id stringlengths 32 32 | source_dataset stringclasses 2
values | query stringlengths 26 249 | positive stringlengths 20 1.8k | negatives listlengths 4 4 | query_id stringlengths 1 4 | positive_id stringlengths 4 9 | negative_ids listlengths 4 4 | task_type stringclasses 2
values | domain stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|
4deb9c565b42b898d61c38741ccac3f0 | mteb/scifact | General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder. | Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study. OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patien... | [
"High prevalence of asthma in cross country skiers.. OBJECTIVES To study the prevalence of asthma (asthma symptoms and bronchial hyperresponsiveness) in Swedish cross country skiers compared with non-skiers and monitor changes in symptoms and bronchial hyperresponsiveness during the year. DESIGN Cross sectional stu... | 454 | 4200695 | [
"2891825",
"33960383",
"27889071",
"8646760"
] | scientific_claim_retrieval | scientific |
448578d535ff1776a1e06b1e1e0b468f | mteb/scifact | miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription. | Roles for MicroRNAs in Conferring Robustness to Biological Processes. Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (m... | [
"Cocoa flavonols and procyanidins promote transforming growth factor-beta1 homeostasis in peripheral blood mononuclear cells.. Evidence suggests that certain flavan-3-ols and procyanidins (FP) can have a positive influence on cardiovascular health. It has been previously reported that FP isolated from cocoa can pot... | 1393 | 12440953 | [
"38712515",
"11557602",
"8856690",
"19358586"
] | scientific_claim_retrieval | scientific |
5bda8c6ee92edf0818eeef34f4f8b8fe | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Editorial overview: Viral immunology: Generating immunity to diverse viral pathogens | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | 79aw3xqw | [
"9807pgmy",
"1kwb0v71",
"5zuij5i3",
"xmjzgqq7"
] | biomedical_literature_retrieval | scientific |
47035f7a305cb499cb5caae2753b55a1 | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Surveillance of Acute Respiratory Infections Using Community-Submitted Symptoms and Specimens for Molecular Diagnostic Testing. Participatory systems for surveillance of acute respiratory infection give real-time information about infections circulating in the community, yet to-date are limited to self-reported syndrom... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | ij9mifov | [
"6324190r",
"ukqvhzws",
"qyb8er14",
"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
8015abb5927410e78d754b33572e3a6e | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Clinical aspects and cytokine response in severe H1N1 influenza A virus infection. INTRODUCTION: The immune responses in patients with novel A(H1N1) virus infection (nvA(H1N1)) are incompletely characterized. We investigated the profile of Th1 and Th17 mediators and interferon-inducible protein-10 (IP-10) in groups wit... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | absjerdt | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
bf4035a1057e5f72a0ffb1b7ed58a320 | mteb/scifact | Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure. | Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M. Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (T... | [
"Subsequent chemotherapy reverses acquired tyrosine kinase inhibitor resistance and restores response to tyrosine kinase inhibitor in advanced non-small-cell lung cancer. BACKGROUND Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can develop acquired resistance to epidermal growth factor rec... | 1346 | 9505402 | [
"9929089",
"23420807",
"25895285",
"29124963"
] | scientific_claim_retrieval | scientific |
fc3e53e3512b59177610c8f457f0b3d3 | mteb/scifact | Antimicrobial agents are more effective due to the pressure of antimicrobial usage. | Resistance to antimicrobials in humans and animals.. Overusing antibiotics is not the only cause and reducing use is not the only solution W arning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to appear in the middle of the last century, and by the 1990s various reports had signalled the... | [
"Drug-resistant Salmonella in the United States: an epidemiologic perspective.. Salmonellosis poses a health problem of large proportions in the United States. Annually, it accounts for more than 40,000 reported cases, 500 deaths, and financial costs well in excess of $50 million. Antimicrobial resistance is increa... | 122 | 31460499 | [
"36497180",
"4695107",
"17438862",
"13000926"
] | scientific_claim_retrieval | scientific |
59a43e83c5dc9ec89815b60f07228e53 | mteb/scifact | Hypocretin neurones suppress panicprone state in rats. | A KEY ROLE FOR OREXIN IN PANIC ANXIETY. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intra... | [
"Modulation of anxiety through blockade of anandamide hydrolysis. The psychoactive constituent of cannabis, Δ9-tetrahydrocannabinol, produces in humans subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous cannabinoids may contribute to the control of emotion. But the variable effec... | 537 | 16056514 | [
"20764484",
"12903921",
"36637129",
"12130690"
] | scientific_claim_retrieval | scientific |
0cfb3724dd524e5943e1b8c33aae5ca6 | mteb/scifact | Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa. | The Molecular Basis for Oat Intolerance in Patients with Celiac Disease. Background Celiac disease is a small intestinal inflammatory disorder characterized by malabsorption, nutrient deficiency, and a range of clinical manifestations. It is caused by an inappropriate immune response to dietary gluten and is treated wi... | [
"Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis.. BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal res... | 867 | 14340571 | [
"10675756",
"1022115",
"878526",
"3981033"
] | scientific_claim_retrieval | scientific |
059cc81f88bfc59f85d8c8e178f9f0a5 | mteb/scifact | BCL-2 activation antagonizes the apoptotic effects of c-Myc. | Antiapoptotic BCL-2 is required for maintenance of a model leukemia.. Resistance to apoptosis, often achieved by the overexpression of antiapoptotic proteins, is common and perhaps required in the genesis of cancer. However, it remains uncertain whether apoptotic defects are essential for tumor maintenance. To test thi... | [
"Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2.. Wedelolactone is a major coumarin of Eclipta prostrata, which is used for preventing liver damage. However the effects of wedelolactone on hepatic fibrosis remained unexplored. The purpose of this study was to demonstrate the a... | 155 | 37549932 | [
"39424916",
"34439544",
"35962023",
"21626639"
] | scientific_claim_retrieval | scientific |
6cfb9b97d5696b6f46063fc0ded8fd8d | mteb/trec-covid | how long does coronavirus remain stable on surfaces? | Issues Concerning Survival of Viruses on Surfaces. Viruses are the causative agents of an estimated 60% of human infections worldwide. The most common viral illnesses are produced by enteric and respiratory viruses. Transmission of these viruses from an infected person or animal to a new host can occur via several rout... | [
"Infections and immunological hazards of allogeneic bone transplantation. Allogeneic transplantation of human cancellous and cortical bone is a controversially discussed concept in trauma and orthopaedic surgery. Biological and immunological arguments support transplantation of autologous material whenever this is ... | 16 | 0e1qn4yv | [
"tle1j3xv",
"wuy3cwhu",
"q5cmwzr8",
"mne96c9i"
] | biomedical_literature_retrieval | scientific |
a872139582b953765e1d3b3fc689c197 | mteb/scifact | Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139. | Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin. The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to human. F... | [
"A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis.. Glycosyl phosphatidylinositols (GPIs) anchor many proteins to the surface of eukaryotic cells and may also serve as sorting signals on proteins and participate in signal transduction. We have isolated ... | 896 | 14338915 | [
"21425864",
"24341590",
"18676539",
"26117607"
] | scientific_claim_retrieval | scientific |
