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29cf8c94ac19ec5d5b366d1427f0c6da | mteb/scifact | In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma. | Regulation of in situ to invasive breast carcinoma transition.. The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model o... | [
"Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model.. To gain insights into the possible role of oestrogen receptor (ER) beta in breast carcinogenesis, immunohistochemical analysis of ER beta was performed on 512... | 571 | 20333864 | [
"24249915",
"12762485",
"6807122",
"8963413"
] | scientific_claim_retrieval | scientific |
498ed74549f08672970d95b2b3ef7a20 | mteb/scifact | HAND2 methylation is a key step in early endometrial carcinogenesis. | Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development. BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumula... | [
"Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization.. Altered DNA methylation occurs ubiquitously in human cancer from the earliest measurable stages. A cogent approach to understanding the mechanism and timing of altered DNA methylation is to analyze it in the conte... | 488 | 1780819 | [
"11359243",
"20456030",
"6936141",
"6121668"
] | scientific_claim_retrieval | scientific |
07a221c23ad7a1a97b0c12298f69939a | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Immunity to infection | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | o7mfgehj | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
4f0d8e3aa9dbf8a4134ff06321ac1789 | mteb/trec-covid | what are the transmission routes of coronavirus? | Effects of Surface Material, Ventilation, and Human Behavior on Indirect Contact Transmission Risk of Respiratory Infection. Infectious particles can be deposited on surfaces. Susceptible persons who contacted these contaminated surfaces may transfer the pathogens to their mucous membranes via hands, leading to a risk ... | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | o1tjh69q | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
72a0c6cde7c715d666923f6e1c278ff9 | mteb/trec-covid | what are the transmission routes of coronavirus? | Microbial Contamination in Airplane Cabins:Health Effects and Remediation. Microorganisms that affect human health are found in all indoor environments, including cabins of commercial aircraft. Those that arise from human sources can be transmitted by direct contact, droplets, or the airborne route. Infections from hum... | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | cb9mheqh | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
81a38b70e7ca4ab7cc8eaa76e17fa245 | mteb/trec-covid | Does Vitamin D impact COVID-19 prevention and treatment? | Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005–2016 NHANES. A well-functioning immune system is essential for human health and well-being. Micronutrients such as vitamins A, C, D, E, and zinc have several functions throughout the immune system, yet inadequate nutrient intakes are pervasive in the... | [
"Impact of formaldehyde addition to spray-dried plasma on functional parameters and animal performance(). Experimental objectives of this study were to determine effects of formaldehyde treatment on the chemical composition of spray-dried plasma (SDP) and to test the hypothesis that growth performance of pigs fed f... | 42 | bd10ce5d | [
"e8ahfzum",
"8it9kxyo",
"mdkuf5bd",
"zhw8vh3e"
] | biomedical_literature_retrieval | scientific |
dba26e3f7c5d7ccdc15c8ff48336f759 | mteb/scifact | Interleukin-18 plays an important role in the pathogenesis of atherosclerosis. | Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms. Interruption of IL18 action reduces atherosclerosis in mice. Here, we show that absence of the IL18 receptor (IL18r... | [
"Usefulness of high mobility group box 1 protein as a plasma biomarker in patient with peripheral artery disease.. Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, bu... | 653 | 24384587 | [
"21372171",
"2130391",
"15889329",
"35543846"
] | scientific_claim_retrieval | scientific |
755cf0e9eba0c06fdebb83e650dee194 | mteb/scifact | Approximately 250,000 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom. | HTLV-I/II associated disease in England and Wales, 1993-7: retrospective review of serology requests.. Apart from HIV two exogenous retroviruses (human T cell leukaemia viruses type I (HTLV-I) and type II (HTLV-II)) infect humans. HTLV-I infection is endemic in Japan, the Caribbean, Africa, and Melanesia and is found a... | [
"Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells.. Wild-type p53 has recently been shown to repress transcription from several cellular and viral promoters. Since p53 mutations are the most frequently reported genetic defects in human cancers, it becomes important to stu... | 126 | 24512064 | [
"23985464",
"27602752",
"42065070",
"5867846"
] | scientific_claim_retrieval | scientific |
84407617b5f57d2421a568cce7aacf6a | mteb/scifact | Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML) | Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.. Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing n... | [
"Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia.. Pancytopenia is a major cause of morbidity in acute myeloid leukemia (AML), yet its cause is unclear. Normal osteoblastic cells have been shown to support hematopoiesis. To define the effects of leukemia on osteoblastic cel... | 182 | 11369420 | [
"10795340",
"6374918",
"25148216",
"19510470"
] | scientific_claim_retrieval | scientific |
38d1c2d65b6ffafc440d47e27d550d7e | mteb/trec-covid | What are the observed mutations in the SARS-CoV-2 genome and how often do the mutations occur? | Virus Evolution in the Face of the Host Response. Microbial infections are highly dynamic. Viruses have evolved two main strategies against the host response: interaction or evasion. Interaction is typical of complex DNA viruses. Their genomes encode a number of proteins that exert modulatory functions that alter the i... | [
"An evaluation of Comparative Genome Sequencing (CGS) by comparing two previously-sequenced bacterial genomes. BACKGROUND: With the development of new technology, it has recently become practical to resequence the genome of a bacterium after experimental manipulation. It is critical though to know the accuracy of t... | 40 | d8qmp725 | [
"sabz03c0",
"vhlshqbc",
"b426t461",
"pr8za61l"
] | biomedical_literature_retrieval | scientific |
3087143ae7251bce6f310b761f647a2e | mteb/scifact | B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2. | Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.. Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC... | [
"PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization.. Cells of the osteoblast lineage provide critical support for B lymphopoiesis in the bone marrow (BM). Parathyroid hormone (PTH) signaling in osteoblastic cells through its receptor (PPR) is an important regulator of ... | 152 | 15488881 | [
"38899659",
"364522",
"15593561",
"6767271"
] | scientific_claim_retrieval | scientific |
168bcfcd88545a060b3fd7181eb29857 | mteb/scifact | For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth. | Changes in the prevalence of cerebral palsy for children born very prematurely within a population-based program over 30 years.. CONTEXT Although cerebral palsy (CP) among extremely premature infants has been reported as a major morbidity outcome, there are difficulties comparing published CP rates from many sites over... | [
"Neurodevelopmental Outcome After a Single Course of Antenatal Steroids in Children Born Preterm: A Systematic Review and Meta-analysis.. OBJECTIVE To systematically review and integrate data on the neurodevelopmental outcome of children after administration of a single course of antenatal corticosteroids for threa... | 425 | 33257464 | [
"20645335",
"25742130",
"5132358",
"980196"
] | scientific_claim_retrieval | scientific |
067ff2f9a8c4b6841e502aecb8c8beb6 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Current Practices for Infection Prevention in the Hospital Settings. The principles and practices aimed at prevention and control of hospital-acquired infections are directed at various links in the chain of transmission. They include the following: (1) to contain or eliminate the reservoirs of agents and/or to curtail... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | mtpbzgr9 | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
