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Single-cell genomics is heavily dependent on increasing the copies of DNA found in the cell so there is enough to be sequenced. This has led to the development of strategies for whole genome amplification (WGA). Currently WGA strategies can be grouped into three categories:
* Controlled priming and PCR Amplification: ... | 1 | Biochemistry |
In the presence of lithium or aluminum amide bases, epoxides may open to give the corresponding allylic alcohols. Removal of a proton adjacent to the epoxide, elimination, and neutralization of the resulting alkoxide lead to synthetically useful allylic alcohol products. In reactions of chiral, non-racemic epoxides, th... | 0 | Organic Chemistry |
Glutamatergic means "related to glutamate". A glutamatergic agent (or drug) is a chemical that directly modulates the excitatory amino acid (glutamate/aspartate) system in the body or brain. Examples include excitatory amino acid receptor agonists, excitatory amino acid receptor antagonists, and excitatory amino acid r... | 1 | Biochemistry |
As previously mentioned 1,3BPG is a metabolic intermediate in the glycolytic pathway. It is created by the exergonic oxidation of the aldehyde in G3P. The result of this oxidation is the conversion of the aldehyde group into a carboxylic acid group which drives the formation of an acyl phosphate bond. This is incidenta... | 5 | Photochemistry |
In 1916, Irving Langmuir presented his model for the adsorption of species onto simple surfaces. Langmuir was awarded the Nobel Prize in 1932 for his work concerning surface chemistry. He hypothesized that a given surface has a certain number of equivalent sites to which a species can “stick”, either by physisorption... | 7 | Physical Chemistry |
Application of the [4+4] photocycloaddition is scarce because of competition with the [[2+2 Photocycloaddition|[2+2] cycloaddition]]. However, when accessible, this method can be used to build 8-membered ring with complex stereocenters and structures in one step, as is seen in proposed syntheses for Taxol and molecules... | 5 | Photochemistry |
Another technique that has been gaining ground for single molecule experiments is the use of optical tweezers for applying mechanical forces on molecules. A strongly focused laser beam has the ability to catch and hold particles (of dielectric material) in a size range from nanometers to micrometers. The trapping actio... | 7 | Physical Chemistry |
Once mRNA is purified, an oligo-dT primer (a short sequence of deoxy-thymidine nucleotides) is bound to the poly-A tail of the RNA. The primer is required to initiate DNA synthesis by the enzyme reverse transcriptase. This results in the creation of RNA-DNA hybrids where a single strand of complementary DNA is bound to... | 1 | Biochemistry |
Absorption of light and energy transfer (or conversion) involves colored molecules that can transfer electromagnetic energy, commonly in the form of a laser light source, to other molecules in another form of energy, such as thermal or electrical. These laser addressable colorants, also called near-infrared absorbers, ... | 5 | Photochemistry |
Liquid chromatography is a method of physical separation in which the components of a liquid mixture are distributed between two immiscible phases, i.e., stationary and mobile. The practice of LC can be divided into five categories, i.e., adsorption chromatography, partition chromatography, ion-exchange chromatography,... | 3 | Analytical Chemistry |
Non-B DB is a database integrating annotations and analysis of non-B DNA-forming sequence motifs. The database provides alternative DNA structure predictions including Z-DNA motifs, quadruplex-forming motifs, inverted repeats, mirror repeats and direct repeats and their associated subsets of cruciforms, triplex and sli... | 4 | Stereochemistry |
Global sensitivity measures such as the Hill coefficient do not characterise the local behaviours of the s-shaped curves. Instead, these features are well captured by the response coefficient measure defined as:
In systems biology, such system responses are referred to as control coefficients. Specifically, the concen... | 1 | Biochemistry |
Each one of the assumptions listed below adds to the complexity of the problems solution. As the density of a gas increases with rising pressure, the intermolecular forces play a more substantial role in gas behavior which results in the ideal gas law no longer providing "reasonable" results. At the upper end of the en... | 7 | Physical Chemistry |
The change and degradation in electron backscatter patterns (EBSPs) provide information about the diffracting volume. Pattern degradation (i.e., diffuse quality) can be used to assess the level of plasticity through the pattern/image quality (IQ), where IQ is calculated from the sum of the peaks detected when using the... | 7 | Physical Chemistry |
In physics, a bipolaron is a bound pair of two polarons. An electron in a material may cause a distortion in the underlying lattice. The combination of electron and distortion (which may also be understood as a cloud of phonons) is known as a polaron (in part because the interaction between electron and lattice is via ... | 7 | Physical Chemistry |
Each phycobiliprotein has a specific absorption and fluorescence emission maximum in the visible range of light. Therefore, their presence and the particular arrangement within the phycobilisomes allow absorption and unidirectional transfer of light energy to chlorophyll a of the photosystem II. In this way, the cells ... | 5 | Photochemistry |
Adenosinergic means "working on adenosine".