e76bcd0e5f971ac3a3473a4b6e5a09f4 | mteb/scifact | Amitriptyline is an effective treatment for chronic tension-type headaches. | Efficacy and tolerability of amitriptylinoxide in the treatment of chronic tension-type headache: a multi-centre controlled study.. Amitriptyline is the medication of first choice in the treatment of chronic tension-type headache. In 197 patients with chronic tension-type headache (87M and 110F with a mean age of 38 +/... | [
"Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT).. Leukemia in donor cells (donor cell leukemia; DCL) has been reported as a rare but severe complication of allogeneic stem cell transplantation (SCT). Howev... | 108 | 23865182 | [
"11344428",
"3308636",
"44030361",
"24510595"
] | scientific_claim_retrieval | scientific |
8a64686f10604ac7503737cc7a8603de | mteb/trec-covid | how has lack of testing availability led to underreporting of true incidence of Covid-19? | Early real-time estimation of the basic reproduction number of emerging or reemerging infectious diseases in a community with heterogeneous contact pattern: Using data from Hong Kong 2009 H1N1 Pandemic Influenza as an illustrative example. Emerging and re-emerging infections such as SARS (2003) and pandemic H1N1 (2009)... | [
"Solidarity, vulnerability and mistrust: how context, information and government affect the lives of women in times of Zika. BACKGROUND: The public health response to Zika outbreak has mostly focused on epidemiological surveillance, vector control, and individual level preventative measures. This qualitative study ... | 8 | u5o6fq24 | [
"wlbja1gz",
"p2j4m552",
"lwvb6dxc",
"qjab20j6"
] | biomedical_literature_retrieval | scientific |
24276e2d677b81af0418147a1df94e72 | mteb/scifact | Cardiac tissue-resident macrophages directly contribute to electrical activity. | Macrophages Facilitate Electrical Conduction in the Heart. Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elon... | [
"Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases.. Inflammasomes are multiprotein complexes that link pathogen recognition and cellular stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whe... | 228 | 4928057 | [
"16863359",
"7521113",
"22406695",
"7036529"
] | scientific_claim_retrieval | scientific |
f96328ae1d3c9002f4d5b796da35282e | mteb/scifact | Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm. | Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. BACKGROUND The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not been com... | [
"Aortic stiffness, blood pressure progression, and incident hypertension.. CONTEXT Vascular stiffness increases with advancing age and is a major risk factor for age-related morbidity and mortality. Vascular stiffness and blood pressure pulsatility are related; however, temporal relationships between vascular stiff... | 317 | 4506414 | [
"30639847",
"12549585",
"27460509",
"2774906"
] | scientific_claim_retrieval | scientific |
d7572d8046044ee8efd13b81392ee8f8 | mteb/scifact | Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments. | H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.. Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight-cell SCNT ... | [
"Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome. The ectopic expression of transcription factors can reprogram cell fate, yet it is unknown how the initial binding of factors to the genome relates functionally to the binding seen in the minority of cells t... | 1034 | 4547102 | [
"18998807",
"14225271",
"8150638",
"8185080"
] | scientific_claim_retrieval | scientific |
fe8e3289fd777f0c5fbce0f687398acd | mteb/scifact | RUNX1 is downregulated or mutated in TLX1 T-ALL. | Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to deciphe... | [
"Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification.. CBFbeta is the non-DNA binding subunit of the core binding factors (CBFs). Mice with reduced CBFbeta levels display profound, early defects in T-cell but not B-cell development. H... | 1009 | 1982286 | [
"28206748",
"9310407",
"43587663",
"5132358"
] | scientific_claim_retrieval | scientific |
bcd3218f04100e128427fb08908a5e08 | mteb/scifact | Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung. | Memory CD4+ T cells induce innate responses independently of pathogen. Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses. W... | [
"Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection.. In this report, we demonstrate that CD28(-/-) mice are severely impaired in the initial expansio... | 1347 | 19005293 | [
"40473317",
"12100963",
"40365566",
"23912923"
] | scientific_claim_retrieval | scientific |
124e7a11d452731d648537cf53d7caee | mteb/trec-covid | how does the coronavirus respond to changes in the weather | The association between temperature, rainfall and humidity with common climate-sensitive infectious diseases in Bangladesh. Bangladesh is one of the world’s most vulnerable countries for climate change. This observational study examined the association of temperature, humidity and rainfall with six common climate-sensi... | [
"Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression. The mitochondrial protein repertoire varies depending on the cellular state. Protein component modifications caused by mitochondrial DNA (mtDNA) depletion are related to a wide range of human diseases; however, little is know... | 2 | qm8kalyt | [
"9egy68c0",
"4cjlolp6",
"7o6htufh",
"upjhmfca"
] | biomedical_literature_retrieval | scientific |
d2277bce467a4fde707737813052151b | mteb/scifact | Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers. | Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst.. Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cells ha... | [
"TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.. Human embryonic stem cells (hESCs) self-renew indefinitely and give rise to derivatives of all three primary germ layers, yet little is known about the signaling cascades that govern their pluripotent c... | 531 | 36651210 | [
"26374799",
"4427392",
"19770974",
"36398420"
] | scientific_claim_retrieval | scientific |
53789f68b4a00f99e1cbf0312bae8076 | mteb/scifact | Phase information is useful for predicting donor-recipient matches in organ transplantation. | MHC Haplotype Matching for Unrelated Hematopoietic Cell Transplantation. Background Current criteria for the selection of unrelated donors for hematopoietic cell transplantation (HCT) include matching for the alleles of each human leukocyte antigen (HLA) locus within the major histocompatibility complex (MHC). Graft-ve... | [
"Call to Develop a Standard Acquisition Charge Model for Kidney Paired Donation. We propose a Medicare Demonstration Project to develop a standard acquisition charge for kidney paired donation. A new payment strategy is required because Medicare and commercial insurance companies may not directly pay living donor c... | 942 | 11527199 | [
"41774099",
"31634628",
"7583161",
"14647747"
] | scientific_claim_retrieval | scientific |
598931f2f646945faac977db85d1ecb1 | mteb/scifact | The G34R/V mutation does not create a hypomethylated phenotype at the H3K36 histone. | ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. Recognition of modified histones by ‘reader’ proteins plays a critical role in the regulation of chromatin. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the transcribed regions after RNA polymerase II elongation... | [
"Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. Over 70% of diffuse intrinsic pediatric gliomas, an aggressive brainstem tumor, harbor heterozygous mutations that create a K27M amino acid substitution (methionine replaces lysine 27) in the tail of histone H3.3. The role... | 1165 | 4455466 | [
"12887068",
"4312169",
"14475235",
"18694784"
] | scientific_claim_retrieval | scientific |
ed213e5487db76e6389ec16644b274df | mteb/scifact | p16INK4A degradation is encoded by CDKN2A. | Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model. Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe a luciferase knockin mouse (p16(LUC)), which faithfully reports expression of p16(INK4a), a tumor suppressor and aging biomarker. Lifelong assessmen... | [
"Inhibition of HDM2 and activation of p53 by ribosomal protein L23.. The importance of coordinating cell growth with proliferation has been recognized for a long time. The molecular basis of this relationship, however, is poorly understood. Here we show that the ribosomal protein L23 interacts with HDM2. The intera... | 1398 | 17717391 | [
"2582169",
"36708463",
"12207340",
"24923605"
] | scientific_claim_retrieval | scientific |
cf837e14fe9a3edb2a5715f16ed35cc5 | mteb/scifact | Bariatric surgery increases rates of colorectal cancer. | Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large... | [