8d6f28872deef22977deb666b00dee59 | mteb/scifact | Traditional reviews are biased in their interpretations. | Systematic reviews from astronomy to zoology: myths and misconceptions.. Systematic literature reviews are widely used as an aid to evidence based decision making. For example, reviews of randomised controlled trials are regularly used to answer questions about the effectiveness of healthcare interventions. The high pr... | [
"CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals.. Hyperactivation of T cells, particularly of CD8(+) T cells, is a hallmark of chronic HIV 1 (HIV-1) infection. Little is known about the antigenic specificities and the mechanisms by which HIV-1 causes activation of CD8(+) T c... | 1310 | 8042158 | [
"35987381",
"7011850",
"6323196",
"12801438"
] | scientific_claim_retrieval | scientific |
c9071d01791282537e60b6b2951cfb3b | mteb/scifact | MEK inhibitors are effective treatments in RAS-driven mouse models of cancer. | Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers. Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-alpha catalytic subunit (encoded by PIK3CA). They are most frequently observed in two hotspots: the helical domain ... | [
"Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth. Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell mig... | 734 | 4961038 | [
"67045088",
"13952658",
"4820792",
"22482820"
] | scientific_claim_retrieval | scientific |
031bc204e9c3aebfc36bd0986c1e7f55 | mteb/scifact | Rhythmic expression of Cry1 translates directly into a circadian regulation of cAMP signaling in gluconeogenesis. | Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis. During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated ... | [
"MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways. The mechanisms underlying the development of aging-induced muscle atrophy are unclear. By microRNA array and individual qPCR analyses, we found significant up-regulation of miR-29 in muscles of aged rodents vs. results in ... | 1044 | 22500262 | [
"4653837",
"26099680",
"14367469",
"23509593"
] | scientific_claim_retrieval | scientific |
f8ac9e5b52ce4e209cd3b8a784242a5d | mteb/scifact | Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population. | Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age. Importance Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential. Objective To determine the associations between biomarkers of ov... | [
"Diminished performance on neuropsychological testing in late life depression is correlated with microstructural white matter abnormalities.. BACKGROUND Traditional T2 weighted MR imaging results are non-specific for the extent of underlying white matter structural abnormalities present in late life depression (LLD... | 349 | 13497630 | [
"1412089",
"12513972",
"2787558",
"456304"
] | scientific_claim_retrieval | scientific |
f06eed192e01008af6a33956143683ad | mteb/scifact | Deltex interacts with eIF3. There is no known interaction between Deltex and elF3 | The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation. Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secret... | [
"Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma.. BACKGROUND Although inhaled corticosteroids have an established role in the treatment of asthma, studies have tended to concentrate on non-smokers and little is known about the possible effect of cigarette smoking on the efficacy o... | 331 | 9505448 | [
"20611846",
"5641851",
"12794099",
"24384587"
] | scientific_claim_retrieval | scientific |
458032ab4e06295c2e29abe7853d3280 | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin-angiotensin system in inflammation. Traditionally viewed as important in the regulation of blood pressure, the renin-angiotensin system - and specifically the angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-AT(1 )receptor ... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | t7rxmzvi | [
"mx4t6s6n",
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"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
2cd7a3d917049fdf2f7513341cca5ebf | mteb/scifact | Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae. | Sir2-Independent Life Span Extension by Calorie Restriction in Yeast. Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathw... | [
"Yeast sirtuins and the regulation of aging.. The sirtuins are a phylogenetically conserved family of NAD(+) -dependent protein deacetylases that consume one molecule of NAD(+) for every deacetylated lysine side chain. Their requirement for NAD(+) potentially makes them prone to regulation by fluctuations in NAD(+)... | 472 | 7185591 | [
"1754001",
"4463811",
"9310407",
"323335"
] | scientific_claim_retrieval | scientific |
fea8b9d9c91a262654b00fb0ed344edb | mteb/scifact | The microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) is partially responsible for the disassembly of adhesion sites. | CLASPs link focal adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover. Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs assemble near the leading edge... | [
"Lysyl oxidase is essential for hypoxia-induced metastasis. Metastasis is a multistep process responsible for most cancer deaths, and it can be influenced by both the immediate microenvironment (cell–cell or cell–matrix interactions) and the extended tumour microenvironment (for example vascularization). Hypoxia (l... | 1229 | 1676568 | [
"4429932",
"6767271",
"43890638",
"12658073"
] | scientific_claim_retrieval | scientific |
f2a6ce317c2952b7010a0a9d9dd2d906 | mteb/scifact | The composition of myosin-II isoform switches from the A isoform to the B isoform during hematopoietic differentiation. | Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells.. Self-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by nonmuscle myosin-II (MII) forces and matrix mechanics. Here, mass spectrometry-ca... | [
"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation.. High-throughput mRNA sequencing (RNA-Seq) promises simultaneous transcript discovery and abundance estimation. However, this would require algorithms that are not restricted by prio... | 1206 | 18909530 | [
"27061085",
"3868322",
"344240",
"10359591"
] | scientific_claim_retrieval | scientific |
9e2718f01a6d0e5ace9d611afe4f2c31 | mteb/scifact | Roughly 55% of women with chronic pelvic pain have no underlying pathology. | Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial.. CONTEXT Chronic pelvic pain is a common condition with a major effect on health-related quality of life, work productivity, and health care use. Operative interruption of nerve trunks in the uterosacral ligament... | [
"Angina with \"normal\" coronary arteries: sex differences in outcomes.. BACKGROUND Several studies have demonstrated that women with nonobstructive coronary disease have a high rate of subsequent investigations, rehospitalizations for recurrent chest pain, and repeat coronary angiography. The sex specificity of th... | 1058 | 13027590 | [
"12561083",
"32534305",
"9822397",
"43226130"
] | scientific_claim_retrieval | scientific |
6208617ac8290aa30fb949bd8b6027f3 | mteb/trec-covid | are cardiac complications likely in patients with COVID-19? | Clinical aspects of virus/immune myocarditis. Although a cause-and-effect relationship between viral infection and myocarditis remains inferential, two distinct clinical syndromes can be identified. During the early viral phase, the cardiac manifestations emerge while the symptoms of active viral infection are also pre... | [
"Demographic profile and outcome analysis of a tertiary level pediatric intensive care unit. Objective : To study the profile and outcome of children admitted to a tertiary level pediatric intensive care unit (PICU) in India.Methods : Prospective study of patient demographics, PRISM III scores, diagnoses, treatment... | 22 | 0jp0z5kp | [
"18dxcn41",
"zhw8vh3e",
"1ddfywfa",
"5yt1cgkx"
] | biomedical_literature_retrieval | scientific |
