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Autoreceptor inhibition leads to increase respective neurotransmitter release. Major autoreceptor which clinically important are alpha 2(adrenergic receptor subtype 2), H 3(histamine receptor subtype 3), 5 HT 1(serotonin receptor subtype 1). In which respective drugs act are Clonidine on alpha 2 as Agonist used in hype... | 1 | Gene expression + Signal Transduction |
Tinning is the process of thinly coating sheets of wrought iron or steel with tin, and the resulting product is known as tinplate. The term is also widely used for the different process of coating a metal with solder before soldering.
It is most often used to prevent rust, but is also commonly applied to the ends of st... | 0 | Metallurgy |
Multiple isoforms of the Fas receptor protein are produced by alternative splicing. Two normally occurring isoforms in humans are produced by an exon-skipping mechanism. An mRNA including exon 6 encodes the membrane-bound form of the Fas receptor, which promotes apoptosis, or programmed cell death. Increased expression... | 1 | Gene expression + Signal Transduction |
Viral/prokaryotic RNA-directed RNA polymerases, along with many single-subunit DNA-directed polymerases, employ a fold whose organization has been linked to the shape of a right hand with three subdomains termed fingers, palm, and thumb. Only the palm subdomain, composed of a four-stranded antiparallel beta sheet with ... | 1 | Gene expression + Signal Transduction |
The Albion process is an atmospheric leaching process for processing zinc concentrate, refractory copper and refractory gold. The process is important because it is the most cost-effective method currently in use for extracting both the zinc and lead from concentrates that contain high lead levels (7% or greater). Zinc... | 0 | Metallurgy |
* Platyhelminthes (flatworms) and Nematoda (roundworms).
Code 14 differs from code 9 (the echinoderm and flatworm mitochondrial code) only by translating UAA to Tyr rather than STOP. A study in 2000 has found no evidence that the codon UAA codes for Tyr in the flatworms but other opinions exist. There are very few Ge... | 1 | Gene expression + Signal Transduction |
Bainite can essentially be regarded as martensite that tempers during the course of transformation. It forms at a higher temperature than martensite, and even the latter can autotemper. Because the transformation temperature is higher, the austenite itself is mechanically weak so that the shape deformation due to baini... | 0 | Metallurgy |
Chelating agents, natural zeolite, activated carbon, resins, and liquid organics impregnated with chelating agents are all used to exchange cations or anions with the solution. Selectivity and recovery are a function of the reagents used and the contaminants present. | 0 | Metallurgy |
In bacteria, such as E. coli, genes, are regulated by sequence elements in promoters and related binding sites). RegulonDB provides a database of such regulatory elements, their binding sites and the transcription factors that bind to these sites in E. coli. RegulonDB 9.0 includes 184 experimentally determined transcri... | 1 | Gene expression + Signal Transduction |
Beryllides of cobalt and nickel have metallurgical importance as the precipitated phase in beryllium copper alloys. These materials are nonsparking, which allows them to be used in certain hazardous environments.
In nuclear technology, beryllides are investigated as neutron multipliers. Unlike metallic Be, materials s... | 0 | Metallurgy |
In general terms, chemotaxis is a biological process where living entities, such as cells or organisms, detect, maneuver, and react in response to a chemical signal in their environment. Such a phenomenon is critical for many biological processes, including but not limited to wound healing, detection of food, and avoid... | 1 | Gene expression + Signal Transduction |
Crack growth is reported to be very slow by Luxfer, a major manufacturer of aluminium high-pressure cylinders. Cracks are reported to develop over periods in the order of 8 or more years before reaching a stage where the cylinder is likely to leak, which allows timely detection by properly trained inspectors using eddy... | 0 | Metallurgy |
In 1780, Luigi Galvani discovered that when two different metals (e.g., copper and zinc) are in contact and then both are touched at the same time to two different parts of a muscle of a frog leg, to close the circuit, the frogs leg contracts. He called this "animal electricity". The frogs leg, as well as being a dete... | 0 | Metallurgy |
