptosis and cellular transitions. Here we show that the ... | [
"Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.. Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in ... | 670 | 5573975 | [
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84f7858df0b5907a1dfad01d96b5575c | mteb/scifact | Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids. | Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, which neutrali... | [
"Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage. Broadly neutralizing antibodies (bnAbs) to HIV-1 can evolve after years of an iterative process of virus escape and antibody adaptation that HIV-1 vaccine design seeks to mimic. To e... | 189 | 4421578 | [
"3566945",
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"8883846",
"13469921"
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fb015a53db08be38ba2c9d911264ab86 | mteb/trec-covid | which SARS-CoV-2 proteins-human proteins interactions indicate potential for drug targets. Are there approved drugs that can be repurposed based on this information? | Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China. A novel coronavirus (2019-nCoV) originating in Wuhan, China presents a potential respiratory viral pandemic to the world population. Current efforts are focused on containment and quarantine of infected individual... | [
"Single-Particle cryo-EM as a Pipeline for Obtaining Atomic Resolution Structures of Druggable Targets in Preclinical Structure-Based Drug Design. Single-particle cryo-electron microscopy (cryo-EM) and three-dimensional (3D) image processing have gained importance in the last few years to obtain atomic structures o... | 29 | 2jq626ye | [
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9437fa10bc1cb4a48b3ab98d0f92034b | mteb/scifact | Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes. | Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with different... | [
"Key role for IL-21 in experimental autoimmune uveitis.. IL-21 is a pleiotropic type 1 cytokine that shares the common cytokine receptor γ-chain, γ(c), with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is most homologous to IL-2. These cytokines are encoded by adjacent genes, but they are functionally distinct. Whereas... | 1028 | 13923140 | [
"7115651",
"36642096",
"5476778",
"26068103"
] | scientific_claim_retrieval | scientific |
1b31322a52fb2e0a3c2e7fd87c3c2fa2 | mteb/trec-covid | what is the origin of COVID-19 | The Origin and Evolution of Viruses. The lecture covers three main topics: (i) Viruses: properties, place in the living world, and possible origin; (ii) Molecular basis of viral variability and evolution; and (iii) Evolution of viral pathogenicity and emerging viral infections | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | gy8d8285 | [
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"35c6mak0",
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4b9eeac28dc2cf72bb26cf7b738166af | mteb/scifact | Activator-inhibitor pairs are provided ventrally by Xrl-sizzled. | Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field. Embryos have the ability to self-regulate and regenerate normal structures after being sectioned in half. How is such a morphogenetic field established? We discovered that quadruple knockdown of ADMP and BMP2/4/... | [
"The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4.. Cells can respond to mechanical stress by gating mechanosensitive ion channels (MSCs). The cloning of Piezo1, a eukaryotic cation selective MSC, defines a new system for studying mechanical transduction at the cellular level. Because Piez... | 73 | 6076903 | [
"26047921",
"4587978",
"18447487",
"23513718"
] | scientific_claim_retrieval | scientific |
7dee90de03c73320a4c69d808b4fbfc6 | mteb/scifact | Side effects associated with antidepressants do not represent a mortality risk to postmenopausal women. | Antidepressant use and risk of adverse outcomes in older people: population based cohort study. OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and ... | [
"Self-harm in prisons in England and Wales: an epidemiological study of prevalence, risk factors, clustering, and subsequent suicide. BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of people at risk of self-harm is scant. Furthermore, understa... | 1081 | 5691302 | [
"13900610",
"11939159",
"5698494",
"583260"
] | scientific_claim_retrieval | scientific |