An adenosinergic agent (or drug) is a chemical which functions to directly modulate the adenosine system in the body or brain. Examples include adenosine receptor agonists, adenosine receptor antagonists (such as caffeine), and adenosine reuptake inhibitors. | 1 | Biochemistry |
Bacteria depend on transcription-translation coupling for genome integrity, termination of transcription and control of mRNA stability. Consequently, artificial disruption of transcription-translation coupling impairs the fitness of bacteria. Without coupling, genome integrity is compromised as stalled transcription co... | 1 | Biochemistry |
A common error in thermocouple construction is related to cold junction compensation. If an error is made on the estimation of , an error will appear in the temperature measurement. For the simplest measurements, thermocouple wires are connected to copper far away from the hot or cold point whose temperature is measure... | 8 | Metallurgy |
Model systems consisting of a single phospholipid or a mixture have been studied by physical chemists. Cardiolipin is found mainly in mitochondrial membranes, and calcium ions play an important role in the respiratory processes mediated by the mitochondrion. The forces involved have been postulated to explain this proc... | 1 | Biochemistry |
Use of cyclooctanone is almost nonexistent drug chemistry with only 2 known exceptions:
#Blonanserin
#Iprindole | 0 | Organic Chemistry |
Vargulin, also called Cypridinid luciferin, Cypridina luciferin, or Vargula luciferin, is the luciferin found in the ostracod Cypridina hilgendorfii, also named Vargula hilgendorfii. These bottom dwelling ostracods emit a light stream into water when disturbed presumably to deter predation. Vargulin is also used by the... | 1 | Biochemistry |
When a protein folds, the titratable amino acids in the protein are transferred from a solution-like environment to an environment determined by the 3-dimensional structure of the protein. For example, in an unfolded protein, an aspartic acid typically is in an environment which exposes the titratable side chain to wat... | 7 | Physical Chemistry |
De Silva et al. constructed an OR molecular logic gate using an aza-crown ether receptor and sodium and potassium ions as the inputs. Either of the two ions could bind to the crown ether, causing the PET to be quenched and the fluorescence to be turned on. Since either of the two ions (input “1”) could turn on the fluo... | 6 | Supramolecular Chemistry |
TaqMan probes consist of a fluorophore covalently attached to the 5’-end of the oligonucleotide probe and a quencher at the 3’-end. Several different fluorophores (e.g. 6-carboxyfluorescein, acronym: FAM, or tetrachlorofluorescein, acronym: TET) and quenchers (e.g. tetramethylrhodamine, acronym: TAMRA) are available. T... | 1 | Biochemistry |
Both aerobic exercise and strength training (resistance exercise) attenuate myostatin expression, and myostatin inactivation potentiates the beneficial effects of endurance exercise on metabolism. | 1 | Biochemistry |
It is thought that early scleraxis-expressing progenitor cells lead to the eventual formation of tendon tissue and other muscle attachments. Scleraxis is involved in mesoderm formation and is expressed in the syndetome (a collection of embryonic tissue that develops into tendon and blood vessels) of developing somites... | 1 | Biochemistry |
The Owens/Wendt theory (after D. K. Owens and R. C. Wendt) divides the surface energy into two components: surface energy due to dispersive interactions and surface energy due to polar interactions. This theory is derived from the combination of Youngs relation, which relates the contact angle to the surface energies o... | 7 | Physical Chemistry |
K2.3 is found in the central nervous system (CNS), muscle, liver, pituitary, prostate, kidney, pancreas and vascular endothelium tissues. K2.3 is most abundant in regions of the brain, but has also been found to be expressed in significant levels in many other peripheral tissues, particularly those rich in smooth muscl... | 1 | Biochemistry |
A light-induced fluorescence transient (LIFT) is a device to remotely measure chlorophyll fluorescence in plants in a fast and non-destructive way. By using a series of excitation light pulses, LIFT combines chlorophyll fluorescence data with spectral and RGB information to provide insights into various photosynthetic ... | 5 | Photochemistry |
RNA polymerase 1 (also known as Pol I) is, in higher eukaryotes, the polymerase that only transcribes ribosomal RNA (but not 5S rRNA, which is synthesized by RNA polymerase III), a type of RNA that accounts for over 50% of the total RNA synthesized in a cell. | 1 | Biochemistry |
Poolman was born in 1959 as the first son of Jelto Poolman and Neeltje Prinsse. In 1983 he married Heleen Stevenson (1959), with whom he has four children. | 0 | Organic Chemistry |
Fluo-4 is used to measure calcium (Ca) concentrations inside living cells, and is often used for high-throughput screening of receptor ligands and calcium permeable ion channels.