When choosing between inducing transient or stable expression in cells, time frame and experimental goal must be taken into consideration. Transiently transfected cells are often used to study the effects of short-term gene expression, perform RNA interference (RNAi)‑mediated gene silencing, or quickly generate small-s... | 1 | Gene expression + Signal Transduction |
The project is open source - all data and all software that is produced in the project can be freely accessed and used. | 1 | Gene expression + Signal Transduction |
Centromeres are the sites where spindle fibers attach to newly replicated chromosomes in order to segregate them into daughter cells when the cell divides. Each eukaryotic chromosome has a single functional centromere that is seen as a constricted region in a condensed metaphase chromosome. Centromeric DNA consists of ... | 1 | Gene expression + Signal Transduction |
Neurotransmitters bind to ionotropic receptors on postsynaptic neurons, either causing their opening or closing. The variations in the quantities of neurotransmitters released from the presynaptic neuron may play a role in regulating the effectiveness of synaptic transmission. In fact, the concentration of cytoplasmic ... | 1 | Gene expression + Signal Transduction |
Lowthian Bell (1816–1904) was, like Abraham Darby, the forceful patriarch of an ironmaking dynasty. Both his son Hugh Bell and his grandson Maurice Bell were directors of the Bell iron and steel company. His father, Thomas Bell, was a founder of Losh, Wilson and Bell, an iron and alkali company. The firm had works at W... | 0 | Metallurgy |
Riboses 2 hydroxy group reacts with the phosphate linked 3 hydroxy group, making RNA too unstable to be used or synthesized reliably. To overcome this, a ribose analogue can be used. The most common RNA analogues are 2-O-methyl-substituted RNA, locked nucleic acid (LNA) or bridged nucleic acid (BNA), morpholino, and pe... | 1 | Gene expression + Signal Transduction |
The Krupp-Renn process, which specialized in the beneficiation of poor ores, was the logical basis for the development of recycling processes for ferrous by-products. In 1957, Krupp tested a furnace at for the treatment of roasted pyrites to extract iron (in the form of Luppen) and zinc (vaporized in the flue gases). ... | 0 | Metallurgy |
Grinding is abrasion of the surface of interest by abrasive particles, usually diamond, that are bonded to paper or a metal disc. Grinding erases saw marks, coarsely smooths the surface, and removes stock to a desired depth. A typical grinding sequence for ceramics is one minute on a 240-grit metal-bonded diamond whee... | 0 | Metallurgy |
There are many theories on the kinetics of the bonding process but the most common theory divides the process into four main stages.
The stages are:
# dissolution of the interlayer
# homogenization of the liquid
# isothermal solidification
# homogenization of the bond region | 0 | Metallurgy |
There are several textures that are commonly found in processed (cubic) materials. They are named either by the scientist that discovered them, or by the material they are most found in. These are given in Miller indices for simplification purposes.
*Cube component: (001)[100]
*Brass component: (110)[-112]
*Copper com... | 0 | Metallurgy |
Hot isostatic pressing (HIP) is a manufacturing process, used to reduce the porosity of metals and increase the density of many ceramic materials. This improves the material's mechanical properties and workability.
The process can be used to produce waste form classes. Calcined radioactive waste (waste with additives)... | 0 | Metallurgy |
Ribosomal RNA (rRNA) includes non-coding RNAs that play essential roles in rRNA regulation. Ribosomal RNA (rRNA) takes part in protein synthesis. Occasional RNA molecules act catalytically, as RNA enzymes (ribozymes) or take part in protein export. The most important ribozyme is the major rRNA of the large subunit of t... | 1 | Gene expression + Signal Transduction |
Rust is an iron oxide, a usually reddish-brown oxide formed by the reaction of iron and oxygen in the catalytic presence of water or air moisture. Rust consists of hydrous iron(III) oxides (FeO·nHO) and iron(III) oxide-hydroxide (FeO(OH), Fe(OH)), and is typically associated with the corrosion of refined iron.