61ea1c58fc5644a4b708206b4a6b3519 | mteb/scifact | Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings. | Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. BACKGROUND The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides a... | [
"Adapting the WHO package of essential noncommunicable disease interventions, Samoa. Problem Samoa has been struggling to address the burden of noncommunicable diseases at the health system, community and individual levels. Approach The World Health Organization (WHO) package of essential noncommunicable disease in... | 383 | 13770184 | [
"51972698",
"12428497",
"24721347",
"32328114"
] | scientific_claim_retrieval | scientific |
589bd8250df42c487ddf0c67bcc89d38 | mteb/scifact | Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue. | Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. However, the mechanisms behind these effects are unclear. Here we show that nicotin... | [
"Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.. Sirt1 is a NAD(+)-dependent class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neuronal Sirt1 activity p... | 1025 | 32408470 | [
"2481032",
"970012",
"1840993",
"40232172"
] | scientific_claim_retrieval | scientific |
0876c0fa507196dd3a933cc18308f6e8 | mteb/trec-covid | what evidence is there for the value of hydroxychloroquine in treating Covid-19? | Use of chloroquine in viral diseases | [
"Urgent intubation without neuromuscular blocking agents and the risk of tracheostomy. Neuromuscular blocking agents play a significant role in improving the success rate for urgent intubation, although there is limited evidence about the effect on subsequent outcomes, such as the incidence of tracheostomy. In this... | 28 | p4s7x79d | [
"f4rn9m95",
"2bau2dn8",
"d3d1n9qa",
"72s8wpla"
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1d4b263f44383dad3e6f0ae1a239e0fc | mteb/scifact | Adult tissue-resident macrophages are seeded before birth. | Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.. Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manipulati... | [
"A lineage of myeloid cells independent of Myb and hematopoietic stem cells.. Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive... | 85 | 7521113 | [
"22973574",
"12827098",
"5511240",
"9629682"
] | scientific_claim_retrieval | scientific |
d0899472dc25dfed813b50806d04aab4 | mteb/scifact | The generation of reactive oxygen species by activated oncogenes contributes to the increased genomic instability of leukaemia cells. | BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.. The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic... | [
"Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?. Myelodysplastic syndromes (MDS) comprise a heterogeneous group of disorders characterized by ineffective hematopoiesis, with an increased propensity to develop acute myelogenous leuke... | 1220 | 13023410 | [
"5765455",
"4391121",
"21439640",
"1941721"
] | scientific_claim_retrieval | scientific |
6dfae1884fe3bd3c3fa35d9070efe444 | mteb/scifact | Activated Cdk5 phosphorylates the ATM protein in response to DNA damage. | Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death. The phosphatidylinositol-3-kinase-like kinase ATM (ataxia-telangiectasia mutated) has a central role in coordinating DNA damage responses, including cell-cycle checkpoint control, DNA repair and apoptosis. Mutations of ATM cause ... | [
"PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening.. The alternative lengthening of telomeres (ALT) mechanism allows cancer cells to escape senescence and apoptosis in the absence of active telomerase. A characteristic feature of this pathway is ... | 67 | 21295300 | [
"213017",
"30122260",
"12909503",
"30353437"
] | scientific_claim_retrieval | scientific |
8c638bcf0098d37d560bfbe765c1b1c9 | mteb/scifact | A deficiency of vitamin B12 decreases blood levels of homocysteine. | Randomized trial of folic acid supplementation and serum homocysteine levels.. BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (relevan... | [
"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial.. CONTEXT High plasma homocysteine levels are a risk factor for mortality and vascular disease in observational studies of patients with chronic kidney dis... | 35 | 11705328 | [
"33409100",
"3034412",
"18557974",
"7116734"
] | scientific_claim_retrieval | scientific |
5ea7a923d288e08dba797c33a5632d79 | mteb/scifact | Migraine with aura is associated with ischemic stroke. | Migraine and cardiovascular disease: systematic review and meta-analysis.. OBJECTIVE To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular disease. DESIGN Systematic review and meta-analysis. DATA SOURCES Electronic databases (P... | [
"Cardiovascular risk factors and migraine: the GEM population-based study.. BACKGROUND Migraine, particularly with aura, is a risk factor for early-onset ischemic stroke. The underlying mechanisms are unknown, but may in part be due to migraineurs having an increased risk profile for cardiovascular disease. In this... | 791 | 15984735 | [
"23785605",
"8672737",
"23627419",
"39390206"
] | scientific_claim_retrieval | scientific |
7f3e8c5796010de7be6251032b50ff0f | mteb/trec-covid | how does the coronavirus respond to changes in the weather | Identification of climate factors related to human infection with avian influenza A H7N9 and H5N1 viruses in China. Human influenza infections display a strongly seasonal pattern. However, whether H7N9 and H5N1 infections correlate with climate factors has not been examined. Here, we analyzed 350 cases of H7N9 infectio... | [
"Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression. The mitochondrial protein repertoire varies depending on the cellular state. Protein component modifications caused by mitochondrial DNA (mtDNA) depletion are related to a wide range of human diseases; however, little is know... | 2 | ulq1xqma | [
"9egy68c0",
"4cjlolp6",
"7o6htufh",
"upjhmfca"
] | biomedical_literature_retrieval | scientific |
c2de7cf2b0f70b433694e9a9702ce287 | mteb/trec-covid | how long can the coronavirus live outside the body | Survival of Coronaviruses in Water and Wastewater. The advent of severe acute respiratory syndrome and its potential environmental transmission indicates the need for more information on the survival of coronavirus in water and wastewater. The survival of representative coronaviruses, feline infectious peritonitis viru... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | 0y8lfjkx | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
6186db03820dbc64a81acaa47ec8d0b4 | mteb/scifact | Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut. | Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-threatening bacteremia. Here we show that simian immunodefic... | [
"Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.. Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound ... | 332 | 29023309 | [
"8300657",
"13398997",
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"22705234"
] | scientific_claim_retrieval | scientific |
438d42a78e1c36719c2b0ae09a9398f4 | mteb/scifact | JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity. | JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation. Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family, the cellular activity of JMJD6 is still not clearly defined and its biological function... | [
"The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription.. Although most cytokines are studied for biological effects after engagement of their specific cell surface membrane receptors, increasing evidence suggests that some function in the nucleus. In the present study, the prec... | 661 | 37204802 | [
"44935041",
"15176526",
"42865134",
"16056410"
] | scientific_claim_retrieval | scientific |
6c253231e5da62e26f0812fc056689f4 | mteb/scifact | In British Men, haplogroup I increases risk of cardiovascular disease by 50%. | Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in ... | [
"The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.. OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its... | 564 | 2867345 | [
"8780599",
"12770738",
"6176498",
"11630388"
] | scientific_claim_retrieval | scientific |