0f9ad86f1fca1b4f4a6516a2d3cb00f1 | mteb/scifact | Foxk2 regulates autophagy genes in muscle cells and fibroblast cells. | Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. Autophagy is the primary catabolic process triggered in response to starvation. Although autophagic regulation within the cytosolic compartment is well established, it is becoming clear that nuclear events also regulate the induc... | [
"MicroRNA-21 is Induced by Rapamycin in a Model of Tuberous Sclerosis (TSC) and Lymphangioleiomyomatosis (LAM). Lymphangioleiomyomatosis (LAM), a multisystem disease of women, is manifest by the proliferation of smooth muscle-like cells in the lung resulting in cystic lung destruction. Women with LAM can also devel... | 432 | 8002887 | [
"2266471",
"4460880",
"30933307",
"15635366"
] | scientific_claim_retrieval | scientific |
eeb8356369989e0531505bf9b00dedea | mteb/scifact | miR-142-5P is a temperature-sensitive microRNA (miRNA). | RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever. Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly un... | [
"A microRNA feedback loop regulates global microRNA abundance during aging.. Expression levels of many microRNAs (miRNAs) change during aging, notably declining globally in a number of organisms and tissues across taxa. However, little is known about the mechanisms or the biological relevance for this change. We in... | 1392 | 6766459 | [
"9159495",
"8247469",
"23126677",
"8702697"
] | scientific_claim_retrieval | scientific |
8a69bdab59ba4b7b1a4c6425f3991c85 | mteb/scifact | Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae. | Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.. Calorie restriction extends life-span in a wide variety of organisms. Although it has been suggested that calorie restriction may work by reducing the levels of reactive oxygen species produced during respiration, t... | [
"Yeast sirtuins and the regulation of aging.. The sirtuins are a phylogenetically conserved family of NAD(+) -dependent protein deacetylases that consume one molecule of NAD(+) for every deacetylated lysine side chain. Their requirement for NAD(+) potentially makes them prone to regulation by fluctuations in NAD(+)... | 472 | 26330861 | [
"1754001",
"4463811",
"9310407",
"323335"
] | scientific_claim_retrieval | scientific |
b1b721400712e747aa6fe2dae8f085b5 | mteb/scifact | Monoclonal antibody targeting of N-cadherin inhibits growth. | Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CRPC xe... | [
"VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.. Inhibition of VEGF signaling leads to a proinvasive phenotype in mouse models of glioblastoma multiforme (GBM) and in a subset of GBM patients treated with bevacizumab. Here, we demonstrate that vascular endothelial growth ... | 804 | 22180793 | [
"13235609",
"25543207",
"6550579",
"12622860"
] | scientific_claim_retrieval | scientific |
4d950a8ffb4fa30dfa3b3f4d836d3a66 | mteb/scifact | DUSP4 decreases apoptosis. | Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which c... | [
"tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1. Recent studies suggest a close relationship between cell metabolism and apoptosis. We have evaluated changes in lipid metabolism on permeabilized hepatocytes treated with t... | 306 | 7821634 | [
"35962023",
"33370",
"29231620",
"40127292"
] | scientific_claim_retrieval | scientific |
76ecd76accd62ca2869597eb3aab3a1a | mteb/scifact | Egr3 regulates the homeostasis of B and T cells. | The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells. Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However, the intrinsic mechanisms regulating these responses are unknown. Here, we report... | [
"Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune path... | 371 | 1550937 | [
"7399084",
"32101982",
"14767844",
"25453683"
] | scientific_claim_retrieval | scientific |
bf0b9d57eb5df5c297c54a62150c7f9a | mteb/scifact | The PRDM1 gene is a key determinant of primordial germ cells. | The Germ Cell Determinant Blimp1 Is Not Required for Derivation of Pluripotent Stem Cells. Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells. They together initiate epigenetic reprogramming in early g... | [
"ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a.. ATP-dependent chromatin remodeling complexes are a notable group of epigenetic modifiers that use the energy of ATP hydrolysis to change the structure of chromatin, thereby altering its accessibility to nucle... | 1176 | 13910150 | [
"26612216",
"22150633",
"27569370",
"11335860"
] | scientific_claim_retrieval | scientific |