Given su... | 0 | Metallurgy |
The initiation time is related to the rate at which carbonation propagates in the concrete cover thickness. Once that carbonation reaches the steel surface, altering the local pH value of the environment, the protective thin film of oxides on the steel surface becomes instable, and corrosion initiates involving an exte... | 0 | Metallurgy |
Typical coatings that can be evaluated with this method are:
*Phosphated (pre-treated) surfaces (with subsequent paint/primer/lacquer/rust preventive)
*Zinc and zinc-alloy plating (see also electroplating). See ISO 4042 for guidance
*Electroplated chromium, nickel, copper, tin
*Coatings not applied electrolytically, su... | 0 | Metallurgy |
Non-stop decay (NSD) is a cellular pathway that identifies and degrades aberrant mRNA transcripts that do not contain a proper stop codon. Stop codons are signals in messenger RNA that signal for synthesis of proteins to end. Aberrant transcripts are identified during translation when the ribosome translates into the p... | 1 | Gene expression + Signal Transduction |
Orthopoxviruses and some other nucleocytoplasmic large DNA viruses synthesize RNA using a virally encoded multi-subunit RNAP. They are most similar to eukaryotic RNAPs, with some subunits minified or removed. Exactly which RNAP they are most similar to is a topic of debate. Most other viruses that synthesize RNA use un... | 1 | Gene expression + Signal Transduction |
Bidirectional transcription at enhancer sites generates comparatively shorter (0.5-2kb) and non-polyadenylated eRNAs. Enhancers that generate polyA- eRNAs have a chromatin signature with a higher H3K4me1/me3 ratio than 1D-eRNAs. In general, enhancer transcription and production of bidirectional eRNAs demonstrate a stro... | 1 | Gene expression + Signal Transduction |
The copper-bronze metallurgy in the Harappan civilization was widespread and had a high variety and quality. The early use of iron may have developed from the practice of copper-smelting. While there is to date no proven evidence for smelted iron in the Indus Valley civilization, iron ore and iron items have been unear... | 0 | Metallurgy |
These second generation mTOR inhibitors bind to ATP-binding site in mTOR kinase domain required for the functions of both mTORC1 and mTORC2, and result in downregulation of mTOR signaling pathway. Due to PI3K and mTORC2 ability to regulate AKT phosphorylation, these two compounds play a key role in minimizing the feedb... | 1 | Gene expression + Signal Transduction |
An example of a repressor protein is the methionine repressor MetJ. MetJ interacts with DNA bases via a ribbon-helix-helix (RHH) motif. MetJ is a homodimer consisting of two monomers, which each provides a beta ribbon and an alpha helix. Together, the beta ribbons of each monomer come together to form an antiparallel b... | 1 | Gene expression + Signal Transduction |
* The compressive residual stresses imparted by laser peening are precisely controlled both in location and intensity and can be applied to mitigate sharp transitions into tensile regions. Laser peening imparts deep compressive residual stresses on the order of 10 to 20 times deeper than conventional shot peening, maki... | 0 | Metallurgy |
The enzyme rhodanase (thiosulfate sulfurtransferase) catalyzes the detoxification of cyanide ion by thiosulfate ion by transforming them into thiocyanate ion and sulfite ion:
Sodium thiosulfate has been considered as an empirical treatment for cyanide poisoning, along with hydroxocobalamin. It is most effective in a pr... | 0 | Metallurgy |
Terfenol-D, an alloy of the formula (x ≈ 0.3), is a magnetostrictive material. It was initially developed in the 1970s by the Naval Ordnance Laboratory in the United States. The technology for manufacturing the material efficiently was developed in the 1980s at Ames Laboratory under a U.S. Navy-funded program. It is n... | 0 | Metallurgy |
Phosphorylation and dephosphorylation of hydroxyl groups belonging to neutral but polar amino acids such as serine, threonine, and tyrosine within specific target proteins is a fundamental part of the regulation of every physiologic process. Phosphorylation involves the covalent modification of the hydroxyl with a phos... | 1 | Gene expression + Signal Transduction |
The principal technology is the cyanide process, in which gold is leached from the ore by treatment with a solution of cyanide. The first step is comminution (grinding) to increase surface area and expose the gold to the extracting solution. The extraction is conducted by dump leaching or heap leaching processes. Sodi... | 0 | Metallurgy |
The solidifying behavior depends on the alloy composition. Pure metals solidify at a certain temperature, forming crystals of one phase. Eutectic alloys also solidify at a single temperature, all components precipitating simultaneously in so-called coupled growth. Non-eutectic compositions on cooling start to first pre... | 0 | Metallurgy |
PHLPP1 and 2 also dephosphorylate the hydrophobic motifs of two classes of the protein kinase C (PKC) family: the conventional PKCs and the novel PKCs. (The third class of PKCs, known as the atypicals, have a phospho-mimetic at the hydrophobic motif, rendering them insensitive to PHLPP.)