de20ca8653210531937279e96783c31d | mteb/scifact | 10% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months. | Sudden infant death syndrome.. Despite declines in prevalence during the past two decades, sudden infant death syndrome (SIDS) continues to be the leading cause of death for infants aged between 1 month and 1 year in developed countries. Behavioural risk factors identified in epidemiological studies include prone and s... | [
"Research Priorities in Sudden Unexpected Infant Death: An International Consensus.. Despite the success of safe sleep campaigns and the progress in understanding risk factors, the rate of reduction in the cases of sudden infant death syndrome has now slowed and it remains a leading cause of postneonatal mortality ... | 6 | 2613775 | [
"21050357",
"3944632",
"15692098",
"23117378"
] | scientific_claim_retrieval | scientific |
1d11c308515c4317f96f805b78a62bb6 | mteb/scifact | Pyridostatin deregulates G2/M progression. | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand ... | [
"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.. DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular responses that enable the cell either to eliminate or cope with the ... | 992 | 16472469 | [
"38131471",
"7165938",
"5273056",
"30492966"
] | scientific_claim_retrieval | scientific |
73b4323d9dccdd1083a91a56353a817d | mteb/scifact | Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR). | Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.. DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functi... | [
"Deregulated DNA polymerase β strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities. DNA polymerase β (Pol β) is an error-prone enzyme which has been found to be overexpressed in several human tumors. By using a couple of recombinant CHO cells differing only from the exogenous expression ... | 774 | 32275758 | [
"11569583",
"3173489",
"18987782",
"31293581"
] | scientific_claim_retrieval | scientific |
72dbf0d1cb45dcb6c60031a93836ea35 | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | DetectiV: visualization, normalization and significance testing for pathogen-detection microarray data. DNA microarrays offer the possibility of testing for the presence of thousands of micro-organisms in a single experiment. However, there is a lack of reliable bioinformatics tools for the analysis of such data. We ha... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | rzzsmuoc | [
"6324190r",
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56a879b278f4e36c82733334b09fa009 | mteb/scifact | Adult tissue-resident macrophages possess a self-renewing capacity. | Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.. Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manipulati... | [
"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.. Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes. Using parabiosis... | 88 | 7521113 | [
"12827098",
"20186814",
"36637129",
"4381486"
] | scientific_claim_retrieval | scientific |
b45278f3e7fba1f1706312cea6b4745f | mteb/trec-covid | how long can the coronavirus live outside the body | Airborne/Droplet Infection Isolation. Airborne/droplet infection is caused by infected agents in the air around a person. Microbial pathogenic agents that are mainly transmitted airborne are aerosols, re-aerosols, microbe-carrying particles, huge amounts of bacteria-carrying airborne skin cells, dust, droplets and drop... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | 1x0oqzq0 | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
7320f088f652abf5c90b337e70569fd0 | mteb/scifact | Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue. | Inflammatory signaling in human Tuberculosis granulomas is spatially organized. Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects w... | [
"Local neuroinflammation and the progression of Alzheimer’s disease. Postmortem immunohistochemical studies have revealed a state of chronic inflammation limited to lesioned areas of brain in Alzheimer’s disease. Some key actors in this inflammation are activated microglia (brain macrophages), proteins of the class... | 1328 | 3475317 | [
"17438862",
"24707550",
"28392393",
"15521377"
] | scientific_claim_retrieval | scientific |
2ae94940f6c42bd87a5927f989d56ebc | mteb/scifact | Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months. | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.. CONTEXT Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. OBJECTIVE To determine whether physical a... | [
"Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.. BACKGROUND AN1792 (beta-amyloid [Abeta]1-42) immunization reduces Abeta plaque burden and preserves cognitive function in APP transgenic mice. The authors report the results of a phase IIa immunotherapy trial of AN1792(QS... | 621 | 1642727 | [
"46565020",
"15678772",
"21323758",
"15041758"
] | scientific_claim_retrieval | scientific |
173829613ebb61942d3b7a9f357d5d33 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Use of Toll-Like Receptor 3 Agonists Against Respiratory Viral Infections. Respiratory RNA viruses are constantly evolving, thus requiring development of additional prophylactic and therapeutic strategies. Harnessing the innate immune system to non-specifically respond to viral infection has the advantage of being able... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | of9t5i10 | [
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] | biomedical_literature_retrieval | scientific |
deb14a66c446ad83087dfb20688017b1 | mteb/scifact | There is no increased risk of hypospadias with clomiphene. | Use of clomifene during early pregnancy and risk of hypospadias: population based case-control study.. Clomifene is widely used for inducing ovulation.1 It is structurally related to diethylstilbestrol, which has been linked to vaginal and cervical clear cell adenocarcinoma in women exposed in utero. The adverse effect... | [
"Metabolic syndrome as a risk factor for diabetes.. The metabolic syndrome was initially described as an insulin-resistance syndrome characterized by the clustering of metabolic traits such as high triglycerides, low high-density lipoprotein cholesterol, high blood pressure, abdominal obesity and different degrees ... | 1293 | 43329366 | [
"27449472",
"23013317",
"24341590",
"37619697"
] | scientific_claim_retrieval | scientific |
a29acd54d2d9e77eca5ae44aabb54974 | mteb/scifact | Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane. | Dynamic Helix Interactions in Transmembrane Signaling. Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned from these examples. Such efforts suggest that some of the m... | [
"Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation. How membrane receptors initiate signal transduction upon ligand binding is a matter of intense scrutiny. The T cell receptor complex (TCR-CD3) is composed of TCR alpha/beta ligan... | 757 | 17123657 | [
"2714623",
"31107919",
"44640124",
"82665667"
] | scientific_claim_retrieval | scientific |
8f06546aec31f1b2724ac7f8f26c6f25 | mteb/scifact | Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells. | Human somatic cell nuclear transfer using adult cells.. Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of therapeutic contexts. However, successful SCNT with human cells has proved challenging to achieve, and thus far ha... | [
"Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. The transfer of somatic cell nuclei into oocytes can give rise to pluripotent stem cells that are consistently equivalent to embryonic stem cells, holding promise for autologous cell replacement therapy. Although m... | 866 | 37822406 | [
"4457834",
"4405194",
"3360421",
"4380451"
] | scientific_claim_retrieval | scientific |
d057f73863d3c89fd08c484d0c5d2956 | mteb/scifact | Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function. | Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.. To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EB... | [
"CHD4 Is a RanGTP-Dependent MAP that Stabilizes Microtubules and Regulates Bipolar Spindle Formation. BACKGROUND Production of the GTP-bound form of the Ran GTPase (RanGTP) around chromosomes induces spindle assembly by activating nuclear localization signal (NLS)-containing proteins. Several NLS proteins have been... | 280 | 25001628 | [