The green-fluorescent calcium indicator, Fluo-4, is an improved version of the calcium indicator, Fluo-3. It is commonly used as the non-fluo... | 1 | Biochemistry |
Of the hundreds of facet arrangements that have been used, the most famous is probably the round brilliant cut, used for diamond and many colored gemstones. This first early version of what would become the modern Brilliant Cut is said to have been devised by an Italian named Peruzzi, sometime in the late 17th century.... | 3 | Analytical Chemistry |
The logging system is often simply a personal computer. In initial signal processing, the signal often needs to be amplified and converted for use with the control system. The lines of communication between monochromator, detector output, and computer should be optimized to ensure the desired metrics and features are b... | 7 | Physical Chemistry |
As described above, contact angle is used to characterize surface wettability. A droplet of solvent, typically water for hydrophobic surfaces, is placed perpendicular to the surface. The droplet is imaged and the angle between the solid/liquid and liquid/vapor interfaces is measured. Samples are considered to be superh... | 7 | Physical Chemistry |
Many polymers are attacked by UV radiation at vulnerable points in their chain structures. Thus, polypropylene suffers severe cracking in sunlight unless anti-oxidants are added. The point of attack occurs at the tertiary carbon atom present in every repeat unit, causing oxidation and finally chain breakage. Polyethyle... | 7 | Physical Chemistry |
Drospirenone (DRSP) is used by itself as a progestogen-only birth control pill, in combination with the estrogens ethinylestradiol (EE) or estetrol (E4), with or without supplemental folic acid (vitamin B), as a combined birth control pill, and in combination with the estrogen estradiol (E2) for use in menopausal hormo... | 4 | Stereochemistry |
In chemistry, a Haworth projection is a common way of writing a structural formula to represent the cyclic structure of monosaccharides with a simple three-dimensional perspective. Haworth projection approximate the shapes of the actual molecules better for furanoses—which are in reality nearly planar—than for pyranose... | 4 | Stereochemistry |
Silver nitrate is a salt of silver that is sometimes used by dentists as a caustic material to cauterize mouth sores, and has in the past been used by physicians for treating wounds. It may be an appropriate material to salt the earth after burying a monster that has been killed with silver bullets. | 3 | Analytical Chemistry |
The split gene theory is a theory of the origin of introns, long non-coding sequences in eukaryotic genes between the exons. The theory holds that the randomness of primordial DNA sequences would only permit small (< 600bp) open reading frames (ORFs), and that important intron structures and regulatory sequences are de... | 1 | Biochemistry |
Many chloroplast DNAs contain two inverted repeats, which separate a long single copy section (LSC) from a short single copy section (SSC).
While a given pair of inverted repeats are rarely completely identical, they are always very similar to each other, apparently resulting from concerted evolution.