The PKC family of kinases con... | 1 | Gene expression + Signal Transduction |
STAT3 has been shown to interact with:
* AR,
* ELP2,
* EP300,
* EGFR,
* HIF1A,
* JAK1,
* JUN
* KHDRBS1,
* mTOR,
* MYOD1,
* NDUFA13,
* NFKB1,
* NR3C1,
* NCOA1,
* PML,
* RAC1,
* RELA,
* RET,
* RPA2,
* STAT1,
* Stathmin,
* Src, and
* TRIP10.
* KPNA4.
Niclosamide seems to inhibit the STAT3 signalling ... | 1 | Gene expression + Signal Transduction |
Upregulation refers to the increase in the number of receptor sites on the membrane. Estrogen and FSH upregulate LHCGR sites in preparation for ovulation. After ovulation, the luteinized ovary maintains LHCGR s that allow activation in case there is an implantation. Upregulation in males requires gene transcription to... | 1 | Gene expression + Signal Transduction |
An application of dendritic growth in directional solidification is gas turbine engine blades which are used at high temperatures and must handle high stresses along the major axes. At high temperatures, grain boundaries are weaker than grains. In order to minimize the effect on properties, grain boundaries are align... | 0 | Metallurgy |
Currently, the stability of most ionic liquids under practical electrochemical conditions is unknown, and the fundamental choice of ionic fluid is still empirical as there is almost no data on metal ion thermodynamics to feed into solubility and speciation models. Also, there are no Pourbaix diagrams available, no stan... | 0 | Metallurgy |
Geometric Dynamic Recrystallization (GDR) is a recrystallization mechanism that has been proposed to occur in several alloys, particularly aluminium, at high temperatures and low strain rates. It is a variant of dynamic recrystallization.
The basic mechanism is that during deformation the grains will be increasingly fl... | 0 | Metallurgy |
In 1961, Israeli archaeologist Pessah Bar-Adon discovered a hoard of Chalcolithic artifacts in a cave on the northern side of Nahal Mishmar, known since as the Treasure Cave. The hoard consisted of 442 decorated objects made of copper and bronze (429 of them), ivory and stone, including 240 mace heads, about 100 scepte... | 0 | Metallurgy |
The eFS assay could be used to analyze other cell or tissue types. By assessing enrichment in GFP-expressing CD2-negative as well as CD2-positive cells, and by crossing a common pool of reporter transformant male flies to females expressing CD2 in different cell types, it is possible to assay specificity as well as act... | 1 | Gene expression + Signal Transduction |
Much of the SIMIBI class of GTPases is activated by dimerization. Named after the signal recognition particle (SRP), MinD, and BioD, the class is involved in protein localization, chromosome partitioning, and membrane transport. Several members of this class, including MinD and Get3, has shifted in substrate specificit... | 1 | Gene expression + Signal Transduction |
There has been a significant amount of work experimentally to observe both the structure and measure the properties of grain boundaries but the five dimensional degrees of freedom of grain boundaries within complex polycrystalline networks has not yet been fully understood and thus there is currently no method to contr... | 0 | Metallurgy |
Biological probe or bio-probes are used to collect samples for microbiological analysis. Microorganisms can accelerate the corrosion process, so monitoring the corrosion caused by them is effective in timely notification and preventive measures. | 0 | Metallurgy |
Gene knockout by mutation is commonly carried out in bacteria. An early instance of the use of this technique in Escherichia coli was published in 1989 by Hamilton, et al. In this experiment, two sequential recombinations were used to delete the gene. This work established the feasibility of removing or replacing a fun... | 1 | Gene expression + Signal Transduction |
A coating is a covering that is applied to the surface of an object, or substrate. The purpose of applying the coating may be decorative, functional, or both. Coatings may be applied as liquids, gases or solids e.g. powder coatings.