"Ribosome biogenesis: Achilles heel of cancer?. It is long been known that cancer and non-cancer cells can be distinguished on the basis of their nucleolar morphologies. As early as the 19th century, it was reported that cancer cells have larger and more irregularly shaped nucleoli. Since then, pathologists have us... | 164 | 5824985 | [
"6670101",
"24974080",
"8963413",
"7165938"
] | scientific_claim_retrieval | scientific |
009cee775f1a272baac251fe3f3b1b59 | mteb/scifact | The myocardial cell lineage originally develops from cardiac progenitors of exclusively endodermal origin. | Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.. Cardiovascular disease is a leading cause of death worldwide. The limited capability of heart tissue to regenerate has prompted methodological developments for creating de novo cardiomyocytes, both in vitro and ... | [
"Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-beta.. Lineage analysis studies in the avian embryo have identified two types of smooth muscle cells (SMCs) in the tunica media ... | 1239 | 21387297 | [
"32797183",
"6148876",
"4020950",
"51865482"
] | scientific_claim_retrieval | scientific |
3cfa64ef6820a78283c02ed1158937c3 | mteb/scifact | Depletion of nitric oxide is responsible for vasospasm. | Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage.. CONTEXT Delayed cerebral vasospasm causes permanent neurological deficits or death in at least 15% of patients following otherwise successful treatment for ruptured intracranial aneurysm. Decreased bioavailability of... | [
"Crucial Role of Interferon Consensus Sequence Binding Protein, but neither of Interferon Regulatory Factor 1 nor of Nitric Oxide Synthesis for Protection Against Murine Listeriosis. Listeria monocytogenes is widely used as a model to study immune responses against intracellular bacteria. It has been shown that neu... | 334 | 25079962 | [
"7155555",
"6397191",
"46743299",
"6580081"
] | scientific_claim_retrieval | scientific |
6216fea135d95069362545aa93b0cc14 | mteb/scifact | Lipopolysaccharides have an inflammation independent effect on kidney barrier function. | Modification of kidney barrier function by the urokinase receptor. Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. Here we show that induction of ur... | [
"Pleiotropic effects of statins.. Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are beneficial in the primary and secondary prevention of coronary heart disease. However, the overall benefits observed with statins appear to be greater than what might be expected from changes... | 696 | 16355392 | [
"21557614",
"18852643",
"3545805",
"4427060"
] | scientific_claim_retrieval | scientific |
f8bb067339e052fa0c763966eccaa3d9 | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Role of brain renin angiotensin system in neurodegeneration: An update. Renin angiotensin system (RAS) is an endocrine system widely known for its physiological roles in electrolyte homeostasis, body fluid volume regulation and cardiovascular control in peripheral circulation. However, brain RAS is an independent form ... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | ewb6ozbx | [
"mx4t6s6n",
"r8fmq65g",
"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
8cf1a65baa6d69dd18e46a923b149970 | mteb/trec-covid | what is known about those infected with Covid-19 but are asymptomatic? | (18)F-Fluorodeoxyglucose Uptake in Patient With Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (Coronavirus Disease 2019) Referred to Positron Emission Tomography/Computed Tomography for NSCLC Restaging | [
"Functional community structure of African monodominant Gilbertiodendron dewevrei forest influenced by local environmental filtering. Monodominant patches of forest dominated by Gilbertiodendron dewevrei are commonly found in central African tropical forests, alongside forests with high species diversity. Although ... | 27 | sie6gv8k | [
"clirh04i",
"mj63cvwe",
"yc8rjjyf",
"v8lpw4r7"
] | biomedical_literature_retrieval | scientific |
3d830fc043993a90015dd290ee56b357 | mteb/scifact | Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle. | Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps.. BACKGROUND Histone deimination regulates gene function and contributes to antimicrobial response, allowing the formation of neutrophil extracellular traps (NETs). Deiminated proteins are targ... | [
"The role of neutrophils in the pathogenesis of systemic lupus erythematosus.. PURPOSE OF REVIEW Recent discoveries implicate neutrophils as important regulators of innate and adaptive immunity and in the development of organ damage in systemic autoimmune diseases, including systemic lupus erythematosus (SLE). RECE... | 263 | 30041340 | [
"28149602",
"36089763",
"43054703",
"2236768"
] | scientific_claim_retrieval | scientific |
b5ff1c67a8ac15322175b90616e59bce | mteb/trec-covid | how has COVID-19 affected Canada | Acute care utilization due to hospitalizations for pediatric lower respiratory tract infections in British Columbia, Canada. BACKGROUND: Pediatric LRTI hospitalizations are a significant burden on patients, families, and healthcare systems. This study determined the burden of pediatric LRTIs on hospital settings in Bri... | [
"Effects of memory on the shapes of simple outbreak trees. Genomic tools, including phylogenetic trees derived from sequence data, are increasingly used to understand outbreaks of infectious diseases. One challenge is to link phylogenetic trees to patterns of transmission. Particularly in bacteria that cause chroni... | 9 | jb8228vn | [
"mcdfcc8v",
"78395e3t",
"iwu022jh",
"44mvuunh"
] | biomedical_literature_retrieval | scientific |
da2ded10ef1b22c7021a4310d5fe56d8 | mteb/scifact | Transplanted human glial progenitor cells can mature in their host animal. | Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.. Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution. To assess the cell-autonomous and species-selectiv... | [
"Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.. The long-term goal of nuclear transfer or alternative reprogramming approaches is to create patient-specific donor cells for transplantation therapy, avoiding immunoreje... | 1322 | 16284655 | [
"14192687",
"5476778",
"23423230",
"13969173"
] | scientific_claim_retrieval | scientific |
9a2efc4ba836a2e73d31a4781d8dd084 | mteb/scifact | Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth. | Effects of exercise intensity on cardiovascular fitness, total body composition, and visceral adiposity of obese adolescents.. BACKGROUND Little is known about how the intensity of exercise influences cardiovascular fitness and body composition, especially in obese adolescents. OBJECTIVE Our goal was to determine the e... | [
"Comparison of Maximal Oxygen Consumption Between Black and White Prepubertal and Pubertal Children. The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between two selected groups of black and white children and whether a difference existed to determine whether i... | 945 | 4463588 | [
"18537148",
"11201004",
"24746892",
"8595678"
] | scientific_claim_retrieval | scientific |
013cd86638974fc798be2bf0c2f42729 | mteb/scifact | Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers. | Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.. Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture. Here w... | [
"TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.. Human embryonic stem cells (hESCs) self-renew indefinitely and give rise to derivatives of all three primary germ layers, yet little is known about the signaling cascades that govern their pluripotent c... | 531 | 25413327 | [
"26374799",
"4427392",
"19770974",
"36398420"
] | scientific_claim_retrieval | scientific |
ddc4191a9170e788786d60004ffe122a | mteb/scifact | NAC inhibits the generation of angiotensin-converting enzyme. | Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial.. CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography scanning... | [
"Comparative risk of new-onset diabetes mellitus for antihypertensive drugs: A network meta-analysis.. New-onset diabetes mellitus (NOD) refers to forms of diabetes mellitus that develop during the therapeutic processes of other diseases such as hypertension. This study has been conducted in a network meta-analysis... | 828 | 4678846 | [
"43417006",
"26199970",
"5573975",
"38944245"
] | scientific_claim_retrieval | scientific |