c2f0c39d45e5db644d59f65cf0519a32 | mteb/scifact | Allogeneic mechanical circulatory support is not as effective as autologous mechanical circulatory support for treating acute myocardial infarction. | Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial.. CONTEXT Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). Both autologous a... | [
"Coronary plaque disruption.. Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and plaque disruption with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina, myocardial infarction, and sudden death.1 2 3 4 5 Therefore, for event-free sur... | 104 | 40164383 | [
"19332616",
"9460704",
"11344428",
"83667891"
] | scientific_claim_retrieval | scientific |
d4b92f9ea2e0d516dddf0a1d1dfbba62 | mteb/scifact | The TRaF1/C5 rs10818488 allele polymorphism regulates the neighboring C5 gene. | A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis. Correction for: Kurreeman FAS, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, et al. (2007) A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis. PLoS Med 4(9): e278. do... | [
"Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta. The transmembrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that regulates innate immunity but has no known functions in the brain. We have previously shown that the CD33 gene is a risk factor for Alzheimer's dise... | 1183 | 1967017 | [
"7221410",
"13906892",
"140874",
"263364"
] | scientific_claim_retrieval | scientific |
8f33185b6f4016f9f1283e255c4d6dcd | mteb/scifact | Ten percent (10%) of kidney cancers in the UK are attributable to excess weight. | Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults. BACKGROUND High body-mass index (BMI) predisposes to several site-specific cancers, but a large-scale systematic and detailed characterisation of patterns of risk across all common cancers adjusted for potential ... | [
"Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries.. OBJECTIVES To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental, occupational, and ... | 1148 | 4828631 | [
"14700857",
"40949706",
"19205326",
"18816720"
] | scientific_claim_retrieval | scientific |
8196b47f5caabf83572ad5531dca5a5b | mteb/scifact | Transcription factor EB induces transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus. | Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.. Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation of the transcription factor... | [
"Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication.. TLR3 has been implicated in the pathogenesis of several viral infections, including SIV- and HIV-1-induced inflammation and AIDS. However the molecu... | 1312 | 24177706 | [
"25606339",
"1550937",
"343052",
"4418070"
] | scientific_claim_retrieval | scientific |
15634621dd6f128bb5ece446d1b1a58a | mteb/scifact | BiP is a general endoplasmic reticulum stress marker. | Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an importan... | [
"Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Increased lipid supply causes beta cell death, which may contribute to reduced beta cell mass in type 2 diabetes. We investigated whether endoplasmic reticulum (ER) stress is necessary for lipid-induced apoptosis in beta cells and ... | 176 | 32587939 | [
"25510546",
"20904154",
"4911006",
"20649327"
] | scientific_claim_retrieval | scientific |
302fe8e19462436fc8c86f6e2edb7633 | mteb/scifact | Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons. | Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector. Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using hum... | [
"Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. OBJECTIVE IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exercise by skeletal muscle and has been reported to redu... | 286 | 4709641 | [
"52865789",
"6776834",
"27602752",
"24652030"
] | scientific_claim_retrieval | scientific |
e06831aa669f406850d9893788498790 | mteb/scifact | FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS). | Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.. The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control... | [
"Glucose Metabolism Inhibits Apoptosis in Neurons and Cancer Cells by Redox Inactivation of Cytochrome c. Neurons and cancer cells use glucose extensively, yet the precise advantage of this adaptation remains unclear. These two seemingly disparate cell types also show an increased regulation of the apoptotic pathwa... | 430 | 28937856 | [
"23887844",
"14092737",
"2543135",
"9878167"
] | scientific_claim_retrieval | scientific |