The inverted repe... | 5 | Photochemistry |
Walter McCrone was born in Wilmington, Delaware, but he grew up mostly in New York State. His father was a civil engineer in charge of one of the first DuPont plants to manufacture cellophane. McCrone received a bachelors degree in chemistry from Cornell University in 1938 and a Ph.D. in organic chemistry from the sa... | 3 | Analytical Chemistry |
A homocycle or homocyclic ring is a ring in which all atoms are of the same chemical element. A heterocycle or heterocyclic ring is a ring containing atoms of at least two different elements, i.e. a non-homocyclic ring. A carbocycle or carbocyclic ring is a homocyclic ring in which all of the atoms are carbon. An impor... | 4 | Stereochemistry |
In scattering theory, a scattering channel is a quantum state of the colliding system before or after the collision (). The Hilbert space spanned by the states before collision (in states) is equal to the space spanned by the states after collision (out states) which are both Fock spaces if there is a mass gap. This ... | 7 | Physical Chemistry |
One goal of structural genomics is to identify novel protein folds. Experimental methods of protein structure determination require proteins that express and/or crystallize well, which may inherently bias the kinds of proteins folds that this experimental data elucidate. A genomic, modeling-based approach such as ab in... | 1 | Biochemistry |
Conventional radioisotope thermoelectric generators (RTGs) used to power spacecraft use a radioactive material whose radiation is used to heat a block of material and then converted to electricity using a thermocouple. Thermocouples are very inefficient and their replacement with TPV could offer significant improvement... | 7 | Physical Chemistry |
With deep WGS data of cfDNA from a carcinoma of unknown primary patient with very low ctDNA concentration quantified, they trained a machine learning model using bootstrapping. The results of RNA-sequencing on PBMC runs for the 5 different patients are recorded and the average of 3 of these individuals expression level... | 1 | Biochemistry |
There are several ways to mathematically define quasicrystalline patterns. One definition, the "cut and project" construction, is based on the work of Harald Bohr (mathematician brother of Niels Bohr). The concept of an almost periodic function (also called a quasiperiodic function) was studied by Bohr, including work ... | 3 | Analytical Chemistry |
In adults, the primary metabolic pathway for paracetamol is glucuronidation. This yields a relatively non-toxic metabolite, which is excreted into bile and passed out of the body. A small amount of the drug is metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1) into NAPQI, which is extremel... | 1 | Biochemistry |
Fraser-Reid was born in Coleyville, Jamaica to William, an elementary school principal, and Laura, a teacher. He had five older siblings. Laura died when Fraser-Reid was only nine months old. He attended Excelsior High School and Clarendon College before moving to Canada to earn BSc (1959) and MSc (1961) at Queen's Uni... | 0 | Organic Chemistry |
Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.
Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pentose sugar, either ribose or deoxyribose, and one... | 1 | Biochemistry |
The simplest method to measure the electrical resistance of a sample of some material is to place it in an electrical circuit in series with a current source I and measure the resulting voltage V across the sample. The resistance of the sample is given by Ohms law as R = V / I'. If the voltage is zero, this means that ... | 7 | Physical Chemistry |
MiRNA expression profiles are altered in psychiatric conditions, including depression, anxiety, and PTSD. It has been demonstrated that miR-324-5p expression is altered in the brains of suicide victims with depression and in the amygdala, the fear center of the brain, in PTSD. MiRNAs are an underexplored potential biom... | 1 | Biochemistry |
For an Authority Having Jurisdiction, combustibility is defined by the local code. In the National Building Code of Canada, it is defined as follows:
*Combustible: A material that fails to meet acceptance criteria of [https://web.archive.org/web/20061003193651/http://www.ulc.ca/About_ulc/Publication_Notice_Detail.asp?P... | 7 | Physical Chemistry |
Jiří Drahoš (born 20 February 1949; ) is a Czech physical chemist and politician who has been the Senator of Prague 4 since October 2018. Previously, Drahoš served as President of the Czech Academy of Sciences from 2009 to 2017, and was a candidate in the 2018 Czech presidential election.
Born in Český Těšín and raise... | 7 | Physical Chemistry |
The calcium salt of atorvastatin is marketed under the trade name Lipitor for the lowering of blood cholesterol. The first enantioselective medicinal chemistry route to atorvastatin relied on a diastereoselective aldol reaction with a chiral ester to set one of the two alcohol stereocenters. In the commercial route to ... | 4 | Stereochemistry |
The usage of the term canonical sequence to refer to a promoter is often problematic, and can lead to misunderstandings about promoter sequences. Canonical implies perfect, in some sense.