8b119b639afd9ec57914efad77d96101 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | ZIKV Infection Induces an Inflammatory Response but Fails to Activate Types I, II, and III IFN Response in Human PBMC. The recent epidemic in the Americas caused by Zika virus (ZIKV), Asian lineage, spurred the research towards a better understanding of how ZIKV infection affects the host immune response. The aim of th... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | srk7b83b | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
40e50986fd490bf8348efcbb2da449d0 | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Detection of respiratory syncytial virus infection in nasal aspirate samples by flow cytometry. Hypotheses: (i) Flow cytometry has the potential for rapid detection of respiratory viral antigens. (ii) This technique can be applied to viral diagnosis in clinical samples. Objectives and study design: (i) To study the ide... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | 621ngghv | [
"6324190r",
"ukqvhzws",
"qyb8er14",
"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
a110ef6e2f94dd528e43b7fc1f252f00 | mteb/scifact | The morphology change from large white adipocytes to small brown adipocytes is a sign of decreased energy expenditure potential in white adipose tissue. | Human ‘brite / beige’ adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice. Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is also found outside classical brow... | [
"Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environments. In the prevailing model of thermogenesis, when the... | 1235 | 17973161 | [
"4319174",
"26902591",
"18064113",
"32955023"
] | scientific_claim_retrieval | scientific |
d66f45d11386bc31ab82a358f9cdb391 | mteb/trec-covid | what is known about an mRNA vaccine for the SARS-CoV-2 virus? | Balancing Expediency and Scientific Rigor in Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Development | [
"Gold nanoparticles for preparation of antibodies and vaccines against infectious diseases. Introduction: Vaccination remains very effective in stimulating protective immune responses against infections. An important task in antibody and vaccine preparation is to choose an optimal carrier that will ensure a high im... | 50 | g0yxf99c | [
"1tn3a4qs",
"299oohbp",
"msmq91d2",
"184kmuiy"
] | biomedical_literature_retrieval | scientific |
5a465c2997dbd006d0dce2644d778b95 | mteb/scifact | Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK. | Ecological analysis of ethnic differences in relation between tuberculosis and poverty.. OBJECTIVE To examine the effect of ethnicity on the relation between tuberculosis and deprivation. DESIGN Retrospective ecological study comparing incidence of tuberculosis in white and south Asian residents of the 39 electoral war... | [
"Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care.. OBJECTIVES To investigate incidence, mortality and case survival trends for cancer of unknown primary site (CUP) and consider clinical implications. METHOD Sou... | 1327 | 24241932 | [
"20610390",
"2097256",
"22963769",
"13900610"
] | scientific_claim_retrieval | scientific |
7d6842580a704dc68db8d7a143dd52de | mteb/scifact | A deficiency of vitamin B12 decreases blood levels of homocysteine. | Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.. BACKGROUND Homocysteine is a risk factor for coronary artery disease (CAD), although a causal relation remains to be proven. The importance of determining direct causality rests in the fact ... | [
"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial.. CONTEXT High plasma homocysteine levels are a risk factor for mortality and vascular disease in observational studies of patients with chronic kidney dis... | 35 | 5152028 | [
"33409100",
"3034412",
"18557974",
"7116734"
] | scientific_claim_retrieval | scientific |
f8a4ef27cd0530bc2ad992df4599978d | mteb/scifact | 61% of colorectal cancer patients are diagnosed with regional or distant metastases. | Relation between Medicare screening reimbursement and stage at diagnosis for older patients with colon cancer.. CONTEXT Medicare's reimbursement policy was changed in 1998 to provide coverage for screening colonoscopies for patients with increased colon cancer risk, and expanded further in 2001 to cover screening colon... | [
"Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial. BACKGROUND Elderly and frail patients with cancer, although often treated with chemotherapy, are under-represented in clinical trials. We designed FOCUS2 to investigate redu... | 18 | 22942787 | [
"15476777",
"10958594",
"2140497",
"7852582"
] | scientific_claim_retrieval | scientific |
2c8e05bd2d2f472fb30b077118322419 | mteb/scifact | 1-1% of colorectal cancer patients are diagnosed with regional or distant metastases. | Relation between Medicare screening reimbursement and stage at diagnosis for older patients with colon cancer.. CONTEXT Medicare's reimbursement policy was changed in 1998 to provide coverage for screening colonoscopies for patients with increased colon cancer risk, and expanded further in 2001 to cover screening colon... | [
"Cancer treatment and survivorship statistics, 2014.. The number of cancer survivors continues to increase due to the aging and growth of the population and improvements in early detection and treatment. In order for the public health community to better serve these survivors, the American Cancer Society and the Na... | 4 | 22942787 | [
"25121903",
"5641851",
"10958594",
"24581365"
] | scientific_claim_retrieval | scientific |
35bc34beb6a73ba31d5e0f3302d46dc4 | mteb/trec-covid | what type of hand sanitizer is needed to destroy Covid-19? | Disinfection Agents and Antiseptics. Germicidal agents are nonspecific antimicrobial agents that are too toxic to be administered internally but are safe and effective when used topically. When applied to living tissue (e.g., the skin), they are termed antiseptics. When applied to inanimate objects (e.g., environmental... | [
"Airspace-Occupying Diseases. Diseases of the air space of the lung share many common findings and presentation that it makes more sense to be grouped together in a differential diagnosis. The common imaging finding is usually as a lung infiltrate or consolidation of some type of distribution or another. Trying to ... | 19 | 4d2ajf65 | [
"1ses23oz",
"vmcy38wt",
"mmd8ru3r",
"aet9nitv"
] | biomedical_literature_retrieval | scientific |
f5f312aaf840c791f4a862b93e502495 | mteb/scifact | Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain | Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor. The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that n... | [
"The Ran GTPase regulates mitotic spindle assembly. Ran is an abundant nuclear GTPase with a clear role in nuclear transport during interphase but with roles in mitotic regulation that are less well understood. The nucleotide-binding state of Ran is regulated by a GTPase activating protein, RanGAP1, and by a guanin... | 481 | 14706752 | [
"14119470",
"25251625",
"23078022",
"8093935"
] | scientific_claim_retrieval | scientific |
60c6a87965dc6c4d64ebf3da1ae17a80 | mteb/trec-covid | what are the transmission routes of coronavirus? | Networks and the Epidemiology of Infectious Disease. The science of networks has revolutionised research into the dynamics of interacting elements. It could be argued that epidemiology in particular has embraced the potential of network theory more than any other discipline. Here we review the growing body of research ... | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | 8seknsaq | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
9418abda56e7851453a7ad48e768533c | mteb/scifact | H4 G94P proteins induce chromatin assembly, which increases free histones. | Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis. Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stop... | [
"Structure of Actin-related protein 8 and its contribution to nucleosome binding. Nuclear actin-related proteins (Arps) are subunits of several chromatin remodelers, but their molecular functions within these complexes are unclear. We report the crystal structure of the INO80 complex subunit Arp8 in its ATP-bound f... | 484 | 14637235 | [
"14155726",
"1259280",
"8548635",
"213017"
] | scientific_claim_retrieval | scientific |