5ed3927313d5b91f598f55cebeb2df3b | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Cyberbiosecurity Challenges of Pathogen Genome Databases. Pathogen detection, identification, and tracking is shifting from non-molecular methods, DNA fingerprinting methods, and single gene methods to methods relying on whole genomes. Viral Ebola and influenza genome data are being used for real-time tracking, while f... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | x6s34z1s | [
"6324190r",
"ukqvhzws",
"qyb8er14",
"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
d516765ff1eff598aa02d4c00c6be7f1 | mteb/scifact | Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology. | Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer.. More than ever, clinicians need regularly updated reviews given the continuously increasing amount of new information regarding innovative cervical cancer prevention methods. A summary is given from recent meta-analyses and sys... | [
"Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.. BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clin... | 973 | 28617573 | [
"6561200",
"19140422",
"16980892",
"76415938"
] | scientific_claim_retrieval | scientific |
4fa85900fcdf516d7e56acc2ae11751b | mteb/scifact | PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication. | PrimPol, an Archaic Primase/Polymerase Operating in Human Cells. We describe a second primase in human cells, PrimPol, which has the ability to start DNA chains with deoxynucleotides unlike regular primases, which use exclusively ribonucleotides. Moreover, PrimPol is also a DNA polymerase tailored to bypass the most co... | [
"The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.. Cells cope with blockage of replication fork progression in a manner that allows DNA synthesis to be completed and genomic instability minimized. Models for resolu... | 969 | 17368516 | [
"37328025",
"36606083",
"39225849",
"25787749"
] | scientific_claim_retrieval | scientific |
4d5b9ad7bc173cc4ae8634252c5bc714 | mteb/scifact | Gpr124 increases BBB breakdown in mouse models of ischemic stroke. | Gpr124 is essential for blood–brain barrier integrity in central nervous system disease. Although blood–brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined. The endothelial G-protein-coupl... | [
"Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I. Chromosome segregation during cell division depends on stable attachment of kinetochores to spindle microtubules. Mitotic spindle formation and kinetochore-microtubule (K-MT) capture typically occur within minutes of... | 479 | 6325527 | [
"6472746",
"18256197",
"3761017",
"368506"
] | scientific_claim_retrieval | scientific |
7fad46ac9810725758579037a379e111 | mteb/scifact | Energy balance requires hypothalamic glutamate neurotransmission. | Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.. The melanocortin receptor 4 (MC4R) is a well-established mediator of body weight homeostasis. However, the neurotransmitter(s) that mediate MC4R function remain largely unknown; as a result, little is known about the ... | [
"The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.. BACKGROUND Relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) afferents. Syste... | 378 | 45154987 | [
"4700428",
"16398827",
"2481032",
"14782049"
] | scientific_claim_retrieval | scientific |
b030c37244cc074f4adc960f2e2fde3e | mteb/trec-covid | what are the health outcomes for children who contract COVID-19? | Findings in children severely infected with a novel influenza A virus of swine origin: pulmonary imaging. BACKGROUND: This article reviews the chest radiography of children with severe infection caused by a novel influenza A (H1N1) virus of swine origin (S-OIV). We analyzed the role of their pulmonary images in predict... | [
"What is the diagnostic accuracy of single nerve conduction studies and muscle ultrasound to identify critical illness polyneuromyopathy: a prospective cohort study. BACKGROUND: Critical illness polyneuromyopathy (CIPNM) is a major cause of weakness in intensive care unit (ICU) patients, but current diagnostic test... | 47 | 2bnipi67 | [
"xtehuzt8",
"j7w5uee2",
"nkr9g0cu",
"qvevfimk"
] | biomedical_literature_retrieval | scientific |
d2503075e961ae3f6e066348e10e89f9 | mteb/scifact | Klf4 is important for proper myeloid cell differentiation. | Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo.. Several members of the Kruppel-like factor (KLF) family of transcription factors play important roles in differentiation, survival, and trafficking of blood and immune cell types. We demonstrate in this study that hematopoietic cells... | [
"Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling.. Chronic inflammation constitutes an important link between obesity and its pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a fundamentally negative impact on metabolism, we show that pro... | 668 | 25148216 | [
"5106691",
"15983148",
"21932050",
"23460562"
] | scientific_claim_retrieval | scientific |
a622e3abe980a33e5a77661fd8cc4b0d | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Functional analysis of the receptor binding domain of SARS coronavirus S1 region and its monoclonal antibody. Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (CoV). The spike protein of SARS-CoV consists of S1 and S2 domains, which are responsible for virus binding and fusion, respectively. T... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | lv8mll28 | [
"mx4t6s6n",
"r8fmq65g",
"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
e69cca169b76684c09cf308955a9faa2 | mteb/trec-covid | what are the transmission routes of coronavirus? | Noninvasive ventilation in acute respiratory failure due to H1N1 influenza: A word of caution | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | uvv06b4n | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
0306d57f1b97a53f1ab4b24faceead0d | mteb/scifact | Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum. | Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia. BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygous for... | [
"Parasite multiplication potential and the severity of Falciparum malaria.. The multiplication rates and invasiveness of Plasmodium falciparum parasites isolated from adult Thai patients hospitalized with uncomplicated malaria (n=34) were compared with those from persons with severe malaria (n=42). To simulate seve... | 929 | 18174210 | [
"40900567",
"17077004",
"25420421",
"9254550"
] | scientific_claim_retrieval | scientific |
6949aebb8e526711b21bf0acfc1b276d | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation. Influenza viruses present major challenges to public health, evident by the 2009 influenza pandemic. Highly pathogenic influenza virus infections generally coincide with early, high levels of inflammatory cytokines that some studies have sugges... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 68y733y3 | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
5edd0308b77e7a0f7aacb49f6d25f9ca | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | Understanding the Impact of Face Mask Usage Through Epidemic Simulation of Large Social Networks. Evidence from the 2003 SARS epidemic and 2009 H1N1 pandemic shows that face masks can be an effective non-pharmaceutical intervention in minimizing the spread of airborne viruses. Recent studies have shown that using face ... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | 14x4uqq7 | [
"beqvgdjo",
"y09mca1m",
"0quwwawp",
"rdnrbwkq"
] | biomedical_literature_retrieval | scientific |
166b064c1e511ef5296ba1ab9082ff40 | mteb/scifact | Immune complex triggered cell death leads to extracellular release of nuclear DNA. | Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune complexes (RNP ... | [
"A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus.. Neutrophil extracellular traps (NETs) are webs of DNA covered with antimicrobial molecules that constitute a newly described killing mechanism in innate immune defense. Previous publications reported t... | 555 | 1049501 | [
"43054703",
"9878167",
"20610557",
"6144969"
] | scientific_claim_retrieval | scientific |
c3b2a1b6c289fa8270610b54da55d9b9 | mteb/scifact | Women with a lower birth weight are more likely to develop breast cancer later in life. | Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies. BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent. We re-analysed individual participant d... | [
"Life course breast cancer risk factors and adult breast density (United Kingdom). Objective To determine whether risk factors in childhood and early adulthood affect later mammographic breast density. Methods: Subjects were 628 women who attended a medical examination at the University of Glasgow Student Health Se... | 1380 | 16322674 | [
"38784540",
"6327940",
"6748318",
"5487448"
] | scientific_claim_retrieval | scientific |
222a6abd900ace97fb15b1a7f4f18875 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Elevation of Intact and Proteolytic Fragments of Acute Phase Proteins Constitutes the Earliest Systemic Antiviral Response in HIV-1 Infection. The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or containment. During... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | sbxqwfmy | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