In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under specif... | 1 | Biochemistry |
PPA is known to have a rigid and brittle backbone which limits its flexibility and usage in some applications. However, it can be easily tuned by adding additives rendering it a soft material. The mechanical properties of cyclic PPA films drop cast using different solvents have recently been investigated. The study sho... | 7 | Physical Chemistry |
The ocean's chemistry is changing due to the uptake of anthropogenic carbon dioxide (CO). Ocean pH, carbonate ion concentrations ([CO]), and calcium carbonate mineral saturation states (Ω) have been declining as a result of the uptake of approximately 30% of the anthropogenic carbon dioxide emissions over the past 270 ... | 9 | Geochemistry |
Metal substrates for use in SAMs can be produced through physical vapor deposition techniques, electrodeposition or electroless deposition. Thiol or selenium SAMs produced by adsorption from solution are typically made by immersing a substrate into a dilute solution of alkane thiol in ethanol, though many different sol... | 6 | Supramolecular Chemistry |
Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins produce messenger RNA (mRNA). Other segments of DNA are transcribed into RNA molecules called non-coding RNAs (ncRNAs).
Both DNA and RNA are nucleic acids, which use base pairs ... | 1 | Biochemistry |
Analytical technique is a method used to determine a chemical or physical property of a chemical substance, chemical element, or mixture. There is a wide variety of techniques used for analysis, from simple weighing to advanced techniques using highly specialized instrumentation. | 3 | Analytical Chemistry |
When there is excess glucose, coenzyme A is used in the cytosol for synthesis of fatty acids. This process is implemented by regulation of acetyl-CoA carboxylase, which catalyzes the committed step in fatty acid synthesis. Insulin stimulates acetyl-CoA carboxylase, while epinephrine and glucagon inhibit its activity.
D... | 1 | Biochemistry |
*EIF1 aka SUI1
*EIF1AD
*EIF1B
*EIF2A
*EIF2AK1
*EIF2AK3
*EIF2AK4
*EIF2AK1
*EIF2B2
*EIF2B3
*EIF2B4
*EIF2S2
*EIF3A
*EIF3B
*EIF3D formerly EIF3S4
*EIF3G
*EIF3I
*EIF3H
*EIF3J
*EIF3K
*EIF3L
*EIF3M
*EIF3S5
*EIF3S8
*EIF4A1
*EIF4A2
*EIF4A3
*EIF4E2
*EIF4G1
*EIF4G2
*EIF4G3
*EIF4H
*EIF5
*EIF5
*EIF5A
*EIF5AL1
*EIF5B
*EIF6
*TUFM... | 1 | Biochemistry |
Arsenic is a ubiquitous naturally occurring chemical element, and the 20th most common element on Earth. Arsenic levels in the groundwater vary from around 0.5 parts per billion to 5000 parts per billion, depending on an area's geologic features, and possible presence on industrial waste. The highest groundwater arseni... | 1 | Biochemistry |
In the Gattermann reaction, benzenediazonium chloride is warmed with copper powder and HCl or HBr to produce chlorobenzene and bromobenzene respectively. It is named after the German chemist Ludwig Gattermann. | 0 | Organic Chemistry |
A SPARROW model is a SPAtially-Referenced Regression on Watershed attributes, which helps integrate water quality data with landscape information. More specifically the USGS used this model to display long-term changes within watersheds to further explain in-stream water measurement in relation to upstream sources, wat... | 9 | Geochemistry |
Light-emitting materials that can convert non-emissive triplet states into emissive singlet states are crucial in organic light-emitting diodes (OLEDs) as, statistically, 75% of the excited states formed in an OLED are triplet states. TTA materials are well suited to use in OLEDs due to their low operational voltage, s... | 7 | Physical Chemistry |
The Bunsen–Kirchhoff Award is a prize for "outstanding achievements" in the field of analytical spectroscopy. It has been awarded since 1990 by the German Working Group for Applied Spectroscopy, and is endowed with by PerkinElmer, Germany. The prize is named in honor of chemist Robert Bunsen and physicist Gustav Kirch... | 3 | Analytical Chemistry |
Cefalexin can treat a number of bacterial infections including otitis media, streptococcal pharyngitis, bone and joint infections, pneumonia, cellulitis, and urinary tract infections. It may be used to prevent bacterial endocarditis. It can also be used for the prevention of recurrent urinary-tract infections.