ecdaebc08b8e2ef3266e8b92d64d68a6 | mteb/scifact | Antidepressants reduce the severity of migraines. | Tricyclic antidepressants and headaches: systematic review and meta-analysis. OBJECTIVE To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches. DESIGN Meta-analysis. DATA SOURCES Medline, Embase, the Cochrane Trials Registry, an... | [
"Does socioeconomic status matter? A meta-analysis on parent training effectiveness for disruptive child behavior.. Disadvantaged family socioeconomic status (SES) is often assumed to diminish parent training program effectiveness. In examining effects of SES, influences of initial problem severity have been largel... | 120 | 14606752 | [
"25493293",
"26902591",
"9614443",
"13883546"
] | scientific_claim_retrieval | scientific |
b3151b5bb8c22cd1e8fdc87f6775564d | mteb/scifact | Rising temperatures caused by global warming lowers the risk of dengue fever transmission. | Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages. BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and envi... | [
"Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We ... | 1053 | 18816720 | [
"2097256",
"13882658",
"8063697",
"27866735"
] | scientific_claim_retrieval | scientific |
141769491777ccc53662504c10374dcf | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection. BACKGROUND: Respiratory syncytial virus (RSV) infects the lung epithelium where it stimulates the production of numerous host cytokines that are associated with disease burden and acute lung injury. Characterizing the host cytoki... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | vhiwrhkb | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
1e3174a0b09e71665f05779c94262914 | mteb/scifact | Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments. | Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. OBJECTIVE Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant extracellular matrix compone... | [
"Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity. BACKGROUND Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to re... | 620 | 2565138 | [
"1805641",
"1171121",
"11246427",
"9122283"
] | scientific_claim_retrieval | scientific |
3c113c9f9ce6c53522eaf84cce9f95b4 | mteb/scifact | V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress. | Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models. The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer metabolism has led ... | [
"DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress. The stress-activated kinase JNK mediates key cellular responses to oxidative stress. Here we show that DAP kinase (DAPk), a cell death promoting Ser/Thr protein kinase, plays a main role in oxidative stress-induce... | 1355 | 5256564 | [
"24185667",
"14496749",
"1454773",
"4911006"
] | scientific_claim_retrieval | scientific |
fe89709eee38ae7d146658b4beec09cd | mteb/trec-covid | how does the coronavirus respond to changes in the weather | Let the sun shine in: effects of ultraviolet radiation on invasive pneumococcal disease risk in Philadelphia, Pennsylvania. BACKGROUND: Streptococcus pneumoniae is a common cause of community acquired pneumonia and bacteremia. Excess wintertime mortality related to pneumonia has been noted for over a century, but the s... | [
"Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression. The mitochondrial protein repertoire varies depending on the cellular state. Protein component modifications caused by mitochondrial DNA (mtDNA) depletion are related to a wide range of human diseases; however, little is know... | 2 | gbdaad4l | [
"9egy68c0",
"4cjlolp6",
"7o6htufh",
"upjhmfca"
] | biomedical_literature_retrieval | scientific |
05e08623e2fff217f5170b5a4df6b947 | mteb/scifact | LRBA promotes CTLA - 4 recycling. | Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family in which five individuals presented with a complex, aut... | [
"Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans.. RNA interference (RNAi) is heritable in Caenorhabditis elegans; the progeny of C. elegans exposed to dsRNA inherit the ability to silence genes that were targeted by RNAi in the previous generation. Here we investigate the mechanism of RNA... | 677 | 857189 | [
"9539753",
"18489989",
"20388894",
"3113630"
] | scientific_claim_retrieval | scientific |
2fe178450e6e48acb9057ce133925ad2 | mteb/scifact | Deltex has no known interactions with eIF3f. | The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation. Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secret... | [
"A Whole Brain Staining, Embedding, and Clearing Pipeline for Adult Zebrafish to Visualize Cell Proliferation and Morphology in 3-Dimensions. The field of macro-imaging has grown considerably with the appearance of innovative clearing methods and confocal microscopes with lasers capable of penetrating increasing ti... | 330 | 9505448 | [
"9629682",
"7386360",
"16905344",
"4336849"
] | scientific_claim_retrieval | scientific |
b02bc3c3a7c29dd0fee9bcb660668529 | mteb/trec-covid | are there any clinical trials available for the coronavirus | Drug repurposing strategies for COVID-19. COVID-19 has now been declared a pandemic and new treatments are urgently needed as we enter a phase beyond containment. Developing new drugs from scratch is a lengthy process, thus impractical to face the immediate global challenge. Drug repurposing is an emerging strategy whe... | [
"Diagnosis and Management of Tuberculous Pericarditis: What Is New?. PURPOSE OF REVIEW: This review provides an update on the immunopathogenesis of tuberculous pericarditis (TBP), investigations to confirm tuberculous etiology, the limitations of anti-tuberculous therapy (ATT), and recent efficacy trials. RECENT FI... | 17 | nbjili3v | [
"pakh49dy",
"4d33eg4e",
"3fdptled",
"aqv7xhng"
] | biomedical_literature_retrieval | scientific |
d8c388a156105780f4d654105e2dfbbd | mteb/scifact | Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis. | Cyclin A Regulates Kinetochore-Microtubules to Promote Faithful Chromosome Segregation. The most conspicuous event in the cell cycle is the alignment of chromosomes in metaphase. Chromosome alignment fosters faithful segregation through the formation of bi-oriented attachments of kinetochores to spindle microtubules. N... | [
"Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Cyclin A2 activates the cyclin-dependent kinases Cdk1 and Cdk2 and is expressed at elevated levels from S phase until early mitosis. We found that mutant mice that cannot elevate cyclin A2 are chromosomally unstable and tumor-prone. Underlyi... | 296 | 4398832 | [
"45875990",
"600808",
"8087082",
"14591894"
] | scientific_claim_retrieval | scientific |
4628d9707035b3c7c07f63d5449ceaef | mteb/scifact | Stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin. | Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality. Importance Although non–vitamin K antagonist oral anticoagulants (NOACs) are increasingly used to prevent thromboembolic disease, there are limited data on NOAC-... | [
"Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry.. BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care... | 1103 | 3898784 | [
"5884524",
"6158879",
"12561083",
"4687948"
] | scientific_claim_retrieval | scientific |
0ef00f2e69e41141c15cbd67c0f1a98c | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Viral and bacterial pathogens identification in children hospitalised for severe pneumonia and parapneumonic empyema. Pneumonia is caused by respiratory bacteria and/or viruses. Little is known if co-infections are an aggravating factor in hospitalised children with severe pneumonia. We studied the impact of respirator... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | beqbgots | [
"6324190r",
"ukqvhzws",
"qyb8er14",
"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
51d1ebdce3bd612721f6cccd588ed659 | mteb/scifact | The proliferative capacity of progenitors is regulated cell-autonomously. | 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.. Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability between humans and other animals. Here we compare cortical pr... | [
"Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.. Embryonic stem (ES) cells homozygous for a Shp-2 mutation (Shp-2(Delta46-110)) demonstrate leukemia inhibitory factor (LIF) hypersensitivity and increased LIF-stimulated phosphorylation of ... | 1255 | 16939583 | [
"18489989",
"39851630",
"19912367",
"20186814"
] | scientific_claim_retrieval | scientific |
e0c150f81a77d941e31eb84f5d58bc62 | mteb/scifact | Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma. | Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergic dis... | [
"Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review.. There are two main families of polyunsaturated fatty acids (PUFAs), the n-6 and the n-3 families. It has been suggested that there is a causal relationship between n-6 PUFA ... | 710 | 22442133 | [
"24269361",
"20148808",
"3866315",
"20672596"
] | scientific_claim_retrieval | scientific |
fbb842aef72c025309070c82bc913181 | mteb/scifact | Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos. | A chikungunya fever vaccine utilizing an insect-specific virus platform. Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines. In contrast, the inability ... | [
"Production of cloned mice and ES cells from adult somatic cells by nuclear transfer: how to improve cloning efficiency?. Although it has now been 10 years since the first cloned mammals were generated from somatic cells using nuclear transfer (NT), most cloned embryos usually undergo developmental arrest prior to ... | 772 | 24922825 | [
"22490293",
"35993767",
"12670680",
"20148808"
] | scientific_claim_retrieval | scientific |
6d483c7ec5892cabb0a80e9bdde4a6fe | mteb/scifact | Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates. | Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.. Deamidation of N-terminal Gln by Nt(Q)-amidase, an N-terminal amidohydrolase, is a part of the N-end rule pathway of protein degradation. We detected the activity of Nt(Q)-amidase, termed Ntaq1, in mouse tissues, purified Ntaq1 from bovine b... | [
"Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.. G protein-coupled receptors (GPCRs) from the secretin-like (class B) family are key players in hormonal homeostasis and are important drug targets for the treatment of metabolic disorders and neuronal diseas... | 429 | 36540079 | [
"31107919",
"10169908",
"35531883",
"12622860"
] | scientific_claim_retrieval | scientific |
6496537064aeb71bae0009bae41f60cc | mteb/scifact | Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies. | NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.. The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutroph... | [
"Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity. Autoantibodies to DNA and histones (chromatin) are the defining antigen specificity in systemic lupus erythematosus (SLE) and related musculoskeletal disorders but the mechanisms responsible for their induction remain mysterio... | 264 | 11328820 | [
"14853989",
"1049501",
"28015516",
"36089763"
] | scientific_claim_retrieval | scientific |
905b0745bfc761c52242dd28751bdf83 | mteb/scifact | Self-advocacy training is effective at decreasing homelessness. | Mental health problems of homeless children and families: longitudinal study.. OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 ye... | [
"Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking.. Alcohol dependence is a disease that impacts millions of individuals worldwide. There has been some progress with pharmacotherapy for alcohol-dependent individuals; however, there r... | 1070 | 25649714 | [
"24019260",
"11230569",
"14205246",
"28910120"
] | scientific_claim_retrieval | scientific |
8ac8eb24faa42e5372dc46da855f0b4a | mteb/trec-covid | what are the guidelines for triaging patients infected with coronavirus? | How Can Emergency Departments Better Prepare for Emerging Infectious Disease Threats? A Returned Traveler With Fever Walks Into Triage… | [
"2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients. BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung disease... | 11 | 8jyqp4hq | [
"jzlouns7",
"jc443w2a",
"9807pgmy",
"0smru5k2"
] | biomedical_literature_retrieval | scientific |
213b037998781a673c9e7f77ef0d5d03 | mteb/scifact | Microcin J25 encourages nucleoside triphosphate (NTP) binding. | Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.. The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP). Biochemical results indicate that inhibition of transcription occurs at the level ... | [
"A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.. Recently, mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptas... | 787 | 4740447 | [
"6426919",
"2319305",
"25014337",
"11922370"
] | scientific_claim_retrieval | scientific |
44933c777b6ee9e78c7e629e07166d88 | mteb/scifact | Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs). | Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.. CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs. However, whether pharmacist participation in the ICU at ... | [
"Adverse Events Associated With the Treatment of Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis.. Multidrug-resistant tuberculosis (MDR-TB) is a growing public health problem. Due to long duration of therapy and concurrent use of multiple second-line drugs, adverse drug events (ADEs) are re... | 600 | 12258338 | [
"11254040",
"42404093",
"37628989",
"4910408"
] | scientific_claim_retrieval | scientific |
acb14c62d593d3d3c261ac43f7e821c0 | mteb/scifact | Pharmacist attendance at ward rounds reduces adverse events in wards. | Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.. CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs. However, whether pharmacist participation in the ICU at ... | [
"Ethnographic study of incidence and severity of intravenous drug errors.. OBJECTIVES To determine the incidence and clinical importance of errors in the preparation and administration of intravenous drugs and the stages of the process in which errors occur. DESIGN Prospective ethnographic study using disguised obs... | 941 | 12258338 | [
"16495649",
"997143",
"46266579",
"39892135"
] | scientific_claim_retrieval | scientific |
dd4818001cbc605dcdcd7082dbac099f | mteb/scifact | Eliminating the last sporadic cases of malaria requires considerable funding. | Costs and financial feasibility of malaria elimination. The marginal costs and benefits of converting malaria programmes from a control to an elimination goal are central to strategic decisions, but empirical evidence is scarce. We present a conceptual framework to assess the economics of elimination and analyse a cent... | [
"The feasibility of malaria elimination in South Africa. BACKGROUND Following the last major malaria epidemic in 2000, malaria incidence in South Africa has declined markedly. The decrease has been so emphatic that South Africa now meets the World Health Organization (WHO) threshold for malaria elimination. Given t... | 376 | 22401061 | [
"5710820",
"23639838",
"30919024",
"7485455"
] | scientific_claim_retrieval | scientific |
6377bba9cd6712342aa0647392c3f871 | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Development and application of a novel ELISA for detecting antibodies against group I fowl adenoviruses. Since 2015, outbreaks of hepatitis-hydropericardium syndrome (HPS) caused by a novel genotype of fowl adenovirus 4 (FAdV-4) infection have created serious economic losses in China. Given that other serotypes of hype... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | ovjdzyxv | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
d25d1723a44e85265823c0232d518a45 | mteb/scifact | Rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder. | Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study. OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patien... | [
"Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial.. BACKGROUND Angiotensin receptor blockers (ARB) and angiotensin converting enzyme (ACE) inhibitors are known to reduce proteinuria. Their combination ... | 1056 | 4200695 | [
"25816994",
"2891825",
"3619931",
"24700152"
] | scientific_claim_retrieval | scientific |
6065c695e64a1d3cf064926a4a6a1906 | mteb/scifact | Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis. | Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis. Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation, apoptosis and cellular transitions. Here we show that the ... | [
"Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.. Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in ... | 671 | 5573975 | [
"40349336",
"368506",
"22800314",
"11428884"
] | scientific_claim_retrieval | scientific |
5ae1f3a3c4d626a80686ec93e4e9b936 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Diagnosis of influenza viruses with special reference to novel H1N1 2009 influenza virus. On 15 April and 17 April 2009, novel swineorigin influenza A (H1N1) virus was identifi ed in specimens obtained from two epidemiologically unlinked patients in the United States. The ongoing outbreak of novel H1N1 2009 influenza (... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | ecgyz78q | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