Paints and lacquers are coatings that mostly have dual uses, which are protecting the s... | 0 | Metallurgy |
Plithotaxis, from the Greek word "πλήΘος", denotes a crowd, swarm, or throng. In collective cellular migration, plithotaxis is the tendency for each individual cell within a monolayer to migrate along the local orientation of the maximal principal stress, or equivalently, minimal intercellular shear stress. Plithotaxis... | 1 | Gene expression + Signal Transduction |
The tin belt of Southeast Asia extends all the way down to Tasmania, but metals were not exploited in Australia until the arrival of Europeans in the 1780s. | 0 | Metallurgy |
Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP1 and SFRP5 may be involved in determining the polarity of photoreceptor cells in the re... | 1 | Gene expression + Signal Transduction |
Ariconium was a road station of Roman Britain mentioned in Iter XIII of the Iter Britanniarum of the Antonine Itineraries. It was located at Bury Hill in the parish of Weston under Penyard, about east of Ross on Wye, Herefordshire, and about southeast of Hereford. The site existed prior to the Roman era, and then cam... | 0 | Metallurgy |
Chemical metallurgy is the science of obtaining metals from their concentrates, semi products, recycled bodies and solutions, and of considering reactions of metals with an approach of disciplines belonging to chemistry. As such, it involves reactivity of metals and it is especially concerned with the reduction and oxi... | 0 | Metallurgy |
The name NANOG derives from Tír na nÓg (Irish for "Land of the Young"), a name given to the Celtic Otherworld in Irish and Scottish mythology. | 1 | Gene expression + Signal Transduction |
Removal of the chlorides is essential. In practice this first involves physical cleaning (with a wooden or even metal pick) to remove the bulk of the chlorides and then chemical treatment. One chemical treatment is soaking the object in a 5% sodium sesquicarbonate solution. This serves to neutralize the acid that attac... | 0 | Metallurgy |
Fretting decreases fatigue strength of materials operating under cycling stress. This can result in fretting fatigue, whereby fatigue cracks can initiate in the fretting zone. Afterwards, the crack propagates into the material. Lap joints, common on airframe surfaces, are a prime location for fretting corrosion. This i... | 0 | Metallurgy |
The candidate editing sites were determined experimentally by comparison of cDNA sequences and genomically encoded DNA from the same individual to avoid single nucleotide polymorphisms (SNPs). Two of the three editing sites found in mouse gene were found in the human transcript.
However, only the Q/R site was detected ... | 1 | Gene expression + Signal Transduction |
Permeability is a property of foundry sand with respect to how well the sand can vent, i.e. how well gases pass through the sand. And in other words, permeability is the property by which we can know the ability of material to transmit fluid/gases. The permeability is commonly tested to see if it is correct for the cas... | 0 | Metallurgy |
Due to their extensive use, non-ferrous scrap metals are usually recycled. The secondary materials in scrap are vital to the metallurgy industry, as the production of new metals often needs them. Some recycling facilities re-smelt and recast non-ferrous materials; the dross is collected and stored onsite while the meta... | 0 | Metallurgy |
Zinc-finger nucleases consist of DNA binding domains that can precisely target a DNA sequence. Each zinc-finger can recognize codons of a desired DNA sequence, and therefore can be modularly assembled to bind to a particular sequence. These binding domains are coupled with a restriction endonuclease that can cause a do... | 1 | Gene expression + Signal Transduction |
In the 1990s, the Niihama copper refinery, owned by Sumitomo Metal Mining Company Limited (“Sumitomo”), treated copper anode slimes generated in-house, together with anode slimes from Sumitomo’s Toyo refinery and lead refinery slime from the Harima Imperial Smelting Process smelter. A total of 1200 tonnes per year (“t/... | 0 | Metallurgy |
CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus was named CCCTC binding factor. | 1 | Gene expression + Signal Transduction |
A grain boundary (GB) is the transition area or interface between adjacent crystallites (or grains) of the same chemical and lattice composition, not to be confused with a phase boundary. The adjacent grains do not have the same orientation of the lattice, thus giving the atoms in GB shifted positions relative to the l... | 0 | Metallurgy |
Geneticist Dean Hamer has suggested that a particular allele of the SLC18A2 gene correlates with spirituality using data from a smoking survey, which included questions intended to measure "self-transcendence". Hamer performed the spirituality study on the side, independently of the National Cancer Institute smoking st... | 1 | Gene expression + Signal Transduction |
The Westinghouse Lamp Plant located in Bloomfield, New Jersey, was one of the lamp manufacturing plants of Westinghouse Electric Corporation. The plant had a major involvement in supplying uranium metal for the world's first self-sustaining chain reaction in Chicago (Chicago Pile-1) in the early phase of the Manhattan ... | 0 | Metallurgy |
There is an inverse relationship between delta yield strength and grain size to some power, x.