Cefalexi... | 4 | Stereochemistry |
A pure stoichiometric mixture may be obtained by water electrolysis, which uses an electric current to dissociate the water molecules:
: Electrolysis:
: Combustion:
William Nicholson was the first to decompose water in this manner in 1800. In theory, the input energy of a closed system always equals the output energy... | 7 | Physical Chemistry |
Longifolene is the common (or trivial) chemical name of a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins. The name is derived from that of a pine species from which the compound was isolated,
Chemically, longifolene is a tricyclic sesquiterpene. This ... | 0 | Organic Chemistry |
For an introduction to the theory of electron diffraction, see part 2 of Williams and Carter's Transmission Electron Microscopy text
While it is clear that precession reduces many of the dynamical diffraction effects that plague other forms of electron diffraction, the resulting patterns cannot be considered purely kin... | 3 | Analytical Chemistry |
In his 50-year career, Ferrier published 180 papers, reviews and books, and gave 10 invited plenary lectures at international symposia. His reviews were of particular benefit to the chemical community but perhaps of most value was the book "Monosaccharide Chemistry, written with Dr Peter Collins in 1972 and majorly upd... | 0 | Organic Chemistry |
DSSCs degrade when exposed to light. In 2014 air infiltration of the commonly-used amorphous Spiro-MeOTAD hole-transport layer was identified as the primary cause of the degradation, rather than oxidation. The damage could be avoided by the addition of an appropriate barrier.
The barrier layer may include UV stabilizer... | 5 | Photochemistry |
There is a pressure difference between the outside air and the air inside the building caused by the difference in temperature between the outside air and the inside air. That pressure difference ( ΔP ) is the driving force for the stack effect and it can be calculated with the equations presented below. The equations ... | 7 | Physical Chemistry |
Iodic acid can be produced by oxidizing iodine with strong oxidizers such as nitric acid , chlorine , chloric acid or hydrogen peroxide , for example:
Iodic acid is also produced by the reaction of iodine monochloride with water: | 3 | Analytical Chemistry |
The Fischer–Tropsch process involves a series of chemical reactions that produce a variety of hydrocarbons, ideally having the formula (CH). The more useful reactions produce alkanes as follows:
: (2n + 1) H + n CO → CH + n HO
where n is typically 10–20. The formation of methane (n = 1) is unwanted. Most of the alkanes... | 0 | Organic Chemistry |
In organic chemistry, phosphonates or phosphonic acids are organophosphorus compounds containing groups (where R = alkyl, aryl, or just hydrogen). Phosphonic acids, typically handled as salts, are generally nonvolatile solids that are poorly soluble in organic solvents, but soluble in water and common alcohols.
Many ... | 0 | Organic Chemistry |
Before the discovery of msDNA in myxobacteria, a group of swarming, soil-dwelling bacteria, it was thought that the enzymes known as reverse transcriptases (RT) existed only in eukaryotes and viruses. The discovery led to an increase in research of the area. As a result, msDNA has been found to be widely distributed am... | 1 | Biochemistry |
Near Eastern development of bronze technology spread across Central Asia by way of the Eurasian Steppes, and with it came the knowledge and technology for tin prospection and extraction. By 2000 to 1500 BC Uzbekistan, Afghanistan, and Tajikistan appear to have exploited their sources of tin, carrying the resources east... | 8 | Metallurgy |
Expose-R (R stands for its mounting on the Russian module Zvezda) was mounted by Russian cosmonauts extravehicular activity on 11 March 2009 and the exposure to outer space conditions continued for 682 days until 21 January 2011, when it was brought back to Earth by the last Discovery Shuttle flight STS-133 on 9 March ... | 1 | Biochemistry |
Cyclic α,β-unsaturated ketones are the most commonly employed substrates for vicinal difunctionalization. They tend to be more reactive than acyclic analogues and undergo less direct addition than aldehydes. Amides and esters can be used to encourage conjugate addition in cases when direct addition may be competitive (... | 0 | Organic Chemistry |
DPPA undergoes pseudohalogen replacement of the azido group by treatment with nucleophilic reagents, such as ammonia and various amines.