ad2413ba29cff6064224c3a6852faf34 | mteb/scifact | 40mg/day dosage of folic acid and 2mg/day dosage of vitamin B12 does not affect chronic kidney disease (CKD) progression. | Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial.. CONTEXT High plasma homocysteine levels are a risk factor for mortality and vascular disease in observational studies of patients with chronic kidney disease.... | [
"Randomized trial of folic acid supplementation and serum homocysteine levels.. BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (re... | 12 | 33409100 | [
"11705328",
"3090454",
"43557480",
"19464037"
] | scientific_claim_retrieval | scientific |
4c384cc22d254b8c9c745ace6f0cb282 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Influenza, Measles, SARS, MERS, and Smallpox. Influenza, measles, SARS, MERS, and smallpox illnesses are caused by highly infectious viral pathogens that induce critical illness. These biologically diverse viruses enter and replicate within host cells triggering viral- and host-mediated damage that results in pneumonia... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | k8m2xz0e | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
157276b1350606ea995bc14f6ea7f409 | mteb/scifact | AZT given with ribavirin increases anemia. | Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection.. CONTEXT Use of antiretroviral drugs, including protease inhibitors, for treatment of human immunodeficiency virus (HIV) infection has been anecdotally associated ... | [
"Health-Related Quality of Life as Measured with EQ-5D among Populations with and without Specific Chronic Conditions: A Population-Based Survey in Shaanxi Province, China. INTRODUCTION The aim of this study was to examine health-related quality of life (HRQoL) as measured by EQ-5D and to investigate the influence ... | 66 | 14806256 | [
"463533",
"24541180",
"42373943",
"38712515"
] | scientific_claim_retrieval | scientific |
5d44b58ca929f680b07514289b2f7b61 | mteb/scifact | Smc5/6 engagment halts the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding. | ATPase-Dependent Control of the Mms21 SUMO Ligase during DNA Repair. Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromati... | [
"The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.. The receptor Notch and its ligands of the Delta/Serrate/LAG2 (DSL) family are the central components in the Notch pathway, a fundamental cell signaling system that regulates pattern... | 1090 | 17628888 | [
"6268106",
"143251",
"393001",
"23513818"
] | scientific_claim_retrieval | scientific |
3c338bda0f66d36a07ebe530a256b269 | mteb/scifact | Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations. | The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.. Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as meas... | [
"Oct4-Induced Pluripotency in Adult Neural Stem Cells. The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse and human fibroblasts. We previously described direct reprogramming of adult mouse neural stem cells (NSCs) by Oct4 and either Klf4 or c-Myc. NSCs endogenously express S... | 369 | 6826100 | [
"1630949",
"24530633",
"8290760",
"4405194"
] | scientific_claim_retrieval | scientific |
bb9899a0a7e888fba8a8918a3e851212 | mteb/trec-covid | what drugs have been active against SARS-CoV or SARS-CoV-2 in animal studies? | Nonhuman Primate Models of Immunosenescence. Due to a dramatic increase in life expectancy, the number of individuals aged 65 and older is rapidly rising. This presents considerable challenges to our health care system since advanced age is associated with a higher susceptibility to infectious diseases due to immune se... | [
"Emerging Animal Coronaviruses: First SARS and Now MERS. The first major pandemic of the new millennium that arose from southern China in 2002 was of zoonotic origin from wild game animals, called severe acute respiratory syndrome [SARS]. The culprit was determined to be a coronavirus of animal origin [SARS-CoV]. T... | 5 | j0exlr7c | [
"3114rz8f",
"qilqtvzt",
"zrobpop6",
"isvkp4d1"
] | biomedical_literature_retrieval | scientific |
ba0b46130aa77d8815206e61d5016fc9 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Forecasting the 2017/2018 seasonal influenza epidemic in England using multiple dynamic transmission models: a case study. BACKGROUND: Since the 2009 A/H1N1 pandemic, Public Health England have developed a suite of real-time statistical models utilising enhanced pandemic surveillance data to nowcast and forecast a futu... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | fdwrrpnl | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
c2e0dfc5d61c5858068402c5a5c1e628 | mteb/scifact | The most prevalent adverse events to Semaglutide are cardiovascular. | Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial. Importance Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatment of type 2 diabetes and are all currently available as an... | [
"Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association.. Angiotensin converting enzyme (ACE) inhibitors are now one ... | 1237 | 3654468 | [
"6157837",
"24150328",
"6397191",
"75636923"
] | scientific_claim_retrieval | scientific |
63733658d82598ccc67a2fee17da1d3a | mteb/trec-covid | how long can the coronavirus live outside the body | Infection prevention and control in ultrasound - best practice recommendations from the European Society of Radiology Ultrasound Working Group. OBJECTIVES: The objective of these recommendations is to highlight the importance of infection prevention and control in ultrasound (US), including diagnostic and interventiona... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | qnya50mf | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
cfb67917d6865ab50b02ee8b0c69cec5 | mteb/trec-covid | how does the coronavirus respond to changes in the weather | The Impact of Weather on Influenza and Pneumonia Mortality in New York City, 1975–2002: A Retrospective Study. The substantial winter influenza peak in temperate climates has lead to the hypothesis that cold and/or dry air is a causal factor in influenza variability. We examined the relationship between cold and/or dry... | [
"Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression. The mitochondrial protein repertoire varies depending on the cellular state. Protein component modifications caused by mitochondrial DNA (mtDNA) depletion are related to a wide range of human diseases; however, little is know... | 2 | s5zr6tvk | [
"9egy68c0",
"4cjlolp6",
"7o6htufh",
"upjhmfca"
] | biomedical_literature_retrieval | scientific |
029aa92f64f5c4d09305738c4805f266 | mteb/scifact | Activation of the Rac1 homolog CED-10 kills viable cells in SRGP-1 mutant Caenorhabditis elegans. | Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans. Multicellular animals rapidly clear dying cells from their bodies. Many of the pathways that mediate this cell removal are conserved through evolution. Here, we identify srgp-1 as a negative regulator of cell clearance... | [
"Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses. For studying the function of specific neurons in their native circuitry, it is desired to precisely control their activity. This often requires dissection to allow accurate electrical stimulatio... | 71 | 1127562 | [
"7036529",
"11535539",
"5409905",
"25263810"
] | scientific_claim_retrieval | scientific |
24cb9d39bf45b51dd294a2dc330a1152 | mteb/trec-covid | what are the health outcomes for children who contract COVID-19? | Clinical and Epidemiological Characteristics of Pandemic Influenza A/(H1N1) in Hospitalized Pediatric Patients at a University Hospital, Istanbul, Turkey. Background: The aim of this study was to describe the clinical and epidemiological characteristics of pandemic influenza in hospitalized children. Methods: A total o... | [
"What is the diagnostic accuracy of single nerve conduction studies and muscle ultrasound to identify critical illness polyneuromyopathy: a prospective cohort study. BACKGROUND: Critical illness polyneuromyopathy (CIPNM) is a major cause of weakness in intensive care unit (ICU) patients, but current diagnostic test... | 47 | 86j0lyrw | [
"xtehuzt8",
"j7w5uee2",
"nkr9g0cu",
"qvevfimk"
] | biomedical_literature_retrieval | scientific |