"1684489",
"40721190",
"5573975",
"3174305"
] | scientific_claim_retrieval | scientific |
06fdacea7e3d1e854272f3d025c90896 | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Prior infection of pigs with a recent human H3N2 influenza virus confers minimal cross‐protection against a European swine H3N2 virus. BACKGROUND: H3N2 influenza viruses circulating in humans and European pigs originate from the pandemic A/Hong Kong/68 virus. Because of slower antigenic drift in swine, the antigenic di... | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | zoud7w1y | [
"9807pgmy",
"1kwb0v71",
"5zuij5i3",
"xmjzgqq7"
] | biomedical_literature_retrieval | scientific |
3e6d7475d1934868bdc11f55e4232672 | mteb/scifact | Systemic immunosuppressive (IS) therapy does not enhance the chance of cancer mortality in patients with inflammatory eye disease (IED) | Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study.. CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective ... | [
"Antineutrophil cytoplasmic antibodies (ANCA).. Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis. Using indirect immunofluorescence on ethanol-fixed neutrophils, two major fluoroscopic patterns can be recognised: a diffuse cytoplasmic staining ... | 1125 | 21009874 | [
"6251620",
"4911006",
"13231899",
"3878434"
] | scientific_claim_retrieval | scientific |
bedc4dabb7fb6ef4bbe2020a89937573 | mteb/scifact | Incidence of sepsis has fallen substantially from 2009 to 2014. | Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected b... | [
"Prolonged effect of calcium supplementation on risk of colorectal adenomas in a randomized trial.. BACKGROUND Calcium supplementation has been shown to decrease the risk of recurrence of colorectal adenomas in randomized trials. However, the duration of this protective effect after cessation of active supplementat... | 595 | 4824840 | [
"46485368",
"25121903",
"18084826",
"12428137"
] | scientific_claim_retrieval | scientific |
06826e0ef23691a5a81ea793ff92a044 | mteb/scifact | Aged patients are more susceptible to ischaemia/reperfusion injury. | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems. We ... | [
"Characterisation of antibiotic prescriptions for acute respiratory tract infections in Danish general practice: a retrospective registry based cohort study. Inappropriate use of antibiotics is contributing to the increasing rates of antimicrobial resistance. Several Danish guidelines on antibiotic prescribing for ... | 92 | 1084345 | [
"3272084",
"25816994",
"38376189",
"34121231"
] | scientific_claim_retrieval | scientific |
e2eeffbfd0fe68f8e72adb7be51ab863 | mteb/trec-covid | how long can the coronavirus live outside the body | Transmission of Influenza A in a Student Office Based on Realistic Person-to-Person Contact and Surface Touch Behaviour. Influenza A viruses result in the deaths of hundreds of thousands of individuals worldwide each year. In this study, influenza A transmission in a graduate student office is simulated via long-range ... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | 6yu02snn | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
ec4562bdcd9874180a67b0a40639a4e6 | mteb/scifact | Adult tissue-resident macrophages are seeded before birth. | Origin and functions of tissue macrophages.. Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its own co... | [
"A lineage of myeloid cells independent of Myb and hematopoietic stem cells.. Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive... | 85 | 22406695 | [
"22973574",
"12827098",
"5511240",
"9629682"
] | scientific_claim_retrieval | scientific |
de7b641374126ef4a47430a46a669a85 | mteb/scifact | DRD1 proteins enable Pol V transcription in vivo. | Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes. Nuclear transcription is not restricted to genes but occurs throughout the intergenic and noncoding space of eukaryotic genomes. The functional significance of this widespread noncoding transcri... | [
"AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs. AFF1 and AFF4 belong to the AFF (AF4/FMR2) family of proteins, which function as scaffolding proteins linking two different transcription elongation factors, positive elongation factor b (P-TEFb) and ELL1/2, in super elongation com... | 305 | 14797520 | [
"25022826",
"18447487",
"38131471",
"13072112"
] | scientific_claim_retrieval | scientific |
23b703e9e6ef334e7481360cc7a82fdb | mteb/scifact | The innate immune response struggles to remove small numbers of parasites. | Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number.. Immune clearance and resource limitation (via red blood cell depletion) shape the peaks and troughs of malaria parasitemia, which in turn affect disease severity and transmission. Quantitatively partitioning the ... | [
"Age-structured red blood cell susceptibility and the dynamics of malaria infections.. Malaria parasites and immune responses in an infected human interact on a dynamic landscape, in which a population of replicating parasites depletes a population of replenishing red blood cells (RBCs). These underlying dynamics r... | 1223 | 5289038 | [
"26474812",
"44562221",
"14853989",
"40323148"
] | scientific_claim_retrieval | scientific |
233a9bafb2e3a0a17a388288a8f19d77 | mteb/scifact | Beta-band coherence is diminished for visible stimuli over invisible stimuli. | Converging Intracranial Markers of Conscious Access. We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed in multiple cortical areas, most... | [
"Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease.. The rat kidney ablation and infarction (A/I) model of subtotal or 5/6th nephrectomy is the most commonly studied model of nondiabetic chronic kidney disease (CKD). The A/I kidney a... | 174 | 1710116 | [
"26025820",
"41493639",
"9159495",
"25597580"
] | scientific_claim_retrieval | scientific |
630fa7d67c66fbe53b153e818f8bb994 | mteb/scifact | Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth. | Maximal aerobic capacity in African-American and Caucasian prepubertal children.. The purpose of this study was to examine differences in resting, submaximal, and maximal (VO2max) oxygen consumption (VO2) in African-American (n = 44) and Caucasian (n = 31) prepubertal children aged 5-10 yr. Resting VO2 was measured via... | [
"Consumption of added sugars from liquid but not solid sources predicts impaired glucose homeostasis and insulin resistance among youth at risk of obesity.. Little is known about longitudinal associations between added sugar consumption (solid and liquid sources) and glucose-insulin homeostasis among youth. Caucasi... | 946 | 26112696 | [
"11201004",
"52865789",
"39390206",
"41976370"
] | scientific_claim_retrieval | scientific |
18c27f1b7f6f595b4243e39a67f7b403 | mteb/scifact | r-protein chaperones are found in complexes with their r-protein binding partners. | Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics. Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. ... | [
"Cell and molecular mechanisms of insulin-induced angiogenesis. Angiogenesis, the development of new blood vessel from pre-existing vessels, is a key process in the formation of the granulation tissue during wound healing. The appropriate development of new blood vessels, along with their subsequent maturation and ... | 1402 | 8126244 | [
"6673421",
"11603066",
"11420613",
"24917562"
] | scientific_claim_retrieval | scientific |
8f88f5b1d709a1ba91580162e1eaed55 | mteb/scifact | The NF-κB essential modulator gene prevents intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death. | NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions. Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD). IEC-... | [
"Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. De-regulation of the wingless and integration site growth factor (WNT) signaling pathway via mutations in APC and Axin, proteins that target β-catenin for destruction, have been linked to... | 1171 | 18956141 | [
"17648235",
"3504761",
"3748310",
"14362678"
] | scientific_claim_retrieval | scientific |