where k is the strengthening coefficient and both k and x are material specific. Assuming a narrow monodisperse grain size distribution in a polycrystalline material, the smaller the grain size, the smaller the repulsion stre... | 0 | Metallurgy |
Copper extraction refers to the methods used to obtain copper from its ores. The conversion of copper ores consists of a series of physical, chemical and electrochemical processes. Methods have evolved and vary with country depending on the ore source, local environmental regulations, and other factors. | 0 | Metallurgy |
The Iron & Steel Museum of Alabama, also known as the Tannehill Museum, is an industrial museum that demonstrates iron production in the nineteenth-century Alabama located at Tannehill Ironworks Historical State Park in McCalla, Tuscaloosa County, Alabama. Opened in 1981, it covers .
The museum is an interpretive cente... | 0 | Metallurgy |
A number of examples of molecular mimicry by pathogens, emulating natural endogenous ligands of paired receptors for immune evasion, have been described in the literature. Such interactions are particularly common with the inhibitory members of receptor pairs, bolstering the hypothesis that activating partners are a la... | 1 | Gene expression + Signal Transduction |
The growth of Alabamas iron and steel industry was significantly influenced by Tannehill iron-making practices, such as using distilled coal residues as a furnace fuel, making early experimentation with coke, and reducing red iron ore from Red Mountain in a blast furnace. Due to the significant role that Tannehill pays... | 0 | Metallurgy |
The oxidizing gases flow upward, i.e., counter-current to the descending charge. In a well-insulated roaster, external heating is unnecessary except when the charge is highly moist. The hearth at the top of the roaster dries and heats the charge. Ignition and oxidation of the charge occur lower down. | 0 | Metallurgy |
A finery forge is a forge used to produce wrought iron from pig iron by decarburization in a process called "fining" which involved liquifying cast iron in a fining hearth and removing carbon from the molten cast iron through oxidation. Finery forges were used as early as the 3rd century BC in China. The finery forge p... | 0 | Metallurgy |
A fourth group has also been discovered and members have three amino acids between the two cysteines and is termed CXC chemokine (or d-chemokines). The only CXC chemokine discovered to date is called fractalkine (or CXCL1). It is both secreted and tethered to the surface of the cell that expresses it, thereby serving a... | 1 | Gene expression + Signal Transduction |
Marrow is part of I'm a Scientist, Get me out of here! energy generation zone. He has also been a key developer and academic consultant for the Dissemination of IT for the Promotion of Materials Science (DoITPoMS). Global Cycle Network Technology (GCN Tech) interviewed James about carbon fibre fatigue and strain in 20... | 0 | Metallurgy |
In the early 1990s, technical personnel from the then Union Miniére worked with MIM Holdings personnel to develop an ISASMELT-based process to treat scrap materials and residues containing copper and lead. Union Miniére operated a smelter at Hoboken, near Antwerpen in Belgium, that specialised in recycling scrap non-fe... | 0 | Metallurgy |
Members of the chemokine family are divided into four groups depending on the spacing of their first two cysteine residues. Thus the nomenclature for chemokines is, e.g.: CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor. | 1 | Gene expression + Signal Transduction |
SAC solders have outperformed high-Pb solders C4 joints in ceramic ball grid array (CBGA) systems, which are ball-grid arrays with a ceramic substrate. The CBGA showed consistently better results in thermal cycling for Pb-free alloys. The findings also show that SAC alloys are proportionately better in thermal fatigue ... | 0 | Metallurgy |
Barrier activity has been linked to the disruption of specific processes in the heterochromatin formation pathway. These types of insulators modify the nucleosomal substrate in the reaction cycle that is central to heterochromatin formation. Modifications are achieved through various mechanisms including nucleosome rem... | 1 | Gene expression + Signal Transduction |
Pitting corrosion is defined by localized attack, ranging from microns to millimeters in diameter, in an otherwise passive surface and only occurs for specific alloy and environmental combinations. Thus, this type of corrosion typically occurs in alloys that are protected by a tenacious (passivating) oxide film such as... | 0 | Metallurgy |
Epigenetic Therapy is the use of drugs or other epigenome-influencing techniques to treat medical conditions.
It is recently regarded as promising therapy to NSCLC.