5676f2bf341e3a1f56801b0ddf7b657f | mteb/scifact | Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK. | Tuberculosis mortality in England and Wales during 1982-1992: its association with poverty, ethnicity and AIDS.. This paper seeks to establish the strength of association between contemporary tuberculosis (TB) in England and Wales and several potential aetiological factors. It presents an ecological analysis of standar... | [
"Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care.. OBJECTIVES To investigate incidence, mortality and case survival trends for cancer of unknown primary site (CUP) and consider clinical implications. METHOD Sou... | 1327 | 22194407 | [
"20610390",
"2097256",
"22963769",
"13900610"
] | scientific_claim_retrieval | scientific |
4b9405350487daad5eea0c8f393a2942 | mteb/scifact | Microglia are an innate immune cell type of the peripheral nervous system. | Sublime Microglia: Expanding Roles for the Guardians of the CNS. Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or pathology, emerging lines of evidence indicate that microglia sculpt the s... | [
"Memory CD4+ T cells induce innate responses independently of pathogen. Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory respons... | 790 | 15493354 | [
"19005293",
"7820043",
"5476778",
"20960682"
] | scientific_claim_retrieval | scientific |
a214b26e023511a59d53aa59375d276f | mteb/scifact | Bariatric surgery leads to positive outcomes in mental health. | Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis.. IMPORTANCE Bariatric surgery is associated with sustained weight loss and improved physical health status for severely obese individuals. Mental health conditions may be common among patients seeking bariatric surgery; h... | [
"Psychological Outcome 4 Years after Restrictive Bariatric Surgery. Extreme obesity is associated with severe psychiatric and somatic comorbidity and impairment of psychosocial functioning. Bariatric surgery is the most effective treatment not only with regard to weight loss but also with obesity-associated illness... | 167 | 18872233 | [
"43220289",
"31612088",
"19071857",
"24988745"
] | scientific_claim_retrieval | scientific |
e185ece9767b17215c299a561388d786 | mteb/trec-covid | what type of hand sanitizer is needed to destroy Covid-19? | Review of global sanitation development. The implementation of the United Nations (UN) Millennium Development Goals (MDGs) and Sustainable Development Goals (SDGs) has resulted in an increased focus on developing innovative, sustainable sanitation techniques to address the demand for adequate and equitable sanitation i... | [
"Airspace-Occupying Diseases. Diseases of the air space of the lung share many common findings and presentation that it makes more sense to be grouped together in a differential diagnosis. The common imaging finding is usually as a lung infiltrate or consolidation of some type of distribution or another. Trying to ... | 19 | 8plv9q8b | [
"1ses23oz",
"vmcy38wt",
"mmd8ru3r",
"aet9nitv"
] | biomedical_literature_retrieval | scientific |
5660f49e5dc687e7d00b05f006b3353a | mteb/scifact | Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells. | Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells.. In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated... | [
"Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. The transfer of somatic cell nuclei into oocytes can give rise to pluripotent stem cells that are consistently equivalent to embryonic stem cells, holding promise for autologous cell replacement therapy. Although m... | 281 | 4632921 | [
"4457834",
"4392608",
"751192",
"42662816"
] | scientific_claim_retrieval | scientific |
b1dee8184517cc29b70479c01cc2bf00 | mteb/scifact | ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis. | Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1. Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. T... | [
"Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population. INTRODUCTION Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways and their negative regulators play a pivotal ro... | 366 | 13956305 | [
"2647374",
"11615242",
"17088791",
"263364"
] | scientific_claim_retrieval | scientific |
b83f23db83bed3c17166b7fa3650555b | mteb/scifact | eRNAs influence is linked to senescence, aging, and carcinogenesis. | eRNAs are required for p53-dependent enhancer activity and gene transcription.. Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using genome-wide chromatin-binding profiles, we describe bi... | [
"The intersection between aging and cardiovascular disease.. The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to do so in the next 20 years. Within this age group, cardiovascular disease will remain the leadin... | 1387 | 9669099 | [
"16233471",
"31293581",
"3230557",
"2547636"
] | scientific_claim_retrieval | scientific |
804adfaa1d9505294466ce46c210c17e | mteb/scifact | Long - range chromatin interactions regulate transcription. | Enhancer Evolution across 20 Mammalian Species. The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian specie... | [
"Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation. Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped l... | 704 | 14658685 | [
"18276599",
"5935987",
"5519177",
"9669099"
] | scientific_claim_retrieval | scientific |
24216e2b0e48cb4f4e1c4ca8390c333c | mteb/scifact | MICAL redox enzymes regulate actin dynamics in many cell types. | Drosophila MICAL regulates myofilament organization and synaptic structure. The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abnormally structured neuromuscular junctions (NMJs), we discov... | [
"Mical links semaphorins to F-actin disassembly. How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studied for their effects on cell movement, navigation, an... | 737 | 16562534 | [
"4417558",
"3506723",
"6784372",
"27134527"
] | scientific_claim_retrieval | scientific |
8856efdf444da4bfb10b794d811dbe70 | mteb/scifact | Alirocumab treatment reduces apo(a) fractional clearance rate. | Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans. BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have ... | [
"Integration of antiretroviral therapy with tuberculosis treatment.. BACKGROUND We previously reported that integrating antiretroviral therapy (ART) with tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during tuberculosis treatment remains unresolved. METHODS We conducted a t... | 98 | 6540064 | [
"7111021",
"20287253",
"40343416",
"45401535"
] | scientific_claim_retrieval | scientific |
2ac70ea119016c5dd67bc6803d392c57 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | A pilot study on primary cultures of human respiratory tract epithelial cells to predict patients’ responses to H7N9 infection. Avian influenza A(H7N9) virus infections frequently lead to acute respiratory distress syndrome and death in humans. We aimed to investigate whether primary cultures of human respiratory tract... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | 7xauocti | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
f87acfdbb193ecb05d7e82411656f4a9 | mteb/scifact | Amitriptyline is an effective treatment for chronic tension-type headaches. | Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications.. The tricyclic antidepressant, amitriptyline, is an effective drug for the treatment of chronic tension-type headache and for other chronic pain syndromes, but it is also effective in the prophylaxis of an episod... | [
"Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT).. Leukemia in donor cells (donor cell leukemia; DCL) has been reported as a rare but severe complication of allogeneic stem cell transplantation (SCT). Howev... | 108 | 22995579 | [
"11344428",
"3308636",
"44030361",
"24510595"
] | scientific_claim_retrieval | scientific |
f24e807e48313cdd33e7b032b622684e | mteb/scifact | M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes. | Human Monocytes Engage an Alternative Inflammasome Pathway.. Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this consti... | [
"Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma. Nicotinamide (Nam) phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in mammalian NAD synthesis, catalyzing nicotinamide mononucleotide (NMN) formation from Nam and 5-phosphoribosyl ... | 732 | 34469966 | [
"7116734",
"37641175",
"22705234",
"9814332"
] | scientific_claim_retrieval | scientific |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.