a1ee2395c8597faa2ce84fa4a4afb3c5 | mteb/scifact | Hypothalamic glutamate neurotransmission is unrelated to energy balance. | Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.. The melanocortin receptor 4 (MC4R) is a well-established mediator of body weight homeostasis. However, the neurotransmitter(s) that mediate MC4R function remain largely unknown; as a result, little is known about the ... | [
"In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus.. The cognitive deficits observed in children with cyanotic congenital heart disease suggest involvement of the developing hippocampus. Chronic postnatal hypoxia present during infancy in these children may play a role... | 541 | 45154987 | [
"14782049",
"4611267",
"4469125",
"46451940"
] | scientific_claim_retrieval | scientific |
0f38c6988470d1d10d9aa4997afb6a6b | mteb/scifact | AMP-activated protein kinase (AMPK) activation reduces inflammation-related fibrosis in the lungs. | Metformin reverses established lung fibrosis in a bleomycin model. Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs in a number of organs, including the lungs1. Cellular metabolism regulates tissue repair and remodelling responses to injury2-4. AMPK is a critical sensor o... | [
"Hypoxia-induced energy stress regulates mRNA translation and cell growth.. Oxygen (O2) deprivation, or hypoxia, has profound effects on cell metabolism and growth. Cells can adapt to low O2 in part through activation of hypoxia-inducible factor (HIF). We report here that hypoxia inhibits mRNA translation by suppre... | 55 | 49556906 | [
"14874811",
"24721866",
"9899292",
"22036571"
] | scientific_claim_retrieval | scientific |
03b5b5b3ea626e5a08fda2794e6705be | mteb/scifact | Side effects associated with antidepressants lower risk of myocardial infarction. | Antidepressant use and risk of adverse outcomes in older people: population based cohort study. OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and ... | [
"0021-972X/06/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 91(3):760–771 Printed in U.S.A. Copyright © 2006 by The Endocrine Society doi: 10.1210/jc.2005-1923 REVIEW: Aromatase Inhibitors for Ovulation Induction. CONTEXT For the last 40 yr, the first line of treatment for anovulation in infertile wom... | 1085 | 5691302 | [
"14827874",
"12770738",
"14803797",
"5824985"
] | scientific_claim_retrieval | scientific |
0862fd2e493f11760f173d8a897bc566 | mteb/scifact | The repeat-variable diresidue (RVD) in the loop of Transcription-Activator Like (TAL) effectors specifies the nucleotides-amino acid contact at the target promoter element. | Structural basis for sequence-specific recognition of DNA by TAL effectors.. TAL (transcription activator-like) effectors, secreted by phytopathogenic bacteria, recognize host DNA sequences through a central domain of tandem repeats. Each repeat comprises 33 to 35 conserved amino acids and targets a specific base pair ... | [
"The crystal structure of TAL effector PthXo1 bound to its DNA target.. DNA recognition by TAL effectors is mediated by tandem repeats, each 33 to 35 residues in length, that specify nucleotides via unique repeat-variable diresidues (RVDs). The crystal structure of PthXo1 bound to its DNA target was determined by h... | 1263 | 3981729 | [
"46816158",
"19099739",
"3893473",
"23985464"
] | scientific_claim_retrieval | scientific |
e8a3cdb3939d2a4eec19d817187323da | mteb/trec-covid | how does the coronavirus respond to changes in the weather | Seasonality of viral respiratory infections in southeast of Brazil: the influence of temperature and air humidity. Viruses are the major cause of lower respiratory tract infections in childhood and the main viruses involved are Human Respiratory Syncytial Virus (HRSV), Human Metapneumovirus (HMPV), Influenzavirus A and... | [
"Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression. The mitochondrial protein repertoire varies depending on the cellular state. Protein component modifications caused by mitochondrial DNA (mtDNA) depletion are related to a wide range of human diseases; however, little is know... | 2 | byant7dh | [
"9egy68c0",
"4cjlolp6",
"7o6htufh",
"upjhmfca"
] | biomedical_literature_retrieval | scientific |
536739169625297b00a64e84f5be5ed7 | mteb/scifact | N348I mutations reduce resistance to nevirapine. | N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance. Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almos... | [