561279df84035bdd8d3a22e8d8bbcf0e | mteb/trec-covid | what are the health outcomes for children who contract COVID-19? | Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study. INTRODUCTION: Even in developed economies infectious diseases remain the most common cause of illness in early childhood. Our current understanding of the epidemiology of these infections is limited by reliance on data from ... | [
"What is the diagnostic accuracy of single nerve conduction studies and muscle ultrasound to identify critical illness polyneuromyopathy: a prospective cohort study. BACKGROUND: Critical illness polyneuromyopathy (CIPNM) is a major cause of weakness in intensive care unit (ICU) patients, but current diagnostic test... | 47 | 06e9lkwl | [
"xtehuzt8",
"j7w5uee2",
"nkr9g0cu",
"qvevfimk"
] | biomedical_literature_retrieval | scientific |
52284736610bb608253d391e5ba5f365 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Wearing face masks in public during the influenza season may reflect other positive hygiene practices in Japan. BACKGROUND: Although the wearing of face masks in public has not been recommended for preventing influenza, these devices are often worn in many Asian countries during the influenza season. In Japan, it is th... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | baxxcyji | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
99b9a75bf4317dc18e232095667ae548 | mteb/scifact | Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs). | MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been investigated to any extent. Here, we examine different exo... | [
"miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions.. BACKGROUND & AIMS Tumor cells survive hypoxic conditions by inducing autophagy. We investigated the roles of microRNAs (miRNAs) in regulating autophagy of hepatocellular carcinoma (HCC) cells under hypoxic... | 751 | 19800147 | [
"982650",
"654735",
"5377642",
"13070316"
] | scientific_claim_retrieval | scientific |
001202576dba16ad9b3ff01e46c7a52b | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Temporal Dynamics of Co-circulating Lineages of Porcine Reproductive and Respiratory Syndrome Virus. Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is the most important endemic pathogen in the U.S. swine industry. Despite control efforts involving improved biosecurity and different vaccination protocols, ... | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | 3e58229u | [
"9807pgmy",
"1kwb0v71",
"5zuij5i3",
"xmjzgqq7"
] | biomedical_literature_retrieval | scientific |
7b7cc74a611c427661b85ca9512a729e | mteb/scifact | COPI coatmer is involved in viral replication. | COPI Complex Is a Regulator of Lipid Homeostasis. Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin, adipocyte diff... | [
"Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement.. The HIV-1 protein Nef enhances viral pathogenicity and accelerates disease progression in vivo. Nef potentiates T cell activation by an unknown mechanism, probably by optimizing the intracellul... | 211 | 13794374 | [
"6936141",
"14376683",
"19356271",
"6820680"
] | scientific_claim_retrieval | scientific |
97a500208d9ca48c94f3941568afd9e5 | mteb/scifact | Medications to treat obesity do not have side effects. | Long term pharmacotherapy for obesity and overweight: updated meta-analysis.. OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of randomised trials. DATA SOURCES Medline, Embase, the Cochrane controlled trials register, the ... | [
"A comparison of letrozole to gonadotropins for ovulation induction, in subjects who failed to conceive with clomiphene citrate.. OBJECTIVE To compare pregnancy rates (PR) for letrozole and gonadotropins in individuals who failed to conceive with clomiphene citrate (CC). DESIGN Retrospective cohort study. SETTING U... | 765 | 7552215 | [
"22534357",
"6313547",
"583260",
"25761154"
] | scientific_claim_retrieval | scientific |
697e34741760fe817e4c4255e4fb0a21 | mteb/scifact | Prescribed exercise training improves quality of life. | Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial.. CONTEXT Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent. OBJECTIVE To test the effects of exercise training on health ... | [
"Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension.. BACKGROUND Pulmonary hypertension (PH) is associated with restricted physical capacity, limited quality of life, and a poor prognosis because of right heart failure. The present ... | 965 | 40817021 | [
"2820454",
"2028532",
"2774906",
"4164929"
] | scientific_claim_retrieval | scientific |
e4698ad4e0fad78eaeb911ec99f3b044 | mteb/scifact | Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits. | Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been describe... | [
"Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.. Plus-end tracking proteins, such as EB1 and the dynein/dynactin complex, regulate microtubule dynamics. These proteins are thought to stabilize microtubules by forming a plus-end complex at microtubule growing ends with ... | 612 | 9638032 | [
"21598000",
"37204802",
"23052989",
"25606339"
] | scientific_claim_retrieval | scientific |
0958e728f4d6248eab46730879083fa4 | mteb/scifact | miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription. | MicroRNAs can generate thresholds in target gene expression. MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow cytometry to monitor a target gene's ... | [
"Cocoa flavonols and procyanidins promote transforming growth factor-beta1 homeostasis in peripheral blood mononuclear cells.. Evidence suggests that certain flavan-3-ols and procyanidins (FP) can have a positive influence on cardiovascular health. It has been previously reported that FP isolated from cocoa can pot... | 1393 | 2000038 | [
"38712515",
"11557602",
"8856690",
"19358586"
] | scientific_claim_retrieval | scientific |
793d357d924d7b14d6afa35fa6761f5d | mteb/trec-covid | which SARS-CoV-2 proteins-human proteins interactions indicate potential for drug targets. Are there approved drugs that can be repurposed based on this information? | Drug repurposing strategies for COVID-19. COVID-19 has now been declared a pandemic and new treatments are urgently needed as we enter a phase beyond containment. Developing new drugs from scratch is a lengthy process, thus impractical to face the immediate global challenge. Drug repurposing is an emerging strategy whe... | [
"Single-Particle cryo-EM as a Pipeline for Obtaining Atomic Resolution Structures of Druggable Targets in Preclinical Structure-Based Drug Design. Single-particle cryo-electron microscopy (cryo-EM) and three-dimensional (3D) image processing have gained importance in the last few years to obtain atomic structures o... | 29 | nbjili3v | [
"6m06yzp7",
"njlqgih3",
"mw7athol",
"f089bs8r"
] | biomedical_literature_retrieval | scientific |
acf77a450af668568aa5822d47bdbfa1 | mteb/scifact | Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron. | Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain. Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling the ... | [
"AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos. An emerging family of kinases related to the Drosophila Aurora and budding yeast Ipl1 proteins has been implicated in chromosome ... | 1351 | 28369117 | [
"6333347",
"35231675",
"2665425",
"12871281"
] | scientific_claim_retrieval | scientific |
1b596f43c62dc75d23107e3cb2f011d0 | mteb/scifact | Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs. | Properties of Commelina yellow mottle virus's complete DNA sequence, genomic discontinuities and transcript suggest that it is a pararetrovirus.. The non-enveloped bacilliform viruses are the second group of plant viruses known to possess a genome consisting of circular double-stranded DNA. We have characterized the vi... | [
"Pseudoknots: RNA Structures with Diverse Functions. RNA molecules fulfill a diverse set of biological functions within cells, from the transfer of genetic information from DNA to protein, to enzymatic catalysis. Reflecting this range of roles, simple linear strings of RNA—made up of uracil, guanine, cytosine, and ... | 278 | 14376683 | [
"1383826",
"44737533",
"24221369",
"21230110"
] | scientific_claim_retrieval | scientific |