This compound is used as a reagent for the synthesis of peptides by virtue of its reactions with carboxylic acids leading to either the urethane or the amide. The formation of the ure... | 0 | Organic Chemistry |
For different purposes, different combinations of spectral bands can be used. They are usually represented with red, green, and blue channels. Mapping of bands to colors depends on the purpose of the image and the personal preferences of the analysts. Thermal infrared is often omitted from consideration due to poor spa... | 7 | Physical Chemistry |
For a planet around another star, (the incident stellar flux on the planet) is not a readily measurable quantity. To find the equilibrium temperature of such a planet, it may be useful to approximate the host star's radiation as a blackbody as well, such that:
The luminosity () of the star, which can be measured from o... | 7 | Physical Chemistry |
From the mathematical point of view the Lippmann–Schwinger equation in coordinate representation is an integral equation of Fredholm type. It can be solved by discretization. Since it is equivalent to the differential time-independent Schrödinger equation with appropriate boundary conditions, it can also be solved by n... | 7 | Physical Chemistry |
The final STQ-77/FET framework classifies temperament traits and their neurochemical biomarkers into 12 components: nine components regulating the formal functional aspects of behaviour (energetic, dynamic and orientational) each assessed in three domains (intellectual, physical and social-verbal); also three component... | 1 | Biochemistry |
A Luggin capillary (also Luggin probe, Luggin tip, or Luggin-Haber capillary) is a small tube that is used in electrochemistry. The capillary defines a clear sensing point for the reference electrode near the working electrode. This is in contrast to the poorly defined, large reference electrode. | 7 | Physical Chemistry |
During the assay, a fraction of the free receptor is captured by the solid phase ligand and subsequently labeled with a fluorescent secondary molecule (Figure 1). The short contact time with the solid phase does not allow significant dissociation of the pre-formed complexes in the solution. Solution dissociation is thu... | 1 | Biochemistry |
Even when working with ordinary eukaryotic sequences such as the Yeast genome, it is often desired to be able to use alternative translation tables—namely for translation of the mitochondrial genes. Currently the following translation tables are defined by the NCBI Taxonomy Group for the translation of the sequences in... | 1 | Biochemistry |
As expected, the concentration of the unknown will have some error which can be calculated from the formula below. This formula assumes that a linear relationship is observed for all the standards. It is important to note that the error in the concentration will be minimal if the signal from the unknown lies in the mid... | 1 | Biochemistry |
Partition chromatography was one of the first kinds of chromatography that chemists developed, and is barely used these days. The partition coefficient principle has been applied in paper chromatography, thin layer chromatography, gas phase and liquid–liquid separation applications. The 1952 Nobel Prize in chemistry wa... | 3 | Analytical Chemistry |
Many proteins are glycosylated on certain residues, which can affect the proteome.
Glycans can interact with receptors, which in turn affect their cellular and subcellular localization. For example, cytokines and the subgroup chemokines are small signaling proteins that are involved in the immune response. Many of the ... | 1 | Biochemistry |
Immunofluorescence is only limited to fixed (i.e. dead) cells, when studying structures within the cell, as antibodies generally do not penetrate intact cellular or subcellular membranes in living cells, because they are large proteins. To visualize these structures, antigenic material must be fixed firmly on its natur... | 1 | Biochemistry |
Oxidizing roasting, the most commonly practiced roasting process, involves heating the ore in excess of air or oxygen, to burn out or replace the impurity element, generally sulfur, partly or completely by oxygen. For sulfide roasting, the general reaction can be given by:
:2MS (s) + 3O (g) -> 2MO (s) + 2SO (g)
Roa... | 8 | Metallurgy |
Increases in the intracellular Ca concentrations are often a result of IP activation. When a ligand binds to a G protein-coupled receptor (GPCR) that is coupled to a Gq heterotrimeric G protein, the α-subunit of Gq can bind to and induce activity in the PLC isozyme PLC-β, which results in the cleavage of PIP into IP an... | 1 | Biochemistry |
The phase change material should possess the following thermodynamic properties:
* Melting temperature in the desired operating temperature range
* High latent heat of fusion per unit volume
* High specific heat, high density, and high thermal conductivity
* Small volume changes on phase transformation and small vapor ... | 7 | Physical Chemistry |
Lakes and oceans appear cyan for several reasons. One is that the surface of the water reflects the color of the sky, which ranges from cyan to light azure. It is a common misconception that this reflection is the sole reason bodies of water appear cyan, though it can contribute. This contribution usually makes the bod... | 3 | Analytical Chemistry |
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