"A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease. Autosomal dominant polycystic kidney disease (ADPKD) is caused by heterozygous mutations in either PKD1 or PKD2, genes that encode polycystin-1 and polycystin-2, respectively. We show here that tumor necrosis factor-... | 825 | 15319019 | [
"25089501",
"2481032",
"51706771",
"14819804"
] | scientific_claim_retrieval | scientific |
95cf6b1316f774a522ed61273d7bb75d | mteb/scifact | ART substantially reduces infectiveness of HIV-positive people. | HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa. BACKGROUND Many mathematical models have investigated the impact of expanding access to antiretroviral therapy (ART) on new HIV infections. Comparing results and ... | [
"Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model.. BACKGROUND Roughly 3 million people worldwide were receiving antiretroviral therapy (ART) at the end of 2007, but an estimated 6.7 million were still in need of treatment ... | 61 | 13899137 | [
"374902",
"46353045",
"31562330",
"17415081"
] | scientific_claim_retrieval | scientific |
d5b0d483122b7275b7734d88afbc7736 | mteb/scifact | Pioglitazone use is significantly associated with an increased risk of pancreatic cancer. | Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.. IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PARTICIP... | [
"The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis. OBJECTIVE To examine the safety of using aliskiren combined with agents used to block the renin-angiotensin system. DESIGN Systematic review... | 953 | 3355397 | [
"1759213",
"4959368",
"29981186",
"5698494"
] | scientific_claim_retrieval | scientific |
9b77c063f25de0a05ad23473ff554a89 | mteb/scifact | Surfactin producing cells and exopolymer producing cells cooperate to generate "Van Gogh" bundles that have sliding abilities on specialized media. | From Cell Differentiation to Cell Collectives: Bacillus subtilis Uses Division of Labor to Migrate. The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environmental challenges that they separately cannot. On... | [
"Differentiation of mesenchymal stem cells and embryonic stem cells into steroidogenic cells using steroidogenic factor-1 and liver receptor homolog-1.. Previously, we have demonstrated that mesenchymal stem cells could be differentiated into steroidogenic cells through steroidogenic factor-1 and 8bromo-cAMP treatm... | 1114 | 12824568 | [
"24766509",
"597790",
"34537906",
"10482574"
] | scientific_claim_retrieval | scientific |
8ad5fa6253031a96642aefa7db67a1eb | mteb/scifact | Increased lipolysis leads to higher P38 phosphorylation in adipose tissue. | Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. However, the mechanisms behind these effects are unclear. Here we show that nicotin... | [
"Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.. Uncoupling protein 1 (Ucp1), which is localized in the mitochondrial inner membrane of mammalian brown adipose tissue (BAT), generates heat by uncoupling oxidative phosphorylation. Upon cold exposure or nutritional abun... | 611 | 32408470 | [
"36838958",
"44614949",
"17933691",
"5106691"
] | scientific_claim_retrieval | scientific |
8f106a3f534fd8d6cca4dd5ce0047e38 | mteb/scifact | Type 1 Diabetes is associated with subtle perturbations in T reg development. | Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.. Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in t... | [
"Autoimmunity due to molecular mimicry as a cause of neurological disease. One hypothesis that couples infection with autoimmune disease is molecular mimicry. Molecular mimicry is characterized by an immune response to an environmental agent that cross-reacts with a host antigen, resulting in disease. This hypothes... | 1334 | 11899391 | [
"5476778",
"266641",
"20344442",
"30805636"
] | scientific_claim_retrieval | scientific |
03b1418ce4750dda56031bed2d7ce923 | mteb/scifact | In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells. | Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Pluripotent stem cells exist in naive and primed states, epitomized by mouse embryonic stem cells (ESCs) and the developmentally more advanced epiblast stem cells (EpiSCs; ref. ). In the naive state of ESCs, the genome has an u... | [
"Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst.. Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cel... | 568 | 23418635 | [
"36651210",
"42484543",
"4462419",
"20524091"
] | scientific_claim_retrieval | scientific |
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