470cdd4f72d20e5966ea855fb21a91b0 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Linkages of acute care and emergency medical services to state and local public health programs: the role of interactive information systems for responding to events resulting in mass injury() | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | c5tw8458 | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
f512b8fbbf1b2690735968e70359a770 | mteb/trec-covid | what are the transmission routes of coronavirus? | Editorial overview: Emerging viruses: interspecies transmission: Expect the unexpected | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | khupyfj8 | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
3a5ad9d848bb91aaa5475fc8ca09a4ba | mteb/scifact | The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression. | Microarrays for the study of viral gene expression during human cytomegalovirus latent infection.. Human cytomegalovirus (HCMV) is one of the largest known DNA viruses. It is ubiquitous, and following resolution of primary productive infection, it persists in the human host by establishing a lifelong latent infection i... | [
"Analysis of Epstein-Barr virus-regulated host gene expression changes through primary B-cell outgrowth reveals delayed kinetics of latent membrane protein 1-mediated NF-κB activation.. Epstein-Barr virus (EBV) is an oncogenic human herpesvirus that dramatically reorganizes host gene expression to immortalize prima... | 1224 | 21932050 | [
"23305884",
"20675284",
"26133404",
"37762357"
] | scientific_claim_retrieval | scientific |
e46b6981156a284db7056d0b6bb79e01 | mteb/scifact | N348I mutations cause resistance to nevirapine. | N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance. Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almos... | [
"Replication Fork Stability Confers Chemoresistance in BRCA-deficient Cells. Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymera... | 822 | 15319019 | [
"4444861",
"40127292",
"8892905",
"46346525"
] | scientific_claim_retrieval | scientific |
cff474248ad19ad566573b61a17e49ea | mteb/scifact | Pyridostatin induces double-strand breaks accumulation. | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand ... | [
"Break-induced telomere synthesis underlies alternative telomere maintenance. Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10–15% of human cancers.... | 997 | 16472469 | [
"4401289",
"1006165",
"41403996",
"4444861"
] | scientific_claim_retrieval | scientific |
d817a102533d9c0f7ec7c8c0dd0031b7 | mteb/scifact | Replacement of OCT4 and SOX2 genes with GATA3 has the ability to reprogram human cells. | Reprogramming of human fibroblasts to pluripotency with lineage specifiers.. Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors have enhanced our understanding of the reprogramming process.... | [
"A core Klf circuitry regulates self-renewal of embryonic stem cells. Embryonic stem (ES) cells are unique in their ability to self-renew indefinitely and maintain pluripotency. These properties require transcription factors that specify the gene expression programme of ES cells. It has been possible to reverse the... | 1037 | 16287725 | [
"22150633",
"12922760",
"6054657",
"11011905"
] | scientific_claim_retrieval | scientific |
19e09a7acc75145e5230554ba9dce194 | mteb/scifact | Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions. | The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.. Neutrophils rapidly undergo polarization and directional movement to infiltrate the sites of infection and inflammation. Here, we show that an inhibitory MHC I receptor, Ly49Q, was crucial for the swift pol... | [
"Hierarchical organization of the plasma membrane: investigations by single-molecule tracking vs. fluorescence correlation spectroscopy.. Single-molecule tracking and fluorescence correlation spectroscopy (FCS) applied to the plasma membrane in living cells have allowed a number of unprecedented observations, thus ... | 724 | 5531479 | [
"20758340",
"29509926",
"6609935",
"37256966"
] | scientific_claim_retrieval | scientific |
9d00fb050bdda14e1bf8977f6b5cc160 | mteb/trec-covid | What are the observed mutations in the SARS-CoV-2 genome and how often do the mutations occur? | Molecular characterization of SARS-CoV-2 in the first COVID-19 cluster in France reveals an amino acid deletion in nsp2 (Asp268del) | [
"An evaluation of Comparative Genome Sequencing (CGS) by comparing two previously-sequenced bacterial genomes. BACKGROUND: With the development of new technology, it has recently become practical to resequence the genome of a bacterium after experimental manipulation. It is critical though to know the accuracy of t... | 40 | 4c0zwhdh | [
"sabz03c0",
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"b426t461",
"pr8za61l"
] | biomedical_literature_retrieval | scientific |
9fd08995d0f060f744d2195355963923 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Mechanisms of neurological injury in COVID -19 | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | xirw3t6i | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
bb8d1362ea37127f1f1a3fa64fcca193 | mteb/trec-covid | what is known about those infected with Covid-19 but are asymptomatic? | Asymptomatic Patients with Novel Coronavirus Disease (COVID-19) | [
"Functional community structure of African monodominant Gilbertiodendron dewevrei forest influenced by local environmental filtering. Monodominant patches of forest dominated by Gilbertiodendron dewevrei are commonly found in central African tropical forests, alongside forests with high species diversity. Although ... | 27 | 1ix7mtxd | [
"clirh04i",
"mj63cvwe",
"yc8rjjyf",
"v8lpw4r7"
] | biomedical_literature_retrieval | scientific |
dd200937f98708eaee41ae840bbe3d06 | mteb/scifact | The Snf1 complex regulates carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae). | Reconstruction of the yeast Snf1 kinase regulatory network reveals its role as a global energy regulator. Highly conserved among eukaryotic cells, the AMP-activated kinase (AMPK) is a central regulator of carbon metabolism. To map the complete network of interactions around AMPK in yeast (Snf1) and to evaluate the role... | [
"Glucose repression in Saccharomyces cerevisiae. Glucose is the primary source of energy for the budding yeast Saccharomyces cerevisiae. Although yeast cells can utilize a wide range of carbon sources, presence of glucose suppresses molecular activities involved in the use of alternate carbon sources as well as it ... | 1182 | 14541844 | [
"13613916",
"1631583",
"4658268",
"9704467"
] | scientific_claim_retrieval | scientific |
c5b236a80764de4486d4e060d5e34afb | mteb/scifact | Ethanol stress increases the expression of SRL in bacteria. | Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli. Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, ... | [
"Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms.. Nonreplicating and metabolically quiescent bacteria are implicated in latent tuberculosis infections and relapses following \"sterilizing\" chemotherapy. However, evidence linking... | 391 | 1148122 | [
"22908536",
"3943235",
"16546131",
"471735"
] | scientific_claim_retrieval | scientific |
98c08f0a4b05499db49644c7294c0844 | mteb/scifact | Early patent ductus ateriosus (PDA) screening increases in-hospital mortality. | Association Between Early Screening for Patent Ductus Arteriosus and In-Hospital Mortality Among Extremely Preterm Infants.. IMPORTANCE There is currently no consensus for the screening and treatment of patent ductus arteriosus (PDA) in extremely preterm infants. Less pharmacological closure and more supportive managem... | [
"Preterm patent ductus arteriosus: A continuing conundrum for the neonatologist?. How to manage the preterm patent ductus arteriosus (PDA) remains a conundrum. On the one hand, physiology and statistical association with adverse outcomes suggest that it is pathological. On the other hand, clinical trials of treatme... | 368 | 27099731 | [
"25691541",
"25612629",
"34544514",
"21048969"
] | scientific_claim_retrieval | scientific |
cea738a81c7c55492c5e14d1f8d24bea | mteb/scifact | Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus. | G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons. The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic arcuate neurons onto common target sites in the central nervous system has a fundamental role i... | [