As can be seen in the above, SFRP1 was downregulated epigenetically in NSCLC and was recently proposed as one of epigenetic therapy target. | 1 | Gene expression + Signal Transduction |
Corrosion in space is the corrosion of materials occurring in outer space. Instead of moisture and oxygen acting as the primary corrosion causes, the materials exposed to outer space are subjected to vacuum, bombardment by ultraviolet and X-rays, and high-energy charged particles (mostly electrons and protons from sola... | 0 | Metallurgy |
* ATRX-syndrome (α-thalassemia X-linked mental retardation) and α-thalassemia myelodysplasia syndrome are caused by mutations in ATRX, a SNF2-related ATPase with a PHD finger domain.
* CHARGE syndrome, an autosomal dominant disorder, has been linked recently to haploinsufficiency of CHD7, which encodes the CHD family A... | 1 | Gene expression + Signal Transduction |
VIM involves placing a core-less induction furnace into a vacuum chamber. The melting and casting operations are carried out at low pressures to control the entire alloy chemistry process. | 0 | Metallurgy |
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family. | 1 | Gene expression + Signal Transduction |
Spall are fragments of a material that are broken off a larger solid body. It can be produced by a variety of mechanisms, including as a result of projectile impact, corrosion, weathering, cavitation, or excessive rolling pressure (as in a ball bearing). Spalling and spallation both describe the process of surface fai... | 0 | Metallurgy |
In modern gas turbines, the turbine entry temperature (~1750K) exceeds superalloy incipient melting temperature (~1600K), with the help of surface engineering. | 0 | Metallurgy |
TLRs are a type of pattern recognition receptor (PRR) and recognize molecules that are broadly shared by pathogens but distinguishable from host molecules, collectively referred to as pathogen-associated molecular patterns (PAMPs). In addition to the recognition of exogenous PAMPs, TLRs can also bind to endogenous dama... | 1 | Gene expression + Signal Transduction |
Ceramide-1-phosphate (C1P) is formed by the action of ceramide kinase (CK) enzymes on Cer. C1P carry ionic charge at neutral pH and contain two hydrophobic chains making it relatively insoluble in aqueous environment. Thus, C1P reside in the organelle where it was formed and is unlikely to spontaneously flip-flop acr... | 1 | Gene expression + Signal Transduction |
Most transcription factors function in cooperation with other factors by protein–protein interactions. Association of MITF with other proteins is a critical step in the regulation of MITF-mediated transcriptional activity. Some commonly studied MITF interactions include those with MAZR, PIAS3, Tfe3, hUBC9, PKC1, and LE... | 1 | Gene expression + Signal Transduction |
Altered expression profiles in β-catenin have been associated with dilated cardiomyopathy in humans. β-Catenin upregulation of expression has generally been observed in patients with dilated cardiomyopathy. In a particular study, patients with end-stage dilated cardiomyopathy showed almost doubled estrogen receptor alp... | 1 | Gene expression + Signal Transduction |
Carbon Catabolite Repression—Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly(A) 3′-5′ exonuclease and a ubiquitin ligase. The exonuclease activity of CCR4-Not shortens the poly(A) tail found at 3' end of almost... | 1 | Gene expression + Signal Transduction |
Drosha shares striking structural similarity with the downstream ribonuclease Dicer, suggesting an evolutionary relationship, though Drosha and related enzymes are found only in animals while Dicer relatives are widely distributed, including among protozoans. Both components of the microprocessor complex are conserved ... | 1 | Gene expression + Signal Transduction |
For gene knockout investigations, RNA interference (RNAi), a more recent method, also known as gene silencing, has gained popularity. In RNA interference (RNAi), messenger RNA for a particular gene is inactivated using small interfering RNA (siRNA) or short hairpin RNA (shRNA). This effectively stops the gene from bein... | 1 | Gene expression + Signal Transduction |
In environmental chemistry, air sparging is an in situ remediation technique that removes volatile pollutants from contaminated groundwater and soil. | 0 | Metallurgy |
For many non-coding RNAs, including tRNA, rRNA, snRNA, and snoRNA, polyadenylation is a way of marking the RNA for degradation, at least in yeast. This polyadenylation is done in the nucleus by the TRAMP complex, which maintains a tail that is around 4 nucleotides long to the 3′ end. The RNA is then degraded by the ex... | 1 | Gene expression + Signal Transduction |
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