"The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.. The pro-drug FTY720 is undergoing phase III clinical trials for prevention of allograft rejection. After phosphorylation, FTY720 targets the G protein-coupled-sphingosine-1-phosphate receptor 1 (S1PR1) on lymphocytes... | 666 | 4469125 | [
"40590358",
"1568684",
"12785130",
"1044552"
] | scientific_claim_retrieval | scientific |
973e0d816219851e6a369f851cf7f8fd | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Indirect Enzyme-Linked Immunosorbent Assay based on the nucleocapsid protein of SARS-like coronaviruses. The nucleocapsid protein (N) is a major structural protein of coronaviruses. The N protein of bat SARS-like coronavirus (SL-CoV) has a high similarity with that of SARS-CoV. In this study, the SL-CoV N protein was e... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | miupbeuy | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
40f7d2cff8f957baa2649faf2c1115c1 | mteb/scifact | T cell receptor /CD3 microdomains are required to induce the immunologic synapse. | T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.. T cell receptor (TCR) signaling is initiated and sustained in microclusters; however, it's not known whether signaling also occurs in the TCR-rich central supramolecular activatio... | [
"TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.. Modified anti-CD3 mAbs are emerging as a possible means of inducing immunologic tolerance in settings including transplantation and autoimmunity such as in type 1 diabetes. In a trial of a modified anti-CD3 mAb ... | 1128 | 9283422 | [
"24069089",
"994800",
"39539647",
"21719289"
] | scientific_claim_retrieval | scientific |
ff36ce678babf6b740e8029a10a89d6c | mteb/scifact | CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency. | 4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors. Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains un... | [
"Differential requirement for CARMA1 in agonist-selected T-cell development.. Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling... | 200 | 18231807 | [
"20344442",
"3531388",
"24923605",
"34905328"
] | scientific_claim_retrieval | scientific |
4043f5581a8c15fe5533e681a662694b | mteb/scifact | Myelin sheaths play a role in action potential propagation. | Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling. This method, based on sp... | [
"Multisite optical recording of excitability in the enteric nervous system.. A multisite optical recording technique consisting of an array of 464 photodiodes was used to measure dynamic changes in transmembrane potentials (Vm) of guinea-pig and mouse enteric neurones stained with the voltage-sensitive dye Di-8-ANE... | 818 | 17814815 | [
"7840442",
"1447990",
"8428837",
"38808600"
] | scientific_claim_retrieval | scientific |
d224b0d637edfdb8fe1f9bf98f7e9a53 | mteb/scifact | Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals. | Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions. The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and other potentially protective antibody responses. The goal... | [
"Characterization of Programmed Death-1 Homologue-1 (PD-1H) Expression and Function in Normal and HIV Infected Individuals. Chronic immune activation that persists despite anti-retroviral therapy (ART) is the strongest predictor of disease progression in HIV infection. Monocyte/macrophages in HIV-infected individua... | 398 | 8883846 | [
"5752492",
"5398179",
"14657344",
"29023309"
] | scientific_claim_retrieval | scientific |
8de06d293221912e8b34f07ce75df282 | mteb/scifact | There is a relation between Erythromycin use and hypertrophic pyloric stenosis. | Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study. OBJECTIVE To assess the association between use of macrolide antibiotics in mothers and infants from pregnancy onset until 120 days after birth and infantile hypertrophic pyloric stenosis (IHPS). DESIGN N... | [
"Dealing with substantial heterogeneity in Cochrane reviews. Cross-sectional study. BACKGROUND Dealing with heterogeneity in meta-analyses is often tricky, and there is only limited advice for authors on what to do. We investigated how authors addressed different degrees of heterogeneity, in particular whether they... | 1289 | 21239672 | [
"7547329",
"22707413",
"52887689",
"35186640"
] | scientific_claim_retrieval | scientific |
232c4086e06b1389e8fea82d5ddeff2a | mteb/scifact | Physical activity does not improve cognitive function in individuals with Alzheimers. | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.. CONTEXT Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. OBJECTIVE To determine whether physical a... | [
"Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors. Hypofunction of the N-methyl D-aspartate subtype of glutamate receptor (NMDAR) is hypothesized to be a mechanism underlying cognitive dysfunction in individuals with schizophrenia. For the schizophrenia-linked ge... | 944 | 1642727 | [
"26688294",
"14460402",
"16787954",
"10010651"
] | scientific_claim_retrieval | scientific |
7c18e23ad758fcff6adb606582ba2cf2 | mteb/scifact | A high microerythrocyte count protects against severe anemia in homozygous alpha (+)- thalassemia trait subjects. | Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia. BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygous for... | [
"Cell-mediated immunity and antibody responses elicited by attenuated Salmonella enterica Serovar Typhi strains used as live oral vaccines in humans.. The development of improved typhoid vaccines is a high global public health priority. However, their development has been hampered by a lack of information regarding... | 41 | 18174210 | [
"18275697",
"36642096",
"6315132",
"12428137"
] | scientific_claim_retrieval | scientific |
4842ff147e3638904cc3b04132cee722 | mteb/scifact | IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING. | IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP). Other putative DNA recept... | [
"Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition. Neuregulin 1 (NRG1) is a secreted trophic factor that activates the postsynaptic erbB4 receptor tyrosine kinase. Both NRG1 and erbB4 have been repeatedly associated with schizophrenia, but their downstream targets are not ... | 542 | 19688024 | [
"13189693",
"27306942",
"9680193",
"13902570"
] | scientific_claim_retrieval | scientific |
968cd5264faf1b9f4b6d5aae795e085e | mteb/scifact | Lack of FGF21 in mice leads to reduced lifespan. | Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts... | [
"CD28 and ITK signals regulate autoreactive T cell trafficking. Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the co-inhibitory receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) develop fatal autoimmunity characterized by lymphocytic... | 682 | 9315213 | [
"2462673",
"18987782",
"17333231",
"9513785"
] | scientific_claim_retrieval | scientific |
7cc312727c9871cd93c73469717145e0 | mteb/trec-covid | How has the COVID-19 pandemic impacted violence in society, including violent crimes? | Coping Behaviors Mediate Associations between Occupational Factors and Compassion Satisfaction among the Intimate Partner Violence and Sexual Assault Workforce. The intimate partner violence (IPV) and sexual assault (SA) workforce faces significant occupational stressors yet little is known about positive occupational ... | [
"Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases.. The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, whi... | 43 | 1kiaolgu | [
"72s8wpla",
"vggfbym5",
"hs2vni8z",
"sch7zhx7"
] | biomedical_literature_retrieval | scientific |
a92fb518732ec09d7bd4f7e08f54c04c | mteb/scifact | Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver. | Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.. Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manipulati... | [
"A lineage of myeloid cells independent of Myb and hematopoietic stem cells.. Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive... | 89 | 7521113 | [
"22973574",
"12827098",
"279052",
"9076196"
] | scientific_claim_retrieval | scientific |
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